title: Brugada Syndrome:Risk Stratification And Management.
abstract: The Brugada syndrome (BrS) is an arrhythmogenic disease associated with an increased risk of ventricular fibrillation and sudden cardiac death. The risk stratification and management of BrS patients, particularly of asymptomatic ones, still remains challenging. A previous history of aborted sudden cardiac death or arrhythmic syncope in the presence of spontaneous type 1 ECG pattern of BrS phenotype appear to be the most reliable predictors of future arrhythmic events. Several other ECG parameters have been proposed for risk stratification. Among these ECG markers, QRS-fragmentation appears very promising. Although the value of electrophysiological study still remains controversial, it appears to add important information on risk stratification, particularly when incorporated in multiparametric scores in combination with other known risk factors. The present review article provides an update on the pathophysiology, risk stratification and management of patients with BrS.
authors.affiliation: Laboratory of Cardiac Electrophysiology, "Evangelismos" General Hospital of Athens, Greece.
authors.forename: Konstantinos P
authors.initials: KP
authors.lastname: Letsas
authors.affiliation: Laboratory of Cardiac Electrophysiology, "Evangelismos" General Hospital of Athens, Greece.
authors.forename: Stamatis
authors.initials: S
authors.lastname: Georgopoulos
authors.affiliation: Laboratory of Cardiac Electrophysiology, "Evangelismos" General Hospital of Athens, Greece.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Vlachos
authors.affiliation: Laboratory of Cardiac Electrophysiology, "Evangelismos" General Hospital of Athens, Greece.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Karamichalakis
authors.affiliation: Laboratory of Cardiac Electrophysiology, "Evangelismos" General Hospital of Athens, Greece.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Liatakis
authors.affiliation: Department of Cardiology, University Hospital of Ioannina, Greece.
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Korantzopoulos
authors.affiliation: Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, People's Republic of China.
authors.forename: Tong
authors.initials: T
authors.lastname: Liu
authors.affiliation: Laboratory of Cardiac Electrophysiology, "Evangelismos" General Hospital of Athens, Greece.
authors.forename: Michael
authors.initials: M
authors.lastname: Efremidis
authors.affiliation: Laboratory of Cardiac Electrophysiology, "Evangelismos" General Hospital of Athens, Greece.
authors.forename: Antonios
authors.initials: A
authors.lastname: Sideris
keywords: Brugada syndrome; electrophysiological study; risk stratification; sudden cardiac death