title: Squamous cell carcinoma of the extrahepatic bile duct with metachronous para-aortic lymph node metastasis successfully treated with S-1 plus cisplatin.
abstract: The most common histological classification of bile duct cancer is adenocarcinoma and squamous cell carcinoma (SCC) is relatively rare. We report a case of a 78-year-old man with SCC of the extrahepatic bile duct associated with metachronous para-aortic lymph node metastasis. He had undergone subtotal stomach-preserving pancreatoduodenectomy. The pathological findings demonstrated moderately differentiated SCC of the distal extrahepatic bile duct (T1N1M0, stage IIB). 6 months after surgery, recurrence of the para-aortic lymph node was shown in abdominal CT. 5 courses of tegafur/gimeracil/oteracil (S-1) plus cisplatin therapy was performed and the para-aortic lymph node disappeared, confirmed as complete response by imaging findings. The patient is alive without recurrence, 10 months after recurrence and chemotherapy.
authors.affiliation: Department of Surgery, Tokyo Women's Medical University Medical Center East, Tokyo, Japan.
authors.forename: Ryohei
authors.identifier: http://orcid.org/0000-0001-9216-4800
authors.initials: R
authors.lastname: Nishiguchi
authors.affiliation: Department of Surgery, Sainokuni Higashi Omiya Medical Center, Saitama, Japan.
authors.forename: Dal Ho
authors.initials: DH
authors.lastname: Kim
authors.affiliation: Department of Surgery, Sainokuni Higashi Omiya Medical Center, Saitama, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Honda
authors.affiliation: Department of Surgery, Sainokuni Higashi Omiya Medical Center, Saitama, Japan.
authors.forename: Tsuguo
authors.initials: T
authors.lastname: Sakamoto
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D001650:Bile Duct Neoplasms / Q000188:drug therapy / Q000473:pathology*; D017734:Bile Ducts, Extrahepatic; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000188:drug therapy / Q000556:secondary*; D002760:Cholangiopancreatography, Endoscopic Retrograde; D002945:Cisplatin / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D016609:Neoplasms, Second Primary; D010094:Oxonic Acid / Q000008:administration & dosage*; D005641:Tegafur / Q000008:administration & dosage*; D014057:Tomography, X-Ray Computed
chemical_list: D000964:Antimetabolites, Antineoplastic; D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D002945:Cisplatin