title: Outcome of Gastric Cancer Surgery in Patients with Chronic Kidney Disease.
abstract: BACKGROUND
  The influence of chronic kidney disease (CKD) on the outcome of gastric cancer surgery has rarely been reported.
  
  
  METHODS
  Retrospectively collected clinicopathological data on patients who underwent elective gastrectomy between January 2007 and December 2014 were analyzed (n = 500). The patients were divided into 2 groups based on the preoperative estimated glomerular filtration rate (eGFR): a non-CKD group (eGFR ≥60 ml/min/1.73 m2, n = 392) and a CKD group (eGFR <60 ml/min/1.73 m2, n = 108). Short- and long-term results of the surgery were compared.
  
  
  RESULTS
  There was no significant difference between the 2 groups in terms of the overall morbidity rate (p = 0.215), and in any kind of postoperative complication, including infectious and cardiovascular complications. Additionally, there was no significant difference in the morbidity rate irrespective of the type of gastrectomy and the extent of lymph node dissection. The 3-year relapse-free survival rates in the non-CKD and CKD groups were 92.1 and 92.0%, respectively, in stage I disease (p = 0.640), 81.4 and 73.7%, respectively, in stage II disease (p = 0.825), and 35.9 and 31.9%, respectively, in stage III disease (p = 0.784).
  
  
  CONCLUSIONS
  CKD did not affect the short- and long-term outcomes in patients after gastric cancer surgery.
authors.affiliation: Department of Surgery, Yodogawa Christian Hospital, Osaka, Japan.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Wakahara
authors.forename: Nozomi
authors.initials: N
authors.lastname: Ueno
authors.forename: Shohei
authors.initials: S
authors.lastname: Komatsu
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ashitani
authors.forename: Shinobu
authors.initials: S
authors.lastname: Tsuchida
authors.forename: Akihiro
authors.initials: A
authors.lastname: Toyokawa
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D018572:Disease-Free Survival; D005260:Female; D005743:Gastrectomy / Q000009:adverse effects*; D005919:Glomerular Filtration Rate; D006801:Humans; D008197:Lymph Node Excision / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011183:Postoperative Complications / Q000209:etiology*; D051436:Renal Insufficiency, Chronic / Q000150:complications* / Q000503:physiopathology; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery*; D016896:Treatment Outcome
keywords: Chronic kidney disease; Gastric cancer; Surgery