title: The Lateral Habenula Circuitry: Reward Processing and Cognitive Control.
abstract: There has been a growing interest in understanding the role of the lateral habenula (LHb) in reward processing, affect regulation, and goal-directed behaviors. The LHb gets major inputs from the habenula-projecting globus pallidus and the mPFC, sending its efferents to the dopaminergic VTA and SNc, serotonergic dorsal raphe nuclei, and the GABAergic rostromedial tegmental nucleus. Recent studies have made advances in our understanding of the LHb circuit organization, yet the precise mechanisms of its involvement in complex behaviors are largely unknown. To begin to address this unresolved question, we present here emerging cross-species perspectives with a goal to provide a more refined understanding of the role of the LHb circuits in reward and cognition. We begin by highlighting recent findings from rodent experiments using optogenetics, electrophysiology, molecular, pharmacology, and tracing techniques that reveal diverse neural phenotypes in the LHb circuits that may underlie previously undescribed behavioral functions. We then discuss results from electrophysiological studies in macaques that suggest that the LHb cooperates with the anterior cingulate cortex to monitor action outcomes and signal behavioral adjustment. Finally, we provide an integrated summary of cross-species findings and discuss how further research on the connectivity, neural signaling, and physiology of the LHb circuits can deepen our understanding of the role of the LHb in normal and maladaptive behaviors associated with mental illnesses and drug abuse.
authors.affiliation: Department of Psychology, University of Washington, Seattle, Washington 98195-1525.
authors.forename: Phillip M
authors.identifier: 0000-0002-3023-2983
authors.initials: PM
authors.lastname: Baker
authors.affiliation: Medical University of South Carolina, Department of Neurosciences, Charleston, South Carolina 29425.
authors.forename: Thomas
authors.initials: T
authors.lastname: Jhou
authors.affiliation: Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, vicentica@mail.nih.gov bli@cshl.edu.
authors.forename: Bo
authors.identifier: 0000-0002-0154-3088
authors.initials: B
authors.lastname: Li
authors.affiliation: Division of Biomedical Science, Faculty of Medicine, University of Tsukuba, Ibaraki 305-8577, Japan, and.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Matsumoto
authors.affiliation: Department of Psychology, University of Washington, Seattle, Washington 98195-1525.
authors.forename: Sheri J Y
authors.initials: SJ
authors.lastname: Mizumori
authors.affiliation: Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724.
authors.forename: Marcus
authors.initials: M
authors.lastname: Stephenson-Jones
authors.affiliation: Division of Neuroscience and Basic Behavioral Science, National Institute of Mental Health, Rockville, Maryland 20892 vicentica@mail.nih.gov bli@cshl.edu.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Vicentic
mesh_terms: D000818:Animals; D002755:Choice Behavior / Q000502:physiology*; D003071:Cognition / Q000502:physiology*; D019317:Evidence-Based Medicine; D019262:Habenula / Q000502:physiology*; D006801:Humans; D008959:Models, Neurological; D009415:Nerve Net / Q000502:physiology*; D012201:Reward
keywords: anterior cingulate cortex; cognition; globus pallidus; lateral habenula; punishment; reward; rostromedial tegmental nucleus