title: Autophagy as a regulator of cardiovascular redox homeostasis.
abstract: Autophagy is a highly regulated process involving the removal of damaged proteins and organelles from cells and tissues through a lysosomal-mediated pathway. Accumulating evidence suggests that autophagy is necessary to maintain redox homeostasis. Here, we explore the connection between autophagy and reactive oxygen species (ROS). In particular, we discuss how oxidant-dependent signaling can modulate autophagic flux and how autophagy can, in turn, modulate ROS levels. Finally, we discuss how a decline or disruption of autophagy might contribute to redox-dependent cardiovascular pathology and help fuel the age-dependent decline in cardiovascular function.
authors.affiliation: Center for Molecular Medicine, National Heart Lung and Blood Institute, NIH, Bethesda, MD 20892, USA.
authors.forename: Ye
authors.initials: Y
authors.lastname: Yan
authors.affiliation: Center for Molecular Medicine, National Heart Lung and Blood Institute, NIH, Bethesda, MD 20892, USA. Electronic address: finkelt@nih.gov.
authors.forename: Toren
authors.initials: T
authors.lastname: Finkel
mesh_terms: D000818:Animals; D001343:Autophagy / Q000235:genetics*; D000071183:Autophagy-Related Proteins / Q000235:genetics / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D002319:Cardiovascular System / Q000378:metabolism / Q000473:pathology; D003546:Cysteine Endopeptidases / Q000235:genetics / Q000378:metabolism; D042783:Endothelial Cells / Q000378:metabolism* / Q000473:pathology; D005786:Gene Expression Regulation; D006706:Homeostasis / Q000235:genetics; D006801:Humans; D008247:Lysosomes / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism* / Q000473:pathology; D063306:Mitophagy / Q000235:genetics; D010084:Oxidation-Reduction; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015398:Signal Transduction; D050051:Transient Receptor Potential Channels / Q000235:genetics / Q000378:metabolism
chemical_list: D000071183:Autophagy-Related Proteins; C416674:MCOLN1 protein, human; D017382:Reactive Oxygen Species; D050051:Transient Receptor Potential Channels; C474025:ATG4A protein, human; D003546:Cysteine Endopeptidases
keywords: Autophagy; Cardiovascular disease; Mitophagy; ROS