title: Bedside cardiovascular maternal interrogation in the first trimester to predict different phenotypes of hypertensive disorders in pregnancy.
abstract: OBJECTIVE
  The aim is to evaluate if maternal cardiovascular indices, in the first trimester of pregnancy, might be useful to differentiate women who develop different hypertensive disorders of pregnancy (HDP).
  
  
  METHODS
  Method: 1399 pregnant women attending screening for chromosomal aneuploidies were recruited. The following parameters were measured: Doppler Velocimetry of uterine arteries; Peripheral blood pressure; Aortic Pressure derived from applanation tonometry. Primary outcome were: women who developed HDP associated with newborns with an appropriate weight for local gestational age standards (AGA) and women that developed HDP associated with a newborn weight below the 10th centile (SGA).
  
  
  RESULTS
  Mean UtA PI was significantly higher in the HDP-SGA compared with controls. HDP-AGA showed a higher rate of family history of hypertension and a higher BMI. In HDP-AGA Brachial and Aortic mean pressure were higher than controls. The most significant contributors for all forms of HDP were mean UtA PI for HDP-SGA and mean arterial blood pressure for HDP-AGA. The multivariate logistic regression for HDP-SGA shows an AUC 0.88, whereas the AUC for the prediction of HDP-AGA group was 0.71.
  
  
  CONCLUSIONS
  HDP-SGA were characterized by significantly higher values of UtA-PI, whereas HDP-AGA by mean aortic and brachial pressure and risk factors for endothelial dysfunction.
authors.affiliation: Department of Woman, Mother and Neonate, Buzzi Children's Hospital, Biomedical and Clinical Sciences, School of Medicine, University of Milan, Via Castelvetro 32, 20154 Milan, Italy. Electronic address: daniela.dimartino@icp.mi.it.
authors.forename: Daniela Denis
authors.initials: DD
authors.lastname: Di Martino
authors.affiliation: Unit of Ultrasound and Prenatal Diagnosis, Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Via dell'Istria, 65, 34137 Trieste, Italy.
authors.forename: Tamara
authors.initials: T
authors.lastname: Stampalija
authors.affiliation: Department of Woman, Mother and Neonate, Buzzi Children's Hospital, Biomedical and Clinical Sciences, School of Medicine, University of Milan, Via Castelvetro 32, 20154 Milan, Italy.
authors.forename: Eleonora
authors.initials: E
authors.lastname: Rosti
authors.affiliation: Department of Woman, Mother and Neonate, Buzzi Children's Hospital, Biomedical and Clinical Sciences, School of Medicine, University of Milan, Via Castelvetro 32, 20154 Milan, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Casati
authors.affiliation: Department of Woman, Mother and Neonate, Buzzi Children's Hospital, Biomedical and Clinical Sciences, School of Medicine, University of Milan, Via Castelvetro 32, 20154 Milan, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Signorelli
authors.affiliation: Department of Woman, Mother and Neonate, Buzzi Children's Hospital, Biomedical and Clinical Sciences, School of Medicine, University of Milan, Via Castelvetro 32, 20154 Milan, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Zullino
authors.affiliation: Department of Woman, Mother and Neonate, Buzzi Children's Hospital, Biomedical and Clinical Sciences, School of Medicine, University of Milan, Via Castelvetro 32, 20154 Milan, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Mastroianni
authors.affiliation: Unit of Ultrasound and Prenatal Diagnosis, Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Via dell'Istria, 65, 34137 Trieste, Italy.
authors.forename: Mariachiara
authors.initials: M
authors.lastname: Quadrifoglio
authors.affiliation: Department of Woman, Mother and Neonate, Buzzi Children's Hospital, Biomedical and Clinical Sciences, School of Medicine, University of Milan, Via Castelvetro 32, 20154 Milan, Italy.
authors.forename: Enrico
authors.initials: E
authors.lastname: Ferrazzi
mesh_terms: D000328:Adult; D062186:Arterial Pressure; D001783:Blood Flow Velocity; D015992:Body Mass Index; D005260:Female; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000235:genetics / Q000503:physiopathology*; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D008137:Longitudinal Studies; D010641:Phenotype; D011237:Predictive Value of Tests; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011446:Prospective Studies; D055988:Uterine Artery / Q000000981:diagnostic imaging*