title: Global vision of druggability issues: applications and perspectives.
abstract: During the preliminary stage of a drug discovery project, the lack of druggability information and poor target selection are the main causes of frequent failures. Elaborating on accurate computational druggability prediction methods is a requirement for prioritizing target selection, designing new drugs and avoiding side effects. In this review, we describe a survey of recently reported druggability prediction methods mainly based on networks, statistical pocket druggability predictions and virtual screening. An application for a frequent mutation of p53 tumor suppressor is presented, illustrating the complementarity of druggability prediction approaches, the remaining challenges and potential new drug development perspectives.
authors.affiliation: Molécules Thérapeutiques in silico (MTi), Inserm UMR-S 973, Paris, France; Paris Diderot University, Sorbonne Paris Cité, Paris, France. Electronic address: hiba.abihussein@univ-paris-diderot.fr.
authors.forename: Hiba
authors.initials: H
authors.lastname: Abi Hussein
authors.affiliation: Molécules Thérapeutiques in silico (MTi), Inserm UMR-S 973, Paris, France; Paris Diderot University, Sorbonne Paris Cité, Paris, France.
authors.forename: Colette
authors.initials: C
authors.lastname: Geneix
authors.affiliation: Molécules Thérapeutiques in silico (MTi), Inserm UMR-S 973, Paris, France; Paris Diderot University, Sorbonne Paris Cité, Paris, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Petitjean
authors.affiliation: Molécules Thérapeutiques in silico (MTi), Inserm UMR-S 973, Paris, France; Paris Diderot University, Sorbonne Paris Cité, Paris, France; Faculty of Pharmacy, Division of Pharmaceutical Chemistry and Technology, University of Helsinki, Finland.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Borrel
authors.affiliation: Molécules Thérapeutiques in silico (MTi), Inserm UMR-S 973, Paris, France; Paris Diderot University, Sorbonne Paris Cité, Paris, France.
authors.forename: Delphine
authors.initials: D
authors.lastname: Flatters
authors.affiliation: Molécules Thérapeutiques in silico (MTi), Inserm UMR-S 973, Paris, France; Paris Diderot University, Sorbonne Paris Cité, Paris, France. Electronic address: anne-claude.camproux@univ-paris-diderot.fr.
authors.forename: Anne-Claude
authors.initials: AC
authors.lastname: Camproux
mesh_terms: D001665:Binding Sites; D004247:DNA / Q000378:metabolism; D055808:Drug Discovery; D006801:Humans; D008962:Models, Theoretical; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism
chemical_list: D016159:Tumor Suppressor Protein p53; D004247:DNA