title: Highly expressed lncRNA CCND2-AS1 promotes glioma cell proliferation through Wnt/β-catenin signaling.
abstract: Glioma is the most common and aggressive primary brain tumor in adults. Long-non coding RNAs (lncRNAs) have been recently shown to play important roles in regulating numerous biological processes both in physiologic and pathologic condition. However, the role of lncRNAs in glioma remains largely unknown. In this study, we firstly found that lncRNA CCND2-AS2 is significantly up regulated in malignant glioma tissues and cell lines. Both loss- and gain-functions assays show that CCND2-AS1 promotes glioma cells proliferation and growth. In addition, we also revealed that highly expressed CCND2-AS1 could enhance Wnt/β-catenin signaling in glioma. Taken together, our findings revealed a novel lncRNA CCND2-AS1 promotes glioma cell proliferation through Wnt/β-catenin signaling and CCND2-AS1 might function as a potential novel therapeutic target for the treatment of glioma.
authors.affiliation: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Endocrinology, Taian City Central Hospital, Taian, China.
authors.forename: Dai-Lin
authors.initials: DL
authors.lastname: Wei
authors.affiliation: Department of Oncology, Taian City Central Hospital, Taian, China.
authors.forename: Long
authors.initials: L
authors.lastname: Wan
authors.affiliation: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
authors.forename: Shao-Feng
authors.initials: SF
authors.lastname: Yan
authors.affiliation: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. Electronic address: pekingtiantan@126.com.
authors.forename: Yan-Hui
authors.initials: YH
authors.lastname: Sun
mesh_terms: D001253:Astrocytes / Q000378:metabolism; D001932:Brain Neoplasms / Q000378:metabolism*; D002453:Cell Cycle; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D056742:Cyclin D2 / Q000378:metabolism*; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D005910:Glioma / Q000378:metabolism*; D006801:Humans; D011379:Prognosis; D062085:RNA, Long Noncoding / Q000235:genetics*; D014162:Transfection; D015854:Up-Regulation; D060449:Wnt Signaling Pathway
chemical_list: C080336:CCND2 protein, human; D056742:Cyclin D2; D062085:RNA, Long Noncoding
keywords: Glioma; LncRNA CCND2-AS1; Wnt/β-catenin signaling