title: Neuroprotective Effect of Antioxidants and Moderate Hypoxia as Combined Preconditioning in Cerebral Ischemia.
abstract: We studied combined effect of moderate hypoxia and compounds pQ-4, pQ-915, pQ-1032, and pQ-1104 on neurological deficit and survival of rats after bilateral ligation of common carotid arteries. Preconditioning including moderate hypoxia and treatment with compound pQ-4 produced a neuroprotective effect and increased animal survival during the early (by 51%) and late (by 33.5%) periods of modeled ischemia and reduced neurological deficit (by 50% and 41%, respectively). Moreover, this combination of preconditioning factors prevented postischemic excessive activation of free radical oxidation in brain hemispheres and blood serum.
authors.affiliation: Department of Pharmacology, Smolensk State Medical University, Smolensk, Russia. os.levchenkova@gmail.com.
authors.forename: O S
authors.initials: OS
authors.lastname: Levchenkova
authors.affiliation: Department of Pharmacology, Smolensk State Medical University, Smolensk, Russia.
authors.forename: V E
authors.initials: VE
authors.lastname: Novikov
authors.affiliation: Department of Pharmacology, Smolensk State Medical University, Smolensk, Russia.
authors.forename: E A
authors.initials: EA
authors.lastname: Parfenov
authors.affiliation: Department of Pharmacology, Smolensk State Medical University, Smolensk, Russia.
authors.forename: K N
authors.initials: KN
authors.lastname: Kulagin
mesh_terms: D000111:Acetylcysteine / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002339:Carotid Arteries / Q000601:surgery; D054022:Cerebrum / Q000098:blood supply / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D003131:Combined Modality Therapy; D003374:Coumarins / Q000494:pharmacology; D005260:Female; D000860:Hypoxia / Q000378:metabolism*; D020925:Hypoxia-Ischemia, Brain / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D019194:Ischemic Preconditioning / Q000379:methods*; D008026:Ligation; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology*; D009539:Nicotinic Acids / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D014468:Umbelliferones / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D003374:Coumarins; D018696:Neuroprotective Agents; D009539:Nicotinic Acids; D014468:Umbelliferones; D000111:Acetylcysteine
keywords: cerebral ischemia; neuroprotection; physiologically compatible antioxidants; preconditioning