title: Natural Products with Anti-obesity Effects and Different Mechanisms of Action.
abstract: Obesity, a primary influence on health condition, causes numerous comorbidities and complications and, therefore, pharmacotherapy is considered a strategy for its treatment. However, the adverse effects of most chemical drugs targeting weight loss complicate their approval by regulatory authorities. Recently, interest has increased in the development of ingredients from natural sources with fewer adverse effects for preventing and ameliorating obesity. This review provides an overview of current anti-obesity drugs and natural products with anti-obesity properties as well as their mechanisms of action, which include interfering with nutrient absorption, decreasing adipogenesis, increasing energy expenditure (thermogenesis), appetite suppression, modifying intestinal microbiota composition, and increasing fecal fat excretion.
authors.affiliation: Guangdong TCM Key Laboratory for Metabolic Diseases, Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangdong Pharmaceutical University , Guangzhou Higher Education Mega Centre, Guangzhou 510006, China.
authors.forename: Chuhan
authors.identifier: http://orcid.org/0000-0003-4616-7618
authors.initials: C
authors.lastname: Fu
authors.affiliation: Guangdong TCM Key Laboratory for Metabolic Diseases, Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangdong Pharmaceutical University , Guangzhou Higher Education Mega Centre, Guangzhou 510006, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Guangdong TCM Key Laboratory for Metabolic Diseases, Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangdong Pharmaceutical University , Guangzhou Higher Education Mega Centre, Guangzhou 510006, China.
authors.forename: Jiao
authors.initials: J
authors.lastname: Guo
authors.affiliation: Guangdong TCM Key Laboratory for Metabolic Diseases, Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangdong Pharmaceutical University , Guangzhou Higher Education Mega Centre, Guangzhou 510006, China.
authors.forename: Zhengquan
authors.initials: Z
authors.lastname: Su
mesh_terms: D019440:Anti-Obesity Agents / Q000008:administration & dosage*; D001069:Appetite Regulation / Q000187:drug effects; D001688:Biological Products / Q000008:administration & dosage*; D004734:Energy Metabolism / Q000187:drug effects; D006801:Humans; D009765:Obesity / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D022722:Thermogenesis / Q000187:drug effects
chemical_list: D019440:Anti-Obesity Agents; D001688:Biological Products
keywords: chemical drug; mechanism; natural product; obesity; pharmacotherapy