title: Human to human transmission of arthropod-borne pathogens.
abstract: Human-to-human (H2H) transmitted arthropod-borne pathogens are a growing burden worldwide, with malaria and dengue being the most common mosquito-borne H2H transmitted diseases. The ability of vectors to get infected by humans during a blood meal to further propel an epidemic depends on complex interactions between pathogens, vectors and humans, in which human interventions and demographic and environmental conditions play a significant role. Herein, we discuss the distal and proximal drivers affecting H2H vector-borne pathogen transmission and identify knowledge gaps and future perspectives.
authors.affiliation: Viroscience Laboratory, Erasmus Medical Centre, Rotterdam, The Netherlands; Artemis One Health Research Institute, Utrecht, The Netherlands.
authors.forename: Byron E
authors.initials: BE
authors.lastname: Martina
authors.affiliation: Department of Molecular Medicine, University of Padova, Padova, Italy.
authors.forename: Luisa
authors.initials: L
authors.lastname: Barzon
authors.affiliation: Laboratory of Virology, Wageningen University, Wageningen, The Netherlands.
authors.forename: Gorben P
authors.initials: GP
authors.lastname: Pijlman
authors.affiliation: SaBio, Instituto de Investigación en Recursos Cinegéticos IREC-CSIC-UCLM-JCCM, Ciudad Real, Spain; Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK, USA.
authors.forename: José
authors.initials: J
authors.lastname: de la Fuente
authors.affiliation: Research and Innovation Centre, Fondazione Edmund Mach, San Michele all'Adige (Trento), Italy.
authors.forename: Annapaola
authors.initials: A
authors.lastname: Rizzoli
authors.affiliation: Department of Microbiology & Infectious Diseases, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Linda J
authors.initials: LJ
authors.lastname: Wammes
authors.affiliation: Laboratory of Entomology, Wageningen University, Wageningen, The Netherlands.
authors.forename: Willem
authors.initials: W
authors.lastname: Takken
authors.affiliation: Department of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: Ronald P
authors.initials: RP
authors.lastname: van Rij
authors.affiliation: Department of Microbiology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece. Electronic address: annap@med.auth.gr.
authors.forename: Anna
authors.initials: A
authors.lastname: Papa
mesh_terms: D000818:Animals; D001179:Arthropod Vectors; D001424:Bacterial Infections / Q000635:transmission*; D018562:Disease Transmission, Infectious; D006801:Humans; D010272:Parasitic Diseases / Q000635:transmission*; D014777:Virus Diseases / Q000635:transmission*