title: Comparison of the Characteristics and Performance of Flurbiprofen 8.75 mg Spray for Sore Throat.
abstract: BACKGROUND
  Sore throat sprays provide targeted relief by delivering the active ingredient directly to the site of pain. Different sprays vary in characteristics, thus affecting delivery of the active ingredient to the throat, which can impact compliance.
  
  
  OBJECTIVE
  The characteristics and performance of FLURBIPROFEN 8.75 mg SPRAY were compared with 12 other sprays.
  
  
  METHODS
  Parameters assessed included spray angle and pattern, droplet size distribution, shot weight uniformity and shot weight throughout life.
  
  
  RESULTS
  Among all sprays tested WICK Sulagil Halsspray had the smallest spray angle (46°) and also the smallest diameter spray pattern (X=32.8 mm; Y=34.4 mm). Thiovalone® Buccal Spray Suspension had both the largest spray angle (82°) and largest diameter spray pattern (X=62.6 mm; Y=78.0 mm). Hasco Sept® Aerosol Spray had the smallest droplet size (Dv90=118.4 μm) whereas OKi infiammazione e dolore® 0.16% spray had the largest (Dv90=214.34 μm). In terms of shot weight uniformity, TANTUM® VERDE GOLA 0.25% spray showed the least variation (2% RSD) between shots and UNIBEN Aerosol Spray the most (23.4% RSD). Shot weight throughout life studies showed that FLURBIPROFEN 8.75 mg SPRAY had the least deviation from shot weight (1.77%) whereas OKi infiammazione e dolore® 0.16% spray deviated the most (44.9%). FLURBIPROFEN 8.75 mg SPRAY had the second smallest spray angle/pattern and droplet size distribution and also the least variation in shot weight.
  
  
  CONCLUSIONS
  Different sore throat sprays vary in different attributes, affecting delivery of the active ingredient. FLURBIPROFEN 8.75 mg SPRAY performed well overall, ranking first among all sprays tested, and providing a dose which is targeted and uniformly delivered throughout the life of the bottle.
authors.affiliation: Reckitt Benckiser (Brands) Ltd, Hull, United Kingdom.
authors.forename: David
authors.initials: D
authors.lastname: Veale
authors.affiliation: Reckitt Benckiser (Brands) Ltd, Hull, United Kingdom.
authors.forename: Adrian
authors.initials: A
authors.lastname: Shephard
authors.affiliation: Reckitt Benckiser (Brands) Ltd, Hull, United Kingdom.
authors.forename: Verity
authors.initials: V
authors.lastname: Adams
authors.affiliation: Reckitt Benckiser (Brands) Ltd, Hull, United Kingdom.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Lidster
mesh_terms: D000284:Administration, Oral; D000336:Aerosols; D000700:Analgesics / Q000008:administration & dosage*; D005480:Flurbiprofen / Q000008:administration & dosage*
chemical_list: D000336:Aerosols; D000700:Analgesics; D005480:Flurbiprofen
keywords: Droplet size; drug delivery; flurbiprofen; oral spray; pharyngitis; spray angle; spray pattern