title: Antibodies Against the Current Influenza A(H1N1) Vaccine Strain Do Not Protect Some Individuals From Infection With Contemporary Circulating Influenza A(H1N1) Virus Strains.
abstract: During the 2013-2014 influenza season, nearly all circulating 2009 pandemic influenza A(H1N1) virus (A[H1N1]pdm09) strains possessed an antigenically important mutation in hemagglutinin (K166Q). Here, we performed hemagglutination-inhibition (HAI) assays, using sera collected from 382 individuals prior to the 2013-2014 season, and we determined whether HAI titers were associated with protection from A(H1N1)pdm09 infection. Protection was associated with HAI titers against an A(H1N1)pdm09 strain possessing the K166Q mutation but not with HAI titers against the current A(H1N1)pdm09 vaccine strain, which lacks this mutation. These data indicate that contemporary A(H1N1)pdm09 strains are antigenically distinct from the current A(H1N1)pdm09 vaccine strain.
authors.affiliation: Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor.
authors.forename: Joshua G
authors.initials: JG
authors.lastname: Petrie
authors.affiliation: Wistar Institute.|Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia.
authors.forename: Kaela
authors.initials: K
authors.lastname: Parkhouse
authors.affiliation: Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor.
authors.forename: Suzanne E
authors.initials: SE
authors.lastname: Ohmit
authors.affiliation: Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor.
authors.forename: Ryan E
authors.initials: RE
authors.lastname: Malosh
authors.affiliation: Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor.
authors.forename: Arnold S
authors.initials: AS
authors.lastname: Monto
authors.affiliation: Wistar Institute.|Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia.
authors.forename: Scott E
authors.initials: SE
authors.lastname: Hensley
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood*; D056738:Cross Protection; D005260:Female; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology*; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000276:immunology*; D007251:Influenza, Human / Q000276:immunology / Q000517:prevention & control* / Q000821:virology*; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D007252:Influenza Vaccines
keywords: antigenic drift; correlates of protection; hemagglutinin; household cohort; influenza; influenza vaccine; pandemic H1N1; serum antibody