title: Darwin Comes to Clinic.
abstract: What might be the benefits of whole-genome rather than whole-exome sequencing (WES) for identifying the genetic causes of human disabilities? A recent paper by Doan et al. focuses attention on mutations in human accelerated regions (HARs), a subset of genomic regulatory elements showing accelerated evolution between chimpanzees and humans.
authors.affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: abeaudet@bcm.edu.
authors.forename: Arthur L
authors.initials: AL
authors.lastname: Beaudet
mesh_terms: D000818:Animals; D019143:Evolution, Molecular; D059472:Exome / Q000235:genetics; D030342:Genetic Diseases, Inborn; D015894:Genome, Human / Q000235:genetics*; D023281:Genomics; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D009154:Mutation; D002679:Pan troglodytes / Q000235:genetics; D012045:Regulatory Sequences, Nucleic Acid / Q000235:genetics*