title: Regenerative Endodontics by Cell Homing.
abstract: Apical revascularization (AR) and platelet-rich plasma have been used to restore dental pulp vitality in infected immature permanent teeth. Two regenerative therapies are cell transplantation and cell homing. This article updates and benchmarks these therapies with cell homing. A case report concluded that AR increased root length; however, quantitative and statistical assessments disproved this. Regenerative endodontic therapies require prospective clinical trials demonstrating safety and efficacy. These therapies are intrinsically susceptible to procedural and patient variations. Cell homing uses novel molecules that drive therapeutic efficacy, and may be less sensitive to procedural and patient variations.
authors.affiliation: Division of Endodontics, Center for Craniofacial Regeneration, Columbia University Medical Center, Columbia University, 630 West 168 Street, New York, NY 10032, USA; Department of Operative Dentistry and Endodontics, Guanghua School of Stomatology, Hospital of Stomatology, Guangdong Province Key Laboratory of Stomatology, Sun Yat-sen University, 56 Lingyuan West Road, Guangzhou, Guangdong, 510055, China.
authors.forename: Ling
authors.initials: L
authors.lastname: He
authors.affiliation: Division of Endodontics, Center for Craniofacial Regeneration, Columbia University Medical Center, Columbia University, 630 West 168 Street, New York, NY 10032, USA.
authors.forename: Juan
authors.initials: J
authors.lastname: Zhong
authors.affiliation: Division of Endodontics, Center for Craniofacial Regeneration, Columbia University Medical Center, Columbia University, 630 West 168 Street, New York, NY 10032, USA; Department of Operative Dentistry and Endodontics, Guanghua School of Stomatology, Hospital of Stomatology, Guangdong Province Key Laboratory of Stomatology, Sun Yat-sen University, 56 Lingyuan West Road, Guangzhou, Guangdong, 510055, China.
authors.forename: Qimei
authors.initials: Q
authors.lastname: Gong
authors.affiliation: Department of Biostatistics, Columbia University Mailman School of Public Health, 722 West 168th Street, Room 631, New York, NY 10032, USA. Electronic address: bc2159@cumc.columbia.edu.
authors.forename: Bin
authors.initials: B
authors.lastname: Cheng
authors.affiliation: Division of Endodontics, Center for Craniofacial Regeneration, Columbia University Medical Center, College of Dental Medicine, Columbia University, 630 West 168 Street - PH7Stem #128, New York, NY 10032, USA. Electronic address: sgk2114@columbia.edu.
authors.forename: Sahng G
authors.initials: SG
authors.lastname: Kim
authors.affiliation: Department of Operative Dentistry and Endodontics, Guanghua School of Stomatology, Hospital of Stomatology, Guangdong Province Key Laboratory of Stomatology, Sun Yat-sen University, 56 Lingyuan West Road, Guangzhou, Guangdong, 510055, China. Electronic address: lingjunqi@163.com.
authors.forename: Junqi
authors.initials: J
authors.lastname: Ling
authors.affiliation: Department of Operative Dentistry and Endodontics, Guanghua School of Stomatology, Hospital of Stomatology, Guangdong Province Key Laboratory of Stomatology, Sun Yat-sen University, 56 Lingyuan West Road, Guangzhou, Guangdong, 510055, China; Division of Endodontics, Center for Craniofacial Regeneration, Columbia University Medical Center, Columbia University, 630 West 168 Street - PH7E, New York, NY 10032, USA. Electronic address: jmao@columbia.edu.
authors.forename: Jeremy J
authors.initials: JJ
authors.lastname: Mao
mesh_terms: D000818:Animals; D002465:Cell Movement; D017690:Cell Transplantation; D003782:Dental Pulp / Q000502:physiology*; D003790:Dental Pulp Necrosis / Q000628:therapy*; D006801:Humans; D012038:Regeneration; D023822:Tissue Engineering; D054457:Tissue Scaffolds
keywords: Cell homing; Dental pulp; Dentin; Endodontics; Regeneration; Regenerative; Tissue engineering