title: The role of platelet microvesicles in intercellular communication.
abstract: In recent years, there has been exponential growth in the interest in microvesicles, which is reflected by the number of publications. Initially referred to as "platelet dust" by Peter Wolf in 1967, platelet microvesicles (PMV) are now recognized as important mediators of intercellular communication. There are examples of PMV exerting physiological effects on almost all hematological and vascular cell types, including monocytes, macrophages, neutrophils, T-cells, endothelium cells, and smooth muscle cells (SMCs). PMV can exert these effects by multiple methods: extracellular signaling through receptors, transfer of surface molecules, and delivery of intracellular contents including miRNA. Recent work suggests a complex environment in which cellular contents are being shared multi-directionally between multiple cell types. This review will focus on the communicative properties of PMV.
authors.affiliation: a Cardeza Foundation for Hematologic Research, Department of Medicine , Thomas Jefferson University , Philadelphia , PA , USA.
authors.forename: Leonard C
authors.initials: LC
authors.lastname: Edelstein
mesh_terms: D016718:Arachidonic Acid / Q000378:metabolism; D001792:Blood Platelets / Q000166:cytology / Q000378:metabolism*; D002450:Cell Communication / Q000502:physiology*; D055252:Cell-Derived Microparticles / Q000737:chemistry / Q000378:metabolism*; D042783:Endothelial Cells / Q000166:cytology / Q000378:metabolism; D006801:Humans; D008264:Macrophages / Q000166:cytology / Q000378:metabolism; D035683:MicroRNAs / Q000378:metabolism; D009000:Monocytes / Q000166:cytology / Q000378:metabolism; D032389:Myocytes, Smooth Muscle / Q000166:cytology / Q000378:metabolism; D009504:Neutrophils / Q000166:cytology / Q000378:metabolism; D010973:Platelet Adhesiveness / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D013601:T-Lymphocytes / Q000166:cytology / Q000378:metabolism; D013928:Thromboxane A2 / Q000378:metabolism
chemical_list: D035683:MicroRNAs; D016718:Arachidonic Acid; D013928:Thromboxane A2
keywords: communication; miRNA; microvesicles; platelets