title: Development of a coumarin-furan conjugate as Zn2+ratiometric fluorescent probe in ethanol-water system.
abstract: In this study, a novel coumarin-derived compound bearing the furan moiety called 7-diethylamino-3-formylcoumarin (2'-furan formyl) hydrazone (1) has been designed, synthesized and evaluated as a Zn2+ratiometric fluorescent probe in ethanol-water system. This probe 1 showed good selectivity and high sensitivity towards Zn2+over other metal ions investigated, and a decrease in fluorescence emission intensity at 511nm accompanied by an enhancement in fluorescence emission intensity at 520nm of this probe 1 was observed in the presence of Zn2+in ethanol-water (V : V=9 : 1) solution, which provided ratiometric fluorescence detection of Zn2+. Additionally, the ratiometric fluorescence response of 1 to Zn2+was nearly completed within 0.5min, which suggested that this probe 1 could be utilized for sensing and monitoring Zn2+in environmental and biological systems for real-time detection.
authors.affiliation: College of Chemistry and Chemical Engineering, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, PR China.
authors.forename: Chao-Rui
authors.initials: CR
authors.lastname: Li
authors.affiliation: College of Chemistry and Chemical Engineering, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, PR China; School of Petrochemical Engineering, Lanzhou University of Technology, Lanzhou 730050, PR China.
authors.forename: Si-Liang
authors.initials: SL
authors.lastname: Li
authors.affiliation: College of Chemistry and Chemical Engineering, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, PR China. Electronic address: yangzy@lzu.edu.cn.
authors.forename: Zheng-Yin
authors.initials: ZY
authors.lastname: Yang
mesh_terms: D003374:Coumarins / Q000138:chemical synthesis / Q000737:chemistry*; D000431:Ethanol / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D005663:Furans / Q000138:chemical synthesis / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007477:Ions; D066244:Proton Magnetic Resonance Spectroscopy; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet; D013997:Time Factors; D014867:Water / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry*
chemical_list: D003374:Coumarins; D005456:Fluorescent Dyes; D005663:Furans; D007477:Ions; D014867:Water; D000431:Ethanol; C030123:coumarin; D015032:Zinc; C039281:furan
keywords: Coumarin; Ratiometric fluorescent probe; Selectivity; Sensitivity; Zinc ion