title: Effect of curcumin on kidney histopathological changes, lipid peroxidation and total antioxidant capacity of serum in sodium arsenite-treated mice.
abstract: Sodium arsenite is an environmental pollutant with the ability to generate free radicals and curcumin acts as a potent antioxidant. This study investigates the effect of curcumin on kidney histopathology, lipid peroxidation and antioxidant capacity of serum in the mice treated with sodium arsenite. Adult male mice were divided into four groups: control, sodium arsenite, curcumin and curcumin+sodium arsenite. The treatments were delivered for 5 weeks. After the treatment period, blood samples were collected and the concentrations of malondialdehyde (MDA) and total antioxidant capacity of serum were determined. Left kidney was dissected, weighed and used for histopathological and histomorphometrical studies. Sodium arsenite-treated mice showed a significant decrease in the diameter of glomerulus and proximal tubule, glomerular area, total antioxidant capacity of serum as well as a significant increase in serum concentration of MDA compared to the control group. However, no significant difference was found in kidney weight, area and diameter of Bowman's capsule as well as the diameter of distal tubule in mice treated with sodium arsenite compared to the control. In curcumin+sodium arsenite group, curcumin significantly reversed the adverse effects of sodium arsenite on the diameter of glomerulus and proximal tubule, glomerular area, total antioxidant capacity of serum and serum concentration of MDA compared to the sodium arsenite group. The application of curcumin alone significantly increased the total antioxidant capacity of serum compared to the control. Curcumin compensated the adverse effects of sodium arsenite on kidney tissue, lipid peroxidation and total antioxidant capacity of serum.
authors.affiliation: Biology Department, Faculty of Science, Arak University, Arak 38156-8-8349, Iran. Electronic address: h-momeni@araku.ac.ir.
authors.forename: Hamid Reza
authors.initials: HR
authors.lastname: Momeni
authors.affiliation: Biology Department, Faculty of Science, Arak University, Arak 38156-8-8349, Iran. Electronic address: neskandari@araku.ac.ir.
authors.forename: Najmeh
authors.initials: N
authors.lastname: Eskandari
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D018053:Arsenites / Q000633:toxicity*; D003474:Curcumin / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000633:toxicity; D007668:Kidney / Q000187:drug effects*; D007674:Kidney Diseases / Q000139:chemically induced / Q000517:prevention & control; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D051379:Mice; D017670:Sodium Compounds / Q000633:toxicity*
chemical_list: D000975:Antioxidants; D018053:Arsenites; D004791:Enzyme Inhibitors; D017670:Sodium Compounds; C017947:sodium arsenite; D003474:Curcumin
keywords: Adult mouse; Antioxidant capacity; Curcumin; Kidney; Malondialdehyde; Sodium arsenite