title: High-resolution manometry in patients with idiopathic inflammatory myopathy: Elevated prevalence of esophageal involvement and differences according to autoantibody status and clinical subset.
abstract: In this study we assessed high-resolution manometry (HRM) findings in patients with dermatomyositis and polymyositis.
  
  
  
  From 2008 to 2015, we performed a cross-sectional study of myositis patients. A survey of esophageal symptoms and HRM data were analyzed and compared among different clinical and serologic groups.
  
  
  
  Twenty-four (45%) of the 53 patients included in the study had manometric involvement that was not correlated with any esophageal symptom (P = 0.8). Failed waves (34% vs. 0%, P = 0.004) and decreased upper esophageal sphincter pressure (50 vs. 70 mm Hg, P = 0.03) were more common in polymyositis than in dermatomyositis patients. Jackhammer esophagus was more common in anti-TIF1-γ patients (30% vs. 9%, P = 0.04), and lower esophageal sphincter involvement (47% vs. 25%, P = 0.03) was more prevalent in patients with the antisynthetase syndrome.
  
  
  
  Esophageal involvement is common in myositis patients, but it correlates poorly with esophageal symptoms. Specific clinical and serologic groups have different manometric features. Muscle Nerve 56: 386-392, 2017.
authors.affiliation: Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
authors.forename: Maria
authors.initials: M
authors.lastname: Casal-Dominguez
authors.affiliation: Autoimmune Systemic Diseases Unit, Department of Internal Medicine, Vall d'Hebron University Hospital, Passeig de la Vall d'Hebron, 119-129, 08035, Barcelona, Spain.|Universitat Autònoma de Barcelona, Bellaterra, Cerdanyola del Vallès, Barcelona, Spain.
authors.forename: Iago
authors.identifier: 0000-0001-6338-9218
authors.initials: I
authors.lastname: Pinal-Fernandez
authors.affiliation: Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (Ciberehd). Digestive System Research Unit, Vall d'Hebron University Hospital, Barcelona, Spain.
authors.forename: Marianela
authors.initials: M
authors.lastname: Mego
authors.affiliation: Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (Ciberehd). Digestive System Research Unit, Vall d'Hebron University Hospital, Barcelona, Spain.|Universitat Autònoma de Barcelona, Bellaterra, Cerdanyola del Vallès, Barcelona, Spain.
authors.forename: Anna
authors.initials: A
authors.lastname: Accarino
authors.affiliation: Autoimmune Systemic Diseases Unit, Department of Internal Medicine, Vall d'Hebron University Hospital, Passeig de la Vall d'Hebron, 119-129, 08035, Barcelona, Spain.
authors.forename: Lluis
authors.initials: L
authors.lastname: Jubany
authors.affiliation: Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (Ciberehd). Digestive System Research Unit, Vall d'Hebron University Hospital, Barcelona, Spain.|Universitat Autònoma de Barcelona, Bellaterra, Cerdanyola del Vallès, Barcelona, Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: Azpiroz
authors.affiliation: Autoimmune Systemic Diseases Unit, Department of Internal Medicine, Vall d'Hebron University Hospital, Passeig de la Vall d'Hebron, 119-129, 08035, Barcelona, Spain.|Universitat Autònoma de Barcelona, Bellaterra, Cerdanyola del Vallès, Barcelona, Spain.
authors.forename: Albert
authors.initials: A
authors.lastname: Selva-O'callaghan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000097:blood*; D003430:Cross-Sectional Studies; D015154:Esophageal Motility Disorders / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology*; D049630:Esophageal Sphincter, Lower / Q000503:physiopathology; D004947:Esophagus / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008365:Manometry / Q000379:methods; D008875:Middle Aged; D009220:Myositis / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology*; D015995:Prevalence
chemical_list: D001323:Autoantibodies
keywords: autoantibodies; dermatomyositis; dysphagia; esophageal involvement; high-resolution manometry; polymyositis