title: Platinum Complex Assemblies as Luminescent Probes and Tags for Drugs and Toxins in Water.
abstract: A reactive phosphorescent probe for aza-heterocyclic drugs and toxins was developed, affording a supramolecular emission-switch-on chemosensor in water. Complex formation of the heterocycles with a platinum(II) precursor proceeds readily at ambient conditions, allowing for facile analyte screening. Fifty-two structurally diverse compounds were tested, out of which 23 pyridines, imidazoles, and triazoles formed strongly emissive complex aggregates. Importantly, they all can be clearly distinguished from each other through a principal component analysis, but often also by simple visual inspection, for example, by their emission color differences (large shifts from blue to red). Also, kinetic reaction profiles and time-resolved emission features can provide valuable information for analyte distinction. The PtIIcomplexes can be applied as emissive labels for drugs and biomolecules, owing to their advantageous photophysical properties and chemical stability in biological media such as blood.
authors.affiliation: Institut de Science et d'Ingénierie Supramoléculaires (ISIS), Université de Strasbourg & CNRS, 8 Rue Gaspard Monge, 67000, Strasbourg, France.
authors.forename: Stephan
authors.initials: S
authors.lastname: Sinn
authors.affiliation: Institute for Nanotechnology (INT), Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, 76344, Eggenstein-Leopoldshafen, Germany.
authors.forename: Frank
authors.initials: F
authors.lastname: Biedermann
authors.affiliation: Institut de Science et d'Ingénierie Supramoléculaires (ISIS), Université de Strasbourg & CNRS, 8 Rue Gaspard Monge, 67000, Strasbourg, France.|Institute for Nanotechnology (INT), Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, 76344, Eggenstein-Leopoldshafen, Germany.
authors.forename: Luisa
authors.initials: L
authors.lastname: De Cola
mesh_terms: D001372:Aza Compounds / Q000737:chemistry; D056831:Coordination Complexes / Q000737:chemistry*; D016002:Discriminant Analysis; D049408:Luminescent Agents / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000032:analysis* / Q000737:chemistry; D010984:Platinum / Q000737:chemistry*; D025341:Principal Component Analysis; D013501:Surface-Active Agents / Q000737:chemistry; D014118:Toxins, Biological / Q000032:analysis* / Q000737:chemistry; D014873:Water Pollutants / Q000032:analysis* / Q000737:chemistry
chemical_list: D001372:Aza Compounds; D056831:Coordination Complexes; D049408:Luminescent Agents; D004364:Pharmaceutical Preparations; D013501:Surface-Active Agents; D014118:Toxins, Biological; D014873:Water Pollutants; D010984:Platinum
keywords: aggregation-induced emission; differential sensing; fluorescence assay; heterocycles; self-assembly