title: Serum thyroid-stimulating hormone level and relation with size of hippocampus in patients with mild cognitive disorders.
abstract: BACKGROUND
  Cognitive disorders and dementia are common problems, and Alzheimer's disease is one of the major leading causes of death worldwide. Thyroid hormone disorders as a common problem effect on hippocampus size which as a prognostic factor in dementia. The aim of the present study was to investigate the relationship between serum thyroid-stimulating hormone (TSH) level and the size of hippocampus in patients with mild cognitive disorders.
  
  
  METHODS
  In a descriptive-analytical study, 41 patients with symptoms of mild cognitive disorders whom referred to take the brain magnetic resonance image (MRI) in a radiology center under the direction of Tabriz University of Medical Sciences (Tabriz, Iran) were evaluated. The right and left hippocampal and brain volume was calculated by MRI at coronal T1-weighted. Serum TSH level was also measured in these patients. Correlation between serum TSH level and hippocampal volume size was evaluated.
  
  
  RESULTS
  Male to female ratio was 1.05:1 with mean age of 54.09 ± 3.11 years. Mean serum TSH level of patients was 1.55 ± 1.45 uU/ml. The right and left hippocampal volumes were 1.61 ± 0.42 and 1.62 ± 0.39 ml, respectively. There were slight negative correlations between the right and left hippocampal volumes with TSH level (r= -0.133 andr= -0.092, respectively). Correlations between the right and left hippocampal volumes with TSH level were not statistically significant (P= 0.406,P= 0.566, respectively).
  
  
  CONCLUSIONS
  Based on findings of the present study, there was a weak negative correlation between serum level of TSH with the right and left hippocampal and brain volume ratio, but the correlation was not statistically significant. It seems that controlling of clinical or subclinical hypothyroidism may have a role in slowing of dementia progression and also have a preventive role.
authors.affiliation: Department of Radiology and Nuclear Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Mohammad-Hossein
authors.initials: MH
authors.lastname: Daghighi
authors.affiliation: Department of Radiology and Nuclear Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Masoud
authors.initials: M
authors.lastname: Poureisa
authors.affiliation: Department of Radiology and Nuclear Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Pegah
authors.initials: P
authors.lastname: Ahmadi
authors.affiliation: Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Reshadatjoo
authors.affiliation: Department of Radiology and Nuclear Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Sahar
authors.initials: S
authors.lastname: Golestani
authors.affiliation: Medical Philosophy and History Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Naghavi-Behzad
authors.affiliation: Students' Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Farid
authors.initials: F
authors.lastname: Karkon-Shayan
keywords: Alzheimer's disease; dementia; hippocampus size; thyroid-stimulating hormone