title: Atypical Leydig Cell Tumor in Children: Report of 2 Cases.
abstract: Leydig cell tumors (LCTs) are rare cord-stromal tumors that may occur in testis or ovaries and may produce androgens or estrogens. The majority has been found in men between the ages of 20 and 60 years. Adults with androgen-secreting LCTs are usually asymptomatic; feminizing syndromes may result from the production of estradiol or the peripheral aromatization of testosterone. In children, LCTs usually present between 5 and 10 years of age with isosexual precocious pseudopuberty or gynecomastia. We report 2 cases of LCT in prepubertal boys presenting with advanced unilateral pubarche and testicular volume asymmetry. Both subjects had normal penis size for age; no axillary hair or other signs of puberty were present. Height velocity was normal, and bone age was coincident with chronological age. Androgen levels were normal, as well as estrogen, corticotropin, and cortisol concentration. Testicular ultrasound demonstrated a testicular mass. Histology examination revealed a well-differentiated LCT. This is the first report of 2 pediatric patients with LCT presenting with advanced pubarche in absence of systemic hyperandrogenism. We hypothesize that the neoplastic cells may locally produce high levels of androgens or androgen-like bioactivity molecules that are responsible for the clinical manifestation. We suggest that a testicular ultrasound should be obtained in all children presenting with unilateral pubarche, with or without hyperandrogenism.
authors.affiliation: Departments of Pediatrics, and chiara.mameli@unimi.it.
authors.forename: Chiara
authors.initials: C
authors.lastname: Mameli
authors.affiliation: Pediatric Surgery, Children's Hospital "V. Buzzi," University of Milan, Milan, Italy.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Selvaggio
authors.affiliation: Division of Infectious Diseases, Children's Hospital Los Angeles, Los Angeles, California; and.
authors.forename: Chiara
authors.initials: C
authors.lastname: Cerini
authors.affiliation: Human Pathology Unit, Department of Health Sciences, San Paolo Hospital, University of Milan, Milan, Italy.
authors.forename: Gaetano
authors.initials: G
authors.lastname: Bulfamante
authors.affiliation: Departments of Pediatrics, and.
authors.forename: Cristina
authors.initials: C
authors.lastname: Madia
authors.affiliation: Pediatric Surgery, Children's Hospital "V. Buzzi," University of Milan, Milan, Italy.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Riccipetitoni
authors.affiliation: Departments of Pediatrics, and.
authors.forename: Gian Vincenzo
authors.initials: GV
authors.lastname: Zuccotti
mesh_terms: D002648:Child; D006801:Humans; D007984:Leydig Cell Tumor / Q000473:pathology* / Q000601:surgery; D008297:Male; D011629:Puberty, Precocious / Q000209:etiology; D013736:Testicular Neoplasms / Q000473:pathology* / Q000601:surgery