title: Uveitic Glaucoma: Long-term Clinical Outcome and Risk Factors for Progression.
abstract: OBJECTIVE
  To study the long-term clinical outcomes of uveitic glaucoma and to identify risk factors for progression.
  
  
  METHODS
  Retrospective study of uveitic glaucoma patients in two tertiary medical centers in 2003-2015. Patient- and disease-related data was retrieved. Clinical parameters and visual fields measured at predetermined time points were recorded. Outcome measures included maintaining intraocular pressure ≤21 mmHg and preserving visual fields.
  
  
  RESULTS
  Included were 34 patients (53 eyes), with a mean follow-up of 7 years. Idiopathic anterior uveitis and open-angle glaucoma were most common. In total, 62% of eyes were steroid responders. Higher IOP was associated with posterior synechiae, peripheral-anterior synechiae, steroidal, and immunomodulatory therapy (p<0.05). Glaucomatous field defects developed in 49%, with most showing no progression, despite elevation of cup-to-disc ratio (p<0.05).
  
  
  CONCLUSIONS
  Chronic severe uveitis, expressed by structural complications and immunomodulatory therapy, was associated with high IOP and the need for more IOP lowering medications, but was unrelated to glaucomatous damage.
authors.affiliation: a Department of Ophthalmology , Rabin Medical Center, Beilinson Hospital , Petach Tikva , Israel.
authors.forename: Yael
authors.initials: Y
authors.lastname: Sharon
authors.affiliation: b Pediatric Ophthalmology Unit , Schneider Children's Medical Center of Israel , Petach Tikva , Israel.|c Sackler Faculty of Medicine , Tel Aviv University , Tel Aviv , Israel.
authors.forename: Ronit
authors.initials: R
authors.lastname: Friling
authors.affiliation: a Department of Ophthalmology , Rabin Medical Center, Beilinson Hospital , Petach Tikva , Israel.|c Sackler Faculty of Medicine , Tel Aviv University , Tel Aviv , Israel.
authors.forename: Moshe
authors.initials: M
authors.lastname: Luski
authors.affiliation: d Department of Ophthalmology , Hadassah University Hospital , Jerusalem , Israel.
authors.forename: Belén Quizhpe
authors.initials: BQ
authors.lastname: Campoverde
authors.affiliation: d Department of Ophthalmology , Hadassah University Hospital , Jerusalem , Israel.
authors.forename: Radgonde
authors.initials: R
authors.lastname: Amer
authors.affiliation: a Department of Ophthalmology , Rabin Medical Center, Beilinson Hospital , Petach Tikva , Israel.|c Sackler Faculty of Medicine , Tel Aviv University , Tel Aviv , Israel.
authors.forename: Michal
authors.initials: M
authors.lastname: Kramer
mesh_terms: D002648:Child; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D005901:Glaucoma / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000188:drug therapy; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome; D014605:Uveitis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D014792:Visual Acuity / Q000187:drug effects; D014794:Visual Fields / Q000187:drug effects
chemical_list: D005938:Glucocorticoids
keywords: Clinical outcome; risk factors; secondary glaucoma; uveitis; visual field