title: The molecular basis of metabolic cycles and their relationship to circadian rhythms.
abstract: Metabolic cycles result from the partitioning of oxidative and reductive metabolism into rhythmic phases of gene expression and oscillating post-translational protein modifications. Relatively little is known about how these switches in gene expression are controlled, although recent studies have suggested that transcription itself may play a central role. This review explores the molecular basis of the metabolic and gene-expression oscillations in the yeast Saccharomyces cerevisiae, as well as how they relate to other biological time-keeping mechanisms, such as circadian rhythms.
authors.affiliation: Department of Biochemistry, University of Oxford, Oxford, UK.
authors.forename: Jane
authors.identifier: http://orcid.org/0000-0002-5196-3734
authors.initials: J
authors.lastname: Mellor
mesh_terms: D000818:Animals; D002940:Circadian Rhythm; D015966:Gene Expression Regulation, Fungal; D006801:Humans; D053858:Metabolic Networks and Pathways; D010507:Periodicity; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000235:genetics* / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics* / Q000378:metabolism*; D015533:Transcriptional Activation; D000071218:Ultradian Rhythm
chemical_list: D029701:Saccharomyces cerevisiae Proteins