title: Fate and ecotoxicological impact of new generation herbicides from the triketone family: An overview to assess the environmental risks.
abstract: Triketones, derived chemically from a natural phytotoxin (leptospermone), are a good example of allelochemicals as lead molecules for the development of new herbicides. Targeting a new and key enzyme involved in carotenoid biosynthesis, these latest-generation herbicides (sulcotrione, mesotrione and tembotrione) were designed to be eco-friendly and commercialized fifteen-twenty years ago. The mechanisms controlling their fate in different ecological niches as well as their toxicity and impact on different organisms or ecosystems are still under investigation. This review combines an overview of the results published in the literature on β-triketones and more specifically, on the commercially-available herbicides and includes new results obtained in our interdisciplinary study aiming to understand all the processes involved (i) in their transfer from the soil to the connected aquatic compartments, (ii) in their transformation by photochemical and biological mechanisms but also to evaluate (iii) the impacts of the parent molecules and their transformation products on various target and non-target organisms (aquatic microorganisms, plants, soil microbial communities). Analysis of all the data on the fate and impact of these molecules, used pure, as formulation or in cocktails, give an overall guide for the assessment of their environmental risks.
authors.affiliation: Clermont Université, Université Blaise Pascal, Institut de Chimie de Clermont-Ferrand, BP 10448, 63000 Clermont-Ferrand, France; CNRS, UMR 6296, ICCF, TSA 60026, CS 60026, 63178 Aubière Cedex, France.
authors.forename: E
authors.initials: E
authors.lastname: Dumas
authors.affiliation: Clermont Université, Université Blaise Pascal-Université d'Auvergne, Laboratoire Microorganismes: Génome et Environnement, BP 10448, 63000 Clermont Ferrand, France; CNRS, UMR 6023, LMGE, TSA 60026, CS 60026, 63178 Aubière Cedex, France.
authors.forename: M
authors.initials: M
authors.lastname: Giraudo
authors.affiliation: Clermont Université, Université Blaise Pascal, Physique et Physiologie Intégratives de l'Arbre Fruitier et Forestier, 63000 Clermont-Ferrand, France; INRA, UMR PIAF 547, TSA 60026, CS 60026, 63178 Aubière Cedex, France.
authors.forename: E
authors.initials: E
authors.lastname: Goujon
authors.affiliation: Clermont Université, Université Blaise Pascal, Institut de Chimie de Clermont-Ferrand, BP 10448, 63000 Clermont-Ferrand, France; CNRS, UMR 6296, ICCF, TSA 60026, CS 60026, 63178 Aubière Cedex, France.
authors.forename: M
authors.initials: M
authors.lastname: Halma
authors.affiliation: Clermont Université, Université Blaise Pascal, Institut de Chimie de Clermont-Ferrand, BP 10448, 63000 Clermont-Ferrand, France; CNRS, UMR 6296, ICCF, TSA 60026, CS 60026, 63178 Aubière Cedex, France.
authors.forename: E
authors.initials: E
authors.lastname: Knhili
authors.affiliation: Clermont Université, Université Blaise Pascal, Institut de Chimie de Clermont-Ferrand, BP 10448, 63000 Clermont-Ferrand, France; CNRS, UMR 6296, ICCF, TSA 60026, CS 60026, 63178 Aubière Cedex, France; Clermont Université, Université Blaise Pascal-Université d'Auvergne, Laboratoire Microorganismes: Génome et Environnement, BP 10448, 63000 Clermont Ferrand, France; CNRS, UMR 6023, LMGE, TSA 60026, CS 60026, 63178 Aubière Cedex, France.
authors.forename: M
authors.initials: M
authors.lastname: Stauffert
authors.affiliation: Clermont Université, Université Blaise Pascal-Université d'Auvergne, Laboratoire Microorganismes: Génome et Environnement, BP 10448, 63000 Clermont Ferrand, France; CNRS, UMR 6023, LMGE, TSA 60026, CS 60026, 63178 Aubière Cedex, France.
authors.forename: I
authors.initials: I
authors.lastname: Batisson
authors.affiliation: Clermont Université, Université Blaise Pascal, Institut de Chimie de Clermont-Ferrand, BP 10448, 63000 Clermont-Ferrand, France; CNRS, UMR 6296, ICCF, TSA 60026, CS 60026, 63178 Aubière Cedex, France. Electronic address: Pascale.Besse@univ-bpclermont.fr.
authors.forename: P
authors.initials: P
authors.lastname: Besse-Hoggan
authors.affiliation: Clermont Université, Université Blaise Pascal-Université d'Auvergne, Laboratoire Microorganismes: Génome et Environnement, BP 10448, 63000 Clermont Ferrand, France; CNRS, UMR 6023, LMGE, TSA 60026, CS 60026, 63178 Aubière Cedex, France.
authors.forename: J
authors.initials: J
authors.lastname: Bohatier
authors.affiliation: Clermont Université, Université Blaise Pascal-Université d'Auvergne, Laboratoire Microorganismes: Génome et Environnement, BP 10448, 63000 Clermont Ferrand, France; CNRS, UMR 6023, LMGE, TSA 60026, CS 60026, 63178 Aubière Cedex, France.
authors.forename: P
authors.initials: P
authors.lastname: Bouchard
authors.affiliation: Clermont Université, Université Blaise Pascal, Laboratoire Magmas et Volcans, BP 10448, 63000 Clermont-Ferrand, France; CNRS, UMR 6524, LMV, TSA 60026, CS 60026, 63178 Aubière Cedex, France.
authors.forename: H
authors.initials: H
authors.lastname: Celle-Jeanton
authors.affiliation: Clermont Université, Université Blaise Pascal, Institut de Chimie de Clermont-Ferrand, BP 10448, 63000 Clermont-Ferrand, France; CNRS, UMR 6296, ICCF, TSA 60026, CS 60026, 63178 Aubière Cedex, France.
authors.forename: M
authors.initials: M
authors.lastname: Costa Gomes
authors.affiliation: Clermont Université, Université Blaise Pascal-Université d'Auvergne, Laboratoire Microorganismes: Génome et Environnement, BP 10448, 63000 Clermont Ferrand, France; CNRS, UMR 6023, LMGE, TSA 60026, CS 60026, 63178 Aubière Cedex, France.
authors.forename: F
authors.initials: F
authors.lastname: Delbac
authors.affiliation: Clermont Université, Université Blaise Pascal, Institut de Chimie de Clermont-Ferrand, BP 10448, 63000 Clermont-Ferrand, France; CNRS, UMR 6296, ICCF, TSA 60026, CS 60026, 63178 Aubière Cedex, France.
authors.forename: C
authors.initials: C
authors.lastname: Forano
authors.affiliation: Clermont Université, Université Blaise Pascal, Physique et Physiologie Intégratives de l'Arbre Fruitier et Forestier, 63000 Clermont-Ferrand, France; INRA, UMR PIAF 547, TSA 60026, CS 60026, 63178 Aubière Cedex, France.
authors.forename: P
authors.initials: P
authors.lastname: Goupil
authors.affiliation: INRA, UMR 1095 Génétique, Diversité et Ecophysiologie des Céréales, 5 chemin de Beaulieu, 63039 Clermont-Ferrand, France; VetAgro Sup, 89 avenue de l'Europe, BP 35, 63370 Lempdes, France; UMR Génétique Diversité et Ecophysiologie des Céréales, INRA-UBP, UMR 1095, 63000 Clermont-Ferrand, France.
authors.forename: N
authors.initials: N
authors.lastname: Guix
authors.affiliation: Clermont Université, Université Blaise Pascal, Institut de Chimie de Clermont-Ferrand, BP 10448, 63000 Clermont-Ferrand, France; CNRS, UMR 6296, ICCF, TSA 60026, CS 60026, 63178 Aubière Cedex, France.
authors.forename: P
authors.initials: P
authors.lastname: Husson
authors.affiliation: Clermont Université, Université Blaise Pascal, Physique et Physiologie Intégratives de l'Arbre Fruitier et Forestier, 63000 Clermont-Ferrand, France; INRA, UMR PIAF 547, TSA 60026, CS 60026, 63178 Aubière Cedex, France.
authors.forename: G
authors.initials: G
authors.lastname: Ledoigt
authors.affiliation: Clermont Université, Université Blaise Pascal-Université d'Auvergne, Laboratoire Microorganismes: Génome et Environnement, BP 10448, 63000 Clermont Ferrand, France; CNRS, UMR 6023, LMGE, TSA 60026, CS 60026, 63178 Aubière Cedex, France.
authors.forename: C
authors.initials: C
authors.lastname: Mallet
authors.affiliation: Clermont Université, Université Blaise Pascal, Institut de Chimie de Clermont-Ferrand, BP 10448, 63000 Clermont-Ferrand, France; CNRS, UMR 6296, ICCF, TSA 60026, CS 60026, 63178 Aubière Cedex, France.
authors.forename: C
authors.initials: C
authors.lastname: Mousty
authors.affiliation: Clermont Université, Université Blaise Pascal, Institut de Chimie de Clermont-Ferrand, BP 10448, 63000 Clermont-Ferrand, France; CNRS, UMR 6296, ICCF, TSA 60026, CS 60026, 63178 Aubière Cedex, France.
authors.forename: V
authors.initials: V
authors.lastname: Prévot
authors.affiliation: Clermont Université, Université Blaise Pascal, Institut de Chimie de Clermont-Ferrand, BP 10448, 63000 Clermont-Ferrand, France; CNRS, UMR 6296, ICCF, TSA 60026, CS 60026, 63178 Aubière Cedex, France.
authors.forename: C
authors.initials: C
authors.lastname: Richard
authors.affiliation: Clermont Université, Université Blaise Pascal, Institut de Chimie de Clermont-Ferrand, BP 10448, 63000 Clermont-Ferrand, France; CNRS, UMR 6296, ICCF, TSA 60026, CS 60026, 63178 Aubière Cedex, France.
authors.forename: S
authors.initials: S
authors.lastname: Sarraute
mesh_terms: D003512:Cyclohexanones / Q000032:analysis; D017753:Ecosystem; D054750:Ecotoxicology; D004777:Environment; D006540:Herbicides / Q000032:analysis* / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007659:Ketones / Q000032:analysis* / Q000737:chemistry*; D008698:Mesylates / Q000032:analysis; D010777:Photochemistry; D010944:Plants / Q000187:drug effects; D018570:Risk Assessment; D012987:Soil; D012988:Soil Microbiology; D013450:Sulfones / Q000032:analysis; D013696:Temperature; D014867:Water; D014874:Water Pollutants, Chemical / Q000737:chemistry
chemical_list: D003512:Cyclohexanones; D006540:Herbicides; D007659:Ketones; D008698:Mesylates; D012987:Soil; D013450:Sulfones; D014874:Water Pollutants, Chemical; D014867:Water; C432907:mesotrione; C079906:sulcotrione; C585552:tembotrione
keywords: Degradation products; Formulation; Mesotrione; Sulcotrione; Tembotrione