title: Modelling mitral valvular dynamics-current trend and future directions.
abstract: Dysfunction of mitral valve causes morbidity and premature mortality and remains a leading medical problem worldwide. Computational modelling aims to understand the biomechanics of human mitral valve and could lead to the development of new treatment, prevention and diagnosis of mitral valve diseases. Compared with the aortic valve, the mitral valve has been much less studied owing to its highly complex structure and strong interaction with the blood flow and the ventricles. However, the interest in mitral valve modelling is growing, and the sophistication level is increasing with the advanced development of computational technology and imaging tools. This review summarises the state-of-the-art modelling of the mitral valve, including static and dynamics models, models with fluid-structure interaction, and models with the left ventricle interaction. Challenges and future directions are also discussed.
authors.affiliation: School of Mathematics and Statistics, University of Glasgow, UK.
authors.forename: Hao
authors.identifier: 0000-0001-6852-9435
authors.initials: H
authors.lastname: Gao
authors.affiliation: School of Mathematics and Statistics, University of Glasgow, UK.
authors.forename: Nan
authors.initials: N
authors.lastname: Qi
authors.affiliation: School of Mathematics and Statistics, University of Glasgow, UK.
authors.forename: Liuyang
authors.initials: L
authors.lastname: Feng
authors.affiliation: Bioengineering College, Chongqing University, China.
authors.forename: Xingshuang
authors.initials: X
authors.lastname: Ma
authors.affiliation: Department of Cardiac Surgery, Royal Hospital for Children, Glasgow, UK.
authors.forename: Mark
authors.initials: M
authors.lastname: Danton
authors.affiliation: Institute of Cardiovascular and Medical Sciences, University of Glasgow, UK.
authors.forename: Colin
authors.initials: C
authors.lastname: Berry
authors.affiliation: School of Mathematics and Statistics, University of Glasgow, UK.
authors.forename: Xiaoyu
authors.identifier: 0000-0002-8753-4210
authors.initials: X
authors.lastname: Luo
mesh_terms: D000818:Animals; D004452:Echocardiography; D006439:Hemodynamics; D019028:Magnetic Resonance Imaging, Cine; D008943:Mitral Valve / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000502:physiology*; D008955:Models, Cardiovascular; D013552:Swine; D014057:Tomography, X-Ray Computed
keywords: fluid-structure interaction; left ventricle; mitral valve; numerical methods; soft tissue