title: Recent Progress in Electrochemical Biosensors for Glycoproteins.
abstract: This review provides an overview of recent progress in the development of electrochemical biosensors for glycoproteins. Electrochemical glycoprotein sensors are constructed by combining metal and carbon electrodes with glycoprotein-selective binding elements including antibodies, lectin, phenylboronic acid and molecularly imprinted polymers. A recent trend in the preparation of glycoprotein sensors is the successful use of nanomaterials such as graphene, carbon nanotube, and metal nanoparticles. These nanomaterials are extremely useful for improving the sensitivity of glycoprotein sensors. This review focuses mainly on the protocols for the preparation of glycoprotein sensors and the materials used. Recent improvements in glycoprotein sensors are discussed by grouping the sensors into several categories based on the materials used as recognition elements.
authors.affiliation: Graduate School of Engineering and Science, Akita University, 1-1 Tegatagaluenn-machi, Akita 010-8502, Japan. uakiba@gipc.akita-u.ac.jp.
authors.forename: Uichi
authors.initials: U
authors.lastname: Akiba
authors.affiliation: Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramakim, Sendai 980-8578, Japan. junanzai@mail.pharm.tohoku.ac.jp.
authors.forename: Jun-Ichi
authors.initials: JI
authors.lastname: Anzai
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D001897:Boronic Acids / Q000737:chemistry; D055664:Electrochemical Techniques / Q000379:methods*; D006023:Glycoproteins / Q000032:analysis*; D054802:Molecular Imprinting; D049329:Nanostructures / Q000737:chemistry
chemical_list: D001897:Boronic Acids; D006023:Glycoproteins; C010686:benzeneboronic acid
keywords: biosensor; electrochemical sensor; glycoprotein; immunosensor; lectin; molecularly imprinted polymers; phenylboronic acid