title: Palladium-Catalyzed Stereoselective Formation of Substituted Allylic Thioethers and Sulfones.
abstract: A general method is reported for the stereoselective preparation of highly functionalized allylic thioethers. This protocol is based on a Pd-catalyzed thiolation of modular vinyl cyclic carbonate substrates and features high (Z)-selectivity, good yields, minimal waste, ample product scope, and operational simplicity. A one-pot strategy was used for the stereoselective formation of pharma-relevant allylic sulfones derived from their in situ prepared thioether precursors.
authors.affiliation: Institute of Chemical Research of Catalonia (ICIQ), Barcelona Institute of Science and Technology , Av. Països Catalans 16, 43007 Tarragona, Spain.
authors.forename: José Enrique
authors.initials: JE
authors.lastname: Gómez
authors.affiliation: Institute of Chemical Research of Catalonia (ICIQ), Barcelona Institute of Science and Technology , Av. Països Catalans 16, 43007 Tarragona, Spain.
authors.forename: Wusheng
authors.initials: W
authors.lastname: Guo
authors.affiliation: Institute of Chemical Research of Catalonia (ICIQ), Barcelona Institute of Science and Technology , Av. Països Catalans 16, 43007 Tarragona, Spain.|Catalan Institute of Research and Advanced Studies (ICREA) , Pg. Lluís Companys 23, 08010 Barcelona, Spain.
authors.forename: Arjan W
authors.initials: AW
authors.lastname: Kleij