title: Polymorphisms of Promoter Region of TNF-α Gene in Iranian Azeri Turkish Patients with Behçet's Disease.
abstract: Behçet's disease (BD) is a complex chronic relapsing inflammatory disorder of unknown etiology. Alterations of the tumor necrosis factor (TNF) expression related to the polymorphic alleles of TNF gene may implicate a pathogenetic role in increased activity of this cytokine in BD. A current study aimed at investigating the possible association between BD and its clinical features in Iranian Azeri Turks with two functional TNF-α gene polymorphisms (at the positions of -238 and -857). A total number of 166 Iranian subjects were enrolled into two different groups; patients with BD (n = 64), and ethnically matched healthy controls (n = 101). The genotype distributions of BD patients and healthy controls were determined. The frequency of TNF-α -857C allele was significantly higher in Behçet's patients than that of healthy controls (P = 0.001; odds ratio [OR] = 2.616; 95% confidence interval [CI] = 1.129-6.160), whereas the frequency of TNF-α -238A allele was similar in both groups. The sole TNF-α haplotype-857C-1031C, was associated with an increase in the risk of developing BD. The TNF-α -857C allele was considerably associated with BD in this cohort. The findings of this study, collectively, indicate that TNF-α -857C-1031C haplotype located in the promoter region of the gene could exert major influence on the susceptibility to BD.
authors.affiliation: Liver & Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.|Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
authors.forename: Reza
authors.identifier: http://orcid.org/0000-0002-6670-6781
authors.initials: R
authors.lastname: Abdolmohammadi
authors.affiliation: Liver & Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.|Department of Molecular-Medical Genetics, Center of Excellence for Biodiversity, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran. Jabbarpour@tabrizu.ac.ir.
authors.forename: Mortaza
authors.identifier: http://orcid.org/0000-0003-3216-2947
authors.initials: M
authors.lastname: Bonyadi
mesh_terms: D000328:Adult; D000483:Alleles; D001528:Behcet Syndrome / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006720:Homozygote; D006801:Humans; D007492:Iran; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D014409:Tumor Necrosis Factor-alpha
keywords: Behçet's Disease; Iranian Azeri Turks; Polymorphism; Tumor Necrosis Factor-α