title: A dataset of multiresolution functional brain parcellations in an elderly population with no or mild cognitive impairment.
abstract: We present group eight resolutions of brain parcellations for clusters generated from resting-state functional magnetic resonance images for 99 cognitively normal elderly persons and 129 patients with mild cognitive impairment, pooled from four independent datasets. This dataset was generated as part of the following study:Common Effects of Amnestic Mild Cognitive Impairment on Resting-State Connectivity Across Four Independent Studies(Tam et al., 2015) [1]. The brain parcellations have been registered to both symmetric and asymmetric MNI brain templates and generated using a method called bootstrap analysis of stable clusters (BASC) (Bellec et al., 2010) [2]. We present two variants of these parcellations. One variant contains bihemisphereic parcels (4, 6, 12, 22, 33, 65, 111, and 208 total parcels across eight resolutions). The second variant contains spatially connected regions of interest (ROIs) that span only one hemisphere (10, 17, 30, 51, 77, 199, and 322 total ROIs across eight resolutions). We also present maps illustrating functional connectivity differences between patients and controls for four regions of interest (striatum, dorsal prefrontal cortex, middle temporal lobe, and medial frontal cortex). The brain parcels and associated statistical maps have been publicly released as 3D volumes, available in .mnc and .nii file formats on figshare and on Neurovault. Finally, the code used to generate this dataset is available on Github.
authors.affiliation: McGill University, Montreal, QC, Canada; Douglas Mental Health University Institute, Research Centre, Montreal, QC, Canada; Centre de recherche de l'institut universitaire de gériatrie de Montréal, QC, Canada.
authors.forename: Angela
authors.initials: A
authors.lastname: Tam
authors.affiliation: Centre de recherche de l'institut universitaire de gériatrie de Montréal, QC, Canada; Université de Montréal, QC, Canada.
authors.forename: Christian
authors.initials: C
authors.lastname: Dansereau
authors.affiliation: Centre de recherche de l'institut universitaire de gériatrie de Montréal, QC, Canada; Université de Montréal, QC, Canada.
authors.forename: AmanPreet
authors.initials: A
authors.lastname: Badhwar
authors.affiliation: Douglas Mental Health University Institute, Research Centre, Montreal, QC, Canada; Centre de recherche de l'institut universitaire de gériatrie de Montréal, QC, Canada.
authors.forename: Pierre
authors.initials: P
authors.lastname: Orban
authors.affiliation: Centre de recherche de l'institut universitaire de gériatrie de Montréal, QC, Canada; Université de Montréal, QC, Canada.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Belleville
authors.affiliation: McGill University, Montreal, QC, Canada.
authors.forename: Howard
authors.initials: H
authors.lastname: Chertkow
authors.affiliation: McGill University, Montreal, QC, Canada.
authors.forename: Alain
authors.initials: A
authors.lastname: Dagher
authors.affiliation: Centre de recherche de l'institut universitaire de gériatrie de Montréal, QC, Canada; University of Calgary, AB, Canada; Hotchkiss Brain Institute, Calgary, AB, Canada.
authors.forename: Alexandru
authors.initials: A
authors.lastname: Hanganu
authors.affiliation: Centre de recherche de l'institut universitaire de gériatrie de Montréal, QC, Canada; Université de Montréal, QC, Canada; University of Calgary, AB, Canada; Hotchkiss Brain Institute, Calgary, AB, Canada.
authors.forename: Oury
authors.initials: O
authors.lastname: Monchi
authors.affiliation: McGill University, Montreal, QC, Canada; Douglas Mental Health University Institute, Research Centre, Montreal, QC, Canada.
authors.forename: Pedro
authors.initials: P
authors.lastname: Rosa-Neto
authors.affiliation: McGill University, Montreal, QC, Canada.
authors.forename: Amir
authors.initials: A
authors.lastname: Shmuel
authors.affiliation: McGill University, Montreal, QC, Canada; Douglas Mental Health University Institute, Research Centre, Montreal, QC, Canada.
authors.forename: John
authors.initials: J
authors.lastname: Breitner
authors.affiliation: Centre de recherche de l'institut universitaire de gériatrie de Montréal, QC, Canada; Université de Montréal, QC, Canada.
authors.forename: Pierre
authors.initials: P
authors.lastname: Bellec