title: Robust Colloidal Nanoparticles of Pyrrolopyrrole Cyanine J-Aggregates with Bright Near-Infrared Fluorescence in Aqueous Media: From Spectral Tailoring to Bioimaging Applications.
abstract: Colloidal nanoparticles (NPs) containing near-infrared-fluorescent J-aggregates (JAGGs) of pyrrolopyrrole cyanines (PPcys) stabilized by amphiphilic block co-polymers were prepared in aqueous medium. JAGG formation can be tuned by means of the chemical structure of PPcys, the concentration of chromophores inside the polymeric NPs, and ultrasonication. The JAGG NPs exhibit a narrow emission band at 773 nm, a fluorescence quantum yield comparable to that of indocyanine green, and significantly enhanced photostability, which is ideal for long-term bioimaging.
authors.affiliation: School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore, 637459, Singapore.
authors.forename: Cangjie
authors.initials: C
authors.lastname: Yang
authors.affiliation: School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore, 637459, Singapore.|Present address: National Center for Nano Science and Technology, Zhongguancun Beiyitiao, Beijing, 100190, P. R. China.
authors.forename: Xiaochen
authors.initials: X
authors.lastname: Wang
authors.affiliation: School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore, 637459, Singapore.
authors.forename: Mingfeng
authors.initials: M
authors.lastname: Wang
authors.affiliation: School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore, 637459, Singapore.
authors.forename: Keming
authors.initials: K
authors.lastname: Xu
authors.affiliation: School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore, 637459, Singapore.|NTU-Northwestern Institute for Nanomedicine, Nanyang Technological University, 50 Nanyang Avenue, Singapore, 639798, Singapore.
authors.forename: Chenjie
authors.initials: C
authors.lastname: Xu
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003102:Colloids / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D053758:Nanoparticles / Q000737:chemistry* / Q000633:toxicity; D009369:Neoplasms / Q000000981:diagnostic imaging; D011108:Polymers / Q000737:chemistry; D011758:Pyrroles / Q000737:chemistry*; D013010:Sonication; D013053:Spectrophotometry; D019265:Spectroscopy, Near-Infrared; D014183:Transplantation, Heterologous; D014867:Water / Q000737:chemistry
chemical_list: D003102:Colloids; D005456:Fluorescent Dyes; D011108:Polymers; D011758:Pyrroles; D014867:Water
keywords: aggregation; colloids; fluorescence; imaging agents; nanoparticles