title: Cytotoxic coumaronochromones from the inflorescences of Celosia cristata.
abstract: Investigation on the MeOH extracts of the inflorescences of Celosia cristata led to the isolation of two new coumaronochromones, cristatone I (1) and cristatone II (2), along with three known flavones (3-5). Their structures were elucidated on the basis of spectroscopic analyses. Compounds 1-5 were tested for their cytotoxic activity against HeLa and BGC-823 cancer cell lines, of which cristatone II (2) showed interesting activity with the IC50value of 23.82 μM.
authors.affiliation: a College of Plant Protection , Northwest A&F University , Yangling , China.
authors.forename: He
authors.initials: H
authors.lastname: Yan
authors.affiliation: b College of Animal Science and Techenology , Northwest A&F University , Yangling , China.
authors.forename: Gonghai
authors.initials: G
authors.lastname: Zhang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D001572:Benzofurans / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D034762:Celosia / Q000737:chemistry*; D002867:Chromones / Q000737:chemistry / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D047309:Flavones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D056626:Inflorescence / Q000737:chemistry; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001572:Benzofurans; D002867:Chromones; D047309:Flavones; D010936:Plant Extracts; C000625988:cristatone II
keywords: Celosia cristata; coumaronochromones; cristatone I; cristatone II