title: Generalized epilepsy syndromes and callosal thickness: Differential effects between patients with juvenile myoclonic epilepsy and those with generalized tonic-clonic seizures alone.
abstract: The definition of two well-studied genetic generalized epilepsy syndromes (GGE) - juvenile myoclonic epilepsy (JME) and epilepsy with generalized tonic-clonic seizures alone (GTCS) - suggests the absence of structural cerebral abnormalities. Nevertheless, there are various reports of such abnormalities (especially in JME), where effects mainly occur within thalamus and mesial prefrontal regions. This raises the question of whether JME is particularly linked to midline structure abnormalities, which may also involve the corpus callosum.
  
  
  
  We studied callosal morphology in a well-matched sample of 22 JME patients, 15 GTCS patients, and 42 controls (CTL) for all of whom we obtained T1-weighted data on a 3T MRI scanner. More specifically, we measured callosal thickness at 100 equidistant points across the callosal surface, and subsequently compared the three groups (JME, GTCS, and CTL) against each other.
  
  
  
  Significant differences between JME patients and controls were observed within the callosal genu, anterior midbody, and isthmus, with thinner regions in JME patients. There were no significant differences between GTCS patients and controls, and also not between JME patients and GTCS patients.
  
  
  
  The present outcomes point to callosal abnormalities in JME patients suggesting an impairment of interhemisperic communication between prefrontal, motor, parietal and temporal cortices. These findings further support the notion that structural aberrations are present and differentiated across GGE syndromes, with significant callosal deviations from normality in JME.
authors.affiliation: Karolinska University Hospital, Neuropediatrics, Stockholm, Sweden.
authors.forename: Stavroula
authors.initials: S
authors.lastname: Anastasopoulou
authors.affiliation: Department of Neurology, UCLA School of Medicine, Los Angeles, CA, USA; Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, CA, USA.
authors.forename: Florian
authors.initials: F
authors.lastname: Kurth
authors.affiliation: Department of Neurology, UCLA School of Medicine, Los Angeles, CA, USA; Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, CA, USA.
authors.forename: Eileen
authors.initials: E
authors.lastname: Luders
authors.affiliation: Karolinska Institute and Karolinska Hospital and Neurology Clinic, Karolinska University Hospital Stockholm, Sweden. Electronic address: ivanka.savic-berglund@ki.se.
authors.forename: Ivanka
authors.initials: I
authors.lastname: Savic
mesh_terms: D000328:Adult; D003337:Corpus Callosum / Q000000981:diagnostic imaging*; D004830:Epilepsy, Tonic-Clonic / Q000000981:diagnostic imaging* / Q000188:drug therapy; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D020190:Myoclonic Epilepsy, Juvenile / Q000000981:diagnostic imaging* / Q000188:drug therapy; D009929:Organ Size
keywords: Corpus callosum; Generalized tonic-clonic seizures; Juvenile myoclonic epilepsy