title: Recent advances in proteomic applications for schistosomiasis research: potential clinical impact.
abstract: Schistosomiasis is a neglected tropical disease affecting hundreds of millions of people worldwide. Recent advances in the field of proteomics and the development of new and highly sensitive mass spectrometers and quantitative techniques have provided new tools for advancing the molecular biology, cell biology, diagnosis and vaccine development for public health threats such as schistosomiasis. Areas covered: In this review we describe the latest advances in research that utilizes proteomics-based tools to address some of the key challenges to developing effective interventions against schistosomiasis. We also provide information about the potential of extracellular vesicles to advance the fight against this devastating disease. Expert commentary: Different proteins are already being tested as vaccines against schistosomiasis with promising results. The re-analysis of the Schistosoma spp. proteomes using new and more sensitive mass spectrometers as well as better separation approaches will help identify more vaccine targets in a rational and informed manner. In addition, the recent development of new proteome microarrays will facilitate characterisation of novel markers of infection as well as new vaccine and diagnostic candidate antigens.
authors.affiliation: a Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine , James Cook University , Cairns , QLD , Australia.
authors.forename: Javier
authors.initials: J
authors.lastname: Sotillo
authors.affiliation: a Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine , James Cook University , Cairns , QLD , Australia.
authors.forename: Denise
authors.initials: D
authors.lastname: Doolan
authors.affiliation: a Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine , James Cook University , Cairns , QLD , Australia.
authors.forename: Alex
authors.initials: A
authors.lastname: Loukas
mesh_terms: D000818:Animals; D005260:Female; D015801:Helminth Proteins / Q000276:immunology; D006790:Host-Parasite Interactions / Q000502:physiology*; D006801:Humans; D008297:Male; D040901:Proteomics / Q000379:methods*; D012547:Schistosoma / Q000276:immunology* / Q000378:metabolism / Q000472:pathogenicity*; D012552:Schistosomiasis / Q000175:diagnosis* / Q000517:prevention & control; D014612:Vaccines / Q000494:pharmacology
chemical_list: D015801:Helminth Proteins; D014612:Vaccines
keywords: Schistosomiasis; diagnostics; exosomes; immunomics; proteomics; schistosoma; schistosomula; secreted; tegument; vaccine