title: Immunogenetic Markers Definition in Latvian Patients with Lyme Borreliosis and Lyme Neuroborreliosis.
abstract: The aim of this study was to determine the human leukocyte antigen (HLA)-DRB1 alleles in two groups of patients in Latvia: patients with Lyme borreliosis and patients with Lyme neuroborreliosis. The study included 216 patients with Lyme borreliosis, 29 patients with Lyme neuroborreliosis and 282 control persons. All surveyed persons were residents of Latvia. The HLA-DR genotyping was performed by polymerase chain reaction- sequence specific primer (PCR-SSP). The predisposition to the Lyme borreliosis is associated with the HLA-DRB1*07, -DRB1*17(03), -DRB1*04, -DRB1*15(02) alleles. The allele -DRB1*11(05), -DRB1*14(06) and -DRB1*13(06) were significantly more frequent in controls. In-group with Lyme neuroborreliosis differences were found for the -DRB1*07 and -DRB1*04 alleles, but only HLA-DRB1*07 allele was statistically significant after Bonferroni correction and associated with Lyme neuroborreliosis in Latvian patients.
authors.affiliation: Institute of Food Safety, Animal Health and Environment BIOR, Riga LV-1076, Latvia. Lilija.Kovalcuka@bior.lv.
authors.forename: Lilija
authors.initials: L
authors.lastname: Kovalchuka
authors.affiliation: Institute of Food Safety, Animal Health and Environment BIOR, Riga LV-1076, Latvia. Svetlana.Cvetkova@bior.lv.
authors.forename: Svetlana
authors.initials: S
authors.lastname: Cvetkova
authors.affiliation: Institute of Food Safety, Animal Health and Environment BIOR, Riga LV-1076, Latvia. Julija.Trofimova@bior.lv.
authors.forename: Julija
authors.initials: J
authors.lastname: Trofimova
authors.affiliation: Laboratory of Clinical Immunology and Immunogenetic, Riga Stradiņš University, Riga LV-1067, Latvia. Jelena.Eglite@rsu.lv.
authors.forename: Jelena
authors.initials: J
authors.lastname: Eglite
authors.affiliation: Department of Family Medicine, Riga Stradiņš University, Riga LV-1067, Latvia. Sandra.Gintere@rsu.lv.
authors.forename: Sandra
authors.initials: S
authors.lastname: Gintere
authors.affiliation: Centre for Disease Prevention and Control of Latvia, Riga LV-1005, Latvia. Irina.lucenko@spkc.gov.lv.
authors.forename: Irina
authors.initials: I
authors.lastname: Lucenko
authors.affiliation: Department of Infectious Diseases, Medical University of Silesia, 40-055 Katowice, Poland. bgrzesik@hoga.pl.
authors.forename: Barbara
authors.initials: B
authors.lastname: Oczko-Grzesik
authors.affiliation: Department of Infectology and Dermatology, Riga Stradiņš University, Riga LV-1006, Latvia. Ludmila.Viksna@rsu.lv.
authors.forename: Ludmila
authors.initials: L
authors.lastname: Viksna
authors.affiliation: Institute of Food Safety, Animal Health and Environment BIOR, Riga LV-1076, Latvia. Krumina.Angelika@inbox.lv.|Department of Infectology and Dermatology, Riga Stradiņš University, Riga LV-1006, Latvia. Krumina.Angelika@inbox.lv.
authors.forename: Angelika
authors.initials: A
authors.lastname: Krumina
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D005838:Genotype; D059811:HLA-DRB1 Chains / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D055261:Immunogenetic Phenomena; D015994:Incidence; D007844:Latvia / Q000453:epidemiology; D008193:Lyme Disease / Q000097:blood / Q000453:epidemiology* / Q000382:microbiology; D020852:Lyme Neuroborreliosis / Q000097:blood / Q000453:epidemiology / Q000382:microbiology; D008875:Middle Aged; D055815:Young Adult
chemical_list: D015415:Biomarkers; D059811:HLA-DRB1 Chains
keywords: Borrelia burgdorferi; HLA-DRB1; Lyme borreliosis; Lyme neuroborreliosis; immunogenetic markers