title: Clustering Algorithms: Their Application to Gene Expression Data.
abstract: Gene expression data hide vital information required to understand the biological process that takes place in a particular organism in relation to its environment. Deciphering the hidden patterns in gene expression data proffers a prodigious preference to strengthen the understanding of functional genomics. The complexity of biological networks and the volume of genes present increase the challenges of comprehending and interpretation of the resulting mass of data, which consists of millions of measurements; these data also inhibit vagueness, imprecision, and noise. Therefore, the use of clustering techniques is a first step toward addressing these challenges, which is essential in the data mining process to reveal natural structures and identify interesting patterns in the underlying data. The clustering of gene expression data has been proven to be useful in making known the natural structure inherent in gene expression data, understanding gene functions, cellular processes, and subtypes of cells, mining useful information from noisy data, and understanding gene regulation. The other benefit of clustering gene expression data is the identification of homology, which is very important in vaccine design. This review examines the various clustering algorithms applicable to the gene expression data in order to discover and provide useful knowledge of the appropriate clustering technique that will guarantee stability and high degree of accuracy in its analysis procedure.
authors.affiliation: Department of Computer and Information Sciences, Covenant University, Ota, Ogun State, Nigeria.; Covenant University Bioinformatics Research (CUBRe), Covenant University, Ota, Ogun State, Nigeria.
authors.forename: Jelili
authors.initials: J
authors.lastname: Oyelade
authors.affiliation: Department of Computer and Information Sciences, Covenant University, Ota, Ogun State, Nigeria.; Covenant University Bioinformatics Research (CUBRe), Covenant University, Ota, Ogun State, Nigeria.
authors.forename: Itunuoluwa
authors.initials: I
authors.lastname: Isewon
authors.affiliation: Department of Computer and Information Sciences, Covenant University, Ota, Ogun State, Nigeria.
authors.forename: Funke
authors.initials: F
authors.lastname: Oladipupo
authors.affiliation: Department of Computer and Information Sciences, Covenant University, Ota, Ogun State, Nigeria.
authors.forename: Olufemi
authors.initials: O
authors.lastname: Aromolaran
authors.affiliation: Department of Computer and Information Sciences, Covenant University, Ota, Ogun State, Nigeria.
authors.forename: Efosa
authors.initials: E
authors.lastname: Uwoghiren
authors.affiliation: Department of Computer and Information Sciences, Covenant University, Ota, Ogun State, Nigeria.
authors.forename: Faridah
authors.initials: F
authors.lastname: Ameh
authors.affiliation: Department of Computer Science and Information Technology, Bells University of Technology, Ota, Ogun State, Nigeria.
authors.forename: Moses
authors.initials: M
authors.lastname: Achas
authors.affiliation: Department of Computer and Information Sciences, Covenant University, Ota, Ogun State, Nigeria.; Covenant University Bioinformatics Research (CUBRe), Covenant University, Ota, Ogun State, Nigeria.
authors.forename: Ezekiel
authors.initials: E
authors.lastname: Adebiyi
keywords: bioinformatics; biological process; clustering algorithm; gene expression data; homology