title: Pathogenic Features of Dysuria in Young Women with Secondary Amenorrhea Caused by Body Weight Loss.
abstract: We examined 11 women aged 19-26 years (mean age 22.5±3.5 years) with secondary amenorrhea complaining frequent urination over 1.5 years and repeatedly, but unsuccessful treated for overactive bladder and chronic cystitis. The rare cause of sustained urination disorders in young female patients of reproductive age was established: development of secondary amenorrhea caused by weight loss ("cosmetic" amenorrhea) with subsequent estrogene deficit and urogenital atrophy. Morphological examination of the bladder mucosa, an important clue to the diagnosis, helps to identify the true cause of dysuria, urogenital atrophy of the bladder mucosa, in secondary ("cosmetic") amenorrhea, and determine future course of etiopathogenic treatment of sustained dysuria in young women. The treatment is often effective in case of proper and timely diagnosis and the absence of irreversible changes.
authors.affiliation: Institute of Molecular Pathology and Pathomorphology, Novosibirsk, Russia.
authors.forename: N V
authors.initials: NV
authors.lastname: Shelkovnikova
authors.affiliation: Altay State Medical University, Ministry of Health of Russian Federation, Barnaul, Russia.
authors.forename: A I
authors.initials: AI
authors.lastname: Neimark
authors.affiliation: Altay State Medical University, Ministry of Health of Russian Federation, Barnaul, Russia.
authors.forename: T S
authors.initials: TS
authors.lastname: Taranina
authors.affiliation: Institute of Molecular Pathology and Pathomorphology, Novosibirsk, Russia.
authors.forename: A K
authors.initials: AK
authors.lastname: Pichigina
authors.affiliation: Institute of Molecular Pathology and Pathomorphology, Novosibirsk, Russia.
authors.forename: O P
authors.initials: OP
authors.lastname: Molodyh
authors.affiliation: Institute of Molecular Pathology and Pathomorphology, Novosibirsk, Russia. pathol@inbox.ru.
authors.forename: E L
authors.initials: EL
authors.lastname: Lushnikova
mesh_terms: D000328:Adult; D000568:Amenorrhea / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D016022:Case-Control Studies; D003556:Cystitis / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D053159:Dysuria / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D004958:Estradiol / Q000097:blood; D004967:Estrogens / Q000627:therapeutic use; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D020738:Leptin / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D009092:Mucous Membrane / Q000378:metabolism / Q000473:pathology; D001743:Urinary Bladder / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D053201:Urinary Bladder, Overactive / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D015431:Weight Loss
chemical_list: D004967:Estrogens; D020738:Leptin; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
keywords: dysuria; overactive bladder; secondary amenorrhea; weight loss