title: Two new phenylpropanoids from Swertia atroviolacea and their anti-5α-reductase activity.
abstract: Two new phenylpropanoids (1-2), together with two known lignans (3-4), were isolated from whole herb of Swertia atroviolacea. The structures of the new metabolites were established on the basis of detailed spectroscopic analysis. Compounds 1 and 2 were evaluated for their anti-5α-reductase activity. The results revealed that 1 and 2 showed weak activity with reductase inhibitions of 45.6 ± 2.8% and 38.4 ± 2.5%, respectively.
authors.affiliation: a Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education , Yunnan Minzu University , Kunming , P.R. China.
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Wu
authors.affiliation: a Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education , Yunnan Minzu University , Kunming , P.R. China.
authors.forename: Xue-Qing
authors.initials: XQ
authors.lastname: Kan
authors.affiliation: a Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education , Yunnan Minzu University , Kunming , P.R. China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Sheng
authors.affiliation: a Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education , Yunnan Minzu University , Kunming , P.R. China.
authors.forename: Lin-Yun
authors.initials: LY
authors.lastname: Mou
authors.affiliation: a Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education , Yunnan Minzu University , Kunming , P.R. China.
authors.forename: Qing-Song
authors.initials: QS
authors.lastname: Yang
authors.affiliation: a Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education , Yunnan Minzu University , Kunming , P.R. China.
authors.forename: Qiu-Feng
authors.initials: QF
authors.lastname: Hu
authors.affiliation: a Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education , Yunnan Minzu University , Kunming , P.R. China.
authors.forename: Gan-Peng
authors.initials: GP
authors.lastname: Li
mesh_terms: D058891:5-alpha Reductase Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D017705:Lignans / Q000302:isolation & purification; D010666:Phenylpropionates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029967:Swertia / Q000737:chemistry*
chemical_list: D058891:5-alpha Reductase Inhibitors; D017705:Lignans; D010666:Phenylpropionates; C000620012:atroviolacin A; C000620014:atroviolacin B
keywords: Swertia atroviolacea; anti-5α-reductase activity; phenylpropanoids