title: Effect of aerobic exercise intervention on markers of insulin resistance in breast cancer women.
abstract: Insulin may affect breast cancer (BC) risk and prognosis. Exercise reduces insulin in obese BC survivors. We designed a randomised controlled trial to test the effect of an aerobic exercise intervention (AEI) on insulin parameters and body composition in non-obese BC women without insulin resistance. Thirty-eight BC women were randomised into an intervention group (IG = 18) or control group (CG = 20). IG participated in a structured AEI for 3 months, while CG received only the Word Cancer Research Fund/American Institute Cancer Research (WCRF/AICR) recommendation to be physically active. Fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR) index, metabolic parameters and body composition were collected at baseline and after the AEI. IG reduced insulin and HOMA-IR index by 15% and 14%, while CG increased these parameters (+12% and +16%). Insulin changed differently over time in the two randomised groups (pinteraction= .04). The between-group differences in the change of insulin (IG = -1.2 μU/ml versus CG = +0.8 μU/ml) and HOMA-IR index (IG = -0.26 versus CG = +0.25) were respectively significant (p = .04) and non-significant (p = .06). IG significantly improved lower limb muscle mass in comparison with CG (p = .03). A structured AEI may improve insulin, HOMA-IR index and body composition in non-obese BC survivors without insulin resistance.
authors.affiliation: Department of Biomedical Sciences for Health, University of Milan, Milan, Italy.|Department of Predictive & Preventive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Bruno
authors.affiliation: Department of Biomedical Sciences for Health, University of Milan, Milan, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Roveda
authors.affiliation: IRCCS Istituto Ortopedico Galeazzi, Milan, Italy.
authors.forename: J
authors.initials: J
authors.lastname: Vitale
authors.affiliation: Department of Biomedical Sciences for Health, University of Milan, Milan, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Montaruli
authors.affiliation: Department of Predictive & Preventive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Berrino
authors.affiliation: Department of Predictive & Preventive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Villarini
authors.affiliation: Department of Predictive & Preventive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Venturelli
authors.affiliation: Department of Predictive & Preventive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Gargano
authors.affiliation: Department of Biomedical Sciences for Health, University of Milan, Milan, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Galasso
authors.affiliation: Research Centre of Metabolism, IRCCS Policlinico San Donato Milanese, Milan, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Caumo
authors.affiliation: Department of Biomedical Sciences for Health, University of Milan, Milan, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Carandente
authors.affiliation: Department of Predictive & Preventive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Pasanisi
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D015415:Biomarkers / Q000378:metabolism*; D001823:Body Composition / Q000502:physiology; D001943:Breast Neoplasms / Q000097:blood / Q000503:physiopathology; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance / Q000502:physiology*; D008875:Middle Aged
chemical_list: D015415:Biomarkers; D007328:Insulin
keywords: HOMA-IR index; aerobic exercise; body composition; breast cancer; insulin