title: Role of Versican and ADAMTS-1 in Polycystic Ovary Syndrome.
abstract: OBJECTIVE
  ADAMTS-1 is a matrix metalloproteinase which cleaves versican in the cumulus oocyte complex under the effect of luteinizing hormone surge in the periovulatory period. Altered levels may have a role in the pathogenesis of polycystic ovary syndrome (PCOS). We aimed to determine the serum versican and ADAMTS-1 (a disintegrin and metalloproteinase with thrombospondin motif-1) levels in PCOS patients and compare the results with healthy controls.
  
  
  METHODS
  Thirty-eight patients with PCOS and forty healthy controls aged between 15 and 22 years were included in the study. They were sampled according to their basal hormone, serum versican, and ADAMTS-1 levels. Serum versican and ADAMTS-1 levels were measured by enzyme-linked immunosorbent assay. A multivariate logistic regression model was used to identify the independent risk factors of PCOS.
  
  
  RESULTS
  Serum versican levels were significantly decreased in the PCOS group when compared with the controls. The best versican cut-off value for PCOS was calculated to be 33.65 with 76.74% sensitivity and 52.94% specificity. Serum versican levels, homeostasis model assessment of insulin resistance index, a Ferriman-Gallwey score higher than 8, and oligomenorrhea were the strongest predictors of PCOS. Serum versican levels were significantly decreased in PCOS patients. Besides, serum ADAMTS-1 and versican levels were significantly and positively correlated with each other.
  
  
  CONCLUSIONS
  Serum versican levels were significantly decreased in patients with PCOS. This suggests a possible role of versican in ovulatory dysfunction and in the pathogenesis of PCOS.
authors.affiliation: Zekai Tahir Burak Women's Health Training and Research Hospital, Clinic of Perinatology, Ankara, Turkey Phone: +90 312 306 50 00 E-mail: sibel2ozler@gmail.com.
authors.forename: Sibel
authors.initials: S
authors.lastname: Özler
authors.forename: Efser
authors.initials: E
authors.lastname: Öztaş
authors.forename: Aytekin
authors.initials: A
authors.lastname: Tokmak
authors.forename: Merve
authors.initials: M
authors.lastname: Ergin
authors.forename: Meryem
authors.initials: M
authors.lastname: Kuru Pekcan
authors.forename: Başak
authors.initials: B
authors.lastname: Gümüş Güler
authors.forename: Halil İbrahim
authors.initials: Hİ
authors.lastname: Yakut
authors.forename: Nafiye
authors.initials: N
authors.lastname: Yılmaz
mesh_terms: D000071097:ADAMTS1 Protein / Q000097:blood*; D000293:Adolescent; D015992:Body Mass Index; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D016015:Logistic Models; D015999:Multivariate Analysis; D009839:Oligomenorrhea / Q000097:blood / Q000175:diagnosis; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000175:diagnosis; D012372:ROC Curve; D012016:Reference Values; D018570:Risk Assessment / Q000379:methods* / Q000706:statistics & numerical data; D012307:Risk Factors; D053675:Versicans / Q000097:blood*; D055815:Young Adult
chemical_list: C508322:VCAN protein, human; D053675:Versicans; D000071097:ADAMTS1 Protein; C103859:ADAMTS1 protein, human