title: Synergistic Effect of Lipoprotein-Associated Phospholipase A2 with Classical Risk Factors on Coronary Heart Disease: A Multi-Ethnic Study in China.
abstract: OBJECTIVE
  We evaluated the synergistic effect of lipoprotein-associated phospholipase A2 (Lp-PLA2) in association with classical risk factors in predicting coronary heart disease (CHD) and demonstrated the diagnostic value of Lp-PLA2 for predicting coronary stenotic lesions in subjects with CHD.
  
  
  METHODS
  Blood samples were acquired from 911 consecutive adult subjects (662 males and 249 females) from 11 ethnic groups. Lp-PLA2 plasma levels were detected using a commercially available turbidimetric immunoassay (TIA). CHD in patients was confirmed using coronary angiography, and the severity of coronary atherosclerosis was assessed using the Gensini scoring system.
  
  
  RESULTS
  A binary logistic regression was performed to analyse the relationships between Lp-PLA2 and other risk factors. A multivariate logistic regression analysis revealed that Lp-PLA2 levels were significantly associated with CHD (OR, 1.882; 95% CI, 1.369-2.587, p=0.000).The area under the receiver operating characteristic curve for Lp-PLA2 was 0.589 (95%CI, 0.549-0.629, p=0.000).The synergism between Lp-PLA2 and other risk factors was also investigated. The proportion of CHD attributable to the interaction between Lp-PLA2 and age was as high as 64%.
  
  
  CONCLUSIONS
  Lp-PLA2 levels in human plasma were positively associated with the severity of CHD, and there was a clear positive interaction between Lp-PLA2 and classical risk factors in predicting CHD.
authors.affiliation: Department of Cardiovascular Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
authors.forename: Peng-Cheng
authors.initials: PC
authors.lastname: Ge
authors.forename: Zhao-Hong
authors.initials: ZH
authors.lastname: Chen
authors.forename: Ren-You
authors.initials: RY
authors.lastname: Pan
authors.forename: Xiao-Qing
authors.initials: XQ
authors.lastname: Ding
authors.forename: Jie-Yin
authors.initials: JY
authors.lastname: Liu
authors.forename: Qiao-Wei
authors.initials: QW
authors.lastname: Jia
authors.forename: Zhe
authors.initials: Z
authors.lastname: Liu
authors.forename: Shi-Zhao
authors.initials: SZ
authors.lastname: He
authors.forename: Feng-Hui
authors.initials: FH
authors.lastname: An
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Li
authors.forename: Zhao-Yang
authors.initials: ZY
authors.lastname: Li
authors.forename: Yan
authors.initials: Y
authors.lastname: Gu
authors.forename: Tie-Bing
authors.initials: TB
authors.lastname: Zhu
authors.forename: Chun-Jian
authors.initials: CJ
authors.lastname: Li
authors.forename: Lian-Sheng
authors.initials: LS
authors.lastname: Wang
authors.forename: Wen-Zhu
authors.initials: WZ
authors.lastname: Ma
authors.forename: Zhi-Jian
authors.initials: ZJ
authors.lastname: Yang
authors.forename: En-Zhi
authors.initials: EZ
authors.lastname: Jia
mesh_terms: D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase / Q000378:metabolism*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002681:China; D003327:Coronary Disease / Q000201:enzymology*; D003710:Demography; D005006:Ethnicity; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012372:ROC Curve; D012307:Risk Factors; D018709:Statistics, Nonparametric
chemical_list: D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase