title: A short history of heme dioxygenases: rise, fall and rise again.
abstract: It is well established that there are two different classes of enzymes-tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO)-that catalyse the O2-dependent oxidation of L-tryptophan to N-formylkynurenine. But it was not always so. This perspective presents a short history of the early TDO and IDO literature, the people that were involved in creating it, and the legacy that this left for the future.
authors.affiliation: Department of Chemistry, University of Leicester, University Road, Leicester, LE1 7RH, UK. emma.raven@le.ac.uk.
authors.forename: Emma L
authors.initials: EL
authors.lastname: Raven
mesh_terms: D000818:Animals; D055162:Biocatalysis; D049308:Dioxygenases / Q000378:metabolism*; D006418:Heme / Q000378:metabolism*; D006801:Humans; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism
chemical_list: D006418:Heme; D049308:Dioxygenases; D010100:Oxygen