title: Stable, long-term, spatial memory in young and aged rats achieved with a one day Morris water maze training protocol.
abstract: Here, we present data demonstrating that a 1 d Morris water maze training protocol is effective at producing stable, long-term spatial memory in both young (3 mo old) and aged (24 mo old) F344xBN rats. Four trials in each of four sessions separated by a 2.5 h ISI produced robust selective search for the platform 1 and 4 d after training, in both age groups. A 1 h ISI protocol did not produce good retention. Also, compressing the trials into just two sessions separated by a 2.5 h ISI produced limited retention in only young rats.
authors.affiliation: Department of Psychology and Neuroscience, Center for Neuroscience, University of Colorado Boulder, Boulder, Colorado 80309-0345, USA ruth.barrientos@colorado.edu.
authors.forename: Ruth M
authors.identifier: 0000-0001-7224-4109
authors.initials: RM
authors.lastname: Barrientos
authors.affiliation: Department of Psychology and Neuroscience, Center for Neuroscience, University of Colorado Boulder, Boulder, Colorado 80309-0345, USA.
authors.forename: Meagan M
authors.initials: MM
authors.lastname: Kitt
authors.affiliation: Department of Psychology and Neuroscience, Center for Neuroscience, University of Colorado Boulder, Boulder, Colorado 80309-0345, USA.
authors.forename: Heather M
authors.initials: HM
authors.lastname: D'Angelo
authors.affiliation: Department of Psychology and Neuroscience, Center for Neuroscience, University of Colorado Boulder, Boulder, Colorado 80309-0345, USA.
authors.forename: Linda R
authors.initials: LR
authors.lastname: Watkins
authors.affiliation: Department of Psychology and Neuroscience, Center for Neuroscience, University of Colorado Boulder, Boulder, Colorado 80309-0345, USA.
authors.forename: Jerry W
authors.initials: JW
authors.lastname: Rudy
authors.affiliation: Department of Psychology and Neuroscience, Center for Neuroscience, University of Colorado Boulder, Boulder, Colorado 80309-0345, USA.
authors.forename: Steven F
authors.initials: SF
authors.lastname: Maier
mesh_terms: D000375:Aging / Q000523:psychology*; D000818:Animals; D008297:Male; D018782:Maze Learning; D057567:Memory, Long-Term; D011581:Psychological Tests; D011916:Rats, Inbred F344; D065852:Spatial Memory; D013997:Time Factors