title: One-Pot Preparation of Dimethyl Isosorbide from d-Sorbitol via Dimethyl Carbonate Chemistry.
abstract: Direct synthesis of dimethyl isosorbide (DMI) from d-sorbitol via dimethyl carbonate (DMC) chemistry is herein first reported. High yield of DMI was achieved using the nitrogen superbase 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) as catalyst and performing the reaction in a stainless steel autoclave by increasing the temperature from 90 to 200 °C. In this procedure, DMC features its full capacity acting in the different steps of the process as carboxymethylating, leaving-group (cyclization), and methylating agent; DMC is also employed as the reaction media.
authors.affiliation: Department of Environmental Science, informatics and Statistics, Ca' Foscari University, Campus Universitario, Via Torino 155, 30170, Venezia mestre, Italy.
authors.forename: F
authors.identifier: http://orcid.org/0000-0002-9946-4803
authors.initials: F
authors.lastname: Aricò
authors.affiliation: Department of Environmental Science, informatics and Statistics, Ca' Foscari University, Campus Universitario, Via Torino 155, 30170, Venezia mestre, Italy.
authors.forename: A S
authors.initials: AS
authors.lastname: Aldoshin
authors.affiliation: Department of Environmental Science, informatics and Statistics, Ca' Foscari University, Campus Universitario, Via Torino 155, 30170, Venezia mestre, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Tundo
mesh_terms: D002384:Catalysis; D005561:Formates / Q000737:chemistry*; D007547:Isosorbide / Q000031:analogs & derivatives* / Q000737:chemistry; D013012:Sorbitol / Q000737:chemistry*
chemical_list: D005561:Formates; D013012:Sorbitol; C023025:methyl carbonate; C040079:2,5-dimethylisosorbide; D007547:Isosorbide
keywords: cyclic sugar; cyclization; dimethyl carbonate; isosorbide; methylation