title: Targeting Immune Suppression in Cancer.
abstract: Researchers have figured out a way to switch the immunosuppressive phenotype of tumor-associated macrophages to one that's immunostimulatory. By inhibiting PI3Kγ in these macrophages, they significantly suppressed tumor growth in mice; when anti-PD-1 therapy was added to PI3Kγ inhibition, complete and sustained tumor eradication was observed in many cases.
mesh_terms: D000818:Animals; D000072645:Cancer-Associated Fibroblasts / Q000276:immunology*; D002294:Carcinoma, Squamous Cell / Q000276:immunology*; D058544:Class Ib Phosphatidylinositol 3-Kinase / Q000172:deficiency; D016207:Cytokines / Q000378:metabolism*; D006258:Head and Neck Neoplasms / Q000276:immunology*; D006801:Humans; D051379:Mice; D009368:Neoplasm Transplantation; D011379:Prognosis; D016019:Survival Analysis; D059016:Tumor Microenvironment
chemical_list: D016207:Cytokines; D058544:Class Ib Phosphatidylinositol 3-Kinase; C546760:PIK3CG protein, human