title: Mitomycin C-treated human-induced pluripotent stem cells as a safe delivery system of gold nanorods for targeted photothermal therapy of gastric cancer.
abstract: Human-induced pluripotent stem cells (iPS) possess an intrinsic tumor tropism ability. However, iPS cells are impeded in clinical applications of tumor therapy due to the formation of teratomas and their survival in normal organs such as the liver, lungs, spleen and kidneys. Mitomycin C (MMC) can overcome this limitation by suppressing iPS proliferation. Herein, we fabricated a safe delivery system of iPS cells treated with MMC loading with gold nanorods (AuNRs) for the targeted photothermal treatment of gastric cancer. Our results showed that the tumor cells were efficiently killed by the heat generated from the gold nanorods, and the iPS cells ultimately died due to the action of MMC seven days after the photothermal treatment. This suggested that pre-treated iPS cells with MMC can be used as a novel and safe approach for targeted tumor therapy. This paves the road for clinical translation in the future.
authors.affiliation: Institute of Nano Biomedicine and Engineering, Shanghai Engineering Research Centre for Intelligent Diagnosis and Treatment Instrument, Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai 200240, P.R. China. dxcui@sjtu.edu.cn.
authors.forename: Meng
authors.initials: M
authors.lastname: Yang
authors.forename: Yanlei
authors.initials: Y
authors.lastname: Liu
authors.forename: Wenxiu
authors.initials: W
authors.lastname: Hou
authors.forename: Xiao
authors.initials: X
authors.lastname: Zhi
authors.forename: Chunlei
authors.initials: C
authors.lastname: Zhang
authors.forename: Xinquan
authors.initials: X
authors.lastname: Jiang
authors.forename: Fei
authors.initials: F
authors.lastname: Pan
authors.forename: Yuming
authors.initials: Y
authors.lastname: Yang
authors.forename: Jian
authors.initials: J
authors.lastname: Ni
authors.forename: Daxiang
authors.initials: D
authors.lastname: Cui
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems; D005260:Female; D006046:Gold; D006358:Hot Temperature; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology*; D008807:Mice, Inbred BALB C; D016685:Mitomycin / Q000494:pharmacology*; D043942:Nanotubes; D009374:Neoplasms, Experimental / Q000628:therapy; D010789:Phototherapy; D013274:Stomach Neoplasms / Q000628:therapy*
chemical_list: D016685:Mitomycin; D006046:Gold