title: Effects of alpha-lipoic acid supplementation on growth performance, antioxidant capacity and biochemical parameters for ammonia-exposed broilers.
abstract: In order to estimate the effect of alpha-lipoic acid (LA) supplementation on relieving ammonia stress of broilers, 180 22-day-old male broilers were assigned to three groups, six replicates in each group and 10 birds per replicate. The three groups were: (1) a control group without ammonia stress; (2) exposure to 70 ppm atmospheric ammonia (AM); (3) exposure to 70 ppm atmospheric ammonia and administration of 300 mg/kg LA (AM + LA). The experimental period was 3 weeks. Results showed that average daily weight gain was increased and feed conversion ratio was decreased in the AM + LA group, compared with the AM group (P < 0.05). Total superoxide dismutase and glutathione peroxidase activities in serum, and glutathione content in liver were higher in the AM + LA group than that in the AM group (P < 0.05); however, serum malondialdehyde content was decreased by LA addition (P < 0.05). Additionally, serum glutamic-pyruvic transaminase, creatine kinase and lactate dehydrogenase activities were reduced and albumin level was increased by LA addition (P < 0.05). In conclusion, LA addition could relieve ammonia stress to restore broiler production performance to normal levels.
authors.affiliation: Institute of Animal Husbandry and Veterinary Science, Henan Academy of Agricultural Sciences, Zhengzhou, China.|College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.
authors.forename: Min
authors.initials: M
authors.lastname: Lu
authors.affiliation: Institute of Animal Husbandry and Veterinary Science, Henan Academy of Agricultural Sciences, Zhengzhou, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Bai
authors.affiliation: Institute of Animal Husbandry and Veterinary Science, Henan Academy of Agricultural Sciences, Zhengzhou, China.
authors.forename: Fengxian
authors.initials: F
authors.lastname: Wei
authors.affiliation: Institute of Animal Husbandry and Veterinary Science, Henan Academy of Agricultural Sciences, Zhengzhou, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Xu
authors.affiliation: Institute of Animal Husbandry and Veterinary Science, Henan Academy of Agricultural Sciences, Zhengzhou, China.
authors.forename: Quanyou
authors.initials: Q
authors.lastname: Sun
authors.affiliation: Institute of Animal Husbandry and Veterinary Science, Henan Academy of Agricultural Sciences, Zhengzhou, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.affiliation: Institute of Animal Husbandry and Veterinary Science, Henan Academy of Agricultural Sciences, Zhengzhou, China.
authors.forename: Gaili
authors.initials: G
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, The Chinese Academy of Agricultural Sciences, Beijing, China.
authors.forename: Xiangfang
authors.initials: X
authors.lastname: Tang
authors.affiliation: State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, The Chinese Academy of Agricultural Sciences, Beijing, China.
authors.forename: Hongfu
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Institute of Animal Husbandry and Veterinary Science, Henan Academy of Agricultural Sciences, Zhengzhou, China.
authors.forename: Qingqiang
authors.initials: Q
authors.lastname: Yin
authors.affiliation: College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.
authors.forename: Shaoyu
authors.initials: S
authors.lastname: Li
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000641:Ammonia / Q000009:adverse effects*; D000818:Animals; D002645:Chickens / Q000254:growth & development* / Q000378:metabolism*; D003402:Creatine Kinase / Q000097:blood; D004032:Diet / Q000662:veterinary*; D019587:Dietary Supplements; D004781:Environmental Exposure / Q000009:adverse effects*; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000097:blood*; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008099:Liver / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D012709:Serum Albumin / Q000378:metabolism; D013312:Stress, Physiological / Q000187:drug effects*; D013482:Superoxide Dismutase / Q000097:blood*; D008063:Thioctic Acid / Q000008:administration & dosage* / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D012709:Serum Albumin; D008315:Malondialdehyde; D008063:Thioctic Acid; D000641:Ammonia; D007770:L-Lactate Dehydrogenase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D000410:Alanine Transaminase; D003402:Creatine Kinase; D005978:Glutathione
keywords: alpha-lipoic acid; ammonia stress; antioxidant capability; broiler; growth performance