title: Short Communication: Lack of Effect of Maraviroc Intensification on Blood and Gut Reservoir.
abstract: We show that intensification of treatment with maraviroc in patients chronically infected with HIV-1 receiving successful long-term antiretroviral therapy was not associated with improvements in HIV-related morbidity, HIV reservoir, microbial translocation, immune activation, or immune exhaustion in either gut or peripheral blood. The measurement of reservoir in both gut and blood longitudinally contributes to a paucity of data in the area.
authors.affiliation: 1 Department of Genitourinary Medicine, Guys and St. Thomas' NHS Foundation Trust , London, United Kingdom .
authors.forename: Juan
authors.initials: J
authors.lastname: Tiraboschi
authors.affiliation: 1 Department of Genitourinary Medicine, Guys and St. Thomas' NHS Foundation Trust , London, United Kingdom .
authors.forename: Shuvra
authors.initials: S
authors.lastname: Ray
authors.affiliation: 1 Department of Genitourinary Medicine, Guys and St. Thomas' NHS Foundation Trust , London, United Kingdom .
authors.forename: Kemal
authors.initials: K
authors.lastname: Patel
authors.affiliation: 2 University of Oxford , Oxford, United Kingdom .
authors.forename: Matt
authors.initials: M
authors.lastname: Pace
authors.affiliation: 2 University of Oxford , Oxford, United Kingdom .
authors.forename: Prabhjeet
authors.initials: P
authors.lastname: Phalora
authors.affiliation: 2 University of Oxford , Oxford, United Kingdom .
authors.forename: Nicola
authors.initials: N
authors.lastname: Robinson
authors.affiliation: 2 University of Oxford , Oxford, United Kingdom .
authors.forename: Emily
authors.initials: E
authors.lastname: Hopkins
authors.affiliation: 2 University of Oxford , Oxford, United Kingdom .
authors.forename: Jodi
authors.initials: J
authors.lastname: Meyerowitz
authors.affiliation: 3 Department of Infectious Diseases, Kings College London , London, United Kingdom .
authors.forename: Yanzhong
authors.initials: Y
authors.lastname: Wang
authors.affiliation: 1 Department of Genitourinary Medicine, Guys and St. Thomas' NHS Foundation Trust , London, United Kingdom .
authors.forename: Olubanke
authors.initials: O
authors.lastname: Davies
authors.affiliation: 3 Department of Infectious Diseases, Kings College London , London, United Kingdom .
authors.forename: Christine
authors.initials: C
authors.lastname: Mant
authors.affiliation: 3 Department of Infectious Diseases, Kings College London , London, United Kingdom .
authors.forename: John
authors.initials: J
authors.lastname: Cason
authors.affiliation: 4 Imperial College London , London, United Kingdom .
authors.forename: Steve
authors.initials: S
authors.lastname: Kaye
authors.affiliation: 1 Department of Genitourinary Medicine, Guys and St. Thomas' NHS Foundation Trust , London, United Kingdom .
authors.forename: Jeremy
authors.initials: J
authors.lastname: Sanderson
authors.affiliation: 4 Imperial College London , London, United Kingdom .
authors.forename: Sarah
authors.initials: S
authors.lastname: Fidler
authors.affiliation: 2 University of Oxford , Oxford, United Kingdom .
authors.forename: Paul
authors.initials: P
authors.lastname: Klenerman
authors.affiliation: 2 University of Oxford , Oxford, United Kingdom .|5 Oxford National Institute of Health , Oxford, United Kingdom .|6 Oxford National Institute of Health Research Biomedical Research Centre , Oxford, United Kingdom .
authors.forename: John
authors.initials: J
authors.lastname: Frater
authors.affiliation: 1 Department of Genitourinary Medicine, Guys and St. Thomas' NHS Foundation Trust , London, United Kingdom .
authors.forename: Julie
authors.initials: J
authors.lastname: Fox
mesh_terms: D001769:Blood / Q000821:virology*; D065100:CCR5 Receptor Antagonists / Q000008:administration & dosage*; D003510:Cyclohexanes / Q000008:administration & dosage*; D041981:Gastrointestinal Tract / Q000821:virology*; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology*; D006801:Humans; D008297:Male; D000077592:Maraviroc; D008875:Middle Aged; D010865:Pilot Projects; D011446:Prospective Studies; D016896:Treatment Outcome; D014230:Triazoles / Q000008:administration & dosage*
chemical_list: D065100:CCR5 Receptor Antagonists; D003510:Cyclohexanes; D014230:Triazoles; D000077592:Maraviroc
keywords: HIV; antiretroviral therapy; immune activation; microbial translocation; viral reservoirs