title: Toll-Like Receptors in the Progression of Autosomal Dominant Polycystic Kidney Disease.
abstract: Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary cause of chronic kidney disease. The intriguing role of innate immune system and inflammation become a target for potential therapeutic approach to slow progression. When toll-like receptors (TLRs) signaling and their receptors activate, they start a cascade of intracellular signaling that induces the production of the inflammatory cytokines and chemokines. Thus, we aim to investigate the association of TLRs between progression of ADPKD. Ninety ADPKD patients and ninety matched controls were enrolled this prospective study and were followed during 3 years. TLR-2 and TLR-4 gene polymorphisms and expressions were measured. Hypertension was diagnosed with ambulatory blood pressure monitoring. Rapid progression was defined as sustained decline in estimated glomerular filtration rate (eGFR) of more than 5 mL/min per 1.73 m2per year. TLR-4Asp299Gly polymorphisms were significantly different between patient and control group (P < 0.05). Also, TLR-2 and TLR-4 gene expressions were significantly different between the ADPKD patients and the control subjects (P < 0.05). The expression levels of both TLR-2 and TLR-4 were found to be higher in the rapid progression groups comparing the slow progression group (P < 0.05). TLR-2 gene expression, hypertension and uric acid were found to be independent risk factors in identifying rapid progression in ADPKD patients. TLR-2 and TLR-4 gene expressions are associated with rapid progression in ADPKD patients. TLRs may play a role in the progression of ADPKD.
authors.affiliation: Erciyes University Medical Faculty, Department of Internal Medicine, Division of Nephrology, Kayseri, Turkey.
authors.forename: Ismail
authors.initials: I
authors.lastname: Kocyigit
authors.affiliation: Erciyes University Medical Faculty, Department of Medical Biology, Kayseri, Turkey.
authors.forename: Elif Funda
authors.initials: EF
authors.lastname: Sener
authors.affiliation: Erciyes University Medical Faculty, Department of Medical Biology, Kayseri, Turkey.
authors.forename: Serpil
authors.initials: S
authors.lastname: Taheri
authors.affiliation: Erciyes University Medical Faculty, Department of Internal Medicine, Kayseri, Turkey.
authors.forename: Eray
authors.initials: E
authors.lastname: Eroglu
authors.affiliation: Erciyes University Medical Faculty, Department of Internal Medicine, Kayseri, Turkey.
authors.forename: Fahir
authors.initials: F
authors.lastname: Ozturk
authors.affiliation: Erciyes University Medical Faculty, Department of Internal Medicine, Division of Nephrology, Kayseri, Turkey.
authors.forename: Aydin
authors.initials: A
authors.lastname: Unal
authors.affiliation: Erciyes University Medical Faculty, Department of Bioistatistics, Kayseri, Turkey.
authors.forename: Gokmen
authors.initials: G
authors.lastname: Zararsiz
authors.affiliation: Erciyes University Medical Faculty, Department of Internal Medicine, Kayseri, Turkey.
authors.forename: Ilknur
authors.initials: I
authors.lastname: Uzun
authors.affiliation: Erciyes University Medical Faculty, Department of Radiology, Kayseri, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Imamoglu
authors.affiliation: Erciyes University Medical Faculty, Department of Internal Medicine, Division of Nephrology, Kayseri, Turkey.
authors.forename: Murat Hayri
authors.initials: MH
authors.lastname: Sipahioglu
authors.affiliation: Erciyes University Medical Faculty, Department of Internal Medicine, Division of Nephrology, Kayseri, Turkey.
authors.forename: Bulent
authors.initials: B
authors.lastname: Tokgoz
authors.affiliation: Erciyes University Medical Faculty, Department of Internal Medicine, Division of Nephrology, Kayseri, Turkey.
authors.forename: Oktay
authors.initials: O
authors.lastname: Oymak
authors.affiliation: Istanbul Bilim University Medical Faculty, Department of Internal Medicine, Division of Nephrology, Istanbul, Turkey.
authors.forename: Tevfik
authors.initials: T
authors.lastname: Ecder
mesh_terms: D000328:Adult; D018450:Disease Progression; D005260:Female; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000276:immunology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D016891:Polycystic Kidney, Autosomal Dominant / Q000150:complications / Q000276:immunology* / Q000503:physiopathology*; D051193:Toll-Like Receptors / Q000276:immunology*
chemical_list: D051193:Toll-Like Receptors
keywords: Inflammation; Polycystic kidney disease; Toll-like receptors