title: Focal Adhesion Kinase: A promising therapeutic target in pancreatic adenocarcinoma.
abstract: Pancreatic ductal adenocarcinoma (PDAC) remains a deadly cancer, characterized by a uniquely immunosuppressive and fibrotic microenvironment responsible for its high chemoresistance. Jiang et al. identify FAK (focal adhesion kinase) activity as an interesting therapeutic target, the inhibition of which drastically reduces PDAC microenvironment deleterious features. In combination with gemcitabine and immune-checkpoint therapy, FAK inhibitor promotes long-term tumor stasis with extended survival in PDAC mouse models. In conclusion, Jiang et al. provide proof of concept that FAK inhibitors combined with chemotherapy will highly profit PDAC patients.
authors.affiliation: UMR 1037 INSERM-UPS ERL CNRS 5294, Cancer Research Center of Toulouse, Tumor Biology Department, Team 6, 31037 Toulouse, France.
authors.forename: Emilie
authors.initials: E
authors.lastname: Decaup
authors.affiliation: UMR 1037 INSERM-UPS ERL CNRS 5294, Cancer Research Center of Toulouse, Tumor Biology Department, Team 6, 31037 Toulouse, France.
authors.forename: Julia
authors.initials: J
authors.lastname: Rochotte
authors.affiliation: UMR 1037 INSERM-UPS ERL CNRS 5294, Cancer Research Center of Toulouse, Tumor Biology Department, Team 6, 31037 Toulouse, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Pyronnet
authors.affiliation: UMR 1037 INSERM-UPS ERL CNRS 5294, Cancer Research Center of Toulouse, Tumor Biology Department, Team 6, 31037 Toulouse, France.
authors.forename: Corinne
authors.initials: C
authors.lastname: Bousquet
authors.affiliation: UMR 1037 INSERM-UPS ERL CNRS 5294, Cancer Research Center of Toulouse, Tumor Biology Department, Team 6, 31037 Toulouse, France. Electronic address: christine.jean@inserm.fr.
authors.forename: Christine
authors.initials: C
authors.lastname: Jean
mesh_terms: D000230:Adenocarcinoma; D000818:Animals; D021441:Carcinoma, Pancreatic Ductal; D051416:Focal Adhesion Protein-Tyrosine Kinases; D006801:Humans; D051379:Mice; D010190:Pancreatic Neoplasms; D059016:Tumor Microenvironment
chemical_list: D051416:Focal Adhesion Protein-Tyrosine Kinases