title: Anti-MOG (Myelin Oligodendrocyte Glycoprotein)-Positive Severe Optic Neuritis with Optic Disc Ischaemia and Macular Star.
abstract: A 44-year-old man presented with severe right visual loss. The right fundus examination showed marked optic disc oedema associated with partial macular star. Serological blood tests for infectious agents were all negative. Serum aquaporin-4 antibody was negative but anti-MOG (myelin oligodendrocyte glycoprotein) was positive. Magnetic resonance revealed extensive lesion in right optic nerve. There was no visual improvement after intravenous therapy. Patient had no further attacks after follow-up. Optic disc oedema with macular star is found in several infectious and non-inflammatory disorders, but it has not been reported in optic neuritis (ON) associated with autoantibodies to myelin oligodendrocyte glycoprotein (anti-MOG).
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, University of Sao Paulo , Sao Paulo, Brazil.
authors.forename: Frederico Castelo
authors.initials: FC
authors.lastname: Moura
authors.affiliation: Department of Neurology, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil, ; Department of Multiple Sclerosis Therapeutics, Tohoku University Graduate School of Medicine, Sendai, Japan, and.
authors.forename: Douglas Kazutoshi
authors.initials: DK
authors.lastname: Sato
authors.affiliation: Department of Radiology and Oncology, Faculty of Medicine, University of Sao Paulo , Sao Paulo, Brazil.
authors.forename: Carolina Medeiros
authors.initials: CM
authors.lastname: Rimkus
authors.affiliation: Department of Neurology, Faculty of Medicine, University of Sao Paulo , Sao Paulo, Brazil.
authors.forename: Samira Luisa
authors.initials: SL
authors.lastname: Apóstolos-Pereira
authors.affiliation: Department of Neurology, Faculty of Medicine, University of Sao Paulo , Sao Paulo, Brazil.
authors.forename: Luana Michelli
authors.initials: LM
authors.lastname: de Oliveira
authors.affiliation: Department of Radiology and Oncology, Faculty of Medicine, University of Sao Paulo , Sao Paulo, Brazil.
authors.forename: Claudia Costa
authors.initials: CC
authors.lastname: Leite
authors.affiliation: Department of Multiple Sclerosis Therapeutics, Tohoku University Graduate School of Medicine , Sendai, Japan , and.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Fujihara
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, University of Sao Paulo , Sao Paulo, Brazil.
authors.forename: Mario Luiz Ribeiro
authors.initials: ML
authors.lastname: Monteiro
authors.affiliation: Department of Neurology, Faculty of Medicine, University of Sao Paulo , Sao Paulo, Brazil.
authors.forename: Dagoberto
authors.initials: D
authors.lastname: Callegaro
keywords: Devic’s syndrome; macular star; multiple sclerosis; myelin oligodendrocyte glycoprotein antibody; optic neuritis