title: The Role of Cytokines in the Development of Atherosclerosis.
abstract: Atherosclerosis contributes to the development of many cardiovascular diseases, which remain the leading cause of death in developed countries. Atherosclerosis is a chronic inflammatory disease of large and medium-sized arteries. It is caused by dyslipidemia and mediated by both innate and adaptive immune responses. Inflammation is a key factor at all stages of atherosclerosis progression. Cells involved in pathogenesis of atherosclerosis were shown to be activated by soluble factors, cytokines, that strongly influence the disease development. Pro-inflammatory cytokines accelerate atherosclerosis progression, while anti-inflammatory cytokines ameliorate the disease. In this review, we discuss the latest findings on the role of cytokines in the development and progression of atherosclerosis.
authors.affiliation: Fox Chase Cancer Center, Philadelphia, PA, USA. Ekaterina.Koltsova@fccc.edu.
authors.forename: A R
authors.initials: AR
authors.lastname: Fatkhullina
authors.forename: I O
authors.initials: IO
authors.lastname: Peshkova
authors.forename: E K
authors.initials: EK
authors.lastname: Koltsova
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D050197:Atherosclerosis / Q000276:immunology* / Q000473:pathology; D002908:Chronic Disease; D016207:Cytokines / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate
chemical_list: D016207:Cytokines