title: Secondary Neuroendocrine Carcinoma Following High-Dose Radiotherapy for Head and Neck Cancer: Report of Two Cases.
abstract: Patients treated with radiation have an increased risk of developing second cancers, of which carcinomas, sarcomas, and hematological malignancies have most commonly been reported. Neuroendocrine carcinomas (NEC) are rarely reported in patients previously treated with radiation. Two patients, who had successfully undergone chemoradiotherapy for head and neck cancers at our institution, developed secondary NEC within the radiation field more than five years after the treatment. Both patients underwent curative-intent treatment of secondary malignancies, one with chemotherapy, radiation and surgery (Case 1) and the other with chemotherapy and surgery (Case 2). Both had no evidence of disease at a short follow-up of twelve months (Case 1), and three months (Case 2) after treatment. NEC can develop post-radiotherapy; a multidisciplinary approach is necessary to successfully treat these patients.
authors.affiliation: Radiation Oncology, Memorial Sloan-Kettering Cancer Center ; Radiation Oncology, University of Calgary/Tom Baker Cancer Center.
authors.forename: Amandeep S
authors.initials: AS
authors.lastname: Taggar
authors.affiliation: Department of Pathology, University of Calgary.
authors.forename: Roderick
authors.initials: R
authors.lastname: Simpson
authors.affiliation: Medical Oncology, University of Calgary.
authors.forename: Desiree
authors.initials: D
authors.lastname: Hao
authors.affiliation: Medical Oncology, University of Calgary.
authors.forename: Marc
authors.initials: M
authors.lastname: Webster
authors.affiliation: Department of Pathology, University of Calgary.
authors.forename: Moosa
authors.initials: M
authors.lastname: Khalil
authors.affiliation: Department of Diagnostic Imaging, University of Calgary.
authors.forename: John
authors.initials: J
authors.lastname: Lysack
authors.affiliation: Medical Oncology, University of Calgary.
authors.forename: David
authors.initials: D
authors.lastname: Skarsgard
keywords: head and neck; neuroendocrine; radiation; secondary cancer