title: Loss of the Opa interacting protein 5 inhibits breast cancer proliferation through miR-139-5p/NOTCH1 pathway.
abstract: Opa interacting protein 5 (OIP5) has been reported to be over-expressed in several kinds of human cancer. However, the biological function and clinical significance of OIP5 in human breast cancer remains unknown. In this study, we found that OIP5 was notably over-expressed in breast cancer tissues compared with their corresponding nontumorous tissues. Statistical analysis showed a significant correlation of OIP5 expression with advanced clinical stage. Ablation OIP5 inhibited the proliferation of breast cancer cells. OIP5 over-expression inhibited hsa-miR-139-5p expression, antagonized its functions and led to the de-repression of its endogenous target NOTCH1, which was a core oncogene in promoting breast cancer progression. Our results suggested that OIP5 is a potential diagnosis biomarker and therapeutic target for breast cancer.
authors.affiliation: Department of General Surgery, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, PR China.
authors.forename: Hong-Chang
authors.initials: HC
authors.lastname: Li
authors.affiliation: Department of General Surgery, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, PR China.
authors.forename: Ya-Feng
authors.initials: YF
authors.lastname: Chen
authors.affiliation: Department of General Surgery, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, PR China.
authors.forename: Wen
authors.initials: W
authors.lastname: Feng
authors.affiliation: Department of General Surgery, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, PR China.
authors.forename: Han
authors.initials: H
authors.lastname: Cai
authors.affiliation: Department of General Surgery, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, PR China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Mei
authors.affiliation: Department of General Surgery, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, PR China.
authors.forename: Yi-Ming
authors.initials: YM
authors.lastname: Jiang
authors.affiliation: Department of General Surgery, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, PR China.
authors.forename: Teng
authors.initials: T
authors.lastname: Chen
authors.affiliation: Central Laboratory of Putuo Hospital, Interventional Cancer Institute of Chinese Integrative Medicine, Shanghai University of Traditional Chinese Medicine, 164 Lanxi Rd, Shanghai 200062, PR China. Electronic address: cola519@163.com.
authors.forename: Ke
authors.initials: K
authors.lastname: Xu
authors.affiliation: Department of General Surgery, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, PR China. Electronic address: fdianxu@sohu.com.
authors.forename: Dian-Xu
authors.initials: DX
authors.lastname: Feng
mesh_terms: D000328:Adult; D017209:Apoptosis; D001483:Base Sequence; D014408:Biomarkers, Tumor / Q000235:genetics* / Q000378:metabolism; D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D018797:Cell Cycle Proteins; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002470:Cell Survival; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics* / Q000378:metabolism; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D008867:Microtomy; D008875:Middle Aged; D016612:Paraffin Embedding; D034741:RNA, Small Interfering / Q000235:genetics* / Q000378:metabolism; D051881:Receptor, Notch1 / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction; D016019:Survival Analysis
chemical_list: D014408:Biomarkers, Tumor; D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; C555098:MIRN139 microRNA, human; D035683:MicroRNAs; C497761:NOTCH1 protein, human; C517146:OIP5 protein, human; D034741:RNA, Small Interfering; D051881:Receptor, Notch1
keywords: Breast cancer; NOTCH1; OIP5; Proliferation; miR-139-5p