title: Plazomicin Activity against 346 Extended-Spectrum-β-Lactamase/AmpC-Producing Escherichia coli Urinary Isolates in Relation to Aminoglycoside-Modifying Enzymes.
abstract: The activity of plazomicin and clinically relevant aminoglycosides was tested against 346 extended-spectrum-β-lactamase/AmpC-producing Escherichia coli urinary isolates, and the results were correlated with the presence of aminoglycoside-modifying enzymes (AMEs). Data showed that plazomicin was very active against all ESBL/AmpC-producing E. coli urinary isolates. Its activity was not related to the AME genes studied.
authors.affiliation: Servicio de Microbiología, Hospital Clínico San Carlos, Madrid, Spain.
authors.forename: Maria Del Carmen
authors.initials: MD
authors.lastname: López-Diaz
authors.affiliation: Servicio de Microbiología, Hospital Clínico San Carlos, Madrid, Spain eculebras.hcsc@salud.madrid.org.
authors.forename: Esther
authors.initials: E
authors.lastname: Culebras
authors.affiliation: Servicio de Microbiología, Hospital Clínico San Carlos, Madrid, Spain.
authors.forename: Iciar
authors.initials: I
authors.lastname: Rodríguez-Avial
authors.affiliation: Servicio de Microbiología, Hospital Clínico San Carlos, Madrid, Spain.
authors.forename: Esther
authors.initials: E
authors.lastname: Rios
authors.affiliation: Servicio de Microbiología, Hospital Clínico San Carlos, Madrid, Spain.
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Viñuela-Prieto
authors.affiliation: Departamento de Medicina (Microbiología), Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain.
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Picazo
authors.affiliation: Departamento de Medicina (Microbiología), Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Rodríguez-Avial
mesh_terms: D000617:Aminoglycosides / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects* / Q000201:enzymology* / Q000235:genetics; D008826:Microbial Sensitivity Tests; D012853:Sisomicin / Q000031:analogs & derivatives* / Q000494:pharmacology; D014551:Urinary Tract / Q000382:microbiology; D001618:beta-Lactamases / Q000378:metabolism*
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D001618:beta-Lactamases; C550938:plazomicin; D012853:Sisomicin
keywords: AMEs; ESBL; Escherichia coli; aminoglycosides; plazomicin