title: [Raynaud's phenomenon].
abstract: Raynaud's phenomenon (RP) is a very common sign which can usually be seen across all medical specialties. It is characterized by episodic color changes of acral parts of the body (palor, cyanosis, rubor) lasting from a few minutes to hours, which are usually triggered by cold temperature and/or stress. The primary RP occurs alone, without concomitant diseases, is usually benign and has favorable prognosis. Secondary RP occurs in a variety of diseases with a very variable progression and prognosis, mostly unfavorable one due to the development of ischemic tissue necrosis and gangrene. This work provides a comprehensive overview of the history, current knowledge about the epidemiology and pathogenesis and the recommended evaluation and treatment of RP.
authors.forename: Michal
authors.initials: M
authors.lastname: Tomčík
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000627:therapeutic use; D006801:Humans; D010808:Physical Examination / Q000379:methods*; D011928:Raynaud Disease / Q000175:diagnosis* / Q000188:drug therapy*; D012216:Rheumatic Diseases / Q000175:diagnosis
chemical_list: D000317:Adrenergic alpha-Antagonists; D000959:Antihypertensive Agents
keywords: Raynaud's phenomenon; capillaroscopy treatment.; primary; secondary