title: Effects of Phenotype of Retinal Macrophages on the Features of Angiogenesis of Murine Retina.
abstract: The period of forming of superficial vascular plexus during physiological retinal angiogenesis was shorter in C57Bl/6 mice. Experiments on the model of oxygen-induced retinopathy showed that avascular and vascularized zones in BALB/c mice on day 17 are smaller than in C57Bl/6 mice are by 5 and 1.5 times, respectively. The obtained results confirmed the importance of phenotype of retinal macrophages in the regulation of processes of both physiological and pathological retinal angiogenesis.
authors.affiliation: A. I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Healthcare of the Russian Federation, Moscow, Russia. svlvs@mail.ru.
authors.forename: S V
authors.initials: SV
authors.lastname: Lyamina
authors.affiliation: A. I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Healthcare of the Russian Federation, Moscow, Russia.
authors.forename: O Yu
authors.initials: OY
authors.lastname: Komova
authors.affiliation: A. I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Healthcare of the Russian Federation, Moscow, Russia.
authors.forename: N A
authors.initials: NA
authors.lastname: Gavrilova
authors.affiliation: A. I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Healthcare of the Russian Federation, Moscow, Russia.
authors.forename: I Yu
authors.initials: IY
authors.lastname: Malyshev
mesh_terms: D000818:Animals; D016650:Fluorescein-5-isothiocyanate / Q000737:chemistry; D058437:Hypertensive Retinopathy / Q000139:chemically induced / Q000276:immunology / Q000473:pathology*; D007150:Immunohistochemistry; D016130:Immunophenotyping; D008264:Macrophages / Q000145:classification / Q000166:cytology* / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009389:Neovascularization, Pathologic / Q000139:chemically induced / Q000276:immunology / Q000473:pathology*; D018919:Neovascularization, Physiologic / Q000276:immunology; D010100:Oxygen / Q000009:adverse effects; D010641:Phenotype; D037121:Plant Lectins / Q000737:chemistry; D012160:Retina / Q000276:immunology / Q000473:pathology*; D015861:Retinal Neovascularization / Q000139:chemically induced / Q000276:immunology / Q000473:pathology*; D013045:Species Specificity; D019809:Streptavidin / Q000737:chemistry
chemical_list: C045475:Griffonia simplicifolia lectins; D037121:Plant Lectins; D019809:Streptavidin; D016650:Fluorescein-5-isothiocyanate; D010100:Oxygen
keywords: macrophages; phenotype; retinal angiogenesis