title: Application of Abbreviated Protocol of Magnetic Resonance Imaging for Breast Cancer Screening in Dense Breast Tissue.
abstract: The study aimed to evaluate the usefulness of an abbreviated protocol (AP) of magnetic resonance imaging (MRI) in comparison to a full diagnostic protocol (FDP) of MRI in the breast cancer screening with dense breast tissue.
  
  
  
  There are 478 female participants with dense breast tissue and negative mammography results, who were imaged with MRI using AP and FDP. The AP and FDP images were analyzed separately, and the sensitivity and specificity of breast cancer detection were calculated. The chi-square test and receiver operating characteristics curves were used to assess the breast cancer diagnostic capabilities of the two protocols.
  
  
  
  Sixteen cases of breast cancer from 478 patients with dense breasts were detected using the FDP method, with pathologic confirmation of nine cases of ductal carcinoma in situ, six cases of invasive ductal carcinoma, and one case of mucinous carcinoma. Fifteen cases of breast cancer were successfully screened using the AP method. The sensitivity showed no obvious significant difference between AP and FDP (χ2= 0.592, P = 0.623), but the specificity showed a statistically significant difference (χ2= 4.619, P = 0.036). The receiver operating characteristics curves showed high efficacy of both methods in the detection of breast cancer in dense breast tissue (the areas under the curve were 0.931 ± 0.025 and 0.947 ± 0.024, respectively), and the ability to diagnose breast cancer was not statistically significantly different between the two methods.
  
  
  
  The AP of MRI may improve the detection rate of breast cancer in dense breast tissue, and it may be useful in efficient breast cancer screening.
authors.affiliation: Department of Radiology, The Affiliated Suzhou Hospital, Nanjing Medical University, No.16, Bai-Ta-Xi Road, Suzhou 215001, China. Electronic address: sznaonao@163.com.
authors.forename: Shuang-Qing
authors.initials: SQ
authors.lastname: Chen
authors.affiliation: Breast Imaging Screening Center, The Affiliated Suzhou Hospital, Nanjing Medical University, Suzhou, China.
authors.forename: Min
authors.initials: M
authors.lastname: Huang
authors.affiliation: Department of Radiology, The Affiliated Suzhou Hospital, Nanjing Medical University, No.16, Bai-Ta-Xi Road, Suzhou 215001, China.
authors.forename: Yu-Ying
authors.initials: YY
authors.lastname: Shen
authors.affiliation: Department of Radiology, The Affiliated Suzhou Hospital, Nanjing Medical University, No.16, Bai-Ta-Xi Road, Suzhou 215001, China.
authors.forename: Chen-Lu
authors.initials: CL
authors.lastname: Liu
authors.affiliation: Breast Imaging Screening Center, The Affiliated Suzhou Hospital, Nanjing Medical University, Suzhou, China.
authors.forename: Chuan-Xiao
authors.initials: CX
authors.lastname: Xu
mesh_terms: D000328:Adult; D000368:Aged; D001940:Breast / Q000000981:diagnostic imaging; D000071060:Breast Density / Q000502:physiology*; D001943:Breast Neoplasms / Q000000981:diagnostic imaging*; D055088:Early Detection of Cancer / Q000379:methods; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008327:Mammography / Q000379:methods*; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
keywords: Breast cancer; abbreviated protocol; breast screening; magnetic resonance imaging