title: Dating the Heart: Exploring Cardiomyocyte Renewal in Humans.
abstract: Regenerative mechanisms reported in the hearts of lower vertebrates have been recapitulated in the mammalian milieu, and recent studies have provided strong evidence for cardiomyocyte turnover in humans. These findings speak to an emerging consensus that adult mammalian cardiomyocytes do have the ability to divide, and it stands to reason that enrichment of this innate proliferative capacity should prove essential for complete cardiac regeneration.
authors.affiliation: Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden; and.
authors.forename: Evan
authors.initials: E
authors.lastname: Graham
authors.affiliation: Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden; and.|DFG Research Center for Regenerative Therapies, Technische Universität Dresden, Dresden, Germany.
authors.forename: Olaf
authors.initials: O
authors.lastname: Bergmann
mesh_terms: D000818:Animals; D002250:Carbon Radioisotopes; D049109:Cell Proliferation / Q000528:radiation effects; D004195:Disease Models, Animal; D006321:Heart / Q000502:physiology* / Q000528:radiation effects; D006333:Heart Failure / Q000503:physiopathology; D006801:Humans; D051379:Mice; D032383:Myocytes, Cardiac / Q000502:physiology* / Q000528:radiation effects; D055110:Radiometric Dating; D012038:Regeneration / Q000528:radiation effects
chemical_list: D002250:Carbon Radioisotopes