title: Activity of vancomycin release from bioinspired coatings of hydroxyapatite or TiO2nanotubes.
abstract: Herein we investigate the efficiency of various biomimetic coatings for localized drug delivery, using vancomycin as key therapeutic drug, which is a widely used antibiotic for the treatment of strong infections caused by positive Gram bacteria. We evaluate classical hydroxyapatite and biomimetic hydroxyapatite-collagen coatings obtained by electrochemical deposition as well as TiO2nanotubes arrays obtained by electrochemical anodization. Surface morphology, compositional and structural data confirm the incorporation of vancomycin into the layers and drug release profiles for vancomycin evaluate their release ability. Namely, hydroxyapatite coatings lead to a ≈92% vancomycin release after 30h and hydroxyapatite-collagen to 85%, while the TiO2nanotubes layers lead to 78% release. The antibacterial effect of such drug loaded coatings is evaluated against S. aureus (Gram-positive bacteria). Our study shows that the vancomycin incorporated hydroxyapatite coatings lead to a faster release, while the nanotubular coatings may lead to longer time release and additionally both types of coatings ensure a good antibacterial inhibition.
authors.affiliation: General Chemistry Department, University Politehnica of Bucharest, Polizu 1-7, 011061, Bucharest, Romania.
authors.forename: Daniela
authors.initials: D
authors.lastname: Ionita
authors.affiliation: General Chemistry Department, University Politehnica of Bucharest, Polizu 1-7, 011061, Bucharest, Romania.
authors.forename: Daniela
authors.initials: D
authors.lastname: Bajenaru-Georgescu
authors.affiliation: Buftea M. Burghele Hospital, Studioului 5, Buftea, Romania.
authors.forename: Georgeta
authors.initials: G
authors.lastname: Totea
authors.affiliation: Department of Materials Science Engineering, WW4-LKO, University of Erlangen-Nuremberg Martensstrasse 7, D-91058, Erlangen, Germany. Electronic address: anca.mazare@fau.de.
authors.forename: Anca
authors.initials: A
authors.lastname: Mazare
authors.affiliation: Department of Materials Science Engineering, WW4-LKO, University of Erlangen-Nuremberg Martensstrasse 7, D-91058, Erlangen, Germany.
authors.forename: Patrik
authors.initials: P
authors.lastname: Schmuki
authors.affiliation: General Chemistry Department, University Politehnica of Bucharest, Polizu 1-7, 011061, Bucharest, Romania.
authors.forename: Ioana
authors.initials: I
authors.lastname: Demetrescu
mesh_terms: D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D003094:Collagen / Q000737:chemistry; D065546:Drug Liberation; D017886:Durapatite / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D043942:Nanotubes / Q000737:chemistry* / Q000648:ultrastructure; D014025:Titanium / Q000737:chemistry*; D014640:Vancomycin / Q000737:chemistry / Q000493:pharmacokinetics* / Q000494:pharmacology*
chemical_list: D020099:Coated Materials, Biocompatible; C009495:titanium dioxide; D014640:Vancomycin; D003094:Collagen; D017886:Durapatite; D014025:Titanium
keywords: Hydroxyapatite; Hydroxyapatite-collagen coatings; S. aureus; TiO(2) nanotubes; Vancomycin