title: Computed tomography-based survey of the vascular anatomy of the juvenile Göttingen minipig.
abstract: Over the past 50 years, image-guided procedures have been established for a wide range of applications. The development and clinical translation of new treatment regimens necessitate the availability of suitable animal models. The juvenile Göttingen minipig presents a favourable profile as a model for human infants. However, no information can be found regarding the vascular system of juvenile minipigs in the literature. Such information is imperative for planning the accessibility of target structures by catheterization. We present here a complete mapping of the arterial system of the juvenile minipig based on contrast-enhanced computed tomography. Four female animals weighing 6.13 ± 0.72 kg were used for the analyses. Imaging was performed under anaesthesia, and the measurement of the vascular structures was performed independently by four investigators. Our dataset forms a basis for future interventional studies in juvenile minipigs, and enables planning and refinement of future experiments according to the 3R (replacement, reduction and refinement) principles of animal research.
authors.affiliation: 1 Department of Surgery, Campus Charité Mitte | Campus Virchow-Klinikum, Experimental Surgery and Regenerative Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Siefert
authors.affiliation: 1 Department of Surgery, Campus Charité Mitte | Campus Virchow-Klinikum, Experimental Surgery and Regenerative Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: K H
authors.initials: KH
authors.lastname: Hillebrandt
authors.affiliation: 1 Department of Surgery, Campus Charité Mitte | Campus Virchow-Klinikum, Experimental Surgery and Regenerative Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Kluge
authors.affiliation: 2 Department of Diagnostic and Interventional Radiology, Charité - Universitätsmedizin Berlin, Campus Virchow-Klinikum, Berlin, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Geisel
authors.affiliation: 2 Department of Diagnostic and Interventional Radiology, Charité - Universitätsmedizin Berlin, Campus Virchow-Klinikum, Berlin, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Podrabsky
authors.affiliation: 2 Department of Diagnostic and Interventional Radiology, Charité - Universitätsmedizin Berlin, Campus Virchow-Klinikum, Berlin, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Denecke
authors.affiliation: 1 Department of Surgery, Campus Charité Mitte | Campus Virchow-Klinikum, Experimental Surgery and Regenerative Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Nösser
authors.affiliation: 1 Department of Surgery, Campus Charité Mitte | Campus Virchow-Klinikum, Experimental Surgery and Regenerative Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Gassner
authors.affiliation: 1 Department of Surgery, Campus Charité Mitte | Campus Virchow-Klinikum, Experimental Surgery and Regenerative Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Reutzel-Selke
authors.affiliation: 1 Department of Surgery, Campus Charité Mitte | Campus Virchow-Klinikum, Experimental Surgery and Regenerative Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany.|3 BIH-Charité Clinican Scientist Program, Berlin Institute of Health (BIH), Berlin, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Strücker
authors.affiliation: 1 Department of Surgery, Campus Charité Mitte | Campus Virchow-Klinikum, Experimental Surgery and Regenerative Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: M H
authors.initials: MH
authors.lastname: Morgul
authors.affiliation: 1 Department of Surgery, Campus Charité Mitte | Campus Virchow-Klinikum, Experimental Surgery and Regenerative Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Guel-Klein
authors.affiliation: 4 Department of Experimental Medicine, Charité - Universitaütsmedizin Berlin, Berlin, Germany.
authors.forename: J K
authors.initials: JK
authors.lastname: Unger
authors.affiliation: 5 Department of Anaesthesiology and Intensive Care Medicine, University Hospital Leipzig, Leipzig, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Reske
authors.affiliation: 1 Department of Surgery, Campus Charité Mitte | Campus Virchow-Klinikum, Experimental Surgery and Regenerative Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Pratschke
authors.affiliation: 1 Department of Surgery, Campus Charité Mitte | Campus Virchow-Klinikum, Experimental Surgery and Regenerative Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: I M
authors.initials: IM
authors.lastname: Sauer
authors.affiliation: 1 Department of Surgery, Campus Charité Mitte | Campus Virchow-Klinikum, Experimental Surgery and Regenerative Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany.|3 BIH-Charité Clinican Scientist Program, Berlin Institute of Health (BIH), Berlin, Germany.
authors.forename: N
authors.initials: N
authors.lastname: Raschzok
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000033:anatomy & histology*; D005260:Female; D006801:Humans; D023421:Models, Animal; D012039:Regional Blood Flow; D011795:Surveys and Questionnaires; D013552:Swine; D013556:Swine, Miniature / Q000033:anatomy & histology*; D014057:Tomography, X-Ray Computed
keywords: 3Rs; animal model; circulatory physiology; pigs