title: [The correlation between cerebral MRI characteristics of posterior reversible encephalopathy syndrome and serum levels of PlGF, sEng in patients with pre-eclampsia].
abstract: Objective:To investigate the MRI characteristics of posterior reversible encephalopathy syndrome (PRES) in patients with pre-eclampsia(PE) and its correlation with serum placental growth factor (PlGF), soluble endoglin (sEng) and sEng/PlGF ratio.Methods:34 patients with PE who were admitted to Guangdong Women and Children Hospital from September 2013 to March 2014 were studied retrospectively.13 cases had PRES and 21 cases had normal cerebral MRI. All patients underwent conventional MRI and DWI scanning. The score of brain edema (SBE) were calculated. PlGF, sEng concentrations were measured with ELISA. The levels of PlGF, sEng and sEng/PlGF were compared between the PRES group and the normal MRI groups. The correlation of sEng/PIGF ratio and SBE were studied as well.Results:The PlGF in the PRSE group was (231.4±66.8) ng/L, and in normal cerebral MRI group was (333.6±37.5) ng/L (t=5.61,P<0.05). The sEng in the PRSE group was (5 256.2±879.6) ng/L, in normal cerebral MRI group was (3 955.6±537.7) ng/L (t=6.53,P<0.01).The sEng/PlGF in the PRSE group was (26.0±10.0) , and in normal cerebral MRI group was (11.9±1.6;t=8.41,P<0.01) , with the cut-off value of 20.0. The sensitivity was 81.8% and the specificity was 85.0%.There was no statistically significant correlation between PlGF, sEng and SBE (P>0.05).There was a positive correlation between the sEng/PlGF ratio and SBE (P>0.05).Conclusion:The value of sEng/PlGF ratio was correlated with brain edema score in PE. The serum sEng/PlGF ratio may be used as a reference for prediction of PRES.
authors.affiliation: Department of Radiology, Guangdong Women and Children Hospital, Guangzhou 511400, China.
authors.forename: K M
authors.initials: KM
authors.lastname: Jiang
authors.forename: X
authors.initials: X
authors.lastname: Zhong
authors.forename: Y
authors.initials: Y
authors.lastname: Tan
authors.forename: G C
authors.initials: GC
authors.lastname: Liu
authors.forename: H
authors.initials: H
authors.lastname: Mai
authors.forename: S X
authors.initials: SX
authors.lastname: Wu
mesh_terms: D000328:Adult; D015703:Antigens, CD; D015415:Biomarkers / Q000097:blood; D001929:Brain Edema; D000071063:Endoglin / Q000097:blood*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D010920:Placenta / Q000378:metabolism*; D000072483:Placenta Growth Factor / Q000097:blood* / Q000378:metabolism; D054038:Posterior Leukoencephalopathy Syndrome / Q000000981:diagnostic imaging*; D011225:Pre-Eclampsia / Q000378:metabolism*; D011247:Pregnancy; D011257:Pregnancy Proteins; D011956:Receptors, Cell Surface; D012189:Retrospective Studies; D015398:Signal Transduction
chemical_list: D015703:Antigens, CD; D015415:Biomarkers; C064206:ENG protein, human; D000071063:Endoglin; C000608036:PGF protein, human; D011257:Pregnancy Proteins; D011956:Receptors, Cell Surface; D000072483:Placenta Growth Factor