title: [Core principles of treatment of corneal damage in patients with thyroid eye disease].
abstract: OBJECTIVE
  To develop a therapeutic approach and to estimate the efficiency of complex treatment of corneal damage in patients with thyroid eye disease (TED).
  
  
  METHODS
  The study enrolled 44 patients (52 eyes) divided into 2 groups depending on the severity of corneal damage. Treatment of those with severe involvement included pathogenetic measures (pulse steroid therapy and/or radiation therapy) and surgery (orbital decompression, eyelid and corneal surgery).
  
  
  RESULTS
  As the result of the treatment, orbital inflammation decreased and the state of the cornea improved in all patients.
  
  
  CONCLUSIONS
  The treatment of corneal damage in patients with TED may differ depending on numerous factors, such as the severity of corneal damage and activity of orbital inflammation. Taking into account the potential danger of corneal involvement, one should make efforts to early detection and management of the risk factors.
authors.affiliation: Research Institute of Eye Diseases, 11 A, B Rossolimo St., Moscow, Russian Federation, 119021; I.M.Sechenov First Moscow State Medical University, Ophthalmology Department, 2-4 Bol'shaya Pirogovskaya St., Moscow, Russian Federation, 119991.
authors.forename: Y O
authors.initials: YO
authors.lastname: Grusha
authors.affiliation: Research Institute of Eye Diseases, 11 A, B Rossolimo St., Moscow, Russian Federation, 119021; I.M.Sechenov First Moscow State Medical University, Ophthalmology Department, 2-4 Bol'shaya Pirogovskaya St., Moscow, Russian Federation, 119991.
authors.forename: D S
authors.initials: DS
authors.lastname: Ismailova
authors.affiliation: Research Institute of Eye Diseases, 11 A, B Rossolimo St., Moscow, Russian Federation, 119021; I.M.Sechenov First Moscow State Medical University, Ophthalmology Department, 2-4 Bol'shaya Pirogovskaya St., Moscow, Russian Federation, 119991.
authors.forename: L V
authors.initials: LV
authors.lastname: Sherstneva
mesh_terms: D000328:Adult; D000368:Aged; D003315:Cornea / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D019468:Disease Management; D042241:Early Diagnosis; D005128:Eye Diseases / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013508:Ophthalmologic Surgical Procedures / Q000379:methods*; D020551:Pulse Therapy, Drug; D011878:Radiotherapy / Q000379:methods*; D012720:Severity of Illness Index; D013959:Thyroid Diseases / Q000150:complications*; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids