title: Fourteen Years of Experience of Liver Transplantation for Wilson's Disease; a Report on 107 Cases from Shiraz, Iran.
abstract: OBJECTIVE
  Liver transplantation is a potential cure for liver damage from Wilson's disease but the course of neuropsychiatric manifestations after transplantation remains undetermined.
  
  
  METHODS
  In this study, data on all patients who'd received a liver transplant for Wilson's disease at the Shiraz Organ Transplantation Center between December 2000 and March 2014 were reviewed and compared to data on a control group who'd received a liver transplant over the same period but due to other causes.
  
  
  RESULTS
  Out of 2198 patients who'd received a liver transplant in the period; 107 patients were diagnosed with Wilson's disease (21 with fulminant hepatic failure); age of patient ranged from 5 to 59 years; 56.07% of patients in this series had some type of neuropsychiatric manifestation before transplantation, of which 66.67% showed improvement after the procedure. 18 patients had aggravation of neuropsychiatric symptoms after transplantation. These neuropsychiatric symptoms were mostly for anxiety, tremor and depression but there were four cases of new onset dysarthria, rigidity and ataxia in various combinations. Survival rates of 1-month, 1-year, and 5-years for patients with Wilson's disease were 88%, 86%, 82%, respectively, evaluations were not statistically different from that of the control group.
  
  
  CONCLUSIONS
  Liver transplantation showed good long-term results in patients with Wilson's disease, even in those presenting fulminant hepatic failure. Neuropsychiatric manifestations normally show improvement after transplantation but in some cases new onset of manifestations occurred after successful liver transplantation.
authors.affiliation: Health Policy research center, Shiraz university of Medical Sciences, Shiraz, Islamic Republic of Iran.
authors.forename: Kamran B
authors.initials: KB
authors.lastname: Lankarani
authors.affiliation: Shiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran.
authors.forename: Seyed Ali
authors.initials: SA
authors.lastname: Malek-Hosseini
authors.affiliation: Shiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran.
authors.forename: Saman
authors.initials: S
authors.lastname: Nikeghbalian
authors.affiliation: Pediatric Gastroenterology and Hepatology Department, Shiraz University of Medical Sciences, Shiraz, Islamic republic of Iran.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Dehghani
authors.affiliation: Health Policy research center, Shiraz university of Medical Sciences, Shiraz, Islamic Republic of Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Pourhashemi
authors.affiliation: Shiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran.
authors.forename: Kourosh
authors.initials: K
authors.lastname: Kazemi
authors.affiliation: Shiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran.
authors.forename: Parisa
authors.initials: P
authors.lastname: Janghorban
authors.affiliation: Health Policy research center, Shiraz university of Medical Sciences, Shiraz, Islamic Republic of Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Akbari
authors.affiliation: Health Policy research center, Shiraz university of Medical Sciences, Shiraz, Islamic Republic of Iran.
authors.forename: Sulmaz
authors.initials: S
authors.lastname: Ghahramani
authors.affiliation: Transplant Center, Cleveland Clinic, Cleveland, Ohio, United States of America.
authors.forename: Bijan
authors.initials: B
authors.lastname: Eghtesad
authors.affiliation: Gastroenterohepatology Research Center, Shiraz University of Medical sciences, Shiraz, Islamic Republic of Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Moini
authors.affiliation: Shiraz neurology research center, Shiraz University of Medical sciences, Shiraz, Islamic Republic of Iran.
authors.forename: Abbas
authors.initials: A
authors.lastname: Rahmi Jaberi
authors.affiliation: Shiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Shamsaifar
authors.affiliation: Shiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran.
authors.forename: Siavosh
authors.initials: S
authors.lastname: Gholami
authors.affiliation: Gastroenterohepatology Research Center, Shiraz University of Medical sciences, Shiraz, Islamic Republic of Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Rahmanian
authors.affiliation: Shiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran.
authors.forename: Bita
authors.initials: B
authors.lastname: Geramizadeh
mesh_terms: D006527:Hepatolenticular Degeneration / Q000601:surgery*; D006801:Humans; D007492:Iran; D016031:Liver Transplantation