title: Effect of intensive lipid-lowering therapies on cholinesterase activity in patients with coronary artery disease.
abstract: BACKGROUND
  Many disease entities, including coronary artery disease (CAD), demonstrate abnormalities in the activity of cholinesterases. As CAD is characterized by an increase in cholesterol level, patients with this disease are treated with lipid-lowering drugs. The present study attempts to determine how statin or combined statin and ezetimibe therapy influences cholinesterase activity.
  
  
  METHODS
  Plasma and erythrocytes were isolated from the peripheral blood of CAD patients (n=61) and healthy subjects (n=63). The patients were randomized into three groups: 20mg/day rosuvastatin, 40mg/day atorvastatin, and combined 10mg/day atorvastatin with 10mg/day ezetimibe. The following parameters were studied: activity of acetylcholinesterase (AChE) and butyrylcholinoesterase (BChE) and lipid levels.
  
  
  RESULTS
  Patients with CAD demonstrated significant increase in AChE and BChE activity. We observed increase in the level of low-density lipoprotein cholesterol (LDL) and triglycerides (TG) level, and decrease in high density lipoprotein cholesterol (HDL) level. After atorvastatin monotherapy, the following decrease in activity were observed: 17% LDL, 43% total cholesterol (TC) level, 33% AChE and 17% BChE. The following decrease in activity were observed following rosuvastatin monotherapy: 26% LDL level, 26% AChE and 18% BChE. After combined atorvastatin+ezetimibe therapy, the following decrease in activity occurred: 27% of LDL level, 15% TC, 33% of AChE and 20% BChE.
  
  
  CONCLUSIONS
  Our results suggest that intensive lipid-lowering therapy has a beneficial effect on AChE and BChE activity and lipid levels. Combination atorvastatin+ezetimibe therapy was found to have similar effects on the tested parameters as statin monotherapy.
authors.affiliation: Department of Environmental Pollution Biophysics, Faculty of Biology and Environmental Protection, University of Łódź, ul. Pomorska 141/143, 90-236 Łódź, Poland. Electronic address: epytel@biol.uni.lodz.pl.
authors.forename: Edyta
authors.initials: E
authors.lastname: Pytel
authors.affiliation: Department of Environmental Pollution Biophysics, Faculty of Biology and Environmental Protection, University of Łódź, ul. Pomorska 141/143, 90-236 Łódź, Poland.
authors.forename: Bożena
authors.initials: B
authors.lastname: Bukowska
authors.affiliation: Department of Environmental Pollution Biophysics, Faculty of Biology and Environmental Protection, University of Łódź, ul. Pomorska 141/143, 90-236 Łódź, Poland.
authors.forename: Maria
authors.initials: M
authors.lastname: Koter-Michalak
authors.affiliation: Department of Internal Diseases and Clinical Pharmacology, Medical University of Łódź, ul. Kniaziewicza 1/5, 91-347 Łódź, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Olszewska-Banaszczyk
authors.affiliation: Department of Internal Diseases and Clinical Pharmacology, Medical University of Łódź, ul. Kniaziewicza 1/5, 91-347 Łódź, Poland.
authors.forename: Paulina
authors.initials: P
authors.lastname: Gorzelak-Pabiś
authors.affiliation: Department of Internal Diseases and Clinical Pharmacology, Medical University of Łódź, ul. Kniaziewicza 1/5, 91-347 Łódź, Poland.
authors.forename: Marlena
authors.initials: M
authors.lastname: Broncel
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism*; D000368:Aged; D000924:Anticholesteremic Agents / Q000008:administration & dosage*; D002091:Butyrylcholinesterase / Q000378:metabolism*; D008076:Cholesterol, HDL / Q000037:antagonists & inhibitors / Q000097:blood; D008078:Cholesterol, LDL / Q000037:antagonists & inhibitors / Q000097:blood; D003324:Coronary Artery Disease / Q000188:drug therapy* / Q000201:enzymology*; D004359:Drug Therapy, Combination; D004789:Enzyme Activation / Q000187:drug effects / Q000502:physiology; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D000924:Anticholesteremic Agents; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase
keywords: Acetylocholinesterase activity; Butyrylocholinesterase activity; Coronary artery disease