title: 'Low grade glioma': an update for radiologists.
abstract: With the recent publication of a new World Health Organization brain tumour classification that reflects increased understanding of glioma tumour genetics, there is a need for radiologists to understand the changes and their implications for patient management. There has also been an increasing trend for adopting earlier, more aggressive surgical approaches to low-grade glioma (LGG) treatment. We will summarize these changes, give some context to the increased role of tumour genetics and discuss the associated implications of their adoption for radiologists. We will discuss the earlier and more radical surgical resection of LGG and what it means for patients undergoing imaging.
authors.affiliation: 1 Department of Radiology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Larsen
authors.affiliation: 2 Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK.|3 Department of Histopathology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
authors.forename: Steve B
authors.initials: SB
authors.lastname: Wharton
authors.affiliation: 4 Department of Neurology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
authors.forename: Fiona
authors.initials: F
authors.lastname: McKevitt
authors.affiliation: 1 Department of Radiology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
authors.forename: Charles
authors.initials: C
authors.lastname: Romanowski
authors.affiliation: 5 Specialist Cancer Services, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
authors.forename: Caroline
authors.initials: C
authors.lastname: Bridgewater
authors.affiliation: 6 Department of Neurosurgery, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
authors.forename: Hesham
authors.initials: H
authors.lastname: Zaki
authors.affiliation: 1 Department of Radiology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.|7 Academic Unit of Radiology, University of Sheffield, Sheffield, UK.|8 INSIGNEO Institute for in silico Medicine, University of Sheffield, Sheffield, UK.
authors.forename: Nigel
authors.initials: N
authors.lastname: Hoggard
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D003952:Diagnostic Imaging / Q000379:methods*; D005910:Glioma / Q000000981:diagnostic imaging* / Q000473:pathology*; D006801:Humans; D060787:Neoplasm Grading