title: KSHV strategies for host dsDNA sensing machinery.
abstract: The innate immune system utilizes pattern recognition receptors cyclic GMP-AMP synthase (cGAS) to sense cytosolic double-stranded (ds) DNA and initiate type 1 interferon signaling and autophagy pathway, which collaborate to limit pathogen infections as well as alarm the adaptive immune response. The genomes of herpesviruses are large dsDNA, which represent a major class of pathogen signatures recognized by cellular DNA sensor cGAS. However, to successfully establish the persistent infection, herpesviruses have evolved their viral genes to modulate different aspects of host immune signaling. This review summarizes the evasion strategies of host cGAS DNA sensing pathway by Kaposi's Sarcoma-associated Herpesvirus (KSHV) and their contributions to KSHV life cycles.
authors.affiliation: Department of Bone and Joint Surgery, The First Hospital of Jilin University, Changchun, 130021, China.
authors.forename: Hang
authors.initials: H
authors.lastname: Gao
authors.affiliation: Department of Nephrology, The Second Hospital of Jilin University, Changchun, 130041, China.
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Song
authors.affiliation: Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
authors.forename: Chengrong
authors.initials: C
authors.lastname: Liu
authors.affiliation: Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. liangqiming@shsmu.edu.cn.
authors.forename: Qiming
authors.initials: Q
authors.lastname: Liang
mesh_terms: D000818:Animals; D001343:Autophagy / Q000235:genetics / Q000276:immunology; D004247:DNA / Q000235:genetics*; D004279:DNA, Viral / Q000235:genetics*; D019288:Herpesvirus 8, Human / Q000235:genetics* / Q000276:immunology; D054884:Host-Pathogen Interactions; D006801:Humans; D057131:Immune Evasion; D007113:Immunity, Innate; D051192:Receptors, Pattern Recognition; D012514:Sarcoma, Kaposi / Q000235:genetics* / Q000821:virology*; D014764:Viral Proteins / Q000378:metabolism
chemical_list: D004279:DNA, Viral; D051192:Receptors, Pattern Recognition; D014764:Viral Proteins; D004247:DNA
keywords: Kaposi’s sarcoma-associated herpesvirus (KSHV); autophagy; cyclic GMP-AMP synthase (cGAS); evasion strategies; innate immune response; interferon