title: Single nucleotide polymorphism of adiponectin +276 G/T is associated with the susceptibility to essential hypertension in a Turkish population.
abstract: BACKGROUND
  It is well known that arterial stiffness is associated with hypertension. Recent studies have shown that adiponectin +276 G/T, ACE I/D, AGTR1 A1166C, and eNOS E298D polymorphisms are likely to be risk factors for arterial stiffness. In this study, we aimed to investigate possible associations between these single-nucleotide polymorphisms (SNPs) and essential hypertension in a Turkish population.
  
  
  METHODS
  The study population consisted of 170 patients who were diagnosed with essential hypertension and 170 sex- and age-matched controls. Genotyping of adiponectin +276 G/T, ACE I/D, AGTR1 A1166C, and eNOS E298D SNPs were performed using real-time polymerase chain reaction and commercially produced kits.
  
  
  RESULTS
  The percentage of the adiponectin +276 T allele carriers was significantly higher in the patients with hypertension (33%) than in the controls (25%, p < 0.011). Through multiple logistic regression analysis, the adiponectin +276 T allele carrier was found to be associated with an increased risk of hypertension (TT vs. GG and TG: odds ratio = 3.318, p = 0.014, 95% confidence interval: 1.269-8.678). The genotype distributions or allelic frequencies of ACE I/D, AGTR1 A1166C, and eNOS E298D SNPs did not significantly differ between the patients with hypertension and the controls.
  
  
  CONCLUSIONS
  The present study demonstrated that the adiponectin +276 G/T SNP is likely to be a risk factor for essential hypertension in a Turkish population.
authors.affiliation: a Department of Internal Medicine , Gaziosmanpasa University Faculty of Medicine , Tokat , Turkey.
authors.forename: Ayşe Kevser
authors.initials: AK
authors.lastname: Demir
authors.affiliation: a Department of Internal Medicine , Gaziosmanpasa University Faculty of Medicine , Tokat , Turkey.
authors.forename: Süheyla Uzun
authors.initials: SU
authors.lastname: Kaya
authors.affiliation: a Department of Internal Medicine , Gaziosmanpasa University Faculty of Medicine , Tokat , Turkey.
authors.forename: Şafak
authors.initials: Ş
authors.lastname: Şahin
authors.affiliation: b Department of Biochemistry , Gaziosmanpasa University Faculty of Medicine , Tokat , Turkey.
authors.forename: İsmail
authors.initials: İ
authors.lastname: Benli
authors.affiliation: b Department of Biochemistry , Gaziosmanpasa University Faculty of Medicine , Tokat , Turkey.
authors.forename: İlknur
authors.initials: İ
authors.lastname: Bütün
authors.affiliation: c Department of Nephrology , Gaziosmanpasa University Faculty of Medicine , Tokat , Turkey.
authors.forename: Ertuğrul
authors.initials: E
authors.lastname: Erken
authors.affiliation: a Department of Internal Medicine , Gaziosmanpasa University Faculty of Medicine , Tokat , Turkey.
authors.forename: Turker
authors.initials: T
authors.lastname: Tasliyurt
mesh_terms: D052242:Adiponectin / Q000235:genetics* / Q000378:metabolism; D004247:DNA / Q000235:genetics*; D000075222:Essential Hypertension; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism; D015994:Incidence; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D060888:Real-Time Polymerase Chain Reaction; D012307:Risk Factors; D014421:Turkey / Q000453:epidemiology
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D004247:DNA
keywords: Adiponectin; angiotensin II receptor 1; angiotensin-converting enzyme; arterial stiffness; endogenous nitric oxide synthase; essential hypertension; genetic polymorphism