title: Screening of process variables using Plackett-Burman design in the fabrication of gedunin-loaded liposomes.
abstract: This study is to screening the formulation and process variables that produce significant effect on the gedunin-loaded liposome formulations by using quality-by-design approach. Placket-Burman screening design was used to screen the most influencing formulation and process variables. Mean vesicle size, zeta potential, entrapment efficiency, and loading capacity were found in the range of 112-990 nm, -19.39 to -39.20 mV, 45.25-87.60%, and 3.54-10.47%, respectively. Differential scanning calorimetry (DSC) and powder X-ray diffraction (XRD) result suggested that Gedunin encapsulated within liposome as amorphous state. The analysis of Pareto chart represented that selected independent variables had a most significant effect on dependent variables.
authors.affiliation: a Department of Pharmacy , University Institute of Pharmacy, Affiliated by Pt. Ravishankar Shukla University , Raipur, Chhattisgarh , India.
authors.forename: Anil Kumar
authors.initials: AK
authors.lastname: Sahu
authors.affiliation: a Department of Pharmacy , University Institute of Pharmacy, Affiliated by Pt. Ravishankar Shukla University , Raipur, Chhattisgarh , India.
authors.forename: Vishal
authors.initials: V
authors.lastname: Jain
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000295:instrumentation / Q000379:methods*; D004339:Drug Compounding; D065546:Drug Liberation; D036701:Limonins / Q000008:administration & dosage / Q000737:chemistry*; D008081:Liposomes; D014867:Water / Q000737:chemistry
chemical_list: D036701:Limonins; D008081:Liposomes; D014867:Water; C106014:gedunin
keywords: Gedunin; Plackett–Burman design; liposome; quality by design