title: Turning Diamagnetic Microbes into Multinary Micro-Magnets: Magnetophoresis and Spatio-Temporal Manipulation of Individual Living Cells.
abstract: Inspired by the biogenic magnetism found in certain organisms, such as magnetotactic bacteria, magnetic nanomaterials have been integrated into living cells for bioorthogonal, magnetic manipulation of the cells. However, magnetized cells have so far been reported to be only binary system (on/off) without any control of magnetization degree, limiting their applications typically to the simple accumulation or separation of cells as a whole. In this work, the magnetization degree is tightly controlled, leading to the generation of multiple subgroups of the magnetized cells, and each subgroup is manipulated independently from the other subgroups in the pool of heterogeneous cell-mixtures. This work will provide a strategic approach to tailor-made fabrication of magnetically functionalized living cells as micro-magnets, and open new vistas in biotechnological and biomedical applications, which highly demand the spatio-temporal manipulation of living cells.
authors.affiliation: Center for Cell-Encapsulation Research, Department of Chemistry, KAIST, Daejeon 34141, Korea.
authors.forename: Hojae
authors.initials: H
authors.lastname: Lee
authors.affiliation: Center for Cell-Encapsulation Research, Department of Chemistry, KAIST, Daejeon 34141, Korea.
authors.forename: Daewha
authors.initials: D
authors.lastname: Hong
authors.affiliation: Center for Cell-Encapsulation Research, Department of Chemistry, KAIST, Daejeon 34141, Korea.
authors.forename: Hyeoncheol
authors.initials: H
authors.lastname: Cho
authors.affiliation: Center for Cell-Encapsulation Research, Department of Chemistry, KAIST, Daejeon 34141, Korea.
authors.forename: Ji Yup
authors.initials: JY
authors.lastname: Kim
authors.affiliation: Center for Cell-Encapsulation Research, Department of Chemistry, KAIST, Daejeon 34141, Korea.
authors.forename: Ji Hun
authors.initials: JH
authors.lastname: Park
authors.affiliation: Graduate School of Medical Science and Engineering, KAIST, Daejeon 34141, Korea.
authors.forename: Sang Hee
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Graduate School of Medical Science and Engineering, KAIST, Daejeon 34141, Korea.
authors.forename: Ho Min
authors.initials: HM
authors.lastname: Kim
authors.affiliation: Bionanotechnology Lab, Institute of Fundamental Medicine &Biology, Kazan Federal University, Kreml uramı 18, Kazan, Republic of Tatarstan 420008, Russian Federation.
authors.forename: Rawil F
authors.initials: RF
authors.lastname: Fakhrullin
authors.affiliation: Center for Cell-Encapsulation Research, Department of Chemistry, KAIST, Daejeon 34141, Korea.
authors.forename: Insung S
authors.initials: IS
authors.lastname: Choi
mesh_terms: D006046:Gold / Q000494:pharmacology; D008280:Magnetics; D012441:Saccharomyces cerevisiae / Q000166:cytology*; D012822:Silicon Dioxide / Q000494:pharmacology; D013997:Time Factors
chemical_list: D006046:Gold; D012822:Silicon Dioxide