title: Sero-prevalence and associated factors ofHelicobacter pyloriinfection among adult patients with dyspepsia attending the gastroenterology unit in a tertiary hospital in Mwanza, Tanzania.
abstract: BACKGROUND
  Prevalence ofH.pyloriinfection varies greatly between populations in different countries. This study was conducted to determine the magnitude ofH.pyloriamong adult patients with dyspepsia attending the gastroenterology unit at Bugando medical centre.
  
  
  METHODS
  A cross sectional study involving 202 dyspeptic patients was conducted between June and July 2014. A Standardized data collection tool was used to collect socio-demographic characteristics.H.pyloriantibodies were detected using rapid immunochromatographic tests according to manufacturer's instructions.
  
  
  RESULTS
  The median age of study population was 42 (IQR: 33-54). Females 105 (51.9%) formed majority of the population studied. Of 202 participants; 119 (58.9%) were from rural areas. Seroprevalence ofH.pyloriinfection was found to be 79/202 (39.1%, 95% CI: 32.3-45.7). As the age increased the risk of havingH.pyloriinfection also increased (OR: 1.02 95% CI: 1-1.04, P=0.02). On multivariate logistic regression analysis untreated drinking water was found to predictH.pyloriseropositivity (OR: 2.33, CI: 1.09-4.96, p=0.028).
  
  
  CONCLUSIONS
  The seroprevalence ofH.pyloriamong dyspeptic patients is high in this setting. Therefore the community in Mwanza should be educated on the use of safe drinking water in order to minimizeH. pyloriinfections.
authors.affiliation: Department of Internal medicine, Weill Bugando School of Medicine, P.O.Box 1464, Mwanza, Tanzania.
authors.forename: Hyasinta
authors.initials: H
authors.lastname: Jaka
authors.affiliation: Department of Microbiology/Immunology, Weill Bugando School of Medicine, P.O.Box 1464, Mwanza, Tanzania.
authors.forename: Martha F
authors.initials: MF
authors.lastname: Mushi
authors.affiliation: Department of Microbiology/Immunology, Weill Bugando School of Medicine, P.O.Box 1464, Mwanza, Tanzania.
authors.forename: Mariam M
authors.initials: MM
authors.lastname: Mirambo
authors.affiliation: Department of Microbiology/Immunology, Weill Bugando School of Medicine, P.O.Box 1464, Mwanza, Tanzania.
authors.forename: Leonard
authors.initials: L
authors.lastname: Wilson
authors.affiliation: Department of Microbiology/Immunology, Weill Bugando School of Medicine, P.O.Box 1464, Mwanza, Tanzania.
authors.forename: Jeremiah
authors.initials: J
authors.lastname: Seni
authors.affiliation: Department of Microbiology and Immunology, Muhimbili university of Health and allied sciences P.O.Box 65001, Dar es Salaam.
authors.forename: Majigo
authors.initials: M
authors.lastname: Mtebe
authors.affiliation: Department of Microbiology/Immunology, Weill Bugando School of Medicine, P.O.Box 1464, Mwanza, Tanzania.
authors.forename: Stephen E
authors.initials: SE
authors.lastname: Mshana
mesh_terms: D000328:Adult; D015897:Comorbidity; D003430:Cross-Sectional Studies; D004415:Dyspepsia / Q000453:epidemiology*; D005260:Female; D005762:Gastroenterology; D016481:Helicobacter Infections / Q000453:epidemiology*; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016036:Seroepidemiologic Studies; D013636:Tanzania / Q000453:epidemiology; D062606:Tertiary Care Centers
keywords: H.pylori; Tanzania; dyspepsia