title: Anti-Xa monitoring of low-molecular-weight heparin in adult patients with cancer.
abstract: A 68-year-old man developed a right femoral vein deep vein thrombosis and bilateral pulmonary embolism while receiving chemotherapy for stage IV prostate cancer. His creatinine at diagnosis is 1.4 mg/dL, with an estimated clearance of 63 mL/min. In patients with cancer, should low-molecular-weight heparin treatment be dosed according to weight, or adjusted using anti-Xa levels?
authors.affiliation: BloodCenter of Wisconsin, Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, WI, and.
authors.forename: Lisa Baumann
authors.initials: LB
authors.lastname: Kreuziger
authors.affiliation: Department of Medicine, Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, MD.
authors.forename: Michael
authors.initials: M
authors.lastname: Streiff
mesh_terms: D000328:Adult; D000368:Aged; D065427:Factor Xa Inhibitors / Q000008:administration & dosage / Q000493:pharmacokinetics; D006495:Heparin, Low-Molecular-Weight / Q000008:administration & dosage / Q000493:pharmacokinetics; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000097:blood / Q000188:drug therapy*; D011655:Pulmonary Embolism / Q000097:blood / Q000188:drug therapy / Q000209:etiology; D020246:Venous Thrombosis / Q000097:blood / Q000188:drug therapy / Q000209:etiology
chemical_list: D065427:Factor Xa Inhibitors; D006495:Heparin, Low-Molecular-Weight