title: Isolation of novel stilbenoids from the roots of Cyrtopodium paniculatum (Orchidaceae).
abstract: Four new stilbenoids, named cyrtopodinone (1), cyrtopodinol (2), and coeludols A and B (3-4) were isolated from the roots of Cyrtopodium paniculatum, together with 21 known stilbenoids derivatives (5-25). Their structures were elucidated by comprehensive spectroscopic analysis including extensive 1D and 2D-NMR techniques. The cytotoxic activities of the isolated compounds were tested on human glioblastoma U-87MG cell line with fluorescence-based image cytometry. Only four compounds (18, 19, 22 and 25) displayed moderate cytotoxicity with IC50values of 45.2, 39.9, 58.2 and 48.0μM, respectively.
authors.affiliation: Laboratory of Pharmacognosy and Bioactive Natural Products, Faculty of Pharmacy, Strasbourg University, 67400 Illkirch-Graffenstaden, France. Electronic address: florence.auberon@gmail.com.
authors.forename: Florence
authors.initials: F
authors.lastname: Auberon
authors.affiliation: Laboratory of Pharmacognosy and Bioactive Natural Products, Faculty of Pharmacy, Strasbourg University, 67400 Illkirch-Graffenstaden, France.
authors.forename: Opeyemi Joshua
authors.initials: OJ
authors.lastname: Olatunji
authors.affiliation: Laboratory of Pharmacognosy and Bioactive Natural Products, Faculty of Pharmacy, Strasbourg University, 67400 Illkirch-Graffenstaden, France.
authors.forename: Diamondra
authors.initials: D
authors.lastname: Raminoson
authors.affiliation: Institut Pluridisciplinaire Hubert Curien, UMR 7178 CNRS, Strasbourg University, 67401 Illkirch-Graffenstaden, France.
authors.forename: Christian D
authors.initials: CD
authors.lastname: Muller
authors.affiliation: LVMH Recherche, 45800 Saint Jean de Braye, France.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Soengas
authors.affiliation: LVMH Recherche, 45800 Saint Jean de Braye, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Bonté
authors.affiliation: Laboratory of Pharmacognosy and Bioactive Natural Products, Faculty of Pharmacy, Strasbourg University, 67400 Illkirch-Graffenstaden, France.
authors.forename: Annelise
authors.initials: A
authors.lastname: Lobstein
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D029595:Orchidaceae / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry*; D013267:Stilbenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D013267:Stilbenes
keywords: Cyrtopodium paniculatum; Human glioblastoma; Orchidaceae; Phenanthrene dimers; Phenanthrenes; Stilbenoids