title: Implementing the Risk of Ovarian Malignancy Algorithm Adding Obesity as a Predictive Factor.
abstract: To evaluate whether obesity represents a risk factor for the onset of ovarian cancer.
  
  
  
  One hundred and sixty-three patients with a body mass index (BMI) >30 kg/m2(group 1) and 130 women with a BMI of <25 kg/m2(group 2) were included in the study.
  
  
  
  A Risk of Ovarian Malignancy Algorithm (ROMA) index above the cut-off (>13%) was found in 24.5% of group 1 patients, whereas a high ROMA score was identified in 5.3% of group 2 women. During the study, 13 out of 40 group 1 patients with ROMA >13% were deemed eligible for bariatric surgery. After bariatric surgery and decrease of BMI, eight out of these 13 obese women had a ROMA index <13%.
  
  
  
  The ROMA index may function as a simple test able to screen obese women at risk of developing ovarian cancer.
authors.affiliation: Department of Molecular Medicine, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy emanuela.anastasi@uniroma1.it.
authors.forename: Emanuela
authors.initials: E
authors.lastname: Anastasi
authors.affiliation: Department of Experimental Medicine, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
authors.forename: Danila
authors.initials: D
authors.lastname: Capoccia
authors.affiliation: CNR-IBPM, National Research Council, Rome, Italy.
authors.forename: Teresa
authors.initials: T
authors.lastname: Granato
authors.affiliation: Department of Medico-Surgical Sciences and Biotechnologies, Bariatric Center of Excellence IFSO EU, Sapienza University of Rome, Latina, Italy.
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Silecchia
authors.affiliation: Department of Medico-Surgical Sciences and Biotechnologies, Bariatric Center of Excellence IFSO EU, Sapienza University of Rome, Latina, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Rizzello
authors.affiliation: Department of Gynaecology, Obstetrics and Urology, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Porpora
authors.affiliation: Department of Molecular Medicine, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Frati
authors.affiliation: Department of Molecular Medicine, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Angeloni
authors.affiliation: Department of Experimental Medicine, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
authors.forename: Frida
authors.initials: F
authors.lastname: Leonetti
mesh_terms: D000328:Adult; D000465:Algorithms; D015992:Body Mass Index; D005260:Female; D006801:Humans; D008875:Middle Aged; D009765:Obesity / Q000150:complications*; D010051:Ovarian Neoplasms / Q000150:complications / Q000453:epidemiology*; D012307:Risk Factors; D055815:Young Adult
keywords: CA125; HE4; Obesity; ROMA index; bariatric surgery; insulin; ovarian cancer