title: Effects of Melatonin, Aluminum Oxide, and Polymethylsiloxane Complex on the Expression of LYVE-1 in the Liver of Mice with Obesity and Type 2 Diabetes Mellitus.
abstract: The effects of melatonin, aluminum oxide, and polymethylsiloxane complex on the expression of LYVE-1 (lymphatic vessel endothelial hyaluronan receptor) in the liver were studied in db/db mice with experimental obesity and type 2 diabetes mellitus. The complex or placebo was administered daily by gavage from week 8 to week 16 of life. The animals receiving the complex exhibited enhanced, in comparison with the placebo group, immunohistochemical LYVE-1+ staining of endothelial cells in sinusoids. Enhanced expression of LYVE-1 was associated with less pronounced dilatation of interlobular arteries, veins, and lymphatic vessels. Thee findings suggest a protective effect of the complex towards structural changes in the liver of mice with obesity and type 2 diabetes.
authors.affiliation: Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia. s.michurina@ngs.ru.|Federal Research Center, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia. s.michurina@ngs.ru.
authors.forename: S V
authors.initials: SV
authors.lastname: Michurina
authors.affiliation: Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia.|Federal Research Center, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
authors.forename: I Yu
authors.initials: IY
authors.lastname: Ishchenko
authors.affiliation: Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia.|Federal Research Center, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
authors.forename: S A
authors.initials: SA
authors.lastname: Arkhipov
authors.affiliation: Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia.|Federal Research Center, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Klimontov
authors.affiliation: Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia.|Federal Research Center, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
authors.forename: L N
authors.initials: LN
authors.lastname: Rachkovskaya
authors.affiliation: Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia.|Federal Research Center, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
authors.forename: V I
authors.initials: VI
authors.lastname: Konenkov
authors.affiliation: Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia.|Federal Research Center, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
authors.forename: E L
authors.initials: EL
authors.lastname: Zavyalov
mesh_terms: D000537:Aluminum Oxide / Q000737:chemistry; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001786:Blood Glucose / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D004195:Disease Models, Animal; D042783:Endothelial Cells / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D005260:Female; D015870:Gene Expression / Q000187:drug effects; D006023:Glycoproteins / Q000819:agonists* / Q000235:genetics / Q000378:metabolism; D006499:Hepatic Artery / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D006720:Homozygote; D006943:Hyperglycemia / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D042601:Lymphatic Vessels / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008550:Melatonin / Q000494:pharmacology*; D026901:Membrane Transport Proteins; D051379:Mice; D008822:Mice, Transgenic; D009765:Obesity / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D054411:Receptors, Leptin / Q000172:deficiency / Q000235:genetics; D012828:Silicones / Q000737:chemistry
chemical_list: D000537:Aluminum Oxide; D000975:Antioxidants; D001786:Blood Glucose; D006023:Glycoproteins; D008550:Melatonin; D026901:Membrane Transport Proteins; D054411:Receptors, Leptin; D012828:Silicones; C492273:LYVE1 protein, mouse; C515447:leptin receptor, mouse; C078211:polymethylsiloxane
keywords: LYVE-1; liver; melatonin; sinusoidal cells; type 2 diabetes mellitus