title: Axiographic results of CAD/CAM-assisted microvascular, fibular free flap reconstruction of the mandible: A prospective study of 21 consecutive cases.
abstract: Virtual planning and guided reconstruction of the mandible following ablative surgery have become standard procedures in reconstructive surgery. Many advantages regarding operation time, morphology, bony fit, and consolidation have been described, but analyses of the functional outcome of virtually planned mandibular reconstructions are lacking. We prospectively analyzed 21 consecutive cases of mandibular reconstructions using CAD/CAM-assisted microvascular, fibular free flaps in operations between July 2014 and January 2016 at a single center. Axiographic measurements were performed preoperatively and at 10 days and 3 months postoperatively and were correlated with clinical findings. Uni- and multivariate regression analyses were performed to determine the association between possible predictor variables on functional outcomes. Overall, no statistical differences between the t1 and t3 measurements were seen in the analyzed variables. The univariate analysis showed a significant influence of indication and pre- and postoperative irradiation only on mouth opening (p = 0.018, p = 0.026, and p = 0.049). Timing, the number of osteotomies, and the incidence of wound healing disturbances had no significant influence on postoperative function (p = 0.753, p = 0.69 and p = 0.776). In particular, cases without malignancy or preoperative irradiation benefitted from the integration of the CAD/CAM technique and showed good functional outcomes.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Klinikum rechts der Isar, Technische Universität München, Germany. Electronic address: Lucas.Ritschl@tum.de.
authors.forename: Lucas M
authors.initials: LM
authors.lastname: Ritschl
authors.affiliation: Department of Oral and Maxillofacial Surgery, Klinikum rechts der Isar, Technische Universität München, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Mücke
authors.affiliation: Department of Oral and Maxillofacial Surgery, Klinikum rechts der Isar, Technische Universität München, Germany.
authors.forename: Andreas M
authors.initials: AM
authors.lastname: Fichter
authors.affiliation: Department of Oral and Maxillofacial Surgery, Klinikum rechts der Isar, Technische Universität München, Germany.
authors.forename: Maximilian
authors.initials: M
authors.lastname: Roth
authors.affiliation: Department of Oral and Maxillofacial Surgery, Klinikum rechts der Isar, Technische Universität München, Germany.
authors.forename: Clemens
authors.initials: C
authors.lastname: Kaltenhauser
authors.affiliation: Department of Prosthodontics, Dental School of the Ludwig-Maximilians University of Munich, Germany.
authors.forename: Jean Marc
authors.initials: JM
authors.lastname: Pho Duc
authors.affiliation: Department of Oral and Maxillofacial Surgery, Klinikum rechts der Isar, Technische Universität München, Germany.
authors.forename: Marco R
authors.initials: MR
authors.lastname: Kesting
authors.affiliation: Department of Oral and Maxillofacial Surgery, Klinikum rechts der Isar, Technische Universität München, Germany.
authors.forename: Klaus-Dietrich
authors.initials: KD
authors.lastname: Wolff
authors.affiliation: Department of Oral and Maxillofacial Surgery, Klinikum rechts der Isar, Technische Universität München, Germany.
authors.forename: Denys J
authors.initials: DJ
authors.lastname: Loeffelbein
mesh_terms: D000086:Acetazolamide; D017076:Computer-Aided Design; D005260:Female; D005360:Fibula / Q000637:transplantation*; D058752:Free Tissue Flaps / Q000601:surgery*; D006801:Humans; D008297:Male; D063175:Mandibular Reconstruction / Q000379:methods*; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D000086:Acetazolamide
keywords: Axiography; CAD/CAM; Fibula free flap; Functional analysis; Mandibular reconstruction