title: Intermolecular Aryl C-H Amination through Sequential Iron and Copper Catalysis.
abstract: A mild, efficient and regioselective method for para-amination of activated arenes has been developed through a combination of iron and copper catalysis. A diverse range of products were obtained from an operationally simple one-pot, two-step procedure involving bromination of the aryl substrate with the powerful Lewis acid iron(III) triflimide, followed by a copper(I)-catalysed N-arylation reaction. This two-step dehydrogenative process for the regioselective coupling of aromatic C-H bonds with non-activated amines was applicable to anisole-, phenol-, aniline- and acetanilide-type aryl compounds. Importantly, the arene substrates were used as the limiting reagent and required no protecting-group manipulations during the transformation.
authors.affiliation: WestCHEM, School of Chemistry, The Joseph Black Building, University of Glasgow, University Avenue, Glasgow, G12 8QQ, UK.
authors.forename: Mohamed A B
authors.initials: MA
authors.lastname: Mostafa
authors.affiliation: WestCHEM, School of Chemistry, The Joseph Black Building, University of Glasgow, University Avenue, Glasgow, G12 8QQ, UK.
authors.forename: Ewen D D
authors.initials: ED
authors.lastname: Calder
authors.affiliation: WestCHEM, School of Chemistry, The Joseph Black Building, University of Glasgow, University Avenue, Glasgow, G12 8QQ, UK.
authors.forename: Daugirdas T
authors.initials: DT
authors.lastname: Racys
authors.affiliation: WestCHEM, School of Chemistry, The Joseph Black Building, University of Glasgow, University Avenue, Glasgow, G12 8QQ, UK.
authors.forename: Andrew
authors.identifier: http://orcid.org/0000-0001-7907-5766
authors.initials: A
authors.lastname: Sutherland
keywords: amination; bromination; copper catalysis; cross-coupling; iron catalysis