title: Genetic Environment of the blaKPC-2 Gene in a Klebsiella pneumoniae Isolate That May Have Been Imported to Russia from Southeast Asia.
abstract: The nucleotide sequence of a blaKPC-2-harboring plasmid (pKPCAPSS) from Klebsiella pneumoniae ST273 isolated in Saint Petersburg, Russia, from a patient with history of recent travel to Vietnam is presented. This 127,970-bp plasmid possessed both IncFII and IncR replicons. blaKPC-2was localized on a hypothetical mobile element. This element was flanked by 38-bp inverted Tn3 repeats and included a Tn3-specific transposase gene, macrolide resistance operon (mphA-mrx-mphR), and a fragment of blaTEMwith unique polymorphisms.
authors.affiliation: Scientific Research Institute of Children's Infections, Saint Petersburg, Russia.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Ageevets
authors.affiliation: Saint Petersburg Branch of Vavilov Institute of General Genetics, Saint Petersburg, Russia.|Saint Petersburg State University, Saint Petersburg, Russia.
authors.forename: Julia
authors.initials: J
authors.lastname: Sopova
authors.affiliation: Scientific Research Institute of Children's Infections, Saint Petersburg, Russia.
authors.forename: Irina
authors.initials: I
authors.lastname: Lazareva
authors.affiliation: Research Institute for Physical-Chemical Medicine, Moscow, Russia.
authors.forename: Maya
authors.initials: M
authors.lastname: Malakhova
authors.affiliation: Research Institute for Physical-Chemical Medicine, Moscow, Russia.
authors.forename: Elena
authors.initials: E
authors.lastname: Ilina
authors.affiliation: Research Institute for Physical-Chemical Medicine, Moscow, Russia.
authors.forename: Elena
authors.initials: E
authors.lastname: Kostryukova
authors.affiliation: Research Institute for Physical-Chemical Medicine, Moscow, Russia.
authors.forename: Vladislav
authors.identifier: 0000-0003-2242-2127
authors.initials: V
authors.lastname: Babenko
authors.affiliation: Istituto Superiore di Sanità, Rome, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Carattoli
authors.affiliation: Scientific Research Institute of Children's Infections, Saint Petersburg, Russia.|North-Western State Medical University named after I. I. Mechnikov, Saint Petersburg, Russia.
authors.forename: Yuri
authors.initials: Y
authors.lastname: Lobzin
authors.affiliation: Scientific Research Institute of Children's Infections, Saint Petersburg, Russia.
authors.forename: Alexander
authors.initials: A
authors.lastname: Uskov
authors.affiliation: Scientific Research Institute of Children's Infections, Saint Petersburg, Russia sidorserg@gmail.com.|North-Western State Medical University named after I. I. Mechnikov, Saint Petersburg, Russia.
authors.forename: Sergey
authors.identifier: 0000-0003-3550-7875
authors.initials: S
authors.lastname: Sidorenko
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001210:Asia, Southeastern; D024881:Drug Resistance, Bacterial / Q000187:drug effects / Q000235:genetics; D006801:Humans; D007710:Klebsiella Infections / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D018942:Macrolides / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009876:Operon; D010957:Plasmids / Q000235:genetics*; D012426:Russia; D019895:Transposases / Q000235:genetics; D014744:Vietnam; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides; D019895:Transposases; D001618:beta-Lactamases; C547585:beta-lactamase KPC-2, Klebsiella pneumoniae
keywords: IncFII; IncR; KPC-2; Klebsiella pneumoniae; transposons