title: Additional Evidence Supports Association of Common Variants in COL11A1 with Increased Risk of Hip Osteoarthritis Susceptibility.
abstract: OBJECTIVE
  In a recent study single nucleotide polymorphisms (SNPs) in the COL11A1 gene were found to be associated with hip osteoarthritis (OA) among European populations. In this study, our aim was to identify common genetic variants in COL11A1 predisposing to primary hip OA in Han Chinese individuals.
  
  
  METHODS
  We designed a case-control study that included 313 hip OA patients and 911 unrelated healthy controls. Fourteen tagging single-nucleotide polymorphisms (SNPs) were genotyped, and single SNP and haplotypic association analyses were performed.
  
  
  RESULTS
  Two SNPs (rs1241164 and rs4907986) were found to be significantly associated with hip OA risk (adjusted p = 0.000731 and 0.000477). An increased risk of OA was associated with possession of the C allele of rs1241164 (adjusted odds ratio [OR] = 1.73, 95% confidence interval [CI] = 1.27-2.36) and the T allele of rs4907986 (adjusted OR = 1.72, 95% CI = 1.24-2.35). Similar results were confirmed via genotypic association analyses. Moreover, two different haplotype blocks, including rs1241164 and rs4907986, respectively, were found to be strongly associated with hip OA risk as well.
  
  
  CONCLUSIONS
  Variants in the COL11A1 gene modify individual susceptibility to hip OA in the Han Chinese population.
authors.affiliation: 1 Department of Laboratory Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an, China .
authors.forename: Jinhua
authors.initials: J
authors.lastname: Wang
authors.affiliation: 2 The First Department of Orthopedic, The Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an, China .
authors.forename: Chen
authors.initials: C
authors.lastname: Zhang
authors.affiliation: 3 Department of Energy, Environment and Chemical Engineering, Washington University , Saint Louis, Missouri.
authors.forename: Stephen G
authors.initials: SG
authors.lastname: Wu
authors.affiliation: 4 Department of Hand Surgery, Honghui Affiliated Hospital of Xi'an Jiaotong University , Xi'an, China .
authors.forename: Chi
authors.initials: C
authors.lastname: Shang
authors.affiliation: 1 Department of Laboratory Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an, China .
authors.forename: Lun
authors.initials: L
authors.lastname: Huang
authors.affiliation: 1 Department of Laboratory Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an, China .
authors.forename: Tong
authors.initials: T
authors.lastname: Zhang
authors.affiliation: 1 Department of Laboratory Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an, China .
authors.forename: Wen
authors.initials: W
authors.lastname: Zhang
authors.affiliation: 1 Department of Laboratory Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an, China .
authors.forename: Yanping
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: 1 Department of Laboratory Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an, China .
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China; D024161:Collagen Type XI / Q000235:genetics* / Q000378:metabolism; D005006:Ethnicity / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies / Q000379:methods; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D015207:Osteoarthritis, Hip / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: C574182:COL11A1 protein, human; D024161:Collagen Type XI
keywords: genetics; osteoarthritis; single-nucleotide polymorphisms