title: Measuring Mean Cup Depth in the Optic Nerve Head.
abstract: Since the deformation of structures in the optic nerve head (ONH) is associated with glaucoma and other diseases of the optic nerve, measurement of this deformation is of current research interest. This paper considers the computation of cup depth, a measurement of the depth of the internal limiting membrane (ILM). The computation of cup depth requires a reference structure against which to measure the ILM, and the construction of two reference structures is discussed, one based on Bruch's membrane opening (BMO) and the other based on the anterior surface of the peripapillary sclera (AS). A main focus of the paper is the robust computation of mean cup depth, which requires a good sampling of a reconstruction of the ILM surface. To evaluate our algorithm, the construction of synthetic datasets is considered.
authors.affiliation: Department of Computer and Information Sciences, UAB, jkj@uab.edu; Department of Ophthalmology, UAB.
authors.forename: John K
authors.initials: JK
authors.lastname: Johnstone
authors.affiliation: Department of Ophthalmology, UAB.
authors.forename: Lindsay
authors.initials: L
authors.lastname: Rhodes
authors.affiliation: Department of Ophthalmology, UAB.
authors.forename: Massimo
authors.initials: M
authors.lastname: Fazio
authors.affiliation: Department of Ophthalmology, UAB.
authors.forename: Brandon
authors.initials: B
authors.lastname: Smith
authors.affiliation: Department of Ophthalmology, UAB.
authors.forename: Lan
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Ophthalmology, UAB.
authors.forename: J Crawford
authors.initials: JC
authors.lastname: Downs
authors.affiliation: Department of Ophthalmology, UAB.
authors.forename: Cynthia
authors.initials: C
authors.lastname: Owsley
authors.affiliation: Department of Ophthalmology, UAB.
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Girkin
keywords: Morphometry; cup depth; meshing; reference structure; sampling