title: Tumor Microenvironment Metabolism: A New Checkpoint for Anti-Tumor Immunity.
abstract: When a T cell infiltrates a tumor, it is subjected to a variety of immunosuppressive and regulatory signals in the microenvironment. However, it is becoming increasingly clear that due to the proliferative and energetically-deregulated nature of tumor cells, T cells also operate at a metabolic disadvantage. The nutrient dearth of the tumor microenvironment (TME) creates "metabolic checkpoints" upon infiltrating T cells, impacting their ability to survive, proliferate and function effectively. In this review, we summarize the basics of tumor cell and T cell metabolism and discuss recent advances elucidating the individual metabolic checkpoints exerted on T cells that drive their dysfunction in the TME.
authors.affiliation: Tumor Microenvironment Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA. nes63@pitt.edu.|Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15213, USA. nes63@pitt.edu.
authors.forename: Nicole E
authors.initials: NE
authors.lastname: Scharping
authors.affiliation: Tumor Microenvironment Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA. delgoffeg@upmc.edu.|Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15213, USA. delgoffeg@upmc.edu.
authors.forename: Greg M
authors.initials: GM
authors.lastname: Delgoffe
keywords: T cell; cancer; immunotherapy; metabolic checkpoints; metabolism; tumor microenvironment