title: High-intensity focused ultrasonic ablation of sacral chordoma is feasible: a series of four cases and details of a national clinical trial.
abstract: High-intensity focused ultrasound describes the use of high-intensity focused ultrasound (HIFU) to ablate tumours without requiring an incision or other invasive procedure. This technique has been trialled on a range of tumours including uterine fibroids, prostate, liver and renal cancer. We describe our experience of using HIFU to ablate sacral chordoma in four patients with advanced tumours. Patients were treated under general anaesthetic or sedation using an ultrasound-guided HIFU device. HIFU therapy was associated with a reduction in tumour volume over time in three patients for whom follow up scans were available. Tumour necrosis was reliably demonstrated in two of the three patients. We have established a national trial to assess if HIFU may improve long-term outcome from sacral chordoma, details are given.
authors.affiliation: a Department of Neurosurgery , West Wing, John Radcliffe Hospital , Oxford , UK.|b Nuffield Department of Surgical Sciences , University of Oxford , Oxford , UK.
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Gillies
authors.affiliation: b Nuffield Department of Surgical Sciences , University of Oxford , Oxford , UK.
authors.forename: Paul C
authors.initials: PC
authors.lastname: Lyon
authors.affiliation: b Nuffield Department of Surgical Sciences , University of Oxford , Oxford , UK.|c HIFU Unit , Churchill Hospital , Headington, Oxford , UK.
authors.forename: Feng
authors.initials: F
authors.lastname: Wu
authors.affiliation: b Nuffield Department of Surgical Sciences , University of Oxford , Oxford , UK.
authors.forename: Tom
authors.initials: T
authors.lastname: Leslie
authors.affiliation: d Department of Radiology , Churchill Hospital , Oxford , UK.
authors.forename: Daniel Y
authors.initials: DY
authors.lastname: Chung
authors.affiliation: d Department of Radiology , Churchill Hospital , Oxford , UK.
authors.forename: Fergus
authors.initials: F
authors.lastname: Gleeson
authors.affiliation: b Nuffield Department of Surgical Sciences , University of Oxford , Oxford , UK.|c HIFU Unit , Churchill Hospital , Headington, Oxford , UK.
authors.forename: David
authors.initials: D
authors.lastname: Cranston
authors.affiliation: a Department of Neurosurgery , West Wing, John Radcliffe Hospital , Oxford , UK.
authors.forename: Stana
authors.initials: S
authors.lastname: Bojanic
mesh_terms: D000293:Adolescent; D000768:Anesthesia, General; D002648:Child; D002675:Child, Preschool; D002817:Chordoma / Q000601:surgery*; D005240:Feasibility Studies; D005260:Female; D057086:High-Intensity Focused Ultrasound Ablation / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D007223:Infant; D008297:Male; D009336:Necrosis / Q000209:etiology; D010348:Patient Care Team; D011183:Postoperative Complications / Q000453:epidemiology; D012445:Sacrococcygeal Region / Q000601:surgery*; D013125:Spinal Neoplasms / Q000601:surgery*; D016896:Treatment Outcome
keywords: Sacral chordoma; ablative therapy; high-intensity focused ultrasound; national clinical trial