title: Synthetic Approach to the Core Structure of Oleandrin and Related Cardiac Glycosides with Highly Functionalized Ring D.
abstract: The first synthetic approach to the core structure of cardiac glycoside oleandrin exhibiting a potent cytotoxic activity, starting from a common androstane derivative, has been accomplished. The synthesis is focused on stereoselective transformations in the densely substituted and sterically shielded five-membered ring (steroid ring D). The developed synthesis paves a route to the synthesis of related bufadienolides, i.e., constituents of traditional drug Ch'an Su, bufotalin, and cinobufagin.
authors.affiliation: Institute of Organic Chemistry, Polish Academy of Sciences , Ul. Marcina Kasprzaka 44/52, 01-224 Warsaw, Poland.
authors.forename: Karol
authors.initials: K
authors.lastname: Michalak
authors.affiliation: Institute of Organic Chemistry, Polish Academy of Sciences , Ul. Marcina Kasprzaka 44/52, 01-224 Warsaw, Poland.
authors.forename: Maja
authors.initials: M
authors.lastname: Morawiak
authors.affiliation: Institute of Organic Chemistry, Polish Academy of Sciences , Ul. Marcina Kasprzaka 44/52, 01-224 Warsaw, Poland.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Wicha