title: Changes in Respiratory Function during Treatment with Combination of Analgesic Substances Trimeperidine and Dexmedetomidine.
abstract: The effects of analgesic substances trimeperidine and dexmedetomidine and their combinations in different proportions (0.75:0.25, 0.5:0.5, 0.25:0.75 of the medium effective doses of each substance) on respiratory function was studied in experiments on rats. Administration of substances in 1 ED50by analgesic effect (corresponded to medium therapeutic dose of trimeperidine in humans) was characterized by significantly longer suppression of respiration over 90 min in comparison with combined treatment with these substances. Administration of the substances in a dose of 8 ED50by analgesic effect (corresponded to daily therapeutic dose) over 60 min was followed by more than 3-fold reduction in respiration frequency and respiratory minute volume, more pronounced in animals receiving trimeperidine. Combined administration of these drugs in the specifi ed dose induced less pronounced suppression of respiration and combined administration of trimeperidine and dexmedetomidine in proportion of 0.75:0.25 signifi cantly reduced the period of restoration of respiratory parameters in comparison with animals receiving single substances.
authors.affiliation: State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation, St. Petersburg, Russia.
authors.forename: M A
authors.initials: MA
authors.lastname: Yudin
authors.affiliation: State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation, St. Petersburg, Russia. ng@vengerovich.ru.
authors.forename: N G
authors.initials: NG
authors.lastname: Vengerovich
authors.affiliation: State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation, St. Petersburg, Russia.
authors.forename: G S
authors.initials: GS
authors.lastname: Sagalov
authors.affiliation: Innovative Pharmaceutical Company Silver Farm, St. Petersburg, Russia.
authors.forename: M S
authors.initials: MS
authors.lastname: Vahvijanen
authors.affiliation: State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation, St. Petersburg, Russia.
authors.forename: V N
authors.initials: VN
authors.lastname: Bykov
authors.affiliation: State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation, St. Petersburg, Russia.
authors.forename: S V
authors.initials: SV
authors.lastname: Chepur
mesh_terms: D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D021461:Animals, Outbred Strains; D020927:Dexmedetomidine / Q000494:pharmacology*; D004334:Drug Administration Schedule; D004338:Drug Combinations; D054796:Drug Dosage Calculations; D008297:Male; D011396:Promedol / Q000494:pharmacology*; D051381:Rats; D012119:Respiration / Q000187:drug effects*; D012129:Respiratory Function Tests
chemical_list: D018712:Analgesics, Non-Narcotic; D000701:Analgesics, Opioid; D004338:Drug Combinations; D011396:Promedol; D020927:Dexmedetomidine
keywords: combined treatment; dexmedetomidine; respiratory function; trimeperidine