title: Bayesian reversible-jump for epistasis analysis in genomic studies.
abstract: The large amount of data used in genomic analysis has allowed geneticists to achieve some understanding of the genetic architecture of complex traits. Although the information gathered by molecular markers has permitted gains in predictive accuracy and gene discovery, epistatic effects have been ignored based on exhaustive searches requesting estimates of its effects on the whole genome. In this work, we propose the reversible-jump technique to estimate epistasis in the genome without drastically altering the model dimension. To this end, we used a real maize dataset based on 256 F2:3progenies plus a simulation data set based on 300 F2individuals. In the simulation scenario, six QTL presenting main effects (additive and dominance) were combined with seven other epistatic effects totaling 13 QTL controlling the trait.
  
  
  
  Our model explored 18,624 candidate epistases, but even in this vast space, only one spurious interaction was found. The three epistases selected by our model, named here as 18x26, 56x68 and 59x93, were very close to simulated ones (19x25, 54x72, 59x91 and 59x94). In the real dataset, we estimate 33,024 epistatic effects, and several minor epistatic combinations were found to explain a significant proportion of the genetic variance. The broad participation of epistasis in the real dataset may indicate the presence of pervasive epistasis acting on maize grain yield.
  
  
  
  The power of selecting true epistasis in thousands of possible combinations suggests the attractiveness of our model to handle genomic data.
authors.affiliation: Department of Statistics- Federal University of Lavras, Lavras, MG, CP 3037, Brazil. marciobalestre@dex.ufla.br.
authors.forename: Marcio
authors.initials: M
authors.lastname: Balestre
authors.affiliation: Departmento de Genética, Escola de Agricultura Luiz de Queiroz, Universidade de São Paulo, (ESALQ-USP) Piracicaba, São Paulo, 13400-970 CP 83, Brazil.
authors.forename: Claudio Lopes
authors.initials: CL
authors.lastname: de Souza
mesh_terms: D001499:Bayes Theorem; D004843:Epistasis, Genetic; D008040:Genetic Linkage; D023281:Genomics / Q000379:methods; D008126:Lod Score; D008957:Models, Genetic; D040641:Quantitative Trait Loci; D019655:Quantitative Trait, Heritable; D012641:Selection, Genetic; D003313:Zea mays / Q000235:genetics
keywords: Bayesian analysis; Genome-wide studies; Maize; QTL