title: An Amphiphilic Ruthenium Polymetallodrug for Combined Photodynamic Therapy and Photochemotherapy In Vivo.
abstract: An amphiphilic Ru-containing block copolymer is used as a photoactivated polymetallodrug for anticancer phototherapy. The block copolymer self-assembles into nanoparticles, which can accumulate at tumor sites in a mouse model. Red light irradiation of the block copolymer nanoparticles releases anticancer Ru complexes and generates cytotoxic1O2, both of which can inhibit tumor growth.
authors.affiliation: Max Planck Institute for Polymer Research, Ackermannweg 10, 55128, Mainz, Germany.
authors.forename: Wen
authors.initials: W
authors.lastname: Sun
authors.affiliation: Chinese Academy of Sciences (CAS) Center for Excellence in Nanoscience and CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Chinese Academy of Sciences, 100190, Beijing, China.
authors.forename: Shuyi
authors.initials: S
authors.lastname: Li
authors.affiliation: Laboratory of Organic and Macromolecular Chemistry (IOMC), Jena Center for Soft Matter (JCSM), Friedrich Schiller University Jena, Humboldtstr. 10, 07743, Jena, Germany.
authors.forename: Bernhard
authors.initials: B
authors.lastname: Häupler
authors.affiliation: Chinese Academy of Sciences (CAS) Center for Excellence in Nanoscience and CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Chinese Academy of Sciences, 100190, Beijing, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Liu
authors.affiliation: Chinese Academy of Sciences (CAS) Center for Excellence in Nanoscience and CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Chinese Academy of Sciences, 100190, Beijing, China.
authors.forename: Shubin
authors.initials: S
authors.lastname: Jin
authors.affiliation: Max Planck Institute for Polymer Research, Ackermannweg 10, 55128, Mainz, Germany.
authors.forename: Werner
authors.initials: W
authors.lastname: Steffen
authors.affiliation: Laboratory of Organic and Macromolecular Chemistry (IOMC), Jena Center for Soft Matter (JCSM), Friedrich Schiller University Jena, Humboldtstr. 10, 07743, Jena, Germany.
authors.forename: Ulrich S
authors.initials: US
authors.lastname: Schubert
authors.affiliation: Max Planck Institute for Polymer Research, Ackermannweg 10, 55128, Mainz, Germany.
authors.forename: Hans-Jürgen
authors.initials: HJ
authors.lastname: Butt
authors.affiliation: Chinese Academy of Sciences (CAS) Center for Excellence in Nanoscience and CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Chinese Academy of Sciences, 100190, Beijing, China.
authors.forename: Xing-Jie
authors.initials: XJ
authors.lastname: Liang
authors.affiliation: Max Planck Institute for Polymer Research, Ackermannweg 10, 55128, Mainz, Germany.
authors.forename: Si
authors.initials: S
authors.lastname: Wu
mesh_terms: D000818:Animals; D008027:Light; D051379:Mice; D009369:Neoplasms; D010778:Photochemotherapy; D017319:Photosensitizing Agents; D010789:Phototherapy; D012428:Ruthenium / Q000737:chemistry*
chemical_list: D017319:Photosensitizing Agents; D012428:Ruthenium
keywords: metallodrugs; photochemotherapy; photodynamic therapy; polymers; ruthenium