title: Bifurcation Type and Larger Low Shear Area Are Associated with Rupture Status of Very Small Intracranial Aneurysms.
abstract: BACKGROUND
  Characterization of the risk factors for rupture of very small intracranial aneurysm (VSIA, ≤3 mm) is clinically valuable, since VSIAs are implicated in subarachnoid hemorrhage. The aim of this study was to identify morphological and hemodynamic parameters that independently characterize the rupture status of VSIAs.
  
  
  METHODS
  We conducted a retrospective study of consecutive VSIAs between September 2010 and February 2014 in our institute. A series of morphologic and hemodynamic parameters were evaluated using computational fluid dynamics, based on patient-specific three-dimensional geometrical models.
  
  
  RESULTS
  We identified 186 patients with 206 VSIAs (73 ruptured, 133 unruptured). Univariable logistic regression analysis showed that bifurcation type, parent artery diameter, size ratio, time-averaged wall shear stress (WSS), maximum WSS, minimum WSS, and low shear area (LSA) were related to rupture status. Bifurcation type and larger LSA were independently associated with rupture status in multivariable logistic regression (p= 0.002 andp= 0.003, respectively).
  
  
  CONCLUSIONS
  Bifurcation type and larger LSA were independently associated with VSIA rupture status. Further studies are needed prospectively on patient-derived geometries prior to rupturing based on large multi-population data to confirm the present findings.
authors.affiliation: Department of Interventional Neuroradiology, Beijing Neurosurgical Institute and Beijing Tian Tan Hospital, Capital Medical University , Beijing , China.
authors.forename: Yisen
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Interventional Neuroradiology, Beijing Neurosurgical Institute and Beijing Tian Tan Hospital, Capital Medical University , Beijing , China.
authors.forename: Zhongbin
authors.initials: Z
authors.lastname: Tian
authors.affiliation: Department of Interventional Neuroradiology, Beijing Neurosurgical Institute and Beijing Tian Tan Hospital, Capital Medical University , Beijing , China.
authors.forename: Linkai
authors.initials: L
authors.lastname: Jing
authors.affiliation: Department of Interventional Neuroradiology, Beijing Neurosurgical Institute and Beijing Tian Tan Hospital, Capital Medical University , Beijing , China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Interventional Neuroradiology, Beijing Neurosurgical Institute and Beijing Tian Tan Hospital, Capital Medical University , Beijing , China.
authors.forename: Jian
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Interventional Neuroradiology, Beijing Neurosurgical Institute and Beijing Tian Tan Hospital, Capital Medical University , Beijing , China.
authors.forename: Xinjian
authors.initials: X
authors.lastname: Yang
keywords: aneurysm type; bifurcation type; hemodynamics; rupture; very small intracranial aneurysm; wall shear stress