title: A head-to-head comparison between CT- and IVUS-derived coronary blood flow models.
abstract: The goal of this work is to compare coronary hemodynamics as predicted by computational blood flow models derived from two imaging modalities: coronary computed tomography angiography (CCTA) and intravascular ultrasound integrated with angiography (IVUS). Criteria to define boundary conditions are proposed to overcome the dissimilar anatomical definition delivered by both modalities. The strategy to define boundary conditions is novel in the present context, and naturally accounts for the flow redistribution induced by the resistance of coronary vessels. Hyperemic conditions are assumed to assess model predictions under stressed hemodynamic environments similar to those encountered in Fractional Flow Reserve (FFR) calculations. As results, it was found that CCTA models predict larger pressure drops, higher average blood velocity and smaller FFR. Concerning the flow rate at distal locations in the major vessels of interest, it was found that CCTA predicted smaller flow than IVUS, which is a consequence of a larger sensitivity of CCTA models to coronary steal phenomena. Comparisons to in-vivo measurements of FFR are shown.
authors.affiliation: National Laboratory for Scientific Computing, LNCC/MCTI, Av. Getúlio Vargas 333, 25651-075 Petrópolis, Brazil; National Institute of Science and Technology in Medicine Assisted by Scientific Computing, INCT-MACC, Petrópolis, Brazil.
authors.forename: C A
authors.initials: CA
authors.lastname: Bulant
authors.affiliation: National Laboratory for Scientific Computing, LNCC/MCTI, Av. Getúlio Vargas 333, 25651-075 Petrópolis, Brazil; National Institute of Science and Technology in Medicine Assisted by Scientific Computing, INCT-MACC, Petrópolis, Brazil. Electronic address: pjblanco@lncc.br.
authors.forename: P J
authors.initials: PJ
authors.lastname: Blanco
authors.affiliation: National Laboratory for Scientific Computing, LNCC/MCTI, Av. Getúlio Vargas 333, 25651-075 Petrópolis, Brazil; National Institute of Science and Technology in Medicine Assisted by Scientific Computing, INCT-MACC, Petrópolis, Brazil.
authors.forename: G D
authors.initials: GD
authors.lastname: Maso Talou
authors.affiliation: Heart Institute, University of São Paulo Medical School, INCOR-FM-USP, Av. Dr. Eneas de Carvalho Aguiar 44, 3rd floor, 05403-000 São Paulo, Brazil.
authors.forename: C Guedes
authors.initials: CG
authors.lastname: Bezerra
authors.affiliation: Heart Institute, University of São Paulo Medical School, INCOR-FM-USP, Av. Dr. Eneas de Carvalho Aguiar 44, 3rd floor, 05403-000 São Paulo, Brazil.
authors.forename: P A
authors.initials: PA
authors.lastname: Lemos
authors.affiliation: National Laboratory for Scientific Computing, LNCC/MCTI, Av. Getúlio Vargas 333, 25651-075 Petrópolis, Brazil; National Institute of Science and Technology in Medicine Assisted by Scientific Computing, INCT-MACC, Petrópolis, Brazil.
authors.forename: R A
authors.initials: RA
authors.lastname: Feijóo
mesh_terms: D000368:Aged; D017023:Coronary Angiography; D003326:Coronary Circulation; D003331:Coronary Vessels / Q000502:physiology; D005260:Female; D053805:Fractional Flow Reserve, Myocardial; D006321:Heart / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
keywords: Angiography; Computed tomography; Coronary blood flow; Fractional flow reserve; Intravascular ultrasound; Wall shear stress