title: Diagnosing clean margins through Raman spectroscopy in human and animal mammary tumour surgery: a short review.
abstract: Breast cancer frequency in human and other mammal female populations has worryingly increased lately. The acute necessity for taxonomy of the aetiological factors along with seeking for new diagnostic tools and therapy procedures aimed at reducing mortality have yielded in an intense research effort worldwide. Surgery is a regular method to counteract extensive development of breast cancer and prevent metastases provided that negative surgical margins are achieved. This highly technical challenge requires fast, extremely sensitive and selective discrimination between malignant and benign tissues even down to molecular level. The particular advantages of Raman spectroscopy, such as high chemical specificity, and the ability to measure raw samples and optical responses in the visible or near-infrared spectral range, have recently recommended it as a means with elevated potential in precise diagnostic in oncology surgery. This review spans mainly the latter 10 years of exceptional efforts of scientists implementing Raman spectroscopy as a nearly real-time diagnostic tool for clean margins assessment in mastectomy and lumpectomy. Although greatly contributing to medical discoveries for the wealth of humanity, animals as patients have benefitted less from advances in surgery diagnostic using Raman spectroscopy. This work also dedicates a few lines to applications of surface enhanced Raman spectroscopy in veterinary oncological surgery.
authors.affiliation: Faculty of Veterinary Medicine-University of Agronomic Sciences and Veterinary Medicine , Bucharest , Romania.
authors.forename: I A
authors.initials: IA
authors.lastname: Birtoiu
authors.affiliation: ROXY VETERINARY S.R.L , Magurele , Romania.
authors.forename: C
authors.initials: C
authors.lastname: Rizea
authors.affiliation: Faculty of Veterinary Medicine-University of Agronomic Sciences and Veterinary Medicine , Bucharest , Romania.
authors.forename: D
authors.initials: D
authors.lastname: Togoe
authors.affiliation: Faculty of Veterinary Medicine-University of Agronomic Sciences and Veterinary Medicine , Bucharest , Romania.
authors.forename: R M
authors.initials: RM
authors.lastname: Munteanu
authors.affiliation: Faculty of Veterinary Medicine-University of Agronomic Sciences and Veterinary Medicine , Bucharest , Romania.
authors.forename: C
authors.initials: C
authors.lastname: Micsa
authors.affiliation: National Institute of Research and Development for Optoelectronics INOE 2000 , Magurele , Romania.
authors.forename: M I
authors.initials: MI
authors.lastname: Rusu
authors.affiliation: National Institute of Research and Development for Optoelectronics INOE 2000 , Magurele , Romania.
authors.forename: M
authors.initials: M
authors.lastname: Tautan
authors.affiliation: National Institute of Research and Development for Optoelectronics INOE 2000 , Magurele , Romania.
authors.forename: L
authors.initials: L
authors.lastname: Braic
authors.affiliation: National Institute of Research and Development for Optoelectronics INOE 2000 , Magurele , Romania.
authors.forename: L O
authors.initials: LO
authors.lastname: Scoicaru
authors.affiliation: National Institute of Research and Development for Optoelectronics INOE 2000 , Magurele , Romania.
authors.forename: A
authors.initials: A
authors.lastname: Parau
authors.affiliation: APEL LASER S.R.L., Bucharest, Romania; Faculty of Physics, University of Bucharest, Bucharest, Romania.
authors.forename: N D
authors.initials: ND
authors.lastname: Becherescu-Barbu
authors.affiliation: APEL LASER S.R.L. , Bucharest , Romania.
authors.forename: M V
authors.initials: MV
authors.lastname: Udrea
authors.affiliation: Aix-Marseille Université , Centrale Marseille, CNRS, Fédération Sciences Chimiques Marseille (FR 1739) - PRATIM, 13000 Marseille , France.
authors.forename: A
authors.initials: A
authors.lastname: Tonetto
authors.affiliation: Aix-Marseille Université , Centrale Marseille, CNRS, Fédération Sciences Chimiques Marseille (FR 1739) - PRATIM, 13000 Marseille , France.
authors.forename: R
authors.initials: R
authors.lastname: Notonier
authors.affiliation: National Institute of Research and Development for Optoelectronics INOE 2000 , Magurele , Romania.
authors.forename: C E A
authors.identifier: 0000-0002-1609-8001
authors.initials: CE
authors.lastname: Grigorescu
keywords: clean surgical margin; comparative oncology; dog mastectomy; in vivo diagnostic through Raman spectroscopy; mammary tumour; surface enhanced Raman scattering in veterinary surgery