title: Impact of weight loss on oxidative stress and inflammatory cytokines in obese type 2 diabetic patients.
abstract: BACKGROUND
  Type 2 diabetes mellitus is associated with abnormal markers of inflammatory cytokines and oxidative stress markers. Although, these abnormalities could be modulated with weight reduction; there is limitation in clinical studies that have addressed the beneficial effects of weight reduction in modulating biomarkers of inflammatory cytokines and oxidative stress for obesity associated with type 2 diabetes mellitus.
  
  
  OBJECTIVE
  This study was designed to detect the effects of weight loss on the inflammatory cytokines, oxidative stress markers in obese type 2 diabetic patients.
  
  
  METHODS
  Eighty obese patients with type 2 diabetes mellitus, their age ranged from 35-57 years and their body mass index ranged from 31-35 kg/m2were equally assigned into 2 groups: the weight reduction group received aerobic exercises, diet regimen, where as the control group received medical treatment only for 12 weeks.
  
  
  RESULTS
  The mean values of body mass index (BMI), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), C-reactive protein (sCRP), conjugated dienes (CD) and malondialdehyde (MDA) were significantly decreased, while the mean values of glutathione peroxidase (GPx), superoxide dismutase (SOD) and glutathione (GSH) were significantly increased in patients of group (A), while changes were not significant in group (B). Also, there were significant differences between mean levels of the investigated parameters in group (A) and group (B) at the end of the study.
  
  
  CONCLUSIONS
  Weight loss ameliorates inflammatory cytokines and oxidative stress markers in obese type 2 diabetic patients.
authors.affiliation: Department of Physical Therapy, Faculty of Applied Medical Sciences, King Abdulaziz University.
authors.forename: Shehab M
authors.initials: SM
authors.lastname: Abd El-Kader
authors.affiliation: Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University.
authors.forename: Mohammed H
authors.initials: MH
authors.lastname: Saiem Al-Dahr
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000032:analysis*; D016207:Cytokines / Q000276:immunology*; D003924:Diabetes Mellitus, Type 2; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity; D018384:Oxidative Stress / Q000276:immunology*; D015431:Weight Loss / Q000276:immunology*
chemical_list: D016207:Cytokines; D002097:C-Reactive Protein
keywords: Type 2 diabetes; cytokines; obesity; oxidative stress; weight reduction