title: Microorganisms isolated from cultures and infection focus and antibiotic treatments in febrile neutropenic children from Şanlıurfa, Turkey.
abstract: Chemotherapy induced febrile neutropenia predisposes patients to life threatening infections. We aimed to determine the causative microorganisms, infection focus and antibiotic treatment success in febrile neutropenic children with leukemia. A total of 136 febrile neutropenic episodes in 48 leukemic children were reviewed retrospectively from records. Among 136 febrile neutropenic episodes, 68 (50%) episodes were microbiologically documented. Methicillin sensitive coagulase (-) Staphylococcus aureus were the most common isolates from hemoculture (20.5%). The most frequently documented infection focus was mucositis (31.9%). Ceftazidime plus amikacin was the most commonly used antimicrobial treatment for the empirical therapy (52.9%). The overall response rates were 70.5%, 86.9%, and 66.6% of first line, second line and third line therapies, respectively. The spectrum of isolates among febrile neutropenic children in our hematology clinic appears to be gram positive pathogens which are the most common agents. Therefore the, documentation of the flora in each unit could help to decide appropriate empirical therapy which is life saving.
authors.affiliation: Division of Pediatric Hematology, Department of Pediatrics Harran University Faculty of Medicine, Şanlıurfa, Turkey.
authors.forename: Z Canan
authors.initials: ZC
authors.lastname: Özdemir
authors.affiliation: Division of Pediatric Hematology/Oncology, Department of Pediatrics, Marmara University Faculty of Medicine, İstanbul, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Koç
authors.affiliation: Eskişehir State Hospital, Eskişehir, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Ayçiçek
mesh_terms: D000293:Adolescent; D000583:Amikacin / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001419:Bacteria / Q000302:isolation & purification*; D002442:Ceftazidime / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D064147:Febrile Neutropenia / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*; D005260:Female; D006801:Humans; D007223:Infant; D007938:Leukemia / Q000150:complications; D008297:Male; D012189:Retrospective Studies; D016896:Treatment Outcome; D014421:Turkey / Q000453:epidemiology
chemical_list: D000900:Anti-Bacterial Agents; D000583:Amikacin; D002442:Ceftazidime
keywords: child; empiric therapy; fever; leukemia; neutropenia