title: Possible Role of Sildenafil Citrate in the Recurrence of Neovascularization in Laser-regressed Aggressive Posterior ROP.
abstract: BACKGROUND
  Systemic diseases and their treatment influence aggressive posterior retinopathy of prematurity.
  
  
  METHODS
  A premature infant with aggressive posterior retinopathy of prematurity underwent laser treatment with a favourable outcome. She was started on oral sidenafil citrate for pulmonary hypertension. Ten days later she developed neovascularization within the lasered retina.
  
  
  RESULTS
  Considering the possible role of sildenafil in this unusual development, the drug was withdrawn resulting in regression of the neovascularization.
  
  
  CONCLUSIONS
  The clinician should be aware of this retinal adverse effect of sildanefil in neonates with aggressive posterior retinopathy of prematurity.
authors.affiliation: Departments of Pediatric Retina, Narayana Nethralaya Institute ; and #Neonatology, Columbia Asia Referral Hospital, Bangalore, India. Correspondence to: Dr Anand Vinekar, Department of Pediatric Retina, Narayana Nethralaya Eye Institute, 121C, 1st R Block, Rajajinagar, Bangalore 560010, India. anandvinekar@yahoo.com.
authors.forename: Chaitra
authors.initials: C
authors.lastname: Jayadev
authors.forename: Phanibhushan
authors.initials: P
authors.lastname: Ramasastry
authors.forename: Alia
authors.initials: A
authors.lastname: Gul
authors.forename: Anand
authors.initials: A
authors.lastname: Vinekar
mesh_terms: D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008028:Light Coagulation; D028022:Low-Level Light Therapy; D012178:Retinopathy of Prematurity / Q000628:therapy*; D000068677:Sildenafil Citrate / Q000008:administration & dosage / Q000627:therapeutic use; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D014665:Vasodilator Agents; D000068677:Sildenafil Citrate