title: Binge ethanol drinking during adolescence modifies cocaine responses in mice.
abstract: Binge ethanol drinking is an emerging pattern of excessive consumption among adolescents and young adults. Repeated ethanol intoxication has negative consequences during critical periods of brain development. Therefore, binge ethanol intake represents a vulnerability factor that promotes subsequent manifestations of neuropsychiatric disorders. In this study, we investigated the effects of oral binge ethanol intake during adolescence on the subsequent effects of cocaine in C57BL/6 mice. Firstly, we evaluated the oral ethanol intake of two binge ethanol procedures with different ethanol concentrations (20% v/v versus 30%, v/v). The highest ethanol intake was found in mice exposed to the lower ethanol concentration (20% v/v). In a second experiment, mice exposed to binge ethanol procedure were evaluated to study the effects of cocaine on locomotor activity, behavioural sensitization, and the reinforcing effects of cocaine in the self-administration paradigm. Mice exposed to ethanol binging showed discrete detrimental effects in responses to cocaine in the different experiments evaluated. Our findings revealed that the pattern of binge ethanol consumption in adolescent mice here evaluated produced a weak facilitation of cocaine responses. The present study highlights the importance of interventions to limit the deleterious effects of binge ethanol drinking during adolescence.
authors.affiliation: 1 Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain.
authors.forename: Anna
authors.initials: A
authors.lastname: Esteve-Arenys
authors.affiliation: 1 Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain.
authors.forename: Irene
authors.initials: I
authors.lastname: Gracia-Rubio
authors.affiliation: 1 Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain.
authors.forename: Lídia
authors.initials: L
authors.lastname: Cantacorps
authors.affiliation: 2 Bioanalysis Research Group, IMIM-Hospital del Mar Medical Research Institute, Barcelona, Spain.
authors.forename: Oscar J
authors.initials: OJ
authors.lastname: Pozo
authors.affiliation: 1 Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain.|2 Bioanalysis Research Group, IMIM-Hospital del Mar Medical Research Institute, Barcelona, Spain.
authors.forename: Josep
authors.initials: J
authors.lastname: Marcos
authors.affiliation: 3 Departamento de Psicobiología, Universidad de Valencia, Valencia, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Rodríguez-Árias
authors.affiliation: 3 Departamento de Psicobiología, Universidad de Valencia, Valencia, Spain.
authors.forename: José
authors.initials: J
authors.lastname: Miñarro
authors.affiliation: 1 Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain.|4 Neuroscience Research Programme, IMIM-Hospital del Mar Research Institute, Barcelona, Spain.
authors.forename: Olga
authors.initials: O
authors.lastname: Valverde
mesh_terms: D000367:Age Factors; D000428:Alcohol Drinking / Q000009:adverse effects*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D063425:Binge Drinking / Q000503:physiopathology*; D003042:Cocaine / Q000494:pharmacology*; D000431:Ethanol / Q000009:adverse effects*; D008124:Locomotion / Q000187:drug effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D012646:Self Administration / Q000379:methods
chemical_list: D000431:Ethanol; D003042:Cocaine
keywords: Cocaine; adolescent mice; behavioural sensitization; binge ethanol drinking; reward