title: Is the Monocyte/HDL Ratio a Prognostic Marker of Idiopathic Sudden Hearing Loss?
abstract: OBJECTIVE
  In this study, our aim was to investigate whether Monocyte/HDL ratio is a marker of the prognosis of the idiopathic sudden hearing loss (ISHL).
  
  
  METHODS
  Retrospective, case-control clinical trial.
  
  
  METHODS
  45 patients, who were diagnosed with idiopathic sudden hearing loss and were treated with the same therapy regime and 47 healthy volunteers, who applied to the hospital for routine controls and had audiological and laboratory examination between March 2014 and December 2015, were included in the study. Monocyte/HDL ratios of the patients in the study and control groups were calculated from the results of the blood counts and biochemical analysis. Additionally, the study group was divided into two sub-groups regarding their responses (responders and non-responders) to the treatment determined by the audiological examination, which was carried out after 3 months according to the Siegel criteria. The Monocyte/HDL ratios between the groups were statistically evaluated.
  
  
  RESULTS
  There was no statistically significant difference between the MHRs of the study and control groups (p=0.574). However, the MHR was significantly higher in the non-responders? group compared with the responders? group, although they were treated with the same therapy regimen (p=0.005).
  
  
  CONCLUSIONS
  There was no difference in MHRs between study and control groups. However, as MHR was higher in the patients with good prognosis compared with the patients with bad prognosis, we believe that regarding the ISHL, MHR is not a predictive value but might have prognostic marker.
authors.affiliation: Bakırköy Dr.Sadi Konuk Training and Research Hospital, Department of Otorhinolaryngology - Head and Neck Surgery, Istanbul, Turkey.
authors.forename: Hasan Emre
authors.initials: HE
authors.lastname: Koçak
authors.affiliation: Bakırköy Dr.Sadi Konuk Training and Research Hospital, Department of Otorhinolaryngology - Head and Neck Surgery, Istanbul, Turkey.
authors.forename: Harun
authors.initials: H
authors.lastname: Acipayam
authors.affiliation: Bakırköy Dr.Sadi Konuk Training and Research Hospital, Department of Otorhinolaryngology - Head and Neck Surgery, Istanbul, Turkey.
authors.forename: Mustafa Suphi
authors.initials: MS
authors.lastname: Elbistanlı
authors.affiliation: Bakırköy Dr. Sadi Konuk Education and Research Hospital, Department of Otolaryngology.
authors.forename: Ayşe Pelin
authors.initials: AP
authors.lastname: Yiğider
authors.affiliation: Bakırköy Dr.Sadi Konuk Training and Research Hospital, Department of Otorhinolaryngology - Head and Neck Surgery, Istanbul, Turkey.
authors.forename: Wesam
authors.initials: W
authors.lastname: Alakhras
authors.affiliation: Bakırköy Dr.Sadi Konuk Training and Research Hospital, Department of Otorhinolaryngology - Head and Neck Surgery, Istanbul, Turkey.
authors.forename: Mehmet Nurettin
authors.initials: MN
authors.lastname: Kıral
authors.affiliation: Bakırköy Dr.Sadi Konuk Training and Research Hospital, Department of Otorhinolaryngology - Head and Neck Surgery, Istanbul, Turkey.
authors.forename: Fatma Tülin
authors.initials: FT
authors.lastname: Kayhan
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood*; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000097:blood* / Q000503:physiopathology*; D003639:Hearing Loss, Sudden / Q000097:blood* / Q000175:diagnosis*; D006801:Humans; D008297:Male; D009000:Monocytes / Q000737:chemistry* / Q000473:pathology; D012189:Retrospective Studies
chemical_list: D015415:Biomarkers; D008076:Cholesterol, HDL
keywords: HDL; Monocyte; Ratio; hearing loss