title: Expression and Processing of Amyloid Precursor Protein in Vascular Endothelium.
abstract: Amyloid precursor protein (APP) is evolutionary conserved protein expressed in endothelial cells of cerebral and peripheral arteries. In this review, we discuss mechanisms responsible for expression and proteolytic cleavage of APP in endothelial cells. We focus on physiological and pathological implications of APP expression in vascular endothelium.
authors.affiliation: Departments of Anesthesiology and Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, Minnesota.
authors.forename: Livius V
authors.initials: LV
authors.lastname: d'Uscio
authors.affiliation: Departments of Anesthesiology and Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, Minnesota.
authors.forename: Tongrong
authors.initials: T
authors.lastname: He
authors.affiliation: Departments of Anesthesiology and Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, Minnesota.
authors.forename: Zvonimir S
authors.initials: ZS
authors.lastname: Katusic
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism; D016564:Amyloid beta-Protein Precursor / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D050197:Atherosclerosis / Q000378:metabolism; D001921:Brain / Q000098:blood supply* / Q000378:metabolism*; D002319:Cardiovascular System / Q000378:metabolism; D004730:Endothelium, Vascular / Q000378:metabolism*; D011464:Epoprostenol / Q000378:metabolism; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D009389:Neovascularization, Pathologic; D018919:Neovascularization, Physiologic; D009609:Nitrous Oxide / Q000378:metabolism; D059748:Proteolysis
chemical_list: D016564:Amyloid beta-Protein Precursor; D011464:Epoprostenol; D009609:Nitrous Oxide