title: Mitochondrial fission and fusion.
abstract: Mitochondrial fission and fusion have been recognized as critical processes in the health of mitochondria and cells. Two decades of studies have generated a great deal of information about mitochondrial fission and fusion; however, still much needs to be understood for the basic molecular mechanisms of these important cellular processes. The core protein factors for mitochondrial fission and fusion are dynamin proteins that possess membrane-remodeling properties. This short review covers a recent development and understanding of the mechanisms by which these mechanochemical enzymes mediate mitochondrial fission and fusion.
authors.affiliation: Department of Physiology, Medical College of Georgia, Augusta University, 1120 Fifteenth Street, Augusta, GA 30912, U.S.A.
authors.forename: Hakjoo
authors.initials: H
authors.lastname: Lee
authors.affiliation: Department of Physiology, Medical College of Georgia, Augusta University, 1120 Fifteenth Street, Augusta, GA 30912, U.S.A.
authors.forename: Yisang
authors.initials: Y
authors.lastname: Yoon
mesh_terms: D000818:Animals; D034281:Dynamins / Q000378:metabolism; D006160:Guanosine Triphosphate / Q000378:metabolism; D006801:Humans; D008561:Membrane Fusion; D008928:Mitochondria / Q000378:metabolism*; D063154:Mitochondrial Dynamics; D051336:Mitochondrial Membranes / Q000378:metabolism*; D024101:Mitochondrial Proteins / Q000378:metabolism; D008954:Models, Biological
chemical_list: D024101:Mitochondrial Proteins; D006160:Guanosine Triphosphate; D034281:Dynamins
keywords: dynamin; mitochondria; mitochondrial dynamics