title: Three minor valepotriate isomers from Valeriana jatamansi and their cytotoxicity.
abstract: Three new minor valepotriate isomers, jatamanvaltrates Z1 (1), Z2 (2), and Z3 (3), have been isolated from the whole plants of Valeriana jatamansi (syn. Valeriana wallichii.). Their structures were elucidated by extensive spectroscopic analysis, especially 2D NMR and ESI-MS/MSn. All isolated compounds displayed moderate cytotoxicity against the lung adenocarcinoma (A549), metastatic prostate cancer (PC-3 M), colon cancer (HCT-8), and hepatoma (Bel7402) cell lines with IC50values of 2.8-8.3 μM.
authors.affiliation: a Department of Natural Product Chemistry , School of Pharmacy, Second Military Medical University , Shanghai 200433 , China.|b State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Lin
authors.affiliation: c Department of Pharmacy , Changhai Hospital, Second Military Medical University , Shanghai 200433 , China.
authors.forename: Peng
authors.initials: P
authors.lastname: Fu
authors.affiliation: d State Key Laboratory of Respiratory Disease , Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University , Guangzhou 510120 , China.
authors.forename: Tao
authors.initials: T
authors.lastname: Chen
authors.affiliation: a Department of Natural Product Chemistry , School of Pharmacy, Second Military Medical University , Shanghai 200433 , China.
authors.forename: Ji
authors.initials: J
authors.lastname: Ye
authors.affiliation: a Department of Natural Product Chemistry , School of Pharmacy, Second Military Medical University , Shanghai 200433 , China.
authors.forename: Xian-Wen
authors.initials: XW
authors.lastname: Yang
authors.affiliation: a Department of Natural Product Chemistry , School of Pharmacy, Second Military Medical University , Shanghai 200433 , China.
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Zhang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D003110:Colonic Neoplasms / Q000188:drug therapy; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D039823:Iridoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007536:Isomerism; D008297:Male; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D011471:Prostatic Neoplasms / Q000188:drug therapy; D014632:Valerian / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D039823:Iridoids; C000613942:jatamanvaltrate Z1; C030127:valtrate
keywords: Valeriana jatamansi; Valerianaceae; cytotoxicity; isomers; valepotriates