title: New targeted therapies for malignant lymphoma based on molecular heterogeneity.
abstract: Owing to tremendous advances in the understanding of mechanisms involved in the pathogenesis of malignant tumors an emerging field of novel targeted drugs has evolved within the last decade. This is of particular interest also for malignant lymphomas, constituting a heterogeneous tumor category with substantial variation in clinical outcome, ranging from indolent forms that do not require treatment over years to aggressive cases for which an immediate treatment is mandatory. The elucidation of different molecular strategies adopted by malignant cells has led to a profound profiling of tumor-specific features and consequently resulted in the development of new targeted therapies. Areas covered: A review of currently tested tailored approaches, in particular in B-cell lymphomas (B-NHL), ranging from monoclonal antibodies to inhibition of intrinsic and extrinsic effector molecules. These approaches are currently tested in several subtypes of B-NHL both in preclinical studies and in clinical trials and are summarized within this review. Expert commentary: Considering how quickly basic scientific discoveries could meanwhile be transferred to clinical trials and approvals, future perspectives for novel tailored therapeutic strategies are promising.
authors.affiliation: a Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart and University of Tübingen , Stuttgart , Germany.
authors.forename: Heike
authors.initials: H
authors.lastname: Horn
authors.affiliation: a Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart and University of Tübingen , Stuttgart , Germany.|b Department of Clinical Pathology , Robert-Bosch-Krankenhaus Stuttgart , Stuttgart , Germany.
authors.forename: Annette M
authors.initials: AM
authors.lastname: Staiger
authors.affiliation: b Department of Clinical Pathology , Robert-Bosch-Krankenhaus Stuttgart , Stuttgart , Germany.
authors.forename: German
authors.initials: G
authors.lastname: Ott
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D018450:Disease Progression; D004353:Drug Evaluation, Preclinical; D018740:Genetic Heterogeneity; D014644:Genetic Variation; D006801:Humans; D007167:Immunotherapy / Q000009:adverse effects / Q000379:methods; D008223:Lymphoma / Q000188:drug therapy* / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D058990:Molecular Targeted Therapy; D015398:Signal Transduction / Q000187:drug effects; D059016:Tumor Microenvironment
chemical_list: D000970:Antineoplastic Agents
keywords: ABC-like DLBCL; B-cell Non-Hodgkin lymphoma (B-NHL); GCB-like DLBCL; diffuse large B-cell lymphoma (DLBCL); immune modulatory drugs; monoclonal antibodies; proteasome inhibitors; small molecule inhibitors; tyrosine kinase inhibitors