title: Prevalence of obesity and risk of chronic kidney disease among young adults in Egypt.
abstract: Increasing body mass index (BMI) has reached epidemic proportions globally and recently emerged as strong, independent risk factors for chronic kidney disease (CKD). We conducted this study to verify the prevalence of obesity and the associated risk of developing CKD among 3000 Egyptian students. The World Health Organization classification of BMI categorized study population into 1-5 groups, 1146 subjects with normal BMI (20-25), 951 subjects with BMI 25-29.9, 540 subjects with BMI 30-34.9, 225 with BMI 35-39.9, and 138 with BMI above 40. The participants were subjected to clinical examination, anthropometric measurements, laboratory investigation, including urinary albumin/creatinine ratio (ACR) and estimation of glomerular filtration rate (eGFR). The prevalence of overweight, obesity, and metabolic syndrome (MS) was 31.7%, 30.1%, and 16%, respectively. The prevalence of CKD among subjects with BMI >25 was 6.5%, almost all of them had BMI >35. ACR and eGFR rose progressively with increasing BMI. Elevated mean arterial pressure (MAP), high sensitivity C-reactive protein, and MS increased the risk of development of CKD. Moreover, MAP, waist to height ratio, and triglycerides to high-density lipoprotein ratios at levels of >95 mm Hg, >0.6, and >3 had sensitivity 91.7%, 88.4%, and 86.7%; and specificity 92.3%, 96.4%, and 96.5%, respectively to predict CKD. The prevalence of obesity among Egyptian young adults was high (30.1%) and was associated with increased the risk of CKD (6.5%).
authors.affiliation: Department of Nephrology, Zagazig University Hospital, Zagazig, Egypt.
authors.forename: M
authors.initials: M
authors.lastname: Fouad
authors.affiliation: Department of Nephrology, Zagazig University Hospital, Zagazig, Egypt.
authors.forename: M I
authors.initials: MI
authors.lastname: Ismail
authors.affiliation: Department of Clinical Pathology, Zagazig University Hospital, Zagazig, Egypt.
authors.forename: A
authors.initials: A
authors.lastname: Gaballah
authors.affiliation: Nephrology Unit, Mansoura General Hospital, Egypt.
authors.forename: E
authors.initials: E
authors.lastname: Reyad
authors.affiliation: Department of Nephrology, Zagazig University Hospital, Zagazig, Egypt.
authors.forename: S
authors.initials: S
authors.lastname: ELdeeb
keywords: Body mass index; chronic kidney disease; metabolic syndrome; urinary albumin/creatinine ratio