title: Insights into the post-transcriptional regulation of the mitochondrial electron transport chain.
abstract: The regulation of the mitochondrial electron transport chain is central to the control of cellular homeostasis. There are significant gaps in our understanding of how the expression of the mitochondrial and nuclear genome-encoded components of the electron transport chain are co-ordinated, and how the assembly of the protein complexes that constitute the electron transport chain are regulated. Furthermore, the role post-transcriptional gene regulation may play in modulating these processes needs to be clarified. This review summarizes the current knowledge regarding the post-transcriptional gene regulation of the electron transport chain and highlights how noncoding RNAs may contribute significantly both to complex electron transport chain regulatory networks and to mitochondrial dysfunction.
authors.affiliation: Institute of Genetics and Molecular Medicine, MRC Human Genetics Unit, University of Edinburgh, Edinburgh, U.K.|Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, U.K.
authors.forename: Tamara M
authors.initials: TM
authors.lastname: Sirey
authors.affiliation: Institute of Genetics and Molecular Medicine, MRC Human Genetics Unit, University of Edinburgh, Edinburgh, U.K.
authors.forename: Chris P
authors.initials: CP
authors.lastname: Ponting
mesh_terms: D000818:Animals; D004272:DNA, Mitochondrial / Q000235:genetics*; D004579:Electron Transport / Q000235:genetics; D005786:Gene Expression Regulation; D006801:Humans; D008928:Mitochondria / Q000235:genetics* / Q000378:metabolism; D008957:Models, Genetic; D010085:Oxidative Phosphorylation; D012313:RNA / Q000235:genetics* / Q000378:metabolism; D000077278:RNA, Mitochondrial; D016601:RNA-Binding Proteins / Q000378:metabolism
chemical_list: D004272:DNA, Mitochondrial; D000077278:RNA, Mitochondrial; D016601:RNA-Binding Proteins; D012313:RNA
keywords: RNA-binding proteins; eukaryotic gene expression; metabolic regulation; microRNA; mitochondrial respiration