title: Therapeutic role of nitric oxide as emerging molecule.
abstract: NO has many physiological roles; in inflammation, pain, rheumatoid arthritis, immune system, gastroprotection, as antioxidant and reported to be a free radical scavenger.Intensive research on the biological functions of NO and other reactive nitrogen oxide species demands exogenous sources of NO donors as research tools and pharmaceuticals. Since the mid-1980s, the development of new NO donors has offered several advantages over theprevious NO donors, such as spontaneous release of NO, donation of NO under controlled rates, and even the targeting of NO to certain tissues. Nitric oxide releasing derivatives of conventional NSAIDs have been synthesized not only to avoid gastrotoxicity, but also for making them fit for topical delivery, targeting them to brain and increase their analgesic and anti-inflammatory activity. "Hybrid nitrates" have vital role in different like NSAIDs, Anti-platelet, Antileukemic, Glaucoma, Antihypertensive, Antimalarial etc.
authors.affiliation: Department of Pharmaceutical Chemistry, Indo-Soviet Friendship (I.S.F.) College of Pharmacy, Ferozepur G.T. Road, Moga, Punjab 142001, India; School of Pharmacy & Emerging Sciences, Baddi University of Emerging Sciences & Technology, Baddi 173205, India. Electronic address: sahil.mehta187@gmail.com.
authors.forename: Sahil
authors.initials: S
authors.lastname: Kumar
authors.affiliation: Department of Pharmaceutical Chemistry, Shivalik College of Pharmacy, Nangal, Distt. Roopnagar, Punjab 140126, India. Electronic address: rksingh244@gmail.com.
authors.forename: Rajesh K
authors.initials: RK
authors.lastname: Singh
authors.affiliation: Department of Pharmaceutical Chemistry, Indo-Soviet Friendship (I.S.F.) College of Pharmacy, Ferozepur G.T. Road, Moga, Punjab 142001, India; School of Pharmacy & Emerging Sciences, Baddi University of Emerging Sciences & Technology, Baddi 173205, India.
authors.forename: T R
authors.initials: TR
authors.lastname: Bhardwaj
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use*; D000962:Antimalarials / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use*; D006801:Humans; D015394:Molecular Structure; D009569:Nitric Oxide / Q000378:metabolism*; D020030:Nitric Oxide Donors / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use*; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use*; D013329:Structure-Activity Relationship
chemical_list: D000890:Anti-Infective Agents; D000959:Antihypertensive Agents; D000962:Antimalarials; D000970:Antineoplastic Agents; D020030:Nitric Oxide Donors; D010975:Platelet Aggregation Inhibitors; D009569:Nitric Oxide
keywords: Antihypertensive; Antimalarial; NO-donors; Nitric Oxide(NO); Non steroidal anti-inflammatory Drugs(NSAIDs)