title: Canstatin induces apoptosis in gastric cancer xenograft growth in mice through the mitochondrial apoptotic pathway.
abstract: Canstatin, the non-collagenous domain of collagen type IV α-chains, belongs to a series of collagen-derived angiogenic inhibitors. In this study, the inhibitory effect of recombinant canstatin on tumour growth was investigated using a gastric cancer xenograft model. The volume and weight of tumours in mice treated with canstatin were lower than that in mice treated with PBS. Accordingly, the survival rate of these mice was significantly higher than that of mice bearing tumours treated with PBS. Moreover, valuable insight into the mechanisms mediated by canstatin was obtained.
authors.affiliation: Department of Surgical Oncology, First Affiliated Hospital of China Medical University, Shenyang 110001, China.
authors.forename: Ya-Nan
authors.initials: YN
authors.lastname: Xing
authors.affiliation: Department of Surgical Oncology, First Affiliated Hospital of China Medical University, Shenyang 110001, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Deng
authors.affiliation: Department of Surgical Oncology, First Affiliated Hospital of China Medical University, Shenyang 110001, China cmu_directorHM@163.com.
authors.forename: Hui-Mian
authors.initials: HM
authors.lastname: Xu
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D002642:Chick Embryo; D024141:Collagen Type IV / Q000494:pharmacology*; D064593:Heterografts; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D008928:Mitochondria / Q000378:metabolism* / Q000473:pathology; D009368:Neoplasm Transplantation; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D023041:Xenograft Model Antitumor Assays
chemical_list: C502625:COL4A2 protein, human; D024141:Collagen Type IV
keywords: canstatin; chick chorioallantoic membrane; gastric cancer; mitochondrial apoptotic pathway; survival rate