title: Correction of Negative Effect of Antenatal Hypoxia on Liver Tissue Homeostasis in Newborn Albino Rats with Opioid Peptides.
abstract: We studied the possibility of correction of the negative effects of antenatal hypoxia on the liver tissue homeostasis in 7-day-old albino rats by administration of opioid peptides in a dose of 100 μg/kg on postnatal days 2-6. Administration of mixed μ/δ-opioid receptor agonist Dalargin neutralized deviations of gravimetric indicators, parameters of proliferative activity, and activity of the nucleolar apparatus of hepatocytes. Administration of the non-opiate Leu-enkephalin analogue did not normalize gravimetric parameters and nucleolar apparatus parameters, however, it significantly increased the pool of proliferating hepatocytes. Both peptides significantly reduced the intensity of free radical oxidation, improved antioxidant antiradical defense and resistance to peroxidation in the liver tissue of animals subjected to antenatal hypoxia.
authors.affiliation: Far Eastern State Medical University, Ministry of Health of Russian Federation, Khabarovsk, Russia. pinaeva_og@mail.ru.
authors.forename: O G
authors.initials: OG
authors.lastname: Pinaeva
authors.affiliation: Far Eastern State Medical University, Ministry of Health of Russian Federation, Khabarovsk, Russia.|Khabarovsk Branch of the Far Eastern Center of Physiology and Pathology of Respiration - Research Institute of Maternity and Childhood, Khabarovsk, Russia.
authors.forename: E N
authors.initials: EN
authors.lastname: Sazonova
authors.affiliation: Far Eastern State Medical University, Ministry of Health of Russian Federation, Khabarovsk, Russia.|Khabarovsk Branch of the Far Eastern Center of Physiology and Pathology of Respiration - Research Institute of Maternity and Childhood, Khabarovsk, Russia.
authors.forename: O A
authors.initials: OA
authors.lastname: Lebed'ko
authors.affiliation: Far Eastern State Medical University, Ministry of Health of Russian Federation, Khabarovsk, Russia.
authors.forename: S S
authors.initials: SS
authors.lastname: Timoshin
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000975:Antioxidants / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D002467:Cell Nucleus / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D005609:Free Radicals / Q000037:antagonists & inhibitors; D022781:Hepatocytes / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D006706:Homeostasis / Q000187:drug effects; D000860:Hypoxia / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D018847:Opioid Peptides / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000975:Antioxidants; D005609:Free Radicals; D018847:Opioid Peptides; D016308:Enkephalin, Leucine-2-Alanine; C040996:enkephalin-Leu, Ala(2)-Arg(6)-
keywords: DNA synthesis; antenatal hypoxia; free radical oxidation; hepatocytes; opioid peptides