title: Long non-coding RNA: a versatile regulator of the nuclear factor-κB signalling circuit.
abstract: The nuclear factor-κB (NF-κB) family of transcription factors play an essential role for the regulation of inflammatory responses, immune function and malignant transformation. Aberrant activity of this signalling pathway may lead to inflammation, autoimmune diseases and oncogenesis. Over the last two decades great progress has been made in the understanding of NF-κB activation and how the response is counteracted for maintaining tissue homeostasis. Therapeutic targeting of this pathway has largely remained ineffective due to the widespread role of this vital pathway and the lack of specificity of the therapies currently available. Besides regulatory proteins and microRNAs, long non-coding RNA (lncRNA) is emerging as another critical layer of the intricate modulatory architecture for the control of the NF-κB signalling circuit. In this paper we focus on recent progress concerning lncRNA-mediated modulation of the NF-κB pathway, and evaluate the potential therapeutic uses and challenges of using lncRNAs that regulate NF-κB activity.
authors.affiliation: Department of Biochemistry, Key Laboratory of Ministry of Education for Developmental Genes and Human Diseases, School of Medicine, Southeast University, Nanjing, Jiangsu, China.
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Mao
authors.affiliation: Department of Biochemistry, Key Laboratory of Ministry of Education for Developmental Genes and Human Diseases, School of Medicine, Southeast University, Nanjing, Jiangsu, China.
authors.forename: Zhenyi
authors.initials: Z
authors.lastname: Su
authors.affiliation: Department of Cell Biology, Harvard Medical School, Boston, MA, USA.
authors.forename: Adnan K
authors.initials: AK
authors.lastname: Mookhtiar
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000276:immunology*; D005786:Gene Expression Regulation; D015316:Genetic Therapy; D006706:Homeostasis; D006801:Humans; D007249:Inflammation / Q000276:immunology* / Q000628:therapy; D051379:Mice; D058990:Molecular Targeted Therapy; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism*; D062085:RNA, Long Noncoding / Q000235:genetics* / Q000627:therapeutic use; D015398:Signal Transduction
chemical_list: D016328:NF-kappa B; D062085:RNA, Long Noncoding
keywords: cancer; inflammation; long non-coding RNA; nuclear factor-κB signalling; regulation