title: Modified Profile of Matrix Metalloproteinase 2 and 9 Production by Human Fallopian Tube Epithelial Cells After Infection In Vitro With Neisseria gonorrhoeae.
abstract: Epithelial shedding and scarring of fallopian tube mucosa are the main consequences of sexually transmitted Neisseria gonorrhoeae infection and probably involve an imbalance of host extracellular matrix components and their regulators such as matrix metalloproteinases (MMPs). In the current study, primary human fallopian tube epithelial cells were infected with N. gonorrhoeae, and MMP patterns were examined. Gonococcal infection induced a significant increase in secreted MMP-9 and an accumulation of cytoplasmic MMP-2 over time, but no significant MMP-3 or MMP-8 production was observed. Thus, MMP-9 in particular could play a role in tubal scarring in response to gonococcal infection.
authors.affiliation: Center for Integrative Medicine and Innovative Science.
authors.forename: Paula I
authors.initials: PI
authors.lastname: Rodas
authors.affiliation: Center for Integrative Medicine and Innovative Science.|School of Medical Technology, Faculty of Medicine.
authors.forename: Doris
authors.initials: D
authors.lastname: Pérez
authors.affiliation: Center for Integrative Medicine and Innovative Science.|School of Medical Technology, Faculty of Medicine.
authors.forename: Claudia
authors.initials: C
authors.lastname: Jauffret
authors.affiliation: Center for Integrative Medicine and Innovative Science.
authors.forename: Yaquelin
authors.initials: Y
authors.lastname: González
authors.affiliation: Center for Integrative Medicine and Innovative Science.|School of Medicine, Faculty of Medicine, Universidad Andres Bello.
authors.forename: Carolina
authors.initials: C
authors.lastname: Carreño
authors.affiliation: Laboratorio Clínica Dávila.|Laboratorio de Micología Médica, Programa de Microbiología y Micología, ICBM, Facultad de Medicina, Universidad de Chile.
authors.forename: Cecilia V
authors.initials: CV
authors.lastname: Tapia
authors.affiliation: Servicio de Ginecología y Obstetricia, Clínica Dávila, Santiago, Chile.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Osorio
authors.affiliation: Center for Integrative Medicine and Innovative Science.
authors.forename: Luis A
authors.initials: LA
authors.lastname: Velasquez
authors.affiliation: Neisseria Research Group, Molecular Microbiology, Sir Henry Wellcome Laboratories, Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, United Kingdom.
authors.forename: Myron
authors.initials: M
authors.lastname: Christodoulides
mesh_terms: D004847:Epithelial Cells / Q000378:metabolism*; D005187:Fallopian Tubes / Q000166:cytology*; D005260:Female; D006069:Gonorrhea / Q000378:metabolism*; D006801:Humans; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism*; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism*; D009092:Mucous Membrane / Q000378:metabolism; D009344:Neisseria gonorrhoeae / Q000302:isolation & purification*; D009924:Organ Culture Techniques; D006113:United Kingdom
chemical_list: C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2; C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9
keywords: Neisseria gonorrhoeae; extracellular matrix; human Fallopian tube epithelial cells; matrix metalloproteinases