title: Fixed combination calcipotriol plus betamethasone dipropionate aerosol foam in the treatment of psoriasis vulgaris: rationale for development and clinical profile.
abstract: Psoriasis is a chronic, immune-mediated inflammatory disorder with a significant negative impact on quality of life. Most patients with mild-to-moderate psoriasis manage their disease with topical therapies; the most commonly used formulations contain corticosteroids and/or vitamin D3 analogues. However, adherence to topical treatment remains a significant issue as the daily treatment regimen can be cumbersome and time consuming and many patients do not obtain complete/almost complete clearance. Areas covered: Published pre-clinical and clinical data evaluating calcipotriol 50 µg/g (Cal) and betamethasone 0.5 mg/g as dipropionate (BD) aerosol foam in patients with psoriasis. Expert opinion: Cal/BD aerosol foam, a once-daily, alcohol-free, paraffin-based vehicle with emollient properties, was developed to increase the therapeutic options available to patients. Cal/BD aerosol foam is rapidly effective for treating psoriasis and the greater efficacy compared with the ointment and gel formulations is consistent and clinically relevant. This enhanced efficacy is due to improved skin penetration of the active ingredients following the formation of a stable supersaturated solution on the skin. Studies have shown increasing patient satisfaction with Cal/BD aerosol foam. It is hoped that this optimized formulation of Cal/BD will improve adherence and help to address the unmet medical needs of patients with mild-to-moderate psoriasis.
authors.affiliation: a Professor and Chairman of the Department of Dermatology , Paul Sabatier University and Larrey Hospital , Toulouse , France.
authors.forename: Carle
authors.initials: C
authors.lastname: Paul
authors.affiliation: b Medical Lead, Skin inflammation Projects , LEO Pharma A/S , Ballerup , Denmark.
authors.forename: Bo
authors.initials: B
authors.lastname: Bang
authors.affiliation: c Professor and System Chair of the Department of Dermatology , Icahn School of Medicine at Mount Sinai , New York , NY , USA.
authors.forename: Mark
authors.initials: M
authors.lastname: Lebwohl
mesh_terms: D000336:Aerosols; D001623:Betamethasone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002117:Calcitriol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003879:Dermatologic Agents / Q000627:therapeutic use*; D004338:Drug Combinations; D006801:Humans; D009824:Ointments; D011565:Psoriasis / Q000188:drug therapy*; D011788:Quality of Life; D016896:Treatment Outcome
chemical_list: D000336:Aerosols; D003879:Dermatologic Agents; D004338:Drug Combinations; D009824:Ointments; C517164:betamethasone dipropionate, calcipotriol drug combination; D001623:Betamethasone; D002117:Calcitriol
keywords: Aerosol foam; betamethasone dipropionate; calcipotriol; psoriasis