title: The declined levels of inflammatory cytokines related with weaning rate during period of septic patients using ventilators.
abstract: BACKGROUND
  Approximately 50% of patients with sepsis-induced acute lung injury and acute respiratory distress syndrome require mechanical ventilation. Patients with extended mechanical ventilator use routinely develop reinfections, which increases hospital stay, mortality, and health care cost. Some studies have pointed out inflammatory factors concentrations can affect ventilator weaning, but do not indicate changed inflammatory factors related to ventilator weaning during using ventilators.
  
  
  OBJECTIVE
  This study aimed to investigate during period of septic patients using ventilators, the inflammatory cytokines concentrations related with weaning rate.
  
  
  METHODS
  Blood was collected from 35 septic patients before and during ventilator use on days 1, 7, 14, and 21 (or weaning).
  
  
  RESULTS
  58.3% (N = 20) of septic patients with mechanical ventilators were weaned successfully within 21 days (ventilator weaned group, VW), 16.7% (N = 6) did not wean within 21 days (ventilator dependent group, VD), and 25% died (death group) in hospital. Before ventilator use, higher C-reactive protein (CRP), IL-6, and IL-8 levels were measured in the death group than in all other groups (P < .05). During ventilator use, CRP, IL-6, and IL-8 concentrations declined significantly in VW and VD patients (P < .05). In addition, IL-6 concentrations in the VW group were significantly lower than in the VD group at 14 and 21 days (P < .05).
  
  
  CONCLUSIONS
  The factors of ventilators weaning successfully such as disease control, nutritional status, and so on. The declined levels of serum inflammatory cytokines, especially IL-6, improved inflammation status might be one factor of successfully weaning during septic patients on ventilators.
authors.affiliation: Department of Pulmonary Medicine, Kuang-Tien General Hospital, Taichung, Taiwan, Republic of China.
authors.forename: Chao-Huei
authors.initials: CH
authors.lastname: Yang
authors.affiliation: Department of Critical Care Medicine, Kuang-Tien General Hospital, Taichung, Taiwan, Republic of China.
authors.forename: Jung-Lung
authors.initials: JL
authors.lastname: Hsiao
authors.affiliation: Department of Internal Medicine, Kuang-Tien General Hospital, Taichung, Taiwan, Republic of China.
authors.forename: Ming-Feng
authors.initials: MF
authors.lastname: Wu
authors.affiliation: Department of Nursing, Kuang-Tien General Hospital, Taichung, Taiwan, Republic of China.
authors.forename: Mei-Hua
authors.initials: MH
authors.lastname: Lu
authors.affiliation: Department of Nursing, Kuang-Tien General Hospital, Taichung, Taiwan, Republic of China.
authors.forename: Hui-Ming
authors.initials: HM
authors.lastname: Chang
authors.affiliation: Department of Internal Medicine, Kuang-Tien General Hospital, Taichung, Taiwan, Republic of China.|Department of Nutrition and Institute of BioMedical Nutrition, Hungkuang University, Taichung, Taiwan, Republic of China.
authors.forename: Wang-Sheng
authors.initials: WS
authors.lastname: Ko
authors.affiliation: Department of Nutrition and Institute of BioMedical Nutrition, Hungkuang University, Taichung, Taiwan, Republic of China.
authors.forename: Ya-Ling
authors.initials: YL
authors.lastname: Chiou
mesh_terms: D000328:Adult; D000368:Aged; D015331:Cohort Studies; D016207:Cytokines / Q000032:analysis / Q000097:blood*; D004636:Emergency Service, Hospital; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods; D011379:Prognosis; D012121:Respiration, Artificial / Q000379:methods*; D012128:Respiratory Distress Syndrome / Q000097:blood / Q000209:etiology / Q000401:mortality / Q000628:therapy*; D018570:Risk Assessment; D018805:Sepsis / Q000150:complications* / Q000175:diagnosis / Q000401:mortality / Q000628:therapy; D015996:Survival Rate; D015300:Ventilator Weaning / Q000706:statistics & numerical data*
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators
keywords: inflammatory factors; sepsis; ventilator dependent; ventilator weaning