title: Synthesis and Cytotoxicity of Dendritic Platinum Nanoparticles with HEK-293 Cells.
abstract: Dendritic platinum nanoparticles (DPNs) have been synthesized from l-ascorbic acid and an amphiphilic non-ionic surfactant (Brij-58) via a sonochemical method. The particle size and shape of the DPNs could be tuned by changing the reduction temperature, resulting in a uniform DPN with a size of 23 nm or 60 nm. The facets of DPNs have been studied by high-resolution transmission electron microscopy. The cytotoxicity of DPNs has been investigated using human embryonic kidney cells (HEK-293), and the biological adaptability exhibited by DPNs has opened a pathway to biomedical applications such as drug-delivery systems, photothermal treatment, and biosensors.
authors.affiliation: Institute for Superconducting & Electronic Materials (ISEM), Australian Institute for Innovative Materials (AIIM), University of Wollongong, North Wollongong, NSW 2500, Australia.
authors.forename: Kyubin
authors.initials: K
authors.lastname: Shim
authors.affiliation: Institute for Superconducting & Electronic Materials (ISEM), Australian Institute for Innovative Materials (AIIM), University of Wollongong, North Wollongong, NSW 2500, Australia.
authors.forename: Jeonghun
authors.initials: J
authors.lastname: Kim
authors.affiliation: Graduate Institute of Ferrous Technology (GIFT), Pohang University of Science and Technology (POSTECH), San 31, Hyoja-Dong, Pohang, 790-784, Republic of Korea.
authors.forename: Yoon-Uk
authors.initials: YU
authors.lastname: Heo
authors.affiliation: International Center for Materials Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki, 305-0044, Japan.
authors.forename: Bo
authors.initials: B
authors.lastname: Jiang
authors.affiliation: International Center for Materials Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki, 305-0044, Japan.
authors.forename: Cuiling
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Physics and Astronomy, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Shahabuddin
authors.affiliation: Division of Medical Engineering Research, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County, 350, Taiwan.
authors.forename: Kevin C-W
authors.initials: KC
authors.lastname: Wu
authors.affiliation: Institute for Superconducting & Electronic Materials (ISEM), Australian Institute for Innovative Materials (AIIM), University of Wollongong, North Wollongong, NSW 2500, Australia.
authors.forename: Md Shahriar A
authors.initials: MS
authors.lastname: Hossain
authors.affiliation: Institute for Superconducting & Electronic Materials (ISEM), Australian Institute for Innovative Materials (AIIM), University of Wollongong, North Wollongong, NSW 2500, Australia.|International Center for Materials Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki, 305-0044, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Yamauchi
authors.affiliation: Institute for Superconducting & Electronic Materials (ISEM), Australian Institute for Innovative Materials (AIIM), University of Wollongong, North Wollongong, NSW 2500, Australia.
authors.forename: Jung Ho
authors.initials: JH
authors.lastname: Kim
mesh_terms: D001205:Ascorbic Acid / Q000737:chemistry; D015374:Biosensing Techniques; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D050091:Dendrimers / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D016503:Drug Delivery Systems; D057809:HEK293 Cells; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D010789:Phototherapy; D010984:Platinum / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013499:Surface Properties; D013501:Surface-Active Agents / Q000737:chemistry
chemical_list: D050091:Dendrimers; D013501:Surface-Active Agents; D010984:Platinum; D001205:Ascorbic Acid
keywords: biocompatibility; cytotoxicity; nanoparticles; nanoporous materials; platinum