title: Lipid peroxidation in face of DNA damage, DNA repair and other cellular processes.
abstract: Exocyclic adducts to DNA bases are formed as a consequence of exposure to certain environmental carcinogens as well as inflammation and lipid peroxidation (LPO). Complex family of LPO products gives rise to a variety of DNA adducts, which can be grouped in two classes: (i) small etheno-type adducts of strong mutagenic potential, and (ii) bulky, propano-type adducts, which block replication and transcription, and are lethal lesions. Etheno-DNA adducts are removed from the DNA by base excision repair (BER), AlkB and nucleotide incision repair enzymes (NIR), while substituted propano-type lesions by nucleotide excision repair (NER) and homologous recombination (HR). Changes of the level and activity of several enzymes removing exocyclic adducts from the DNA was reported during carcinogenesis. Also several beyond repair functions of these enzymes, which participate in regulation of cell proliferation and growth, as well as RNA processing was recently described. In addition, adducts of LPO products to proteins was reported during aging and age-related diseases. The paper summarizes pathways for exocyclic adducts removal and describes how proteins involved in repair of these adducts can modify pathological states of the organism.
authors.affiliation: Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawińskiego 5a, 02-106 Warsaw, Poland; Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, Miecznikowa 1, 02-096 Warsaw, Poland. Electronic address: tudek@ibb.waw.pl.
authors.forename: Barbara
authors.initials: B
authors.lastname: Tudek
authors.affiliation: Laboratory of Cell Biology, International Institute of Molecular and Cell Biology, Ksiecia Trojdena 4, 02-109 Warsaw, Poland.
authors.forename: Daria
authors.initials: D
authors.lastname: Zdżalik-Bielecka
authors.affiliation: Department of Molecular Biology and Genetics, Aarhus University, C. F. Mollers Alle 3, 8000 Aarhus, Denmark.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Tudek
authors.affiliation: Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, Miecznikowa 1, 02-096 Warsaw, Poland.
authors.forename: Konrad
authors.initials: K
authors.lastname: Kosicki
authors.affiliation: Department of Molecular and Translational Oncology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Roentgena 5, Warsaw 02-781, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Fabisiewicz
authors.affiliation: Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawińskiego 5a, 02-106 Warsaw, Poland.
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Speina
mesh_terms: D000375:Aging; D000818:Animals; D063646:Carcinogenesis; D018736:DNA Adducts / Q000737:chemistry / Q000378:metabolism*; D004249:DNA Damage; D045647:DNA Glycosylases / Q000378:metabolism*; D004260:DNA Repair; D059765:Homologous Recombination; D006801:Humans; D015227:Lipid Peroxidation; D016296:Mutagenesis; D010084:Oxidation-Reduction
chemical_list: D018736:DNA Adducts; D045647:DNA Glycosylases
keywords: AlkB; BER; Enzyme modification; Etheno-DNA adducts; Homologous recombination; Lipid peroxidation; NER; NIR; Propano-DNA adducts; RNA processing