title: [Soft-tissue angiosarcoma with pulmonary metastases: case report and literature review].
abstract: Objective:To investigate the differential diagnosis between pulmonary metastases from soft-tissue angiosarcoma and primary pulmonary angiosarcoma.Methods:A case of soft-tissue angiosarcoma with pulmonary metastases was reported and related literatures were reviewed.Results:A 39 year-old man complaining of hemoptysis, cough, and sputum for 10 months was admitted to our hospital in September 2013. He was initially diagnosed as having primary pulmonary angiosarcoma after wedge-resection biopsy of the lung. After 22 months since onset, he felt discomfort in his leg, which led to the confirmative diagnosis of soft-tissue angiosarcoma of the leg with multiple pulmonary metastases by a full-body PET/CT scan and core needle biopsy of the leg. Twenty-three articles concerning primary pulmonary angiosarcoma with complete records of history, treatment and follow-up of patients were included in the literature review. A total of 26 patients were reported in these articles, including 18 males, 8 females, age 19-85 years, average (52±18) years. Primary pulmonary angiosarcoma was mainly manifested as single or multiple pulmonary nodules or masses, with or without ground glass opacity. In our case, chest CT showed multiple thin-wall cysts and ground glass opacities, and recurrent spontaneous pneumothorax, which had never been reported in literatures on primary pulmonary angiosarcoma.Conclusions:Pulmonary metastases from soft-tissue angiosarcoma differed from primary pulmonary lesions in terms of chest imaging, with the former usually showing thin-wall cysts and pneumothorax. A full-body PET-CT was essential for differential diagnosis between primary and metastatic pulmonary angiosarcoma.
authors.affiliation: *Department of Respiratory and Critical Care Medicine, Peking University People Hospital, Beijing 100044, China.
authors.forename: X L
authors.initials: XL
authors.lastname: Mu
authors.forename: Z X
authors.initials: ZX
authors.lastname: Wu
authors.forename: H J
authors.initials: HJ
authors.lastname: Liang
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
authors.forename: X
authors.initials: X
authors.lastname: Fang
authors.forename: D H
authors.initials: DH
authors.lastname: Yang
authors.forename: Z L
authors.initials: ZL
authors.lastname: Cao
authors.forename: Z C
authors.initials: ZC
authors.lastname: Gao
mesh_terms: D001706:Biopsy; D003937:Diagnosis, Differential; D006394:Hemangiosarcoma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000556:secondary; D006469:Hemoptysis / Q000209:etiology*; D006491:Hemothorax / Q000209:etiology; D006801:Humans; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary / Q000601:surgery; D008297:Male; D011030:Pneumothorax; D000072078:Positron Emission Tomography Computed Tomography; D012983:Soft Tissue Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000556:secondary; D014057:Tomography, X-Ray Computed / Q000379:methods*