title: The Influence of GH Treatment on Glucose Homeostasis in Girls With Turner Syndrome: A 7-Year Study.
abstract: BACKGROUND
  Growth hormone (GH) influences glucose homeostasis mainly by negatively affecting insulin sensitivity.
  
  
  OBJECTIVE
  To longitudinally study insulin sensitivity [via homeostasis model assessment of insulin sensitivity (HOMA-S)], insulin secretion [insulinogenic index (IGI)], and capacity of β cells to adapt to changes in insulin sensitivity [oral disposition index (ODI)] in girls with Turner syndrome (TS) undergoing GH treatment.
  
  
  METHODS
  Longitudinal, retrospective, 7-year study conducted in a tertiary pediatric endocrine unit and university pediatric clinic.
  
  
  METHODS
  We studied 104 patients with TS (mean age ± standard deviation, 9.1 ± 3.4 years) for a median of 7.2 years.
  
  
  METHODS
  Every year, the children underwent an oral glucose tolerance test, which was used to calculate HOMA-S, IGI, and ODI.
  
  
  RESULTS
  HOMA-S, IGI, and ODI did not significantly change.
  
  
  CONCLUSIONS
  The results are reassuring, showing no negative influence of GH treatment on insulin sensitivity and on β-cell secretory capacity in girls with TS.
authors.affiliation: Department of Woman, Child and Urologic Diseases, S. Orsola-Malpighi Hospital, University of Bologna, 40138 Bologna, Italy; and.
authors.forename: Federico
authors.initials: F
authors.lastname: Baronio
authors.affiliation: Department of Woman, Child and Urologic Diseases, S. Orsola-Malpighi Hospital, University of Bologna, 40138 Bologna, Italy; and.
authors.forename: Laura
authors.initials: L
authors.lastname: Mazzanti
authors.affiliation: Department of Pediatrics and.
authors.forename: Ylenia
authors.initials: Y
authors.lastname: Girtler
authors.affiliation: Department of Woman, Child and Urologic Diseases, S. Orsola-Malpighi Hospital, University of Bologna, 40138 Bologna, Italy; and.
authors.forename: Federica
authors.initials: F
authors.lastname: Tamburrino
authors.affiliation: Department of Pediatrics and.
authors.forename: Fiorenzo
authors.initials: F
authors.lastname: Lupi
authors.affiliation: Department of Pediatrics and.
authors.forename: Silvia
authors.initials: S
authors.lastname: Longhi
authors.affiliation: Department of Biostatistics, Regional Hospital, Bolzano 39100, Bolzano, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Fanolla
authors.affiliation: Department of Pediatrics and.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Radetti
mesh_terms: D000293:Adolescent; D001786:Blood Glucose / Q000378:metabolism*; D002648:Child; D005260:Female; D005951:Glucose Tolerance Test; D013006:Growth Hormone / Q000627:therapeutic use*; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D050417:Insulin-Secreting Cells / Q000378:metabolism; D008137:Longitudinal Studies; D012189:Retrospective Studies; D014424:Turner Syndrome / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D007328:Insulin; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone