title: Randomised comparison of drug-eluting versus bare-metal stenting in patients with non-ST elevation myocardial infarction.
abstract: The superiority of drug-eluting stents (DES) over bare-metal stents (BMS) in patients with ST elevation myocardial infarction (STEMI) is well studied; however, randomised data in patients with non-ST elevation myocardial infarction (NSTEMI) are lacking. The objective of this study was to investigate whether stenting with everolimus-eluting stents (EES) safely reduces restenosis in patients with NSTEMI as compared to BMS.
  
  
  
  ELISA-3 patients were asked to participate in the angiographic substudy and were randomised to DE (Xience V) or BM (Vision) stenting (ELISA-3 group). The primary end point was minimal luminal diameter (MLD) at 9-month follow-up angiography. In addition, 296 patients with NSTEMI who were excluded or did not want to participate in the ELISA-3 trial (RELI group) were randomised to DE or BM stenting and underwent clinical follow-up only (major adverse cardiac events (MACE), stent thrombosis (ST)). A pooled analysis was performed to assess an effect on clinical outcome.
  
  
  
  178 of 540 ELISA-3 patients participated in the angiographic substudy. MLD at 9 months angiography was 2.37±0.63 mm (DES) versus 1.84±0.62 mm (BMS), p<0.001. Binary restenosis occurred in 1.9% in the DES group versus 16.7% in the BMS group (RR 0.11, 95% CI 0.02 to 0.84, p=0.007). In the pooled analysis, the incidence of MACE, target vessel revascularisation and ST at 2 years follow-up in the DES versus BMS group was 12.5% versus 16.0% (p=0.28), 4.0% versus 10.4% (p=0.009) and 1.3% versus 3.0% (p=0.34), respectively.
  
  
  
  In patients with NSTEMI, use of EES is safe and decreases both angiographic and clinical restenosis as compared to BMS http://www.isrctn.com/search?q=39230163.
  
  
  
  39230163; Post-results.
authors.affiliation: Isala heart centre , Zwolle , The Netherlands.
authors.forename: Wouter S
authors.initials: WS
authors.lastname: Remkes
authors.affiliation: Deventer Ziekenhuis , Deventer , The Netherlands.
authors.forename: Erik A
authors.initials: EA
authors.lastname: Badings
authors.affiliation: Isala heart centre , Zwolle , The Netherlands.
authors.forename: Renicus S
authors.initials: RS
authors.lastname: Hermanides
authors.affiliation: Maastricht University Medical Center , Maastricht , The Netherlands.
authors.forename: Saman
authors.initials: S
authors.lastname: Rasoul
authors.affiliation: Isala heart centre , Zwolle , The Netherlands.
authors.forename: Jan-Henk E
authors.initials: JE
authors.lastname: Dambrink
authors.affiliation: Isala heart centre , Zwolle , The Netherlands.
authors.forename: Petra C
authors.initials: PC
authors.lastname: Koopmans
authors.affiliation: Ziekenhuis Bethesda , Hoogeveen , The Netherlands.
authors.forename: Salem Hk
authors.initials: SH
authors.lastname: The
authors.affiliation: Isala heart centre , Zwolle , The Netherlands.
authors.forename: Jan Paul
authors.initials: JP
authors.lastname: Ottervanger
authors.affiliation: Isala heart centre , Zwolle , The Netherlands.
authors.forename: A T Marcel
authors.initials: AT
authors.lastname: Gosselink
authors.affiliation: Maastricht University Medical Center , Maastricht , The Netherlands.
authors.forename: Jan Ca
authors.initials: JC
authors.lastname: Hoorntje
authors.affiliation: Isala heart centre, Zwolle, The Netherlands; Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
authors.forename: Harry
authors.initials: H
authors.lastname: Suryapranata
authors.affiliation: Isala heart centre , Zwolle , The Netherlands.
authors.forename: Arnoud Wj
authors.initials: AW
authors.lastname: van 't Hof