title: Recurrent Cytogenetic Abnormalities in Acute Lymphoblastic Leukemia.
abstract: Both B-cell and T-cell acute lymphoblastic leukemia (ALL) exhibit recurrent cytogenetic alterations, many with prognostic implications. This chapter overviews the major recurrent categories of cytogenetic abnormalities associated with ALL, with an emphasis on the detection and characterization of these cases by G-band and FISH analyses.
authors.affiliation: Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada, M5G 1X8. mary.shago@sickkids.ca.|Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada, M5S 1A1. mary.shago@sickkids.ca.
authors.forename: Mary
authors.initials: M
authors.lastname: Shago
mesh_terms: D002869:Chromosome Aberrations; D005784:Gene Amplification; D015321:Gene Rearrangement; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D007621:Karyotyping; D015514:Oncogene Proteins, Fusion / Q000235:genetics; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis* / Q000235:genetics* / Q000401:mortality; D011379:Prognosis; D014178:Translocation, Genetic
chemical_list: D015514:Oncogene Proteins, Fusion
keywords: Acute lymphoblastic leukemia; Chromosome abnormalities; Cytogenetics; Fluorescence in situ hybridization (FISH)