title: Regulatory Circuits and Bi-directional Signaling between Stem Cells and Their Progeny.
abstract: Feedback signals from daughter cells to stem cells are well studied and known to provide important feedback cues. Emerging evidence shows that stem cells also send feedforward signals to their progeny. Complex circuits involving both negative and positive feedback and feedforward signals likely contribute to robust tissue maintenance and regeneration.
authors.affiliation: Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
authors.forename: Purushothama Rao
authors.initials: PR
authors.lastname: Tata
authors.affiliation: Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Massachusetts General Hospital for Children, Pediatric Pulmonary Medicine, Boston, MA 02114, USA; Division of Otology and Laryngology, Massachusetts Eye and Ear, Boston, MA 02114, USA. Electronic address: jrajagopal@mgh.harvard.edu.
authors.forename: Jayaraj
authors.initials: J
authors.lastname: Rajagopal
mesh_terms: D000818:Animals; D019898:Autocrine Communication; D019070:Cell Lineage; D025461:Feedback, Physiological; D006801:Humans; D008954:Models, Biological; D015398:Signal Transduction; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism*