title: Antioxidant, antibacterial and anti-aging activities of intracellular zinc polysaccharides from Grifola frondosa SH-05.
abstract: In present work, the strain of Grifola frondosa SH-05 was used as a vector of zinc biotransformation to produce the IZPS. The bioactivities including antioxidant and antibacterial activities in vitro and anti-aging properties in vivo of IZPS were investigated comparing with the IPS. The results which were in consistent with the results of histopathology assay demonstrated that the IZPS had superior antioxidant and anti-aging activities by scavenging the hydroxyl and DPPH radicals, increasing enzyme activities, decreasing the MDA contents and ameliorating the anile condition of mice. Besides, the IZPS also showed potential antibacterial activities. The IZPS with higher bioactivities was composed of were Rha, Ino and Glu with a molar ratio of 4.7:3.6:1. These conclusions indicated that the IZPS might be a potential source of natural antioxidant, antibacterial agent and anti-aging agent.
authors.affiliation: Institute of Plant and Environment Protection, Beijing Academy of Agriculture and Forestry Sciences, Beijing Engineering Research Center for Edible Mushroom, Key Laboratory of Urban Agriculture (North), Ministry of Agriculture, Beijing, PR China; College of Life Science, Shandong Agricultural University, Taian 271018, PR China.
authors.forename: Chen
authors.initials: C
authors.lastname: Zhang
authors.affiliation: College of Life Science, Shandong Agricultural University, Taian 271018, PR China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Gao
authors.affiliation: College of Forestry, Shandong Agricultural University, Taian 271018, PR China.
authors.forename: Chunlong
authors.initials: C
authors.lastname: Hu
authors.affiliation: College of Life Science, Shandong Agricultural University, Taian 271018, PR China.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Zhang
authors.affiliation: College of Life Science, Shandong Agricultural University, Taian 271018, PR China.
authors.forename: Xinyi
authors.initials: X
authors.lastname: Sun
authors.affiliation: Institute of Plant and Environment Protection, Beijing Academy of Agriculture and Forestry Sciences, Beijing Engineering Research Center for Edible Mushroom, Key Laboratory of Urban Agriculture (North), Ministry of Agriculture, Beijing, PR China. Electronic address: woshiboer@163.com.
authors.forename: Chengbo
authors.initials: C
authors.lastname: Rong
authors.affiliation: College of Life Science, Shandong Agricultural University, Taian 271018, PR China. Electronic address: jiale0525@163.com.
authors.forename: Le
authors.initials: L
authors.lastname: Jia
mesh_terms: D000375:Aging / Q000187:drug effects*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000494:pharmacology*; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D018533:Biomass; D001711:Biotransformation; D001921:Brain / Q000166:cytology / Q000187:drug effects; D048691:Grifola / Q000737:chemistry*; D042541:Intracellular Space / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D009005:Monosaccharides / Q000032:analysis; D011134:Polysaccharides / Q000096:biosynthesis / Q000494:pharmacology*; D015032:Zinc / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D000975:Antioxidants; D009005:Monosaccharides; D011134:Polysaccharides; D015032:Zinc
keywords: Antibacterial activities; Antioxidant and anti-aging activities; Grifola frondosa SH-05; Histopathology assay; Intracellular zinc polysaccharides