title: The role of the IGF-1 Ec in myoskeletal system and osteosarcoma pathophysiology.
abstract: Growth hormone (GH) regulated mainly liver-produced insulin-like growth factor 1 (IGF-1) is a key molecule in embryonic & post embryonic development that is also involved in cancer biology. Herein we review new insights of the role of igf-1 gene products and of the IGF-1Ec isoform in muscle and bone development/repair and its role in osteosarcoma pathophysiology, underlying the possible role of the Ec peptide as a future therapeutic target.
authors.affiliation: Physiology Laboratory, Athens Medical School, National and Kapodestrian University of Athens, Greece; Third orthopaedic clinic, KAT General Hospital, Kifisia, Attiki, Greece. Electronic address: narmakolas@gmail.com.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Armakolas
authors.affiliation: Physiology Laboratory, Athens Medical School, National and Kapodestrian University of Athens, Greece. Electronic address: aarmakol@med.uoa.gr.
authors.forename: Athanasios
authors.initials: A
authors.lastname: Armakolas
authors.affiliation: Third orthopaedic clinic, KAT General Hospital, Kifisia, Attiki, Greece. Electronic address: thanosarmakolas@yahoo.com.
authors.forename: Athanasios
authors.initials: A
authors.lastname: Antonopoulos
authors.affiliation: Physiology Laboratory, Athens Medical School, National and Kapodestrian University of Athens, Greece. Electronic address: dhmakak@med.uoa.gr.
authors.forename: Andreas
authors.initials: A
authors.lastname: Dimakakos
authors.affiliation: Physiology Laboratory, Athens Medical School, National and Kapodestrian University of Athens, Greece. Electronic address: stathakimg@yahoo.gr.
authors.forename: Martha
authors.initials: M
authors.lastname: Stathaki
authors.affiliation: Physiology Laboratory, Athens Medical School, National and Kapodestrian University of Athens, Greece. Electronic address: mkoutsil@med.uoa.gr.
authors.forename: Michael
authors.initials: M
authors.lastname: Koutsilieris
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000235:genetics / Q000378:metabolism*; D012516:Osteosarcoma / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism
chemical_list: C583557:IGF1 protein, human; D020033:Protein Isoforms; D007334:Insulin-Like Growth Factor I
keywords: Bone; Ec peptide; IGF-1; IGF-1Ec; IGF-1R; Muscle repair; Osteosarcoma