title: Myeloid-derived suppressor cells and their role in pancreatic cancer.
abstract: Pancreatic cancer is a devastating disease and ranks as the third most common cause of cancer-related death. Like many cancers, there has been increased interest in the role of the immune system in the progression and development of pancreatic cancer. In particular, immunosuppression within the tumor microenvironment (TME) is thought to impair the host's antitumor response. In this article, we review myeloid-derived suppressor cells and their contribution to this immunosuppression within the pancreatic TME.
authors.affiliation: Department of Cell Biology, S. Arthur Localio Laboratory, New York University School of Medicine, New York, NY, USA.
authors.forename: M
authors.initials: M
authors.lastname: Pergamo
authors.affiliation: Department of Cell Biology, S. Arthur Localio Laboratory, New York University School of Medicine, New York, NY, USA.
authors.forename: G
authors.initials: G
authors.lastname: Miller
mesh_terms: D000818:Animals; D021441:Carcinoma, Pancreatic Ductal / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D002450:Cell Communication; D002465:Cell Movement / Q000276:immunology; D049109:Cell Proliferation; D006801:Humans; D007157:Immunologic Surveillance; D056747:Immunomodulation; D008264:Macrophages / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D058990:Molecular Targeted Therapy; D000072737:Myeloid-Derived Suppressor Cells / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism* / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000276:immunology* / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D010641:Phenotype; D015398:Signal Transduction; D059016:Tumor Microenvironment / Q000276:immunology