title: Allele rs2010963 C of the VEGFA gene is associated with the decreased risk of primary varicose veins in ethnic Russians.
abstract: Objective To study the association of polymorphisms rs699947, rs2010963, rs3025039 in the VEGFA gene region and rs1870377, rs2305949, rs2071559 in the VEGFR2 gene region with the risk of primary varicose veins in ethnic Russians. Methods Genotypes were determined by real-time PCR allelic discrimination. The case group consisted of 448 patients with primary varicose veins and the control group comprised 609 individuals without a history of chronic venous disease. Association was studied by logistic regression analysis. Results Allele rs2010963 C was associated with the decreased risk of varicose veins (additive model of inheritance: odds ratio = 0.73, 95% confidence interval = 0.59-0.91, P = 0.004). Conclusions Our results provide evidence that polymorphism rs2010963 located in the 5' untranslated region of the VEGFA gene can influence genetic susceptibility to primary varicose veins in Russians. Otherwise, it can be in linkage disequilibrium with another functional single nucleotide polymorphism that can alter the level of vascular endothelial growth factor A protein.
authors.affiliation: 1 Institute of Chemical Biology and Fundamental Medicine, Russia.|2 Novosibirsk State University, Russia.
authors.forename: Alexandra S
authors.initials: AS
authors.lastname: Shadrina
authors.affiliation: 1 Institute of Chemical Biology and Fundamental Medicine, Russia.
authors.forename: Mariya A
authors.initials: MA
authors.lastname: Smetanina
authors.affiliation: 1 Institute of Chemical Biology and Fundamental Medicine, Russia.|2 Novosibirsk State University, Russia.
authors.forename: Ekaterina A
authors.initials: EA
authors.lastname: Sokolova
authors.affiliation: 1 Institute of Chemical Biology and Fundamental Medicine, Russia.
authors.forename: Darya V
authors.initials: DV
authors.lastname: Shamovskaya
authors.affiliation: 1 Institute of Chemical Biology and Fundamental Medicine, Russia.
authors.forename: Kseniya S
authors.initials: KS
authors.lastname: Sevost'ianova
authors.affiliation: 1 Institute of Chemical Biology and Fundamental Medicine, Russia.
authors.forename: Andrey I
authors.initials: AI
authors.lastname: Shevela
authors.affiliation: 3 Pirogov Russian National Research Medical University, Russia.
authors.forename: Evgenii Y
authors.initials: EY
authors.lastname: Soldatsky
authors.affiliation: 3 Pirogov Russian National Research Medical University, Russia.
authors.forename: Evgenii I
authors.initials: EI
authors.lastname: Seliverstov
authors.affiliation: 4 Private Surgery Center "Medalp", Russia.
authors.forename: Marina Y
authors.initials: MY
authors.lastname: Demekhova
authors.affiliation: 4 Private Surgery Center "Medalp", Russia.
authors.forename: Oleg A
authors.initials: OA
authors.lastname: Shonov
authors.affiliation: 4 Private Surgery Center "Medalp", Russia.
authors.forename: Evgeny A
authors.initials: EA
authors.lastname: Ilyukhin
authors.affiliation: 1 Institute of Chemical Biology and Fundamental Medicine, Russia.|2 Novosibirsk State University, Russia.
authors.forename: Elena N
authors.initials: EN
authors.lastname: Voronina
authors.affiliation: 5 Novosibirsk State Medical University, Russia.
authors.forename: Ilya V
authors.initials: IV
authors.lastname: Pikalov
authors.affiliation: 3 Pirogov Russian National Research Medical University, Russia.
authors.forename: Igor A
authors.initials: IA
authors.lastname: Zolotukhin
authors.affiliation: 3 Pirogov Russian National Research Medical University, Russia.
authors.forename: Alexander I
authors.initials: AI
authors.lastname: Kirienko
authors.affiliation: 1 Institute of Chemical Biology and Fundamental Medicine, Russia.|2 Novosibirsk State University, Russia.
authors.forename: Maxim L
authors.initials: ML
authors.lastname: Filipenko
mesh_terms: D020121:5' Untranslated Regions; D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D065840:Protective Factors; D012307:Risk Factors; D012426:Russia / Q000453:epidemiology; D014648:Varicose Veins / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics*; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000235:genetics; D055815:Young Adult
chemical_list: D020121:5' Untranslated Regions; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; C000588866:KDR protein, human; D040301:Vascular Endothelial Growth Factor Receptor-2
keywords: Russians; Varicose veins; association; single nucleotide polymorphism; vascular endothelial growth factor