title: Neurological manifestations in children with dengue fever: an Indian perspective.
abstract: Ours was a descriptive observational cross-sectional study carried out in a tertiary care hospital in eastern India over a period of one year to study the profile of neurological involvement in paediatric dengue patients. Of 71 laboratory-confirmed cases, 20 (28.17%) had neurological involvement. Common forms observed were acute encephalopathy (40%), encephalitis (30%), pure motor weakness (15%), transverse myelitis (5%), acute disseminated encephalomyelitis (5%) and Guillain-Barré syndrome (5%). The dengue IgM antibody could be detected in the cerebrospinal fluid of only two patients with encephalitis. Neurological involvement was present in all four patients who died during the study period (two-tailed P value = 0.005).
authors.affiliation: 1 Residential Medical Officer and Clinical Tutor, Department of Paediatric Medicine, Burdwan Medical College, Burdwan, India.
authors.forename: Archan
authors.initials: A
authors.lastname: Sil
authors.affiliation: 2 Junior Resident, Department of Paediatric Medicine, Medical College Kolkata, Kolkata, India.
authors.forename: Tamoghna
authors.initials: T
authors.lastname: Biswas
authors.affiliation: 3 Associate Professor, Department of Paediatric Medicine, Nil Ratan Sircar Medical College, India.
authors.forename: Moumita
authors.initials: M
authors.lastname: Samanta
authors.affiliation: 4 Assistant Professor, Department of Paediatric Medicine, Burdwan Medical College, Burdwan, India.
authors.forename: Mithun Chandra
authors.initials: MC
authors.lastname: Konar
authors.affiliation: 5 Professor, Department of Paediatric Medicine, Midnapore Medical College, Midnapore, India.
authors.forename: Arun Kumar
authors.initials: AK
authors.lastname: De
authors.affiliation: 6 Residential Medical Officer and Clinical Tutor, Department of Paediatric Medicine, Medical College Kolkata, Kolkata, India.
authors.forename: Jasodhara
authors.initials: J
authors.lastname: Chaudhuri
mesh_terms: D000914:Antibodies, Viral / Q000134:cerebrospinal fluid; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D003715:Dengue / Q000134:cerebrospinal fluid / Q000150:complications*; D003716:Dengue Virus / Q000276:immunology; D005260:Female; D020275:Guillain-Barre Syndrome; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood / Q000134:cerebrospinal fluid; D007194:India / Q000453:epidemiology; D007223:Infant; D008297:Male; D009422:Nervous System Diseases / Q000134:cerebrospinal fluid / Q000453:epidemiology / Q000821:virology*
chemical_list: D000914:Antibodies, Viral; D007075:Immunoglobulin M
keywords: Dengue fever; diseases; nervous; physiology