title: Chromosome folding and its regulation in health and disease.
abstract: There are many ways in which cells may not adequately behave or respond to their environment, and the molecular mechanisms leading to these defects are as diverse as they are many. In this review, we report on how spatial chromatin organization contributes to the proper expression of genes, relating how CTCF-one of its main architects-contributes to gene regulation. We also touch on the emerging role of long noncoding RNAs in shaping chromatin organization and activity. The HOX gene clusters have been used as paradigm in the study of various biological pathways, and the overview we provide gives emphasis to what research on these loci has revealed about chromatin architecture and its regulation in the control of gene expression.
authors.affiliation: Department of Biochemistry and Goodman Cancer Research Center, McGill University, 3655 Promenade Sir-William-Osler, Room 815A, Montréal, Québec, Canada H3G1Y6.
authors.forename: Xue Qing David
authors.initials: XQD
authors.lastname: Wang
authors.affiliation: Department of Biochemistry and Goodman Cancer Research Center, McGill University, 3655 Promenade Sir-William-Osler, Room 815A, Montréal, Québec, Canada H3G1Y6. Electronic address: josee.dostie@mcgill.ca.
authors.forename: Josée
authors.initials: J
authors.lastname: Dostie
mesh_terms: D000818:Animals; D000076246:CCCTC-Binding Factor / Q000235:genetics*; D002843:Chromatin / Q000235:genetics*; D002875:Chromosomes / Q000235:genetics*; D005786:Gene Expression Regulation / Q000235:genetics; D005801:Genes, Homeobox / Q000235:genetics*; D006801:Humans; D062085:RNA, Long Noncoding / Q000235:genetics; D012097:Repressor Proteins / Q000235:genetics
chemical_list: D000076246:CCCTC-Binding Factor; C000619697:CTCF protein, human; D002843:Chromatin; D062085:RNA, Long Noncoding; D012097:Repressor Proteins