title: Asthma phenotypes in children and stratified pharmacological treatment regimens.
abstract: Asthma is the most common inflammatory disease in childhood. The interaction of genetic, environmental and host factors may contribute to the development of childhood asthma and defines its progress, including persistence and severity. Until now, various classifications of childhood asthma phenotypes have been suggested based on patient's age during onset of symptoms, type of inflammatory cells, response to treatment and disease severity. Many efforts have been carried out to identify childhood asthma phenotypes and to clarify which are the risk factors that define asthma prediction and the response to therapy. The identification of asthma phenotypes has not only prognostic but also therapeutic role. However, the classification of asthma phenotypes is complex due to the heterogeneity of the disease. Areas covered: The current childhood asthma phenotypes and the new therapeutic strategies for each phenotype are reviewed. Expert commentary: There are multiple phenotypes in childhood asthma and it is crucial to define them before the initiation of personalized treatment. Both the therapeutic strategy and monitoring should follow the recent guidelines.
authors.affiliation: a Paediatric Respiratory Unit, Department of Pediatrics , University Hospital of Alexandroupolis , Alexandroupolis , Greece.
authors.forename: Maria
authors.initials: M
authors.lastname: Iordanidou
authors.affiliation: b 2nd Respiratory Medicine Department , National and Kapodistrian University of Athens Medical School, Attiko University Hospital , Athens , Greece.
authors.forename: Stelios
authors.initials: S
authors.lastname: Loukides
authors.affiliation: a Paediatric Respiratory Unit, Department of Pediatrics , University Hospital of Alexandroupolis , Alexandroupolis , Greece.
authors.forename: Emmanouil
authors.initials: E
authors.lastname: Paraskakis
mesh_terms: D018927:Anti-Asthmatic Agents / Q000627:therapeutic use*; D001249:Asthma / Q000145:classification* / Q000188:drug therapy / Q000503:physiopathology; D002648:Child; D006801:Humans; D010641:Phenotype; D057285:Precision Medicine / Q000379:methods; D011379:Prognosis; D012307:Risk Factors; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D018927:Anti-Asthmatic Agents
keywords: Childhood asthma phenotypes; asthma endotypes; asthma monitoring; personalized treatment; wheezing