title: Longitudinal Growth and Neuropsychological Functioning at Age 7 in Moderate and Late Preterms.
abstract: To determine the association between longitudinal growth measures (height, weight, head circumference, and extent of catch-up growth) and neuropsychological functioning at 7 years in moderately and late preterm children.
  
  
  
  This study was part of a prospective, community-based cohort study. Data on growth were obtained from records on routine assessments in well-child centers until age 4 years and in a research setting at 7 years. Neuropsychological functioning was assessed at age 7 years. We assessed associations of growth with neuropsychological functioning and determined odds ratios for impaired neuropsychological functioning. All analyses were corrected for maternal education.
  
  
  
  We included 234 children. Median gestational age was 34 weeks (P25-75: 33-35 weeks), and mean birth weight was 2.2 kg (± 0.5 kg). Short stature at all ages was associated with poorer motor, IQ, and attention scores and led to increased risks of impaired motor skills and low IQ. Lower weight at 1 and 4 years was associated with poorer IQ scores. Increased weight gain between age 4 and 7 years was, however, associated with poorer motor, IQ, and attention scores. Decreased head circumference gain in the first year of life was associated with poorer motor and attention scores and led to an increased risk of impaired motor and attention skills.
  
  
  
  In moderately and late preterm children, poorer growth in the first 7 years is associated with poorer neuropsychological functioning. Regarding height, short stature was also associated with a higher likelihood of clinically relevant impaired neuropsychological functioning.
authors.affiliation: Division of Neonatology, Beatrix Children's Hospital, and b.m.dotinga@umcg.nl.
authors.forename: Baukje M
authors.initials: BM
authors.lastname: Dotinga
authors.affiliation: Division of Neonatology, Beatrix Children's Hospital, and.
authors.forename: Milou S
authors.initials: MS
authors.lastname: Eshuis
authors.affiliation: Division of Neonatology, Beatrix Children's Hospital, and.
authors.forename: Inger F
authors.initials: IF
authors.lastname: Bocca-Tjeertes
authors.affiliation: Division of Neonatology, Beatrix Children's Hospital, and.
authors.forename: Jorien M
authors.initials: JM
authors.lastname: Kerstjens
authors.affiliation: Division of Neonatology, Beatrix Children's Hospital, and.
authors.forename: Koenraad N J A
authors.initials: KN
authors.lastname: Van Braeckel
authors.affiliation: Department of Health Sciences, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
authors.forename: Sijmen A
authors.initials: SA
authors.lastname: Reijneveld
authors.affiliation: Division of Neonatology, Beatrix Children's Hospital, and.
authors.forename: Arend F
authors.initials: AF
authors.lastname: Bos
mesh_terms: D002648:Child; D002657:Child Development; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D008137:Longitudinal Studies; D008297:Male; D009426:Netherlands; D009483:Neuropsychological Tests / Q000706:statistics & numerical data*; D011446:Prospective Studies