title: Is LukS-PV a novel experimental therapy for leukemia?
abstract: Although the studies on the pathogenesis and prognosis of leukemia have made revolutionary progress, the long-term survival remains unsatisfactory. Alternative techniques are being developed to target leukemia. Several decades after researchers' work, a variety of bacteria toxins are being explored as potential anti-leukemia agents, either to provide direct effects or to deliver therapeutic proteins to leukemia. LukS-PV, a component of Panton-Valentine Leukocidin secreted by S. aureus, has been tested in acute myeloid leukemia as a novel experimental strategy. Further researches about the targeting mechanisms of LukS-PV are required to make it a complete therapeutic approach for leukemia treatment. The function of this article is to provide clinicians and experimentalists with a chronological and comprehensive appraisal of use of LukS-PV as an experimental strategy for leukemia therapy.
authors.affiliation: Department of Clinical Laboratory, The west branch of Anhui Provincial Hospital (Anhui Provincial Cancer Hospital), Hefei, 230031, PR China.
authors.forename: Wulin
authors.initials: W
authors.lastname: Shan
authors.affiliation: Department of Laboratory Medicine, Anhui, Provincial Hospital, Hefei 230001, PR China. Electronic address: xiaolingma1962@sina.cn.
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Ma
authors.affiliation: Department of Clinical Laboratory, The west branch of Anhui Provincial Hospital (Anhui Provincial Cancer Hospital), Hefei, 230031, PR China.
authors.forename: Fang
authors.initials: F
authors.lastname: Deng
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols; D001426:Bacterial Proteins / Q000627:therapeutic use*; D001427:Bacterial Toxins / Q000008:administration & dosage / Q000627:therapeutic use*; D002454:Cell Differentiation / Q000187:drug effects; D045744:Cell Line, Tumor; D004355:Drug Stability; D005098:Exotoxins / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007938:Leukemia / Q000188:drug therapy* / Q000473:pathology; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000473:pathology; D007956:Leukocidins / Q000008:administration & dosage / Q000627:therapeutic use*; D035703:Therapies, Investigational / Q000639:trends
chemical_list: D000970:Antineoplastic Agents; D001426:Bacterial Proteins; D001427:Bacterial Toxins; D005098:Exotoxins; D007956:Leukocidins; C078284:Panton-Valentine leukocidin; C108483:leukocidin S-component protein, Staphylococcus
keywords: Bacteria toxin; C5aR; Leukemia; LukS-PV; Panton-valentine leukocidin