title: Tectal-derived interneurons contribute to phasic and tonic inhibition in the visual thalamus.
abstract: The release of GABA from local interneurons in the dorsal lateral geniculate nucleus (dLGN-INs) provides inhibitory control during visual processing within the thalamus. It is commonly assumed that this important class of interneurons originates from within the thalamic complex, but we now show that during early postnatal development Sox14/Otx2-expressing precursor cells migrate from the dorsal midbrain to generate dLGN-INs. The unexpected extra-diencephalic origin of dLGN-INs sets them apart from GABAergic neurons of the reticular thalamic nucleus. Using optogenetics we show that at increased firing rates tectal-derived dLGN-INs generate a powerful form of tonic inhibition that regulates the gain of thalamic relay neurons through recruitment of extrasynaptic high-affinity GABAAreceptors. Therefore, by revising the conventional view of thalamic interneuron ontogeny we demonstrate how a previously unappreciated mesencephalic population controls thalamic relay neuron excitability.
authors.affiliation: Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 125 Coldharbour Lane, London SE5 9NU, UK.
authors.forename: Polona
authors.initials: P
authors.lastname: Jager
authors.affiliation: Department of Life Sciences, Imperial College London, London SW7 2AZ, UK.
authors.forename: Zhiwen
authors.initials: Z
authors.lastname: Ye
authors.affiliation: Department of Life Sciences, Imperial College London, London SW7 2AZ, UK.
authors.forename: Xiao
authors.initials: X
authors.lastname: Yu
authors.affiliation: Biomedical Research Foundation Academy of Athens, 4 Soranou Ephessiou Street, 115 27 Athens, Greece.
authors.forename: Laskaro
authors.initials: L
authors.lastname: Zagoraiou
authors.affiliation: Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 125 Coldharbour Lane, London SE5 9NU, UK.
authors.forename: Hong-Ting
authors.initials: HT
authors.lastname: Prekop
authors.affiliation: Department of Biosciences, University of Helsinki, PO Box 56, 00014 Helsinki, Finland.
authors.forename: Juha
authors.initials: J
authors.lastname: Partanen
authors.affiliation: Howard Hughes Medical Institute, Columbia University, 701 West 168th Street, HHSC Room 1013, New York, New York 10032, USA.
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Jessell
authors.affiliation: Department of Life Sciences, Imperial College London, London SW7 2AZ, UK.|Centre for Neurotechnology, Imperial College London, London SW7 2AZ, UK.
authors.forename: William
authors.identifier: 0000-0003-4743-0334
authors.initials: W
authors.lastname: Wisden
authors.affiliation: Department of Life Sciences, Imperial College London, London SW7 2AZ, UK.|Centre for Neurotechnology, Imperial College London, London SW7 2AZ, UK.
authors.forename: Stephen G
authors.identifier: 0000-0002-0930-7346
authors.initials: SG
authors.lastname: Brickley
authors.affiliation: Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 125 Coldharbour Lane, London SE5 9NU, UK.
authors.forename: Alessio
authors.initials: A
authors.lastname: Delogu
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D019070:Cell Lineage; D002465:Cell Movement; D005829:Geniculate Bodies / Q000166:cytology; D007395:Interneurons / Q000502:physiology*; D008297:Male; D008810:Mice, Inbred C57BL; D009433:Neural Inhibition / Q000502:physiology*; D051857:Otx Transcription Factors / Q000378:metabolism; D055749:SOXB2 Transcription Factors / Q000378:metabolism; D013234:Stem Cells / Q000378:metabolism; D013477:Superior Colliculi / Q000502:physiology*; D013788:Thalamus / Q000502:physiology*; D014795:Visual Pathways / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D015415:Biomarkers; D051857:Otx Transcription Factors; C497660:Otx2 protein, mouse; D055749:SOXB2 Transcription Factors; D005680:gamma-Aminobutyric Acid