title: Validating an image-based fNIRS approach with fMRI and a working memory task.
abstract: In the current study, we extend a previous methodological pipeline by adding a novel image reconstruction approach to move functional near-infrared (fNIRS) signals from channel-space on the surface of the head to voxel-space within the brain volume. We validate this methodology by comparing voxel-wise fNIRS results to functional magnetic resonance imaging (fMRI) results from a visual working memory (VWM) task using two approaches. In the first approach, significant voxel-wise correlations were observed between fNIRS and fMRI measures for all experimental conditions across brain regions in the fronto-parieto-temporal cortices. In the second approach, we conducted separate multi-factorial ANOVAs on fNIRS and fMRI measures and then examined the correspondence between main and interaction effects within common regions of interest. Both fMRI and fNIRS showed similar trends in activation within the VWM network when the number of items held in working memory increases. These results validate the image-based fNIRS approach.
authors.affiliation: School of Psychology, University of East Anglia, Norwich NR4 7TJ, United Kingdom. Electronic address: S.Wijeakumar@uea.ac.uk.
authors.forename: Sobanawartiny
authors.initials: S
authors.lastname: Wijeakumar
authors.affiliation: Department of Radiology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
authors.forename: Theodore J
authors.initials: TJ
authors.lastname: Huppert
authors.affiliation: Department of Radiology, University of Iowa, IA 52242, USA.
authors.forename: Vincent A
authors.initials: VA
authors.lastname: Magnotta
authors.affiliation: University of Tennessee, Department of Psychology, Knoxville, TN 37996, USA.
authors.forename: Aaron T
authors.initials: AT
authors.lastname: Buss
authors.affiliation: School of Psychology, University of East Anglia, Norwich NR4 7TJ, United Kingdom. Electronic address: j.spencer@uea.ac.uk.
authors.forename: John P
authors.initials: JP
authors.lastname: Spencer
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging; D001931:Brain Mapping / Q000379:methods; D003198:Computer Simulation; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D009010:Monte Carlo Method; D064847:Multimodal Imaging; D059906:Neuroimaging / Q000379:methods*; D011597:Psychomotor Performance / Q000502:physiology; D015203:Reproducibility of Results; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D014796:Visual Perception / Q000502:physiology; D055815:Young Adult
keywords: Functional magnetic resonance imaging; Functional near-infrared spectroscopy; Image reconstruction; Visual working memory; Working memory load