title: Nutrition and chronic inflammatory rheumatic disease.
abstract: Nutrition is a major environmental influence on human health. Epidemiological and interventional studies suggest a pathophysiological or therapeutic role, respectively, for nutrition in inflammatory rheumatic diseases (IRDs). Nevertheless, the associations between nutrition and IRDs are often weak and inconsistent, and the available clinical trials on nutrition are methodologically flawed. Experimental evidence is accumulating that micronutrients in the diet may influence intestinal and systemic immune responses via complex interactions involving the gut microbiota. Micronutrients may, therefore, contribute to the pathogenesis of inflammatory diseases. No interventions targeting these interactions for diagnostic, prophylactic, or therapeutic purposes have been developed to date. Moreover, the relevance to human disease of experimental results obtained in animals or in vitro is unclear. Novel high-throughput technologies (-omics) may prove useful for a systems biology approach to these results that takes the complexity of the interactions into account. Concomitant cohort studies combining clinical and laboratory data collected over time may provide new impetus to research into the connections between nutrition and IRDs.
authors.affiliation: Inserm UMR 1125, 1, rue de Chablis, 93017 Bobigny, France; Sorbonne Paris Cité, université Paris 13, 1, rue de Chablis, 93017 Bobigny, France; Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpitaux Universitaires Paris-Seine-Saint-Denis, Service de Rhumatologie, 125, rue de Stalingrad, 93017 Bobigny, France. Electronic address: luca.semerano@aphp.fr.
authors.forename: Luca
authors.initials: L
authors.lastname: Semerano
authors.affiliation: Sorbonne Paris Cité, Université Paris 13, Équipe de Recherche en Epidémiologie Nutritionnelle (EREN), Centre d'Épidémiologie et Statistiques, 1, rue de Chablis, 93017 Bobigny, France; Inserm U1153, Inra U1125, Cnam, 1, rue de Chablis, 93017 Bobigny, France; Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpitaux Universitaires Paris-Seine-Saint-Denis, Département de Santé Publique, 125, rue de Stalingrad, 93017 Bobigny, France.
authors.forename: Chantal
authors.initials: C
authors.lastname: Julia
authors.affiliation: Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpitaux Universitaires Paris-Seine-Saint-Denis, Service de Rhumatologie, 125, rue de Stalingrad, 93017 Bobigny, France.
authors.forename: Ouidade
authors.initials: O
authors.lastname: Aitisha
authors.affiliation: Inserm UMR 1125, 1, rue de Chablis, 93017 Bobigny, France; Sorbonne Paris Cité, université Paris 13, 1, rue de Chablis, 93017 Bobigny, France; Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpitaux Universitaires Paris-Seine-Saint-Denis, Service de Rhumatologie, 125, rue de Stalingrad, 93017 Bobigny, France.
authors.forename: Marie-Christophe
authors.initials: MC
authors.lastname: Boissier
mesh_terms: D001172:Arthritis, Rheumatoid / Q000276:immunology / Q000503:physiopathology; D002908:Chronic Disease; D004032:Diet; D005260:Female; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000503:physiopathology*; D008297:Male; D064307:Microbiota / Q000276:immunology*; D015596:Nutrition Assessment; D011379:Prognosis; D012216:Rheumatic Diseases / Q000276:immunology / Q000503:physiopathology*
keywords: Diet; Fatty acids; Gut; Inflammation; Nutrition; Rheumatoid arthritis