title: Intestinal permeability in a patient with liver cirrhosis.
abstract: Liver cirrhosis is a worldwide public health problem, and patients with this disease are at high risk of developing complications, bacterial translocation from the intestinal lumen to the mesenteric nodes, and systemic circulation, resulting in the development of severe complications related to high mortality rate. The intestinal barrier is a structure with a physical and biochemical activity to maintain balance between the external environment, including bacteria and their products, and the internal environment. Patients with liver cirrhosis develop a series of alterations in different components of the intestinal barrier directly associated with the severity of liver disease that finally increased intestinal permeability. A "leaky gut" is an effect produced by damaged intestinal barrier; alterations in the function of tight junction proteins are related to bacterial translocation and their products. Instead, increasing serum proinflammatory cytokines and hemodynamics modification, which results in the appearance of complications of liver cirrhosis such as hepatic encephalopathy, variceal hemorrhage, bacterial spontaneous peritonitis, and hepatorenal syndrome. The intestinal microbiota plays a fundamental role in maintaining the proper function of the intestinal barrier; bacterial overgrowth and dysbiosis are two phenomena often present in people with liver cirrhosis favoring bacterial translocation. Increased intestinal permeability has an important role in the genesis of these complications, and treating it could be the base for prevention and partial treatment of these complications.
authors.affiliation: Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición"Salvador Zubirán.
authors.forename: Jonathan Manuel
authors.initials: JM
authors.lastname: Aguirre Valadez
authors.affiliation: Pharmacology Laboratory, Instituto Nacional de Pediatría, Mexico City, Mexico.
authors.forename: Liliana
authors.initials: L
authors.lastname: Rivera-Espinosa
authors.affiliation: Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición"Salvador Zubirán.
authors.forename: Osvely
authors.initials: O
authors.lastname: Méndez-Guerrero
authors.affiliation: Pharmacology Laboratory, Instituto Nacional de Pediatría, Mexico City, Mexico.
authors.forename: Juan Luis
authors.initials: JL
authors.lastname: Chávez-Pacheco
authors.affiliation: Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición"Salvador Zubirán.
authors.forename: Ignacio
authors.initials: I
authors.lastname: García Juárez
authors.affiliation: Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición"Salvador Zubirán.
authors.forename: Aldo
authors.initials: A
authors.lastname: Torre
keywords: bacterial translocation; hepatic encephalopathy; intestinal permeability; liver cirrhosis; spontaneous bacterial peritonitis; variceal hemorrhage