title: A case of musical anhedonia due to right putaminal hemorrhage: a disconnection syndrome between the auditory cortex and insula.
abstract: A 63-year-old, right-handed professional chorus conductor developed right putaminal hemorrhage, and became unable to experience emotion while listening to music. Two years later, neurological examination revealed slight left hemiparesis. Neuromusicological assessments revealed impaired judgment of "musical sense," and the inability to discriminate the sound of chords in pure intervals from those in equal temperament. Brain MRI and tractography identified the old hemorrhagic lesion in the right putamen and impaired fiber connectivity between the right insula and superior temporal lobe. These findings suggest that musical anhedonia might be caused by a disconnection between the insula and auditory cortex.
authors.affiliation: a Department of Dementia Prevention and Therapeutics, Graduate School of Medicine , Mie University , Tsu , Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Satoh
authors.affiliation: b Department of Neurology, Graduate School of Medicine , Mie University , Tsu , Japan.
authors.forename: Natsuko
authors.initials: N
authors.lastname: Kato
authors.affiliation: a Department of Dementia Prevention and Therapeutics, Graduate School of Medicine , Mie University , Tsu , Japan.
authors.forename: Ken-Ichi
authors.initials: KI
authors.lastname: Tabei
authors.affiliation: a Department of Dementia Prevention and Therapeutics, Graduate School of Medicine , Mie University , Tsu , Japan.
authors.forename: Chizuru
authors.initials: C
authors.lastname: Nakano
authors.affiliation: a Department of Dementia Prevention and Therapeutics, Graduate School of Medicine , Mie University , Tsu , Japan.
authors.forename: Makiko
authors.initials: M
authors.lastname: Abe
authors.affiliation: a Department of Dementia Prevention and Therapeutics, Graduate School of Medicine , Mie University , Tsu , Japan.
authors.forename: Risa
authors.initials: R
authors.lastname: Fujita
authors.affiliation: a Department of Dementia Prevention and Therapeutics, Graduate School of Medicine , Mie University , Tsu , Japan.
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Kida
authors.affiliation: a Department of Dementia Prevention and Therapeutics, Graduate School of Medicine , Mie University , Tsu , Japan.|b Department of Neurology, Graduate School of Medicine , Mie University , Tsu , Japan.
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Tomimoto
authors.affiliation: c Department of Neurology , Yoka Hospital , Yabu , Japan.
authors.forename: Kiyohiko
authors.initials: K
authors.lastname: Kondo
mesh_terms: D059445:Anhedonia / Q000502:physiology*; D001303:Auditory Cortex / Q000000981:diagnostic imaging / Q000473:pathology*; D001307:Auditory Perception; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000473:pathology*; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009146:Music; D009434:Neural Pathways / Q000000981:diagnostic imaging / Q000502:physiology; D059906:Neuroimaging; D009460:Neurologic Examination; D020146:Putaminal Hemorrhage / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology / Q000523:psychology
keywords: auditory cortex; disconnection; insula; musical anhedonia; putaminal hemorrhage