title: Neuroprotection and secondary damage following spinal cord injury: concepts and methods.
abstract: Neuroprotection refers to the attenuation of pathophysiological processes triggered by acute injury to minimize secondary damage. The development of neuroprotective treatments represents a major goal in the field of spinal cord injury (SCI) research. In this review, we discuss the strengths and limitations of the methodologies employed to assess secondary damage and neuroprotection in preclinical models of traumatic SCI. We also discuss modelling issues and how new tools might be exploited to study secondary damage and neuroprotection.
authors.affiliation: International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada; Department of Zoology, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.
authors.forename: Brett J
authors.initials: BJ
authors.lastname: Hilton
authors.affiliation: International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada; Department of Zoology, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.
authors.forename: Aaron J
authors.initials: AJ
authors.lastname: Moulson
authors.affiliation: International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada; Department of Zoology, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada; Department of Surgery, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada. Electronic address: tetzlaff@icord.org.
authors.forename: Wolfram
authors.initials: W
authors.lastname: Tetzlaff
mesh_terms: D000200:Action Potentials; D000818:Animals; D004195:Disease Models, Animal; D009474:Neurons / Q000473:pathology; D000066829:Neuroprotection; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D013119:Spinal Cord Injuries / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology
chemical_list: D018696:Neuroprotective Agents
keywords: CNS injury; Neuroprotection; Secondary damage; Spinal cord injury