title: Effect of Day and Night Desflurane Anaesthesia on Melatonin Levels in Rats.
abstract: OBJECTIVE
  The aim of this study is to investigate the effect of day and night administration of desflurane anaesthesia on melatonin levels in rats.
  
  
  METHODS
  Twenty-four 15-day-old rats were included in the study and were divided into four groups. The rats were anaesthetised between 19:00-01:00 (night group) and 07:00-13:00 (day group) with 5.7% desflurane concentration in 6 L min-1100% oxygen. 6 L min-1oxygen was administered to the control groups. At the end of 6 h of anaesthesia, blood samples were taken, and rats were sacrificed. Blood samples were centrifuged and melatonin levels from plasma samples were measured with radioimmunoassay.
  
  
  RESULTS
  There was a statistically significant difference between the groups (p=0.007). Between group day control and group night control there was a statistically significant difference (p=0.042). Further, there was a significant difference between group day control and night desfluran as well (p=0.024). We could not find any difference between other groups.
  
  
  CONCLUSIONS
  This study showed that 6 hours of 5.7% desflurane anaesthesia during day and night hours did not significantly change melatonin levels.
authors.affiliation: Department of Anaesthesiology and Reanimation, Dokuz Eylül University School of Medicine, İzmir, Turkey.
authors.forename: Figen Datlı
authors.initials: FD
authors.lastname: Özer
authors.affiliation: Department of Anaesthesiology and Reanimation, Dokuz Eylül University School of Medicine, İzmir, Turkey.
authors.forename: Elvan
authors.initials: E
authors.lastname: Öçmen
authors.affiliation: Department of Biochemistry, Dokuz Eylül University School of Medicine, İzmir, Turkey.
authors.forename: Pınar
authors.initials: P
authors.lastname: Akan
authors.affiliation: Department of Anaesthesiology and Reanimation, Dokuz Eylül University School of Medicine, İzmir, Turkey.
authors.forename: Hale Aksu
authors.initials: HA
authors.lastname: Erdost
authors.affiliation: Department of Anaesthesiology and Reanimation, Dokuz Eylül University School of Medicine, İzmir, Turkey.
authors.forename: Sezen
authors.initials: S
authors.lastname: Korkut
authors.affiliation: Department of Anaesthesiology and Reanimation, Dokuz Eylül University School of Medicine, İzmir, Turkey.
authors.forename: Ali Necati
authors.initials: AN
authors.lastname: Gökmen
keywords: Melatonin; desflurane; rats