title: Long Noncoding RNA snaR Regulates Proliferation, Migration and Invasion of Triple-negative Breast Cancer Cells.
abstract: We evaluated the role of long noncoding ribonucleic acid (lncRNA) in breast cancer cell lines by quantitative reverse transcription-polymerase change reaction.
  
  
  
  The effects of small NF90-associated RNA (snaR) with RNA interference on proliferation, migration and invasion of MDA-MB-231 cells were observed by 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide, wound healing and transwell assay.
  
  
  
  Among 90 lncRNAs, E2F transcription factor 4, p107/p130-binding (E2F4) antisense, insulin-like growth factor 2 antisense (IGF2AS), snaR, and small nucleolar RNA host gene 5 (SNHG5) were up-regulated in MDA-MB-231 and 7SK, antisense noncoding RNA in the INK4 locus (ANRIL), IGF2AS, Nespas, p53 mRNA, and snaR were up-regulated in MCF-7 cells. Down-regulation of snaR inhibited the proliferation, migration, and invasion of MDA-MD-231 breast cancer cells.
  
  
  
  LncRNA snaR was found to be up-regulated in breast cancer cells, and the cancer progression of MDA-MB-231 cells was significantly suppressed by down-regulation of snaR. Therefore, snaR knockdown has potential as a treatment modality for triple-negative breast cancer.
authors.affiliation: Department of Surgery, Kyungpook National University School of Medicine, Daegu, Republic of Korea.
authors.forename: Jeeyeon
authors.initials: J
authors.lastname: Lee
authors.affiliation: Department of Surgery, Kyungpook National University School of Medicine, Daegu, Republic of Korea jjh01@knu.ac.kr yschae@knu.ac.kr.
authors.forename: Jin Hyang
authors.initials: JH
authors.lastname: Jung
authors.affiliation: Department of Hemato-Oncology, Kyungpook National University School of Medicine, Daegu, Republic of Korea jjh01@knu.ac.kr yschae@knu.ac.kr.
authors.forename: Yee Soo
authors.initials: YS
authors.lastname: Chae
authors.affiliation: Department of Surgery, Kyungpook National University School of Medicine, Daegu, Republic of Korea.
authors.forename: Ho Yong
authors.initials: HY
authors.lastname: Park
authors.affiliation: Department of Surgery, Kyungpook National University School of Medicine, Daegu, Republic of Korea.
authors.forename: Wan Wook
authors.initials: WW
authors.lastname: Kim
authors.affiliation: Department of Hemato-Oncology, Kyungpook National University School of Medicine, Daegu, Republic of Korea.
authors.forename: Soo Jung
authors.initials: SJ
authors.lastname: Lee
authors.affiliation: Department of Cell and Matrix Research Institute, Kyungpook National University School of Medicine, Daegu, Republic of Korea.
authors.forename: Jae-Hwan
authors.initials: JH
authors.lastname: Jeong
authors.affiliation: Department of Cell and Matrix Research Institute, Kyungpook National University School of Medicine, Daegu, Republic of Korea.
authors.forename: Seung Hee
authors.initials: SH
authors.lastname: Kang
mesh_terms: D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000235:genetics*; D005260:Female; D055785:Gene Knockdown Techniques; D006801:Humans; D009361:Neoplasm Invasiveness / Q000235:genetics*; D009362:Neoplasm Metastasis / Q000235:genetics*; D062085:RNA, Long Noncoding / Q000502:physiology*; D064726:Triple Negative Breast Neoplasms / Q000235:genetics / Q000473:pathology*
chemical_list: D062085:RNA, Long Noncoding
keywords: Long noncoding RNA; breast cancer; progression; triple-negative