title: Effects of the Dietary Detoxification Program on Serumγ-glutamyltransferase, Anthropometric Data and Metabolic Biomarkers in Adults.
abstract: BACKGROUND
  Persistent Organic Pollutants (POPs) are well-known environmental contaminants which are associated with chronic diseases. As foods are the major sources of human exposure to toxic pollutants, we developed an integrated dietary and education program to eliminate the chemical toxin throughout the human body. The present study evaluated effects of the dietary detoxification program on serumγ-glutamyltransferase (GGT), anthropometric data and metabolic biomarkers in adults.
  
  
  METHODS
  Single-armed, pre-post study was conducted from June 2013 to June 2015 at a health examination center and a public health center in Seoul, Korea. Sixty eight subjects (mean age of 52.4 years) were recruited. Subjects participated 20 hours' dietary education sessions. On-line coaching with SNS was performed to enhance participants' proper protocol compliance. Physical and laboratory examinations were assessed at week 0 and 3.
  
  
  RESULTS
  Changes of the serum GGT were correlated with reductions of the body fat percentage (r = .379, p = .001), body fat mass (r = .435, p = .000) and fasting blood glucose (r = .423, p = .000). Serum GGT, weight, body fat percentage, body fat mass, waist circumference, LDL-cholesterol, HDL-cholesterol, triglyceride, total cholesterol, and blood pressure of all participants were reduced with statistical significance in 3 weeks. In metabolic syndrome group, total cholesterol (p = .049), fasting blood glucose (p = .002), and systolic blood pressure (p = .001) were significantly reduced comparison to non-metabolic syndrome group.
  
  
  CONCLUSIONS
  This dietary detoxification program might decrease serum GGT which indicated the overall toxic burden in the body. Anthropometric data and metabolic biomarkers were improved. The integrated dietary and education detoxification program seemed to be a protective intervention for elimination of toxicants from the body.
authors.affiliation: College of Nursing, Seoul National University, Seoul, Korea.
authors.forename: Ju Ah
authors.initials: JA
authors.lastname: Kim
authors.affiliation: Research Institute of Nursing Science, Seoul National University, Seoul, Korea.
authors.forename: Jin Young
authors.initials: JY
authors.lastname: Kim
authors.affiliation: College of Nursing, Seoul National University, Seoul, Korea; Research Institute of Nursing Science, Seoul National University, Seoul, Korea.
authors.forename: Seung Wan
authors.initials: SW
authors.lastname: Kang
keywords: Detoxification; Persistent organic pollutant; Toxins; metabolic syndrome; γ-glutamyltransferase