title: Antimicrobial photodynamic therapy vs. local minocycline in addition to non-surgical therapy of deep periodontal pockets: a controlled randomized clinical trial.
abstract: OBJECTIVE
  To investigate the additional influence of either antimicrobial photodynamic therapy (aPDT; Helbo® Photodynamic Systems) or local application of minocycline microspheres (MC; Arestin, OraPharma) on clinical and microbiological healing results in deep periodontal pockets (PPD ≥6 mm) following non-surgical periodontal therapy (SRP).
  
  
  METHODS
  Forty-five patients with chronic periodontitis were evaluated: test group aPDT + SRP (n = 15), positive control group MC + SRP (n = 15), and negative control group SRP-alone (n = 15). Clinical and microbiological healing parameters were recorded in every patient for four experimental teeth at baseline, 6 weeks, and 3, 6, and 12 months. Wilcoxon signed-rank test and Mann-Whitney U test were used for statistical analysis (α = 0.05).
  
  
  RESULTS
  Significant improvements in clinical and microbiological parameters were found for all groups after 6 weeks and 3, 6, and 12 months. Differences between groups were not statistically significant. Changes after 12 months [median (25/75%)] are as follows: reduction in PPD [mm]: aPDT + SRP 2 (1/3), MC + SRP 3 (1/4), SRP-alone 2 (1/3); percentage of residual BOP positive teeth [%]: aPDT + SRP 75 (25/100), MC + SRP 33.3 (0/50), SRP-alone 66.7 (25/75).
  
  
  CONCLUSIONS
  Within the limitations of this study, neither the applied aPDT system nor MC showed a significant additional influence on clinical and microbiological healing outcomes in deep periodontal pockets compared to SRP alone.
  
  
  CONCLUSIONS
  In deep periodontal defects, the efficacy of non-surgical periodontal treatment seems not to be improved by adjunctive use of antimicrobial photodynamic therapy or minocycline microspheres.
authors.affiliation: Department of Conservative Dentistry and Periodontology, University Medical Center Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany.
authors.forename: Laura
authors.initials: L
authors.lastname: Tabenski
authors.affiliation: Private Practice, 93051, Regensburg, Germany.
authors.forename: Daniel
authors.initials: D
authors.lastname: Moder
authors.affiliation: Department of Conservative Dentistry and Periodontology, University Medical Center Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany.
authors.forename: Fabian
authors.initials: F
authors.lastname: Cieplik
authors.affiliation: Private Practice, 93051, Regensburg, Germany.
authors.forename: Frederike
authors.initials: F
authors.lastname: Schenke
authors.affiliation: Department of Conservative Dentistry and Periodontology, University Medical Center Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany.
authors.forename: Karl-Anton
authors.initials: KA
authors.lastname: Hiller
authors.affiliation: Department of Conservative Dentistry and Periodontology, University Medical Center Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Buchalla
authors.affiliation: Department of Conservative Dentistry and Periodontology, University Medical Center Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany.|Department of Preventive, Restorative and Pediatric Dentistry, University School of Dental Medicine, Freiburgstraße 7, 3010, Bern, Switzerland.
authors.forename: Gottfried
authors.initials: G
authors.lastname: Schmalz
authors.affiliation: Department of Conservative Dentistry and Periodontology, University Medical Center Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany. michael.christgau@klinik.uni-regensburg.de.|Private Practice, 40545, Düsseldorf, Germany. michael.christgau@klinik.uni-regensburg.de.
authors.forename: Michael
authors.initials: M
authors.lastname: Christgau
mesh_terms: D000890:Anti-Infective Agents / Q000627:therapeutic use*; D055113:Chronic Periodontitis / Q000188:drug therapy* / Q000382:microbiology* / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D008863:Microspheres; D008875:Middle Aged; D008911:Minocycline / Q000627:therapeutic use*; D010514:Periodontal Pocket / Q000188:drug therapy* / Q000382:microbiology* / Q000628:therapy; D010778:Photochemotherapy / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D000890:Anti-Infective Agents; D008911:Minocycline
keywords: Antimicrobial photodynamic therapy; Local antibiotics; Minocycline; Non-surgical periodontal therapy; Scaling and root planing