title: Brief Report: Increased Frequency of CD39+ CD56bright Natural Killer Cells in HIV-1 Infection Correlates With Immune Activation and Disease Progression.
abstract: The expression pattern of the ectonucleotidases CD39 and CD73 on natural killer (NK) cells was examined in peripheral blood mononuclear cell of 61 HIV-1-infected patients. Increased frequencies of CD39CD56 NK cells were detectable in untreated HIV patients, which was associated with high viral load, low CD4 T-cell count, and CD8 T-cell activation. Additionally, levels of CD39 on NK cells were inducible by in vitro stimulation of NK cells, correlating with aryl hydrocarbon receptor and interleukin 10 expression. Here, we provide the first evidence of increased CD39CD56 NK cell frequencies during HIV infection, which might have consequences for NK cell function and HIV pathogenesis.
authors.affiliation: *I. Department of Medicine, Section Infectious Diseases, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; †Heinrich Pette Institute-Leibniz Institute for Experimental Virology, Virus Immunology Unit Hamburg, Germany; ‡ViiV Healthcare, Brentford, United Kingdom; and §DZIF Partner Site (German Center for Infection Research), Hamburg, Germany.
authors.forename: Patrick
authors.initials: P
authors.lastname: Dierks
authors.forename: Raluca
authors.initials: R
authors.lastname: Wroblewski
authors.forename: Johanna M
authors.initials: JM
authors.lastname: Eberhard
authors.forename: Gloria
authors.initials: G
authors.lastname: Martrus
authors.forename: Olaf
authors.initials: O
authors.lastname: Degen
authors.forename: Sandra
authors.initials: S
authors.lastname: Hertling
authors.forename: Stefan
authors.initials: S
authors.lastname: Schmiedel
authors.forename: Sebastian
authors.initials: S
authors.lastname: Lunemann
authors.forename: Anja
authors.initials: A
authors.lastname: Hüfner
authors.forename: Ansgar W
authors.initials: AW
authors.lastname: Lohse
authors.forename: Marcus
authors.initials: M
authors.lastname: Altfeld
authors.forename: Jan
authors.initials: J
authors.lastname: van Lunzen
authors.forename: Julian
authors.initials: J
authors.lastname: Schulze Zur Wiesch
mesh_terms: D015703:Antigens, CD / Q000378:metabolism*; D001081:Apyrase / Q000378:metabolism*; D019002:CD56 Antigen / Q000378:metabolism*; D018450:Disease Progression; D015658:HIV Infections / Q000276:immunology* / Q000503:physiopathology; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology*; D016133:Polymerase Chain Reaction; D019562:Viral Load
chemical_list: D015703:Antigens, CD; D019002:CD56 Antigen; C522918:NCAM1 protein, human; D001081:Apyrase; C067869:CD39 antigen