title: Management of primary central nervous system lymphoma in children.
abstract: A 14-year-old boy with no significant past medical history presents with headaches and vomiting and is found to have a 2 × 3-cm left parietal lobe mass. A stereotactic biopsy reveals diffuse large B-cell lymphoma (DLBCL). Cerebrospinal fluid cytology, as well as bone marrow biopsies are negative, and a whole-body positron emission tomography/computed tomography scan does not demonstrate other areas of disease. The primary medical team asks how you would treat this patient.
authors.affiliation: Division of Pediatric Hematology/Oncology, Department of Pediatrics, Weill Cornell Medical College, New York, NY.
authors.forename: Lisa
authors.initials: L
authors.lastname: Giulino-Roth
authors.affiliation: Division of Hematology/Oncology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Canada.
authors.forename: Oussama
authors.initials: O
authors.lastname: Abla
authors.affiliation: Department of Neurology and.|Department of Radiation Oncology, Division of Hematology and Oncology, Massachusetts General Hospital, Boston, MA; and.|Harvard Medical School, Boston, MA.
authors.forename: Tracy T
authors.initials: TT
authors.lastname: Batchelor
mesh_terms: D000293:Adolescent; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000628:therapy; D006801:Humans; D008223:Lymphoma / Q000000981:diagnostic imaging / Q000628:therapy; D008297:Male; D010296:Parietal Lobe / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed