title: Vasopressors and Inotropes in Sepsis.
abstract: Vasopressor and inotropes are beneficial in shock states. Norepinephrine is considered the first-line vasopressor for patients with sepsis-associated hypotension. Dobutamine is considered the first-line inotrope in sepsis, and should be considered for patients with evidence of myocardial dysfunction or ongoing signs of hypoperfusion. Vasopressor and inotrope therapy has complex effects that are often difficult to predict; emergency providers should consider the physiology and clinical trial data. It is essential to continually reevaluate the patient to determine if the selected treatment is having the intended result.
authors.affiliation: Division of Emergency Medicine, New York Presbyterian Hospital/Weill Cornell Medical Center, New York, NY, USA.
authors.forename: Leeanne
authors.initials: L
authors.lastname: Stratton
authors.affiliation: Division of Pulmonary and Critical Care Medicine, New York Presbyterian Hospital/Weill Cornell Medical Center, New York, NY, USA.
authors.forename: David A
authors.initials: DA
authors.lastname: Berlin
authors.affiliation: Division of Emergency Medicine, New York Presbyterian Hospital/Weill Cornell Medical Center, New York, NY, USA; Division of Pulmonary and Critical Care Medicine, New York Presbyterian Hospital/Weill Cornell Medical Center, New York, NY, USA. Electronic address: jea9030@med.cornell.edu.
authors.forename: John E
authors.initials: JE
authors.lastname: Arbo
mesh_terms: D002316:Cardiotonic Agents / Q000627:therapeutic use*; D004280:Dobutamine / Q000627:therapeutic use; D004636:Emergency Service, Hospital; D006321:Heart / Q000187:drug effects; D006801:Humans; D009638:Norepinephrine / Q000627:therapeutic use; D018805:Sepsis / Q000188:drug therapy*; D012772:Shock, Septic / Q000188:drug therapy; D014662:Vasoconstrictor Agents / Q000627:therapeutic use*
chemical_list: D002316:Cardiotonic Agents; D014662:Vasoconstrictor Agents; D004280:Dobutamine; D009638:Norepinephrine
keywords: Cardiac contractility; Dopamine; Epinephrine; Inotropes; Norepinephrine; Sepsis; Septic shock; Vasopressors