title: Influence of Donor and Recipient Ages in Survival of Simultaneous Pancreas-Kidney Transplantation.
abstract: BACKGROUND
  Simultaneous pancreas-kidney transplantation (SPKT) is a well treatment for patients with insulin-dependent diabetes and end-stage renal disease. Donor age is a barrier to the acceptance of organs. Age matching has been extensively studied in kidney transplantation; however, there are no studies in graft survival after SPKT. We aimed to study the combined influence of the ages of the donors and recipients in graft survival after SPKT.
  
  
  METHODS
  Donors and recipients are classified as younger (age <40 years) or older (age ≥40 years). There were four study groups (young-young, young-old, old-young, and old-old). They were evaluated retrospectively for demographic and clinical characteristics of donors and recipients and the long-term survival between 2001 and 2012 of kidney pancreas transplantation patients at our center.
  
  
  RESULTS
  A total of 115 transplantations were performed. The four groups had 55 young-young, 40 young-old, 10 old-young, and 10 old-old patients. Serious complications occurred in 32%, 42%, 30%, and 40%, respectively, and deaths were 2%, 5%, 0%, and 20%, respectively, in the groups. Pancreas graft survival at 3 years for each group was 80%, 87, 5%, 90%, and 60%, respectively, and kidney graft survival was 92.7%, 90%, 90%, and 70%, respectively. Panel-reactive antibodies (PRAs) >30% were associated with poor graft survival, and serious postoperative complications associated with poor pancreas-kidney graft survival.
  
  
  CONCLUSIONS
  In conclusion, both younger and older recipients show excellent long-term graft and patient survival after SPKTs from younger donors. We recommended that older-recipient SPKT be transplanted from younger donors because older recipients who have been transplanted from older donors had decreased survival.
authors.affiliation: Department of Urology, University Hospital Reina Sofía, Córdoba, Spain. Electronic address: areber87@hotmail.com.
authors.forename: A J
authors.initials: AJ
authors.lastname: Arenas-Bonilla
authors.affiliation: Department of Urology, University Hospital Reina Sofía, Córdoba, Spain.
authors.forename: J P
authors.initials: JP
authors.lastname: Campos-Hernández
authors.affiliation: Department of Urology, University Hospital Reina Sofía, Córdoba, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Carrasco-Valiente
authors.affiliation: Department of Urology, University Hospital Reina Sofía, Córdoba, Spain.
authors.forename: F J
authors.initials: FJ
authors.lastname: Márquez-López
authors.affiliation: Department of Urology, University Hospital Reina Sofía, Córdoba, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Ruiz-García
authors.affiliation: Department of Urology, University Hospital Reina Sofía, Córdoba, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Sánchez-Gónzalez
authors.affiliation: Department of Urology, University Hospital Reina Sofía, Córdoba, Spain.
authors.forename: J J
authors.initials: JJ
authors.lastname: Salamanca-Bustos
authors.affiliation: Department of Urology, University Hospital Reina Sofía, Córdoba, Spain.
authors.forename: J C
authors.initials: JC
authors.lastname: Regueiro-López
authors.affiliation: Department of Nephrology, University Hospital Reina Sofía, Córdoba, Spain.
authors.forename: M D
authors.initials: MD
authors.lastname: Navarro-Cabello
authors.affiliation: Department of Urology, University Hospital Reina Sofía, Córdoba, Spain.
authors.forename: M J
authors.initials: MJ
authors.lastname: Requena-Tapia
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D003922:Diabetes Mellitus, Type 1 / Q000601:surgery; D005260:Female; D006085:Graft Survival / Q000502:physiology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000601:surgery; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D016035:Pancreas Transplantation; D011183:Postoperative Complications / Q000209:etiology; D012189:Retrospective Studies; D014019:Tissue Donors; D066027:Transplant Recipients