title: Ischaemia-modified albumin in preeclampsia: A critical view.
abstract: The aim of the study was to compare ischaemia-modified albumin (IMA) levels, both original and corrected, in healthy pregnancies and pregnancies complicated with preeclampsia. Maternal and cord blood samples from study (n = 16) and control (n = 17) groups were collected at the time of delivery. IMA levels were given in absorbance units (ABSU). IMA levels, both original and corrected, were compared between study and control groups. No significant difference was found between maternal and cord blood IMA levels between the study and control groups [1.0 (0.3-3.5) vs 1.2 (0.2-1.4) ABSU, p = .053 and 1.0 (0.1-2.2) vs 0.9 (0.4-3.6) ABSU, p = .382, respectively]. The results were similar for maternal IMA levels, after correction of IMA levels [1.1 (0.3-5.1) vs 1.2 (0.2-1.6) ABSU, p = .292]. IMA is a novel marker for ischaemia, without precise conclusions about its value in preeclampsia. An absolute correction formula, considering all possible intervening factors, is required for more accurate results.
authors.affiliation: a Obstetrics and Gynecology Department , Ufuk University Faculty of Medicine , Ankara , Turkey.
authors.forename: Aslı
authors.initials: A
authors.lastname: Yarcı Gursoy
authors.affiliation: b Obstetrics and Gynaecology Department , Aksaray State Hospital , Aksaray , Turkey.
authors.forename: Elif Didem
authors.initials: ED
authors.lastname: Ozdemir
authors.affiliation: b Obstetrics and Gynaecology Department , Aksaray State Hospital , Aksaray , Turkey.
authors.forename: Halis
authors.initials: H
authors.lastname: Ozdemir
authors.affiliation: c Biochemistry Department , Ufuk University Faculty of Medicine , Ankara , Turkey.
authors.forename: Tuba
authors.initials: T
authors.lastname: Candar
authors.affiliation: a Obstetrics and Gynecology Department , Ufuk University Faculty of Medicine , Ankara , Turkey.
authors.forename: Gamze Sinem
authors.initials: GS
authors.lastname: Caglar
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001724:Birth Weight; D016022:Case-Control Studies; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D006801:Humans; D007231:Infant, Newborn; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D012709:Serum Albumin; D000075462:Serum Albumin, Human; D018709:Statistics, Nonparametric; D055815:Young Adult
chemical_list: D015415:Biomarkers; D012709:Serum Albumin; C561522:ischemia-modified albumin; D000075462:Serum Albumin, Human
keywords: Maternal; cord blood; ischaemia-modified albumin; preeclampsia