title: Nuclear expression and/or reduced membranous expression of β-catenin correlate with poor prognosis in colorectal carcinoma: A meta-analysis.
abstract: BACKGROUND
  The differential subcellular localizations of β-catenin (including membrane, cytoplasm, and nucleus) play different roles in the progression of colorectal cancer (CRC). However, the correlation between each subcellular localization of β-catenin and the prognosis of CRC patients remains undetermined.
  
  
  METHODS
  Systematic strategies were applied to search for eligible published studies in the PubMed, Embase, and Web of Science databases. The correlation between each subcellular localizations of β-catenin expression and patients' clinicopathological features or prognosis was analyzed.
  
  
  RESULTS
  Finally, this meta-analysis, including 6238 cases from 34 studies, revealed that β-catenin overexpression in the nucleus (HR: 1.50[95% CI: 1.08-2.10]) or reduced expression of β-catenin in the membrane (HR: 1.33[95% CI: 1.15-1.54]) significantly correlated with lower 5-year overall survival (OS). Conversely, overexpression of β-catenin in the cytoplasm (HR: 1.00[95% CI: 0.85-1.18]) did not show significant association with 5-year OS.
  
  
  CONCLUSIONS
  This study suggested that β-catenin overexpression in the nucleus or reduced expression in the membrane, but not its overexpression in cytoplasm, could serve as a valuable prognostic predictor for CRC. However, additional large and well-designed prospective studies are required to verify our results.
authors.affiliation: Department of Oncology and Cancer Institute (Key Laboratory of Cancer Prevention & Intervention, National Ministry of Education, Provincial Key Laboratory of Molecular Biology in Medical Sciences), Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China Division of Hematopoietic Stem Cell and Leukemia Research, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA Department of Plastic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou Department of surgical oncology, Third Affiliate Hospital of Wenzhou Medical University, Wenzhou Department of Reproductive, Integrated Chinese and Western Medicine Hospital of Zhejiang Province, Hangzhou, China.
authors.forename: Shizhen
authors.initials: S
authors.lastname: Zhang
authors.forename: Zhen
authors.initials: Z
authors.lastname: Wang
authors.forename: Jinlan
authors.initials: J
authors.lastname: Shan
authors.forename: Xiuyan
authors.initials: X
authors.lastname: Yu
authors.forename: Ling
authors.initials: L
authors.lastname: Li
authors.forename: Rui
authors.initials: R
authors.lastname: Lei
authors.forename: Daozhe
authors.initials: D
authors.lastname: Lin
authors.forename: Siqi
authors.initials: S
authors.lastname: Guan
authors.forename: Xiaochen
authors.initials: X
authors.lastname: Wang
mesh_terms: D015179:Colorectal Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D018450:Disease Progression; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009367:Neoplasm Staging; D051176:beta Catenin / Q000235:genetics*
chemical_list: D051176:beta Catenin