title: Synthesis of novel C4-benzazole naphthalimide derivatives with potent anti-tumor properties against murine melanoma.
abstract: Novel C4-benzazole naphthalimide derivatives were synthesized and tested in vitro and in vivo as anti-cancer drugs. Among these synthetic molecules, compounds 9 and 10 exhibited cytotoxicity against murine B16F10 melanoma cells. In addition, the above-mentioned compounds significantly suppressed lung tumor metastasis with no visible sign of toxicity.
authors.affiliation: Chest Division, Medical Department, MacKay Memorial Hospital, Zhongshan Dist., 10449 Taipei, Taiwan.
authors.forename: Yen-Ta
authors.initials: YT
authors.lastname: Lu
authors.affiliation: Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, MacKay Memorial Hospital, Zhongshan Dist., 10449 Taipei, Taiwan.
authors.forename: Tien-Ling
authors.initials: TL
authors.lastname: Chen
authors.affiliation: Department of Emergency Medicine, MacKay Memorial Hospital, Zhongshan Dist., 10449 Taipei, Taiwan; Department of Medicine, MacKay Medical College, New Taipei City 25245, Taiwan.
authors.forename: Kuo-Song
authors.initials: KS
authors.lastname: Chang
authors.affiliation: Department of Medical Research, MacKay Memorial Hospital, Tamsui Dist., 25173 New Taipei City, Taiwan.
authors.forename: Chia-Ming
authors.initials: CM
authors.lastname: Chang
authors.affiliation: Department of Medical Research, MacKay Memorial Hospital, Tamsui Dist., 25173 New Taipei City, Taiwan.
authors.forename: Tsai-Yin
authors.initials: TY
authors.lastname: Wei
authors.affiliation: Department of Chemistry, Tamkang University, Tamsui Dist., 25137 New Taipei City, Taiwan.
authors.forename: Jen-Wei
authors.initials: JW
authors.lastname: Liu
authors.affiliation: Department of Chemistry, Tamkang University, Tamsui Dist., 25137 New Taipei City, Taiwan.
authors.forename: Chih-Ang
authors.initials: CA
authors.lastname: Hsiao
authors.affiliation: Department of Chemistry, Tamkang University, Tamsui Dist., 25137 New Taipei City, Taiwan. Electronic address: tlshih@mail.tku.edu.tw.
authors.forename: Tzenge-Lien
authors.initials: TL
authors.lastname: Shih
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004250:DNA Topoisomerases, Type II / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D005260:Female; D008545:Melanoma / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D015394:Molecular Structure; D053644:Naphthalimides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D059005:Topoisomerase II Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D053644:Naphthalimides; D059005:Topoisomerase II Inhibitors; D004250:DNA Topoisomerases, Type II
keywords: B16F10 cells; Benzazole; MTS assay; Melanoma; Naphthalimide; Topoisomerase II