title: Treatment of soft tissue sarcoma: a focus on earlier stages.
abstract: Surgery, with or without radiation therapy, is the standard of care for primary soft tissue sarcoma, with adjuvant/neodjuvant chemotherapy playing a role only in high-risk patients. Chemotherapy is generally the principal treatment modality for locally advanced or metastatic disease. Within this context, newer techniques and promising new treatments are challenging traditional treatment paradigms. For example, identification of histology-specific treatments is leading the field toward individualized care, with better outcomes. Patients over 65 years represent a sizable and largely undertreated sector of the soft tissue sarcoma population, with many being unsuited to receive anthracycline- or ifosfamide-based chemotherapy. First-line treatment options in this population are discussed.
authors.affiliation: Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Gronchi
authors.affiliation: Monter Cancer Center, Northwell Health, & Cold Spring Harbor Laboratory, New Hyde Park, NY, USA.
authors.forename: Robert G
authors.initials: RG
authors.lastname: Maki
authors.affiliation: Sarcoma Unit, Royal Marsden Hospital & Institute of Cancer Research, London, UK.
authors.forename: Robin L
authors.initials: RL
authors.lastname: Jones
mesh_terms: D003131:Combined Modality Therapy / Q000009:adverse effects / Q000379:methods; D019468:Disease Management; D006801:Humans; D009367:Neoplasm Staging; D019233:Retreatment; D012509:Sarcoma / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy*; D016896:Treatment Outcome
keywords: elderly; soft tissue sarcoma; surgical management; trabectedin