title: Metabolic Changes in the Bilateral Visual Cortex of the Monocular Blind Macaque: A Multi-Voxel Proton Magnetic Resonance Spectroscopy Study.
abstract: The metabolic changes accompanied with adaptive plasticity in the visual cortex after early monocular visual loss were unclear. In this study, we detected the metabolic changes in bilateral visual cortex of normal (group A) and monocular blind macaque (group B) for studying the adaptive plasticity using multi-voxel proton magnetic resonance spectroscopy (1H-MRS) at 32 months after right optic nerve transection. Then, we compared the N-Acetyl aspartate (NAA)/Creatine (Cr), myoinositol (Ins)/Cr, choline (Cho)/Cr and Glx (Glutamate + glutamine)/Cr ratios in the visual cortex between two groups, as well as between the left and right visual cortex of group A and B. Compared with group A, in the bilateral visual cortex, a decreased NAA/Cr and Glx/Cr ratios in group B were found, which was more clearly in the right visual cortex; whereas the Ins/Cr and Cho/Cr ratios of group B were increased. All of these findings were further confirmed by immunohistochemical staining. In conclusion, the difference of metabolic ratios can be detected by multi-voxel1H-MRS in the visual cortex between groups A and B, which was valuable for investigating the adaptive plasticity of monocular blind macaque.
authors.affiliation: Otorhinolaryngology Department of Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China.
authors.forename: Lingjie
authors.initials: L
authors.lastname: Wu
authors.affiliation: Department of Radiology, Eye and ENT Hospital of Shanghai Medical School, Fudan University, 83 Fenyang Rd, Shanghai, 200031, China. tzh518sunny@163.com.
authors.forename: Zuohua
authors.identifier: http://orcid.org/0000-0003-4687-5905
authors.initials: Z
authors.lastname: Tang
authors.affiliation: Department of Radiology, Huashan Hospital of Shanghai Medical School, Fudan University, 12 Wulumuqi Rd, Shanghai, China. xyfeng@shmu.edu.cn.
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Feng
authors.affiliation: State Key Laboratory of Medical Neurobiology, Department of Ophthalmology, Eye and ENT Hospital, Institutes of Brain Science, Fudan University, Shanghai, China.
authors.forename: Xinghuai
authors.initials: X
authors.lastname: Sun
authors.affiliation: Department of Radiology, Eye and ENT Hospital of Shanghai Medical School, Fudan University, 83 Fenyang Rd, Shanghai, 200031, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Qian
authors.affiliation: Department of Radiotherapy, Eye and ENT Hospital of Shanghai Medical School, Fudan University, Shanghai, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Wang
authors.affiliation: Siemens Ltd. Healthcare Sector, Shanghai, China.
authors.forename: Lixin
authors.initials: L
authors.lastname: Jin
authors.affiliation: Department of Radiology, Eye and ENT Hospital of Shanghai Medical School, Fudan University, 83 Fenyang Rd, Shanghai, 200031, China.|Department of Radiology, Jinshan Hospital of Shanghai Medical School, Fudan University, Shanghai, China.
authors.forename: Jingxuan
authors.initials: J
authors.lastname: Jiang
authors.affiliation: Department of Radiology, Eye and ENT Hospital of Shanghai Medical School, Fudan University, 83 Fenyang Rd, Shanghai, 200031, China.|Department of Radiology, Jinshan Hospital of Shanghai Medical School, Fudan University, Shanghai, China.
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Zhong
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D008251:Macaca; D066244:Proton Magnetic Resonance Spectroscopy / Q000379:methods*; D011897:Random Allocation; D015349:Vision, Monocular / Q000502:physiology*; D014793:Visual Cortex / Q000378:metabolism*
keywords: Haplorhini and blindness; Macaca; Magnetic resonance spectroscopy