title: Unconventional Reactivity of (Z)-Enoate Propargylic Alcohols in the Presence of Acids.
abstract: The unconventional reactivity of (Z)-enoate-attached propargylic alcohols in the presence of acids (nucleophilic and non-nucleophilic) was described. This study led to the discovery and development of a new strategy for the collective synthesis of the synthetically useful building blocks α-OMs-, α-OTs-, and α-Cl-enones, as well as 4,5-dioxonoates. The reaction proceeded under very mild conditions and showed a broad substrate scope.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Madras, Chennai, Tamilnadu, 600036, India.
authors.forename: Prabhakararao
authors.initials: P
authors.lastname: Tharra
authors.affiliation: Department of Chemistry, Indian Institute of Technology Madras, Chennai, Tamilnadu, 600036, India.
authors.forename: Beeraiah
authors.initials: B
authors.lastname: Baire
keywords: 1,2-diketones; alpha-haloenones; cascade strategy; propargylic alcohols; rearrangement