title: Protective effects of dietary selenium and vitamin C in barium-induced cardiotoxicity.
abstract: Several metals including barium (Ba) known as environmental pollutants provoke deleterious effects on human health. The present work pertains to the potential ability of selenium (Se) and/or vitamin C, used as nutritional supplements, to alleviate the toxic effects induced by barium chloride (BaCl2) in the heart of adult rats. Animals were randomly divided into seven groups of six each: group 1, serving as negative controls, received distilled water; group 2 received in their drinking water BaCl2(67 ppm); group 3 received both Ba and Se (sodium selenite 0.5 mg kg-1of diet); group 4 received both Ba and vitamin C (200 mg kg-1bodyweight) via force feeding; group 5 received Ba, Se, and vitamin C; and groups 6 and 7, serving as positive controls, received either Se or vitamin C for 21 days. The exposure of rats to BaCl2caused cardiotoxicity as monitored by an increase in malondialdehyde, hydrogen peroxide, and advanced oxidation protein product levels, a decrease in Na+-K+adenosine triphosphatase (ATPase), Mg2+ATPase, and acetylcholinesterase activities and in antioxidant defense system (catalase, glutathione peroxidase, superoxide dismutase, glutathione, and nonprotein thiols). Plasma lactate dehydrogenase and creatine kinase activities, total cholesterol, triglyceride, and low-density lipoprotein-cholesterol levels increased, while high-density lipoprotein-cholesterol level decreased. Coadministration of Se and/or vitamin C restored the parameters indicated above to near control values. The histopathological findings confirmed the biochemical results. Se and vitamin C may be a promising therapeutic strategy for Ba-induced heart injury.
authors.affiliation: 1 Animal Physiology Laboratory, Faculty of Sciences, Sfax University, Sfax, Tunisia.
authors.forename: Awatef
authors.initials: A
authors.lastname: Elwej
authors.affiliation: 1 Animal Physiology Laboratory, Faculty of Sciences, Sfax University, Sfax, Tunisia.
authors.forename: Imen
authors.initials: I
authors.lastname: Ghorbel
authors.affiliation: 1 Animal Physiology Laboratory, Faculty of Sciences, Sfax University, Sfax, Tunisia.
authors.forename: Mariem
authors.initials: M
authors.lastname: Chaabane
authors.affiliation: 1 Animal Physiology Laboratory, Faculty of Sciences, Sfax University, Sfax, Tunisia.
authors.forename: Nejla
authors.initials: N
authors.lastname: Soudani
authors.affiliation: 2 Biochemistry Laboratory, CHU Hedi Chaker, University of Sfax, Sfax, Tunisia.
authors.forename: Rim
authors.initials: R
authors.lastname: Marrekchi
authors.affiliation: 2 Biochemistry Laboratory, CHU Hedi Chaker, University of Sfax, Sfax, Tunisia.
authors.forename: Kamel
authors.initials: K
authors.lastname: Jamoussi
authors.affiliation: 3 Anatomopathology Laboratory, CHU Habib Bourguiba, Sfax University, Sfax, Tunisia.
authors.forename: Hela
authors.initials: H
authors.lastname: Mnif
authors.affiliation: 3 Anatomopathology Laboratory, CHU Habib Bourguiba, Sfax University, Sfax, Tunisia.
authors.forename: Tahia
authors.initials: T
authors.lastname: Boudawara
authors.affiliation: 1 Animal Physiology Laboratory, Faculty of Sciences, Sfax University, Sfax, Tunisia.
authors.forename: Najiba
authors.initials: N
authors.lastname: Zeghal
authors.affiliation: 1 Animal Physiology Laboratory, Faculty of Sciences, Sfax University, Sfax, Tunisia.
authors.forename: Mediha
authors.initials: M
authors.lastname: Sefi
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D017609:Barium Compounds / Q000633:toxicity*; D002712:Chlorides / Q000633:toxicity*; D004032:Diet; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D006321:Heart / Q000187:drug effects; D006331:Heart Diseases / Q000139:chemically induced* / Q000188:drug therapy; D006861:Hydrogen Peroxide; D015227:Lipid Peroxidation; D009206:Myocardium / Q000201:enzymology / Q000473:pathology; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012643:Selenium / Q000008:administration & dosage / Q000494:pharmacology*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
chemical_list: D017609:Barium Compounds; D002712:Chlorides; C024986:barium chloride; D006861:Hydrogen Peroxide; D000110:Acetylcholinesterase; D000251:Adenosine Triphosphatases; C035123:magnesium sodium ATPase; D000254:Sodium-Potassium-Exchanging ATPase; D012643:Selenium; D001205:Ascorbic Acid
keywords: AChE; Barium chloride; heart injury; membrane-bound ATPase; rats; selenium; vitamin C