title: Novel Chlorinated Polyfluorinated Ether Sulfonates and Legacy Per-/Polyfluoroalkyl Substances: Placental Transfer and Relationship with Serum Albumin and Glomerular Filtration Rate.
abstract: Per- and polyfluoroalkyl substances (PFASs) may cross the placental barrier and lead to fetal exposure. However, little is known about the factors that influence maternal-fetal transfer of these chemicals. PFAS concentrations were analyzed in 100 paired samples of human maternal sera collected in each trimester and cord sera at delivery; these samples were collected in Wuhan, China, 2014. Linear regression was used to estimate associations of transfer efficiencies with factors. Chlorinated polyfluorinated ether sulfonates (Cl-PFAESs, 6:2 and 8:2) were frequently detected (>99%) in maternal and cord sera. A significant decline in PFAS levels during the three trimesters was observed. A U-shape trend for transfer efficiency with increasing chain length was observed for both carboxylates and sulfonates. Higher transfer efficiencies of PFASs were associated with advancing maternal age, higher education, and lower glomerular filtration rate (GFR). Cord serum albumin was a positive factors for higher transfer efficiency (increased 1.1-4.1% per 1g/L albumin), whereas maternal serum albumin tended to reduce transfer efficiency (decreased 2.4-4.3% per 1g/L albumin). Our results suggest that exposure to Cl-PFAESs may be widespread in China. The transfer efficiencies among different PFASs were structure-dependent. Physiological factors (e.g., GFR and serum albumin) were observed for the first time to play critical roles in PFAS placental transfer.
authors.affiliation: Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences , Beijing 100101, P. R. China.
authors.forename: Yitao
authors.initials: Y
authors.lastname: Pan
authors.affiliation: Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, Hubei, P. R. China.
authors.forename: Yingshuang
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Department of Epidemiology, School of Public Health, Brown University , Providence, Rhode Island 02912, United States.
authors.forename: Tongzhang
authors.initials: T
authors.lastname: Zheng
authors.affiliation: Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences , Beijing 100101, P. R. China.
authors.forename: Qianqian
authors.initials: Q
authors.lastname: Cui
authors.affiliation: Department of Epidemiology, School of Public Health, Brown University , Providence, Rhode Island 02912, United States.
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Buka
authors.affiliation: Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, Hubei, P. R. China.|Women and Children Medical and Healthcare Center of Wuhan , Wuhan 430030, Hubei, P. R. China.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , Shanghai 200032, P. R. China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, Hubei, P. R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Xia
authors.affiliation: Man-Technology-Environment Research Centre (MTM), School of Science and Technology, Örebro University , SE-70182, Örebro, Sweden.
authors.forename: Leo W Y
authors.initials: LW
authors.lastname: Yeung
authors.affiliation: Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, Hubei, P. R. China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Women and Children Medical and Healthcare Center of Wuhan , Wuhan 430030, Hubei, P. R. China.
authors.forename: Aifen
authors.initials: A
authors.lastname: Zhou
authors.affiliation: Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, Hubei, P. R. China.|Women and Children Medical and Healthcare Center of Wuhan , Wuhan 430030, Hubei, P. R. China.
authors.forename: Lin
authors.initials: L
authors.lastname: Qiu
authors.affiliation: Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, Hubei, P. R. China.
authors.forename: Hongxiu
authors.initials: H
authors.lastname: Liu
authors.affiliation: Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, Hubei, P. R. China.
authors.forename: Minmin
authors.initials: M
authors.lastname: Jiang
authors.affiliation: Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, Hubei, P. R. China.
authors.forename: Chuansha
authors.initials: C
authors.lastname: Wu
authors.affiliation: Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, Hubei, P. R. China.
authors.forename: Shunqing
authors.initials: S
authors.lastname: Xu
authors.affiliation: Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences , Beijing 100101, P. R. China.
authors.forename: Jiayin
authors.identifier: 0000-0003-4908-5597
authors.initials: J
authors.lastname: Dai
mesh_terms: D002681:China; D004986:Ether; D004987:Ethers; D005260:Female; D005466:Fluorocarbons; D005919:Glomerular Filtration Rate; D006801:Humans; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D012709:Serum Albumin
chemical_list: D004987:Ethers; D005466:Fluorocarbons; D012709:Serum Albumin; D004986:Ether