title: Depressive symptoms in Parkinson's disease correlate with cortical atrophy over time.
abstract: Depressive symptoms are very common in patients with Parkinson's disease (PD) and have a significant impact on the quality of life.
  
  
  
  The present study analyzed the correlations between over-time changes in depressive symptoms and gray matter parameters of cortical thickness and subcortical volumes in non-demented PD patients.
  
  
  
  A significant correlation was observed, between increased scores for depression over time and lower cortical thickness over time in the right temporo-parietal junction, right occipital medial region, right dorsolateral prefrontal cortex, right posterior cingulate region, left middle temporal as well as left supplementary motor area. Furthermore, the presence of depressive symptoms at baseline predicted increased cortical thinning over time in the left middle temporal, left anterior cingulate, right posterior cingulate and right parahippocampal cortices. Finally, a statistically significant negative correlation has been revealed between the thalamus' volume changes over time and the change in depressive symptoms scores. All other analyzed subcortical structures didn't reveal any significant correlations.
  
  
  
  These results suggest that depressive symptoms in PD patients are associated with gray matter cortical thinning and thalamus volume shrinkage over time and higher scores of depressive symptoms at baseline correlate with a higher rate of cortical thinning longitudinally. The present study highlights the importance of addressing depressive symptoms in PD patients early in the disease.
authors.affiliation: Department of Clinical Neurosciences and Department of Radiology, University of Calgary, Calgary, AB, Canada; Hotchkiss Brain Institute, Calgary, AB, Canada; Centre de Recherche, Institut Universitaire de Gériatrie de Montréal, Montréal, QC, Canada. Electronic address: alexandru.hanganu@ucalgary.ca.
authors.forename: Alexandru
authors.initials: A
authors.lastname: Hanganu
authors.affiliation: Centre de Recherche, Institut Universitaire de Gériatrie de Montréal, Montréal, QC, Canada. Electronic address: ma.bruneau@videotron.ca.
authors.forename: Marie-Andrée
authors.initials: MA
authors.lastname: Bruneau
authors.affiliation: Centre de Recherche, Institut Universitaire de Gériatrie de Montréal, Montréal, QC, Canada; Montreal Neurological Institute and Hospital, McGill University, Montréal, QC, Canada. Electronic address: clotilde.degroot@mcgill.ca.
authors.forename: Clotilde
authors.initials: C
authors.lastname: Degroot
authors.affiliation: Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré Cœur de Montréal, Montréal, QC, Canada. Electronic address: christophe.bedetti@criugm.qc.ca.
authors.forename: Christophe
authors.initials: C
authors.lastname: Bedetti
authors.affiliation: Centre de Recherche, Institut Universitaire de Gériatrie de Montréal, Montréal, QC, Canada. Electronic address: beatriz.mejia-constain@umontreal.ca.
authors.forename: Béatriz
authors.initials: B
authors.lastname: Mejia-Constain
authors.affiliation: Montreal Neurological Institute and Hospital, McGill University, Montréal, QC, Canada; Movement Disorders Unit, McGill University Health Centre, Montréal, QC, Canada. Electronic address: anne-louise.lafontaine@mcgill.ca.
authors.forename: Anne-Louise
authors.initials: AL
authors.lastname: Lafontaine
authors.affiliation: Unité des troubles du mouvement André Barbeau, Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada. Electronic address: sylvainchouinard@me.com.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Chouinard
authors.affiliation: Department of Clinical Neurosciences and Department of Radiology, University of Calgary, Calgary, AB, Canada; Hotchkiss Brain Institute, Calgary, AB, Canada; Centre de Recherche, Institut Universitaire de Gériatrie de Montréal, Montréal, QC, Canada; Montreal Neurological Institute and Hospital, McGill University, Montréal, QC, Canada. Electronic address: oury.monchi@ucalgary.ca.
authors.forename: Oury
authors.initials: O
authors.lastname: Monchi
mesh_terms: D000368:Aged; D001284:Atrophy / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology*; D003863:Depression / Q000523:psychology*; D003866:Depressive Disorder; D018450:Disease Progression; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000473:pathology* / Q000523:psychology*; D013788:Thalamus / Q000473:pathology*
keywords: Cortical thickness; Depressive symptoms; Longitudinal analysis; Parkinson’s disease