title: Pharmacological Properties of Biocompounds from Spores of the Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes): A Review.
abstract: Ganoderma lucidum is a well-known representative of mushrooms that have been used in traditional Chinese medicine for centuries. New discoveries related to this medicinal mushroom and its biological properties are frequently reported. However, only recently have scientists started to pay special attention to G. lucidum spores. This is in part because of the recent development of methods for breaking the spore wall and extracting biocompounds from the spore. Although some research groups are working with G. lucidum spores, data in the literature are still limited, and the methods used have not been systematized. This review therefore describes the main advances in techniques for breaking the spore wall and extracting biocompounds from the spore. In addition, the major active components identified and their biological properties, such as neurological activity and antiaging and cell-protective effects, are investigated because these are of importance for potential drug development.
authors.affiliation: Department of Bioprocess Engineering and Biotechnology, Federal University of Parana, Curitiba, Parana, Brazil.
authors.forename: Carlos Ricardo
authors.initials: CR
authors.lastname: Soccol
authors.affiliation: Department of Bioprocess Engineering and Biotechnology, Federal University of Parana, Curitiba, Parana, Brazil.
authors.forename: Lucas Yamasaki
authors.initials: LY
authors.lastname: Bissoqui
authors.affiliation: Department of Bioprocess Engineering and Biotechnology, Federal University of Parana, Curitiba, Parana, Brazil.
authors.forename: Cristine
authors.initials: C
authors.lastname: Rodrigues
authors.affiliation: Hospital de Clinicas, Federal University of Parana, Curitiba, Parana, Brazil.
authors.forename: Rosalia
authors.initials: R
authors.lastname: Rubel
authors.affiliation: Center for the Production of and Research into Immunobiological Products, Parana State Department of Health, Piraquara, PR, Brazil.
authors.forename: Sandra R B R
authors.initials: SR
authors.lastname: Sella
authors.affiliation: Institute of Horticulture, Academy of Agronomy Sciences of Zhejiang, Hangzhou, Zhejiang Province, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Leifa
authors.affiliation: Department of Bioprocess Engineering and Biotechnology, Federal University of Parana, Curitiba, Parana, Brazil.
authors.forename: Luciana Porto
authors.initials: LP
authors.lastname: de Souza Vandenberghe
authors.affiliation: Department of Bioprocess Engineering and Biotechnology, Federal University of Parana, Curitiba, Parana, Brazil.
authors.forename: Vanete Thomaz
authors.initials: VT
authors.lastname: Soccol
mesh_terms: D000375:Aging / Q000187:drug effects*; D002491:Central Nervous System Agents / Q000737:chemistry / Q000494:pharmacology*; D019610:Cytoprotection / Q000187:drug effects*; D006801:Humans; D020940:Reishi / Q000737:chemistry*; D013172:Spores, Fungal / Q000737:chemistry*
chemical_list: D002491:Central Nervous System Agents