title: Anterior segment imaging-based subdivision of subjects with primary angle-closure glaucoma.
abstract: PurposeThe purpose of this study was to identify whether it was possible to subdivide subjects with primary angle-closure glaucoma (PACG) based on anterior segment optical coherence tomography (ASOCT) imaging, and to determine the characteristics of such subgroups.MethodsWe evaluated 210 subjects with PACG. All subjects underwent gonioscopy and ASOCT imaging. Customized software was used to measure ASOCT parameters. An agglomerative hierarchical clustering method was first used to determine the optimum number of parameters to be included in the determination of subgroups. Then, the best number of subgroups was determined using Akaike Information Criterion (AIC) and Gaussian Mixture Model (GMM) methods.ResultsThe mean age of the subjects was 67.9 years, and 53.3% were female. Following the hierarchical clustering, four parameters (iris area, anterior chamber depth (ACD), anterior chamber width (ACW), and lens vault (LV)) were chosen to be representative of related parameters. The optimal number of subgroups using GMM analysis and AIC was 3. Subgroup 1 (N=89; 42.4%) was characterized by a large iris area, subgroup 2 (N=24; 11.4%) by a large LV and a shallow ACD, whereas subgroup 3 (N=97; 46.2%) displayed only intermediate values across iris area, LV, and ACD.ConclusionsWe identified three distinct subgroups of PACG subjects based on ASOCT imaging.
authors.affiliation: Singapore Eye Research Institute, Singapore, Singapore.|Duke-NUS Graduate Medical School, Singapore, Singapore.
authors.forename: M E
authors.initials: ME
authors.lastname: Nongpiur
authors.affiliation: Singapore Eye Research Institute, Singapore, Singapore.
authors.forename: E
authors.initials: E
authors.lastname: Atalay
authors.affiliation: Bioinformatics Institute, A*STAR (Agency for Science, Technology and Research), Singapore, Singapore.
authors.forename: T
authors.initials: T
authors.lastname: Gong
authors.affiliation: Bioinformatics Institute, A*STAR (Agency for Science, Technology and Research), Singapore, Singapore.
authors.forename: M
authors.initials: M
authors.lastname: Loh
authors.affiliation: Bioinformatics Institute, A*STAR (Agency for Science, Technology and Research), Singapore, Singapore.
authors.forename: H K
authors.initials: HK
authors.lastname: Lee
authors.affiliation: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
authors.forename: M
authors.initials: M
authors.lastname: He
authors.affiliation: Singapore Eye Research Institute, Singapore, Singapore.|Singapore National Eye Centre, Singapore, Singapore.
authors.forename: S A
authors.initials: SA
authors.lastname: Perera
authors.affiliation: Singapore Eye Research Institute, Singapore, Singapore.|Singapore National Eye Centre, Singapore, Singapore.|Yong Loo Lin School of Medicine, Department of Ophthalmology, National University of Singapore, Singapore, Singapore.
authors.forename: T
authors.initials: T
authors.lastname: Aung
mesh_terms: D000368:Aged; D000869:Anterior Eye Segment / Q000473:pathology*; D002681:China; D016000:Cluster Analysis; D005260:Female; D015812:Glaucoma, Angle-Closure / Q000473:pathology*; D006068:Gonioscopy; D006801:Humans; D007429:Intraocular Pressure; D007498:Iris / Q000473:pathology*; D008297:Male; D011446:Prospective Studies; D012984:Software; D041623:Tomography, Optical Coherence