title: Large photoacoustic effect enhancement for ICG confined inside MCM-41 mesoporous silica nanoparticles.
abstract: Indocyanine green was encapsulated inside the pores of pegylated amino-functionalized MCM-41 Mesoporous Silica Nanoparticles (ICG-MSNs). In addition to a greater stability and a decrease of toxicity, the photoacoustic effect of ICG-MSNs increases by nearly 400% compared to free ICG due to fluorescence quenching and high photothermal conversion of the encapsulated dyes. Upon i.v. administration in tumor-bearing mice, an overall photoacoustic enhancement of ca. 25% was measured in the tumor region.
authors.affiliation: Department of Molecular Biotechnology and Health Sciences, University of Turin, Via Nizza 52, 10126 Turin, Italy. silvio.aime@unito.it.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Ferrauto
authors.forename: Fabio
authors.initials: F
authors.lastname: Carniato
authors.forename: Enza
authors.initials: E
authors.lastname: Di Gregorio
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Tei
authors.forename: Mauro
authors.initials: M
authors.lastname: Botta
authors.forename: Silvio
authors.initials: S
authors.lastname: Aime