title: Affective disorders and Health-Related Quality of Life (HRQoL) in adolescents and young adults with Multiple Sclerosis (MS): the moderating role of resilience.
abstract: To investigate the moderating role of resilience in the relationship between affective disorders and Health-Related Quality of Life (HRQoL) for adolescents and young adults with multiple sclerosis (MS).
  
  
  
  A quantitative methodology was adopted. Fifty-three adolescents and young adults were interviewed to assess resilience as a personality trait (Ego-Resiliency Scale) and resilience as an interactive competence (CYRM-28), Health-Related Quality of Life (PedsQL 4.0), depression and anxiety (BDI-II and STAI-Y).
  
  
  
  Affective disorders, both depression (β = -.38, p < .001) and anxiety (State β = -.35, p < .001; Trait β = -.41, p < .001), were negatively associated with HRQoL. Data also showed that the resilience competencies using Individual (β = .22, p < .001) and relational resources (β = .12, p < .05) are significantly associated HRQoL. According to the regression analyses, we tested the moderating role of resilience competence using individual resources on the relationship between the Depression Cognitive Factor and Emotional Functioning. Data show that in step 2 of the regression analysis, we obtained a variation of β = -.45 (p < .001) to β = -.30 (p < .001) in the dimension for the Depression Cognitive Factor. The Sobel test showed that the moderating effect of resilience was significant regarding the increase in R2(p < .01).
  
  
  
  Resilience competence using individual resources moderates the relationship between the Depression Cognitive Factor and Emotional Functioning in adolescents with MS. Our study suggests that to improve well-being for adolescents with MS resilience could play a key role.
authors.affiliation: Department of Humanities, University of Naples "Federico II", via Porta di Massa 1, 80133, Naples, Italy. nunzia.rainone@unina.it.
authors.forename: Nunzia
authors.identifier: 0000-0002-9253-8064
authors.initials: N
authors.lastname: Rainone
authors.affiliation: Department of Neurosciences, Reproductive Science and Odontostomatology, Federico II University, Via Pansini, 5, 80131, Naples, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Chiodi
authors.affiliation: Department of Neurosciences, Reproductive Science and Odontostomatology, Federico II University, Via Pansini, 5, 80131, Naples, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Lanzillo
authors.affiliation: Department of Neurosciences, Reproductive Science and Odontostomatology, Federico II University, Via Pansini, 5, 80131, Naples, Italy.
authors.forename: Valeria
authors.initials: V
authors.lastname: Magri
authors.affiliation: Department of Neurosciences, Reproductive Science and Odontostomatology, Federico II University, Via Pansini, 5, 80131, Naples, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Napolitano
authors.affiliation: Department of Neurosciences, Reproductive Science and Odontostomatology, Federico II University, Via Pansini, 5, 80131, Naples, Italy.
authors.forename: Vincenzo Brescia
authors.initials: VB
authors.lastname: Morra
authors.affiliation: Department of Neurosciences, Reproductive Science and Odontostomatology, Federico II University, Via Pansini, 5, 80131, Naples, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Valerio
authors.affiliation: Department of Humanities, University of Naples "Federico II", via Porta di Massa 1, 80133, Naples, Italy.
authors.forename: Maria Francesca
authors.initials: MF
authors.lastname: Freda
mesh_terms: D000293:Adolescent; D000294:Adolescent Behavior; D016497:Adolescent Health Services; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D019964:Mood Disorders / Q000150:complications / Q000523:psychology*; D009103:Multiple Sclerosis / Q000150:complications / Q000523:psychology*; D011788:Quality of Life / Q000523:psychology; D055500:Resilience, Psychological; D055815:Young Adult
keywords: Adolescence and young adulthood; Affective disorders; Health-Related Quality of Life; Multiple sclerosis; Resilience