title: Proceedings of the Fourth Annual Deep Brain Stimulation Think Tank: A Review of Emerging Issues and Technologies.
abstract: This paper provides an overview of current progress in the technological advances and the use of deep brain stimulation (DBS) to treat neurological and neuropsychiatric disorders, as presented by participants of the Fourth Annual DBS Think Tank, which was convened in March 2016 in conjunction with the Center for Movement Disorders and Neurorestoration at the University of Florida, Gainesveille FL, USA. The Think Tank discussions first focused on policy and advocacy in DBS research and clinical practice, formation of registries, and issues involving the use of DBS in the treatment of Tourette Syndrome. Next, advances in the use of neuroimaging and electrochemical markers to enhance DBS specificity were addressed. Updates on ongoing use and developments of DBS for the treatment of Parkinson's disease, essential tremor, Alzheimer's disease, depression, post-traumatic stress disorder, obesity, addiction were presented, and progress toward innovation(s) in closed-loop applications were discussed. Each section of these proceedings provides updates and highlights of new information as presented at this year's international Think Tank, with a view toward current and near future advancement of the field.
authors.affiliation: Department of Neurology, Center for Movement Disorders and Neurorestoration, University of Florida Gainesville, FL, USA.
authors.forename: Wissam
authors.initials: W
authors.lastname: Deeb
authors.affiliation: Department of Neurology, and Neuroethics Studies Program, Pellegrino Center for Clinical Bioethics, Georgetown University Medical Center Washington, DC, USA.
authors.forename: James J
authors.initials: JJ
authors.lastname: Giordano
authors.affiliation: Department of Neurology, Center for Movement Disorders and Neurorestoration, University of Florida Gainesville, FL, USA.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Rossi
authors.affiliation: Department of Neurosurgery, Center for Neuromodulation, New York University Langone Medical Center New York, NY, USA.
authors.forename: Alon Y
authors.initials: AY
authors.lastname: Mogilner
authors.affiliation: Department of Neurology, Center for Movement Disorders and Neurorestoration, University of FloridaGainesville, FL, USA; J. Crayton Pruitt Family Department of Biomedical Engineering, University of FloridaGainesville, FL, USA.
authors.forename: Aysegul
authors.initials: A
authors.lastname: Gunduz
authors.affiliation: Department of Neurology, Center for Movement Disorders and Neurorestoration, University of FloridaGainesville, FL, USA; J. Crayton Pruitt Family Department of Biomedical Engineering, University of FloridaGainesville, FL, USA.
authors.forename: Jack W
authors.initials: JW
authors.lastname: Judy
authors.affiliation: Department of Neurology, Mayo Clinic Rochester, MN, USA.
authors.forename: Bryan T
authors.initials: BT
authors.lastname: Klassen
authors.affiliation: Department of Bioengineering, Scientific Computing and Imaging Institute, University of Utah Salt Lake City, UT, USA.
authors.forename: Christopher R
authors.initials: CR
authors.lastname: Butson
authors.affiliation: Department of Neurosurgery, University of Kentucky Chandler Medical Center Lexington, KY, USA.
authors.forename: Craig
authors.initials: C
authors.lastname: Van Horne
authors.affiliation: Department of Psychiatry, Academic Medical Center, University of Amsterdam Amsterdam, Netherlands.
authors.forename: Damiaan
authors.initials: D
authors.lastname: Deny
authors.affiliation: Department of Psychiatry, Massachusetts General Hospital Boston, MA, USA.
authors.forename: Darin D
authors.initials: DD
authors.lastname: Dougherty
authors.affiliation: Asia Pacific Centre for Neuromodulation, Queensland Brain Institute, The University of Queensland Brisbane, QLD, Australia.
authors.forename: David
authors.initials: D
authors.lastname: Rowell
authors.affiliation: Department of Anatomy and Neurobiology, University of Kentucky Chandler Medical Center Lexington, KY, USA.
authors.forename: Greg A
authors.initials: GA
authors.lastname: Gerhardt
authors.affiliation: Departments of Psychiatry and Behavioral Sciences and Radiology and Radiological Sciences, Johns Hopkins University School of Medicine Baltimore, MD, USA.
authors.forename: Gwenn S
authors.initials: GS
authors.lastname: Smith
authors.affiliation: Division of Neurological Surgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center Phoenix Arizona, AZ, USA.
authors.forename: Francisco A
authors.initials: FA
authors.lastname: Ponce
authors.affiliation: Department of Neurology and Department of Biomedical Engineering, University of Alabama at Birmingham Birmingham, AL, USA.
authors.forename: Harrison C
authors.initials: HC
authors.lastname: Walker
authors.affiliation: Departments of Neurology and Neurological Sciences and Neurosurgery, Stanford University Stanford, CA, USA.
authors.forename: Helen M
authors.initials: HM
authors.lastname: Bronte-Stewart
authors.affiliation: Department of Psychiatry, Emory University School of Medicine Atlanta, GA, USA.
authors.forename: Helen S
authors.initials: HS
authors.lastname: Mayberg
authors.affiliation: Electrical Engineering Department, University of WashingtonSeattle, WA, USA; NSF Engineering Research Center for Sensorimotor Neural EngineeringSeattle, WA, USA.
authors.forename: Howard J
authors.initials: HJ
authors.lastname: Chizeck
authors.affiliation: Department of Neurosurgery, VA Greater Los Angeles Healthcare System Los Angeles, CA, USA.
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Langevin
authors.affiliation: Department of Neurology, University Clinic of Würzburg Würzburg, Germany.
authors.forename: Jens
authors.initials: J
authors.lastname: Volkmann
authors.affiliation: Department of Neurology, University of California San Francisco San Francisco, CA, USA.
authors.forename: Jill L
authors.initials: JL
authors.lastname: Ostrem
authors.affiliation: J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida Gainesville, FL, USA.
authors.forename: Jonathan B
authors.initials: JB
authors.lastname: Shute
authors.affiliation: Department of Neurology, Baylor College of Medicine Houston, TX, USA.
authors.forename: Joohi
authors.initials: J
authors.lastname: Jimenez-Shahed
authors.affiliation: Department of Neurology, Center for Movement Disorders and Neurorestoration, University of FloridaGainesville, FL, USA; Department of Neurological Sciences, University of FloridaGainesville, FL, USA.
authors.forename: Kelly D
authors.initials: KD
authors.lastname: Foote
authors.affiliation: Department of Neurology, Center for Movement Disorders and Neurorestoration, University of Florida Gainesville, FL, USA.
authors.forename: Aparna
authors.initials: A
authors.lastname: Wagle Shukla
authors.affiliation: Departments of Neurological Sciences, Diagnostic Radiology, and Nuclear Medicine, Rush University Medical Center Chicago, IL, USA.
authors.forename: Marvin A
authors.initials: MA
authors.lastname: Rossi
authors.affiliation: Division of Functional Neurosurgery, Department of Neurosurgery, Allegheny General Hospital Pittsburgh, PA, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Oh
authors.affiliation: Department of Neurology, New York University Langone Medical Center New York, NY, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Pourfar
authors.affiliation: Psychiatry and Behavioral Sciences, Johns Hopkins Bayview Medical Center, Johns Hopkins School of Medicine Baltimore, MD, USA.
authors.forename: Paul B
authors.initials: PB
authors.lastname: Rosenberg
authors.affiliation: Asia Pacific Centre for Neuromodulation, Queensland Brain Institute, The University of Queensland Brisbane, QLD, Australia.
authors.forename: Peter A
authors.initials: PA
authors.lastname: Silburn
authors.affiliation: Graduate Program in Neuroscience, Department of Neurological Surgery, Kavli Institute for Fundamental Neuroscience, University of California, San Francisco San Francisco, CA, USA.
authors.forename: Coralie
authors.initials: C
authors.lastname: de Hemptine
authors.affiliation: Graduate Program in Neuroscience, Department of Neurological Surgery, Kavli Institute for Fundamental Neuroscience, University of California, San Francisco San Francisco, CA, USA.
authors.forename: Philip A
authors.initials: PA
authors.lastname: Starr
authors.affiliation: Medtronic Modulation Minneapolis, MN, USA.
authors.forename: Timothy
authors.initials: T
authors.lastname: Denison
authors.affiliation: Movement Disorders Program, Department of Neurology, Alpert Medical School, Rhode Island Hospital, Brown University Providence, RI, USA.
authors.forename: Umer
authors.initials: U
authors.lastname: Akbar
authors.affiliation: Department of Biomedical Engineering, Duke University Durham, NC, USA.
authors.forename: Warren M
authors.initials: WM
authors.lastname: Grill
authors.affiliation: Department of Neurology, Center for Movement Disorders and Neurorestoration, University of Florida Gainesville, FL, USA.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Okun
keywords: Alzheimer's disease; DARPA; Parkinson's disease; Tourette syndrome; closed-loop; deep brain stimulation; depression; post-traumatic stress disorder