title: MHC Bias by T Cell Receptors: Genetic Evidence for MHC and TCR Coevolution.
abstract: Major histocompatibility complex (MHC) restriction is a fundamental tenet of T cell biology, but the underlying mechanisms have remained controversial. The extent to which T cell receptors (TCRs) are biased towards MHC proteins in particular has been widely discussed. In a recent paper, Sharon et al. report direct evidence for coevolution between TCR and MHC genes, helping to explain how MHC compatibility and bias can be encoded within TCRs.
authors.affiliation: Department of Chemistry and Biochemistry, and the Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, USA.
authors.forename: Brian M
authors.initials: BM
authors.lastname: Baker
authors.affiliation: Department of Microbiology and Immunology, Emory University, Atlanta, GA, USA. Electronic address: bevavol@emory.edu.
authors.forename: Brian D
authors.initials: BD
authors.lastname: Evavold
mesh_terms: D000818:Animals; D017951:Antigen Presentation; D019143:Evolution, Molecular; D008040:Genetic Linkage; D006649:Histocompatibility Antigens / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008213:Lymphocyte Activation; D008285:Major Histocompatibility Complex / Q000235:genetics*; D040641:Quantitative Trait Loci / Q000235:genetics*; D011948:Receptors, Antigen, T-Cell / Q000235:genetics* / Q000378:metabolism; D013329:Structure-Activity Relationship; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D006649:Histocompatibility Antigens; D011948:Receptors, Antigen, T-Cell