title: Catalytic Diverse Radical-Mediated 1,2-Cyanofunctionalization of Unactivated Alkenes via Synergistic Remote Cyano Migration and Protected Strategies.
abstract: A catalytic radical protocol for 1,2-cyanofunctionalization of unactivated alkenes involving remote cyano migration triggered by addition of diverse carbon- and heteroatom-centered radicals to alkenes has been developed. This powerful strategy provides a diverse platform for the collection of a variety of synthetically important β-functionalized alkyl nitriles bearing densely functionalized carbonyl, cyano, and other various functional groups within the same molecules. The substrates TMS (trimethylsilyl)-protected alkenyl cyanohydrins are straightforwardly accessible via simple cyanosilylation of the corresponding ketones.
authors.affiliation: College of Materials Science & Engineering, Key Laboratory of Interface Science and Engineering in Advanced Materials, Ministry of Education, Taiyuan University of Technology , Shanxi, 030024, China.|Department of Chemistry, South University of Science and Technology of China , Shenzhen, 518055, China.
authors.forename: Na
authors.initials: N
authors.lastname: Wang
authors.affiliation: Department of Chemistry, South University of Science and Technology of China , Shenzhen, 518055, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Chemistry, South University of Science and Technology of China , Shenzhen, 518055, China.
authors.forename: Zhong-Liang
authors.initials: ZL
authors.lastname: Li
authors.affiliation: Department of Chemistry, South University of Science and Technology of China , Shenzhen, 518055, China.
authors.forename: Ning-Yuan
authors.initials: NY
authors.lastname: Yang
authors.affiliation: College of Materials Science & Engineering, Key Laboratory of Interface Science and Engineering in Advanced Materials, Ministry of Education, Taiyuan University of Technology , Shanxi, 030024, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Guo
authors.affiliation: College of Materials Science & Engineering, Key Laboratory of Interface Science and Engineering in Advanced Materials, Ministry of Education, Taiyuan University of Technology , Shanxi, 030024, China.
authors.forename: Hong-Xia
authors.initials: HX
authors.lastname: Zhang
authors.affiliation: Department of Chemistry, South University of Science and Technology of China , Shenzhen, 518055, China.
authors.forename: Xin-Yuan
authors.initials: XY
authors.lastname: Liu