title: Serotypes, antimicrobial resistance and genotypes of Streptococcus pneumoniae associated with infections in cancer patients in Brazil.
abstract: We sought to characterize pneumococcal isolates associated with bacteremia, pneumonia and meningitis in cancer patients and to estimate the coverage of the available pneumococcal vaccines. Fifty isolates recovered from 49 patients attending a cancer reference center over a 1-year period were analyzed. The prevalent serotypes were: 23F (12%), 6A (8%), 3, 4, 20, and 23A (6% each). All isolates were susceptible to chloramphenicol, levofloxacin, rifampicin, and vancomycin. Resistance or reduced susceptibility to penicillin made up 14%, and one isolate was also intermediately resistant to ceftriaxone. The three (6%) erythromycin-resistant isolates presented the M or cMLSBphenotypes and harbored the mef(A/E) gene exclusively or along with the erm(B) gene. Twenty-two (44%) isolates were closely related to 11 international clones, being strongly associated with penicillin non-susceptibility. Combined immunization with the 13-valent conjugate and the 23-valent polysaccharide vaccines might contribute to reduce (76%) the burden of the pneumococcal infections in the population investigated.
authors.affiliation: Instituto Biomédico, Universidade Federal Fluminense, Departamento de Microbiologia e Parasitologia, Rua Professor Hernani Melo, 101, São Domingos, Niterói, RJ, Brazil. 24210-130. Electronic address: nay.torresbio@gmail.com.
authors.forename: Nayara Torres
authors.initials: NT
authors.lastname: Cardoso
authors.affiliation: Instituto Biomédico, Universidade Federal Fluminense, Departamento de Microbiologia e Parasitologia, Rua Professor Hernani Melo, 101, São Domingos, Niterói, RJ, Brazil. 24210-130. Electronic address: barbara.araujo1989@bol.com.br.
authors.forename: Bárbara Araújo
authors.initials: BA
authors.lastname: Santos
authors.affiliation: Instituto Biomédico, Universidade Federal Fluminense, Departamento de Microbiologia e Parasitologia, Rua Professor Hernani Melo, 101, São Domingos, Niterói, RJ, Brazil. 24210-130. Electronic address: andre_ctbp@yahoo.com.br.
authors.forename: André Victor
authors.initials: AV
authors.lastname: Barbosa
authors.affiliation: Instituto Nacional de Câncer, Praça Cruz Vermelha, 23, Centro, Rio de Janeiro, RJ, Brazil. 20230-130. Electronic address: nanasuperti@gmail.com.
authors.forename: Silvana Vargas
authors.initials: SV
authors.lastname: Superti
authors.affiliation: Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Departamento de Microbiologia Médica, Avenida Carlos Chagas Filho, 373 - bloco I, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, Brazil, 21941-902. Electronic address: lmt2@micro.ufrj.br.
authors.forename: Lúcia Martins
authors.initials: LM
authors.lastname: Teixeira
authors.affiliation: Instituto Biomédico, Universidade Federal Fluminense, Departamento de Microbiologia e Parasitologia, Rua Professor Hernani Melo, 101, São Domingos, Niterói, RJ, Brazil. 24210-130. Electronic address: fpgneves@vm.uff.br.
authors.forename: Felipe Piedade Gonçalves
authors.initials: FP
authors.lastname: Neves
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D016470:Bacteremia / Q000188:drug therapy / Q000382:microbiology; D001938:Brazil; D002648:Child; D002675:Child, Preschool; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D016920:Meningitis, Bacterial / Q000188:drug therapy / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009369:Neoplasms / Q000382:microbiology; D011008:Pneumococcal Infections / Q000188:drug therapy*; D022242:Pneumococcal Vaccines / Q000276:immunology*; D011014:Pneumonia / Q000188:drug therapy / Q000382:microbiology; D065288:Serogroup; D013296:Streptococcus pneumoniae / Q000145:classification / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification; D055815:Young Adult
chemical_list: C538862:13-valent pneumococcal vaccine; C414006:23-valent pneumococcal capsular polysaccharide vaccine; D000900:Anti-Bacterial Agents; D022242:Pneumococcal Vaccines
keywords: Antimicrobial resistance; Cancer patients; MLST; Pneumococcal diseases; Serotypes; Streptococcus pneumoniae