title: Cellular responses to replication stress: Implications in cancer biology and therapy.
abstract: DNA replication is essential for cell proliferation. Any obstacles during replication cause replication stress, which may lead to genomic instability and cancer formation. In this review, we summarize the physiological DNA replication process and the normal cellular response to replication stress. We also outline specialized therapies in clinical trials based on current knowledge and future perspectives in the field.
authors.affiliation: The Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: hhsieh@mdanderson.org.
authors.forename: Hui-Ju
authors.initials: HJ
authors.lastname: Hsieh
authors.affiliation: The Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
authors.forename: Guang
authors.initials: G
authors.lastname: Peng
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004249:DNA Damage; D004260:DNA Repair; D004261:DNA Replication; D042822:Genomic Instability; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents
keywords: Cancer; Clinical trials; DNA replication; Genomic instability; Replication stress