title: Biomimetic Approaches for Bone Tissue Engineering.
abstract: Although autologous bone grafts are considered a gold standard for the treatment of bone defects, they are limited by donor site morbidities and geometric requirements. We propose that tissue engineering technology can overcome such limitations by recreating fully viable and biological bone grafts. Specifically, we will discuss the use of bone scaffolds and autologous cells with bioreactor culture systems as a tissue engineering paradigm to grow bone in vitro. We will also discuss emergent vascularization strategies to promote graft survival in vivo, as well as the role of inflammation during bone repair. Finally, we will highlight some recent advances and discuss new solutions to bone repair inspired by endochondral ossification.
authors.affiliation: 1 Department of Biomedical Engineering, Columbia University , New York, New York.
authors.forename: Johnathan
authors.initials: J
authors.lastname: Ng
authors.affiliation: 2 School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, Pennsylvania.
authors.forename: Kara
authors.initials: K
authors.lastname: Spiller
authors.affiliation: 1 Department of Biomedical Engineering, Columbia University , New York, New York.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Bernhard
authors.affiliation: 1 Department of Biomedical Engineering, Columbia University , New York, New York.|3 Department of Medicine, Columbia University , New York, New York.
authors.forename: Gordana
authors.initials: G
authors.lastname: Vunjak-Novakovic
mesh_terms: D000818:Animals; D032701:Biomimetics / Q000379:methods*; D019149:Bioreactors; D001842:Bone and Bones / Q000502:physiology*; D006801:Humans; D018919:Neovascularization, Physiologic; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry
keywords: biomimetics; bone; tissue engineering