title: Dermatophagoides pteronyssinus: Changes in sensitisation in the past 11 years and comparison with other centres in Mexico.
abstract: BACKGROUND
  House dust mites are a ubiquitous air allergen in the human habitat. It has been shown that exposure to them is a fundamental factor in sensitisation and development of atopic disease. The objective of the study was to analyse changes in sensitisation to Dermatophagoides pteronyssinus (Der p.) in children treated in a tertiary level care hospital in Mexico City for a period of 11 years and compare with other studies carried out in Mexico.
  
  
  METHODS
  A retrospective study was performed at the Hospital Infantil de México Federico Gómez (HIMFG). Information was gathered from skin tests for Der p. performed in the Allergy Laboratory from January 2004 to April 2015. Patients 2-18 years old who presented for examination of some type of allergic condition and who had immediate hypersensitivity tests to Der p. were included in the study. Results were compared with prior reports from other institutions. Descriptive analysis and χ2statistics were used.
  
  
  RESULTS
  A total of 8794 patients were included in the study; 49.3% of the tests (95% CI 48-50) were positive for Der p. The percentage of monosensitised to mites was 2.7% for Der p. (95% CI 2-3). A significant difference was found between the results of older patients and those <6 years old. The frequency of sensitisation had a tendency to decrease during the 11 years analysed in all age groups.
  
  
  CONCLUSIONS
  The frequency of sensitisation to Der p. increased with age until reaching adolescence. In the last 11 years a decrease in sensitisation to this air allergen was observed.
authors.affiliation: Servicio de Alergia e Inmunología Clínica Pediátrica, Hospital Infantil de México Federico Gómez, México, DF, Mexico.
authors.forename: E M
authors.initials: EM
authors.lastname: Navarrete-Rodríguez
authors.affiliation: Servicio de Alergia e Inmunología Clínica Pediátrica, Hospital Infantil de México Federico Gómez, México, DF, Mexico.
authors.forename: J R
authors.initials: JR
authors.lastname: Fernández-Soto
authors.affiliation: Servicio de Alergia e Inmunología Clínica Pediátrica, Hospital Infantil de México Federico Gómez, México, DF, Mexico. Electronic address: blancadelrionavarro@gmail.com.
authors.forename: B E
authors.initials: BE
authors.lastname: Del Rio-Navarro
authors.affiliation: Servicio de Alergia e Inmunología Clínica Pediátrica, Hospital Infantil de México Federico Gómez, México, DF, Mexico.
authors.forename: O J
authors.initials: OJ
authors.lastname: Saucedo-Ramírez
authors.affiliation: Subdirección de Pediatria Ambulatoria, Hospital Infantil de México Federico Gómez, México, DF, Mexico.
authors.forename: J J L
authors.initials: JJ
authors.lastname: Sienra-Monge
mesh_terms: D000293:Adolescent; D000818:Animals; D039741:Antigens, Dermatophagoides / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D040002:Dermatophagoides pteronyssinus / Q000276:immunology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology* / Q000276:immunology; D007114:Immunization; D008297:Male; D008800:Mexico; D012189:Retrospective Studies; D062606:Tertiary Care Centers; D013997:Time Factors
chemical_list: D039741:Antigens, Dermatophagoides
keywords: Dermatophagoides; Prick test; Sensitization