title: Baroreflex Sensitivity Predicts Short-Term Outcome of Postural Tachycardia Syndrome in Children.
abstract: OBJECTIVE
  The study was designed to examine if baroreflex sensitivity (BRS) could predict the short-term outcome of postural tachycardia syndrome (POTS) in children.
  
  
  METHODS
  Seventy-seven children subjects were included in the study. Among them, 45 children were in the POTS group and another 32 healthy children were in the control group. A ninety-day clinical follow-up was conducted and the symptom score before and after the follow-up was calculated for POTS patients by using POTS score system. Hemodynamics and continuous BRS monitoring were recorded by Finapres Medical System-FMS (FinometerPRO, FMS Company, Netherlands). According to the symptom score change during follow-up period, POTS patients were further divided into subgroup A (n = 24) with symptom score decreased by at least two points and subgroup B (n = 21) with symptom score decreased by less than two points. The predictive value of BRS in the short-term outcome of POTS in children was analyzed using receiver-operating characteristic (ROC) curve.
  
  
  RESULTS
  BRS of POTS children was significantly higher than that of the healthy children (18.76±9.96 ms/mmHg vs 10±5.42 ms/mmHg, P<0.01). It was higher in subgroup B than that of subgroup A (24.7±9.9 ms/mmHg vs 13.5±6.6 ms/mmHg, P <0.01). BRS was positively correlated with HR change in POTS Group (r = 0.304, P <0.05). Area under curve (AUC) was 0.855 (95% of confidence interval 0.735-0.975), and BRS of 17.01 ms/mmHg as a cut-off value yielded the predictive sensitivity of 85.7% and specificity of 87.5%.
  
  
  CONCLUSIONS
  BRS is a useful index to predict the short-term outcome of POTS in children.
authors.affiliation: Department of Pediatrics, Peking University First Hospital, Beijing, P. R. China.
authors.forename: Hongxia
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Pediatrics, Peking University First Hospital, Beijing, P. R. China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liao
authors.affiliation: Department of Pediatrics, Peking University First Hospital, Beijing, P. R. China.
authors.forename: Yuli
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Pediatrics, Peking University First Hospital, Beijing, P. R. China.
authors.forename: Ping
authors.initials: P
authors.lastname: Liu
authors.affiliation: Department of Pediatrics, Peking University First Hospital, Beijing, P. R. China.
authors.forename: Chufan
authors.initials: C
authors.lastname: Sun
authors.affiliation: Department of Pediatrics, Peking University First Hospital, Beijing, P. R. China.
authors.forename: Yonghong
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Physiology and Pathophysiology, Peking University Health Sciences Centre, Beijing, P. R. China.
authors.forename: Chaoshu
authors.initials: C
authors.lastname: Tang
authors.affiliation: Department of Pediatrics, Peking University First Hospital, Beijing, P. R. China.
authors.forename: Hongfang
authors.initials: H
authors.lastname: Jin
authors.affiliation: Department of Pediatrics, Peking University First Hospital, Beijing, P. R. China.|Key Laboratory of Cardiovascular Sciences, Ministry of Education, Beijing, P. R. China.
authors.forename: Junbao
authors.initials: J
authors.lastname: Du
mesh_terms: D000293:Adolescent; D017704:Baroreflex / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D008297:Male; D054972:Postural Orthostatic Tachycardia Syndrome / Q000175:diagnosis / Q000503:physiopathology*; D011237:Predictive Value of Tests; D011379:Prognosis; D012372:ROC Curve; D013997:Time Factors