title: IL-25 blockade inhibits metastasis in breast cancer.
abstract: Metastasis is the leading cause of death in breast cancer patients. However, the mechanisms underlying metastasis are not well understood and there is no effective treatment in the clinic. Here, we demonstrate that in MMTV-PyMT, a highly malignant spontaneous breast tumor model, IL-25 (also called IL-17E) was expressed by tumor-infiltrating CD4+T cells and macrophages. An IL-25 neutralization antibody, while not affecting primary tumor growth, substantially reduced lung metastasis. Inhibition of IL-25 resulted in decreased type 2 T cells and macrophages in the primary tumor microenvironments, both reported to enhance breast tumor invasion and subsequent metastasis to the lung. Taken together, our data suggest IL-25 blockade as a novel treatment for metastatic breast tumor.
authors.affiliation: Institute for Immunology and School of Medicine, Tsinghua University, Beijing, 100084, China.
authors.forename: Zhujun
authors.initials: Z
authors.lastname: Jiang
authors.affiliation: Institute of Translational Medicine, The First Hospital, Jilin University, Changchun, 130031, China.
authors.forename: Jingtao
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Pathology, Beijinɡ Shijitan Hospital of Capital Medical University, Beijing, 100038, China.
authors.forename: Xuemei
authors.initials: X
authors.lastname: Du
authors.affiliation: Institute of Translational Medicine, The First Hospital, Jilin University, Changchun, 130031, China.|Department of Pediatrics, The First Hospital, Jilin University, Changchun, 130031, China.
authors.forename: Hang
authors.initials: H
authors.lastname: Cheng
authors.affiliation: Institute for Immunology and School of Medicine, Tsinghua University, Beijing, 100084, China.
authors.forename: Xiaohu
authors.initials: X
authors.lastname: Wang
authors.affiliation: Institute for Immunology and School of Medicine, Tsinghua University, Beijing, 100084, China. chendong@tsinghua.edu.cn.
authors.forename: Chen
authors.initials: C
authors.lastname: Dong
mesh_terms: D000818:Animals; D000912:Antibodies, Neoplasm / Q000494:pharmacology*; D057134:Antibodies, Neutralizing / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000473:pathology; D005260:Female; D006801:Humans; D020381:Interleukin-17 / Q000037:antagonists & inhibitors / Q000235:genetics / Q000276:immunology; D007378:Interleukins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000276:immunology; D008264:Macrophages / Q000276:immunology / Q000473:pathology; D015674:Mammary Neoplasms, Animal / Q000188:drug therapy / Q000235:genetics / Q000276:immunology; D051379:Mice; D009362:Neoplasm Metastasis; D059016:Tumor Microenvironment / Q000187:drug effects / Q000235:genetics / Q000276:immunology
chemical_list: D000912:Antibodies, Neoplasm; D057134:Antibodies, Neutralizing; C486701:IL25 protein, human; D020381:Interleukin-17; D007378:Interleukins; C442281:Mydgf protein, mouse
keywords: IL-25; MMTV-PyMT; breast cancer; metastasis