title: Metabolomics and Its Application in the Development of Discovering Biomarkers for Osteoporosis Research.
abstract: Osteoporosis is a progressive skeletal disorder characterized by low bone mass and increased risk of fracture in later life. The incidence and costs associated with treating osteoporosis cause heavy socio-economic burden. Currently, the diagnosis of osteoporosis mainly depends on bone mineral density and bone turnover markers. However, these indexes are not sensitive and accurate enough to reflect the osteoporosis progression. Metabolomics offers the potential for a holistic approach for clinical diagnoses and treatment, as well as understanding of the pathological mechanism of osteoporosis. In this review, we firstly describe the study subjects of osteoporosis and bio-sample preparation procedures for different analytic purposes, followed by illustrating the biomarkers with potentially predictive, diagnosis and pharmaceutical values when applied in osteoporosis research. Then, we summarize the published metabolic pathways related to osteoporosis. Furthermore, we discuss the importance of chronological data and combination of multi-omics in fully understanding osteoporosis. The application of metabolomics in osteoporosis could provide researchers the opportunity to gain new insight into the metabolic profiling and pathophysiological mechanisms. However, there is still much to be done to validate the potential biomarkers responsible for the progression of osteoporosis and there are still many details needed to be further elucidated.
authors.affiliation: Institute for Advancing Translational Medicine in Bone & Joint Disease, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong 999077, China. lvhuan1988@aliyun.com.|Institute of Precision Medicine and Innovative Drug Discovery, HKBU (Haimen) Institute of Science and Technology, Haimen 226133, China. lvhuan1988@aliyun.com.
authors.forename: Huanhuan
authors.initials: H
authors.lastname: Lv
authors.affiliation: Institute for Advancing Translational Medicine in Bone & Joint Disease, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong 999077, China. jiangfenghz@163.com.|Institute of Precision Medicine and Innovative Drug Discovery, HKBU (Haimen) Institute of Science and Technology, Haimen 226133, China. jiangfenghz@163.com.
authors.forename: Feng
authors.initials: F
authors.lastname: Jiang
authors.affiliation: Institute for Advancing Translational Medicine in Bone & Joint Disease, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong 999077, China. guanyufei122@163.com.
authors.forename: Daogang
authors.initials: D
authors.lastname: Guan
authors.affiliation: Institute for Advancing Translational Medicine in Bone & Joint Disease, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong 999077, China. cheng0816@163.com.|Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China. cheng0816@163.com.
authors.forename: Cheng
authors.initials: C
authors.lastname: Lu
authors.affiliation: Institute for Advancing Translational Medicine in Bone & Joint Disease, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong 999077, China. boris.g.guo@gmail.com.
authors.forename: Baosheng
authors.initials: B
authors.lastname: Guo
authors.affiliation: Institute for Advancing Translational Medicine in Bone & Joint Disease, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong 999077, China. clchan@hkbu.edu.hk.
authors.forename: Chileung
authors.initials: C
authors.lastname: Chan
authors.affiliation: Deparment of Spine Surgery, Shenzheng People's Hospital, Shenzheng 518020, China. psling824@163.com.
authors.forename: Songlin
authors.initials: S
authors.lastname: Peng
authors.affiliation: Zhengzhou Hospital of Traditional Chinese Medicine, Zhengzhou 450007, China. liubqmm@163.com.
authors.forename: Baoqin
authors.initials: B
authors.lastname: Liu
authors.affiliation: Zhengzhou Hospital of Traditional Chinese Medicine, Zhengzhou 450007, China. gww555@sina.com.
authors.forename: Wenwei
authors.initials: W
authors.lastname: Guo
authors.affiliation: Institute for Advancing Translational Medicine in Bone & Joint Disease, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong 999077, China. hailong.zhu@gmail.com.
authors.forename: Hailong
authors.initials: H
authors.lastname: Zhu
authors.affiliation: Zhengzhou Hospital of Traditional Chinese Medicine, Zhengzhou 450007, China. xuxg1115@126.com.
authors.forename: Xuegong
authors.initials: X
authors.lastname: Xu
authors.affiliation: Institute for Advancing Translational Medicine in Bone & Joint Disease, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong 999077, China. aipinglu@hkbu.edu.hk.|Institute of Arthritis Research, Shanghai Academy of Chinese Medical Sciences, Guanghua Integrative Medicine Hospital/Shanghai University of Traditional Chinese Medicine, Shanghai 200052, China. aipinglu@hkbu.edu.hk.
authors.forename: Aiping
authors.initials: A
authors.lastname: Lu
authors.affiliation: Institute for Advancing Translational Medicine in Bone & Joint Disease, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong 999077, China. zhangge@hkbu.edu.hk.
authors.forename: Ge
authors.initials: G
authors.lastname: Zhang
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism*; D035843:Biomedical Research; D004195:Disease Models, Animal; D006801:Humans; D055432:Metabolomics / Q000379:methods*; D010024:Osteoporosis / Q000188:drug therapy / Q000378:metabolism*
chemical_list: D015415:Biomarkers
keywords: biomarkers; chronological data; metabolic pathways; metabolomics; multi-omics; osteoporosis