title: The Optical Coherence Tomographic Profile of Leber Hereditary Optic Neuropathy.
abstract: The objective of this study was to describe the changes in the retinal ganglion cell complex (GCC) relative to the retinal nerve fibre layer (RNFL) over time in Leber hereditary optic neuropathy (LHON) patients. Average RNFL and GCC thickness was measured in seven patients in the early acute (123, 68.4 μm), late acute (113.5, 57.4 μm), and chronic (72.7, 50.8 μm) phases. Patients showed thinning of the GCC with RNFL swelling in the early acute phase. GCC thinning became severe within weeks and persisted. RNFL swelling normalised during the late acute phase with eventual thinning in the chronic phase. GCC changes appear at the commencement of visual loss and in some cases prior to vision loss. These findings define an optical coherence tomography (OCT) profile in LHON.
authors.affiliation: New England Eye Center, Tufts Medical Center, Tufts University , Boston, Massachusetts, USA.
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Hedges
authors.affiliation: New England Eye Center, Tufts Medical Center, Tufts University , Boston, Massachusetts, USA.
authors.forename: Marisa
authors.initials: M
authors.lastname: Gobuty
authors.affiliation: New England Eye Center, Tufts Medical Center, Tufts University , Boston, Massachusetts, USA.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Manfready
authors.affiliation: New England Eye Center, Tufts Medical Center, Tufts University , Boston, Massachusetts, USA.
authors.forename: Natalie
authors.initials: N
authors.lastname: Erlich-Malona
authors.affiliation: New England Eye Center, Tufts Medical Center, Tufts University , Boston, Massachusetts, USA.
authors.forename: Caitlin
authors.initials: C
authors.lastname: Monaco
authors.affiliation: New England Eye Center, Tufts Medical Center, Tufts University, Boston, Massachusetts, USA; Dysautonomia Center, Department of Neurology, New York University School of Medicine, New York, New York, USA; Department of Ophthalmology, Pontifical Catholic University of Chile, Santiago de Chile, Chile.
authors.forename: Carlos E
authors.initials: CE
authors.lastname: Mendoza-Santiesteban
keywords: Ganglion cell complex; Leber hereditary optic neuropathy; optical coherence tomography; retinal nerve fibre layer