title: Compatibility of phospholipid liposomal spray with silicone hydrogel contact lens wear.
abstract: OBJECTIVE
  To assess the effects of two weeks of regular phospholipid liposomal spray application on lipid layer grade, tear film stability, subjective comfort, visual acuity, and lipid deposition in silicone hydrogel contact lens wearers.
  
  
  METHODS
  Thirty-one existing contact lens wearers were enrolled and fitted with two week planned replacement silicone hydrogel contact lenses (Acuvue®Oasys®) in a prospective, randomized, paired-eye, investigator-masked trial. A phospholipid liposomal spray (Tears Again®) was applied to one eye (randomized) four times daily for two weeks. LogMAR high contrast visual acuity (VA), low contrast glare acuity (LCGA), non-invasive tear film break-up time (NIBUT), and lipid layer grade (LLG) were measured at baseline and day 14, in both treated and control eyes. Subjective comfort relative to baseline, and spectrofluorophotometric assessment of contact lens surface lipid deposition were also assessed on day 14.
  
  
  RESULTS
  All measurements did not differ at baseline between treated and control eyes. Lipid layer thickness and tear film stability were increased on day 14 in treated eyes (all p<0.05), but not in control eyes (all p>0.05). A greater proportion of participants reported improved comfort in the treated eye relative to the control eye (p=0.002). There were no significant differences in visual acuity or in contact lens surface lipid deposition, between treated and control eyes, on day 14 (all p>0.05).
  
  
  CONCLUSIONS
  The phospholipid liposomal spray increased tear film stability, lipid layer thickness and subjective comfort in silicone hydrogel contact lens wearers, without adversely affecting visual acuity or contact lens surface lipid deposition.
authors.affiliation: Department of Ophthalmology, New Zealand National Eye Centre, The University of Auckland, New Zealand.
authors.forename: Michael T M
authors.initials: MT
authors.lastname: Wang
authors.affiliation: Department of Ophthalmology and School of Optometry and Vision Science, New Zealand National Eye Centre, The University of Auckland, New Zealand.
authors.forename: Kalaivarny
authors.initials: K
authors.lastname: Ganesalingam
authors.affiliation: Department of Ophthalmology and School of Optometry and Vision Science, New Zealand National Eye Centre, The University of Auckland, New Zealand.
authors.forename: Chee Seang
authors.initials: CS
authors.lastname: Loh
authors.affiliation: Department of Ophthalmology and School of Optometry and Vision Science, New Zealand National Eye Centre, The University of Auckland, New Zealand.
authors.forename: Trisha
authors.initials: T
authors.lastname: Alberquerque
authors.affiliation: Department of Ophthalmology and School of Optometry and Vision Science, New Zealand National Eye Centre, The University of Auckland, New Zealand.
authors.forename: Suhaila
authors.initials: S
authors.lastname: Al-Kanani
authors.affiliation: Department of Ophthalmology, New Zealand National Eye Centre, The University of Auckland, New Zealand.
authors.forename: Stuti L
authors.initials: SL
authors.lastname: Misra
authors.affiliation: Department of Ophthalmology, New Zealand National Eye Centre, The University of Auckland, New Zealand. Electronic address: jp.craig@auckland.ac.nz.
authors.forename: Jennifer P
authors.initials: JP
authors.lastname: Craig
mesh_terms: D000293:Adolescent; D000327:Adsorption; D000328:Adult; D000336:Aerosols / Q000008:administration & dosage / Q000737:chemistry; D001672:Biocompatible Materials / Q000008:administration & dosage / Q000737:chemistry; D003263:Contact Lenses, Hydrophilic; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005260:Female; D006801:Humans; D008081:Liposomes / Q000008:administration & dosage* / Q000737:chemistry; D008297:Male; D008422:Materials Testing; D010743:Phospholipids / Q000008:administration & dosage* / Q000737:chemistry; D020034:Silicone Gels / Q000737:chemistry*; D013499:Surface Properties; D013666:Tears / Q000737:chemistry* / Q000187:drug effects; D014792:Visual Acuity / Q000187:drug effects*; D055815:Young Adult
chemical_list: D000336:Aerosols; D001672:Biocompatible Materials; D008081:Liposomes; D010743:Phospholipids; D020034:Silicone Gels
keywords: Contact lens; Lipid layer; Liposomal spray; Phospholipid; Silicone hydrogel; Tear film