title: Protective effects of Huanglian Wendan Decoction aganist cognitive deficits and neuronal damages in rats with diabetic encephalopathy by inhibiting the release of inflammatory cytokines and repairing insulin signaling pathway in hippocampus.
abstract: Huanglian Wendan decoction (HLWDD) has been used for the treatment of symptom of "Re", one of major causes in diabetes and metabolic disorders, according to the theory of traditional Chinese medicine. The present study aimed at investigating the cerebral protective effects of HLWDD on diabetic encephalopathy (DE), one of the major diabetic complications. The effects of HLWDD and metformin were analyzed in the streptozocin (STZ) + high-glucose-fat (HGF) diet-induced DE rats by gastric intubation. In the present study, the effects of HLWDD on cognition deficits were investigated after 30-day intervention at two daily dose levels (3 and 6 g·kg-1). To explore the potential mechanisms underlying the effects of HLWDD, we detected the alterations of neuronal damages, inflammatory cytokines, and impaired insulin signaling pathway in hippocampus of the DE rats. Based on our results from the present study, we concluded that the protective effects of HLWDD against the cognitive deficits and neuronal damages through inhibiting the release of inflammatory cytokines and repairing insulin signaling pathway in hippocampus of the DE rats.
authors.affiliation: Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing, 210009, China.
authors.forename: Yue-Bi
authors.initials: YB
authors.lastname: Li
authors.affiliation: Department of Basic Medical Sciences, Nanjing University of Traditional Chinese Medicine, Nanjing, 210029, China.
authors.forename: Wei-Hua
authors.initials: WH
authors.lastname: Zhang
authors.affiliation: Department of Basic Medical Sciences, Nanjing University of Traditional Chinese Medicine, Nanjing, 210029, China.
authors.forename: Hua-Dong
authors.initials: HD
authors.lastname: Liu
authors.affiliation: Department of Basic Medical Sciences, Nanjing University of Traditional Chinese Medicine, Nanjing, 210029, China.
authors.forename: Zhou
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing, 210009, China. Electronic address: spm435@163.com.
authors.forename: Shi-Ping
authors.initials: SP
authors.lastname: Ma
mesh_terms: D000818:Animals; D003072:Cognition Disorders / Q000235:genetics / Q000378:metabolism / Q000517:prevention & control*; D016207:Cytokines / Q000235:genetics / Q000378:metabolism*; D003929:Diabetic Neuropathies / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism / Q000523:psychology*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D016207:Cytokines; D004365:Drugs, Chinese Herbal; D007328:Insulin
keywords: Cognition; Diabetic encephalopathy; Huanglian Wendan decoction; Insulin signaling pathway