title: Evaluation of the Biocompatibility of Polypyrrole Implanted Subdurally in GAERS.
abstract: This blinded controlled prospective randomized study investigates the biocompatibility of polypyrrole (PPy) polymer that will be used for intracranial triggered release of anti-epileptic drugs (AEDs). Three by three millimeters PPy are implanted subdurally in six adult female genetic absence epilepsy rats from Strasbourg. Each rat has a polymer implanted on one side of the cortex and a sham craniotomy performed on the other side. After a period of seven weeks, rats are euthanized and parallel series of coronal sections are cut throughout the implant site. Four series of 15 sections are histological (hematoxylin and eosin) and immunohistochemically (neuron-specific nuclear protein, glial fibrillary acidic protein, and anti-CD68 antibody) stained and evaluated by three investigators. The results show that implanted PPy mats do not induce obvious inflammation, trauma, gliosis, and neuronal toxicity. Therefore the authors conclude the PPy used offer good histocompatibility with central nervous system cells and that PPy sheets can be used as intracranial, AED delivery implant.
authors.affiliation: Translational Research and Animal Clinical Trial Study (TRACTS) Group, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, 250 Princes Hwy, Werribee, Victoria, 3030, Australia.
authors.forename: Sebastien H
authors.initials: SH
authors.lastname: Bauquier
authors.affiliation: Department of Medicine, The University of Melbourne at St Vincent's Hospital, P.O. Box 2900, Fitzroy, Victoria, 3065, Australia.
authors.forename: Karen J
authors.initials: KJ
authors.lastname: McLean
authors.affiliation: Department of Medicine, The University of Melbourne at St Vincent's Hospital, P.O. Box 2900, Fitzroy, Victoria, 3065, Australia.
authors.forename: Jonathan L
authors.initials: JL
authors.lastname: Jiang
authors.affiliation: Department of Medicine, The University of Melbourne at St Vincent's Hospital, P.O. Box 2900, Fitzroy, Victoria, 3065, Australia.
authors.forename: Ray C
authors.initials: RC
authors.lastname: Boston
authors.affiliation: Department of Medicine, The University of Melbourne at St Vincent's Hospital, P.O. Box 2900, Fitzroy, Victoria, 3065, Australia.
authors.forename: Alan
authors.initials: A
authors.lastname: Lai
authors.affiliation: Intelligent Polymer Research Institute and ARC Centre of Excellence for Electromaterials Science, AIIM Facility, Innovation Campus, University of Wollongong, Wollongong, New South Wales, 2522, Australia.
authors.forename: Zhilian
authors.initials: Z
authors.lastname: Yue
authors.affiliation: Intelligent Polymer Research Institute and ARC Centre of Excellence for Electromaterials Science, AIIM Facility, Innovation Campus, University of Wollongong, Wollongong, New South Wales, 2522, Australia.
authors.forename: Simon E
authors.initials: SE
authors.lastname: Moulton
authors.affiliation: Department of Medicine, The University of Melbourne at St Vincent's Hospital, P.O. Box 2900, Fitzroy, Victoria, 3065, Australia.
authors.forename: Amy J
authors.initials: AJ
authors.lastname: Halliday
authors.affiliation: Intelligent Polymer Research Institute and ARC Centre of Excellence for Electromaterials Science, AIIM Facility, Innovation Campus, University of Wollongong, Wollongong, New South Wales, 2522, Australia.
authors.forename: Gordon
authors.initials: G
authors.lastname: Wallace
authors.affiliation: Department of Medicine, The University of Melbourne at St Vincent's Hospital, P.O. Box 2900, Fitzroy, Victoria, 3065, Australia.
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Cook
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage* / Q000494:pharmacology; D001672:Biocompatible Materials; D003399:Craniotomy; D004353:Drug Evaluation, Preclinical; D004343:Drug Implants; D004388:Dura Mater; D005260:Female; D008264:Macrophages / Q000187:drug effects; D009457:Neuroglia / Q000187:drug effects; D009474:Neurons / Q000187:drug effects; D011108:Polymers / Q000008:administration & dosage* / Q000494:pharmacology; D011758:Pyrroles / Q000008:administration & dosage* / Q000494:pharmacology; D051381:Rats
chemical_list: D000927:Anticonvulsants; D001672:Biocompatible Materials; D004343:Drug Implants; D011108:Polymers; D011758:Pyrroles; C067635:polypyrrole
keywords: biocompatibility; cerebral cortex implants; conductive polymers; toxicity