title: Hypolipidemic Effect of the Autoclaved Extract Prepared from Pea (Pisum sativum L.) Pods In Vivo and In Vitro.
abstract: By autoclaving, we obtained a polyphenol and dietary fiber from pea (Pisum sativum L.) pods in parallel without acid or alkali treatment or organic solvent extraction. Rats fed a high-sucrose (HS) diet containing 3% autoclaved extract (AE) for 4 wk exhibited significantly lower serum triglyceride and total cholesterol levels than rats fed a HS diet. AE and soluble dietary fiber (SDF) from AE exhibited pancreatic lipase inhibitory activity at 13.3 mg/mL in vitro. AE and insoluble dietary fiber (IDF) from AE adsorbed cholesterol. In total, 30% and 10% of a cholesterol micelle were significantly adsorbed by 2,000 mg of AE and 100 mg of IDF from AE in 7 mL, respectively. The amount of bifidobacteria in the cecum of the AE group was significantly increased compared with that in the HS group. These results suggest that AE has hypolipidemic, bifidogenic potential.
authors.affiliation: Faculty of Home Economics, Kobe Women's University.
authors.forename: Kae
authors.initials: K
authors.lastname: Inagaki
authors.forename: Yuuki
authors.initials: Y
authors.lastname: Nishimura
authors.forename: Emiko
authors.initials: E
authors.lastname: Iwata
authors.forename: Sachinobu
authors.initials: S
authors.lastname: Manabe
authors.forename: Masahiro
authors.initials: M
authors.lastname: Goto
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Ogura
authors.forename: Hisako
authors.initials: H
authors.lastname: Hotta
mesh_terms: D000818:Animals; D001644:Bifidobacterium; D001647:Bile Acids and Salts / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism; D002432:Cecum / Q000187:drug effects / Q000382:microbiology; D002784:Cholesterol / Q000097:blood; D004043:Dietary Fiber / Q000032:analysis / Q000494:pharmacology*; D005243:Feces / Q000737:chemistry; D000069196:Gastrointestinal Microbiome / Q000187:drug effects; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008049:Lipase / Q000037:antagonists & inhibitors / Q000378:metabolism; D008297:Male; D010179:Pancreas / Q000187:drug effects / Q000201:enzymology; D018532:Pisum sativum / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014280:Triglycerides / Q000097:blood
chemical_list: D001647:Bile Acids and Salts; D001786:Blood Glucose; D004043:Dietary Fiber; D000960:Hypolipidemic Agents; D010936:Plant Extracts; D014280:Triglycerides; D002784:Cholesterol; D008049:Lipase