title: [The clinical significance of Delphian lymph node metastasis in papillary thyroid cancer].
abstract: Objective:To evaluate the clinical significance of Delphian lymph node (DLN) metastasis in papillary thyroid cancer (PTC).Method:A total of 505 cases with PTC confirmed pathologically in our hospital between January 2015 and December 2015 were retrospectively reviewed. 208 patients with DLN assessed separately by histopathologic examination who underwent primary surgery for PTC were included for the following analysis.Results:In 208 patients, the detection rate of DLN was 63.0% and the metastasis rate of DLN was 21.4%. DLN metastasis was correlated with PTC multifocality (P=0.038), tumor size over 1cm (P=0.001),BRAFV600Emutation (P=0.017) and central neck node metastasis (P<0.001). Tumor size over 1cm (95%CI1.308-9.909,OR=3.600,P=0.013) and the number of node with central neck metastasis (95%CI1.313-2.163,OR=1.685,P<0.001) were independent risk factors for DLN metastasis. The presence of DLN metastasis was associated with an 8.8-fold higher frequency of central neck node metastasis compared to cases without DLN metastasis. Among patients with DLN metastases, central lymph node metastasis was more common in the cases with lateral neck node metastases compared to those without lateral neck node metastases (6.5±3.0 vs 1.5±0.7,P=0.009), and 5 of the 6 patients also presented with PTC multifocality andBRAFV600Emutation.Conclusion:DLN metastasis implies a higher possibility of central neck lymph node metastasis. DLN should be assessed during operation to provide information for neck dissection, post-operative administration and follow-up strategy.
authors.affiliation: Department of Thyroid, Department of Otolaryngology Head and Neck Surgery, the Affiliated Yantai Yuhuangding Hospital of Qingdao University.Yantai 264000, China.
authors.forename: G B
authors.initials: GB
authors.lastname: Zheng
authors.affiliation: Department of Thyroid, Department of Otolaryngology Head and Neck Surgery, the Affiliated Yantai Yuhuangding Hospital of Qingdao University.Yantai 264000, China.
authors.forename: S L
authors.initials: SL
authors.lastname: Hao
authors.affiliation: Department of Thyroid, Department of Otolaryngology Head and Neck Surgery, the Affiliated Yantai Yuhuangding Hospital of Qingdao University.Yantai 264000, China.
authors.forename: X C
authors.initials: XC
authors.lastname: Liu
authors.affiliation: Department of Thyroid, Department of Otolaryngology Head and Neck Surgery, the Affiliated Yantai Yuhuangding Hospital of Qingdao University.Yantai 264000, China.
authors.forename: J Y
authors.initials: JY
authors.lastname: Ning
authors.affiliation: Department of Thyroid, Department of Otolaryngology Head and Neck Surgery, the Affiliated Yantai Yuhuangding Hospital of Qingdao University.Yantai 264000, China.
authors.forename: G C
authors.initials: GC
authors.lastname: Wu
authors.affiliation: Department of Thyroid, Department of Otolaryngology Head and Neck Surgery, the Affiliated Yantai Yuhuangding Hospital of Qingdao University.Yantai 264000, China.
authors.forename: D
authors.initials: D
authors.lastname: Wang
authors.affiliation: Department of Thyroid, Department of Otolaryngology Head and Neck Surgery, the Affiliated Yantai Yuhuangding Hospital of Qingdao University.Yantai 264000, China.
authors.forename: B Y
authors.initials: BY
authors.lastname: Li
authors.affiliation: Department of Thyroid, Department of Otolaryngology Head and Neck Surgery, the Affiliated Yantai Yuhuangding Hospital of Qingdao University.Yantai 264000, China.
authors.forename: L X
authors.initials: LX
authors.lastname: Jiang
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, the Affiliated Yantai Yuhuangding Hospital of Qingdao University. Yantai 264000, China.
authors.forename: X C
authors.initials: XC
authors.lastname: Song
authors.affiliation: Department of Thyroid, Department of Otolaryngology Head and Neck Surgery, the Affiliated Yantai Yuhuangding Hospital of Qingdao University.Yantai 264000, China.
authors.forename: H T
authors.initials: HT
authors.lastname: Zheng
mesh_terms: D002277:Carcinoma / Q000473:pathology / Q000556:secondary*; D002291:Carcinoma, Papillary; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D009154:Mutation; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics; D012189:Retrospective Studies; D012307:Risk Factors; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000473:pathology* / Q000556:secondary; D013965:Thyroidectomy; D047368:Tumor Burden
chemical_list: C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf