title: Anatomical location differences between mutated and wild-type isocitrate dehydrogenase 1 in low-grade gliomas.
abstract: Anatomical location of gliomas has been considered as a factor implicating the contributions of a specific precursor cells during the tumor growth. Isocitrate dehydrogenase 1 (IDH1) is a pathognomonic biomarker with a significant impact on the development of gliomas and remarkable prognostic effect. The correlation between anatomical location of tumor and IDH1 states for low-grade gliomas was analyzed quantitatively in this study. Ninety-two patients diagnosed of low-grade glioma pathologically were recruited in this study, including 65 patients with IDH1-mutated glioma and 27 patients with wide-type IDH1. A convolutional neural network was designed to segment the tumor from three-dimensional magnetic resonance imaging images. Voxel-based lesion symptom mapping was then employed to study the tumor location distribution differences between gliomas with mutated and wild-type IDH1. In order to characterize the location differences quantitatively, the Automated Anatomical Labeling Atlas was used to partition the standard brain atlas into 116 anatomical volumes of interests (AVOIs). The percentages of tumors with different IDH1 states in 116 AVOIs were calculated and compared. Support vector machine and AdaBoost algorithms were used to estimate the IDH1 status based on the 116 location features of each patient. Experimental results proved that the quantitative tumor location measurement could be a very important group of imaging features in biomarker estimation based on radiomics analysis of glioma.
authors.affiliation: a Department of Electronic Engineering , Fudan University , Shanghai , China.|b Key laboratory of Medical Imaging Computing and Computer Assisted Intervention of Shanghai , Shanghai , China.
authors.forename: Jinhua
authors.initials: J
authors.lastname: Yu
authors.affiliation: c Department of Neurosurgery, Huashan Hospital , Fudan University , Shanghai , China.
authors.forename: Zhifeng
authors.initials: Z
authors.lastname: Shi
authors.affiliation: a Department of Electronic Engineering , Fudan University , Shanghai , China.
authors.forename: Chunhong
authors.initials: C
authors.lastname: Ji
authors.affiliation: a Department of Electronic Engineering , Fudan University , Shanghai , China.
authors.forename: Yuxi
authors.initials: Y
authors.lastname: Lian
authors.affiliation: a Department of Electronic Engineering , Fudan University , Shanghai , China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: c Department of Neurosurgery, Huashan Hospital , Fudan University , Shanghai , China.
authors.forename: Liang
authors.initials: L
authors.lastname: Chen
authors.affiliation: c Department of Neurosurgery, Huashan Hospital , Fudan University , Shanghai , China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Mao
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology*; D005260:Female; D005910:Glioma / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology*; D006801:Humans; D007521:Isocitrate Dehydrogenase / Q000235:genetics*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009154:Mutation; D060787:Neoplasm Grading
chemical_list: D007521:Isocitrate Dehydrogenase; C543588:IDH1 protein, human
keywords: IDH1; Low-grade glioma; MRI; anatomic location; image analysis