title: [Cardiovascular diseases and cancer incidence in general population: results from MATISS cohort].
abstract: OBJECTIVE
  to assess the incidence of fatal and non-fatal major cardiovascular diseases and cancers in people with different cardiovascular risk profile of a longitudinal cohort.
  
  
  METHODS
  longitudinal study carried out in a large sample of general population, with a median follow-up of 17.7 years.
  
  
  METHODS
  MATISS longitudinal cohort, 7,491 men and women aged 20-75 years, free of cancer or cardiovascular diseases at baseline. Two cardiovascular risk groups (low-intermediate cardiovascular risk and high cardiovascular risk) and two educational levels (low level: primary school; middle/high level: middle/high school, university) have been considered.
  
  
  METHODS
  for both cancer and cardiovascular events the standardized incidence rates have been calculated, taking into account the cardiovascular risk profile and the educational level.
  
  
  RESULTS
  people with a high-risk profile have higher incidence of major cardiovascular diseases and cancers. Furthermore, incidence rates are higher in people with lower educational level, except for cardiovascular diseases in men.
  
  
  CONCLUSIONS
  this study shows that, in the considered population, cancer incidence rates are higher than cardiovascular diseases rates; moreover, cancer incidence is higher in people with high-risk cardiovascular profile. The increase of prevalence of favourable risk profile in the general population could represent effective community strategies for prevention of cardiovascular diseases and cancer. Major attention should be dedicated towards people at lower socioeconomical level.
authors.affiliation: Dipartimento di sanità pubblica e malattie infettive, Sapienza Università di Roma.
authors.forename: Simona Carmen
authors.initials: SC
authors.lastname: Ursu
authors.affiliation: Unità operativa complessa, Registro tumori, Latina.
authors.forename: Fabio
authors.initials: F
authors.lastname: Pannozzo
authors.affiliation: Centro nazionale di epidemiologia, sorveglianza e promozione della salute (CNESPS), Istituto superiore di sanità, Roma.
authors.forename: Luigi
authors.initials: L
authors.lastname: Palmieri
authors.affiliation: Dipartimento di sanità pubblica e malattie infettive, Sapienza Università di Roma.
authors.forename: Annarita
authors.initials: A
authors.lastname: Vestri
authors.affiliation: Centro nazionale di epidemiologia, sorveglianza e promozione della salute (CNESPS), Istituto superiore di sanità, Roma.
authors.forename: Cinzia
authors.initials: C
authors.lastname: Lo Noce
authors.affiliation: Centro nazionale di epidemiologia, sorveglianza e promozione della salute (CNESPS), Istituto superiore di sanità, Roma. simona.giampaoli@iss.it.
authors.forename: Simona
authors.initials: S
authors.lastname: Giampaoli
mesh_terms: D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000150:complications / Q000453:epidemiology* / Q000517:prevention & control; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications / Q000453:epidemiology* / Q000517:prevention & control; D011203:Poverty / Q000706:statistics & numerical data*; D015995:Prevalence; D012307:Risk Factors