title: Fluctuating Vestibulo-Ocular Reflex in Ménière's Disease.
abstract: To describe the fluctuating high velocity vestibular ocular-reflex (VOR) during the Ménière's attacks and correlate those features with pathophysiology.
  
  
  
  A patient with unilateral Ménière's disease (MD) was evaluated closely during and after acute vertigo episodes.
  
  
  
  The spontaneous nystagmus and the dynamic VOR changes were measured by the video head impulse test (VHIT) at different stages of the vertigo crisis and during the quiescent phase of the condition.
  
  
  
  During the Ménière's attack, the VOR gain showed large changes on the affected side; however, on recovery a return to the normal value was evident. The VOR gain also showed fluctuation on follow up, paralleling symptoms. The greatest reduction of the VOR was during the paralytic nystagmus phase.
  
  
  
  The present case documents rapid vestibular fluctuation documented with VHIT testing in MD. The ionic-chemical perilymphatic intoxication and the endolymphatic space collapse due to membrane rupture could explain those features. VHIT fluctuation is a promising tool for diagnosis of patients with episodic vestibular symptoms.
authors.affiliation: *Neurology Department, "Cesar Milstein" Hospital †Memory and Balance Clinic, Buenos Aires, Argentina ‡Department of Physical Therapy and Human Movement Science, Northwestern University, Chicago, Illinois, U.S.A.
authors.forename: Dario A
authors.initials: DA
authors.lastname: Yacovino
authors.forename: Timothy C
authors.initials: TC
authors.lastname: Hain
authors.forename: Maria
authors.initials: M
authors.lastname: Musazzi
mesh_terms: D064087:Head Impulse Test; D006801:Humans; D008297:Male; D008575:Meniere Disease / Q000150:complications / Q000503:physiopathology*; D008875:Middle Aged; D009759:Nystagmus, Pathologic / Q000503:physiopathology; D012027:Reflex, Vestibulo-Ocular / Q000502:physiology*; D014717:Vertigo / Q000209:etiology / Q000503:physiopathology; D014722:Vestibule, Labyrinth / Q000503:physiopathology