title: Association of Plasminogen Activator Inhibitor-1 (PAI-1) Gene Polymorphisms with Osteoporotic Vertebral Compression Fractures (OVCFs) in Postmenopausal Women.
abstract: Osteoporosis and osteoporotic fractures are strongly associated with mortality and morbidity, both in developing and developed countries. Menopause accelerates bone loss due to estrogen deficiency and age-related linear bone loss. We investigated plasminogen activator inhibitor-1 (PAI-1) gene polymorphisms in postmenopausal women with osteoporotic vertebral compression fractures (OVCFs). In this case-control study, 355 postmenopausal women were genotyped for the presence ofPAI-1gene polymorphisms -844A > G, -675 4G > 5G, 43G > A, 9785A > G, and 11053T > G. Genetic polymorphisms ofPAI-1were analyzed by the polymerization chain reaction restriction fragment length polymorphism assay, and their association with disease status and folate and homocysteine levels was determined in 158 OVCF patients and 197 control subjects. ThePAI-1-675 5G5G (adjusted odds ratio (AOR), 3.302;p =0.017) and 43GA + AA (AOR, 2.087;p =0.042) genotype frequencies showed significant association with the increased prevalence of OVCFs in postmenopausal women. In addition, we performed gene-environment interaction studies and demonstrated an association betweenPAI-1gene polymorphisms and OVCF prevalence. Our novel finding is the identification of severalPAI-1genetic variants that increase susceptibility to OVCF. Our findings suggest that polymorphisms inPAI-1may contribute to OVCF, and that they can be developed as biomarkers for evaluating OVCF risk.
authors.affiliation: Department of Biomedical Science, College of Life Science, CHA University, Seongnam 13488, Korea. jokim8505@gamil.com.
authors.forename: Jung Oh
authors.initials: JO
authors.lastname: Kim
authors.affiliation: Department of Orthopedics, CHA Bundang Medical Center, CHA University, Seongnam 13496, Korea. hsoohong@cha.ac.kr.
authors.forename: Soo Hong
authors.initials: SH
authors.lastname: Han
authors.affiliation: Department of Orthopedics, CHA Bundang Medical Center, CHA University, Seongnam 13496, Korea. onho1@medigate.net.
authors.forename: Yeon Ho
authors.initials: YH
authors.lastname: Lee
authors.affiliation: Department of Orthopedics, CHA Bundang Medical Center, CHA University, Seongnam 13496, Korea. zenos@chamc.co.kr.
authors.forename: Tae Keun
authors.initials: TK
authors.lastname: Ahn
authors.affiliation: Department of Neurosurgery, CHA Bundang Medical Center, CHA University, Seongnam 13496, Korea. coolppeng@naver.com.
authors.forename: Jae Joon
authors.initials: JJ
authors.lastname: Lim
authors.affiliation: Department of Neurosurgery, Konkuk University Chungju Hospital, Chungju 27376, Korea. cysns@kku.ac.kr.
authors.forename: Young Sun
authors.initials: YS
authors.lastname: Chung
authors.affiliation: Department of Orthopedics, CHA Bundang Medical Center, CHA University, Seongnam 13496, Korea. shinde@chamc.co.kr.
authors.forename: Dong Eun
authors.initials: DE
authors.lastname: Shin
authors.affiliation: Fertility Center of CHA Gangnam Medical Center, CHA University, Seoul 06135, Korea. wooslee@cha.ac.kr.
authors.forename: Woo Sik
authors.initials: WS
authors.lastname: Lee
authors.affiliation: Department of Neurosurgery, CHA Bundang Medical Center, CHA University, Seongnam 13496, Korea. haninbo@gmail.com.
authors.forename: In Bo
authors.initials: IB
authors.lastname: Han
authors.affiliation: Department of Biomedical Science, College of Life Science, CHA University, Seongnam 13488, Korea. nkkim@cha.ac.kr.
authors.forename: Nam Keun
authors.initials: NK
authors.lastname: Kim
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D050815:Fractures, Compression / Q000235:genetics* / Q000473:pathology; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008875:Middle Aged; D010024:Osteoporosis / Q000235:genetics / Q000473:pathology; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D017698:Postmenopause
chemical_list: D017395:Plasminogen Activator Inhibitor 1
keywords: PAI-1; osteoporosis; osteoporotic vertebral compression fractures; plasminogen activator inhibitor-1; polymorphism