title: The effects of alpha-cypermethrin exposure on biochemical and redox parameters in pregnant rats and their newborns.
abstract: Pyrethroid insecticides are extensively used in agriculture and in household activities. During pregnancy, they might affect maternal metabolic status and there after fetal development. In this work, we studied metabolic and redox effects of low dose alpha-cypermethrin exposure in pregnant rats and their offspring. The diet containing alpha cypermethrin at 0.02mg/kg/day was consumed during the entire gestation. Plasma biochemical parameters as well as liver lipid and oxidative stress markers were determined. Our results showed that alpha-cypermethrin induced an increase in body weight and in plasma glucose and lipid levels, as well as in plasma aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase activities in pregnant rats and their newborns. Pregnant rats showed cellular oxidative stress and altered oxidant-antioxidant status when treated by the insecticide and these disturbances were also seen in their newborns. In conclusion, low dose alpha-cypermethrin exposure induced several metabolic and redox alterations leading to maternal physiological impairments and to fetal metabolic changes. Alpha-cypermethrin should be used with caution especially during pregnancy.
authors.affiliation: Laboratory of Physiology and Biochemistry of Nutrition, Department of Biology, Faculty of Natural and Life Sciences, Earth and Universe, University Abou-Bekr Belkaïd, Tlemcen 13000, Algeria.
authors.forename: Leila
authors.initials: L
authors.lastname: Hocine
authors.affiliation: Laboratory of Physiology and Biochemistry of Nutrition, Department of Biology, Faculty of Natural and Life Sciences, Earth and Universe, University Abou-Bekr Belkaïd, Tlemcen 13000, Algeria. Electronic address: hafidamerzouk_2@hotmail.com.
authors.forename: Hafida
authors.initials: H
authors.lastname: Merzouk
authors.affiliation: Department of Technical Sciences, Faculty of Engineering, University Abou-Bekr Belkaïd, Tlemcen 13000, Algeria.
authors.forename: Sid Ahmed
authors.initials: SA
authors.lastname: Merzouk
authors.affiliation: Laboratory of Physiology and Biochemistry of Nutrition, Department of Biology, Faculty of Natural and Life Sciences, Earth and Universe, University Abou-Bekr Belkaïd, Tlemcen 13000, Algeria.
authors.forename: Hafeda
authors.initials: H
authors.lastname: Ghorzi
authors.affiliation: Laboratory of Physiology and Biochemistry of Nutrition, Department of Biology, Faculty of Natural and Life Sciences, Earth and Universe, University Abou-Bekr Belkaïd, Tlemcen 13000, Algeria.
authors.forename: Meriem
authors.initials: M
authors.lastname: Youbi
authors.affiliation: INSERM UMR 866, "Lipids Nutrition Cancer", University of Burgundy, Faculty of Sciences, 6 Boulevard Gabriel, Dijon 21000, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Narce
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000831:Animals, Newborn; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight / Q000187:drug effects; D005260:Female; D005978:Glutathione / Q000378:metabolism; D007306:Insecticides / Q000633:toxicity*; D008055:Lipids / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008315:Malondialdehyde / Q000378:metabolism; D008431:Maternal-Fetal Exchange; D008659:Metabolic Diseases / Q000097:blood / Q000139:chemically induced* / Q000378:metabolism; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011722:Pyrethrins / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001786:Blood Glucose; D007306:Insecticides; D008055:Lipids; D011722:Pyrethrins; C017160:cypermethrin; D008315:Malondialdehyde; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D005978:Glutathione
keywords: Alpha-cypermethrin; Metabolism; Offspring; Oxidative stress; Pregnancy; Rat