title: Effect of moderate and high intensity chronic exercise on the pancreatic islet morphometry in healthy rats: BDNF receptor participation.
abstract: The function and morphology of β-cells is largely dependent on insulin demand. As β-cells cover a bigger cell proportion in pancreas islets, changes of insulin producer cells affect the whole pancreatic islet morphology. Growth factors as the neurotrophins regulate the pancreas physiology, besides; physical exercise increases insulin sensitivity, and further modifies brain derived neurotrophic factor (BDNF) concentration in plasma. The aim of this study was to investigate the effects of chronic exercise (running in a treadmill for 8 weeks) intensity on pancreatic islet morphometry in healthy state. The BDNF receptor effect on the pancreatic islet morphometry was also evaluated. Adult male Wistar rats were divided in 6 groups: Control (C); moderate intensity training (MIT); high intensity training (HIT) did not treat with BDNF receptor inhibitor (K252a), and C, MIT and HIT treated with K252a. The results shown that chronic exercise induces β-cells hypertrophy without BDNF receptor participation. On the other hand, the moderate exercise increases the number of β cells per islet; the last effect does not require TrkB participation. In sedentary conditions, the K252a treatment reduced the β-cell density. Exercise intensity has differential effects on pancreas islet morphometry in healthy model; furthermore, BDNF receptor plays a role to maintain the amount of β-cells in sedentary state.
authors.affiliation: a Centro Universitario de Investigaciones Biomédicas, Universidad de Colima , Colima , México.
authors.forename: Alberto
authors.initials: A
authors.lastname: Jiménez-Maldonado
authors.affiliation: a Centro Universitario de Investigaciones Biomédicas, Universidad de Colima , Colima , México.
authors.forename: Adolfo
authors.initials: A
authors.lastname: Virgen-Ortiz
authors.affiliation: b Facultad de Medicina, Universidad de Colima , Colima , México.
authors.forename: Valery
authors.initials: V
authors.lastname: Melnikov
authors.affiliation: b Facultad de Medicina, Universidad de Colima , Colima , México.
authors.forename: Alejandrina
authors.initials: A
authors.lastname: Rodríguez-Hernández
authors.affiliation: c Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán ," Tlalpan , México.
authors.forename: Armando
authors.initials: A
authors.lastname: Gamboa-Domínguez
authors.affiliation: a Centro Universitario de Investigaciones Biomédicas, Universidad de Colima , Colima , México.|b Facultad de Medicina, Universidad de Colima , Colima , México.
authors.forename: Sergio
authors.initials: S
authors.lastname: Montero
authors.affiliation: a Centro Universitario de Investigaciones Biomédicas, Universidad de Colima , Colima , México.
authors.forename: Jesús
authors.initials: J
authors.lastname: Muñiz-Murguía
authors.affiliation: a Centro Universitario de Investigaciones Biomédicas, Universidad de Colima , Colima , México.
authors.forename: Mónica
authors.initials: M
authors.lastname: Lemus
authors.affiliation: a Centro Universitario de Investigaciones Biomédicas, Universidad de Colima , Colima , México.
authors.forename: Elena
authors.initials: E
authors.lastname: Roces de Álvarez-Buylla
mesh_terms: D000818:Animals; D048430:Cell Shape / Q000502:physiology; D050417:Insulin-Secreting Cells / Q000166:cytology* / Q000378:metabolism; D007515:Islets of Langerhans / Q000166:cytology* / Q000378:metabolism; D008297:Male; D010805:Physical Conditioning, Animal / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D020813:Receptor, trkB / Q000378:metabolism*
chemical_list: D020813:Receptor, trkB
keywords: BDNF receptor; exercise; islets; β-cells