title: Long QT Syndrome and Duodenal Ampullary Adenoma: A New Association.
abstract: KCNQ1gene mutation has a well-known association with long QT syndrome (LQTS). However, recent studies suggest that it may be implicated in intestinal neoplasia. We present a 27-year-old Hispanic man with a known history of LQTS secondary toKCNQ1mutation, who presented with painless jaundice. Endoscopic retrograde pancreatic cholangiography revealed a prominent ampulla, with histology consistent with ampullary adenoma with high-grade dysplasia. Further endoscopic studies did not suggest familial adenomatous polyposis. To date, this is the index case of duodenal ampullary adenoma in the setting ofKCNQ1mutation.
authors.affiliation: Department of Internal Medicine, Florida Hospital, Orlando, FL.
authors.forename: F N U
authors.initials: FN
authors.lastname: Asad-Ur-Rahman
authors.affiliation: Department of Internal Medicine, Florida Hospital, Orlando, FL.
authors.forename: Laura
authors.initials: L
authors.lastname: Hughes
authors.affiliation: Khyber Medical College, Peshawar, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Talha Khan
authors.affiliation: Center for Interventional Endoscopy, Florida Hospital, Orlando, FL.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Khalid Hasan
authors.affiliation: Central Florida Gastroenterology and Hepatology, Florida Hospital, Orlando, FL.
authors.forename: Irteza
authors.initials: I
authors.lastname: Inayat