title: Clinical Scenario of the Metabolic Syndrome.
abstract: The term metabolic syndrome (MeS) refers to a cluster of associated symptoms composed of impaired fasting glucose, abdominal obesity, hypertension, and dyslipidemia. MeS is associated with an increased risk of cardiovascular and diabetes-associated morbidity and mortality. The increased amount of visceral fat together with a chronic inflammatory state predisposes to the development of arteriosclerosis. Furthermore, insulin resistance (IR) and dyslipidemia are associated with fatty liver disease. In addition, MeS is linked to non-cardiovascular diseases such as cancer as well as psychiatric or endocrine disorders. Here, we discuss the clinical impact of MeS in cardiovascular and non-cardiovascular diseases to highlight the importance of prevention, early diagnosis, and multifactorial treatment of high-risk individuals.
authors.affiliation: Department of Medicine I, University of Lübeck, Lübeck, Germany.
authors.forename: Swantje
authors.initials: S
authors.lastname: Brede
authors.affiliation: Department of Medicine I, University of Lübeck, Lübeck, Germany.
authors.forename: Georg
authors.initials: G
authors.lastname: Serfling
authors.affiliation: Department of Medicine I, University of Lübeck, Lübeck, Germany.
authors.forename: Johanna
authors.initials: J
authors.lastname: Klement
authors.affiliation: Department of Medicine I, University of Lübeck, Lübeck, Germany.
authors.forename: Sebastian M
authors.initials: SM
authors.lastname: Schmid
authors.affiliation: Department of Medicine I, University of Lübeck, Lübeck, Germany.
authors.forename: Hendrik
authors.initials: H
authors.lastname: Lehnert
keywords: Abdominal obesity; Cardiovascular disease; Hyperlipidemia; Insulin resistance; Metabolic syndrome