title: 11C-Acetate-PET/CT Compared to 99mTc-HDP Bone Scintigraphy in Primary Staging of High-risk Prostate Cancer.
abstract: The aim of this study was to evaluate the detection rate of bone metastases and the added value of11C-acetate (ACE) positron-emission tomography/computed tomography (PET/CT) compared to bone scintigraphy (BS) in high-risk prostate cancer (PC).
  
  
  
  A total of 66 untreated patients with high-risk PC with ACE-PET/CT and planar BS findings within 3 months of each other were retrospectively enrolled. Findings were compared and verified with follow-up data after an average of 26 months.
  
  
  
  The rate of detection of bone metastases was superior with ACE-PET/CT compared to BS (p<0.01). Agreement between the methods and between BS and follow-up was moderate (Cohen's kappa coefficient of 0.64 and 0.66, respectively). Agreement between ACE-PET/CT and follow-up was excellent (kappa coefficient of 0.95). Therapy was changed in 11% of patients due to ACE-PET/CT results.
  
  
  
  ACE-PET/CT performed better than planar BS in detection of bone metastases in high-risk PC. ACE-PET/CT findings influenced clinical management.
authors.affiliation: Department of Radiation Sciences, Umea University, Umea, Sweden Sara.strandberg@vll.se.
authors.forename: Sara
authors.initials: S
authors.lastname: Strandberg
authors.affiliation: Department of Radiation Sciences, Umea University, Umea, Sweden.
authors.forename: Camilla Thellenberg
authors.initials: CT
authors.lastname: Karlsson
authors.affiliation: Department of Radiation Sciences, Umea University, Umea, Sweden.
authors.forename: Mattias
authors.initials: M
authors.lastname: Ogren
authors.affiliation: Department of Radiation Sciences, Umea University, Umea, Sweden.
authors.forename: Jan
authors.initials: J
authors.lastname: Axelsson
authors.affiliation: Department of Radiation Sciences, Umea University, Umea, Sweden.
authors.forename: Katrine
authors.initials: K
authors.lastname: Riklund
mesh_terms: D000085:Acetates / Q000008:administration & dosage*; D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D009367:Neoplasm Staging; D015609:Organotechnetium Compounds / Q000008:administration & dosage*; D049268:Positron-Emission Tomography; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging*; D012307:Risk Factors; D014057:Tomography, X-Ray Computed
chemical_list: D000085:Acetates; D015609:Organotechnetium Compounds
keywords: PET/CT; Prostate cancer; [11C]-acetate; bone metastasis; bone scintigraphy