title: Relative contribution of muscle and liver insulin resistance to dysglycemia in postmenopausal overweight and obese women: A MONET group study.
abstract: OBJECTIVE
  The relative contribution of muscle and liver insulin resistance (IR) in the development of dysglycemia and metabolic abnormalities is difficult to establish. The present study aimed to investigate the relative contribution of muscle IR vs. liver IR to dysglycemia in non-diabetic overweight or obese postmenopausal women and to determine differences in body composition and cardiometabolic indicators associated with hepatic or muscle IR.
  
  
  METHODS
  Secondary analysis of 156 non-diabetic overweight or obese postmenopausal women. Glucose tolerance was measured using an oral glucose tolerance test. Whole-body insulin sensitivity (IS) was determined as glucose disposal rate during a euglycemic-hyperinsulinemic clamp. Muscle and liver IR have been calculated using Abdul-Ghani et al. OGTT-derived formulas. Participant's body compositions as well as cardiometabolic risk indicators were also determined.
  
  
  RESULTS
  Overall, 57 (36.5%) of patients had dysglycemia, among them 25 (16.0%); 21 (13.5%); 11 (7.1%) had impaired fasting glycemia, impaired glucose tolerance and combined glucose intolerance respectively. Fifty-three (34.0%) participants were classified as combined IS while on the opposite 51 participants (32.7%) were classified as combined IR and 26 (16.7%) participants had either muscle IR or liver IR. For similar body mass index and total fat mass, participants with liver IR were more likely to have lower whole-body IS, dysglycemia and higher visceral fat, liver fat index, triglycerides and alanine aminotransferase than participants with muscle IR.
  
  
  CONCLUSIONS
  In the present study, the presence of liver IR is associated with a higher prevalence of dysglycemia, ectopic fat accumulation and metabolic abnormalities than muscle IR.
authors.affiliation: Department of Nutrition, Université de Montréal, Montréal, Québec, Canada; Department of Medicine, Institut de Recherches Cliniques de Montréal (IRCM), Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada.
authors.forename: Belinda
authors.initials: B
authors.lastname: Elisha
authors.affiliation: Centre de Recherche en Nutrition Humaine, Rhône Alpes, Centre Hospitalier Lyon Sud, 69310 Pierre-Bénite, France.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Disse
authors.affiliation: Department of Nutrition, Université de Montréal, Montréal, Québec, Canada; Department of Medicine, Institut de Recherches Cliniques de Montréal (IRCM), Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada.
authors.forename: Katherine
authors.initials: K
authors.lastname: Chabot
authors.affiliation: Department of Nutrition, Université de Montréal, Montréal, Québec, Canada; Department of Medicine, Institut de Recherches Cliniques de Montréal (IRCM), Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada.
authors.forename: Nadine
authors.initials: N
authors.lastname: Taleb
authors.affiliation: Institut de Recherche de l'Hôpital Montfort, Ottawa, Ontario, Canada; School of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada.
authors.forename: Denis
authors.initials: D
authors.lastname: Prud'homme
authors.affiliation: Department of Medicine, Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada.
authors.forename: Sophie
authors.initials: S
authors.lastname: Bernard
authors.affiliation: Department of Nutrition, Université de Montréal, Montréal, Québec, Canada; Department of Medicine, Institut de Recherches Cliniques de Montréal (IRCM), Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada.
authors.forename: Rémi
authors.initials: R
authors.lastname: Rabasa-Lhoret
authors.affiliation: Service de Biochimie et Hormonologie, AP-HP, Hôpital Tenon, UF Biomarqueurs Inflammatoires et Métaboliques, 75020 Paris, France; Inserm UMR_S938, ICAN, CDR Saint-Antoine, 75012 Paris, France; UMR_S 938, Sorbonne Universités, UPMC Université Paris 06, 75005 Paris, France. Electronic address: jean-philippe.bastard@tnn.aphp.fr.
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Bastard
mesh_terms: D001786:Blood Glucose / Q000378:metabolism*; D001823:Body Composition / Q000502:physiology*; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D015309:Glucose Clamp Technique; D018149:Glucose Intolerance / Q000150:complications / Q000378:metabolism; D044882:Glucose Metabolism Disorders / Q000150:complications / Q000378:metabolism*; D005951:Glucose Tolerance Test; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008099:Liver / Q000378:metabolism; D018482:Muscle, Skeletal / Q000378:metabolism; D009765:Obesity / Q000150:complications / Q000378:metabolism*; D050177:Overweight / Q000150:complications / Q000378:metabolism*; D017698:Postmenopause / Q000378:metabolism
chemical_list: D001786:Blood Glucose
keywords: Glucose homeostasis; Homéostasie du glucose; Insulinorésistance hépatique; Insulinorésistance musculaire; Liver insulin resistance; Muscle insulin resistance; Obesity; Obésité