title: Selective remote esterification of 8-aminoquinoline amides via copper(ii)-catalyzed C(sp2)-O cross-coupling reaction.
abstract: The remote C-O coupling of quinoline amides at the C5 position has been established using cheap and readily available copper catalyst under mild conditions. The positionally selective esterification protocol afforded C-O coupling products in moderate to excellent yields. Most importantly, this method may provide a potential alternative to the existing ways to build functionalized 5-hydroxyquinoline derivatives, which are utilized as pivotal intermediates in the synthesis of drug candidates.
authors.affiliation: Pharmacy College, Taishan Medical University, Tai'an 271016, China.
authors.forename: Chengcai
authors.initials: C
authors.lastname: Xia
authors.affiliation: Pharmacy College, Taishan Medical University, Tai'an 271016, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Wang
authors.affiliation: College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036, China. chxyzpf@hotmail.com.
authors.forename: Jun
authors.initials: J
authors.lastname: Xu
authors.affiliation: College of Biology and Environmental Engineering, Zhejiang Shuren University, Hangzhou 310015, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Shen
authors.affiliation: Pharmacy College, Taishan Medical University, Tai'an 271016, China.
authors.forename: Di
authors.initials: D
authors.lastname: Sun
authors.affiliation: Pharmacy College, Taishan Medical University, Tai'an 271016, China.
authors.forename: Hongshuang
authors.initials: H
authors.lastname: Li
authors.affiliation: Pharmacy College, Taishan Medical University, Tai'an 271016, China.
authors.forename: Guodong
authors.initials: G
authors.lastname: Wang
authors.affiliation: College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036, China. chxyzpf@hotmail.com.
authors.forename: Pengfei
authors.initials: P
authors.lastname: Zhang