title: A randomised clinical in situ study to evaluate the effects of novel low abrasivity anti-sensitivity dentifrices on dentine wear.
abstract: OBJECTIVE
  To compare the abrasive wear on human dentine in an in situ model associated with use of an experimental low abrasivity anti-sensitivity dentifrice containing 1% alumina and 5% sodium tripolyphosphate (STP) with an experimental ultra-low abrasivity non-alumina 5% STP dentifrice, a higher abrasivity daily-use whitening dentifrice, and water as controls.
  
  
  METHODS
  This was a single-centre, single-blind, randomised, split-mouth, four-treatment, two-period, crossover in situ study in 29 healthy subjects. Subjects wore bilateral lower buccal appliances, each fitted with four dentine specimens. Study treatments were applied ex vivo (three times daily). Dentine loss was measured by non-contact profilometry after 5, 10 and 15days' treatment.
  
  
  RESULTS
  All 29 subjects were included in the efficacy analysis. Significantly less dentine loss was associated with brushing with the low and ultra-low abrasivity dentifrices than with the higher abrasivity dentifrice at all timepoints (p<0.01). Brushing with ultra-low abrasivity dentifrice or water resulted in statistically significantly less dentine loss compared with brushing with the low abrasivity dentifrice at all timepoints (p<0.05). Dentine loss after brushing with ultra-low abrasivity dentifrice was not significantly different from brushing with water.
  
  
  CONCLUSIONS
  The degree of dentine loss observed in this in situ model reflected the abrasivity of the study dentifrices. Brushing with low or ultra-low abrasivity STP-containing anti-sensitivity dentifrices resulted in significantly less dentine loss (equating to dentine wear) than with a higher abrasivity daily-use whitening dentifrice.
authors.affiliation: Periodontology Clinical Trials Unit, Bristol Dental School, Bristol, UK.
authors.forename: J
authors.initials: J
authors.lastname: Seong
authors.affiliation: GSK Consumer Healthcare, Weybridge, Surrey, UK.
authors.forename: C
authors.initials: C
authors.lastname: Hall
authors.affiliation: GSK Consumer Healthcare, Weybridge, Surrey, UK.
authors.forename: S
authors.initials: S
authors.lastname: Young
authors.affiliation: GSK Consumer Healthcare, Weybridge, Surrey, UK.
authors.forename: C
authors.initials: C
authors.lastname: Parkinson
authors.affiliation: Periodontology Clinical Trials Unit, Bristol Dental School, Bristol, UK.
authors.forename: E
authors.initials: E
authors.lastname: Macdonald
authors.affiliation: Periodontology Clinical Trials Unit, Bristol Dental School, Bristol, UK.
authors.forename: S Bodfel
authors.initials: SB
authors.lastname: Jones
authors.affiliation: Periodontology Clinical Trials Unit, Bristol Dental School, Bristol, UK. Electronic address: n.x.west@bristol.ac.uk.
authors.forename: N X
authors.initials: NX
authors.lastname: West
mesh_terms: D000328:Adult; D000537:Aluminum Oxide / Q000494:pharmacology / Q000627:therapeutic use; D018592:Cross-Over Studies; D003743:Dental Enamel / Q000187:drug effects*; D003802:Dentifrices / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D003804:Dentin / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011122:Polyphosphates / Q000494:pharmacology / Q000627:therapeutic use; D016037:Single-Blind Method; D013997:Time Factors; D014072:Tooth Abrasion / Q000188:drug therapy*; D014077:Tooth Erosion / Q000188:drug therapy; D057085:Tooth Wear / Q000188:drug therapy*; D014099:Toothbrushing / Q000379:methods; D014100:Toothpastes / Q000494:pharmacology / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D003802:Dentifrices; D011122:Polyphosphates; D014100:Toothpastes; D000537:Aluminum Oxide; C005692:triphosphoric acid
keywords: Abrasivity; Alumina; Dentifrice; Dentine; Profilometry; Sodium tripolyphosphate