title: Representativeness of Honeypot Trial Participants to Australasian PD Patients.
abstract: BACKGROUND
  The HONEYPOT trial failed to establish the superiority of exit-site application of Medihoney compared with nasal mupirocin prophylaxis for the prevention of peritonitis in peritoneal dialysis (PD) patients. This study aimed to assess the representativeness of the patients in the HONEYPOT trial to the Australian and New Zealand PD population.
  
  
  METHODS
  This study compared baseline characteristics of the 371 PD patients in the HONEYPOT trial with those of 6,085 PD patients recorded on the Australia and New Zealand Dialysis and Transplant (ANZDATA) Registry.
  
  
  RESULTS
  Compared with the PD population, the HONEYPOT sample was older (standardized difference [d] = 0.19,p= 0.003), more likely to be treated with automated PD (d= 0.58,p< 0.001), had higher residual renal function (d= 0.26,p< 0.001) and a higher proportion of participants with end-stage kidney disease due to polycystic kidney disease (d= 0.17) and lower proportion due to diabetes (d= -0.17) and glomerulonephritis (d= -0.18) (p< 0.001), and lower proportions of indigenous people (d= -0.17,p< 0.001), current smokers (d= -0.10,p< 0.001), and people with prior histories of hemodialysis (d= -0.16,p< 0.001), diabetes mellitus (d= -0.18,p< 0.001), and coronary artery disease (d= -0.15,p< 0.001).
  
  
  CONCLUSIONS
  HONEYPOT trial participants tended to be healthier than the Australian and New Zealand PD patient population. Although the differences between the groups were generally modest, it is possible that their cumulative effect may have had some impact on external generalizability, which is not an uncommon occurrence in clinical trials.
authors.affiliation: Australasian Kidney Trials Network, University of Queensland, Brisbane, Australia.|Department of Nephrology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Australasian Kidney Trials Network, University of Queensland, Brisbane, Australia.|Department of Nephrology, The St George Hospital, Sydney, Australia.
authors.forename: Sunil V
authors.initials: SV
authors.lastname: Badve
authors.affiliation: Australasian Kidney Trials Network, University of Queensland, Brisbane, Australia.
authors.forename: Elaine M
authors.initials: EM
authors.lastname: Pascoe
authors.affiliation: Centre for Research in Evidence-Based Practice, Bond University, Gold Coast, Australia.
authors.forename: Elaine
authors.initials: E
authors.lastname: Beller
authors.affiliation: Australasian Kidney Trials Network, University of Queensland, Brisbane, Australia.|Menzies School of Health Research, Darwin, Australia.
authors.forename: Alan
authors.initials: A
authors.lastname: Cass
authors.affiliation: Australasian Kidney Trials Network, University of Queensland, Brisbane, Australia.|Department of Nephrology, Nambour Hospital, Nambour, Australia.
authors.forename: Carolyn
authors.initials: C
authors.lastname: Clark
authors.affiliation: Australasian Kidney Trials Network, University of Queensland, Brisbane, Australia.|Department of Renal Medicine, North Shore Hospital, Auckland, New Zealand.
authors.forename: Janak
authors.initials: J
authors.lastname: de Zoysa
authors.affiliation: Australasian Kidney Trials Network, University of Queensland, Brisbane, Australia.|Department of Nephrology, The St George Hospital, Sydney, Australia.
authors.forename: Nicole M
authors.initials: NM
authors.lastname: Isbel
authors.affiliation: Department of Nephrology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.
authors.forename: Xusheng
authors.initials: X
authors.lastname: Liu
authors.affiliation: Australasian Kidney Trials Network, University of Queensland, Brisbane, Australia.|Child & Adolescent Renal Service, Lady Cilento Children's Hospital, Brisbane, Australia.
authors.forename: Steven
authors.initials: S
authors.lastname: McTaggart
authors.affiliation: Australasian Kidney Trials Network, University of Queensland, Brisbane, Australia.
authors.forename: Alicia T
authors.initials: AT
authors.lastname: Morrish
authors.affiliation: Australasian Kidney Trials Network, University of Queensland, Brisbane, Australia.|Infection Management Services, Princess Alexandra Hospital, Brisbane, Australia.
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Playford
authors.affiliation: Australasian Kidney Trials Network, University of Queensland, Brisbane, Australia.
authors.forename: Anish
authors.initials: A
authors.lastname: Scaria
authors.affiliation: Australasian Kidney Trials Network, University of Queensland, Brisbane, Australia.|Department of Nephrology, Royal Prince Alfred Hospital, Sydney, Australia.
authors.forename: Paul
authors.initials: P
authors.lastname: Snelling
authors.affiliation: Australasian Kidney Trials Network, University of Queensland, Brisbane, Australia.
authors.forename: Liza A
authors.initials: LA
authors.lastname: Vergara
authors.affiliation: Australasian Kidney Trials Network, University of Queensland, Brisbane, Australia.|Department of Nephrology, Princess Alexandra Hospital, Brisbane, Australia.
authors.forename: Carmel M
authors.initials: CM
authors.lastname: Hawley
authors.affiliation: Australasian Kidney Trials Network, University of Queensland, Brisbane, Australia david.johnson2@health.qld.gov.au.|Department of Nephrology, Princess Alexandra Hospital, Brisbane, Australia.
authors.forename: David W
authors.initials: DW
authors.lastname: Johnson
mesh_terms: D000368:Aged; D001315:Australia; D003430:Cross-Sectional Studies; D005260:Female; D006722:Honey / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016712:Mupirocin / Q000008:administration & dosage*; D009520:New Zealand; D010344:Patient Advocacy; D018579:Patient Selection; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D010538:Peritonitis / Q000517:prevention & control*; D016032:Randomized Controlled Trials as Topic; D012042:Registries; D012107:Research Design; D035842:Research Subjects / Q000706:statistics & numerical data; D012189:Retrospective Studies
chemical_list: D016712:Mupirocin
keywords: Honey; mupirocin; outcomes; peritoneal dialysis; peritonitis; randomized controlled trial; representativeness