title: Biogenesis and Transcriptional Regulation of Long Noncoding RNAs in the Human Immune System.
abstract: The central dogma of molecular biology states that DNA makes RNA makes protein. Discoveries over the last quarter of a century found that the process of DNA transcription into RNA gives rise to a diverse array of functional RNA species, including genes that code for protein and noncoding RNAs. For decades, the focus has been on understanding how protein-coding genes are regulated to influence protein expression. However, with the completion of the Human Genome Project and follow-up ENCODE data, it is now appreciated that only 2-3% of the genome codes for protein-coding gene exons and that the bulk of the transcribed genome, apart from ribosomal RNAs, is at the level of noncoding RNA genes. In this article, we focus on the biogenesis and regulation of a distinct class of noncoding RNA molecules termed long, noncoding RNAs in the context of the immune system.
authors.affiliation: Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232; and.
authors.forename: Charles F
authors.identifier: 0000-0001-9015-6321
authors.initials: CF
authors.lastname: Spurlock
authors.affiliation: Department of Mathematics, Vanderbilt University, Nashville, TN 37232.
authors.forename: Philip S
authors.identifier: 0000-0003-3872-3290
authors.initials: PS
authors.lastname: Crooke
authors.affiliation: Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232; and tom.aune@vanderbilt.edu.
authors.forename: Thomas M
authors.identifier: 0000-0002-4968-4306
authors.initials: TM
authors.lastname: Aune
mesh_terms: D000818:Animals; D042002:Chromatin Assembly and Disassembly; D005786:Gene Expression Regulation; D016678:Genome; D006801:Humans; D007107:Immune System; D062085:RNA, Long Noncoding / Q000096:biosynthesis / Q000276:immunology; D014158:Transcription, Genetic
chemical_list: D062085:RNA, Long Noncoding