title: Giant primary malignant mesothelioma of the liver: A case report.
abstract: BACKGROUND
  Malignant mesothelioma is a rare neoplasm of mesothelial cells arising most frequently in the pleura or peritoneum and less frequently in the liver.
  
  
  METHODS
  We present a case of primary hepatic mesothelioma of 41year old woman. She had no history of asbestos exposure or cancer. Abdominal computed tomography (CT) showed 21cm intrahepatic mass in the right lobe with many cystic lesions and few small calcifications. Pathology showed a biphasic cellular pattern. In addition, the tumor cells were positive for Calretinin, Creatine Kinase (CK)5/6, CK7, CKAEI 1/3, Wilms Tumor protein (WT-1), and Vimentin, but were negative for Alpha Feto protein (AFP), Thrombotic Thrombocytopenic Purpura (TTP-1), Anti-Hepatocyte Specific Antigen (HSA), Synaptophysin, CK20, and Homeobox protein (CDx-2).
  
  
  CONCLUSIONS
  Primary intrahepatic mesothelioma (PIHMM) is not included in the classification of the World Health Organization classification of hepatic tumors. Mesothelial cells are not normally found in the liver, but some reported cases suggest it may grow from the mesothelial cells of the Glisson's capsule.
  
  
  CONCLUSIONS
  The probability of hepatic mesothelioma should not be ruled out, even in a young woman without a clear history of asbestos exposure.
authors.affiliation: Faculty of Medicine, Damascus University, Damascus, Syrian Arab Republic.
authors.forename: Ruba
authors.initials: R
authors.lastname: Haji Ali
authors.affiliation: Liver Transplantation and Hepatopancreaticobiliary Surgery, Department of General Surgery, American University of Beirut Medical Center, P.O. Box 11-0236, Beirut, Lebanon.
authors.forename: Mohamad
authors.initials: M
authors.lastname: Khalife
authors.affiliation: Liver Transplantation and Hepatopancreaticobiliary Surgery, Department of General Surgery, American University of Beirut Medical Center, P.O. Box 11-0236, Beirut, Lebanon.
authors.forename: Ghina
authors.initials: G
authors.lastname: El Nounou
authors.affiliation: Faculty of Medicine, Damascus University, Damascus, Syrian Arab Republic.
authors.forename: Ruba
authors.initials: R
authors.lastname: Zuhri Yafi
authors.affiliation: Liver Transplantation and Hepatopancreaticobiliary Surgery, Department of General Surgery, American University of Beirut Medical Center, P.O. Box 11-0236, Beirut, Lebanon.
authors.forename: Hussein
authors.initials: H
authors.lastname: Nassar
authors.affiliation: American University of Beirut, Faculty of Arts and Sciences, Department of Biology, P.O. Box 11-0236, Beirut, Lebanon.
authors.forename: Zeinab
authors.initials: Z
authors.lastname: Aidibe
authors.affiliation: Liver Transplantation and Hepatopancreaticobiliary Surgery, Department of General Surgery, American University of Beirut Medical Center, P.O. Box 11-0236, Beirut, Lebanon.
authors.forename: Randa
authors.initials: R
authors.lastname: Raad
authors.affiliation: Liver Transplantation and Hepatopancreaticobiliary Surgery, Department of General Surgery, American University of Beirut Medical Center, P.O. Box 11-0236, Beirut, Lebanon.
authors.forename: Rania
authors.initials: R
authors.lastname: Abou Eid
authors.affiliation: Liver Transplantation and Hepatopancreaticobiliary Surgery, Department of General Surgery, American University of Beirut Medical Center, P.O. Box 11-0236, Beirut, Lebanon. Electronic address: wf07@aub.edu.lb.
authors.forename: Walid
authors.initials: W
authors.lastname: Faraj
keywords: Case report; Liver; Malignant mesothelioma