title: Synthesis of NH-sulfoximines from sulfides by chemoselective one-pot N- and O-transfers.
abstract: Direct synthesis of NH-sulfoximines from sulfides has been achieved through O and NH transfer in the same reaction, occurring with complete selectivity. The reaction is mediated by bisacetoxyiodobenzene under simple conditions and employs inexpensive N-sources. Preliminary studies indicate that NH-transfer is likely to be first, followed by oxidation, but the reaction proceeds successfully in either order. A wide range of functional groups and biologically relevant compounds are tolerated. The use of AcO15NH4affords15N-labeled compounds.
authors.affiliation: Department of Pharmacy - Drug Sciences, University of Bari, "A. Moro" Via E. Orabona 4, Bari 70125, Italy. renzo.luisi@uniba.it.
authors.forename: Arianna
authors.initials: A
authors.lastname: Tota
authors.affiliation: Department of Pharmacy - Drug Sciences, University of Bari, "A. Moro" Via E. Orabona 4, Bari 70125, Italy. renzo.luisi@uniba.it.
authors.forename: Marina
authors.initials: M
authors.lastname: Zenzola
authors.affiliation: Department of Chemistry, Imperial College London, South Kensington, London SW7 2AZ, UK. j.bull@imperial.ac.uk.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Chawner
authors.affiliation: Department of Chemistry, Imperial College London, South Kensington, London SW7 2AZ, UK. j.bull@imperial.ac.uk.
authors.forename: Sahra St
authors.initials: SS
authors.lastname: John-Campbell
authors.affiliation: Department of Pharmacy - Drug Sciences, University of Bari, "A. Moro" Via E. Orabona 4, Bari 70125, Italy. renzo.luisi@uniba.it.
authors.forename: Claudia
authors.initials: C
authors.lastname: Carlucci
authors.affiliation: DICATECh, Politecnico di Bari, Via E. Orabona 4, Bari 70125, Italy and CNR NANOTEC-Istituto di Nanotecnologia, Campus Ecotekne, via Monteroni, 73100 Lecce, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Romanazzi
authors.affiliation: Department of Pharmacy - Drug Sciences, University of Bari, "A. Moro" Via E. Orabona 4, Bari 70125, Italy. renzo.luisi@uniba.it.
authors.forename: Leonardo
authors.initials: L
authors.lastname: Degennaro
authors.affiliation: Department of Chemistry, Imperial College London, South Kensington, London SW7 2AZ, UK. j.bull@imperial.ac.uk.
authors.forename: James A
authors.identifier: 0000-0003-3993-5818
authors.initials: JA
authors.lastname: Bull
authors.affiliation: Department of Pharmacy - Drug Sciences, University of Bari, "A. Moro" Via E. Orabona 4, Bari 70125, Italy. renzo.luisi@uniba.it.
authors.forename: Renzo
authors.identifier: 0000-0002-9882-7908
authors.initials: R
authors.lastname: Luisi