title: In-situ particles reorientation during magnetic hyperthermia application: Shape matters twice.
abstract: Promising advances in nanomedicine such as magnetic hyperthermia rely on a precise control of the nanoparticle performance in the cellular environment. This constitutes a huge research challenge due to difficulties for achieving a remote control within the human body. Here we report on the significant double role of the shape of ellipsoidal magnetic nanoparticles (nanorods) subjected to an external AC magnetic field: first, the heat release is increased due to the additional shape anisotropy; second, the rods dynamically reorientate in the orthogonal direction to the AC field direction. Importantly, the heating performance and the directional orientation occur in synergy and can be easily controlled by changing the AC field treatment duration, thus opening the pathway to combined hyperthermic/mechanical nanoactuators for biomedicine. Preliminary studies demonstrate the high accumulation of nanorods into HeLa cells whereas viability analysis supports their low toxicity and the absence of apoptotic or necrotic cell death after 24 or 48 h of incubation.
authors.affiliation: Department of Physics, Aristotle University of Thessaloniki, GR-54124 Thessaloniki Greece.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Simeonidis
authors.affiliation: Instituto de Ciencia de Materiales de Madrid, CSIC, Cantoblanco, ES-28049 Madrid, Spain.
authors.forename: M Puerto
authors.initials: MP
authors.lastname: Morales
authors.affiliation: Instituto de Ciencia de Materiales de Madrid, CSIC, Cantoblanco, ES-28049 Madrid, Spain.
authors.forename: Marzia
authors.initials: M
authors.lastname: Marciello
authors.affiliation: Department of Physics, Aristotle University of Thessaloniki, GR-54124 Thessaloniki Greece.
authors.forename: Makis
authors.initials: M
authors.lastname: Angelakeris
authors.affiliation: Instituto de Magnetismo Aplicado (ADIF-UCM-CSIC), Las Rozas, Madrid 28230, Spain.|Departamento de Física de Materiales, Universidad Complutense de Madrid, Ciudad Universitaria, 28040 Madrid, Spain.
authors.forename: Patricia
authors.initials: P
authors.lastname: de la Presa
authors.affiliation: Departamento de Biología, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Lazaro-Carrillo
authors.affiliation: Departamento de Biología, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain.
authors.forename: Andrea
authors.initials: A
authors.lastname: Tabero
authors.affiliation: Departamento de Biología, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain.|IMDEA Nanociencia, Faraday 9, Cantoblanco, Madrid, Spain.
authors.forename: Angeles
authors.initials: A
authors.lastname: Villanueva
authors.affiliation: Instituto de Ciencia de Materiales de Madrid, CSIC, Cantoblanco, ES-28049 Madrid, Spain.
authors.forename: Oksana
authors.initials: O
authors.lastname: Chubykalo-Fesenko
authors.affiliation: Applied Physics Department and Instituto de Investigacións Tecnolóxicas, Universidade de Santiago de Compostela, 15782, Spain.|Department of Physics, University of York, Heslington, York YO10 5DD, United Kingdom.
authors.forename: David
authors.initials: D
authors.lastname: Serantes
mesh_terms: D016880:Anisotropy; D002470:Cell Survival; D006367:HeLa Cells; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D060526:Magnetic Fields; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D043942:Nanotubes / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size
chemical_list: D058185:Magnetite Nanoparticles