title: Pd Catalysis in Cyanide-Free Synthesis of Nitriles from Haloarenes via Isoxazolines.
abstract: A method to obtain aryl nitriles from the corresponding halides by Pd catalysis, in the absence of any cyanide source, is reported. The reaction of an aryl halide, ethyl nitroacetate, and an olefin readily delivers an aromatic nitrile. A variety of aryl iodides/bromides have been converted into the corresponding cyanoarenes in fair to excellent yields. The reaction likely involves the following steps: (a) Pd-catalyzed α-arylation of ethyl nitroacetate; (b) nitrile oxide formation;
authors.affiliation: Dipartimento di Chimica and CIRCC, Università di Parma , Parco Area delle Scienze, 17/A, 43124 Parma, Italy.|Institut de Chimie des Substances Naturelles, ICSN-CNRS UPR 2301 , Gif/Yvette Cedex 91198, France.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Maestri
authors.affiliation: Institut de Chimie des Substances Naturelles, ICSN-CNRS UPR 2301 , Gif/Yvette Cedex 91198, France.
authors.forename: Tatiana
authors.initials: T
authors.lastname: Cañeque
authors.affiliation: Dipartimento di Chimica and CIRCC, Università di Parma , Parco Area delle Scienze, 17/A, 43124 Parma, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Della Ca'
authors.affiliation: Institut Parisien de Chimie Moléculaire, UPMC Université Paris 06, IPCM-UMR 8232 , Paris 75005 Cedex, France.
authors.forename: Etienne
authors.initials: E
authors.lastname: Derat
authors.affiliation: Dipartimento di Chimica and CIRCC, Università di Parma , Parco Area delle Scienze, 17/A, 43124 Parma, Italy.
authors.forename: Marta
authors.initials: M
authors.lastname: Catellani
authors.affiliation: Dipartimento di Chimica and CIRCC, Università di Parma , Parco Area delle Scienze, 17/A, 43124 Parma, Italy.
authors.forename: Gian Paolo
authors.initials: GP
authors.lastname: Chiusoli
authors.affiliation: Institut de Chimie des Substances Naturelles, ICSN-CNRS UPR 2301 , Gif/Yvette Cedex 91198, France.|Institut Parisien de Chimie Moléculaire, UPMC Université Paris 06, IPCM-UMR 8232 , Paris 75005 Cedex, France.
authors.forename: Max
authors.initials: M
authors.lastname: Malacria