title: A Retrospective Analysis of Toxicity and Efficacy for 2 Hypofractionated Irradiation Schedules Versus a Conventional One for Post-Mastectomy Adjuvant Radiotherapy in Breast Cancer.
abstract: BACKGROUND
  The aim of this analysis was a retrospective evaluation of the efficacy and toxicity of 2 hypofractionated irradiation schedules compared to conventional therapy in post-mastectomy patients.
  
  
  METHODS
  3 irradiation schedules were analyzed: 48.30 Gy in 21 fractions (group A, n = 60), 42.56 Gy in 16 fractions (group B, n = 27) and 50 Gy in 25 fractions (group C, n = 30) of the front chest wall. All groups were also treated with a supraclavicular field, with 39.10 Gy in 17 fractions (group A), 37.24 Gy in 14 fractions (group B) or 45 Gy in 25 fractions (group C).
  
  
  RESULTS
  No local recurrences were noted in any group during 36 months of follow-up. Acute skin toxicity presented in all groups, with 58.3%, 70.4% and 60% of grade I; 35%, 25.9% and 40% of grade II; 6.7%, 3.7% and 0% of grade III being seen in groups A, B and C, respectively. Late skin toxicity was noted only as grade I in 16.7%, 25.9% and 26.7% of groups A, B and C, respectively. No significant difference was noted among all groups for either acute or late skin toxicity, or for radio-pneumonitis (chi2test,p> 0.05).
  
  
  CONCLUSIONS
  All schedules were equally effective with equivalent toxicity. A prospective randomized study is needed to confirm our results.
authors.affiliation: Radiotherapy Unit, 2nd Department of Radiology, Medical School, ATTIKON University Hospital, Athens, Greece, Athens, Greece; Radiotherapy Unit, 1st Department of Radiology, Medical School, Aretaieion University Hospital, Athens, Greece, Athens, Greece.
authors.forename: Vassilis
authors.initials: V
authors.lastname: Kouloulias
authors.affiliation: Radiotherapy Unit, 2nd Department of Radiology, Medical School, ATTIKON University Hospital, Athens, Greece, Athens, Greece.
authors.forename: Eftychia
authors.initials: E
authors.lastname: Mosa
authors.affiliation: Radiotherapy Unit, 1st Department of Radiology, Medical School, Aretaieion University Hospital, Athens, Greece, Athens, Greece.
authors.forename: Anna
authors.initials: A
authors.lastname: Zygogianni
authors.affiliation: Radiotherapy Unit, 2nd Department of Radiology, Medical School, ATTIKON University Hospital, Athens, Greece, Athens, Greece.
authors.forename: Efrosini
authors.initials: E
authors.lastname: Kypraiou
authors.affiliation: Radiotherapy Unit, 2nd Department of Radiology, Medical School, ATTIKON University Hospital, Athens, Greece, Athens, Greece.
authors.forename: John
authors.initials: J
authors.lastname: Georgakopoulos
authors.affiliation: Radiotherapy Unit, 2nd Department of Radiology, Medical School, ATTIKON University Hospital, Athens, Greece, Athens, Greece.
authors.forename: Kalliopi
authors.initials: K
authors.lastname: Platoni
authors.affiliation: Radiotherapy Unit, 1st Department of Radiology, Medical School, Aretaieion University Hospital, Athens, Greece, Athens, Greece.
authors.forename: Christos
authors.initials: C
authors.lastname: Antypas
authors.affiliation: Radiotherapy Department, Medical School of Thessaly, University Hospital of Larisa, Larisa, Greece, Athens, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Kyrgias
authors.affiliation: Radiotherapy Unit, 1st Department of Radiology, Medical School, Aretaieion University Hospital, Athens, Greece, Athens, Greece; Radiotherapy Department, Medical School of Thessaly, University Hospital of Larisa, Larisa, Greece, Athens, Greece.
authors.forename: Maria
authors.initials: M
authors.lastname: Tolia
authors.affiliation: Therapeutics Clinic, Alexandra Hospital, Medical School of Athens, Athens, Greece, Athens, Greece.
authors.forename: Christos
authors.initials: C
authors.lastname: Papadimitriou
authors.affiliation: Medical Oncology Unit, ATTIKON University Hospital, Athens, Greece.
authors.forename: Amanda
authors.initials: A
authors.lastname: Psyrri
authors.affiliation: Radiotherapy Unit, 2nd Department of Radiology, Medical School, ATTIKON University Hospital, Athens, Greece, Athens, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Patatoukas
authors.affiliation: Radiotherapy Unit, 2nd Department of Radiology, Medical School, ATTIKON University Hospital, Athens, Greece, Athens, Greece.
authors.forename: Maria
authors.initials: M
authors.lastname: Dilvoi
authors.affiliation: Radiotherapy Unit, 1st Department of Radiology, Medical School, Aretaieion University Hospital, Athens, Greece, Athens, Greece.
authors.forename: Christina
authors.initials: C
authors.lastname: Armpilia
authors.affiliation: Radiotherapy Department, Medical School of Thessaly, University Hospital of Larisa, Larisa, Greece, Athens, Greece.
authors.forename: Kyriaki
authors.initials: K
authors.lastname: Theodorou
authors.affiliation: Radiotherapy Department, Medical School of Thessaly, University Hospital of Larisa, Larisa, Greece, Athens, Greece.
authors.forename: Maria-Aggeliki
authors.initials: MA
authors.lastname: Kalogeridi
authors.affiliation: Radiotherapy Unit, 2nd Department of Radiology, Medical School, ATTIKON University Hospital, Athens, Greece, Athens, Greece.
authors.forename: Ivelina
authors.initials: I
authors.lastname: Beli
authors.affiliation: Radiotherapy Unit, 1st Department of Radiology, Medical School, Aretaieion University Hospital, Athens, Greece, Athens, Greece.
authors.forename: John
authors.initials: J
authors.lastname: Kouvaris
authors.affiliation: Radiotherapy Unit, 2nd Department of Radiology, Medical School, ATTIKON University Hospital, Athens, Greece, Athens, Greece.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Kelekis
keywords: Breast cancer; Efficacy; Hypofractionation; Postmastectomy irradiation; Toxicity