title: Ring-Expansion Approach to Medium-Sized Lactams and Analysis of Their Medicinal Lead-Like Properties.
abstract: Medium-sized rings are widely considered to be under-represented in biological screening libraries for lead identification in medicinal chemistry. To help address this, a library of medium-sized lactams has been generated by using a simple, scalable and versatile ring-expansion protocol. Analysis of the library by using open-access computational tool LLAMA suggested that these lactams and their derivatives have highly promising physicochemical and 3D spatial properties and thus have much potential in drug discovery.
authors.affiliation: University of York, York, YO10 5DD, UK.
authors.forename: Laetitia G
authors.initials: LG
authors.lastname: Baud
authors.affiliation: University of York, York, YO10 5DD, UK.
authors.forename: Morgan A
authors.initials: MA
authors.lastname: Manning
authors.affiliation: University of York, York, YO10 5DD, UK.
authors.forename: Helen L
authors.initials: HL
authors.lastname: Arkless
authors.affiliation: University of York, York, YO10 5DD, UK.
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Stephens
authors.affiliation: University of York, York, YO10 5DD, UK.
authors.forename: William P
authors.identifier: http://orcid.org/0000-0002-9169-5156
authors.initials: WP
authors.lastname: Unsworth
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D003500:Cyclization; D015195:Drug Design; D007769:Lactams / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D007769:Lactams
keywords: amino acids; lactams; lead-oriented synthesis; medium-sized rings; ring expansion