title: [Cryosclerosis. The forgotten endovenous cryoablation of the great saphenous vein. Mid-term results of a prospective comparative trial].
abstract: BACKGROUND
  Cryosclerosis was introduced by Milleret and Le Pivert in the 1980s.
  
  
  METHODS
  A prospective non-randomized comparative study has been performed on initial 96 patients. 48 patients were treated by cryosclerosis and the others received conventional stripping. 52 cases were analyzed for 2-years. The primary end-point of the study was to determine the occlusion rate of cryosclerosis. The clinical failure, the improvement in the Clinical Etiologic Anatomic Pathophysiologic classification and Venous Clinical Severity Scores were analyzed as secondary outcome.
  
  
  RESULTS
  Total recanalization of the great saphenous vein causing clinical failure was observed in one case (4%). The reopening of the great saphenous vein was observed in 4 limbs (15%) that did not cause the incompetence of the trunk. The occlusion rate was 81%. Recurrent varicosity was observed by 35% and 42% of the patients in the cryosclerosis and stripping groups respectively. There was no significant difference between the groups (log rank test, p = 0.391). There was significant improvement in both the Clinical Etiologic Anatomic Pathophysiologic classification and Venous Clinical Severity Scores in each group without remarkable differences observed between the groups either at baseline or on the mid-term.
  
  
  CONCLUSIONS
  Cryosclerosis seems to be effective in the remodeling of the great saphenous vein. The method has no remarkable mid-term clinical advantages over classical stripping so far. Orv. Hetil., 2016, 157(50), 1994-2001.
authors.affiliation: Általános Sebészeti Osztály, Kanizsai Dorottya Kórház Nagykanizsa, Erkel Ferenc utca 1/1/3., 8800.
authors.forename: István Bence
authors.initials: IB
authors.lastname: Bálint
authors.affiliation: Általános Sebészeti Osztály, Kanizsai Dorottya Kórház Nagykanizsa, Erkel Ferenc utca 1/1/3., 8800.
authors.forename: Ákos
authors.initials: Á
authors.lastname: Farics
authors.affiliation: Általános Sebészeti Osztály, Kanizsai Dorottya Kórház Nagykanizsa, Erkel Ferenc utca 1/1/3., 8800.
authors.forename: László
authors.initials: L
authors.lastname: Vizsy
authors.affiliation: Radiológiai Osztály, Kanizsai Dorottya Kórház Nagykanizsa.
authors.forename: Eszter
authors.initials: E
authors.lastname: Vargovics
authors.affiliation: Pannon Egyetem, Nagykanizsai Kampusz Nagykanizsa.
authors.forename: Renáta
authors.initials: R
authors.lastname: Bálint
authors.affiliation: Általános Sebészeti Osztály, Kanizsai Dorottya Kórház Nagykanizsa, Erkel Ferenc utca 1/1/3., 8800.
authors.forename: József
authors.initials: J
authors.lastname: Bátorfi
authors.affiliation: Érsebészeti Klinika, Pécsi Tudományegyetem, Általános Orvostudományi Kar Pécs.
authors.forename: Gábor
authors.initials: G
authors.lastname: Menyhei
mesh_terms: D003452:Cryosurgery / Q000379:methods*; D005260:Female; D006801:Humans; D008026:Ligation / Q000379:methods; D008297:Male; D019060:Minimally Invasive Surgical Procedures / Q000379:methods; D011446:Prospective Studies; D012501:Saphenous Vein / Q000000981:diagnostic imaging / Q000601:surgery*; D018615:Ultrasonography, Doppler, Color; D014648:Varicose Veins / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery*; D014656:Vascular Surgical Procedures / Q000379:methods; D014689:Venous Insufficiency / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery*
keywords: cryoablatio; cryoablation; cryosclerosis; endovenous thermal ablation; endovénás termális ablatio; great saphenous vein; vena saphena magna