title: Retinal nerve fiber layer thickness in a healthy Turkish population measured by optical coherence tomography.
abstract: BACKGROUND
  Normative optical coherence tomography (OCT) data is required for different subsets of the population as ethnic differences in retinal nerve fiber layer (RNFL) thickness have been reported. An OCT database for the normal Turkish population is not commercially available.
  
  
  OBJECTIVE
  Quantify peripapillary RNFL thickness in a Turkish population.
  
  
  METHODS
  Cross-sectional, descriptive study.
  
  
  METHODS
  Numune Training and Research Hospital, Adana, Turkey.
  
  
  METHODS
  RNFL measurements performed by Spectral OCT with a circular scan with 3.4 mm circle were centered around the optic disc of the right eye of each subject. Correlation of the effects of age and gender on RNFL thickness was analyzed.
  
  
  METHODS
  Correlation and measurements of RNFL. Retinal nerve fiber layer thick- ness measurements were obtained for the entire circumference of the optic nerve head.
  
  
  RESULTS
  In 307 healthy subjects consisting of 135 (44%) males and 172 (56%) females, with a mean (SD) age of 35.1 (9.6) years (range, 20-50 years), RNFL was superior: 132.2 (16.63) micro m, inferior: 139.1 (14.53) micro m, nasal: 96.2 (14.23) micro m, temporal: 79.8 (10.7) micro m. The mean (SD) RNFL thickness for the group was 111.5 (9.3) micro m. There was no significant difference between the average RNFL thicknesses of age groups nor between males and females (P=.1, P=.42), and no significant correlation with respect to age (P=.430, r=-.04). There was a statistically significant difference between the inferior quadrants of the two genders (P=.04).
  
  
  CONCLUSIONS
  RNFL thickness did not vary significantly with gender. A weak negative but statistically nonsignificant correlation between average RNFL thickness and age was found.
  
  
  CONCLUSIONS
  The participants were young adults or at early middle age so age effects on RNFL thickness may not be explained. The data does not reflect the entire Turkish population, which is not homogeneous.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Cubuk
authors.forename: Nedime
authors.initials: N
authors.lastname: Sahinoglu-Keskek
authors.affiliation: Sakir Ozgur Keskek, Department of Internal Medicine,, Adana Numune Egitim ve Arastirma Hastanesi,, Adana, Turkey, T: +903223550101, F: +903223550105, drkeskek@yahoo.com, ORCID: http://orcid.org/0000-0001-5888-3123.
authors.forename: Sakir Ozgur
authors.initials: SO
authors.lastname: Keskek
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers; D009898:Optic Disk / Q000000981:diagnostic imaging*; D012160:Retina / Q000000981:diagnostic imaging*; D041623:Tomography, Optical Coherence; D014421:Turkey; D055815:Young Adult