title: Leptin in inflammation and autoimmunity.
abstract: After its discovery as a key controller of metabolic function, leptin has been later extensively implicated in additional functions including important modulatory activities on the innate and adaptive immune response. This review analyzes the known implications of leptin in multiple inflammatory conditions, including autoimmune diseases, and how this knowledge could be instrumental in the design of leptin-based manipulation strategies to help restoration of abnormal immune responses.
authors.affiliation: Department of Medicine, University of California Los Angeles, 1000 Veteran Ave. 32-59, Los Angeles, CA 90095, United States. Electronic address: alacava@mednet.ucla.edu.
authors.forename: Antonio
authors.initials: A
authors.lastname: La Cava
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D015551:Autoimmunity; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000276:immunology* / Q000503:physiopathology; D020738:Leptin / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D051379:Mice; D009765:Obesity / Q000378:metabolism / Q000503:physiopathology
chemical_list: D020738:Leptin
keywords: Autoimmunity; Inflammation; Leptin