title: Primary cilia: a link between hormone signalling and endocrine-related cancers?
abstract: Primary cilia are sensory organelles that play a role as signalling hubs. Disruption of primary cilia structure and function is increasingly recognised in a range of cancers, with a growing body of evidence suggesting that ciliary disruption contributes to tumourigenesis. This review considers the role of primary cilia in the pathogenesis of endocrine-related cancers.
authors.affiliation: Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, U.K.
authors.forename: Samuel M
authors.initials: SM
authors.lastname: O'Toole
authors.affiliation: Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, U.K.
authors.forename: J Paul
authors.initials: JP
authors.lastname: Chapple
mesh_terms: D000818:Animals; D054468:Axoneme / Q000378:metabolism; D064652:Basal Bodies / Q000378:metabolism; D002923:Cilia / Q000378:metabolism* / Q000473:pathology; D004701:Endocrine Gland Neoplasms / Q000378:metabolism / Q000473:pathology; D006728:Hormones / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology; D015398:Signal Transduction
chemical_list: D006728:Hormones
keywords: Von Hippel–Lindau; breast cancers; cilia; endocrine cancer; ovarian cancer; prostate cancer