title: CHANGE OF CHOROIDAL VOLUME IN UNTREATED CENTRAL SEROUS CHORIORETINOPATHY.
abstract: OBJECTIVE
  Choroidal hyperpermeability plays a central role in the pathophysiology of central serous chorioretinopathy (CSC). In active CSC undergoing treatment, choroidal thickness decreases if subretinal fluid (SRF) resolves. This study aimed to investigate the change in choroidal thickness and volume in eyes with untreated CSC.
  
  
  METHODS
  The authors retrospectively analyzed 27 eyes with treatment-naïve CSC (25 patients), who had a follow-up of 4 to 6 weeks. Retinal and choroidal volume and SRF were segmented manually and calculated using the Spectralis OCT built-in software (Spectralis; Heidelberg Engineering).
  
  
  RESULTS
  In treatment-naïve eyes with CSC, an increase in SRF was significantly associated with an increase in choroidal thickness and volume (rho = 0.93, P < 0.01). Eyes with greater baseline choroidal volume showed a significantly greater decrease in SRF during follow-up (rho = -0.47, P = 0.03).
  
  
  CONCLUSIONS
  In this study, an increase in SRF was associated with an increase in both choroidal thickness and volume in eyes with treatment-naïve CSC. Eyes with thicker baseline choroidal volume showed a greater reduction in SRF.
authors.affiliation: Department of Ophthalmology, Medical University of Graz, Graz, Austria.
authors.forename: Laura
authors.initials: L
authors.lastname: Pertl
authors.forename: Anton
authors.initials: A
authors.lastname: Haas
authors.forename: Silke
authors.initials: S
authors.lastname: Hausberger
authors.forename: Tamara
authors.initials: T
authors.lastname: Pichler
authors.forename: Dieter F
authors.initials: DF
authors.lastname: Rabensteiner
authors.forename: Gerald
authors.initials: G
authors.lastname: Seidel
authors.forename: Eva M
authors.initials: EM
authors.lastname: Malle
authors.forename: Martin
authors.initials: M
authors.lastname: Weger
mesh_terms: D000328:Adult; D000368:Aged; D056833:Central Serous Chorioretinopathy / Q000503:physiopathology*; D002829:Choroid / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012160:Retina / Q000503:physiopathology; D012189:Retrospective Studies; D058471:Subretinal Fluid / Q000502:physiology*; D041623:Tomography, Optical Coherence