title: Biological efficacy of two mineral trioxide aggregate (MTA)-based materials in a canine model of pulpotomy.
abstract: The aim of this study was to compare the biocompatibility of Endocem Zr®and ProRoot MTA®by histopathologic analysis in a canine model of pulpotomy. This study utilized 39 teeth of two beagle dogs. The exposed pulp tissues were treated by pulpotomy using ProRoot MTA (n=19) or Endocem Zr (n=20). After 8 weeks, the teeth were extracted and processed with hematoxylin-eosin staining for histologic evaluation. Most of the specimens in both groups developed a calcific barrier at the pulp amputation site and formed an odontoblast layer. However, some of the Endocem Zr specimens showed less calcific barrier formation with a greater inflammatory response and less odontoblast layer formation when compared with the ProRoot MTA specimens. ProRoot MTA and Endocem Zr specimens developed a calcific barrier; however, ProRoot MTA was more biocompatible than Endocem Zr.
authors.affiliation: Department of Pediatric Dentistry, College of Dentistry, Yonsei University.
authors.forename: Myeongyeon
authors.initials: M
authors.lastname: Lee
authors.forename: Chung-Min
authors.initials: CM
authors.lastname: Kang
authors.forename: Je Seon
authors.initials: JS
authors.lastname: Song
authors.forename: Yooseok
authors.initials: Y
authors.lastname: Shin
authors.forename: Seunghye
authors.initials: S
authors.lastname: Kim
authors.forename: Seong-Oh
authors.initials: SO
authors.lastname: Kim
authors.forename: Hyung-Jun
authors.initials: HJ
authors.lastname: Choi
mesh_terms: D017607:Aluminum Compounds; D000818:Animals; D017610:Calcium Compounds; D003782:Dental Pulp; D004285:Dogs; D004338:Drug Combinations; D009804:Odontoblasts; D010087:Oxides; D011672:Pulpotomy; D012387:Root Canal Filling Materials; D017640:Silicates; D014070:Tooth
chemical_list: D017607:Aluminum Compounds; D017610:Calcium Compounds; D004338:Drug Combinations; D010087:Oxides; D012387:Root Canal Filling Materials; D017640:Silicates; C086631:mineral trioxide aggregate