title: Long-Term Task- and Dopamine-Dependent Dynamics of Subthalamic Local Field Potentials in Parkinson's Disease.
abstract: Subthalamic nucleus (STN) local field potentials (LFP) are neural signals that have been shown to reveal motor and language behavior, as well as pathological parkinsonian states. We use a research-grade implantable neurostimulator (INS) with data collection capabilities to record STN-LFP outside the operating room to determine the reliability of the signals over time and assess their dynamics with respect to behavior and dopaminergic medication. Seven subjects were implanted with the recording augmented deep brain stimulation (DBS) system, and bilateral STN-LFP recordings were collected in the clinic over twelve months. Subjects were cued to perform voluntary motor and language behaviors in on and off medication states. The STN-LFP recorded with the INS demonstrated behavior-modulated desynchronization of beta frequency (13-30 Hz) and synchronization of low gamma frequency (35-70 Hz) oscillations. Dopaminergic medication did not diminish the relative beta frequency oscillatory desynchronization with movement. However, movement-related gamma frequency oscillatory synchronization was only observed in the medication on state. We observed significant inter-subject variability, but observed consistent STN-LFP activity across recording systems and over a one-year period for each subject. These findings demonstrate that an INS system can provide robust STN-LFP recordings in ambulatory patients, allowing for these signals to be recorded in settings that better represent natural environments in which patients are in a variety of medication states.
authors.affiliation: Colorado Neurological Institute, Englewood, CO 80113, USA. shanrahan@thecni.org.
authors.forename: Sara J
authors.initials: SJ
authors.lastname: Hanrahan
authors.affiliation: Colorado Neurological Institute, Englewood, CO 80113, USA. jnedrud@thecni.org.
authors.forename: Joshua J
authors.initials: JJ
authors.lastname: Nedrud
authors.affiliation: Department of Mechanical and Materials Engineering, University of Denver, Denver, CO 80208, USA. Bradley.Davidson@du.edu.
authors.forename: Bradley S
authors.initials: BS
authors.lastname: Davidson
authors.affiliation: Movement and Neuroperformance Center of Colorado, Englewood, CO 80113, USA. sierrafarris@gmail.com.
authors.forename: Sierra
authors.initials: S
authors.lastname: Farris
authors.affiliation: Movement and Neuroperformance Center of Colorado, Englewood, CO 80113, USA. giroux_ml@yahoo.com.
authors.forename: Monique
authors.initials: M
authors.lastname: Giroux
authors.affiliation: Blue Sky Neurology, Englewood, CO 80113, USA. aaronhaug@gmail.com.
authors.forename: Aaron
authors.initials: A
authors.lastname: Haug
authors.affiliation: Department of Electrical and Computer Engineering, University of Denver, CO 80208, USA. Mohammad.Mahoor@du.edu.
authors.forename: Mohammad H
authors.initials: MH
authors.lastname: Mahoor
authors.affiliation: Department of Mechanical Engineering, Colorado School of Mines, Golden, CO 80401, USA. asilverm@mines.edu.
authors.forename: Anne K
authors.initials: AK
authors.lastname: Silverman
authors.affiliation: Department of Electrical and Computer Engineering, University of Denver, CO 80208, USA. Jun.Zhang@du.edu.
authors.forename: Jun Jason
authors.initials: JJ
authors.lastname: Zhang
authors.affiliation: Colorado Neurological Institute, Englewood, CO 80113, USA. adam.hebb@aoh.md.
authors.forename: Adam Olding
authors.initials: AO
authors.lastname: Hebb
keywords: Parkinson’s disease (PD); beta frequency oscillations; closed-loop; deep brain stimulation (DBS); local field potential (LFP); subthalamic nucleus