title: Targeting Interleukin-2-Inducible T-cell Kinase (ITK) in T-Cell Related Diseases.
abstract: IL2-inducible T-cell kinase (ITK), a member of the Tec family tyrosine kinases, is the predominant Tec kinase in T cells and natural killer (NK) cells mediating T cell receptor (TCR) and Fc receptor (Fc R) initiated signal transduction. ITK deficiency results in impaired T and NK cell functions, leading to various disorders including malignancies, inflammation, and autoimmune diseases. In this mini-review, the role of ITK in T cell signaling and the development of small molecule inhibitors of ITK for the treatment of T-cell related disorders is examined.
authors.affiliation: Division of Hematology, Department of Internal Medicine, The Ohio State University, 320 W. 10th Avenue, Columbus, OH 43210, USA.
authors.forename: Yiming
authors.initials: Y
authors.lastname: Zhong
authors.affiliation: Division of Hematology, Department of Internal Medicine, The Ohio State University, 320 W. 10th Avenue, Columbus, OH 43210, USA.
authors.forename: Amy J
authors.initials: AJ
authors.lastname: Johnson
authors.affiliation: Division of Hematology, Department of Internal Medicine, The Ohio State University, 320 W. 10th Avenue, Columbus, OH 43210, USA.
authors.forename: John C
authors.initials: JC
authors.lastname: Byrd
authors.affiliation: Division of Hematology, Department of Internal Medicine, The Ohio State University, 320 W. 10th Avenue, Columbus, OH 43210, USA.
authors.forename: Jason A
authors.initials: JA
authors.lastname: Dubovsky
keywords: IL2-inducible T-cell kinase (ITK); T cell signaling; inhibitors of ITK