title: Design and Synthesis of 1,4-dihydropyridine Derivatives as Anti-cancer Agent.
abstract: OBJECTIVE
  A series of 1,4-dihydropyridine based compounds bearing benzylpyridinium moiety have been designed and evaluated for in vitro anticancer activity against glioblastoma U87MG, lung cancer A549 and colorectal adenocarcinoma Caco-2 cell lines using the MTT assay.
  
  
  METHODS
  Among these compounds, 7b, 7d, 7e, and 7f exhibited potent anticancer activity against the cell lines tested. The cytotoxicity of the synthesized derivatives was compared to standard drugs (carboplatin, gemcitabine, and daunorubicin).
  
  
  RESULTS
  Thus, synthesized 1,4-dihydropyridines can be considered as the encouraging molecules for further drug development as anticancer agents.
authors.affiliation: Center of Excellence, National Facility for Drug Discovery Center, Department of Chemistry, Saurashtra University, Rajkot, India.
authors.forename: Denish
authors.initials: D
authors.lastname: Viradiya
authors.affiliation: bDepartment of Life Science, School of Science, Gujarat University, Gujarat, India.
authors.forename: Sheefa
authors.initials: S
authors.lastname: Mirza
authors.affiliation: Center of Excellence, National Facility for Drug Discovery Center, Department of Chemistry, Saurashtra University, Rajkot, India.
authors.forename: Faraz
authors.initials: F
authors.lastname: Shaikh
authors.affiliation: Center of Excellence, National Facility for Drug Discovery Center, Department of Chemistry, Saurashtra University, Rajkot, India.
authors.forename: Rajesh
authors.initials: R
authors.lastname: Kakadiya
authors.affiliation: Center of Excellence, National Facility for Drug Discovery Center, Department of Chemistry, Saurashtra University, Rajkot, India.
authors.forename: Anand
authors.initials: A
authors.lastname: Rathod
authors.affiliation: Department of Life Science, School of Science, Gujarat University, Gujarat, India.
authors.forename: Nayan
authors.initials: N
authors.lastname: Jain
authors.affiliation: Gujarat Cancer Research Institute, Asarwa, Ahmedabad, Gujarat, India.
authors.forename: Rakesh
authors.initials: R
authors.lastname: Rawal
authors.affiliation: Center of Excellence, National Facility for Drug Discovery Center, Department of Chemistry, Saurashtra University, Rajkot, India.
authors.forename: Anamik
authors.initials: A
authors.lastname: Shah
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects*; D004095:Dihydropyridines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D004095:Dihydropyridines; C038806:1,4-dihydropyridine
keywords: 1; 4-dihydropyridine; Anticancer activity; MTT assay; antipoliferative activity; benzylpyridinium salt