title: Percutaneous trigeminal ganglion radiofrequency thermocoagulation alleviates anxiety and depression disorders in patients with classic trigeminal neuralgia: A cohort study.
abstract: Trigeminal neuralgia (TN) is a neurological condition that presents as excruciating facial pain. Depression and anxiety are commonly associated with TN; however, anxiety and depression disorders in patients with TN and the effects of the various therapeutic strategies for TN on these disorders are not well studied.To evaluate depression and anxiety in patients with trigeminal neuralgia (TN), identify factors that predict their occurrence and study the effect of the percutaneous trigeminal ganglion radiofrequency thermocoagulation (PRT) procedure for alleviating pain on depression and anxiety.Patients with classic TN, who received PRT treatment, were consecutively recruited between October 2014 and October 2015. Severity of pain was determined using the visual analogue scale (VAS) score. Beck Depression Inventory-II (BDI) and Beck anxiety Inventory (BAI) were used to evaluate depression and anxiety disorders pre- and post-PRT. Medical, demographic, and psychosocial backgrounds were also assessed as predictive factors. A BDI score of ≥14 represented depression and BAI score of ≥45 represented anxiety. VAS, BDI, and BAI scores were collected at the time of admission and on the day of discharge.Of the 167 patients who participated in the study, 121 (72.5%) had depression and 34 (20.4%) suffered anxiety. Pre-PRT procedure, female sex, age >50 years, ineffective treatment, and high pain intensity (VAS ≥7) predicted the development of depression and anxiety. Post-PRT procedure, all patients who experienced pain relief also reported amelioration of depression and anxiety.A considerable percentage of patients with TN developed depression and anxiety. Patients who were female, older than 50 years, or suffered from failure treatment and severe pain (VAS>7), were at higher risk of depression and anxiety development. Complete alleviation of pain by using surgical PRT could immediately attenuate depressive and anxiety disorders associated with TN.
authors.affiliation: Department of Pain Management, Xuanwu Hospital, Capital Medical University, Beijing Department of Anesthesiology and Pain Management, Daqing Group Oilfield General Hospital, Heilongjiang, China.
authors.forename: YuanZhang
authors.initials: Y
authors.lastname: Tang
authors.forename: Ling
authors.initials: L
authors.lastname: Ma
authors.forename: Na
authors.initials: N
authors.lastname: Li
authors.forename: Yuna
authors.initials: Y
authors.lastname: Guo
authors.forename: Liqiang
authors.initials: L
authors.lastname: Yang
authors.forename: Baishan
authors.initials: B
authors.lastname: Wu
authors.forename: Jianning
authors.initials: J
authors.lastname: Yue
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
authors.forename: Jingjie
authors.initials: J
authors.lastname: Liu
authors.forename: Jia-Xiang
authors.initials: JX
authors.lastname: Ni
mesh_terms: D000293:Adolescent; D000328:Adult; D001008:Anxiety Disorders / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D015331:Cohort Studies; D003866:Depressive Disorder / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D004564:Electrocoagulation / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D017060:Patient Satisfaction / Q000706:statistics & numerical data; D015995:Prevalence; D012189:Retrospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D012668:Trigeminal Ganglion / Q000601:surgery; D014277:Trigeminal Neuralgia / Q000150:complications / Q000175:diagnosis / Q000601:surgery*; D055815:Young Adult