title: Sirtuins in metabolism, DNA repair and cancer.
abstract: The mammalian sirtuin family has attracted tremendous attention over the past few years as stress adaptors and post-translational modifier. They have involved in diverse cellular processes including DNA repair, energy metabolism, and tumorigenesis. Notably, genomic instability and metabolic reprogramming are two of characteristic hallmarks in cancer. In this review, we summarize current knowledge on the functions of sirtuins mainly regarding DNA repair and energy metabolism, and further discuss the implication of sirtuins in cancer specifically by regulating genome integrity and cancer-related metabolism.
authors.affiliation: Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, China.|Cancer Research Institute, School of Basic Medicine, Central South University, Changsha, Hunan, 410078, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Mei
authors.affiliation: Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, China.|Cancer Research Institute, School of Basic Medicine, Central South University, Changsha, Hunan, 410078, China.
authors.forename: Xian
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, China.|Cancer Research Institute, School of Basic Medicine, Central South University, Changsha, Hunan, 410078, China.
authors.forename: Jiarong
authors.initials: J
authors.lastname: Yi
authors.affiliation: Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, China.|Cancer Research Institute, School of Basic Medicine, Central South University, Changsha, Hunan, 410078, China.
authors.forename: Junjie
authors.initials: J
authors.lastname: Huang
authors.affiliation: Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, China.|Cancer Research Institute, School of Basic Medicine, Central South University, Changsha, Hunan, 410078, China.
authors.forename: Jian
authors.initials: J
authors.lastname: He
authors.affiliation: Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, China. taoyong@csu.edu.cn.|Cancer Research Institute, School of Basic Medicine, Central South University, Changsha, Hunan, 410078, China. taoyong@csu.edu.cn.
authors.forename: Yongguang
authors.initials: Y
authors.lastname: Tao
mesh_terms: D000818:Animals; D004260:DNA Repair; D004734:Energy Metabolism; D042822:Genomic Instability; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism*; D037761:Sirtuins / Q000378:metabolism*
chemical_list: D037761:Sirtuins
keywords: Cancer; DNA damage; Metabolism; Post-translation modification; Sirtuin