title: A novel ratiometric fluorescent probe based on 1, 8-naphthalimide for the detection of Ho3+and its bioimaging.
abstract: A ratiometric fluorescent probe for the detection of Ho3+in DMSO-aqueous medium was designed and synthesized based on 1, 8-naphthalimide. The probe displayed response to Ho3+with a fluorescence decrease at 512nm and enhancement at 480nm, accompanying with a distinct fluorescence change from bright yellow-green to cyan. Besides, the probe exhibited a lower detection limit (6×10-8M) and could be used in intracellular fluorescence imaging. To the best of the knowledge, it was the first ratiometric fluorescent probe for Ho3+detection. This probe was expected to be a useful tool for further elucidating the roles of Ho3+in materials, biology and environment.
authors.affiliation: Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Key Laboratory of Materials for Energy Conversion and Storage of Shanxi Province, Institute of Molecular Science, Shanxi University, Taiyuan 030006, China.
authors.forename: Huifang
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Research Institute of Applied Chemistry, Shanxi University, Taiyuan 030006, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Liu
authors.affiliation: Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Key Laboratory of Materials for Energy Conversion and Storage of Shanxi Province, Institute of Molecular Science, Shanxi University, Taiyuan 030006, China. Electronic address: yincx@sxu.edu.cn.
authors.forename: Caixia
authors.initials: C
authors.lastname: Yin
authors.affiliation: Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Key Laboratory of Materials for Energy Conversion and Storage of Shanxi Province, Institute of Molecular Science, Shanxi University, Taiyuan 030006, China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Wen
authors.affiliation: Research Institute of Applied Chemistry, Shanxi University, Taiyuan 030006, China.
authors.forename: Jianbin
authors.initials: J
authors.lastname: Chao
authors.affiliation: Research Institute of Applied Chemistry, Shanxi University, Taiyuan 030006, China.
authors.forename: Yongbin
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Research Institute of Applied Chemistry, Shanxi University, Taiyuan 030006, China. Electronic address: huofj@sxu.edu.cn.
authors.forename: Fangjun
authors.initials: F
authors.lastname: Huo
mesh_terms: D000072283:A549 Cells; D002470:Cell Survival; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D006695:Holmium / Q000032:analysis*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D021621:Imaging, Three-Dimensional; D007700:Kinetics; D057230:Limit of Detection; D053644:Naphthalimides / Q000737:chemistry*; D055620:Optical Phenomena; D013050:Spectrometry, Fluorescence; D013997:Time Factors
chemical_list: D005456:Fluorescent Dyes; D053644:Naphthalimides; D006695:Holmium
keywords: Bioimaging; Fluorescent probe; Ho(3+); Ratiometric