title: Trigonella foenum-graecum alleviates airway inflammation of allergic asthma in ovalbumin-induced mouse model.
abstract: Trigonella foenum-graecum, a member oldest medicinal plant in the fabaceae (legumes) family, is used as a herb, spice, and vegetable, and known for its olfactory, laxative, and galactogogue effects. However, the inhibitory effect of Trigonella foenum-graecum on allergic inflammatory response remains unclear, therefore, we investigated the precise role of Trigonella foenum-graecum in the allergic asthma and revealed the effects of Trigonella foenum-graecum in regulating airway inflammation and its possible mechanism. Allergic asthma was initiated in BALB/c mice by sensitized with OVA emulsified in aluminum on days 1 and 14, then aerosol challenged with OVA on days 27, 28 and 29. Some mice were administered Trigonella foenum-graecum by oral gavage before challenge. Then mice were evaluated for the presence of airway inflammation, production of allergen-specific cytokine response and lung pathology. Trigonella foenum-graecum significantly ameliorated the number of inflammatory cells in BALF and alleviated lung inflammation. It also reduced the collagen deposition and goblet cells. Meanwhile, Trigonella foenum-graecum treatment evidently decreased the high expression of Th2 cytokines and increased the Th1 cytokines in BALF and lung homogenates. Trigonella foenum-graecum showed a significant inhibition of serum IgE and anti-OVA IgG1.In this study, our data suggest that Trigonella foenum-graecum has a significant anti-inflammatory effect and it may prove to be an efficacious therapeutic regent on allergic asthma.
authors.affiliation: Department of Anatomy, Chonbuk National University Medical School, Jeonju, Jeonbuk, 54896, Republic of Korea.
authors.forename: Chun Hua
authors.initials: CH
authors.lastname: Piao
authors.affiliation: Department of Anatomy, Chonbuk National University Medical School, Jeonju, Jeonbuk, 54896, Republic of Korea.
authors.forename: Thi Tho
authors.initials: TT
authors.lastname: Bui
authors.affiliation: Department of Anatomy, Chonbuk National University Medical School, Jeonju, Jeonbuk, 54896, Republic of Korea; Institute for Medical Sciences, Chonbuk National University, Jeonju, Jeonbuk, 54896, Republic of Korea.
authors.forename: Chang Ho
authors.initials: CH
authors.lastname: Song
authors.affiliation: Food Biotechnology Program, Korea University of Science and Technology, Daejeon 305-350, Republic of Korea; Division of Nutrition and Metabolism Research, Korea Food Research Institute, Bundang-gu, Seongnam-si, Kyeonggi-do 463-746, Republic of Korea.
authors.forename: Hee Soon
authors.initials: HS
authors.lastname: Shin
authors.affiliation: Food Biotechnology Program, Korea University of Science and Technology, Daejeon 305-350, Republic of Korea; Division of Functional Food Research, Korea Food Research Institute, Bundang-gu, Seongnam-si, Kyeonggi-do 463-746, Republic of Korea.
authors.forename: Dong-Hwa
authors.initials: DH
authors.lastname: Shon
authors.affiliation: Department of Anatomy, Chonbuk National University Medical School, Jeonju, Jeonbuk, 54896, Republic of Korea; Institute for Medical Sciences, Chonbuk National University, Jeonju, Jeonbuk, 54896, Republic of Korea. Electronic address: okchai1004@jbnu.ac.kr.
authors.forename: Ok Hee
authors.initials: OH
authors.lastname: Chai
mesh_terms: D000485:Allergens / Q000737:chemistry; D000818:Animals; D001249:Asthma / Q000188:drug therapy*; D001992:Bronchoalveolar Lavage Fluid; D016207:Cytokines / Q000276:immunology; D004195:Disease Models, Animal; D006967:Hypersensitivity / Q000188:drug therapy*; D007073:Immunoglobulin E / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D007249:Inflammation / Q000188:drug therapy; D008168:Lung / Q000378:metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin; D010936:Plant Extracts / Q000494:pharmacology*; D018418:Th2 Cells / Q000276:immunology; D029910:Trigonella / Q000737:chemistry*
chemical_list: D000485:Allergens; D016207:Cytokines; D007074:Immunoglobulin G; D010936:Plant Extracts; D007073:Immunoglobulin E; D010047:Ovalbumin
keywords: Airway inflammation; Asthma; Th2 cytokines; Trigonella foenum-graecum