title: Prognostic Significance of Inflammatory and Nutritional Parameters in Patients with Esophageal Cancer.
abstract: We evaluated the following preoperative prognostic factors in patients who underwent esophagectomy for esophageal cancer: C-Reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), serum albumin, prognostic nutritional index (PNI), and body mass index (BMI).
  
  
  
  This retrospective study included 173 men and 19 women with a mean age of 65.8 years (range=42-86 years) who were scheduled to undergo esophagectomy for esophageal cancer. The association of CRP, NLR, albumin, PNI, and BMI with various clinicopathological factors and prognosis were evaluated.
  
  
  
  Univariate analysis revealed that male sex, depth of invasion, nodal metastasis, pStage, high CRP, low PNI, high NLR, and low BMI were significant risk factors for a poor prognosis. Multivariate analysis identified depth of invasion, pStage, and BMI as significant prognostic factors in the Cox proportional hazard model.
  
  
  
  The preoperative nutritional status affected the postoperative survival time in patients with esophageal cancer. In particular, a low BMI was an independent prognostic factor for poorer survival in the multivariate analysis.
authors.affiliation: Department of General Surgical Science, Gunma University Graduate School of Medicine, Gunma University, Gunma, Japan tatsuyamiyazaki@gunma-u.ac.jp.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Miyazaki
authors.affiliation: Department of General Surgical Science, Gunma University Graduate School of Medicine, Gunma University, Gunma, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Sakai
authors.affiliation: Department of General Surgical Science, Gunma University Graduate School of Medicine, Gunma University, Gunma, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Sohda
authors.affiliation: Department of General Surgical Science, Gunma University Graduate School of Medicine, Gunma University, Gunma, Japan.
authors.forename: Naritaka
authors.initials: N
authors.lastname: Tanaka
authors.affiliation: Department of Molecular Pharmacology and Oncology, Gunma University Graduate School of Medicine, Gunma University, Gunma, Japan.
authors.forename: Takehiko
authors.initials: T
authors.lastname: Yokobori
authors.affiliation: Department of Thoracic Visceral Organ Surgery, Gunma University Graduate School of Medicine, Gunma University, Gunma, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Motegi
authors.affiliation: First Department of Surgery, Dokkyo Medical University, Tochigi, Japan.
authors.forename: Masanobu
authors.initials: M
authors.lastname: Nakajima
authors.affiliation: Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Saitama, Japan.
authors.forename: Minoru
authors.initials: M
authors.lastname: Fukuchi
authors.affiliation: First Department of Surgery, Dokkyo Medical University, Tochigi, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kato
authors.affiliation: Department of General Surgical Science, Gunma University Graduate School of Medicine, Gunma University, Gunma, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kuwano
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004938:Esophageal Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D011379:Prognosis; D012189:Retrospective Studies
keywords: Prognostic nutritional index (PNI); body mass index (BMI); neutrophil-to-lymphocyte ratio (NLR)