title: Improved Detection of Minimal Residual Disease by 11C-Methionine PET/CT in a Young Patient With Unusual Extramedullary Presentation of Recurrent Multiple Myeloma.
abstract: Extramedullary relapse of multiple myeloma (MM) is uncommon. A 40-year-old woman with history of MM underwent PET/CT using C-methionine (C-MET) after the detection of a vulvar lesion on MRI, biopsy proven to be extramedullary relapse of MM. The vulvar lesion was negative at the F-FDG PET/CT but showed high uptake of C-MET; focal uptake of both F-FDG and C-MET was shown within the muscles of the left leg, histologically confirmed as extramedullary relapse of MM. F-FDG PET/CT performed after chemotherapy showed no uptake in both sites, whereas posttreatment C-MET PET/CT showed persistence of residual uptake within the vulvar lesion.
authors.affiliation: From the Institutes of *Nuclear Medicine, and †Hematology, Università Cattolica del Sacro Cuore, Rome, Italy.
authors.forename: Carmelo
authors.initials: C
authors.lastname: Caldarella
authors.forename: Salvatore
authors.initials: S
authors.lastname: Annunziata
authors.forename: Livio
authors.initials: L
authors.lastname: Pagano
authors.forename: Valerio
authors.initials: V
authors.lastname: De Stefano
authors.forename: Vittoria
authors.initials: V
authors.lastname: Rufini
mesh_terms: D000328:Adult; D002250:Carbon Radioisotopes; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008715:Methionine; D009101:Multiple Myeloma / Q000000981:diagnostic imaging* / Q000473:pathology; D019042:Muscle Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging*; D000072078:Positron Emission Tomography Computed Tomography; D019275:Radiopharmaceuticals
chemical_list: D002250:Carbon Radioisotopes; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D008715:Methionine