title: Risk Factors for Endometrial Cancer: Results from a Hospital-Based Case-Control Study
abstract: Objectives: The purpose of this investigation was to examine the association between endometrial cancer and possible
  etiological agents. Methods: A case-control study was conducted in Iran between March 2012 and May 2016. The
  demographic and reproductive factors of 205 women with endometrial cancer were compared, and 590 healthy cases
  were participated in the control group. For each endometrial cancer case, there were three controls, who were matched
  in terms of age and residence. The data were considered significant at p ≤0.05. Results: After adjusting the variables,
  the nulliparity (OR 6.23, 95% CI 2.86-13.59), the nulligravidity (OR 5.94, 95% CI 2.51-14.06), the positive family
  history of reproductive cancer (OR 4.97, 95% CI 2.33-10.59), the infertility history (OR 2.38, 95%CI 1.32-4.31), the
  obesity (BMI ≥25) (OR 1.71, 95% CI 1.16-2.52), the early menarche age (<12 years) (OR 2.10, 95% CI 1.17-3.75),
  and the hormonal contraception use (OR 1.69, 95% CI 1.15-2.49) were found to be associated with an increased risk of
  endometrial cancer. Nevertheless, the education level, the job of women, the marital age, the leisure activities, and the
  breast feeding were not found to be associated with the endometrial cancer after adjusting the variables. Conclusion:
  Scheduling of the screening program is vitally indispensable to identify endometrial cancer in women with nulliparity,
  nulligravidity and the positive family history of cancer. In addition, women with early menarche, those with the history
  of infertility, the obese ones, and those who use contraception pills need to be particularly aware of the potential risks.
authors.affiliation: Infertility and Reproductive Health Research Center, Health Research Institute, Babol University of Medical Science, Babol, Iran. Email:sesmael@yahoo.com
authors.forename: Maryam
authors.initials: M
authors.lastname: Ghanbari Andarieh
authors.forename: Mouloud
authors.initials: M
authors.lastname: Agajani Delavar
authors.forename: Dariush
authors.initials: D
authors.lastname: Moslemi
authors.forename: Sedighe
authors.initials: S
authors.lastname: Esmaeilzadeh
keywords: Endometrial cancer; risk factors; case-control; parity; gravidity; positive family history