title: Selective Blockade of α2-Adrenoceptor Subtypes Modulates Contractility of Rat Myocardium.
abstract: The study examined the dose-dependent effects of selective antagonists of α2A/D-, α2B-, and α2C- adrenoceptors applied in concentrations of 10-9-10-5M on atrial and ventricular contractility of rat myocardium in vitro. Selective blockade of each α2-adrenoceptor subtype affected the contractile force of the atrial and ventricular strips. Various concentrations of α2A/D- and α2C-adrenoceptor antagonists produced positive inotropic effect on ventricular strips and negative effect on atrial strips. α2B-Adrenoceptor blocker in the majority of the tested concentrations produced a positive inotropic effect in both atria and ventricles.
authors.affiliation: Department of Anatomy, Physiology, and Human Health Protection, Kazan (Volga Region) Federal University, Kazan, the Republic of Tatarstan, Russia. zefirovtl@mail.ru.
authors.forename: T L
authors.initials: TL
authors.lastname: Zefirov
authors.affiliation: Department of Anatomy, Physiology, and Human Health Protection, Kazan (Volga Region) Federal University, Kazan, the Republic of Tatarstan, Russia.
authors.forename: L I
authors.initials: LI
authors.lastname: Khisamieva
authors.affiliation: Department of Anatomy, Physiology, and Human Health Protection, Kazan (Volga Region) Federal University, Kazan, the Republic of Tatarstan, Russia.
authors.forename: N I
authors.initials: NI
authors.lastname: Ziyatdinova
authors.affiliation: Department of Normal Physiology, Kazan State Medical University, Kazan, the Republic of Tatarstan, Russia.
authors.forename: A L
authors.initials: AL
authors.lastname: Zefirov
mesh_terms: D000166:Acridines / Q000494:pharmacology*; D058669:Adrenergic alpha-2 Receptor Antagonists / Q000494:pharmacology*; D000818:Animals; D021461:Animals, Outbred Strains; D004305:Dose-Response Relationship, Drug; D006325:Heart Atria / Q000187:drug effects; D006352:Heart Ventricles / Q000187:drug effects; D019329:Idazoxan / Q000031:analogs & derivatives* / Q000494:pharmacology; D007093:Imidazoles / Q000494:pharmacology*; D009200:Myocardial Contraction / Q000187:drug effects* / Q000502:physiology; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D018341:Receptors, Adrenergic, alpha-2 / Q000145:classification / Q000378:metabolism*; D046509:Tissue Culture Techniques
chemical_list: D000166:Acridines; D058669:Adrenergic alpha-2 Receptor Antagonists; D007093:Imidazoles; C518829:JP-1302; D010879:Piperazines; D018341:Receptors, Adrenergic, alpha-2; C058525:2-methoxyidazoxan; D019329:Idazoxan; C044484:Imiloxan
keywords: chronotropy; heart; rat; α2-adrenoceptor