title: Haemodynamic coherence - The relevance of fluid therapy.
abstract: The ultimate goal of fluid therapy is to improve the oxygenation of cells by improving the cardiac output, thus improving microcirculation by optimizing macrocirculation. This haemodynamic coherence is often altered in patients with haemorrhagic shock and sepsis. The loss of haemodynamic coherence is associated with adverse outcomes. It may be influenced by the mechanisms of the underlying disease and properties of different fluids used for resuscitation in these critically ill patients. Monitoring microcirculation and haemodynamic coherence may be an additional tool to predict the response to fluid administration. In addition, microcirculatory analysis may support the clinician in his decision to not administer fluids when microcirculatory blood flow is preserved. In future, the indication, guidance and termination of fluid therapy may be assessed by bedside microvascular analysis in combination with standard haemodynamic monitoring.
authors.affiliation: Department of Anaesthesiology, Intensive Care and Pain Medicine, University Hospital of Muenster, Albert-Schweitzer-Campus 1, Building A1, 48149 Muenster, Germany. Electronic address: arnemann@anit.uni-muenster.de.
authors.forename: Philip
authors.initials: P
authors.lastname: Arnemann
authors.affiliation: Department of Anaesthesiology, Intensive Care and Pain Medicine, University Hospital of Muenster, Albert-Schweitzer-Campus 1, Building A1, 48149 Muenster, Germany. Electronic address: Laura.Seidel@ukmuenster.de.
authors.forename: Laura
authors.initials: L
authors.lastname: Seidel
authors.affiliation: Department of Anaesthesiology, Intensive Care and Pain Medicine, University Hospital of Muenster, Albert-Schweitzer-Campus 1, Building A1, 48149 Muenster, Germany. Electronic address: ertmer@anit.uni-muenster.de.
authors.forename: Christian
authors.initials: C
authors.lastname: Ertmer
mesh_terms: D016638:Critical Illness; D005440:Fluid Therapy; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D008833:Microcirculation / Q000502:physiology; D018805:Sepsis / Q000628:therapy
keywords: fluid therapy; haemodynamic coherence; haemorrhagic shock; microcirculation; resuscitation; sepsis