title: The RAS/MAPK Axis Gets Stressed Out.
abstract: In this issue of Molecular Cell, Ritt et al. (2016) describe a stress-induced checkpoint that effectively suppresses RAS-MAPK signaling. This pathway, activated by agents such as Rigosertib that induce mitotic and oxidative stress, results in JNK-mediated inhibition of RAS-MAPK pathway components SOS and RAF.
authors.affiliation: Department of Discovery Oncology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
authors.forename: Scott A
authors.initials: SA
authors.lastname: Foster
authors.affiliation: Department of Discovery Oncology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address: shivam@gene.com.
authors.forename: Shiva
authors.initials: S
authors.lastname: Malek
mesh_terms: D019908:Proto-Oncogene Proteins c-raf; D015398:Signal Transduction / Q000187:drug effects*; D018631:ras Proteins
chemical_list: D019908:Proto-Oncogene Proteins c-raf; D018631:ras Proteins