title: High Antibacterial Activity of Functionalized Chemically Exfoliated MoS2.
abstract: In view of the implications of inherent resistance of pathogenic bacteria, especially ESKAPE pathogens toward most of the commercially available antibiotics and the importance of these bacteria-induced biofilm formation leading to chronic infection, it is important to develop new-generation synthetic materials with greater efficacy toward antibacterial property. In addressing this issue, this paper reports a proof-of-principle study to evaluate the potential of functionalized two-dimensional chemically exfoliated MoS2(ce-MoS2) toward inhibitory and bactericidal property against two representative ESKAPE pathogenic strain-a Gram-positive Staphylococcus aureus (MRSA) and a Gram-negative Pseudomonas aeruginosa. More significantly, the mechanistic study establishes a different extent of oxidative stress together with rapid membrane depolarization in contact with ce-MoS2having ligands of varied charge and hydrophobicity. The implication of our results is discussed in the light of the lack of survivability of planktonic bacteria and biofilm destruction in vitro. A comparison with widely used small molecules and other nanomaterial-based therapeutics conclusively establishes a better efficacy of 2D ce-MoS2as a new class of antibiotics.
authors.affiliation: Department of Organic Chemistry, ‡Laboratory for Biomaterials, Materials Research Centre, and ∥Centre for Biosystems Science and Engineering, Indian Institute of Science , Bangalore 560012, India.
authors.forename: Subhendu
authors.initials: S
authors.lastname: Pandit
authors.affiliation: Department of Organic Chemistry, ‡Laboratory for Biomaterials, Materials Research Centre, and ∥Centre for Biosystems Science and Engineering, Indian Institute of Science , Bangalore 560012, India.
authors.forename: Subbaraj
authors.initials: S
authors.lastname: Karunakaran
authors.affiliation: Department of Organic Chemistry, ‡Laboratory for Biomaterials, Materials Research Centre, and ∥Centre for Biosystems Science and Engineering, Indian Institute of Science , Bangalore 560012, India.
authors.forename: Sunil Kumar
authors.initials: SK
authors.lastname: Boda
authors.affiliation: Department of Organic Chemistry, ‡Laboratory for Biomaterials, Materials Research Centre, and ∥Centre for Biosystems Science and Engineering, Indian Institute of Science , Bangalore 560012, India.
authors.forename: Bikramjit
authors.initials: B
authors.lastname: Basu
authors.affiliation: Department of Organic Chemistry, ‡Laboratory for Biomaterials, Materials Research Centre, and ∥Centre for Biosystems Science and Engineering, Indian Institute of Science , Bangalore 560012, India.
authors.forename: Mrinmoy
authors.initials: M
authors.lastname: De
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry*; D018441:Biofilms; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa; D013203:Staphylococcal Infections; D013211:Staphylococcus aureus
chemical_list: D000900:Anti-Bacterial Agents
keywords: ESKAPE pathogens; antibiotics; ce-MoS2; membrane depolarization; nanomaterials; oxidative stress; surface functionalization