title: Impact of enriched environment on production of tau, amyloid precursor protein and, amyloid-β peptide in high-fat and high-sucrose-fed rats.
abstract: OBJECTIVE
  The Western-type diet is associated with an elevated risk of Alzheimer's disease and other milder forms of cognitive impairment. The aim of the present study was to investigate the effects of the environmental enrichment on amyloid and tau pathology in high-fat and high-sucrose-fed rats.
  
  
  METHODS
  In total, 40 adult male rats were categorised into two main groups according to their housing conditions: enriched environment (EE, n=16) and standard housing condition (n=24). The groups were further divided into five subgroups that received standard diet, high-fat diet, and high-sucrose diet. We performed the analysis of amyloid β-peptide (Aβ) (1-40), Aβ(1-42), amyloid precursor protein (APP), and tau levels in the hippocampus of rats that were maintained under standard housing conditions or exposed to an EE.
  
  
  RESULTS
  The EE decreased the Aβ(1-40), Aβ(1-42), APP, and tau levels in high-fat and high-sucrose-fed rats.
  
  
  CONCLUSIONS
  This observation shows that EE may rescue diet-induced amyloid and tau pathology.
authors.affiliation: 1Department of Psychiatry,Neuroscience Research Center (SAM) Konya, Selcuk University Medicine Faculty,Konya,Turkey.
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Selvi
authors.affiliation: 1Department of Psychiatry,Neuroscience Research Center (SAM) Konya, Selcuk University Medicine Faculty,Konya,Turkey.
authors.forename: Hasan Serdar
authors.initials: HS
authors.lastname: Gergerlioglu
authors.affiliation: 2Department of Psychiatry, Selcuk University Medicine Faculty,Konya,Turkey.
authors.forename: Nursel
authors.initials: N
authors.lastname: Akbaba
authors.affiliation: 3Department of Physiology, Bozok University Medicine Faculty,Yozgat,Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Oz
authors.affiliation: 2Department of Psychiatry, Selcuk University Medicine Faculty,Konya,Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Kandeger
authors.affiliation: 4Department of Physiology, Mustafa Kemal University Medicine Faculty,Hatay,Turkey.
authors.forename: Enver Ahmet
authors.initials: EA
authors.lastname: Demir
authors.affiliation: 5Department of Biochemistry, Necmettin Erbakan University Medicine Faculty,Konya,Turkey.
authors.forename: Fatma Humeyra
authors.initials: FH
authors.lastname: Yerlikaya
authors.affiliation: 6Department of Pharmacology, Necmettin Erbakan University Medicine Faculty,Konya,Turkey.
authors.forename: Kismet Esra
authors.initials: KE
authors.lastname: Nurullahoglu-Atalik
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000378:metabolism; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism*; D000818:Animals; D059305:Diet, High-Fat / Q000009:adverse effects*; D000073417:Dietary Sugars / Q000009:adverse effects*; D004777:Environment; D006624:Hippocampus / Q000378:metabolism; D008297:Male; D010446:Peptide Fragments / Q000378:metabolism; D017208:Rats, Wistar; D016875:tau Proteins / Q000378:metabolism*
chemical_list: D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D000073417:Dietary Sugars; C489131:Mapt protein, rat; D010446:Peptide Fragments; C078592:amyloid beta-protein (1-40); C075222:amyloid beta-protein (1-42); D016875:tau Proteins
keywords: Alzheimer’s disease; amyloid; diet; hippocampus; tau