title: CARD14-Mediated Activation of Paracaspase MALT1 in Keratinocytes: Implications for Psoriasis.
abstract: Mutations in caspase recruitment domain-containing protein 14(CARD14) have been linked to susceptibility to psoriasis. CARD14 is an intracellular scaffold protein that regulates proinflammatory gene expression. Recent studies have offered novel insights into the mechanisms of CARD14-mediated signaling in keratinocytes and the molecular impact of psoriasis-associated CARD14 mutations. CARD14 forms a signaling complex with BCL10 and the paracaspase MALT1, and this process is enhanced upon pathogenic CARD14 mutation, culminating in the activation of MALT1 protease activity and psoriasis-associated gene expression. This review summarizes the current knowledge of CARD14/MALT1-mediated signaling in keratinocytes and its therapeutic implications in psoriasis.
authors.affiliation: Unit of Molecular Signal Transduction in Inflammation, Inflammation Research Center, Ghent University-VIB, Ghent, Belgium; Department for Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
authors.forename: Elien
authors.initials: E
authors.lastname: Van Nuffel
authors.affiliation: Interfaculty Institute for Biochemistry, Eberhard Karls University of Tuebingen, Tuebingen, Germany.
authors.forename: Anja
authors.initials: A
authors.lastname: Schmitt
authors.affiliation: Unit of Molecular Signal Transduction in Inflammation, Inflammation Research Center, Ghent University-VIB, Ghent, Belgium; Department for Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
authors.forename: Inna S
authors.initials: IS
authors.lastname: Afonina
authors.affiliation: Interfaculty Institute for Biochemistry, Eberhard Karls University of Tuebingen, Tuebingen, Germany.
authors.forename: Klaus
authors.initials: K
authors.lastname: Schulze-Osthoff
authors.affiliation: Unit of Molecular Signal Transduction in Inflammation, Inflammation Research Center, Ghent University-VIB, Ghent, Belgium; Department for Biomedical Molecular Biology, Ghent University, Ghent, Belgium. Electronic address: rudi.beyaert@irc.vib-ugent.be.
authors.forename: Rudi
authors.initials: R
authors.lastname: Beyaert
authors.affiliation: Interfaculty Institute for Biochemistry, Eberhard Karls University of Tuebingen, Tuebingen, Germany. Electronic address: Stephan.Hailfinger@uni-tuebingen.de.
authors.forename: Stephan
authors.initials: S
authors.lastname: Hailfinger
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism; D000818:Animals; D000074018:B-Cell CLL-Lymphoma 10 Protein; D053468:CARD Signaling Adaptor Proteins / Q000235:genetics / Q000378:metabolism*; D020169:Caspases / Q000235:genetics / Q000378:metabolism*; D006162:Guanylate Cyclase / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D015603:Keratinocytes / Q000378:metabolism*; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D000074884:Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein; D009154:Mutation; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism*; D011565:Psoriasis / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D000074018:B-Cell CLL-Lymphoma 10 Protein; C118591:BCL10 protein, human; D053468:CARD Signaling Adaptor Proteins; D008565:Membrane Proteins; D009363:Neoplasm Proteins; D020169:Caspases; C400109:MALT1 protein, human; D000074884:Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein; C426243:CARD14 protein, human; D006162:Guanylate Cyclase