title: Dynamic thiol/disulfide homeostasis in children with attention deficit hyperactivity disorder and its relation with disease subtypes.
abstract: The aim of this study was to evaluate a novel oxidative stress marker (thiol/disulfide homeostasis) in attention deficit hyperactivity disorder (ADHD) children for the first time in literature.
  
  
  
  Ninety children with ADHD diagnosed according to DSM-V and as control group, 65 healthy children were included to the study. Native thiol, total thiol, disulfide, disulfide/native thiol, disulfide/total thiol were compared between the groups.
  
  
  
  Total and native thiol levels were significantly higher whereas the disulfide/native thiol ratios were significantly lower in children with ADHD. ADHD combined type appeared to have higher disulfide, disulfide/native thiol and disulfide/total thiol ratios compared to other subtypes. Disulfide levels of the males with ADHD were significantly higher than those of the females with ADHD.
  
  
  
  This study suggests that thiol/disulfide homeostasis is abnormal in children with ADHD. It may be used as a novel OS marker in ADHD children because it is easy, practical, fully automated and relatively inexpensive.
authors.affiliation: Adnan Menderes University, Faculty of Medicine, Department of Child and Adolescent Psychiatry, Aydın, Turkey. Electronic address: snuravcil@yahoo.com.tr.
authors.forename: Sibelnur
authors.initials: S
authors.lastname: Avcil
authors.affiliation: Adnan Menderes University, Faculty of Medicine, Department of Pediatric Allergy and Immunology, Aydın, Turkey.
authors.forename: Pınar
authors.initials: P
authors.lastname: Uysal
authors.affiliation: Adnan Menderes University, Faculty of Medicine, Department of Emergency Medicine, Aydın, Turkey.
authors.forename: Mucahit
authors.initials: M
authors.lastname: Avcil
authors.affiliation: Yıldırım Beyazıd University, Faculty of Medicine, Department of Clinical Biochemistry, Ankara, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Alışık
authors.affiliation: Yıldırım Beyazıd University, Faculty of Medicine, Department of Clinical Biochemistry, Ankara, Turkey.
authors.forename: Cemile
authors.initials: C
authors.lastname: Biçer
mesh_terms: D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000097:blood* / Q000175:diagnosis; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002648:Child; D004220:Disulfides / Q000097:blood*; D005260:Female; D006706:Homeostasis; D006801:Humans; D008297:Male; D012727:Sex Characteristics; D013438:Sulfhydryl Compounds / Q000097:blood*
chemical_list: D015415:Biomarkers; D004220:Disulfides; D013438:Sulfhydryl Compounds