title: Construct Validity of Radiographs of the Feet to Assess Joint Damage in Patients with Gout.
abstract: To investigate construct validity of radiographic damage of the feet in gout.
  
  
  
  Radiographs of the feet were scored using the Sharp/van der Heijde method. Factors associated with damage were investigated by a negative binomial model, and contribution of damage to health by linear regressions.
  
  
  
  Age, disease duration, serum uric acid, and tophi were associated with being erosive and erosion score. Tophi were associated with joint space narrowing. Erosions were associated (β 0.47, 95% CI 0.09-0.84) with physical function, but damage was not associated with overall physical health.
  
  
  
  Our results support construct validity for radiographs of the feet when assessing joint damage in gout.
authors.affiliation: From the Department of Internal Medicine and Division of Rheumatology, and Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Center; Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, the Netherlands; Département de Médecine Physique, Centre Hospitalier Chrétien, Liège, Belgium. bartholomeus.spaetgens@mumc.nl.|B. Spaetgens, MD, Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, and CAPHRI, Maastricht University; C. van Durme, MD, Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, and Département de Médecine Physique, Centre Hospitalier Chrétien; C. Webers, MD, Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center; A. Tran-Duy, PhD, Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, and Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Center; T. Schoonbrood, MD, Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center; A. Boonen, MD, PhD, Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, and CAPHRI, Maastricht University. bartholomeus.spaetgens@mumc.nl.
authors.forename: Bart
authors.initials: B
authors.lastname: Spaetgens
authors.affiliation: From the Department of Internal Medicine and Division of Rheumatology, and Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Center; Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, the Netherlands; Département de Médecine Physique, Centre Hospitalier Chrétien, Liège, Belgium.|B. Spaetgens, MD, Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, and CAPHRI, Maastricht University; C. van Durme, MD, Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, and Département de Médecine Physique, Centre Hospitalier Chrétien; C. Webers, MD, Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center; A. Tran-Duy, PhD, Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, and Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Center; T. Schoonbrood, MD, Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center; A. Boonen, MD, PhD, Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, and CAPHRI, Maastricht University.
authors.forename: Caroline
authors.initials: C
authors.lastname: van Durme
authors.affiliation: From the Department of Internal Medicine and Division of Rheumatology, and Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Center; Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, the Netherlands; Département de Médecine Physique, Centre Hospitalier Chrétien, Liège, Belgium.|B. Spaetgens, MD, Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, and CAPHRI, Maastricht University; C. van Durme, MD, Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, and Département de Médecine Physique, Centre Hospitalier Chrétien; C. Webers, MD, Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center; A. Tran-Duy, PhD, Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, and Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Center; T. Schoonbrood, MD, Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center; A. Boonen, MD, PhD, Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, and CAPHRI, Maastricht University.
authors.forename: Casper
authors.initials: C
authors.lastname: Webers
authors.affiliation: From the Department of Internal Medicine and Division of Rheumatology, and Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Center; Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, the Netherlands; Département de Médecine Physique, Centre Hospitalier Chrétien, Liège, Belgium.|B. Spaetgens, MD, Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, and CAPHRI, Maastricht University; C. van Durme, MD, Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, and Département de Médecine Physique, Centre Hospitalier Chrétien; C. Webers, MD, Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center; A. Tran-Duy, PhD, Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, and Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Center; T. Schoonbrood, MD, Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center; A. Boonen, MD, PhD, Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, and CAPHRI, Maastricht University.
authors.forename: An
authors.initials: A
authors.lastname: Tran-Duy
authors.affiliation: From the Department of Internal Medicine and Division of Rheumatology, and Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Center; Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, the Netherlands; Département de Médecine Physique, Centre Hospitalier Chrétien, Liège, Belgium.|B. Spaetgens, MD, Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, and CAPHRI, Maastricht University; C. van Durme, MD, Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, and Département de Médecine Physique, Centre Hospitalier Chrétien; C. Webers, MD, Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center; A. Tran-Duy, PhD, Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, and Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Center; T. Schoonbrood, MD, Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center; A. Boonen, MD, PhD, Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, and CAPHRI, Maastricht University.
authors.forename: Thea
authors.initials: T
authors.lastname: Schoonbrood
authors.affiliation: From the Department of Internal Medicine and Division of Rheumatology, and Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Center; Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, the Netherlands; Département de Médecine Physique, Centre Hospitalier Chrétien, Liège, Belgium.|B. Spaetgens, MD, Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, and CAPHRI, Maastricht University; C. van Durme, MD, Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, and Département de Médecine Physique, Centre Hospitalier Chrétien; C. Webers, MD, Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center; A. Tran-Duy, PhD, Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, and Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Center; T. Schoonbrood, MD, Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center; A. Boonen, MD, PhD, Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, and CAPHRI, Maastricht University.
authors.forename: Annelies
authors.initials: A
authors.lastname: Boonen
mesh_terms: D000367:Age Factors; D000368:Aged; D018450:Disease Progression; D005260:Female; D005528:Foot / Q000000981:diagnostic imaging*; D033023:Foot Joints / Q000000981:diagnostic imaging*; D006073:Gout / Q000097:blood / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D012720:Severity of Illness Index; D014527:Uric Acid / Q000097:blood
chemical_list: D014527:Uric Acid
keywords: GOUT; IMAGING; PATIENT-REPORTED OUTCOME; QUALITY OF LIFE; RADIOGRAPHIC DAMAGE