title: ARHGEF10 gene polymorphism is closely associated with the risk of ischemic stroke in Northern Han Chinese population.
abstract: Stroke is a common disease with high mortality and morbidity. It is of high importance to identify biomarkers of stroke. Rho guanine nucleotide-exchange factor(GEF) 10 (ARHGEF10) gene polymorphism has been found to be associated with various human diseases, but its correlation with stroke remains unknown. This study aims to evaluate the potential association of the single nucleotide polymorphisms (SNPs) of ARHGEF10 with ischemic stroke (IS) in northern Han Chinese population. Three SNPs of ARHGEF10 gene were analyzed in 385 IS patients and 362 hypertension control patients using the ligase detection reaction (LDR) method. Logistic regression analysis demonstrated that GG genotypes of SNP rs2280887 were associated with an increased risk of IS in dominant, recessive, and additive models. Moreover, SNP rs9657362 and SNP rs4480162 were significantly associated with IS in dominant and additive models. These results indicate that ARHGEF10 gene polymorphisms may affect IS risk in northern Han Chinese.
authors.affiliation: a Department of Cardiology , Shengjing Hospital of China Medical University , Shenyang , China.
authors.forename: Hong
authors.initials: H
authors.lastname: Li
authors.affiliation: b Department of Cardiology , The First Hospital of China Medical University , Shenyang , China.
authors.forename: Shasha
authors.initials: S
authors.lastname: Yu
authors.affiliation: b Department of Cardiology , The First Hospital of China Medical University , Shenyang , China.
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
authors.affiliation: a Department of Cardiology , Shengjing Hospital of China Medical University , Shenyang , China.
authors.forename: Zhaoqing
authors.initials: Z
authors.lastname: Sun
authors.affiliation: b Department of Cardiology , The First Hospital of China Medical University , Shenyang , China.
authors.forename: Xinghu
authors.initials: X
authors.lastname: Zhou
authors.affiliation: c Department of Clinical Epidemiology , Shengjing Hospital of China Medical University , Shenyang , China.
authors.forename: Liqiang
authors.initials: L
authors.lastname: Zheng
authors.affiliation: d Department of Epidemiology , School of Public Health, China Medical University , Shenyang , China.
authors.forename: Zhihua
authors.initials: Z
authors.lastname: Yin
authors.affiliation: b Department of Cardiology , The First Hospital of China Medical University , Shenyang , China.
authors.forename: Xingang
authors.initials: X
authors.lastname: Zhang
authors.affiliation: b Department of Cardiology , The First Hospital of China Medical University , Shenyang , China.
authors.forename: Yingxian
authors.initials: Y
authors.lastname: Sun
mesh_terms: D000368:Aged; D002545:Brain Ischemia / Q000150:complications; D002681:China / Q000453:epidemiology / Q000208:ethnology; D018450:Disease Progression; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000235:genetics; D015810:Linkage Disequilibrium; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D064067:Rho Guanine Nucleotide Exchange Factors / Q000235:genetics*; D020521:Stroke / Q000453:epidemiology / Q000208:ethnology* / Q000209:etiology / Q000235:genetics*
chemical_list: C577232:ARHGEF10 protein, human; D064067:Rho Guanine Nucleotide Exchange Factors
keywords: ARHGEF10; Northern Han Chinese; SNPs; Stroke; gene polymorphism