title: One-Anastomosis Gastric Bypass: Why Biliary Reflux Remains Controversial?
abstract: One-anastomosis gastric bypass is an alternative to the "gold-standard" Roux-en-Y gastric bypass. This technique appears to be safe and efficient, but controversy remains regarding the long-term theoretical risk of subsequent biliary reflux and its possible complications, such as cancer. The aim of the present narrative review was to summarize some of the current thoughts on biliary reflux. Research has established that exposure to chronic bile reflux in humans and rats (outside the "bariatric surgery" box) induce esophageal intestinal metaplasia and esophageal adenocarcinoma. Although one-anastomosis gastric bypass can theoretically induce chronic biliary reflux, the incidence of biliary reflux and risk of cancer have not been prospectively evaluated. Clarification of this controversial issue is urgently needed.
authors.affiliation: Service de chirurgie digestive, Hôpital Européen Georges Pompidou, 20 rue Leblanc, 75015, Paris cedex, France. matthieu.bruzzi@aphp.fr.|Université Paris Descartes, Paris, France. matthieu.bruzzi@aphp.fr.
authors.forename: Matthieu
authors.initials: M
authors.lastname: Bruzzi
authors.affiliation: Service de chirurgie digestive, Hôpital Européen Georges Pompidou, 20 rue Leblanc, 75015, Paris cedex, France.|Université Paris Descartes, Paris, France.
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Chevallier
authors.affiliation: Université Paris Descartes, Paris, France.|Service de Nutrition, Hôpital Européen Georges Pompidou, Paris, France.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Czernichow
mesh_terms: D000818:Animals; D001655:Bile Reflux / Q000209:etiology*; D015390:Gastric Bypass / Q000009:adverse effects / Q000379:methods; D006801:Humans; D051381:Rats
keywords: Biliary reflux; Cancer; Mini-gastric bypass; One-anastomosis gastric bypass