title: Boosting weakened synapses to treat Alzheimer's disease.
abstract: This paper highlights a recent report by Roy and colleagues showing that boosting plasticity in synapses activated during initial memory encoding ameliorates memory impairments found in the early stages of the familial version of Alzheimer's disease. Our goal was to describe the main features of the report and evaluate the approach and implications of the work.
authors.affiliation: Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, AB, Canada, T1K 3M4. r.mcdonald@uleth.ca.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: McDonald
authors.affiliation: Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, AB, Canada, T1K 3M4.
authors.forename: Scott H
authors.initials: SH
authors.lastname: Deibel
mesh_terms: D000544:Alzheimer Disease / Q000503:physiopathology / Q000628:therapy*; D000818:Animals; D008568:Memory; D008569:Memory Disorders; D013569:Synapses / Q000502:physiology*
keywords: Alzheimer’s disease; Engram; Genetics; Memory; Plasticity