title: Effects of delayed cord clamping on residual placental blood volume, hemoglobin and bilirubin levels in term infants: a randomized controlled trial.
abstract: The objective of the study was to measure the effects of a 5-min delay (DCC) versus immediate cord clamping (ICC) on residual placental blood volume (RPBV) at birth, and hemoglobin and serum bilirubin at 24 to 48 h of age.
  
  
  
  In this prospective randomized controlled trial, 73 women with term (37 to 41 weeks) singleton fetuses were randomized to DCC (⩾5 min; n=37) or ICC (<20 s; n=36).
  
  
  
  Maternal and infant demographics were not different between the groups. Mean cord clamping time was 303±121 (DCC) versus 23±59 (ICC) s (P<0.001) with 10 protocol violations. Cord milking was the proxy for DCC (n=11) when the provider could not wait. Infants randomized to DCC compared with ICC had significantly less RPBV (20.0 versus 30.8 ml kg-1, P<0.001), higher hemoglobin levels (19.4 versus 17.8 g dl-1, P=0.002) at 24 to 48 h, with no difference in bilirubin levels.
  
  
  
  Term infants had early hematological advantage of DCC without increases in hyperbilirubinemia or symptomatic polycythemia.
authors.affiliation: College of nursing, University of Rhode Island, Kingston, RI, USA.|Department of Pediatrics, Alpert School of Medicine, Brown University, Providence, RI, USA.|Department of Pediatrics, Women and Infants Hospital of Rhode Island, Providence, RI, USA.
authors.forename: J S
authors.initials: JS
authors.lastname: Mercer
authors.affiliation: College of nursing, University of Rhode Island, Kingston, RI, USA.|Department of Pediatrics, Women and Infants Hospital of Rhode Island, Providence, RI, USA.
authors.forename: D A
authors.initials: DA
authors.lastname: Erickson-Owens
authors.affiliation: Department of Pediatrics, Women and Infants Hospital of Rhode Island, Providence, RI, USA.
authors.forename: J
authors.initials: J
authors.lastname: Collins
authors.affiliation: Department of Pediatrics, Women and Infants Hospital of Rhode Island, Providence, RI, USA.
authors.forename: M O
authors.initials: MO
authors.lastname: Barcelos
authors.affiliation: Department of Pediatrics, Women and Infants Hospital of Rhode Island, Providence, RI, USA.
authors.forename: A B
authors.initials: AB
authors.lastname: Parker
authors.affiliation: Department of Pediatrics, Alpert School of Medicine, Brown University, Providence, RI, USA.|Department of Pediatrics, Women and Infants Hospital of Rhode Island, Providence, RI, USA.
authors.forename: J F
authors.initials: JF
authors.lastname: Padbury
mesh_terms: D000328:Adult; D001663:Bilirubin / Q000097:blood*; D001810:Blood Volume; D003250:Constriction; D036861:Delivery, Obstetric / Q000379:methods; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010920:Placenta / Q000098:blood supply; D021041:Placental Circulation; D011247:Pregnancy; D011446:Prospective Studies; D012237:Rhode Island; D047929:Term Birth / Q000097:blood*; D013997:Time Factors; D014470:Umbilical Cord / Q000098:blood supply*; D055815:Young Adult
chemical_list: D006454:Hemoglobins; D001663:Bilirubin