title: Bioactive phenyl ether derivatives from the marine-derived fungus Aspergillus carneus.
abstract: A new phenyl ether derivative, 3-hydroxy-5-(3-hydroxy-5-methylphenoxy)-4-methoxybenzoic acid (1), along with two known analogues, 3,4-dihydroxy-5-(3-hydroxy-5-methylphenoxy)benzoic acid (2) and 3-hydroxy-5-(3-hydroxy-5-methylphenoxy)benzoic acid (3), were isolated from the fungus Aspergillus carneus collected from South China Sea. The structure elucidation of 1 was determined based on extensive NMR and MS spectroscopic analyses. Compound 2 showed a strong antioxidant activity with an IC50value of 19.3 μM which was close to the positive control ascorbic acid (IC50= 15.3 μM).
authors.affiliation: a Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry Education, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmaceutical Sciences , Hebei University , Baoding , China.
authors.forename: Lan-Lan
authors.initials: LL
authors.lastname: Xu
authors.affiliation: b Shijiazhuang Yiling Pharmaceutical Co. Ltd , Shijiazhuang , China.
authors.forename: Can-Can
authors.initials: CC
authors.lastname: Zhang
authors.affiliation: a Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry Education, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmaceutical Sciences , Hebei University , Baoding , China.
authors.forename: Xin-Yue
authors.initials: XY
authors.lastname: Zhu
authors.affiliation: a Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry Education, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmaceutical Sciences , Hebei University , Baoding , China.
authors.forename: Fei
authors.initials: F
authors.lastname: Cao
authors.affiliation: a Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry Education, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmaceutical Sciences , Hebei University , Baoding , China.
authors.forename: Hua-Jie
authors.initials: HJ
authors.lastname: Zhu
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D059001:Aquatic Organisms; D001230:Aspergillus / Q000737:chemistry*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010647:Phenyl Ethers / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: C000625986:3-hydroxy-5-(3-hydroxy-5-methylphenoxy)-4-methoxybenzoic acid; D000900:Anti-Bacterial Agents; D000975:Antioxidants; D010647:Phenyl Ethers
keywords: Aspergillus carneus; antioxidant activity; phenyl ether derivative