title: Characterization of enterovirus 71 infection and associated outbreak of Hand, Foot, and Mouth Disease in Shawo of China in 2012.
abstract: Infection of enterovirus 71 (EV71) and associated hand, foot, and mouth disease (HFMD) are recognized as emerging public health issues worldwide. Hundreds of thousands of children are annually infected with EV71 and develop HFMD in China alone. Studies of EV71 infection are critical to the treatment and prevention of the associated HFMD outbreaks. In this report, we studied an outbreak of 105 HFMD cases in Shawo Township of China between September to October 2012. More than 90% of cases were children younger than 9 years old, with over 50% of cases aged 3-6 years old. Laboratory studies detected a high prevalence of EV71 and suggested EV71 as the most common enterovirus causing HFMD in Shawo. Sequencing analysis showed that the EV71 strains from Shawo belong to the C4 subgenotype, and are phylogenetically more related to those from the distant city of Nanchang than those from the nearby city of Wuhan with distinct variations. More girls were found to be associated with EV71 in Shawo whereas more boys were associated with EV71 in Wuhan and Nanchang. Our studies further the understanding of the molecular epidemiological features of HFMD and infection by enteroviruses in China.
authors.affiliation: College of Life Sciences, Jinan University, Guangzhou, Guangdong 510632, China.|State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China.|School of Public Health, University of California, Berkeley, CA 94720, USA.
authors.forename: Michelle Y
authors.initials: MY
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Liu
authors.affiliation: College of Life Sciences, Jinan University, Guangzhou, Guangdong 510632, China.|Taizhou Institute of Virology, Taizhou, Jiangsu 225300, China.|Jiangsu Affynigen Biotechnologies, Inc., Taizhou, Jiangsu 225300, China.
authors.forename: Weijian
authors.initials: W
authors.lastname: Lai
authors.affiliation: State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Luo
authors.affiliation: State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China.
authors.forename: Yingle
authors.initials: Y
authors.lastname: Liu
authors.affiliation: School of Public Health, University of California, Berkeley, CA 94720, USA.
authors.forename: Gia-Phong
authors.initials: GP
authors.lastname: Vu
authors.affiliation: Taizhou Institute of Virology, Taizhou, Jiangsu 225300, China.|Jiangsu Affynigen Biotechnologies, Inc., Taizhou, Jiangsu 225300, China.
authors.forename: Zhu
authors.initials: Z
authors.lastname: Yang
authors.affiliation: School of Public Health, University of California, Berkeley, CA 94720, USA.
authors.forename: Phong
authors.initials: P
authors.lastname: Trang
authors.affiliation: College of Life Sciences, Jinan University, Guangzhou, Guangdong 510632, China.
authors.forename: Hongjian
authors.initials: H
authors.lastname: Li
authors.affiliation: State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China.
authors.forename: Jianguo
authors.initials: J
authors.lastname: Wu
mesh_terms: D017677:Age Distribution; D001483:Base Sequence; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D004196:Disease Outbreaks / Q000706:statistics & numerical data*; D029821:Enterovirus A, Human / Q000502:physiology*; D005260:Female; D005843:Geography; D006232:Hand, Foot and Mouth Disease / Q000453:epidemiology* / Q000821:virology*; D006801:Humans; D008297:Male; D010802:Phylogeny; D012621:Seasons; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA