title: The intricate dance of post-translational modifications in the rhythm of life.
abstract: Endogenous biological rhythms with approximately 24-h periodicity are generated by the circadian clock, in which clock genes coordinate with one another and form a transcriptional-translational negative feedback loop. The precision of the circadian clock is further regulated by multiple post-translational modifications (PTMs), including phosphorylation, ubiquitination, acetylation and SUMOylation. Here, we review current understanding of the regulatory mechanisms of the core clock proteins by PTMs in the mammalian circadian clock.
authors.affiliation: Kavli Institute for Fundamental Neuroscience; Weill Institute of Neurosciences; Howard Hughes Medical Institute; and Department of Neurology, University of California, San Francisco, San Francisco, California USA.
authors.forename: Arisa
authors.initials: A
authors.lastname: Hirano
authors.affiliation: Kavli Institute for Fundamental Neuroscience; Weill Institute of Neurosciences; Howard Hughes Medical Institute; and Department of Neurology, University of California, San Francisco, San Francisco, California USA.
authors.forename: Ying-Hui
authors.initials: YH
authors.lastname: Fu
authors.affiliation: Kavli Institute for Fundamental Neuroscience; Weill Institute of Neurosciences; Howard Hughes Medical Institute; and Department of Neurology, University of California, San Francisco, San Francisco, California USA.
authors.forename: Louis J
authors.initials: LJ
authors.lastname: Ptáček
mesh_terms: D000818:Animals; D057906:Circadian Clocks; D002940:Circadian Rhythm; D056925:Circadian Rhythm Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D011499:Protein Processing, Post-Translational
chemical_list: D056925:Circadian Rhythm Signaling Peptides and Proteins