title: Angiotensin converting enzyme 2 polymorphisms and postexercise hypotension in hypertensive medicated individuals.
abstract: The renin-angiotensin aldosterone system (RAAS) is associated with diverse physiological responses and adaptations to exercise. The angiotensin converting enzyme (ACE) 2 has vasodilatory effects, which might be associated with the blood pressure (BP) responses to acute exercise. The aim of this study was to investigate the role of ACE2 polymorphisms in postexercise hypotension (PEH). Thirty-four medicated hypertensive (61·3 ± 1·7 years, 76·1 ± 2·7 kg, 160 ± 1·6 cm) men (n = 12) and women (n = 22), participated in a control and a moderate intensity exercise session in a randomized order. After both experimental sessions, they left the laboratory wearing an ambulatory BP device for 24-h monitoring. ACE2 polymorphisms (Int-1 and Int-3) were assessed by polymerase chain reaction. Over the course of 5-h monitoring, we observed a significant reduction in SBP and DBP following exercise in the AA/AG of the Int-1 polymorphism (p-interaction = 0·02 and 0·001, respectively), whereas this could not be found in the individuals homozygous G (p-interaction = 0·76 and 0·51, respectively). With regard to Int-3 polymorphism, individuals AA/AG showed a significant reduction in SBP following exercise (p-interaction <0·0001) but not for DBP (p-interaction = 0·06) whereas GG individuals showed only a significant reduction in DBP following exercise (p-interaction = 0·02). Our results suggest that ACE2 polymorphism could affect PEH; however, larger trials are needed to confirm our findings.
authors.affiliation: Department of Rehabilitation Sciences, Research Group of Cardiovascular Rehabilitation, KU Leuven, Leuven, Belgium.|Research Group of Cardiovascular Response and Exercise, State University of Londrina, Londrina, Brazil.
authors.forename: Karla F
authors.initials: KF
authors.lastname: Goessler
authors.affiliation: Research Group of Cardiovascular Response and Exercise, State University of Londrina, Londrina, Brazil.
authors.forename: Marcos D
authors.initials: MD
authors.lastname: Polito
authors.affiliation: School of Physical Education and Sport, University of Sao Paulo, Sao Paulo, Brazil.
authors.forename: Gloria de F
authors.initials: GF
authors.lastname: Mota
authors.affiliation: School of Physical Education and Sport, University of Sao Paulo, Sao Paulo, Brazil.
authors.forename: Edilamar M
authors.initials: EM
authors.lastname: de Oliveira
authors.affiliation: Department of Rehabilitation Sciences, Research Group of Cardiovascular Rehabilitation, KU Leuven, Leuven, Belgium.
authors.forename: Véronique A
authors.initials: VA
authors.lastname: Cornelissen
mesh_terms: D000368:Aged; D000085962:Angiotensin-Converting Enzyme 2; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects* / Q000235:genetics*; D018660:Blood Pressure Monitoring, Ambulatory; D015444:Exercise; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000188:drug therapy* / Q000235:genetics* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D010641:Phenotype; D011110:Polymorphism, Genetic; D057774:Post-Exercise Hypotension / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology; D013997:Time Factors
chemical_list: D000959:Antihypertensive Agents; D007703:Peptidyl-Dipeptidase A; C000705307:ACE2 protein, human; D000085962:Angiotensin-Converting Enzyme 2
keywords: RAAS polymorphism; aerobic exercise; ambulatory blood pressure; hypertension; renin-angiotensin system; walk exercise