title: Cyclins A, B, E and p27 in Endometrial Endometrioid Adenocarcinoma.
abstract: We have previously shown that cyclin A, B and E hold prognostic significance in endometrial endometrioid adenocarcinoma. The aim of this study was to investigate the impact of cyclin-dependent kinase inhibitor p27 on cancer-specific survival and other clinicopathological variables, as well as further analyze the relationship between p27 and cyclins A, B and E and their combined relation to prognosis in the disease.
  
  
  
  The study comprised of 211 patients surgically treated for endometrial endometrioid adenocarcinoma at the Oulu University Hospital between 1992 and 2000. Tissue samples were immunohistochemically stained for cyclins A, B and E, as well as p27. Clinicopathological data were retrospectively retrieved from the patients' records.
  
  
  
  In this study, universally low cyclin expression was found to be an independent, favorable prognostic factor in endometrial endometrioid adenocarcinoma. A strong correlation was found between cyclin A and cyclin B expression and weaker correlations between other cyclin and p27 pairs. Nuclear p27 expression correlated with stage and produced near-significant results in univariate survival analysis.
  
  
  
  Combining the expression level of different cyclins may be useful in determining the prognosis in endometrial cancer. Unfortunately, it remains unclear whether high p27 expression is a poor or a favorable prognostic factor. Further large-scale studies are required to assess the effects of cyclins and p27 in endometrial cancer.
authors.affiliation: Department of Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland.
authors.forename: Simi
authors.initials: S
authors.lastname: Santala
authors.affiliation: Department of Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland.
authors.forename: Anne
authors.initials: A
authors.lastname: Talvensaari-Mattila
authors.affiliation: Department of Pathology, Oulu University Hospital, Oulu, Finland.|Department of Pathology and Forensic Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, School of Medicine, Cancer Centre of Eastern Finland, University of Eastern Finland, Kuopio, Finland.
authors.forename: Ylermi
authors.initials: Y
authors.lastname: Soini
authors.affiliation: Department of Pathology, Oulu University Hospital, Oulu, Finland.
authors.forename: Paula
authors.initials: P
authors.lastname: Kuvaja
authors.affiliation: Department of Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland markku.santala@oulu.fi.
authors.forename: Markku
authors.initials: M
authors.lastname: Santala
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018269:Carcinoma, Endometrioid / Q000378:metabolism*; D050760:Cyclin-Dependent Kinase Inhibitor p27 / Q000378:metabolism*; D016213:Cyclins / Q000378:metabolism*; D016889:Endometrial Neoplasms / Q000378:metabolism*; D005260:Female; D006801:Humans; D008875:Middle Aged
chemical_list: D016213:Cyclins; D050760:Cyclin-Dependent Kinase Inhibitor p27
keywords: CDKs; cyclins; endometrial adenocarcinoma; p27; prognosis