title: Circulating omentin-1 levels in women with polycystic ovary syndrome: a meta-analysis.
abstract: To investigate the association between circulating omentin-1 levels and polycystic ovary syndrome (PCOS) in women, a meta-analysis was performed. A systematic literature search using PubMed, Embase and Web of Science was carried out. Ten articles with 13 studies were included in this meta-analysis, which included a total of 1264 subjects (733 patients with PCOS and 531 controls). The pooled standard mean difference (SMD) and 95% confidence interval (CI) were used to estimate the association between omentin-1 levels and PCOS. Circulating omentin-1 levels were lower in PCOS with an SMD (95% CI) of -0.67 (-0.91, -0.43) and p = 0.000 (random-effects). However, significant heterogeneity was detected across studies (I2=73.6% and p = 0.000). The subgroup analysis suggested that omentin-1 levels in PCOS patients were associated with HOMA-IR ratio. Meta-regression analysis indicated region was the main source of heterogeneity (p = 0.048). The results of this meta-analysis suggested that circulating omentin-1 levels are significantly lower in women with PCOS compared with controls, which indicated that omentin-1 may play a role in the pathologic processes of PCOS.
authors.affiliation: a Department of Endocrinology and Metabolism and.
authors.forename: Yun-Liang
authors.initials: YL
authors.lastname: Tang
authors.affiliation: a Department of Endocrinology and Metabolism and.
authors.forename: Jiao
authors.initials: J
authors.lastname: Yu
authors.affiliation: b Department of Intensive Care Unit , First Affiliated Hospital of Nanchang University , Nanchang , Jiangxi , PR China.
authors.forename: Zhen-Guo
authors.initials: ZG
authors.lastname: Zeng
authors.affiliation: a Department of Endocrinology and Metabolism and.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.affiliation: a Department of Endocrinology and Metabolism and.
authors.forename: Jian-Ying
authors.initials: JY
authors.lastname: Liu
authors.affiliation: a Department of Endocrinology and Metabolism and.
authors.forename: Ji-Xiong
authors.initials: JX
authors.lastname: Xu
mesh_terms: D000328:Adult; D016207:Cytokines / Q000097:blood*; D015536:Down-Regulation; D005260:Female; D058851:GPI-Linked Proteins / Q000097:blood; D006801:Humans; D007333:Insulin Resistance; D037102:Lectins / Q000097:blood*; D009765:Obesity / Q000097:blood / Q000150:complications; D050177:Overweight / Q000097:blood / Q000150:complications; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications; D015203:Reproducibility of Results
chemical_list: D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D037102:Lectins
keywords: Adipokine; meta-analysis; omentin-1; polycystic ovary syndrome