title: Nucleotide modifications in messenger RNA and their role in development and disease.
abstract: Modified nucleotides in messenger RNA (mRNA) have been discovered over 40 years ago, but until recently little was known about which transcripts contain them and what their function is. High-throughput sequencing approaches revealed a dynamic landscape of the 'Epitranscriptome' for many mRNA modifications in various organisms from yeast to humans. Meanwhile, also many genes encoding mRNA-modifying enzymes and auxiliary proteins have been identified yielding functional insights by reverse genetics into their role in development and disease.
authors.affiliation: School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.
authors.forename: Veronica
authors.initials: V
authors.lastname: Dezi
authors.affiliation: School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.
authors.forename: Chavdar
authors.initials: C
authors.lastname: Ivanov
authors.affiliation: School of Life Science, Faculty of Health and Life Sciences, Coventry University, Coventry CV1 5FB, U.K.
authors.forename: Irmgard U
authors.initials: IU
authors.lastname: Haussmann
authors.affiliation: School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.
authors.forename: Matthias
authors.initials: M
authors.lastname: Soller
mesh_terms: D000818:Animals; D017360:Arabidopsis / Q000235:genetics; D017173:Caenorhabditis elegans / Q000235:genetics; D004194:Disease / Q000235:genetics*; D004331:Drosophila melanogaster / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D009154:Mutation; D009711:Nucleotides / Q000235:genetics*; D017393:RNA Editing; D012333:RNA, Messenger / Q000235:genetics*; D012441:Saccharomyces cerevisiae / Q000235:genetics
chemical_list: D009711:Nucleotides; D012333:RNA, Messenger
keywords: RNA editing; epitranscriptome; mRNA methylation