title: Methods of Synthesis, Properties and Biomedical Applications of CuO Nanoparticles.
abstract: This study aims to provide an updated survey of the main synthesis methods of copper oxide (CuO) nanoparticles in order to obtain tailored nanosystems for various biomedical applications. The synthesis approach significantly impacts the properties of such nanoparticles and these properties in turn have a significant impact on their biomedical applications. Although not widely investigated as an efficient drug delivery system, CuO nanoparticles have great biological properties including effective antimicrobial action against a wide range of pathogens and also drug resistant bacteria. These properties have led to the development of various approaches with direct applications to the biomedical field, such as tailored surfaces with antimicrobial effect, wound dressings and modified textiles. It is also believed that these nanosystems could represent efficient alternatives in the development of smart systems utilized both for the detection of pathogens and for the treatment of infections.
authors.affiliation: Department of Biomaterials and Medical Devices, Faculty of Medical Engineering, University Politehnica of Bucharest, Bucharest 060042, Romania. grigore.madalina10@gmail.com.
authors.forename: Madalina Elena
authors.initials: ME
authors.lastname: Grigore
authors.affiliation: Department of Biomaterials and Medical Devices, Faculty of Medical Engineering, University Politehnica of Bucharest, Bucharest 060042, Romania. biscu.ramona@hotmail.com.
authors.forename: Elena Ramona
authors.initials: ER
authors.lastname: Biscu
authors.affiliation: Division of Earth, Environmental and Life Sciences, Research Institute of the University of Bucharest (ICUB), Bucharest 060042, Romania. alina_m_h@yahoo.com.|Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Bucharest 060042, Romania. alina_m_h@yahoo.com.
authors.forename: Alina Maria
authors.initials: AM
authors.lastname: Holban
authors.affiliation: Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia Athens, Athens, GA 30602, USA. mcarges@gmail.com.
authors.forename: Monica Cartelle
authors.initials: MC
authors.lastname: Gestal
authors.affiliation: Division of Earth, Environmental and Life Sciences, Research Institute of the University of Bucharest (ICUB), Bucharest 060042, Romania. grumezescu@yahoo.com.
authors.forename: Alexandru Mihai
authors.initials: AM
authors.lastname: Grumezescu
keywords: CuO; antimicrobial nanoparticles; biomedical nanostructures; synthesis