title: Do Mitochondria Have an Immune System?
abstract: The question if mitochondria have some kind of immune system is not trivial. The basis for raising this question is the fact that bacteria, which are progenitors of mitochondria, do have an immune system. The CRISPR system in bacteria based on the principle of RNA interference serves as an organized mechanism for destroying alien nucleic acids, primarily those of viral origin. We have shown that mitochondria are also a target for viral attacks, probably due to a related organization of genomes in these organelles and bacteria. Bioinformatic analysis performed in this study has not given a clear answer if there is a CRISPR-like immune system in mitochondria. However, this does not preclude the possibility of mitochondrial immunity that can be difficult to decipher or that is based on some principles other than those of CRISPR.
authors.affiliation: Lomonosov Moscow State University, Belozersky Institute of Physico-Chemical Biology, Moscow, 119991, Russia. zorov@genebee.msu.su.
authors.forename: V A
authors.initials: VA
authors.lastname: Popkov
authors.forename: L D
authors.initials: LD
authors.lastname: Zorova
authors.forename: I O
authors.initials: IO
authors.lastname: Korvigo
authors.forename: D N
authors.initials: DN
authors.lastname: Silachev
authors.forename: S S
authors.initials: SS
authors.lastname: Jankauskas
authors.forename: V A
authors.initials: VA
authors.lastname: Babenko
authors.forename: I B
authors.initials: IB
authors.lastname: Pevzner
authors.forename: T I
authors.initials: TI
authors.lastname: Danilina
authors.forename: S D
authors.initials: SD
authors.lastname: Zorov
authors.forename: E Y
authors.initials: EY
authors.lastname: Plotnikov
authors.forename: D B
authors.initials: DB
authors.lastname: Zorov
mesh_terms: D000818:Animals; D001419:Bacteria / Q000235:genetics / Q000378:metabolism; D064113:CRISPR-Cas Systems; D006801:Humans; D008928:Mitochondria / Q000235:genetics* / Q000378:metabolism*