title: The Therapeutic Potential of T Cell Metabolism.
abstract: Transplant rejection mediated by the adaptive immune system remains a major barrier to achieving long-term tolerance and graft survival. Emerging evidence indicates that lymphocytes rapidly shift their metabolic programs in response to activation, co-stimulatory, and cytokine signals to support required effector cell differentiation and function. These observations have led to the hypothesis that manipulating the metabolic programs of immune cells could serve as a powerful therapeutic strategy for attenuating deleterious immune responses and facilitating durable tolerance in the setting of allogeneic solid organ or bone marrow transplant. In this mini-review, we introduce the fundamentals of metabolism, highlight the current understanding of how adaptive immune cells utilize their metabolic programs, and discuss the potential for targeting metabolism as a therapeutic approach to induce tolerance in the transplant setting.
authors.affiliation: Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles, CA.
authors.forename: A
authors.initials: A
authors.lastname: Zarrinpar
authors.affiliation: Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA.|Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA.
authors.forename: S J
authors.initials: SJ
authors.lastname: Bensinger
mesh_terms: D006084:Graft Rejection / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D016377:Organ Transplantation / Q000009:adverse effects*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D023001:Transplantation Tolerance / Q000276:immunology*
keywords: T cell biology; basic (laboratory) research/science; immune regulation; immunobiology; immunosuppression/immune modulation; metabolism/metabolite; molecular biology; translational research/science