title: Oleuropein attenuates the progression of heart failure in rats by antioxidant and antiinflammatory effects.
abstract: Much of the beneficial effects of olive products have been attributed to oleuropein. This study examined the effects of oleuropein in rats with heart failure induced by permanent ligation of left coronary arteries. Twenty-four hours after the operation, the rats were assigned to five groups including a sham assigned to receive vehicle (1 ml/day) and four coronary ligated groups assigned to receive vehicle or oleuropein at 5, 10, or 20 mg/kg/day. Five weeks later, echocardiographic and hemodynamic parameters, serum concentrations of oxidative stress, and inflammatory markers were determined. Myocardial infarction group receiving vehicle showed impaired hemodynamic and echocardiographic parameters as evidenced by decreased left ventricular systolic pressure, rate of rise and decrease of left ventricular pressure, stroke volume, ejection fraction, and cardiac output. In addition, significant reduction in superoxide dismutase and glutathione reductase was observed. Oleuropein treatment prevented the reduction of these variables. Moreover, the group had a significantly higher infarct size and serum malondialdehyde, interleukin-1β, and tumor necrosis factor-α than those of the sham group. Treatment with oleuropein prevented the increase of these variables. The results show that oleuropein attenuates the progression of heart failure, possibly by antioxidative and antiinflammatory effects.
authors.affiliation: Cardiovascular Pharmacology Research Lab, Department of Pharmacology, Medical School, Shiraz University of Medical Sciences, Shiraz, 7134845794, Iran.|Department of Pharmacology, Medical School, Shiraz University of Medical Sciences, Shiraz, 7134845794, Iran.|The Persian Gulf Marine Biotechnology Research Center, Bushehr University of Medical Sciences, Bushehr, 7514763448, Iran.
authors.forename: Zeinab
authors.initials: Z
authors.lastname: Janahmadi
authors.affiliation: Cardiovascular Pharmacology Research Lab, Department of Pharmacology, Medical School, Shiraz University of Medical Sciences, Shiraz, 7134845794, Iran. nekooeiana@sums.ac.ir.|Department of Pharmacology, Medical School, Shiraz University of Medical Sciences, Shiraz, 7134845794, Iran. nekooeiana@sums.ac.ir.|Department of Pharmacology, Medical School, Shiraz University of Medical Sciences, Zand Street, Shiraz, Fars, 7134853185,, Iran. nekooeiana@sums.ac.ir.
authors.forename: Ali Akbar
authors.initials: AA
authors.lastname: Nekooeian
authors.affiliation: Department of Cardiology, Medical School, Shiraz University of Medical Sciences, Shiraz, 7134845794, Iran.|Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, 7134845794, Iran.
authors.forename: Ali Reza
authors.initials: AR
authors.lastname: Moaref
authors.affiliation: Department of Pharmacology, Medical School, Shiraz University of Medical Sciences, Shiraz, 7134845794, Iran.
authors.forename: Masoomeh
authors.initials: M
authors.lastname: Emamghoreishi
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D015415:Biomarkers / Q000097:blood; D004195:Disease Models, Animal; D018450:Disease Progression; D005980:Glutathione Reductase / Q000378:metabolism; D006333:Heart Failure / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000517:prevention & control*; D006439:Hemodynamics / Q000187:drug effects; D018836:Inflammation Mediators / Q000097:blood*; D053583:Interleukin-1beta / Q000097:blood; D057888:Iridoid Glucosides; D039823:Iridoids / Q000494:pharmacology*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D009203:Myocardial Infarction / Q000097:blood / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D018384:Oxidative Stress / Q000187:drug effects*; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D016277:Ventricular Function, Left / Q000187:drug effects
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D015415:Biomarkers; C000594089:IL1B protein, rat; D018836:Inflammation Mediators; D053583:Interleukin-1beta; D057888:Iridoid Glucosides; D039823:Iridoids; D014409:Tumor Necrosis Factor-alpha; C002769:oleuropein; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D005980:Glutathione Reductase
keywords: Heart failure; Inflammatory cytokines; Oleuropein; Oxidative stress; Rat