title: Vulvar Intraepithelial Neoplasia 3 in Women Less Than 35 Years.
abstract: OBJECTIVE
  To examine the outcome of women diagnosed with vulvar intraepithelial neoplasia (VIN) 3 at less than 35 years.
  
  
  METHODS
  All cases of VIN 3 treated in women less than 35 years treated at Roswell Park Cancer Institute between January 1973 and January 2008 were reviewed. Medical records were reviewed for year of diagnosis, treatment modality, recurrence and/or progression, associated medical conditions, history of genital condyloma, smoking status, history of cervical pathology, and treatment.
  
  
  RESULTS
  Thirty-one women were identified. The mean age at diagnosis was 29 years. Smoking status was available in 28 patients, of which 82% (23/28) were current or former smokers. Eighty-one percent (25/31) of the women had cervical disease. Fifty-two percent (16/31) had a history of genital condyloma. Ten of the 31 women (32%) were diagnosed with persistence or recurrence of VIN 3. Three women (9.7%) progressed to invasive carcinoma.
  
  
  CONCLUSIONS
  Women diagnosed with VIN 3 at less than 35 years are at risk for persistence and/or recurrence of their disease as well as progression to carcinoma, warranting frequent and prolonged follow-up with liberal utilization of directed biopsies of suspicious lesions.
authors.affiliation: Division of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, NY.
authors.forename: Joshua P
authors.initials: JP
authors.lastname: Kesterson
authors.affiliation: Division of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, NY.
authors.forename: Shashikant
authors.initials: S
authors.lastname: Lele
mesh_terms: D000328:Adult; D002278:Carcinoma in Situ / Q000473:pathology*; D002294:Carcinoma, Squamous Cell; D003218:Condylomata Acuminata; D005260:Female; D006801:Humans; D009364:Neoplasm Recurrence, Local; D014846:Vulvar Neoplasms / Q000473:pathology*
keywords: VIN 3; vulvar cancer