title: The Analgesic Effect of Ropivacaine Combined With Dexmedetomidine for Incision Infiltration After Laparoscopic Cholecystectomy.
abstract: BACKGROUND
  Local anesthetics infiltration is one consensus efficient strategy for pain relief after laparoscopic cholecystectomy (LC). The aim of this study was to investigate analgesia efficacy of incisional infiltration with ropivacaine plus dexmedetomidine.
  
  
  METHODS
  Patients scheduled for LC were assigned to 4 groups by different medications for trocar wound infiltration. The incidence of adverse events and the analgesic effect of ropivacaine combined with dexmedetomidine for incision infiltration were recorded.
  
  
  RESULTS
  Incisional infiltration of ropivacaine combining with dexmedetomidine could significantly reduce postoperative pain and the amount of pethidine requirement. Furthermore, it could also reduce time to walk without assistance, improve the efficacy of analgesia and sleep quality during the first night after LC, but did not increase the incidence of surgical adverse events.
  
  
  CONCLUSIONS
  The use of ropivacaine and dexmedetomidine may be considered as an alternative treatment for postoperative pain in patients undergoing LC.
authors.affiliation: *Department of Anesthesiology, The First People's Hospital of Hefei, Anhui Medical University †Department of Anesthesiology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
authors.forename: Jun-Ma
authors.initials: JM
authors.lastname: Yu
authors.forename: Hao
authors.initials: H
authors.lastname: Sun
authors.forename: Chao
authors.initials: C
authors.lastname: Wu
authors.forename: Chun-Shan
authors.initials: CS
authors.lastname: Dong
authors.forename: Yao
authors.initials: Y
authors.lastname: Lu
authors.forename: Ye
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000577:Amides / Q000008:administration & dosage*; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage; D000772:Anesthesia, Local / Q000379:methods*; D000779:Anesthetics, Local / Q000008:administration & dosage; D017081:Cholecystectomy, Laparoscopic; D020927:Dexmedetomidine / Q000008:administration & dosage*; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D005705:Gallbladder Diseases / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D010149:Postoperative Pain / Q000175:diagnosis / Q000188:drug therapy*; D011182:Postoperative Care / Q000379:methods*; D012189:Retrospective Studies; D000077212:Ropivacaine; D016896:Treatment Outcome
chemical_list: D000577:Amides; D018712:Analgesics, Non-Narcotic; D000779:Anesthetics, Local; D020927:Dexmedetomidine; D000077212:Ropivacaine