title: Products based on olive oil, betaine, and xylitol in the post-radiotherapy xerostomia.
abstract: OBJECTIVE
  The objective of this study was determining if the use of products based in olive oil, betaine and xylitol are efficacious to decrease the impact of the dry mouth in the quality of life of the patients with xerostomia due to radiotherapy treatment.
  
  
  BACKGROUND
  Following therapeutic irradiation of the head and neck, patients with profound xerostomia have complaints associated with oral dryness, speech, and taste. There is no strong evidence that any topical therapy is effective for relieving the symptom of dry mouth.
  
  
  METHODS
  40 patients who had been treated with radiotherapy for head and neck carcinoma and reported symptoms of dry mouth were included in the study. A xerostomia-related quality of life questionnaire, visual analogue scale questionnaire for subjective assessment of salivary dysfunction and salivary flow were reported before and 15 days after the use of topical products based on olive oil, betaina and xylitol.
  
  
  RESULTS
  The four primary quality of life areas demonstrated significantly greater improvement after the use of topical products and all eight VAS items had favourable changes. The reduction of symptoms was statistically significant in 7 of the 8 items. After the use of the products, there were improvements in salivary flow in 45%.
  
  
  CONCLUSIONS
  The use of products based on olive oil, betaine and xylitol, shaped like collutory, toothpaste, gel and spray significantly improved most symptoms and the quality of life limitations produced by dry mouth in patients treated with radiotherapy.
authors.affiliation: Department of Radiation Oncology, Instituto de Investigación Hospital de La Princesa, Diego de León 62, 28006 Madrid, Spain.
authors.forename: Margarita
authors.initials: M
authors.lastname: Martín
authors.affiliation: Department of Radiation Oncology, Instituto de Investigación Hospital de La Princesa, Diego de León 62, 28006 Madrid, Spain.
authors.forename: Alicia
authors.initials: A
authors.lastname: Marín
authors.affiliation: Department of Radiation Oncology, Instituto de Investigación Hospital de La Princesa, Diego de León 62, 28006 Madrid, Spain.
authors.forename: Mario
authors.initials: M
authors.lastname: López
authors.affiliation: Department of Radiation Oncology, Instituto de Investigación Hospital de La Princesa, Diego de León 62, 28006 Madrid, Spain.
authors.forename: Olga
authors.initials: O
authors.lastname: Liñán
authors.affiliation: Department of Radiation Oncology, Instituto de Investigación Hospital de La Princesa, Diego de León 62, 28006 Madrid, Spain.
authors.forename: Felipe
authors.initials: F
authors.lastname: Alvarenga
authors.affiliation: Department of Radiation Oncology, Instituto de Investigación Hospital de La Princesa, Diego de León 62, 28006 Madrid, Spain.
authors.forename: David
authors.initials: D
authors.lastname: Büchser
authors.affiliation: Department of Radiation Oncology, Instituto de Investigación Hospital de La Princesa, Diego de León 62, 28006 Madrid, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Cerezo
keywords: Head and neck neoplasms; Quality of life; Questionnaires; Visual analogue scale; Xerostomia