title: The importance of nucleoside hydrolase enzyme (NH) in studies to treatment of Leishmania: A review.
abstract: Leishmania is a genus of trypanosomes, which are responsible for leishmaniasis disease, a major trypanosome infection in humans. In recent years, published studies have shown that the search for new drugs for Leishmania treatments has intensified. Through technique modeling it has been possible to develop new compounds, which act as nucleoside hydrolase (NH) inhibitors. The effect of these enzymes is the hydrolysis of certain RNA nucleotides, which include uridine and inosine, necessary for the protozoa to transform certain nucleosides obtained from infected individuals into nucleobases for the preparation of their DNA. The obtention of NH inhibitors is very important to eliminate leishmaniasis disease in infected individuals. The aim of this study is to discuss the research and development of new agents for the treatment of Leishmania, and to stimulate the formulation of new NH inhibitors.
authors.affiliation: Medicinal Chemistry Group, Department of Chemistry, Military Institute of Engineering, Praça General Tibúrcio 80, 22290-270 Rio de Janeiro, Brazil. Electronic address: jdfv2009@gmail.com.
authors.forename: José D
authors.initials: JD
authors.lastname: Figueroa-Villar
authors.affiliation: Medicinal Chemistry Group, Department of Chemistry, Military Institute of Engineering, Praça General Tibúrcio 80, 22290-270 Rio de Janeiro, Brazil.
authors.forename: Edijane M
authors.initials: EM
authors.lastname: Sales
mesh_terms: D000818:Animals; D020134:Catalytic Domain; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D007891:Leishmania / Q000201:enzymology*; D007896:Leishmaniasis / Q000188:drug therapy / Q000469:parasitology; D008968:Molecular Conformation; D062105:Molecular Docking Simulation; D009699:N-Glycosyl Hydrolases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D015800:Protozoan Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D012255:Ribitol / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism
chemical_list: D004791:Enzyme Inhibitors; D015800:Protozoan Proteins; C089322:phenyliminoribitol; D012255:Ribitol; D009699:N-Glycosyl Hydrolases
keywords: Enzyme inhibition; Leishmania; Molecular docking; NMR and UV test; Nucleoside hydrolases