title: Two Cases of Suspected Rejection of Polydimethylsiloxane Urethral Bulking Agent.
abstract: We report the cases of 2 women who had urethral bulking injections with polydimethylsiloxane for stress urinary incontinence with intrinsic sphincter deficiency and reported initial improvement of symptoms followed by rapid return of stress urinary incontinence several weeks later associated with extrusion of the bulking material. We hypothesize this unique adverse outcome could represent immune rejection of this urethral bulking agent.
authors.affiliation: From the Department of Reproductive Medicine, University of California, San Diego, San Diego, CA.
authors.forename: Alaina Town
authors.initials: AT
authors.lastname: Bennett
authors.forename: Emily Spencer
authors.initials: ES
authors.lastname: Lukacz
mesh_terms: D000368:Aged; D004129:Dimethylpolysiloxanes / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D007267:Injections; D012008:Recurrence; D012826:Silicone Elastomers / Q000008:administration & dosage*; D017211:Treatment Failure; D016896:Treatment Outcome; D014521:Urethra / Q000503:physiopathology*; D014550:Urinary Incontinence, Stress / Q000175:diagnosis / Q000628:therapy*
chemical_list: D004129:Dimethylpolysiloxanes; D012826:Silicone Elastomers; C013830:baysilon