title: Sustainable Synthesis of Quinolines and Pyrimidines Catalyzed by Manganese PNP Pincer Complexes.
abstract: This study represents the first example an environmentally benign, sustainable, and practical synthesis of substituted quinolines and pyrimidines using combinations of 2-aminobenzyl alcohols and alcohols as well as benzamidine and two different alcohols, respectively. These reactions proceed with high atom efficiency via a sequence of dehydrogenation and condensation steps that give rise to selective C-C and C-N bond formations, thereby releasing 2 equiv of hydrogen and water. A hydride Mn(I) PNP pincer complex recently developed in our laboratory catalyzes this process in a very efficient way. A total of 15 different quinolines and 14 different pyrimidines were synthesized in isolated yields of up to 91 and 90%, respectively.
authors.affiliation: Institute of Applied Synthetic Chemistry and ‡Institute of Chemical Technologies and Analytics, Vienna University of Technology , Getreidemarkt 9, A-1060 Wien, Austria.
authors.forename: Matthias
authors.initials: M
authors.lastname: Mastalir
authors.affiliation: Institute of Applied Synthetic Chemistry and ‡Institute of Chemical Technologies and Analytics, Vienna University of Technology , Getreidemarkt 9, A-1060 Wien, Austria.
authors.forename: Mathias
authors.initials: M
authors.lastname: Glatz
authors.affiliation: Institute of Applied Synthetic Chemistry and ‡Institute of Chemical Technologies and Analytics, Vienna University of Technology , Getreidemarkt 9, A-1060 Wien, Austria.
authors.forename: Ernst
authors.initials: E
authors.lastname: Pittenauer
authors.affiliation: Institute of Applied Synthetic Chemistry and ‡Institute of Chemical Technologies and Analytics, Vienna University of Technology , Getreidemarkt 9, A-1060 Wien, Austria.
authors.forename: Günter
authors.initials: G
authors.lastname: Allmaier
authors.affiliation: Institute of Applied Synthetic Chemistry and ‡Institute of Chemical Technologies and Analytics, Vienna University of Technology , Getreidemarkt 9, A-1060 Wien, Austria.
authors.forename: Karl
authors.initials: K
authors.lastname: Kirchner