title: Does the number of previous miscarriages influence the incidence of chromosomal aberrations in spontaneous pregnancy loss?
abstract: OBJECTIVE
  Chromosomal aberrations are a common cause for miscarriage. The purpose of this study was to evaluate factors that influence the frequency of chromosomal abnormalities in miscarriages and provide clinicians with a guideline for management of such cases.
  
  
  METHODS
  The study included 170 women who experienced pregnancy loss between the 2004 and 2014. Cytogenetic analysis of products of conception (POC) was routinely performed.
  
  
  RESULTS
  Successful cytogenetic analysis was achieved in 144 cases (84%). Of these, 78 cases (54%) had a chromosomal aberration. The incidence of chromosomal aberrations was not statistically significant among patients with 1, 2, 3, 4 or ≥5 previous miscarriages (33.3%, 57.4%, 48.6%, 65.2%, and 59.1%, respectively, p = 0.227). The F/M ratio was similar in normal and abnormal POC karyotypes (1.2:1 and 1.3:1, respectively, p = 0.7).
  
  
  CONCLUSIONS
  Contrary to previous assumptions we did not find correlation between number of previous spontaneous miscarriages a women experienced and chromosomal aberration in her current miscarriage.
authors.affiliation: a Prenatal Genetic Diagnosis Unit and Genetic Institute, Tel Aviv Sourasky Medical Center , Tel Aviv , Israel.
authors.forename: Myriam
authors.initials: M
authors.lastname: Goldstein
authors.affiliation: a Prenatal Genetic Diagnosis Unit and Genetic Institute, Tel Aviv Sourasky Medical Center , Tel Aviv , Israel.|b Sackler Faculty of Medicine, Tel Aviv University , Israel.|c Department of Obstetrics and Gynecology, Assaf Harofeh Medical Center , Zerifin, Israel.
authors.forename: Ran
authors.initials: R
authors.lastname: Svirsky
authors.affiliation: a Prenatal Genetic Diagnosis Unit and Genetic Institute, Tel Aviv Sourasky Medical Center , Tel Aviv , Israel.
authors.forename: Adi
authors.initials: A
authors.lastname: Reches
authors.affiliation: a Prenatal Genetic Diagnosis Unit and Genetic Institute, Tel Aviv Sourasky Medical Center , Tel Aviv , Israel.|b Sackler Faculty of Medicine, Tel Aviv University , Israel.
authors.forename: Yuval
authors.initials: Y
authors.lastname: Yaron
mesh_terms: D000026:Abortion, Habitual / Q000453:epidemiology* / Q000235:genetics*; D000022:Abortion, Spontaneous / Q000453:epidemiology* / Q000235:genetics*; D000328:Adult; D002869:Chromosome Aberrations / Q000706:statistics & numerical data*; D020732:Cytogenetic Analysis; D005260:Female; D020073:Gravidity / Q000502:physiology*; D006801:Humans; D015994:Incidence; D007621:Karyotyping; D008875:Middle Aged; D011247:Pregnancy; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult
keywords: Recurrent miscarriage; abortion; karyotype; pregnancy loss