title: Metal-Free, Site-Selective Addition to Ynones: An Approach to Synthesize Substituted Quinoline Derivatives.
abstract: An efficient two component cycloaddition reaction to synthesize various substituted quinoline derivatives was developed. Ynone 1 was functionalizated by N-oxide attacking the C3-oxetium site and C3-site regioselectively to give 3 and 4. Analogues 3k and 4v have a high binding constant with Hg2+in CH3CN.
authors.affiliation: Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Science, Northwest A&F University , 3 Taicheng Road, Yangling, 712100, Shaanxi, P. R. China.
authors.forename: Zi-Sheng
authors.initials: ZS
authors.lastname: Chen
authors.affiliation: Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Science, Northwest A&F University , 3 Taicheng Road, Yangling, 712100, Shaanxi, P. R. China.
authors.forename: Fang
authors.initials: F
authors.lastname: Yang
authors.affiliation: Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Science, Northwest A&F University , 3 Taicheng Road, Yangling, 712100, Shaanxi, P. R. China.
authors.forename: Huibo
authors.initials: H
authors.lastname: Ling
authors.affiliation: Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Science, Northwest A&F University , 3 Taicheng Road, Yangling, 712100, Shaanxi, P. R. China.
authors.forename: Mengxue
authors.initials: M
authors.lastname: Li
authors.affiliation: Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Science, Northwest A&F University , 3 Taicheng Road, Yangling, 712100, Shaanxi, P. R. China.
authors.forename: Jin-Ming
authors.initials: JM
authors.lastname: Gao
authors.affiliation: Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Science, Northwest A&F University , 3 Taicheng Road, Yangling, 712100, Shaanxi, P. R. China.
authors.forename: Kegong
authors.initials: K
authors.lastname: Ji