title: Are CRH & NGF as psychoneuroimmune regulators in women with polycystic ovary syndrome?
abstract: OBJECTIVE
  Polycystic ovary syndrome (PCOS) affects quality of life and can worsen anxiety and depression either due to the features of PCOS or due to the diagnosis of a chronic disease. Corticotrophin-releasing hormone (CRH) and nerves growth factor (NGF) are the modulator for the actions of the sympathetic nervous and immune systems.
  
  
  METHODS
  In total, 171 women divided into two groups: study and control groups. Serum CRH, NGF, and interleukins: IL-1α. IL-1β, 17A, and TNFα were determined by ELISA Kits in both groups.
  
  
  RESULTS
  The results showed that IL-1α (p < 0.001) and β (p = 0.017) significantly increased in PCO group. CRH, NGF, and IL-17α in serum of patients with PCO significantly lower than the control group (p < 0.001). The results of this study indicate: (1) destruction of three cytokines pattern, (2) Reduction of CRH, NGF, and IL-17α in serum of PCO patients can be under the direct influence of the sympathetic nervous system (SAS), and (3) reduction of CRH and NGFα can be reason of psych/emotional distress in women with PCOS.
  
  
  CONCLUSIONS
  The results of this study confirm (1) low-grade chronic inflammation in PCOS. This impaired cytokine pattern can play a major role in the immune-pathogenesis of PCOS; (2) hyponeurotrophinemia and reduction of CRH in women with PCOS could reﬂect deficit of neuronal stress-adaptation in these patients.
authors.affiliation: a Reproductive Health Research Center, Tehran University of Medical Sciences , Tehran , Iran and.
authors.forename: F Z
authors.initials: FZ
authors.lastname: Zangeneh
authors.affiliation: b Department of Community Medicine , Medical Faculty, Fasa University of Medical Sciences , Fasa , Iran.
authors.forename: M M
authors.initials: MM
authors.lastname: Naghizadeh
authors.affiliation: a Reproductive Health Research Center, Tehran University of Medical Sciences , Tehran , Iran and.
authors.forename: M
authors.initials: M
authors.lastname: Bagheri
authors.affiliation: a Reproductive Health Research Center, Tehran University of Medical Sciences , Tehran , Iran and.
authors.forename: M
authors.initials: M
authors.lastname: Jafarabadi
mesh_terms: D000328:Adult; D003346:Corticotropin-Releasing Hormone / Q000097:blood* / Q000378:metabolism; D015536:Down-Regulation; D005260:Female; D006801:Humans; D020381:Interleukin-17 / Q000097:blood*; D053582:Interleukin-1alpha / Q000097:blood; D053583:Interleukin-1beta / Q000097:blood; D007492:Iran; D020932:Nerve Growth Factor / Q000097:blood* / Q000378:metabolism; D015213:Neuroimmunomodulation; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000276:immunology / Q000378:metabolism* / Q000523:psychology; D011788:Quality of Life; D015203:Reproducibility of Results; D013315:Stress, Psychological; D013564:Sympathetic Nervous System / Q000276:immunology / Q000378:metabolism*; D015854:Up-Regulation; D055815:Young Adult
chemical_list: C508717:IL17A protein, human; C508584:IL1A protein, human; C508585:IL1B protein, human; D020381:Interleukin-17; D053582:Interleukin-1alpha; D053583:Interleukin-1beta; C502240:NGF protein, human; D003346:Corticotropin-Releasing Hormone; D020932:Nerve Growth Factor
keywords: CRH; NGF; interleukins; polycystic ovary syndrome; sympathetic nervous system; tumor necrosis factor alpha