title: The association between serum uric acid and glaucoma severity in primary angle closure glaucoma: a retrospective case-control study.
abstract: Uric acid (UA) is a major antioxidant molecule and has been hypothesized to have a protective effect on the central nervous system against oxidative damage. We prospectively investigated the serum concentration of UA in primary angle closure glaucoma (PACG), and explored the association between serum concentration of UA and the severity of PACG. Using a retrospective case-control study design, 886 PACG subjects and 994 control subjects who attended the Eye & ENT Hospital of Fudan University, were eligible for this study. Glaucoma severity was classified as mild (MD ≤ 6.00 dB), moderate (12 dB ≥ MD > 6 dB) and severe (MD > 12 dB) based on the MD (mean deviation). The levels of UA were significantly lower (p = 0.025) in PACG (0.286 ± 0.082 mmol/l) compared with control (0.295 ± 0.085 mmol/l). The mean serum UA levels were lowest in the severe group (0.281 ± 0.074 mmol/l) followed by moderate (0.282 ± 0.080 mmol/l) and mild (0.297 ± 0.090 mmol/l) with significant differences among the three groups (p = 0.032). In multivariate regression analysis, there was a significant negative correlation between UA level and vertical cup-disc ratio (B = -0.165, p = 0.035). Significantly lower serum UA concentration in PACG and its negative association with disease severity presented it as an important candidate in reaction to oxidative stress in glaucoma pathogenesis.
authors.affiliation: Department of Clinical Laboratory, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shangai, China.
authors.forename: Shengjie
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Clinical Laboratory, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shangai, China.
authors.forename: Mingxi
authors.initials: M
authors.lastname: Shao
authors.affiliation: Department of Clinical Laboratory, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shangai, China.
authors.forename: Binghua
authors.initials: B
authors.lastname: Tang
authors.affiliation: Department of Clinical Laboratory, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shangai, China.
authors.forename: Aiping
authors.initials: A
authors.lastname: Zhang
authors.affiliation: Department of Clinical Laboratory, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shangai, China.|Department of Ophthalmology and Visual Science, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shangai, China.
authors.forename: Wenjun
authors.initials: W
authors.lastname: Cao
authors.affiliation: Department of Ophthalmology and Visual Science, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shangai, China.|State Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, China.|Key Laboratory of Myopia, Ministry of Health (Fudan University), Shangai, China.|Shanghai Key Laboratory of Visual Impairment and Restoration (Fudan University), Shangai, China.
authors.forename: Xinghuai
authors.initials: X
authors.lastname: Sun
mesh_terms: D000368:Aged; D015415:Biomarkers; D016022:Case-Control Studies; D003404:Creatinine / Q000097:blood; D005260:Female; D015812:Glaucoma, Angle-Closure / Q000097:blood* / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D012189:Retrospective Studies; D012720:Severity of Illness Index; D014527:Uric Acid / Q000097:blood*
chemical_list: D015415:Biomarkers; D014527:Uric Acid; D003404:Creatinine
keywords: oxidative stress; primary angle closure glaucoma; serum; uric acid