title: Classification Systems of Secondary Active Transporters.
abstract: Membrane-bound solute carrier (SLC) transporter proteins are vital to the human body, as they sustain homeostasis by moving soluble molecule as nutrients, drugs, and waste across lipid membranes. Of the 430 identified secondary active transporters in humans, 30% are still orphans, and systematic research has been requested to elaborate on their possible involvement in diseases and their potential as drug targets. To enable this, the various classification systems in use must be understood and used correctly. In this review, we describe how various classification systems for human SLCs are constructed, and how they overlap and differ. To facilitate communication between researchers and to avoid ambiguities, everyone must clearly state which classification system they are referring to when writing scientific articles.
authors.affiliation: Department of Pharmaceutical Bioscience, Molecular Neuropharmacology, Uppsala University, Uppsala SE 7512, Sweden.
authors.forename: Emelie
authors.initials: E
authors.lastname: Perland
authors.affiliation: Department of Pharmaceutical Bioscience, Molecular Neuropharmacology, Uppsala University, Uppsala SE 7512, Sweden. Electronic address: Robert.Fredriksson@farmbio.uu.se.
authors.forename: Robert
authors.initials: R
authors.lastname: Fredriksson
mesh_terms: D001693:Biological Transport, Active; D006801:Humans; D008563:Membrane Lipids / Q000378:metabolism; D000070590:Solute Carrier Proteins / Q000737:chemistry / Q000145:classification* / Q000378:metabolism
chemical_list: D008563:Membrane Lipids; D000070590:Solute Carrier Proteins
keywords: amino acid/polyamine/organocation; classification; major facilitator superfamily; secondary active transporters; solute carrier