title: Analysis and compensation for the effect of the catheter position on image intensities in intravascular optical coherence tomography.
abstract: Intravascular optical coherence tomography (IVOCT) is an imaging technique that is used to analyze the underlying cause of cardiovascular disease. Because a catheter is used during imaging, the intensities can be affected by the catheter position. This work aims to analyze the effect of the catheter position on IVOCT image intensities and to propose a compensation method to minimize this effect in order to improve the visualization and the automatic analysis of IVOCT images. The effect of catheter position is modeled with respect to the distance between the catheter and the arterial wall (distance-dependent factor) and the incident angle onto the arterial wall (angle-dependent factor). A light transmission model incorporating both factors is introduced. On the basis of this model, the interaction effect of both factors is estimated with a hierarchical multivariant linear regression model. Statistical analysis shows that IVOCT intensities are significantly affected by both factors with p<0.001, as either aspect increases the intensity decreases. This effect differs for different pullbacks. The regression results were used to compensate for this effect. Experiments show that the proposed compensation method can improve the performance of the automatic bioresorbable vascular scaffold strut detection.
authors.affiliation: Leiden University Medical Center, Department of Radiology C2-S, Division of Image Processing, P.O. Box 9600, Leiden 2300 RC, The Netherlands.
authors.forename: Shengnan
authors.initials: S
authors.lastname: Liu
authors.affiliation: Leiden University Medical Center, Department of Radiology C2-S, Division of Image Processing, P.O. Box 9600, Leiden 2300 RC, The Netherlands.
authors.forename: Jeroen
authors.initials: J
authors.lastname: Eggermont
authors.affiliation: Leiden University Medical Center, Department of Medical Statistics and Bioinformatics, P.O. Box 9600, Leiden 2300 RC, The Netherlands.
authors.forename: Ron
authors.initials: R
authors.lastname: Wolterbeek
authors.affiliation: Leiden University Medical Center, Department of Radiology C2-S, Division of Image Processing, P.O. Box 9600, Leiden 2300 RC, The Netherlands.
authors.forename: Alexander
authors.initials: A
authors.lastname: Broersen
authors.affiliation: University of Southern Denmark, Institute of Forensic Medicine, Odense C 5000, Denmark.
authors.forename: Carol A G R
authors.initials: CA
authors.lastname: Busk
authors.affiliation: University College Lillebaelt, Conrad Research Center, Odense SØ 5220, Denmark.
authors.forename: Helle
authors.initials: H
authors.lastname: Precht
authors.affiliation: Leiden University Medical Center, Department of Radiology C2-S, Division of Image Processing, P.O. Box 9600, Leiden 2300 RC, The NetherlandseDelft University of Technology, Intelligent Systems Department, P.O. Box 5031, Delft 2600 GA, The Netherlands.
authors.forename: Boudewijn P F
authors.initials: BP
authors.lastname: Lelieveldt
authors.affiliation: Leiden University Medical Center, Department of Radiology C2-S, Division of Image Processing, P.O. Box 9600, Leiden 2300 RC, The Netherlands.
authors.forename: Jouke
authors.initials: J
authors.lastname: Dijkstra
mesh_terms: D001158:Arteries / Q000000981:diagnostic imaging / Q000601:surgery; D057785:Catheters; D057510:Endovascular Procedures / Q000295:instrumentation* / Q000379:methods; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008955:Models, Cardiovascular; D015607:Stents; D041623:Tomography, Optical Coherence / Q000295:instrumentation / Q000379:methods*