title: Aberrant regional homogeneity in Parkinson's disease: A voxel-wise meta-analysis of resting-state functional magnetic resonance imaging studies.
abstract: Studies of abnormal regional homogeneity (ReHo) in Parkinson's disease (PD) have reported inconsistent results. Therefore, we conducted a meta-analysis using the Seed-based d Mapping software package to identify the most consistent and replicable findings. A systematic literature search was performed to identify eligible whole-brain resting-state functional magnetic resonance imaging studies that had measured differences in ReHo between patients with PD and healthy controls between January 2000 and June 4, 2016. A total of ten studies reporting 11 comparisons (212 patients; 182 controls) were included. Increased ReHo was consistently identified in the bilateral inferior parietal lobules, bilateral medial prefrontal cortices, and left cerebellum of patients with PD when compared to healthy controls, while decreased ReHo was observed in the right putamen, right precentral gyrus, and left lingual gyrus. The results of the current meta-analysis demonstrate a consistent and coexistent pattern of impairment and compensation of intrinsic brain activity that predominantly involves the default mode and motor networks, which may advance our understanding of the pathophysiological mechanisms underlying PD.
authors.affiliation: Department of Neurology, Drum Tower Hospital of Nanjing Medical University, Nanjing, PR China; Department of Neurology, The Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng, PR China.
authors.forename: PingLei
authors.initials: P
authors.lastname: Pan
authors.affiliation: Department of Neurology, Drum Tower Hospital of Nanjing Medical University, Nanjing, PR China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhan
authors.affiliation: Department of Neurology, Drum Tower Hospital of Nanjing Medical University, Nanjing, PR China.
authors.forename: MingXu
authors.initials: M
authors.lastname: Xia
authors.affiliation: Department of Neurology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, PR China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, PR China.
authors.forename: DeNing
authors.initials: D
authors.lastname: Guan
authors.affiliation: Department of Neurology, Drum Tower Hospital of Nanjing Medical University, Nanjing, PR China; Department of Neurology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, PR China; The State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, Jiangsu, PR China; Jiangsu Key Laboratory for Molecular Medicine, Nanjing University Medical School, Nanjing, Jiangsu, PR China; Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, PR China; Nanjing Neuropsychiatry Clinic Medical Center, Nanjing, PR China. Electronic address: xuyun20042001@aliyun.com.
authors.forename: Yun
authors.initials: Y
authors.lastname: Xu
mesh_terms: D001921:Brain; D006801:Humans; D008279:Magnetic Resonance Imaging; D010300:Parkinson Disease
keywords: Default mode network; Meta-analysis; Motor network; Parkinson’s disease; Regional homogeneity; Seed-based d mapping