title: Familial clustering of nasopharyngeal carcinoma in non-endemic area. Report of three families.
abstract: Nasopharyngeal carcinoma is the predominant tumour type arising in the nasopharynx. Its aetiology is multifactorial; racial and geographical distribution, EBV infection and environmental exposure to specific substances are considered risk factors. This condition is endemic in some Asian areas, where a genetic predisposition in its oncogenesis has been established. There is a strong susceptibility between nasopharyngeal carcinoma and HLA, where related specific haplotypes have been found. In areas where the incidence is low, there are few reported cases of families affected. We report 3 cases of families with nasopharyngeal carcinoma among siblings, in the non-Asian population, probably related to EBV infection.
authors.affiliation: Servicio de Oncología Médica, Hospital Universitario de Salamanca, Salamanca, España. Electronic address: Pedshy16@hotmail.com.
authors.forename: Leydy Mallerling
authors.initials: LM
authors.lastname: Paredes-Durán
authors.affiliation: Servicio de Oncología Médica, Hospital Universitario de Salamanca, Salamanca, España.
authors.forename: Elvira
authors.initials: E
authors.lastname: Del Barco-Morillo
authors.affiliation: Servicio de Oncología Médica, Hospital Universitario de Salamanca, Salamanca, España.
authors.forename: María Jesús
authors.initials: MJ
authors.lastname: Baldeón-Conde
authors.affiliation: Servicio de Oncología Médica, Hospital Universitario de Salamanca, Salamanca, España.
authors.forename: Soledad
authors.initials: S
authors.lastname: Medina-Valdivieso
authors.affiliation: Servicio de Oncología Médica, Hospital Universitario de Salamanca, Salamanca, España.
authors.forename: María Cecilia
authors.initials: MC
authors.lastname: Guillen-Sacoto
authors.affiliation: Servicio de Oncología Médica, Hospital Universitario de Salamanca, Salamanca, España.
authors.forename: Juan Jesús
authors.initials: JJ
authors.lastname: Cruz-Hernández
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002277:Carcinoma / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000235:genetics* / Q000628:therapy; D002945:Cisplatin / Q000008:administration & dosage; D020031:Epstein-Barr Virus Infections / Q000453:epidemiology; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000235:genetics* / Q000628:therapy; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D013030:Spain / Q000453:epidemiology
chemical_list: D002945:Cisplatin; D005472:Fluorouracil
keywords: Aetiology; Agregación familiar; Carcinoma nasofaríngeo; Etiología; Familial aggregation; Low-incidence area; Nasopharyngeal carcinoma; Área de baja incidencia