title: Severe gout: Strategies and innovations for effective management.
abstract: Severe gout is characterised by frequent polyarticular flares, numerous tophi, joint damage, and musculoskeletal disability. This is a preventable condition and in many cases, represents a disease that has been insufficiently managed for years. Standard management recommendations may be insufficient for patients with severe gout; these patients frequently require intensive individualised pharmacological management with combinations of urate-lowering therapy and anti-inflammatory agents. In this article, we aim to integrate recent therapeutic advances to provide a practical framework for optimal management of severe gout.
authors.affiliation: Sección de Reumatología, Hospital General Universitario de Alicante, Av. Pintor Baeza 12, 03010 Alicante, Spain; Departamento de Medicina Clínica (Reumatología), Universidad Miguel Hernández, Carretera Nacional 332 S/N, 03550, San Juan de Alicante, 03010 Alicante, Spain. Electronic address: pascual_eli@gva.es.
authors.forename: Eliseo
authors.initials: E
authors.lastname: Pascual
authors.affiliation: Sección de Reumatología, Hospital General Universitario de Alicante, Av. Pintor Baeza 12, 03010 Alicante, Spain; Departamento de Medicina Clínica (Reumatología), Universidad Miguel Hernández, Carretera Nacional 332 S/N, 03550, San Juan de Alicante, 03010 Alicante, Spain.
authors.forename: Mariano
authors.initials: M
authors.lastname: Andrés
authors.affiliation: Servicio de Reumatología, Hospital General de México, Dr. Balmis 148, Cuauhtémoc, Doctores, 06726 Ciudad de México, D.F., Mexico.
authors.forename: Janitzia
authors.initials: J
authors.lastname: Vázquez-Mellado
authors.affiliation: Department of Rheumatology, Auckland District Health Board and Department of Medicine, University of Auckland, Auckland 1010, New Zealand.
authors.forename: Nicola
authors.initials: N
authors.lastname: Dalbeth
mesh_terms: D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D015210:Arthritis, Gouty / Q000175:diagnosis / Q000188:drug therapy; D019468:Disease Management; D018450:Disease Progression; D004359:Drug Therapy, Combination; D005260:Female; D006073:Gout / Q000175:diagnosis* / Q000188:drug therapy*; D006074:Gout Suppressants / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D010147:Pain Measurement; D011379:Prognosis; D018570:Risk Assessment; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D006074:Gout Suppressants
keywords: Allopurinol; Colchicine; Febuxostat; Management; Refractory; Severe gout; Tophus