title: Pd-Catalyzed Site-Selective p-Hydroxyphenyloxylation of Benzylic α-C(sp3)-H Bonds with 1,4-Benzoquinone.
abstract: A Pd-catalyzed, site-selective p-hydroxyphenyloxylation of benzylic α-C(sp3)-H bonds with 1,4-benzoquinone using thioamide as a directing group is reported. 1,4-Benzoquinone is employed as the p-hydroxyphenyloxy source without extra oxidants. This method exclusively gives site selectivity at α-C(sp3)-H bonds rather than the usual β-C(sp3)-H bonds through C-H activation mode. The reactions proceed with high functional group tolerance in yields of 42-93%.
authors.affiliation: Shanghai Key Laboratory of New Drug Design, School of Pharmacy, and State Key Laboratory of Bioengineering Reactors, East China University of Science & Technology , 130 Meilong Road, Shanghai 200237, People's Republic of China.
authors.forename: Guangjun
authors.initials: G
authors.lastname: Song
authors.affiliation: Shanghai Key Laboratory of New Drug Design, School of Pharmacy, and State Key Laboratory of Bioengineering Reactors, East China University of Science & Technology , 130 Meilong Road, Shanghai 200237, People's Republic of China.
authors.forename: Ziwei
authors.initials: Z
authors.lastname: Zheng
authors.affiliation: Shanghai Key Laboratory of New Drug Design, School of Pharmacy, and State Key Laboratory of Bioengineering Reactors, East China University of Science & Technology , 130 Meilong Road, Shanghai 200237, People's Republic of China.
authors.forename: Yanhui
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Shanghai Key Laboratory of New Drug Design, School of Pharmacy, and State Key Laboratory of Bioengineering Reactors, East China University of Science & Technology , 130 Meilong Road, Shanghai 200237, People's Republic of China.
authors.forename: Xinhong
authors.initials: X
authors.lastname: Yu