title: Aspirin-Based Carbon Dots, a Good Biocompatibility of Material Applied for Bioimaging and Anti-Inflammation.
abstract: The emerging photoluminescent carbon-based nanomaterials are promising in various fields besides cell imaging and carrier transport. Carbon nanomaterials with specific biological functions, however, are rarely investigated. Aspirin is a very common anti-inflammatory medication to relieve aches and pains. In this study, we have tried to create a carbon nanoparticle with aspirin, and we expect that this new carbon nanoparticle will have both anti-inflammatory and fluorescent biomarker functions. Fluorescent aspirin-based carbon dots (FACDs) were synthesized by condensing aspirin and hydrazine through a one-step microwave-assisted method. Imaging data demonstrated that FACDs efficiently entered into human cervical carcinoma and mouse monocyte macrophage cells in vitro with low cell toxicity. Results from quantitative polymerase chain reaction and histological analysis indicated that FACDs possessed effective anti-inflammatory effects in vitro and in vivo compared to aspirin only. Hematology, serum biochemistry, and histology results suggested that FACDs also had no significant toxicity in vivo. Our results clearly demonstrate that FACDs have dual functions, cellular imaging/bioimaging and anti-inflammation, and suggest that FACDs have great potential in future clinical applications.
authors.affiliation: Department of Oral Pathology, School and Hospital of Stomatology, Jilin University , Changchun 130021, P. R. China.|Department of Periodontology, School and Hospital of Stomatology, Jilin University , Changchun 130021, P. R. China.|Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Jilin University , Changchun 130021, P. R. China.|State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University , Changchun 130012, P. R. China.
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Xu
authors.affiliation: State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University , Changchun 130012, P. R. China.
authors.forename: Kai
authors.initials: K
authors.lastname: Zhang
authors.affiliation: Department of Oral Pathology, School and Hospital of Stomatology, Jilin University , Changchun 130021, P. R. China.
authors.forename: Liang
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Department of Oral Medicine, School and Hospital of Stomatology, Jilin University , Changchun 130021, P. R. China.
authors.forename: Chen
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Oral Pathology, School and Hospital of Stomatology, Jilin University , Changchun 130021, P. R. China.
authors.forename: Wenhuan
authors.initials: W
authors.lastname: Bu
authors.affiliation: Department of Periodontology, School and Hospital of Stomatology, Jilin University , Changchun 130021, P. R. China.
authors.forename: Yuqin
authors.initials: Y
authors.lastname: Shen
authors.affiliation: Department of Periodontology, School and Hospital of Stomatology, Jilin University , Changchun 130021, P. R. China.
authors.forename: Zhongyi
authors.initials: Z
authors.lastname: Gu
authors.affiliation: Department of Oral Pathology, School and Hospital of Stomatology, Jilin University , Changchun 130021, P. R. China.
authors.forename: Bei
authors.initials: B
authors.lastname: Chang
authors.affiliation: Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health , Bethesda, Maryland 20892, United States.
authors.forename: Changyu
authors.initials: C
authors.lastname: Zheng
authors.affiliation: Department of Periodontology, School and Hospital of Stomatology, Jilin University , Changchun 130021, P. R. China.
authors.forename: Chongtao
authors.initials: C
authors.lastname: Lin
authors.affiliation: Department of Oral Pathology, School and Hospital of Stomatology, Jilin University , Changchun 130021, P. R. China.|Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Jilin University , Changchun 130021, P. R. China.|State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University , Changchun 130012, P. R. China.
authors.forename: Hongchen
authors.initials: H
authors.lastname: Sun
authors.affiliation: State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University , Changchun 130012, P. R. China.
authors.forename: Bai
authors.initials: B
authors.lastname: Yang
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000737:chemistry*; D001241:Aspirin / Q000008:administration & dosage / Q000737:chemistry*; D001672:Biocompatible Materials / Q000008:administration & dosage / Q000737:chemistry; D001854:Bone Marrow Cells / Q000187:drug effects; D002244:Carbon / Q000008:administration & dosage / Q000737:chemistry*; D003952:Diagnostic Imaging / Q000379:methods; D004195:Disease Models, Animal; D005456:Fluorescent Dyes / Q000008:administration & dosage / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy; D007624:KB Cells; D008297:Male; D051379:Mice; D008819:Mice, Nude; D045663:Quantum Dots / Q000008:administration & dosage / Q000737:chemistry*; D000067996:RAW 264.7 Cells; D011897:Random Allocation; D017208:Rats, Wistar; D017154:Stromal Cells / Q000187:drug effects
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001672:Biocompatible Materials; D005456:Fluorescent Dyes; D002244:Carbon; D001241:Aspirin
keywords: anti-inflammation; aspirin; biocompatibility; bioimaging; carbon dots