title: Platelets in liver and renal disease.
abstract: This review will discuss how 2 common and morbid conditions, renal disease and liver disease, alter platelet number and function. It will review the impact of thrombocytopenia on bleeding complications in patients with these disorders and whether the low platelet count actually correlates with bleeding risk. Emerging data also suggest that platelets are much more than bystanders in both renal and liver disease, but instead play an active role in the pathobiology of these disorders. This review will briefly cover the emerging information on novel roles of platelets in the biology of renal and liver disease.
authors.affiliation: Divisions of Hematology, Departments of Pediatrics, The Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
authors.forename: Michele P
authors.initials: MP
authors.lastname: Lambert
mesh_terms: D001792:Blood Platelets / Q000378:metabolism*; D006470:Hemorrhage / Q000097:blood / Q000209:etiology / Q000628:therapy; D006801:Humans; D007674:Kidney Diseases / Q000097:blood / Q000150:complications / Q000628:therapy; D008107:Liver Diseases / Q000097:blood / Q000151:congenital / Q000628:therapy; D013921:Thrombocytopenia / Q000097:blood / Q000209:etiology / Q000628:therapy