title: Identification of KIAA1199 as a Biomarker for Pancreatic Intraepithelial Neoplasia.
abstract: Pancreatic cancer is one of the most aggressive cancers and has an extremely poor prognosis. Despite recent progress in both basic and clinical research, most pancreatic cancers are detected at an incurable stage owing to the absence of disease-specific symptoms. Thus, developing novel approaches for detecting pancreatic cancer at an early stage is imperative. Our in silico and immunohistochemical analyses showed that KIAA1199 is specifically expressed in human pancreatic cancer cells and pancreatic intraepithelial neoplasia, the early lesion of pancreatic cancer, in a genetically engineered mouse model and in human patient samples. We also detected secreted KIAA1199 protein in blood samples obtained from pancreatic cancer mouse models, but not in normal mice. Furthermore, we found that assessing KIAA1199 autoantibody increased the sensitivity of detecting pancreatic cancer. These results indicate the potential benefits of using KIAA1199 as a biomarker for early-stage pancreatic cancer.
authors.affiliation: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
authors.forename: Han Na
authors.initials: HN
authors.lastname: Suh
authors.affiliation: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
authors.forename: Sohee
authors.initials: S
authors.lastname: Jun
authors.affiliation: Department of Molecular Biology, Pusan National University, Busan, Republic of Korea.
authors.forename: Ah-Young
authors.initials: AY
authors.lastname: Oh
authors.affiliation: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
authors.forename: Mrinal
authors.initials: M
authors.lastname: Srivastava
authors.affiliation: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
authors.forename: Sunhye
authors.initials: S
authors.lastname: Lee
authors.affiliation: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
authors.forename: Cullen M
authors.initials: CM
authors.lastname: Taniguchi
authors.affiliation: Department of Pathology, The University of Texas Medical School, Houston, TX, 77030, USA.
authors.forename: Songlin
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Internal Medicine, Gyeong-Sang National University Hospital, Jinju, Republic of Korea.
authors.forename: Won Sup
authors.initials: WS
authors.lastname: Lee
authors.affiliation: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
authors.forename: Junjie
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Molecular Biology, Pusan National University, Busan, Republic of Korea.
authors.forename: Bum-Joon
authors.initials: BJ
authors.lastname: Park
authors.affiliation: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.|Graduate School of Biomedical Sciences at Houston, Houston, TX, 77030, USA.|Program in Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
authors.forename: Jae-Il
authors.initials: JI
authors.lastname: Park
mesh_terms: D000208:Acute Disease; D000818:Animals; D001323:Autoantibodies / Q000096:biosynthesis / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood / Q000235:genetics*; D021441:Carcinoma, Pancreatic Ductal / Q000175:diagnosis / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D045744:Cell Line, Tumor; D002108:Ceruletide; D030541:Databases, Genetic; D004195:Disease Models, Animal; D042241:Early Diagnosis; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D006821:Hyaluronoglucosaminidase; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D010195:Pancreatitis / Q000139:chemically induced / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D011506:Proteins / Q000235:genetics* / Q000378:metabolism; D046888:Tissue Array Analysis
chemical_list: D001323:Autoantibodies; D014408:Biomarkers, Tumor; D011506:Proteins; D002108:Ceruletide; C491433:CEMIP protein, human; D006821:Hyaluronoglucosaminidase