title: Cytogenetic Resources and Information.
abstract: The main databases devoted stricto sensu to cancer cytogenetics are the "Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer" ( http://cgap.nci.nih.gov/Chromosomes/Mitelman ), the "Atlas of Genetics and Cytogenetics in Oncology and Haematology" ( http://atlasgeneticsoncology.org ), and COSMIC ( http://cancer.sanger.ac.uk/cosmic ).However, being a complex multistep process, cancer cytogenetics are broadened to "cytogenomics," with complementary resources on: general databases (nucleic acid and protein sequences databases; cartography browsers: GenBank, RefSeq, UCSC, Ensembl, UniProtKB, and Entrez Gene), cancer genomic portals associated with recent international integrated programs, such as TCGA or ICGC, other fusion genes databases, array CGH databases, copy number variation databases, and mutation databases. Other resources such as the International System for Human Cytogenomic Nomenclature (ISCN), the International Classification of Diseases for Oncology (ICD-O), and the Human Gene Nomenclature Database (HGNC) allow a common language.Data within the scientific/medical community should be freely available. However, most of the institutional stakeholders are now gradually disengaging, and well-known databases are forced to beg or to disappear (which may happen!).
authors.affiliation: Haematological Cancer Genetics & Stem Cell Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.
authors.forename: Etienne
authors.initials: E
authors.lastname: De Braekeleer
authors.affiliation: Medical Genetics, Department of Medical Information, University Hospital, 86021, Poitiers, France. jean-loup.huret@chu-poitiers.fr.
authors.forename: Jean-Loup
authors.initials: JL
authors.lastname: Huret
authors.affiliation: Laboratoire CERBA, 95310, Saint Ouen l'Aumone, France.
authors.forename: Hossain
authors.initials: H
authors.lastname: Mossafa
authors.affiliation: UMR 1170 INSERM, Gustave Roussy, 114 rue Edouard Vaillant, 94805, Villejuif, France. dessen@igr.fr.
authors.forename: Philippe
authors.initials: P
authors.lastname: Dessen
mesh_terms: D002869:Chromosome Aberrations; D055028:Comparative Genomic Hybridization; D019295:Computational Biology / Q000379:methods*; D020732:Cytogenetic Analysis / Q000379:methods; D003582:Cytogenetics / Q000379:methods*; D030541:Databases, Genetic; D015321:Gene Rearrangement; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D009154:Mutation; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics; D012984:Software; D014584:User-Computer Interface; D064878:Web Browser
keywords: Atlas of Genetics and Cytogenetics in Oncology and Haematology; COSMIC; Cancer; Cytogenetic; Database; Ensembl; HGNC; ICD-O; Mitelman database; UCSC