title: Extracellular matrix endocytosis in controlling matrix turnover and beyond: emerging roles in cancer.
abstract: The extracellular matrix (ECM) is a network of secreted proteins that, beyond providing support for tissues and organs, is involved in the regulation of a variety of cell functions, including cell proliferation, polarity, migration and oncogenic transformation. ECM homeostasis is maintained through a tightly controlled balance between synthesis, deposition and degradation. While the role of metalloproteases in ECM degradation is widely recognised, the contribution of ECM internalisation and intracellular degradation to ECM maintenance has been mostly overlooked. In this review, I will summarise what is known about the molecular mechanisms mediating ECM endocytosis and how this process impacts on diseases, such as fibrosis and cancer.
authors.affiliation: Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, U.K.
authors.forename: Elena
authors.initials: E
authors.lastname: Rainero
mesh_terms: D000818:Animals; D002465:Cell Movement; D004705:Endocytosis; D005109:Extracellular Matrix / Q000378:metabolism*; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D020782:Matrix Metalloproteinases / Q000378:metabolism; D008954:Models, Biological; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D016326:Extracellular Matrix Proteins; D020782:Matrix Metalloproteinases
keywords: ECM remodelling; ECM turnover; cancer; cell invasion; endocytosis; extracellular matrix