title: Invasive cutaneous infection due to Scopulariopsis brevicaulis unsuccessfully treated with high-dose micafungin in a neutropenic patient.
abstract: Scopulariopsis brevicaulis onychomycosis with local cutaneous invasion was diagnosed in an acute leukemia patient and unsuccessfully treated with high-dose micafungin, based on antifungal susceptibility testing. This case should alert clinicians to the possible severe evolution of onychomycosis in neutropenic patients and suggests that surgery should be preferred in such a situation.
authors.affiliation: Département d'Hématologie, Gustave Roussy, Université Paris-Saclay, 114 Avenue Edouard Vaillant, 94805, Villejuif, France.
authors.forename: Daniela
authors.initials: D
authors.lastname: Gavril
authors.affiliation: Département de Biologie-Pathologie, Gustave Roussy, Université Paris-Saclay, 94805, Villejuif, France.
authors.forename: Paul-Louis
authors.initials: PL
authors.lastname: Woerther
authors.affiliation: Département de Biologie-Pathologie, Gustave Roussy, Université Paris-Saclay, 94805, Villejuif, France.
authors.forename: Aicha
authors.initials: A
authors.lastname: Ben Lakhdar
authors.affiliation: Département de Médecine Oncologique, Gustave Roussy, Université Paris-Saclay, 94805, Villejuif, France.
authors.forename: Linda
authors.initials: L
authors.lastname: Mahjoubi
authors.affiliation: Département de Médecine Oncologique, Gustave Roussy, Université Paris-Saclay, 94805, Villejuif, France.
authors.forename: Emilie
authors.initials: E
authors.lastname: Routier
authors.affiliation: Département de Biologie-Pathologie, Gustave Roussy, Université Paris-Saclay, 94805, Villejuif, France.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Chachaty
authors.affiliation: Département de Soins Aigus, Gustave Roussy, Université Paris-Saclay, 94805, Villejuif, France.
authors.forename: Bertrand
authors.initials: B
authors.lastname: Gachot
authors.affiliation: Département d'Hématologie, Gustave Roussy, Université Paris-Saclay, 114 Avenue Edouard Vaillant, 94805, Villejuif, France.|Faculty of Medicine, University Paris-Sud, Le Kremlin-Bicêtre, France.
authors.forename: Stephane
authors.initials: S
authors.lastname: De Botton
authors.affiliation: Département d'Hématologie, Gustave Roussy, Université Paris-Saclay, 114 Avenue Edouard Vaillant, 94805, Villejuif, France.
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Micol
authors.affiliation: Département d'Hématologie, Gustave Roussy, Université Paris-Saclay, 114 Avenue Edouard Vaillant, 94805, Villejuif, France. christophe.willekens@gustaveroussy.fr.|Faculty of Medicine, University Paris-Sud, Le Kremlin-Bicêtre, France. christophe.willekens@gustaveroussy.fr.
authors.forename: Christophe
authors.initials: C
authors.lastname: Willekens
mesh_terms: D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use; D003881:Dermatomycoses / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D054714:Echinocandins / Q000627:therapeutic use*; D005260:Female; D005533:Foot Dermatoses / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D016867:Immunocompromised Host; D055666:Lipopeptides / Q000627:therapeutic use*; D000077551:Micafungin; D009503:Neutropenia / Q000150:complications* / Q000276:immunology; D014009:Onychomycosis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology; D060645:Scopulariopsis / Q000502:physiology*; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D000077551:Micafungin
keywords: Febrile neutropenia; Immunocompromised; Invasive fungal infection; Micafungin; Onychomycosis; Scopulariopsis spp.