title: Genetic and epigenomic mechanisms of mammalian circadian transcription.
abstract: The mammalian molecular clock comprises a complex network of transcriptional programs that integrates environmental signals with physiological pathways in a tissue-specific manner. Emerging technologies are extending knowledge of basic clock features by uncovering their underlying molecular mechanisms, thus setting the stage for a 'systems' view of the molecular clock. Here we discuss how recent data from genome-wide genetic and epigenetic studies have informed the understanding of clock function. In addition to its importance in human physiology and disease, the clock mechanism provides an ideal model to assess general principles of dynamic transcription regulation in vivo.
authors.affiliation: Division of Endocrinology, Diabetes, and Metabolism; Department of Medicine; Department of Genetics; and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
authors.forename: Romeo
authors.initials: R
authors.lastname: Papazyan
authors.affiliation: Division of Endocrinology, Diabetes, and Metabolism; Department of Medicine; Department of Genetics; and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
authors.forename: Yuxiang
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Division of Endocrinology, Diabetes, and Metabolism; Department of Medicine; Department of Genetics; and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
authors.forename: Mitchell A
authors.initials: MA
authors.lastname: Lazar
mesh_terms: D000818:Animals; D057906:Circadian Clocks; D002940:Circadian Rhythm; D019175:DNA Methylation; D057890:Epigenomics / Q000379:methods; D005786:Gene Expression Regulation; D006657:Histones / Q000235:genetics / Q000378:metabolism; D006801:Humans; D060066:Protein Interaction Maps; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D015533:Transcriptional Activation; D054875:Ubiquitination
chemical_list: D006657:Histones; D014157:Transcription Factors