title: Micropatterned Polymer Nanorod Forests and Their Use for Dual Drug Loading and Regulation of Cell Adhesion.
abstract: This paper describes a simple method for the fabrication of micropatterned polymer nanorod forests by templating against the channels in an anodized aluminum oxide membrane partially masked by gelatin. The nanorod forests easily support bimodal drug loading, with one drug encapsulated in the nanorods and the other physisorbed on their surface. During cell culture, preosteoblasts are predominantly attracted to the nanorod forests and driven to climb up along the nanorods. This type of scaffold integrates both microscale and nanoscale features into a single substrate, holding great potential for applications in cell culture and tissue engineering.
authors.affiliation: The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University , Atlanta, Georgia 30332, United States.
authors.forename: Chunlei
authors.identifier: http://orcid.org/0000-0003-2477-306X
authors.initials: C
authors.lastname: Zhu
authors.affiliation: The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University , Atlanta, Georgia 30332, United States.
authors.forename: Jiajia
authors.initials: J
authors.lastname: Xue
authors.affiliation: The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University , Atlanta, Georgia 30332, United States.
authors.forename: Kyle D
authors.identifier: http://orcid.org/0000-0002-3153-8060
authors.initials: KD
authors.lastname: Gilroy
authors.affiliation: The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University , Atlanta, Georgia 30332, United States.
authors.forename: Da
authors.initials: D
authors.lastname: Huo
authors.affiliation: The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University , Atlanta, Georgia 30332, United States.
authors.forename: Song
authors.initials: S
authors.lastname: Shen
authors.affiliation: The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University , Atlanta, Georgia 30332, United States.|School of Chemistry and Biochemistry, School of Chemical and Biomolecular Engineering, Georgia Institute of Technology , Atlanta, Georgia 30332, United States.
authors.forename: Younan
authors.identifier: http://orcid.org/0000-0003-2431-7048
authors.initials: Y
authors.lastname: Xia
mesh_terms: D016475:3T3 Cells; D000537:Aluminum Oxide / Q000737:chemistry*; D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D016503:Drug Delivery Systems / Q000295:instrumentation / Q000379:methods*; D005780:Gelatin / Q000737:chemistry*; D019344:Lactic Acid / Q000737:chemistry*; D051379:Mice; D043942:Nanotubes / Q000737:chemistry*; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D023822:Tissue Engineering / Q000295:instrumentation / Q000379:methods*
chemical_list: D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D005780:Gelatin; D000537:Aluminum Oxide
keywords: cell adhesion; dual drug loading; micropatterning; nanorod forests; tissue engineering