title: Obstacles to Translating Genotype-Phenotype Correlates in Metabolic Disease.
abstract: Type 2 diabetes mellitus is a polygenic disease with a variable phenotype. Many genetic associations have been described; however, understanding their underlying pathophysiological role in Type 2 diabetes mellitus is important for development of future therapeutic targets. Here, we review the physiological mechanisms of diabetes-associated variants that affect glycemia.
authors.affiliation: Department of Endocrinology, Diabetes and Nutrition, Mayo Clinic, Rochester, Minnesota.
authors.forename: Anu
authors.initials: A
authors.lastname: Sharma
authors.affiliation: Department of Endocrinology, Diabetes and Nutrition, Mayo Clinic, Rochester, Minnesota.
authors.forename: Adrian
authors.initials: A
authors.lastname: Vella
mesh_terms: D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D008659:Metabolic Diseases / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology*; D051379:Mice; D010641:Phenotype; D012307:Risk Factors
chemical_list: D007328:Insulin; D005947:Glucose