title: Structural insights into functional amyloid inhibition in Gram -ve bacteria.
abstract: Amyloids are proteinaceous aggregates known for their role in debilitating degenerative diseases involving protein dysfunction. Many forms of functional amyloid are also produced in nature and often these systems require careful control of their assembly to avoid the potentially toxic effects. The best-characterised functional amyloid system is the bacterial curli system. Three natural inhibitors of bacterial curli amyloid have been identified and recently characterised structurally. Here, we compare common structural features of CsgC, CsgE and CsgH and discuss the potential implications for general inhibition of amyloid.
authors.affiliation: Department of Life Sciences, Imperial College London, South Kensington, London SW7 2AZ, U.K.
authors.forename: William
authors.initials: W
authors.lastname: Hawthorne
authors.affiliation: Department of Life Sciences, Imperial College London, South Kensington, London SW7 2AZ, U.K.
authors.forename: Sarah
authors.initials: S
authors.lastname: Rouse
authors.affiliation: Department of Life Sciences, Imperial College London, South Kensington, London SW7 2AZ, U.K.
authors.forename: Lee
authors.initials: L
authors.lastname: Sewell
authors.affiliation: Department of Life Sciences, Imperial College London, South Kensington, London SW7 2AZ, U.K.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Matthews
mesh_terms: D000682:Amyloid / Q000737:chemistry / Q000378:metabolism*; D001426:Bacterial Proteins / Q000737:chemistry / Q000378:metabolism*; D004926:Escherichia coli / Q000378:metabolism*; D029968:Escherichia coli Proteins / Q000737:chemistry / Q000378:metabolism*; D026901:Membrane Transport Proteins / Q000737:chemistry / Q000378:metabolism; D008958:Models, Molecular; D011487:Protein Conformation; D055672:Static Electricity
chemical_list: D000682:Amyloid; D001426:Bacterial Proteins; C556817:CsgC protein, E coli; C561979:CsgE protein, E coli; D029968:Escherichia coli Proteins; D026901:Membrane Transport Proteins; C077481:Crl protein, Bacteria
keywords: Fap; amyloid inhibitors; curli; functional amyloid