title: Store operated calcium entry: From concept to structural mechanisms.
abstract: In 1986, J.W. Putney presented a model for capacitative calcium (Ca2+) entry conveying that depletion of endoplasmic reticulum stored Ca2+levels leads to activation of plasma membrane Ca2+channels which mediate influx of Ca2+from the extracellular space into cells. Presently, the biomolecules regulating this process, more widely known as store operated Ca2+entry (SOCE) which is vital to myriad signaling pathways in health and disease, are known and the focus of intense structural biology research aiming to illuminate the atomic mechanisms of function. This brief review highlights the known structures with respect to the mechanisms of SOCE regulation and possible future directions in this field developed out of Putney's conceptualization of this process.
authors.affiliation: Department of Physiology and Pharmacology, University of Western Ontario, London, ON, Canada. Electronic address: peter.stathopulos@schulich.uwo.ca.
authors.forename: Peter B
authors.initials: PB
authors.lastname: Stathopulos
authors.affiliation: Princess Margaret Cancer Center, University Health Network; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada. Electronic address: mikura@uhnresearch.ca.
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Ikura
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism*; D020013:Calcium Signaling; D006801:Humans
chemical_list: D015220:Calcium Channels; D002118:Calcium
keywords: Crystal structure; NMR Structure; Orai1; Stoichiometry; Store operated calcium entry; Stromal interaction molecules