title: Platelet Function and Other Indices of Hemostasis in Chronic Liver Disease.
abstract: BACKGROUND
  Bleeding time has been used for a long time as a global test of platelet function. Due to a number of pitfalls the test has been losing popularity. This study was designed to determine the prevalence of prolonged bleeding time in Nigerians with chronic liver disease in relation to other indices of hemostasis.
  
  
  METHODS
  Bleeding time, platelet count, prothrombin time (PT) and activated partial thromboplastin time (aPTT) were determined in patients with chronic liver disease seen over a twenty-eight-month period. Liver disease severity was graded using Child's score.
  
  
  RESULTS
  Only 14 of 164 (8.5%) patients with chronic liver disease had prolonged bleeding time while 60 patients (36.6%) had significantly prolonged PT. Thirty seven patients (22.6%) had prolonged aPTT. Bleeding time showed positive correlation with PT and aPTT but negative correlation with platelet count.
  
  
  CONCLUSIONS
  Bleeding time is not sensitive in detecting disorders of hemostasis in patients with chronic liver disease although it correlates significantly with other indices of hemostasis.
authors.affiliation: Department of Medicine, University of Nigeria Teaching Hospital Ituku/Ozalla, Enugu, Nigeria.
authors.forename: Sylvester Chuks
authors.initials: SC
authors.lastname: Nwokediuko
authors.affiliation: Department of Hematology, University of Nigeria Teaching Hospital Ituku/Ozalla, Enugu, Nigeria.
authors.forename: Obike Godswill
authors.initials: OG
authors.lastname: Ibegbulam
keywords: Bleeding time; Hemostasis; Liver disease; Partial thromboplastin time; Prothrombin time