title: Chikungunya Pathogenesis: From the Clinics to the Bench.
abstract: Chikungunya alphavirus has caused large epidemics worldwide and leads to acute incapacitating polyarthralgia. The inflammatory reaction over several days will drive robust innate and humoral responses essential to control the infection. Critically, fatal cases and mother-to-child transmission have also been described. Chikungunya can give rise to chronic musculoskeletal diseases, which can last for months to years, particularly in elderly individuals, and occasionally leads to seronegative rheumatoid arthritis-like pathologies. Histopathological studies of patient biopsy specimens and animal models have revealed that chikungunya virus can hide in tissue sanctuaries, and ongoing research should help to decipher the inflammatory mechanisms of tissue injuries.
authors.affiliation: UMR PIMIT, Processus Infectieux en Milieu Insulaire Tropical Université de La Réunion, INSERM U1187, CNRS 9192, IRD 249, St. Denis, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Gasque
authors.affiliation: UMR PIMIT, Processus Infectieux en Milieu Insulaire Tropical Université de La Réunion, INSERM U1187, CNRS 9192, IRD 249, St. Denis, France.
authors.forename: Marie Christine Jaffar
authors.initials: MC
authors.lastname: Bandjee
authors.affiliation: National Health Institute, Public Health Research Division, Bogotá.
authors.forename: Marcela Mercado
authors.initials: MM
authors.lastname: Reyes
authors.affiliation: Division of Health Sciences, Faculty of Medicine, Universidad del Norte and Hospital Universidad del Norte, Barranquilla, Colombia.
authors.forename: Diego
authors.initials: D
authors.lastname: Viasus
mesh_terms: D000368:Aged; D000818:Animals; D018771:Arthralgia / Q000276:immunology / Q000821:virology; D001172:Arthritis, Rheumatoid / Q000821:virology; D035843:Biomedical Research; D065632:Chikungunya Fever / Q000150:complications / Q000453:epidemiology* / Q000276:immunology / Q000821:virology*; D002646:Chikungunya virus / Q000472:pathogenicity*; D002908:Chronic Disease; D004195:Disease Models, Animal; D004660:Encephalitis / Q000821:virology; D058872:Epidemics; D006801:Humans; D056724:Immunity, Humoral; D007113:Immunity, Innate; D007249:Inflammation / Q000821:virology
keywords: alphavirus; arthritis; encephalitis; inflammation; innate immunity; polyarthralgia