title: Electrochemically Oxidative α-C-H Functionalization of Ketones: A Cascade Synthesis of α-Amino Ketones Mediated by NH4I.
abstract: An efficient electrochemical protocol for the synthesis of α-amino ketones via the oxidative cross-dehydrogenative coupling of ketones and secondary amines has been developed. The electrochemistry performs in a simple undivided cell using NH4I as a redox catalyst and a cheap graphite plate as electrodes under constant current conditions. Gram-scale reaction demonstrates the practicality of the protocol. The reaction is proposed to procced through an initial α-iodination of ketone, followed by a nucleophilic substitution of amines.
authors.affiliation: Beijing Advanced Innovation Center for Food Nutrition and Human Health, School of Food and Chemical Engineering, Beijing Technology and Business University , Beijing100048, China.|Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science & Nutritional Engineering, China Agricultural University , Beijing100083, China.
authors.forename: Sen
authors.initials: S
authors.lastname: Liang
authors.affiliation: Beijing Advanced Innovation Center for Food Nutrition and Human Health, School of Food and Chemical Engineering, Beijing Technology and Business University , Beijing100048, China.|College of Life Science & Bioengineering, Beijing University of Technology , Beijing100124, China.
authors.forename: Cheng-Chu
authors.initials: CC
authors.lastname: Zeng
authors.affiliation: Beijing Advanced Innovation Center for Food Nutrition and Human Health, School of Food and Chemical Engineering, Beijing Technology and Business University , Beijing100048, China.
authors.forename: Hong-Yu
authors.initials: HY
authors.lastname: Tian
authors.affiliation: Beijing Advanced Innovation Center for Food Nutrition and Human Health, School of Food and Chemical Engineering, Beijing Technology and Business University , Beijing100048, China.
authors.forename: Bao-Guo
authors.initials: BG
authors.lastname: Sun
authors.affiliation: Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science & Nutritional Engineering, China Agricultural University , Beijing100083, China.
authors.forename: Xu-Gang
authors.initials: XG
authors.lastname: Luo
authors.affiliation: Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science & Nutritional Engineering, China Agricultural University , Beijing100083, China.
authors.forename: Fa-Zheng
authors.initials: FZ
authors.lastname: Ren