title: Total Synthesis of the Bis-silyl Ether of (+)-15-epi-Aetheramide A.
abstract: Synthesis of the macrolactone depsipeptide aetheramide A was attempted by three different approaches. The first approach to form the macrolactone involving macrolactonization to form the C1-C21 bond and the second approach using a ring-closing metathesis (RCM) strategy to form the C10-C11 olefinic bond failed. The third approach starting from R-mandelic acid, involving the RCM reaction to install the C18-C19 ring junction, was successful in assembling the macrolactone.
authors.affiliation: Department of Organic Chemistry, Indian Institute of Science , Bangalore 560012, India.
authors.forename: Omkar
authors.initials: O
authors.lastname: Revu
authors.affiliation: Department of Organic Chemistry, Indian Institute of Science , Bangalore 560012, India.
authors.forename: Kavirayani R
authors.identifier: 0000-0003-1453-9798
authors.initials: KR
authors.lastname: Prasad
mesh_terms: D047630:Depsipeptides / Q000138:chemical synthesis* / Q000737:chemistry; D004987:Ethers / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation
chemical_list: D047630:Depsipeptides; D004987:Ethers; C574677:aetheramide A