title: Outcomes of chest wall resections in pediatric sarcoma patients.
abstract: OBJECTIVE
  Chest wall tumors in pediatric patients are rare. This study evaluates outcomes in pediatric patients who have undergone chest wall resections secondary to sarcomas.
  
  
  METHODS
  A retrospective review was performed for patients <19years old who underwent chest wall resections for sarcoma 1999-2014 at the University of Texas MD Anderson Cancer Center.
  
  
  RESULTS
  Of 44 patients, Ewing's sarcoma (n=18) and osteosarcoma (n=16) were most common. Other sarcomas included synovial sarcoma, chondrosarcoma, and rhabdomyosarcoma. Gore-Tex® or a Marlex™ mesh and methyl methacrylate sandwich was used in 22 patients, and 9 children did not require reconstruction. Twenty-four (54.5%) patients had normal activity, 3 (6.8%) had occasional discomfort, 2 (4.5%) had pain impairing function, 7 (15.9%) required medication or physical therapy for impairment, and 8 (18.2%) needed additional surgery. Five children (11.4%) developed scoliosis, and all of these patients had posterior rib tumors. Median overall survival for the entire cohort was 41.9±11.82months. Histology (p=0.003), location of tumor on the ribs (p=0.007), and surgical margins (p=0.011) were significantly associated with overall survival. Tumors on the middle and posterior (p=0.003) portions of the ribs had a lower chance of death.
  
  
  CONCLUSIONS
  Scoliosis is more common in posterior rib resections. Histology, location of the tumor, and surgical margins impact survival, but, type of reconstruction does not.
  
  
  METHODS
  III.
  
  
  METHODS
  Treatment Study.
authors.affiliation: MD Anderson Cancer Center, Houston, TX.
authors.forename: Carmen
authors.initials: C
authors.lastname: Lopez
authors.affiliation: MD Anderson Cancer Center, Houston, TX.
authors.forename: Arlene
authors.initials: A
authors.lastname: Correa
authors.affiliation: MD Anderson Cancer Center, Houston, TX.
authors.forename: Ara
authors.initials: A
authors.lastname: Vaporciyan
authors.affiliation: MD Anderson Cancer Center, Houston, TX.
authors.forename: Mary
authors.initials: M
authors.lastname: Austin
authors.affiliation: MD Anderson Cancer Center, Houston, TX.
authors.forename: David
authors.initials: D
authors.lastname: Rice
authors.affiliation: MD Anderson Cancer Center, Houston, TX. Electronic address: ahjordan@mdanderson.org.
authors.forename: Andrea
authors.initials: A
authors.lastname: Hayes-Jordan
mesh_terms: D000293:Adolescent; D001859:Bone Neoplasms / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D002813:Chondrosarcoma / Q000601:surgery; D006801:Humans; D012516:Osteosarcoma / Q000601:surgery; D011138:Polytetrafluoroethylene; D011183:Postoperative Complications; D012189:Retrospective Studies; D012208:Rhabdomyosarcoma / Q000601:surgery; D012272:Ribs / Q000601:surgery; D012509:Sarcoma / Q000601:surgery*; D012512:Sarcoma, Ewing / Q000601:surgery; D013584:Sarcoma, Synovial / Q000601:surgery; D012600:Scoliosis / Q000209:etiology; D013899:Thoracic Neoplasms / Q000601:surgery*; D019616:Thoracic Surgical Procedures / Q000009:adverse effects; D035441:Thoracic Wall / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D011138:Polytetrafluoroethylene
keywords: Osteosarcoma; Reconstruction; Rhabdomyosarcoma; Surgery