title: Sleep Neurophysiological Dynamics Through the Lens of Multitaper Spectral Analysis.
abstract: During sleep, cortical and subcortical structures within the brain engage in highly structured oscillatory dynamics that can be observed in the electroencephalogram (EEG). The ability to accurately describe changes in sleep state from these oscillations has thus been a major goal of sleep medicine. While numerous studies over the past 50 years have shown sleep to be a continuous, multifocal, dynamic process, long-standing clinical practice categorizes sleep EEG into discrete stages through visual inspection of 30-s epochs. By representing sleep as a coarsely discretized progression of stages, vital neurophysiological information on the dynamic interplay between sleep and arousal is lost. However, by using principled time-frequency spectral analysis methods, the rich dynamics of the sleep EEG are immediately visible-elegantly depicted and quantified at time scales ranging from a full night down to individual microevents. In this paper, we review the neurophysiology of sleep through this lens of dynamic spectral analysis. We begin by reviewing spectral estimation techniques traditionally used in sleep EEG analysis and introduce multitaper spectral analysis, a method that makes EEG spectral estimates clearer and more accurate than traditional approaches. Through the lens of the multitaper spectrogram, we review the oscillations and mechanisms underlying the traditional sleep stages. In doing so, we will demonstrate how multitaper spectral analysis makes the oscillatory structure of traditional sleep states instantaneously visible, closely paralleling the traditional hypnogram, but with a richness of information that suggests novel insights into the neural mechanisms of sleep, as well as novel clinical and research applications.
authors.affiliation: Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Charlestown, Massachusetts.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Prerau
authors.affiliation: Department of Psychiatry, Laboratory of Neuroscience, VA Boston Healthcare System and Harvard Medical School, Brockton, Massachusetts.
authors.forename: Ritchie E
authors.initials: RE
authors.lastname: Brown
authors.affiliation: Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts; and.
authors.forename: Matt T
authors.initials: MT
authors.lastname: Bianchi
authors.affiliation: Department of Neurology, Johns Hopkins University, Baltimore, Maryland.
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Ellenbogen
authors.affiliation: Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Charlestown, Massachusetts.
authors.forename: Patrick L
authors.initials: PL
authors.lastname: Purdon
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology*; D058256:Brain Waves; D003627:Data Interpretation, Statistical; D004569:Electroencephalography / Q000379:methods*; D004576:Electromyography / Q000379:methods; D006801:Humans; D051379:Mice; D012815:Signal Processing, Computer-Assisted; D012890:Sleep; D012894:Sleep Stages; D012893:Sleep Wake Disorders / Q000503:physiopathology; D014851:Wakefulness