title: Integration of Global Analyses of Host Molecular Responses with Clinical Data To Evaluate Pathogenesis and Advance Therapies for Emerging and Re-emerging Viral Infections.
abstract: Outbreaks associated with emerging and re-emerging viral pathogens continue to increase in frequency and are associated with an increasing burden to global health. In light of this, there is a need to integrate basic and clinical research for investigating the connections between molecular and clinical pathogenesis and for therapeutic development strategies. Here, we will discuss this approach with a focus on the emerging viral pathogens Middle East respiratory syndrome coronavirus (MERS-CoV), Ebola virus (EBOV), and monkeypox virus (MPXV) from the context of clinical presentation, immunological and molecular features of the diseases, and OMICS-based analyses of pathogenesis. Furthermore, we will highlight the role of global investigations of host kinases, the kinome, for investigating emerging and re-emerging viral pathogens from the context of characterizing cellular responses and identifying novel therapeutic targets. Lastly, we will address how increased integration of clinical and basic research will assist treatment and prevention efforts for emerging pathogens.
authors.affiliation: Critical Care Medicine Department, Clinical Center, National Institutes of Health , Bethesda, Maryland 20814, United States.
authors.forename: Shane D
authors.initials: SD
authors.lastname: Falcinelli
authors.affiliation: Critical Care Medicine Department, Clinical Center, National Institutes of Health , Bethesda, Maryland 20814, United States.
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Chertow
authors.affiliation: Critical Care Medicine Department, Clinical Center, National Institutes of Health , Bethesda, Maryland 20814, United States.
authors.forename: Jason
authors.initials: J
authors.lastname: Kindrachuk
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology; D006801:Humans; D014777:Virus Diseases / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism / Q000821:virology*; D018406:Virus Physiological Phenomena; D014780:Viruses / Q000187:drug effects / Q000235:genetics / Q000472:pathogenicity
chemical_list: D000998:Antiviral Agents
keywords: cell signaling; emerging pathogens; high-consequence pathogens; kinases; kinomics; virology