title: PPARβ/δ: A master regulator of mesenchymal stem cell functions.
abstract: Peroxisome proliferator-activated receptors (PPARs) have emerged as key regulators of physiological and immunological processes. Recently, one of their members PPARβ/δ has been identified as major player in the maintenance of bone homeostasis, by promoting Wnt signalling activity in osteoblast and mesenchymal stem cells (MSC). PPARβ/δ not only controls the fate of MSC but also regulates their immunosuppressive properties by directly modulating their NF-κB activity. In this review, we discuss how the regulation of PPARβ/δ provides an innovative strategy for an optimisation of MSC-based therapy.
authors.affiliation: Inserm U1183, Montpellier, F-34295, France; University of Montpellier, Montpellier, F-34000, France. Electronic address: farida.djouad@inserm.fr.
authors.forename: Farida
authors.initials: F
authors.lastname: Djouad
authors.affiliation: Cardiff University, Division of Infection and Immunity, Cardiff, United Kingdom.
authors.forename: Natacha
authors.initials: N
authors.lastname: Ipseiz
authors.affiliation: Laboratorio de Inmunología Celular y Molecular, Centro de Investigación Biomédica, Facultad de Medicina, Universidad de los Andes, Santiago, Chile.
authors.forename: Patricia
authors.initials: P
authors.lastname: Luz-Crawford
authors.affiliation: Department of Internal Medicine 3 and Institute for Clinical Immunology, University Hospital Erlangen, Erlangen, Germany; Nikolaus-Fiebiger Center for Molecular Medicine, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
authors.forename: Carina
authors.initials: C
authors.lastname: Scholtysek
authors.affiliation: Department of Internal Medicine 3 and Institute for Clinical Immunology, University Hospital Erlangen, Erlangen, Germany; Nikolaus-Fiebiger Center for Molecular Medicine, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
authors.forename: Gerhard
authors.initials: G
authors.lastname: Krönke
authors.affiliation: Inserm U1183, Montpellier, F-34295, France; University of Montpellier, Montpellier, F-34000, France; Service d'Immuno-Rhumatologie, Hôpital Lapeyronie, Montpellier, F-34295, France.
authors.forename: Christian
authors.initials: C
authors.lastname: Jorgensen
mesh_terms: D000818:Animals; D006801:Humans; D007108:Immune Tolerance; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000276:immunology; D010012:Osteogenesis / Q000502:physiology; D047495:PPAR gamma / Q000502:physiology*; D048068:PPAR-beta / Q000502:physiology*
chemical_list: D047495:PPAR gamma; D048068:PPAR-beta