title: Infusion of exogenous cholecystokinin-8, gastrin releasing peptide-29 and their combination reduce body weight in diet-induced obese male rats.
abstract: We hypothesized that exogenous gastrin releasing peptide-29 (GRP-29), cholecystokinin-8 (CCK-8) and their combination reduce body weight (BW). To test this hypothesis, BW was measured in four groups of diet-induced obese (DIO) male rats infused in the aorta (close to the junctions of the celiac and cranial mesenteric arteries) with saline, CCK-8 (0.5 nmol/kg), GRP-29 (0.5 nmol/kg) and CCK-8+GRP-29 (0.5 nmol/kg each) once daily for a total of 23 days. We found that CCK-8, GRP-29 and CCK-8+GRP-29 reduce BW relative to saline control. In conclusion, CCK-8, GRP-29 and their combination reduce BW in the DIO rat model. If infused near their gastrointestinal sites of action CCK-8, GRP-29 and their combination may have a role in regulating BW.
authors.affiliation: Gastroenterology Laboratory, Department of Biomedical Sciences, College of Veterinary Medicine, Tuskegee University, Tuskegee, AL 36088, USA.
authors.forename: Thaer R
authors.initials: TR
authors.lastname: Mhalhal
authors.affiliation: Gastroenterology Laboratory, Department of Biomedical Sciences, College of Veterinary Medicine, Tuskegee University, Tuskegee, AL 36088, USA.
authors.forename: Martha C
authors.initials: MC
authors.lastname: Washington
authors.affiliation: Gastroenterology Laboratory, Department of Biomedical Sciences, College of Veterinary Medicine, Tuskegee University, Tuskegee, AL 36088, USA.
authors.forename: Kayla
authors.initials: K
authors.lastname: Newman
authors.affiliation: Gastroenterology Laboratory, Department of Biomedical Sciences, College of Veterinary Medicine, Tuskegee University, Tuskegee, AL 36088, USA.
authors.forename: John C
authors.initials: JC
authors.lastname: Heath
authors.affiliation: Gastroenterology Laboratory, Department of Biomedical Sciences, College of Veterinary Medicine, Tuskegee University, Tuskegee, AL 36088, USA. Electronic address: sayeghai@mytu.tuskegee.edu.
authors.forename: Ayman I
authors.initials: AI
authors.lastname: Sayegh
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D002766:Cholecystokinin / Q000008:administration & dosage*; D004032:Diet / Q000009:adverse effects; D004359:Drug Therapy, Combination; D019886:Gastrin-Releasing Peptide / Q000008:administration & dosage*; D005765:Gastrointestinal Agents / Q000008:administration & dosage*; D007263:Infusions, Parenteral; D008297:Male; D009765:Obesity / Q000188:drug therapy* / Q000209:etiology; D010446:Peptide Fragments / Q000008:administration & dosage*; D051381:Rats; D015431:Weight Loss
chemical_list: D005765:Gastrointestinal Agents; D010446:Peptide Fragments; C410885:cholecystokinin 8; D019886:Gastrin-Releasing Peptide; D002766:Cholecystokinin
keywords: Aorta; Body weight; Cholecystokinin-8; Diet-induced obese rats; Gastrin releasing Peptide-29