title: Therapeutic role of sirtuins in neurodegenerative disease and their modulation by polyphenols.
abstract: Searching for effective therapeutic agents‏‎ to ‎‏prevent‏ ‏neurodegeneration ‎is a challenging task due ‎to ‎the growing list of neurodegenerative disorders associated with a multitude of inter-related pathways.‎ The induction and inhibition of several different signaling pathways has been shown to slow down and/or attenuate ‎neurodegeneration and decline in cognition and locomotor function. Among these signaling pathways, a new class of enzymes known as sirtuins or silent information regulators of gene transcription has been shown to play important regulatory roles in the ageing process. SIRT1, a nuclear sirtuin, has received ‎particular interest due to its role as a deacetylase for several metabolic and signaling proteins involved in stress response, apoptosis, mitochondrial function, self-renewal, and ‎neuroprotection. ‎A new strategy to treat ‎neurodegenerative diseases is targeted therapy. In ‎this ‎paper, we‎ ‎ reviewed up-to-date findings regarding the targeting of ‎SIRT1 by polyphenolic ‎compounds,‎ ‎as a ‎new ‎‏approach in the search for novel, safe and effective treatments for ‎ ‎neurodegenerative ‎diseases. ‎.
authors.affiliation: National Nutrition and Food Technology Research Institute, Faculty of Nutrition Science and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Marjan
authors.initials: M
authors.lastname: Ajami
authors.affiliation: Physiology Research Center and Department of Physiology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Hamidreza
authors.initials: H
authors.lastname: Pazoki-Toroudi
authors.affiliation: Physiology Research Center and Department of Physiology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Hamed
authors.initials: H
authors.lastname: Amani
authors.affiliation: Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
authors.forename: Seyed Fazel
authors.initials: SF
authors.lastname: Nabavi
authors.affiliation: Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Australia. Electronic address: n.braidy@unsw.edu.au.
authors.forename: Nady
authors.initials: N
authors.lastname: Braidy
authors.affiliation: Institute of Biomembranes and Bioenergetics, National Council of Research, Bari, Italy. Electronic address: r.vacca@ibbe.cnr.it.
authors.forename: Rosa Anna
authors.initials: RA
authors.lastname: Vacca
authors.affiliation: Department of Pharmacognosy, University of Vienna, 1090 Vienna, Austria; Institute of Genetics and Animal Breeding of the Polish Academy of Sciences, 05-552 Jastrzebiec, Poland.
authors.forename: Atanas Georgiev
authors.initials: AG
authors.lastname: Atanasov
authors.affiliation: Department of Pharmaceutical Botany, Iuliu Hațieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
authors.forename: Andrei
authors.initials: A
authors.lastname: Mocan
authors.affiliation: Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. Electronic address: Nabavi208@gmail.com.
authors.forename: Seyed Mohammad
authors.initials: SM
authors.lastname: Nabavi
mesh_terms: D006801:Humans; D008928:Mitochondria; D019636:Neurodegenerative Diseases; D059808:Polyphenols; D015398:Signal Transduction; D037761:Sirtuins
chemical_list: D059808:Polyphenols; D037761:Sirtuins
keywords: Ageing; Neurodegeneration; Polyphenolic; SIRT1‎; Sirtuins