title: Proteomic profiling identifies N-acetylmuramoyl-l-alanine amidase as a novel biomarker of sepsis.
abstract: OBJECTIVE
  Sepsis is a critical condition that leads to high mortality and is the most common cause of death in intensive care units. Despite exhaustive efforts by the scientific community, a reliable biomarker for diagnosis, evolution and prognosis of sepsis is still lacking. Results & methodology: Here, using high-throughput proteomics, we describe N-acetylmuramoyl-l-alanine amidase as a novel candidate for differentiating infectious and noninfectious inflammatory syndromes.
  
  
  CONCLUSIONS
  This is the first description of N-acetylmuramoyl-l-alanine amidase as a biomarker that can be used alone or in conjunction with other biomarkers to facilitate the diagnosis of sepsis in the critically ill.
authors.affiliation: Emergency Medicine Department, University of Sao Paulo, Sao Paulo, Brazil.
authors.forename: Fabiano
authors.initials: F
authors.lastname: Pinheiro da Silva
authors.affiliation: Escola Superior de Agricultura 'Luiz de Queiroz', Department of Genetics, Laboratório Multiusuários Centralizado de Genômica Funcional Aplicada à Agropecuária e Agroenergia, University of Sao Paulo, Piracicaba, Brazil.
authors.forename: Thais Regiani
authors.initials: TR
authors.lastname: Cataldi
authors.affiliation: Emergency Medicine Department, University of Sao Paulo, Sao Paulo, Brazil.
authors.forename: Thais Martins
authors.initials: TM
authors.lastname: de Lima
authors.affiliation: Biosciences Institute, University of Sao Paulo, Sao Paulo, Brazil.
authors.forename: Paulo Nogueira
authors.initials: PN
authors.lastname: Starzynski
authors.affiliation: Emergency Medicine Department, University of Sao Paulo, Sao Paulo, Brazil.
authors.forename: Hermes Vieira
authors.initials: HV
authors.lastname: Barbeiro
authors.affiliation: Escola Superior de Agricultura 'Luiz de Queiroz', Department of Genetics, Laboratório Multiusuários Centralizado de Genômica Funcional Aplicada à Agropecuária e Agroenergia, University of Sao Paulo, Piracicaba, Brazil.
authors.forename: Monica Teresa Veneziano
authors.initials: MT
authors.lastname: Labate
authors.affiliation: Emergency Medicine Department, University of Sao Paulo, Sao Paulo, Brazil.
authors.forename: Marcel Cerqueira Cesar
authors.initials: MC
authors.lastname: CéMachado
authors.affiliation: Emergency Medicine Department, University of Sao Paulo, Sao Paulo, Brazil.
authors.forename: Heraldo Possolo
authors.initials: HP
authors.lastname: de Souza
authors.affiliation: Escola Superior de Agricultura 'Luiz de Queiroz', Department of Genetics, Laboratório Multiusuários Centralizado de Genômica Funcional Aplicada à Agropecuária e Agroenergia, University of Sao Paulo, Piracicaba, Brazil.
authors.forename: Carlos Alberto
authors.initials: CA
authors.lastname: Labate
mesh_terms: D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D002851:Chromatography, High Pressure Liquid; D041961:Deuterium Exchange Measurement; D006801:Humans; D007362:Intensive Care Units; D013058:Mass Spectrometry; D009238:N-Acetylmuramoyl-L-alanine Amidase / Q000097:blood*; D040901:Proteomics; D018805:Sepsis / Q000175:diagnosis* / Q000473:pathology
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein; D009238:N-Acetylmuramoyl-L-alanine Amidase
keywords: N-acetylmuramoyl-l-alanine amidase; biomarker; inflammation; proteomics; sepsis