title: Novel biomarkers in kidney disease: roles for cilia, Wnt signalling and ATMIN in polycystic kidney disease.
abstract: Biomarkers, the measurable indicators of biological conditions, are fast becoming a popular approach in providing information to track disease processes that could lead to novel therapeutic interventions for chronic conditions. Inherited, chronic kidney disease affects millions of people worldwide and although pharmacological treatments exist for some conditions, there are still patients whose only option is kidney dialysis and kidney transplantation. In the past 10 years, certain chronic kidney diseases have been reclassified as ciliopathies. Cilia in the kidney are antenna-like, sensory organelles that are required for signal transduction. One of the signalling pathways that requires the primary cilium in the kidney is Wnt signalling and it has three components such as canonical Wnt, non-canonical Wnt/planar cell olarity (PCP) and non-canonical Wnt/Ca2+signalling. Identification of the novel role of ATM INteractor (ATMIN) as an effector molecule in the non-canonical Wnt/PCP pathway has intrigued us to investigate its potential role in chronic kidney disease. ATMIN could thus be an important biomarker in disease prognosis and treatment that might lighten the burden of chronic kidney disease and also affect on its progression.
authors.affiliation: Faculty of Science, Engineering and Computing, Kingston University, Kingston upon Thames KT1 2EE, U.K.|Centre for Nephrology, University College London, Royal Free Campus NW3 2PF, U.K.
authors.forename: Paraskevi
authors.initials: P
authors.lastname: Goggolidou
authors.affiliation: Centre for Nephrology, University College London, Royal Free Campus NW3 2PF, U.K.
authors.forename: Patricia D
authors.initials: PD
authors.lastname: Wilson
mesh_terms: D015415:Biomarkers / Q000378:metabolism*; D002923:Cilia / Q000378:metabolism*; D018450:Disease Progression; D006801:Humans; D007674:Kidney Diseases / Q000378:metabolism* / Q000628:therapy; D008954:Models, Biological; D007690:Polycystic Kidney Diseases / Q000378:metabolism* / Q000628:therapy; D011379:Prognosis; D014157:Transcription Factors / Q000378:metabolism*; D060449:Wnt Signaling Pathway
chemical_list: C522841:ATMIN protein, human; D015415:Biomarkers; D014157:Transcription Factors
keywords: ATMIN; Wnt proteins; cilia; polycystic kidney disease