title: Non-islet cell tumor hypoglycemia caused by a big insulin-like growth factor II- producing hepatocellular carcinoma:an autopsy case report.
abstract: A 73-year-old man with a hepatocellular carcinoma was admitted to our hospital. He suffered from recurrent severe hypoglycemia. An autopsy was performed after his death. Anti-insulin-like growth factor II (IGF-II) monoclonal antibody immunostaining of the hepatocellular carcinoma was positive. Western immunoblot analysis of the serum revealed highly elevated IGF-II. Therefore, we diagnosed this case as a non-islet cell tumor hypoglycemia caused by a big IGF-II-producing hepatocellular carcinoma.
authors.affiliation: Department of Gastroenterology, Hakodate Municipal Hospital.
authors.forename: Hirohito
authors.initials: H
authors.lastname: Naruse
authors.forename: Norihiko
authors.initials: N
authors.lastname: Shimoyama
authors.forename: Tsugumi
authors.initials: T
authors.lastname: Satoh
authors.forename: Yoshiya
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Kazuteru
authors.initials: K
authors.lastname: Hatanaka
authors.forename: Taiki
authors.initials: T
authors.lastname: Kudo
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Ohno
authors.forename: Kazuharu
authors.initials: K
authors.lastname: Suzuki
authors.forename: Hajime
authors.initials: H
authors.lastname: Hirata
authors.forename: Marina
authors.initials: M
authors.lastname: Suzuki
mesh_terms: D000368:Aged; D001344:Autopsy; D006528:Carcinoma, Hepatocellular / Q000150:complications* / Q000000981:diagnostic imaging; D006801:Humans; D007003:Hypoglycemia / Q000209:etiology*; D007335:Insulin-Like Growth Factor II / Q000096:biosynthesis*; D008113:Liver Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D014057:Tomography, X-Ray Computed
chemical_list: D007335:Insulin-Like Growth Factor II