title: Dedifferentiated chordoid meningioma with rhabdomyosarcomatous differentiation on the middle cranial fossa.
abstract: A 46-year-old woman presented with headache and right hemiparesis. MRI demonstrated a mass in the left middle fossa. Total resection was performed. A histological examination of the tumor specimen showed several characteristic morphological features. A chordoid meningioma showing an epithelial-like palisade arrangement was observed. An anaplastic short spindle cell tumor exhibiting a fascicular pattern was considered to be a rhabdomyosarcoma. After conventional radiotherapy, the tumor was well controlled without any neurological deficit for 20 months. When subsequent recurrences were observed, the patient was treated by surgery, stereotactic radiosurgery and chemotherapy. Thirty-two months after the initial treatment, the patient died due to intracranial dissemination and an autopsy was performed. The histological examination of the recurrent and autopsy specimens showed a prominent sarcoma component. This case appears to be the first reported intracranial tumor diagnosed as a dedifferentiated chordoid meningioma with rhabdomyosarcomatous differentiation.
authors.affiliation: Department of Neurosurgery, Oita University Faculty of Medicine, Oita, Japan.
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Fudaba
authors.affiliation: Department of Neurosurgery, Oita University Faculty of Medicine, Oita, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Abe
authors.affiliation: Department of Neurosurgery, Oita University Faculty of Medicine, Oita, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Morishige
authors.affiliation: Department of Neurosurgery, Oita University Faculty of Medicine, Oita, Japan.
authors.forename: Yasutomo
authors.initials: Y
authors.lastname: Momii
authors.affiliation: Department of Clinical Laboratory, Oita Prefectural Hospital, Oita, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Kashima
authors.affiliation: Department of Neurosurgery, Nagatomi Neurosurgical Hospital, Oita, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Yamada
authors.affiliation: Department of Neurosurgery, Nagatomi Neurosurgical Hospital, Oita, Japan.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Nagatomi
authors.affiliation: Department of Neurosurgery, Nagoya University School of Medicine, Aichi, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Natsume
authors.affiliation: Clinical department of Pathology, Gunma University Hospital, Gunma, Japan.
authors.forename: Junko
authors.initials: J
authors.lastname: Hirato
authors.affiliation: Department of Pathology, Hidaka Hospital, Gunma, Japan.
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Nakazato
authors.affiliation: Department of Neurosurgery, Oita University Faculty of Medicine, Oita, Japan.
authors.forename: Minoru
authors.initials: M
authors.lastname: Fujiki
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D054337:Cell Dedifferentiation; D035301:Cranial Fossa, Middle / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006801:Humans; D008577:Meningeal Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D008579:Meningioma / Q000000981:diagnostic imaging* / Q000473:pathology; D008875:Middle Aged; D019292:Skull Base Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology
keywords: brain neoplasms; cell dedifferentiation; meningioma; middle cranial fossa; rhabdomyosarcoma