title: Walking Pace and the Risk of Cognitive Decline and Dementia in Elderly Populations: A Meta-analysis of Prospective Cohort Studies.
abstract: Data on the longitudinal association of walking pace with the risk of cognitive decline and dementia are inconsistent and inconclusive. Therefore, researchers conducted a meta-analysis of prospective cohort studies to quantitatively assess the association of walking pace with the risk of cognitive decline and dementia among elderly populations.
  
  
  
  Eligible studies were searched in PubMed and EMBASE through April 22, 2016. Additional information was retrieved through Google Scholar or hand review of the reference lists from the relevant studies. Prospective cohort studies were included if they reported relative risk (RR) and the corresponding 95% confidence interval (CI) of cognitive decline or dementia in relation to walking pace.
  
  
  
  Seventeen studies were identified, including 10 studies reporting the RR of cognitive decline (9,949 participants and 2,547 events) and 10 presenting the RR of dementia (14,140 participants and 1,903 events). Comparing the lowest to the highest category of walking pace, the pooled RR was 1.89 (95% CI = 1.54-2.31) for cognitive decline and 1.66 (95% CI = 1.43-1.92) for dementia. With every 1 dm/s (360 m/h) decrement in walking pace, the risk of dementia was increased by 13% (RR = 1.13; 95% CI = 1.08-1.18).
  
  
  
  This meta-analysis provides accumulated evidence supporting that slow or decreased walking pace is significantly associated with elevated risk of cognitive decline and dementia in elderly populations.
authors.affiliation: Department of Sport Rehabilitation, School of Kinesiology, Shanghai University of Sport, Shanghai, China.|Department of Epidemiology and Biostatistics, School of Public Health-Bloomington, Indiana University.
authors.forename: Minghui
authors.initials: M
authors.lastname: Quan
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health-Bloomington, Indiana University.
authors.forename: Pengcheng
authors.initials: P
authors.lastname: Xun
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health-Bloomington, Indiana University.
authors.forename: Cheng
authors.initials: C
authors.lastname: Chen
authors.affiliation: Department of Sport Rehabilitation, School of Kinesiology, Shanghai University of Sport, Shanghai, China.
authors.forename: Ju
authors.initials: J
authors.lastname: Wen
authors.affiliation: Department of Kinesiology and Nutrition, College of Applied Health Science, University of Illinois at Chicago.
authors.forename: Yiyu
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Sport Rehabilitation, School of Kinesiology, Shanghai University of Sport, Shanghai, China.
authors.forename: Ru
authors.initials: R
authors.lastname: Wang
authors.affiliation: Department of Sport Rehabilitation, School of Kinesiology, Shanghai University of Sport, Shanghai, China. chenpeijie@sus.edu.cn kahe@indiana.edu.
authors.forename: Peijie
authors.initials: P
authors.lastname: Chen
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health-Bloomington, Indiana University.
authors.forename: Ka
authors.initials: K
authors.lastname: He
mesh_terms: D000368:Aged; D060825:Cognitive Dysfunction / Q000453:epidemiology* / Q000209:etiology; D015331:Cohort Studies; D003704:Dementia / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D011446:Prospective Studies; D018570:Risk Assessment; D000072797:Walking Speed
keywords: Cognitive decline; Dementia; Walking pace; “Meta-analysis”