title: Biological Molecules for the Regeneration of the Pulp-Dentin Complex.
abstract: Regenerative endodontic treatment has yielded excellent clinical outcomes, but only several animal studies have shown the robust regeneration of the pulp-dentin complex. The biological molecules, if properly delivered, can enkindle regeneration of dental pulp and dentin rather than repair with tissues of periodontal origin. This review details the biological significance of regenerating the pulp-dentin complex, the effects of biological cues in pulp regeneration, and the delivery strategies of biological molecules to enhance the outcomes of regenerative endodontic therapy.
authors.affiliation: Division of Endodontics, College of Dental Medicine, Columbia University, 630 West 168 Street, PH7Stem128, New York, NY 10032, USA. Electronic address: sgk2114@columbia.edu.
authors.forename: Sahng G
authors.initials: SG
authors.lastname: Kim
mesh_terms: D000818:Animals; D001685:Biological Factors / Q000008:administration & dosage / Q000627:therapeutic use*; D003782:Dental Pulp / Q000502:physiology*; D003804:Dentin / Q000502:physiology*; D006801:Humans; D012038:Regeneration
chemical_list: D001685:Biological Factors
keywords: Biological cues; Biological molecules; Growth factors; Odontoblast; Pulp-dentin complex; Signaling molecules; Tubular dentin