title: Late Restenosis After Both First-Generation and Second-Generation Drug-Eluting Stent Implantations Occurs in Patients With Drug-Eluting Stent Restenosis.
abstract: There are currently inadequate data about whether late restenosis occurs after drug-eluting stent (DES) implantation in patients with DES restenosis.
  
  
  
  We collected data for 608 patients who received revascularization for DES restenosis between 2004 and 2012 and analyzed 688 lesions: 359 lesions treated with a first-generation DES (first DES) and 329 lesions treated with a second-generation DES (second DES). Two serial angiographic follow-ups were routinely planned for the patients (at 8 and 20 months after the procedure). Early follow-up angiography was performed for 620 lesions (90.1%), and recurrent restenosis occurred in 84 lesions (25.8%) in the first DES group and in 72 lesions (24.5%) in the second DES group (P=0.78). Target lesion revascularization was performed for 69 lesions (21.2%) in the first DES group and for 48 lesions (16.3%) in the second DES group (P=0.15). Late follow-up angiography was performed for 438 (87.1%) of the remaining 503 lesions (excluding target lesion revascularization lesions), and late restenosis was found in 35 lesions (15.8%) in the first DES group and in 28 lesions (14.7%) in the second DES group (P=0.79). Nonfocal-type restenosis, percentage diameter stenosis after the procedure, previous stent size ≤2.5 mm, and right coronary artery ostial lesion were independent predictors of early restenosis. Nonfocal-type restenosis, percentage diameter stenosis at early follow-up, and stent fracture were independent predictors of late restenosis.
  
  
  
  Late restenosis occurs after both first DES implantation and second DES implantation for DES restenosis.
authors.affiliation: From the Department of Cardiology, Kurashiki Central Hospital, Japan. sh10461@kchnet.or.jp.
authors.forename: Seiji
authors.initials: S
authors.lastname: Habara
authors.affiliation: From the Department of Cardiology, Kurashiki Central Hospital, Japan.
authors.forename: Kazushige
authors.initials: K
authors.lastname: Kadota
authors.affiliation: From the Department of Cardiology, Kurashiki Central Hospital, Japan.
authors.forename: Akimune
authors.initials: A
authors.lastname: Kuwayama
authors.affiliation: From the Department of Cardiology, Kurashiki Central Hospital, Japan.
authors.forename: Takenobu
authors.initials: T
authors.lastname: Shimada
authors.affiliation: From the Department of Cardiology, Kurashiki Central Hospital, Japan.
authors.forename: Masanobu
authors.initials: M
authors.lastname: Ohya
authors.affiliation: From the Department of Cardiology, Kurashiki Central Hospital, Japan.
authors.forename: Katsuya
authors.initials: K
authors.lastname: Miura
authors.affiliation: From the Department of Cardiology, Kurashiki Central Hospital, Japan.
authors.forename: Hidewo
authors.initials: H
authors.lastname: Amano
authors.affiliation: From the Department of Cardiology, Kurashiki Central Hospital, Japan.
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Kubo
authors.affiliation: From the Department of Cardiology, Kurashiki Central Hospital, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Hyodo
authors.affiliation: From the Department of Cardiology, Kurashiki Central Hospital, Japan.
authors.forename: Suguru
authors.initials: S
authors.lastname: Otsuru
authors.affiliation: From the Department of Cardiology, Kurashiki Central Hospital, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Tada
authors.affiliation: From the Department of Cardiology, Kurashiki Central Hospital, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tanaka
authors.affiliation: From the Department of Cardiology, Kurashiki Central Hospital, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Fuku
authors.affiliation: From the Department of Cardiology, Kurashiki Central Hospital, Japan.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Goto
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D023903:Coronary Restenosis / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D054855:Drug-Eluting Stents; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects* / Q000295:instrumentation*; D011474:Prosthesis Design; D012008:Recurrence; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome
keywords: drug-eluting stent; in-stent restenosis; paclitaxel