title: Multi-Biomarker Responses After Exposure to Pollution in the Mediterranean Mussels (Mytilus galloprovincialis L.) in the Aegean Coast of Turkey.
abstract: In this study, sublethal effects on the Mediterranean mussels (Mytilus galloprovincialis L.) collected from the Aegean coast of Turkey were determined. Enzymes such as glutathione-S-transferase (GST), superoxide dismutase (SOD), catalase (CAT), and acetylcholinesterase (AChE), metallothionein (MT) mRNA expressions, thiobarbituric acid reactive substances (TBARS) contents, determination of 14 heavy metals and micronucleus frequency were selected as multibiomarkers. Results show that heavy metals and an increase in the level of MT gene expression have been determined in tissues of mussels collected from all stations. The GST, SOD and CAT enzymes were increased in mussels of Aliaga and Old Foca, compared to the mussels of Urla, while it was showed inhibition at AChE levels. Extensive LP is determined on mussels of Aliaga. It was determined that mussels in Aliaga region have exposed more oxidative stress than Old Foca and Urla. These biomarkers were carried out for the first time in these stations to assess environmental quality.
authors.affiliation: Faculty of Science, Department of Biology, Ege University, 35100, Bornova-Izmir, Turkey.
authors.forename: Dilara
authors.initials: D
authors.lastname: Ozkan
authors.affiliation: Faculty of Science, Department of Biology, Ege University, 35100, Bornova-Izmir, Turkey.|Center for Drug Research & Development and Pharmacokinetic Applications, Ege University, 35100, Bornova-Izmir, Turkey.
authors.forename: Melih
authors.initials: M
authors.lastname: Dagdeviren
authors.affiliation: Faculty of Science and Art, Department of Biology, Celal Bayar University, Muradiye-Manisa, Turkey.
authors.forename: Selma
authors.initials: S
authors.lastname: Katalay
authors.affiliation: Faculty of Science, Department of Biology, Ege University, 35100, Bornova-Izmir, Turkey.
authors.forename: Adem
authors.initials: A
authors.lastname: Guner
authors.affiliation: Faculty of Science, Department of Biology, Ege University, 35100, Bornova-Izmir, Turkey. ulku.karabay@ege.edu.tr.|Center for Drug Research & Development and Pharmacokinetic Applications, Ege University, 35100, Bornova-Izmir, Turkey. ulku.karabay@ege.edu.tr.
authors.forename: N Ülkü Karabay
authors.initials: NÜ
authors.lastname: Yavaşoğlu
mesh_terms: D000110:Acetylcholinesterase / Q000235:genetics / Q000378:metabolism; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D002374:Catalase / Q000235:genetics / Q000378:metabolism; D004784:Environmental Monitoring / Q000379:methods*; D005786:Gene Expression Regulation; D005819:Genetic Markers; D005982:Glutathione Transferase / Q000235:genetics / Q000378:metabolism; D008668:Metallothionein / Q000235:genetics / Q000378:metabolism; D019216:Metals, Heavy / Q000032:analysis; D049878:Mytilus / Q000187:drug effects* / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D013482:Superoxide Dismutase / Q000235:genetics / Q000378:metabolism; D014421:Turkey; D014874:Water Pollutants, Chemical / Q000032:analysis*
chemical_list: D015415:Biomarkers; D005819:Genetic Markers; D019216:Metals, Heavy; D014874:Water Pollutants, Chemical; D008668:Metallothionein; D002374:Catalase; D013482:Superoxide Dismutase; D005982:Glutathione Transferase; D000110:Acetylcholinesterase
keywords: Heavy metal; Metallothionein; Mytilus galloprovincialis L.; Oxidative stress; RT-PCR