title: Expression of Glut-1 and HK-II in Pancreatic Cancer and Their Impact on Prognosis and FDG Accumulation.
abstract: OBJECTIVE
  The purpose of this article is to analyze the expression of Glut-1 and HK-II, the association between their expression and18F-FDG accumulation in pancreatic cancer.
  
  
  METHODS
  Fifty patients with histologically proven pancreatic cancer were included in this preliminary study, all of whom received18F-FDG PET/CT performance before surgery. Immunohistochemical staining of tumor tissue and adjacent normal tissue was performed for Glut-1 and HK-II. By combining proportions and intensity of immunochemical staining, we obtained the modified immunohistological scores for Glut-1 and HK-II respectively. The relationship between expression of Glut-1, HK-II and series of parameters was analyzed, i.e. clinicopathological characteristics, prognosis of patients and SUVmaxof PET-CT.
  
  
  RESULTS
  Compared with normal tissue, the Glut-1 and HK-II expression in pancreatic cancer tissue was significantly increased (P<.001). There was no correlation between expression of Glut-1, HK-II and age, gender, tumor size, tumor location, tumor histological type, tumor differentiation, the nerve infiltration, vascular invasion, local infiltration, lymph node metastasis or tumor staging in pancreatic cancer (P>.05). During the follow-up period, the survival curves of low Glut-1 group and high Glut-1 group were statistically different (P=.049). Multivariate analysis (Cox regression) revealed that Glut-1 expression was not associated with mortality (P>.05). No statistical difference was found in the survival curves of negative HK-II group and positive HK-II group (P=.545). There was no correlation between18F-FDG uptake and expression of Glut-1 and HK-II(P>.05).
  
  
  CONCLUSIONS
  The Glut-1 and HK-II expression in pancreatic cancer tissue was significantly increased. There was no correlation between expression of Glut-1, HK-II and clinicopathological characteristics, prognosis and18F-FDG uptake.
authors.affiliation: Department of Gastroenterology, Huashan Hospital, Fudan University, 12 Wulumuqi Middle Road, Shanghai 200040, China. Electronic address: yhjlqelfe@126.com.
authors.forename: Hai-Jing
authors.initials: HJ
authors.lastname: Yang
authors.affiliation: Department of Gastroenterology, Huashan Hospital, Fudan University, 12 Wulumuqi Middle Road, Shanghai 200040, China. Electronic address: wj.xu1204@gmail.com.
authors.forename: Wei-Jia
authors.initials: WJ
authors.lastname: Xu
authors.affiliation: PET Center of Huashan Hospital, Fudan University, 518 Wuzhong East Road, Shanghai 200235, China.
authors.forename: Yi-Hui
authors.initials: YH
authors.lastname: Guan
authors.affiliation: PET Center of Huashan Hospital, Fudan University, 518 Wuzhong East Road, Shanghai 200235, China.
authors.forename: Hui-Wei
authors.initials: HW
authors.lastname: Zhang
authors.affiliation: Department of Gastroenterology, Huashan Hospital, Fudan University, 12 Wulumuqi Middle Road, Shanghai 200040, China.
authors.forename: Wei-Qun
authors.initials: WQ
authors.lastname: Ding
authors.affiliation: Department of Gastroenterology, Huashan Hospital, Fudan University, 12 Wulumuqi Middle Road, Shanghai 200040, China.
authors.forename: Lan
authors.initials: L
authors.lastname: Rong
authors.affiliation: Department of Gastroenterology, Huashan Hospital, Fudan University, 12 Wulumuqi Middle Road, Shanghai 200040, China.
authors.forename: Zhi-Bing
authors.initials: ZB
authors.lastname: Qiu
authors.affiliation: Department of Gastroenterology, Huashan Hospital, Fudan University, 12 Wulumuqi Middle Road, Shanghai 200040, China. Electronic address: zhongniping@163.com.
authors.forename: Liang
authors.initials: L
authors.lastname: Zhong