title: Six New Triterpene Derivatives from Aralia chinensis Var. dasyphylloides.
abstract: Aralia chinensisvar.dasyphylloidesis widely distributed in China and used as a traditional herbal medicine for the treatment of digestive and immune system diseases. The present study aimed to search for novel oleanolic-type triterpenoids in low-polarity fractions. Six new triterpene derivatives (1-6), together with two known compounds were isolated from the barks ofA. chinensisvar.dasyphylloides. Their structures were elucidated by 1D- and 2D-NMR spectroscopic analysis and chemical methods. They were identified as 3-oxo-oleana-11,13(18)-dien-28,30-dioic acid (1), 30-hydroxy-3-oxo-oleana-11,13(18)-dien-28-oic acid (2), 3β-hydroxy-oleana-11,13(18)-dien-28-oic acid-28-O-β-d-glucopyranoside (3), 3β,30-dihydroxy-oleana-11,13(18)-dien-28-oic acid-28-O-β-d-glucopyranoside (4), 3β-hydroxy-oleana-11,13(18)-dien-28-oic acid-3-O-β-d-xylopyranosyl-(1 → 2)-β-d-glucopyranoside (5), 3β,29-dihydroxy-oleana-9(11),12-dien-28-oic acid-28-O-β-d-glucopyranoside (6), namely, araliachinolic acids I and II and araliachinosides I-IV. The cytotoxicity of the isolated compounds was tested against HepG2, A549, SGC7901, and MCF7 cell lines, but no apparent activity was observed at a concentration of 50 μM.
authors.affiliation: Laboratory for Natural Product Chemistry, College of Pharmacy, South-Central University for Nationalities, Wuhan 430074, China. gaoruixi@gmail.com.
authors.forename: Rui-Xi
authors.initials: RX
authors.lastname: Gao
authors.affiliation: College of Pharmacy, South-Central University for Nationalities, Wuhan 430074, China. sippr1976@163.com.
authors.forename: Maochuan
authors.initials: M
authors.lastname: Liao
authors.affiliation: College of Pharmacy, South-Central University for Nationalities, Wuhan 430074, China. xianju@mail.scuec.edu.cn.
authors.forename: Xianju
authors.initials: X
authors.lastname: Huang
authors.affiliation: College of Chemistry and Material Sciences, South-Central University for Nationalities, Wuhan 430074, China. chenyuwh888@126.com.
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.affiliation: College of Pharmacy, South-Central University for Nationalities, Wuhan 430074, China. yanggz888@126.com.
authors.forename: Guangzhong
authors.initials: G
authors.lastname: Yang
authors.affiliation: College of Pharmacy, South-Central University for Nationalities, Wuhan 430074, China. lijun-pharm@hotmail.com.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D027983:Aralia / Q000737:chemistry*; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D056945:Hep G2 Cells; D006801:Humans; D061986:MCF-7 Cells; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D003603:Cytotoxins; D014315:Triterpenes
keywords: Aralia chinensis var. dasyphylloides; araliachinolic acids I and II; araliachinosides I–IV; triterpene derivatives