title: Yinzhihuang oral liquid in the treatment of neonatal jaundice: a meta-analysis.
abstract: BACKGROUND
  Yinzhihuang oral liquid, a well-known Chinese herbal formula, is a clinical drug for the treatment of neonatal jaundice, and a number of clinical trials have been published addressing this issue, but there is no comprehensive analysis that evaluates its efficacy for the treatment of newborn with hyperbilirubinaemia.
  
  
  OBJECTIVE
  A meta-analysis was conducted to evaluate the efficacy of Yinzhihuang oral liquid on neonatal jaundice.
  
  
  METHODS
  Search was performed throughout PubMed, Cochrane Library, EMBASE, Ovid, Wanfang, VIP Medicine Information System (VMIS) and China National Knowledge Infrastructure (CNKI) databases up to December 2015. The search terms were (Yinzhihuang oral liquid or Yinzhihuang oral solution), (neonatal jaundice or neonatal hyperbilirubinaemia), and (efficacy). Review Manager 5.2 software was used for analyzing the data. Data were pooled by using the random-effects models and expressed as relative ratio (RR), standardized mean difference (SMD) or mean difference (MD) with a 95% confidence interval (CI). The Cochrane tool was applied to assess the risk of bias of the trials.
  
  
  RESULTS
  Yinzhihuang oral liquid in conjunction with other therapy increased effective rate of neonatal jaundice therapy (RR =1.14, 95%CI: 1.08-1.20). Yinzhihuang oral liquid significantly eliminated overproduced bilirubin which was measured by TSB or TCB at the third day and fifth day during the treatment {[third day, SMD = -1.63, 95%CI: -2.20 to (-1.06)], [fifth day, SMD = -5.00, 95%CI: -7.88 to (-2.12)]}; Yinzhihuang oral liquid significantly shortened jaundice subsiding time [MD = -3.20, 95%CI: -6.01to (-0.39)].
  
  
  CONCLUSIONS
  Yinzhihuang oral liquid can be considered as an effective treatment option for neonatal jaundice.
authors.affiliation: a Department of Pharmacy , The Fifth Affiliated Hospital of Guangzhou Medical University , Guangzhou , China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zeng
authors.affiliation: b Department of Clinical Pharmacy , Guangdong Pharmaceutical University , Guangzhou , China.
authors.forename: Su-Jun
authors.initials: SJ
authors.lastname: Wang
authors.affiliation: a Department of Pharmacy , The Fifth Affiliated Hospital of Guangzhou Medical University , Guangzhou , China.
authors.forename: Yong-Mei
authors.initials: YM
authors.lastname: Li
authors.affiliation: a Department of Pharmacy , The Fifth Affiliated Hospital of Guangzhou Medical University , Guangzhou , China.
authors.forename: Hang-Shan
authors.initials: HS
authors.lastname: Li
authors.affiliation: a Department of Pharmacy , The Fifth Affiliated Hospital of Guangzhou Medical University , Guangzhou , China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Luo
authors.affiliation: a Department of Pharmacy , The Fifth Affiliated Hospital of Guangzhou Medical University , Guangzhou , China.
authors.forename: Yun-Ying
authors.initials: YY
authors.lastname: Huang
authors.affiliation: a Department of Pharmacy , The Fifth Affiliated Hospital of Guangzhou Medical University , Guangzhou , China.
authors.forename: Qun
authors.initials: Q
authors.lastname: Jiang
authors.affiliation: a Department of Pharmacy , The Fifth Affiliated Hospital of Guangzhou Medical University , Guangzhou , China.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
mesh_terms: D001663:Bilirubin / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D016009:Chi-Square Distribution; D004365:Drugs, Chinese Herbal / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D051556:Hyperbilirubinemia, Neonatal / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D007231:Infant, Newborn; D016017:Odds Ratio; D008517:Phytotherapy; D010946:Plants, Medicinal; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D004365:Drugs, Chinese Herbal; C070600:yin zhi huang; D001663:Bilirubin
keywords: Yinzhihuang oral liquid; meta-analysis; neonatal jaundice