title: Comparison of Cerebrospinal Fluid Opening Pressure in Children With Demyelinating Disease to Children With Primary Intracranial Hypertension.
abstract: The authors aimed to compare the opening pressures of children with demyelinating disease to children with primary intracranial hypertension. Medical records were reviewed for a primary diagnosis of demyelinating disease, or primary intracranial hypertension. Diagnosis of demyelinating disease was made according to either the 2007 or 2012 International Pediatric Multiple Sclerosis Study Group criteria. Primary intracranial hypertension diagnosis was confirmed by presence of elevated opening pressure, normal cerebrospinal fluid composition and neuroimaging. The authors compared 14 children with demyelinating disease to children with primary intracranial hypertension in 1:1 and 1:2 fashions. There was a statistically significant higher BMI in the primary intracranial hypertension group compared to the demyelinating group ( P = .0203). The mean cerebrospinal fluid white blood cell count was higher in the demyelinating disease group compared to primary intracranial hypertension ( P = .0002). Among both comparisons, the cerebrospinal fluid opening pressure, glucose, protein and red blood cell counts in children with demyelinating disease were comparable to age- and sex-matched controls with primary intracranial hypertension.
authors.affiliation: 1 Department of Neurology, Nationwide Children's Hospital, Columbus, OH, USA.
authors.forename: Bethanie
authors.initials: B
authors.lastname: Morgan-Followell
authors.affiliation: 1 Department of Neurology, Nationwide Children's Hospital, Columbus, OH, USA.
authors.forename: Shawn C
authors.initials: SC
authors.lastname: Aylward
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000134:cerebrospinal fluid; D015992:Body Mass Index; D015170:Cerebrospinal Fluid Pressure; D002648:Child; D003711:Demyelinating Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D006801:Humans; D019586:Intracranial Hypertension / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008297:Male; D059906:Neuroimaging; D012189:Retrospective Studies; D013129:Spinal Puncture; D055815:Young Adult
chemical_list: D015415:Biomarkers
keywords: acute disseminated encephalomyelitis; intracranial hypertension; multiple sclerosis; optic neuritis; pediatric; pseudotumor cerebri; transverse myelitis