title: Rehabilitation in Chronic Graft-Versus-Host Disease.
abstract: Chronic graft-versus-host disease is a potentially debilitating complication of allogeneic hematopoietic stem cell transplantation. Due to the direct inflammatory effects of the disease on tissue, and the impact on muscle and bone of the high-dose glucocorticoid immunosuppression used to treat the disease, patients are at risk of developing multifactorial functional impairment. This review outlines the clinical assessment and rehabilitation interventions to manage aspects of the disease that cause the most impairment: involvement of the skin/fascial and cardiopulmonary organ systems, as well as steroid-induced myopathy and bone and joint destruction.
authors.affiliation: Department of Physical Medicine & Rehabilitation, University of Michigan, 325 East Eisenhower Pkwy, Suite 100, Ann Arbor, MI 48108, USA. Electronic address: srsz@med.umich.edu.
authors.forename: Sean Robinson
authors.initials: SR
authors.lastname: Smith
authors.affiliation: Department of Physical Medicine & Rehabilitation, Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center, Health Sciences, UCLA, 8700 Beverly Boulevard, AC 1109, Los Angeles, CA 90048, USA.
authors.forename: Arash
authors.initials: A
authors.lastname: Asher
mesh_terms: D002908:Chronic Disease; D006086:Graft vs Host Disease / Q000209:etiology / Q000534:rehabilitation* / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans
keywords: Bone marrow transplant rehabilitation; Cancer rehabilitation; Chronic graft-versus-host disease; GVHD; GVHD rehabilitation