title: New HBM values for emerging substances, inventory of reference and HBM values in force, and working principles of the German Human Biomonitoring Commission.
abstract: The German Human Biomonitoring Commission (HBM Commission) derives health-related guidance values (Human Biomonitoring assessment values, HBM values) according to the procedures described in the HBM Commission's position papers. Since the last adaption of the methodology in 2014, the HBM Commission has established a series of new HBM values, mainly on the basis of internationally agreed TDI/RfD values, or of toxicologically well- founded points of departure observed in animal studies. The derivation of these new HBM values for HBCDD, triclosan, 2-MBT, PFOA and PFOS as well as for the metabolites of glycol ethers, of Hexamoll®DINCH®, DPHP, DEHTP, NMP, NEP, and 4-MBC is specified, and the HBM values are presented together with already established HBM values for other substances. Furthermore, the HBM Commission has defined provisional reference values for 2-methoxyacetic acid and for several parabens in the urine of the German population. It has also updated provisional reference values for PCB in the blood of the German population. An overview of all available reference values is given.
authors.affiliation: German Environment Agency, Dessau-Roßlau/Berlin, Germany. Electronic address: petra.apel@uba.de.
authors.forename: Petra
authors.initials: P
authors.lastname: Apel
authors.affiliation: Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Germany.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Angerer
authors.affiliation: Ruhr-University Bochum, Institute for Hygiene, Social and Environmental Medicine, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Wilhelm
authors.affiliation: German Environment Agency, Dessau-Roßlau/Berlin, Germany.
authors.forename: Marike
authors.initials: M
authors.lastname: Kolossa-Gehring
mesh_terms: D004784:Environmental Monitoring / Q000706:statistics & numerical data*; D004785:Environmental Pollutants / Q000097:blood / Q000652:urine; D005858:Germany; D006077:Government Agencies; D006801:Humans; D012016:Reference Values
chemical_list: D004785:Environmental Pollutants