title: Impact of Lactobacillus fermentum and dairy lipids in the maternal diet on the fatty acid composition of pups' brain and peripheral tissues.
abstract: The aim of the study was to determine the effect of maternal diets administered since day 1 of gestation and containing dairy lipids or vegetable oils differing in the supply of n-3 polyunsaturated fatty acids (n-3 PUFAs) (equilibrated or deficient) and of Lactobacillus fermentum (L. fermentum) on the docosahexaenoic acid (DHA) accretion in the pups at postnatal day 14 in the prefrontal cortex (PFC) and hippocampus (HC) for brain structures and in the liver and adipose tissue for peripheral tissues. Maternal milk fatty acid composition was also assessed by analyzing the fatty acid composition of the gastric content of the pups. DHA was higher in mice supplemented with L. fermentum than in mice in the deficient group in HC and PFC and also in liver and adipose tissue. This increase could be linked to the slight but significant increase in C18:3n-3 in the maternal milk. This proportion was comparable in the dairy lipid group for which the brain DHA level was the highest. L. fermentum may have a key role in the protection of the brain during the perinatal period via the neuronal accretion of n-3 PUFAs, especially during n-3 PUFA deficiency.
authors.affiliation: INRA, Nutrition et Neurobiologie Intégrée, UMR 1286, 33076 Bordeaux, France; Univ. Bordeaux, Nutrition et Neurobiologie Intégrée, UMR 1286, 33076 Bordeaux, France. Electronic address: corinne.joffre@bordeaux.inra.fr.
authors.forename: C
authors.initials: C
authors.lastname: Joffre
authors.affiliation: INRA, Nutrition et Neurobiologie Intégrée, UMR 1286, 33076 Bordeaux, France; Univ. Bordeaux, Nutrition et Neurobiologie Intégrée, UMR 1286, 33076 Bordeaux, France; Nutribrain Research and Technology transfer of Nutrition et Neurobiologie Intégrée, 33076 Bordeaux, France.
authors.forename: A L
authors.initials: AL
authors.lastname: Dinel
authors.affiliation: INRA, Nutrition et Neurobiologie Intégrée, UMR 1286, 33076 Bordeaux, France; Univ. Bordeaux, Nutrition et Neurobiologie Intégrée, UMR 1286, 33076 Bordeaux, France.
authors.forename: A
authors.initials: A
authors.lastname: Aubert
authors.affiliation: Lactalis Nutrition Europe, Torce, France.
authors.forename: C
authors.initials: C
authors.lastname: Fressange-Mazda
authors.affiliation: Lactalis Recherche et Développement, Retiers, France.
authors.forename: P
authors.initials: P
authors.lastname: Le Ruyet
authors.affiliation: INRA, Nutrition et Neurobiologie Intégrée, UMR 1286, 33076 Bordeaux, France; Univ. Bordeaux, Nutrition et Neurobiologie Intégrée, UMR 1286, 33076 Bordeaux, France.
authors.forename: S
authors.initials: S
authors.lastname: Layé
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D000833:Animals, Suckling; D001921:Brain / Q000378:metabolism*; D019587:Dietary Supplements; D004281:Docosahexaenoic Acids / Q000378:metabolism*; D005227:Fatty Acids / Q000032:analysis; D005260:Female; D006624:Hippocampus / Q000378:metabolism; D052197:Limosilactobacillus fermentum / Q000502:physiology*; D008099:Liver / Q000378:metabolism*; D039382:Maternal Nutritional Physiological Phenomena; D051379:Mice; D008892:Milk / Q000737:chemistry*; D010938:Plant Oils / Q000008:administration & dosage*; D017397:Prefrontal Cortex / Q000378:metabolism; D011247:Pregnancy; D014018:Tissue Distribution
chemical_list: D005227:Fatty Acids; D010938:Plant Oils; D004281:Docosahexaenoic Acids
keywords: Adipose tissue; Brain; DHA accretion; Lactobacillus fermentum; Liver; Perinatal period