title: Troponins, heat shock proteins and glycogen phosphorylase BB in umbilical cord blood of complicated pregnancies.
abstract: OBJECTIVE
  Heat shock proteins (Hsp) are evolutionary conserved molecules with a chaperone role in cell survival. We hypothesized that cord blood concentrations of molecules reflecting fetal cardiac muscle insult, including Hsp, troponins cTnI and cTnT, and glycol-phosphorylase BB (GP-BB) would be elevated in pregnancies complicated by gestational diabetes (GDM) or preeclampsia (PIH) compared to healthy controls.
  
  
  METHODS
  Pregnant women admitted for delivery at >28 weeks were divided into four groups: healthy patients delivered vaginally (VAG), healthy patients delivered by c-section (CS), patients with PIH, and patients with GDM. Demographics, clinical characteristics, and cord blood concentrations of Hsp, troponins cTnI and cTnT, and GP-BB were compared between groups. Statistical analyses included t-test, Chi square, and Wilcoxon rank sum as appropriate.
  
  
  RESULTS
  cTnI concentrations were significantly higher in the PIH group compared to the GDM and VAG groups and they were higher in the CS group compared to the VAG group. Concentrations of Hsp70 were higher in the GDM group compared to the VAG and CS groups. Concentration of GP-BB was higher in the PIH group compared to the VAG group.
  
  
  CONCLUSIONS
  GP-BB and cTNI are the most sensitive markers for PIH-related fetal myocyte injury as is Hsp70 in pregnancies complicated by GDM.
authors.affiliation: a Mountainview Hospital , Las Vegas , NV , USA.
authors.forename: Ana
authors.initials: A
authors.lastname: Mrkaic
authors.affiliation: b Mount Sinai West Hospital , New York , NY , USA.
authors.forename: Barak
authors.initials: B
authors.lastname: Rosenn
authors.affiliation: c Medical Faculty , University of Nis , Nis , Serbia.
authors.forename: Ivana
authors.initials: I
authors.lastname: Stojanovic
authors.affiliation: d Department of Medicine , Rutgers University , Newark , NJ , USA.
authors.forename: Samir
authors.initials: S
authors.lastname: Tivari
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D016640:Diabetes, Gestational / Q000097:blood; D005260:Female; D005312:Fetal Blood / Q000737:chemistry* / Q000378:metabolism; D005333:Fetus / Q000378:metabolism / Q000473:pathology; D024981:Glycogen Phosphorylase / Q000097:blood*; D006360:Heat-Shock Proteins / Q000097:blood*; D006801:Humans; D007231:Infant, Newborn; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D011225:Pre-Eclampsia / Q000097:blood; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood*; D014336:Troponin / Q000097:blood*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D006360:Heat-Shock Proteins; D014336:Troponin; D024981:Glycogen Phosphorylase
keywords: GPBB; Hsp 27; Hsp 70; neonate; troponins