title: Single-fiber EMG with concentric electrodes in lambert-eaton myasthenia.
abstract: We analyzed jitter recordings made with concentric needle electrode (CNE) single-fiber electromyography (SFEMG) in Lambert-Eaton myasthenia (LEM).
  
  
  
  Fifteen subjects diagnosed with LEM were studied using CNE-SFEMG in the extensor digitorum (ED) and tibialis anterior (TA) muscles. CNE-SFEMG in the ED and TA was also used to evaluate 12 and 10 healthy controls (HCs), respectively.
  
  
  
  Ten men and 5 women were diagnosed with LEM based on an increase of 100% in compound muscle action potential amplitude during 50 Hz repetitive nerve stimulation. All patients exhibited markedly greater jitter in the ED (88.8 ± 23.2 µs) and TA (92.2 ± 30.2 µs) than HCs (28.3 ± 3.4 µs and 30.9 ± 5.1 µs, respectively).
  
  
  
  CNE-SFEMG is sensitive for discovering abnormalities in neuromuscular transmission in LEM. Muscle Nerve 56: 253-257, 2017.
authors.affiliation: Department of Neurology, Peking Union Medical College Hospital, No. 1 Shuaifuyuan, Wangfujing, Dongcheng, Beijing, China, 100730.
authors.forename: Yuzhou
authors.initials: Y
authors.lastname: Guan
authors.affiliation: Department of Neurology, Peking Union Medical College Hospital, No. 1 Shuaifuyuan, Wangfujing, Dongcheng, Beijing, China, 100730.
authors.forename: Qingyun
authors.initials: Q
authors.lastname: Ding
authors.affiliation: Department of Neurology, Peking Union Medical College Hospital, No. 1 Shuaifuyuan, Wangfujing, Dongcheng, Beijing, China, 100730.
authors.forename: Mingsheng
authors.initials: M
authors.lastname: Liu
authors.affiliation: Department of Neurology, Peking Union Medical College Hospital, No. 1 Shuaifuyuan, Wangfujing, Dongcheng, Beijing, China, 100730.
authors.forename: Jingwen
authors.initials: J
authors.lastname: Niu
authors.affiliation: Department of Neurology, Peking Union Medical College Hospital, No. 1 Shuaifuyuan, Wangfujing, Dongcheng, Beijing, China, 100730.
authors.forename: Liying
authors.initials: L
authors.lastname: Cui
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000328:Adult; D000368:Aged; D004558:Electric Stimulation; D004566:Electrodes; D004576:Electromyography; D005221:Fatigue / Q000209:etiology; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D015624:Lambert-Eaton Myasthenic Syndrome / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D018485:Muscle Fibers, Skeletal / Q000502:physiology*; D018908:Muscle Weakness / Q000209:etiology; D009431:Neural Conduction / Q000502:physiology; D012018:Reflex / Q000502:physiology; D012189:Retrospective Studies; D018709:Statistics, Nonparametric
chemical_list: D016756:Immunoglobulins, Intravenous
keywords: Lambert-Eaton myasthenia; concentric needle electrode; extensor digitorum; jitter; single fiber electromyography; tibialis anterior