title: Prevalence of asthma among school children in Gaborone, Botswana.
abstract: BACKGROUND
  Asthma prevalence is high (>10%) in developed countries and although data is still missing for most of Africa, rates are increasing in developing regions as they become more westernized. We investigated the prevalence of asthma in school children in Gaborone, Botswana.
  
  
  METHODS
  This was a cross sectional descriptive study. ISAAC methodology was used. A representative proportionate size random sample of two age groups of children (13-14 year olds and 6-7 year olds) was consecutively enrolled from 10 schools. The schools were selected using a table of random numbers. A minimum sample size of 924 individuals (462 from each group) was adequate to achieve a precision of 3 % around our estimated prevalence of asthma of 10% with 95% confidence assuming a non-response rate of 20%. Data was collected using the validated International study of Asthma and Allergies in children (ISAAC) questionnaire. In accordance with the ISAAC criteria, Asthma was defined as wheezing in the previous 12 months. Data was captured in microsoft excel and analysed using SPSS version 23.
  
  
  RESULTS
  The prevalence of asthma (wheezing in the previous 12 months) was 16.5% (194/1175). Among the 6-7 year olds, the prevalence of asthma (wheezing in the previous 12 months) was 15.9%, while among the 13-14 years olds it was 16.8 %. The prevalence school type was 22.3 % in private schools versus 14.5 % in public schools. More severe asthma was associated with older children, 13-14 years. The older children reported more limited speech due to wheezing (OR= 2.0, 95% CI =1.034, 3.9, p-value=0.043), ever had asthma (OR= 1.5, 95% CI=1.031, 2.3, p-value=0.034) and wheezing during exercise (OR=3.4, 95% CI= 2.5, 4.9, p-value= <0.001) compared to the younger children 6-7 years. Children from private schools had more wheezing symptoms. They were more likely to have ever wheezed (OR=2.2, .95% CI=1.7,2.9, p-value < 0.0001), wheezed in the previous twelve months (have asthma) (OR=1.7,95%CI=1.2,2.4, p-value = 0.001), ever had asthma (OR=2.4, 95% CI=1.7,3.5, p-value< 0.0001), and wheezed during exercise (OR=1.8, 95% CI=1.4,2.4, p-value < 0.0001).
  
  
  CONCLUSIONS
  The prevalence of asthma amongst school children in Gaborone, Botswana is high with older children experiencing more severe symptoms of asthma.
authors.affiliation: Department of Paediatrics & Adolescent Health, Faculty of Medicine, University of Botswana, Gaborone, Botswana.
authors.forename: Andrew
authors.initials: A
authors.lastname: Kiboneka
authors.affiliation: Allergy Division, Department of Paediatrics & Child Health, University of Cape Town and Red Cross Memorial Children's Hospital, South Africa.
authors.forename: Michael
authors.initials: M
authors.lastname: Levin
authors.affiliation: Department of Paediatrics & Adolescent Health, Faculty of Medicine, University of Botswana, Gaborone, Botswana.
authors.forename: Thembisile
authors.initials: T
authors.lastname: Mosalakatane
authors.affiliation: Department of Paediatrics & Adolescent Health, Princess Marina Hospital, Gaborone,Botswana.
authors.forename: Ishmael
authors.initials: I
authors.lastname: Makone
authors.affiliation: Directorate of Paediatrics & Child Health, Mulago National Referral Hospital, Kampala, Uganda.
authors.forename: Eric
authors.initials: E
authors.lastname: Wobudeya
authors.affiliation: Department of Mathematics & Computational Sciences, Botswana International University of Science & Technology Palapye, Botswana.
authors.forename: Boikanyo
authors.initials: B
authors.lastname: Makubate
authors.affiliation: Division of Allergy/Immunology, Creighton University Medical Centre, Omaha, Nebraska, USA.
authors.forename: Russell
authors.initials: R
authors.lastname: Hopp
authors.affiliation: Department of Paediatrics & Adolescent Health, Faculty of Medicine, University of Botswana, Gaborone, Botswana.
authors.forename: Loeto
authors.initials: L
authors.lastname: Mazhani
authors.affiliation: Division of Allergy & Immunology, Children's Hospital of Philadelphia, Pennsylvania, USA.
authors.forename: Shiang-Ju
authors.initials: SJ
authors.lastname: Kung
mesh_terms: D000293:Adolescent; D001249:Asthma / Q000453:epidemiology* / Q000503:physiopathology; D001902:Botswana / Q000453:epidemiology; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006306:Health Surveys; D006801:Humans; D008297:Male; D015995:Prevalence; D012574:Schools
keywords: Children; asthma; prevalence; school