title: Association of triglyceride-to-high density lipoprotein cholesterol ratio to cardiorespiratory fitness in men.
abstract: Both triglyceride-to-high density lipoprotein cholesterol (TG/HDL-C) and cardiorespiratory fitness (CRF) impart risk for all-cause morbidity and mortality independently of conventional risk factors.
  
  
  
  To determine prevalence and/or incidence of high TG/HDL-C ratio in men with low CRF.
  
  
  
  Clinical characteristics and CRF were used to determine prevalence of a TG/HDL-C ratio ≥ 3.5 (high ratio) in 13,954 men of the Cooper Center Longitudinal Study. High-ratio conversion was determined in 10,424 men with normal baseline TG/HDL-C ratio. Hazard ratio (HR) of incident high TG/HDL-C was adjusted for age and waist girth.
  
  
  
  Men with low CRF had the highest prevalence of a high TG/HDL-C ratio. In the population with normal TG/HDL-C, age-adjusted HR of incident high TG/HDL-C ratio was 2.77 times higher in men with lowest CRF than in those with highest CRF. Incidence of conversion of normal to high ratio was 5.5% per year in low CRF population, compared with 1.7% in high CRF subjects. Incidence HR was independent of waist girth. Men who converted from normal to high TG/HDL-C ratio during the follow-up period had increased number of metabolic risk factors and a higher prevalence of metabolic syndrome. Men who did not convert to a high TG/HDL-C ratio retained a low prevalence of metabolic syndrome risk factors.
  
  
  
  A high TG/HDL-C ratio is common in men with low CRF. Metabolic syndrome also is common among those with a high ratio.
authors.affiliation: Departments of Clinical Nutrition and Internal Medicine, Center for Human Nutrition of the University of Texas Southwestern Medical Center, Dallas, TX, USA; The Veterans Administration North Texas Health Care System, Dallas, TX, USA. Electronic address: Gloria.Vega@utsouthwestern.edu.
authors.forename: Gloria Lena
authors.initials: GL
authors.lastname: Vega
authors.affiliation: Departments of Clinical Nutrition and Internal Medicine, Center for Human Nutrition of the University of Texas Southwestern Medical Center, Dallas, TX, USA; The Veterans Administration North Texas Health Care System, Dallas, TX, USA.
authors.forename: Scott M
authors.initials: SM
authors.lastname: Grundy
authors.affiliation: The Cooper Institute, Dallas, TX, USA.
authors.forename: Carolyn E
authors.initials: CE
authors.lastname: Barlow
authors.affiliation: The Cooper Institute, Dallas, TX, USA.
authors.forename: David
authors.initials: D
authors.lastname: Leonard
authors.affiliation: The Cooper Institute, Dallas, TX, USA.
authors.forename: Benjamin L
authors.initials: BL
authors.lastname: Willis
authors.affiliation: The Cooper Institute, Dallas, TX, USA.
authors.forename: Laura F
authors.initials: LF
authors.lastname: DeFina
authors.affiliation: The Cooper Institute, Dallas, TX, USA.
authors.forename: Stephen W
authors.initials: SW
authors.lastname: Farrell
mesh_terms: D000328:Adult; D001823:Body Composition; D000072599:Cardiorespiratory Fitness / Q000502:physiology*; D008076:Cholesterol, HDL / Q000097:blood*; D015444:Exercise; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D024821:Metabolic Syndrome / Q000175:diagnosis / Q000453:epidemiology; D008875:Middle Aged; D015995:Prevalence; D016016:Proportional Hazards Models; D014280:Triglycerides / Q000097:blood*; D055105:Waist Circumference
chemical_list: D008076:Cholesterol, HDL; D014280:Triglycerides
keywords: Cardiorespiratory fitness; TG/HDL-C ratio