title: Effects of passiflora incarnata and midazolam for control of anxiety in patients undergoing dental extraction.
abstract: BACKGROUND
  Anxiety symptoms are frequently observed in dental patients, whether they are undergoing simple or more invasive procedures such as surgery. This research aimed to compare the effects of Passiflora incarnata and midazolam for the control of anxiety in patients undergoing mandibular third molar extraction.
  
  
  METHODS
  Forty volunteers underwent bilateral extraction of their mandibular third molars in a randomized, controlled, double-blind, crossover clinical trial. Passiflora incarnata (260 mg) or midazolam (15 mg) were orally administered 30 minutes before surgery. The anxiety level of participants was evaluated by questionnaires and measurement of physical parameters, including heart rate (HR), blood pressure (BP), and oxygen saturation (SpO2).
  
  
  RESULTS
  Considering each procedure independently, there were no significant differences between the protocols in BP, HR, and SpO2. Over 70% of the volunteers responded that they felt quiet or a little anxious under both protocols. With midazolam, 20% of the participants reported amnesia (not remembering anything at all), while Passiflora showed little or no ability to interfere with memory formation.
  
  
  CONCLUSIONS
  Passiflora incarnata showed an anxiolytic effect similar to midazolam, and was safe and effective for conscious sedation in adult patients who underwent extraction of their mandibular third molars.
authors.affiliation: Av. Ministro Geraldo Barreto Sobral, n 2100, JFC Trade Center, Sala 1408 - Jardins, Aracaju/SE, CEP: 49026-010, Brasil, lilipocon@hotmail.com.
authors.forename: L-P
authors.initials: LP
authors.lastname: Dantas
authors.forename: A
authors.initials: A
authors.lastname: de Oliveira-Ribeiro
authors.forename: L-M
authors.initials: LM
authors.lastname: de Almeida-Souza
authors.forename: F-C
authors.initials: FC
authors.lastname: Groppo
mesh_terms: D014151:Anti-Anxiety Agents / Q000627:therapeutic use*; D018592:Cross-Over Studies; D016854:Dental Anxiety / Q000517:prevention & control*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008874:Midazolam / Q000627:therapeutic use*; D008964:Molar, Third / Q000601:surgery*; D029598:Passiflora; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D014081:Tooth Extraction; D055815:Young Adult
chemical_list: D014151:Anti-Anxiety Agents; D010936:Plant Extracts; D008874:Midazolam