title: Radiobiology in Cardiovascular Imaging.
abstract: The introduction of ionizing radiation in medicine revolutionized the diagnosis and treatment of disease and dramatically improved and continues to improve the quality of health care. Cardiovascular imaging and medical imaging in general, however, are associated with a range of radiobiologic effects, including, in rare instances, moderate to severe skin damage resulting from cardiac fluoroscopy. For the dose range associated with diagnostic imaging (corresponding to effective doses on the order of 10 mSv [1 rem]), the possible effects are stochastic in nature and largely theoretical. The most notable of these effects, of course, is the possible increase in cancer risk. The current review addresses radiobiology relevant to cardiovascular imaging, with particular emphasis on radiation induction of cancer, including consideration of the linear nonthreshold dose-response model and of alternative models such as radiation hormesis.
authors.affiliation: Memorial Sloan Kettering Cancer Center, New York, New York. Electronic address: zanzonip@mskcc.org.
authors.forename: Pat
authors.initials: P
authors.lastname: Zanzonico
authors.affiliation: Memorial Sloan Kettering Cancer Center, New York, New York.
authors.forename: Lawrence
authors.initials: L
authors.lastname: Dauer
authors.affiliation: Memorial Sloan Kettering Cancer Center, New York, New York.
authors.forename: H William
authors.initials: HW
authors.lastname: Strauss
mesh_terms: D002318:Cardiovascular Diseases / Q000000981:diagnostic imaging* / Q000503:physiopathology; D002319:Cardiovascular System / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000528:radiation effects*; D003952:Diagnostic Imaging / Q000009:adverse effects* / Q000379:methods*; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D011237:Predictive Value of Tests; D011829:Radiation Dosage; D000069079:Radiation Exposure / Q000009:adverse effects* / Q000517:prevention & control; D011832:Radiation Injuries / Q000209:etiology* / Q000517:prevention & control; D018570:Risk Assessment; D012307:Risk Factors; D013269:Stochastic Processes
keywords: cancer risks; deterministic effects; hormesis; linear nonthreshold model; linear-quadratic model; radiation dosimetry; radiation effects; radiation genetic effects; radiobiology; reverse causation; stochastic effects