title: Molecular Genetics of Pancreatic Neoplasms.
abstract: Pancreatic neoplasms have a wide range of histologic types with distinct clinical outcomes. Recent advances in high-throughput sequencing technologies have greatly deepened our understanding of pancreatic neoplasms. Now, the exomes of major histologic types of pancreatic neoplasms have been sequenced, and their genetic landscapes have been revealed. This article reviews the molecular changes underlying pancreatic neoplasms, with a special focus on the genetic changes that characterize the histologic types of pancreatic neoplasms. Emphasis is also made on the molecular features of key genes that have the potential for therapeutic targets.
authors.affiliation: Department of Pathology, Johns Hopkins University, CRB-II 362, 1550 Orleans Street, Baltimore, MD 21231, USA.
authors.forename: Waki
authors.initials: W
authors.lastname: Hosoda
authors.affiliation: Department of Pathology, Johns Hopkins University, CRB-II 345, 1550 Orleans Street, Baltimore, MD 21231, USA. Electronic address: ldelong1@jhmi.edu.
authors.forename: Laura D
authors.initials: LD
authors.lastname: Wood
mesh_terms: D061354:Acinar Cells / Q000378:metabolism / Q000473:pathology; D014408:Biomarkers, Tumor; D018267:Carcinoma, Acinar Cell / Q000235:genetics* / Q000473:pathology; D021441:Carcinoma, Pancreatic Ductal / Q000235:genetics* / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000235:genetics* / Q000473:pathology; D004252:DNA Mutational Analysis; D004273:DNA, Neoplasm; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D020022:Genetic Predisposition to Disease; D006801:Humans; D009857:Oncogenes; D010190:Pancreatic Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm
keywords: Histologic type; Molecular genetics; Mutation; Next-generation sequencing; Pancreatic neoplasms; Whole exome sequencing