title: Usefulness of 18F-α-Methyltyrosine PET for Therapeutic Monitoring of Patients with Advanced Lung Cancer.
abstract: L-[3-18F]-α-methyl tyrosine (18F-FAMT) positron emission tomography (PET) has a high specificity for detecting malignant lesions. However, the usefulness of therapeutic monitoring of18F-FAMT PET against advanced human neoplasms remains unclear. Here, we evaluated18F-FAMT PET clinical significance regarding therapy response and outcome after systemic chemotherapy in patients with advanced lung cancer, compared to18F-FDG PET.
  
  
  
  All patients with untreated advanced lung cancer received18F-FAMT PET and18F-FDG PET before and 4 weeks after one cycle of chemotherapy. Metabolic response (MR) was defined according to the PERCIST guideline.
  
  
  
  Ninety-five patients were eligible for analysis on both PET scans. The histological type included 87 non-small cell lung cancers and 8 small-cell lung cancers. Post-treatment maximal standardized uptake values (SUVmax) and MR on18F-FAMT PET were correlated with tumor response. In all patients, post-treatment SUVmaxof18F-FDG and18F-FAMT PET and MR of18F-FAMT PET were statistically significant prognostic markers for predicting poor outcome by univariate analysis. Multivariate analysis confirmed that MR on18F-FAMT PET was a significant independent prognostic factor.
  
  
  
  MR on18F-FAMT PET may be a potential parameter to predict the prognosis after first-line chemotherapy in patients with advanced lung cancer.
authors.affiliation: Department of Oncology Clinical Development, Gunma University, Graduate School of Medicine, Gunma, Japan kkaira1970@yahoo.co.jp oriuchi@fmu.ac.jp.|Department of Medicine and Molecular Science, Gunma University, Graduate School of Medicine, Gunma, Japan.
authors.forename: Kyoichi
authors.initials: K
authors.lastname: Kaira
authors.affiliation: Department of Diagnostic Radiology and Nuclear medicine, Gunma University, Graduate School of Medicine, Gunma, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Higuchi
authors.affiliation: Department of Medicine and Molecular Science, Gunma University, Graduate School of Medicine, Gunma, Japan.
authors.forename: Noriaki
authors.initials: N
authors.lastname: Sunaga
authors.affiliation: Department of Diagnostic Radiology and Nuclear medicine, Gunma University, Graduate School of Medicine, Gunma, Japan.
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Arisaka
authors.affiliation: Department of Medicine and Molecular Science, Gunma University, Graduate School of Medicine, Gunma, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Hisada
authors.affiliation: Advanced Clinical Research Center, Fukushima Global Medical Science Center, Fukushima Medical University, Fukushima, Japan.
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Tominaga
authors.affiliation: Advanced Clinical Research Center, Fukushima Global Medical Science Center, Fukushima Medical University, Fukushima, Japan kkaira1970@yahoo.co.jp oriuchi@fmu.ac.jp.
authors.forename: Noboru
authors.initials: N
authors.lastname: Oriuchi
authors.affiliation: Department of Oncology Clinical Development, Gunma University, Graduate School of Medicine, Gunma, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Asao
authors.affiliation: Department of Diagnostic Radiology and Nuclear medicine, Gunma University, Graduate School of Medicine, Gunma, Japan.
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Tsushima
authors.affiliation: Department of Medicine and Molecular Science, Gunma University, Graduate School of Medicine, Gunma, Japan.
authors.forename: Masanobu
authors.initials: M
authors.lastname: Yamada
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D005260:Female; D005462:Fluorine Radioisotopes / Q000008:administration & dosage*; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy; D008297:Male; D008781:Methyltyrosines / Q000008:administration & dosage*; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods*
chemical_list: D000970:Antineoplastic Agents; D005462:Fluorine Radioisotopes; D008781:Methyltyrosines
keywords: 18F-FAMT; PET; lung cancer; metabolic response; therapeutic monitoring