title: Effect of dexmedetomidine on postoperative cognitive dysfunction in elderly patients after general anaesthesia: A meta-analysis.
abstract: Objective We undertook a meta-analysis to investigate the effect of dexmedetomidine on postoperative cognitive dysfunction (POCD). Methods We searched PubMed, EMBASE, the Cochrane Library, CNKI and Google Scholar to find randomized controlled trials (RCTs) of the influence of dexmedetomidine on POCD in elderly adults who had undergone general anaesthesia. Two researchers independently screened the literature, extracted data, and evaluated methodologic quality against inclusion and exclusion criteria. We used RevMan 5.2 to undertake our meta-analysis. Results Thirteen RCTs were included. Compared with controls, dexmedetomidine: 1) significantly reduced the incidence of POCD (relative risk = 0.59, 95% confidence interval [CI] 0.45-2.95) and improved Mini-Mental State Examination (MMSE) score (mean difference, MD = 1.74, 95% CI 0.43-3.05) on the first postoperative day; and 2) reduced the incidence of POCD after the first postoperative day (MD = 2.73, 95% CI 1.33-4.12). Conclusion Dexmedetomidine reduces the incidence of POCD and improves postoperative MMSE score.
authors.affiliation: 1 Department of Anesthesiology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, China.|2 Zhaoqing Medical College, Zhaoqing, China.
authors.forename: Chengmao
authors.initials: C
authors.lastname: Zhou
authors.affiliation: 2 Zhaoqing Medical College, Zhaoqing, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: 1 Department of Anesthesiology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Liu
authors.affiliation: 1 Department of Anesthesiology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Ruan
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D018712:Analgesics, Non-Narcotic / Q000627:therapeutic use*; D000768:Anesthesia, General / Q000009:adverse effects*; D060825:Cognitive Dysfunction / Q000503:physiopathology / Q000517:prevention & control*; D020927:Dexmedetomidine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D011183:Postoperative Complications / Q000503:physiopathology / Q000517:prevention & control*; D011184:Postoperative Period; D016032:Randomized Controlled Trials as Topic; D013514:Surgical Procedures, Operative / Q000379:methods*
chemical_list: D018712:Analgesics, Non-Narcotic; D020927:Dexmedetomidine
keywords: POCD; RCT; Response: dexmedetomidine; cognitive function; general anesthesia; meta-analysis