title: Serum Soluble Fms-Like Tyrosine Kinase 1 (sFlt-1) Predicts the Severity of Acute Pancreatitis.
abstract: Organ failure is the most important determinant of the severity of acute pancreatitis (AP). Soluble fms-like tyrosine kinase 1 (sFlt-1) is positively associated with organ failure in sepsis. Our aim was to evaluate the diagnostic utility of automated sFlt-1 measurements for early prediction of AP severity. Adult patients (66) with AP were recruited, including 46 with mild (MAP), 15 with moderately-severe (MSAP) and 5 with severe AP (SAP). Serum and urine samples were collected twice. Serum sFlt-1 was measured with automated electrochemiluminescence immunoassay. Serum concentrations of sFlt-1 were significantly higher in patients with MSAP and SAP as compared to MAP. SAP patients had the highest concentrations. At 24 and 48 h, sFlt-1 positively correlated with inflammatory markers (leukocyte count, C-reactive protein), kidney function (creatinine, urea, cystatin C, serum and urine neutrophil gelatinase-associated lipocalin, urine albumin/creatinine ratio), D-dimer and angiopoietin-2. sFlt-1 positively correlated with the bedside index of severity in AP (BISAP) score and the duration of hospital stay. Serum sFlt-1 above 139 pg/mL predicted more severe AP (MSAP + SAP). In the early phase of AP, sFlt-1 is positively associated with the severity of AP and predicts organ failure, in particular kidney failure. Serum sFlt-1 may be a practical way to improve early assessment of AP severity.
authors.affiliation: Department of Medical Diagnostics, Jagiellonian University Medical College, 30-688 Kraków, Poland. paulina.dumnicka@uj.edu.pl.
authors.forename: Paulina
authors.initials: P
authors.lastname: Dumnicka
authors.affiliation: Surgery Department, The District Hospital, 34-200 Sucha Beskidzka, Poland. msporek1983@gmail.com.|Department of Anatomy, Jagiellonian University Medical College, 31-034 Kraków, Poland. msporek1983@gmail.com.
authors.forename: Mateusz
authors.initials: M
authors.lastname: Sporek
authors.affiliation: Department of Diagnostics, University Hospital, 31-501 Kraków, Poland. mbmazur@cyf-kr.edu.pl.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Mazur-Laskowska
authors.affiliation: Department of Physiology, Jagiellonian University Medical College, 31-531 Kraków, Poland. piotr.ceranowicz@uj.edu.pl.
authors.forename: Piotr
authors.initials: P
authors.lastname: Ceranowicz
authors.affiliation: Chair and Department of Nephrology, Jagiellonian University Medical College, 31-501 Kraków, Poland. marek.kuzniewski@uj.edu.pl.
authors.forename: Marek
authors.initials: M
authors.lastname: Kuźniewski
authors.affiliation: Department of Medical Diagnostics, Jagiellonian University Medical College, 30-688 Kraków, Poland. ryszard.drozdz@uj.edu.pl.
authors.forename: Ryszard
authors.initials: R
authors.lastname: Drożdż
authors.affiliation: Department of Theory of Sport and Kinesiology, Faculty of Physical Education and Sport, University of Physical Education, 31-571 Kraków, Poland. tadek@ambrozy.pl.
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Ambroży
authors.affiliation: Department of Pharmacology, Jagiellonian University Medical College, 31-531 Kraków, Poland. mfolszan@cyf-kr.edu.pl.
authors.forename: Rafał
authors.initials: R
authors.lastname: Olszanecki
authors.affiliation: Department of Diagnostics, Chair of Clinical Biochemistry, Jagiellonian University Medical College, 31-501 Kraków, Poland. mbkusnie@cyf-kr.edu.pl.
authors.forename: Beata
authors.initials: B
authors.lastname: Kuśnierz-Cabala
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D042702:Angiopoietin-2 / Q000097:blood; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000097:blood* / Q000473:pathology*; D012720:Severity of Illness Index; D013997:Time Factors; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000097:blood*
chemical_list: D042702:Angiopoietin-2; D015415:Biomarkers; C501162:FLT1 protein, human; D040281:Vascular Endothelial Growth Factor Receptor-1
keywords: acute pancreatitis; angiopoietin-2; diagnostic utility; endothelial dysfunction; vascular endothelial growth factor receptor 1