title: Contribution of mammalian selenocysteine-containing proteins to carcinogenesis.
abstract: Oxidative stress caused by a sharp growth of free radicals in the organism is a major cause underlying the occurrence of all kinds of malignant formations. Selenium is an important essential trace element found in selenoproteins in the form of selenocysteine, an amino acid differing from cysteine for the presence of selenium instead of sulfur and making such proteins highly active. To date the role of selenium has been extensively investigated through studying the functions of selenoproteins in carcinogenesis. Analysis of the obtained results clearly demonstrates that selenoproteins can act as oncosuppressors, but can also, on the contrary, favor the formation of malignant tumors.
authors.affiliation: Federal State Institution of Science Institute of Cell Biophysics, Russian Academy of Sciences, Moscow Region, Institutskaya st. 3, 142290, Pushchino, Russia. Electronic address: 1928lv@mail.ru.
authors.forename: Elena Gennadyevna
authors.initials: EG
authors.lastname: Varlamova
authors.affiliation: Federal State Educational Institution of Higher Education Voronezh State University of Engineering Technology, Prospect revolution st. 19, 394000, Voronezh, Russia. Electronic address: irinacher2010@yandex.ru.
authors.forename: Irina Valentinovna
authors.initials: IV
authors.lastname: Cheremushkina
mesh_terms: D000818:Animals; D063646:Carcinogenesis; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism*; D012643:Selenium / Q000378:metabolism; D017279:Selenocysteine / Q000235:genetics / Q000378:metabolism*; D051140:Selenoproteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D051140:Selenoproteins; D017279:Selenocysteine; D012643:Selenium
keywords: Carcinogenesis; Mammalian selenoproteins; Selenium