title: Body mass index is related with the presence of syndesmophyte in axial spondyloarthritis: Data from the Korean College of Rheumatology BIOlogics (KOBIO) registry.
abstract: OBJECTIVE
  We investigated whether body mass index (BMI) is associated with parameters of disease activity and clinical manifestations in axial spondyloarthritis (axSpA).
  
  
  METHODS
  Demographic, clinical, and radiological features and disease activity indexes from 789 axSpA patients (619 males and 170 females) were obtained from the Korean College of Rheumatology BIOlogics (KOBIO) registry. BMI (kg/m2) was classified into normal (BMI <23.0), overweight (23.0 ≤ BMI <25.0), and obese (BMI ≥25.0). Disease activity indexes included Bath ankylosing spondylitis disease activity index (BASDAI), erythrocyte sediment rate (ESR), C-reactive protein (CRP), and ankylosing spondylitis disease activity score (ASDAS).
  
  
  RESULTS
  The mean BMI in patients with axSpA was 23.3 ± 3.5. 50.2% of all patients were overweight or obese. Overweight/obese patients had more syndesmophyte and less peripheral arthritis than those in normal BMI patients (p < 0.001 and p < 0.030, respectively). BMI was not associated with disease activity indexes in axSpA patients. Patients with syndesmophyte had higher BMI than those without syndesmophyte (24.2 ± 3.6 vs. 22.9 ± 3.3, p < 0.001). Multivariate logistic regression analysis showed that increased BMI was closely related with the presence of syndesmophyte (OR = 1.086, 95% CI 1.031-1.143, p = 0.002) Conclusions: Our results imply that increased BMI is significantly associated with the presence of syndesmophyte, but not with disease activity in axSpA.
authors.affiliation: a Department of Internal Medicine, Division of Rheumatology , Arthritis & Autoimmunity Research Center, Catholic University of Daegu School of Medicine , Daegu , South Korea.
authors.forename: Seong-Kyu
authors.initials: SK
authors.lastname: Kim
authors.affiliation: a Department of Internal Medicine, Division of Rheumatology , Arthritis & Autoimmunity Research Center, Catholic University of Daegu School of Medicine , Daegu , South Korea.
authors.forename: Jung-Yoon
authors.initials: JY
authors.lastname: Choe
authors.affiliation: b Department of Rheumatology , Chonnam National University Medical School , Gwangju , South Korea , and.
authors.forename: Shin-Seok
authors.initials: SS
authors.lastname: Lee
authors.affiliation: c Department of Internal Medicine, Division of Rheumatology , Seoul Metropolitan Government-Seoul National University Boramae Medical Center , Seoul , South Korea.
authors.forename: Kichul
authors.initials: K
authors.lastname: Shin
mesh_terms: D000328:Adult; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology; D062072:Patient Acuity; D011859:Radiography / Q000379:methods; D012042:Registries / Q000706:statistics & numerical data; D056910:Republic of Korea / Q000453:epidemiology; D012307:Risk Factors; D012720:Severity of Illness Index; D013131:Spine / Q000000981:diagnostic imaging; D025241:Spondylarthritis / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology; D013223:Statistics as Topic
chemical_list: D002097:C-Reactive Protein
keywords: Body mass index; Disease activity; Spondyloarthritis; Syndesmophyte