title: Rapamycin preferentially inhibits human IL-5+TH2-cell proliferation via an mTORC1/S6 kinase-1-dependent pathway.
authors.affiliation: Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
authors.forename: Yuzhi
authors.initials: Y
authors.lastname: Yin
authors.affiliation: Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
authors.forename: Alyssa
authors.initials: A
authors.lastname: Mitson-Salazar
authors.affiliation: Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Wansley
authors.affiliation: Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
authors.forename: Satya P
authors.initials: SP
authors.lastname: Singh
authors.affiliation: Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md. Electronic address: cprussin@niaid.nih.gov.
authors.forename: Calman
authors.initials: C
authors.lastname: Prussin
mesh_terms: D000328:Adult; D039741:Antigens, Dermatophagoides / Q000276:immunology; D000956:Antigens, Viral / Q000276:immunology; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D015848:Interleukin-5 / Q000378:metabolism; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D000076222:Mechanistic Target of Rapamycin Complex 1 / Q000378:metabolism; D008875:Middle Aged; D012136:Respiratory Syncytial Viruses / Q000276:immunology*; D019893:Ribosomal Protein S6 Kinases / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D020123:Sirolimus / Q000627:therapeutic use*; D018418:Th2 Cells / Q000276:immunology*; D055815:Young Adult
chemical_list: D039741:Antigens, Dermatophagoides; D000956:Antigens, Viral; C508599:IL5 protein, human; D007166:Immunosuppressive Agents; D015848:Interleukin-5; D000076222:Mechanistic Target of Rapamycin Complex 1; D019893:Ribosomal Protein S6 Kinases; D020123:Sirolimus