title: Molecular engineering of a therapeutic antibody for Blo t 5-induced allergic asthma.
authors.affiliation: Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore; Department of Microbiology & Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; NUS Graduate School for Integrative Sciences and Engineering (NGS), National University of Singapore, Singapore.
authors.forename: J H Sherlynn
authors.initials: JHS
authors.lastname: Chan
authors.affiliation: Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore; Department of Microbiology & Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
authors.forename: Yen Leong
authors.initials: YL
authors.lastname: Chua
authors.affiliation: Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore; Department of Pharmacology, Yong Loo Lin School of Medicine, National University Health System, Singapore.
authors.forename: Hong Yong
authors.initials: HY
authors.lastname: Peh
authors.affiliation: Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore.
authors.forename: Vojislav
authors.initials: V
authors.lastname: Jovanovic
authors.affiliation: Department of Microbiology & Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
authors.forename: Nicholas R J
authors.initials: NRJ
authors.lastname: Gascoigne
authors.affiliation: Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore; Department of Pharmacology, Yong Loo Lin School of Medicine, National University Health System, Singapore.
authors.forename: W S Fred
authors.initials: WSF
authors.lastname: Wong
authors.affiliation: Department of Biological Sciences, National University of Singapore, Singapore.
authors.forename: Fook Tim
authors.initials: FT
authors.lastname: Chew
authors.affiliation: Defence Medical and Environmental Research Institute, DSO National Laboratories, Singapore.
authors.forename: Brendon J
authors.initials: BJ
authors.lastname: Hanson
authors.affiliation: Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore; Department of Microbiology & Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
authors.forename: David M
authors.initials: DM
authors.lastname: Kemeny
authors.affiliation: Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore; Department of Microbiology & Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; NUS Graduate School for Integrative Sciences and Engineering (NGS), National University of Singapore, Singapore. Electronic address: paul_macary@nuhs.edu.sg.
authors.forename: Paul A
authors.initials: PA
authors.lastname: MacAry
mesh_terms: D000485:Allergens / Q000276:immunology*; D000818:Animals; D000911:Antibodies, Monoclonal / Q000235:genetics* / Q000627:therapeutic use; D057134:Antibodies, Neutralizing / Q000235:genetics* / Q000627:therapeutic use; D001249:Asthma / Q000276:immunology / Q000628:therapy*; D002478:Cells, Cultured; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology / Q000628:therapy*; D007114:Immunization; D016056:Immunodominant Epitopes / Q000276:immunology*; D007073:Immunoglobulin E / Q000378:metabolism; D007074:Immunoglobulin G / Q000235:genetics*; D051379:Mice; D008810:Mice, Inbred C57BL; D008925:Mites / Q000276:immunology; D008958:Models, Molecular; D019151:Peptide Library; D015202:Protein Engineering / Q000379:methods*
chemical_list: D000485:Allergens; D000911:Antibodies, Monoclonal; D057134:Antibodies, Neutralizing; D016056:Immunodominant Epitopes; D007074:Immunoglobulin G; D019151:Peptide Library; C094701:allergen Blo t 5; D007073:Immunoglobulin E