title: CYP2D6 polymorphisms and their influence on risperidone treatment.
abstract: Cytochrome P450 enzyme especiallyCYP2D6plays a major role in biotransformation. The interindividual variations of treatment response and toxicity are influenced by the polymorphisms of this enzyme. This review emphasizes the effect ofCYP2D6polymorphisms in risperidone treatment in terms of basic knowledge, pharmacogenetics, effectiveness, adverse events, and clinical practice. Although the previous studies showed different results, the effective responses in risperidone treatment depend on the CYP2D6 polymorphisms. Several studies suggested thatCYP2D6polymorphisms were associated with plasma concentration of risperidone, 9-hydroxyrisperidone, and active moiety but did not impact on clinical outcomes. In addition, CYP2D6 poor metabolizer showed more serious adverse events such as weight gain and prolactin than other predicted phenotype groups. The knowledge of pharmacogenomics ofCYP2D6in risperidone treatment is increasing, and it can be used for the development of personalized medication in term of genetic-based dose recommendation. Moreover, the effects of many factors in risperidone treatment are still being investigated. Both theCYP2D6genotyping and therapeutic drug monitoring are the important steps to complement the genetic-based risperidone treatment.
authors.affiliation: Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, Faculty of Medicine Ramathibodi Hospital.
authors.forename: Apichaya
authors.initials: A
authors.lastname: Puangpetch
authors.affiliation: Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, Faculty of Medicine Ramathibodi Hospital.
authors.forename: Natchaya
authors.initials: N
authors.lastname: Vanwong
authors.affiliation: Molecular Medicine, Faculty of Science, Mahidol University, Bangkok, Thailand.
authors.forename: Nopphadol
authors.initials: N
authors.lastname: Nuntamool
authors.affiliation: Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, Faculty of Medicine Ramathibodi Hospital.
authors.forename: Yaowaluck
authors.initials: Y
authors.lastname: Hongkaew
authors.affiliation: Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, Faculty of Medicine Ramathibodi Hospital.
authors.forename: Monpat
authors.initials: M
authors.lastname: Chamnanphon
authors.affiliation: Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, Faculty of Medicine Ramathibodi Hospital.
authors.forename: Chonlaphat
authors.initials: C
authors.lastname: Sukasem
keywords: CYP2D6; adverse drug reaction; pharmacodynamics; pharmacogenetics; pharmacokinetics; polymorphisms; risperidone