title: Naphthoquinone-Oxindole Alkaloids, Coprisidins A and B, from a Gut-Associated Bacterium in the Dung Beetle, Copris tripartitus.
abstract: Coprisidins A and B (1 and 2) were isolated from a gut-associated Streptomyces sp. in the dung beetle Copris tripartitus. Using a combination of spectroscopic techniques, the structures of the compounds were determined to be the first examples of natural naphthoquinone-oxindole alkaloids. Coprisidin A was found to inhibit the action of Na+/K+-ATPase, and coprisidin B showed activity for the induction of NAD(P)H:quinone oxidoreductase 1.
authors.forename: Soohyun
authors.initials: S
authors.lastname: Um
authors.forename: Duc-Hiep
authors.initials: DH
authors.lastname: Bach
authors.forename: Bora
authors.initials: B
authors.lastname: Shin
authors.forename: Chan-Hong
authors.initials: CH
authors.lastname: Ahn
authors.forename: Seong-Hwan
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Research Policy Bureau , Rural Development Administration, Jeonju, Jeolabuk-do 54875, Republic of Korea.
authors.forename: Hea-Son
authors.initials: HS
authors.lastname: Bang
authors.forename: Ki-Bong
authors.initials: KB
authors.lastname: Oh
authors.forename: Sang Kook
authors.initials: SK
authors.lastname: Lee
authors.forename: Jongheon
authors.initials: J
authors.lastname: Shin
authors.forename: Dong-Chan
authors.initials: DC
authors.lastname: Oh
mesh_terms: D000470:Alkaloids / Q000302:isolation & purification*; D000818:Animals; D001517:Coleoptera / Q000382:microbiology*; D026121:Indole Alkaloids / Q000302:isolation & purification*; D007422:Intestines / Q000382:microbiology*; D015394:Molecular Structure; D009285:Naphthoquinones / Q000302:isolation & purification*; D013302:Streptomyces / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D000470:Alkaloids; D026121:Indole Alkaloids; D009285:Naphthoquinones