title: The Borg family of Cdc42 effector proteins Cdc42EP1-5.
abstract: Despite being discovered more than 15 years ago, the Borg (binder of Rho GTPases) family of Cdc42 effector proteins (Cdc42EP1-5) remains largely uncharacterised and relatively little is known about their structure, regulation and role in development and disease. Recent studies are starting to unravel some of the key functional and mechanistic aspects of the Borg proteins, including their role in cytoskeletal remodelling and signalling. In addition, the participation of Borg proteins in important cellular processes such as cell shape, directed migration and differentiation is slowly emerging, directly linking Borgs with important physiological and pathological processes such as angiogenesis, neurotransmission and cancer-associated desmoplasia. Here, we review some of these findings and discuss future prospects.
authors.affiliation: Tumour Microenvironment Team, Division of Cancer Biology, Institute of Cancer Research, 237 Fulham Road, London SW2 6JB, U.K.
authors.forename: Aaron J
authors.initials: AJ
authors.lastname: Farrugia
authors.affiliation: Tumour Microenvironment Team, Division of Cancer Biology, Institute of Cancer Research, 237 Fulham Road, London SW2 6JB, U.K.
authors.forename: Fernando
authors.initials: F
authors.lastname: Calvo
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics / Q000378:metabolism*; D003598:Cytoskeletal Proteins; D003599:Cytoskeleton / Q000378:metabolism; D020555:GTP-Binding Protein Regulators / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D005810:Multigene Family; D016601:RNA-Binding Proteins; D015398:Signal Transduction; D020741:rho GTP-Binding Proteins
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C422984:CDC42EP2 protein, human; C484093:CDC42EP3 protein, human; C422985:CDC42EP4 protein, human; C484094:CDC42EP5 protein, human; D003598:Cytoskeletal Proteins; D020555:GTP-Binding Protein Regulators; D016601:RNA-Binding Proteins; C075598:CDC42EP1 protein, human; D020741:rho GTP-Binding Proteins
keywords: Borg; Cdc42; Rho GTPases; cytoskeleton; septin