title: Prognostic assessment of stable coronary artery disease as determined by coronary computed tomography angiography: a Danish multicentre cohort study.
abstract: To examine the 3.5 year prognosis of stable coronary artery disease (CAD) as assessed by coronary computed tomography angiography (CCTA) in real-world clinical practice, overall and within subgroups of patients according to age, sex, and comorbidity.
  
  
  
  This cohort study included 16,949 patients (median age 57 years; 57% women) with new-onset symptoms suggestive of CAD, who underwent CCTA between January 2008 and December 2012. The endpoint was a composite of late coronary revascularization procedure >90 days after CCTA, myocardial infarction, and all-cause death. The Kaplan-Meier estimator was used to compute 91 day to 3.5 year risk according to the CAD severity. Comparisons between patients with and without CAD were based on Cox-regression adjusted for age, sex, comorbidity, cardiovascular risk factors, concomitant cardiac medications, and post-CCTA treatment within 90 days. The composite endpoint occurred in 486 patients. Risk of the composite endpoint was 1.5% for patients without CAD, 6.8% for obstructive CAD, and 15% for three-vessel/left main disease. Compared with patients without CAD, higher relative risk of the composite endpoint was observed for non-obstructive CAD [hazard ratio (HR): 1.28; 95% confidence interval (CI): 1.01-1.63], obstructive one-vessel CAD (HR: 1.83; 95% CI: 1.37-2.44), two-vessel CAD (HR: 2.97; 95% CI: 2.09-4.22), and three-vessel/left main CAD (HR: 4.41; 95% CI :2.90-6.69). The results were consistent in strata of age, sex, and comorbidity.
  
  
  
  Coronary artery disease determined by CCTA in real-world practice predicts the 3.5 year composite risk of late revascularization, myocardial infarction, and all-cause death across different groups of age, sex, or comorbidity burden.
authors.affiliation: Department of Cardiology, Lillebaelt Hospital-Vejle, Kabbeltoft 25, DK-7100 Vejle, Denmark.
authors.forename: Lene H
authors.initials: LH
authors.lastname: Nielsen
authors.affiliation: Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: Hans Erik
authors.initials: HE
authors.lastname: Bøtker
authors.affiliation: Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: Henrik T
authors.initials: HT
authors.lastname: Sørensen
authors.affiliation: Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: Morten
authors.initials: M
authors.lastname: Schmidt
authors.affiliation: Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: Lars
authors.initials: L
authors.lastname: Pedersen
authors.affiliation: Department of Cardiology, Hospital of South West Jutland, Esbjerg, Denmark.
authors.forename: Niels Peter
authors.initials: NP
authors.lastname: Sand
authors.affiliation: Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: Jesper M
authors.initials: JM
authors.lastname: Jensen
authors.affiliation: Department of Cardiology, Lillebaelt Hospital-Vejle, Kabbeltoft 25, DK-7100 Vejle, Denmark.
authors.forename: Flemming H
authors.initials: FH
authors.lastname: Steffensen
authors.affiliation: Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark.
authors.forename: Hans Henrik
authors.initials: HH
authors.lastname: Tilsted
authors.affiliation: Department of Cardiology, Regional Hospital Herning, Herning, Denmark.
authors.forename: Morten
authors.initials: M
authors.lastname: Bøttcher
authors.affiliation: Department of Cardiology, Odense University Hospital, Denmark.
authors.forename: Axel
authors.initials: A
authors.lastname: Diederichsen
authors.affiliation: Department of Cardiology, Svendborg Hospital, Denmark.
authors.forename: Jess
authors.initials: J
authors.lastname: Lambrechtsen
authors.affiliation: Department of Cardiology, Regional Hospital Silkeborg, Silkeborg, Denmark.
authors.forename: Lone D
authors.initials: LD
authors.lastname: Kristensen
authors.affiliation: Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: Kristian A
authors.initials: KA
authors.lastname: Øvrehus
authors.affiliation: Department of Cardiology, Odense University Hospital, Denmark.
authors.forename: Hans
authors.initials: H
authors.lastname: Mickley
authors.affiliation: Department of Cardiology, Lillebaelt Hospital-Vejle, Kabbeltoft 25, DK-7100 Vejle, Denmark.
authors.forename: Henrik
authors.initials: H
authors.lastname: Munkholm
authors.affiliation: Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: Ole
authors.initials: O
authors.lastname: Gøtzsche
authors.affiliation: Department of Cardiology, Hospital of South West Jutland, Esbjerg, Denmark.
authors.forename: Majed
authors.initials: M
authors.lastname: Husain
authors.affiliation: Department of Cardiology, Regional Hospital Herning, Herning, Denmark.
authors.forename: Lars L
authors.initials: LL
authors.lastname: Knudsen
authors.affiliation: Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: Bjarne L
authors.initials: BL
authors.lastname: Nørgaard
mesh_terms: D000328:Adult; D000368:Aged; D060050:Angina, Stable / Q000000981:diagnostic imaging / Q000401:mortality; D015331:Cohort Studies; D000072226:Computed Tomography Angiography / Q000401:mortality; D017023:Coronary Angiography / Q000401:mortality; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000401:mortality; D003718:Denmark / Q000453:epidemiology; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000401:mortality; D009204:Myocardial Revascularization / Q000401:mortality; D062645:Percutaneous Coronary Intervention / Q000401:mortality; D011379:Prognosis
keywords: Comorbidity; Coronary atherosclerosis; Coronary computed tomography angiography; Prognosis; Stable angina 