title: Novel Application of Cellulose Paper As a Platform for the Macromolecular Self-Assembly of Biomimetic Giant Liposomes.
abstract: We report a facile and scalable method to fabricate biomimetic giant liposomes by using a cellulose paper-based materials platform. Termed PAPYRUS for Paper-Abetted liPid hYdRation in aqUeous Solutions, the method is general and can produce liposomes in various aqueous media and at elevated temperatures. Encapsulation of macromolecules and production of liposomes with membranes of complex compositions is straightforward. The ease of manipulation of paper makes practical massive parallelization and scale-up of the fabrication of giant liposomes, demonstrating for the first time the surprising usefulness of paper as a platform for macromolecular self-assembly.
authors.affiliation: School of Engineering and §School of Natural Sciences, University of California , Merced, California 95343, United States.
authors.forename: Kayleigh M
authors.initials: KM
authors.lastname: Kresse
authors.affiliation: School of Engineering and §School of Natural Sciences, University of California , Merced, California 95343, United States.
authors.forename: Melissa
authors.initials: M
authors.lastname: Xu
authors.affiliation: School of Engineering and §School of Natural Sciences, University of California , Merced, California 95343, United States.
authors.forename: Joseph
authors.initials: J
authors.lastname: Pazzi
authors.affiliation: School of Engineering and §School of Natural Sciences, University of California , Merced, California 95343, United States.
authors.forename: Marcos
authors.initials: M
authors.lastname: García-Ojeda
authors.affiliation: School of Engineering and §School of Natural Sciences, University of California , Merced, California 95343, United States.
authors.forename: Anand Bala
authors.initials: AB
authors.lastname: Subramaniam
mesh_terms: D032701:Biomimetics; D002482:Cellulose / Q000737:chemistry*; D008055:Lipids; D008081:Liposomes; D046911:Macromolecular Substances
chemical_list: D008055:Lipids; D008081:Liposomes; D046911:Macromolecular Substances; D002482:Cellulose
keywords: cellulose; encapsulation; giant unilamellar vesicles; paper; synthetic cells