title: Comparison of cartilage with temporalis fascia tympanoplasty: A meta-analysis of comparative studies.
abstract: To systematically review the results of type 1 tympanoplasty with temporalis fascia (TF) versus cartilage in patients with chronic otitis media (COM) for graft integration and hearing improvement.
  
  
  
  The English language literature (until June 1, 2016) was searched, using Medline (via PubMed), Scopus, ProQuest, Ovid, Cochrane database, and Google Scholar.
  
  
  
  A comprehensive review of the literature was performed. Prospective and retrospective studies enrolling patients with COM were included. Relevance and validity of selected articles were evaluated. Heterogeneity was assessed using I2statistics. For dichotomous variables, absolute rate differences, and number needed to treat (NNT) were calculated. For continuous variables, standard mean differences were calculated.
  
  
  
  A total of 11 prospective and 26 retrospective studies involving 3,606 patients were included. In general, the overall graft integration rates of cartilage and fascia tympanoplasty were 92% and 82%, respectively (NNT = 11.1, P < 0.001). Although there was no significant difference in the air-bone gap (ABG) closure of < 10 dB between the two groups, the subanalysis of prospective studies showed that patients in the TF group had less mean postoperative ABG (P = 0.02). Subgroup analysis of palisade grafts compared with that of TF graft revealed a significant difference in the graft integration rate favoring cartilage tympanoplasty (P = 0.01).
  
  
  
  Cartilage grafting seemed to show a higher graft integration rate compared with TF grafting. Both cartilage and fascia tympanoplasty provided similar improvements in the hearing outcome postoperatively. Large prospective trials are necessary to collect high-quality data.
  
  
  
  NA. Laryngoscope, 127:2139-2148, 2017.
authors.affiliation: Nose and Sinus Research Center, Amiralmomenin Hospital, Guilan University of Medical Sciences, Rasht, Iran.
authors.forename: Mir Mohammad
authors.initials: MM
authors.lastname: Jalali
authors.affiliation: Otorhinolaryngology Research Center, Department of Otolaryngology, Amir-A'lam Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Masoud
authors.initials: M
authors.lastname: Motasaddi
authors.affiliation: Otorhinolaryngology Research Center, Department of Otolaryngology, Amir-A'lam Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Kouhi
authors.affiliation: Otorhinolaryngology Research Center, Department of Otolaryngology, Amir-A'lam Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Sasan
authors.initials: S
authors.lastname: Dabiri
authors.affiliation: Kavosh Behavioral, Cognitive and Addiction Research Center, Shafa Hospital, Guilan University of Medical Sciences, Rasht, Iran.
authors.forename: Robabeh
authors.initials: R
authors.lastname: Soleimani
mesh_terms: D000328:Adult; D002356:Cartilage / Q000637:transplantation*; D002648:Child; D002908:Chronic Disease; D005205:Fascia / Q000637:transplantation*; D005260:Female; D006309:Hearing; D006801:Humans; D008297:Male; D009225:Myringoplasty / Q000379:methods*; D010033:Otitis Media / Q000503:physiopathology / Q000601:surgery*; D011184:Postoperative Period; D011446:Prospective Studies; D012189:Retrospective Studies; D013703:Temporal Muscle; D016896:Treatment Outcome; D014433:Tympanoplasty / Q000379:methods*
keywords: Comparison; graft integration; hearing; meta-analysis; outcome; tympanoplasty