title: Change in Pseudomonas aeruginosa prevalence in cystic fibrosis adults over time.
abstract: Little is known about risk factors for chronic and mucoid Pseudomonas aeruginosa (Pa) infection in cystic fibrosis (CF) adults, and whether the prevalence is changing.
  
  
  
  We employed a retrospective cohort to analyze data from a single adult CF center (2002 to 2012). Regression models were used to assess independent predictors and change in prevalence of chronic and mucoid Pa infection over time.
  
  
  
  The odds ratio of mucoid Pa infection was significantly less in individuals with better baseline lung function (OR 0.84,95%CI:0.77-0.92) and those diagnosed after the age of 25 (OR 0.21, 95%CI:0.05-0.95). The prevalence of chronic Pa and mucoid Pa decreased during the time interval. After adjusting for confounders, the observed decrease in chronic and mucoid Pa between 2002 and 2012 was no longer significant.
  
  
  
  The prevalence of chronic and mucoid Pa is decreasing. Larger studies are needed to confirm these regional trends and their significance.
authors.affiliation: Department of Medicine, University of Washington, Seattle, WA, USA. mrcrull@uw.edu.|University of Washington Medical Center, Campus Box 356522, 1959 N.E. Pacific, Seattle, WA, 98195, USA. mrcrull@uw.edu.
authors.forename: Mathew R
authors.initials: MR
authors.lastname: Crull
authors.affiliation: Department of Medicine, University of Washington, Seattle, WA, USA.
authors.forename: Kathleen J
authors.initials: KJ
authors.lastname: Ramos
authors.affiliation: Department of Medicine, University of Washington, Seattle, WA, USA.
authors.forename: Ellen
authors.initials: E
authors.lastname: Caldwell
authors.affiliation: Department of Pediatrics, Division of Pulmonary, University of Washington, Seattle, WA, USA.|Department of Biostatistics, University of Washington, Seattle, WA, USA.
authors.forename: Nicole
authors.initials: N
authors.lastname: Mayer-Hamblett
authors.affiliation: Department of Medicine, University of Washington, Seattle, WA, USA.
authors.forename: Moira L
authors.initials: ML
authors.lastname: Aitken
authors.affiliation: Department of Medicine, University of Washington, Seattle, WA, USA.|Department of Pediatrics, Division of Pulmonary, University of Washington, Seattle, WA, USA.
authors.forename: Christopher H
authors.initials: CH
authors.lastname: Goss
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003550:Cystic Fibrosis / Q000150:complications* / Q000382:microbiology; D005260:Female; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D010641:Phenotype; D011552:Pseudomonas Infections / Q000188:drug therapy / Q000453:epidemiology*; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification*; D012044:Regression Analysis; D012189:Retrospective Studies; D012307:Risk Factors; D014861:Washington / Q000453:epidemiology; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents
keywords: Chronic infection; Cystic fibrosis; Epidemiology; Pseudomonas aeruginosa; Temporal trends