title: HMMR antisense RNA 1, a novel long noncoding RNA, regulates the progression of basal-like breast cancer cells.
abstract: Recently, accumulating evidence has suggested that long noncoding RNAs (lncRNAs) play crucial roles in carcinogenesis and cancer progression. Hyaluronan-mediated motility receptor (HMMR) is an essential cancer-related gene in basal-like breast cancer (BLBC). In our study, HMMR antisense RNA 1 (HMMR-AS1) was analyzed in BLBC patients through polymerase chain reaction analysis. Here, we found that the expression of HMMR was positively correlated with HMMR-AS1 (RP11-80G.1). When HMMR-AS1 (RP11-80G.1) was knocked down, the expression of HMMR markedly reduced. Furthermore, in MDA-MB-231 and MDA-MB-468 breast cancer cells, the proliferation and migration abilities were remarkably suppressed via knocking down HMMR-AS1 (RP11-80G.1) in vitro. The results showed that lncRNA HMMR-AS1 (RP11-80G.1) influenced the progression of BLBCs through regulating HMMR, suggesting that HMMR-AS1 (RP11-80G.1) could be regarded as a novel biomarker and therapeutic target in the treatment of BLBCs in future.
authors.affiliation: Department of Radiation Oncology, Anhui Provincial Hospital, Hefei, People's Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.affiliation: Department of Radiation Oncology, Anhui Provincial Hospital, Hefei, People's Republic of China.
authors.forename: Jun
authors.initials: J
authors.lastname: Ma
authors.affiliation: Department of Radiation Oncology, Anhui Provincial Hospital, Hefei, People's Republic of China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Cheng
authors.affiliation: Department of Radiation Oncology, Anhui Provincial Hospital, Hefei, People's Republic of China.
authors.forename: Hongbo
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Radiation Oncology, Anhui Provincial Hospital, Hefei, People's Republic of China.
authors.forename: Wengguang
authors.initials: W
authors.lastname: Luo
authors.affiliation: Department of Radiation Oncology, Anhui Provincial Hospital, Hefei, People's Republic of China.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Zhang
keywords: HMMR; HMMR antisense RNA 1; basal-like breast cancer cells; hyaluronan mediated motility receptor; long noncoding RNA