title: Recent Advances in Pancreatic Cancer Surgery of Relevance to the Practicing Pathologist.
abstract: Recent advances in pancreatic surgery have the potential to improve outcomes for patients with pancreatic cancer. We address 3 new, trending topics in pancreatic surgery that are of relevance to the pathologist. First, increasing awareness of the prognostic impact of intraoperatively detected extraregional and regional lymph node metastases and the international consensus definition on lymph node sampling and reporting. Second, neoadjuvant chemotherapy, which is capable of changing 10% to 20% of initially unresectable, to resectable disease. Third, in patients who remain unresectable following neoadjuvant chemotherapy, local ablative therapies may change indications for treatment and improve outcomes.
authors.affiliation: Department of Surgery, Academic Medical Center, Meibergdreef 9, Amsterdam 1105 AZ, The Netherlands.
authors.forename: Lennart B
authors.initials: LB
authors.lastname: van Rijssen
authors.affiliation: Department of Surgery, University Medical Center, Heidelberglaan 100, Utrecht 3584 CX, The Netherlands.
authors.forename: Steffi J E
authors.initials: SJ
authors.lastname: Rombouts
authors.affiliation: Department of Surgery, University Medical Center, Heidelberglaan 100, Utrecht 3584 CX, The Netherlands.
authors.forename: Marieke S
authors.initials: MS
authors.lastname: Walma
authors.affiliation: Department of Surgery, Academic Medical Center, Meibergdreef 9, Amsterdam 1105 AZ, The Netherlands.
authors.forename: Jantien A
authors.initials: JA
authors.lastname: Vogel
authors.affiliation: Department of Surgery, Academic Medical Center, Meibergdreef 9, Amsterdam 1105 AZ, The Netherlands.
authors.forename: Johanna A
authors.initials: JA
authors.lastname: Tol
authors.affiliation: Department of Surgery, University Medical Center, Heidelberglaan 100, Utrecht 3584 CX, The Netherlands.
authors.forename: Isaac Q
authors.initials: IQ
authors.lastname: Molenaar
authors.affiliation: Department of Surgery, Erasmus Medical Center, Gravendijkwal 230, Rotterdam 3015 CE, The Netherlands.
authors.forename: Casper H J
authors.initials: CH
authors.lastname: van Eijck
authors.affiliation: Department of Pathology, Academic Medical Center, Meibergdreef 9, Amsterdam 1105 AZ, The Netherlands.
authors.forename: Joanne
authors.initials: J
authors.lastname: Verheij
authors.affiliation: Department of Pathology, Academic Medical Center, Meibergdreef 9, Amsterdam 1105 AZ, The Netherlands.
authors.forename: Marc J
authors.initials: MJ
authors.lastname: van de Vijver
authors.affiliation: Department of Surgery, Academic Medical Center, Meibergdreef 9, Amsterdam 1105 AZ, The Netherlands.
authors.forename: Olivier R C
authors.initials: OR
authors.lastname: Busch
authors.affiliation: Department of Surgery, Academic Medical Center, Meibergdreef 9, Amsterdam 1105 AZ, The Netherlands. Electronic address: m.g.besselink@amc.uva.nl.
authors.forename: Marc G H
authors.initials: MG
authors.lastname: Besselink
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols; D017115:Catheter Ablation / Q000401:mortality* / Q000639:trends; D003131:Combined Modality Therapy / Q000639:trends; D053672:Electrochemotherapy / Q000379:methods* / Q000639:trends; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis / Q000473:pathology*; D020360:Neoadjuvant Therapy; D010190:Pancreatic Neoplasms / Q000473:pathology / Q000601:surgery*; D010336:Pathology; D015996:Survival Rate
keywords: Lymph node; Neoadjuvant; Pancreas; Pancreatoduodenectomy; Pathology; Radiofrequency ablation; Surgery; Whipple