title: Association of body mass index-related single nucleotide polymorphisms with psychiatric disease and memory performance in a Japanese population.
abstract: OBJECTIVE
  Obesity is a risk factor for psychiatric diseases. Recently, a number of single nucleotide polymorphisms (SNPs) have been shown to be related to body mass index (BMI). In this study, we investigated the association of BMI-related SNPs with psychiatric diseases and one of their endophenotypes, memory performance, in a Japanese population.
  
  
  METHODS
  The subjects were 1624 patients with one of three psychiatric diseases (799 patients with major depressive disorder, 594 with schizophrenia, and 231 with bipolar disorder) and 1189 healthy controls. Memory performance was assessed using the Wechsler Memory Scale - Revised (WMS-R). Genomic DNA was prepared from venous blood and used to genotype 23 BMI-related SNPs using the TaqMan 5'-exonuclease allelic discrimination assay. We then analysed the relationships between the SNPs and psychiatric disease and various subscales of the WMS-R.
  
  
  RESULTS
  Three SNPs (rs11142387, rs12597579, and rs6548238) showed significant differences in the genotype or allele frequency between patients with any psychiatric diseases and controls. Furthermore, six SNPs (rs11142387, rs12597579, rs2815752, rs2074356, rs4776970, and rs2287019) showed significant differences in at least one subscale of the WMS-R depending on the genotypes of the healthy controls. Interestingly, rs11142387 near the Kruppel-like factor 9 (KLF9) was significantly associated with psychiatric disease and poor memory function.
  
  
  CONCLUSIONS
  We identified three and six BMI-related SNPs associated with psychiatric disease and memory performance, respectively. In particular, carrying the A allele of rs11142387 near KLF9 was found to be associated with psychiatric disease and poor memory performance, which warrants further investigations.
authors.affiliation: 1Department of Mental Disorder Research,National Center of Neurology and Psychiatry,National Institute of Neuroscience,Tokyo,Japan.
authors.forename: Midori
authors.initials: M
authors.lastname: Ninomiya-Baba
authors.affiliation: 1Department of Mental Disorder Research,National Center of Neurology and Psychiatry,National Institute of Neuroscience,Tokyo,Japan.
authors.forename: Junko
authors.initials: J
authors.lastname: Matsuo
authors.affiliation: 1Department of Mental Disorder Research,National Center of Neurology and Psychiatry,National Institute of Neuroscience,Tokyo,Japan.
authors.forename: Daimei
authors.initials: D
authors.lastname: Sasayama
authors.affiliation: 1Department of Mental Disorder Research,National Center of Neurology and Psychiatry,National Institute of Neuroscience,Tokyo,Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Hori
authors.affiliation: 1Department of Mental Disorder Research,National Center of Neurology and Psychiatry,National Institute of Neuroscience,Tokyo,Japan.
authors.forename: Toshiya
authors.initials: T
authors.lastname: Teraishi
authors.affiliation: 1Department of Mental Disorder Research,National Center of Neurology and Psychiatry,National Institute of Neuroscience,Tokyo,Japan.
authors.forename: Miho
authors.initials: M
authors.lastname: Ota
authors.affiliation: 1Department of Mental Disorder Research,National Center of Neurology and Psychiatry,National Institute of Neuroscience,Tokyo,Japan.
authors.forename: Kotaro
authors.initials: K
authors.lastname: Hattori
authors.affiliation: 4Department of Psychiatry,National Center of Neurology and Psychiatry Hospital,Tokyo,Japan.
authors.forename: Takamasa
authors.initials: T
authors.lastname: Noda
authors.affiliation: 1Department of Mental Disorder Research,National Center of Neurology and Psychiatry,National Institute of Neuroscience,Tokyo,Japan.
authors.forename: Ikki
authors.initials: I
authors.lastname: Ishida
authors.affiliation: 2Laboratory of Physiology and Pharmacology,School of Advanced Science and Engineering,Waseda University,Tokyo,Japan.
authors.forename: Shigenobu
authors.initials: S
authors.lastname: Shibata
authors.affiliation: 1Department of Mental Disorder Research,National Center of Neurology and Psychiatry,National Institute of Neuroscience,Tokyo,Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kunugi
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D001714:Bipolar Disorder / Q000150:complications / Q000235:genetics; D015992:Body Mass Index; D003865:Major Depressive Disorder / Q000150:complications / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007564:Japan; D008297:Male; D008568:Memory; D001523:Mental Disorders / Q000150:complications* / Q000235:genetics*; D008875:Middle Aged; D009483:Neuropsychological Tests; D009765:Obesity / Q000150:complications* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000150:complications / Q000235:genetics
keywords: BMI; SNP; Wechsler Memory Scale – Revised; memory; psychiatric disorders