title: Prenatal Iron Deficiency, Neonatal Ferritin, and Infant Cognitive Function.
abstract: To investigate the impact of prenatal maternal iron deficiency (ID) on cord blood serum ferritin (CBSF) concentration and infant cognitive and motor development.
  
  
  
  Our prospective cohort study included 636 mother-singleton child pairs from 828 eligible pregnant women who were enrolled during their first antenatal care (ANC) visit in Allada, Benin, into a clinical trial comparing the efficacy of mefloquine and sulfadoxine-pyrimethamine. Venous blood samples of women were assessed for ferritin and hemoglobin concentrations at the first and second ANC visits (occurring at least 1-month apart) and at delivery. Women were prescribed daily iron and folic acid supplements throughout pregnancy. Hematologic examinations were repeated for cord blood at birth. At age 1 year, cognitive and motor functions of children were assessed by using the Mullen Scales of Early Learning.
  
  
  
  The prevalence of prenatal ID at first and second ANC visits, and at delivery was 30.5%, 34.0%, and 28.4%, respectively. CBSF concentrations were similar between ID and non-ID pregnant women. Neither prenatal ID nor CBSF concentration was associated with poor cognitive or gross motor function of children at age 1 year. CBSF concentrations were lower among mothers who had ID anemia (IDA) at delivery compared with non-IDA pregnant women (adjusted mean difference: -0.2 [95% confidence interval: -0.4 to -0.0]).
  
  
  
  In a malaria-endemic region, ID in pregnancy in the context of iron supplementation is neither associated with CBSF concentration nor with infant cognitive and motor development. Prenatal IDA around the time of delivery is associated with lower CBSF concentrations.
authors.affiliation: Institut de Recherche pour le Développement (IRD), Mère et Enfant Face aux Infections Tropicales, Paris, France; michael.osei.mireku@gmail.com.|Université Pierre et Marie Curie, Ecole Doctorale Pierre Louis de Santé Publique, Paris, France.|Département Méthodes Quantitatives en Santé Publique, Ecole des Hautes Etudes en Santé Publique, Rennes, France.
authors.forename: Michael O
authors.initials: MO
authors.lastname: Mireku
authors.affiliation: Mailman School of Public Health and the College of Physicians and Surgeons, Columbia University, New York, New York.
authors.forename: Leslie L
authors.initials: LL
authors.lastname: Davidson
authors.affiliation: Departments of Psychiatry and Neurology/Ophthalmology, Michigan State University, East Lansing, Michigan.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Boivin
authors.affiliation: Faculté des Sciences de la Santé, Université d'Abomey-Calavi, Cotonou, Bénin.
authors.forename: Romeo
authors.initials: R
authors.lastname: Zoumenou
authors.affiliation: Faculté des Sciences de la Santé, Université d'Abomey-Calavi, Cotonou, Bénin.
authors.forename: Achille
authors.initials: A
authors.lastname: Massougbodji
authors.affiliation: Institut de Recherche pour le Développement (IRD), Mère et Enfant Face aux Infections Tropicales, Paris, France.|PRES Sorbonne Paris Cité, Faculté des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes, Paris, France; and.
authors.forename: Michel
authors.initials: M
authors.lastname: Cot
authors.affiliation: Département Méthodes Quantitatives en Santé Publique, Ecole des Hautes Etudes en Santé Publique, Rennes, France.|Inserm UMR 1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team (Epopé), Center for Epidemiology and Statistics Sorbonne Paris Cité, DHU Risks in Pregnancy, Paris Descartes University, Paris, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Bodeau-Livinec
mesh_terms: D000328:Adult; D018798:Anemia, Iron-Deficiency / Q000150:complications / Q000453:epidemiology*; D001541:Benin / Q000453:epidemiology; D002657:Child Development; D003071:Cognition; D015331:Cohort Studies; D005260:Female; D005293:Ferritins / Q000097:blood*; D005312:Fetal Blood; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007231:Infant, Newborn; D007501:Iron / Q000097:blood; D000090463:Iron Deficiencies; D008297:Male; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood / Q000453:epidemiology*; D011295:Prenatal Care; D011446:Prospective Studies; D055815:Young Adult
chemical_list: D006454:Hemoglobins; D005293:Ferritins; D007501:Iron