title: The Oral Microbiota in Health and Disease: An Overview of Molecular Findings.
abstract: Culture-independent nucleic acid technologies have been extensively applied to the analysis of oral bacterial communities associated with healthy and diseased conditions. These methods have confirmed and substantially expanded the findings from culture studies to reveal the oral microbial inhabitants and candidate pathogens associated with the major oral diseases. Over 1000 bacterial distinct species-level taxa have been identified in the oral cavity and studies using next-generation DNA sequencing approaches indicate that the breadth of bacterial diversity may be even much larger. Nucleic acid technologies have also been helpful in profiling bacterial communities and identifying disease-related patterns. This chapter provides an overview of the diversity and taxonomy of oral bacteria associated with health and disease.
authors.affiliation: Department ofEndodontics, Molecular Microbiology Laboratory, Estácio de Sá University, Rio de Janeiro, Brazil. jf_siqueira@yahoo.com.|Faculty of Dentistry, Estácio de Sá University, Av. Alfredo Baltazar da Silveira, 580/cobertura, Recreio, Rio de Janeiro, RJ, 22790-710, Brazil. jf_siqueira@yahoo.com.
authors.forename: José F
authors.initials: JF
authors.lastname: Siqueira
authors.affiliation: Department ofEndodontics, Molecular Microbiology Laboratory, Estácio de Sá University, Rio de Janeiro, Brazil.
authors.forename: Isabela N
authors.initials: IN
authors.lastname: Rôças
mesh_terms: D000818:Animals; D001419:Bacteria / Q000145:classification / Q000235:genetics; D044822:Biodiversity; D004198:Disease Susceptibility; D054884:Host-Pathogen Interactions; D006801:Humans; D054892:Metagenome; D056186:Metagenomics / Q000379:methods; D064307:Microbiota; D009055:Mouth / Q000382:microbiology*; D009059:Mouth Diseases / Q000382:microbiology; D014076:Tooth Diseases / Q000382:microbiology
keywords: Molecular biology methods; Oral diseases; Oral microbiology; Taxonomy