title: Pediatric Chondromyxoid Fibroma-Like Osteosarcoma.
abstract: Chondromyxoid fibroma-like osteosarcoma (CMF-OS) is a low-grade osteosarcoma, often misdiagnosed on initial biopsy as a benign lesion, with five cases previously described. We report a 13-year-old male with an intramedullary lytic CMF-OS of the right tibial proximal metaphysis with cortical destruction and soft tissue extension. Diagnosis was based on malignant new bone formation, increased mitotic figures, lamellar bone permeation with bony destruction, and correlation with imaging studies. There were no metastasis at presentation and the tumor showed good response to standard chemotherapy with >95% necrosis.
authors.affiliation: a Department of Pathology , Children's Hospital New Orleans , New Orleans , LA , USA.
authors.forename: Matthew
authors.initials: M
authors.lastname: Stark
authors.affiliation: b Tulane University Health Sciences Center , New Orleans , LA , USA.
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Heinrich
authors.affiliation: c Department of Orthopedic Surgery , LSUHSC , New Orleans , LA , USA.
authors.forename: Raju
authors.initials: R
authors.lastname: Sivashanmugam
authors.affiliation: d Department of Radiology , LSUHSC , New Orleans , LA , USA.
authors.forename: Dane
authors.initials: D
authors.lastname: Mackey
authors.affiliation: e Department of Radiology , Children's Hospital New Orleans , New Orleans , LA , USA.
authors.forename: Ewa
authors.initials: E
authors.lastname: Wasilewska
authors.affiliation: a Department of Pathology , Children's Hospital New Orleans , New Orleans , LA , USA.|f Department of Pathology , LSUHSC , New Orleans , LA , USA.
authors.forename: Randall
authors.initials: R
authors.lastname: Craver
mesh_terms: D000293:Adolescent; D001706:Biopsy / Q000379:methods; D001859:Bone Neoplasms / Q000175:diagnosis / Q000473:pathology*; D003937:Diagnosis, Differential; D005350:Fibroma / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D008297:Male; D060787:Neoplasm Grading / Q000379:methods; D009362:Neoplasm Metastasis / Q000473:pathology; D012516:Osteosarcoma / Q000175:diagnosis / Q000473:pathology*
keywords: CDK4; MDM2; Osteosarcoma; chondromyxoid fibroma-like; pediatrics