title: Gelatin microspheres containing calcitonin gene-related peptide or substance P repair bone defects in osteoporotic rabbits.
abstract: OBJECTIVE
  To investigate the therapeutic effect of gelatin microspheres containing different concentrations of calcitonin gene-related peptide (CGRP) or substance P on repairing bone defects in a rabbit osteoporosis model.
  
  
  RESULTS
  Gelatin microspheres containing different concentrations of CGRP or substance P promoted osteogenesis after 3 months in a rabbit osteoporotic bone defective model. From micro-computed tomography imaging results, 10 nM CGRP was optimal for increasing the trabecular number and decreasing the trabecular bone separation degree; similar effects were observed with the microspheres containing 1 µM substance P. Histological analysis showed that the gelatin microspheres containing CGRP or substance P, regardless of the concentration, effectively promoted osteogenesis, and the highest effect was achieved in the groups containing 1 µM CGRP or 1 µM substance P.
  
  
  CONCLUSIONS
  Gelatin microspheres containing CGRP or substance P effectively promoted osteogenesis in a rabbit osteoporotic bone defect model dose-dependently, though their effects in repairing human alveolar ridge defects still need further investigation.
authors.affiliation: State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Clinical Research Center of Oral Diseases, Department of Oral Surgery, School of Stomatology, The Fourth Military Medical University, 145 Western Changle Road, Xi'an, 710032, People's Republic of China.
authors.forename: Jianghao
authors.initials: J
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Clinical Research Center of Oral Diseases, Department of Oral Surgery, School of Stomatology, The Fourth Military Medical University, 145 Western Changle Road, Xi'an, 710032, People's Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.affiliation: Department of Stomatology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China.
authors.forename: Jinxiu
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Stomatology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China.
authors.forename: Cong
authors.initials: C
authors.lastname: Sun
authors.affiliation: State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Clinical Research Center of Oral Diseases, Department of Oral Surgery, School of Stomatology, The Fourth Military Medical University, 145 Western Changle Road, Xi'an, 710032, People's Republic of China.
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Clinical Research Center of Oral Diseases, Department of Oral Surgery, School of Stomatology, The Fourth Military Medical University, 145 Western Changle Road, Xi'an, 710032, People's Republic of China.
authors.forename: Kaijin
authors.initials: K
authors.lastname: Hu
authors.affiliation: State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Clinical Research Center of Oral Diseases, Department of Oral Surgery, School of Stomatology, The Fourth Military Medical University, 145 Western Changle Road, Xi'an, 710032, People's Republic of China.
authors.forename: Linlin
authors.initials: L
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Clinical Research Center of Oral Diseases, Department of Oral Surgery, School of Stomatology, The Fourth Military Medical University, 145 Western Changle Road, Xi'an, 710032, People's Republic of China. yxding@fmmu.edu.cn.
authors.forename: Yuxiang
authors.initials: Y
authors.lastname: Ding
mesh_terms: D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000187:drug effects / Q000473:pathology*; D015740:Calcitonin Gene-Related Peptide / Q000494:pharmacology / Q000627:therapeutic use*; D003692:Delayed-Action Preparations; D004195:Disease Models, Animal; D005260:Female; D005780:Gelatin / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D010024:Osteoporosis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D010052:Ovariectomy; D011817:Rabbits; D013194:Staining and Labeling; D013373:Substance P / Q000494:pharmacology / Q000627:therapeutic use*; D014945:Wound Healing / Q000187:drug effects; D055114:X-Ray Microtomography
chemical_list: D003692:Delayed-Action Preparations; D013373:Substance P; D005780:Gelatin; D015740:Calcitonin Gene-Related Peptide
keywords: Bone defect; Bone repair; Calcitonin gene-related peptide; Gelatin microspheres; Osteoporosis; Substance P