title: Lifestyle interventions to improve the quality of life of men with prostate cancer: A systematic review of randomized controlled trials.
abstract: Improving quality of life is a key issue for patients with prostate cancer (PCa). Lifestyle interventions could positively impact the quality of life of patients. However, there is no clear-cut understanding of the role of diet, exercise and risky behaviour reduction in improving the quality of life of men with PCa. The aim of this review was to systematically summarize randomized controlled trials on lifestyle in PCa patients with quality of life as main outcome. 17 trials were included. Most of them referred to exercise interventions (71%) and involved men undergoing androgen deprivation therapy (47%). Exercise studies yielded the greater amount of positive results on quality of life outcomes (67%), followed by dietary interventions (50%) and combined lifestyle interventions (33%). In particular, supervised exercise programs with resistance training sessions were the ones producing greater convincing evidence for benefits on quality of life. Further studies with high methodological quality providing adequate information to develop evidence-based, personalized lifestyle interventions that can effectively ameliorate PCa-related quality of life are needed.
authors.affiliation: Prostate Cancer Program, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, 20133 Milan, Italy; Dept. of Psychology, Università Cattolica, Largo Gemelli 1, 20123 Milan, Italy. Electronic address: juliapaola.menichettidelor@istitutotumori.mi.it.
authors.forename: Julia
authors.initials: J
authors.lastname: Menichetti
authors.affiliation: Prostate Cancer Program, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, 20133 Milan, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Villa
authors.affiliation: Prostate Cancer Program, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, 20133 Milan, Italy.
authors.forename: Tiziana
authors.initials: T
authors.lastname: Magnani
authors.affiliation: Dept. of Radiation Oncology 1, Fondazione IRCCS Istituto nazionale dei Tumori, Via Venezian 1, 20133 Milan, Italy.
authors.forename: Barbara
authors.initials: B
authors.lastname: Avuzzi
authors.affiliation: Dept. of Radiation Oncology 1, Fondazione IRCCS Istituto nazionale dei Tumori, Via Venezian 1, 20133 Milan, Italy.
authors.forename: Davide
authors.initials: D
authors.lastname: Bosetti
authors.affiliation: Prostate Cancer Program, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, 20133 Milan, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Marenghi
authors.affiliation: Dept. of Radiation Oncology 1, Fondazione IRCCS Istituto nazionale dei Tumori, Via Venezian 1, 20133 Milan, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Morlino
authors.affiliation: Prostate Cancer Program, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, 20133 Milan, Italy.
authors.forename: Tiziana
authors.initials: T
authors.lastname: Rancati
authors.affiliation: University Hospitals Leuven, Department of Urology, Leuven, Belgium.
authors.forename: Hein
authors.initials: H
authors.lastname: Van Poppel
authors.affiliation: Dept. of Radiation Oncology 1, Fondazione IRCCS Istituto nazionale dei Tumori, Via Venezian 1, 20133 Milan, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Salvioni
authors.affiliation: Prostate Cancer Program, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, 20133 Milan, Italy; Dept. of Radiation Oncology 1, Fondazione IRCCS Istituto nazionale dei Tumori, Via Venezian 1, 20133 Milan, Italy; Department of Oncology and Hemato-Oncology, Università di Milano, Via Festa del Perdono 7, 20122, Milan, Italy.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Valdagni
authors.affiliation: Prostate Cancer Program, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, 20133 Milan, Italy.
authors.forename: Lara
authors.initials: L
authors.lastname: Bellardita
mesh_terms: D004032:Diet; D015444:Exercise; D006801:Humans; D008019:Life Style; D008297:Male; D011471:Prostatic Neoplasms / Q000628:therapy; D011788:Quality of Life; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors
keywords: Dietary intervention; Lifestyle intervention; Physical activity; Prostate cancer; Quality of life; Randomized controlled trial; Systematic review