title: S100P is Overexpressed in Squamous Cell and Adenosquamous Carcinoma Subtypes of Endometrial Cancer and Promotes Cancer Cell Proliferation and Invasion.
abstract: S100P is known to affect tumor development and metastasis of various cancers, but its role in endometrial cancer is unclear. We reported that S100P expression was dramatically elevated in both endometrial squamous cell carcinoma and adenosquamous carcinoma, but not in adenocarcinoma and normal endometrial samples. Moreover, we revealed an oncogenic role of S100P promoting cell proliferation, invasion, and migration while reducing apoptosis, possibly via its upregulation and/or activation of receptors of advanced glycation end products and consequently the oncogenic PI3K-AKT and MAPK pathways. Therefore, S100P might be a specific biomarker and a potential drug target for squamous cell and adenosquamous carcinoma subtypes of endometrial cancer.
authors.affiliation: a Assisted Reproduction Unit, Department of Obstetrics and Gynecology , Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University , Hangzhou , China.
authors.forename: Hongfei
authors.initials: H
authors.lastname: Jiang
authors.affiliation: a Assisted Reproduction Unit, Department of Obstetrics and Gynecology , Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University , Hangzhou , China.
authors.forename: Hang
authors.initials: H
authors.lastname: Hu
authors.affiliation: b Department of Biochemistry , Yong Loo Lin School of Medicine, National University of Singapore , Singapore.
authors.forename: Fan
authors.initials: F
authors.lastname: Lin
authors.affiliation: b Department of Biochemistry , Yong Loo Lin School of Medicine, National University of Singapore , Singapore.
authors.forename: Yoon Pin
authors.initials: YP
authors.lastname: Lim
authors.affiliation: c College of Pharmaceutical Science, Zhejiang University of Technology , Hangzhou , China.
authors.forename: Yunfen
authors.initials: Y
authors.lastname: Hua
authors.affiliation: a Assisted Reproduction Unit, Department of Obstetrics and Gynecology , Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University , Hangzhou , China.
authors.forename: Xiaomei
authors.initials: X
authors.lastname: Tong
authors.affiliation: a Assisted Reproduction Unit, Department of Obstetrics and Gynecology , Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University , Hangzhou , China.
authors.forename: Songying
authors.initials: S
authors.lastname: Zhang
mesh_terms: D017209:Apoptosis / Q000187:drug effects / Q000235:genetics; D014408:Biomarkers, Tumor; D002135:Calcium-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D018196:Carcinoma, Adenosquamous / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D002453:Cell Cycle / Q000187:drug effects / Q000235:genetics; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D002470:Cell Survival / Q000187:drug effects; D002945:Cisplatin / Q000494:pharmacology; D016889:Endometrial Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D005260:Female; D015870:Gene Expression; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009363:Neoplasm Proteins / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction; D014162:Transfection
chemical_list: D014408:Biomarkers, Tumor; D002135:Calcium-Binding Proteins; D009363:Neoplasm Proteins; C103003:S100P protein, human; D002945:Cisplatin
keywords: Cancer biomarkers; other gynecological tumors; tumor cell biology