title: Adhesion and Invasion of Gastric Mucosa Epithelial Cells byHelicobacter pylori.
abstract: Helicobacter pyloriis the main pathogenic bacterium involved in chronic gastritis and peptic ulcer and a class 1 carcinogen in gastric cancer. Current research focuses on the pathogenicity ofH. pyloriand the mechanism by which it colonizes the gastric mucosa. An increasing number ofin vivoandin vitrostudies demonstrate thatH. pylorican invade and proliferate in epithelial cells, suggesting that this process might play an important role in disease induction, immune escape and chronic infection. Therefore, to explore the process and mechanism of adhesion and invasion of gastric mucosa epithelial cells byH. pyloriis particularly important. This review examines the relevant studies and describes evidence regarding the adhesion to and invasion of gastric mucosa epithelial cells byH. pylori.
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital of Nanchang University Nanchang, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Department of General Surgery, Tianjin Haihe Hospital Tianjin, China.
authors.forename: Qi-Long
authors.initials: QL
authors.lastname: Wang
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital of Nanchang University Nanchang, China.
authors.forename: Dan-Dan
authors.initials: DD
authors.lastname: Cheng
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital of Nanchang University Nanchang, China.
authors.forename: Wen-Ting
authors.initials: WT
authors.lastname: Xu
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital of Nanchang University Nanchang, China.
authors.forename: Nong-Hua
authors.initials: NH
authors.lastname: Lu
mesh_terms: D000818:Animals; D001422:Bacterial Adhesion; D004847:Epithelial Cells / Q000382:microbiology*; D005753:Gastric Mucosa / Q000382:microbiology*; D016480:Helicobacter pylori / Q000502:physiology*; D006801:Humans
keywords: Helicobacter pylori; adhesion; chronic infection; invasion; mechanism