title: Toxicity of ar-curcumene and epi-β-bisabolol from Hedychium larsenii (Zingiberaceae) essential oil on malaria, chikungunya and St. Louis encephalitis mosquito vectors.
abstract: Mosquitoes act as vectors of key pathogens and parasites. Plant essential oils have been recognized as important sources of biopesticides, which do not induce resistance and have limited toxic effects on human health and non-target organisms. In this research, we evaluated the larvicidal and oviposition deterrence activity of Hedychium larsenii essential oil (EO) and its major compounds ar-curcumene and epi-β-bisabolol. Both molecules showed high toxicity against early third instars of Anopheles stephensi (LC50=10.45 and 14.68µg/ml), Aedes aegypti (LC50=11.24 and 15.83µg/ml) and Culex quinquefasciatus (LC50=12.24 and 17.27µg/ml). In addition, low doses of ar-curcumene and epi-β-bisabolol were effective as oviposition deterrents against the three tested mosquito species. Notably, the acute toxicity of H. larsenii oil and its major compounds against the mosquito biocontrol agent Poecilia reticulata was low, with LC50higher than 1500ppm. Overall, the results from this study revealed that ar-curcumene and epi-β-bisabolol from the H. larsenii oil can be considered for the development of novel and effective mosquito larvicides.
authors.affiliation: Department of Obstetrics and Gynecology, College of Medicine, King Saud University and King Saud University Medical City, Riyadh, Saudi Arabia.
authors.forename: Mashael Marzouq
authors.initials: MM
authors.lastname: AlShebly
authors.affiliation: Hematology Unit, Department of Pathology, College of Medicine, King Saud University and King Saud University Medical City, Riyadh, Saudi Arabia.
authors.forename: Fatma Saeed
authors.initials: FS
authors.lastname: AlQahtani
authors.affiliation: Unit of Vector Control, Phytochemistry and Nanotechnology, Department of Zoology, Annamalai University, Annamalainagar 608002, Tamil Nadu, India. Electronic address: drgovind1979@gmail.com.
authors.forename: Marimuthu
authors.initials: M
authors.lastname: Govindarajan
authors.affiliation: Department of Botany, Bharathiar University, Coimbatore 641046, Tamil Nadu, India.
authors.forename: Kasi
authors.initials: K
authors.lastname: Gopinath
authors.affiliation: Unit of Vector Control, Phytochemistry and Nanotechnology, Department of Zoology, Annamalai University, Annamalainagar 608002, Tamil Nadu, India.
authors.forename: Periasamy
authors.initials: P
authors.lastname: Vijayan
authors.affiliation: Department of Agriculture, Food and Environment, University of Pisa, via del Borghetto 80, 56124, Pisa, Italy. Electronic address: benelli.giovanni@gmail.com.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Benelli
mesh_terms: D000330:Aedes / Q000254:growth & development / Q000469:parasitology / Q000821:virology; D000818:Animals; D000852:Anopheles / Q000254:growth & development / Q000469:parasitology / Q000821:virology; D003465:Culex / Q000254:growth & development / Q000469:parasitology / Q000821:virology; D004305:Dose-Response Relationship, Drug; D004665:Encephalitis Virus, St. Louis; D007306:Insecticides / Q000737:chemistry*; D007814:Larva; D007928:Lethal Dose 50; D000081222:Monocyclic Sesquiterpenes; D000072138:Mosquito Vectors / Q000254:growth & development* / Q000469:parasitology / Q000821:virology; D009822:Oils, Volatile / Q000494:pharmacology*; D010058:Oviposition; D010936:Plant Extracts / Q000494:pharmacology; D012717:Sesquiterpenes / Q000494:pharmacology*; D030521:Zingiberaceae / Q000737:chemistry*
chemical_list: D007306:Insecticides; D000081222:Monocyclic Sesquiterpenes; D009822:Oils, Volatile; D010936:Plant Extracts; D012717:Sesquiterpenes; C004497:bisabolol; C086829:alpha-curcumene
keywords: Biosafety; Dengue; Filariasis; Non-target organism; Oviposition deterrent; Zika virus