title: Exosomes as miRNA Carriers: Formation-Function-Future.
abstract: Exosomes, which are one of the smallest extracellular vesicles released from cells, have been shown to carry different nucleic acids, including microRNAs (miRNAs). miRNAs significantly regulate cell growth and metabolism by posttranscriptional inhibition of gene expression. The rapidly changing understanding of exosomes' formation and function in delivering miRNAs from cell to cell has prompted us to review current knowledge in exosomal miRNA secretion mechanisms as well as possible therapeutic applications for personalized medicine.
authors.affiliation: Institute for Pathology, University Hospital of Cologne, 50924 Cologne, Germany. xiaojie.yu@uk-koeln.de.|Center for Molecular Medicine Cologne, University of Cologne, 50924 Cologne, Germany. xiaojie.yu@uk-koeln.de.
authors.forename: Xiaojie
authors.initials: X
authors.lastname: Yu
authors.affiliation: Institute for Pathology, University Hospital of Cologne, 50924 Cologne, Germany. m.odenthal@uni-koeln.de.|Center for Molecular Medicine Cologne, University of Cologne, 50924 Cologne, Germany. m.odenthal@uni-koeln.de.
authors.forename: Margarete
authors.initials: M
authors.lastname: Odenthal
authors.affiliation: Institute for Pathology, University Hospital of Cologne, 50924 Cologne, Germany. jochen.fries@uni-koeln.de.
authors.forename: Jochen W U
authors.initials: JW
authors.lastname: Fries
mesh_terms: D000818:Animals; D055354:Exosomes / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000378:metabolism; D035683:MicroRNAs / Q000378:metabolism*; D008954:Models, Biological; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics
chemical_list: D035683:MicroRNAs
keywords: cell metabolism; exosome; extracellular vesicle; miRNA