title: Integration of B-cell receptor-induced ERK1/2 phosphorylation and mutations ofSF3B1gene refines prognosis in treatment-naïve chronic lymphocytic leukemia.
authors.affiliation: Research Center LURM, University of Verona, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Cavallini
authors.affiliation: Department of Cell Therapy and Hematology, San Bortolo Hospital, Vicenza, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Visco
authors.affiliation: Qognit Inc., Foster City, CA, USA.
authors.forename: Santosh
authors.initials: S
authors.lastname: Putta
authors.affiliation: Hematology, Oncology Institute of Southern Switzerland and Institute of Oncology Research, Bellinzona, Switzerland.
authors.forename: Davide
authors.initials: D
authors.lastname: Rossi
authors.affiliation: Department of Medicine, Section of Hematology, University of Verona, Italy.
authors.forename: Elda
authors.initials: E
authors.lastname: Mimiola
authors.affiliation: Pierian Biosciences, Franklin, TN, USA.
authors.forename: Norman
authors.initials: N
authors.lastname: Purvis
authors.affiliation: Research Center LURM, University of Verona, Italy.
authors.forename: Ornella
authors.initials: O
authors.lastname: Lovato
authors.affiliation: Department of Cell Therapy and Hematology, San Bortolo Hospital, Vicenza, Italy.
authors.forename: Omar
authors.initials: O
authors.lastname: Perbellini
authors.affiliation: Department of Cell Therapy and Hematology, San Bortolo Hospital, Vicenza, Italy.
authors.forename: Erika
authors.initials: E
authors.lastname: Falisi
authors.affiliation: Department of Medicine, Hematology and Clinical Immunology Branch, University of Padua, Italy.
authors.forename: Monica
authors.initials: M
authors.lastname: Facco
authors.affiliation: Department of Medicine, Hematology and Clinical Immunology Branch, University of Padua, Italy.
authors.forename: Livio
authors.initials: L
authors.lastname: Trentin
authors.affiliation: Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biology and Genetics, University of Verona, Italy.
authors.forename: Maria G
authors.initials: MG
authors.lastname: Romanelli
authors.affiliation: Department of Medicine, Hematology and Clinical Immunology Branch, University of Padua, Italy.
authors.forename: Gianpietro
authors.initials: G
authors.lastname: Semenzato
authors.affiliation: Department of Medicine, Section of Hematology, University of Verona, Italy.
authors.forename: Achille
authors.initials: A
authors.lastname: Ambrosetti
authors.affiliation: Department of Translational Medicine, Division of Hematology, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy.
authors.forename: Gianluca
authors.initials: G
authors.lastname: Gaidano
authors.affiliation: Department of Medicine, Section of Hematology, University of Verona, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Pizzolo
authors.affiliation: NanoString, Inc, Seattle, WA, USA.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Cesano
authors.affiliation: Research Center LURM, University of Verona, Italy mariateresa.scupoli@univr.it.|Department of Medicine, Section of Hematology, University of Verona, Italy.
authors.forename: Maria T
authors.initials: MT
authors.lastname: Scupoli
mesh_terms: D051997:ADP-ribosyl Cyclase 1 / Q000235:genetics / Q000276:immunology; D018450:Disease Progression; D015973:Gene Expression Regulation, Leukemic; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics / Q000378:metabolism; D007135:Immunoglobulin Variable Region / Q000235:genetics / Q000378:metabolism; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis* / Q000235:genetics / Q000401:mortality / Q000473:pathology; D008562:Membrane Glycoproteins / Q000235:genetics / Q000276:immunology; D019950:Mitogen-Activated Protein Kinase 1 / Q000235:genetics* / Q000276:immunology; D048052:Mitogen-Activated Protein Kinase 3 / Q000235:genetics* / Q000276:immunology; D009154:Mutation; D010750:Phosphoproteins / Q000235:genetics* / Q000276:immunology; D010766:Phosphorylation; D011379:Prognosis; D000072260:RNA Splicing Factors / Q000235:genetics* / Q000276:immunology; D051881:Receptor, Notch1 / Q000235:genetics / Q000276:immunology; D011947:Receptors, Antigen, B-Cell / Q000235:genetics* / Q000276:immunology; D015398:Signal Transduction; D016019:Survival Analysis; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000276:immunology
chemical_list: D007143:Immunoglobulin Heavy Chains; D007135:Immunoglobulin Variable Region; D008562:Membrane Glycoproteins; C497761:NOTCH1 protein, human; D010750:Phosphoproteins; D000072260:RNA Splicing Factors; D051881:Receptor, Notch1; D011947:Receptors, Antigen, B-Cell; C112491:SF3B1 protein, human; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; C535150:MAPK1 protein, human; D019950:Mitogen-Activated Protein Kinase 1; D048052:Mitogen-Activated Protein Kinase 3; C498154:CD38 protein, human; D051997:ADP-ribosyl Cyclase 1