title: Ectopic Myoglobin Expression Is Associated with a Favourable Outcome in Head and Neck Squamous Cell Carcinoma Patients.
abstract: Ectopic myoglobin (MB) expression, mediated by alternative and hypoxia-inducible transcription, has recently been demonstrated in several epithelial tumours. This study aimed to examine the expression of MB in hormone-independent head and neck squamous cell carcinomas (HNSCCs).
  
  
  
  Using imunohistochemistry, ectopic MB expression was analyzed on tissue microarrays (TMAs) of 524 patients with localized and locally advanced primary and recurrent HNSCC who had undergone surgical treatment with curative intent. Associations of MB expression with survival and clinicopathological parameters were analyzed.
  
  
  
  MB expression was found in 45.8% of HNSCC patients being significantly lower in normal adjacent tissue (NAT) compared to primary and recurrent tumours (p<0.001) and significantly associated with a favourable overall survival (OS) in HNSCC [p=0.037, hazard ratio (HR)=0.72, 95% confidence interval (CI)=0.53-0.98]. Furthermore, MB expression negatively correlated with human papillomavirus (HPV) status (p=0.013).
  
  
  
  MB is differentially expressed in HNSCC and correlates with a better OS.
authors.affiliation: Institute of Pathology, University Hospital Bonn, Bonn, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Meller
authors.affiliation: Institute of Pathology, University Hospital Bonn, Bonn, Germany.
authors.forename: Anne
authors.initials: A
authors.lastname: VAN Ellen
authors.affiliation: Institute of Pathology, University Hospital Bonn, Bonn, Germany.
authors.forename: Heidrun
authors.initials: H
authors.lastname: Gevensleben
authors.affiliation: Institute of Molecular Genetics, Johannes Gutenberg University, Mainz, Germany.
authors.forename: Anne
authors.initials: A
authors.lastname: Bicker
authors.affiliation: Institute of Molecular Genetics, Johannes Gutenberg University, Mainz, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Hankeln
authors.affiliation: Institute of Veterinary Physiology, Vetsuisse Faculty, University Zurich, Zurich, Switzerland.|Regenerative Medicine Program, University and University Hospital Zurich, Zurich, Switzerland.
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Gorr
authors.affiliation: Department of Pathology and Laboratory Medicine, New York Weill Cornell Medicine of Cornell University, New York, NY, U.S.A.|Englander Institute for Precision Medicine, Weill Cornell Medicine of Cornell University, New York, NY, U.S.A.
authors.forename: Verena
authors.initials: V
authors.lastname: Sailer
authors.affiliation: University Hospital Essen, Department of Otorhinolaryngology, Head and Neck Surgery, Essen, Germany.
authors.forename: Freya
authors.initials: F
authors.lastname: Dröge
authors.affiliation: LVR Hospital Bonn, Department of Addictive Disorders and Addiction Medicine, Bonn, Germany.
authors.forename: Friederike
authors.initials: F
authors.lastname: Schröck
authors.affiliation: Department of Otorhinolaryngology/Head and Neck Surgery, University Hospital Bonn, Bonn, Germany.
authors.forename: Friedrich
authors.initials: F
authors.lastname: Bootz
authors.affiliation: Department of Otorhinolaryngology/Head and Neck Surgery, University Hospital Bonn, Bonn, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Schröck
authors.affiliation: Department of Pathology, University Hospital of Lübeck, Lübeck, Germany.|Department of Pathology, Leibniz Research Center Borstel, Borstel, Germany.
authors.forename: Sven
authors.initials: S
authors.lastname: Perner
authors.affiliation: Institute of Pathology, University Hospital Bonn, Bonn, Germany dimo.dietrich@gmail.com.|Department of Otorhinolaryngology/Head and Neck Surgery, University Hospital Bonn, Bonn, Germany.
authors.forename: Dimo
authors.initials: D
authors.lastname: Dietrich
authors.affiliation: Institute of Pathology, University Hospital Bonn, Bonn, Germany.
authors.forename: Glen
authors.initials: G
authors.lastname: Kristiansen
mesh_terms: D000293:Adolescent; D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006258:Head and Neck Neoplasms / Q000378:metabolism*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D009211:Myoglobin / Q000378:metabolism*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D009211:Myoglobin
keywords: HPV; Myoglobin; head and neck squamous cell carcinoma; prognosis