title: N-Terminal pro-B-Type Natriuretic Peptide Levels are Linked with Modified Child-Pugh Classification in Patients with Nonalcoholic Cirrhosis [NT-ProBNP and Liver Cirrhosis].
abstract: Excess N-terminal pro-brain natriuretic peptide secretion has been linked to cirrhosis in previously studies. The relationship of plasma N-terminal pro-brain natriuretic peptide levels and cardiac dysfunction determined by echocardiography were investigated in patients with nonalcoholic cirrhosis and a control group of chronic hepatitis. This study was designed as a cross-sectional study. Thirty-two men and thirty-three women who gave informed consent who were followed-up for chronic liver failure were enrolled. All patients gave clinical history, physical examination was carried out and information about ongoing medication has been obtained. Serum N-terminal pro-brain natriuretic peptide level was measured in all patients. The same cardiologist determined ejection fraction, end-diastolic left ventricular diameter, interventricular septum, and posterior wall on transthoracic echocardiography. Patients with extensive liver disease according to Child-Pugh classification from A to C had increasing N-terminal pro-brain natriuretic peptide levels in association (P < .001). According to the Child-Pugh classification there were no significant difference between groups for echocardiographic measurements (P > .05). N-terminal pro-brain natriuretic peptide may be an important marker for cardiac dysfunction in patients with chronic liver failure in accordance with Child-Pugh stage.
authors.affiliation: Clinic of Internal Medicine, Haseki Education and Research Hospital, Istanbul, Turkey.
authors.forename: Abdulbaki
authors.initials: A
authors.lastname: Kumbasar
authors.affiliation: Clinic of Internal Medicine, Haseki Education and Research Hospital, Istanbul, Turkey.
authors.forename: Mehtap
authors.initials: M
authors.lastname: Navdar
authors.affiliation: Clinic of Internal Medicine, Haseki Education and Research Hospital, Istanbul, Turkey.
authors.forename: Esra
authors.initials: E
authors.lastname: Ataoglu
authors.affiliation: Department of Cardiology, Istanbul University Institute of Cardiology, Istanbul, Turkey.
authors.forename: Isil
authors.initials: I
authors.lastname: Uzunhasan
authors.affiliation: Clinic of Internal Medicine, Haseki Education and Research Hospital, Istanbul, Turkey.
authors.forename: Kadir
authors.initials: K
authors.lastname: Ergen
authors.affiliation: Department of Gastroenterohepatology, Haseki Education and Research Hospital, Istanbul, Turkey.
authors.forename: Sule
authors.initials: S
authors.lastname: Poturoglu
authors.affiliation: Clinic of Biochemistry, Haseki Education and Research Hospital, Istanbul, Turkey.
authors.forename: Filiz
authors.initials: F
authors.lastname: Basinoglu
authors.affiliation: Clinic of Internal Medicine, Haseki Education and Research Hospital, Istanbul, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Yilmaz
authors.affiliation: Clinic of Internal Medicine, Haseki Education and Research Hospital, Istanbul, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Yenigun
authors.affiliation: Clinic of Internal Medicine, Haseki Education and Research Hospital, Istanbul, Turkey.
authors.forename: Fuat
authors.initials: F
authors.lastname: Sar
authors.affiliation: Department of Internal Medicine, Trakya University Faculty of Medicine, Edirne, Turkey. mugla.medicaloncology@gmail.com.
authors.forename: Ozgur
authors.initials: O
authors.lastname: Tanriverdi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006331:Heart Diseases / Q000097:blood; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood* / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D015415:Biomarkers; D020097:Natriuretic Peptide, Brain
keywords: Cardiac dysfunction; Cirrhosis; N-terminale pro-B-type natriuretic peptide