title: HIV prevalence and phylogenetic characteristics among entry travelers in Xishuangbanna prefecture, Yunnan province, between 2003 and 2012.
abstract: Xishuangbanna is a popular tourist destination in southern Yunnan Province, bordering with Vietnam and Laos, and Myanmar. There are more than 2 million cross-border travelers annually entering China at two land ports, Daluo and Mohan. To clarify the characteristics of HIV-1 prevalence among entry travelers, a retrospective epidemic investigation was conducted. Between 2003 and 2012, 196 among 91 432 entry travelers were detected to be HIV-1-positive, accounting for infection rate of 0.21%. Eighty-one gag-pol gene sequences were obtained for phylogenetic analyses and subsequent recombination analysis. It was shown that the most prevalent HIV-1 subtype in this population was circulating recombinant form (CRF) 01_AE (42, 51.86%), followed by CRF08_BC (17, 20.99%), CRF07_BC (4, 4.94%), B' (2, 2.47%), C (2, 2.47%), other recombinants (9, 11.11%), and undefined subtype (5, 6.17%). HIV-1 genotype distribution among travelers entering at two land ports is different, CRF01_AE and CRF08_BC accounted for a larger percentage among individuals from Daluo, whereas the proportions of subtype C and undefined URFs were larger among individuals from Mohan. The undefined subtype indicates the occurrence of novel HIV-1 subtype or CRF. This finding is useful for developing of AIDS prevention strategies.
authors.affiliation: Faculty of Life Science and Technology, Center for Molecular medicine in Yunnan province, Kunming University of Science and Technology, Kunming, Yunnan, China.
authors.forename: Binghui
authors.initials: B
authors.lastname: Wang
authors.affiliation: Care Center for International Travel Health in Yunnan, Yunnan, China.
authors.forename: Yuebo
authors.initials: Y
authors.lastname: Liang
authors.affiliation: Faculty of Life Science and Technology, Center for Molecular medicine in Yunnan province, Kunming University of Science and Technology, Kunming, Yunnan, China.
authors.forename: Yajuan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Faculty of Life Science and Technology, Center for Molecular medicine in Yunnan province, Kunming University of Science and Technology, Kunming, Yunnan, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Feng
authors.affiliation: Care Center for International Travel Health in Yunnan, Yunnan, China.
authors.forename: Yaping
authors.initials: Y
authors.lastname: Li
authors.affiliation: Faculty of Life Science and Technology, Center for Molecular medicine in Yunnan province, Kunming University of Science and Technology, Kunming, Yunnan, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Faculty of Life Science and Technology, Center for Molecular medicine in Yunnan province, Kunming University of Science and Technology, Kunming, Yunnan, China.
authors.forename: Qicai
authors.initials: Q
authors.lastname: Xuan
authors.affiliation: Faculty of Life Science and Technology, Center for Molecular medicine in Yunnan province, Kunming University of Science and Technology, Kunming, Yunnan, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Miao
authors.affiliation: Care Center for International Travel Health in Yunnan, Yunnan, China.
authors.forename: Weihong
authors.initials: W
authors.lastname: Qin
authors.affiliation: Faculty of Life Science and Technology, Center for Molecular medicine in Yunnan province, Kunming University of Science and Technology, Kunming, Yunnan, China.
authors.forename: Xueshan
authors.initials: X
authors.lastname: Xia
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002681:China / Q000453:epidemiology; D016000:Cluster Analysis; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000453:epidemiology* / Q000821:virology*; D015497:HIV-1 / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010802:Phylogeny; D015995:Prevalence; D012189:Retrospective Studies; D017422:Sequence Analysis, DNA; D014195:Travel; D055815:Young Adult; D054301:gag Gene Products, Human Immunodeficiency Virus / Q000235:genetics; D054302:pol Gene Products, Human Immunodeficiency Virus / Q000235:genetics
chemical_list: D054301:gag Gene Products, Human Immunodeficiency Virus; D054302:pol Gene Products, Human Immunodeficiency Virus
keywords: epidemiology; genetics; human immunodeficiency virus; infection; virus classification