title: Cost-Utility of Video-Electroencephalography Monitoring Followed by Surgery in Adults with Drug-Resistant Focal Epilepsy in Thailand.
abstract: This study assessed whether video-electroencephalography (VEEG) monitoring followed by surgery was cost-effective in adult patients with drug-resistant focal epilepsy under Thai health care context, as compared with continued medical treatment without VEEG.
  
  
  
  The total cost (in Thai Baht, THB) and effectiveness (in quality-adjusted life years, QALYs) were estimated over a lifetime horizon, using a decision tree and a Markov model. Data on short-term surgical outcomes, direct health care costs, and utilities were collected from Thai patients in a specialized hospital. Long-term outcomes and relative effectiveness of the surgery over medical treatment were derived, using systematic reviews of published literature.
  
  
  
  Seizure-free rates at years 1 and 2 after surgery were 79.4% and 77.8%, respectively. Costs of VEEG and surgery plus 1-year follow-up care were 216,782 THB, of which the VEEG and other necessary investigations were the main cost drivers (42.8%). On the basis of societal perspective, the total cost over a 40-year horizon accrued to 1,168,679 THB for the VEEG option, 64,939 THB higher than that for no VEEG. The VEEG option contributed to an additional 1.50 QALYs over no VEEG, resulting in an incremental cost-effectiveness ratio of 43,251 THB (USD 1236) per 1 QALY gained. Changes in key parameters had a minimal impact on the incremental cost-effectiveness ratio. Accounting for uncertainty, there was an 84% probability that the VEEG option was cost-effective on the basis of Thailand's cost-effective threshold of 160,000 THB/QALY.
  
  
  
  For patients with drug-resistant epilepsy, VEEG monitoring followed by epilepsy surgery was cost-effective in Thailand. Therefore it should be recommended for health insurance coverage.
authors.affiliation: Pharmacy and Health System Program, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen.
authors.forename: Pimprapa
authors.initials: P
authors.lastname: Kitwitee
authors.affiliation: Department of Neurology, Prasat Neurological Institute, Bangkok.
authors.forename: Kanjana
authors.initials: K
authors.lastname: Unnwongse
authors.affiliation: Department of Neurosurgery, Prasat Neurological Institute, Bangkok.
authors.forename: Teeradej
authors.initials: T
authors.lastname: Srikijvilaikul
authors.affiliation: Department of Neurology, Prasat Neurological Institute, Bangkok.
authors.forename: Tinonkorn
authors.initials: T
authors.lastname: Yadee
authors.affiliation: Department of linical Pharmacy, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, Thailand.
authors.forename: Chulaporn
authors.initials: C
authors.lastname: Limwattananon
mesh_terms: D000328:Adult; D003362:Cost-Benefit Analysis; D004351:Drug Resistance; D004569:Electroencephalography / Q000191:economics* / Q000379:methods; D004828:Epilepsies, Partial / Q000175:diagnosis* / Q000191:economics / Q000601:surgery; D017034:Epilepsy, Frontal Lobe / Q000175:diagnosis / Q000191:economics / Q000601:surgery; D005260:Female; D006801:Humans; D007902:Length of Stay; D008297:Male; D049268:Positron-Emission Tomography / Q000191:economics; D019057:Quality-Adjusted Life Years; D013785:Thailand; D015899:Tomography, Emission-Computed, Single-Photon / Q000191:economics; D014741:Video Recording / Q000191:economics*
keywords: Cost-effectiveness; Drug-resistant epilepsy; Epilepsy surgery; Thailand; Video-electroencephalography