title: Microfluidic Platform for the Continuous Production and Characterization of Multilamellar Vesicles: A Synchrotron Small-Angle X-ray Scattering (SAXS) Study.
abstract: A microfluidic platform combined with synchrotron small-angle X-ray scattering (SAXS) was used for monitoring the continuous production of multilamellar vesicles (MLVs). Their production was fast and started to evolve within less than 0.43 s of contact between the lipids and the aqueous phase. To obtain nanoparticles with a narrow size distribution, it was important to use a modified hydrodynamic flow focusing (HFF) microfluidic device with narrower microchannels than those normally used for SAXS experiments. Monodispersed MLVs as small as 160 nm in size, with a polydispersity index (PDI) of approximately 0.15 were achieved. The nanoparticles produced were smaller and had a narrower size distribution than those obtained via conventional bulk mixing methods. This microfluidic platform therefore has a great potential for the continuous production of monodispersed NPs.
authors.affiliation: Niels Bohr Institute, University of Copenhagen , Universitetsparken 5, DK-2100 Copenhagen Ø, Denmark.|Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen , Universitetsparken 2, DK-2100 Copenhagen Ø, Denmark.
authors.forename: Aghiad
authors.initials: A
authors.lastname: Ghazal
authors.affiliation: Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen , Universitetsparken 2, DK-2100 Copenhagen Ø, Denmark.
authors.forename: Mark
authors.initials: M
authors.lastname: Gontsarik
authors.affiliation: Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen , Universitetsparken 2, DK-2100 Copenhagen Ø, Denmark.
authors.forename: Jörg P
authors.initials: JP
authors.lastname: Kutter
authors.affiliation: Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen , Universitetsparken 2, DK-2100 Copenhagen Ø, Denmark.
authors.forename: Josiane P
authors.initials: JP
authors.lastname: Lafleur
authors.affiliation: Iran University of Medical Sciences , Shahid Hemmat Highway, Tehran, Iran.
authors.forename: Davoud
authors.initials: D
authors.lastname: Ahmadvand
authors.affiliation: MAX IV Laboratory, Lund University , 223 62 Lund, Sweden.
authors.forename: Ana
authors.initials: A
authors.lastname: Labrador
authors.affiliation: Laboratory for Biointerfaces, Empa, Swiss Federal Laboratories for Materials Science and Technology , Lerchenfeldstrasse 5, 9014 St. Gallen, Switzerland.
authors.forename: Stefan
authors.initials: S
authors.lastname: Salentinig
authors.affiliation: Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen , Universitetsparken 2, DK-2100 Copenhagen Ø, Denmark.
authors.forename: Anan
authors.identifier: http://orcid.org/0000-0003-1608-773X
authors.initials: A
authors.lastname: Yaghmur