title: Effect of vitamin D on biochemical parameters in polycystic ovary syndrome women: a meta-analysis.
abstract: OBJECTIVE
  To investigate the therapeutical effect of vitamin D supplementation on the metabolism and endocrine parameters of PCOS patients.
  
  
  METHODS
  Clinical studies investigating the therapeutic effect of vitamin D supplementation on PCOS patients were selected by searching PubMed, Embase, The Cochrane library and Web of Science until April 2016. The included articles were selected according to the inclusion criteria. Serum HOMA-IR, QUICKI, LDL, DHEAS, free testosterone (FT), total testosterone (TT), PTH, 25-hydroxy-vitamin D, and triglyceride of PCOS patients were enrolled for evaluating the therapeutic effects of vitamin D.
  
  
  RESULTS
  16 studies were included in this study. There was no significant difference between the placebo group and vitamin D group in the concentration of serum 25-hydroxy-vitamin D in patients with PCOS (P = 0.06). After treated with vitamin D, the serum 25-hydroxy-vitamin D in PCOS patients was increased (P < 0.00001), while the serum PTH (P = 0.003) and triglyceride (P = 0.006) were decreased. In addition, the serum HOMA-IR, QUICKI, LDL, DHEAS, FT, and TT in PCOS patients did not change. Subgroup analysis showed that the serum triglyceride of PCOS patients was decreased by low dose of vitamin D supplementation (<50,000 IU) (P = 0.03), but no significantly changed by high-dose vitamin D supplementation (≥50,000 IU) (P = 0.17).
  
  
  CONCLUSIONS
  Vitamin D supplementation significantly attenuates serum PTH and triglyceride in PCOS patients except for serum HOMA-IR, QUICKI, LDL, DHEAS, FT, and TT. Furthermore, less than 50,000 IU vitamin D supplementation is sufficient for decreasing serum triglyceride.
authors.affiliation: Department of Gynecology, Nanjing Maternity and Child Health Care Hospital, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, 123 Mochou Road, 210004, Nanjing, Jiangsu Province, China.
authors.forename: Yunping
authors.initials: Y
authors.lastname: Xue
authors.affiliation: Department of Health Medical Institute, Nanjing Maternity and Child Health Care Hospital, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, 210004, Nanjing, China.
authors.forename: Pengfei
authors.initials: P
authors.lastname: Xu
authors.affiliation: Department of Gynecology, Nanjing Maternity and Child Health Care Hospital, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, 123 Mochou Road, 210004, Nanjing, Jiangsu Province, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Xue
authors.affiliation: Department of Gynecology, Nanjing Maternity and Child Health Care Hospital, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, 123 Mochou Road, 210004, Nanjing, Jiangsu Province, China.
authors.forename: Xiaoyi
authors.initials: X
authors.lastname: Duan
authors.affiliation: Department of Gynecology, Nanjing Maternity and Child Health Care Hospital, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, 123 Mochou Road, 210004, Nanjing, Jiangsu Province, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Cao
authors.affiliation: Department of Gynecology, Nanjing Maternity and Child Health Care Hospital, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, 123 Mochou Road, 210004, Nanjing, Jiangsu Province, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Luan
authors.affiliation: Department of Gynecology, Nanjing Maternity and Child Health Care Hospital, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, 123 Mochou Road, 210004, Nanjing, Jiangsu Province, China. lq_clarinet@foxmail.com.
authors.forename: Qian
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Gynecology, Nanjing Maternity and Child Health Care Hospital, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, 123 Mochou Road, 210004, Nanjing, Jiangsu Province, China. m15951750181@163.com.
authors.forename: Lin
authors.initials: L
authors.lastname: Gu
mesh_terms: D019587:Dietary Supplements; D005260:Female; D006801:Humans; D010281:Parathyroid Hormone / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D013739:Testosterone / Q000097:blood; D014280:Triglycerides / Q000097:blood; D014807:Vitamin D / Q000008:administration & dosage* / Q000031:analogs & derivatives / Q000097:blood
chemical_list: D010281:Parathyroid Hormone; D014280:Triglycerides; D014807:Vitamin D; D013739:Testosterone; C104450:25-hydroxyvitamin D
keywords: 25-hydroxy-vitamin D3; Calcitriol; Cholecalciferol; Polycystic ovary syndrome (PCOS); Vitamin D supplementation