title: Whole-Inactivated and Virus-Like Particle Vaccine Strategies for Chikungunya Virus.
abstract: Chikungunya virus (CHIKV) is a global public health threat, having been identified in >60 countries in Asia, Africa, Europe, and the Americas. There is no cure for or licensed vaccine against CHIKV infection. Initial attempts at CHIKV vaccine development began in the early 1960s. Whole-inactivated and virus-like particle (VLP) vaccines are 2 of the current approaches being evaluated. Success of these approaches is dependent on a safe, well-tolerated vaccine that is immunogenic and deployable in regard to manufacturing, stability, and delivery characteristics.
authors.affiliation: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
authors.forename: Adam D
authors.initials: AD
authors.lastname: DeZure
authors.affiliation: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
authors.forename: Nina M
authors.initials: NM
authors.lastname: Berkowitz
authors.affiliation: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
authors.forename: Barney S
authors.initials: BS
authors.lastname: Graham
authors.affiliation: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
authors.forename: Julie E
authors.initials: JE
authors.lastname: Ledgerwood
mesh_terms: D000349:Africa / Q000453:epidemiology; D000569:Americas / Q000453:epidemiology; D000818:Animals; D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D001208:Asia / Q000453:epidemiology; D065632:Chikungunya Fever / Q000453:epidemiology / Q000276:immunology* / Q000517:prevention & control* / Q000821:virology; D002646:Chikungunya virus / Q000276:immunology*; D017321:Clinical Trials, Phase I as Topic; D017322:Clinical Trials, Phase II as Topic; D005060:Europe / Q000453:epidemiology; D006801:Humans; D015164:Vaccines, Inactivated / Q000276:immunology; D058425:Vaccines, Virus-Like Particle / Q000276:immunology*; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D015164:Vaccines, Inactivated; D058425:Vaccines, Virus-Like Particle; D014765:Viral Vaccines
keywords: alphavirus; chikungunya virus; vaccine; virus-like particle vaccine; whole-inactivated vaccine