title: Reduced Transplacental Transfer of Group B Streptococcus Surface Protein Antibodies in HIV-infected Mother-Newborn Dyads.
abstract: We evaluated the effect of maternal HIV infection on transplacental antibody transfer specific to 8 group B Streptococcus (GBS) surface proteins among 81 HIV-uninfected and 83 HIV-infected mother-newborn pairs using a multiplex immunoassay. Significantly lower antibody titers were detected in HIV-infected mothers and HIV-exposed uninfected newborns compared to HIV-uninfected mother-newborn dyads. Maternal HIV infection was also associated with reduced transplacental transfer of antibodies for Sip (25.8%), Foldase (30.4%), gba0392 (36.5%), gbs0393 (32.9%), gbs1539 (39.2%), gbs2106 (35.7%), and BibA (19.4%); P < .003. This reduced transplacental antibody might contribute to increased susceptibility for invasive GBS disease in HIV-exposed uninfected infants.
authors.affiliation: Department of Science and Technology/National Research Foundation: Vaccine Preventable Diseases.|MRC, Respiratory and Meningeal Pathogens Research Unit.
authors.forename: Sonwabile
authors.initials: S
authors.lastname: Dzanibe
authors.affiliation: Department of Science and Technology/National Research Foundation: Vaccine Preventable Diseases.|MRC, Respiratory and Meningeal Pathogens Research Unit.
authors.forename: Peter V
authors.initials: PV
authors.lastname: Adrian
authors.affiliation: Department of Science and Technology/National Research Foundation: Vaccine Preventable Diseases.|MRC, Respiratory and Meningeal Pathogens Research Unit.
authors.forename: Sheila Z Kimaro
authors.initials: SZK
authors.lastname: Mlacha
authors.affiliation: Department of Science and Technology/National Research Foundation: Vaccine Preventable Diseases.|MRC, Respiratory and Meningeal Pathogens Research Unit.|Department of Paediatrics, University of the Witwatersrand, Johannesburg, South Africa.
authors.forename: Ziyaad
authors.initials: Z
authors.lastname: Dangor
authors.affiliation: Department of Science and Technology/National Research Foundation: Vaccine Preventable Diseases.|MRC, Respiratory and Meningeal Pathogens Research Unit.
authors.forename: Gaurav
authors.initials: G
authors.lastname: Kwatra
authors.affiliation: Department of Science and Technology/National Research Foundation: Vaccine Preventable Diseases.|MRC, Respiratory and Meningeal Pathogens Research Unit.|National Institutes for Communicable Diseases, Johannesburg, South Africa.
authors.forename: Shabir A
authors.initials: SA
authors.lastname: Madhi
mesh_terms: D000907:Antibodies, Bacterial / Q000097:blood*; D000914:Antibodies, Viral / Q000097:blood*; D005260:Female; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1 / Q000235:genetics; D006801:Humans; D007112:Immunity, Maternally-Acquired; D007118:Immunoassay; D007231:Infant, Newborn / Q000276:immunology; D008431:Maternal-Fetal Exchange / Q000276:immunology; D008565:Membrane Proteins / Q000276:immunology*; D015999:Multivariate Analysis; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology* / Q000821:virology; D012044:Regression Analysis; D013019:South Africa; D013292:Streptococcus agalactiae; D019562:Viral Load
chemical_list: D000907:Antibodies, Bacterial; D000914:Antibodies, Viral; D008565:Membrane Proteins
keywords: HIV; antibodies; group B Streptococcus; surface proteins; trans-placental transfer