title: Using the BITOLA system to identify candidate molecules in the interaction between oral lichen planus and depression.
abstract: Exacerbations of oral lichen planus (OLP) have been linked to the periods of psychological stress, anxiety and depression. The specific mechanism of the interaction is unclear. The aim of this study was to explore the candidate genes or molecules that play important roles in the interaction between OLP and depression. The BITOLA system was used to search all intermediate concepts relevant to the "Gene or Gene Product" for OLP and depression, and the gene expression data and tissue-specific gene data along with manual checking were then employed to filter the intermediate concepts. Finally, two genes (NCAM1, neural cell adhesion molecule 1; CD4, CD4 molecule) passed the follow-up inspection. By using the text mining can formulate a new hypothesis: NCAM1 and CD4 were identified as involved or potentially involved in the interaction between OLP and depression. These results offer a new clue for the experimenters and hold promise for developing innovative therapeutic strategies for these two diseases.
authors.affiliation: Institute of Hard Tissue Development and Regeneration, The Second Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang, China.
authors.forename: Yuanbo
authors.initials: Y
authors.lastname: Zhan
authors.affiliation: Institute of Hard Tissue Development and Regeneration, The Second Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang, China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Zhou
authors.affiliation: Institute of Hard Tissue Development and Regeneration, The Second Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.affiliation: Institute of Hard Tissue Development and Regeneration, The Second Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang, China.
authors.forename: Sen
authors.initials: S
authors.lastname: Mu
authors.affiliation: Colleges of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150086, China.
authors.forename: Ruijie
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Department of Stomatology, The Central Hospital of Liaoyang City, Liaoyang 111000, China.
authors.forename: Xuejing
authors.initials: X
authors.lastname: Song
authors.affiliation: Institute of Hard Tissue Development and Regeneration, The Second Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Lin
authors.affiliation: Department of Periodontology and Oral Mucosa, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China. Electronic address: yzzhangrm@126.com.
authors.forename: Ruimin
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Institute of Hard Tissue Development and Regeneration, The Second Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang, China; Heilongjiang Academy of Medical Sciences, Harbin 150001, Heilongjiang, China. Electronic address: zhangbinyzz@126.com.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
mesh_terms: D001921:Brain / Q000378:metabolism*; D015704:CD4 Antigens / Q000235:genetics / Q000378:metabolism*; D019002:CD56 Antigen / Q000235:genetics / Q000378:metabolism*; D003863:Depression / Q000378:metabolism* / Q000473:pathology*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D017676:Lichen Planus, Oral / Q000378:metabolism*; D008297:Male; D012333:RNA, Messenger / Q000378:metabolism; D059467:Transcriptome / Q000502:physiology
chemical_list: D015704:CD4 Antigens; D019002:CD56 Antigen; C522918:NCAM1 protein, human; D012333:RNA, Messenger
keywords: Gene expression profiling; Mental disorders; Mouth diseases; Text mining