title: Polysorbate 80 and polymyxin B inhibit Stenotrophomonas maltophilia biofilm.
abstract: Stenotrophomonas maltophilia is an opportunistic multiple-drug-resistant human pathogen that forms biofilms on implanted medical devices. We examined the potential inhibitory activity of polysorbate 80 and polymyxin B against S. maltophilia. A combination of subMIC polymyxin B and polysorbate 80 was the most effective inhibitor of growth and biofilm formation.
authors.affiliation: Department of Biological Sciences, College of Science & Health, DePaul University, Chicago, IL 60614.
authors.forename: Adam M
authors.initials: AM
authors.lastname: Malinowski
authors.affiliation: Department of Biological Sciences, College of Science & Health, DePaul University, Chicago, IL 60614.
authors.forename: Bryan M
authors.initials: BM
authors.lastname: McClarty
authors.affiliation: Department of Biological Sciences, College of Science & Health, DePaul University, Chicago, IL 60614.
authors.forename: Carolyn
authors.initials: C
authors.lastname: Robinson
authors.affiliation: Department of Biological Sciences, College of Science & Health, DePaul University, Chicago, IL 60614.
authors.forename: William
authors.initials: W
authors.lastname: Spear
authors.affiliation: Department of Biological Sciences, College of Science & Health, DePaul University, Chicago, IL 60614.
authors.forename: Maria
authors.initials: M
authors.lastname: Sanchez
authors.affiliation: Department of Biological Sciences, College of Science & Health, DePaul University, Chicago, IL 60614.
authors.forename: Timothy C
authors.initials: TC
authors.lastname: Sparkes
authors.affiliation: Department of Biological Sciences, College of Science & Health, DePaul University, Chicago, IL 60614. Electronic address: jbrooke@depaul.edu.
authors.forename: Joanna S
authors.initials: JS
authors.lastname: Brooke
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects*; D004347:Drug Interactions; D006801:Humans; D008826:Microbial Sensitivity Tests; D011112:Polymyxin B / Q000494:pharmacology*; D011136:Polysorbates / Q000494:pharmacology*; D020615:Stenotrophomonas maltophilia / Q000187:drug effects* / Q000502:physiology*; D013501:Surface-Active Agents / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D011136:Polysorbates; D013501:Surface-Active Agents; D011112:Polymyxin B
keywords: Biofilm; Polymyxin B; Polysorbate; Stenotrophomonas; Surfactant; subMIC