title: Cytotoxic Homoisoflavonoids from Ophiopogon japonicus Tubers.
abstract: A phytochemical fractionation of a methanol extract of Ophiopogon japonicus tubers led to the isolation of a new homoisoflavanone, homoisopogon A (1), and three new homoisoflavanes, homoisopogon B-D (2-4). Their chemical structures were elucidated by mass, NMR, and circular dichroism (CD) spectroscopic methods. Homoisopogon A (1) exhibited potent cytotoxicity against human lung adenocarcinoma LU-1, human epidermoid carcinoma KB, and human melanoma SK-Mel-2 cancer cells with IC50values ranging from 0.51 to 0.66 µM.
authors.affiliation: Advanced Center for Bio-organic Chemistry, Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST).
authors.forename: Nguyen Hai
authors.initials: NH
authors.lastname: Dang
authors.forename: Nguyen Dinh
authors.initials: ND
authors.lastname: Chung
authors.forename: Ha Manh
authors.initials: HM
authors.lastname: Tuan
authors.forename: Nguyen Tuan
authors.initials: NT
authors.lastname: Hiep
authors.forename: Nguyen Tien
authors.initials: NT
authors.lastname: Dat
mesh_terms: D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D031441:Ophiopogon / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D035281:Plant Tubers / Q000737:chemistry*
chemical_list: D007529:Isoflavones; D010936:Plant Extracts