title: Loss of pulse pressure amplification between the ascending and descending aorta in patients after an aortic arch repair.
abstract: One of the most important problems in patients with an aortic coarctation after an aortic arch repair is future cardiovascular disease. We previously reported the enhancement of the aortic pressure wave reflection in patients and hypothesized that the enhancement was caused by a new pressure wave reflection generated from the repaired site. To prove the hypothesis, we analyzed the pressure waveform in the ascending and descending aorta and examined their pulse pressure (PP) amplification.
  
  
  
  Fifteen patients after an aortic arch repair without a recoarctation were enrolled. The ascending and descending aorta pressure waveforms were recorded by a pressure sensor mounted catheter. The pressures were compared with those of age-matched controls.
  
  
  
  The patient's age was 7.3 ± 2.7 years, and they underwent the aortic arch repair at 30.1 ± 29.0 days. The ascending aorta SBP (106.1 ± 12.7 mmHg) was higher than in the control patients (97.9 ± 14.3) (P = 0.015). The PP at the ascending aorta in the patients (41.3 ± 7.8) was wider than that in the controls (36.4 ± 5.0) (P = 0.010). There was no difference concerning the PP at the descending aorta between the patients (41.0 ± 7.7) and controls (40.5 ± 6.5). The difference in the PP between the descending and ascending aorta (PP at the descending aorta - PP at the ascending aorta) in the patients was -0.3 ± 1.7 and 5.1 ± 2.9 in the controls (P < 0.0001).
  
  
  
  The ascending aortic PP was augmented in the patients after the aortic arch repair. It could be one of the causes of future cardiovascular disease.
authors.affiliation: aDepartment of Cardiology, Chiba Children's Hospital, Chiba bDepartment of Pediatrics, Hokkaido University Hospital, Sapporo, Japan.
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Murakami
authors.forename: Masahiro
authors.initials: M
authors.lastname: Shiraishi
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Nawa
authors.forename: Atsuhito
authors.initials: A
authors.lastname: Takeda
mesh_terms: D001011:Aorta / Q000503:physiopathology; D001013:Aorta, Thoracic / Q000503:physiopathology* / Q000601:surgery*; D001017:Aortic Coarctation / Q000601:surgery*; D062186:Arterial Pressure; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D063177:Pulse Wave Analysis