title: Assessing the risk of clinical and pathologic factors for relapse of borderline ovarian tumours.
abstract: The objective of this study was to identify clinical and pathologic factors that are significant to relapse in borderline ovarian tumours (BOT). All patients with BOTs from 1997 to 2012 in our institute were identified. 115 patients were included in the study. The Cox proportional hazards model was used to identify significant factors. The median age was 42 years (range 14-85 years). The majority of the patients were at FIGO stage I (88.7%), and most of the patients had mucinous histology (66.1%), reflecting the predominant distribution of mucinous BOTs in East Asia. The median follow-up was 3.3 years (range 0-4.1 years). Twelve patients (10.4%) relapsed and two died consequently. Advanced stage, invasive implants and restaging surgery were significant factors of recurrence. Serous tumours had slightly higher risk than mucinous tumours, but the difference was not significant. As the study was performed in an area where mucinous BOTs are predominant, the results may complement current literature on BOT management.
authors.affiliation: a Department of Applied Mathematics , National Sun Yat-sen University , Taiwan , ROC.
authors.forename: Chung
authors.initials: C
authors.lastname: Chang
authors.affiliation: b Multidisciplinary Science Research Center , National Sun Yat-sen University , Taiwan , ROC.
authors.forename: Jiabin
authors.initials: J
authors.lastname: Chen
authors.affiliation: a Department of Applied Mathematics , National Sun Yat-sen University , Taiwan , ROC.
authors.forename: Wei-An
authors.initials: WA
authors.lastname: Chen
authors.affiliation: c Department of Pathology and Laboratory Medicine , Kaohsiung Veterans General Hospital , Kaohsiung , Taiwan , ROC.
authors.forename: Szu-Pei
authors.initials: SP
authors.lastname: Ho
authors.affiliation: d Department of Obstetrics and Gynecology , Kaohsiung Veterans General Hospital , Kaohsiung , Taiwan , ROC.
authors.forename: Wen Shiung
authors.initials: WS
authors.lastname: Liou
authors.affiliation: d Department of Obstetrics and Gynecology , Kaohsiung Veterans General Hospital , Kaohsiung , Taiwan , ROC.|e Department of Biological Sciences , National Sun Yat-sen University , Kaohsiung , Taiwan , ROC.|f Department of Pharmacy and Graduate Institute of Pharmaceutical Technology , Ta-Jen University , Pingtung , Taiwan , ROC.|g Institute of Biomedical Sciences , National Sun Yat-Sen University , Kaohsiung , Taiwan , ROC.
authors.forename: An Jen
authors.initials: AJ
authors.lastname: Chiang
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000473:pathology* / Q000628:therapy; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000077216:Carcinoma, Ovarian Epithelial; D005260:Female; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D009375:Neoplasms, Glandular and Epithelial / Q000473:pathology* / Q000628:therapy; D010051:Ovarian Neoplasms / Q000473:pathology* / Q000628:therapy; D012189:Retrospective Studies; D012306:Risk; D055815:Young Adult
keywords: Borderline ovarian tumour; recurrence; risk factors