title: JAK/STAT Signal Transduction: Promising Attractive Targets for Immune, Inflammatory and Hematopoietic Diseases.
abstract: JAK/STAT signal pathway, a requisite part in the signaling process of growth factors and cytokines, has become attractive targets for numerous immune, inflammatory and hematopoietic diseases.
  
  
  
  Herein, we present a review of the JAK/STAT signal pathway, the structure, biological function, mechanism of the JAKs and STATs along with a summary of the up-to-date clinical or approved JAK inhibitors which are involved in the treatment of various kinds of tumors and other immunity indications. Moreover, kinds of recently discovered JAKs inhibitors with potent activity or promising selectivity are also briefly discussed.
  
  
  
  Research and development of isoform selective JAK inhibitors has become a hot topic in this field. With the assistance of high throughput screening and rational drug design, more and more JAK inhibitors with improved selective profiles will be discovered as biological probes and even therapeutic agents.
authors.affiliation: Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, 44, West Wenhua Road, 250012, Jinan, Shandong, China.
authors.forename: Qianwen
authors.initials: Q
authors.lastname: Gao
authors.affiliation: Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, 44, West Wenhua Road, 250012, Jinan, Shandong, China.
authors.forename: Xuewu
authors.initials: X
authors.lastname: Liang
authors.affiliation: Institute of Clinical Pharmacology, Qilu Hospital of Shandong University, 44, West Wenhua Road, 250012, Jinan, Shandong, China.
authors.forename: Abdul Sami
authors.initials: AS
authors.lastname: Shaikh
authors.affiliation: Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, 44, West Wenhua Road, 250012, Jinan, Shandong, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zang
authors.affiliation: Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, 44, West Wenhua Road, 250012, Jinan, Shandong, China.
authors.forename: Wenfang
authors.initials: W
authors.lastname: Xu
authors.affiliation: Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, 44, West Wenhua Road, 250012, Jinan, Shandong, China.
authors.forename: Yingjie
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D006402:Hematologic Diseases / Q000188:drug therapy / Q000378:metabolism*; D006801:Humans; D007154:Immune System Diseases / Q000188:drug therapy / Q000378:metabolism*; D007249:Inflammation / Q000188:drug therapy / Q000378:metabolism*; D053612:Janus Kinases / Q000737:chemistry / Q000378:metabolism; D058990:Molecular Targeted Therapy; D047428:Protein Kinase Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D050791:STAT Transcription Factors / Q000737:chemistry / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects*
chemical_list: D047428:Protein Kinase Inhibitors; D050791:STAT Transcription Factors; D053612:Janus Kinases
keywords: Inflammation; JAK; STAT; kinase inhibitors; selectivity; signal transduction