title: Role of the intestinal mucosa in acute gastrointestinal GVHD.
abstract: Intestinal graft-versus-host disease (GVHD) remains a significant obstacle to the success of allogeneic hematopoietic cell transplantation. The intestinal mucosa comprises the inner lining of the intestinal tract and maintains close proximity with commensal microbes that reside within the intestinal lumen. Recent advances have significantly improved our understanding of the interactions between the intestinal mucosa and the enteric microbiota. Changes in host mucosal tissue and commensals posttransplant have been actively investigated, and provocative insights into mucosal immunity and the enteric microbiota are now being translated into clinical trials of novel approaches for preventing and treating acute GVHD. In this review, we summarize recent findings related to aspects of the intestinal mucosa during acute GVHD.
authors.affiliation: Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY; and.|Weill Cornell Medical College, New York, NY.
authors.forename: Jonathan U
authors.initials: JU
authors.lastname: Peled
authors.affiliation: Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY; and.
authors.forename: Alan M
authors.initials: AM
authors.lastname: Hanash
authors.affiliation: Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY; and.|Weill Cornell Medical College, New York, NY.
authors.forename: Robert R
authors.initials: RR
authors.lastname: Jenq
mesh_terms: D000208:Acute Disease; D064591:Allografts; D002986:Clinical Trials as Topic; D005767:Gastrointestinal Diseases / Q000209:etiology / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control; D000069196:Gastrointestinal Microbiome / Q000276:immunology*; D006086:Graft vs Host Disease / Q000209:etiology / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D018928:Immunity, Mucosal; D007413:Intestinal Mucosa / Q000276:immunology / Q000382:microbiology / Q000473:pathology