title: Improving cell penetration of helical peptides stabilized by N-terminal crosslinked aspartic acids.
abstract: Cell penetration and nucleus translocation efficiency are important for the cellular activities of peptide therapeutics. For helical peptides stabilized by N-terminal crosslinked aspartic acid, correlations between their penetration efficiency/nucleus translocation and physicochemical properties were studied. An increase in hydrophobicity and isoelectric point will promote cellular uptake and nucleus translocation of stabilized helices.
authors.affiliation: School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, China. lizg@pkusz.edu.cn.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhao
authors.affiliation: School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, China. lizg@pkusz.edu.cn.
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 611756, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Tian
authors.affiliation: School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, China. lizg@pkusz.edu.cn.
authors.forename: Dan
authors.initials: D
authors.lastname: Yang
authors.affiliation: School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, China. lizg@pkusz.edu.cn.
authors.forename: Xuan
authors.initials: X
authors.lastname: Qin
authors.affiliation: School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, China. lizg@pkusz.edu.cn.
authors.forename: Zigang
authors.initials: Z
authors.lastname: Li
mesh_terms: D001224:Aspartic Acid / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D057846:Cell-Penetrating Peptides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D003432:Cross-Linking Reagents / Q000737:chemistry*; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D061986:MCF-7 Cells; D055550:Protein Stability
chemical_list: D057846:Cell-Penetrating Peptides; D003432:Cross-Linking Reagents; D001224:Aspartic Acid