title: Association between PTPN22/CTLA-4 Gene Polymorphism and Allergic Rhinitis with Asthma in Children.
abstract: Allergic rhinitis (AR) is an IgE-mediated upper airway disease, and its impact on asthma has been widely recognized. Protein tyrosine phosphatase non-receptor 22 (PTPN22) gene and the cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) gene polymorphisms have been reported to be associated with several immune-related diseases. Here we investigated the reffect of these two genes' polymorphisms on the risk of AR and asthma in Chinese Han children. A total of 106 AR patients, 112 AR with asthma patients, and 109 healthy children were enrolled in the study. The SNPs of PTPN22 (rs2488457, rs1310182, rs3789604) and CTLA-4 (rs3087243, rs11571302, rs11571315, rs231725, rs335219727, and rs4553808) were genotyped using a PCR-restriction fragment length polymorphism assay. For PTPN22, an increased prevalence of the CC genotype and C allele in rs1310182 were identified in AR group. For CTLA-4, AA genotype and A allele in rs3087243 and rs231725 were increased in AR with asthma group while in AR group, AA genotype and A allele in rs231725 were obviously decreased. This study reveals a significant association between SNPs in PTPN22, CTLA-4 gene and AR with asthma in Chinese Han children, which might be susceptibility factors for AR and asthma.
authors.affiliation: Department of Otorhinolaryngology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Shang Hua
authors.initials: SH
authors.lastname: Song
authors.affiliation: Department of Otorhinolaryngology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Xiao Qiang
authors.initials: XQ
authors.lastname: Wang
authors.affiliation: Department of Otorhinolaryngology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Shen
authors.affiliation: Department of Otorhinolaryngology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Su Ling
authors.initials: SL
authors.lastname: Hong
authors.affiliation: Department of Otorhinolaryngology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Ke
mesh_terms: D000293:Adolescent; D044466:Asian People; D001249:Asthma / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology; D060908:CTLA-4 Antigen / Q000235:genetics* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D020641:Polymorphism, Single Nucleotide; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22 / Q000235:genetics* / Q000276:immunology; D065631:Rhinitis, Allergic / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology
chemical_list: D060908:CTLA-4 Antigen; C516765:PTPN22 protein, human; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22
keywords: Allergic rhinitis; Asthma; Cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4); Genetic polymorphism; Pediatrics; Protein tyrosine phosphatase non-receptor 22 (PTPN22); Single nucleotide polymorphism (SNP)