title: Garmultins A-G, Biogenetically Related Polycyclic Acylphloroglucinols from Garcinia multiflora.
abstract: Garmultins A and B (1 and 2), two polycyclic polyprenylated acylphloroglucinols characterized by the coupling of two novel cages, 2,11-dioxatricyclo[4.4.1.03,9]undecane and tricyclo[4.3.1.03,7]decane, along with five biogenetically related analogues (3-7), were isolated from Garcinia multiflora. Their structures and absolute configurations were determined by extensive NMR analysis, X-ray crystallography, and electronic circular dichroism calculations. Three compounds were capable of inhibiting oncogene expression and inducing apoptosis in human erythroleukemia cells.
authors.affiliation: The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences , Guiyang 550002, P. R. China.|Guizhou University , Guiyang 550025, P. R. China.
authors.forename: Dong Song
authors.initials: DS
authors.lastname: Tian
authors.affiliation: The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences , Guiyang 550002, P. R. China.
authors.forename: Ping
authors.initials: P
authors.lastname: Yi
authors.affiliation: The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences , Guiyang 550002, P. R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Xia
authors.affiliation: Guizhou University , Guiyang 550025, P. R. China.
authors.forename: Xin
authors.initials: X
authors.lastname: Xiao
authors.affiliation: The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences , Guiyang 550002, P. R. China.
authors.forename: Yi Min
authors.initials: YM
authors.lastname: Fan
authors.affiliation: The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences , Guiyang 550002, P. R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Gu
authors.affiliation: The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences , Guiyang 550002, P. R. China.
authors.forename: Lie Jun
authors.initials: LJ
authors.lastname: Huang
authors.affiliation: The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences , Guiyang 550002, P. R. China.
authors.forename: Yaacov
authors.initials: Y
authors.lastname: Ben-David
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, P. R. China.
authors.forename: Ying Tong
authors.initials: YT
authors.lastname: Di
authors.affiliation: The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences , Guiyang 550002, P. R. China.
authors.forename: Chun Mao
authors.initials: CM
authors.lastname: Yuan
authors.affiliation: The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences , Guiyang 550002, P. R. China.|State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, P. R. China.
authors.forename: Xiao Jiang
authors.initials: XJ
authors.lastname: Hao
mesh_terms: D000072283:A549 Cells; D000215:Acylation; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D029760:Garcinia / Q000737:chemistry* / Q000235:genetics; D018922:HL-60 Cells; D006801:Humans; D061986:MCF-7 Cells; D015394:Molecular Structure; D010696:Phloroglucinol / Q000302:isolation & purification* / Q000494:pharmacology; D011084:Polycyclic Aromatic Hydrocarbons / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D011084:Polycyclic Aromatic Hydrocarbons; D010696:Phloroglucinol