title: Identification of a CD133-CD55- population functions as a fetal common skeletal progenitor.
abstract: In this study, we identified a CD105+CD90.1-CD133-CD55- (CD133-CD55-) population in the fetal skeletal element that can generate bone and bone marrow. Besides osteoblasts and chondrocytes, the CD133-CD55- common progenitors can give rise to marrow reticular stromal cells and perivascular mesenchymal progenitors suggesting they function as the fetal common skeletal progenitor. Suppression of CXCL12 and Kitl expression in CD133-CD55- common progenitors severely disrupted the BM niche formation but not bone generation. Thus, CD133-CD55- common progenitors are the main source of CXCL12 and Kitl producing cells in the developing marrow.
authors.affiliation: Divison of Hematopoietic Stem Cell and Leukemia Research, Gehr Family Center for Leukemia Research, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.|Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA 91010, USA.|Departments of Cancer Immunotherapeutic and Immunology, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.
authors.forename: Lihong
authors.initials: L
authors.lastname: Weng
authors.affiliation: Divison of Hematopoietic Stem Cell and Leukemia Research, Gehr Family Center for Leukemia Research, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.|Department of Transfusion Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an 7100032, P.R. China.
authors.forename: Xingbin
authors.initials: X
authors.lastname: Hu
authors.affiliation: Divison of Hematopoietic Stem Cell and Leukemia Research, Gehr Family Center for Leukemia Research, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.|Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA 91010, USA.
authors.forename: Bijender
authors.initials: B
authors.lastname: Kumar
authors.affiliation: Divison of Hematopoietic Stem Cell and Leukemia Research, Gehr Family Center for Leukemia Research, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.|Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA 91010, USA.
authors.forename: Mayra
authors.initials: M
authors.lastname: Garcia
authors.affiliation: Department of Diabetes and Metabolic Diseases Research, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.
authors.forename: Ivan
authors.initials: I
authors.lastname: Todorov
authors.affiliation: Divison of Hematopoietic Stem Cell and Leukemia Research, Gehr Family Center for Leukemia Research, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.
authors.forename: Xiaoman
authors.initials: X
authors.lastname: Jung
authors.affiliation: Divison of Hematopoietic Stem Cell and Leukemia Research, Gehr Family Center for Leukemia Research, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.|Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA 91010, USA.
authors.forename: Guido
authors.initials: G
authors.lastname: Marcucci
authors.affiliation: Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA 91010, USA.|Departments of Cancer Immunotherapeutic and Immunology, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.|Irell &Manella Graduate School of Biological Sciences, City of Hope, Duarte, CA 91010, USA.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Forman
authors.affiliation: Divison of Hematopoietic Stem Cell and Leukemia Research, Gehr Family Center for Leukemia Research, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.|Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA 91010, USA.|Irell &Manella Graduate School of Biological Sciences, City of Hope, Duarte, CA 91010, USA.
authors.forename: Ching-Cheng
authors.initials: CC
authors.lastname: Chen
mesh_terms: D000071916:AC133 Antigen / Q000378:metabolism*; D000818:Animals; D000067696:Ataxin-1 / Q000378:metabolism; D015415:Biomarkers; D001853:Bone Marrow / Q000378:metabolism; D018958:CD55 Antigens / Q000378:metabolism*; D002454:Cell Differentiation; D054377:Chemokine CXCL12 / Q000378:metabolism; D019902:Chondrocytes / Q000378:metabolism; D003114:Colony-Forming Units Assay; D016130:Immunophenotyping; D051379:Mice; D018345:Mice, Knockout; D010006:Osteoblasts / Q000166:cytology / Q000378:metabolism*; D010012:Osteogenesis; D010641:Phenotype; D055153:Stem Cell Niche
chemical_list: D000071916:AC133 Antigen; D000067696:Ataxin-1; D015415:Biomarkers; D018958:CD55 Antigens; D054377:Chemokine CXCL12