title: Competition for Iron Between Host and Pathogen: A Structural Case Study on Helicobacter pylori.
abstract: Helicobacter pylori (H. pylori) is a highly successful bacterial pathogen, which colonizes the stomach of more than half of the world's population. To colonize and survive in such an acidic and inhospitable niche, H. pylori cells have evolved complex mechanisms to acquire nutrients from human hosts, including iron, an essential nutrient for both the pathogens and host cells. However, human cells also utilize diverse strategies in withholding of irons to prevent the bacterial outgrowth. The competition for iron is the central battlefield between pathogen and host. This mini-review summarizes the updated scenarios of the battle for iron between H. pylori and human host from a structural biology perspective.
authors.affiliation: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-sen University, 135 West Xingang Road, Guangzhou 510275, China. xiawei5@mail.sysu.edu.cn.
authors.forename: Wei
authors.initials: W
authors.lastname: Xia
mesh_terms: D000596:Amino Acids / Q000737:chemistry / Q000378:metabolism; D001665:Binding Sites; D001667:Binding, Competitive; D016481:Helicobacter Infections / Q000378:metabolism* / Q000382:microbiology*; D016480:Helicobacter pylori / Q000378:metabolism*; D006706:Homeostasis; D054884:Host-Pathogen Interactions; D006801:Humans; D007501:Iron / Q000737:chemistry / Q000378:metabolism*; D033862:Iron-Binding Proteins / Q000737:chemistry / Q000378:metabolism; D007781:Lactoferrin / Q000737:chemistry / Q000378:metabolism; D008958:Models, Molecular; D011485:Protein Binding; D011487:Protein Conformation
chemical_list: D000596:Amino Acids; D033862:Iron-Binding Proteins; D007501:Iron; D007781:Lactoferrin
keywords: Helicobacter pylori; Host–pathogen interactions; Iron-binding protein; Nutritional immunology