title: Drug governs the morphology of polyalkylated block copolymer aggregates.
abstract: Polyalkylated copolymers based on mPEG-b-(AGE-C6,12 or 18)25have been used to formulate clinically relevant concentrations of doxorubicin (DOX) and the impact of drug incorporation on copolymer aggregation behaviour was examined. The copolymer aggregates were analyzed by various microscopy techniques (TEM, cryo-TEM and AFM) and scattering methods (SANS, DLS). In the absence of the drug, the copolymers formed largely non-spherical aggregates (i.e. cylinders, vesicles). Drug incorporation during copolymer aggregate formation directed the formation of only spherical aggregates. As well, the nature of the core-forming block was found to influence drug release and cytotoxicity of the formulations.
authors.affiliation: Leslie Dan Faculty of Pharmacy, Department of Pharmaceutical Sciences, University of Toronto, Canada. cj.allen@utoronto.ca.
authors.forename: F
authors.initials: F
authors.lastname: Le Dévédec
authors.affiliation: Leslie Dan Faculty of Pharmacy, Department of Pharmaceutical Sciences, University of Toronto, Canada. cj.allen@utoronto.ca.
authors.forename: S
authors.initials: S
authors.lastname: Her
authors.affiliation: CEAS-Biomedical, Chemical, and Environmental Engineering, University of Cincinnati, USA.
authors.forename: K
authors.initials: K
authors.lastname: Vogtt
authors.affiliation: Institute of Biomaterials and Biomedical Engineering, University of Toronto, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Won
authors.affiliation: Leslie Dan Faculty of Pharmacy, Department of Pharmaceutical Sciences, University of Toronto, Canada. cj.allen@utoronto.ca.
authors.forename: X
authors.initials: X
authors.lastname: Li
authors.affiliation: CEAS-Biomedical, Chemical, and Environmental Engineering, University of Cincinnati, USA.
authors.forename: G
authors.initials: G
authors.lastname: Beaucage
authors.affiliation: Institute of Biomaterials and Biomedical Engineering, University of Toronto, Canada.
authors.forename: C
authors.initials: C
authors.lastname: Yip
authors.affiliation: Leslie Dan Faculty of Pharmacy, Department of Pharmaceutical Sciences, University of Toronto, Canada. cj.allen@utoronto.ca and Institute of Biomaterials and Biomedical Engineering, University of Toronto, Canada.
authors.forename: C
authors.initials: C
authors.lastname: Allen