title: The Association ofDRD2with Insight Problem Solving.
abstract: Although the insight phenomenon has attracted great attention from psychologists, it is still largely unknown whether its variation in well-functioning human adults has a genetic basis. Several lines of evidence suggest that genes involved in dopamine (DA) transmission might be potential candidates. The present study explored for the first time the association of dopamine D2 receptor gene (DRD2) with insight problem solving. Fifteen single-nucleotide polymorphisms (SNPs) coveringDRD2were genotyped in 425 unrelated healthy Chinese undergraduates, and were further tested for association with insight problem solving. Both single SNP and haplotype analysis revealed several associations ofDRD2SNPs and haplotypes with insight problem solving. In conclusion, the present study provides the first evidence for the involvement ofDRD2in insight problem solving, future studies are necessary to validate these findings.
authors.affiliation: Department of Psychology, Shandong Normal University Jinan, China.
authors.forename: Shun
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Psychology, Shandong Normal University Jinan, China.
authors.forename: Jinghuan
authors.initials: J
authors.lastname: Zhang
keywords: DRD2; creativity; dopamine; insight; insight problem solving