title: Total oxidative and anti-oxidative status, and ADAMTS-12 levels in placenta previa and early-onset severe preeclampsia.
abstract: OBJECTIVE
  This study was carried out due to the discussions in the literature stating that the inverse association between placenta previa (PP) and preeclampsia (PE). The aim of this study was to determine whether total antioxidant status (TAS), and total oxidant status (TOS) and ADAMTS-12 levels differ among early-onset (<34th gestational week) severe PE (EOS-PE), PP and uncomplicated pregnancies.
  
  
  METHODS
  In this case-control study, serum samples obtained from 26 pregnant with EOS-PE, 31 pregnant with PP, and 32 healthy patients with uncomplicated pregnancies (control group).
  
  
  RESULTS
  TOS levels were significantly higher in the EOS-PE than in the control group and PP groups (p=0.002, p=0.05, respectively). TAS levels were significantly lower in the EOS-PE than in the control (p<0.001). Although TAS levels were lower in the EOS-PE group than in the PP group, the differences were not statistically significant (p=0.09). There were no significant differences in the ADAMTS-12 levels of the groups.
  
  
  CONCLUSIONS
  The data in this study suggested that the balance between oxidative and anti-oxidative substances were comparable and normal in pregnancies complicated by PP when compared to normal pregnancies without placentation abnormality. In support of this, we encountered no case with PE and fetal growth restriction in our study groups suggesting normal placental angiogenesis. Contrarily, EOS-PE was associated with decreased TAS and increased TOS levels in the maternal serum.
authors.affiliation: Department of Perinatology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey. Electronic address: drayse1982@yahoo.com.
authors.forename: Ayse
authors.initials: A
authors.lastname: Kirbas
authors.affiliation: Department of Perinatology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
authors.forename: Korkut
authors.initials: K
authors.lastname: Daglar
authors.affiliation: Department of Perinatology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
authors.forename: Gulenay
authors.initials: G
authors.lastname: Gencosmanoglu
authors.affiliation: Department of Perinatology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
authors.forename: Zehra
authors.initials: Z
authors.lastname: Yilmaz
authors.affiliation: Department of Perinatology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Timur
authors.affiliation: Department of Obstetrics and Gynecology, Konya Education and Research Hospital, Konya, Turkey.
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Inal
authors.affiliation: Department of Perinatology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
authors.forename: Aykan
authors.initials: A
authors.lastname: Yucel
authors.affiliation: Department of Perinatology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
authors.forename: Nuri
authors.initials: N
authors.lastname: Danisman
mesh_terms: D000071096:ADAMTS Proteins / Q000097:blood*; D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D001794:Blood Pressure; D016022:Case-Control Studies; D005260:Female; D005865:Gestational Age; D006801:Humans; D010084:Oxidation-Reduction; D010923:Placenta Previa / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood* / Q000503:physiopathology; D011247:Pregnancy; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D000975:Antioxidants; D000071096:ADAMTS Proteins; C496252:ADAMTS12 protein, human
keywords: Matrix metalloproteinase; Oxidative stress; Placenta; Preeclampsia; Trophoblast