title: Impact of Left Heart Bypass on Arterial Oxygenation During One-Lung Ventilation for Thoracic Aortic Surgery.
abstract: OBJECTIVE
  The aim of this study was to reveal the mechanism of improved arterial oxygenation by measuring the changes in oxygenation before and after initiation of left heart bypass (LHB) during one-lung ventilation (OLV) for thoracic aortic surgery.
  
  
  METHODS
  Prospective, observational study.
  
  
  METHODS
  Single-institution, private hospital.
  
  
  METHODS
  The study comprised 50 patients who underwent aortic surgery via a left thoracotomy approach with LHB circulatory support.
  
  
  METHODS
  Patients were ventilated using pure oxygen during OLV, and the ventilator setting was left unchanged during the measurement period.
  
  
  RESULTS
  The measurement of partial pressure of arterial oxygen (PaO2) was made at the following 4 time points: 2 minutes after heparin infusion (point 1 [P1]), 2 minutes after inflow cannula insertion through the left pulmonary vein (P2), immediately before LHB initiation (P3), and 10 minutes after LHB initiation (P4). The mean±standard deviation (mmHg) of PaO2measurements at the P1, P2, P3, and P4 time points were 244±121, 250±123, 419±122, and 430±109, respectively, with significant increases between P1 and P3, P1 and P4, P2 and P3, and P2 and P4 (p<0.0001, respectively). No significant increase in PaO2was seen between P1 and P2 or between P3 and P4.
  
  
  CONCLUSIONS
  The improved arterial oxygenation during OLV in patients who underwent thoracic aortic surgery using LHB can be attributed to the insertion of an inflow cannula via the left pulmonary vein into the left atrium before LHB.
authors.affiliation: Department of Anesthesia, Kawasaki Municipal Hospital, Kanagawa, Japan; Department of Anesthesiology, Toho University, School of Medicine, Tokyo, Japan. Electronic address: kikuko-suga@ktb.biglobe.ne.jp.
authors.forename: Kikuko
authors.initials: K
authors.lastname: Suga
authors.affiliation: Department of Anesthesia, National Hospital Organization Tokyo Medical Center, Tokyo, Japan.
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Kobayashi
authors.affiliation: Department of Anesthesiology, Toho University, School of Medicine, Tokyo, Japan.
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Ochiai
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001013:Aorta, Thoracic / Q000378:metabolism* / Q000601:surgery; D002407:Catheterization, Swan-Ganz / Q000379:methods / Q000639:trends*; D005260:Female; D018611:Heart Bypass, Left / Q000379:methods / Q000639:trends*; D006801:Humans; D008297:Male; D008875:Middle Aged; D061810:One-Lung Ventilation / Q000379:methods / Q000639:trends*; D010092:Oximetry / Q000379:methods / Q000639:trends; D010100:Oxygen / Q000378:metabolism*; D011446:Prospective Studies; D013908:Thoracotomy / Q000379:methods / Q000639:trends*
chemical_list: D010100:Oxygen
keywords: inflow cannula; left heart bypass; one-lung ventilation; oxygenation; pulmonary blood flow