title: Comparative study between a spectral domain and a high-speed single-beam swept source OCTA system for identifying choroidal neovascularization in AMD.
abstract: This comparative study between a SD- and SS-OCTA system for visualizing neovascular patterns in AMD, also assessed the influence of cataract on OCTA imaging. 25 eyes with active CNV (AMD) were documented by FA, ICGA and SD-OCT. Two OCTA devices were used: A custom built SS-OCTA (1050 nm, 400,000 A-scans/s, 5 × 5 mm, no image segmentation); AngioVue (OptoVue, CA, USA) SD-OCTA (840 nm, 70.000 A-scans/s, 3 × 3 mm, SSADA technology). Two retina experts graded CNV types and vascular patterns. Cataract influence on OCTA image quality was reported for the superficial retinal plexus (6 eyes). The SS-OCTA prototype showed more CNV lesions compared to the SD-OCTA system (p = 0.01). Overall sensitivity of SD- and SS-OCTA systems to detect CNV lesions was.32 and.68, respectively. The SS-OCTA system was able to detect discrete lesion characteristics better than the SD-OCTA. No significant difference was found in the ability to identify CNV in treatment-naïve eyes. There was no significant influence of cataract. The SS-OCTA prototype detected CNV-associated vascular patterns more reliably than the SD-OCTA system. This is attributed to the SS-OCTA system's longer center wavelength and higher A-scan rate yielding higher definition and contrast of small neovascular structures. The SS-OCTA system used showed no advantage regarding cataract influence.
authors.affiliation: Department of Ophthalmology and Optometry, Vienna Clinical Trial Center (vCTC), Medical University of Vienna, Vienna, Austria.
authors.forename: R
authors.initials: R
authors.lastname: Told
authors.affiliation: Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria.|Christian Doppler Laboratory for Laser Development and their Application to Medicine and Biology, Center for Medical Physics and Biomedical Engineering, Medical University Vienna, Vienna, Austria.
authors.forename: L
authors.initials: L
authors.lastname: Ginner
authors.affiliation: Department of Ophthalmology and Optometry, Vienna Clinical Trial Center (vCTC), Medical University of Vienna, Vienna, Austria.
authors.forename: A
authors.initials: A
authors.lastname: Hecht
authors.affiliation: Department of Ophthalmology and Optometry, Vienna Clinical Trial Center (vCTC), Medical University of Vienna, Vienna, Austria.
authors.forename: S
authors.initials: S
authors.lastname: Sacu
authors.affiliation: Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria.|Christian Doppler Laboratory for Laser Development and their Application to Medicine and Biology, Center for Medical Physics and Biomedical Engineering, Medical University Vienna, Vienna, Austria.
authors.forename: R
authors.initials: R
authors.lastname: Leitgeb
authors.affiliation: Department of Ophthalmology and Optometry, Vienna Clinical Trial Center (vCTC), Medical University of Vienna, Vienna, Austria.
authors.forename: A
authors.initials: A
authors.lastname: Pollreisz
authors.affiliation: Department of Ophthalmology and Optometry, Vienna Clinical Trial Center (vCTC), Medical University of Vienna, Vienna, Austria.
authors.forename: U
authors.initials: U
authors.lastname: Schmidt-Erfurth
mesh_terms: D000368:Aged; D002386:Cataract / Q000473:pathology; D002829:Choroid / Q000473:pathology*; D020256:Choroidal Neovascularization / Q000473:pathology*; D005260:Female; D005451:Fluorescein Angiography / Q000379:methods; D006801:Humans; D008297:Male; D011446:Prospective Studies; D012160:Retina / Q000473:pathology*; D041623:Tomography, Optical Coherence / Q000379:methods