title: Three New Iridoid Glycosides from the Aerial Parts of Asperula involucrata.
abstract: Three new iridoid glycosides, named involucratosides A - C (1 - 3), were isolated from the H2O subextract of crude MeOH extract prepared from the aerial parts of Asperula involucrata along with a known iridoid glycoside (adoxoside), three flavone glycosides (apigenin 7-O-β-glucopyranoside, luteolin 7-O-β-glucopyranoside, apigenin 7-O-rutinoside) as well as two phenolic acid derivatives (chlorogenic acid and ferulic acid 4-O-β-glucopyranoside). Their chemical structures were established by UV, IR, 1D- (1H,13C and JMOD) and 2D- (COSY, HSQC, HMBC and NOESY) NMR experiments and HR-ESI-MS. In addition, the crude extract, subextracts and isolates were evaluated for their xanthine oxidase inhibitory and antioxidant activities in in vitro tests. This is the first report on the chemical composition and bioactivities of A. involucrata.
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Yeditepe University, TR-34755, Kayışdağı, İstanbul, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Kırmızıbekmez
authors.affiliation: Faculty of Pharmacy, Yeditepe University, TR-34755, Kayışdağı, İstanbul, Turkey.
authors.forename: Kubilay
authors.initials: K
authors.lastname: Tiftik
authors.affiliation: Institute of Pharmacognosy, University of Szeged, Eötvös u 6, H-6720, Szeged, Hungary.
authors.forename: Norbert
authors.initials: N
authors.lastname: Kúsz
authors.affiliation: Institute of Pharmacognosy, University of Szeged, Eötvös u 6, H-6720, Szeged, Hungary.
authors.forename: Orsolya
authors.initials: O
authors.lastname: Orban-Gyapai
authors.affiliation: Institute of Pharmacognosy, University of Szeged, Eötvös u 6, H-6720, Szeged, Hungary.
authors.forename: Zoltán Péter
authors.initials: ZP
authors.lastname: Zomborszki
authors.affiliation: Institute of Pharmacognosy, University of Szeged, Eötvös u 6, H-6720, Szeged, Hungary.|Interdisciplinary Centre of Natural Products, University of Szeged, Eötvös u. 6., H-6720, Szeged, Hungary.
authors.forename: Judit
authors.initials: J
authors.lastname: Hohmann
mesh_terms: D000975:Antioxidants / Q000737:chemistry; D057889:Iridoid Glycosides / Q000737:chemistry* / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D035261:Plant Components, Aerial / Q000737:chemistry / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry; D011485:Protein Binding; D019666:Rubiaceae / Q000737:chemistry* / Q000378:metabolism; D021241:Spectrometry, Mass, Electrospray Ionization; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D000975:Antioxidants; D057889:Iridoid Glycosides; D010936:Plant Extracts; C000616372:involucratoside A; C000616373:involucratoside B; C000616374:involucratoside C; D014969:Xanthine Oxidase
keywords: 
  Asperula involucrata
  ; Antioxidant activities; Involucratosides A - C; Iridoid glycosides; Rubiaceae; Xanthine oxidase inhibitory activities