title: Safety profile of 1,25-dihydroxyvitamin D3 of herbal origin in broiler chicken.
abstract: The safety of supplementing broiler feed with a standardised herbal extract, Solanum Glaucophyllum Standardised Leaves (SGSL) containing glycosylated 1a,25-dihydroxyvitamin D3 (1,25(OH)2D3) and standardised to contain 10 µg/g 1,25(OH)2D3 equivalent, was examined in two studies. In a first study, we examined the potential of SGSL to substitute vitamin D3 (VD3) and the tolerated dose range of SGSL when applied without concomitant VD3 by analyzing performance and blood chemical parameters after 14, 25 and 38 days on diets containing two doses of SGSL (1 and 10 g/kg feed) as source of 1,25(OH)2D3. In the second study, the no adverse effect level of SGSL was determined by analyzing the same parameters after 35 days on diets containing basic VD3 supply and in addition 0.2, 1.0, 2.0 and 4.0 g of SGSL/kg feed. We showed that SGSL was able to substitute VD3 in broilers as far as the performance parameters were concerned. Also, we found that the no adverse effect level is at least 4 g SGSL/kg feed when used with moderate doses of VD3. This is 20 times higher than the upper limit of the commercially recommended dose. We concluded that SGSL is a safe feed additive to use in broiler chicken.
authors.affiliation: Appletree CI Group AG, Winterthur, Switzerland.
authors.forename: G
authors.initials: G
authors.lastname: Mathis
authors.affiliation: INBIOSUR-CO, Universidad Nacional del Sur, Departamento de Biología, Bioquímica y Farmacia, Bahia Blanca, Argentina.
authors.forename: R
authors.initials: R
authors.lastname: Boland
authors.affiliation: Herbonis AG, Basel, Switzerland.
authors.forename: H
authors.initials: H
authors.lastname: Bachmann
authors.affiliation: Appletree CI Group AG, Winterthur, Switzerland.
authors.forename: A
authors.initials: A
authors.lastname: Toggenburger
authors.affiliation: Institut für Tierernährung, Ludwig-Maximilians-Universität München, Oberschleissheim, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Rambeck
mesh_terms: D000821:Animal Feed; D000818:Animals; D002117:Calcitriol / Q000008:administration & dosage / Q000097:blood / Q000592:standards*; D002645:Chickens / Q000097:blood; D005527:Food, Fortified / Q000592:standards*; D010936:Plant Extracts / Q000008:administration & dosage / Q000097:blood / Q000592:standards*; D012449:Safety; D036061:Solanum glaucophyllum / Q000737:chemistry*
chemical_list: D010936:Plant Extracts; D002117:Calcitriol
keywords: 1,25-Dihydroxyvitamin D3-Glycoside; 1,25-Dihydroxyvitamin D3-glycosides; Futtersicherheit; Masthühner; Solanum glaucophyllum; Vitamin D; broiler; feed safety