title: Fewer self-reported depressive symptoms in young adults exposed to maternal depressed mood during pregnancy.
abstract: Depressed mood is prevalent during pregnancy, with accumulating evidence suggesting an impact on developmental outcome in the offspring. However, the long-term effects of prenatal maternal depression regarding internalizing psychopathology in the offspring are as yet unclear.
  
  
  
  As part of an ongoing epidemiological cohort study, prenatal maternal depressed mood was assessed at the child's age of 3 months. In a sample of n=307 offspring, depressive symptoms were obtained via questionnaire at the ages of 19, 22, 23 and 25 years. At age 25 years, diagnoses of depressive disorder were obtained using a diagnostic interview. In a subsample of currently healthy participants, voxel-based morphometry was conducted and amygdala volume was assessed.
  
  
  
  In n=85 young adults exposed to prenatal maternal depressed mood, no significantly higher risk for a diagnosis of depressive disorder was observed. However, they reported significantly lower levels of depressive symptoms. This association was especially pronounced when prenatal maternal depressed mood was present during the first trimester of pregnancy and when maternal mood was depressed pre- as well as postnatally. At an uncorrected level only, prenatal maternal depressed mood was associated with decreased amygdala volume.
  
  
  
  Prenatal maternal depressed mood was not assessed during pregnancy, but shortly after childbirth. No diagnoses of maternal clinical depression during pregnancy were available.
  
  
  
  Self-reported depressive symptoms do not imply increased, but rather decreased symptom levels in young adults who were exposed to prenatal maternal depressed mood. A long-term perspective may be important when considering consequences of prenatal risk factors.
authors.affiliation: Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim / Heidelberg University, J 5, 68159 Mannheim, Germany.
authors.forename: Katrin
authors.initials: K
authors.lastname: Zohsel
authors.affiliation: Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim / Heidelberg University, J 5, 68159 Mannheim, Germany.
authors.forename: Nathalie E
authors.initials: NE
authors.lastname: Holz
authors.affiliation: Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim / Heidelberg University, J 5, 68159 Mannheim, Germany.
authors.forename: Erika
authors.initials: E
authors.lastname: Hohm
authors.affiliation: Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim / Heidelberg University, J 5, 68159 Mannheim, Germany.
authors.forename: Martin H
authors.initials: MH
authors.lastname: Schmidt
authors.affiliation: Department of Psychology, University of Potsdam, Potsdam, Germany.
authors.forename: Günter
authors.initials: G
authors.lastname: Esser
authors.affiliation: Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim / Heidelberg University, J 5, 68159 Mannheim, Germany; Department of Child and Adolescent Psychiatry, University of Zürich, Zürich, Switzerland; Zurich Center for Integrative Human Physiology, University of Zürich, Zürich, Switzerland; Neuroscience Center Zurich, University and ETH Zürich, Switzerland.
authors.forename: Daniel
authors.initials: D
authors.lastname: Brandeis
authors.affiliation: Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim / Heidelberg University, J 5, 68159 Mannheim, Germany.
authors.forename: Tobias
authors.initials: T
authors.lastname: Banaschewski
authors.affiliation: Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim / Heidelberg University, J 5, 68159 Mannheim, Germany; Department of Psychology, University of Potsdam, Potsdam, Germany. Electronic address: manfred.laucht@zi-mannheim.de.
authors.forename: Manfred
authors.initials: M
authors.lastname: Laucht
mesh_terms: D000328:Adult; D000339:Affect; D015331:Cohort Studies; D003863:Depression / Q000175:diagnosis* / Q000523:psychology; D003866:Depressive Disorder / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications / Q000523:psychology*; D011261:Pregnancy Trimester, First / Q000523:psychology; D011297:Prenatal Exposure Delayed Effects / Q000453:epidemiology* / Q000523:psychology; D057566:Self Report; D011795:Surveys and Questionnaires; D055815:Young Adult