title: [Mid- to long-term outcomes of cervical disc arthroplasty for symptomatic cervical disc disease: a meta-analysis].
abstract: Objective:To compare the benefits and harms of cervical disc arthroplasty (CDA) with anterior cervical discectomy and fusion(ACDF) for symptomatic cervical disc disease at mid- to long-term follow-up.Methods:Electronic searches were made in PubMed, EMBASE, and the Cochrane Library for randomized controlled trials with at least 48 moths follow-up.Outcomes were reported as relative risk or standardized mean difference.Meta-analysis was carried out using Revman version 5.3 and Stata version 12.0.Results:Seven trials were included, involving 2 302 participants.The results of this meta-analysis indicated that CDA brought about fewer secondary surgical procedures, lower neck disability index (NDI) scores, lower neck and arm pain scores, greater SF-36 Physical Component Summary (PCS) and Mental Component Summary(MCS) scores, greater range of motion (ROM) at the operative level and less superior adjacent-segment degeneration(P<0.05) than ACDF.CDA was not statistically different from ACDF in inferior adjacent-segment degeneration, neurological success, and adverse events (P>0.05).Conclusions:CDA can significantly reduce the rates of secondary surgical procedures compared with ACDF.Meanwhile, CDA is superior or equivalent to ACDF in other aspects.As some studies without double-blind are included and some potential biases exites, more randomized controlled trials with high quality are required to get more reliable conclusions.
authors.affiliation: Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin 300052, China.
authors.forename: S L
authors.initials: SL
authors.lastname: Kan
authors.forename: B
authors.initials: B
authors.lastname: Yang
authors.forename: G Z
authors.initials: GZ
authors.lastname: Ning
authors.forename: S J
authors.initials: SJ
authors.lastname: Gao
authors.forename: J C
authors.initials: JC
authors.lastname: Sun
authors.forename: S Q
authors.initials: SQ
authors.lastname: Feng
mesh_terms: D001178:Arthroplasty; D002574:Cervical Vertebrae; D017586:Diskectomy; D004311:Double-Blind Method; D006801:Humans; D007403:Intervertebral Disc; D055959:Intervertebral Disc Degeneration / Q000601:surgery*; D007405:Intervertebral Disc Displacement / Q000601:surgery*; D009333:Neck; D016032:Randomized Controlled Trials as Topic; D016059:Range of Motion, Articular; D013123:Spinal Fusion; D016896:Treatment Outcome