title: Evidence for Use of Teriparatide in Spinal Fusion Surgery in Osteoporotic Patients.
abstract: BACKGROUND
  Osteoporosis is defined as bone mineral density.
  
  
  METHODS
  A PubMed literature review was performed to review preclinical and clinical evidence for the use of teriparatide in osteoporotic patients undergoing spine fusion surgery.
  
  
  RESULTS
  Preclinical studies in animal models show that teriparatide increases spinal fusion rates. Early clinical studies show that teriparatide both increases spinal fusion rates and decreases hardware loosening in the setting of postmenopausal osteoporosis.
  
  
  CONCLUSIONS
  Ongoing additional trials will help formulate preoperative screening recommendations, determine the optimal duration of preoperative and postoperative teriparatide treatment, and investigate its utility in men.
authors.affiliation: Department of Neurosurgery, School of Medicine, Stanford University, Stanford, California, USA; Department of Neurosurgery, Veterans Affairs Hospital, Palo Alto, California, USA. Electronic address: navjotc@stanford.edu.
authors.forename: Navjot
authors.initials: N
authors.lastname: Chaudhary
authors.affiliation: Cooperative Studies Program Coordinating Center, Veterans Affairs Hospital, Palo Alto, California, USA; Division of Endocrinology, School of Medicine, Stanford University, Stanford, California, USA.
authors.forename: Jennifer S
authors.initials: JS
authors.lastname: Lee
authors.affiliation: Division of Endocrinology, School of Medicine, Stanford University, Stanford, California, USA.
authors.forename: Joy Y
authors.initials: JY
authors.lastname: Wu
authors.affiliation: Department of Neurosurgery, School of Medicine, Stanford University, Stanford, California, USA; Department of Neurosurgery, Veterans Affairs Hospital, Palo Alto, California, USA.
authors.forename: Suzanne
authors.initials: S
authors.lastname: Tharin
mesh_terms: D000818:Animals; D050071:Bone Density Conservation Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D019317:Evidence-Based Medicine; D017102:Fracture Healing / Q000187:drug effects*; D006801:Humans; D010024:Osteoporosis / Q000175:diagnosis / Q000188:drug therapy*; D011292:Premedication; D016103:Spinal Fractures / Q000188:drug therapy / Q000601:surgery*; D013123:Spinal Fusion / Q000379:methods*; D019379:Teriparatide / Q000008:administration & dosage* / Q000494:pharmacology; D016896:Treatment Outcome
chemical_list: D050071:Bone Density Conservation Agents; D019379:Teriparatide
keywords: Osteoporosis; Spine fusion; Teriparatide