title: Mature aggressive B-cell lymphoma across age groups - molecular advances and therapeutic implications.
abstract: Mature B-cell lymphoma represents the most common type of Non-Hodgkin lymphoma, and different subtypes prevail at different patient ages. Areas covered: We review recent data on differences and commonalities in mature B-cell lymphoma occurring in adult and pediatric patients, with a special emphasis on molecular advances and therapeutic implications. To this end, we will discuss knowledge on diffuse large B-cell lymphoma and Burkitt lymphoma/leukemia, which are the most frequent subtypes in adult and pediatric patients, respectively, and on primary mediastinal B-cell lymphoma, which is a subtype of mature B-cell lymphoma occurring mainly in adolescents and young adults with a female predominance. Expert commentary: Molecular profiling has revealed molecular alterations that can be used to further classify the subtypes of mature B-cell lymphoma. These new subgroups frequently respond differentially to targeted therapeutic strategies. Future clinical trials utilizing new drugs will address this issue by combining clinical data and response assessment with a molecular workup of the corresponding lymphomas.
authors.affiliation: a Pediatric Hematology and Oncology , University Hospital Muenster , Muenster , Germany.|b Translational Oncology, Department of Medicine A , University Hospital Muenster, Muenster, Germany; Cluster of Excellence EXC 1003, Cells in Motion , Muenster , Germany.
authors.forename: Jonas
authors.initials: J
authors.lastname: Lange
authors.affiliation: b Translational Oncology, Department of Medicine A , University Hospital Muenster, Muenster, Germany; Cluster of Excellence EXC 1003, Cells in Motion , Muenster , Germany.
authors.forename: Georg
authors.initials: G
authors.lastname: Lenz
authors.affiliation: a Pediatric Hematology and Oncology , University Hospital Muenster , Muenster , Germany.
authors.forename: Birgit
authors.initials: B
authors.lastname: Burkhardt
mesh_terms: D000367:Age Factors; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D018450:Disease Progression; D006801:Humans; D016393:Lymphoma, B-Cell / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology / Q000628:therapy*; D060787:Neoplasm Grading; D011379:Prognosis; D059039:Standard of Care; D016896:Treatment Outcome
keywords: Mature B-cell lymphoma; demographic factors; molecular profiling; targeted therapies; treatment optimization