title: Developmentally defined forebrain circuits regulate appetitive and aversive olfactory learning.
abstract: Postnatal and adult neurogenesis are region- and modality-specific, but the significance of developmentally distinct neuronal populations remains unclear. We demonstrate that chemogenetic inactivation of a subset of forebrain and olfactory neurons generated at birth disrupts responses to an aversive odor. In contrast, novel appetitive odor learning is sensitive to inactivation of adult-born neurons, revealing that developmentally defined sets of neurons may differentially participate in hedonic aspects of sensory learning.
authors.affiliation: Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA.
authors.forename: Nagendran
authors.initials: N
authors.lastname: Muthusamy
authors.affiliation: Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA.
authors.forename: Xuying
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA.
authors.forename: Caroline A
authors.initials: CA
authors.lastname: Johnson
authors.affiliation: Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, India.
authors.forename: Prem N
authors.initials: PN
authors.lastname: Yadav
authors.affiliation: Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA.
authors.forename: H Troy
authors.initials: HT
authors.lastname: Ghashghaei
mesh_terms: D000818:Animals; D001070:Appetitive Behavior / Q000502:physiology*; D001362:Avoidance Learning / Q000502:physiology*; D001522:Behavior, Animal / Q000502:physiology*; D003214:Conditioning, Classical / Q000502:physiology*; D008297:Male; D051379:Mice; D055495:Neurogenesis / Q000502:physiology; D009474:Neurons / Q000502:physiology; D066194:Olfactory Cortex / Q000502:physiology; D012903:Smell / Q000502:physiology*