title: Divergent Synthesis of Polymethoxylated 4-Aryl-2-quinolones.
abstract: Polymethoxylated 4-aryl-2-quinolones were synthesized from the corresponding (o-aminophenyl)propiolates via Cu-catalyzed hydroarylation and subsequent deprotection/lactam formation. Selective iodination of the C3 position of the product followed by coupling reactions of the resulting 3-iodinated 4-aryl-2-quinolone afforded 3-substituted-4-aryl-2-quinolones. Moreover, the N-benzyl protecting group was successfully replaced with other polyoxygenated benzyl groups.
authors.affiliation: Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University , Chikusa, Nagoya 464-8601, Japan.
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Murayama
authors.affiliation: Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University , Chikusa, Nagoya 464-8601, Japan.
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Shibuya
authors.affiliation: Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University , Chikusa, Nagoya 464-8601, Japan.
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Yamamoto