title: Ezetimibe in Combination With Statins Ameliorates Endothelial Dysfunction in Coronary Arteries After Stenting: The CuVIC Trial (Effect of Cholesterol Absorption Inhibitor Usage on Target Vessel Dysfunction After Coronary Stenting), a Multicenter Randomized Controlled Trial.
abstract: We sought to investigate whether treatment with ezetimibe in combination with statins improves coronary endothelial function in target vessels in coronary artery disease patients after coronary stenting.
  
  
  
  We conducted a multicenter, prospective, randomized, open-label, blinded-end point trial among 11 cardiovascular treatment centers. From 2011 to 2013, 260 coronary artery disease patients who underwent coronary stenting were randomly allocated to 2 arms (statin monotherapy, S versus ezetimibe [10 mg/d]+statin combinational therapy, E+S). We defined target vessel dysfunction as the primary composite outcome, which comprised target vessel failure during treatment and at the 6- to 8-month follow-up coronary angiography and coronary endothelial dysfunction determined via intracoronary acetylcholine testing performed in cases without target vessel failure at the follow-up coronary angiography. Coadministration of ezetimibe with statins further lowered low-density lipoprotein cholesterol levels (83±23 mg/dL in S versus 67±23 mg/dL in E+S; P<0.0001), with significant decreases in oxidized low-density lipoprotein and oxysterol levels. Among patients without target vessel failure, 46 out of 89 patients (52%) in the S arm and 34 out of 96 patients (35%) in the E+S arm were found to have coronary endothelial dysfunction (P=0.0256), and the incidence of target vessel dysfunction at follow-up was significantly decreased in the E+S arm (69/112 (62%) in S versus 47/109 (43%) in E+S; P=0.0059). A post hoc analysis of post-treatment low-density lipoprotein cholesterol-matched subgroups revealed that the incidence of both target vessel dysfunction and coronary endothelial dysfunction significantly decreased in the E+S arm, with significant reductions in oxysterol levels.
  
  
  
  The CuVIC trial (Effect of Cholesterol Absorption Inhibitor Usage on Target Vessel Dysfunction after Coronary Stenting) has shown that ezetimibe with statins, compared with statin monotherapy, improves functional prognoses, ameliorating endothelial dysfunction in stented coronary arteries, and was associated with larger decreases in oxysterol levels.
authors.affiliation: From the Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan (S.T., T.M., S.N., T.H., K. Egashira, K. Sunagawa); Department of Cardiovascular Medicine, Kyushu University Hospital, Fukuoka, Japan (S.T., T.M., S.N., Y.M., S.I., K.O., T.H., S.K., M.T., K. Sunagawa); Japanese Red Cross Fukuoka Hospital, Japan (N.S.); St. Mary's Hospital, Kurume, Japan (K. Eshima); Japan Community Health Care Organization, Kyushu Hospital, Fukuoka, Japan (K.M.); Harasanshin Hospital, Fukuoka, Japan (M.Y.); Hamanomachi Hospital, Fukuoka, Japan (M.U.); Saga-ken Medical Centre Koseikan, Saga, Japan (K. Sadamatsu); National Hospital Organization Kyushu Medical Centre, Fukuoka, Japan (S.S.); Saiseikai Futsukaichi Hospital, Chikushino, Japan (T.K.); Saiseikai Fukuoka General Hospital, Japan; Fukuoka City Hospital, Japan (K.H.); Graduate School of Humanities and Science, Ochanomizu University, Tokyo, Japan (I.I.); Center for Clinical and Translational Research, Kyushu University, Fukuoka, Japan (K.T., J.K.); and Department of Research and Development of Next Generation Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka, Japan (J.K.).
authors.forename: Susumu
authors.initials: S
authors.lastname: Takase
authors.affiliation: From the Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan (S.T., T.M., S.N., T.H., K. Egashira, K. Sunagawa); Department of Cardiovascular Medicine, Kyushu University Hospital, Fukuoka, Japan (S.T., T.M., S.N., Y.M., S.I., K.O., T.H., S.K., M.T., K. Sunagawa); Japanese Red Cross Fukuoka Hospital, Japan (N.S.); St. Mary's Hospital, Kurume, Japan (K. Eshima); Japan Community Health Care Organization, Kyushu Hospital, Fukuoka, Japan (K.M.); Harasanshin Hospital, Fukuoka, Japan (M.Y.); Hamanomachi Hospital, Fukuoka, Japan (M.U.); Saga-ken Medical Centre Koseikan, Saga, Japan (K. Sadamatsu); National Hospital Organization Kyushu Medical Centre, Fukuoka, Japan (S.S.); Saiseikai Futsukaichi Hospital, Chikushino, Japan (T.K.); Saiseikai Fukuoka General Hospital, Japan; Fukuoka City Hospital, Japan (K.H.); Graduate School of Humanities and Science, Ochanomizu University, Tokyo, Japan (I.I.); Center for Clinical and Translational Research, Kyushu University, Fukuoka, Japan (K.T., J.K.); and Department of Research and Development of Next Generation Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka, Japan (J.K.). matoba@cardiol.med.kyushu-u.ac.jp.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Matoba
authors.affiliation: From the Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan (S.T., T.M., S.N., T.H., K. Egashira, K. Sunagawa); Department of Cardiovascular Medicine, Kyushu University Hospital, Fukuoka, Japan (S.T., T.M., S.N., Y.M., S.I., K.O., T.H., S.K., M.T., K. Sunagawa); Japanese Red Cross Fukuoka Hospital, Japan (N.S.); St. Mary's Hospital, Kurume, Japan (K. Eshima); Japan Community Health Care Organization, Kyushu Hospital, Fukuoka, Japan (K.M.); Harasanshin Hospital, Fukuoka, Japan (M.Y.); Hamanomachi Hospital, Fukuoka, Japan (M.U.); Saga-ken Medical Centre Koseikan, Saga, Japan (K. Sadamatsu); National Hospital Organization Kyushu Medical Centre, Fukuoka, Japan (S.S.); Saiseikai Futsukaichi Hospital, Chikushino, Japan (T.K.); Saiseikai Fukuoka General Hospital, Japan; Fukuoka City Hospital, Japan (K.H.); Graduate School of Humanities and Science, Ochanomizu University, Tokyo, Japan (I.I.); Center for Clinical and Translational Research, Kyushu University, Fukuoka, Japan (K.T., J.K.); and Department of Research and Development of Next Generation Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka, Japan (J.K.).
authors.forename: Soichi
authors.initials: S
authors.lastname: Nakashiro
authors.affiliation: From the Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan (S.T., T.M., S.N., T.H., K. Egashira, K. Sunagawa); Department of Cardiovascular Medicine, Kyushu University Hospital, Fukuoka, Japan (S.T., T.M., S.N., Y.M., S.I., K.O., T.H., S.K., M.T., K. Sunagawa); Japanese Red Cross Fukuoka Hospital, Japan (N.S.); St. Mary's Hospital, Kurume, Japan (K. Eshima); Japan Community Health Care Organization, Kyushu Hospital, Fukuoka, Japan (K.M.); Harasanshin Hospital, Fukuoka, Japan (M.Y.); Hamanomachi Hospital, Fukuoka, Japan (M.U.); Saga-ken Medical Centre Koseikan, Saga, Japan (K. Sadamatsu); National Hospital Organization Kyushu Medical Centre, Fukuoka, Japan (S.S.); Saiseikai Futsukaichi Hospital, Chikushino, Japan (T.K.); Saiseikai Fukuoka General Hospital, Japan; Fukuoka City Hospital, Japan (K.H.); Graduate School of Humanities and Science, Ochanomizu University, Tokyo, Japan (I.I.); Center for Clinical and Translational Research, Kyushu University, Fukuoka, Japan (K.T., J.K.); and Department of Research and Development of Next Generation Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka, Japan (J.K.).
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Mukai
authors.affiliation: From the Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan (S.T., T.M., S.N., T.H., K. Egashira, K. Sunagawa); Department of Cardiovascular Medicine, Kyushu University Hospital, Fukuoka, Japan (S.T., T.M., S.N., Y.M., S.I., K.O., T.H., S.K., M.T., K. Sunagawa); Japanese Red Cross Fukuoka Hospital, Japan (N.S.); St. Mary's Hospital, Kurume, Japan (K. Eshima); Japan Community Health Care Organization, Kyushu Hospital, Fukuoka, Japan (K.M.); Harasanshin Hospital, Fukuoka, Japan (M.Y.); Hamanomachi Hospital, Fukuoka, Japan (M.U.); Saga-ken Medical Centre Koseikan, Saga, Japan (K. Sadamatsu); National Hospital Organization Kyushu Medical Centre, Fukuoka, Japan (S.S.); Saiseikai Futsukaichi Hospital, Chikushino, Japan (T.K.); Saiseikai Fukuoka General Hospital, Japan; Fukuoka City Hospital, Japan (K.H.); Graduate School of Humanities and Science, Ochanomizu University, Tokyo, Japan (I.I.); Center for Clinical and Translational Research, Kyushu University, Fukuoka, Japan (K.T., J.K.); and Department of Research and Development of Next Generation Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka, Japan (J.K.).
authors.forename: Shujiro
authors.initials: S
authors.lastname: Inoue
authors.affiliation: From the Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan (S.T., T.M., S.N., T.H., K. Egashira, K. Sunagawa); Department of Cardiovascular Medicine, Kyushu University Hospital, Fukuoka, Japan (S.T., T.M., S.N., Y.M., S.I., K.O., T.H., S.K., M.T., K. Sunagawa); Japanese Red Cross Fukuoka Hospital, Japan (N.S.); St. Mary's Hospital, Kurume, Japan (K. Eshima); Japan Community Health Care Organization, Kyushu Hospital, Fukuoka, Japan (K.M.); Harasanshin Hospital, Fukuoka, Japan (M.Y.); Hamanomachi Hospital, Fukuoka, Japan (M.U.); Saga-ken Medical Centre Koseikan, Saga, Japan (K. Sadamatsu); National Hospital Organization Kyushu Medical Centre, Fukuoka, Japan (S.S.); Saiseikai Futsukaichi Hospital, Chikushino, Japan (T.K.); Saiseikai Fukuoka General Hospital, Japan; Fukuoka City Hospital, Japan (K.H.); Graduate School of Humanities and Science, Ochanomizu University, Tokyo, Japan (I.I.); Center for Clinical and Translational Research, Kyushu University, Fukuoka, Japan (K.T., J.K.); and Department of Research and Development of Next Generation Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka, Japan (J.K.).
authors.forename: Keiji
authors.initials: K
authors.lastname: Oi
authors.affiliation: From the Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan (S.T., T.M., S.N., T.H., K. Egashira, K. Sunagawa); Department of Cardiovascular Medicine, Kyushu University Hospital, Fukuoka, Japan (S.T., T.M., S.N., Y.M., S.I., K.O., T.H., S.K., M.T., K. Sunagawa); Japanese Red Cross Fukuoka Hospital, Japan (N.S.); St. Mary's Hospital, Kurume, Japan (K. Eshima); Japan Community Health Care Organization, Kyushu Hospital, Fukuoka, Japan (K.M.); Harasanshin Hospital, Fukuoka, Japan (M.Y.); Hamanomachi Hospital, Fukuoka, Japan (M.U.); Saga-ken Medical Centre Koseikan, Saga, Japan (K. Sadamatsu); National Hospital Organization Kyushu Medical Centre, Fukuoka, Japan (S.S.); Saiseikai Futsukaichi Hospital, Chikushino, Japan (T.K.); Saiseikai Fukuoka General Hospital, Japan; Fukuoka City Hospital, Japan (K.H.); Graduate School of Humanities and Science, Ochanomizu University, Tokyo, Japan (I.I.); Center for Clinical and Translational Research, Kyushu University, Fukuoka, Japan (K.T., J.K.); and Department of Research and Development of Next Generation Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka, Japan (J.K.).
authors.forename: Taiki
authors.initials: T
authors.lastname: Higo
authors.affiliation: From the Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan (S.T., T.M., S.N., T.H., K. Egashira, K. Sunagawa); Department of Cardiovascular Medicine, Kyushu University Hospital, Fukuoka, Japan (S.T., T.M., S.N., Y.M., S.I., K.O., T.H., S.K., M.T., K. Sunagawa); Japanese Red Cross Fukuoka Hospital, Japan (N.S.); St. Mary's Hospital, Kurume, Japan (K. Eshima); Japan Community Health Care Organization, Kyushu Hospital, Fukuoka, Japan (K.M.); Harasanshin Hospital, Fukuoka, Japan (M.Y.); Hamanomachi Hospital, Fukuoka, Japan (M.U.); Saga-ken Medical Centre Koseikan, Saga, Japan (K. Sadamatsu); National Hospital Organization Kyushu Medical Centre, Fukuoka, Japan (S.S.); Saiseikai Futsukaichi Hospital, Chikushino, Japan (T.K.); Saiseikai Fukuoka General Hospital, Japan; Fukuoka City Hospital, Japan (K.H.); Graduate School of Humanities and Science, Ochanomizu University, Tokyo, Japan (I.I.); Center for Clinical and Translational Research, Kyushu University, Fukuoka, Japan (K.T., J.K.); and Department of Research and Development of Next Generation Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka, Japan (J.K.).
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Katsuki
authors.affiliation: From the Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan (S.T., T.M., S.N., T.H., K. Egashira, K. Sunagawa); Department of Cardiovascular Medicine, Kyushu University Hospital, Fukuoka, Japan (S.T., T.M., S.N., Y.M., S.I., K.O., T.H., S.K., M.T., K. Sunagawa); Japanese Red Cross Fukuoka Hospital, Japan (N.S.); St. Mary's Hospital, Kurume, Japan (K. Eshima); Japan Community Health Care Organization, Kyushu Hospital, Fukuoka, Japan (K.M.); Harasanshin Hospital, Fukuoka, Japan (M.Y.); Hamanomachi Hospital, Fukuoka, Japan (M.U.); Saga-ken Medical Centre Koseikan, Saga, Japan (K. Sadamatsu); National Hospital Organization Kyushu Medical Centre, Fukuoka, Japan (S.S.); Saiseikai Futsukaichi Hospital, Chikushino, Japan (T.K.); Saiseikai Fukuoka General Hospital, Japan; Fukuoka City Hospital, Japan (K.H.); Graduate School of Humanities and Science, Ochanomizu University, Tokyo, Japan (I.I.); Center for Clinical and Translational Research, Kyushu University, Fukuoka, Japan (K.T., J.K.); and Department of Research and Development of Next Generation Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka, Japan (J.K.).
authors.forename: Masao
authors.initials: M
authors.lastname: Takemoto
authors.affiliation: From the Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan (S.T., T.M., S.N., T.H., K. Egashira, K. Sunagawa); Department of Cardiovascular Medicine, Kyushu University Hospital, Fukuoka, Japan (S.T., T.M., S.N., Y.M., S.I., K.O., T.H., S.K., M.T., K. Sunagawa); Japanese Red Cross Fukuoka Hospital, Japan (N.S.); St. Mary's Hospital, Kurume, Japan (K. Eshima); Japan Community Health Care Organization, Kyushu Hospital, Fukuoka, Japan (K.M.); Harasanshin Hospital, Fukuoka, Japan (M.Y.); Hamanomachi Hospital, Fukuoka, Japan (M.U.); Saga-ken Medical Centre Koseikan, Saga, Japan (K. Sadamatsu); National Hospital Organization Kyushu Medical Centre, Fukuoka, Japan (S.S.); Saiseikai Futsukaichi Hospital, Chikushino, Japan (T.K.); Saiseikai Fukuoka General Hospital, Japan; Fukuoka City Hospital, Japan (K.H.); Graduate School of Humanities and Science, Ochanomizu University, Tokyo, Japan (I.I.); Center for Clinical and Translational Research, Kyushu University, Fukuoka, Japan (K.T., J.K.); and Department of Research and Development of Next Generation Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka, Japan (J.K.).
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Suematsu
authors.affiliation: From the Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan (S.T., T.M., S.N., T.H., K. Egashira, K. Sunagawa); Department of Cardiovascular Medicine, Kyushu University Hospital, Fukuoka, Japan (S.T., T.M., S.N., Y.M., S.I., K.O., T.H., S.K., M.T., K. Sunagawa); Japanese Red Cross Fukuoka Hospital, Japan (N.S.); St. Mary's Hospital, Kurume, Japan (K. Eshima); Japan Community Health Care Organization, Kyushu Hospital, Fukuoka, Japan (K.M.); Harasanshin Hospital, Fukuoka, Japan (M.Y.); Hamanomachi Hospital, Fukuoka, Japan (M.U.); Saga-ken Medical Centre Koseikan, Saga, Japan (K. Sadamatsu); National Hospital Organization Kyushu Medical Centre, Fukuoka, Japan (S.S.); Saiseikai Futsukaichi Hospital, Chikushino, Japan (T.K.); Saiseikai Fukuoka General Hospital, Japan; Fukuoka City Hospital, Japan (K.H.); Graduate School of Humanities and Science, Ochanomizu University, Tokyo, Japan (I.I.); Center for Clinical and Translational Research, Kyushu University, Fukuoka, Japan (K.T., J.K.); and Department of Research and Development of Next Generation Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka, Japan (J.K.).
authors.forename: Kenichi
authors.initials: K
authors.lastname: Eshima
authors.affiliation: From the Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan (S.T., T.M., S.N., T.H., K. Egashira, K. Sunagawa); Department of Cardiovascular Medicine, Kyushu University Hospital, Fukuoka, Japan (S.T., T.M., S.N., Y.M., S.I., K.O., T.H., S.K., M.T., K. Sunagawa); Japanese Red Cross Fukuoka Hospital, Japan (N.S.); St. Mary's Hospital, Kurume, Japan (K. Eshima); Japan Community Health Care Organization, Kyushu Hospital, Fukuoka, Japan (K.M.); Harasanshin Hospital, Fukuoka, Japan (M.Y.); Hamanomachi Hospital, Fukuoka, Japan (M.U.); Saga-ken Medical Centre Koseikan, Saga, Japan (K. Sadamatsu); National Hospital Organization Kyushu Medical Centre, Fukuoka, Japan (S.S.); Saiseikai Futsukaichi Hospital, Chikushino, Japan (T.K.); Saiseikai Fukuoka General Hospital, Japan; Fukuoka City Hospital, Japan (K.H.); Graduate School of Humanities and Science, Ochanomizu University, Tokyo, Japan (I.I.); Center for Clinical and Translational Research, Kyushu University, Fukuoka, Japan (K.T., J.K.); and Department of Research and Development of Next Generation Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka, Japan (J.K.).
authors.forename: Kenji
authors.initials: K
authors.lastname: Miyata
authors.affiliation: From the Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan (S.T., T.M., S.N., T.H., K. Egashira, K. Sunagawa); Department of Cardiovascular Medicine, Kyushu University Hospital, Fukuoka, Japan (S.T., T.M., S.N., Y.M., S.I., K.O., T.H., S.K., M.T., K. Sunagawa); Japanese Red Cross Fukuoka Hospital, Japan (N.S.); St. Mary's Hospital, Kurume, Japan (K. Eshima); Japan Community Health Care Organization, Kyushu Hospital, Fukuoka, Japan (K.M.); Harasanshin Hospital, Fukuoka, Japan (M.Y.); Hamanomachi Hospital, Fukuoka, Japan (M.U.); Saga-ken Medical Centre Koseikan, Saga, Japan (K. Sadamatsu); National Hospital Organization Kyushu Medical Centre, Fukuoka, Japan (S.S.); Saiseikai Futsukaichi Hospital, Chikushino, Japan (T.K.); Saiseikai Fukuoka General Hospital, Japan; Fukuoka City Hospital, Japan (K.H.); Graduate School of Humanities and Science, Ochanomizu University, Tokyo, Japan (I.I.); Center for Clinical and Translational Research, Kyushu University, Fukuoka, Japan (K.T., J.K.); and Department of Research and Development of Next Generation Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka, Japan (J.K.).
authors.forename: Mitsutaka
authors.initials: M
authors.lastname: Yamamoto
authors.affiliation: From the Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan (S.T., T.M., S.N., T.H., K. Egashira, K. Sunagawa); Department of Cardiovascular Medicine, Kyushu University Hospital, Fukuoka, Japan (S.T., T.M., S.N., Y.M., S.I., K.O., T.H., S.K., M.T., K. Sunagawa); Japanese Red Cross Fukuoka Hospital, Japan (N.S.); St. Mary's Hospital, Kurume, Japan (K. Eshima); Japan Community Health Care Organization, Kyushu Hospital, Fukuoka, Japan (K.M.); Harasanshin Hospital, Fukuoka, Japan (M.Y.); Hamanomachi Hospital, Fukuoka, Japan (M.U.); Saga-ken Medical Centre Koseikan, Saga, Japan (K. Sadamatsu); National Hospital Organization Kyushu Medical Centre, Fukuoka, Japan (S.S.); Saiseikai Futsukaichi Hospital, Chikushino, Japan (T.K.); Saiseikai Fukuoka General Hospital, Japan; Fukuoka City Hospital, Japan (K.H.); Graduate School of Humanities and Science, Ochanomizu University, Tokyo, Japan (I.I.); Center for Clinical and Translational Research, Kyushu University, Fukuoka, Japan (K.T., J.K.); and Department of Research and Development of Next Generation Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka, Japan (J.K.).
authors.forename: Makoto
authors.initials: M
authors.lastname: Usui
authors.affiliation: From the Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan (S.T., T.M., S.N., T.H., K. Egashira, K. Sunagawa); Department of Cardiovascular Medicine, Kyushu University Hospital, Fukuoka, Japan (S.T., T.M., S.N., Y.M., S.I., K.O., T.H., S.K., M.T., K. Sunagawa); Japanese Red Cross Fukuoka Hospital, Japan (N.S.); St. Mary's Hospital, Kurume, Japan (K. Eshima); Japan Community Health Care Organization, Kyushu Hospital, Fukuoka, Japan (K.M.); Harasanshin Hospital, Fukuoka, Japan (M.Y.); Hamanomachi Hospital, Fukuoka, Japan (M.U.); Saga-ken Medical Centre Koseikan, Saga, Japan (K. Sadamatsu); National Hospital Organization Kyushu Medical Centre, Fukuoka, Japan (S.S.); Saiseikai Futsukaichi Hospital, Chikushino, Japan (T.K.); Saiseikai Fukuoka General Hospital, Japan; Fukuoka City Hospital, Japan (K.H.); Graduate School of Humanities and Science, Ochanomizu University, Tokyo, Japan (I.I.); Center for Clinical and Translational Research, Kyushu University, Fukuoka, Japan (K.T., J.K.); and Department of Research and Development of Next Generation Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka, Japan (J.K.).
authors.forename: Kenji
authors.initials: K
authors.lastname: Sadamatsu
authors.affiliation: From the Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan (S.T., T.M., S.N., T.H., K. Egashira, K. Sunagawa); Department of Cardiovascular Medicine, Kyushu University Hospital, Fukuoka, Japan (S.T., T.M., S.N., Y.M., S.I., K.O., T.H., S.K., M.T., K. Sunagawa); Japanese Red Cross Fukuoka Hospital, Japan (N.S.); St. Mary's Hospital, Kurume, Japan (K. Eshima); Japan Community Health Care Organization, Kyushu Hospital, Fukuoka, Japan (K.M.); Harasanshin Hospital, Fukuoka, Japan (M.Y.); Hamanomachi Hospital, Fukuoka, Japan (M.U.); Saga-ken Medical Centre Koseikan, Saga, Japan (K. Sadamatsu); National Hospital Organization Kyushu Medical Centre, Fukuoka, Japan (S.S.); Saiseikai Futsukaichi Hospital, Chikushino, Japan (T.K.); Saiseikai Fukuoka General Hospital, Japan; Fukuoka City Hospital, Japan (K.H.); Graduate School of Humanities and Science, Ochanomizu University, Tokyo, Japan (I.I.); Center for Clinical and Translational Research, Kyushu University, Fukuoka, Japan (K.T., J.K.); and Department of Research and Development of Next Generation Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka, Japan (J.K.).
authors.forename: Shinji
authors.initials: S
authors.lastname: Satoh
authors.affiliation: From the Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan (S.T., T.M., S.N., T.H., K. Egashira, K. Sunagawa); Department of Cardiovascular Medicine, Kyushu University Hospital, Fukuoka, Japan (S.T., T.M., S.N., Y.M., S.I., K.O., T.H., S.K., M.T., K. Sunagawa); Japanese Red Cross Fukuoka Hospital, Japan (N.S.); St. Mary's Hospital, Kurume, Japan (K. Eshima); Japan Community Health Care Organization, Kyushu Hospital, Fukuoka, Japan (K.M.); Harasanshin Hospital, Fukuoka, Japan (M.Y.); Hamanomachi Hospital, Fukuoka, Japan (M.U.); Saga-ken Medical Centre Koseikan, Saga, Japan (K. Sadamatsu); National Hospital Organization Kyushu Medical Centre, Fukuoka, Japan (S.S.); Saiseikai Futsukaichi Hospital, Chikushino, Japan (T.K.); Saiseikai Fukuoka General Hospital, Japan; Fukuoka City Hospital, Japan (K.H.); Graduate School of Humanities and Science, Ochanomizu University, Tokyo, Japan (I.I.); Center for Clinical and Translational Research, Kyushu University, Fukuoka, Japan (K.T., J.K.); and Department of Research and Development of Next Generation Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka, Japan (J.K.).
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Kadokami
authors.affiliation: From the Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan (S.T., T.M., S.N., T.H., K. Egashira, K. Sunagawa); Department of Cardiovascular Medicine, Kyushu University Hospital, Fukuoka, Japan (S.T., T.M., S.N., Y.M., S.I., K.O., T.H., S.K., M.T., K. Sunagawa); Japanese Red Cross Fukuoka Hospital, Japan (N.S.); St. Mary's Hospital, Kurume, Japan (K. Eshima); Japan Community Health Care Organization, Kyushu Hospital, Fukuoka, Japan (K.M.); Harasanshin Hospital, Fukuoka, Japan (M.Y.); Hamanomachi Hospital, Fukuoka, Japan (M.U.); Saga-ken Medical Centre Koseikan, Saga, Japan (K. Sadamatsu); National Hospital Organization Kyushu Medical Centre, Fukuoka, Japan (S.S.); Saiseikai Futsukaichi Hospital, Chikushino, Japan (T.K.); Saiseikai Fukuoka General Hospital, Japan; Fukuoka City Hospital, Japan (K.H.); Graduate School of Humanities and Science, Ochanomizu University, Tokyo, Japan (I.I.); Center for Clinical and Translational Research, Kyushu University, Fukuoka, Japan (K.T., J.K.); and Department of Research and Development of Next Generation Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka, Japan (J.K.).
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Hironaga
authors.affiliation: From the Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan (S.T., T.M., S.N., T.H., K. Egashira, K. Sunagawa); Department of Cardiovascular Medicine, Kyushu University Hospital, Fukuoka, Japan (S.T., T.M., S.N., Y.M., S.I., K.O., T.H., S.K., M.T., K. Sunagawa); Japanese Red Cross Fukuoka Hospital, Japan (N.S.); St. Mary's Hospital, Kurume, Japan (K. Eshima); Japan Community Health Care Organization, Kyushu Hospital, Fukuoka, Japan (K.M.); Harasanshin Hospital, Fukuoka, Japan (M.Y.); Hamanomachi Hospital, Fukuoka, Japan (M.U.); Saga-ken Medical Centre Koseikan, Saga, Japan (K. Sadamatsu); National Hospital Organization Kyushu Medical Centre, Fukuoka, Japan (S.S.); Saiseikai Futsukaichi Hospital, Chikushino, Japan (T.K.); Saiseikai Fukuoka General Hospital, Japan; Fukuoka City Hospital, Japan (K.H.); Graduate School of Humanities and Science, Ochanomizu University, Tokyo, Japan (I.I.); Center for Clinical and Translational Research, Kyushu University, Fukuoka, Japan (K.T., J.K.); and Department of Research and Development of Next Generation Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka, Japan (J.K.).
authors.forename: Ikuyo
authors.initials: I
authors.lastname: Ichi
authors.affiliation: From the Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan (S.T., T.M., S.N., T.H., K. Egashira, K. Sunagawa); Department of Cardiovascular Medicine, Kyushu University Hospital, Fukuoka, Japan (S.T., T.M., S.N., Y.M., S.I., K.O., T.H., S.K., M.T., K. Sunagawa); Japanese Red Cross Fukuoka Hospital, Japan (N.S.); St. Mary's Hospital, Kurume, Japan (K. Eshima); Japan Community Health Care Organization, Kyushu Hospital, Fukuoka, Japan (K.M.); Harasanshin Hospital, Fukuoka, Japan (M.Y.); Hamanomachi Hospital, Fukuoka, Japan (M.U.); Saga-ken Medical Centre Koseikan, Saga, Japan (K. Sadamatsu); National Hospital Organization Kyushu Medical Centre, Fukuoka, Japan (S.S.); Saiseikai Futsukaichi Hospital, Chikushino, Japan (T.K.); Saiseikai Fukuoka General Hospital, Japan; Fukuoka City Hospital, Japan (K.H.); Graduate School of Humanities and Science, Ochanomizu University, Tokyo, Japan (I.I.); Center for Clinical and Translational Research, Kyushu University, Fukuoka, Japan (K.T., J.K.); and Department of Research and Development of Next Generation Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka, Japan (J.K.).
authors.forename: Koji
authors.initials: K
authors.lastname: Todaka
authors.affiliation: From the Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan (S.T., T.M., S.N., T.H., K. Egashira, K. Sunagawa); Department of Cardiovascular Medicine, Kyushu University Hospital, Fukuoka, Japan (S.T., T.M., S.N., Y.M., S.I., K.O., T.H., S.K., M.T., K. Sunagawa); Japanese Red Cross Fukuoka Hospital, Japan (N.S.); St. Mary's Hospital, Kurume, Japan (K. Eshima); Japan Community Health Care Organization, Kyushu Hospital, Fukuoka, Japan (K.M.); Harasanshin Hospital, Fukuoka, Japan (M.Y.); Hamanomachi Hospital, Fukuoka, Japan (M.U.); Saga-ken Medical Centre Koseikan, Saga, Japan (K. Sadamatsu); National Hospital Organization Kyushu Medical Centre, Fukuoka, Japan (S.S.); Saiseikai Futsukaichi Hospital, Chikushino, Japan (T.K.); Saiseikai Fukuoka General Hospital, Japan; Fukuoka City Hospital, Japan (K.H.); Graduate School of Humanities and Science, Ochanomizu University, Tokyo, Japan (I.I.); Center for Clinical and Translational Research, Kyushu University, Fukuoka, Japan (K.T., J.K.); and Department of Research and Development of Next Generation Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka, Japan (J.K.).
authors.forename: Junji
authors.initials: J
authors.lastname: Kishimoto
authors.affiliation: From the Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan (S.T., T.M., S.N., T.H., K. Egashira, K. Sunagawa); Department of Cardiovascular Medicine, Kyushu University Hospital, Fukuoka, Japan (S.T., T.M., S.N., Y.M., S.I., K.O., T.H., S.K., M.T., K. Sunagawa); Japanese Red Cross Fukuoka Hospital, Japan (N.S.); St. Mary's Hospital, Kurume, Japan (K. Eshima); Japan Community Health Care Organization, Kyushu Hospital, Fukuoka, Japan (K.M.); Harasanshin Hospital, Fukuoka, Japan (M.Y.); Hamanomachi Hospital, Fukuoka, Japan (M.U.); Saga-ken Medical Centre Koseikan, Saga, Japan (K. Sadamatsu); National Hospital Organization Kyushu Medical Centre, Fukuoka, Japan (S.S.); Saiseikai Futsukaichi Hospital, Chikushino, Japan (T.K.); Saiseikai Fukuoka General Hospital, Japan; Fukuoka City Hospital, Japan (K.H.); Graduate School of Humanities and Science, Ochanomizu University, Tokyo, Japan (I.I.); Center for Clinical and Translational Research, Kyushu University, Fukuoka, Japan (K.T., J.K.); and Department of Research and Development of Next Generation Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka, Japan (J.K.).
authors.forename: Kensuke
authors.initials: K
authors.lastname: Egashira
authors.affiliation: From the Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan (S.T., T.M., S.N., T.H., K. Egashira, K. Sunagawa); Department of Cardiovascular Medicine, Kyushu University Hospital, Fukuoka, Japan (S.T., T.M., S.N., Y.M., S.I., K.O., T.H., S.K., M.T., K. Sunagawa); Japanese Red Cross Fukuoka Hospital, Japan (N.S.); St. Mary's Hospital, Kurume, Japan (K. Eshima); Japan Community Health Care Organization, Kyushu Hospital, Fukuoka, Japan (K.M.); Harasanshin Hospital, Fukuoka, Japan (M.Y.); Hamanomachi Hospital, Fukuoka, Japan (M.U.); Saga-ken Medical Centre Koseikan, Saga, Japan (K. Sadamatsu); National Hospital Organization Kyushu Medical Centre, Fukuoka, Japan (S.S.); Saiseikai Futsukaichi Hospital, Chikushino, Japan (T.K.); Saiseikai Fukuoka General Hospital, Japan; Fukuoka City Hospital, Japan (K.H.); Graduate School of Humanities and Science, Ochanomizu University, Tokyo, Japan (I.I.); Center for Clinical and Translational Research, Kyushu University, Fukuoka, Japan (K.T., J.K.); and Department of Research and Development of Next Generation Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka, Japan (J.K.).
authors.forename: Kenji
authors.initials: K
authors.lastname: Sunagawa
mesh_terms: D000109:Acetylcholine / Q000008:administration & dosage; D000368:Aged; D000924:Anticholesteremic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D003331:Coronary Vessels / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000503:physiopathology; D004338:Drug Combinations; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000503:physiopathology; D000069438:Ezetimibe / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D007564:Japan; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D000072376:Oxysterols / Q000097:blood; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects / Q000295:instrumentation*; D011446:Prospective Studies; D015607:Stents; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000924:Anticholesteremic Agents; D015415:Biomarkers; D008078:Cholesterol, LDL; D004338:Drug Combinations; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008077:Lipoproteins, LDL; D000072376:Oxysterols; C099252:oxidized low density lipoprotein; D000069438:Ezetimibe; D000109:Acetylcholine
keywords: acetylcholine; endothelium; ezetimibe; oxysterols; percutaneous coronary intervention; statins