title: Pathophysiological Significance of Store-Operated Calcium Entry in Megakaryocyte Function: Opening New Paths for Understanding the Role of Calcium in Thrombopoiesis.
abstract: Store-Operated Calcium Entry (SOCE) is a universal calcium (Ca2+) influx mechanism expressed by several different cell types. It is now known that Stromal Interaction Molecule (STIM), the Ca2+sensor of the intracellular compartments, together with Orai and Transient Receptor Potential Canonical (TRPC), the subunits of Ca2+permeable channels on the plasma membrane, cooperate in regulating multiple cellular functions as diverse as proliferation, differentiation, migration, gene expression, and many others, depending on the cell type. In particular, a growing body of evidences suggests that a tight control of SOCE expression and function is achieved by megakaryocytes along their route from hematopoietic stem cells to platelet production. This review attempts to provide an overview about the SOCE dynamics in megakaryocyte development, with a focus on most recent findings related to its involvement in physiological and pathological thrombopoiesis.
authors.affiliation: Department of Molecular Medicine, University of Pavia, 27100 Pavia, Italy. christian.dibuduo@unipv.it.|Laboratory of Biotechnology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Matteo Foundation, 27100 Pavia, Italy. christian.dibuduo@unipv.it.
authors.forename: Christian A
authors.initials: CA
authors.lastname: Di Buduo
authors.affiliation: Department of Molecular Medicine, University of Pavia, 27100 Pavia, Italy. alessandra.balduini@unipv.it.|Laboratory of Biotechnology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Matteo Foundation, 27100 Pavia, Italy. alessandra.balduini@unipv.it.|Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA. alessandra.balduini@unipv.it.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Balduini
authors.affiliation: Laboratory of General Physiology, Department of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, 27100 Pavia, Italy. francesco.moccia@unipv.it.
authors.forename: Francesco
authors.initials: F
authors.lastname: Moccia
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D006801:Humans; D008533:Megakaryocytes / Q000378:metabolism*; D008954:Models, Biological; D050052:TRPC Cation Channels / Q000378:metabolism; D034061:Thrombopoiesis
chemical_list: D050052:TRPC Cation Channels; D002118:Calcium
keywords: SOCE; calcium; calreticulin; megakaryocyte; myelofibrosis; platelet production