title: [Effect of family integrate care on the development of preterm infants at 18 months of age].
abstract: Objective:To study the effect of family integrated care (FIC) in neonatal intensive care unit (NICU) to the development of preterm infants at 18 months of age.Method:This is a prospective parallel case-control study. Infants in FIC group were preterm infants enrolled in previous FIC study with gestational age (GA) 28-35 weeks. Study period was from July 2015 to July 2016. Subjects were all enrolled from Department of Child Healthcare in the Third Xiangya Hospital of Central South University. Infants in control group were gender, birth weight (BW), BW percentile and days of life (DOL) at follow-up matched (1∶1 ratio) preterm infants who did not enter FIC in NICU. The age at follow-up was 18 months. Study parameters were maternal education year, socioeconomic status (SES) by Graffar method, home observation for measurement of the environment (HOME), mental development index (MDI) and psychomotor development index (PDI) by mental and psychomotor Bayley scales of infant development (BSID). SPSS 20.0 of χ2test,ttest, Pearson coefficient test and Spearman coefficient test were used for the statistical analysis.Result:Totally 67 infants were enrolled in each of FIC group and control group, with percentage of male gender 52% (35 infants) and 51% (34 infants), representatively. GA of FIC group and control group was (32.4±1.7) and (32.2±1.6) weeks, BW was (1 690±415) and (1 719±412) g. Weight at 18 months follow-up was (10±1) and (10±1) kg, maternal education year was (15±2) and (15±2) years, SES was (42±6) and (41±6) score, HOME was (31±5) and (32±5) score, representatively. There was no significant difference between FIC group and control group in the above parameters, making these 2 groups comparable. The MDI and PDI of FIC group were significantly higher than those of control group ((95±9)vs. (86±9), (87±9)vs. (80±8) score,t=5.506, 4.502, bothP=0.000). The MDI and PDI of all groups were positively correlated to GA (r=0.398 and 0.272,P=0.000 and 0.001), but the difference of MDI or PDI between FIC group and control group was not related to GA (r=0.679 and -0.393,P=0.094 and 0.383).Conclusion:FIC in NICU is beneficial to the development of preterm infants at 18 months of age. It is worthwhile to promote FIC in NICU in China.Trial registration:Chinese Clinical Trial Registry, ChiCTR-TRC-14004736.
authors.affiliation: Department of Pediatrics, Central South University, Changsha 410013, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.forename: X Y
authors.initials: XY
authors.lastname: Gao
authors.forename: X Y
authors.initials: XY
authors.lastname: Xiang
authors.forename: H M
authors.initials: HM
authors.lastname: Dai
authors.forename: L
authors.initials: L
authors.lastname: Yang
authors.forename: M Y
authors.initials: MY
authors.lastname: Shoo K
authors.forename: Mingyan
authors.initials: M
authors.lastname: Hei
mesh_terms: D001724:Birth Weight; D016022:Case-Control Studies; D002657:Child Development; D002681:China; D022143:Family Nursing / Q000379:methods / Q000458:organization & administration*; D005260:Female; D006801:Humans; D007223:Infant; D007224:Infant Care / Q000379:methods / Q000458:organization & administration*; D007231:Infant, Newborn; D007234:Infant, Premature / Q000254:growth & development*; D007235:Infant, Premature, Diseases; D019102:Infant, Very Low Birth Weight; D007363:Intensive Care Units, Neonatal / Q000458:organization & administration*; D008297:Male; D009035:Mothers / Q000193:education* / Q000523:psychology; D011446:Prospective Studies; D012307:Risk Factors