title: Impaired Left Atrial Conduit Function in Coronary Artery Disease Patients With Poorly Controlled Diabetes: Two-Dimensional Speckle-Tracking Echocardiographic Study.
abstract: OBJECTIVE
  The myocardium can be affected by diabetes mellitus. The effects of blood glucose control on some organs such as the kidney and eye have been previously reported. The aim of our study was to evaluate left atrial function via 2-dimensional (2D) speckle-tracking echocardiography in a group of coronary artery disease (CAD) patients with well-controlled diabetes (hemoglobin A1c [HbA1c] < 7%) and to compare it with that in a group of CAD patients with poorly controlled diabetes.
  
  
  METHODS
  This cross-sectional study included 110 CAD patients, comprising 44 euglycemic control patients, 33 patients with well-controlled diabetes (HbA1c < 7%), and 33 patients with poorly controlled diabetes. The study population thereafter underwent 2D speckle-tracking echocardiography for an evaluation of their left atrial function.
  
  
  RESULTS
  Our findings showed that the absolute values of early diastolic strain and early diastolic strain rate were lower in the CAD patients with poorly controlled diabetes than in the euglycemic control patients with CAD. Moreover, early diastolic strain in the CAD patients with poorly controlled diabetes was lower than that in the CAD patients with well-controlled diabetes. Multivariable analysis revealed that poorly controlled diabetes was an independent determinant of early diastolic strain and strain rate.
  
  
  CONCLUSIONS
  The conduit function of the left atrium was impaired in the CAD patients with poorly controlled diabetes compared with that in the euglycemic control patients with CAD and the CAD patients with well-controlled diabetes.
authors.affiliation: Cardiology Department, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, I.R. Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Hosseinsabet
authors.affiliation: Cardiology Department, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, I.R. Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Mohseni-Badalabadi
authors.affiliation: Cardiology Department, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, I.R. Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Moinfar
mesh_terms: D003324:Coronary Artery Disease / Q000150:complications* / Q000503:physiopathology*; D003430:Cross-Sectional Studies; D048909:Diabetes Complications / Q000000981:diagnostic imaging*; D004452:Echocardiography / Q000379:methods*; D005260:Female; D006325:Heart Atria / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D018487:Ventricular Dysfunction, Left / Q000150:complications* / Q000000981:diagnostic imaging / Q000503:physiopathology*
keywords: 2D speckle-tracking echocardiography; diabetes; left atrium