title: A RecQ Protein-like 5 Haplotype is Associated With Colon Cancer.
abstract: BACKGROUND
  Emerging murine model data suggests RecQ protein-like 5 (RECQL5) is a tumor suppressor gene. The goal of our study was to test whetherRECQL5gene variants are associated with colon cancer susceptibility.
  
  
  METHODS
  We examined the association of two haplotype-tagging SNPs inRECQL5and colon cancer in a population-based study of 390 colon cancer cases and 464 population controls.
  
  
  RESULTS
  While both crude and covariate-adjusted single SNP analyses were only suggestive for an association with borderline significance (p = 0.07), haplotype analysis shows that individuals carrying the T-G haplotype (rs820196 common allele and rs4789223 minor allele) were at significantly increased risk for colon cancer (OR = 1.34, 95% CI = 1.02-1.76, p = 0.05). Adjustment for age, sex, body mass index, non-steroidal anti-inflammatory use and family history of colon cancer did not alter the results.
  
  
  CONCLUSIONS
  These results suggest that a haplotype harboring the minor allele of rs4789223 is associated with colon cancer risk. Further study ofRECQL5as a colon cancer susceptibility gene is warranted, particularly with respect to variants in linkage disequilibrium with rs4789223.
authors.affiliation: Department of Social and Preventive Medicine, State University of New York at Buffalo, Buffalo, New York, 14214, USA; Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, 44106, USA.
authors.forename: Heather M
authors.initials: HM
authors.lastname: Ochs-Balcom
authors.affiliation: Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, 44106, USA; Department of Family Medicine, Case Western Reserve University/University Hospitals Case Medical Center, Cleveland, Ohio, 44106, USA; Case Center for Transdisciplinary Research on Energetics and Cancer, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, 44106, USA.
authors.forename: Cheryl
authors.initials: C
authors.lastname: L Thompson
authors.affiliation: Department of Preventive Medicine, University of Southern California, Los Angeles, California, 90089, USA.
authors.forename: Sarah
authors.initials: S
authors.lastname: Plummer
authors.affiliation: Department of Genetics, Case Western Reserve University, 44106, Cleveland, Ohio, USA.
authors.forename: Guangbin
authors.initials: G
authors.lastname: Luo
authors.affiliation: Cancer Control Program, University of Kentucky, Lexington, Kentucky, 40536, USA.
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Tucker
authors.affiliation: Department of Preventive Medicine, University of Southern California, Los Angeles, California, 90089, USA.
authors.forename: Graham
authors.initials: G
authors.lastname: Casey
authors.affiliation: Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, 44106, USA; Department of Family Medicine, Case Western Reserve University/University Hospitals Case Medical Center, Cleveland, Ohio, 44106, USA; Case Center for Transdisciplinary Research on Energetics and Cancer, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, 44106, USA.
authors.forename: Li
authors.initials: L
authors.lastname: Li
keywords: Colon cancer; Haplotype; RECQL5; Single Nucleotide Polymorphism