title: Full Out-of-Die Compressibility and Compactibility Profiles From Two Tablets.
abstract: In this study, a method is presented that can be used to generate full out-of-die compressibility and compactibility profiles using the data from only 2 tablets. For each material, one tablet was compacted at the maximum pressure of interest and a second tablet at a relatively low pressure. The in-die data collected during compaction to the maximum pressure of interest and the solid fraction change after ejection for both tablets were used to generate a profile equivalent to a complete out-of-die compressibility profile. After measuring the tensile strengths of each tablet, a compactibility profile was produced by fitting the out-of-die porosity and tensile strength data to the Ryshkewitch-Duckworth equation. This method generated accurate out-of-die compressibility and compactibility profiles for each of the materials studied. Not only is this technique computationally simple, but in cases where only small amounts of raw material are available, this method allows a detailed understanding of a material's mechanical behavior to be assessed.
authors.affiliation: Pre-Pivotal Oral and Enabling Delivery Systems, Amgen Inc., 1 Amgen Center Drive, Thousand Oaks, California 91320.
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Katz
authors.affiliation: Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, Pennsylvania 15282. Electronic address: buckneri@duq.edu.
authors.forename: Ira S
authors.initials: IS
authors.lastname: Buckner
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods*; D019245:Compressive Strength; D016062:Porosity; D013314:Stress, Mechanical; D013607:Tablets / Q000032:analysis / Q000737:chemistry*
chemical_list: D013607:Tablets
keywords: compaction; compression; mechanical properties; powder technology; tablet; tableting