title: The role of mesenchymal stem cells in oncology and regenerative medicine.
abstract: Mesenchymal stem cells (MSCs) have long been used as therapeutic agents in disease affecting various organ systems. However, MSCs are fast emerging as promising anticancer agents which have the potential to treat a number of different cancer types, including glioblastoma and metastatic breast, ovarian and hepatic carcinoma. The ability of MSC to migrate directly into the tumor microenvironment and to produce IFN-α and -β makes this possible. However, the possibility of MSC undergoing either malignant transformation or transformation into protumorigenic fibroblasts currently limits their role in clinical use. It is hoped that future research can overcome these limitations and facilitate the use of MSC clinically.
authors.affiliation: Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
authors.forename: Maliha
authors.initials: M
authors.lastname: Khan
authors.affiliation: Department of Internal Medicine, Dow University of Health Sciences, Karachi, Pakistan.
authors.forename: Syeda Ezze Rukhshan
authors.initials: SE
authors.lastname: Adil
authors.affiliation: Department of Stem Cell Transplantation, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
authors.forename: Amanda L
authors.initials: AL
authors.lastname: Olson
mesh_terms: D000818:Animals; D002465:Cell Movement; D016207:Cytokines / Q000378:metabolism; D015316:Genetic Therapy / Q000379:methods; D005822:Genetic Vectors / Q000008:administration & dosage / Q000235:genetics; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000378:metabolism*; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D044968:Regenerative Medicine; D014161:Transduction, Genetic; D019076:Transgenes; D059016:Tumor Microenvironment
chemical_list: D016207:Cytokines
keywords: MSC; antitumorigenic therapy; cancer microenvironment