title: Survival and Control Prognosticators of Recurrent Gynecological Malignancies of the Pelvis and Para-aortic Region Treated with Stereotactic Body Radiation Therapy.
abstract: OBJECTIVE
  To define prognostic factors associated with improved survival and local control (LC) for gynecologic cancer recurrences limited to the pelvis and para-aortic (PA) region using stereotactic body radiation therapy (SBRT).
  
  
  METHODS
  Between 2/2008 and 7/2014, 30 women (35 targets) with pelvic or PA recurrence of endometrioid (n= 12), cervical (n= 11), ovarian (n= 3), uterine-serous (n= 2), or carcinosarcoma (n= 2) cancer were treated with SBRT. Eleven recurrences were located in the central pelvis, 11 along the pelvic sidewall (PSW), and 13 in the PA region.
  
  
  RESULTS
  Five-year survival for all patients was 42% with a median survival of 43.4 months. Multivariate analysis revealed better performance status (PS), and smaller clinical tumor volume was significant for improved survival (p< 0.05).
  
  
  CONCLUSIONS
  SBRT is a local therapy for recurrent gynecological malignancies in the pelvis and PA region with curative potential. SBRT is especially effective for LC when targeting PSW or PA recurrence and for patients with a cervical/endometrioid uterine primary. Survival is improved for patients with better PS and smaller recurrence volume prior to SBRT.
authors.affiliation: Radiation Oncology, Philadelphia Cyberknife, Crozer-Keystone Healthcare System , Havertown, PA , USA.
authors.forename: Shaakir
authors.initials: S
authors.lastname: Hasan
authors.affiliation: Radiation Oncology, Philadelphia Cyberknife, Crozer-Keystone Healthcare System , Havertown, PA , USA.
authors.forename: Anthony
authors.initials: A
authors.lastname: Ricco
authors.affiliation: Radiation Oncology, Philadelphia Cyberknife, Crozer-Keystone Healthcare System , Havertown, PA , USA.
authors.forename: Kaylette
authors.initials: K
authors.lastname: Jenkins
authors.affiliation: Radiation Oncology, Philadelphia Cyberknife, Crozer-Keystone Healthcare System , Havertown, PA , USA.
authors.forename: Rachelle
authors.initials: R
authors.lastname: Lanciano
authors.affiliation: University of Pennsylvania School of Nursing , Philadelphia, PA , USA.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Hanlon
authors.affiliation: Radiation Oncology, Philadelphia Cyberknife, Crozer-Keystone Healthcare System , Havertown, PA , USA.
authors.forename: John
authors.initials: J
authors.lastname: Lamond
authors.affiliation: Radiation Oncology, Philadelphia Cyberknife, Crozer-Keystone Healthcare System , Havertown, PA , USA.
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
authors.affiliation: Radiation Oncology, Philadelphia Cyberknife, Crozer-Keystone Healthcare System , Havertown, PA , USA.
authors.forename: Jing
authors.initials: J
authors.lastname: Feng
authors.affiliation: Radiation Oncology, Philadelphia Cyberknife, Crozer-Keystone Healthcare System , Havertown, PA , USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Good
authors.affiliation: Radiation Oncology, Philadelphia Cyberknife, Crozer-Keystone Healthcare System , Havertown, PA , USA.
authors.forename: Joel
authors.initials: J
authors.lastname: Noumoff
authors.affiliation: Radiation Oncology, Philadelphia Cyberknife, Crozer-Keystone Healthcare System , Havertown, PA , USA.
authors.forename: Luther
authors.initials: L
authors.lastname: Brady
keywords: endometrial neoplasms; gynecological malignancies; ovarian neoplasms; stereotactic body radiation therapy; uterine cervical neoplasms; uterine neoplasms