title: Modulation of brain PUFA content in different experimental models of mice.
abstract: The relative amounts of arachidonic acid (AA) and docosahexaenoic acid (DHA) govern the different functions of the brain. Their brain levels depend on structures considered, on fatty acid dietary supply and the age of animals. To have a better overview of the different models available in the literature we here compared the brain fatty acid composition in various mice models (C57BL/6J, CD1, Fat-1, SAMP8 mice) fed with different n-3 PUFA diets (deficient, balanced, enriched) in adults and aged animals. Our results demonstrated that brain AA and DHA content is 1) structure-dependent; 2) strain-specific; 3) differently affected by dietary approaches when compared to genetic model of PUFA modulation; 4) different in n-3 PUFA deficient aged C57BL6/J when compared to SAMP8 mouse model of aging. From these experiments, we highlight the difficulty to compare results obtained in different mouse models, different strains, different brain regions and different ages.
authors.affiliation: Nutrition et Neurobiologie Intégrée, INRA UMR 1286, 33076 Bordeaux Cedex, Franceb University of Bordeaux, Bordeaux, France; Université de Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France. Electronic address: corinne.joffre@bordeaux.inra.fr.
authors.forename: Corinne
authors.initials: C
authors.lastname: Joffre
authors.affiliation: UMR CSGA 1324 INRA - 6265 CNRS - Université de Bourgogne, Eye, Nutrition and Signalization Research Group, F-21000 Dijon, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Grégoire
authors.affiliation: Nutrition et Neurobiologie Intégrée, INRA UMR 1286, 33076 Bordeaux Cedex, Franceb University of Bordeaux, Bordeaux, France; Université de Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France.
authors.forename: Véronique
authors.initials: V
authors.lastname: De Smedt
authors.affiliation: UMR CSGA 1324 INRA - 6265 CNRS - Université de Bourgogne, Eye, Nutrition and Signalization Research Group, F-21000 Dijon, France.
authors.forename: Niyazi
authors.initials: N
authors.lastname: Acar
authors.affiliation: UMR CSGA 1324 INRA - 6265 CNRS - Université de Bourgogne, Eye, Nutrition and Signalization Research Group, F-21000 Dijon, France.
authors.forename: Lionel
authors.initials: L
authors.lastname: Bretillon
authors.affiliation: Nutrition et Neurobiologie Intégrée, INRA UMR 1286, 33076 Bordeaux Cedex, Franceb University of Bordeaux, Bordeaux, France; Université de Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France.
authors.forename: Agnès
authors.initials: A
authors.lastname: Nadjar
authors.affiliation: Nutrition et Neurobiologie Intégrée, INRA UMR 1286, 33076 Bordeaux Cedex, Franceb University of Bordeaux, Bordeaux, France; Université de Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Layé
mesh_terms: D000818:Animals; D016718:Arachidonic Acid / Q000737:chemistry*; D001923:Brain Chemistry; D001933:Brain Stem / Q000737:chemistry; D002531:Cerebellum / Q000737:chemistry; D002540:Cerebral Cortex / Q000737:chemistry; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage*; D004281:Docosahexaenoic Acids / Q000737:chemistry*; D005260:Female; D006624:Hippocampus / Q000737:chemistry; D007031:Hypothalamus / Q000737:chemistry; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008962:Models, Theoretical; D017397:Prefrontal Cortex / Q000737:chemistry
chemical_list: D004042:Dietary Fats, Unsaturated; D004281:Docosahexaenoic Acids; D016718:Arachidonic Acid
keywords: Aging; Arachidonic acid (AA); Brain regions; Docosahexaenoic acid (DHA); Fat-1 mice; N-3 PUFA; SAMP8 mice