title: Effects of Ginkgo biloba extract on brain oxidative condition after cisplatin exposure.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the efficacy of Ginkgo biloba extract (EGb 761) on oxidative events of brain in cisplatin-administrated rats.
  
  
  METHODS
  Rats were divided into four experimental groups: 1) control (n=6); 2) cisplatin (8 mg/kg, intraperitoneally one dose, n=6); 3) EGb 761 (100 mg/kg intraperitoneally for 15 days, n=6); and 4) cisplatin + EGb 761 (n=6). After drug administration, rats were sacrificed and brain tissues were removed. Nitric oxide (NO), malondialdehyde (MDA) and glutathione (GSH) levels were evaluated in brain tissues.
  
  
  RESULTS
  Single dose cisplatin administration significantly increased NO and GSH levels, but decreased MDA levels in brain tissue samples. EGb 761 treatment reversed the effects of cisplatin on NO and GSH levels, but did not affect the decreased MDA levels.
  
  
  CONCLUSIONS
  Results of the study indicate that oxidative stress can be an important pathogenetic mechanism of cisplatin-induced neurotoxicity. EGb 761, an standardized extract of G. biloba leaves that has antioxidant properties, may improve the oxidative stress-related neurological side effects of cisplatin.
authors.affiliation: . daydin@turgutozal.edu.tr.
authors.forename: Duygu
authors.initials: D
authors.lastname: Aydin
authors.forename: Emine G G
authors.initials: EG
authors.lastname: Peker
authors.forename: Meryem D
authors.initials: MD
authors.lastname: Karakurt
authors.forename: Ayşe
authors.initials: A
authors.lastname: Gurel
authors.forename: Mustafa
authors.initials: M
authors.lastname: Ayyildiz
authors.forename: Şule C
authors.initials: ŞC
authors.lastname: Cevher
authors.forename: Erdal
authors.initials: E
authors.lastname: Agar
authors.forename: Senol
authors.initials: S
authors.lastname: Dane
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry / Q000187:drug effects; D002945:Cisplatin / Q000494:pharmacology*; D005260:Female; D020441:Ginkgo biloba / Q000737:chemistry*; D005978:Glutathione / Q000378:metabolism; D008315:Malondialdehyde / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D010936:Plant Extracts; D009569:Nitric Oxide; D008315:Malondialdehyde; D005978:Glutathione; D002945:Cisplatin