title: Copper-Catalyzed Decarboxylative Difluoroalkylation and Perfluoroalkylation of α,β-Unsaturated Carboxylic Acids.
abstract: Copper-catalyzed decarboxylative difluoroalkylation and perfluoroalkylation of α,β-unsaturated carboxylic acids is described. Promoted by dialkyl phosphite, this novel reaction affords fluoroalkylated motifs with excellent stereoselectivity and broad substrate scope under mild reaction conditions from readily available fluoroalkyl iodides and bromides. Preliminary mechanism study suggests that radical pathway was involved in the catalytic cycle and dialkyl phosphite had played an indispensable role in this reaction.
authors.affiliation: Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology , Guangzhou, Guangdong 510640, China.
authors.forename: Yin-Long
authors.initials: YL
authors.lastname: Lai
authors.affiliation: Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology , Guangzhou, Guangdong 510640, China.
authors.forename: Dian-Zhao
authors.initials: DZ
authors.lastname: Lin
authors.affiliation: Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology , Guangzhou, Guangdong 510640, China.
authors.forename: Jing-Mei
authors.identifier: 0000-0003-2861-3856
authors.initials: JM
authors.lastname: Huang