title: Validation of the Pancreatic Donor Risk Index in Simultaneous Pancreas-Kidney Transplantation Performed in Córdoba Hospital From 2000 to 2015.
abstract: BACKGROUND
  The Pancreatic Donor Risk Index (PDRI) was developed in 2010 in the United States to predict graft survival after pancreas transplantation, based on donor characteristics and logistical and technical conditions. The aim of the study was to validate the utility of PDRI as a pancreas allograft survival predictor in simultaneous pancreas-kidney transplantation (SPK) transplants performed in our hospital between 2000 and 2015.
  
  
  METHODS
  This retrospective analysis of 126 SPK transplants was performed by the same surgical team from the years 2000 to 2015. Donor variables that are integrated in the PDRI were calculated (age, sex, race, creatinine serum levels, body mass index, height, cold ischemia time, cause of death, type of pancreas transplant). Pancreatic graft survival at 1 and 5 years was calculated by use of the Kaplan-Meier test. Comparison of survival curves between PDRI risk quartiles was calculated by use of the log-rank test. Association between graft survival and variables integrating the PDRI was calculated by use of univariate Cox regression analysis.
  
  
  RESULTS
  Log-rank analysis found no statistically significant association between global graft survival and PDRI quartiles. Univariate Cox regression analysis showed a statistically significant association between graft survival and cold ischemia time (P < .05).
  
  
  CONCLUSIONS
  PDRI was not a useful tool to predict pancreatic graft outcomes in a Spanish reference population.
authors.affiliation: Department of Urology, University Hospital Reina Sofía, Córdoba, Spain. Electronic address: juanjo.salamanca.bustos@gmail.com.
authors.forename: J J
authors.initials: JJ
authors.lastname: Salamanca-Bustos
authors.affiliation: Department of Urology, University Hospital Reina Sofía, Córdoba, Spain.
authors.forename: J P
authors.initials: JP
authors.lastname: Campos-Hernandez
authors.affiliation: Department of Surgery, University Hospital Reina Sofía, Córdoba, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Sánchez-Hidalgo
authors.affiliation: Department of Surgery, University Hospital Reina Sofía, Córdoba, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Arjona-Sánchez
authors.affiliation: Department of Urology, University Hospital Reina Sofía, Córdoba, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Sánchez-González
authors.affiliation: Department of Urology, University Hospital Reina Sofía, Córdoba, Spain.
authors.forename: A J
authors.initials: AJ
authors.lastname: Arenas-Bonilla
authors.affiliation: Department of Surgery, University Hospital Reina Sofía, Córdoba, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Ruiz-Rabelo
authors.affiliation: Department of Urology, University Hospital Reina Sofía, Córdoba, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Carrasco-Valiente
authors.affiliation: Department of Urology, University Hospital Reina Sofía, Córdoba, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Ruiz-García
authors.affiliation: Department of Urology, University Hospital Reina Sofía, Córdoba, Spain.
authors.forename: J C
authors.initials: JC
authors.lastname: Regueiro-López
authors.affiliation: Department of Surgery, University Hospital Reina Sofía, Córdoba, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Briceño-Delgado
authors.affiliation: Department of Urology, University Hospital Reina Sofía, Córdoba, Spain.
authors.forename: M J
authors.initials: MJ
authors.lastname: Requena-Tapia
mesh_terms: D000328:Adult; D005260:Female; D006085:Graft Survival / Q000502:physiology; D006761:Hospitals / Q000706:statistics & numerical data; D006801:Humans; D053208:Kaplan-Meier Estimate; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000379:methods / Q000401:mortality; D008297:Male; D016035:Pancreas Transplantation / Q000009:adverse effects* / Q000379:methods / Q000401:mortality; D012044:Regression Analysis; D012189:Retrospective Studies; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D014019:Tissue Donors / Q000706:statistics & numerical data*; D014481:United States; D055815:Young Adult