title: Exercise Training Prevents Cardiovascular Derangements Induced by Fructose Overload in Developing Rats.
abstract: The risks of chronic diseases associated with the increasing consumption of fructose-laden foods are amplified by the lack of regular physical activity and have become a serious public health issue worldwide. Moreover, childhood eating habits are strongly related to metabolic syndrome in adults. Thus, we aimed to investigate the preventive role of exercise training undertaken concurrently with a high fructose diet on cardiac function, hemodynamics, cardiovascular autonomic modulation and oxidative stress in male rats after weaning. Male Wistar rats were divided into 4 groups (n = 8/group): Sedentary control (SC), Trained control (TC), Sedentary Fructose (SF) and Trained Fructose (TF). Training was performed on a treadmill (8 weeks, 40-60% of maximum exercise test). Evaluations of cardiac function, hemodynamics, cardiovascular autonomic modulation and oxidative stress in plasma and in left ventricle (LV) were performed. Chronic fructose overload induced glucose intolerance and an increase in white adipose tissue (WAT) weight, in myocardial performance index (MPI) (SF:0.42±0.04 vs. SC:0.24±0.05) and in arterial pressure (SF:122±3 vs. SC:113±1 mmHg) associated with increased cardiac and vascular sympathetic modulation. Fructose also induced unfavorable changes in oxidative stress profile (plasmatic protein oxidation- SF:3.30±0.09 vs. SC:1.45±0.08 nmol/mg prot; and LV total antioxidant capacity (TRAP)- SF: 2.5±0.5 vs. SC:12.7±1.7 uM trolox). The TF group showed reduced WAT, glucose intolerance, MPI (0.35±0.04), arterial pressure (118±2mmHg), sympathetic modulation, plasmatic protein oxidation and increased TRAP when compared to SF group. Therefore, our findings indicate that cardiometabolic dysfunctions induced by fructose overload early in life may be prevented by moderate aerobic exercise training.
authors.affiliation: Laboratory of Metabolic Cardiovascular and Renal Physiopharmacology, Universidade Presbiteriana Mackenzie, Sao Paulo, Brazil.|Laboratory Experimental Hypertension, Heart Institute (INCOR), School of Medicine, Sao Paulo University (FMUSP), Sao Paulo, Brazil.
authors.forename: Daniela
authors.initials: D
authors.lastname: Farah
authors.affiliation: Laboratory of Metabolic Cardiovascular and Renal Physiopharmacology, Universidade Presbiteriana Mackenzie, Sao Paulo, Brazil.
authors.forename: Jonas
authors.initials: J
authors.lastname: Nunes
authors.affiliation: Laboratory Experimental Hypertension, Heart Institute (INCOR), School of Medicine, Sao Paulo University (FMUSP), Sao Paulo, Brazil.|Laboratory of Translational Physiology, Universidade Nove de Julho, Sao Paulo, Brazil.
authors.forename: Michelle
authors.initials: M
authors.lastname: Sartori
authors.affiliation: Laboratory of Translational Physiology, Universidade Nove de Julho, Sao Paulo, Brazil.
authors.forename: Danielle da Silva
authors.initials: DD
authors.lastname: Dias
authors.affiliation: Laboratory Experimental Hypertension, Heart Institute (INCOR), School of Medicine, Sao Paulo University (FMUSP), Sao Paulo, Brazil.
authors.forename: Raquel
authors.initials: R
authors.lastname: Sirvente
authors.affiliation: Laboratory Experimental Hypertension, Heart Institute (INCOR), School of Medicine, Sao Paulo University (FMUSP), Sao Paulo, Brazil.
authors.forename: Maikon B
authors.initials: MB
authors.lastname: Silva
authors.affiliation: Laboratory of Metabolic Cardiovascular and Renal Physiopharmacology, Universidade Presbiteriana Mackenzie, Sao Paulo, Brazil.
authors.forename: Patrícia
authors.initials: P
authors.lastname: Fiorino
authors.affiliation: Institute Neuro Immune Medicine, Nova Southeastern University, Fort Lauderdale, United States of America.
authors.forename: Mariana
authors.initials: M
authors.lastname: Morris
authors.affiliation: Department of General and Inorganic Chemistry, University of Buenos Aires, Buenos Aires, Argentina.
authors.forename: Susana
authors.initials: S
authors.lastname: Llesuy
authors.affiliation: Laboratory of Metabolic Cardiovascular and Renal Physiopharmacology, Universidade Presbiteriana Mackenzie, Sao Paulo, Brazil.
authors.forename: Vera
authors.initials: V
authors.lastname: Farah
authors.affiliation: Laboratory Experimental Hypertension, Heart Institute (INCOR), School of Medicine, Sao Paulo University (FMUSP), Sao Paulo, Brazil.
authors.forename: Maria-Cláudia
authors.initials: MC
authors.lastname: Irigoyen
authors.affiliation: Laboratory of Translational Physiology, Universidade Nove de Julho, Sao Paulo, Brazil.
authors.forename: Kátia
authors.initials: K
authors.lastname: De Angelis
mesh_terms: D000818:Animals; D001794:Blood Pressure; D002319:Cardiovascular System / Q000503:physiopathology*; D005632:Fructose / Q000008:administration & dosage*; D006339:Heart Rate; D008297:Male; D018384:Oxidative Stress; D010805:Physical Conditioning, Animal; D051381:Rats; D017208:Rats, Wistar
chemical_list: D005632:Fructose