title: Magnetic resonance imaging and immunohistochemistry of primary vertebral hemangiosarcoma in a dog and implications for diagnosis and therapy.
abstract: A vertebral mass in a dog with an acute onset paraparesis was identified by magnetic resonance imaging. A poorly differentiated hemangiosarcoma was diagnosed by histopathology and immunohistochemistry. Endothelial nitric oxide synthase could be a new differential marker for poorly differentiated hemangiosarcoma in dogs. Immunohistochemical detection of p53 phosphorylated at Serine392, p53, CD117, and CD44 suggest targets for design of therapeutic strategies.
authors.affiliation: Institute of Biomedicine (IBIOMED) (Pérez-Martínez, García-Iglesias), Department of Veterinary Medicine, Surgery and Anatomy, Veterinary School (Regueiro-Purriños, Altónaga, Gonzalo-Orden), University of León, Spain; Micros Veterinaria, León, Spain (Fernández-Martínez).
authors.forename: Claudia
authors.initials: C
authors.lastname: Pérez-Martínez
authors.affiliation: Institute of Biomedicine (IBIOMED) (Pérez-Martínez, García-Iglesias), Department of Veterinary Medicine, Surgery and Anatomy, Veterinary School (Regueiro-Purriños, Altónaga, Gonzalo-Orden), University of León, Spain; Micros Veterinaria, León, Spain (Fernández-Martínez).
authors.forename: Marta
authors.initials: M
authors.lastname: Regueiro-Purriños
authors.affiliation: Institute of Biomedicine (IBIOMED) (Pérez-Martínez, García-Iglesias), Department of Veterinary Medicine, Surgery and Anatomy, Veterinary School (Regueiro-Purriños, Altónaga, Gonzalo-Orden), University of León, Spain; Micros Veterinaria, León, Spain (Fernández-Martínez).
authors.forename: Beatriz
authors.initials: B
authors.lastname: Fernández-Martínez
authors.affiliation: Institute of Biomedicine (IBIOMED) (Pérez-Martínez, García-Iglesias), Department of Veterinary Medicine, Surgery and Anatomy, Veterinary School (Regueiro-Purriños, Altónaga, Gonzalo-Orden), University of León, Spain; Micros Veterinaria, León, Spain (Fernández-Martínez).
authors.forename: José R
authors.initials: JR
authors.lastname: Altónaga
authors.affiliation: Institute of Biomedicine (IBIOMED) (Pérez-Martínez, García-Iglesias), Department of Veterinary Medicine, Surgery and Anatomy, Veterinary School (Regueiro-Purriños, Altónaga, Gonzalo-Orden), University of León, Spain; Micros Veterinaria, León, Spain (Fernández-Martínez).
authors.forename: José M
authors.initials: JM
authors.lastname: Gonzalo-Orden
authors.affiliation: Institute of Biomedicine (IBIOMED) (Pérez-Martínez, García-Iglesias), Department of Veterinary Medicine, Surgery and Anatomy, Veterinary School (Regueiro-Purriños, Altónaga, Gonzalo-Orden), University of León, Spain; Micros Veterinaria, León, Spain (Fernández-Martínez).
authors.forename: María J
authors.initials: MJ
authors.lastname: García-Iglesias
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000000981:diagnostic imaging* / Q000473:pathology; D004285:Dogs; D006394:Hemangiosarcoma / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D007150:Immunohistochemistry / Q000662:veterinary; D008159:Lumbar Vertebrae / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000662:veterinary*; D008297:Male; D013125:Spinal Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*