title: PARP1 orchestrates epigenetic events setting up chromatin domains.
abstract: Epigenetic events include reversible modifications of DNA and histone tails driving chromatin organization and thus transcription. The epigenetic regulation is a highly integrated process underlying the plasticity of the genomic information both in the context of complex physiological and pathological processes. The global regulatory aspects of epigenetic events are largely unknown. PARylation and PARP1 are recently emerging as multi-level regulatory effectors that modulate the topology of chromatin by orchestrating very different processes. This review focuses in particular on the role of PARP1 in epigenetics, trying to build a comprehensive perspective of its involvement in the regulation of epigenetic modifications of histones and DNA, contextualizing it in the global organization of chromatin domains in the nucleus.
authors.affiliation: Department of Biology, Faculty of Mathematics, Physics and Natural Sciences, University of Rome 'Tor Vergata', Rome, Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Ciccarone
authors.affiliation: Department of Cellular Biotechnologies and Haematology, Faculty of Pharmacy and Medicine, 'Sapienza' University of Rome, Rome, Italy; Pasteur Institute-Cenci Bolognetti Foundation, Rome, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Zampieri
authors.affiliation: Department of Cellular Biotechnologies and Haematology, Faculty of Pharmacy and Medicine, 'Sapienza' University of Rome, Rome, Italy; Pasteur Institute-Cenci Bolognetti Foundation, Rome, Italy. Electronic address: caiafa@bce.uniroma1.it.
authors.forename: Paola
authors.initials: P
authors.lastname: Caiafa
mesh_terms: D000074744:ADP-Ribosylation; D000818:Animals; D002843:Chromatin / Q000378:metabolism*; D044127:Epigenesis, Genetic; D006801:Humans; D008954:Models, Biological; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism*
chemical_list: D002843:Chromatin; D011065:Poly(ADP-ribose) Polymerases
keywords: Chromatin; DNA hydroxymethylation; DNA methylation; Epigenetic regulation; Histone acetylation; Histone methylation; PARP1; PARylation