title: Protein-Protein Interface and Disease: Perspective from Biomolecular Networks.
abstract: Protein-protein interactions are involved in many important biological processes and molecular mechanisms of disease association. Structural studies of interfacial residues in protein complexes provide information on protein-protein interactions. Characterizing protein-protein interfaces, including binding sites and allosteric changes, thus pose an imminent challenge. With special focus on protein complexes, approaches based on network theory are proposed to meet this challenge. In this review we pay attention to protein-protein interfaces from the perspective of biomolecular networks and their roles in disease. We first describe the different roles of protein complexes in disease through several structural aspects of interfaces. We then discuss some recent advances in predicting hot spots and communication pathway analysis in terms of amino acid networks. Finally, we highlight possible future aspects of this area with respect to both methodology development and applications for disease treatment.
authors.affiliation: Center for Systems Biology, School of Electronic and Information Engineering, Soochow University, Suzhou, 215006, China. huguang@suda.edu.cn.
authors.forename: Guang
authors.initials: G
authors.lastname: Hu
authors.affiliation: School of Basic Medicine and Biological Sciences, Medical College of Soochow University, Suzhou, 215123, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Xiao
authors.affiliation: School of Electronic Engineering, University of Electronic Science and Technology of China, Chengdu, 611731, China.
authors.forename: Yuqian
authors.initials: Y
authors.lastname: Li
authors.affiliation: Center for Systems Biology, School of Electronic and Information Engineering, Soochow University, Suzhou, 215006, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Zoology, Faculty of Science, Kasetsart University, Bangkok, 10900, Thailand. wanwipa.v@ku.ac.th.|Computational Biomodelling Laboratory for Agricultural Science and Technology (CBLAST), Faculty of Science, Kasetsart University, Bangkok, 10900, Thailand. wanwipa.v@ku.ac.th.
authors.forename: Wanwipa
authors.initials: W
authors.lastname: Vongsangnak
mesh_terms: D000818:Animals; D001665:Binding Sites; D015415:Biomarkers / Q000737:chemistry / Q000378:metabolism; D003198:Computer Simulation; D004194:Disease; D006801:Humans; D053858:Metabolic Networks and Pathways; D008954:Models, Biological; D011485:Protein Binding; D025941:Protein Interaction Mapping / Q000379:methods*; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D015415:Biomarkers; D011506:Proteins
keywords: Amino acid network; Biomolecular network; Communication pathway; Disease; Hot spots; Protein–protein interaction