title: CARD9 as a potential target in cardiovascular disease.
abstract: Systemic inflammation and localized macrophage infiltration have been implicated in cardiovascular pathologies, including coronary artery disease, carotid atherosclerosis, heart failure, obesity-associated heart dysfunction, and cardiac fibrosis. Inflammation induces macrophage infiltration and activation and release of cytokines and chemokines, causing tissue dysfunction by instigating a positive feedback loop that further propagates inflammation. Cytosolic adaptor caspase recruitment domain family, member 9 (CARD9) is a protein expressed primarily by dendritic cells, neutrophils, and macrophages, in which it mediates cytokine secretion. The purpose of this review is to highlight the role of CARD9 as a potential target in inflammation-related cardiovascular pathologies.
authors.affiliation: School of Pharmacy, University of Wyoming, College of Health Sciences, Laramie, WY, USA.
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Peterson
authors.affiliation: School of Pharmacy, University of Wyoming, College of Health Sciences, Laramie, WY, USA.
authors.forename: Samantha E
authors.initials: SE
authors.lastname: Haller
authors.affiliation: School of Pharmacy, University of Wyoming, College of Health Sciences, Laramie, WY, USA.
authors.forename: Jun
authors.initials: J
authors.lastname: Ren
authors.affiliation: School of Pharmacy, University of Wyoming, College of Health Sciences, Laramie, WY, USA.
authors.forename: Sreejayan
authors.initials: S
authors.lastname: Nair
authors.affiliation: School of Pharmacy, University of Wyoming, College of Health Sciences, Laramie, WY, USA.
authors.forename: Guanglong
authors.initials: G
authors.lastname: He
mesh_terms: D053468:CARD Signaling Adaptor Proteins / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology; D009202:Cardiomyopathies / Q000378:metabolism* / Q000503:physiopathology; D018925:Chemokines / Q000737:chemistry / Q000378:metabolism*; D016207:Cytokines / Q000737:chemistry / Q000378:metabolism*; D003713:Dendritic Cells / Q000737:chemistry / Q000378:metabolism*; D006333:Heart Failure / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008264:Macrophages / Q000737:chemistry*; D009206:Myocardium / Q000737:chemistry / Q000473:pathology*; D016328:NF-kappa B / Q000737:chemistry* / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D053468:CARD Signaling Adaptor Proteins; D018925:Chemokines; D016207:Cytokines; D016328:NF-kappa B
keywords: heart failure; hypertension; inflammation; pressure-overload