title: Focus on the role of Caveolin and Cavin protein families in liposarcoma.
abstract: The identification of ancillary biomarkers useful to improve diagnosis is a major challenge for adipocytic liposarcoma (LPS), the most common type among soft tissue sarcomas affecting adulthood. Recent findings have reported the expression of some proteins belonging to Caveolin and Cavin families as a critical hallmark distinctive of the least aggressive, well-differentiated LPS tumors. These proteins are involved in the biogenesis, morphology and function of caveolae, minute bulb-shaped domains of the plasma membrane that play a crucial role in the adipose tissue by controlling hormone-dependent uptake of nutrients and contributing to the maintenance of tissue integrity. In light of this, in this paper we covered different topics, including metabolism, hypoxia and cell mechanoprotection, to outline the rationale for considering a deeper investigation of Caveolin and Cavin protein members in LPS neoplasms as an opportunity to identify pro-differentiating mechanisms that could counteract tumor growth.
authors.affiliation: Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Codenotti
authors.affiliation: Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy.
authors.forename: Marika
authors.initials: M
authors.lastname: Vezzoli
authors.affiliation: Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy.
authors.forename: Eugenio
authors.initials: E
authors.lastname: Monti
authors.affiliation: Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy. Electronic address: alessandro.fanzani@unibs.it.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Fanzani
mesh_terms: D000273:Adipose Tissue / Q000254:growth & development / Q000473:pathology; D014408:Biomarkers, Tumor / Q000235:genetics*; D021941:Caveolae / Q000378:metabolism / Q000473:pathology; D051242:Caveolin 1 / Q000235:genetics*; D002454:Cell Differentiation / Q000235:genetics; D002462:Cell Membrane / Q000235:genetics / Q000473:pathology; D006801:Humans; D008080:Liposarcoma / Q000235:genetics* / Q000473:pathology; D016601:RNA-Binding Proteins / Q000235:genetics*
chemical_list: D014408:Biomarkers, Tumor; C497835:CAVIN1 protein, human; D051242:Caveolin 1; D016601:RNA-Binding Proteins
keywords: Adipocytes; Caveolae; Caveolins; Cavins; Liposarcoma; Metabolism