title: Chronic lymphocytic leukemia and small lymphocytic lymphoma: two faces of the same disease.
abstract: Chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) are considered indolent lymphocytic malignancies, more often requiring active surveillance rather than intervention. Despite the indolent nature of CLL/SLL, treatment is likely indicated in a patients' lifetime. Recent changes in the therapeutic landscape have created more options to the clinician. Areas covered: The authors provide a broad assessment of the current state of disease, including the work-up, prognostic features, and mutational aspects of the disease that should be acknowledged when developing a rational treatment plan. Key studies, guideline recommendations, and expert analysis are used to create this update on CLL/SLL. Expert commentary: The recent pace of treatment additions in CLL/SLL is a welcome addition. Moving forward, it is anticipated that treatment modalities will continue to evolve, leading to additional management options that truly would define CLL/SLL as a chronic disease.
authors.affiliation: a Colorado Blood Cancer Institute , Denver , CO , USA.|c Sarah Cannon Blood Cancer Network , Nashville , TN , USA.
authors.forename: Michael T
authors.initials: MT
authors.lastname: Tees
authors.affiliation: b Tennesee Oncology , Nashville , TN , USA.|c Sarah Cannon Blood Cancer Network , Nashville , TN , USA.
authors.forename: Ian W
authors.initials: IW
authors.lastname: Flinn
mesh_terms: D001402:B-Lymphocytes / Q000378:metabolism / Q000473:pathology*; D015415:Biomarkers; D003131:Combined Modality Therapy; D006801:Humans; D016130:Immunophenotyping; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy; D009367:Neoplasm Staging; D010641:Phenotype; D011379:Prognosis; D012307:Risk Factors; D016896:Treatment Outcome; D057832:Watchful Waiting
chemical_list: D015415:Biomarkers
keywords: ATM; BIRC3; CLL/SLL; Chronic lymphocytic leukemia; NOTCH1; SF3B1; TP53; monoclonal B-cell lymphocytosis; small lymphocytic lymphoma