title: Individual refinement of attenuation correction maps for hybrid PET/MR based on multi-resolution regional learning.
abstract: PET/MR is an emerging hybrid imaging modality. However, attenuation correction (AC) remains challenging for hybrid PET/MR in generating accurate PET images. Segmentation-based methods on special MR sequences are most widely recommended by vendors. However, their accuracy is usually not high. Individual refinement of available certified attenuation maps may be helpful for further clinical applications. In this study, we proposed a multi-resolution regional learning (MRRL) scheme to utilize the internal consistency of the patient data. The anatomical and AC MR sequences of the same subject were employed to guide the refinement of the provided AC maps. The developed algorithm was tested on 9 patients scanned consecutively with PET/MR and PET/CT (7 [18F]FDG and 2 [18F]FET). The preliminary results showed that MRRL can improve the accuracy of segmented attenuation maps and consequently the accuracy of PET reconstructions.
authors.affiliation: Dept. Nuclear Medicine, Technische Universität München, Munich, Germany. Electronic address: k.shi@tum.de.
authors.forename: Kuangyu
authors.initials: K
authors.lastname: Shi
authors.affiliation: Dept. Nuclear Medicine, Technische Universität München, Munich, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Fürst
authors.affiliation: Microsoft Corporation, Seattle, WA, USA.
authors.forename: Liang
authors.initials: L
authors.lastname: Sun
authors.affiliation: Dept. Nuclear Medicine, Technische Universität München, Munich, Germany.
authors.forename: Mathias
authors.initials: M
authors.lastname: Lukas
authors.affiliation: Chair of Computer-aided Medical Procedure, Dept. Computer Science, Technische Universität München, Munich, Germany.
authors.forename: Nassir
authors.initials: N
authors.lastname: Navab
authors.affiliation: Dept. Nuclear Medicine, Technische Universität München, Munich, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Förster
authors.affiliation: Dept. Nuclear Medicine, Technische Universität München, Munich, Germany.
authors.forename: Sibylle I
authors.initials: SI
authors.lastname: Ziegler
mesh_terms: D000328:Adult; D000465:Algorithms; D001921:Brain / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods*; D000072078:Positron Emission Tomography Computed Tomography; D049268:Positron-Emission Tomography
keywords: Attenuation correction; Machine learning; Multi-resolution; PET/MR