title: Understanding How Smoking Increases Cancer Risk.
abstract: An in-depth computational analysis is helping to unravel the molecular mechanisms by which smoking increases the likelihood of cancer. The researchers uncovered several distinct smoking-related mutational signatures, including one thought to be the direct consequence of replicating carcinogen-damaged DNA, and another that may result in a normal clocklike mutational process being sped up.
mesh_terms: D019175:DNA Methylation; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study / Q000379:methods; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA / Q000379:methods; D012907:Smoking / Q000009:adverse effects*