title: The Value of 99mTc ECD SPECT With Statistical Image Analysis on Enhancing the Early Diagnosis of Primary Progressive Aphasia.
abstract: A 64-year-old woman with poor short-term memory was first suspected as early Alzheimer disease. Tc ECD brain SPECT was arranged for differential diagnosis. A small area of mild hypoperfusion was noted in the left temporal lobe on conventional display. Further statistical analysis of SPECT with an easy Z-score imaging system showed large areas of distinct hypoperfusion in left precentral and perisylvian cortical areas, compatible with typical pictures of nonfluent variant primary progressive aphasia (PPA), but no involvement in areas characteristic for Alzheimer disease. Further detailed neuropsychological examination and 6 months of clinical follow-up confirmed the final diagnosis of PPA.
authors.affiliation: From the *Department of Neurology, Chang Bing Show Chwan Memorial Hospital, Changhua; †Department of Exercise and Health Promotion, College of Education, Chinese Culture University, Taipei; ‡Department of Neurology, Show Chwan Memorial Hospital, Changhua; §Institute of Medicine, Chung Shan Medical University, Taichung; ∥Department of Nuclear Medicine, Chang Bing Show Chwan Memorial Hospital, Changhua, Taiwan, Republic of China; ¶Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, Tokyo, Japan; and **Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan, Republic of China.
authors.forename: Cheng-Yu
authors.initials: CY
authors.lastname: Wei
authors.forename: Pai-Yi
authors.initials: PY
authors.lastname: Chiu
authors.forename: Po-Nien
authors.initials: PN
authors.lastname: Hou
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Matsuda
authors.forename: Guang-Uei
authors.initials: GU
authors.lastname: Hung
mesh_terms: D000368:Aged; D018888:Aphasia, Primary Progressive / Q000000981:diagnostic imaging*; D003545:Cysteine / Q000031:analogs & derivatives*; D003627:Data Interpretation, Statistical; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D008875:Middle Aged; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C059659:technetium Tc 99m bicisate; D003545:Cysteine