title: Reply to Constance et al.
authors.affiliation: Servicio de Hematologia y Grupo 44 IIS-IP, Hospital Universitario de la Princesa, Madrid, Spain.
authors.forename: J L
authors.initials: JL
authors.lastname: Steegmann
authors.affiliation: Department of Hematology and Oncology 'L. and A. Seràgnoli', St Orsola University Hospital, Bologna, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Baccarani
authors.affiliation: Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK.
authors.forename: R E
authors.initials: RE
authors.lastname: Clark