title: Nanotechnology, a new paradigm in atherosclerosis treatment.
abstract: Atherosclerosis, a known and prevalent disease, causes progressive deterioration of affected vessels, inducing a blood flow reduction with different complications, and its symptoms usually manifest in advanced stages of the disease. Therefore, the classic therapeutic alternatives are insufficient because the damages are many times irreversible. For this reason, there is a need to implement intelligent forms of drug administration and develop new therapeutic targets that reduce the progression of atherosclerotic lesion. The implementation of new tools for prevention, diagnosis and treatment of this cardiovascular disease is of special interest, focusing our attention on achieving a more effective control of the immune system. Finally, this review highlights the latest knowledge about nanotechnology as a powerful, modern, and promising therapeutic alternative applied to atherosclerotic disease, as well as warning of the potential complications with their use.
authors.affiliation: Instituto de Investigación en Ciencias Químicas, Facultad de Ciencias de la Alimentación, Bioquímicas y Farmacéuticas, Universidad Católica de Cuyo, San Juan, San Juan, Argentina.
authors.forename: Virna M
authors.initials: VM
authors.lastname: Martín Giménez
authors.affiliation: Departamento de Fisiología, Facultad de Medicina, Universidad Complutense, Madrid, España.
authors.forename: María Belén
authors.initials: MB
authors.lastname: Ruiz-Roso
authors.affiliation: IBAM, UNCuyo, CONICET, Facultad de Ciencias Agrarias, Chacras de Coria, Luján, Mendoza, Argentina; Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Cuyo, Mendoza, Argentina.
authors.forename: Alejandra Beatriz
authors.initials: AB
authors.lastname: Camargo
authors.affiliation: Instituto de Investigación en Ciencias Químicas, Facultad de Ciencias de la Alimentación, Bioquímicas y Farmacéuticas, Universidad Católica de Cuyo, San Juan, San Juan, Argentina.
authors.forename: Diego
authors.initials: D
authors.lastname: Kassuha
authors.affiliation: Instituto de Medicina y Biología Experimental de Cuyo, Consejo Nacional de Investigación Científica y Tecnológica (IMBECU-CONICET), Argentina; Laboratorio de Farmacología Experimental Básica y Traslacional, Área de Farmacología, Departamento de Patología, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Mendoza, Argentina. Electronic address: wmanucha@yahoo.com.ar.
authors.forename: Walter
authors.initials: W
authors.lastname: Manucha
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D018450:Disease Progression; D015195:Drug Design; D006801:Humans; D053758:Nanoparticles; D036103:Nanotechnology
keywords: Alternativas terapéuticas; Aterosclerosis; Atherosclerosis; Diagnosis; Diagnóstico; Nanotechnology; Nanotecnología; Therapeutic alternatives; Tratamiento; Treatment