title: Recent Advances and Challenges in Studies of Control of Cancer Stem Cells and the Gut Microbiome by the Trametes-Derived Polysaccharopeptide PSP (Review).
abstract: The medicinal mushroom Trametes versicolor has been well recognized for its activity in maintaining the general health of the population and in managing and treating human diseases in various cultures. Its use has been recently gaining acceptance and popularity in Western countries. The reported health benefits of T. versicolor led to a search for the identity of its bioactive ingredients. These efforts have resulted in the isolation of the polysaccharopeptide PSP from cultured mycelia of strain Cov-1, which expresses large amounts of PSP. The availability of highly purified PSP was followed by studies of its biological activities using tissue culture models and limited human clinical trials. In this review we summarize recent advances in the antitumorigenic and immunomodulatory effects of PSP, elimination of prostate cancer stem cells and control of the intestinal microbiome, and its interplay with host cells as a prebiotic. These findings may have implications for widening and repurposing the use of PSP.
authors.affiliation: Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY.
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Wu
authors.affiliation: Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY.
authors.forename: Barbara B
authors.initials: BB
authors.lastname: Doonan
authors.affiliation: Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY.
authors.forename: Tze-Chen
authors.initials: TC
authors.lastname: Hsieh
authors.affiliation: Institute of Microbiology and Immunology, Shanghai Normal University, Shanghai, People's Republic of China.
authors.forename: Qingyao
authors.initials: Q
authors.lastname: Yang
authors.affiliation: Institute of Microbiology and Immunology, Shanghai Normal University; and Department of Pathology, the University of Hong Kong, R.P. China.
authors.forename: Xiao-Tong
authors.initials: XT
authors.lastname: Yang
authors.affiliation: Laboratory of Cancer Therapeutic Development, Australian Prostate Cancer Research Centre, Queensland University of Technology, Queensland, Australia.
authors.forename: Ming-Tat
authors.initials: MT
authors.lastname: Ling
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D000069196:Gastrointestinal Microbiome / Q000187:drug effects*; D006801:Humans; D014411:Neoplastic Stem Cells / Q000187:drug effects*; D011509:Proteoglycans / Q000737:chemistry / Q000494:pharmacology*; D055454:Trametes / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D011509:Proteoglycans; C093216:polysaccharide peptide