title: Patient Perspectives on Deep Brain Stimulation Clinical Research in Early Stage Parkinson's Disease.
abstract: The FDA has approved a multicenter, double-blind, Phase III, pivotal trial testing deep brain stimulation (DBS) in 280 people with very early stage Parkinson's disease (PD; IDE#G050016). In partnership with The Michael J. Fox Foundation for Parkinson's Research, we conducted a survey to investigate motivating factors, barriers, and gender differences among potentially eligible patients for participation in a trial testing DBS in early PD compared to standard medical treatment. The majority of survey respondents (72%) indicated they would consider learning more about participating. Early PD patients are therefore likely to consider enrolling in trials of invasive therapies that may slow symptom progression and help future patients.
authors.affiliation: Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.|Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Lauren
authors.initials: L
authors.lastname: Heusinkveld
authors.affiliation: Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
authors.forename: Mallory
authors.initials: M
authors.lastname: Hacker
authors.affiliation: Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
authors.forename: Maxim
authors.initials: M
authors.lastname: Turchan
authors.affiliation: Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
authors.forename: Madelyn
authors.initials: M
authors.lastname: Bollig
authors.affiliation: Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
authors.forename: Christina
authors.initials: C
authors.lastname: Tamargo
authors.affiliation: Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
authors.forename: William
authors.initials: W
authors.lastname: Fisher
authors.affiliation: The Michael J. Fox Foundation for Parkinson's Research, New York, NY, USA.
authors.forename: Lauren
authors.initials: L
authors.lastname: McLaughlin
authors.affiliation: The Michael J. Fox Foundation for Parkinson's Research, New York, NY, USA.
authors.forename: Adria
authors.initials: A
authors.lastname: Martig
authors.affiliation: Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
authors.forename: David
authors.initials: D
authors.lastname: Charles
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D046690:Deep Brain Stimulation / Q000706:statistics & numerical data; D004311:Double-Blind Method; D008137:Longitudinal Studies; D010300:Parkinson Disease / Q000628:therapy; D010342:Patient Acceptance of Health Care
keywords: Parkinson’s disease; deep brain stimulation; patient preference; surveys