title: Canola oil rich in oleic acid improves diastolic heart function in diet-induced obese rats.
abstract: Obesity is a leading cause of cardiovascular disease. It directly affects heart structure and function and contributes to heart failure. Diet is a major factor involved in the development of obesity along with genetic factors. We examined the effects of monounsaturated and polyunsaturated fatty acid-rich oils on cardiac structure and function in the diet-induced rodent model of obesity (DIO). Obese prone (OP) rats were fed a high-fat diet (HF; 55% of kcal) for 12 weeks; Sprague-Dawley rats fed commercial chow served as control. Echocardiography was performed to assess the cardiac structure and function in all rats at 12 weeks. OP rats fed the HF diet showed significant impairment in diastolic function compared to control rats. The HF diet containing high oleic canola oil significantly improved diastolic function of OP rats compared to the HF diet with lard. In conclusion, canola oil rich in oleic acid, when incorporated into an HF diet, prevents the development of diastolic dysfunction in DIO rats.
authors.affiliation: Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, MB, Canada.|Agriculture and Agri-Food Canada, Winnipeg, MB, Canada.
authors.forename: Sijo Joseph
authors.initials: SJ
authors.lastname: Thandapilly
authors.affiliation: Canadian Centre for Agri-Food Research in Health and Medicine, Winnipeg, MB, Canada.|Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, MB, Canada.|St. Boniface Albrechtsen Research Centre, Winnipeg, MB, Canada.
authors.forename: Pema
authors.initials: P
authors.lastname: Raj
authors.affiliation: Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, MB, Canada.
authors.forename: Xavier Lieben
authors.initials: XL
authors.lastname: Louis
authors.affiliation: Canadian Centre for Agri-Food Research in Health and Medicine, Winnipeg, MB, Canada.
authors.forename: Danielle
authors.initials: D
authors.lastname: Perera
authors.affiliation: Canadian Centre for Agri-Food Research in Health and Medicine, Winnipeg, MB, Canada.
authors.forename: Prasanga
authors.initials: P
authors.lastname: Yamanagedara
authors.affiliation: Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, MB, Canada.|Canadian Centre for Agri-Food Research in Health and Medicine, Winnipeg, MB, Canada.|Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, MB, Canada.|St. Boniface Albrechtsen Research Centre, Winnipeg, MB, Canada.
authors.forename: Peter
authors.initials: P
authors.lastname: Zahradka
authors.affiliation: Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, MB, Canada. ctaylor@sbrc.ca.|Canadian Centre for Agri-Food Research in Health and Medicine, Winnipeg, MB, Canada. ctaylor@sbrc.ca.|Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, MB, Canada. ctaylor@sbrc.ca.|St. Boniface Albrechtsen Research Centre, Winnipeg, MB, Canada. ctaylor@sbrc.ca.
authors.forename: Carla G
authors.initials: CG
authors.lastname: Taylor
authors.affiliation: Agriculture and Agri-Food Canada, Winnipeg, MB, Canada. tnetticadan@sbrc.ca.|Canadian Centre for Agri-Food Research in Health and Medicine, Winnipeg, MB, Canada. tnetticadan@sbrc.ca.|Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, MB, Canada. tnetticadan@sbrc.ca.|St. Boniface Albrechtsen Research Centre, Winnipeg, MB, Canada. tnetticadan@sbrc.ca.
authors.forename: Thomas
authors.initials: T
authors.lastname: Netticadan
mesh_terms: D000818:Animals; D059305:Diet, High-Fat / Q000009:adverse effects*; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D054144:Heart Failure, Diastolic / Q000188:drug therapy*; D009765:Obesity / Q000503:physiopathology*; D019301:Oleic Acid / Q000494:pharmacology*; D010938:Plant Oils / Q000494:pharmacology*; D000074262:Rapeseed Oil; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D010938:Plant Oils; D000074262:Rapeseed Oil; D019301:Oleic Acid
keywords: Diastolic dysfunction; Diet-induced obesity; Edible oil