title: Borinic Acid Catalysed Reduction of Tertiary Amides with Hydrosilanes: A Mild and Chemoselective Synthesis of Amines.
abstract: A reduction of various aryl, alkyl, and α,β-unsaturated amides with phenylsilane, catalysed by a borinic acid, is reported. The unprecedented reaction was carried out under very mild conditions and led to useful amines. Furthermore, the reaction tolerates a variety of functional groups. Initial investigations implicated that an intermediate diarylhydroborane is involved in the reaction mechanism.
authors.affiliation: Normandie Univ., ENSICAEN, UNICAEN, CNRS, LCMT, 14000, Caen, France.
authors.forename: Aurélien
authors.initials: A
authors.lastname: Chardon
authors.affiliation: Normandie Univ., ENSICAEN, UNICAEN, CNRS, LCMT, 14000, Caen, France.
authors.forename: Tharwat
authors.initials: T
authors.lastname: Mohy El Dine
authors.affiliation: Normandie Univ., ENSICAEN, UNICAEN, CNRS, LCMT, 14000, Caen, France.
authors.forename: Rémi
authors.initials: R
authors.lastname: Legay
authors.affiliation: COBRA, IRCOF, CNRS UMR 6014 & FR 3038, Université de Rouen et INSA de Rouen, 7682, Mt. St. Aignan, France.
authors.forename: Michaël
authors.initials: M
authors.lastname: De Paolis
authors.affiliation: Normandie Univ., ENSICAEN, UNICAEN, CNRS, LCMT, 14000, Caen, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Rouden
authors.affiliation: Normandie Univ., ENSICAEN, UNICAEN, CNRS, LCMT, 14000, Caen, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Blanchet
keywords: amides; amines; borinic acid; organocatalysis; reduction