title: [Increased serum levels of soluble programmed death-1 (sPD-1) and sPD-ligand 1 in patients infected with Brucella].
abstract: Objective To investigate the alterations of soluble molecule programmed death 1 (sPD-1) and soluble programmed death ligand 1 (sPD-L1), as well as related Th1 cytokines IFN-γ and Th2 cytokines IL-4 in patients infected with Brucella. Methods The study enrolled 56 patients infected with Brucella and 48 healthy controls. Serum sPD-1 and sPD-L1 were detected by ELISA and the levels of Th1/Th2 cytokines were measured with cytometric bead array (CBA). Among them, 37 patients received follow-up. Results Compared with the control group, the serum levels of sPD-1/sPD-L1 and IL-4 increased significantly, while the level of IFN-γ decreased significantly. In the 37 patients receiving follow-up after treatment, serum levels of sPD-1/sPD-L1 and IL-4 were remarkably lower than those in pretherapy, while the level of IFN-γ was obviously higher than that in pretherapy. Conclusion The increase of sPD-1 and sPD-L1 may be involved in the process of Brucella infection.
authors.affiliation: Department of Immunology, School of Preclinieal Medicine, Xinjiang Medical University, Urumqi 830011, China.
authors.forename: Pan
authors.initials: P
authors.lastname: Pang
authors.affiliation: Department of Clinical Laboratory, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China.
authors.forename: Yuejie
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Department of Clinical Laboratory, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Jia
authors.affiliation: Department of Clinical Laboratory, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Clinical Laboratory, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China.
authors.forename: Jinwei
authors.initials: J
authors.lastname: Hu
authors.affiliation: Department of Clinical Laboratory, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China.
authors.forename: Yuexin
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Clinical Laboratory, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China. *Corresponding authors, E-mail:765219598@qq.com.
authors.forename: Fengbo
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Department of Immunology, School of Preclinieal Medicine, Xinjiang Medical University, Urumqi 830011; Department of Clinical Laboratory, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China. *Corresponding authors, E-mail: djbing002@sina.com.
authors.forename: Jianbing
authors.initials: J
authors.lastname: Ding
mesh_terms: D000328:Adult; D060890:B7-H1 Antigen / Q000097:blood*; D002002:Brucella / Q000472:pathogenicity*; D002006:Brucellosis / Q000097:blood*; D016207:Cytokines / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007371:Interferon-gamma; D015847:Interleukin-4 / Q000097:blood; D008297:Male; D061026:Programmed Cell Death 1 Receptor / Q000097:blood*; D018417:Th1 Cells / Q000378:metabolism; D018418:Th2 Cells / Q000378:metabolism; D055815:Young Adult
chemical_list: D060890:B7-H1 Antigen; C423236:CD274 protein, human; D016207:Cytokines; C573415:IFNG protein, human; C105992:PDCD1 protein, human; D061026:Programmed Cell Death 1 Receptor; D015847:Interleukin-4; D007371:Interferon-gamma