title: Functional Diversity of Neurotrophin Actions on the Oculomotor System.
abstract: Neurotrophins play a principal role in neuronal survival and differentiation during development, but also in the maintenance of appropriate adult neuronal circuits and phenotypes. In the oculomotor system, we have demonstrated that neurotrophins are key regulators of developing and adult neuronal properties, but with peculiarities depending on each neurotrophin. For instance, the administration of NGF (nerve growth factor), BDNF (brain-derived neurotrophic factor) or NT-3 (neurotrophin-3) protects neonatal extraocular motoneurons from cell death after axotomy, but only NGF and BDNF prevent the downregulation in ChAT (choline acetyltransferase). In the adult, in vivo recordings of axotomized extraocular motoneurons have demonstrated that the delivery of NGF, BDNF or NT-3 recovers different components of the firing discharge activity of these cells, with some particularities in the case of NGF. All neurotrophins have also synaptotrophic activity, although to different degrees. Accordingly, neurotrophins can restore the axotomy-induced alterations acting selectively on different properties of the motoneuron. In this review, we summarize these evidences and discuss them in the context of other motor systems.
authors.affiliation: Departamento de Fisiología, Facultad de Biología, Universidad de Sevilla, 41012 Sevilla, Spain. bbtmino@us.es.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Benítez-Temiño
authors.affiliation: Departamento de Fisiología, Facultad de Biología, Universidad de Sevilla, 41012 Sevilla, Spain. mayadavis@us.es.
authors.forename: María A
authors.initials: MA
authors.lastname: Davis-López de Carrizosa
authors.affiliation: Departamento de Fisiología, Facultad de Biología, Universidad de Sevilla, 41012 Sevilla, Spain. smorcuende@us.es.
authors.forename: Sara
authors.initials: S
authors.lastname: Morcuende
authors.affiliation: Departamento de Fisiología, Facultad de Biología, Universidad de Sevilla, 41012 Sevilla, Spain. matarredona@us.es.
authors.forename: Esperanza R
authors.initials: ER
authors.lastname: Matarredona
authors.affiliation: Departamento de Fisiología, Facultad de Biología, Universidad de Sevilla, 41012 Sevilla, Spain. rmrcruz@us.es.
authors.forename: Rosa R
authors.initials: RR
authors.lastname: de la Cruz
authors.affiliation: Departamento de Fisiología, Facultad de Biología, Universidad de Sevilla, 41012 Sevilla, Spain. ampastor@us.es.
authors.forename: Angel M
authors.initials: AM
authors.lastname: Pastor
mesh_terms: D000818:Animals; D019771:Axotomy; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism* / Q000494:pharmacology; D016923:Cell Death / Q000187:drug effects; D002795:Choline O-Acetyltransferase / Q000096:biosynthesis / Q000235:genetics; D018507:Gene Expression Regulation, Developmental / Q000187:drug effects; D006801:Humans; D009046:Motor Neurons / Q000187:drug effects / Q000378:metabolism*; D020932:Nerve Growth Factor / Q000378:metabolism* / Q000494:pharmacology; D009414:Nerve Growth Factors / Q000378:metabolism* / Q000494:pharmacology; D020933:Neurotrophin 3
chemical_list: D019208:Brain-Derived Neurotrophic Factor; C000595808:NTF3 protein, human; D009414:Nerve Growth Factors; D020933:Neurotrophin 3; D020932:Nerve Growth Factor; D002795:Choline O-Acetyltransferase
keywords: axotomy; development; nervous system; plasticity; trophic factors