title: Silver-catalyzed C2-selective direct alkylation of heteroarenes with tertiary cycloalkanols.
abstract: A silver-catalyzed regioselective C2-alkylation of heteroarenes with tertiary cycloalkanols under radical conditions was developed. This tandem process, which includes selective C-H activation, C(sp3)-C(sp3) bond cleavage, and C(sp3)-C(sp2) bond formation, affords a novel and environmentally friendly approach for the production of carbonyl-containing alkyl-substituted heteroarenes with moderate to good yields.
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, and Beijing Key Laboratory of Active Substance Discovery and Drugability Evaluation, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, No. 1 Xiannongtan Street, Beijing 100050, P R China. lushichao@imm.ac.cn.
authors.forename: Shi-Chao
authors.initials: SC
authors.lastname: Lu
authors.affiliation: School of Pharmaceutical Sciences, Taishan Medical University, 619 Changcheng Road, Taian 271016, P R China. lihongshuang8625@163.com.
authors.forename: Hong-Shuang
authors.initials: HS
authors.lastname: Li
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, and Beijing Key Laboratory of Active Substance Discovery and Drugability Evaluation, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, No. 1 Xiannongtan Street, Beijing 100050, P R China. lushichao@imm.ac.cn.
authors.forename: Shu
authors.initials: S
authors.lastname: Xu
authors.affiliation: School of Pharmaceutical Sciences, Taishan Medical University, 619 Changcheng Road, Taian 271016, P R China. lihongshuang8625@163.com.
authors.forename: Gui-Yun
authors.initials: GY
authors.lastname: Duan