title: Fluorescence and drug loading properties of ZnSe:Mn/ZnS-Paclitaxel/SiO2nanocapsules templated by F127 micelles.
abstract: Hydrophobic ZnSe:Mn/ZnS core-shell fluorescence quantum dots (QDs) and anticancer drug paclitaxel (PTX) have been co-loaded into folate conjugated hybrid silica nanocapsules via F127 micelles based soft-template method in a mild aqueous environment at room temperature. The encapsulation of QDs shows a F127: QDs mass ratio dependent behavior, which impact much on the morphology and optical properties of composite nanocapsules. These as prepared composite nanocapsules also exhibit good photoluminescence stability under the temperature ranges from 19°C to 49°C. In addition, the aqueous solubility of PTX (0.1μg/mL) can be efficiently enhanced about 630 times to 62.99μg/mL, and the loaded PTX could be released during 12h sustainably. These tunable fluorescence, enhanced drug loading efficiency and sustained release behavior manifest that the hybrid nanocapsule is a promising theranostic nanoplatform for future combined fluorescence imaging and chemotherapy.
authors.affiliation: Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials - Hubei Key Laboratory of Ferro & Piezoelectric Materials and Devices, Faculty of Physics & Electronic Sciences, Hubei University, Wuhan 430062, PR China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Zhao
authors.affiliation: Faculty of Life Sciences, Hubei University, Wuhan 430062, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.affiliation: Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials - Hubei Key Laboratory of Ferro & Piezoelectric Materials and Devices, Faculty of Physics & Electronic Sciences, Hubei University, Wuhan 430062, PR China. Electronic address: ybli@hubu.edu.cn.
authors.forename: Yuebin
authors.initials: Y
authors.lastname: Li
authors.affiliation: Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials - Hubei Key Laboratory of Ferro & Piezoelectric Materials and Devices, Faculty of Physics & Electronic Sciences, Hubei University, Wuhan 430062, PR China.
authors.forename: Mingguang
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials - Hubei Key Laboratory of Ferro & Piezoelectric Materials and Devices, Faculty of Physics & Electronic Sciences, Hubei University, Wuhan 430062, PR China.
authors.forename: Jian
authors.initials: J
authors.lastname: He
authors.affiliation: Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials - Hubei Key Laboratory of Ferro & Piezoelectric Materials and Devices, Faculty of Physics & Electronic Sciences, Hubei University, Wuhan 430062, PR China.
authors.forename: Xuewen
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials - Hubei Key Laboratory of Ferro & Piezoelectric Materials and Devices, Faculty of Physics & Electronic Sciences, Hubei University, Wuhan 430062, PR China.
authors.forename: Hui
authors.initials: H
authors.lastname: Liu
authors.affiliation: Faculty of Life Sciences, Hubei University, Wuhan 430062, China.
authors.forename: Xingguo
authors.initials: X
authors.lastname: Wang
authors.affiliation: Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials - Hubei Key Laboratory of Ferro & Piezoelectric Materials and Devices, Faculty of Physics & Electronic Sciences, Hubei University, Wuhan 430062, PR China. Electronic address: guhsh@hubu.edu.cn.
authors.forename: Haoshuang
authors.initials: H
authors.lastname: Gu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage* / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000737:chemistry; D065546:Drug Liberation; D005453:Fluorescence; D008345:Manganese / Q000737:chemistry*; D008823:Micelles; D053769:Nanocapsules / Q000737:chemistry; D017239:Paclitaxel / Q000008:administration & dosage* / Q000737:chemistry; D011095:Polyethylenes / Q000737:chemistry*; D011126:Polypropylenes / Q000737:chemistry*; D045663:Quantum Dots / Q000737:chemistry* / Q000648:ultrastructure; D018036:Selenium Compounds / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry; D013440:Sulfides / Q000737:chemistry*; D017967:Zinc Compounds / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D003692:Delayed-Action Preparations; D008823:Micelles; D053769:Nanocapsules; D011095:Polyethylenes; D011126:Polypropylenes; D018036:Selenium Compounds; D013440:Sulfides; D017967:Zinc Compounds; D008345:Manganese; D012822:Silicon Dioxide; C078661:UCON 50-HB-5100; C031238:zinc sulfide; C044696:zinc selenide; D017239:Paclitaxel
keywords: Drug loading and release; Fluorescence; Hybrid nanocapsules; Soft-template assembly