title: Comparative immunoexpression of ICAM-1, TGF-β1 and ki-67 in periapical and residual cysts.
abstract: BACKGROUND
  This study compared the immunohistochemical expression of ki-67, transforming growth factor beta 1 (TGF-β1) and intercellular adhesion molecule-1 (ICAM-1) in inflammatory periapical cysts and residual cysts.
  
  
  METHODS
  The study sample was composed by 25 periapical cysts and 25 residual cysts and immunohistochemical reactions were carried out using antibodies directed against ICAM-1, TGF-β1 and ki-67. Clinical, radiological, gross, histological and immunohistochemical data were tabulated for descriptive and comparative analysis using the SPSS software and differences were considered statistically significant when p<0.05%.
  
  
  RESULTS
  There were no differences between the expression of ICAM-1 (p=0.239) and TGF-β1 (p=0.258) when comparing both groups. Ki-67 labeling index was higher in residual cysts compared to periapical cysts (p=0.017).
  
  
  CONCLUSIONS
  Results from the present study suggest that some specific inflammatory stimuli on residual cysts would modulate their mechanisms of etiopathogenesis, growing and repair.
authors.affiliation: Post Graduation Program in Dentistry, Estácio de Sá University, Av. Alfredo Baltazar da Silveira, 580 cobertura, CEP 22790-701, Recreio dos Bandeirantes, Rio de Janeiro/RJ, Brazil, ramoafop@yahoo.com.
authors.forename: R
authors.initials: R
authors.lastname: Martins
authors.forename: L
authors.initials: L
authors.lastname: Armada
authors.forename: T-C
authors.initials: TC
authors.lastname: Dos Santos
authors.forename: F-R
authors.initials: FR
authors.lastname: Pires
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis*; D019394:Ki-67 Antigen / Q000096:biosynthesis*; D008875:Middle Aged; D011842:Radicular Cyst / Q000276:immunology* / Q000378:metabolism* / Q000601:surgery; D053773:Transforming Growth Factor beta1 / Q000096:biosynthesis*
chemical_list: D019394:Ki-67 Antigen; D053773:Transforming Growth Factor beta1; D018799:Intercellular Adhesion Molecule-1