title: A study on biological activity of marine fungi from different habitats in coastal regions.
abstract: In recent years, marine fungi have become an important source of active marine natural products. Former researches are limited in habitats selection of fungi with bioactive compounds. In this paper were to measure antibacterial and antitumor cell activity for secondary metabolites of marine fungi, which were isolated from different habitats in coastal regions. 195 strains of marine fungi were isolated and purified from three different habitats. They biologically active experiment results showed that fungi isolation from the mangrove habitats had stronger antibacterial activity than others, and the stains isolated from the estuarial habitats had the least antibacterial activity. However, the strains separated from beach habitats strongly inhibited tumor cell proliferation in vitro, and fungi of mangrove forest habitats had the weakest activity of inhibiting tumor. Meanwhile, 195 fungal strains belonged to 46 families, 84 genera, 142 species and also showed 137 different types of activity combinations by analyzing the inhibitory activity of the metabolites fungi for 4 strains of pathogenic bacteria and B-16 cells. The study investigated the biological activity of marine fungi isolated from different habitats in Haikou coastal regions. The results help us to understand bioactive metabolites of marine fungi from different habitats, and how to selected biological activity fungi from various marine habitats effectively.
authors.affiliation: Key Laboratory of Tropical Diseases and Translational Medicine of The Ministry of Education, Hainan Medical College, Haikou, 571199 China.
authors.forename: Songlin
authors.initials: S
authors.lastname: Zhou
authors.affiliation: Key Laboratory of Tropical Diseases and Translational Medicine of The Ministry of Education, Hainan Medical College, Haikou, 571199 China.
authors.forename: Min
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Aquatic Science and Technology, Jiangsu Agri-animal Husbandry Vocational College, Taizhou, 225300 China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Feng
authors.affiliation: Key Laboratory of Tropical Diseases and Translational Medicine of The Ministry of Education, Hainan Medical College, Haikou, 571199 China.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Lin
authors.affiliation: Key Laboratory of Tropical Diseases and Translational Medicine of The Ministry of Education, Hainan Medical College, Haikou, 571199 China.
authors.forename: Huange
authors.initials: H
authors.lastname: Zhao
keywords: Biological activity; Diversity; Habitats; Marine fungus