title: Behavioral effects of chronic stress in the Fmr1 mouse model for fragile X syndrome.
abstract: Fragile X Syndrome (FXS) is a pervasive developmental disorder due to a mutation in the FMR1 X-linked gene. Despite its clear genetic cause, the expression of FXS symptoms is known to be modulated by environmental factors, including stress. Furthermore, several studies have shown disturbances in stress regulatory systems in FXS patients and Fmr1 mice. These studies have mostly focused on the hormonal responses to stress, using the acute exposure to a single type of stressor. Hence, little is known about the behavioral effects of stress in FXS, and the importance of the nature of the stressing procedure, especially in the context of a repeated exposure that more closely resembles real life conditions. Here we evaluated the effects of chronic exposure to different types of stress (i.e., either repeated restraint or unpredictable stress) on the behavioral phenotype of adult Fmr1 mice. Our results demonstrated that chronic stress induced deficits in social interaction and working memory only in WT mice and the impact of stress depended on the type of stressors and the specific behavior tested. Our data suggest that the behavioral sensitivity to stress is dramatically reduced in FXS, opening new views on the impact of gene-environment interactions in this pathology.
authors.affiliation: Univ. Bordeaux, INCIA, Bat B2, Allée Geoffroy St. Hilaire, CS 50023, 33615, Pessac Cedex, France; CNRS, INCIA, UMR 5287, Bat B2, Allée Geoffroy St. Hilaire, CS 50023, 33615, Pessac Cedex, France.
authors.forename: Valerie
authors.initials: V
authors.lastname: Lemaire-Mayo
authors.affiliation: Univ. Bordeaux, INCIA, Bat B2, Allée Geoffroy St. Hilaire, CS 50023, 33615, Pessac Cedex, France; CNRS, INCIA, UMR 5287, Bat B2, Allée Geoffroy St. Hilaire, CS 50023, 33615, Pessac Cedex, France.
authors.forename: Enejda
authors.initials: E
authors.lastname: Subashi
authors.affiliation: Univ. Bordeaux, INCIA, Bat B2, Allée Geoffroy St. Hilaire, CS 50023, 33615, Pessac Cedex, France; CNRS, INCIA, UMR 5287, Bat B2, Allée Geoffroy St. Hilaire, CS 50023, 33615, Pessac Cedex, France.
authors.forename: Nadia
authors.initials: N
authors.lastname: Henkous
authors.affiliation: Univ. Bordeaux, INCIA, Bat B2, Allée Geoffroy St. Hilaire, CS 50023, 33615, Pessac Cedex, France; CNRS, INCIA, UMR 5287, Bat B2, Allée Geoffroy St. Hilaire, CS 50023, 33615, Pessac Cedex, France.
authors.forename: Daniel
authors.initials: D
authors.lastname: Beracochea
authors.affiliation: Univ. Bordeaux, INCIA, Bat B2, Allée Geoffroy St. Hilaire, CS 50023, 33615, Pessac Cedex, France; CNRS, INCIA, UMR 5287, Bat B2, Allée Geoffroy St. Hilaire, CS 50023, 33615, Pessac Cedex, France. Electronic address: susanna.pietropaolo@u-bordeaux.fr.
authors.forename: Susanna
authors.initials: S
authors.lastname: Pietropaolo
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001526:Behavioral Symptoms / Q000209:etiology*; D003345:Corticosterone / Q000097:blood; D004195:Disease Models, Animal; D005106:Exploratory Behavior; D051860:Fragile X Messenger Ribonucleoprotein 1 / Q000235:genetics / Q000378:metabolism*; D005600:Fragile X Syndrome / Q000235:genetics* / Q000503:physiopathology*; D008124:Locomotion / Q000187:drug effects; D008297:Male; D018782:Maze Learning / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D012919:Social Behavior; D013315:Stress, Psychological / Q000150:complications / Q000523:psychology*
chemical_list: D003345:Corticosterone; D051860:Fragile X Messenger Ribonucleoprotein 1; C497684:Fmr1 protein, mouse
keywords: Chronic stress; Cognition; Fmr1 mouse; Fragile X Syndrome; Open field; Social behavior