title: Intensive Circulation of Japanese Encephalitis Virus in Peri-urban Sentinel Pigs near Phnom Penh, Cambodia.
abstract: Despite the increased use of vaccination in several Asian countries, Japanese Encephalitis (JE) remains the most important cause of viral encephalitis in Asia in humans with an estimated 68,000 cases annually. Considered a rural disease occurring mainly in paddy-field dominated landscapes where pigs are amplifying hosts, JE may nevertheless circulate in a wider range of environment given the diversity of its potential hosts and vectors. The main objective of this study was to assess the intensity of JE transmission to pigs in a peri-urban environment in the outskirt of Phnom Penh, Cambodia. We estimated the force of JE infection in two cohorts of 15 sentinel pigs by fitting a generalised linear model on seroprevalence monitoring data observed during two four-month periods in 2014. Our results provide evidence for intensive circulation of JE virus in a periurban area near Phnom Penh, the capital and most populated city of Cambodia. Understanding JE virus transmission in different environments is important for planning JE virus control in the long term and is also an interesting model to study the complexity of vector-borne diseases. Collecting quantitative data such as the force of infection will help calibrate epidemiological model that can be used to better understand complex vector-borne disease epidemiological cycles.
authors.affiliation: CIRAD-ES, UPR AGIRs, Montpellier, France.|Institut Pasteur du Cambodge, Epidemiology and Public Health Unit, Phnom Penh, Cambodia.
authors.forename: Julien
authors.initials: J
authors.lastname: Cappelle
authors.affiliation: Institut Pasteur du Cambodge, Virology Unit, Phnom Penh, Cambodia.
authors.forename: Veasna
authors.initials: V
authors.lastname: Duong
authors.affiliation: Royal University of Agriculture, Phnom Penh, Cambodia.
authors.forename: Long
authors.initials: L
authors.lastname: Pring
authors.affiliation: Royal University of Agriculture, Phnom Penh, Cambodia.
authors.forename: Lida
authors.initials: L
authors.lastname: Kong
authors.affiliation: Institut Pasteur du Cambodge, Epidemiology and Public Health Unit, Phnom Penh, Cambodia.
authors.forename: Maud
authors.initials: M
authors.lastname: Yakovleff
authors.affiliation: United States Naval Medical Research Unit 2, Phnom Penh, Cambodia.
authors.forename: Didot Budi
authors.initials: DB
authors.lastname: Prasetyo
authors.affiliation: Institut Pasteur du Cambodge, Virology Unit, Phnom Penh, Cambodia.
authors.forename: Borin
authors.initials: B
authors.lastname: Peng
authors.affiliation: Institut Pasteur du Cambodge, Virology Unit, Phnom Penh, Cambodia.
authors.forename: Rithy
authors.initials: R
authors.lastname: Choeung
authors.affiliation: CIRAD-ES, UPR AGIRs, Montpellier, France.|Institut Pasteur du Cambodge, Epidemiology and Public Health Unit, Phnom Penh, Cambodia.
authors.forename: Raphaël
authors.initials: R
authors.lastname: Duboz
authors.affiliation: Institut Pasteur du Cambodge, Virology Unit, Phnom Penh, Cambodia.
authors.forename: Sivuth
authors.initials: S
authors.lastname: Ong
authors.affiliation: National Veterinary Research Institute, Phnom Penh, Cambodia.
authors.forename: San
authors.initials: S
authors.lastname: Sorn
authors.affiliation: Institut Pasteur du Cambodge, Virology Unit, Phnom Penh, Cambodia.
authors.forename: Philippe
authors.initials: P
authors.lastname: Dussart
authors.affiliation: Institut Pasteur du Cambodge, Epidemiology and Public Health Unit, Phnom Penh, Cambodia.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Tarantola
authors.affiliation: GlaxoSmithKline Vaccines R&D, Singapore, Singapore.
authors.forename: Philippe
authors.initials: P
authors.lastname: Buchy
authors.affiliation: CIRAD-ES, UPR AGIRs, Montpellier, France.
authors.forename: Véronique
authors.initials: V
authors.lastname: Chevalier
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D002160:Cambodia / Q000453:epidemiology; D015331:Cohort Studies; D003465:Culex / Q000821:virology; D004664:Encephalitis Virus, Japanese / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D004672:Encephalitis, Japanese / Q000097:blood / Q000453:epidemiology / Q000662:veterinary* / Q000821:virology; D005260:Female; D007303:Insect Vectors / Q000821:virology; D012621:Seasons; D016036:Seroepidemiologic Studies; D013552:Swine; D013553:Swine Diseases / Q000097:blood / Q000453:epidemiology / Q000635:transmission / Q000821:virology*
chemical_list: D000914:Antibodies, Viral