title: Genomics of Colorectal Cancer in African Americans.
abstract: Genome-wide studies are increasingly becoming a must, especially for complex diseases such as cancer where multiple genes and diverse molecular mechanisms are known to be involved in genes' function alteration. In this review, we report our latest genomic and epigenomic findings in African-American colorectal cancer patients. This population suffers a higher burden of the disease and most investigators in this field are looking for the underlying genetic and epigenetic targets that might be responsible for this disparity. We here report genome-wide copy number variations, single nucleotide mutations and DNA methylation findings that might be specific to this population.
authors.affiliation: Pathology Department, Howard University College of Medicine, Gastroenterology Division and Cancer Center, Washington DC, USA.
authors.forename: Hassan
authors.initials: H
authors.lastname: Brim
authors.affiliation: Howard University College of Medicine, Department of Medicine and Cancer Center, 2041 Georgia Avenue, Washington, DC, 20060, USA.
authors.forename: Hassan
authors.initials: H
authors.lastname: Ashktorab
keywords: Colorectal cancer; Copy number; DNA methylation; Epigenomics; Exome sequencing; Genomics; Single nucleotide mutations