title: An easy-to-use wound dressing gelatin-bioactive nanoparticle gel and its preliminary in vivo study.
abstract: Beyond promoting hard tissue repairing, bioactive glasses (BGs) have also been proved to be beneficial for wound healing. Nano-scale BGs prepared by sol-gel method were found to have a better performance as they have a larger specific surface area. In this work, bioactive nanoparticles (nBPs) with mean diameter of 12 nm (BP-12) instead of conventional BGs were mixed with gelatin to form an easy-to-use hydrogel as a dressing for skin wound. It was found that the composite of BP-12 and gelatin could form a hydrogel (BP-12/Gel) under 25 °C, which showed pronounced thixotropy at a practically accessible shear rate, therefore become easy to be used for wound cover. In vitro, the composite hydrogel of BP-12 and gelatin had good biocompatibility with the fibroblast cells. In vivo, rapid cutaneous-tissue regeneration and tissue-structure formation within 7 days was observed in the wound-healing experiment performed in rats. This hydrogel is thus a promising easy-to-use wound dressing material.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.|University of Chinese Academy of Sciences, Beijing, 100190, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Wang
authors.affiliation: University of Chinese Academy of Sciences, Beijing, 100190, China.
authors.forename: Feiyan
authors.initials: F
authors.lastname: Zhu
authors.affiliation: Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.|University of Chinese Academy of Sciences, Beijing, 100190, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Cui
authors.affiliation: Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.|University of Chinese Academy of Sciences, Beijing, 100190, China.
authors.forename: Huihui
authors.initials: H
authors.lastname: Ren
authors.affiliation: Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Xie
authors.affiliation: Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
authors.forename: Ailing
authors.initials: A
authors.lastname: Li
authors.affiliation: College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, 225002, China.
authors.forename: Lijun
authors.initials: L
authors.lastname: Ji
authors.affiliation: University of Chinese Academy of Sciences, Beijing, 100190, China. quxz@ucas.ac.cn.
authors.forename: Xiaozhong
authors.initials: X
authors.lastname: Qu
authors.affiliation: Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China. dqiu@iccas.ac.cn.|University of Chinese Academy of Sciences, Beijing, 100190, China. dqiu@iccas.ac.cn.
authors.forename: Dong
authors.initials: D
authors.lastname: Qiu
authors.affiliation: Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China. yangzz@iccas.ac.cn.
authors.forename: Zhenzhong
authors.initials: Z
authors.lastname: Yang
mesh_terms: D016475:3T3 Cells; D000818:Animals; D001458:Bandages; D001672:Biocompatible Materials / Q000737:chemistry; D001706:Biopsy; D002460:Cell Line; D005260:Female; D005347:Fibroblasts / Q000166:cytology*; D005780:Gelatin / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*; D051379:Mice; D008807:Mice, Inbred BALB C; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry*; D051381:Rats; D012038:Regeneration; D012212:Rheology; D012867:Skin / Q000293:injuries*; D013499:Surface Properties; D013696:Temperature; D014783:Viscosity; D014945:Wound Healing
chemical_list: D001672:Biocompatible Materials; D020100:Hydrogels; D005780:Gelatin