title: Effect of Perioperative Pregabalin on Postoperative Quality of Recovery in Patients Undergoing Off-Pump Coronary Artery Bypass Grafting (OPCABG): A Prospective, Randomized, Double-Blind Trial.
abstract: OBJECTIVE
  Use of pregabalin is increasing in cardiac surgical patients. However, studies using comprehensive scoring systems are lacking on the drug's impact on postoperative recovery. The authors tested the hypothesis that perioperative oral pregabalin improves the postoperative quality of recovery as assessed using the Quality of Recovery (QoR-40) questionnaire in patients undergoing off-pump coronary artery bypass grafting (OPCABG).
  
  
  METHODS
  This was a randomized, double-blind, placebo-controlled study.
  
  
  METHODS
  Tertiary-care hospital.
  
  
  METHODS
  Patients undergoing OPCABG.
  
  
  METHODS
  Patients were assigned randomly to the following 2 groups: the pregabalin group (those who received pregabalin, 150 mg capsule orally, 1 hour before surgery and 2 days postoperatively [75 mg twice a day] starting after extubation; n = 37); and the control group (those who received 2 similar-looking multivitamin capsules at similar times; n = 34). The QoR-40 scores were noted preoperatively and 24 hours after extubation.
  
  
  RESULTS
  Both groups were comparable in terms of preoperative patient characteristics and baseline QoR-40 scores. Global scores were significantly improved in the pregabalin group compared with the control group in the postoperative period (177±9 v 170±9; p = 0.002). QoR-40 values in the dimensions of emotional state (p = 0.005), physical comfort (p = 0.04), and pain (p = 0.02) were improved in the pregabalin group.
  
  
  CONCLUSIONS
  Perioperative pregabalin improved postoperative quality of recovery as assessed using the QoR-40 questionnaire in patients undergoing OPCABG. Perioperative pregabalin offered advantages beyond better pain control, such as improved physical comfort and better emotional state; therefore, the drug's use in the perioperative period is recommended.
authors.affiliation: Ozone Anesthesia Group, Aurangabad, Maharashtra, India. Electronic address: deepakborde2482@gmail.com.
authors.forename: Deepak Prakash
authors.initials: DP
authors.lastname: Borde
authors.affiliation: Ozone Anesthesia Group, Aurangabad, Maharashtra, India.
authors.forename: Savani Sameer
authors.initials: SS
authors.lastname: Futane
authors.affiliation: Ozone Anesthesia Group, Aurangabad, Maharashtra, India.
authors.forename: Balaji
authors.initials: B
authors.lastname: Asegaonkar
authors.affiliation: Ozone Anesthesia Group, Aurangabad, Maharashtra, India.
authors.forename: Pramod
authors.initials: P
authors.lastname: Apsingekar
authors.affiliation: Ozone Anesthesia Group, Aurangabad, Maharashtra, India.
authors.forename: Sujeet
authors.initials: S
authors.lastname: Khade
authors.affiliation: Ozone Anesthesia Group, Aurangabad, Maharashtra, India.
authors.forename: Bapu
authors.initials: B
authors.lastname: Khodve
authors.affiliation: Seth Nandlal Dhoot Hospital, Aurangabad, Maharashtra, India.
authors.forename: Manish
authors.initials: M
authors.lastname: Puranik
authors.affiliation: Fortis Hospitals, Bengaluru, Karnataka, India.
authors.forename: Antony
authors.initials: A
authors.lastname: George
authors.affiliation: Nayati Super-Speciality Hospital, Mathura, Uttar Pradesh, India.
authors.forename: Shreedhar
authors.initials: S
authors.lastname: Joshi
mesh_terms: D000368:Aged; D000700:Analgesics / Q000008:administration & dosage*; D001026:Coronary Artery Bypass / Q000009:adverse effects* / Q000639:trends; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement / Q000379:methods; D010149:Postoperative Pain / Q000175:diagnosis / Q000517:prevention & control; D019990:Perioperative Care / Q000379:methods*; D011182:Postoperative Care / Q000379:methods*; D000069583:Pregabalin / Q000008:administration & dosage*; D011446:Prospective Studies; D020127:Recovery of Function / Q000187:drug effects* / Q000502:physiology; D016896:Treatment Outcome
chemical_list: D000700:Analgesics; D000069583:Pregabalin
keywords: Quality of Recovery-40; off-pump coronary artery bypass grafting; pregabalin