title: Clinical and Molecular Perspectives of Reparative Dentin Formation: Lessons Learned from Pulp-Capping Materials and the Emerging Roles of Calcium.
abstract: The long-term use of calcium hydroxide and the recent increase in the use of hydraulic calcium-silicate cements as direct pulp-capping materials provide important clues in terms of how reparative dentin may be induced to form a "biological seal" to protect the underlying pulp tissues. In this review article, we discuss clinical and molecular perspectives of reparative dentin formation based on evidence learned from the use of these pulp-capping materials. We also discuss the emerging role of calcium as an odontoinductive component in these pulp-capping materials.
authors.affiliation: The Shapiro Family Laboratory of Viral Oncology and Aging Research, UCLA School of Dentistry, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA; Section of Restorative Dentistry, UCLA School of Dentistry, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA.
authors.forename: Minju
authors.initials: M
authors.lastname: Song
authors.affiliation: Section of Restorative Dentistry, UCLA School of Dentistry, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA.
authors.forename: Bo
authors.initials: B
authors.lastname: Yu
authors.affiliation: The Shapiro Family Laboratory of Viral Oncology and Aging Research, UCLA School of Dentistry, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA; Section of Restorative Dentistry, UCLA School of Dentistry, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA.
authors.forename: Sol
authors.initials: S
authors.lastname: Kim
authors.affiliation: Section of Restorative Dentistry, UCLA School of Dentistry, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA.
authors.forename: Marc
authors.initials: M
authors.lastname: Hayashi
authors.affiliation: Section of Restorative Dentistry, UCLA School of Dentistry, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA.
authors.forename: Colby
authors.initials: C
authors.lastname: Smith
authors.affiliation: The Shapiro Family Laboratory of Viral Oncology and Aging Research, UCLA School of Dentistry, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA.
authors.forename: Suhjin
authors.initials: S
authors.lastname: Sohn
authors.affiliation: Microscope Center, Department of Conservative Dentistry, Oral Science Research Center, Yonsei University College of Dentistry, 50 Yonsei-Ro, 03772, Seoul, Korea.
authors.forename: Euiseong
authors.initials: E
authors.lastname: Kim
authors.affiliation: Section of Restorative Dentistry, UCLA School of Dentistry, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA.
authors.forename: James
authors.initials: J
authors.lastname: Lim
authors.affiliation: Section of Restorative Dentistry, UCLA School of Dentistry, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA.
authors.forename: Richard G
authors.initials: RG
authors.lastname: Stevenson
authors.affiliation: The Shapiro Family Laboratory of Viral Oncology and Aging Research, UCLA School of Dentistry, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA; Section of Restorative Dentistry, UCLA School of Dentistry, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA. Electronic address: rkim@dentistry.ucla.edu.
authors.forename: Reuben H
authors.initials: RH
authors.lastname: Kim
mesh_terms: D017607:Aluminum Compounds; D001843:Bone Cements; D017610:Calcium Compounds; D002126:Calcium Hydroxide; D020013:Calcium Signaling / Q000502:physiology*; D003785:Dental Pulp Capping; D003809:Dentin, Secondary; D004338:Drug Combinations; D006801:Humans; D010087:Oxides; D017640:Silicates
chemical_list: D017607:Aluminum Compounds; D001843:Bone Cements; D017610:Calcium Compounds; D004338:Drug Combinations; D010087:Oxides; D017640:Silicates; C086631:mineral trioxide aggregate; D002126:Calcium Hydroxide; C031293:calcium silicate
keywords: Calcium; Calcium hydroxide; Hydraulic calcium-silicate cements; ORAI1; Odontoconductive; Odontoinductive; Reparative dentin