title: The role of HGF/c-MET signaling pathway in lymphoma.
abstract: Inappropriate activation of c-mesenchymal-epithelial transition (MET), the receptor tyrosine kinase (RTK) for hepatocyte growth factor (HGF), has been implicated in tumorigenesis and represented a promising therapeutic target for developing anticancer agents. In contrast to other solid tumors, there are limited data describing the functional role of HGF/c-MET signaling pathway in lymphoma. In the current review, we summarize recent findings about the expression, cellular mechanisms/functions, and therapeutic application of HGF/c-MET in different types of lymphoma, especially B cell lymphoma, T and NK cell lymphoma, and Hodgkin lymphoma. We also discuss the existing problems and future directions about studying the HGF/c-MET pathway in lymphoma cells.
authors.affiliation: Departments of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, Louisiana Cancer Research Center, Suite 902, 1700 Tulane Ave., New Orleans, LA, 70112, USA.
authors.forename: Bao Quoc
authors.initials: BQ
authors.lastname: Lam
authors.affiliation: Departments of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, Louisiana Cancer Research Center, Suite 902, 1700 Tulane Ave., New Orleans, LA, 70112, USA.|Department of Oncology, Research Center for Translational Medicine and Key Laboratory of Arrhythmias, East Hospital, Tongji University School of Medicine, Shanghai, 200120, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Dai
authors.affiliation: Departments of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, Louisiana Cancer Research Center, Suite 902, 1700 Tulane Ave., New Orleans, LA, 70112, USA. zqin@lsuhsc.edu.|Department of Oncology, Research Center for Translational Medicine and Key Laboratory of Arrhythmias, East Hospital, Tongji University School of Medicine, Shanghai, 200120, China. zqin@lsuhsc.edu.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Qin
mesh_terms: D000818:Animals; D017228:Hepatocyte Growth Factor / Q000378:metabolism; D006801:Humans; D008223:Lymphoma / Q000378:metabolism*; D019859:Proto-Oncogene Proteins c-met / Q000378:metabolism; D015398:Signal Transduction
chemical_list: C066855:HGF protein, human; D017228:Hepatocyte Growth Factor; D019859:Proto-Oncogene Proteins c-met
keywords: HGF; Inhibitor; Lymphoma; MET