title: [Diagnosis of Idiopathic Inflammatory Myopathy: A Muscle Pathology Perspective].
abstract: Idiopathic inflammatory myopathies are historically classified into polymyositis and dermatomyositis based on the presence or absence of skin lesions. Recently, however, a more histology-oriented classification into 6 subtypes has been proposed. The subtypes include dermatomyositis, polymyositis, inclusion body myositis, immune-mediated necrotizing myopathy, anti-synthetase syndrome, and non-specific myositis. With strict criteria applied, polymyositis is now extremely rare, while immune-mediated necrotizing myopathy is the most common among all inflammatory myopathies and is often associated with autoantibodies including those for signal recognition particle (SRP) or 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR).
authors.affiliation: Department of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry.
authors.forename: Michio
authors.initials: M
authors.lastname: Inoue
authors.forename: Ichizo
authors.initials: I
authors.lastname: Nishino
mesh_terms: D000906:Antibodies / Q000276:immunology; D006801:Humans; D009220:Myositis / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology*
chemical_list: D000906:Antibodies