title: The Dynamics of T and B Cells in Lymph Node during Chronic HIV Infection: TFH and HIV, Unhappy Dance Partners?
abstract: Although the dynamics of germinal center (GC) formation, follicular helper T (TFH) cell recruitment toB cell follicles within lymphoid organs, and changes of lymphoid tissue architecture in HIV/SIV infection have been documented, the underlying immunopathology remains unclear. Here, we summarize what is known regarding the kinetics of TFH cells andGC B cellsduring the course of infection as well as the potential immunopathological features associated with structural changes in the lymphoid compartment. This review also explores the implications of cell dynamics in the formation and maintenance of viral reservoirs in hyperplastic follicles of secondary lymphoid organs before and after viral suppressive antiretroviral therapy.
authors.affiliation: National Primate Research Center (NPRC), Korea Research Institute of Bioscience and Biotechnology (KRIBB) , Cheongju , South Korea.
authors.forename: Jung Joo
authors.initials: JJ
authors.lastname: Hong
authors.affiliation: National Primate Research Center (NPRC), Korea Research Institute of Bioscience and Biotechnology (KRIBB) , Cheongju , South Korea.
authors.forename: Kyu-Tae
authors.initials: KT
authors.lastname: Chang
authors.affiliation: New Iberia Research Center, University of Louisiana Lafayette , Lafayette, LA , USA.
authors.forename: Francois
authors.initials: F
authors.lastname: Villinger
keywords: HIV; SIV; TFH cells; germinal center; hyperplastic follicle