title: TRP channels in calcium homeostasis: from hormonal control to structure-function relationship of TRPV5 and TRPV6.
abstract: Maintaining plasma calcium levels within a narrow range is of vital importance for many physiological functions. Therefore, calcium transport processes in the intestine, bone and kidney are tightly regulated to fine-tune the rate of absorption, storage and excretion. The TRPV5 and TRPV6 calcium channels are viewed as the gatekeepers of epithelial calcium transport. Several calciotropic hormones control the channels at the level of transcription, membrane expression, and function. Recent technological advances have provided the first near-atomic resolution structural models of several TRPV channels, allowing insight into their architecture. While this field is still in its infancy, it has increased our understanding of molecular channel regulation and holds great promise for future structure-function studies of these ion channels. This review will summarize the mechanisms that control the systemic calcium balance, as well as extrapolate structural views to the molecular functioning of TRPV5/6 channels in epithelial calcium transport.
authors.affiliation: Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands.
authors.forename: Mark K C
authors.initials: MKC
authors.lastname: van Goor
authors.affiliation: Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands. Electronic address: joost.hoenderop@radboudumc.nl.
authors.forename: Joost G J
authors.initials: JGJ
authors.lastname: Hoenderop
authors.affiliation: Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands. Electronic address: jenny.vanderwijst@radboudumc.nl.
authors.forename: Jenny
authors.initials: J
authors.lastname: van der Wijst
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002118:Calcium / Q000502:physiology*; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000502:physiology; D006706:Homeostasis; D006801:Humans; D010281:Parathyroid Hormone / Q000502:physiology; D011487:Protein Conformation; D017386:Sequence Homology, Amino Acid; D013329:Structure-Activity Relationship; D050916:TRPV Cation Channels / Q000737:chemistry / Q000502:physiology*; D014807:Vitamin D / Q000502:physiology
chemical_list: D010281:Parathyroid Hormone; D050916:TRPV Cation Channels; D014807:Vitamin D; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D002118:Calcium
keywords: Calcium; Hormones; Structure; TRP channels