title: Advances in Lipidomics for Cancer Biomarkers Discovery.
abstract: Lipids play critical functions in cellular survival, proliferation, interaction and death, since they are involved in chemical-energy storage, cellular signaling, cell membranes, and cell-cell interactions. These cellular processes are strongly related to carcinogenesis pathways, particularly to transformation, progression, and metastasis, suggesting the bioactive lipids are mediators of a number of oncogenic processes. The current review gives a synopsis of a lipidomic approach in tumor characterization; we provide an overview on potential lipid biomarkers in the oncology field and on the principal lipidomic methodologies applied. The novel lipidomic biomarkers are reviewed in an effort to underline their role in diagnosis, in prognostic characterization and in prediction of therapeutic outcomes. A lipidomic investigation through mass spectrometry highlights new insights on molecular mechanisms underlying cancer disease. This new understanding will promote clinical applications in drug discovery and personalized therapy.
authors.affiliation: Department of Neurosciences and Imaging, University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy. francescaperrotti@libero.it.|Radiation Oncology Unit, SS Annunziata Hospital, 66100 Chieti, Italy. francescaperrotti@libero.it.
authors.forename: Francesca
authors.initials: F
authors.lastname: Perrotti
authors.affiliation: Department of Neurosciences and Imaging, University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy. c.rosa155@gmail.com.|Radiation Oncology Unit, SS Annunziata Hospital, 66100 Chieti, Italy. c.rosa155@gmail.com.
authors.forename: Consuelo
authors.initials: C
authors.lastname: Rosa
authors.affiliation: Department of Pharmacy, University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy. ilariacicalini1@gmail.com.|Department of Medical Oral and Biotechnological Sciences, University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy. ilariacicalini1@gmail.com.|Analitical Biochemistry and Proteomics Unit, Research Centre on Aging (Ce.S.I), University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy. ilariacicalini1@gmail.com.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Cicalini
authors.affiliation: Department of Medical Oral and Biotechnological Sciences, University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy. ps@unich.it.|Analitical Biochemistry and Proteomics Unit, Research Centre on Aging (Ce.S.I), University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy. ps@unich.it.
authors.forename: Paolo
authors.initials: P
authors.lastname: Sacchetta
authors.affiliation: Department of Pharmacy, University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy. p.delboccio@unich.it.|Department of Medical Oral and Biotechnological Sciences, University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy. p.delboccio@unich.it.|Analitical Biochemistry and Proteomics Unit, Research Centre on Aging (Ce.S.I), University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy. p.delboccio@unich.it.
authors.forename: Piero
authors.initials: P
authors.lastname: Del Boccio
authors.affiliation: Department of Neurosciences and Imaging, University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy. d.genovesi@unich.it.|Radiation Oncology Unit, SS Annunziata Hospital, 66100 Chieti, Italy. d.genovesi@unich.it.
authors.forename: Domenico
authors.initials: D
authors.lastname: Genovesi
authors.affiliation: Department of Medical Oral and Biotechnological Sciences, University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy. dpieragostino@unich.it.|Analitical Biochemistry and Proteomics Unit, Research Centre on Aging (Ce.S.I), University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy. dpieragostino@unich.it.
authors.forename: Damiana
authors.initials: D
authors.lastname: Pieragostino
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D006801:Humans; D050356:Lipid Metabolism / Q000502:physiology; D008055:Lipids / Q000502:physiology*; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D008055:Lipids
keywords: biomarkers; cancer; diagnostic factors; lipidomics; prognostic factors