title: Radial Spokes-A Snapshot of the Motility Regulation, Assembly, and Evolution of Cilia and Flagella.
abstract: Propulsive forces generated by cilia and flagella are used in events that are critical for the thriving of diverse eukaryotic organisms in their environments. Despite distinctive strokes and regulations, the majority of them adopt the 9+2 axoneme that is believed to exist in the last eukaryotic common ancestor. Only a few outliers have opted for a simpler format that forsakes the signature radial spokes and the central pair apparatus, although both are unnecessary for force generation or rhythmicity. Extensive evidence has shown that they operate as an integral system for motility control. Recent studies have made remarkable progress on the radial spoke. This review will trace how the new structural, compositional, and evolutional insights pose significant implications on flagella biology and, conversely, ciliopathy.
authors.affiliation: The Department of Biological Sciences, Marquette University, Milwaukee, Wisconsin 53201.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Zhu
authors.affiliation: The Department of Biological Sciences, Marquette University, Milwaukee, Wisconsin 53201.
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.affiliation: The Department of Biological Sciences, Marquette University, Milwaukee, Wisconsin 53201.
authors.forename: Pinfen
authors.initials: P
authors.lastname: Yang
mesh_terms: D000818:Animals; D005075:Biological Evolution; D002465:Cell Movement / Q000502:physiology*; D002923:Cilia / Q000502:physiology*; D005407:Flagella / Q000502:physiology*; D006801:Humans; D008870:Microtubules / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism
chemical_list: D009419:Nerve Tissue Proteins