title: Effect of E-OJ-01 on Cardiac Conditioning in Young Exercising Adults: A Randomized Controlled Trial.
abstract: OBJECTIVE
  Cardiac health is a determinant of athletic performance. A body of data suggests that in healthy young adults, an increase in maximal cardiac output leads to an increase in endurance. Terminalia arjuna (TA) has been studied for multiple benefits in cardiovascular health although its effects as a cardioprotective ergogenic aid require further exploration. The current trial was planned to study the effect of the proprietary TA extract (E-OJ-01) on the markers of cardiac conditioning in healthy young adults.
  
  
  OBJECTIVE
  No study has assessed the effect of TA extract on cardiac conditioning by improvement of left ventricular ejection fraction (LVEF) in young exercising individuals.
  A randomized, double-blind, placebo-controlled, parallel group study was conducted to determine the efficacy and safety of E-OJ-01 for use as an ergogenic supplements in young exercising adults. This trial was registered at ClinicalTrials.gov (NCT02207101) and reported according to Consolidated Standards of Reporting Trials (CONSORT) requirements. Thirty-two healthy males, aged 18-40 years performing regular endurance exercise, were randomly assigned to 400 mg of E-OJ-01 or placebo for 56 days. LVEF, right and left ventricular Myocardial Performance Index, and Borg Rated Perceived Exertion (RPE) were assessed at baseline, day 28, and day 56; creatine kinase-MB and troponin-T were assessed at baseline and at day 56.
  
  
  RESULTS
  As compared with placebo, 56 days of E-OJ-01 supplementation significantly improved the LVEF (P = 0.0001) and decreased the right ventricular Myocardial Performance Index (P = 0.001). The fatigue level captured by Borg Scale after completion of exercise showed a greater decrease in the E-OJ-01 group as compared with placebo. Creatine kinase-MB and troponin-T did not change significantly.
  
  
  CONCLUSIONS
  TA (E-OJ-01) significantly increased cardiovascular efficiency and improved the cardiac conditioning in young healthy adults.
authors.affiliation: 1Department of Biological Sciences, University of Southern California, Los Angeles, CA; and 2New Product Research & Development, Enovate Biolife, Wilmington, DE.
authors.forename: Robert N
authors.initials: RN
authors.lastname: Girandola
authors.forename: Shalini
authors.initials: S
authors.lastname: Srivastava
mesh_terms: D000293:Adolescent; D000328:Adult; D052279:Creatine Kinase, MB Form / Q000378:metabolism; D019587:Dietary Supplements; D004311:Double-Blind Method; D015444:Exercise; D006321:Heart / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008297:Male; D010807:Physical Endurance / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D029766:Terminalia / Q000737:chemistry*; D020107:Troponin T / Q000378:metabolism; D016277:Ventricular Function, Left / Q000187:drug effects*; D055815:Young Adult
chemical_list: D010936:Plant Extracts; D020107:Troponin T; D052279:Creatine Kinase, MB Form