title: Association of PDCD1 polymorphism to systemic lupus erythematosus and rheumatoid arthritis susceptibility.
abstract: This study aims to analyze the relationship of programmed cell death 1 (PDCD1) gene polymorphism (PD1.3G/A - rs11568821) with features of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) in a Southern Brazilian population.
  
  
  
  Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was performed in 95 SLE and 87 RA patients and 128 control group individuals from Santa Catarina, Southern Brazil. The Hardy-Weinberg equilibrium (HWE) test, and odds ratio (OR) were analyzed, considering CI 95% and p≤0.05.
  
  
  
  The PD1.3A allele frequencies were 0.095 (SLE), 0.115 (RA) and 0.078 (controls). The genotypes of the control group were in HWE, while those of SLE and RA patients were not. However, we found no association between PD1.3 polymorphism and the SLE or RA susceptibility, nor clinical or epidemiological data.
  
  
  
  There was no significant association between PD1.3 polymorphism and SLE or RA susceptibility in this Southern Brazilian population.
authors.affiliation: Universidade Federal de Santa Catarina, Departamento de Biologia Celular, Embriologia e Genética, Florianópolis, SC, Brazil.
authors.forename: Luisa Matos
authors.initials: LM
authors.lastname: do Canto
authors.affiliation: Universidade Federal de Santa Catarina, Departamento de Biologia Celular, Embriologia e Genética, Florianópolis, SC, Brazil.
authors.forename: Ticiana Della Justina
authors.initials: TD
authors.lastname: Farias
authors.affiliation: Universidade Federal de Santa Catarina, Departamento de Biologia Celular, Embriologia e Genética, Florianópolis, SC, Brazil.
authors.forename: Mayara Delagnelo
authors.initials: MD
authors.lastname: Medeiros
authors.affiliation: Universidade Federal de Santa Catarina, Departamento de Biologia Celular, Embriologia e Genética, Florianópolis, SC, Brazil.
authors.forename: Cíntia Callegari
authors.initials: CC
authors.lastname: Coêlho
authors.affiliation: Universidade Federal de Santa Catarina, Departamento de Biologia Celular, Embriologia e Genética, Florianópolis, SC, Brazil.
authors.forename: Aline Fernanda Rodrigues
authors.initials: AF
authors.lastname: Sereia
authors.affiliation: Universidade Federal de Santa Catarina, Departamento de Biologia Celular, Embriologia e Genética, Florianópolis, SC, Brazil.
authors.forename: Lia Kubelka Fernandes
authors.initials: LK
authors.lastname: de Carlos Back
authors.affiliation: Universidade do Estado de São Paulo, Faculdade de Medicina, Serviço de Reumatologia, São Paulo, SP, Brazil.
authors.forename: Filipe Martins
authors.initials: FM
authors.lastname: de Mello
authors.affiliation: Universidade Federal de Santa Catarina, Hospital Universitário, Divisão de Reumatologia, Florianópolis, SC, Brazil.
authors.forename: Adriana Fontes
authors.initials: AF
authors.lastname: Zimmermann
authors.affiliation: Universidade Federal de Santa Catarina, Hospital Universitário, Divisão de Reumatologia, Florianópolis, SC, Brazil.
authors.forename: Ivânio Alves
authors.initials: IA
authors.lastname: Pereira
authors.affiliation: Universidade Federal de Santa Catarina, Departamento de Biologia Celular, Embriologia e Genética, Florianópolis, SC, Brazil. Electronic address: iliadarainha@gmail.com.
authors.forename: Ilíada Rainha
authors.initials: IR
authors.lastname: de Souza
mesh_terms: D051017:Apoptosis Regulatory Proteins / Q000235:genetics*; D001172:Arthritis, Rheumatoid / Q000235:genetics*; D001938:Brazil; D016022:Case-Control Studies; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D061026:Programmed Cell Death 1 Receptor
chemical_list: D051017:Apoptosis Regulatory Proteins; C105992:PDCD1 protein, human; D061026:Programmed Cell Death 1 Receptor
keywords: Artrite reumatoide; Autoimmunity; Autoimunidade; Gene PDCD1; Lúpus eritematoso sistêmico; PD1.3 polymorphism; PDCD1 gene; Polimorfismo PD1.3; Rheumatoid arthritis; Systemic lupus erythematosus