title: Febrile Neutropenia with Thrombocytopenia after Infliximab Induction in a Patient with Ulcerative Colitis.
abstract: A 34-year-old female with left-sided ulcerative colitis (UC) developed severe febrile neutropenia/thrombocytopenia soon after infliximab induction therapy. There was no other plausible cause of the cell line abnormalities other than an accurate temporal association with infliximab administration. Supportive care, broad-spectrum antibiotic, and single dose of filgrastim was given on day 5 of admission due to persistently low absolute neutrophil count and fevers. The cell lines recovered, fever resolved and the patient made a complete clinical recovery. Clinicians should be aware of this potential life-threatening inflixmab side effect previously unreported in adults with UC.
authors.affiliation: Division of Gastroenterology, Hepatology and Nutrition, Allegheny Health Network, Pittsburgh, Pa., USA.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Gomez
authors.affiliation: Department of Internal Medicine, Allegheny Health Network, Pittsburgh, Pa., USA.
authors.forename: Shifa
authors.initials: S
authors.lastname: Umar
authors.affiliation: Department of Internal Medicine, Allegheny Health Network, Pittsburgh, Pa., USA.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Bilal
authors.affiliation: Division of Gastroenterology, Hepatology and Nutrition, Allegheny Health Network, Pittsburgh, Pa., USA.
authors.forename: Cristina
authors.initials: C
authors.lastname: Strahotin
authors.affiliation: Division of Gastroenterology, Hepatology and Nutrition, Allegheny Health Network, Pittsburgh, Pa., USA.
authors.forename: Kofi
authors.initials: K
authors.lastname: Clarke
keywords: Febrile neutropenia; Infliximab; Thrombocytopenia; Ulcerative colitis