title: Update on the Protective Role of Regulatory T Cells in Myocardial Infarction: A Promising Therapy to Repair the Heart.
abstract: Myocardial infarction (MI) remains one of the leading causes of heart failure development and death worldwide. To date, interventional and pharmacological therapies are effective in reducing the onset of heart failure and promoting survival. However, progressive maladaptive remodeling post-MI persists in a large fraction of patients resulting in poor prognosis. Immune cell responses and an inflammatory environment largely contribute to adverse cardiac remodeling post-MI. CD4FOXP3 regulatory T cells (Tregs) are known for their immunosuppressive capacity and have been successfully implemented in multiple preclinical studies of permanent and ischemia-reperfusion MI. In this review, we highlight the important cardioprotective role of Tregs at the cardiac tissue, cellular, and molecular level, as well as the most prominent pharmacological venues that could be used to exploit Tregs as a novel therapeutic intervention to lessen myocardial injury post-MI.
authors.affiliation: *Department of Pharmacology and Toxicology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon; and†Department of Pharmacology and Toxicology, School of Medicine, University of Mississippi Medical Center, Jackson, MS.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Kaplan
authors.forename: Raffaele
authors.initials: R
authors.lastname: Altara
authors.forename: Ali
authors.initials: A
authors.lastname: Eid
authors.forename: George W
authors.initials: GW
authors.lastname: Booz
authors.forename: Fouad A
authors.initials: FA
authors.lastname: Zouein
mesh_terms: D000818:Animals; D018106:CD28 Antigens / Q000627:therapeutic use; D000068876:Fingolimod Hydrochloride / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology / Q000627:therapeutic use; D009203:Myocardial Infarction / Q000276:immunology* / Q000378:metabolism / Q000517:prevention & control*; D015428:Myocardial Reperfusion Injury / Q000276:immunology / Q000378:metabolism / Q000517:prevention & control; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism; D020257:Ventricular Remodeling / Q000187:drug effects / Q000276:immunology*
chemical_list: D018106:CD28 Antigens; D007166:Immunosuppressive Agents; D000068876:Fingolimod Hydrochloride