title: Prognostic value of non-high-density lipoprotein cholesterol for mortality in patients with coronary heart disease: A systematic review and meta-analysis.
abstract: OBJECTIVE
  Recent studies have indicated the predictive value of non-high-density lipoprotein cholesterol (non-HDL-C) for mortality in patients without coronary heart disease (CHD). However, its independent prognostic value on patients with CHD has yet been explored. The purpose of this study was to investigate whether non-HDL-C could predict long-term mortality in patients with CHD.
  
  
  METHODS
  A comprehensive search for literature was performed in several database, including Medline, the Cochrane library, Embase and 3 Chinese databases. Studies were included if they reported risk estimation of mortality on CHD patients. Pooled risk ratios (RRs) and 95% confidence interval (CI) were calculated to assess the association. We performed sensitivity analyses to explore the potential sources of heterogeneity. Statistical analyses were carried out by Stata 12.0.
  
  
  RESULTS
  After screening 533 studies, 6 trials (follow up range from 18 to 148months) enrolling 11,057 CHD patients were included. CHD patients with high non-HDL-C level at baseline was associated with higher risk of mortality (RR: 1.24, 95%CI: 1.05-1.46, p: 0.011). Results from continuous analyze showed that each 10mg/dl increase in non-HDL-C was associated with an increased risk of mortality in CHD patients (RR: 1.13, 95%CI: 1.06-1.21, p<0.001).
  
  
  CONCLUSIONS
  The increased levels of non-HDL-C were significantly associated with an increased risk of mortality on CHD patients. Baseline non-HDL-C levels might be a practical predictor of long-term death in patients with CHD.
authors.affiliation: Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, China; The 2nd Clinical College of Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
authors.forename: Pengda
authors.initials: P
authors.lastname: Liao
authors.affiliation: Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, China; The 2nd Clinical College of Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
authors.forename: Ruixiang
authors.initials: R
authors.lastname: Zeng
authors.affiliation: Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, China.
authors.forename: Xujie
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, China.
authors.forename: Liheng
authors.initials: L
authors.lastname: Guo
authors.affiliation: Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, China; The 2nd Clinical College of Guangzhou University of Chinese Medicine, Guangzhou 510405, China. Electronic address: minzhouzhang@aliyun.com.
authors.forename: Minzhou
authors.initials: M
authors.lastname: Zhang
mesh_terms: D015415:Biomarkers / Q000097:blood; D002784:Cholesterol / Q000097:blood*; D003327:Coronary Disease / Q000097:blood* / Q000175:diagnosis / Q000401:mortality*; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008137:Longitudinal Studies; D009026:Mortality / Q000639:trends; D064887:Observational Studies as Topic / Q000379:methods; D011379:Prognosis; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic / Q000379:methods
chemical_list: D015415:Biomarkers; D008074:Lipoproteins; C030104:lipoprotein cholesterol; D002784:Cholesterol
keywords: Coronary heart disease; Mortality; Non-high-density lipoprotein cholesterol; Prognostic value