title: First report of tumor treating fields use in combination with bevacizumab in a pediatric patient: a case report.
abstract: We report the first case of a pediatric patient with glioblastoma (GBM; WHO grade IV astrocytoma) successfully treated with tumor treating fields (TTF). The patient was diagnosed with GBM when 13 years of age and progressed through surgical resection, radiotherapy and chemotherapy. Discrete tumor growth visualized on MRI with stable neurological examination was monitored for 6 months with subsequent stable disease observed radiographically and clinically for 7 months while adherent to Optune®(TTF). TTF thereby played a role in forestalling recurrent GBM growth in this young woman for 7 months without significant adverse effects. We propose that TTF therapy is a potential valuable treatment in this small, but sick, patient population.
authors.affiliation: Department of Neurology, University of California, IrvineOr Medical Center, Orange, CA, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: O'Connell
authors.affiliation: Department of Neurology, University of California, IrvineOr Medical Center, Orange, CA, USA.
authors.forename: Violet
authors.initials: V
authors.lastname: Shen
authors.affiliation: Department of Neurology, University of California, IrvineOr Medical Center, Orange, CA, USA.
authors.forename: William
authors.initials: W
authors.lastname: Loudon
authors.affiliation: Department of Neurology, University of California, IrvineOr Medical Center, Orange, CA, USA.
authors.forename: Daniela A
authors.initials: DA
authors.lastname: Bota
mesh_terms: D000293:Adolescent; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D000068258:Bevacizumab / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000235:genetics / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D005909:Glioblastoma / Q000000981:diagnostic imaging / Q000235:genetics / Q000628:therapy*; D006801:Humans; D055909:Magnetic Field Therapy / Q000379:methods*; D008279:Magnetic Resonance Imaging; D016896:Treatment Outcome
chemical_list: D020533:Angiogenesis Inhibitors; D000068258:Bevacizumab
keywords: CNS neoplasm; astrocytoma; bevacizumab; cisplatin; glioblastoma; glioma; pediatric; recurrence; temozolomide; tumor treating fields