title: Histopathological features of middle cerebral artery and superficial temporal artery from patients with moyamoya disease and enlightenments on clinical treatment.
abstract: The histopathological features of the middle cerebral artery (MCA) and superficial temporal artery (STA) from moyamoya disease (MMD) and their relationships with gender, age, angiography stage were explored. The causes and the clinical significance of vasculopathy of STA were also discussed. The clinical data and specimens of MCA and STA from 30 MMD patients were collected. Twelve samples of MCA and STA from non-MMD patients served as control group. Histopathological examination was then performed by measuring the thickness of intima and media, and statistical analysis was conducted. The MCA and STA specimens from MMD group had apparently thicker intima and thinner media than those from the control group. There was no significant pathological difference between the hemorrhage group and non-hemorrhage group, and between the males and females in MMD patients. Neither the age nor the digital subtraction angiography (DSA) stage was correlated with the thickness of intima in MCA and STA. MMD is a systemic vascular disease involving both intracranial and extracranial vessels. Preoperative external carotid arteriography, especially super-selective arteriography of the STA, benefits the selection of donor vessel.
authors.affiliation: Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
authors.forename: Shou-Jia
authors.initials: SJ
authors.lastname: Sun
authors.affiliation: Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.|Department of Neurosurgery, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China.
authors.forename: Jian-Jian
authors.initials: JJ
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China.
authors.forename: Zheng-Wei
authors.initials: ZW
authors.lastname: Li
authors.affiliation: Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.|Department of Neurosurgery, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China.
authors.forename: Zhong-Wei
authors.initials: ZW
authors.lastname: Xiong
authors.affiliation: Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.|Department of Neurosurgery, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China.
authors.forename: Xiao-Lin
authors.initials: XL
authors.lastname: Wu
authors.affiliation: Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Shu
authors.affiliation: Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. chenjincao2012@hotmail.com.|Department of Neurosurgery, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China. chenjincao2012@hotmail.com.
authors.forename: Jin-Cao
authors.initials: JC
authors.lastname: Chen
mesh_terms: D000328:Adult; D000792:Angiography; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020768:Middle Cerebral Artery / Q000000981:diagnostic imaging / Q000473:pathology*; D009072:Moyamoya Disease / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D013699:Temporal Arteries / Q000000981:diagnostic imaging / Q000473:pathology*; D017539:Tunica Intima / Q000000981:diagnostic imaging / Q000473:pathology
keywords: middle cerebral artery; moyamoya disease; superficial temporal artery; vasculopathy