title: Draft genome sequence of a GES-5-producing Serratia marcescens isolated in southern Brazil.
abstract: Serratia marcescens is a Gram-negative rod intrinsically resistant to polymyxins and usually associated with wound, respiratory and urinary tract infections. The whole genome of the first GES-5-producing S. marcescens isolated from a Brazilian patient was sequenced using Ion Torrent PGM System. Besides blaGES-5, we were able to identify genes encoding for other β-lactamases, for aminoglycoside modifying enzymes and for an efflux pump to tetracyclines.
authors.affiliation: Universidade Federal do Rio Grande do Sul, Programa de Pós-Graduação em Ciências Farmacêuticas, Porto Alegre, RS, Brazil; Hospital de Clínicas de Porto Alegre, Laboratório de Pesquisa em Resistência Bacteriana (LABRESIS), Porto Alegre, RS, Brazil. Electronic address: carol.nodari@gmail.com.
authors.forename: Carolina Silva
authors.initials: CS
authors.lastname: Nodari
authors.affiliation: Hospital de Clínicas de Porto Alegre, Unidade de Análises Moleculares e de Proteínas, Porto Alegre, RS, Brazil.
authors.forename: Marina
authors.initials: M
authors.lastname: Siebert
authors.affiliation: Hospital de Clínicas de Porto Alegre, Centro de Pesquisa Experimental, Porto Alegre, RS, Brazil; Universidade Federal do Rio Grande do Sul, Departamento de Genética, Porto Alegre, RS, Brazil.
authors.forename: Ursula da Silveira
authors.initials: UDS
authors.lastname: Matte
authors.affiliation: Universidade Federal do Rio Grande do Sul, Programa de Pós-Graduação em Ciências Farmacêuticas, Porto Alegre, RS, Brazil; Hospital de Clínicas de Porto Alegre, Laboratório de Pesquisa em Resistência Bacteriana (LABRESIS), Porto Alegre, RS, Brazil.
authors.forename: Afonso Luís
authors.initials: AL
authors.lastname: Barth
mesh_terms: D001938:Brazil; D004269:DNA, Bacterial / Q000737:chemistry* / Q000235:genetics*; D016680:Genome, Bacterial; D006801:Humans; D026901:Membrane Transport Proteins / Q000235:genetics; D017422:Sequence Analysis, DNA; D012706:Serratia marcescens / Q000201:enzymology* / Q000235:genetics* / Q000302:isolation & purification; D014166:Transferases / Q000378:metabolism; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism*
chemical_list: D004269:DNA, Bacterial; D026901:Membrane Transport Proteins; D014166:Transferases; D001618:beta-Lactamases
keywords: GES-5; Serratia marcescens; Whole-genome sequencing