title: Surveillance for neoplasia in the pancreas.
abstract: Despite its low incidence in the general population, pancreatic cancer is one of the leading causes of cancer-related mortality. Survival greatly depends on operability, but most patients present with unresectable disease. Therefore, there is great interest in the early detection of pancreatic cancer and its precursor lesions by surveillance. Worldwide, several programs have been initiated for individuals at high risk for pancreatic cancer. Their first results suggest that surveillance in high-risk individuals is feasible, but their effectiveness in decreasing mortality remains to be proven. This review will discuss which individuals are eligible for surveillance, which lesions are aimed to be detected, and which surveillance modalities are being used in current clinical practice. Furthermore, it addresses the management of abnormalities found during surveillance and topics for future research.
authors.affiliation: Department of Gastroenterology and Hepatology, Erasmus University Medical Center, 's Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands. Electronic address: k.overbeek@erasmusmc.nl.
authors.forename: Kasper A
authors.initials: KA
authors.lastname: Overbeek
authors.affiliation: Department of Gastroenterology and Hepatology, Erasmus University Medical Center, 's Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands. Electronic address: d.cahen@erasmusmc.nl.
authors.forename: Djuna L
authors.initials: DL
authors.lastname: Cahen
authors.affiliation: Division of Gastroenterology and Hepatology, The Johns Hopkins Medical Institutions, 1800 Orleans St., Blalock 407, Baltimore, MD, 21287, USA. Electronic address: mcanto1@jhmi.edu.
authors.forename: Marcia Irene
authors.initials: MI
authors.lastname: Canto
authors.affiliation: Department of Gastroenterology and Hepatology, Erasmus University Medical Center, 's Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands. Electronic address: m.bruno@erasmusmc.nl.
authors.forename: Marco J
authors.initials: MJ
authors.lastname: Bruno
mesh_terms: D055088:Early Detection of Cancer; D020022:Genetic Predisposition to Disease; D006801:Humans; D009386:Neoplastic Syndromes, Hereditary / Q000175:diagnosis* / Q000235:genetics; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000235:genetics; D011159:Population Surveillance; D012307:Risk Factors
keywords: Early detection of cancer; Genetic predisposition to disease; Hereditary; Neoplastic syndromes; Pancreatic cyst; Pancreatic neoplasms