title: Complex Trait Analyses of the Collaborative Cross: Tools and Databases.
abstract: The Collaborative cross (CC) is a powerful mouse resource for investigating complex genetic traits. Here we discuss various tools and techniques for gene mapping and identification using the CC. The data analyses procedures are illustrated with examples.
authors.affiliation: Centre for Diabetes Research, Harry Perkins Institute of Medical Research, The University of Western Australia, 6 Verdun Street, Nedlands, WA, 6009, Australia.
authors.forename: Ramesh
authors.initials: R
authors.lastname: Ram
authors.affiliation: Centre for Diabetes Research, Harry Perkins Institute of Medical Research, The University of Western Australia, 6 Verdun Street, Nedlands, WA, 6009, Australia. grant.morahan@uwa.edu.au.
authors.forename: Grant
authors.initials: G
authors.lastname: Morahan
mesh_terms: D000818:Animals; D002874:Chromosome Mapping / Q000379:methods; D019295:Computational Biology / Q000379:methods; D003433:Crosses, Genetic; D057225:Data Mining; D030561:Databases, Nucleic Acid; D005828:Genetics, Population / Q000379:methods; D016678:Genome; D055106:Genome-Wide Association Study; D023281:Genomics / Q000379:methods; D005838:Genotype; D006239:Haplotypes; D051379:Mice; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci; D019655:Quantitative Trait, Heritable; D012984:Software; D014584:User-Computer Interface
keywords: Analysis tools in systems genetics; Collaborative Cross; Haplotype analysis; Imputation; Mixed model; Quantitative trait loci (QTL) mapping methods; Whole-genome association