title: ABCB1 genotyping in the treatment of depression.
abstract: P-glycoprotein (P-gp), the gene product of ABCB1, is a drug transporter at the blood-brain barrier and could be a limiting factor for entrance of antidepressants into the brain, the target site of antidepressant action. Animal studies showed that brain concentrations of many antidepressants depend on P-gp. In humans, ABCB1 genotyping in the treatment of depression rests on the assumption that genetic variations in ABCB1 explain individual differences in antidepressant response via their effects on P-gp expression at the blood-brain barrier. High P-gp expression is hypothesized to lead to lower and often insufficient brain concentrations of P-gp substrate antidepressants. In this review, we summarize 32 studies investigating the question of whether ABCB1 polymorphisms predict clinical efficacy and/or tolerability of antidepressants in humans and evaluate the clinical application status of ABCB1 genotyping in depression treatment.
authors.affiliation: Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Kraepelinstr. 2-10, 80804 Munich, Germany.
authors.forename: Tanja Maria
authors.initials: TM
authors.lastname: Brückl
authors.affiliation: Clinical Laboratory, Max Planck Institute of Psychiatry, Kraepelinstr. 2-10, 80804 Munich, Germany.
authors.forename: Manfred
authors.initials: M
authors.lastname: Uhr
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics*; D001812:Blood-Brain Barrier; D003863:Depression / Q000188:drug therapy* / Q000235:genetics; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1
keywords: ABCB1 genotyping; P-gp; antidepressant response; antidepressant side effects; antidepressants; blood–brain barrier; gene; major depression; multidrug resistance; pharmacogenetic test; pharmacokinetic gene