title: Overview of the predictive value of quantitative 18 FDG PET in head and neck cancer treated with chemoradiotherapy.
abstract: 18 F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) allows to quantify the metabolic activity of a tumor (glycolysis) and has become a reference tool in oncology for the staging, restaging, radiotherapy planning and monitoring response in many cancers. Quantitative analyses have been introduced in order to overcome some of the limits of the visual methods, allowing an easier and more objective comparison of the inter- and intra-patients variations. The aims of this review were to report available evidences on the clinical value of quantitative PET/CT parameters in HNC. Forty-five studies, for a total of 2928 patients, were analyzed. Most of the data available dealt with the intensity of the metabolism, calculated from the Standard Uptake Value (SUV). Metabolic Tumor Volume (MTV) was well correlated with overall survival and disease free survival, with a higher predictive value than the maximum SUV. Spatial distribution of metabolism and textural analyses seems promising.
authors.affiliation: Radiotherapy Department, CHUV, Lausanne, Switzerland; INSERM, U1099, Rennes, F-35000, France; Université de Rennes 1, LTSI, Rennes, F-35000, France. Electronic address: j.castelli@rennes.unicancer.fr.
authors.forename: J
authors.initials: J
authors.lastname: Castelli
authors.affiliation: Radiotherapy Department, CHUV, Lausanne, Switzerland.
authors.forename: B
authors.initials: B
authors.lastname: De Bari
authors.affiliation: University of Applied Sciences Western Switzerland, 3960 Sierre, Switzerland; Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne VD, Switzerland.
authors.forename: A
authors.initials: A
authors.lastname: Depeursinge
authors.affiliation: INSERM, U1099, Rennes, F-35000, France; Université de Rennes 1, LTSI, Rennes, F-35000, France.
authors.forename: A
authors.initials: A
authors.lastname: Simon
authors.affiliation: Nuclear Medecine Department, Centre Eugene Marquis, Rennes, F-35000, France.
authors.forename: A
authors.initials: A
authors.lastname: Devillers
authors.affiliation: INSERM, U1099, Rennes, F-35000, France; Université de Rennes 1, LTSI, Rennes, F-35000, France; Keosys Medical imaging, 1 Impasse Augustin Fresnel, Saint-Herblain, F-44815, France.
authors.forename: G
authors.initials: G
authors.lastname: Roman Jimenez
authors.affiliation: Nuclear Medecine Department, CHUV, Switzerland.
authors.forename: J
authors.initials: J
authors.lastname: Prior
authors.affiliation: Radiotherapy Department, CHUV, Lausanne, Switzerland.
authors.forename: M
authors.initials: M
authors.lastname: Ozsahin
authors.affiliation: INSERM, U1099, Rennes, F-35000, France; Université de Rennes 1, LTSI, Rennes, F-35000, France; Radiotherapy Department, Centre Eugene Marquis, Rennes, F-35000, France.
authors.forename: R
authors.initials: R
authors.lastname: de Crevoisier
authors.affiliation: Radiotherapy Department, CHUV, Lausanne, Switzerland.
authors.forename: J
authors.initials: J
authors.lastname: Bourhis
mesh_terms: D059248:Chemoradiotherapy; D019788:Fluorodeoxyglucose F18; D006019:Glycolysis; D006258:Head and Neck Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy*; D006801:Humans; D000072078:Positron Emission Tomography Computed Tomography
chemical_list: D019788:Fluorodeoxyglucose F18
keywords: Chemoradiotherapy; Clinical outcome; Head and neck cancer; PET