title: Mouse Sensitization and Exposure Are Associated with Asthma Severity in Urban Children.
abstract: BACKGROUND
  Mouse sensitization and exposure are associated with uncontrolled asthma, but whether they are associated with asthma severity, an intrinsic disease characteristic and long-term outcome predictor, is unclear.
  
  
  OBJECTIVE
  To examine relationships between mouse sensitization and/or exposure and asthma severity in urban children.
  
  
  METHODS
  A total of 645 children (5-17 years) with uncontrolled asthma underwent mouse sensitization evaluation. Sensitized children had mouse allergen measured in bedroom dust. Relationships between mouse sensitization, allergen levels, and asthma severity measures (treatment step and Composite Asthma Severity Index [CASI]) were examined using regression models adjusted for age, sex, atopy, study site, race, ethnicity, and insurance.
  
  
  RESULTS
  The study population was predominantly minority (69.6% black, 20.8% Hispanic), low income (61.8%), and mouse sensitized (54.4%). Mean ± SD treatment step was 3.2 ± 1.6, equivalent to medium-dose inhaled corticosteroid. Mean ± SD CASI was 6.5 ± 3.4, reflecting moderate persistent asthma. Mouse sensitization was associated with higher treatment step (3.5 vs 2.9, mouse-sensitized vs nonsensitized, P < .001), independent of potential confounders (β [95% CI], 0.36 [0.07-0.64]; P = .01). Mouse sensitization was associated independently with CASI (β [95% CI], 0.82 [0.16-1.47]; P = .02). Among mouse-sensitized participants, higher bedroom floor and bed Mus m 1 were independently associated with treatment step (β [95% CI], 0.26 [0.09-0.43]; P = .002 and β [95% CI], 0.22 [0.01-0.43]; P = .04), respectively. Higher bedroom floor Mus m 1 was independently associated with CASI (β [95% CI], 0.43 [0.05-0.81]; P = .03).
  
  
  CONCLUSIONS
  Mouse sensitization and exposure are associated with asthma severity, among low-income, minority children. Further studies are needed to determine whether reducing allergen exposure among mouse-sensitized patients with asthma can reduce severity, ultimately altering childhood asthma natural history.
authors.affiliation: Division of Pediatric Allergy/Immunology, Johns Hopkins School of Medicine, Baltimore, Md.
authors.forename: Torie
authors.initials: T
authors.lastname: Grant
authors.affiliation: Division of Pediatric Allergy/Immunology, Johns Hopkins School of Medicine, Baltimore, Md.
authors.forename: Charles
authors.initials: C
authors.lastname: Aloe
authors.affiliation: Department of Environmental Health Sciences, Columbia University, New York, NY.
authors.forename: Matthew
authors.initials: M
authors.lastname: Perzanowski
authors.affiliation: Division of Pediatric Allergy/Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Mass.
authors.forename: Wanda
authors.initials: W
authors.lastname: Phipatanakul
authors.affiliation: Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Md.
authors.forename: Mary E
authors.initials: ME
authors.lastname: Bollinger
authors.affiliation: Department of Environmental Health Sciences, Columbia University, New York, NY; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Columbia University, New York, NY.
authors.forename: Rachel
authors.initials: R
authors.lastname: Miller
authors.affiliation: Division of Pediatric Allergy/Immunology, Johns Hopkins School of Medicine, Baltimore, Md. Electronic address: ematsui@jhmi.edu.
authors.forename: Elizabeth C
authors.initials: EC
authors.lastname: Matsui
mesh_terms: D000293:Adolescent; D000485:Allergens / Q000276:immunology*; D000818:Animals; D001249:Asthma / Q000188:drug therapy / Q000208:ethnology / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D003058:Cockroaches / Q000276:immunology; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D008297:Male; D051379:Mice / Q000276:immunology*; D008913:Minority Groups; D011203:Poverty; D016032:Randomized Controlled Trials as Topic; D012720:Severity of Illness Index; D012882:Skin Tests; D014504:Urban Health; D014505:Urban Population
chemical_list: D000485:Allergens; D007073:Immunoglobulin E
keywords: Childhood asthma; Indoor allergens; Inner-city asthma; Mouse allergen; Mouse sensitization