title: Recent Advances and Future Challenges in Modified Mycotoxin Analysis: Why HRMS Has Become a Key Instrument in Food Contaminant Research.
abstract: Mycotoxins are secondary metabolites produced by pathogenic fungi in crops worldwide. These compounds can undergo modification in plants, leading to the formation of a large number of possible modified forms, whose toxicological relevance and occurrence in food and feed is still largely unexplored. The analysis of modified mycotoxins by liquid chromatography-mass spectrometry remains a challenge because of their chemical diversity, the large number of isomeric forms, and the lack of analytical standards. Here, the potential benefits of high-resolution and ion mobility mass spectrometry as a tool for separation and structure confirmation of modified mycotoxins have been investigated/reviewed.
authors.affiliation: Department of Food Science, University of Parma, Parco Area delle Scienze 95/A, Parma 43124, Italy. laura.righetti1@studenti.unipr.it.
authors.forename: Laura
authors.initials: L
authors.lastname: Righetti
authors.affiliation: Center of Biomedicine, European Academy of Bolzano/Bozen, Via Galvani 31, Bolzano 39100, Italy. beppepaglia@gmail.com.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Paglia
authors.affiliation: Department of Food Science, University of Parma, Parco Area delle Scienze 95/A, Parma 43124, Italy. gianni.galaverna@unipr.it.
authors.forename: Gianni
authors.initials: G
authors.lastname: Galaverna
authors.affiliation: Department of Food Science, University of Parma, Parco Area delle Scienze 95/A, Parma 43124, Italy. chiara.dallasta@unipr.it.
authors.forename: Chiara
authors.initials: C
authors.lastname: Dall'Asta
mesh_terms: D000818:Animals; D002853:Chromatography, Liquid; D005506:Food Contamination / Q000032:analysis; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods; D015394:Molecular Structure; D009183:Mycotoxins / Q000032:analysis* / Q000737:chemistry
chemical_list: D009183:Mycotoxins
keywords: high resolution mass spectrometry; ion mobility spectrometry; modified mycotoxins