title: MiR-124 Promotes Newborn Olfactory Bulb Neuron Dendritic Morphogenesis and Spine Density.
abstract: Using microarray analysis, we detected microRNA-124 (miR-124) to be abundantly expressed in the olfactory bulb (OB). miR-124 regulates adult neurogenesis in the subventricular zone (SVZ). However, much less is known about its role in newborn OB neurons. Here, using both gain-of-function and loss-of-function approaches, we demonstrate that brain-specific miR-124 affects dendritic morphogenesis and spine density in newborn OB neurons. Functional Annotation Clustering of miR-124 targets was enriched in "cell morphogenesis involved in neuron differentiation."
authors.affiliation: Department of Neurobiology, Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Guifa
authors.initials: G
authors.lastname: Li
authors.affiliation: Department of Neurobiology, Zhejiang University School of Medicine, Hangzhou, China. lgf198@163.com.
authors.forename: Shucai
authors.initials: S
authors.lastname: Ling
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D049229:Dendritic Spines / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D000071446:Neuronal Outgrowth; D009830:Olfactory Bulb / Q000166:cytology / Q000254:growth & development / Q000378:metabolism*
chemical_list: D035683:MicroRNAs; C540079:Mirn124 microRNA, mouse
keywords: Dendritic; Olfactory bulb; Spine; miR-124