title: Next-Generation Sequencing of Lung Cancers: Lessons Learned and Future Directions.
abstract: Targeted therapies and immune checkpoint inhibitors have significantly improved outcomes in a sizable fraction of patients with metastatic non-small cell lung cancer. Nevertheless, a majority of patients with lung cancer continue to have poor outcomes. The ability to comprehensively characterize the genomic alterations in various subtypes of lung cancer has the potential to transform cancer care by facilitating the identification of novel treatment strategies. The objective of this review is to summarize key findings from recent studies that have sequenced a large number of lung cancer samples and discuss the diagnostic, prognostic, and therapeutic relevance of these findings.
authors.affiliation: Division of Oncology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA.
authors.forename: Siddhartha
authors.initials: S
authors.lastname: Devarakonda
authors.affiliation: Division of Oncology, Alvin J Siteman Cancer Center, Washington University School of Medicine, 660 South Euclid Avenue, Box 8056, St. Louis, MO 63110, USA.
authors.forename: Ashiq
authors.initials: A
authors.lastname: Masood
authors.affiliation: Section of Medical Oncology, Division of Oncology, Alvin J Siteman Cancer Center, Washington University School of Medicine, 660 South Euclid Avenue, Box 8056, St. Louis, MO 63110, USA. Electronic address: rgovindan@wustl.edu.
authors.forename: Ramaswamy
authors.initials: R
authors.lastname: Govindan
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics*; D019496:Cancer Vaccines / Q000235:genetics / Q000627:therapeutic use; D015894:Genome, Human; D059014:High-Throughput Nucleotide Sequencing / Q000379:methods*; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D008175:Lung Neoplasms / Q000235:genetics* / Q000276:immunology / Q000628:therapy; D009154:Mutation
chemical_list: D014408:Biomarkers, Tumor; D019496:Cancer Vaccines
keywords: Lung cancer; Sequencing; Treatment