title: Fibroblast Growth Factor 23 in Postrenal Transplant: An Often Forgotten Hormone.
abstract: Fibroblast growth factor 23 is likely to be the most important regulator of phosphate homeostasis, which mediates its functions through fibroblast growth factor receptors and the coreceptor Klotho. In addition to reducing expression of the sodium-phosphate cotransporters NPT2a and NPT2c in the proximal tubules, fibroblast growth factor 23 inhibits renal 1α-hydroxylase and stimulates 24-hydroxylase and appears to reduce parathyroid hormone secretion in short-term studies. Fibroblast growth factor 23 synthesis and secretion by osteocytes and osteoblasts are upregulated through 1,25-dihydroxyvitamin D3 and through an increased dietary phosphate intake. Recent studies have indicated that a low-protein diet and calcium deficiency reduce circulating fibroblast growth factor 23 levels, but magnesium deficiency increases fibroblast growth factor levels. Drugs such as phosphate binders, bisphosphonate, and estrogens have various effects on circulating fibroblast growth factor 23 levels. The high cardiovascular disease event rates and mortality associated with elevated levels of this hormone may be due to various effects on the cardiovascular system, including left ventricular hypertrophy, arterial stiffness, vascular calcifications, endothelial dysfunction, and increased levels of inflammatory markers. In addition, elevated levels of this hormone may contribute to mineral bone metabolism disorders and to patient and allograft survival after renal transplant. Here, we discuss the effects of fibroblast growth factor 23 on adverse renal, bone, and cardiovascular outcomes after kidney transplant.
authors.affiliation: Division of Nephrology, Department of Kidney Transplantation, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Fateme Shamekhi
authors.initials: FS
authors.lastname: Amiri
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Khatami
mesh_terms: D064591:Allografts; D002117:Calcitriol / Q000172:deficiency; D002318:Cardiovascular Diseases / Q000401:mortality; D012080:Chronic Kidney Disease-Mineral and Bone Disorder; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D006934:Hypercalcemia; D017674:Hypophosphatemia; D016030:Kidney Transplantation / Q000009:adverse effects*; D011183:Postoperative Complications
chemical_list: D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D002117:Calcitriol