title: Enhancing Stem Cell Transplantation with "Nutri-technology".
abstract: It is necessary to employ myeloablative irradiation or chemotherapy to deplete the HSC niche to optimize hematopoietic stem cell transplantation. In a recent issue of Science, Taya and colleagues provide evidence for an alternative to the toxic chemoirradiative procedure by showing that a valine-restricted diet is sufficient to empty the bone marrow niche.
authors.affiliation: Longevity Institute, School of Gerontology, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089-0191, USA; Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; IFOM FIRC Institute of Molecular Oncology, Via Adamello 16, Milan, 20139, Italy. Electronic address: vlongo@usc.edu.
authors.forename: Valter D
authors.initials: VD
authors.lastname: Longo
authors.affiliation: IFOM FIRC Institute of Molecular Oncology, Via Adamello 16, Milan, 20139, Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Cortellino
mesh_terms: D001853:Bone Marrow; D016026:Bone Marrow Transplantation; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells; D006801:Humans; D055153:Stem Cell Niche