title: Recurrent Cytogenetic Abnormalities in Multiple Myeloma.
abstract: Multiple myeloma is a heterogeneous disease. Its chromosomal abnormalities have been extensively studied with a view to accurate prognostication and personalized therapy. Here, we describe the techniques commonly employed for elucidating chromosomal aberrations, prognostic impact of recurrent chromosomal abnormalities, and recently updated risk stratification systems.
authors.affiliation: Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, 30-32 Ngan Shing Street, Shatin, Hong Kong. nelsonchan@cuhk.edu.hk.
authors.forename: Nelson Chun Ngai
authors.initials: NC
authors.lastname: Chan
authors.affiliation: Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, 30-32 Ngan Shing Street, Shatin, Hong Kong.
authors.forename: Natalie Pui Ha
authors.initials: NP
authors.lastname: Chan
mesh_terms: D002869:Chromosome Aberrations; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain; D056726:Genetic Association Studies; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007399:Interphase / Q000235:genetics; D058990:Molecular Targeted Therapy; D009101:Multiple Myeloma / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics* / Q000401:mortality; D009367:Neoplasm Staging; D011123:Polyploidy; D011379:Prognosis; D012306:Risk; D014178:Translocation, Genetic
keywords: Conventional cytogenetics; Hyperdiploid; IGH translocation; Interphase FISH; Myeloma; Risk stratification