title: Physical Exercise Moderates the Relationship of Apolipoprotein E (APOE) Genotype and Dementia Risk: A Population-Based Study.
abstract: Genetics and lifestyle independently determine dementia risk, but the interaction is unclear. We assessed the interactive relationship of apolipoprotein E (APOE) genotype and physical exercise on dementia risk over a 5-year period in 1,646 older adults from the Canadian Study of Health and Aging who were dementia-free at baseline. Physical exercise moderated the relationship between genotype and dementia (p < 0.01). Specifically, for APOE ɛ4 non-carriers, the odds of developing dementia were higher in non-exercisers than exercisers (OR = 1.98, 95% CI = 1.44, 2.71, p < 0.001), whereas, for APOE ɛ4 carriers, the odds of developing dementia were not significantly different between non-exercisers and exercisers (OR = 0.71, 95% CI = 0.46, 1.31, p = 0.34). Given that most individuals are not at genetic risk, physical exercise may be an effective strategy for preventing dementia.
authors.affiliation: Department of Kinesiology, McMaster University, Hamilton, ON, Canada.
authors.forename: Barbara
authors.initials: B
authors.lastname: Fenesi
authors.affiliation: Department of Kinesiology, McMaster University, Hamilton, ON, Canada.
authors.forename: Hanna
authors.initials: H
authors.lastname: Fang
authors.affiliation: Department of Kinesiology, McMaster University, Hamilton, ON, Canada.
authors.forename: Ana
authors.initials: A
authors.lastname: Kovacevic
authors.affiliation: School of Public Health and Health Systems, University of Waterloo, Waterloo, ON, Canada.
authors.forename: Mark
authors.initials: M
authors.lastname: Oremus
authors.affiliation: Health Research Methods, Evidence, and Impact (HE&I), McMaster University, Hamilton, ON, Canada.|McMaster Institute for Research on Aging, McMaster University, Hamilton, ON, Canada.|Labarge Centre for Mobility in Aging, McMaster University, Hamilton, ON, Canada.
authors.forename: Parminder
authors.initials: P
authors.lastname: Raina
authors.affiliation: Department of Kinesiology, McMaster University, Hamilton, ON, Canada.|McMaster Institute for Research on Aging, McMaster University, Hamilton, ON, Canada.|Labarge Centre for Mobility in Aging, McMaster University, Hamilton, ON, Canada.
authors.forename: Jennifer J
authors.initials: JJ
authors.lastname: Heisz
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001057:Apolipoproteins E / Q000235:genetics*; D002170:Canada; D018672:Community Health Planning; D003704:Dementia / Q000235:genetics* / Q000503:physiopathology*; D015444:Exercise / Q000502:physiology*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male
chemical_list: D001057:Apolipoproteins E
keywords: Alzheimer’s disease; apolipoprotein E4; dementia; exercise; physical activity; prevention