title: Diagnostic and prognostic value of miR-106a in colorectal cancer.
abstract: We sought to systematically evaluate the diagnostic and prognostic value miR106a in patients with colorectal cancer (CRC). An original study was conducted to explore correlations between tissue miR106a levels and outcomes for 138 patients diagnosed with CRC. To explore the diagnostic performance of miR106a, eligible studies were identified from medical databases from China and abroad. Based on these results, 15 studies (including our original study) were pooled and included in a meta-analyses. The pooled sensitivity, specificity, and diagnostic odds ratios of miR106a were 0.53 (95% confidence interval (CI): 0.49-0.57), 0.85 (95% CI: 0.82-0.88), and 7.22 (95% CI: 3.17-16.44) for diagnosis of CRC, and the area under the curve (AUC) for miR106a when diagnosing CRC was 0.72. Patients with higher expression of tissue miR106a had poor overall survival (pooled hazard ratio (HR): 1.50; 95% CI: 1.02-2.20), but not disease-free survival (pooled HR: 1.03; 95% CI: 0.40-2.65). Overexpression of miR106a may predict superior metastasis-free survival (pooled HR: 0.65; 95% CI: 0.33-1.27), but the effect was not significant in this study (p = 0.21).
authors.affiliation: Department of General Surgery, Second Affiliated Hospital of Nanchang University, Nanchang, China.
authors.forename: Haibin
authors.initials: H
authors.lastname: Hao
authors.affiliation: Department of General Surgery, Second Affiliated Hospital of Nanchang University, Nanchang, China.
authors.forename: Laipeng
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of General Surgery, Second Affiliated Hospital of Nanchang University, Nanchang, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Zhang
authors.affiliation: Department of General Surgery, Second Affiliated Hospital of Nanchang University, Nanchang, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of General Surgery, Second Affiliated Hospital of Nanchang University, Nanchang, China.
authors.forename: Guangfeng
authors.initials: G
authors.lastname: Xia
authors.affiliation: Department of General Surgery, Second Affiliated Hospital of Nanchang University, Nanchang, China.
authors.forename: Fuping
authors.initials: F
authors.lastname: Zhong
authors.affiliation: Department of General Surgery, Second Affiliated Hospital of Nanchang University, Nanchang, China.
authors.forename: Xiaoyun
authors.initials: X
authors.lastname: Hu
mesh_terms: D019540:Area Under Curve; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D009367:Neoplasm Staging; D016017:Odds Ratio; D011379:Prognosis; D012680:Sensitivity and Specificity; D016019:Survival Analysis
chemical_list: C542541:MIRN106 microRNA, human; D035683:MicroRNAs
keywords: CRC; colorectal cancer; diagnosis; miR106a; prognosis