title: Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery in vivo.
abstract: Delivery is the key challenge for siRNA based therapeutics. Here, we report the development of new poly(glycoamidoamine) brush nanomaterials for efficient siRNA delivery. GluN4C10 polymer brush nanoparticles, a lead material, demonstrated significantly improved delivery efficiency for siRNA against factor VII (FVII) in mice compared to poly(glycoamidoamine) brush nanomaterials reported previously.
authors.affiliation: Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA. dong.525@osu.edu.
authors.forename: X
authors.initials: X
authors.lastname: Luo
authors.affiliation: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. dgander@mit.edu and Department of Anesthesiology, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: W
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
authors.forename: J R
authors.initials: JR
authors.lastname: Dorkin
authors.affiliation: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. dgander@mit.edu and Department of Anesthesiology, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA and Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
authors.forename: O
authors.initials: O
authors.lastname: Veiseh
authors.affiliation: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. dgander@mit.edu and Department of Anesthesiology, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: P H
authors.initials: PH
authors.lastname: Chang
authors.affiliation: Department of Biotechnology and Food Engineering, Technion Institute of Technology and the Russell Berrie Nanotechnology Institute, Haifa 32000, Israel.
authors.forename: I
authors.initials: I
authors.lastname: Abutbul-Ionita
authors.affiliation: Department of Biotechnology and Food Engineering, Technion Institute of Technology and the Russell Berrie Nanotechnology Institute, Haifa 32000, Israel.
authors.forename: D
authors.initials: D
authors.lastname: Danino
authors.affiliation: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. dgander@mit.edu and Department of Anesthesiology, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA and Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA and Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
authors.forename: R
authors.initials: R
authors.lastname: Langer
authors.affiliation: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. dgander@mit.edu and Department of Anesthesiology, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA and Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA and Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
authors.forename: D G
authors.initials: DG
authors.lastname: Anderson
authors.affiliation: Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA. dong.525@osu.edu and Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, USA and The Center for Clinical and Translational Science, The Ohio State University, Columbus, OH 43210, USA and The Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Dong
mesh_terms: D000588:Amines / Q000737:chemistry*; D000818:Animals; D051379:Mice; D049329:Nanostructures / Q000008:administration & dosage / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D034741:RNA, Small Interfering / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D000588:Amines; D011108:Polymers; D034741:RNA, Small Interfering