title: Incorporation of large guest molecules into liposomes via chemical reactions in lipid membranes.
abstract: The incorporation of hydrophobic guest molecules into lipid membranes by the exchange of the guest molecule from a cyclodextrin (CDx) complex to a liposome is limited to guest molecules that can be included in CDxs. To solve this problem, large guest molecules were incorporated into liposomes by chemical reactions of guest molecules in lipid membranes. Stable lipid-membrane-incorporated fullerene derivatives with large substituent(s) were prepared by Diels-Alder reactions in lipid membranes.
authors.affiliation: Department of Applied Chemistry, Graduate School of Engineering, Hiroshima University, Higashi-Hiroshima 739-8527, Japan. aikeda@hiroshima-u.ac.jp.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Tsuchiya
authors.affiliation: Department of Applied Chemistry, Graduate School of Engineering, Hiroshima University, Higashi-Hiroshima 739-8527, Japan. aikeda@hiroshima-u.ac.jp.
authors.forename: Kouta
authors.initials: K
authors.lastname: Sugikawa
authors.affiliation: Department of Applied Chemistry, Graduate School of Engineering, Hiroshima University, Higashi-Hiroshima 739-8527, Japan. aikeda@hiroshima-u.ac.jp.
authors.forename: Masafumi
authors.initials: M
authors.lastname: Ueda
authors.affiliation: Department of Applied Chemistry, Graduate School of Engineering, Hiroshima University, Higashi-Hiroshima 739-8527, Japan. aikeda@hiroshima-u.ac.jp.
authors.forename: Atsushi
authors.identifier: http://orcid.org/0000-0003-3492-3455
authors.initials: A
authors.lastname: Ikeda
mesh_terms: D003505:Cyclodextrins / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D008051:Lipid Bilayers / Q000138:chemical synthesis / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D003505:Cyclodextrins; D008051:Lipid Bilayers; D008081:Liposomes