title: The Generalized Relative Pairs IBD Distribution: Its Use in the Detection of Linkage.
abstract: I introduce a novel approach to derive the distribution of disease affectional status given allelesidentical by descent(IBD) sharing throughITOmethod. My approach tremendously simplifies the calculation of the affectional status distribution compared to the conventional method, which requires the parental mating information, and could be applied to disease with both dichotomous trait andquantitative trait locus(QTL). This distribution is shown to be independent of relative relationship and be employed to develop the markerIBDdistributions for relative relationship. In addition, three linkage tests: the proportion, the mean test, and the LOD score test are proposed for different relative pairs based on their markerIBDdistributions. Among all three tests, the mean test for sib pair requires the least sample size, thus, has the highest power. Finally, I evaluate the significance of different relative relationships by a Monte-Carlo simulation approach.
authors.affiliation: Department of Statistics, The George Washington University , Washington, DC , USA.
authors.forename: Quan
authors.initials: Q
authors.lastname: Zou
keywords: ITO method; allele identical by descent; linkage analysis; quantitative trait locus; relative pairs