title: Prostate-specific antigen rising in Iranian men in correlation with body mass index, fasting blood sugar and blood lipid profile.
abstract: BACKGROUND
  Prostate-specific antigen (PSA) is a serine protease that is secreted by prostate cells and it is useful as a tumor marker for prostate cancer.
  
  
  OBJECTIVE
  In this study, the relationship between some of metabolic factors and serum PSA level was investigated.
  
  
  METHODS
  In this cross-sectional study, patients with urinary symptoms or for screening of the prostate cancer (after 50 years of age or 40 years with a family history of prostate cancer), were evaluated. Collected data included metabolic syndrome factors such as cholesterol (Chol), triglycerides (TG), fasting blood sugar (FBS), and body mass index (BMI), serum PSA level, prostate volume and age.
  
  
  RESULTS
  481 patients were enrolled to this study with the average age of 60.69 ± 9.72 years and the average PSA level of 1.70 ng/ml. Data analysis showed that there was a significant relationship between serum PSA level with age (P< 0.001, r = 0.30) and prostate volume (P< 0.001, r = 0.29). There were not significant relationship between serum PSA level with TG (P= 0.57, r = 0.026), Chol (P= 0.57, r = -0.025), FBS (P= 0.054, r = 0.088), and BMI (P= 0.89, r = 0.006).
  
  
  CONCLUSIONS
  This study showed that, with increasing age and prostate volume, serum PSA level increased, and an increase in the levels of cholesterol, TG, FBS and BMI did not have significant effect on serum PSA level.
authors.affiliation: Department of Surgery, Clinical Research Development Center, Semnan University of Medical Sciences, Semnan, Iran.
authors.forename: Davood
authors.initials: D
authors.lastname: Arab
authors.affiliation: Department of Surgery, Clinical Research Development Center, Semnan University of Medical Sciences, Semnan, Iran.
authors.forename: Arash
authors.initials: A
authors.lastname: Ardestani Zadeh
authors.affiliation: Social Determinants of Health Research Center, Kowsar Hospital, Semnan University of Medical Sciences, Semnan, Iran.
authors.forename: Majid
authors.initials: M
authors.lastname: Mirmohammadkhani
authors.affiliation: Department of Surgery, Clinical Research Development Center, Semnan University of Medical Sciences, Semnan, Iran.
authors.forename: Azadeh
authors.initials: A
authors.lastname: Beiglarzadeh
keywords: Body mass index; Cholesterol; Fasting blood sugar; Prostate-specific antigen; Triglycerides