title: Low-dimensional compounds containing bioactive ligands. Part VIII: DNA interaction, antimicrobial and antitumor activities of ionic 5,7-dihalo-8-quinolinolato palladium(II) complexes with K+and Cs+cations.
abstract: Starting from well-defined NH2(CH3)2[PdCl2(XQ)] complexes, coordination compounds of general formula Cat[PdCl2(XQ)] have been prepared by cationic exchange of NH2(CH3)2+and Cat cations, where XQ are biologically active halogen derivatives of quinolin-8-ol (5-chloro-7-iodo-quinolin-8-ol (CQ), 5,7-dibromo-quinolin-8-ol (dBrQ) and 5,7-dichloro-quinolin-8-ol (dClQ)) and Cat is K+or Cs+. The cation exchange of all prepared complexes, K[PdCl2(CQ)] (1), K[PdCl2(dClQ)] (2), K[PdCl2(dBrQ)] (3), Cs[PdCl2(CQ)] (4), Cs[PdCl2(dClQ)] (5) and Cs[PdCl2(dBrQ)] (6) was approved using IR spectroscopy, their structures in DMSO solution were elucidated by one- and two-dimensional NMR experiments, whereas their stability in solution was verified by UV-VIS spectroscopy. Interaction of complexes to ctDNA was investigated using UV-VIS and fluorescence emission spectroscopy. The minimum inhibitory concentration and the minimum microbicidal concentration values were detected against 15 bacterial strains and 4 yeast strains to examine the antimicrobial activity for the complexes. The in vitro antitumor properties of the complexes were studied by testing the complexes on leukemic cell line L1210, ovarian cancer cell line A2780 and non-cancerous cell line HEK293. The majority of the prepared compounds exhibited moderate antimicrobial and very high cytotoxic activity.
authors.affiliation: Department of Inorganic Chemistry, Institute of Chemistry, P. J. Šafárik University, Moyzesova 11, 041 54 Košice, Slovakia.
authors.forename: Veronika
authors.initials: V
authors.lastname: Farkasová
authors.affiliation: Department of Inorganic Chemistry, National Research Center, P.O. 12622, 33 Elbohoth St. (former Elthrirst), Dokki, Giza, Egypt.
authors.forename: Sayed Ali
authors.initials: SA
authors.lastname: Drweesh
authors.affiliation: Department of Inorganic Chemistry, Institute of Chemistry, P. J. Šafárik University, Moyzesova 11, 041 54 Košice, Slovakia.
authors.forename: Andrea
authors.initials: A
authors.lastname: Lüköová
authors.affiliation: Department of Biochemistry, Institute of Chemistry, P.J. Šafárik University, Moyzesova 11, 041 54 Košice, Slovakia.
authors.forename: Danica
authors.initials: D
authors.lastname: Sabolová
authors.affiliation: Department of Biology and Ecology, Faculty of Science, University of Kragujevac, R. Domanovića 12, 34000 Kragujevac, Serbia.
authors.forename: Ivana D
authors.initials: ID
authors.lastname: Radojević
authors.affiliation: Department of Biology and Ecology, Faculty of Science, University of Kragujevac, R. Domanovića 12, 34000 Kragujevac, Serbia.
authors.forename: Ljiljana R
authors.initials: LR
authors.lastname: Čomić
authors.affiliation: Department of Biology and Ecology, Faculty of Science, University of Kragujevac, R. Domanovića 12, 34000 Kragujevac, Serbia.
authors.forename: Sava M
authors.initials: SM
authors.lastname: Vasić
authors.affiliation: Department of Biochemistry and Microbiology, Faculty of Chemical and Food Technology, Slovak University of Technology, Radlinského 9, 812 37 Bratislava, Slovakia.
authors.forename: Helena
authors.initials: H
authors.lastname: Paulíková
authors.affiliation: Department of Biochemistry and Microbiology, Faculty of Chemical and Food Technology, Slovak University of Technology, Radlinského 9, 812 37 Bratislava, Slovakia.
authors.forename: Stanislav
authors.initials: S
authors.lastname: Fečko
authors.affiliation: Department of Biochemistry and Microbiology, Faculty of Chemical and Food Technology, Slovak University of Technology, Radlinského 9, 812 37 Bratislava, Slovakia.
authors.forename: Tatiana
authors.initials: T
authors.lastname: Balašková
authors.affiliation: NMR Laboratory, Institute of Chemistry, P.J. Šafárik University, Moyzesova 11, 041 54 Košice, Slovakia.
authors.forename: Mária
authors.initials: M
authors.lastname: Vilková
authors.affiliation: NMR Laboratory, Institute of Chemistry, P.J. Šafárik University, Moyzesova 11, 041 54 Košice, Slovakia.
authors.forename: Ján
authors.initials: J
authors.lastname: Imrich
authors.affiliation: Department of Inorganic Chemistry, Institute of Chemistry, P. J. Šafárik University, Moyzesova 11, 041 54 Košice, Slovakia. Electronic address: ivan.potocnak@upjs.sk.
authors.forename: Ivan
authors.initials: I
authors.lastname: Potočňák
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry; D001419:Bacteria / Q000254:growth & development*; D045744:Cell Line, Tumor; D002586:Cesium / Q000737:chemistry / Q000494:pharmacology; D056831:Coordination Complexes / Q000737:chemistry / Q000494:pharmacology; D004247:DNA / Q000737:chemistry; D004354:Drug Screening Assays, Antitumor; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D010165:Palladium / Q000737:chemistry / Q000494:pharmacology; D011188:Potassium / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D056831:Coordination Complexes; D002586:Cesium; D010165:Palladium; D004247:DNA; C427203:calf thymus DNA; D011188:Potassium
keywords: Antimicrobial; Antitumor; DNA binding; Pd(II) complexes; Quinolin-8-ol derivatives