title: Functional dedifferentiation and reduced task-related deactivations underlie the age-related decline of prospective memory.
abstract: Prospective memory (PM) refers to the ability to remember to execute an intention at the appropriate moment in the future, which can be performed either at the appearance of an event (event-based, EBPM) or after a certain amount of time (time-based, TBPM). PM is generally impaired during aging but the cerebral substrates of this decline have been little investigated. Using functional Magnetic Resonance Imaging (fMRI), we investigated the neural bases of PM in 20 young and 20 healthy older adults. They were proposed a task of semantic categorisation of pictures (ongoing task). For some blocks, participants only had to perform this ongoing task while, for others, a PM instruction was added. In this case, a supplementary answer in response to a specific colour of border for EBPM or at specific time intervals for TBPM was expected. PM, and more particularly TBPM, declined in older adults. For both PM conditions, older adults recruited additional brain areas, but also showed reduced deactivations of other regions. These results are discussed in light of models of the aging brain.
authors.affiliation: Normandie Univ, UNICAEN, PSL Research University, EPHE, INSERM, U1077, CHU de Caen, Neuropsychologie et Imagerie de la Mémoire Humaine, 14000, Caen, France.
authors.forename: Julie
authors.initials: J
authors.lastname: Gonneaud
authors.affiliation: Normandie Univ, UNICAEN, PSL Research University, EPHE, INSERM, U1077, CHU de Caen, Neuropsychologie et Imagerie de la Mémoire Humaine, 14000, Caen, France.
authors.forename: Grégory
authors.initials: G
authors.lastname: Lecouvey
authors.affiliation: Normandie Univ, UNICAEN, PSL Research University, EPHE, INSERM, U1077, CHU de Caen, Neuropsychologie et Imagerie de la Mémoire Humaine, 14000, Caen, France.
authors.forename: Mathilde
authors.initials: M
authors.lastname: Groussard
authors.affiliation: Normandie Univ, UNICAEN, PSL Research University, EPHE, INSERM, U1077, CHU de Caen, Neuropsychologie et Imagerie de la Mémoire Humaine, 14000, Caen, France.
authors.forename: Malo
authors.initials: M
authors.lastname: Gaubert
authors.affiliation: Normandie Univ, UNICAEN, PSL Research University, EPHE, INSERM, U1077, CHU de Caen, Neuropsychologie et Imagerie de la Mémoire Humaine, 14000, Caen, France.
authors.forename: Brigitte
authors.initials: B
authors.lastname: Landeau
authors.affiliation: Normandie Univ, UNICAEN, PSL Research University, EPHE, INSERM, U1077, CHU de Caen, Neuropsychologie et Imagerie de la Mémoire Humaine, 14000, Caen, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Mézenge
authors.affiliation: Normandie Univ, UNICAEN, PSL Research University, EPHE, INSERM, U1077, CHU de Caen, Neuropsychologie et Imagerie de la Mémoire Humaine, 14000, Caen, France.|CHU de Caen, Service de Neurologie, 14000, Caen, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: de La Sayette
authors.affiliation: Normandie Univ, UNICAEN, PSL Research University, EPHE, INSERM, U1077, CHU de Caen, Neuropsychologie et Imagerie de la Mémoire Humaine, 14000, Caen, France.
authors.forename: Francis
authors.initials: F
authors.lastname: Eustache
authors.affiliation: Normandie Univ, UNICAEN, PSL Research University, EPHE, INSERM, U1077, CHU de Caen, Neuropsychologie et Imagerie de la Mémoire Humaine, 14000, Caen, France.
authors.forename: Béatrice
authors.initials: B
authors.lastname: Desgranges
authors.affiliation: Normandie Univ, UNICAEN, PSL Research University, EPHE, INSERM, U1077, CHU de Caen, Neuropsychologie et Imagerie de la Mémoire Humaine, 14000, Caen, France. rauchs@cyceron.fr.
authors.forename: Géraldine
authors.initials: G
authors.lastname: Rauchs
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology* / Q000523:psychology*; D001921:Brain / Q000000981:diagnostic imaging / Q000502:physiology*; D001931:Brain Mapping; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D061212:Memory, Episodic; D008875:Middle Aged; D008959:Models, Neurological; D009483:Neuropsychological Tests; D011930:Reaction Time; D012660:Semantics; D014796:Visual Perception / Q000502:physiology; D055815:Young Adult
keywords: Event-based; Functional MRI; Healthy aging; Prospective memory; Time-based