title: [Effect of self-expanding bare metal stents of different diameters on the trachea of dogs].
abstract: Objective:To study the effect of self-expanding bare metal stents on the trachea of dogs, and therefore to provide useful information for choice of airway stents by interventional physicians.Methods:In this experiment, 8 beagles were randomly divided into 4 groups. Four self-expanding metal stents of different diameters (16, 18, 20 and 22 mm, respectively) were placed in the trachea of these beagles for 3 months and their impacts on normal trachea were observed.Results:In the 16 mm stent group (stent-to-airway diameter ratio 103%), good epithelialization was observed and the tracheal structure had no significant damage. In the 18 mm stent group (stent-to-airway diameter ratio 116%), slight granulation tissues were observed, but the cartilage and outer membrane were normal. In the 20 mm stent group (stent-to-airway diameter ratio 129%), severe granulation tissues were observed. Cartilage was damaged but outer membrane was normal. In the 22 mm stent group (stent-to-airway diameter ratio 142%), no obvious granulation tissues were found. Cartilage was normal, but outer membrane was ruptured.Conclusion:In a certain range, tracheal granulation tissues increased as the stent diameter increased. However, if the stent diameter continued to increase, a decreasing trend of tracheal granulation was observed, but severe tracheal injury by stent expansion force would occur.
authors.affiliation: Department of Respiratory, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China.
authors.forename: T
authors.initials: T
authors.lastname: Wang
authors.forename: J
authors.initials: J
authors.lastname: Zhang
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.forename: Y H
authors.initials: YH
authors.lastname: Pei
authors.forename: X J
authors.initials: XJ
authors.lastname: Qiu
authors.forename: Y L
authors.initials: YL
authors.lastname: Wang
mesh_terms: D000818:Animals; D004285:Dogs; D006097:Granulation Tissue / Q000473:pathology*; D008670:Metals; D011897:Random Allocation; D000069322:Self Expandable Metallic Stents / Q000662:veterinary*; D015607:Stents; D014132:Trachea / Q000473:pathology*; D014133:Tracheal Diseases; D014135:Tracheal Stenosis / Q000628:therapy* / Q000662:veterinary
chemical_list: D008670:Metals