title: Co-delivery of all-trans-retinoic acid enhances the anti-metastasis effect of albumin-bound paclitaxel nanoparticles.
abstract: Co-delivery of all-trans-retinoic acid and paclitaxel using albumin-bound nanoparticles demonstrated a significantly improved anti-metastatic effect to breast cancer both in vitro and in vivo. Notably, the co-delivery nanoparticles exhibited more pronounced therapeutic effects than the combination of two free drugs or two HSA loaded single drugs.
authors.affiliation: CAS Key Laboratory of Soft Matter Chemistry, CAS High Magnetic Field Laboratory, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China. liuyz@ustc.edu.cn.
authors.forename: Hai
authors.initials: H
authors.lastname: Huang
authors.affiliation: CAS Key Laboratory of Soft Matter Chemistry, CAS High Magnetic Field Laboratory, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China. liuyz@ustc.edu.cn.
authors.forename: Hongdong
authors.initials: H
authors.lastname: Shi
authors.affiliation: School of Life Sciences, University of Science and Technology of China, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
authors.forename: Yuanzeng
authors.initials: Y
authors.lastname: Min
authors.affiliation: School of Life Sciences, University of Science and Technology of China, China.
authors.forename: Yucai
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
authors.forename: Andrew Z
authors.initials: AZ
authors.lastname: Wang
authors.affiliation: School of Life Sciences, University of Science and Technology of China, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.affiliation: CAS Key Laboratory of Soft Matter Chemistry, CAS High Magnetic Field Laboratory, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China. liuyz@ustc.edu.cn.
authors.forename: Yangzhong
authors.identifier: 0000-0003-2891-7964
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000068196:Albumin-Bound Paclitaxel / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000473:pathology; D045744:Cell Line, Tumor; D004337:Drug Carriers / Q000737:chemistry*; D006801:Humans; D051379:Mice; D008958:Models, Molecular; D053758:Nanoparticles / Q000737:chemistry*; D009362:Neoplasm Metastasis; D011487:Protein Conformation; D014212:Tretinoin / Q000737:chemistry*
chemical_list: D000068196:Albumin-Bound Paclitaxel; D000970:Antineoplastic Agents; D004337:Drug Carriers; D014212:Tretinoin