title: Locally advanced carcinoma of the cervix associated with pelvic kidney treated with intensity-modulated radiotherapy: Overcoming a therapeutic challenge.
abstract: The simultaneous occurrence of carcinoma of the cervix and pelvic kidney is rare. As the pelvic kidney occupies the conventional radiation portal for carcinoma of the cervix, treatment of these patients with radiation presents a therapeutic challenge. A 48-year-old stage IIIB cervical carcinoma patient with an incidental diagnosis of pelvic kidney was treated with radical chemoradiotherapy using intensity-modulated radiotherapy with concurrent weekly cisplatin, followed by intracavitary radiotherapy. The bilateral kidney dose was restricted within a tolerance limit of 16.6 Gy. At the 18-month follow-up, the patient was disease free and had no deterioration in kidney function. Intensity-modulated radiotherapy provided the necessary means for delivering radical radiation doses in this case scenario with adequate sparing of the kidney.
authors.affiliation: Department of Radiation Oncology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Lakhan
authors.initials: L
authors.lastname: Kashyap
authors.affiliation: Department of Radiation Oncology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Ajeet Kumar
authors.identifier: http://orcid.org/0000-0001-5713-0963
authors.initials: AK
authors.lastname: Gandhi
authors.affiliation: Department of Radiation Oncology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Rambha
authors.initials: R
authors.lastname: Pandey
authors.affiliation: Department of Radiation Oncology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Daya Nand
authors.initials: DN
authors.lastname: Sharma
mesh_terms: D059248:Chemoradiotherapy / Q000379:methods; D003287:Contrast Media; D019583:Dose Fractionation, Radiation; D005260:Female; D006801:Humans; D007668:Kidney / Q000002:abnormalities* / Q000000981:diagnostic imaging; D007674:Kidney Diseases / Q000150:complications* / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D008875:Middle Aged; D009367:Neoplasm Staging; D017698:Postmenopause; D050397:Radiotherapy, Intensity-Modulated / Q000379:methods*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology / Q000532:radiotherapy*
chemical_list: D003287:Contrast Media
keywords: cervical cancer; chemoradiotherapy; intensity-modulated radiotherapy; pelvic kidney