title: Evaluation of arterial stiffness and cardiac function in patients with vascular erectile dysfunction: acute effects of phosphodiesterase-5 inhibitor tadalafil.
abstract: This study aimed to detect endothelial dysfunction in erectile dysfunction (ED) patients free from cardiovascular diseases or atherosclerotic risk factors and to evaluate acute effects of phosphodiesterase-5 inhibitor tadalafil on endothelial dysfunction and cardiac function. Thirty ED patients and 20 healthy male subjects (mean ages: 48.7±11.7 and 48.3±8.7 years, respectively) were enrolled. Endothelium functions were assessed by applanation tonometry. Aortic stiffness and cardiac function were evaluated by transthoracic echocardiography. Pulse pressure was greater in the ED group (P<0.05), whereas aortic strain and aortic distensibility were significantly lower (P<0.001). Treatment with tadalafil reduced pulse pressure (P=0.0179), systolic blood pressure (P=0.001) and diastolic blood pressure (P=0.054) and increased aortic distensibility (P=0.001) and aortic strain (P=0.003) in the ED group. Tadalafil administration also increased large artery and small artery elasticity indices that were reduced in the ED group at baseline (P=0.02 and 0.003, respectively). Systemic vascular disease and compromised left ventricular diastolic function (LVDF) were present in ED patients with no known atherosclerotic risk factors and cardiac diseases. Tadalafil positively affected arterial stiffness and LVDF.
authors.affiliation: Department of Cardiology, Uludag University, Bursa, Turkey.
authors.forename: O
authors.initials: O
authors.lastname: Özdabakoğlu
authors.affiliation: Department of Cardiology, Uludag University, Bursa, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Güllülü
authors.affiliation: Department of Cardiology, Uludag University, Bursa, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Sağ
authors.affiliation: Department of Cardiology, Uludag University, Bursa, Turkey.
authors.forename: T
authors.initials: T
authors.lastname: Şentürk
authors.affiliation: Department of Urology, Uludag University, Bursa, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Kiliçarslan
authors.affiliation: Department of Cardiology, Uludag University, Bursa, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Tütüncü
authors.affiliation: Department of Cardiology, Uludag University, Bursa, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Keçebaş
authors.affiliation: Department of Cardiology, Uludag University, Bursa, Turkey.
authors.forename: I
authors.initials: I
authors.lastname: Baran
authors.affiliation: Department of Cardiology, Uludag University, Bursa, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Aydinlar
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003971:Diastole; D004730:Endothelium, Vascular / Q000187:drug effects*; D007172:Erectile Dysfunction / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D058986:Phosphodiesterase 5 Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D013599:Systole; D000068581:Tadalafil / Q000494:pharmacology* / Q000627:therapeutic use; D059289:Vascular Stiffness / Q000187:drug effects*; D016277:Ventricular Function, Left / Q000187:drug effects*
chemical_list: D058986:Phosphodiesterase 5 Inhibitors; D000068581:Tadalafil