title: Insulin-like Growth Factor 1 gene polymorphism and breast cancer risk.
abstract: Insulin-like Growth Factor-1 (IGF-1) gene polymorphism has been associated with an increased risk for breast cancer. IGF-1 is a key regulator of proliferation, cell differentiation and apoptosis. It has important mitogenic and anti-apoptotic activities in normal cells and in breast cancer cells, acting synergistically with estrogen to increase neoplastic cell proliferation. This review aims to present the recent finds of IGF-1 gene polymorphism and its relationship with the risk of breast cancer through following the polymorphic dinucleotide repeat cytosine-adenine (CA) and single nucleotide polymorphisms (SNPs) by searching in the PubMed database publications focused studies published from 2010 to 2015 related to IGF-1 gene polymorphism and breast cancer risk. A growing number of studies support an association between IGF-1 gene polymorphism and breast cancer risk with conflicting results, nevertheless elucidation of the patterns of IGF-1 gene expression may permit characterization of women at high-risk for breast cancer, as well as the development of strategies for early diagnosis and efficient treatment against the disease.
authors.affiliation: Programa de Pós-Graduação em Ciências e Saúde, Universidade Federal do Piauí, Av. Frei Serafim, 2280, Centro, 64001-020 Teresina, PI, Brazil.
authors.forename: Danylo R
authors.initials: DR
authors.lastname: Costa-Silva
authors.affiliation: Programa de Pós-Graduação em Ciências e Saúde, Universidade Federal do Piauí, Av. Frei Serafim, 2280, Centro, 64001-020 Teresina, PI, Brazil.
authors.forename: Maria DA Conceição
authors.initials: MD
authors.lastname: Barros-Oliveira
authors.affiliation: Setor de Mastologia do Hospital Getulio Vargas, Universidade Federal do Piauí, Av. Frei Serafim, 2352, Centro, 64001-020 Teresina, PI, Brazil.
authors.forename: Rafael S
authors.initials: RS
authors.lastname: Borges
authors.affiliation: Programa de Pós-Graduação em Ciências e Saúde, Universidade Federal do Piauí, Av. Frei Serafim, 2280, Centro, 64001-020 Teresina, PI, Brazil.
authors.forename: Cléciton B
authors.initials: CB
authors.lastname: Tavares
authors.affiliation: Programa de Pós-Graduação em Ciências e Saúde, Universidade Federal do Piauí, Av. Frei Serafim, 2280, Centro, 64001-020 Teresina, PI, Brazil.
authors.forename: Umbelina S
authors.initials: US
authors.lastname: Borges
authors.affiliation: Setor de Mastologia do Hospital Getulio Vargas, Universidade Federal do Piauí, Av. Frei Serafim, 2352, Centro, 64001-020 Teresina, PI, Brazil.
authors.forename: Francisco A
authors.initials: FA
authors.lastname: Alves-Ribeiro
authors.affiliation: Serviço de Biologia Molecular, Hospital Natan Portella, Universidade Federal do Piauí, Rua Governador Raimundo Artur de Vasconcelos, 151, Centro/Sul, 64001-450 Teresina, PI, Brazil.
authors.forename: Vladimir C
authors.initials: VC
authors.lastname: Silva
authors.affiliation: Programa de Pós-Graduação em Ciências e Saúde, Universidade Federal do Piauí, Av. Frei Serafim, 2280, Centro, 64001-020 Teresina, PI, Brazil.|Setor de Mastologia do Hospital Getulio Vargas, Universidade Federal do Piauí, Av. Frei Serafim, 2352, Centro, 64001-020 Teresina, PI, Brazil.
authors.forename: Benedito B DA
authors.initials: BB
authors.lastname: Silva
mesh_terms: D000483:Alleles; D001943:Breast Neoplasms / Q000235:genetics*; D049109:Cell Proliferation; D018900:Dinucleotide Repeats; D005260:Female; D015870:Gene Expression; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: D007334:Insulin-Like Growth Factor I