title: Association between exposure to ambient particulate matter and chronic obstructive pulmonary disease: results from a cross-sectional study in China.
abstract: The association between exposure to ambient particles with a median aerodynamic diameter less than 10/2.5 µm (particulate matter, PM10/2.5) and COPD remains unclear. Our study objective was to examine the association between ambient PM10/2.5concentrations and lung functions in adults.
  
  
  
  A cross-sectional study was conducted in southern China. Seven clusters were randomly selected from four cities across Guangdong province. Residents aged ≥20 years in the participating clusters were randomly recruited; all eligible participants were examined with a standardised questionnaire and spirometry. COPD was defined as a post-bronchodilator FEV1/FVC less than 70%. Atmosphere PM sampling was conducted across the clusters along with our survey.
  
  
  
  Of the subjects initially recruited, 84.4% (n=5993) were included for analysis. COPD prevalence and atmosphere PM concentration varied significantly among the seven clusters. COPD prevalence was significantly associated with elevated PM concentration levels: adjusted OR 2.416 (95% CI 1.417 to 4.118) for >35 and ≤75 µg/m3and 2.530 (1.280 to 5.001) for >75 µg/m3compared with the level of ≤35 µg/m3for PM2.5; adjusted OR 2.442 (95% CI 1.449 to 4.117) for >50 and ≤150 µg/m3compared with the level of ≤50 µg/m3for PM1. A 10 µg/m3increase in PM2.5concentrations was associated with a 26 mL (95% CI -43 to -9) decrease in FEV1, a 28 mL (-49 to -8) decrease in FVC and a 0.09% decrease (-0.170 to -0.010) in FEV1/FVC ratio. The associations of COPD with PM10were consistent with PM2.5but slightly weaker.
  
  
  
  Exposure to higher PM concentrations was strongly associated with increased COPD prevalence and declined respiratory function.
  
  
  
  ChiCTR-OO-14004264; Post-results.
authors.affiliation: The State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
authors.forename: Sha
authors.initials: S
authors.lastname: Liu
authors.affiliation: The State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
authors.forename: Yumin
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Institute of Earth Environment, Chinese Academy of Sciences, Xi'an, China.
authors.forename: Suixin
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of Pathogenic Biology, Guangzhou Medical University, Guangzhou, China.
authors.forename: Xinyu
authors.initials: X
authors.lastname: Chen
authors.affiliation: Guangzhou Chest Hospital, Guangzhou, Guangdong, China.
authors.forename: Weifeng
authors.initials: W
authors.lastname: Zou
authors.affiliation: The State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
authors.forename: Dongxing
authors.initials: D
authors.lastname: Zhao
authors.affiliation: The State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
authors.forename: Xiaochen
authors.initials: X
authors.lastname: Li
authors.affiliation: The State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
authors.forename: Jinding
authors.initials: J
authors.lastname: Pu
authors.affiliation: The State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
authors.forename: Lingmei
authors.initials: L
authors.lastname: Huang
authors.affiliation: The State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
authors.forename: Jinlong
authors.initials: J
authors.lastname: Chen
authors.affiliation: The Research Center of Experimental Medicine, Guangzhou Medical University, Guangzhou, Guangdong, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Li
authors.affiliation: The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.|School of Epidemiology, Public Health and Preventive Medicine, University of Ottawa, Ottawa ON, Canada.
authors.forename: Shiliang
authors.initials: S
authors.lastname: Liu
authors.affiliation: The State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
authors.forename: Pixin
authors.initials: P
authors.lastname: Ran
mesh_terms: D000328:Adult; D000393:Air Pollutants / Q000009:adverse effects* / Q000032:analysis; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D004781:Environmental Exposure / Q000009:adverse effects / Q000032:analysis; D004784:Environmental Monitoring / Q000379:methods; D005260:Female; D005541:Forced Expiratory Volume / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D052638:Particulate Matter / Q000009:adverse effects* / Q000032:analysis; D015995:Prevalence; D029424:Pulmonary Disease, Chronic Obstructive / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D012307:Risk Factors; D013147:Spirometry / Q000379:methods; D011795:Surveys and Questionnaires; D014797:Vital Capacity / Q000502:physiology
chemical_list: D000393:Air Pollutants; D052638:Particulate Matter
keywords: COPD epidemiology