title: Control of HIV-1 gene expression by SR proteins.
abstract: Cellular proteins are required for all steps of human immunodeficiency virus type 1 (HIV-1) gene expression including transcription, splicing, 3'-end formation/polyadenylation, nuclear export and translation. SR proteins are a family of cellular RNA-binding proteins that regulate and functionally integrate multiple steps of gene expression. Specific SR proteins are best characterised for regulating HIV-1 RNA splicing by binding specific locations in the viral RNA, though recently they have also been shown to control transcription, 3'-end formation, and translation. Due to their importance in regulating HIV-1 gene expression, SR proteins and their regulatory factors are potential antiviral drug targets.
authors.affiliation: Department of Infectious Diseases, King's College London, London SE1 9RT, U.K.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Mahiet
authors.affiliation: Department of Infectious Diseases, King's College London, London SE1 9RT, U.K.
authors.forename: Chad M
authors.initials: CM
authors.lastname: Swanson
mesh_terms: D020413:3' Untranslated Regions / Q000235:genetics; D015967:Gene Expression Regulation, Viral; D015497:HIV-1 / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008957:Models, Genetic; D011485:Protein Binding; D012326:RNA Splicing; D012367:RNA, Viral / Q000235:genetics* / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D014771:Virion / Q000235:genetics / Q000378:metabolism
chemical_list: D020413:3' Untranslated Regions; D012367:RNA, Viral; D016601:RNA-Binding Proteins
keywords: HIV; RNA metabolism; SR proteins; alternative splicing; eukaryotic gene expression