title: Multi-dimensional analysis on Parkinson's disease questionnaire-39 in Parkinson's patients treated with Bushen Huoxue Granule: A multicenter, randomized, double-blinded and placebo controlled trial.
abstract: OBJECTIVE
  To preliminarily assess the effects of Bushen Huoxue Granule (BHG) on Parkinson's Patients with Parkinson's Disease Questionnaire-39 (PDQ-39)and to provide data for further research.
  
  
  METHODS
  A randomized, double-blinded, placebo controlled study with a 3-month intervention period and a 6-month follow-up.
  
  
  METHODS
  Participants were patients with Parkinson's Disease (PD) of age ranging from 50 to 80 years and Hoehn and Yahr (H-Y) stage I-IV of the disease.120 participants were allocated to BHG group or placebo group at a 1:1 ratio. The BHG group received BHG twice a day for 3 months, and was followed-up for 6 months after treatment; the placebo group did not receive any Chinese Herb treatment for 9 months. All the patients were given the conventional therapy of levodopa (Madopar).
  
  
  METHODS
  Primary outcome measure was PDQ-39 comprises 39 questions with five different options of answer related to the frequency of the disease manifestation.
  
  
  RESULTS
  Significant statistical difference appeared in the following PDQ-39 dimensions: mobility; emotional well-being; stigma; cognition (P<0.01) and bodily discomfort (P<0.05).There was no statistical difference in the dimensions of social support, ADL and communication between the data of these two group patients (P≥0.05). We found that the sum index of PDQ-39 was significantly different between two groups.
  
  
  CONCLUSIONS
  The results of this study show that BHG treatment makes significant effects in most domains of PD patients life quality,especially in mobility, emotional well-being, stigma and cognition. The affected factors should be confirmed in larger studies.
authors.affiliation: Institute o f Traditional Chinese Medicine, General Hospital of People s Liberation Army, Beijing 100853, China. Electronic address: kittenlee1115@126.com.
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.affiliation: Institute o f Traditional Chinese Medicine, General Hospital of People s Liberation Army, Beijing 100853, China.
authors.forename: Hui Ming
authors.initials: HM
authors.lastname: Yang
authors.affiliation: Department of Internal Medicine, Guang dong Provincial Hospital of Traditional Chinese Medicine, Guang zhou 510310, Guang dong Province, China.
authors.forename: Dong Xiao
authors.initials: DX
authors.lastname: Luo
authors.affiliation: Department of Internal Medicine, Guang dong Provincial Hospital of Traditional Chinese Medicine, Guang zhou 510310, Guang dong Province, China.
authors.forename: Jian Zong
authors.initials: JZ
authors.lastname: Chen
authors.affiliation: Department of Traditional Chinese Medicine, Xijing Hospital, Forth Military Medical University, Xi an 710032, Shaanxi Provine, China.
authors.forename: Heng Jun
authors.initials: HJ
authors.lastname: Shi
mesh_terms: D000368:Aged; D004311:Double-Blind Method; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000188:drug therapy*; D011788:Quality of Life; D011795:Surveys and Questionnaires
chemical_list: D004365:Drugs, Chinese Herbal; C527851:bushen huoxue
keywords: Bushen Huoxue Granule (BHG); Parkinson's disease; Parkinson's disease Questionnaire -39(PDQ-39)