title: MR Spectroscopy to Distinguish between Supratentorial Intraventricular Subependymoma and Central Neurocytoma.
abstract: OBJECTIVE
  The purpose of this study was to discriminate supratentorial intraventricular subependymoma (SIS) from central neurocytoma (CNC) using magnetic resonance spectroscopy (MRS).
  
  
  METHODS
  Single-voxel proton MRS using a 1.5T or 3T MR scanner from five SISs, five CNCs, and normal controls were evaluated. They were examined using a point-resolved spectroscopy. Automatically calculated ratios comparing choline (Cho), N-acetylaspartate (NAA), myoinositol (MI), and/or glycine (Gly) to creatine (Cr) were determined. Evaluation of Cr to unsuppressed water (USW) was also performed. Mann-Whitney U test was carried out to test the significance of differences in the metabolite ratios. Detectability of lactate (Lac) and alanine (Ala) was evaluated.
  
  
  RESULTS
  Although a statistically significant difference (P < 0.0001) was observed in Cho/Cr among SIS, control spectra, and CNC, no statistical difference was noted between SIS and control spectra (P = 0.11). Statistically significant differences were observed in NAA/Cr between SIS and CNC (P = 0.04) or control spectra (P < 0.0001). A statistically significant difference was observed in MI and/or Gly to Cr between SIS and control spectra (P = 0.03), and CNC and control spectra (P < 0.0006). There were no statistical differences between SIS and CNC for MI and/or Gly to Cr (P = 0.32). Significant statistical differences were found between SIS and control spectra (P < 0.0053), control spectra and CNC (P < 0.0016), and SIS and CNC (P < 0.0083) for Cr to USW. Lac inverted doublets were confirmed in two SISs. Triplets of Lac and Ala were detected in four spectra of CNC.
  
  
  CONCLUSIONS
  The present study showed that MRS can be useful in discriminating SIS from CNC.
authors.affiliation: Department of Advanced Medical Imaging, Graduate School of Medical Science, Kanazawa University.
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Ueda
authors.affiliation: Department of Radiology, Kanazawa University.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Aburano
authors.affiliation: Department of Radiology, Tonami General Hospital.
authors.forename: Yasuji
authors.initials: Y
authors.lastname: Ryu
authors.affiliation: Department of Radiology, Toyama City Hospital.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Yoshie
authors.affiliation: Department of Neurosurgery, Kanazawa University.
authors.forename: Mitsutoshi
authors.initials: M
authors.lastname: Nakada
authors.affiliation: Department of Neurosurgery, Kanazawa University.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Hayashi
authors.affiliation: Department of Advanced Medical Imaging, Graduate School of Medical Science, Kanazawa University.
authors.forename: Osamu
authors.initials: O
authors.lastname: Matsui
authors.affiliation: Department of Radiology, Kanazawa University.
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Gabata
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000000981:diagnostic imaging*; D005260:Female; D018315:Glioma, Subependymal / Q000000981:diagnostic imaging*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D018306:Neurocytoma / Q000000981:diagnostic imaging*; D055815:Young Adult
keywords: central neurocytoma; magnetic resonance spectroscopy; supratentorial intraventricular subependymoma