title: Choroidal and skin metastases from colorectal cancer.
abstract: Choroidal and skin metastasis of colon cancer is rare. In women, the frequency of cutaneous metastasis from colon cancer as the primary lesion in is 9% and skin metastasis occurs in 0.81% of all colorectal cancers. We report a patient with colonic adenocarcinoma who presented with visual disorder in her right eye and scalp pain as her initial symptoms. Contrast-enhance orbital magnetic resonance imaging with fat suppression revealed an infrabulbar mass, and skin biopsy of the posterior parietal scalp confirmed adenocarcinoma. These symptoms were diagnosed as being caused by choroidal and skin metastases of colonic adenocarcinoma. We started palliative chemotherapy with oral capecitabine (1000 mg/m2, twice a day, on days 1-14) every 3 wk, which was effective at shrinking the brain masses and improving the visual disorder. This is the first report that capecitabine is effective at reducing a choroidal and cutaneous metastatic lesion from right-sided colorectal cancer.
authors.affiliation: Joo Young Ha, Edward Hynseung Oh, Moon Ki Jung, Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul 156-861, South Korea.
authors.forename: Joo Young
authors.initials: JY
authors.lastname: Ha
authors.affiliation: Joo Young Ha, Edward Hynseung Oh, Moon Ki Jung, Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul 156-861, South Korea.
authors.forename: Edward Hynseung
authors.initials: EH
authors.lastname: Oh
authors.affiliation: Joo Young Ha, Edward Hynseung Oh, Moon Ki Jung, Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul 156-861, South Korea.
authors.forename: Moon Ki
authors.initials: MK
authors.lastname: Jung
authors.affiliation: Joo Young Ha, Edward Hynseung Oh, Moon Ki Jung, Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul 156-861, South Korea.
authors.forename: Song Ee
authors.initials: SE
authors.lastname: Park
authors.affiliation: Joo Young Ha, Edward Hynseung Oh, Moon Ki Jung, Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul 156-861, South Korea.
authors.forename: Ji Tak
authors.initials: JT
authors.lastname: Kim
authors.affiliation: Joo Young Ha, Edward Hynseung Oh, Moon Ki Jung, Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul 156-861, South Korea.
authors.forename: In Gyu
authors.initials: IG
authors.lastname: Hwang
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000556:secondary*; D000284:Administration, Oral; D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D001706:Biopsy; D000069287:Capecitabine / Q000008:administration & dosage; D002830:Choroid Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000556:secondary*; D015179:Colorectal Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D018450:Disease Progression; D004334:Drug Administration Schedule; D017809:Fatal Outcome; D005260:Female; D006258:Head and Neck Neoplasms / Q000188:drug therapy / Q000556:secondary*; D006801:Humans; D008279:Magnetic Resonance Imaging; D012535:Scalp / Q000473:pathology*; D012878:Skin Neoplasms / Q000188:drug therapy / Q000556:secondary*; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D047368:Tumor Burden
chemical_list: D000964:Antimetabolites, Antineoplastic; D000069287:Capecitabine
keywords: Capecitabine; Choroid cancer; Colon cancer; Skin cancer