title: Associations between maternal BMI as well as glucose tolerance and adverse pregnancy outcomes in women with polycystic ovary syndrome.
abstract: This retrospective, cohort study examined the association between maternal pre-pregnancy body mass index (BMI), independent of glucose tolerance and adverse pregnancy outcomes in women with polycystic ovary syndrome (PCOS), for which there are few previous studies. Medical records from 2012 to 2015 at Guangzhou Women and Children's Medical Center, China were reviewed for women previously diagnosed with PCOS with normal 2-h 75-g oral glucose tolerance test (OGTT) results (n = 1249). The separate and joint effects of maternal BMI and glucose levels on pregnancy outcomes were assessed. Maternal pre-pregnancy BMI was associated with hypertensive disorders of pregnancy (HDP) (OR: 1.22, 95% CI: 1.02-1.45), preterm birth (OR: 1.49, 95% CI: 1.08-2.17), and large for gestational age (LGA) (OR: 1.69, 95% CI: 1.16-2.20). Elevated fasting glucose and maternal pre-pregnancy BMI were jointly associated with increased risks of HDP, preterm birth, and LGA. Therefore, among women with PCOS and normal glucose tolerance, maternal pre-pregnancy BMI is an independent risk factor of adverse pregnancy outcomes.
authors.affiliation: a Department of Obstetrics and Gynecology , Guangzhou Women and Children's Medical Center, Guangzhou Medical University , Guangzhou , China.
authors.forename: Ying-Ying
authors.initials: YY
authors.lastname: Li
authors.affiliation: a Department of Obstetrics and Gynecology , Guangzhou Women and Children's Medical Center, Guangzhou Medical University , Guangzhou , China.
authors.forename: Su-Qi
authors.initials: SQ
authors.lastname: Ye
authors.affiliation: a Department of Obstetrics and Gynecology , Guangzhou Women and Children's Medical Center, Guangzhou Medical University , Guangzhou , China.
authors.forename: Zhuo-Hui
authors.initials: ZH
authors.lastname: Zhong
authors.affiliation: a Department of Obstetrics and Gynecology , Guangzhou Women and Children's Medical Center, Guangzhou Medical University , Guangzhou , China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Xu
authors.affiliation: a Department of Obstetrics and Gynecology , Guangzhou Women and Children's Medical Center, Guangzhou Medical University , Guangzhou , China.
authors.forename: Wei-Bi
authors.initials: WB
authors.lastname: Mai
authors.affiliation: a Department of Obstetrics and Gynecology , Guangzhou Women and Children's Medical Center, Guangzhou Medical University , Guangzhou , China.
authors.forename: Cai-Xin
authors.initials: CX
authors.lastname: Yin
authors.affiliation: a Department of Obstetrics and Gynecology , Guangzhou Women and Children's Medical Center, Guangzhou Medical University , Guangzhou , China.
authors.forename: Zhi-Qin
authors.initials: ZQ
authors.lastname: Zhu
authors.affiliation: a Department of Obstetrics and Gynecology , Guangzhou Women and Children's Medical Center, Guangzhou Medical University , Guangzhou , China.
authors.forename: Xiao-Qian
authors.initials: XQ
authors.lastname: He
authors.affiliation: a Department of Obstetrics and Gynecology , Guangzhou Women and Children's Medical Center, Guangzhou Medical University , Guangzhou , China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Xiao
mesh_terms: D000328:Adult; D015992:Body Mass Index; D005260:Female; D018149:Glucose Intolerance / Q000097:blood / Q000150:complications*; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000209:etiology; D007231:Infant, Newborn; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications*; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D012307:Risk Factors
keywords: Body mass index; glucose tolerance; polycystic ovary syndrome; pregnancy outcomes