title: Quantum dots-DNA bioconjugates: synthesis to applications.
abstract: Semiconductor nanoparticles particularly quantum dots (QDs) are interesting alternatives to organic fluorophores for a range of applications such as biosensing, imaging and therapeutics. Addition of a programmable scaffold such as DNA to QDs further expands the scope and applicability of these hybrid nanomaterials in biology. In this review, the most important stages of preparation of QD-DNA conjugates for specific applications in biology are discussed. Special emphasis is laid on (i) the most successful strategies to disperse QDs in aqueous media, (ii) the range of different conjugation with detailed discussion about specific merits and demerits in each case, and (iii) typical applications of these conjugates in the context of biology.
authors.affiliation: Laboratoire de Physique et d'Etude des Matériaux, ESPCI ParisTech, CNRS UMR 8213 , Université Pierre et Marie Curie , 10 Rue Vauquelin, 75005 Paris , France.
authors.forename: Anusuya
authors.identifier: 0000-0003-2132-4330
authors.initials: A
authors.lastname: Banerjee
authors.affiliation: Laboratoire de Physique et d'Etude des Matériaux, ESPCI ParisTech, CNRS UMR 8213 , Université Pierre et Marie Curie , 10 Rue Vauquelin, 75005 Paris , France.
authors.forename: Thomas
authors.identifier: 0000-0001-8800-4302
authors.initials: T
authors.lastname: Pons
authors.affiliation: Laboratoire de Physique et d'Etude des Matériaux, ESPCI ParisTech, CNRS UMR 8213 , Université Pierre et Marie Curie , 10 Rue Vauquelin, 75005 Paris , France.
authors.forename: Nicolas
authors.identifier: 0000-0001-7915-2362
authors.initials: N
authors.lastname: Lequeux
authors.affiliation: Laboratoire de Physique et d'Etude des Matériaux, ESPCI ParisTech, CNRS UMR 8213 , Université Pierre et Marie Curie , 10 Rue Vauquelin, 75005 Paris , France.
authors.forename: Benoit
authors.identifier: 0000-0002-9450-8029
authors.initials: B
authors.lastname: Dubertret
keywords: biosensing and therapeutics; conjugation; purification