title: Physical exercise in myasthenia gravis is safe and improves neuromuscular parameters and physical performance-based measures: A pilot study.
abstract: Due to the shortage of exercise-related research in Myasthenia Gravis (MG), there are no consensus guidelines on physical exercise for MG patients.
  
  
  
  In this prospective pilot study, 10 MG patients with mild disease performed supervised aerobic and resistance training twice weekly for 12 weeks. The Myasthenia Gravis Composite (MGC) score, compound motor action potential (CMAP), repetitive nerve stimulation, muscle force, physical performance-based measures, serum levels of interleukin-6, muscle enzymes, and immuno-microRNAs miR-150-5p and miR-21-5p were assessed before and after the training period.
  
  
  
  Physical exercise was well tolerated, and the MGC score was unchanged. Muscle resistance weights and CMAP amplitudes increased for biceps brachii and rectus femoris muscles, and physical performance-based measures improved. Muscle enzymes remained normal, whereas disease-specific microRNAs miR-150-5p and miR-21-5p were reduced after the training period.
  
  
  
  We propose that general recommendations regarding physical exercise can be applied safely to well-regulated MG patients. Muscle Nerve 56: 207-214, 2017.
authors.affiliation: Department of Clinical Neurophysiology, Department of Neuroscience, Uppsala University, Box 593, BMC, SE-75124, Sweden.|Department of Neurology, Ryhov County Hospital, Jönköping, Sweden.
authors.forename: Elisabet
authors.initials: E
authors.lastname: Westerberg
authors.affiliation: Department of Clinical Neurophysiology, Department of Neuroscience, Uppsala University, Box 593, BMC, SE-75124, Sweden.
authors.forename: Carl Johan
authors.initials: CJ
authors.lastname: Molin
authors.affiliation: Department of Clinical Neurophysiology, Department of Neuroscience, Uppsala University, Box 593, BMC, SE-75124, Sweden.
authors.forename: Ida
authors.initials: I
authors.lastname: Lindblad
authors.affiliation: Department of Physiotherapy, Department of Neuroscience, Uppsala University, Sweden.|Department of Medical Sciences, Respiratory Medicine and Allergology, Uppsala University, Uppsala, Sweden.
authors.forename: Margareta
authors.initials: M
authors.lastname: Emtner
authors.affiliation: Department of Clinical Neurophysiology, Department of Neuroscience, Uppsala University, Box 593, BMC, SE-75124, Sweden.
authors.forename: Anna Rostedt
authors.initials: AR
authors.lastname: Punga
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001823:Body Composition / Q000502:physiology; D019054:Evoked Potentials, Motor / Q000502:physiology; D015444:Exercise / Q000502:physiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000378:metabolism; D008875:Middle Aged; D053581:Muscle Strength Dynamometer; D009157:Myasthenia Gravis / Q000503:physiopathology* / Q000534:rehabilitation*; D009431:Neural Conduction / Q000502:physiology; D009469:Neuromuscular Junction / Q000502:physiology* / Q000503:physiopathology; D010865:Pilot Projects; D011446:Prospective Studies; D055070:Resistance Training / Q000379:methods*; D016896:Treatment Outcome
chemical_list: C548886:MIRN151a microRNA, human; C524940:MIRN21 microRNA, human; D035683:MicroRNAs
keywords: CMAP; microRNA; myasthenia gravis; neuromuscular; physical exercise; resistance training