title: Hemodynamic coherence in patients with burns.
abstract: Burn shock is characterized by profound hemodynamic alterations mainly associated with rapid loss of intravascular volume related to severe capillary leak. Thus, fluid resuscitation conventionally based on macrocirculatory targets is considered as a corner stone of initial management of patients with burns. Nonetheless, traditional markers such as blood pressure, urinary output, and cardiac output are helpful but do not sufficiently reflect the adequacy of perfusion and oxygenation at the microcirculatory level. Microcirculatory alterations have been identified in patients with severe burns even when macrocirculatory variables are within therapeutic goals. In this review, we discuss the pathophysiology of the microvascular alterations in burn shock, its coherence with macrocirculatory physiologic variables, and potential future implications for the treatment of burn shock.
authors.affiliation: Department of Anesthesiology and Critical Care and Burn Unit, AP-HP, Hôpital Saint-Louis, Paris, France. Electronic address: sabri.soussi@aphp.fr.
authors.forename: Sabri
authors.initials: S
authors.lastname: Soussi
authors.affiliation: Department of Anesthesiology and Critical Care and Burn Unit, AP-HP, Hôpital Saint-Louis, Paris, France; UMR INSERM 942, Institut National de la Sante et de la Recherche Medicale (INSERM), Hopital Lariboisiere, Paris, France; Universite Paris Diderot, F-75475, Paris, France. Electronic address: matthieu.legrand@aphp.fr.
authors.forename: Matthieu
authors.initials: M
authors.lastname: Legrand
mesh_terms: D002056:Burns / Q000503:physiopathology / Q000628:therapy*; D004487:Edema / Q000503:physiopathology; D005440:Fluid Therapy; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D008833:Microcirculation / Q000502:physiology; D012769:Shock
keywords: burns; edema; fluid therapy; macrocirculation; microcirculation; shock