title: Beverage Intake and Metabolic Syndrome Risk Over 14 Years: The Study of Women's Health Across the Nation.
abstract: BACKGROUND
  Alcohol and energy-dense beverages consumption have been implicated in cardiometabolic disease, albeit inconsistently.
  
  
  OBJECTIVE
  This study tested prospective associations between intakes of alcohol, energy-dense beverages, and low-calorie beverages and cardiometabolic risk in midlife women.
  
  
  METHODS
  The Study of Women's Health Across the Nation is a 14-year, multisite prospective cohort study (1996-2011). Beverage intake and cardiometabolic risk factors that define the metabolic syndrome (hypertension, abdominal obesity, impaired fasting glucose, low high-density lipoprotein cholesterol level, and hypertriglyceridemia) were assessed throughout follow-up.
  
  
  METHODS
  Participants (N=1,448) were African American, Chinese, Japanese, and non-Hispanic white midlife women from six US cities.
  
  
  METHODS
  The primary outcomes were incident metabolic syndrome and the individual metabolic syndrome components.
  
  
  METHODS
  Generalized linear mixed models tested associations between intakes within each beverage category and odds of meeting criteria for metabolic syndrome and each of the metabolic syndrome components.
  
  
  RESULTS
  Energy-dense beverage consumption was highest among African-American women and lowest among women with college degrees. Non-Hispanic white women consumed the largest quantities of alcohol. Independent of energy intake and potential confounders, each additional 355 mL energy-dense beverages consumed per day was associated with higher odds of developing metabolic syndrome in each successive year of follow-up (odds ratio [OR] 1.05, 95% CI 1.02 to 1.08). Greater energy-dense beverage intake was associated with more rapidly increasing odds of developing hypertension (OR 1.06, 95% CI 1.02 to 1.11) and abdominal obesity (OR 1.10, 95% CI 1.03 to 1.16) over time, but not with the other metabolic syndrome components. Intakes of alcohol and low-calorie coffees, teas, and diet cola were not associated with metabolic syndrome risk.
  
  
  CONCLUSIONS
  Over 14 years of follow-up, energy-dense nonalcoholic beverage consumption was associated with incident metabolic syndrome in midlife women. The observed differences in intakes by ethnicity/race and education suggest that consumption of these beverages may contribute to disparities in risk factors for diabetes and cardiovascular disease.
authors.forename: Bradley M
authors.initials: BM
authors.lastname: Appelhans
authors.forename: Ana
authors.initials: A
authors.lastname: Baylin
authors.forename: Mei-Hua
authors.initials: MH
authors.lastname: Huang
authors.forename: Hong
authors.initials: H
authors.lastname: Li
authors.forename: Imke
authors.initials: I
authors.lastname: Janssen
authors.forename: Rasa
authors.initials: R
authors.lastname: Kazlauskaite
authors.forename: Elizabeth F
authors.initials: EF
authors.lastname: Avery
authors.forename: Howard M
authors.initials: HM
authors.lastname: Kravitz
mesh_terms: D000328:Adult; D001741:Black or African American; D044466:Asian People; D001628:Beverages / Q000009:adverse effects*; D002149:Energy Intake; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D024821:Metabolic Syndrome / Q000453:epidemiology*; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D012959:Socioeconomic Factors; D014481:United States; D055105:Waist Circumference; D044465:White People; D016387:Women's Health
keywords: Alcoholic beverages; Beverages; Hypertension; Metabolic syndrome