title: Relationship between the Finnish Diabetes Risk Score (FINDRISC), vitamin D levels, and insulin resistance in obese subjects.
abstract: To assess the relationship between 25-hydroxyvitamin D [25(OH)D] blood concentrations in subjects with obesity and type 2 diabetes mellitus (T2D) risk according to the Finnish Diabetes Risk Score (FINDRISC) modified for Latin America (LA-FINDRISC).
  
  
  
  This study was conducted in Ciudad Bolívar, Venezuela. Eighty two women and 20 men (53 obese and 49 nonobese), with an average age of 42.6±12.30 years were enrolled. Weight, height, body mass index (BMI), waist circumference (WC), fasting glucose, basal insulin, plasma lipids, Homeostasis Model Assessment-Insulin Resistance (HOMA-IR), and 25(OH)D levels were measured. FINDRISC with WC cutoff points modified for Latin America was applied.
  
  
  
  No difference in 25(OH)D levels between obese and nonobese subjects was found. When anthropometric, clinical, and biochemical variables according to the 25(OH)D status were compared, the only difference detected was higher LA-FINDRISC in the insufficient/low 25(OH)D group compared to normal 25(OH)D levels group (12.75±6.62; vs 10.15±5.21; p=0.031). LA-FINDRISC was negatively correlated with plasma 25(OH)D levels (r=-0.302; p=0.002) and positively correlated with the HOMA-IR index (r=0.637; p=0.0001).
  
  
  
  The LA-FINDRISC significantly correlated with both 25(OH)D levels and insulin resistance markers in this group of patients.
authors.affiliation: Endocrinology, Diabetes, Metabolism and Nutrition Unit, Ciudad Bolívar, Venezuela; Physiological Sciences Department, Universidad de Oriente, Ciudad Bolívar, Venezuela. Electronic address: marcoslimamedical@hotmail.com.
authors.forename: Marcos M
authors.initials: MM
authors.lastname: Lima-Martínez
authors.affiliation: Physiological Sciences Department, Universidad de Oriente, Ciudad Bolívar, Venezuela.
authors.forename: Carlos
authors.initials: C
authors.lastname: Arrau
authors.affiliation: Physiological Sciences Department, Universidad de Oriente, Ciudad Bolívar, Venezuela.
authors.forename: Saimar
authors.initials: S
authors.lastname: Jerez
authors.affiliation: Autonomous Institute the Andes University Hospital, Endocrinology Unit, Mérida, Venezuela.
authors.forename: Mariela
authors.initials: M
authors.lastname: Paoli
authors.affiliation: The Andes Clinic of Cardio-Metabolic Studies, Mérida, Venezuela.
authors.forename: Juan P
authors.initials: JP
authors.lastname: González-Rivas
authors.affiliation: Department of Physiology, School of Medicine, Universidad Centro-Occidental "Lisandro Alvarado" and Cardio-metabolic Unit 7, Barquisimeto, Venezuela; Department of Physiology, School of Medicine, University of Panamá, Panama City, Panama.
authors.forename: Ramfis
authors.initials: R
authors.lastname: Nieto-Martínez
authors.affiliation: Division of Endocrinology, Department of Medicine, University of Miami Miller School of Medicine, Miami, USA.
authors.forename: Gianluca
authors.initials: G
authors.lastname: Iacobellis
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D005215:Fasting / Q000097:blood; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000175:diagnosis; D011237:Predictive Value of Tests; D018570:Risk Assessment; D012307:Risk Factors; D011795:Surveys and Questionnaires; D014687:Venezuela; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D055105:Waist Circumference
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D007328:Insulin; D008055:Lipids; D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: Findrisc; Insulin resistance; Obesity; Type 2 diabetes mellitus; Vitamin D