title: Regional homogeneity associated with overgeneral autobiographical memory of first-episode treatment-naive patients with major depressive disorder in the orbitofrontal cortex: A resting-state fMRI study.
abstract: Overgeneral autobiographical memory (OGM) is involved in the onset and maintenance of depression. Recent studies have shown correlations between OGM and alterations of some brain regions by using task-state functional magnetic resonance imaging (fMRI). However, the correlation between OGM and spontaneous brain activity in depression remains unclear. The purpose of this study was to determine whether patients with major depressive disorder (MDD) show abnormal regional homogeneity (ReHo) and, if so, whether the brain areas with abnormal ReHo are associated with OGM.
  
  
  
  Twenty five patients with MDD and 25 age-matched, sex-matched, and education-matched healthy controls underwent resting-state fMRI. All participants were also assessed by 17-item Hamilton Depression Rating Scale and autobiographical memory test. The ReHo method was used to analyze regional synchronization of spontaneous neuronal activity.
  
  
  
  Patients with MDD, compared to healthy controls, exhibited extensive ReHo abnormalities in some brain regions, including the frontal, temporal, and occipital cortex. Moreover, ReHo value of the orbitofrontal cortex was negatively correlated with OGM scores in patients with MDD.
  
  
  
  The sample size of this study was relatively small, and the influence of physiological noise was not completely excluded.
  
  
  
  These results suggest that abnormal ReHo of spontaneous brain activity in the orbitofrontal cortex may be involved in the pathophysiology of OGM in patients with MDD.
authors.affiliation: Department of Psychosomatic Medicine, Wuxi Mental Health Center, Nanjing Medical University, Wuxi 214151, Jiangsu Province, China; Department of Psychosomatic Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200092, China. Electronic address: lysway@126.com.
authors.forename: Yansong
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Psychosomatic Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200092, China.
authors.forename: Xudong
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of Psychosomatic Medicine, Wuxi Mental Health Center, Nanjing Medical University, Wuxi 214151, Jiangsu Province, China.
authors.forename: Zaohuo
authors.initials: Z
authors.lastname: Cheng
authors.affiliation: Department of Psychosomatic Medicine, Wuxi Mental Health Center, Nanjing Medical University, Wuxi 214151, Jiangsu Province, China.
authors.forename: Fuquan
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Department of Medical Imaging, Wuxi Third People's Hospital, Wuxi 214041, Jiangsu Province, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Chang
authors.affiliation: Department of Science and Education, The Fourth People's Hospital, Taizhou 225300, Jiangsu Province, China.
authors.forename: Haosen
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Medical Imaging, Wuxi Third People's Hospital, Wuxi 214041, Jiangsu Province, China.
authors.forename: Rukui
authors.initials: R
authors.lastname: Xie
authors.affiliation: Department of Psychosomatic Medicine, Wuxi Mental Health Center, Nanjing Medical University, Wuxi 214151, Jiangsu Province, China.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Psychosomatic Medicine, Wuxi Mental Health Center, Nanjing Medical University, Wuxi 214151, Jiangsu Province, China.
authors.forename: Leiming
authors.initials: L
authors.lastname: Cao
authors.affiliation: Department of Psychosomatic Medicine, Wuxi Mental Health Center, Nanjing Medical University, Wuxi 214151, Jiangsu Province, China. Electronic address: wangguoqiaxmhc@163.com.
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Wang
mesh_terms: D000328:Adult; D001931:Brain Mapping / Q000379:methods; D003865:Major Depressive Disorder / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000523:psychology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D061212:Memory, Episodic; D008875:Middle Aged; D009483:Neuropsychological Tests; D017397:Prefrontal Cortex / Q000000981:diagnostic imaging* / Q000503:physiopathology; D055815:Young Adult