title: Association of Anxiety-Related Polymorphisms with Sports Performance in Chilean Long Distance Triathletes: A Pilot Study.
abstract: Different factors affecting athletic performance are well established: intensity and type of training, anthropometric characteristics as well as an important psychological component. However, the contribution of the genetic background has been less investigated. The aim of the present study was to investigate the influence of polymorphisms within genes associated with stress and anxiety (5HTT,CRH2R,ACE,NK1R,5HT1ARandCRF-BP) on the physical capability and sports performance in triathletes. One hundred and ninety two (192) unrelated Chilean triathletes who participated in the 2014 70.3 Pucón city triathlon were divided into opposite subgroups of sports performance according to their time results. We identified significant associations for five polymorphisms (5HTT5-HTTLPR,ACEI/D,NK1Rrs6715729,5HT1AR-1019C>G andCRF-BPCRF-BPs11) with athletic performance. Our results indicate that these polymorphisms are associated with differential sports performance in Chilean triathletes, establishing an initial background for better understanding the relationship between physical performance, genetics and anxiety disorders.
authors.affiliation: Center of Molecular Biology & Pharmacogenetics, Scientific and Technological Bioresource Nucleus (BIOREN), Universidad de La Frontera, Temuco, Chile; Medicine School, Universidad Mayor, Temuco, Chile.
authors.forename: Jorge A
authors.initials: JA
authors.lastname: Sanhueza
authors.affiliation: Center of Molecular Biology & Pharmacogenetics, Scientific and Technological Bioresource Nucleus (BIOREN), Universidad de La Frontera , Temuco, Chile.
authors.forename: Tomás
authors.initials: T
authors.lastname: Zambrano
authors.affiliation: Medicine School, Universidad Mayor , Temuco, Chile.
authors.forename: Carlos
authors.initials: C
authors.lastname: Bahamondes-Avila
authors.affiliation: Center of Molecular Biology & Pharmacogenetics, Scientific and Technological Bioresource Nucleus (BIOREN), Universidad de La Frontera, Temuco, Chile; Millennium Institute for Research in Depression and Personality (MIDAP), Universidad de La Frontera, Temuco, Chile.
authors.forename: Luis A
authors.initials: LA
authors.lastname: Salazar
keywords: Sports performance; anxiety disorders; genetics; polymorphisms