title: NOVEL FINDINGS ON OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN PATIENTS WITH TUBERCULAR SERPIGINOUS-LIKE CHOROIDITIS.
abstract: OBJECTIVE
  To analyze and describe the imaging characteristics of tubercular serpiginous-like choroiditis using optical coherence tomography angiography (OCTA) and to compare these findings with multimodal imaging.
  
  
  METHODS
  In this prospective cross-sectional study, multimodal imaging was performed in subjects with tubercular serpiginous-like choroiditis using OCTA (Optovue RTVue XR Avanti), enhanced-depth imaging OCT (Heidelberg Spectralis), fundus autofluorescence, fluorescein angiography, and indocyanine green angiography. Distinct morphologic features of the retinochoroidal vasculature at the sites of choroiditis lesions were analyzed on OCTA imaging. Multimodal imaging analysis was performed to study the changes observed on OCTA.
  
  
  RESULTS
  Eighteen eyes (18 subjects, 16 males) were included in the study. The en face OCTA images demonstrated discrete areas of flow void beneath the retinal pigment epithelium-Bruch membrane layer suggestive of choriocapillaris hypoperfusion that corresponded well with indocyanine green angiography, especially in the chronic phase. Additional information such as areas of preserved choriocapillaris, vascular tufts, and tangled vessels were observed using OCTA among lesions in advanced stages of healing. Compared with indocyanine green angiography, the areas of choriocapillaris atrophy appeared better defined on OCTA and correlated well with enhanced-depth imaging OCT.
  
  
  CONCLUSIONS
  The OCTA images provide high-resolution structural information of the retinochoroidal vasculature in tubercular serpiginous-like choroiditis. Morphologic information obtained from OCTA images correlates well with and supplements other imaging techniques such as indocyanine green angiography and enhanced-depth imaging OCT.
authors.affiliation: *Advanced Eye Center, Postgraduate Institute of Medical Education and Research, Chandigarh, India; †Stanley M. Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, Nebraska; and ‡Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: Spoorti Krishna Reddy
authors.initials: SKR
authors.lastname: Mandadi
authors.forename: Aniruddha
authors.initials: A
authors.lastname: Agarwal
authors.forename: Kanika
authors.initials: K
authors.lastname: Aggarwal
authors.forename: Bruttendu
authors.initials: B
authors.lastname: Moharana
authors.forename: Ramandeep
authors.initials: R
authors.lastname: Singh
authors.forename: Aman
authors.initials: A
authors.lastname: Sharma
authors.forename: Reema
authors.initials: R
authors.lastname: Bansal
authors.forename: Mangat R
authors.initials: MR
authors.lastname: Dogra
authors.forename: Vishali
authors.initials: V
authors.lastname: Gupta
mesh_terms: D000293:Adolescent; D000328:Adult; D002833:Choroiditis / Q000000981:diagnostic imaging*; D003430:Cross-Sectional Studies; D005260:Female; D005451:Fluorescein Angiography / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D011446:Prospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods*; D014392:Tuberculosis, Ocular / Q000150:complications / Q000000981:diagnostic imaging*; D055815:Young Adult