title: Clinical features and prognostic factors of small cell lung cancer: A retrospective study in 148 patients.
abstract: To better understand the outcomes of small cell lung cancer (SCLC), we examined the clinical features and prognostic factors of SCLC in this study. A total of 148 patients who were diagnosed as having SCLC between January 2009 and December 2013 in Cancer Center of Union Hospital, Wuhan, China, were enrolled and their clinical features and prognostic factors were retrospectively analyzed. Log-rank test and Cox regression model were employed for analysis of prognostic factors. The 1- and 2-year overall survival (OS) rates were 59.7% and 25.7%, respectively, for limited disease (LD) patients whose median survival time (MST) was 16 months. The 1- and 2-year OS rates were 29.5% and 5.3%, respectively, for extensive disease (ED) patients whose MST was 10 months. The univariate analysis and multivariate analysis revealed that age, tumor stage, serum CEA and Ki-67 antigen were significantly correlated to the outcomes of SCLC, and they were significant prognostic factors for SCLC.
authors.affiliation: Cancer Center, Huazhong University of Science and Technology, Wuhan, 430022, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Cai
authors.affiliation: Department of Oncology, Huanggang Central Hospital, Huangang, 438000, China.
authors.forename: Hong-Lan
authors.initials: HL
authors.lastname: Luo
authors.affiliation: Cancer Center, Huazhong University of Science and Technology, Wuhan, 430022, China.
authors.forename: Xi-Can
authors.initials: XC
authors.lastname: Gao
authors.affiliation: Cancer Center, Huazhong University of Science and Technology, Wuhan, 430022, China.
authors.forename: Chun-Jin
authors.initials: CJ
authors.lastname: Xiong
authors.affiliation: Cancer Center, Huazhong University of Science and Technology, Wuhan, 430022, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Tong
authors.affiliation: Cancer Center, Huazhong University of Science and Technology, Wuhan, 430022, China.
authors.forename: Rui-Guang
authors.initials: RG
authors.lastname: Zhang
authors.affiliation: Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Cancer Center, Huazhong University of Science and Technology, Wuhan, 430022, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Wu
authors.affiliation: Cancer Center, Huazhong University of Science and Technology, Wuhan, 430022, China. xr.dong@gmail.com.
authors.forename: Xiao-Rong
authors.initials: XR
authors.lastname: Dong
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000097:blood; D008175:Lung Neoplasms / Q000097:blood / Q000453:epidemiology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D055752:Small Cell Lung Carcinoma / Q000097:blood / Q000453:epidemiology / Q000473:pathology*; D016019:Survival Analysis
chemical_list: D019394:Ki-67 Antigen
keywords: prognosis factor; small cell lung cancer; survival rate