title: Mixed acid-base disorder secondary to topiramate use in traumatic brain injury.
abstract: We report a case of a man with traumatic brain injury. He was started on to prophylactic topiramate which led to a mixed acid-base disorder. He had severe metabolic acidosis secondary to renal tubular acidification defect and respiratory alkalosis secondary to hyperventilation. Withdrawal of the offending drug led to the prompt resolution of the acid-base disturbance.
authors.affiliation: Department of Nephrology, Yashoda Hospitals, Secunderabad, Telangana, India.
authors.forename: S
authors.initials: S
authors.lastname: Golla
authors.affiliation: Department of Nephrology, Yashoda Hospitals, Secunderabad, Telangana, India.
authors.forename: U
authors.initials: U
authors.lastname: Anandh
authors.affiliation: Department of Neurosurgery, Yashoda Hospitals, Secunderabad, Telangana, India.
authors.forename: A
authors.initials: A
authors.lastname: Balasubramaniam
keywords: Metabolic acidosis; respiratory alkalosis; topiramate; traumatic brain injury