title: Genetics of inherited cardiocutaneous syndromes: a review.
abstract: The life of a human being originates as a single cell which, under the influence of certain factors, divides sequentially into multiple cells that subsequently become committed to develop and differentiate into the different structures and organs. Alterations occurring early on in the development process may lead to fetal demise in utero. Conversely, abnormalities at later stages may result in structural and/or functional abnormalities of varying severities. The cardiovascular system and skin share certain developmental and structural factors; therefore, it is not surprising to find several inherited syndromes with both cardiac and skin manifestations. Here, we will review the overlapping pathways in the development of the skin and heart, as well as the resulting syndromes. We will also highlight several cutaneous clues that may help physicians screen and uncover cardiac anomalies that may be otherwise hidden and result in sudden cardiac death.
authors.affiliation: American University of Beirut , Beirut Lebanon.
authors.forename: Tara
authors.initials: T
authors.lastname: Bardawil
authors.affiliation: American University of Beirut , Beirut Lebanon.
authors.forename: Samar
authors.initials: S
authors.lastname: Khalil
authors.affiliation: Department of Dermatology , American University of Beirut , Beirut Lebanon.
authors.forename: Christina
authors.initials: C
authors.lastname: Bergqvist
authors.affiliation: Department of Dermatology , American University of Beirut , Beirut Lebanon.
authors.forename: Ossama
authors.initials: O
authors.lastname: Abbas
authors.affiliation: Department of Dermatology , American University of Beirut , Beirut Lebanon.
authors.forename: Abdul Ghani
authors.initials: AG
authors.lastname: Kibbi
authors.affiliation: Department of Biochemistry and Molecular Genetics, American University of Beirut, BeirutLebanon; Department of Pediatrics, American University of Beirut, BeirutLebanon.
authors.forename: Fadi
authors.initials: F
authors.lastname: Bitar
authors.affiliation: Department of Biochemistry and Molecular Genetics , American University of Beirut , Beirut Lebanon.
authors.forename: Georges
authors.initials: G
authors.lastname: Nemer
authors.affiliation: Department of Dermatology, American University of Beirut, BeirutLebanon; Department of Biochemistry and Molecular Genetics, American University of Beirut, BeirutLebanon; Department of Dermatology, Columbia University Medical Center, New York, New York, USA.
authors.forename: Mazen
authors.initials: M
authors.lastname: Kurban
keywords: Cardiocutaneous; Congenital; Dermatologic; Syndromes