title: ZNF208 polymorphisms associated with ischemic stroke in a southern Chinese Han population.
abstract: BACKGROUND
  Ischemic stroke is one of the most common diseases with a high burden of neurological deficits, disability and death. Zinc finger protein 208 (ZNF208) was found to be involved in coronary heart disease, although little information is available about its association with ischemic stroke. We performed the present case-control study to clarify the association between single-nucleotide polymorphisms (SNPs) within ZNF208 and the risk of ischemic stroke in a southern Chinese Han population.
  
  
  METHODS
  A total of 799 subjects (400 cases and 399 healthy controls) were enrolled in the present study. Five SNPs within ZNF208 gene were selected and genotyped using Sequenom MassARRY technology (Sequenom, Inc., San Diego, CA, USA). Data management and statistical analyses were conducted using Sequenom Typer, version 4.0, and a chi-squared test, as well as unconditional logistic regression.
  
  
  RESULTS
  Statistical results showed that three variants were associated with the risk of ischemic stroke under allele models (rs2188971, rs2188972, rs8103163 and rs7248488). The variant rs2188972 was also associated with the risk of ischemic stroke in a recessive model after adjustment for age and sex. Haplotype analysis suggested that a significant difference existed between the Ars2188972Trs2188971Ars8103163Ars7248488haplotype and the risk of ischemic stroke, although this disappeared after adjustment for sex and age.
  
  
  CONCLUSIONS
  The results obtained in the present study indicate a potential association between ZNF208 variants and the risk of ischemic risk in a southern Chinese Han population.
authors.affiliation: Department of Neurology, Affiliated Haikou Hospital of Xiangya Medical College of Central South University, Haikou Municipal Hospital, Haikou, Hainan, China.
authors.forename: Jianzhong
authors.initials: J
authors.lastname: Yu
authors.affiliation: Department of Neurology, Affiliated Haikou Hospital of Xiangya Medical College of Central South University, Haikou Municipal Hospital, Haikou, Hainan, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Zhou
authors.affiliation: Department of Neurology, Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, Zhejiang, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Luo
authors.affiliation: Department of Neurology, Affiliated Haikou Hospital of Xiangya Medical College of Central South University, Haikou Municipal Hospital, Haikou, Hainan, China.
authors.forename: Nianzhen
authors.initials: N
authors.lastname: Wang
authors.affiliation: Department of Neurology, Affiliated Haikou Hospital of Xiangya Medical College of Central South University, Haikou Municipal Hospital, Haikou, Hainan, China.
authors.forename: Chong
authors.initials: C
authors.lastname: Zhang
authors.affiliation: School of Life Sciences, Northwest University, Xi'an, Shaanxi, China.
authors.forename: Tianbo
authors.initials: T
authors.lastname: Jin
authors.affiliation: Physical Examination Center, Affiliated Haikou Hospital of Xiangya Medical College of Central South University, Haikou Municipal Hospital, Haikou, Hainan, China.
authors.forename: Xiongfei
authors.initials: X
authors.lastname: Liang
authors.affiliation: Department of Neurology, Affiliated Haikou Hospital of Xiangya Medical College of Central South University, Haikou Municipal Hospital, Haikou, Hainan, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Yu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D004268:DNA-Binding Proteins; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007511:Ischemia / Q000150:complications*; D051741:Kruppel-Like Transcription Factors / Q000235:genetics*; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D020521:Stroke / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology*; D014157:Transcription Factors
chemical_list: D004268:DNA-Binding Proteins; D051741:Kruppel-Like Transcription Factors; D014157:Transcription Factors; C403245:ZKSCAN5 protein, human
keywords: ZNF208; case-control study; single-nucleotide polymorphism; stroke