title: Reliability of basal plasma vasopressin concentrations in healthy male adults.
abstract: OBJECTIVE
  The neuropeptides oxytocin (OT) and arginine vasopressin (AVP) play important and interrelated roles in modulating mammalian social behaviour. While the OT system has received considerable research attention for its potential to treat psychiatric symptoms, comparatively little is known about the role of the AVP system in human social behaviour. To better understand the intraindividual stability of basal AVP, the present study assessed the reproducibility of basal plasma AVP concentrations.
  
  
  METHODS
  Basal plasma AVP was assessed at four sampling points separated by 8 days, on average, in 16 healthy adult males.
  
  
  RESULTS
  Only one out of six comparisons revealed strong evidence for reproducibility of basal AVP concentrations (visit 2 vs. visit 4: r=0.8, p0.1). The concordance correlation coefficient [0.15, 95% CI (-0.55, 0.73)] also revealed poor overall reproducibility.
  
  
  CONCLUSIONS
  Poor reliability of basal AVP concentrations suggests future work covarying AVP with trait markers should proceed with careful consideration of intraindividual fluctuations.
authors.affiliation: 1NORMENT KG Jebsen Centre for Psychosis Research,Division of Mental Health and Addiction,Institute of Clinical Medicine,Oslo University Hospital,University of Oslo,Oslo,Norway.
authors.forename: Daniel S
authors.identifier: http://orcid.org/0000-0003-2876-0004
authors.initials: DS
authors.lastname: Quintana
authors.affiliation: 1NORMENT KG Jebsen Centre for Psychosis Research,Division of Mental Health and Addiction,Institute of Clinical Medicine,Oslo University Hospital,University of Oslo,Oslo,Norway.
authors.forename: Lars T
authors.initials: LT
authors.lastname: Westlye
authors.affiliation: 3Smerud Medical Research International AS,Oslo,Norway.
authors.forename: Knut T
authors.initials: KT
authors.lastname: Smerud
authors.affiliation: 4OptiNose US Inc.,Yardley,PA,USA.
authors.forename: Ramy A
authors.initials: RA
authors.lastname: Mahmoud
authors.affiliation: 5OptiNose AS,Oslo,Norway.
authors.forename: Per G
authors.initials: PG
authors.lastname: Djupesland
authors.affiliation: 1NORMENT KG Jebsen Centre for Psychosis Research,Division of Mental Health and Addiction,Institute of Clinical Medicine,Oslo University Hospital,University of Oslo,Oslo,Norway.
authors.forename: Ole A
authors.initials: OA
authors.lastname: Andreassen
mesh_terms: D000328:Adult; D001127:Arginine Vasopressin / Q000097:blood*; D006801:Humans; D008297:Male; D015203:Reproducibility of Results; D055815:Young Adult
chemical_list: D001127:Arginine Vasopressin
keywords: endocrinology; neuropeptides; oxytocin; vasopressin