title: High Serum Adiponectin Level Is a Risk Factor for Anemia in Japanese Men: A Prospective Observational Study of 1,029 Japanese Subjects.
abstract: Erythroid abnormalities including anemia and polycythemia are often observed in the general clinical setting. Because recent studies reported that adiponectin negatively affects hematopoiesis, we performed a prospective observational study to assess the relationship between anemia and adiponectin, as well as other parameters, in 1029 Japanese subjects (477 men and 552 women) 40 years of age and older. Body measurements, blood tests, and nutrition intake studies were performed at baseline, and 5 to 7 years later (follow-up). Hemoglobin (Hb) and hematocrit (Hct) levels in men with high serum adiponectin levels were lower at follow-up than at baseline. Multiple regression analysis showed that age, body mass index, adiponectin, and glutamic-pyruvic transaminase were significantly associated with erythroid-related variables (red blood cells, Hb, and Hct) in both men and women (P <0.05). In a logistic regression analysis, adiponectin, fasting blood glucose, and β-natriuretic peptide were significant risk factors for anemia in men, and blood urea nitrogen and amylase were significant risk factors in women. Physical features and nutrient intake were not risk factors for anemia. Our study demonstrates, both clinically and epidemiologically, that a high serum adiponectin level decreases the amounts of erythroid-related variables and is a risk factor for anemia in Japanese men.
authors.affiliation: Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University School of Medicine, Yamagata City, Yamagata, Japan.
authors.forename: Kei
authors.initials: K
authors.lastname: Kohno
authors.affiliation: Cancer Prevention and Control Division, Kanagawa Cancer Center Research Institute, Yokohama City, Kanagawa, Japan.
authors.forename: Hiroto
authors.initials: H
authors.lastname: Narimatsu
authors.affiliation: Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University School of Medicine, Yamagata City, Yamagata, Japan.
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Shiono
authors.affiliation: Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University School of Medicine, Yamagata City, Yamagata, Japan.
authors.forename: Ikuko
authors.initials: I
authors.lastname: Suzuki
authors.affiliation: Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University School of Medicine, Yamagata City, Yamagata, Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Kato
authors.affiliation: Department of Public Health, Yamagata University Graduate School of Medicine, Yamagata City, Yamagata, Japan.
authors.forename: Ri
authors.initials: R
authors.lastname: Sho
authors.affiliation: Department of Public Health, Yamagata University Graduate School of Medicine, Yamagata City, Yamagata, Japan.
authors.forename: Katsumi
authors.initials: K
authors.lastname: Otani
authors.affiliation: Department of Hematology and Cell Therapy, Yamagata University School of Medicine, Yamagata City, Yamagata, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Ishizawa
authors.affiliation: Department of Ophthalmology and Visual Sciences, Yamagata University School of Medicine, Yamagata City, Yamagata, Japan.
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Yamashita
authors.affiliation: First Department of Internal Medicine, Yamagata University School of Medicine, Yamagata City, Yamagata, Japan.
authors.forename: Isao
authors.initials: I
authors.lastname: Kubota
authors.affiliation: Second Department of Internal Medicine, Yamagata University School of Medicine, Yamagata City, Yamagata, Japan.
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Ueno
authors.affiliation: Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University School of Medicine, Yamagata City, Yamagata, Japan.
authors.forename: Takeo
authors.initials: T
authors.lastname: Kato
authors.affiliation: Department of Public Health, Yamagata University Graduate School of Medicine, Yamagata City, Yamagata, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Fukao
authors.affiliation: Department of Neurosurgery, Yamagata University School of Medicine, Yamagata City, Yamagata, Japan.
authors.forename: Takamasa
authors.initials: T
authors.lastname: Kayama
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000410:Alanine Transaminase / Q000378:metabolism; D000681:Amylases / Q000378:metabolism; D000740:Anemia / Q000097:blood* / Q000209:etiology* / Q000378:metabolism; D044466:Asian People; D001786:Blood Glucose / Q000378:metabolism; D001806:Blood Urea Nitrogen; D005260:Female; D005500:Follow-Up Studies; D006400:Hematocrit / Q000379:methods; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011446:Prospective Studies; D012044:Regression Analysis; D012307:Risk Factors
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D006454:Hemoglobins; D000410:Alanine Transaminase; D000681:Amylases