title: The prognostic value of systemic and local inflammation in patients with laryngeal squamous cell carcinoma.
abstract: BACKGROUND
  Cancer-related systemic inflammation has been demonstrated to be associated with poor outcome in multiple types of cancers. Meanwhile, the local inflammation, which is characterized by dense intratumoral immune infiltrate, is a favorable predictor of survival outcome.
  
  
  OBJECTIVE
  To evaluate the role of systemic and local inflammation in predicting outcome in patients with laryngeal squamous cell carcinoma.
  
  
  METHODS
  In this retrospective study, 120 patients who had undergone postoperative radiotherapy were enrolled. Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), as calculated from pretreatment whole blood counts, were used to indicate systemic inflammation. The optimal cutoff values of NLR and PLR were determined using receiver operating characteristic curve analysis. Tumor infiltrating lymphocytes (TILs) density, as assessed by pathologist review of hematoxylin and eosin-stained slides, was used to represent local inflammation. Overall survival (OS) and recurrence-free survival (RFS) were assessed using the Kaplan-Meier method and multivariate Cox regression analysis.
  
  
  RESULTS
  The best cutoff was 2.79 for NLR and 112 for PLR. Kaplan-Meier analysis revealed that high NLR, high PLR, and low TILs density were significantly correlated with inferior OS and RFS, respectively (allP<0.05). The Cox proportional multivariate hazard model showed that a high pretreatment PLR and a low TILs density were both independently correlated with poor OS and RFS, respectively (allP<0.05).
  
  
  CONCLUSIONS
  Markers of systemic and local inflammation, especially PLR and TILs density, are reliable prognostic factors in patients with laryngeal squamous cell carcinoma.
authors.affiliation: Department of Radiation Oncology, Eye, Ear, Nose, and Throat Hospital, Fudan University.
authors.forename: Jie
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Radiation Oncology, Eye, Ear, Nose, and Throat Hospital, Fudan University.
authors.forename: Shengzi
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Radiation Oncology, Eye, Ear, Nose, and Throat Hospital, Fudan University.
authors.forename: Xinmao
authors.initials: X
authors.lastname: Song
authors.affiliation: Department of Pathology, Shanghai Medical School, Fudan University.
authors.forename: Wenjiao
authors.initials: W
authors.lastname: Zeng
authors.affiliation: Department of Pathology, Eye, Ear, Nose, and Throat Hospital, Fudan University, Shanghai, People's Republic of China.
authors.forename: Shuyi
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Radiation Oncology, Eye, Ear, Nose, and Throat Hospital, Fudan University.
authors.forename: Fu
authors.initials: F
authors.lastname: Chen
authors.affiliation: Department of Radiation Oncology, Eye, Ear, Nose, and Throat Hospital, Fudan University.
authors.forename: Hao
authors.initials: H
authors.lastname: Ding
keywords: laryngeal squamous cell carcinoma; neutrophil-to-lymphocyte ratio; platelet-to-lymphocyte ratio; systemic inflammation; tumor infiltrating lymphocytes