title: Mannose-Binding Lectin Deficiency in Brazilian Patients with Spondyloarthritis.
abstract: BACKGROUND
  Infections are usually involved in the pathogenesis of spondyloarthritis (SpA). Mannose-binding lectin (MBL) is a component of the innate immune system with an important role in microbial defense.
  
  
  OBJECTIVE
  To study the prevalence of MBL deficiency in SpA patients as well as its influence in the clinical profile of these diseases.
  
  
  METHODS
  We studied 89 SpA patients and 89 healthy individuals, paired for age and gender. MBL serum levels were measured by ELISA test. Individuals with levels ≤100 ng/mL were considered deficient. SpA patients had determination of Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Ankylosing Spondylitis Disease Activity Score (ASDAS)-CRP, Bath Ankylosing Spondylitis Functional Index (BASFI), C reactive protein (CRP), erythrocyte sedimentation rate (ESR), and review of their clinical profile.
  
  
  RESULTS
  SpA patients had MBL levels ranging from 100 to 4100 ng/mL (median = 375 ng/mL); controls levels ranged from 100 to 4703 ng/mL (median = 1204 ng/mL; p < 0.0001). The prevalence of MBL deficiency was 27/89 (30.3%) in SpA patients and 12/89 (13.5%) in controls, with p = 0.01; OR = 2.5 (95% IC = 1.2-5.3). No association/correlation was found between MBL levels with BASDAI, BASFI, age at disease onset, ASDAS-CRP, ESR, CRP, presence of uveitis, HLAB27, peripheral arthritis, or SpA subtype (all p = NS).
  
  
  CONCLUSIONS
  MBL levels may be linked with the occurrence of SpA but do not influence its phenotype.
authors.affiliation: a Rheumatology Unit , Evangelical Hospital , Curitiba , Paraná , Brazil.
authors.forename: Thelma L
authors.initials: TL
authors.lastname: Skare
authors.affiliation: a Rheumatology Unit , Evangelical Hospital , Curitiba , Paraná , Brazil.|b Department of Medicine , Positivo University , Curitiba , Paraná , Brazil.
authors.forename: Renato
authors.initials: R
authors.lastname: Nisihara
authors.affiliation: c Department of Clinical Analysis , Federal University of Paraná , Curitiba , Paraná , Brazil.
authors.forename: Juliana Z
authors.initials: JZ
authors.lastname: Cieslinski
authors.affiliation: a Rheumatology Unit , Evangelical Hospital , Curitiba , Paraná , Brazil.
authors.forename: João O
authors.initials: JO
authors.lastname: Zeni
authors.affiliation: a Rheumatology Unit , Evangelical Hospital , Curitiba , Paraná , Brazil.
authors.forename: Henrique N
authors.initials: HN
authors.lastname: Rasera
authors.affiliation: c Department of Clinical Analysis , Federal University of Paraná , Curitiba , Paraná , Brazil.
authors.forename: Iara
authors.initials: I
authors.lastname: Messias-Reason
authors.affiliation: c Department of Clinical Analysis , Federal University of Paraná , Curitiba , Paraná , Brazil.
authors.forename: Shirley R R
authors.initials: SR
authors.lastname: Utiyama
mesh_terms: D000328:Adult; D001799:Blood Sedimentation; D001938:Brazil / Q000453:epidemiology; D002097:C-Reactive Protein / Q000378:metabolism; D003430:Cross-Sectional Studies; D018450:Disease Progression; D005260:Female; D015796:HLA-B27 Antigen / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics; D008297:Male; D037601:Mannose-Binding Lectin / Q000097:blood / Q000172:deficiency* / Q000235:genetics*; D008661:Metabolism, Inborn Errors / Q000453:epidemiology*; D008875:Middle Aged; D010641:Phenotype; D015995:Prevalence; D012720:Severity of Illness Index; D013167:Spondylitis, Ankylosing / Q000453:epidemiology*
chemical_list: D015796:HLA-B27 Antigen; D037601:Mannose-Binding Lectin; D002097:C-Reactive Protein
keywords: Complement; MBL; deficiency; spondyloarthritis