title: Serum substance P concentrations to predict oocyte maturation index and clinical pregnancy.
abstract: OBJECTIVE
  The aim of this study was to assess the predictive value of serum substance P (SP) concentrations on oocyte maturation and clinical pregnancy.
  
  
  METHODS
  Ninety-three women with unexplained infertility underwent intracytoplasmic sperm injection (ICSI) cycles. Antagonist protocol was started for each participant and at the day of oocyte pick up, serum samples were obtained from each participant to assess SP concentrations, and these concentrations were utilized to predict mature/total oocyte ratio and clinical pregnancy.
  
  
  RESULTS
  SP concentration was a significant predictor for mature/total oocyte ratio > 0.75 and clinical pregnancy. In correlation analyses, maturation index was significantly correlated with FSH (r= -0.226, p = 0.03), estradiol (r = 0.239, p = 0.021), peak estradiol (r = 0.414, p < 0.001), and substance P (r = 0.796, p < 0.001). In multivariate analyses, number of immature (beta coefficient = -0.379, p < 0.001), mature oocyte (beta coefficient = 0.473, p < 0.001), SP concentration (beta coefficient = 0.723, p < 0.001) and maturation index (beta coefficient = -0.387, p = 0.003) were significantly associated with clinical pregnancy.
  
  
  CONCLUSIONS
  SP concentrations at the day of oocyte pick up may be used to predict clinical pregnancy and may be an indirect indicator for cycle outcome in assisted reproductive technology (ART).
authors.affiliation: a Department of Obstetrics and Gynecology , Zeynep Kamil Training and Research Hospital , Istanbul , Turkey.
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Sahin
authors.affiliation: a Department of Obstetrics and Gynecology , Zeynep Kamil Training and Research Hospital , Istanbul , Turkey.
authors.forename: Enis
authors.initials: E
authors.lastname: Özkaya
authors.affiliation: a Department of Obstetrics and Gynecology , Zeynep Kamil Training and Research Hospital , Istanbul , Turkey.
authors.forename: Semra
authors.initials: S
authors.lastname: Kayatas Eser
authors.affiliation: a Department of Obstetrics and Gynecology , Zeynep Kamil Training and Research Hospital , Istanbul , Turkey.
authors.forename: Tayfun
authors.initials: T
authors.lastname: Kutlu
authors.affiliation: a Department of Obstetrics and Gynecology , Zeynep Kamil Training and Research Hospital , Istanbul , Turkey.
authors.forename: Ilhan
authors.initials: I
authors.lastname: Sanverdi
authors.affiliation: a Department of Obstetrics and Gynecology , Zeynep Kamil Training and Research Hospital , Istanbul , Turkey.
authors.forename: Gulden
authors.initials: G
authors.lastname: Tunali
authors.affiliation: a Department of Obstetrics and Gynecology , Zeynep Kamil Training and Research Hospital , Istanbul , Turkey.
authors.forename: Ates
authors.initials: A
authors.lastname: Karateke
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D003430:Cross-Sectional Studies; D005260:Female; D006784:Hospitals, Teaching; D006801:Humans; D059471:In Vitro Oocyte Maturation Techniques; D007247:Infertility, Female / Q000097:blood / Q000628:therapy*; D007986:Luteinizing Hormone / Q000494:pharmacology; D054315:Oocyte Retrieval; D009866:Oogenesis / Q000187:drug effects; D010062:Ovulation Induction; D011237:Predictive Value of Tests; D011247:Pregnancy; D018873:Pregnancy Rate; D011258:Pregnancy Tests; D012372:ROC Curve; D020554:Sperm Injections, Intracytoplasmic; D013373:Substance P / Q000097:blood*; D014421:Turkey
chemical_list: D015415:Biomarkers; D006063:Chorionic Gonadotropin; D013373:Substance P; D007986:Luteinizing Hormone
keywords: Assisted reproduction; implantation; maturation index; substance P