title: Outbreak of enterovirus D68 of the new B3 lineage in Stockholm, Sweden, August to September 2016.
abstract: We report an enterovirus D68 (EV-D68) outbreak in Stockholm Sweden in 2016. Between 22 August and 25 September EV-D68 was detected in 74/495 respiratory samples analysed at the Karolinska University Hospital. During the peak week, 30/91 (33%) samples were EV-D68 positive. Viral protein (VP)P4/VP2 sequencing revealed that cases were caused by B3 lineage strains. Forty-four (59%) EV-D68-positive patients were children aged ≤ 5 years. Ten patients had severe respiratory or neurological symptoms and one died.
authors.affiliation: Department of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden.|Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Robert
authors.initials: R
authors.lastname: Dyrdak
authors.affiliation: Department of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden.|Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Malin
authors.initials: M
authors.lastname: Grabbe
authors.affiliation: Department of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden.|Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Berit
authors.initials: B
authors.lastname: Hammas
authors.affiliation: Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden.
authors.forename: Jonas
authors.initials: J
authors.lastname: Ekwall
authors.affiliation: Department of Infectious Diseases, Södersjukhuset, Stockholm, Sweden.
authors.forename: Karin E
authors.initials: KE
authors.lastname: Hansson
authors.affiliation: Pediatric Infectious Disease Unit, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden.|Department of Women's and Children's Health, Karolinska Institute, Stockholm Sweden.
authors.forename: Joachim
authors.initials: J
authors.lastname: Luthander
authors.affiliation: Unit of Infectious Diseases, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.|Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden.
authors.forename: Pontus
authors.initials: P
authors.lastname: Naucler
authors.affiliation: Department of Anesthesiology and Intensive Care, Akademiska University Hospital, Uppsala, Sweden.|Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
authors.forename: Henrik
authors.initials: H
authors.lastname: Reinius
authors.affiliation: Department of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden.|Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Maria
authors.initials: M
authors.lastname: Rotzén-Östlund
authors.affiliation: Department of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden.|Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Jan
authors.initials: J
authors.lastname: Albert
mesh_terms: D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks; D004770:Enterovirus / Q000145:classification / Q000302:isolation & purification*; D030016:Enterovirus D, Human / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification*; D004769:Enterovirus Infections / Q000453:epidemiology* / Q000821:virology*; D005260:Female; D014644:Genetic Variation; D006801:Humans; D007223:Infant; D008297:Male; D010802:Phylogeny; D012141:Respiratory Tract Infections / Q000453:epidemiology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D013548:Sweden / Q000453:epidemiology; D015678:Viral Structural Proteins / Q000235:genetics
chemical_list: D015678:Viral Structural Proteins
keywords: VP4/VP2 sequencing; acute flaccid myelitis; enterovirus D68; outbreak; respiratory infection