title: The role of 18F-fluorodeoxyglucose positron emission tomography in the assessment of disease activity of adult-onset Still's disease.
abstract: OBJECTIVE
  18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) has been suggested as a reliable imaging technique for monitoring of disease activity in patients with adult-onset Still's disease (AOSD). Therefore, we investigated the clinical significance of 18F-FDG PET/CT in Korean AOSD patients.
  
  
  METHODS
  Thirteen AOSD patients were included in the study. The PET/CT images were evaluated with visual and semiquantitative method using standardized uptake values (SUVs).
  
  
  RESULTS
  The presence of increased 18F-FDG uptake was noted in 90% of clinically active AOSD patients. 18F-FDG uptake was located in the lymph node, spleen, and bone marrow. Visual grade and SUV intensity of lymph node was significantly correlated with the systemic score of AOSD. Visual grade of spleen was significantly correlated with the systemic score, erythrocyte sedimentation rate (ESR), and ferritin. Additionally, visual grade and SUV intensity of bone marrow was significantly correlated with the systemic score, ESR, leukocyte, and neutrophil.
  
  
  CONCLUSIONS
  Visual grade and SUV intensity of lymph node, spleen, and bone marrow on 18F-FDG PET/CT scan showed significant correlations with known disease activity markers. The data suggest that 18F-FDG PET/CT scan may be a useful imaging technique for evaluation of disease activity in AOSD patients.
authors.affiliation: Department of Nuclear Medicine and Molecular Imaging, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Young-Sil
authors.initials: YS
authors.lastname: An
authors.affiliation: Department of Rheumatology, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Chang-Hee
authors.initials: CH
authors.lastname: Suh
authors.affiliation: Department of Rheumatology, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Ju-Yang
authors.initials: JY
authors.lastname: Jung
authors.affiliation: Department of Rheumatology, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Hundo
authors.initials: H
authors.lastname: Cho
authors.affiliation: Department of Rheumatology, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Hyoun-Ah
authors.initials: HA
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D012189:Retrospective Studies; D016706:Still's Disease, Adult-Onset / Q000000981:diagnostic imaging*; D055815:Young Adult
chemical_list: D019788:Fluorodeoxyglucose F18
keywords: 18F-fluorodeoxyglucose positron emission tomography/computed tomography; Disease activity; Still’s disease, adult-onset