title: Coexistence of systemic sclerosis and sarcoidosis.
abstract: Coexistence of systemic sclerosis (SSc) and sarcoidosis (SA) is rarely reported; 21 cases only were reported in the English medical literature before 2011. It is suggested that low incidence of overlap syndrome of SSc with SA is resulted from different immune mechanisms involved in pathogenesis of the diseases. In SSc patients, a role of Th2 lymphocytes is suggested while in patients with SA such role is attributed to Th1 lymphocytes. The paper presents a 47-year-old woman suffering from SSc for over 6 years. CT scan of the lungs revealed the nodulus of the right lung and enlarged mediastinal lymphatic nodes. Pathologic evaluation of the nodulus provided basis for diagnosis of sarcoidosis. Diagnosis of SSc was based on clinical and capilaroscopic evaluation as well as detection of anti-topoisomerase I antibodies. In the course of the disease, fibrosis of the lung, pulmonary hypertension and cardiac abnormalities with rhythm disturbances were developed. Treatment included cyclophosphamide, mycophenolate mofetil, sildenafil, losartan. Stabilization of the general state of the patient was achieved.
authors.affiliation: Department of Internal Medicine, Subdivision of Gastrology, Medical Center, Jaworzno, Poland.
authors.forename: Sabina
authors.initials: S
authors.lastname: Godziszewska
authors.affiliation: Department of Internal Medicine and Rheumatology, Medical University of Silesia, Katowice, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Widuchowska
authors.affiliation: Department of Internal Medicine and Rheumatology, Medical University of Silesia, Katowice, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Kopeć-Mędrek
authors.affiliation: Department of Internal Medicine and Rheumatology, Medical University of Silesia, Katowice, Poland, e-mail: ejkucharz@poczta.onet.pl.
authors.forename: Eugeniusz Józef
authors.initials: EJ
authors.lastname: Kucharz
mesh_terms: D000974:Antibodies, Antinuclear / Q000097:blood; D001145:Arrhythmias, Cardiac / Q000188:drug therapy / Q000209:etiology; D003520:Cyclophosphamide / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy / Q000209:etiology; D019808:Losartan / Q000627:therapeutic use; D020678:Microscopic Angioscopy; D008875:Middle Aged; D009173:Mycophenolic Acid / Q000627:therapeutic use; D017565:Sarcoidosis, Pulmonary / Q000150:complications* / Q000188:drug therapy; D012595:Scleroderma, Systemic / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D000068677:Sildenafil Citrate / Q000627:therapeutic use
chemical_list: D000974:Antibodies, Antinuclear; D003520:Cyclophosphamide; D000068677:Sildenafil Citrate; D009173:Mycophenolic Acid; D019808:Losartan
keywords:  pulmonary hypertension;  sarcoidosis; Systemic sclerosis; fibrosis of the lungs