title: Higher nocturnal systolic blood pressure in patients with restless legs syndrome compared with patients with insomnia.
abstract: BACKGROUND
  There is evidence linking restless legs syndrome (RLS) with increased blood pressure (BP), but the mechanism of this relation remains unclear. Is the BP increased due to some features of RLS or to deterioration of sleep caused by RLS? This study compared values of nocturnal BP in patients with RLS and patients with insomnia. If increased BP in RLS is a consequence of disordered sleep, then it should be similar to increased BP in insomnia.
  
  
  METHODS
  Polysomnographic recordings of patients admitted to a sleep center with RLS or insomnia were analyzed. Demographic and clinical data, objective sleep parameters, and nocturnal BP were compared.
  
  
  RESULTS
  Recordings of 35 patients with RLS and 33 patients with insomnia were analyzed. The groups did not significantly differ in terms of demographic traits or prevalence of other comorbidities. Patients with RLS had significantly higher systolic BP during the night (122.4 ± 13.8 vs 116.3 ± 13.4; p = 0.03) and during sleep (121.4 ± 13.3 vs 115.7 ± 13.3; p = 0.04). The only significant difference in sleep architecture was an increased number of periodic limb movements in sleep (PLMS) and PLMS with arousal in the RLS group (25.5 ± 24.6 vs 13.9 ± 22.7; p = 0.02 and 4.7 ± 5.4 vs 2.1 ± 3.4; p = 0.01).
  
  
  CONCLUSIONS
  Our results suggest that patients with RLS have higher nocturnal BP than patients with insomnia, and that increased PLMS is related to the increase in BP.
authors.affiliation: Medical University of Gdansk, Department of Adults' Neurology, Gdansk, Poland. Electronic address: msiem@wp.pl.
authors.forename: Mariusz
authors.initials: M
authors.lastname: Sieminski
authors.affiliation: Medical University of Gdansk, Department of Adults' Neurology, Gdansk, Poland.
authors.forename: Kamil
authors.initials: K
authors.lastname: Chwojnicki
authors.affiliation: VitalMed Helsinki Sleep Center, Helsinki, Finland.
authors.forename: Markku
authors.initials: M
authors.lastname: Partinen
mesh_terms: D000328:Adult; D001794:Blood Pressure; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012148:Restless Legs Syndrome; D007319:Sleep Initiation and Maintenance Disorders
keywords: Blood pressure; Insomnia; Periodic limb movements; Restless legs syndrome