title: Study of the effects of polymerized porcine hemoglobin (pPolyHb) in an acute anemia rat model.
abstract: The objective of this study was to investigate the recovery ability of polymerized porcine hemoglobin (pPolyHb) in a rat model of acute anemia caused by normovolemic hemodilution (ANH). After the ANH procedure, rats were infused with either pPolyHb or red blood cells. The results showed pPolyHb could carry a sufficient amount of oxygen to the tissues to maintain normal aerobic metabolism and hemodynamic stability, without any significant toxic effects on renal and liver function according to pathological, and biochemical analysis. The data suggest pPolyHb may be a good candidate for the treatment of acute anemia in future clinical trials.
authors.affiliation: a College of Life Science , Northwest University , Xi'an , PR China.|b National Engineering Research Center for Miniaturized Detection Systems , Northwest University , Xi'an , PR China.
authors.forename: Huifang
authors.initials: H
authors.lastname: Liu
authors.affiliation: a College of Life Science , Northwest University , Xi'an , PR China.|b National Engineering Research Center for Miniaturized Detection Systems , Northwest University , Xi'an , PR China.
authors.forename: Chengbin
authors.initials: C
authors.lastname: Yan
authors.affiliation: a College of Life Science , Northwest University , Xi'an , PR China.|b National Engineering Research Center for Miniaturized Detection Systems , Northwest University , Xi'an , PR China.
authors.forename: Kunping
authors.initials: K
authors.lastname: Yan
authors.affiliation: c School of public health, The First Affiliated Hospital of Xi' an Jiaotong University , Xi'an , PR China.
authors.forename: Wenjin
authors.initials: W
authors.lastname: Zhu
authors.affiliation: a College of Life Science , Northwest University , Xi'an , PR China.|b National Engineering Research Center for Miniaturized Detection Systems , Northwest University , Xi'an , PR China.
authors.forename: Yuesheng
authors.initials: Y
authors.lastname: Shen
authors.affiliation: a College of Life Science , Northwest University , Xi'an , PR China.|b National Engineering Research Center for Miniaturized Detection Systems , Northwest University , Xi'an , PR China.
authors.forename: Bo
authors.initials: B
authors.lastname: Yang
authors.affiliation: a College of Life Science , Northwest University , Xi'an , PR China.|b National Engineering Research Center for Miniaturized Detection Systems , Northwest University , Xi'an , PR China.
authors.forename: Chao
authors.initials: C
authors.lastname: Chen
authors.affiliation: a College of Life Science , Northwest University , Xi'an , PR China.|b National Engineering Research Center for Miniaturized Detection Systems , Northwest University , Xi'an , PR China.
authors.forename: Hongli
authors.initials: H
authors.lastname: Zhu
mesh_terms: D000208:Acute Disease; D000693:Anaerobiosis / Q000187:drug effects; D000740:Anemia / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001802:Blood Substitutes / Q000494:pharmacology* / Q000627:therapeutic use; D004195:Disease Models, Animal; D006339:Heart Rate / Q000187:drug effects; D006454:Hemoglobins / Q000494:pharmacology* / Q000627:therapeutic use; D006863:Hydrogen-Ion Concentration; D008297:Male; D010100:Oxygen / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013552:Swine
chemical_list: D001802:Blood Substitutes; D006454:Hemoglobins; C079129:hemoglobin polymer; D010100:Oxygen
keywords: Polymerized porcine hemoglobin; acute anemia; normovolemic hemodilution; oxygen delivery