title: Bioresorbable stents: Current and upcoming bioresorbable technologies.
abstract: Bioresorbable scaffolds (BRS) represent a novel horizon in interventional cardiology for the treatment of coronary artery disease. The technology was introduced to overcome limitations of current metallic drug-eluting stents such as late in-stent restenosis and permanently caging the vessel. The concept of the BRS is to provide temporal support to the vessel during healing before being degraded and resorbed by the body, promoting restoration of the vessel vasomotion. Currently, there are several BRS that are under development or already commercially available. Although several reviews have elegantly covered progress of current clinical programs and newer scaffold technologies, little is available currently to describe the mechanistic differences between biomaterials used in current and newer bioresorbable technologies. This aim of this review is to discuss the status of the different BRS technologies and materials currently under investigation, explore the newer strategies being adopted to improve material mechanical properties and optimize BRS degradation and summarize the performance of BRS in the clinical setting so far.
authors.affiliation: National Heart Centre Singapore, 5 Hospital Drive, 169609, Singapore.
authors.forename: Hui Ying
authors.initials: HY
authors.lastname: Ang
authors.affiliation: National Heart Centre Singapore, 5 Hospital Drive, 169609, Singapore.
authors.forename: Heerajnarain
authors.initials: H
authors.lastname: Bulluck
authors.affiliation: National Heart Centre Singapore, 5 Hospital Drive, 169609, Singapore.
authors.forename: Philip
authors.initials: P
authors.lastname: Wong
authors.affiliation: School of Materials Science and Engineering, Nanyang Technological University, Nanyang Avenue, 639798, Singapore.
authors.forename: Subbu S
authors.initials: SS
authors.lastname: Venkatraman
authors.affiliation: School of Materials Science and Engineering, Nanyang Technological University, Nanyang Avenue, 639798, Singapore. Electronic address: yingyinghuang@ntu.edu.sg.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Huang
authors.affiliation: National Heart Centre Singapore, 5 Hospital Drive, 169609, Singapore; DUKE-NUS Medical School, 8 College Road, 169857, Singapore. Electronic address: nicolas.foin@gmail.com.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Foin
mesh_terms: D020341:Absorbable Implants; D020811:Biomedical Technology / Q000592:standards / Q000639:trends*; D003324:Coronary Artery Disease / Q000628:therapy*; D004869:Equipment Safety; D005260:Female; D005544:Forecasting; D006801:Humans; D008297:Male; D011108:Polymers; D011474:Prosthesis Design; D015607:Stents
chemical_list: D011108:Polymers
keywords: Bioresorbable stents; Coronary artery disease; Coronary stent