title: Rice Bran Extract Reduces the Risk of Atherosclerosis in Post-Menopausal Vietnamese Women.
abstract: We investigated whether pre-germinated brown rice bran extract containing acylated steryl glucosides (PSG) reduces the risk of atherosclerosis in post-menopausal Vietnamese women. A total of 60 post-menopausal Vietnamese women (45-65 y old) with high LDL cholesterol levels (over 140 mg/dL) were randomly divided into PSG (n=30) and placebo (n=30) groups. The subjects in the PSG group were assigned a daily intake of 6 capsules containing 50 mg PSG, and the subjects in the placebo group were assigned a daily intake of 6 capsules containing corn oil for 6 mo. Before baseline and after month 2, month 4, and month 6 of the intervention, we conducted anthropometric measurements, blood biochemical examinations, a nutrition survey, and physical activity, flow-mediated dilation (FMD), and cardio-ankle vascular index (CAVI) measurements. Serum LDL cholesterol concentrations were significantly reduced from 163.6±25.3 (mg/dL) to 135.9±26.8 (mg/dL) compared to the placebo group (p<0.001). FMD values of the placebo group were significantly reduced from 6.6±5.1 (%) to 4.7±2.6 (%) compared to the PSG group (p<0.05). Tumor necrosis factor (TNF)-α concentrations in the PSG group were significantly reduced from 19.8±11 (pg/mL) to 10.6±5.5 (pg/mL) compared to the placebo group (p<0.05). The findings suggest that PSG may improve LDL cholesterol, TNF-α levels, and FMD values. PSG might be considered in reducing the risk of atherosclerosis in post-menopausal Vietnamese women with high LDL cholesterol.
authors.affiliation: National Institute of Nutrition.
authors.forename: Bui Thi
authors.initials: BT
authors.lastname: Nhung
authors.forename: Le Danh
authors.initials: LD
authors.lastname: Tuyen
authors.forename: Vu Anh
authors.initials: VA
authors.lastname: Linh
authors.forename: Nguyen Do Van
authors.initials: ND
authors.lastname: Anh
authors.forename: Tran Thuy
authors.initials: TT
authors.lastname: Nga
authors.forename: Vu Thi Minh
authors.initials: VT
authors.lastname: Thuc
authors.forename: Kei
authors.initials: K
authors.lastname: Yui
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Ito
authors.forename: Yuri
authors.initials: Y
authors.lastname: Nakashima
authors.forename: Shigeru
authors.initials: S
authors.lastname: Yamamoto
mesh_terms: D052242:Adiponectin / Q000097:blood; D000368:Aged; D044466:Asian People; D050197:Atherosclerosis / Q000097:blood / Q000188:drug therapy*; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004043:Dietary Fiber / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D015444:Exercise; D005260:Female; D006801:Humans; D008875:Middle Aged; D009749:Nutrition Surveys; D012275:Oryza / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D017698:Postmenopause; D012307:Risk Factors; D016037:Single-Blind Method; D014280:Triglycerides / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D014744:Vietnam
chemical_list: D052242:Adiponectin; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004043:Dietary Fiber; D010936:Plant Extracts; D014280:Triglycerides; D014409:Tumor Necrosis Factor-alpha