title: Adjunctive minocycline for schizophrenia: A meta-analysis of randomized controlled trials.
abstract: This study aimed to conduct a meta-analysis of the efficacy and safety of adjunctive minocycline for schizophrenia. Randomized controlled trials (RCTs) comparing adjunctive minocycline with placebo in patients with schizophrenia were included in the meta-analysis. Two independent investigators extracted and synthesized data. Standard mean differences (SMDs), risk ratio (RR) ±95% confidence intervals (CIs) and the number-needed-to-harm (NNH) were calculated. Eight RCTs with 548 schizophrenia patient including 286 (52.2%) patients on minocycline (171.9±31.2mg/day) and 262 (47.8%) on placebo completed 18.5±13.4 weeks of treatment. Meta-analyses of Positive and Negative Syndrome Scale (PANSS) (7 RCTs with 8 treatment arms)/Brief Psychiatric Rating Scale (BPRS) (1 RCT) total score [SMD: -0.64, (95%CI: -1.02, -0.27), P=0.0008; I2=74%], positive, negative and general symptom scores [SMD: -0.69 to -0.22 (95%CI: -0.98, -0.03), P=0.02-0.00001; I2=7-63%] revealed a significant superiority of adjunctive minocycline treatment over the placebo. There was no significant difference regarding neurocognitive function, discontinuation rate and adverse drug reactions between the two groups. This meta-analysis showed that adjunctive minocycline appears to be efficacious and safe for schizophrenia. Due to significant heterogeneity, future studies with a large sample size are needed to confirm these findings.
authors.affiliation: National Clinical Research Center for Mental Disorders, Beijing, China & Center of Depression, Beijing Institute for Brain Disorders, China; Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China.
authors.forename: Ying-Qiang
authors.initials: YQ
authors.lastname: Xiang
authors.affiliation: The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China. Electronic address: zhengwei0702@163.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Zheng
authors.affiliation: Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macao.
authors.forename: Shi-Bin
authors.initials: SB
authors.lastname: Wang
authors.affiliation: The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China.
authors.forename: Xin-Hu
authors.initials: XH
authors.lastname: Yang
authors.affiliation: Faculty of Traditional Chinese Medicine, the First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China.
authors.forename: Dong-Bin
authors.initials: DB
authors.lastname: Cai
authors.affiliation: Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia.
authors.forename: Chee H
authors.initials: CH
authors.lastname: Ng
authors.affiliation: The University of Notre Dame Australia/Marian Centre, Perth, Australia; School of Psychiatry & Clinical Neurosciences, University of Western Australia, Perth, Australia.
authors.forename: Gabor S
authors.initials: GS
authors.lastname: Ungvari
authors.affiliation: Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
authors.forename: Deanna L
authors.initials: DL
authors.lastname: Kelly
authors.affiliation: The Affiliated Hospital of JiangXi University of Traditional Chinese Medicine, Nanchang, China.
authors.forename: Wei-Ying
authors.initials: WY
authors.lastname: Xu
authors.affiliation: Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macao. Electronic address: xyutly@gmail.com.
authors.forename: Yu-Tao
authors.initials: YT
authors.lastname: Xiang
mesh_terms: D014150:Antipsychotic Agents / Q000627:therapeutic use*; D016206:Databases, Bibliographic / Q000706:statistics & numerical data; D006801:Humans; D008911:Minocycline / Q000627:therapeutic use*; D017063:Outcome Assessment, Health Care; D016032:Randomized Controlled Trials as Topic; D012559:Schizophrenia / Q000188:drug therapy*
chemical_list: D014150:Antipsychotic Agents; D008911:Minocycline
keywords: Antipsychotic; Meta-analysis; Minocycline; Schizophrenia