title: Poor muscle strength and function in physically inactive childhood-onset systemic lupus erythematosus despite very mild disease.
abstract: To compare muscle strength (i.e. lower- and upper-body strength) and function between physically inactive childhood-onset systemic lupus erythematosus patients (C-SLE) and healthy controls (CTRL).
  
  
  
  This was a cross-sectional study and the sample consisted of 19 C-SLE (age between 9 and 18 years) and 15 CTRL matched by age, sex, body mass index (BMI), and physical activity levels (assessed by accelerometry). Lower- and upper-body strength was assessed by the one-repetition-maximum (1-RM) test. Isometric strength was assessed through a handgrip dynamometer. Muscle function was evaluated by the timed-stands test (TST) and the timed-up-and-go test (TUG).
  
  
  
  When compared with CTRL, C-SLE showed lower leg-press and bench-press 1-RM (p=0.026 and p=0.008, respectively), and a tendency toward lower handgrip strength (p=0.052). C-SLE showed lower TST scores (p=0.036) and a tendency toward higher TUG scores (p=0.070) when compared with CTRL.
  
  
  
  Physically inactive C-SLE patients with very mild disease showed reduced muscle strength and functionality when compared with healthy controls matched by physical activity levels. These findings suggest C-SLE patients may greatly suffer from a physically inactive lifestyle than healthy controls do. Moreover, some sub-clinical "residual" effect of the disease or its pharmacological treatment seems to affect C-SLE patients even with a well-controlled disease.
authors.affiliation: Universidade de São Paulo (USP), Grupo de Pesquisa em Fisiologia Aplicada e Nutrição, São Paulo, SP, Brazil.
authors.forename: Ana Jéssica
authors.initials: AJ
authors.lastname: Pinto
authors.affiliation: Universidade de São Paulo (USP), Faculdade de Medicina, Divisão de Reumatologia, São Paulo, SP, Brazil.
authors.forename: Fabiana Braga
authors.initials: FB
authors.lastname: Benatti
authors.affiliation: Universidade de São Paulo (USP), Grupo de Pesquisa em Fisiologia Aplicada e Nutrição, São Paulo, SP, Brazil; Universidade de São Paulo (USP), Faculdade de Medicina, Divisão de Reumatologia, São Paulo, SP, Brazil.
authors.forename: Hamilton
authors.initials: H
authors.lastname: Roschel
authors.affiliation: Universidade de São Paulo (USP), Faculdade de Medicina, Divisão de Reumatologia, São Paulo, SP, Brazil.
authors.forename: Ana Lúcia
authors.initials: AL
authors.lastname: de Sá Pinto
authors.affiliation: Universidade de São Paulo (USP), Faculdade de Medicina, Instituto da Criança, São Paulo, SP, Brazil.
authors.forename: Clovis Artur
authors.initials: CA
authors.lastname: Silva
authors.affiliation: Universidade de São Paulo (USP), Faculdade de Medicina, Instituto da Criança, São Paulo, SP, Brazil.
authors.forename: Adriana Maluf Elias
authors.initials: AM
authors.lastname: Sallum
authors.affiliation: Universidade de São Paulo (USP), Grupo de Pesquisa em Fisiologia Aplicada e Nutrição, São Paulo, SP, Brazil; Universidade de São Paulo (USP), Faculdade de Medicina, Divisão de Reumatologia, São Paulo, SP, Brazil. Electronic address: gualano@usp.br.
authors.forename: Bruno
authors.initials: B
authors.lastname: Gualano
mesh_terms: D000293:Adolescent; D015992:Body Mass Index; D016022:Case-Control Studies; D002648:Child; D003430:Cross-Sectional Studies; D015444:Exercise / Q000502:physiology*; D005260:Female; D018737:Hand Strength / Q000502:physiology*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000503:physiopathology*; D008297:Male; D009043:Motor Activity; D053580:Muscle Strength / Q000502:physiology*
keywords: Capacidade funcional; Doença reumática; Força muscular; Muscle function; Nível de atividade física; Physical activity level; Rheumatic disease; Strength