title: Profluorescent PPV-Based Micellar System as a Versatile Probe for Bioimaging and Drug Delivery.
abstract: Although micelles are commonly used for drug delivery purposes, their long-term fate is often unknown due to photobleaching of the fluorescent labels or the use of toxic materials. Here, we present a metal-free, nontoxic, nonbleaching, fluorescent micelle that can address these shortcomings. A simple, yet versatile, profluorescent micellar system, built from amphiphilic poly(p-phenylenevinylene) (PPV) block copolymers, for use in drug delivery applications is introduced. Polymer micelles made from PPV show excellent stability for up to 1 year and are successfully loaded with anticancer drugs (curcumin or doxorubicin) without requiring introduction of physical or chemical cross-links. The micelles are taken up efficiently by the cells, which triggers disassembly, releasing the encapsulated material. Disassembly of the micelles and drug release is conveniently monitored as fluorescence of the single polymer chains appear, which enables not only to monitor the release of the payload, but in principle also the fate of the polymer over longer periods of time.
authors.affiliation: Institute for Materials Research, Hasselt University , Martelarenlaan 42, 3500 Hasselt, Belgium.
authors.forename: Neomy
authors.initials: N
authors.lastname: Zaquen
authors.affiliation: Center for Advanced Macromolecular Design (CAMD), School of Chemistry, University of New South Wales , Sydney, NSW 2052, Australia.
authors.forename: Hongxu
authors.initials: H
authors.lastname: Lu
authors.affiliation: Center for Advanced Macromolecular Design (CAMD), School of Chemistry, University of New South Wales , Sydney, NSW 2052, Australia.
authors.forename: Teddy
authors.initials: T
authors.lastname: Chang
authors.affiliation: Center for Advanced Macromolecular Design (CAMD), School of Chemistry, University of New South Wales , Sydney, NSW 2052, Australia.
authors.forename: Russel
authors.initials: R
authors.lastname: Mamdooh
authors.affiliation: Imec Associated Lab IMOMEC, Wetenschapspark 1, 3590 Diepenbeek, Belgium.
authors.forename: Laurence
authors.initials: L
authors.lastname: Lutsen
authors.affiliation: Institute for Materials Research, Hasselt University , Martelarenlaan 42, 3500 Hasselt, Belgium.|Imec Associated Lab IMOMEC, Wetenschapspark 1, 3590 Diepenbeek, Belgium.
authors.forename: Dirk
authors.initials: D
authors.lastname: Vanderzande
authors.affiliation: Center for Advanced Macromolecular Design (CAMD), School of Chemistry, University of New South Wales , Sydney, NSW 2052, Australia.
authors.forename: Martina
authors.initials: M
authors.lastname: Stenzel
authors.affiliation: Institute for Materials Research, Hasselt University , Martelarenlaan 42, 3500 Hasselt, Belgium.|Imec Associated Lab IMOMEC, Wetenschapspark 1, 3590 Diepenbeek, Belgium.
authors.forename: Tanja
authors.initials: T
authors.lastname: Junkers
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D003474:Curcumin / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D008823:Micelles; D057054:Molecular Imaging / Q000379:methods; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D011108:Polymers / Q000737:chemistry*; D011145:Polyvinyls / Q000737:chemistry*; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D005456:Fluorescent Dyes; D008823:Micelles; D011108:Polymers; D011145:Polyvinyls; C470024:poly(4-phenylenevinylene); D004317:Doxorubicin; D003474:Curcumin