title: Mechanisms of p53 Functional De-Regulation: Role of the IκB-α/p53 Complex.
abstract: TP53is one of the most frequently-mutated and deleted tumor suppressors in cancer, with a dramatic correlation with dismal prognoses. In addition to genetic inactivation, the p53 protein can be functionally inactivated in cancer, through post-transductional modifications, changes in cellular compartmentalization, and interactions with other proteins. Here, we review the mechanisms of p53 functional inactivation, with a particular emphasis on the interaction between p53 and IκB-α, theNFKBIAgene product.
authors.affiliation: Department of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, 10043 Turin, Italy. gio.sax2010@hotmail.it.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Carrà
authors.affiliation: Department of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, 10043 Turin, Italy. sabrina.crive@hotmail.it.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Crivellaro
authors.affiliation: Department of Oncology, University of Turin, Regione Gonzole 10, 10043 Turin, Italy. riccardo.taulli@unito.it.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Taulli
authors.affiliation: Department of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, 10043 Turin, Italy. angelo.guerrasio@unito.it.
authors.forename: Angelo
authors.initials: A
authors.lastname: Guerrasio
authors.affiliation: Department of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, 10043 Turin, Italy. giuseppe.saglio@unito.it.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Saglio
authors.affiliation: Department of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, 10043 Turin, Italy. alessandro.morotti@unito.it.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Morotti
mesh_terms: D000818:Animals; D006801:Humans; D009154:Mutation; D000072000:NF-KappaB Inhibitor alpha / Q000235:genetics / Q000378:metabolism*; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism*
chemical_list: D016159:Tumor Suppressor Protein p53; D000072000:NF-KappaB Inhibitor alpha
keywords: IκB-α; functional inactivation; p53; tumor suppressors