title: Metal-free18F-labeling of aryl-CF2H via nucleophilic radiofluorination and oxidative C-H activation.
abstract: A metal-free and selective method to form [18F]aryl-CF2H through nucleophilic radiofluorination of benzyl (pseudo)halides and oxidative C-H activation of benzylic C-H bonds has been developed. The method is operationally simple and tolerates a variety of electron-neutral/deficient arenes and heteroarenes.
authors.affiliation: Gordon Center for Medical Imaging & Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Department of Radiology, Harvard Medical School, 55 Fruit St., Boston, MA 02114, USA. liang.steven@mgh.harvard.edu and Department of Chemistry & Chemical Biology, Northeastern University, 360 Huntington Ave., Boston, MA 02115, USA.
authors.forename: Gengyang
authors.initials: G
authors.lastname: Yuan
authors.affiliation: State Key Laboratory and Institute of Elemento-Organic Chemistry, Nankai University, Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, 300071, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
authors.affiliation: Gordon Center for Medical Imaging & Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Department of Radiology, Harvard Medical School, 55 Fruit St., Boston, MA 02114, USA. liang.steven@mgh.harvard.edu.
authors.forename: Nickeisha A
authors.initials: NA
authors.lastname: Stephenson
authors.affiliation: Gordon Center for Medical Imaging & Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Department of Radiology, Harvard Medical School, 55 Fruit St., Boston, MA 02114, USA. liang.steven@mgh.harvard.edu.
authors.forename: Lu
authors.initials: L
authors.lastname: Wang
authors.affiliation: Gordon Center for Medical Imaging & Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Department of Radiology, Harvard Medical School, 55 Fruit St., Boston, MA 02114, USA. liang.steven@mgh.harvard.edu.
authors.forename: Benjamin H
authors.initials: BH
authors.lastname: Rotstein
authors.affiliation: Gordon Center for Medical Imaging & Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Department of Radiology, Harvard Medical School, 55 Fruit St., Boston, MA 02114, USA. liang.steven@mgh.harvard.edu.
authors.forename: Neil
authors.initials: N
authors.lastname: Vasdev
authors.affiliation: State Key Laboratory and Institute of Elemento-Organic Chemistry, Nankai University, Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, 300071, China.
authors.forename: Pingping
authors.initials: P
authors.lastname: Tang
authors.affiliation: Gordon Center for Medical Imaging & Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Department of Radiology, Harvard Medical School, 55 Fruit St., Boston, MA 02114, USA. liang.steven@mgh.harvard.edu.
authors.forename: Steven H
authors.initials: SH
authors.lastname: Liang
mesh_terms: D001554:Benzene / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D005462:Fluorine Radioisotopes / Q000737:chemistry*; D054879:Halogenation; D006859:Hydrogen / Q000737:chemistry*; D007553:Isotope Labeling / Q000379:methods*; D010084:Oxidation-Reduction
chemical_list: D005462:Fluorine Radioisotopes; D002244:Carbon; D006859:Hydrogen; D001554:Benzene