title: A rapid monitoring method for inorganic arsenic in rice flour using reversed phase-high performance liquid chromatography-inductively coupled plasma mass spectrometry.
abstract: A new rapid monitoring method by means of high performance liquid chromatography-inductively coupled plasma mass spectrometry (HPLC-ICP-MS) following the heat-assisted extraction was developed for measurement of total inorganic arsenic species in rice flour. As(III) and As(V) eluted at the same retention time and completely separated from organoarsenic species by an isocratic elution program on a reversed phase column. Therefore, neither ambiguous oxidation of arsenite to arsenate nor the integration of two peaks were necessary to determine directly the target analyte inorganic arsenic. Rapid injection allowed measuring 3 replicates within 6min and this combined with a quantitative extraction of all arsenic species from rice flour by a 15min HNO3-H2O2extraction makes this the fastest laboratory based method for inorganic arsenic in rice flour.
authors.affiliation: National Metrology Institute of Japan (NMIJ), National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1 Umezono, Tsukuba, Ibaraki 305-8563, Japan. Electronic address: tomohiro-narukawa@aist.go.jp.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Narukawa
authors.affiliation: Department of Environmental and Applied Chemistry, School of Science and Technology, Kwansei Gakuin University, 2-1 Gakuen, Sanda, Hyogo, 669-1337, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Chiba
authors.affiliation: Environmental Analytical Chemistry TESLA- Trace Element Speciation Laboratory, University of Aberdeen, Meston Building Rm G26, Aberdeen AB24 3UE, Scotland UK.
authors.forename: Savarin
authors.initials: S
authors.lastname: Sinaviwat
authors.affiliation: Environmental Analytical Chemistry TESLA- Trace Element Speciation Laboratory, University of Aberdeen, Meston Building Rm G26, Aberdeen AB24 3UE, Scotland UK.
authors.forename: Jörg
authors.initials: J
authors.lastname: Feldmann
mesh_terms: D001149:Arsenates / Q000032:analysis / Q000302:isolation & purification; D001151:Arsenic / Q000032:analysis* / Q000302:isolation & purification; D018053:Arsenites / Q000032:analysis / Q000302:isolation & purification; D002851:Chromatography, High Pressure Liquid; D056148:Chromatography, Reverse-Phase; D006861:Hydrogen Peroxide / Q000737:chemistry; D013058:Mass Spectrometry; D017942:Nitric Acid / Q000737:chemistry; D012275:Oryza / Q000737:chemistry*
chemical_list: D001149:Arsenates; D018053:Arsenites; D017942:Nitric Acid; D006861:Hydrogen Peroxide; C015001:arsenite; D001151:Arsenic; C025657:arsenic acid
keywords: Arsenic speciation; Extraction; HPLC-ICP-MS; Inorganic arsenic determination; Rice flour; Risk assessment