title: Efficacy of aspirin (325 mg) + omeprazole (40 mg) in treating coronary artery disease.
abstract: Aspirin is indicated for primary and secondary prevention of cardiovascular diseases (CVD) by major guidelines. However, its use may be associated with gastrointestinal (GI) toxicities, including, but not limited to, GI bleeding. This may lead to increased morbidity and mortality, as well as diminished compliance, which again leads to increased risk of major cardiovascular events. Modified formulations of aspirin often have comparable risks of GI toxicity despite their dose or formulation and have had limited success to prevent GI toxicities. Simultaneous treatment with Proton pump inhibitors (PPIs) has been used successfully to prevent GI toxicities from aspirin. However, addition of an extra medication may lead to lower compliance and hence ineffective or less than optimal treatment. Areas covered: After a selective literature search, a brief review of the available evidence regarding GI toxicity of aspirin and the protective effects of PPIs was conducted. The concept of combination tablets, and the available data about Aralez Pharmaceuticals' YOSPRALA (aspirin (81 mg or 325 mg) and omeprazole (40 mg) fixed dose combination tablet being evaluated for secondary prevention of cardiovascular and cerebrovascular events in patients at risk for GI complications of aspirin therapy) is also presented. Expert opinion: The available evidence suggests that PPIs are the best option to prevent aspirin-related GI toxicities, but compliance is low in people who are prescribed both aspirin and PPI. Combination tablets containing both aspirin and a PPI may be a good option for providing protection against GI toxicities in people who require aspirin for secondary prevention of cardiovascular diseases.
authors.affiliation: a Department of Medicine , Sinai Hospital , Baltimore , MD , USA.
authors.forename: Tushar
authors.initials: T
authors.lastname: Sharma
authors.affiliation: b Director of Cardiovascular Research , Inova Center for Thrombosis Research and Drug Development, Inova Heart and Vascular Institute , Fairfax , VA , USA.
authors.forename: Kevin
authors.initials: K
authors.lastname: Bliden
authors.affiliation: a Department of Medicine , Sinai Hospital , Baltimore , MD , USA.
authors.forename: Rahul
authors.initials: R
authors.lastname: Chaudhary
authors.affiliation: b Director of Cardiovascular Research , Inova Center for Thrombosis Research and Drug Development, Inova Heart and Vascular Institute , Fairfax , VA , USA.
authors.forename: Udaya
authors.initials: U
authors.lastname: Tantry
authors.affiliation: b Director of Cardiovascular Research , Inova Center for Thrombosis Research and Drug Development, Inova Heart and Vascular Institute , Fairfax , VA , USA.
authors.forename: Paul A
authors.initials: PA
authors.lastname: Gurbel
mesh_terms: D001241:Aspirin / Q000008:administration & dosage / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000517:prevention & control; D003324:Coronary Artery Disease / Q000188:drug therapy*; D005767:Gastrointestinal Diseases / Q000517:prevention & control; D006471:Gastrointestinal Hemorrhage / Q000517:prevention & control; D006801:Humans; D009853:Omeprazole / Q000008:administration & dosage / Q000627:therapeutic use*; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use; D054328:Proton Pump Inhibitors / Q000627:therapeutic use; D055502:Secondary Prevention
chemical_list: D010975:Platelet Aggregation Inhibitors; D054328:Proton Pump Inhibitors; D009853:Omeprazole; D001241:Aspirin
keywords: AXANUM; Aspirin; GI bleed; PA; YOSPRALA; cardiovascular event; combination tablets; gastrointestinal toxicity; proton pump inhibitors