title: Probing T-cell Infiltration in Tumors.
abstract: A recent study suggests that the absence of infiltrating T cells in some tumors is not because they lack neoantigens. Comparing melanoma samples with and without T cell-driven inflammation, researchers found no differences in mutational load and neoantigen density. Noninflamed tumors, however, lacked a subset of dendritic cells that helps promote T-cell infiltration.
mesh_terms: D000951:Antigens, Neoplasm / Q000235:genetics; D006801:Humans; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology*; D008545:Melanoma / Q000235:genetics / Q000276:immunology*; D009154:Mutation; D012878:Skin Neoplasms / Q000235:genetics / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D000951:Antigens, Neoplasm