title: Relationship between IL-10 gene -819C/T polymorphism and the risk of inflammatory bowel disease: a meta-analysis.
abstract: BACKGROUND
  The -819C/T polymorphism in interleukin 10 (IL-10) gene has been reported to be associated with inflammatory bowel disease (IBD), but the previous results are conflicting.
  
  
  METHODS
  The present study aimed at investigating the association between this polymorphism and risk of IBD using a meta-analysis.PubMed, Web of Science,EMBASE,google scholar and China National Knowledge Infrastructure (CNKI) databases were systematically searched to identify relevant publications from their inception to April 2016.Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using fixed- or random-effects models.
  
  
  RESULTS
  A total of 7 case-control studies containing 1890 patients and 2929 controls were enrolled into this meta-analysis, and our results showed no association between IL-10 gene -819C/T polymorphism and IBD risk(TT vs. CC:OR=0.81,95%CI 0.64-1.04;CT vs. CC:OR=0.92,95%CI 0.81-1.05; Dominant model: OR=0.90,95%CI 0.80-1.02; Recessive model: OR=0.84,95%CI 0.66-1.06). In a subgroup analysis by nationality, the -819C/T polymorphism was not associated with IBD in both Asians and Caucasians. In the subgroup analysis stratified by IBD type, significant association was found in Crohn's disease(CD)(CT vs. CC:OR=0.68,95%CI 0.48-0.97).
  
  
  CONCLUSIONS
  In summary, the present meta-analysis suggests that the IL-10 gene -819C/T polymorphism may be associated with CD risk.
authors.affiliation: Department of Gastroenterology, Guangzhou Red Cross Hospital, Medical College, Jinan University, Guangzhou 510220, China; Department of Gastroenterology, Jiangmen Central Hospital, Jiangmen 529030, China.
authors.forename: Haien
authors.initials: H
authors.lastname: Wu
authors.affiliation: Department of Nephrology, Jiangmen Central Hospital, Jiangmen 529030, China.
authors.forename: JingJing
authors.initials: J
authors.lastname: Guo
authors.affiliation: Center of Clinical Laboratory Medicine, Guangzhou Red Cross Hospital, Medical College, Jinan University, Guangzhou 510220, China.
authors.forename: Yajun
authors.initials: Y
authors.lastname: He
authors.affiliation: Department of Gastroenterology, Jiangmen Central Hospital, Jiangmen 529030, China.
authors.forename: Hekun
authors.initials: H
authors.lastname: Yin
authors.affiliation: Department of Gastroenterology, Guangzhou Red Cross Hospital, Medical College, Jinan University, Guangzhou 510220, China.
authors.forename: Jianchang
authors.initials: J
authors.lastname: Shu
mesh_terms: D002681:China; D020022:Genetic Predisposition to Disease; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000235:genetics*; D016753:Interleukin-10 / Q000235:genetics*; D016017:Odds Ratio; D011110:Polymorphism, Genetic
chemical_list: D016753:Interleukin-10
keywords: -819C/T polymorphism; Interleukin 10; inflammatory bowel disease