title: Immune by Heart: Unexpected Observations Inspiring Perspective Therapeutic/Preventive Strategies against Cancer.
abstract: We often overlook ordinary events that take place right in front of our eyes. However, such events might be inspiring sources of revolutionary scientific discovery. Simple observations, such as those regarding the substantial immunity of the heart to cancer or the noninvasive behavior of plant tumors, are just the tips of icebergs hiding profound mechanistic causes that deserve deeper investigation. Several current or unprecedented approaches aimed at improving both the prevention and treatment of tumors are discussed on these bases herein. This viewpoint is not intended to give definitive answers, but rather to provide cues for discussion and motivation to pursue unexplored and accessible strategies to fight cancer.
authors.affiliation: Dipartimento di Farmacia, Università di Pisa, Via Bonanno 33, 56126, Pisa, Italy.
authors.forename: Filippo
authors.identifier: http://orcid.org/0000-0002-3312-104X
authors.initials: F
authors.lastname: Minutolo
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D006801:Humans; D007167:Immunotherapy; D008264:Macrophages / Q000276:immunology; D009369:Neoplasms / Q000188:drug therapy* / Q000276:immunology* / Q000517:prevention & control; D009504:Neutrophils / Q000276:immunology; D057285:Precision Medicine
chemical_list: D000970:Antineoplastic Agents
keywords: cancer; heart; immune cells; metabolism; plants