title: Anti-inflammatory effect of selenium nanoparticles on the inflammation induced in irradiated rats.
abstract: Selenium (Se) has been reported to possess anti-inflammatory properties, but its bioavailability and toxicity are considerable limiting factors. The present study aimed to investigate the possible anti-inflammatory and analgesic effects of selenium nanoparticles (Nano-Se) on inflammation induced in irradiated rats. Paw volume and nociceptive threshold were measured in carrageenan-induced paw edema and hyperalgesia model. Leukocytic count, tumor necrosis factor-α (TNF-α), prostaglandin E2(PGE2), thiobarbituric acid reactive substances (TBAR), and total nitrate/nitrite (NOx) were estimated in the exudate collected from 6 day old air pouch model. Irradiated rats were exposed to 6 Gy gamma (γ)-irradiation. Nano-Se were administered orally in a dose of 2.55 mg/kg once before carrageenan injection in the first model and twice in the second model. The paw volume but not the nociceptive response produced by carrageenan in irradiated rats was higher than that induced in non-irradiated rats. Nano-Se were effective in reducing the paw volume in non-irradiated and irradiated rats but it did not alter the nociceptive threshold. The inflammation induced in irradiated rats increased all the estimated parameters in the exudate whereas; Nano-Se decreased their elevation in non-irradiated and irradiated rats. Nano-Se possess a potential anti-inflammatory activity on inflammation induced in irradiated rats.
authors.affiliation: a Drug Radiation Research Department, National Centre for Radiation Research & Technology, Atomic Energy Authority, Ahmed El-Zomor Street, Nasr City, Cairo, Egypt.
authors.forename: M A
authors.initials: MA
authors.lastname: El-Ghazaly
authors.affiliation: a Drug Radiation Research Department, National Centre for Radiation Research & Technology, Atomic Energy Authority, Ahmed El-Zomor Street, Nasr City, Cairo, Egypt.
authors.forename: N
authors.initials: N
authors.lastname: Fadel
authors.affiliation: a Drug Radiation Research Department, National Centre for Radiation Research & Technology, Atomic Energy Authority, Ahmed El-Zomor Street, Nasr City, Cairo, Egypt.
authors.forename: E
authors.initials: E
authors.lastname: Rashed
authors.affiliation: a Drug Radiation Research Department, National Centre for Radiation Research & Technology, Atomic Energy Authority, Ahmed El-Zomor Street, Nasr City, Cairo, Egypt.
authors.forename: A
authors.initials: A
authors.lastname: El-Batal
authors.affiliation: b Pharmacology Department, Faculty of Pharmacy, Cairo University, Egypt.
authors.forename: S A
authors.initials: SA
authors.lastname: Kenawy
mesh_terms: D000700:Analgesics / Q000627:therapeutic use; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D015232:Dinoprostone; D007249:Inflammation / Q000188:drug therapy* / Q000378:metabolism; D007958:Leukocyte Count; D008297:Male; D053758:Nanoparticles / Q000627:therapeutic use*; D009566:Nitrates / Q000378:metabolism; D009573:Nitrites / Q000378:metabolism; D010147:Pain Measurement / Q000187:drug effects; D051381:Rats; D012643:Selenium / Q000627:therapeutic use*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D014916:Whole-Body Irradiation / Q000009:adverse effects
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D009566:Nitrates; D009573:Nitrites; D017392:Thiobarbituric Acid Reactive Substances; D014409:Tumor Necrosis Factor-alpha; D012643:Selenium; D015232:Dinoprostone
keywords: air pouch; carrageenan; carraghénine; gamma-irradiation; inflammation; irradiation gamma; nanoparticules de sélénium; nociceptive threshold; paw edema; poche d’air; selenium nanoparticles; seuil nociceptif; œdème de la patte