title: Does cell phone use increase the chances of parotid gland tumor development? A systematic review and meta-analysis.
abstract: BACKGROUND
  Prior epidemiological studies had examined the association between cell phone use and the development of tumors in the parotid glands. However, there is no consensus about the question of whether cell phone use is associated with increased risk of tumors in the parotid glands. We performed a meta-analysis to evaluate the existing literature about the mean question and to determine their statistical significance.
  
  
  METHODS
  Primary association studies. Papers that associated cell phone use and parotid gland tumors development were included, with no restrictions regarding publication date, language, and place of publication. Systematic literature search using PubMed, SciELO and Embase followed by meta-analysis.
  
  
  CONCLUSIONS
  Initial screening included 37 articles, and three were included in meta-analysis. Using three independent samples including 5087 subjects from retrospective case-control studies, cell phone use seems to be associated with greater odds (1.28, 95%- confidence interval: 1.09-1.51) to develop salivary gland tumor. Results should be read with caution due to the limited number of studies available and their retrospective design.
authors.affiliation: Department of Pathology, Biological Sciences Institute, Universidade Federal de Minas Gerais- UFMG, Belo Horizonte, Brazil.
authors.forename: Elisa Carvalho
authors.identifier: http://orcid.org/0000-0002-3005-1736
authors.initials: EC
authors.lastname: de Siqueira
authors.affiliation: Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais- UFMG, Belo Horizonte, Brazil.
authors.forename: Fabrício Tinoco Alvim
authors.initials: FTA
authors.lastname: de Souza
authors.affiliation: Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais- UFMG, Belo Horizonte, Brazil.
authors.forename: Ricardo Santiago
authors.initials: RS
authors.lastname: Gomez
authors.affiliation: Department of Pathology, Biological Sciences Institute, Universidade Federal de Minas Gerais- UFMG, Belo Horizonte, Brazil.
authors.forename: Carolina Cavalieri
authors.initials: CC
authors.lastname: Gomes
authors.affiliation: Grupo de Pesquisa em Bioestatística e Epidemiologia Molecular, Department of General Biology, Biological Sciences Institute, Universidade Federal de Minas Gerais- UFMG, Belo Horizonte, Brazil.
authors.forename: Renan Pedra
authors.initials: RP
authors.lastname: de Souza
mesh_terms: D000075782:Cell Phone Use / Q000009:adverse effects*; D006801:Humans; D016017:Odds Ratio; D010307:Parotid Neoplasms / Q000453:epidemiology*; D012107:Research Design; D012307:Risk Factors
keywords: cell phone; meta-analysis; non-ionizing radiation; parotid gland; systematic review