title: Risk factor profile of calcific aortic stenosis.
abstract: BACKGROUND
  Calcific aortic stenosis and coronary artery disease share common risk factors. In some of the previous studies statins have been used to retard the progression of aortic stenosis, but the results were inconsistent.
  
  
  METHODS
  One hundred and ten patients of CAS above the age of 40 years have undergone clinical, biochemical and echocardiographic evaluation. Coronary angiograms were done in 66% of them.
  
  
  RESULTS
  Male to female ratio was 2:1. Patients of CAS with CAD showed higher prevalence of diabetes, hypertension, dyslipidemia, smoking and family history of CAD. Prevalence of obesity and bicuspid aortic valve by echocardiogram was high in those without CAD.
  
  
  CONCLUSIONS
  On comparison of prevalence of risk factor in those with and without associated CAD, there was higher prevalence of diabetes (65% vs 30%), hypertension (52% vs 43%), dyslipidemia (69% vs 52%), smoking (24% vs 18%) and family history of CAD (34% vs 16%) in those with associated CAD. The incidence of obesity was higher in those without CAD (20% vs 30%). The difference observed in diabetes alone was found to be statistically significant.
authors.affiliation: Department of Cardiology, Apollo Main Hospital, Chennai, India. Electronic address: drismurthy@gmail.com.
authors.forename: I
authors.initials: I
authors.lastname: Sathyamurthy
authors.affiliation: Apollo Main Hospitals, India.
authors.forename: Shaji
authors.initials: S
authors.lastname: Alex
authors.affiliation: Apollo Main Hospital, Chennai, India.
authors.forename: K
authors.initials: K
authors.lastname: Kirubakaran
authors.affiliation: Apollo Main Hospital, Chennai, India.
authors.forename: G
authors.initials: G
authors.lastname: Sengottuvelu
authors.affiliation: Apollo Main Hospital, Chennai, India.
authors.forename: K N
authors.initials: KN
authors.lastname: Srinivasan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001021:Aortic Valve / Q000473:pathology*; D001024:Aortic Valve Stenosis / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D002114:Calcinosis / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007194:India / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D015996:Survival Rate / Q000639:trends
keywords: Atherosclerosis; Coronary artery disease; Degenerative aortic stenosis