title: Ulcerative Colitis and Crohn's Disease Are Associated with Decreased Serum Selenium Concentrations and Increased Cardiovascular Risk.
abstract: The incidence of inflammatory bowel disease (IBD) and associated oxidative stress is increasing. The antioxidant mineral selenium (Se) was measured in serum samples from 106 IBD patients (53 with ulcerative colitis (UC) and 53 with Crohn's disease (CD)) and from 30 healthy controls. Serum Se concentrations were significantly lower in UC and CD patients than in healthy controls (p< 0.001) and significantly lower in CD patients than in UC patients (p= 0.006). Se concentrations in patients were significantly influenced by sex, body mass index (BMI), the inflammatory biomarker α-1-antitrypsin, surgery, medical treatment, the severity, extent, and form of the disease and the length of time since onset (p< 0.05). Se concentrations in IBD patients were positively and linearly correlated with nutritional (protein, albumin, prealbumin, cholinesterase and total cholesterol) and iron status-related (hemoglobin, Fe and hematocrit) parameters (p< 0.05). A greater impairment of serum Se and cardiovascular status was observed in CD than in UC patients. An adequate nutritional Se status is important in IBD patients to minimize the cardiovascular risk associated with increased inflammation biomarkers, especially in undernourished CD patients, and is also related to an improved nutritional and body iron status.
authors.affiliation: Digestive Department, Hospital of Jerez de la Frontera, Cádiz E-11403, Spain. ttablada@hotmail.com.|Department of Nutrition and Food Chemistry, Faculty of Pharmacy, University of Granada, Granada E-18071, Spain. ttablada@hotmail.com.
authors.forename: Teresa
authors.initials: T
authors.lastname: Castro Aguilar-Tablada
authors.affiliation: Department of Nutrition and Food Chemistry, Faculty of Pharmacy, University of Granada, Granada E-18071, Spain. nalarcon@ugr.es.
authors.forename: Miguel
authors.initials: M
authors.lastname: Navarro-Alarcón
authors.affiliation: Department of Nutrition and Food Chemistry, Faculty of Pharmacy, University of Granada, Granada E-18071, Spain. quesadag@ugr.es.
authors.forename: Javier
authors.initials: J
authors.lastname: Quesada Granados
authors.affiliation: Department of Nutrition and Food Chemistry, Faculty of Pharmacy, University of Granada, Granada E-18071, Spain. csama@ugr.es.
authors.forename: Cristina
authors.initials: C
authors.lastname: Samaniego Sánchez
authors.affiliation: Department of Nutrition and Food Chemistry, Faculty of Pharmacy, University of Granada, Granada E-18071, Spain. jarufian@ugr.es.|Instituto de Investigación Biosanitaria (IBS), University of Granada, Granada E-18012, Spain. jarufian@ugr.es.
authors.forename: José Ángel
authors.initials: JÁ
authors.lastname: Rufián-Henares
authors.affiliation: Hepatology Department, Granada Hospital Complex, Granada E-18012, Spain. flornogueras@gmail.com.
authors.forename: Flor
authors.initials: F
authors.lastname: Nogueras-Lopez
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control; D003093:Colitis, Ulcerative / Q000097:blood / Q000150:complications* / Q000503:physiopathology / Q000628:therapy; D003424:Crohn Disease / Q000097:blood / Q000150:complications* / Q000503:physiopathology / Q000628:therapy; D003677:Deficiency Diseases / Q000150:complications / Q000178:diet therapy / Q000503:physiopathology*; D018450:Disease Progression; D005260:Female; D019456:Health Transition; D006769:Hospitals, General; D006801:Humans; D008297:Male; D044342:Malnutrition / Q000150:complications; D009752:Nutritional Status; D009765:Obesity / Q000150:complications; D012306:Risk; D012643:Selenium / Q000097:blood / Q000172:deficiency* / Q000627:therapeutic use; D012720:Severity of Illness Index; D012737:Sex Factors; D013030:Spain / Q000453:epidemiology; D000515:alpha 1-Antitrypsin / Q000097:blood
chemical_list: D015415:Biomarkers; C043392:SERPINA1 protein, human; D000515:alpha 1-Antitrypsin; D012643:Selenium
keywords: Crohn’s disease; influencing factors; nutritional and biochemical markers; selenium; ulcerative colitis