title: Follistatin-like protein 1 suppressed pro-inflammatory cytokines expression during neuroinflammation induced by lipopolysaccharide.
abstract: Follistain-like protein 1 (FSTL1), has been recently demonstrated to be involved in the embryo development of nervous system and glioblastoma. However, the role of FSTL1 in neuroinflammation remains unexplored. In this study, the expression of FSTL1 in astrocytes was verified and its role was studied in neuroinflammation induced by in vivo intracerebroventricular (ICV) injection of lipopolysaccharide (LPS) or LPS treatment to astrocytes in vitro. FSTL1 was significantly induced after ICV LPS injection or LPS treatment. FSTL1 suppressed upregulation of pro-inflammatory cytokines in astrocytes after LPS treatment. Moreover, FSTL1 downregulated expression of pro-inflammatory cytokines through suppressing MAPK/p-ERK1/2 pathway in astrocytes. Our results suggest that FSTL1 may play an anti-inflammatory role in neuroinflammation mediated by astrocytes.
authors.affiliation: Department of Orthopaedics, Qilu Hospital of Shandong University, Jinan, 250012, China.
authors.forename: Kai-Yuan
authors.initials: KY
authors.lastname: Cheng
authors.affiliation: Department of Orthopaedics, Qilu Hospital of Shandong University, Jinan, 250012, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Orthopaedics, Qilu Hospital of Shandong University, Jinan, 250012, China.
authors.forename: Ying-Guang
authors.initials: YG
authors.lastname: Han
authors.affiliation: Department of Orthopaedics, Qilu Hospital of Shandong University, Jinan, 250012, China.
authors.forename: Jing-Kun
authors.initials: JK
authors.lastname: Li
authors.affiliation: Department of Orthopaedics, Qilu Hospital of Shandong University, Jinan, 250012, China.
authors.forename: Jia-Lin
authors.initials: JL
authors.lastname: Jia
authors.affiliation: Department of Orthopaedics, Qilu Hospital of Shandong University, Jinan, 250012, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Chen
authors.affiliation: Department of Orthopaedics, Qilu Hospital of Shandong University, Jinan, 250012, China.
authors.forename: Zhi-Xiao
authors.initials: ZX
authors.lastname: Yao
authors.affiliation: Department of Orthopaedics, Qilu Hospital of Shandong University, Jinan, 250012, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Nie
authors.affiliation: Department of Orthopaedics, Qilu Hospital of Shandong University, Jinan, 250012, China. chengleiyx@126.com.
authors.forename: Lei
authors.initials: L
authors.lastname: Cheng
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D001253:Astrocytes / Q000378:metabolism / Q000473:pathology*; D016207:Cytokines / Q000378:metabolism*; D038702:Follistatin-Related Proteins / Q000235:genetics / Q000494:pharmacology / Q000502:physiology*; D005786:Gene Expression Regulation; D006801:Humans; D007249:Inflammation / Q000139:chemically induced / Q000378:metabolism*; D008070:Lipopolysaccharides; D020935:MAP Kinase Signaling System / Q000187:drug effects; D016328:NF-kappa B / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D016207:Cytokines; D038702:Follistatin-Related Proteins; D008070:Lipopolysaccharides; D016328:NF-kappa B
keywords: Anti-inflammatory; Astrocyte; FSTL1; Neuroinflammation