title: Haloperidol increases false recognition memory of thematically related pictures in healthy volunteers.
abstract: Dopamine can modulate long-term episodic memory. Its potential role on the generation of false memories, however, is less well known. In a randomized, double-blind, placebo-controlled experiment, 24 young healthy volunteers ingested a 4-mg oral dose of haloperidol, a dopamine D2-receptor antagonist, or placebo, before taking part in a recognition memory task. Haloperidol was active during both study and test phases of the experiment. Participants in the haloperidol group produced more false recognition responses than those in the placebo group, despite similar levels of correct recognition. These findings show that dopamine blockade in healthy volunteers can specifically increase false recognition memory.
authors.affiliation: Department of Psychobiology, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors.forename: Regina V
authors.initials: RV
authors.lastname: Guarnieri
authors.affiliation: Department of Basic Psychological Processes, Institute of Psychology, Universidade de Brasília, Brasilia, DF, Brazil.
authors.forename: Luciano G
authors.initials: LG
authors.lastname: Buratto
authors.affiliation: Department of Human Development, Cornell University, Ithaca, New York, USA.
authors.forename: Carlos F A
authors.initials: CF
authors.lastname: Gomes
authors.affiliation: Department of Psychobiology, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors.forename: Rafaela L
authors.initials: RL
authors.lastname: Ribeiro
authors.affiliation: Department of Psychobiology, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors.forename: Altay A Lino
authors.initials: AA
authors.lastname: de Souza
authors.affiliation: Postgraduate Program in Psychology (Human Cognition), Department of Psychology, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Lilian M
authors.initials: LM
authors.lastname: Stein
authors.affiliation: Department of Psychobiology, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors.forename: José C
authors.initials: JC
authors.lastname: Galduróz
authors.affiliation: Department of Psychobiology, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors.forename: Orlando F A
authors.initials: OF
authors.lastname: Bueno
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000494:pharmacology; D018492:Dopamine Antagonists / Q000494:pharmacology*; D004311:Double-Blind Method; D005260:Female; D006220:Haloperidol / Q000494:pharmacology*; D064368:Healthy Volunteers / Q000523:psychology; D006801:Humans; D008297:Male; D008568:Memory / Q000187:drug effects* / Q000502:physiology; D010775:Photic Stimulation / Q000379:methods*; D021641:Recognition, Psychology / Q000187:drug effects* / Q000502:physiology; D012094:Repression, Psychology; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D018492:Dopamine Antagonists; D006220:Haloperidol
keywords: dopamine; false memory; haloperidol; recognition memory