title: Hepatoprotective Effect of Tricholoma giganteum (Agaricomycetes) in a Nonalcoholic Fatty Liver Disease Rat Model.
abstract: Different concentrations of standardized ethanolic extract from the basidiocarps of Tricholoma giganteum Massee (TgEtOH) were screened for hepatoprotective effects in an animal model of rats with nonalcoholic fatty liver disease (NAFLD) fed a high-fat and high-fructose diet. After 4 weeks of treatment with TgEtOH, the relative liver weights, serum lipid concentrations, and biochemical profiles were found to be normal in treated animals compared with those given a standard drug. The macroscopic and histopathological studies clearly indicated that 200 mg/kg of ethanolic extract was effective in ameliorating the abnormalities of NAFLD. The findings indicate the efficacy of T. giganteum extract in liver protection. Future experiments on bioassay tailored fractionation of TgEtOH and mechanistic-based evaluation are required to assess the potential application of this mushroom as a food supplement in NAFLD.
authors.affiliation: Division of Ethnopharmacology, Entomology Research Institute, Loyola College, Nungambakkam, Chennai, Tamil Nadu, India.
authors.forename: Ramar
authors.initials: R
authors.lastname: Govindaraj
authors.affiliation: Division of Ethnopharmacology, Entomology Research Institute, Loyola College, Nungambakkam, Chennai, Tamil Nadu, India.
authors.forename: Michael Gabriel
authors.initials: MG
authors.lastname: Paulraj
authors.affiliation: Division of Ethnopharmacology, Entomology Research Institute, Loyola College, Nungambakkam, Chennai, Tamil Nadu, India.
authors.forename: Erenius
authors.initials: E
authors.lastname: Toppo
authors.affiliation: Division of Ethnopharmacology, Entomology Research Institute, Loyola College, Nungambakkam, Chennai, Tamil Nadu, India.
authors.forename: Perumal
authors.initials: P
authors.lastname: Pandikumar
authors.affiliation: Division of Ethnopharmacology, Entomology Research Institute, Loyola College, Nungambakkam, Chennai, Tamil Nadu, India; International Scientific Partnership, College of Science, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Savarimuthu
authors.initials: S
authors.lastname: Ignacimuthu
authors.affiliation: Department of Botany and Microbiology, College of Sciences, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Naif Abdhullah
authors.initials: NA
authors.lastname: Al-Dhabi
mesh_terms: D000818:Animals; D004040:Dietary Carbohydrates / Q000009:adverse effects*; D004041:Dietary Fats / Q000009:adverse effects*; D000431:Ethanol; D008297:Male; D065626:Non-alcoholic Fatty Liver Disease / Q000139:chemically induced / Q000517:prevention & control*; D020011:Protective Agents / Q000008:administration & dosage; D051381:Rats; D055439:Tricholoma / Q000737:chemistry*
chemical_list: D004040:Dietary Carbohydrates; D004041:Dietary Fats; D020011:Protective Agents; D000431:Ethanol