title: A new antibacterial silver(I) complex incorporating 2,5-dimethylpyrazine and the anti-inflammatory diclofenac.
abstract: AgI-containing coordination complexes have attracted attention because of their photoluminescence properties and antimicrobial activities and, in principle, these properties depend on the nature of the structural topologies. A novel two-dimensional silver(I) complex with the anti-inflammatory diclofenac molecule, namely bis{μ-2-[2-(2,6-dichloroanilino)phenyl]acetato-κ3O,O':O}bis(μ-2,5-dimethylpyrazine-κ2N:N')silver(I), [Ag2(C14H10Cl2NO2)2(C6H8N2)]n, (I), has been synthesized and characterized by single-crystal X-ray diffraction, revealing that the AgIions are chelated by the carboxylate groups of the anionic 2-[2-(2,6-dichloroanilino)phenyl]acetate (dicl) ligand in a μ3-η1:η2coordination mode. Each dicl ligand links three AgIatoms to generate a one-dimensional infinite chain. Adjacent chains are connected through 2,5-dimethylpyrazine (dmpyz) ligands to form a two-dimensional layer structure parallel to the crystallographic bc plane. The layers are further connected by C-H...π interactions to generate a three-dimensional supramolecular structure. Additionally, the most striking feature is that the structure contains an intramolecular C-H ...Ag anagostic interaction. Furthermore, the title complex has been tested for its in vitro antibacterial activity and is determined to be highly effective on the studied microorganisms.
authors.affiliation: Ondokuz Mayıs University, Faculty of Engineering, Department of Materials Science and Engineering, 55139 Samsun, Turkey.
authors.forename: Sevim
authors.initials: S
authors.lastname: Hamamci Alisir
authors.affiliation: Ondokuz Mayıs University, Arts and Sciences Faculty, Department of Physics, 55139 Samsun, Turkey.
authors.forename: Necmi
authors.initials: N
authors.lastname: Dege
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002614:Chelating Agents / Q000737:chemistry; D018360:Crystallography, X-Ray; D004008:Diclofenac / Q000737:chemistry* / Q000494:pharmacology; D006860:Hydrogen Bonding; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D011719:Pyrazines / Q000737:chemistry* / Q000494:pharmacology; D018030:Silver Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D014961:X-Ray Diffraction
chemical_list: D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002614:Chelating Agents; D011719:Pyrazines; D018030:Silver Compounds; D004008:Diclofenac; C075524:2,5-dimethylpyrazine
keywords: anagostic interaction; anti-inflammatory agent; antibacterial activity; crystal structure; diclofenac; silver(I) complex; two-dimensional coordination polymer