title: Effective Antibiotic Conservation by Emergency Antimicrobial Stewardship During a Drug Shortage.
abstract: We present the first description of an antimicrobial stewardship program (ASP) used to successfully manage a multi-antimicrobial drug shortage. Without resorting to formulary restriction, meropenem utilization decreased by 69% and piperacillin-tazobactam by 73%. During the shortage period, hospital mortality decreased (P=.03), while hospital length of stay remained unchanged. Infect Control Hosp Epidemiol 2017;38:356-359.
authors.affiliation: 1Division of Infectious Diseases,Washington University School of Medicine,St. Louis,Missouri.
authors.forename: Kevin
authors.initials: K
authors.lastname: Hsueh
authors.affiliation: 1Division of Infectious Diseases,Washington University School of Medicine,St. Louis,Missouri.
authors.forename: Maria
authors.initials: M
authors.lastname: Reyes
authors.affiliation: 2Barnes-Jewish Hospital,St. Louis,Missouri.
authors.forename: Tamara
authors.initials: T
authors.lastname: Krekel
authors.affiliation: 2Barnes-Jewish Hospital,St. Louis,Missouri.
authors.forename: Ed
authors.initials: E
authors.lastname: Casabar
authors.affiliation: 2Barnes-Jewish Hospital,St. Louis,Missouri.
authors.forename: David J
authors.initials: DJ
authors.lastname: Ritchie
authors.affiliation: 1Division of Infectious Diseases,Washington University School of Medicine,St. Louis,Missouri.
authors.forename: S Reza
authors.initials: SR
authors.lastname: Jafarzadeh
authors.affiliation: 4Center for Clinical Excellence, BJC Healthcare, St. Louis,Missouri.
authors.forename: Amanda J
authors.initials: AJ
authors.lastname: Hays
authors.affiliation: 1Division of Infectious Diseases,Washington University School of Medicine,St. Louis,Missouri.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Lane
authors.affiliation: 1Division of Infectious Diseases,Washington University School of Medicine,St. Louis,Missouri.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Durkin
mesh_terms: D000046:Academic Medical Centers; D000900:Anti-Bacterial Agents / Q000191:economics* / Q000600:supply & distribution*; D000073602:Antimicrobial Stewardship; D017052:Hospital Mortality / Q000639:trends*; D006801:Humans; D007902:Length of Stay / Q000706:statistics & numerical data*; D016014:Linear Models; D000077731:Meropenem; D008923:Missouri; D010397:Penicillanic Acid / Q000031:analogs & derivatives / Q000600:supply & distribution; D010878:Piperacillin / Q000600:supply & distribution; D000077725:Piperacillin, Tazobactam Drug Combination; D012189:Retrospective Studies; D013845:Thienamycins / Q000600:supply & distribution
chemical_list: D000900:Anti-Bacterial Agents; D013845:Thienamycins; D000077725:Piperacillin, Tazobactam Drug Combination; D010397:Penicillanic Acid; D000077731:Meropenem; D010878:Piperacillin