title: Metal-Organic Framework as a Protective Coating for Biodiagnostic Chips.
abstract: Zeolitic imidazolate framework-8 (ZIF-8) grown around antibodies anchored to plasmonic nanostructures serves as a protective layer to preserve the biorecognition ability of antibodies stored at room and elevated temperatures for several days. The biofunctionality of the ZIF-8-protected biochip can be restored by a simple water-rinsing step, making it highly convenient for use in point-of-care and resource-limited settings.
authors.affiliation: Department of Mechanical Engineering and Materials Science, Institute of Materials Science and Engineering, Washington University in St. Louis, Saint Louis, MO, 63130, USA.
authors.forename: Congzhou
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Mechanical Engineering and Materials Science, Institute of Materials Science and Engineering, Washington University in St. Louis, Saint Louis, MO, 63130, USA.
authors.forename: Sirimuvva
authors.initials: S
authors.lastname: Tadepalli
authors.affiliation: Department of Mechanical Engineering and Materials Science, Institute of Materials Science and Engineering, Washington University in St. Louis, Saint Louis, MO, 63130, USA.
authors.forename: Jingyi
authors.initials: J
authors.lastname: Luan
authors.affiliation: Department of Mechanical Engineering and Materials Science, Institute of Materials Science and Engineering, Washington University in St. Louis, Saint Louis, MO, 63130, USA.
authors.forename: Keng-Ku
authors.initials: KK
authors.lastname: Liu
authors.affiliation: Department of Anesthesiology, Washington University in St. Louis, St. Louis, MO, 63110, USA.|Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, 63110, USA.|Department of Biochemistry and Molecular Biophysics, Washington University in St. Louis, St. Louis, MO, 63110, USA.|The Center for Clinical Pharmacology, St. Louis College of Pharmacy and Washington University School of Medicine, St. Louis, MO, 63110, USA.
authors.forename: Jeremiah J
authors.initials: JJ
authors.lastname: Morrissey
authors.affiliation: Department of Anesthesiology, Washington University in St. Louis, St. Louis, MO, 63110, USA.|Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, 63110, USA.|Department of Biochemistry and Molecular Biophysics, Washington University in St. Louis, St. Louis, MO, 63110, USA.|The Center for Clinical Pharmacology, St. Louis College of Pharmacy and Washington University School of Medicine, St. Louis, MO, 63110, USA.
authors.forename: Evan D
authors.initials: ED
authors.lastname: Kharasch
authors.affiliation: 711th Human Performance Wing, Wright-Patterson, Air Force Base, Dayton, OH, 45433, USA.
authors.forename: Rajesh R
authors.initials: RR
authors.lastname: Naik
authors.affiliation: Department of Mechanical Engineering and Materials Science, Institute of Materials Science and Engineering, Washington University in St. Louis, Saint Louis, MO, 63130, USA.
authors.forename: Srikanth
authors.initials: S
authors.lastname: Singamaneni
mesh_terms: D007093:Imidazoles; D000073396:Metal-Organic Frameworks / Q000737:chemistry*; D017641:Zeolites
chemical_list: D007093:Imidazoles; D000073396:Metal-Organic Frameworks; D017641:Zeolites
keywords: ZIF-8 preservation; antibody; biodiagnostics; metal-organic framework; plasmonic biosensors