title: A peptide-based synthetic transcription factor selectively down-regulates the proto-oncogene CFOS in tumour cells and inhibits proliferation.
abstract: Selectively regulating genes is an important goal in Chemical Biology. We report the development of a peptide-based synthetic transcription factor which binds the targeted DNA sequence with high affinity and single base-pair discrimination capability. When delivered inside a tumor cell, it regulated targeted genes selectively and inhibited cell proliferation.
authors.affiliation: Department of Biophysics, Bose Institute, P-1/12 CIT Scheme VII M, Kolkata 700054, India. sidroykolkata@gmail.com.
authors.forename: Madhumita
authors.initials: M
authors.lastname: Chakraborty
authors.affiliation: Department of Biophysics, Bose Institute, P-1/12 CIT Scheme VII M, Kolkata 700054, India. sidroykolkata@gmail.com.
authors.forename: Siddhartha
authors.initials: S
authors.lastname: Roy
mesh_terms: D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D015536:Down-Regulation / Q000187:drug effects*; D006801:Humans; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D010455:Peptides / Q000138:chemical synthesis* / Q000494:pharmacology*; D011487:Protein Conformation; D000090063:Proto-Oncogene Mas; D016760:Proto-Oncogene Proteins c-fos / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D026362:Serum Response Factor / Q000737:chemistry / Q000378:metabolism*; D050807:ets-Domain Protein Elk-1 / Q000737:chemistry / Q000378:metabolism*
chemical_list: C494112:ELK1 protein, human; C000715470:MAS1 protein, human; D010455:Peptides; D000090063:Proto-Oncogene Mas; D016760:Proto-Oncogene Proteins c-fos; C476858:SRF protein, human; D026362:Serum Response Factor; D050807:ets-Domain Protein Elk-1