title: A Multifunctional Platform for Tumor Angiogenesis-Targeted Chemo-Thermal Therapy Using Polydopamine-Coated Gold Nanorods.
abstract: Image-guided combined chemo-thermal therapy assists in optimizing treatment time, enhancing therapeutic efficiency, and circumventing side effects. In the present study, we developed a chemo-photothermal theranostic platform based on polydopamine (PDA)-coated gold nanorods (GNRs). The PDA coating was thin; however, it significantly suppressed the cytotoxicity of the cetyltrimethylammonium bromide template and allowed high cisplatin loading efficiency, arginine-glycine-aspartic acid (RGD) peptide (c(RGDyC)) conjugation, and chelator-free iodine-125 labeling (RGD-125IPt-PDA@GNRs). While loaded cisplatin was released in a pH-sensitive manner, labeled125I was outstandingly stable under biological conditions. RGD-125IPt-PDA@GNRs had a high specificity for αvβ3integrin, and consequently, they could selectively accumulate in tumors, as revealed by single photon emission computed tomography/CT imaging, and in target tumor angiogenic vessels, as shown by high-resolution photoacoustic imaging. As RGD-125IPt-PDA@GNRs targets tumor angiogenesis, it is a highly potent tumor therapy. Combined chemo-photothermal therapy with probes could thoroughly ablate tumors and inhibit tumor relapse via a synergistic antitumor effect. Our studies demonstrated that RGD-125IPt-PDA@GNRs is a robust platform for image-guided, chemo-thermal tumor therapy with outstanding synergistic tumor killing and relapse inhibition effects.
authors.affiliation: State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, School of Biomedical Engineering, Shanghai Jiao Tong University , Shanghai 200030, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Zhang
authors.forename: Huilan
authors.initials: H
authors.lastname: Su
authors.affiliation: Changzheng Hospital, Secondary Military Medical University , Shanghai 200003, China.
authors.forename: Jiali
authors.initials: J
authors.lastname: Cai
authors.forename: Dengfeng
authors.initials: D
authors.lastname: Cheng
authors.forename: Yongjie
authors.initials: Y
authors.lastname: Ma
authors.forename: Jianping
authors.initials: J
authors.lastname: Zhang
authors.forename: Chuanqing
authors.initials: C
authors.lastname: Zhou
authors.affiliation: Changzheng Hospital, Secondary Military Medical University , Shanghai 200003, China.
authors.forename: Shiyuan
authors.initials: S
authors.lastname: Liu
authors.forename: Hongcheng
authors.initials: H
authors.lastname: Shi
authors.forename: Yingjian
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, School of Biomedical Engineering, Shanghai Jiao Tong University , Shanghai 200030, China.|Department of Nuclear Medicine, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University , Shanghai 200025, China.
authors.forename: Chunfu
authors.initials: C
authors.lastname: Zhang
mesh_terms: D004317:Doxorubicin; D006046:Gold; D007211:Indoles; D007457:Iodine Radioisotopes; D043942:Nanotubes; D009369:Neoplasms / Q000188:drug therapy; D009389:Neovascularization, Pathologic / Q000188:drug therapy*; D011108:Polymers
chemical_list: D007211:Indoles; D007457:Iodine Radioisotopes; D011108:Polymers; C568283:polydopamine; D006046:Gold; D004317:Doxorubicin; C000614960:Iodine-125
keywords: angiogenesis targeted; chemo-photothermal combined therapy; cisplatin; gold nanorods; image-guided; photoacoustic imaging; polydopamine