title: Effect of Exercise and Antidepressants on Skeletal Outcomes in Adolescent Girls With Anorexia Nervosa.
abstract: OBJECTIVE
  We examined the relationships between malnutrition, lifestyle factors, and bone health in anorexia nervosa (AN) via dual-energy X-ray absorptiometry (DXA) and peripheral quantitative computed tomography (pQCT).
  
  
  METHODS
  Seventy adolescent girls with AN and 132 normal-weighted controls underwent pQCT tibial measures including trabecular volumetric bone mineral density (vBMD), cortical vBMD, and cortical thickness. Participants with AN underwent DXA measures of the axial skeleton. We assessed the association of DXA and pQCT measures with clinical and lifestyle variables.
  
  
  RESULTS
  Body mass index Z-score and ideal body weight percentage were positively correlated with trabecular vBMD, cortical CSA, and section modulus (p < .04). Exercise was associated with all pQCT measures but only with hip BMD by DXA. In AN, the use of antidepressants was associated with lower pQCT measures (p < .03).
  
  
  CONCLUSIONS
  Antidepressants may negatively, and exercise positively, influence BMD in adolescents with eating disorders. These findings offer a provocative look at two longstanding questions.
authors.affiliation: Division of Adolescent Medicine, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts; Division of Gynecology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts. Electronic address: amy.divasta@childrens.harvard.edu.
authors.forename: Amy D
authors.initials: AD
authors.lastname: DiVasta
authors.affiliation: Clinical Research Program, Boston Children's Hospital, Boston, Massachusetts; Division of Endocrinology, Boston Children's Hospital, Boston, Massachusetts.
authors.forename: Henry A
authors.initials: HA
authors.lastname: Feldman
authors.affiliation: Rutgers-Robert Wood Johnson Medical School, New Brunswick, New Jersey.
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: O'Donnell
authors.affiliation: Division of Pediatric Nephrology, Stanford University School of Medicine, Palo Alto, California.
authors.forename: Jin
authors.initials: J
authors.lastname: Long
authors.affiliation: Division of Pediatric Nephrology, Stanford University School of Medicine, Palo Alto, California.
authors.forename: Mary B
authors.initials: MB
authors.lastname: Leonard
authors.affiliation: Division of Adolescent and Transition Medicine, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio.
authors.forename: Catherine M
authors.initials: CM
authors.lastname: Gordon
mesh_terms: D015502:Absorptiometry, Photon; D000293:Adolescent; D000856:Anorexia Nervosa / Q000000981:diagnostic imaging / Q000503:physiopathology*; D000928:Antidepressive Agents / Q000009:adverse effects*; D015519:Bone Density / Q000502:physiology*; D016022:Case-Control Studies; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D013977:Tibia / Q000000981:diagnostic imaging
chemical_list: D000928:Antidepressive Agents
keywords: Anorexia nervosa; Antidepressant; DXA; Exercise; Malnutrition; Peripheral quantitative computed tomography