title: Evidence on methylphenidate in children and adolescents with ADHD is in fact of 'very low quality'.
abstract: Banaschewski and colleagues from the European Attention Deficit Hyperactivity Disorder (ADHD) guideline group make a number of critical comments regarding our systematic review on methylphenidate for children and adolescents with ADHD. In this article, we present our views, showing that our trial selection was not flawed and was undertaken with scientific justification. Similarly, our data collection and interpretation was systematic and correct. We have followed a sound methodology for assessing risk of bias and our conclusions are not misleading. We acknowledge that different researchers might make risk of bias judgments at higher or lower thresholds, but we have been consistent and transparent in applying our pre-defined and per reviewed protocol. Although we made minor errors, we demonstrate that the effects are negligible and not affecting our conclusions. We are happy to correct such errors and to engage in debate on methodological and ethical issues. In terms of clinical implications, we are advocating that clinicians, patients and their relatives should weight carefully risks and benefits of methylphenidate. Clinical experience seems to suggest that there are people who benefit from this medication. Our systematic review does, however, raise questions regarding the overall quality of the methylphenidate trials.
authors.affiliation: Psychiatric Research Unit, Region Zealand Psychiatry, Slagelse, Denmark.|Child and Adolescent Psychiatric Department, Region Zealand, Roskilde, Denmark.|Department of Psychology, Faculty of Health Science, University of Southern Denmark, Denmark.
authors.forename: O J
authors.identifier: 0000-0003-0204-7745
authors.initials: OJ
authors.lastname: Storebø
authors.affiliation: Whittington Health, Islington CAMHS, London, UK.
authors.forename: M
authors.initials: M
authors.lastname: Zwi
authors.affiliation: Psychiatric Research Unit, Region Zealand Psychiatry, Slagelse, Denmark.|Child and Adolescent Psychiatric Department, Region Zealand, Roskilde, Denmark.
authors.forename: H B
authors.initials: HB
authors.lastname: Krogh
authors.affiliation: Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: C R
authors.initials: CR
authors.lastname: Moreira-Maia
authors.affiliation: Psychiatric Research Unit, Region Zealand Psychiatry, Slagelse, Denmark.|Child and Adolescent Psychiatric Department, Region Zealand, Roskilde, Denmark.
authors.forename: M
authors.initials: M
authors.lastname: Holmskov
authors.affiliation: Mental Health, Western Sydney Local Health District, Parramatta, Australia.
authors.forename: D
authors.initials: D
authors.lastname: Gillies
authors.affiliation: Pediatric Department, Herlev University Hospital, Herlev, Denmark.
authors.forename: C
authors.initials: C
authors.lastname: Groth
authors.affiliation: Psychiatric Research Unit, Region Zealand Psychiatry, Slagelse, Denmark.|Clinical Institute, University of Copenhagen, Copenhagen, Denmark.
authors.forename: E
authors.initials: E
authors.lastname: Simonsen
authors.affiliation: The Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 7812, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.|The Cochrane Hepato-Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
authors.forename: C
authors.initials: C
authors.lastname: Gluud
mesh_terms: D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy*; D002648:Child; D003625:Data Collection; D006801:Humans; D007600:Judgment; D008774:Methylphenidate / Q000627:therapeutic use*; D018570:Risk Assessment
chemical_list: D008774:Methylphenidate