title: Fatty acid profile in cord blood of neonates born to optimally controlled gestational diabetes mellitus.
abstract: To evaluate the fatty acid profile of cord blood phospholipids (PL), cholesteryl esters (CE), triglycerides (TG) and non-esterified fatty acids (NEFA) in neonates born to mothers with gestational diabetes mellitus (GDM) compared to non-diabetic mothers.
  
  
  
  The offspring of 30 pregnant women (15 non-diabetic controls, 15 with diet- or insulin-controlled GDM) were recruited before delivery. Cord blood was collected. After lipid extraction, PL, CE, TG and NEFA were separated by thin layer chromatography and analysed by gas chromatography.
  
  
  
  In GDM vs. control mothers, maternal glycated haemoglobin (A1C, mean±SD) was not different between groups: 5.3±0.5% vs. 5.3±0.3% (p=0.757), respectively. Cord plasma fatty acids were not different in TG, CE and NEFA between GDM and non-diabetic mothers. However, in PL, levels of palmitate, palmitoleate, oleate, vaccinate and di-homo-gamma-linolenate were significantly lower, with a trend for lower arachidonate (p=0.078), in neonates born to GDM mothers compared to controls.
  
  
  
  In contrast to other studies on cord blood docosahexaenoic acid (DHA) levels in GDM mothers, we did not found lower levels of DHA in cord PL, CE, TG or NEFA in neonates born to GDM compared to non-diabetic mothers.
authors.affiliation: Research Center on Aging, Health and Social Services Centre - University Institute of Geriatrics of Sherbrooke, 1036 Belvédère Sud Sherbrooke, Québec, Canada J1H 4C4; Department of Physiology, Université de Sherbrooke, 3001, 12e avenue Nord Sherbrooke, Québec, Canada J1H 5N4.
authors.forename: Pauline
authors.initials: P
authors.lastname: Léveillé
authors.affiliation: Department of Physiology, Université de Sherbrooke, 3001, 12e avenue Nord Sherbrooke, Québec, Canada J1H 5N4; Department of Medicine, Université de Sherbrooke, 3001, 12e avenue Nord Sherbrooke, Québec, Canada J1H 5N4; Centre de recherche du CHUS, 3001, 12e avenue Nord Sherbrooke, Québec, Canada J1H 5N4.
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Ardilouze
authors.affiliation: Department of Medicine, Université de Sherbrooke, 3001, 12e avenue Nord Sherbrooke, Québec, Canada J1H 5N4; Centre de recherche du CHUS, 3001, 12e avenue Nord Sherbrooke, Québec, Canada J1H 5N4.
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Pasquier
authors.affiliation: Department of Medicine, Université de Sherbrooke, 3001, 12e avenue Nord Sherbrooke, Québec, Canada J1H 5N4.
authors.forename: Charles
authors.initials: C
authors.lastname: Deacon
authors.affiliation: Department of Medicine, Université de Sherbrooke, 3001, 12e avenue Nord Sherbrooke, Québec, Canada J1H 5N4.
authors.forename: Kevin
authors.initials: K
authors.lastname: Whittingstall
authors.affiliation: Research Center on Aging, Health and Social Services Centre - University Institute of Geriatrics of Sherbrooke, 1036 Belvédère Sud Sherbrooke, Québec, Canada J1H 4C4; Department of Medicine, Université de Sherbrooke, 3001, 12e avenue Nord Sherbrooke, Québec, Canada J1H 5N4. Electronic address: Melanie.Plourde2@usherbrooke.ca.
authors.forename: Mélanie
authors.initials: M
authors.lastname: Plourde
mesh_terms: D000328:Adult; D002788:Cholesterol Esters / Q000097:blood; D016640:Diabetes, Gestational / Q000097:blood*; D005227:Fatty Acids / Q000032:analysis*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D007231:Infant, Newborn; D010743:Phospholipids / Q000097:blood; D011247:Pregnancy; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D002788:Cholesterol Esters; D005227:Fatty Acids; D005230:Fatty Acids, Nonesterified; D010743:Phospholipids; D014280:Triglycerides
keywords: Docosahexaenoic acid; Gestational diabetes; Polyunsaturated fatty acids