title: Severe acute respiratory infection caused by swine influenza virus in a child necessitating extracorporeal membrane oxygenation (ECMO), the Netherlands, October 2016.
abstract: In October 2016, a severe infection with swine influenza A(H1N1) virus of the Eurasian avian lineage occurred in a child with a previous history of eczema in the Netherlands, following contact to pigs. The patient's condition deteriorated rapidly and required life support through extracorporeal membrane oxygenation. After start of oseltamivir treatment and removal of mucus plugs, the patient fully recovered. Monitoring of more than 80 close unprotected contacts revealed no secondary cases.
authors.affiliation: Department of Viroscience Erasmus MC, Rotterdam, The Netherlands.|Department of Pediatrics, Subdivision Infectious diseases and Immunology, Erasmus MC - Sophia, Rotterdam, The Netherlands.
authors.forename: Pieter L A
authors.initials: PL
authors.lastname: Fraaij
authors.affiliation: Intensive Care and Department of Pediatric Surgery, Erasmus MC-Sophia, Rotterdam, The Netherlands.
authors.forename: Enno D
authors.initials: ED
authors.lastname: Wildschut
authors.affiliation: Intensive Care and Department of Pediatric Surgery, Erasmus MC-Sophia, Rotterdam, The Netherlands.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Houmes
authors.affiliation: Centre for Infectious Disease Control-National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
authors.forename: Corien M
authors.initials: CM
authors.lastname: Swaan
authors.affiliation: Department of Sexual Health, Infectious Diseases and Environmental Health, Public Health Service South Limburg, Geleen, The Netherlands.|Faculty of Health, Medicine and Life Sciences Department of Medical Microbiology, Maastricht Infection Center (MINC),School of Public Health and Primary Care (CAPHRI),Maastricht University Medical Center (MUMC+), Maastricht, The Netherlands.
authors.forename: Christian J
authors.initials: CJ
authors.lastname: Hoebe
authors.affiliation: Gemeentelijke Gezondheidsdienst Rotterdam-Rijnmond, Rotterdam, The Netherlands.
authors.forename: H C C
authors.initials: HC
authors.lastname: de Jonge
authors.affiliation: Gemeentelijke Gezondheidsdienst Brabant zuidoost, Eindhoven, The Netherlands.
authors.forename: Paulien
authors.initials: P
authors.lastname: Tolsma
authors.affiliation: Department of Paediatrics, Subdivision of pulmonary medicine, Erasmus MC - Sophia, Rotterdam, The Netherlands.
authors.forename: Isme
authors.initials: I
authors.lastname: de Kleer
authors.affiliation: Department of Viroscience Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Suzan D
authors.initials: SD
authors.lastname: Pas
authors.affiliation: Department of Viroscience Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Bas B
authors.initials: BB
authors.lastname: Oude Munnink
authors.affiliation: Department of Viroscience Erasmus MC, Rotterdam, The Netherlands.
authors.forename: My V T
authors.initials: MV
authors.lastname: Phan
authors.affiliation: Department of Viroscience Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Theo M
authors.initials: TM
authors.lastname: Bestebroer
authors.affiliation: Department of Viroscience Erasmus MC, Rotterdam, The Netherlands.
authors.forename: R Shanty
authors.initials: RS
authors.lastname: Roosenhoff
authors.affiliation: Department of Viroscience Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Jeroen J A
authors.initials: JJ
authors.lastname: van Kampen
authors.affiliation: Department of Viroscience Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Matthew
authors.initials: M
authors.lastname: Cotten
authors.affiliation: Wageningen Bioveterinary reseach- Wageningen University and Research, Lelystad, the Netherlands.
authors.forename: Nancy
authors.initials: N
authors.lastname: Beerens
authors.affiliation: Department of Viroscience Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Ron A M
authors.initials: RA
authors.lastname: Fouchier
authors.affiliation: Centre for Infectious Disease Control-National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
authors.forename: Johannes H
authors.initials: JH
authors.lastname: van den Kerkhof
authors.affiliation: Centre for Infectious Disease Control-National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
authors.forename: Aura
authors.initials: A
authors.lastname: Timen
authors.affiliation: Department of Viroscience Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Marion P
authors.initials: MP
authors.lastname: Koopmans
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use; D015199:Extracorporeal Membrane Oxygenation; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000302:isolation & purification*; D007251:Influenza, Human / Q000175:diagnosis* / Q000188:drug therapy / Q000821:virology; D015278:Intensive Care Units, Pediatric; D009426:Netherlands; D009976:Orthomyxoviridae Infections / Q000635:transmission / Q000662:veterinary / Q000821:virology; D053139:Oseltamivir / Q000627:therapeutic use; D060888:Real-Time Polymerase Chain Reaction; D012141:Respiratory Tract Infections / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D045169:Severe Acute Respiratory Syndrome / Q000150:complications / Q000628:therapy*; D013552:Swine; D013553:Swine Diseases / Q000635:transmission / Q000821:virology; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D053139:Oseltamivir
keywords: Children; ECMO; Influenza; Severe; Swine