title: A Novel Method for Estimating Myocardial Strain: Assessment of Deformation Tracking Against Reference Magnetic Resonance Methods in Healthy Volunteers.
abstract: We developed a novel method for tracking myocardial deformation using cardiac magnetic resonance (CMR) cine imaging. We hypothesised that circumferential strain using deformation-tracking has comparable diagnostic performance to a validated method (Displacement Encoding with Stimulated Echoes- DENSE) and potentially diagnostically superior to an established cine-strain method (feature-tracking). 81 healthy adults (44.6 ± 17.7 years old, 47% male), without any history of cardiovascular disease, underwent CMR at 1.5 T including cine, DENSE, and late gadolinium enhancement in subjects >45 years. Acquisitions were divided into 6 segments, and global and segmental peak circumferential strain were derived and analysed by age and sex. Peak circumferential strain differed between the 3 groups (DENSE: -19.4 ± 4.8%; deformation-tracking: -16.8 ± 2.4%; feature-tracking: -28.7 ± 4.8%) (ANOVA with Tukey post-hoc, F-value 279.93, p < 0.01). DENSE and deformation-tracking had better reproducibility than feature-tracking. Intra-class correlation co-efficient was >0.90. Larger magnitudes of strain were detected in women using deformation-tracking and DENSE, but not feature-tracking. Compared with a reference method (DENSE), deformation-tracking using cine imaging has similar diagnostic performance for circumferential strain assessment in healthy individuals. Deformation-tracking could potentially obviate the need for bespoke strain sequences, reducing scanning time and is more reproducible than feature-tracking.
authors.affiliation: BHF Glasgow Cardiovascular Research Centre, University of Glasgow, UK.|West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Clydebank, UK.
authors.forename: Kenneth
authors.initials: K
authors.lastname: Mangion
authors.affiliation: School of Mathematics and Statistics, University of Glasgow, UK.
authors.forename: Hao
authors.initials: H
authors.lastname: Gao
authors.affiliation: BHF Glasgow Cardiovascular Research Centre, University of Glasgow, UK.|Clinical Physics, NHS Greater Glasgow and Clyde, Glasgow, UK.
authors.forename: Christie
authors.initials: C
authors.lastname: McComb
authors.affiliation: West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Clydebank, UK.
authors.forename: David
authors.initials: D
authors.lastname: Carrick
authors.affiliation: BHF Glasgow Cardiovascular Research Centre, University of Glasgow, UK.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Clerfond
authors.affiliation: MR R&D Collaborations, Siemens Healthcare, Atlanta, GA, USA.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Zhong
authors.affiliation: School of Mathematics and Statistics, University of Glasgow, UK.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Luo
authors.affiliation: Robertson Centre for Biostatistics, University of Glasgow, UK.
authors.forename: Caroline E
authors.initials: CE
authors.lastname: Haig
authors.affiliation: BHF Glasgow Cardiovascular Research Centre, University of Glasgow, UK.|West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Clydebank, UK.
authors.forename: Colin
authors.initials: C
authors.lastname: Berry
mesh_terms: D000328:Adult; D003287:Contrast Media; D005260:Female; D005682:Gadolinium; D006321:Heart / Q000033:anatomy & histology* / Q000502:physiology; D006334:Heart Function Tests / Q000379:methods*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D009206:Myocardium; D009929:Organ Size; D012015:Reference Standards; D013314:Stress, Mechanical; D013997:Time Factors; D016277:Ventricular Function, Left / Q000502:physiology*; D055815:Young Adult
chemical_list: D003287:Contrast Media; D005682:Gadolinium