title: Polyphenols Isolated from Xanthoceras sorbifolia Husks and Their Anti-Tumor and Radical-Scavenging Activities.
abstract: Xanthoceras sorbifoliaBunge. is used in traditional medicine in North China. To evaluate the anti-tumor and radical-scavenging activities ofX. sorbifoliahusks polyphenols and determine their structure-activity relationships, 37 polyphenols1-37were obtained by bioassay-guided fractionation. Two new compounds1-2, and compounds5,6,8,9,11,14-17,21-25,27-29,31,33,34,36, and37were isolated from the genusXanthocerasfor the first time. Compounds1-37did not show strong cytotoxicity against the four tested tumor cell lines (A549, HepG2, MGC-803, and MFC) compared to paclitaxel and under the conditions tested in the anti-tumor assay, but compounds3,4,7,8,10,18-20,25,26,29,30,32, and35exhibited stronger radical-scavenging activity than ascorbic acid in a 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt assay. This was the first report on the anti-tumor and radical-scavenging activities of the polyphenols isolated fromX. sorbifoliahusks. Overall, the present study contributed valuable information concerningX. sorbifoliahusks use in medicine and pharmacology.
authors.affiliation: CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China. yangaccn@163.com.|School of Pharmacy, Institute of Materia Medica, North Sichuan Medical College, Nanchong 637007, China. yangaccn@163.com.
authors.forename: Chun-Yan
authors.initials: CY
authors.lastname: Yang
authors.affiliation: CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China. hawei2012@licp.cas.cn.
authors.forename: Wei
authors.initials: W
authors.lastname: Ha
authors.affiliation: Department of Preventive Medicine, North Sichuan Medical College, Nanchong 637007, China. lin-yong@vip.sina.com.
authors.forename: Yong
authors.initials: Y
authors.lastname: Lin
authors.affiliation: CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China. jiangk15@licp.cas.cn.
authors.forename: Kan
authors.initials: K
authors.lastname: Jiang
authors.affiliation: CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China. yangjl@licp.cas.cn.
authors.forename: Jun-Li
authors.initials: JL
authors.lastname: Yang
authors.affiliation: CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China. shiyp@licp.cas.cn.
authors.forename: Yan-Ping
authors.initials: YP
authors.lastname: Shi
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D056945:Hep G2 Cells; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D059808:Polyphenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D029631:Sapindaceae / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D016166:Free Radical Scavengers; D059808:Polyphenols
keywords: Xanthoceras sorbifolia; anti-tumor activity; extracts; polyphenols; radical-scavenging activity