title: [Hand osteoarthritis].
abstract: Hand osteoarthritis (OA) is a common chronic disorder causing pain and limitation of mobility of affected joints. The prevalence of hand OA increases with age and more often affects females. Clinical signs obviously do not correlate with radiographic findings - symptomatic hand OA affects approximately 26 % of adult subjects, but radiographic changes can be found in up to two thirds of females and half of males older than 55 years.Disease course differ among individual patients. Hand OA is a heterogeneous disease. Nodal hand OA is the most common subtype affecting interphalangeal joints, thumb base OA affects first carpometacarpal joint. Erosive OA represents a specific subtype of hand OA, which is associated with joint inflammation, more pain, functional limitation and erosive findings on radiographs.Treatment of OA is limited. Analgesics and nonsteroidal anti-inflammatory drugs are the only agents reducing symptoms. New insights into the pathogenesis of disease should contribute to the development of novel effective treatment of hand OA.
authors.forename: Ladislav
authors.initials: L
authors.lastname: Šenolt
mesh_terms: D000328:Adult; D000368:Aged; D052737:Carpometacarpal Joints / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D050823:Hand Joints / Q000000981:diagnostic imaging / Q000473:pathology*; D018737:Hand Strength; D006801:Humans; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000473:pathology*; D015995:Prevalence; D011859:Radiography; D018570:Risk Assessment; D016896:Treatment Outcome
keywords: hand osteoarthritis; thumb base osteoarthritis erosive changes.