title: Increased Expression of Matrix Metalloproteinase-1 and 3 in Remission Patients of Steroid-Dependent Ulcerative Colitis.
abstract: BACKGROUND
  This study was to investigate the pathological significance of protein expression of matrix metalloproteinase-1 (MMP1) and matrix metalloproteinase-3 (MMP3) in colon tissues of remission patients of steroid-dependent uncreative colitis (SDUC).
  
  
  METHODS
  To test the possible involvement of MMP-1 and MMP-3 in SDUC, Western- blot and immunohistochemistry were applied to examine the protein expression of MMP-1 and MMP-3 in the colonic healing region from 10 remission patients with SDUC as well as from 10 remission patients with non-SDUC. Ten specimens from normal colon tissues were used as controls.
  
  
  RESULTS
  Compared with the control group, the protein expression of MMP-1 and MMP-3 from non-SDUC remission patients slightly increased (p > 0.05), in contrast, those from SDUC patients significantly increased (p < 0.01).
  
  
  CONCLUSIONS
  Over-expression of MMP-1 and MMP-3 play a critical role in the pathogenesis of SDUC.
authors.affiliation: Department of Digestive Diseases, Affiliated Hospital of Hangzhou Normal University (the Second People's Hospital of Hangzhou City), Hangzhou 310015, Zhejiang Province, China.
authors.forename: Zhi Yong
authors.initials: ZY
authors.lastname: Wang
authors.affiliation: Department of Digestive Diseases, Affiliated Hospital of Hangzhou Normal University (the Second People's Hospital of Hangzhou City), Hangzhou 310015, Zhejiang Province, China.
authors.forename: Bing Feng
authors.initials: BF
authors.lastname: Qiu
keywords: Metalloproteinase; Steroid-dependent; Ulcerative colitis