title: Chlorhexidine-Impregnated Dressings and Prevention of Catheter-Associated Bloodstream Infections in a Pediatric Intensive Care Unit.
abstract: BACKGROUND
  Bloodstream infections related to use of catheters are associated with increased morbidity and mortality rates, prolonged hospital lengths of stay, and increased medical costs.
  
  
  OBJECTIVE
  To compare the effectiveness of chlorhexidine-impregnated dressings with that of standard dressings in preventing catheter-related bloodstream infections.
  
  
  METHODS
  A total of 100 children were randomly divided into 2 groups of 50 each: a chlorhexidine group and a standard group. Patient care was provided in accordance with prevention bundles. Patients were followed up for development of catheter-related bloodstream infections.
  
  
  RESULTS
  Catheter colonization occurred in 4 patients in the standard group (8%) and in 1 patient in the chlorhexidine group (2%). Catheter-related bloodstream infections occurred in 5 patients in the standard group (10%) and in 1 patient in the chlorhexidine group (2%). Although more patients in the standard group had catheter-related bloodstream infections, the difference in infection rates between the 2 groups was not significant (P = .07).
  
  
  CONCLUSIONS
  Use of chlorhexidine-impregnated dressings reduced rates of catheter-related bloodstream infections, contamination, colonization, and local catheter infection in a pediatric intensive care unit but was not significantly better than use of standard dressings.
authors.affiliation: Duygu Sönmez Düzkaya is the director of nursing services and a nurse educator, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey. dygsnmz@hotmail.com dygsnmz@istanbul.edu.tr.|Nejla Canbulat Sahiner is an associate professor, Pediatric Nursing Department, Karamanoglu Mehmetbey University, Karaman, Turkey. dygsnmz@hotmail.com dygsnmz@istanbul.edu.tr.|Gülzade Uysal is an assistant professor, Okan University, Faculty of Health Sciences, Istanbul, Turkey. dygsnmz@hotmail.com dygsnmz@istanbul.edu.tr.|Tülay Yakut is a charge nurse, pediatric intensive care unit, Istanbul University, Istanbul Faculty of Medicine. dygsnmz@hotmail.com dygsnmz@istanbul.edu.tr.|Agop Çitak is a professor, pediatric intensive care unit, Acibadem Hospital, Istanbul, Turkey. dygsnmz@hotmail.com dygsnmz@istanbul.edu.tr.
authors.forename: Duygu Sönmez
authors.initials: DS
authors.lastname: Düzkaya
authors.affiliation: Duygu Sönmez Düzkaya is the director of nursing services and a nurse educator, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.|Nejla Canbulat Sahiner is an associate professor, Pediatric Nursing Department, Karamanoglu Mehmetbey University, Karaman, Turkey.|Gülzade Uysal is an assistant professor, Okan University, Faculty of Health Sciences, Istanbul, Turkey.|Tülay Yakut is a charge nurse, pediatric intensive care unit, Istanbul University, Istanbul Faculty of Medicine.|Agop Çitak is a professor, pediatric intensive care unit, Acibadem Hospital, Istanbul, Turkey.
authors.forename: Nejla Canbulat
authors.initials: NC
authors.lastname: Sahiner
authors.affiliation: Duygu Sönmez Düzkaya is the director of nursing services and a nurse educator, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.|Nejla Canbulat Sahiner is an associate professor, Pediatric Nursing Department, Karamanoglu Mehmetbey University, Karaman, Turkey.|Gülzade Uysal is an assistant professor, Okan University, Faculty of Health Sciences, Istanbul, Turkey.|Tülay Yakut is a charge nurse, pediatric intensive care unit, Istanbul University, Istanbul Faculty of Medicine.|Agop Çitak is a professor, pediatric intensive care unit, Acibadem Hospital, Istanbul, Turkey.
authors.forename: Gülzade
authors.initials: G
authors.lastname: Uysal
authors.affiliation: Duygu Sönmez Düzkaya is the director of nursing services and a nurse educator, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.|Nejla Canbulat Sahiner is an associate professor, Pediatric Nursing Department, Karamanoglu Mehmetbey University, Karaman, Turkey.|Gülzade Uysal is an assistant professor, Okan University, Faculty of Health Sciences, Istanbul, Turkey.|Tülay Yakut is a charge nurse, pediatric intensive care unit, Istanbul University, Istanbul Faculty of Medicine.|Agop Çitak is a professor, pediatric intensive care unit, Acibadem Hospital, Istanbul, Turkey.
authors.forename: Tülay
authors.initials: T
authors.lastname: Yakut
authors.affiliation: Duygu Sönmez Düzkaya is the director of nursing services and a nurse educator, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.|Nejla Canbulat Sahiner is an associate professor, Pediatric Nursing Department, Karamanoglu Mehmetbey University, Karaman, Turkey.|Gülzade Uysal is an assistant professor, Okan University, Faculty of Health Sciences, Istanbul, Turkey.|Tülay Yakut is a charge nurse, pediatric intensive care unit, Istanbul University, Istanbul Faculty of Medicine.|Agop Çitak is a professor, pediatric intensive care unit, Acibadem Hospital, Istanbul, Turkey.
authors.forename: Agop
authors.initials: A
authors.lastname: Çitak
mesh_terms: D016470:Bacteremia / Q000382:microbiology / Q000401:mortality / Q000517:prevention & control*; D017848:Blood-Borne Pathogens / Q000187:drug effects*; D055499:Catheter-Related Infections / Q000382:microbiology / Q000503:physiopathology / Q000517:prevention & control*; D002405:Catheterization, Central Venous / Q000009:adverse effects* / Q000379:methods; D002408:Catheters, Indwelling / Q000382:microbiology; D002710:Chlorhexidine / Q000494:pharmacology*; D003422:Critical Care / Q000379:methods; D005260:Female; D017052:Hospital Mortality / Q000639:trends; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D015278:Intensive Care Units, Pediatric; D008297:Male; D009779:Occlusive Dressings; D011322:Primary Prevention / Q000379:methods; D011379:Prognosis; D012016:Reference Values; D016896:Treatment Outcome; D014421:Turkey
chemical_list: D002710:Chlorhexidine