title: Memantine-induced chorea and dystonia.
abstract: Memantine is an uncompetitiveN-methyl-d-aspartate receptor antagonist and probably also has an indirect dopaminergic action at high concentrations. We describe a person with Alzheimer's disease who developed chorea and dystonia after inadvertently doubling of her daily dose by taking extended-release (XR) memantine twice daily, rather than once daily (planned dose memantine XR, 21 mg once daily), after the drug was switched from immediate release (IR, 10 mg twice daily). Memantine is rarely associated with movement disorders, but this case emphasises the need for awareness of potential problems when switching from memantine IR to XR.
authors.affiliation: Cognitive Neurology and Alzheimer's Disease Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
authors.forename: Letizia Goncalves
authors.identifier: http://orcid.org/0000-0002-6154-6571
authors.initials: LG
authors.lastname: Borges
authors.affiliation: Cognitive Neurology and Alzheimer's Disease Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.|The Ken and Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
authors.forename: Borna
authors.identifier: http://orcid.org/0000-0003-0028-0535
authors.initials: B
authors.lastname: Bonakdarpour
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000188:drug therapy; D014150:Antipsychotic Agents / Q000009:adverse effects*; D002819:Chorea / Q000139:chemically induced* / Q000150:complications; D004421:Dystonia / Q000139:chemically induced* / Q000150:complications; D005260:Female; D006801:Humans; D008559:Memantine / Q000009:adverse effects*
chemical_list: D014150:Antipsychotic Agents; D008559:Memantine
keywords: ALZHEIMER'S DISEASE; CHOREA; DEMENTIA; DYSTONIA; MEMANTINE