title: Effect of Variable Doses of Zinc Oxide Nanoparticles on Male Albino Mice Behavior.
abstract: Zinc oxide nanoparticles (ZnO NPs) have diverse utility these days ranging from being part of nanosensors to be ingredient of cosmetics. Present study was designed to report the effect of variable doses of ZnO NPs on selected aspects of male albino mice behavior. Nano particles were synthesized by sol-gel auto-combustion method (Data not shown here). 10 week old male albino mice were divided into four experimental groups; group A, B and C were orally supplemented with 50 (low dose), 300 (medium dose) and 600 mg/ml solvent/kg body weight (high dose) of ZnO NPs for 4 days. Group D (control) orally received 0.2 M sodium phosphate buffer (solvent for ZnO NPs) for the same duration. A series of neurological tests (Rota rod, open field, novel object and light-dark box test) were conducted in all groups and performance was compared between ZnO NPs treated and control group. Muscular functioning during rota rod test was significantly improved in all ZnO NPs treated mice as compared to control group. While no significant differences in open field, novel object and light-dark box test performance were observed when data from studied parameters of specific ZnO NPs treatment were compared with the control group indicating that applied doses of ZnO NPs did not affect the exploratory, anxiolytic behavior and object recognition capability of adult male albino mice.
authors.affiliation: Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, Pakistan.
authors.forename: Javeria
authors.initials: J
authors.lastname: Zahra
authors.affiliation: Institute of Pure and Applied Biology, Zoology Division, Bahauddin Zakariya University, Multan, Pakistan.
authors.forename: Shahid
authors.initials: S
authors.lastname: Iqbal
authors.affiliation: Institute of Pure and Applied Biology, Zoology Division, Bahauddin Zakariya University, Multan, Pakistan.
authors.forename: Kiran
authors.initials: K
authors.lastname: Zahra
authors.affiliation: Institute of Pure and Applied Biology, Zoology Division, Bahauddin Zakariya University, Multan, Pakistan.
authors.forename: Zulha
authors.initials: Z
authors.lastname: Javed
authors.affiliation: Department of Biochemistry, Bahauddin Zakariya University, Multan, Pakistan.
authors.forename: Muhammad Aslam
authors.initials: MA
authors.lastname: Shad
authors.affiliation: Department of Statistics, Bahauddin Zakariya University, Multan, Pakistan.
authors.forename: Atif
authors.initials: A
authors.lastname: Akbar
authors.affiliation: Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, Pakistan. naeembzu@bzu.edu.pk.
authors.forename: Muhammad Naeem
authors.initials: MN
authors.lastname: Ashiq
authors.affiliation: Institute of Pure and Applied Biology, Zoology Division, Bahauddin Zakariya University, Multan, Pakistan. furhan.iqbal@bzu.edu.pk.
authors.forename: Furhan
authors.initials: F
authors.lastname: Iqbal
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D005106:Exploratory Behavior / Q000187:drug effects* / Q000502:physiology; D008297:Male; D051379:Mice; D053758:Nanoparticles / Q000008:administration & dosage*; D021641:Recognition, Psychology / Q000187:drug effects* / Q000502:physiology; D016896:Treatment Outcome; D015034:Zinc Oxide / Q000494:pharmacology*
chemical_list: D015034:Zinc Oxide
keywords: Albino mice; Light–dark box test; Novel object recognition test; Open field test; Rota rod test; Zinc oxide