title: [Effect of NLRP3 inflammasome on vascular diseases].
abstract: The NLRP3 inflammasome, a protein complex belonging to the family of nucleotide-binding and oligomerization domain like receptors (NLRs), plays a vital role in the innate immune system. It promotes pro-caspase 1 cleavage into active caspase-1, which contributes to maturation and releases of IL-1β and IL-18 in response to the harmful signals and participates in the host immune response and sterile inflammation. Recently a large number of studies have shown that NLRP3 inflammasome closely relates to the pathogenesis of the vascular diseases. NLRP3 inflammasome, which involves in the sterile inflammation of the vascular wall, plays an important role in the pathogenesis of main, middle and small arteries.
authors.affiliation: Department of Cardiology, Third Xiangya Hospital, Central South University; Center for Vascular Disease and Translational Medicine, Central South University.
authors.forename: Zeng
authors.initials: Z
authors.lastname: Cao
authors.affiliation: Department of Cardiology, Third Xiangya Hospital, Central South University;. Center for Vascular Disease and Translational Medicine, Central South University, Changsha 410013, China.
authors.forename: Yapei
authors.initials: Y
authors.lastname: Li
authors.affiliation: Center for Vascular Disease and Translational Medicine, Central South University;. Medicine Experimental Center, Third Xiangya Hospital, Central South University, Changsha 410013, China.
authors.forename: Ruifang
authors.initials: R
authors.lastname: Chen
authors.affiliation: Center for Vascular Disease and Translational Medicine, Central South University;. Medicine Experimental Center, Third Xiangya Hospital, Central South University, Changsha 410013, China.
authors.forename: Pingyu
authors.initials: P
authors.lastname: Zeng
mesh_terms: D020170:Caspase 1 / Q000276:immunology / Q000378:metabolism; D005786:Gene Expression Regulation / Q000235:genetics / Q000276:immunology; D006801:Humans; D058847:Inflammasomes / Q000276:immunology*; D007249:Inflammation / Q000150:complications* / Q000235:genetics*; D020382:Interleukin-18 / Q000235:genetics / Q000276:immunology; D053583:Interleukin-1beta / Q000235:genetics / Q000276:immunology; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein / Q000276:immunology*; D015398:Signal Transduction / Q000235:genetics / Q000276:immunology; D014652:Vascular Diseases / Q000209:etiology* / Q000235:genetics* / Q000276:immunology*
chemical_list: D058847:Inflammasomes; D020382:Interleukin-18; D053583:Interleukin-1beta; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; C453881:NLRP3 protein, human; D020170:Caspase 1