title: Inverse hexagonal and cubic micellar lyotropic liquid crystalline phase behaviour of novel double chain sugar-based amphiphiles.
abstract: The lyotropic phase behaviour of a library of sugar-based amphiphiles was investigated using high-throughput small-angle X-ray scattering (SAXS). Double unsaturated-chain monosaccharide amphiphiles formed inverse hexagonal and cubic micellar (Fd3m) lyotropic phases under excess water conditions. A galactose-oleyl amphiphile from the library was subsequently formulated into hexosome nanoparticles, which have potential uses as drug delivery vehicles. The nanoparticles were shown to be stable at elevated temperatures and non-cytotoxic up to at least 200μgmL-1.
authors.affiliation: CSIRO Manufacturing, Bag 10, Clayton South MDC, VIC, 3169, Australia.
authors.forename: George C
authors.initials: GC
authors.lastname: Feast
authors.affiliation: CSIRO Manufacturing, Bag 10, Clayton South MDC, VIC, 3169, Australia.
authors.forename: Thomas
authors.initials: T
authors.lastname: Lepitre
authors.affiliation: School of Science, College of Science, Engineering and Health, RMIT University, GPO Box 2476, Melbourne, VIC, 3001, Australia.
authors.forename: Nhiem
authors.initials: N
authors.lastname: Tran
authors.affiliation: School of Science, College of Science, Engineering and Health, RMIT University, GPO Box 2476, Melbourne, VIC, 3001, Australia.
authors.forename: Charlotte E
authors.initials: CE
authors.lastname: Conn
authors.affiliation: CSIRO Manufacturing, Bag 10, Clayton South MDC, VIC, 3169, Australia.
authors.forename: Oliver E
authors.initials: OE
authors.lastname: Hutt
authors.affiliation: CSIRO Manufacturing, Bag 10, Clayton South MDC, VIC, 3169, Australia.
authors.forename: Xavier
authors.initials: X
authors.lastname: Mulet
authors.affiliation: CSIRO Manufacturing, Bag 10, Clayton South MDC, VIC, 3169, Australia; School of Science, College of Science, Engineering and Health, RMIT University, GPO Box 2476, Melbourne, VIC, 3001, Australia. Electronic address: calum.drummond@rmit.edu.au.
authors.forename: Calum J
authors.initials: CJ
authors.lastname: Drummond
authors.affiliation: CSIRO Manufacturing, Bag 10, Clayton South MDC, VIC, 3169, Australia.
authors.forename: G Paul
authors.initials: GP
authors.lastname: Savage
mesh_terms: D000818:Animals; D002460:Cell Line; D002470:Cell Survival; D004305:Dose-Response Relationship, Drug; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D005690:Galactose / Q000737:chemistry; D005947:Glucose / Q000737:chemistry; D007785:Lactose / Q000737:chemistry; D050866:Liquid Crystals; D008358:Mannose / Q000737:chemistry; D051379:Mice; D008823:Micelles; D053758:Nanoparticles / Q000737:chemistry*; D012542:Scattering, Radiation; D053838:Scattering, Small Angle; D013696:Temperature; D014867:Water / Q000737:chemistry; D014965:X-Rays; D014994:Xylose / Q000737:chemistry
chemical_list: D004337:Drug Carriers; D008823:Micelles; D014867:Water; D014994:Xylose; D005947:Glucose; D007785:Lactose; D008358:Mannose; D005690:Galactose
keywords: Amphiphiles; Fd3m; Hexagonal phase; Hexosome; Self-assembly; Sugars