title: Multimodal Imaging of Neurometabolic Pathology due to Traumatic Brain Injury.
abstract: The impact of traumatic brain injury (TBI) involves a combination of complex biochemical processes beginning with the initial insult and lasting for days, months and even years post-trauma. These changes range from neuronal integrity losses to neurotransmitter imbalance and metabolite dysregulation, leading to the release of pro- or anti-apoptotic factors which mediate cell survival or death. Such dynamic processes affecting the brain's neurochemistry can be monitored using a variety of neuroimaging techniques, whose combined use can be particularly useful for understanding patient-specific clinical trajectories. Here, we describe how TBI changes the metabolism of essential neurochemical compounds, summarize how neuroimaging approaches facilitate the study of such alterations, and highlight promising ways in which neuroimaging can be used to investigate post-TBI changes in neurometabolism.
authors.affiliation: USC Mark and Mary Stevens Neuroimaging and Informatics Institute, 2025 Zonal Avenue, Keck School of Medicine of USC, University of Southern California, Los Angeles, California 90033, USA. Electronic address: jvanhorn@usc.edu.
authors.forename: John Darrell
authors.initials: JD
authors.lastname: Van Horn
authors.affiliation: USC Mark and Mary Stevens Neuroimaging and Informatics Institute, 2025 Zonal Avenue, Keck School of Medicine of USC, University of Southern California, Los Angeles, California 90033, USA.
authors.forename: Avnish
authors.initials: A
authors.lastname: Bhattrai
authors.affiliation: USC Mark and Mary Stevens Neuroimaging and Informatics Institute, 2025 Zonal Avenue, Keck School of Medicine of USC, University of Southern California, Los Angeles, California 90033, USA.
authors.forename: Andrei
authors.initials: A
authors.lastname: Irimia
mesh_terms: D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology; D000070642:Brain Injuries, Traumatic / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D064847:Multimodal Imaging; D059906:Neuroimaging; D009474:Neurons / Q000378:metabolism / Q000473:pathology
keywords: metabolism; neurochemistry; neuroimaging; pathology; traumatic brain injury (TBI)