title: The Japanese LupusPRO: A cross-cultural validation of an outcome measure for lupus.
abstract: Objective This study aimed to validate the Japanese version of the LupusPRO questionnaire for use with systemic lupus erythematosus patients. Methods Participants were 205 lupus patients recruited from three rheumatology centers in Japan. Demographic data were collected and quality of life was assessed using the LupusPRO and the Short Form Health Survey-12. Disease activity was evaluated by physicians using the Systemic Lupus Erythematosus Activity Index. Some participants completed questionnaires 10-14 days after the first survey. Internal consistency reliability, test-retest reliability, content validity and convergent validity were examined, and confirmatory factor analysis was performed. Results Participants' mean age was 47.8 ± 13.6 years. Older participants scored lower on physical quality of life and higher on coping than younger participants. The LupusPRO showed satisfactory test-retest reliability ( n = 111). Test-retest reliability was lower for the mental and social aspects of quality of life, indicating fluctuations in quality of life during the two-week interval. Internal consistency reliability was good and convergent validity with the corresponding domains of the Short Form Health Survey-12 was satisfactory. Confirmatory factor analysis showed a good model fit. Conclusion The Japanese LupusPRO is a reliable and valid measure to evaluate treatment interventions for systemic lupus erythematosus.
authors.affiliation: 1 Department of Nursing, Graduate School of Medicine, Osaka University, Osaka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Inoue
authors.affiliation: 2 Rheumatology & Collagen Disease Center, Hyogo Prefectural Kakogawa Medical Center, Hyogo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Shiozawa
authors.affiliation: 2 Rheumatology & Collagen Disease Center, Hyogo Prefectural Kakogawa Medical Center, Hyogo, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Yoshihara
authors.affiliation: 3 Rheumatology Center, Kakogawa City Hospital, Hyogo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yamane
authors.affiliation: 4 Department of Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Shima
authors.affiliation: 4 Department of Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Hirano
authors.affiliation: 5 Department of Medicine, Division of Rheumatology, Rush University Medical Center, Chicago, IL, USA.
authors.forename: M
authors.initials: M
authors.lastname: Jolly
authors.affiliation: 1 Department of Nursing, Graduate School of Medicine, Osaka University, Osaka, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Makimoto
mesh_terms: D000223:Adaptation, Psychological; D000328:Adult; D000367:Age Factors; D003431:Cross-Cultural Comparison; D005163:Factor Analysis, Statistical; D005260:Female; D006306:Health Surveys; D006801:Humans; D007564:Japan; D008180:Lupus Erythematosus, Systemic / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care / Q000379:methods*; D011788:Quality of Life; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires
keywords: Systemic lupus erythematosus; patient-reported outcomes; quality of life