title: Lung Cancer in Women with a Family History of Cancer: The Spanish Female-specific Database WORLD07.
abstract: The WORLD07 project is a female-specific database to prospectively analyze the characteristics of Spanish women with lung cancer.
  
  
  
  We analyzed and compared lung cancer features in women with and without a family history of cancer/lung cancer.
  
  
  
  Two thousand and sixty women were included: 876 had a family history of cancer (lung cancer, 34%) and 886 did not, with no significant differences between groups, except for smoking status (p=0.036). We found statistically significant correlations between epidermal growth factor receptor (EGFR) mutation and smoking status in patients with a family history of cancer (r=-0.211; p<0.001) and lung cancer (r=-0.176; p<0.001). Longer median overall survival was observed in women with a family history of cancer and lung cancer.
  
  
  
  Among Spanish women with lung cancer, a greater proportion were current smokers in those with a family history of cancer/lung cancer. There was a significant correlation between the presence of EGFR mutation and smoking.
authors.affiliation: Medical Oncology Department, Instituto de Investigación Sanitaria Aragón, Hospital Clinico Universitario Lozano Blesa, Zaragoza, Spain lola.isla@gmail.com.
authors.forename: Dolores
authors.initials: D
authors.lastname: Isla
authors.affiliation: Medical Oncology Department, Hospital Universitario Miguel Servet, Zaragoza, Spain.
authors.forename: Enriqueta
authors.initials: E
authors.lastname: Felip
authors.affiliation: Medical Oncology Department, Hospital Vall d'Hebron, Barcelona, Spain.
authors.forename: Nuria
authors.initials: N
authors.lastname: Viñolas
authors.affiliation: Medical Oncology Department, Hospital Clínic, Barcelona, Spain.
authors.forename: Mariano
authors.initials: M
authors.lastname: Provencio
authors.affiliation: Medical Oncology Department, Hospital Puerta de Hierro, Madrid, Spain.
authors.forename: Margarita
authors.initials: M
authors.lastname: Majem
authors.affiliation: Medical Oncology Department, Hospital Sant Pau, Barcelona, Spain.
authors.forename: Angel
authors.initials: A
authors.lastname: Artal
authors.affiliation: Medical Oncology Department, Hospital Son Llátzer, Palma de Mallorca, Spain.
authors.forename: Isabel
authors.initials: I
authors.lastname: Bover
authors.affiliation: Medical Oncology Department, Hospital de Mararó, Barcelona, Spain.
authors.forename: Pilar
authors.initials: P
authors.lastname: Lianes
authors.affiliation: Medical Oncology Department, Consorcio Hospital Provincial de Castellón, Castellón De La Plana, Spain.
authors.forename: Ramón
authors.initials: R
authors.lastname: DE Las Peñas
authors.affiliation: Medical Oncology Department, Althaia Xarxa Assistencial Universitaria de Manresa, Manresa, Spain.
authors.forename: Silvia
authors.initials: S
authors.lastname: Catot
authors.affiliation: Medical Oncology Department, Hospital La Paz, Madrid, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: DE Castro
authors.affiliation: Medical Oncology Department, Hospital General de Valencia, Valencia, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Blasco
authors.affiliation: Medical Oncology Department, Hospital Son Espases, Palma de Mallorca, Spain.
authors.forename: Josefa
authors.initials: J
authors.lastname: Terrasa
authors.affiliation: Medical Oncology Department, Hospital Clínico San Carlos, Madrid, Spain.
authors.forename: José Luis
authors.initials: JL
authors.lastname: Gonzalez-Larriba
authors.affiliation: Medical Oncology Department, Hospital La Fe, Valencia, Spain.
authors.forename: Oscar
authors.initials: O
authors.lastname: Juan
authors.affiliation: Medical Oncology Department, Fundación Jiménez Díaz, Madrid, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Dómine
authors.affiliation: Medical Oncology Department, Hospital Nuestra Señora de Valme, Sevilla, Spain.
authors.forename: Reyes
authors.initials: R
authors.lastname: Bernabe
authors.affiliation: Medical Oncology Department, Hospital Ramón y Cajal, Madrid, Spain.
authors.forename: Pilar
authors.initials: P
authors.lastname: Garrido
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics*; D018288:Carcinoma, Small Cell / Q000235:genetics*; D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D013030:Spain
chemical_list: D066246:ErbB Receptors
keywords: Cancer; Spanish women; WORLD07 database; epidermal growth factor receptor; family history; lung cancer risk; menopausal status; smoking