title: Prescott tests of equality in binary data under a three-treatment three-period crossover design.
abstract: Three test procedures accounting for patients with tied responses based on Prescott's ideas are developed for comparing three treatments under a three-period crossover trial in binary data. Monte Carlo simulation is employed to evaluate the performance of these test procedures in a variety of situations. The test procedures proposed here are noted to have power larger than those procedures, which utilize only those patients with un-tied responses. The data taken from a three-period crossover trial comparing two different doses of an analgesic with placebo for the relief of primary dysmenorrhea are used to illustrate the use of the test procedures developed here.
authors.affiliation: a Department of Mathematics and Statistics, College of Sciences , San Diego State University , San Diego , California , USA.
authors.forename: Lixia
authors.initials: L
authors.lastname: Zhu
authors.affiliation: a Department of Mathematics and Statistics, College of Sciences , San Diego State University , San Diego , California , USA.
authors.forename: Kung-Jong
authors.initials: KJ
authors.lastname: Lui
mesh_terms: D000700:Analgesics / Q000627:therapeutic use; D002986:Clinical Trials as Topic / Q000706:statistics & numerical data*; D018592:Cross-Over Studies; D003627:Data Interpretation, Statistical; D004412:Dysmenorrhea / Q000188:drug therapy / Q000453:epidemiology; D005260:Female; D006801:Humans; D009010:Monte Carlo Method; D016896:Treatment Outcome
chemical_list: D000700:Analgesics
keywords: Crossover trial; Mantel–Haenszel estimator; Prescott’s test; power; type I error; weighted-least-squares estimator