title: Hepatoid Carcinoma of the Pancreas: Case Report, Next-Generation Tumor Profiling, and Literature Review.
abstract: Fewer than 25 cases of hepatoid carcinoma of the pancreas have been reported in the literature. We present a case in a 61-year-old male with a remote history of Hodgkin's lymphoma and gastric neuroendocrine cell hyperplasia. On surveillance endoscopic ultrasound, an 8 × 5 mm cystic lesion was seen in the tail of the pancreas. MRI showed a focal pancreatic duct cut-off with mild ductal dilation. Fine needle aspiration was performed, which was concerning for acinar cell carcinoma. The patient underwent distal pancreatectomy and recovered uneventfully. Final pathology demonstrated a 1.3-cm hepatoid carcinoma of the pancreas, with a final clinicopathological stage of T1N0M0. Next-generation nucleic acid sequencing of the tumor did not suggest a viable adjuvant chemotherapeutic agent, and no adjuvant therapy was administered. The patient has no evidence of disease 6 months following resection. A further characterization and description of the outcomes of these rare tumors is warranted to help guide providers and counsel patients.
authors.affiliation: Division of Transplant and Hepatopancreatobiliary Surgery, Mayo Clinic Arizona, Phoenix, Ariz., USA.
authors.forename: James M
authors.initials: JM
authors.lastname: Chang
authors.affiliation: Division of Transplant and Hepatopancreatobiliary Surgery, Mayo Clinic Arizona, Phoenix, Ariz., USA.
authors.forename: Nitin N
authors.initials: NN
authors.lastname: Katariya
authors.affiliation: Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, Phoenix, Ariz., USA.
authors.forename: Dora M
authors.initials: DM
authors.lastname: Lam-Himlin
authors.affiliation: Division of Transplant and Hepatopancreatobiliary Surgery, Mayo Clinic Arizona, Phoenix, Ariz., USA.
authors.forename: Danielle J
authors.initials: DJ
authors.lastname: Haakinson
authors.affiliation: Division of Hematology/Oncology, Mayo Clinic Arizona, Phoenix, Ariz., USA.
authors.forename: Ramesh K
authors.initials: RK
authors.lastname: Ramanathan
authors.affiliation: Division of Hematology/Oncology, Mayo Clinic Arizona, Phoenix, Ariz., USA.
authors.forename: Thorvardur R
authors.initials: TR
authors.lastname: Halfdanarson
authors.affiliation: Division of Hematology/Oncology, Mayo Clinic Arizona, Phoenix, Ariz., USA.
authors.forename: Mitesh J
authors.initials: MJ
authors.lastname: Borad
authors.affiliation: Division of Gastroenterology/Hepatology, Mayo Clinic Arizona, Phoenix, Ariz., USA.
authors.forename: Rahul
authors.initials: R
authors.lastname: Pannala
authors.affiliation: Division of Gastroenterology/Hepatology, Mayo Clinic Arizona, Phoenix, Ariz., USA.
authors.forename: Douglas
authors.initials: D
authors.lastname: Faigel
authors.affiliation: Division of Transplant and Hepatopancreatobiliary Surgery, Mayo Clinic Arizona, Phoenix, Ariz., USA.
authors.forename: Adyr A
authors.initials: AA
authors.lastname: Moss
authors.affiliation: Division of Transplant and Hepatopancreatobiliary Surgery, Mayo Clinic Arizona, Phoenix, Ariz., USA.
authors.forename: Amit K
authors.initials: AK
authors.lastname: Mathur
keywords: Hepatoid carcinoma; Pancreatic cancer