title: Fc gamma receptor IIIa polymorphism is not associated with susceptibility to systemic lupus erythematosus in Brazilian patients.
abstract: We evaluated the possible association between FCGR3A V/F (158) polymorphism and SLE susceptibility and clinical phenotype in 305 sequentially retrieved SLE patients and 300 healthy controls from the southeastern part of Brazil by allele-specific polymerase chain reaction. Our results showed no association between FCGR3A 158V/F alleles and susceptibility to SLE in this series of patients albeit the heterozygous genotype was strongly associated with the disease.
authors.affiliation: Universidade Federal de São Paulo (UNIFESP), Departamento de Medicina, Disciplina de Reumatologia, São Paulo, SP, Brazil.
authors.forename: Marcelle
authors.initials: M
authors.lastname: Grecco
authors.affiliation: Universidade Federal de São Paulo (UNIFESP), Departamento de Medicina, Disciplina de Reumatologia, São Paulo, SP, Brazil.
authors.forename: Viviane Cardoso Dos
authors.initials: VC
authors.lastname: Santos
authors.affiliation: Universidade Federal de São Paulo (UNIFESP), Departamento de Medicina, Disciplina de Reumatologia, São Paulo, SP, Brazil.
authors.forename: Kaline Medeiros Costa
authors.initials: KM
authors.lastname: Pereira
authors.affiliation: Universidade Federal de São Paulo (UNIFESP), Departamento de Medicina, Disciplina de Reumatologia, São Paulo, SP, Brazil.
authors.forename: Luís Eduardo Coelho
authors.initials: LE
authors.lastname: Andrade
authors.affiliation: Universidade Federal de São Paulo (UNIFESP), Departamento de Medicina, Disciplina de Reumatologia, São Paulo, SP, Brazil. Electronic address: npsilva@unifesp.br.
authors.forename: Neusa Pereira da
authors.initials: NP
authors.lastname: Silva
mesh_terms: D000483:Alleles; D001938:Brazil; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics* / Q000276:immunology; D011110:Polymorphism, Genetic; D017452:Receptors, IgG / Q000235:genetics*
chemical_list: C496124:FCGR3A protein, human; D017452:Receptors, IgG
keywords: Fc gamma receptor IIIa; Gene polymorphism; Immunogenetics; Imunogenética; Lúpus eritematoso sistêmico; Polimorfismo de nucleotídeo único; Polimorfismo genético; Receptor Fc gama IIIa; Single nucleotide polymorphism; Systemic lupus erythematosus