title: Laryngo-esophageal Dysfunction-free Survival in a Preservation Protocol for T3 Laryngeal Squamous-cell Carcinoma.
abstract: We reviewed the outcomes of patients with T3 laryngeal neoplasms with a fixed hemilarynx, a large gross tumor volume or a subglottic extension (SGE), treated with a laryngeal-preservation protocol with induction chemotherapy.
  
  
  
  The study end-points were laryngo-esophageal dysfunction-free survival (LEDFS), laryngectomy-free survival (LFS), overall survival (OS), and disease-free survival (DFS).
  
  
  
  A total of 104 patients were included. The 2-year and 5-year OS rates were 70.4% and 54.5%, respectively. OS and DFS were independent of the treatment modality in the whole cohort (p=0.6546 and p=0.3006, respectively) and in patients with SGE (p=0.529 and p=0.255, respectively). The 2-year and 5-year LEDFS rates were 44.3% and 28.2%, respectively. LEDFS was not associated with initial hemilaryngeal fixation or SGE (p=0.5772 and p=0.0623, respectively).
  
  
  
  Chemoselection is feasible without compromised oncological or functional outcomes in patients with an initially fixed hemilarynx or subglottic extension.
authors.affiliation: Department of Head and Neck Oncology, Gustave Roussy Institute, Villejuif, France Philippe.gorphe@gustaveroussy.fr.
authors.forename: Philippe
authors.initials: P
authors.lastname: Gorphe
authors.affiliation: Department of Medical Oncology, Gustave Roussy Institute, Villejuif, France.
authors.forename: Margarida
authors.initials: M
authors.lastname: Matias
authors.affiliation: Department of Head and Neck Oncology, Gustave Roussy Institute, Villejuif, France.
authors.forename: Caroline
authors.initials: C
authors.lastname: Even
authors.affiliation: Department of Medical Oncology, Gustave Roussy Institute, Villejuif, France.
authors.forename: Charles
authors.initials: C
authors.lastname: Ferte
authors.affiliation: Department of Radiology, Gustave Roussy Institute, Villejuif, France.
authors.forename: François
authors.initials: F
authors.lastname: Bidault
authors.affiliation: Department of Radiology, Gustave Roussy Institute, Villejuif, France.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Garcia
authors.affiliation: Department of Head and Neck Oncology, Gustave Roussy Institute, Villejuif, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Temam
authors.affiliation: Department of Radiotherapy, Gustave Roussy Institute, Villejuif, France.
authors.forename: France
authors.initials: F
authors.lastname: Nguyen
authors.affiliation: Department of Radiotherapy, Gustave Roussy Institute, Villejuif, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Blanchard
authors.affiliation: Department of Radiotherapy, Gustave Roussy Institute, Villejuif, France.
authors.forename: Yungan
authors.initials: Y
authors.lastname: Tao
authors.affiliation: Department of Head and Neck Oncology, Gustave Roussy Institute, Villejuif, France.
authors.forename: François
authors.initials: F
authors.lastname: Janot
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000503:physiopathology / Q000601:surgery*; D002985:Clinical Protocols; D004947:Esophagus / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000503:physiopathology / Q000601:surgery*; D007830:Larynx / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D016019:Survival Analysis
keywords: Laryngeal neoplasm; fixed larynx; induction chemotherapy; laryngeal preservation; laryngectomy; radiotherapy; subglottic extension