title: A multifunctionalized strategy of indoles to C2-quaternary indolin-3-ones via a TEMPO/Pd-catalyzed cascade process.
abstract: A method for combinative oxidative homo dimerization and cyanomethylation of free indole derivatives catalysed by TEMPO and Pd(OAc)2was demonstrated for the first time. This new methodology is both atom and step efficient and is applicable to a broad scope of substrates, allowing the synthesis of a range of synthetically valuable 2-(2-(1H-indol-3-yl)-3-oxoindolin-2-yl)acetonitriles in moderate to excellent yields.
authors.affiliation: Department of Chemistry and Chemical Engineering, Gannan Normal University, Ganzhou 341000, PR China. yedongnai@126.com lxliu@xmu.edu.cn.
authors.forename: Zhongfu
authors.initials: Z
authors.lastname: Deng
authors.affiliation: School of Pharmaceutical Science, Gannan Medical University, Ganzhou, Jiangxi 341000, P. R. China.
authors.forename: Xiangjun
authors.initials: X
authors.lastname: Peng
authors.affiliation: Department of Chemistry and Chemical Engineering, Gannan Normal University, Ganzhou 341000, PR China. yedongnai@126.com lxliu@xmu.edu.cn.
authors.forename: Panpan
authors.initials: P
authors.lastname: Huang
authors.affiliation: Department of Chemistry and Chemical Engineering, Gannan Normal University, Ganzhou 341000, PR China. yedongnai@126.com lxliu@xmu.edu.cn.
authors.forename: Lili
authors.initials: L
authors.lastname: Jiang
authors.affiliation: Department of Chemistry and Chemical Engineering, Gannan Normal University, Ganzhou 341000, PR China. yedongnai@126.com lxliu@xmu.edu.cn.
authors.forename: Dongnai
authors.initials: D
authors.lastname: Ye
authors.affiliation: Department of Chemistry and Chemical Engineering, Gannan Normal University, Ganzhou 341000, PR China. yedongnai@126.com lxliu@xmu.edu.cn.
authors.forename: Liangxian
authors.initials: L
authors.lastname: Liu