title: Discovery of natural mouse serum derived HIV-1 entry inhibitor(s).
abstract: Among rationally designed human immunodeficiency virus 1 (HIV-1) inhibitors, diverse natural factors have showed as potent anti-HIV activity in human blood. We have discovered that the boiled supernatant of healthy mouse serum could suppress HIV-1 entry, and exhibited reduced inhibitory activity after trypsin digestion. Further analysis demonstrated that only the fraction containing 10-25 K proteins could inhibit HIV-1 mediated cell-cell fusion. These results suggest that the 10-25 K protein(s) is novel natural HIV-1 entry inhibitor(s). Our findings provide important information about novel natural HIV entry inhibitors in mouse serum.
authors.forename: M
authors.initials: M
authors.lastname: Wei
authors.forename: Y
authors.initials: Y
authors.lastname: Chen
authors.forename: J
authors.initials: J
authors.lastname: Xi
authors.forename: S
authors.initials: S
authors.lastname: Ru
authors.forename: M
authors.initials: M
authors.lastname: Ji
authors.forename: D
authors.initials: D
authors.lastname: Zhang
authors.forename: Q
authors.initials: Q
authors.lastname: Fang
authors.forename: B
authors.initials: B
authors.lastname: Tang
mesh_terms: D000818:Animals; D019380:Anti-HIV Agents / Q000494:pharmacology*; D023581:HIV Fusion Inhibitors / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D051379:Mice / Q000097:blood*; D008810:Mice, Inbred C57BL; D044967:Serum / Q000737:chemistry*; D053586:Virus Internalization / Q000187:drug effects*
chemical_list: D019380:Anti-HIV Agents; D023581:HIV Fusion Inhibitors
keywords: HIV-1; HIV-1 entry; natural inhibitor; mouse serum.