title: Progressive Aortic Stenosis in Homozygous Familial Hypercholesterolemia After Liver Transplant.
abstract: Early onset coronary artery disease and aortic calcifications are characteristic features of patients with homozygous familial hypercholesterolemia. Standard medical therapy includes dietary modification, pharmacotherapy, and lipoprotein apheresis to lower serum low-density lipoprotein cholesterol (LDL-C). Liver transplant is a surgical option for the treatment of homozygous familial hypercholesterolemia and can lead to normal cholesterol levels. Vascular calcifications are known to progress despite standard medical therapy and have been reported after liver transplant in the setting of rejection. We present the first report of progressive severe aortic valve stenosis in a patient despite liver transplant with normalization of lipid levels and no history of graft rejection.
authors.affiliation: Divisions of Cardiology and jdrobinson@luriechildrens.org.|Departments of Pediatrics.
authors.forename: Margaret
authors.initials: M
authors.lastname: Greco
authors.affiliation: Divisions of Cardiology and.|Departments of Pediatrics.|Radiology, and.
authors.forename: Joshua D
authors.initials: JD
authors.lastname: Robinson
authors.affiliation: Cardiothoracic Surgery, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois; and.|Surgery, Northwestern University Feinberg School of Medicine, Chicago Illinois.
authors.forename: Osama
authors.initials: O
authors.lastname: Eltayeb
authors.affiliation: Divisions of Cardiology and.|Departments of Pediatrics.
authors.forename: Irwin
authors.initials: I
authors.lastname: Benuck
mesh_terms: D001021:Aortic Valve / Q000601:surgery; D001024:Aortic Valve Stenosis / Q000601:surgery*; D002648:Child; D001026:Coronary Artery Bypass; D023921:Coronary Stenosis / Q000000981:diagnostic imaging / Q000601:surgery; D018450:Disease Progression; D006350:Heart Valve Prosthesis; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000150:complications*; D016031:Liver Transplantation; D008297:Male