title: What Do Reactive Fragments Actually Do in Cells?
abstract: Covalently binding molecules are frequently regarded as being generally promiscuous. In a recent study, binding selectivities and cellular target proteins of a wide variety of reactive fragments are examined in a proteome-wide context.
authors.affiliation: Helmholtz Zentrum München, Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH, Institute of Medicinal Chemistry, Ingolstädter Landstrasse 1, 85764, Neuherberg, Germany.|Leibniz Universität Hannover, Schneiderberg 1B, 30167, Hannover, Germany.
authors.forename: Oliver
authors.identifier: 0000-0001-9671-278X
authors.initials: O
authors.lastname: Plettenburg
mesh_terms: D002477:Cells / Q000737:chemistry* / Q000378:metabolism; D003545:Cysteine / Q000737:chemistry* / Q000378:metabolism; D005978:Glutathione / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism
chemical_list: D011506:Proteins; D005978:Glutathione; D003545:Cysteine
keywords: covalent fragments; proteomics; target identification