title: Tachykinin Receptor 3 Distribution in Human Oral Squamous Cell Carcinoma.
abstract: Tachykinin 3 (TAC3) and its preferred tachykinin receptor 3 (TACR3) that are prominently detected in the central nervous system, play significant roles in physiological development and specifically in the human reproductive system. The roles of TAC3/TACR3 in oral squamous cell carcinoma are unknown.
  
  
  
  We examined the expression pattern of TAC3/TACR3 in clinically-resected oral squamous cell carcinoma samples using immunohistochemistry and immunofluorescence analysis.
  
  
  
  We found that even though the expression level of TACR3 was negative in the normal epithelium, it was highly elevated in tumor cells. A more intense signal was observed in the invasive front of tumor cells that had migrated into the mandible bone matrix. TAC3 was not detected in tumor cells, but was expressed in PGP-9.5-positive sensory nerves in the mandible.
  
  
  
  Our results suggest that peripheral sensory nerve-derived TAC3 may affect gingival oral squamous cell carcinoma cells through TACR3 in the bone matrix.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Okayama, Japan.
authors.forename: Kyoichi
authors.initials: K
authors.lastname: Obata
authors.affiliation: Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Okayama, Japan shimotsu@md.okayama-u.ac.jp.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Shimo
authors.affiliation: Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Okayama, Japan.
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Okui
authors.affiliation: Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Okayama, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Matsumoto
authors.affiliation: Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Okayama, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Takada
authors.affiliation: Department of Oral Pathology and Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Kiyofumi
authors.initials: K
authors.lastname: Takabatake
authors.affiliation: Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Okayama, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kunisada
authors.affiliation: Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Okayama, Japan.
authors.forename: Soichiro
authors.initials: S
authors.lastname: Ibaragi
authors.affiliation: Department of Oral Pathology and Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Nagatsuka
authors.affiliation: Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Okayama, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Sasaki
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D006801:Humans; D009062:Mouth Neoplasms / Q000378:metabolism*; D018042:Receptors, Neurokinin-3 / Q000378:metabolism*; D018039:Receptors, Tachykinin / Q000378:metabolism*
chemical_list: D018042:Receptors, Neurokinin-3; D018039:Receptors, Tachykinin; C000601381:TACR3 protein, human
keywords: Tachykinin receptor 3; oral squamous cell carcinoma; tachykinin 3