title: Inflammatory Bowel Disease Meets Systems Biology: A Multi-Omics Challenge and Frontier.
abstract: The inflammatory bowel disease (IBD) is a systemic disease that is characterized by the inflammation of the gastrointestinal tract. It includes ulcerative colitis and the Crohn's disease. Presently, IBD is one of the most investigated common complex human disorders, although its causes remain unclear. Multi-omics mechanisms involving genomic, transcriptomic, proteomic, and epigenomic variations, not to forget the miRNome, together with environmental contributions, result in an impairment of the immune system in persons with IBD. Such interactions at multiple levels of biology and in concert with the environment constitute the actual engine of this complex disease, demanding a multifactorial and multi-omics perspective to better understand the root causes of IBD. This expert analysis reviews and examines the latest literature and underscores, from the perspective of systems biology, the value of multi-omics technologies as opportunities to unravel the "IBD integrome." We anticipate that multi-omics research will accelerate the new discoveries and insights on IBD in the near future. It shall also pave the way for early diagnosis and help clinicians and families with IBD to forecast and make informed decisions about the prognosis and, possibly, personalized therapeutics in the future.
authors.affiliation: 1 Division of Gastroenterology, IRCCS "Casa Sollievo della Sofferenza" Hospital , San Giovanni Rotondo, Italy .
authors.forename: Orazio
authors.initials: O
authors.lastname: Palmieri
authors.affiliation: 2 Laboratory of Bioinformatics, IRCCS "Casa Sollievo della Sofferenza" Hospital , San Giovanni Rotondo, Italy .
authors.forename: Tommaso
authors.initials: T
authors.lastname: Mazza
authors.affiliation: 2 Laboratory of Bioinformatics, IRCCS "Casa Sollievo della Sofferenza" Hospital , San Giovanni Rotondo, Italy .
authors.forename: Stefano
authors.initials: S
authors.lastname: Castellana
authors.affiliation: 1 Division of Gastroenterology, IRCCS "Casa Sollievo della Sofferenza" Hospital , San Giovanni Rotondo, Italy .
authors.forename: Anna
authors.initials: A
authors.lastname: Panza
authors.affiliation: 1 Division of Gastroenterology, IRCCS "Casa Sollievo della Sofferenza" Hospital , San Giovanni Rotondo, Italy .
authors.forename: Tiziana
authors.initials: T
authors.lastname: Latiano
authors.affiliation: 1 Division of Gastroenterology, IRCCS "Casa Sollievo della Sofferenza" Hospital , San Giovanni Rotondo, Italy .
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Corritore
authors.affiliation: 1 Division of Gastroenterology, IRCCS "Casa Sollievo della Sofferenza" Hospital , San Giovanni Rotondo, Italy .
authors.forename: Angelo
authors.initials: A
authors.lastname: Andriulli
authors.affiliation: 1 Division of Gastroenterology, IRCCS "Casa Sollievo della Sofferenza" Hospital , San Giovanni Rotondo, Italy .
authors.forename: Anna
authors.initials: A
authors.lastname: Latiano
mesh_terms: D023281:Genomics / Q000379:methods; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000235:genetics / Q000378:metabolism*; D055432:Metabolomics / Q000379:methods; D040901:Proteomics / Q000379:methods; D049490:Systems Biology / Q000379:methods*
keywords: IBD; genomics; metabolomics; metagenomics; metylomics; proteomics