title: Detection of Drug-Responsive T-Lymphocytes in a Case of Fatal Antituberculosis Drug-Related Liver Injury.
abstract: Antituberculosis (TB) drug exposure is associated with a mild elevation of liver enzymes that occasionally develops into severe liver injury. Herein, we identify ethambutol- and rifampicin-specific CD4+ and CD8+ T-cell clones in a patient with fatal anti TB-related liver injury. The clones were activated to proliferate and secrete IFN-γ, Il-13, and granzyme B following drug treatment. Drug-responsive T-cells may contribute to the pathogenesis of antituberculosis-related liver failure.
authors.affiliation: Department of Molecular and Clinical Pharmacology, University of Liverpool , Sherrington Building, Ashton Street, Liverpool L69 3GE, England.
authors.forename: Toru
authors.initials: T
authors.lastname: Usui
authors.affiliation: Department of Respiratory Medicine, St James's Hospital , Beckett Street, Leeds LS9 7TF, England.
authors.forename: Paul
authors.initials: P
authors.lastname: Whitaker
authors.affiliation: Department of Molecular and Clinical Pharmacology, University of Liverpool , Sherrington Building, Ashton Street, Liverpool L69 3GE, England.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Meng
authors.affiliation: Department of Respiratory Medicine, St James's Hospital , Beckett Street, Leeds LS9 7TF, England.
authors.forename: John
authors.initials: J
authors.lastname: Watson
authors.affiliation: Department of Molecular and Clinical Pharmacology, University of Liverpool , Sherrington Building, Ashton Street, Liverpool L69 3GE, England.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Antoine
authors.affiliation: Department of Molecular and Clinical Pharmacology, University of Liverpool , Sherrington Building, Ashton Street, Liverpool L69 3GE, England.
authors.forename: Neil S
authors.initials: NS
authors.lastname: French
authors.affiliation: Department of Molecular and Clinical Pharmacology, University of Liverpool , Sherrington Building, Ashton Street, Liverpool L69 3GE, England.
authors.forename: B Kevin
authors.initials: BK
authors.lastname: Park
authors.affiliation: Department of Molecular and Clinical Pharmacology, University of Liverpool , Sherrington Building, Ashton Street, Liverpool L69 3GE, England.
authors.forename: Dean J
authors.initials: DJ
authors.lastname: Naisbitt
mesh_terms: D000995:Antitubercular Agents / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000276:immunology
chemical_list: D000995:Antitubercular Agents