title: Correlation between functional mobility and cognitive performance in older adults with cognitive impairment.
abstract: Association between cognitive impairment and gait performance occurs in mild cognitive impairment (MCI) and Alzheimer's disease (AD), particularly under "divided attention" conditions, leading to a greater risk of falls. We studied 36 controls, 42 MCI, and 26 mild AD patients, using the Timed Up-and-Go test (TUG) under four conditions: TUG single - TUG1; TUG cognitive - TUG2; TUG manual -TUG3; TUG cognitive and manual - TUG4. Cognition was assessed using the MMSE, SKT, Exit25, and TMT (A and B). We found significant correlations between cognitive scores and TUG2 [r values (MMSE: -0.383, TMT-A: 0.430, TMT-B: 0.386, Exit25: 0.455, SKT: 0.563)] and TUG4 [(MMSE: -0.398, TMT-A: 0.384, TMT-B: 0.352,Exit25: 0.466, SKT: 0.525)] in the AD group, and between all TUG modalities and SKT in MCI and AD. Our results revealed that functional mobility impairment in cognitive dual tasks correlated to cognitive decline in AD patients and to attention and memory impairment in MCI.
authors.affiliation: a Laboratory of Neuroscience (LIM-27), Department and Institute of Psychiatry, Faculty of Medicine , University of São Paulo , São Paulo , Brazil.|b Faculty of Physical Therapy , Santa Cecilia University , Santos , Brazil.
authors.forename: Sheila de Melo
authors.initials: SM
authors.lastname: Borges
authors.affiliation: a Laboratory of Neuroscience (LIM-27), Department and Institute of Psychiatry, Faculty of Medicine , University of São Paulo , São Paulo , Brazil.
authors.forename: Márcia
authors.initials: M
authors.lastname: Radanovic
authors.affiliation: a Laboratory of Neuroscience (LIM-27), Department and Institute of Psychiatry, Faculty of Medicine , University of São Paulo , São Paulo , Brazil.
authors.forename: Orestes Vicente
authors.initials: OV
authors.lastname: Forlenza
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000503:physiopathology; D001288:Attention; D003071:Cognition; D060825:Cognitive Dysfunction / Q000503:physiopathology; D015331:Cohort Studies; D005260:Female; D005684:Gait; D006801:Humans; D008297:Male; D008875:Middle Aged
keywords: Functional mobility; cognitive impairment; cognitive performance; divided attention task