title: Evaluation of NF-κB concentration in patients with tick-borne encephalitis, neuroborreliosis, anaplasmosis and Anaplasma phagocythophilum with tick-borne encephalitis virus co-infection.
abstract: The aim of the study was the evaluation of NF-κB concentration in serum and cerebrospinal fluid (CSF) of patients with diagnosis of tick-borne diseases: tick-borne encephalitis (TBE), neuroborreliosis (NB), anaplasmosis (ANA) and patients co-infected with tick-borne encephalitis virus and Anaplasma phagocythophilum (TBE+ANA). Additionally NF-κB concentration during acute and convalescent period was compared.
  
  
  
  Sixty-seven patients with diagnosis of tick-borne diseases were included in the study. The control group (CG) consisted of 18 patients hospitalized because of headaches and had lumbar puncture performed. The NF-κB was measured by human inhibitory subunit of NF-κB ELISA Kit during acute and convalescent period.
  
  
  
  In serum the significant differences were observed only in patients with TBE+ANA co-infection. In CSF the concentration of NF-κB was significantly higher in patients with TBE, TBE+ANA co-infection, and patients with NB than in CG. Receiver operating characteristic (ROC) curves analysis showed that NF-κB concentration in CSF differentiated patients with NB with CG; patients co-infected with TBE and ANA with CG and patients with TBE with CG. NF-κB concentration in serum differentiated patients co-infected with TBE and ANA with NB and with ANA, with TBE and with CG. In TBE group the serum NF-κB concentration significantly decreased in convalescent period, while in NB and TBE groups significant CSF decrease of NF-κB concentration was observed.
authors.affiliation: Department of Infectious Diseases and Neuroinfections, Medical University of Bialystok, Poland. Electronic address: annamoniuszko@op.pl.
authors.forename: Anna
authors.initials: A
authors.lastname: Moniuszko-Malinowska
authors.affiliation: Department of Infectious Diseases and Neuroinfections, Medical University of Bialystok, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Czupryna
authors.affiliation: Department of Infectious Diseases and Neuroinfections, Medical University of Bialystok, Poland.
authors.forename: Justyna
authors.initials: J
authors.lastname: Dunaj
authors.affiliation: Department of Infectious Diseases and Neuroinfections, Medical University of Bialystok, Poland.
authors.forename: Renata
authors.initials: R
authors.lastname: Swierzbinska
authors.affiliation: Department of Infectious Diseases and Neuroinfections, Medical University of Bialystok, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Guziejko
authors.affiliation: Department of Respiratory Diagnostics and Bronchoscopy, Medical University of Bialystok, Poland.
authors.forename: Ryszard
authors.initials: R
authors.lastname: Rutkowski
authors.affiliation: Department of Infectious Diseases and Neuroinfections, Medical University of Bialystok, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Zajkowska
authors.affiliation: Department of Infectious Diseases and Neuroinfections, Medical University of Bialystok, Poland.
authors.forename: Sambor
authors.initials: S
authors.lastname: Grygorczuk
authors.affiliation: Department of Infectious Diseases and Neuroinfections, Medical University of Bialystok, Poland.
authors.forename: Maciej
authors.initials: M
authors.lastname: Kondrusik
authors.affiliation: Department of Infectious Diseases and Neuroinfections, Medical University of Bialystok, Poland.
authors.forename: Sławomir
authors.initials: S
authors.lastname: Pancewicz
mesh_terms: D000328:Adult; D000368:Aged; D041081:Anaplasma phagocytophilum; D060085:Coinfection / Q000097:blood*; D016873:Ehrlichiosis / Q000097:blood* / Q000150:complications; D004675:Encephalitis, Tick-Borne / Q000097:blood* / Q000150:complications; D005260:Female; D006801:Humans; D020852:Lyme Neuroborreliosis / Q000097:blood* / Q000150:complications; D008297:Male; D008875:Middle Aged; D016328:NF-kappa B / Q000097:blood*
chemical_list: D016328:NF-kappa B
keywords: Co-infection; NF-κB; Tick-borne diseases