title: Mean platelet volume is decreased in adults with active lupus disease.
abstract: BACKGROUND
  Only a few biomarkers are available for assessing disease activity in systemic lupus erythematosus (SLE). Mean platelet volume (MPV) has been recently studied as an inflammatory biomarker. It is currently unclear whether MPV may also play a role as a biomarker of disease activity in adult patients with SLE.
  
  
  OBJECTIVE
  We investigated the association between MPV and disease activity in adult patients with SLE.
  
  
  METHODS
  In this retrospective study, we compared two groups of adult patients divided according to disease activity (36 per group). Subjects were age- and gender-matched.
  
  
  RESULTS
  MPV was significantly decreased with respect to those of inactive patients (7.16±1.39 vs. 8.16±1.50, p=0.005). At a cutoff level of 8.32fL, MPV has a sensitivity of 86% and a specificity of 41% for the detection of disease activity. A modest positive correlation was found between MPV and albumin (r=0.407, p=0.001), which in turn is inversely associated with disease activity.
  
  
  CONCLUSIONS
  In summary, MPV is decreased in adult patients with active lupus disease, and positively correlated with albumin, another biomarker of disease activity. Prospective studies are needed to evaluate the prognostic value of this biomarker.
authors.affiliation: Universidad Autónoma de Nuevo León, Hospital Universitario, Departamento de Medicina Interna, Monterrey, Mexico. Electronic address: grdelgadog@gmail.com.
authors.forename: Guillermo
authors.initials: G
authors.lastname: Delgado-García
authors.affiliation: Universidad Autónoma de Nuevo León, Hospital Universitario, Departamento de Medicina Interna, Monterrey, Mexico; Universidad Autónoma de Nuevo León, Hospital Universitario, Servicio de Reumatología, San Nicolás de los Garza, Mexico.
authors.forename: Dionicio Ángel
authors.initials: DÁ
authors.lastname: Galarza-Delgado
authors.affiliation: Universidad Autónoma de Nuevo León, Hospital Universitario, Servicio de Reumatología, San Nicolás de los Garza, Mexico.
authors.forename: Iris
authors.initials: I
authors.lastname: Colunga-Pedraza
authors.affiliation: Universidad Autónoma de Nuevo León, Hospital Universitario, Departamento de Medicina Interna, Monterrey, Mexico.
authors.forename: Omar David
authors.initials: OD
authors.lastname: Borjas-Almaguer
authors.affiliation: Universidad Autónoma de Nuevo León, Hospital Universitario, Departamento de Medicina Interna, Monterrey, Mexico.
authors.forename: Ilse
authors.initials: I
authors.lastname: Mandujano-Cruz
authors.affiliation: Universidad Autónoma de Nuevo León, Hospital Universitario, Departamento de Medicina Interna, Monterrey, Mexico.
authors.forename: Daniel
authors.initials: D
authors.lastname: Benavides-Salgado
authors.affiliation: Universidad Autónoma de Nuevo León, Hospital Universitario, Departamento de Medicina Interna, Monterrey, Mexico.
authors.forename: Rolando Jacob
authors.initials: RJ
authors.lastname: Martínez-Granados
authors.affiliation: Universidad Autónoma de Nuevo León, Hospital Universitario, Departamento de Medicina Interna, Monterrey, Mexico.
authors.forename: Alexandro
authors.initials: A
authors.lastname: Atilano-Díaz
mesh_terms: D000328:Adult; D001792:Blood Platelets / Q000166:cytology*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood*; D063847:Mean Platelet Volume; D015539:Platelet Activation; D011446:Prospective Studies; D012189:Retrospective Studies
keywords: Albumina sérica; Atividade da doença; Biological markers; Disease activity; Inflamação; Inflammation; Lúpus Eritematoso Sistêmico; Marcadores biológicos; Mean platelet volume; Serum albumin; Systemic lupus erythematosus; Volume plaquetário médio