title: Diagnostic Accuracy of Serum Cystatin C for the Evaluation of Renal Dysfunction in Diabetic Patients: A Meta-Analysis.
abstract: This study aimed to evaluate the diagnostic value of serum cystatin C for renal dysfunction in diabetic patients. Eligible trials were searched from multiple databases, the data were extracted into a 2 × 2 table after the quality assessment of included articles. The pooled sensitivity, specificity and other parameters of accuracy of cystatin C were analyzed using Stata version 12.0. Seventeen studies involving 2173 patients were included. The pooled sensitivity and specificity of serum cystatin C for the diagnosis of renal dysfunction were 0.88 (95% CI: 0.83-0.91) and 0.87 (95% CI: 0.82-0.91), respectively. The positive likelihood ratio was 6.69 (95% CI: 4.83-9.26), negative likelihood ratio was 0.14 (95% CI: 0.10-0.20) and diagnostic odds ratio (DOR) was 46.57 (95% CI: 27.76-78.13). The area under the receiver operating characteristic curve was 0.94. Analysis of the 12 studies that investigated serum creatinine indicated that serum cystatin C was more accurate than serum creatinine for the diagnosis of renal dysfunction. Our results indicate that serum cystatin C is an effective index in diagnosing renal dysfunction comparing serum creatinine, serum cystatin C is more sensitivity for evaluation of renal function in diabetic patients.
authors.affiliation: Departments of Nephrology, The Third Xiangya Hospital Central South University, Changsha, Hunan Province, China.
authors.forename: Shi-Kun
authors.initials: SK
authors.lastname: Yang
authors.affiliation: Departments of Nephrology, The Third Xiangya Hospital Central South University, Changsha, Hunan Province, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.affiliation: Departments of Nephrology, The Third Xiangya Hospital Central South University, Changsha, Hunan Province, China.
authors.forename: Xian-Ming
authors.initials: XM
authors.lastname: Zhang
authors.affiliation: Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
authors.forename: Chun
authors.initials: C
authors.lastname: Hu
authors.affiliation: Departments of Nephrology, The Third Xiangya Hospital Central South University, Changsha, Hunan Province, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Sun
authors.affiliation: Departments of Nephrology, The Third Xiangya Hospital Central South University, Changsha, Hunan Province, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Zhang
mesh_terms: D055316:Cystatin C / Q000097:blood*; D003920:Diabetes Mellitus / Q000097:blood* / Q000503:physiopathology*; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D007674:Kidney Diseases / Q000097:blood* / Q000150:complications / Q000503:physiopathology*; D007677:Kidney Function Tests / Q000706:statistics & numerical data; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D055316:Cystatin C
keywords: Cystatin C; Diabetes mellitus; Diagnosis; Estimated glomerular filtration rate; Meta-analysis; Renal dysfunction