title: The antiSMASH database, a comprehensive database of microbial secondary metabolite biosynthetic gene clusters.
abstract: Secondary metabolites produced by microorganisms are the main source of bioactive compounds that are in use as antimicrobial and anticancer drugs, fungicides, herbicides and pesticides. In the last decade, the increasing availability of microbial genomes has established genome mining as a very important method for the identification of their biosynthetic gene clusters (BGCs). One of the most popular tools for this task is antiSMASH. However, so far, antiSMASH is limited to de novo computing results for user-submitted genomes and only partially connects these with BGCs from other organisms. Therefore, we developed the antiSMASH database, a simple but highly useful new resource to browse antiSMASH-annotated BGCs in the currently 3907 bacterial genomes in the database and perform advanced search queries combining multiple search criteria. antiSMASH-DB is available at http://antismash-db.secondarymetabolites.org/.
authors.affiliation: The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark.
authors.forename: Kai
authors.initials: K
authors.lastname: Blin
authors.affiliation: Bioinformatics Group, Wageningen University, 6708 PB Wageningen, The Netherlands.
authors.forename: Marnix H
authors.initials: MH
authors.lastname: Medema
authors.affiliation: Microbial Genomics and Bioinformatics Research Group, Max Planck Institute for Marine Microbiology, 28359 Bremen, Germany.
authors.forename: Renzo
authors.initials: R
authors.lastname: Kottmann
authors.affiliation: The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark leesy@kaist.ac.kr.|Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering (BK21 Plus Program), Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.
authors.forename: Sang Yup
authors.initials: SY
authors.lastname: Lee
authors.affiliation: The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark tiwe@biosustain.dtu.dk.
authors.forename: Tilmann
authors.identifier: 0000-0002-8260-5120
authors.initials: T
authors.lastname: Weber
mesh_terms: D053898:Biosynthetic Pathways / Q000235:genetics; D019295:Computational Biology / Q000379:methods; D016208:Databases, Factual; D005786:Gene Expression Regulation; D008829:Microbiology; D011499:Protein Processing, Post-Translational; D064210:Secondary Metabolism / Q000235:genetics; D064878:Web Browser