title: Polyadenylation and degradation of RNA in the mitochondria.
abstract: Mitochondria have their own gene expression machinery and the relative abundance of RNA products in these organelles in animals is mostly dictated by their rate of degradation. The molecular mechanisms regulating the differential accumulation of the transcripts in this organelle remain largely elusive. Here, we summarize the present knowledge of how RNA is degraded in human mitochondria and describe the coexistence of stable poly(A) tails and the nonabundant tails, which have been suggested to play a role in the RNA degradation process.
authors.affiliation: Faculty of Biology, Technion - Israel Institute of Technology, Haifa 32000, Israel.
authors.forename: Shiri
authors.initials: S
authors.lastname: Levy
authors.affiliation: Faculty of Biology, Technion - Israel Institute of Technology, Haifa 32000, Israel.
authors.forename: Gadi
authors.initials: G
authors.lastname: Schuster
mesh_terms: D000818:Animals; D001483:Base Sequence; D015870:Gene Expression; D006801:Humans; D008928:Mitochondria / Q000235:genetics* / Q000378:metabolism; D008957:Models, Genetic; D026723:Polyadenylation; D012313:RNA / Q000235:genetics* / Q000378:metabolism; D020871:RNA Stability; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D000077278:RNA, Mitochondrial
chemical_list: D012333:RNA, Messenger; D000077278:RNA, Mitochondrial; D012313:RNA
keywords: RNA degradation; mitochondria; polyadenylation