title: Effect of Unplanned Therapy on the Prognosis of Patients with Extremity Osteosarcoma.
abstract: Unplanned therapy for extremity osteosarcoma can result in erroneous surgical procedures and lack of neoadjuvant chemotherapy before the first operation. Our aim was to compare the prognosis between patients with extremity osteosarcoma who received unplanned therapy and those who received standard treatment. This was a retrospective review of patients with extremity osteosarcoma who received appropriate surgical treatment and neoadjuvant chemotherapy (n = 79) and those who received unplanned therapy (n = 24) between June 2000 and October 2014. Survival rate, local recurrence rate and metastasis rate were compared between the two groups. We found that patients who had unplanned therapy had a higher local recurrence rate (41.7% vs. 21.5%; P = 0.049) and a shorter mean time for recurrence (8.90 vs. 14.59 months; P = 0.018). There was no significant difference between groups in the 5-year survival rate (56.3% vs.67.8%; P = 0.356), metastasis rate (45.8% vs. 30.4%; P = 0.125) and mean time to metastasis (23.18 vs.18.24 months; P = 0.396). Our findings suggest that unplanned therapy for extremity osteosarcoma can result in failure of local control. The use of supplementary interventions after unplanned therapy, such as neoadjuvant chemotherapy and limb salvage surgery, may explain the similar survival and metastasis rates between patients receiving unplanned therapy and those receiving standard treatment.
authors.affiliation: Orthopedic Department, The General Hospital of Jinan Military Commanding Region, Jinan, P.R.China.
authors.forename: Bing
authors.initials: B
authors.lastname: Wang
authors.affiliation: Orthopedic Department, The General Hospital of Jinan Military Commanding Region, Jinan, P.R.China.
authors.forename: Ming
authors.initials: M
authors.lastname: Xu
authors.affiliation: Orthopedic Department, The General Hospital of Jinan Military Commanding Region, Jinan, P.R.China.
authors.forename: Kai
authors.initials: K
authors.lastname: Zheng
authors.affiliation: Orthopedic Department, The General Hospital of Jinan Military Commanding Region, Jinan, P.R.China.
authors.forename: Xiuchun
authors.initials: X
authors.lastname: Yu
mesh_terms: D000293:Adolescent; D000328:Adult; D018572:Disease-Free Survival; D005260:Female; D005266:Femoral Neoplasms / Q000401:mortality* / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000401:mortality* / Q000473:pathology / Q000628:therapy*; D012516:Osteosarcoma / Q000401:mortality* / Q000473:pathology / Q000628:therapy*; D012189:Retrospective Studies; D016879:Salvage Therapy; D015996:Survival Rate; D013997:Time Factors