title: The prognostic role of pretreatment platelet-to-lymphocyte ratio as predictors in patients with colorectal cancer: a meta-analysis.
abstract: OBJECTIVE
  This meta-analysis was designed to analyze and evaluate the prognostic role of preoperative or pretreatment platelet-to-lymphocyte ratio (PLR) in patients with colorectal cancer (CRC).
  
  
  METHODS
  We searched PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, Chinese Biomedical Literature Database and WanFang Database up to April 2016.
  
  
  RESULTS
  A total of 16 studies (n = 5068 participants) were included for this meta-analysis. Elevated PLR has a close relationship with the poor overall survival of CRC, with the pooled hazard ratio being 1.88 (95% CI: 1.50, 2.36; p < 0.00001).
  
  
  CONCLUSIONS
  This meta-analysis indicated that pretreatment PLR may be a cost-effective and noninvasive serum biomarker for poor prognosis for patients with CRC.
authors.affiliation: Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou 730000, China.
authors.forename: Guang-Tao
authors.initials: GT
authors.lastname: Min
authors.affiliation: Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou 730000, China.|The First Clinical Medical College of Lanzhou University, Lanzhou 730000, China.|Department of General Surgery, Qinghai University Affiliated Hospital, Xi'ning 810000, China.
authors.forename: Yong-Hong
authors.initials: YH
authors.lastname: Wang
authors.affiliation: Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou 730000, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Yao
authors.affiliation: Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou 730000, China.|The First Clinical Medical College of Lanzhou University, Lanzhou 730000, China.
authors.forename: Jian-Meng
authors.initials: JM
authors.lastname: Zhao
authors.affiliation: Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou 730000, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou 730000, China.
authors.forename: Hong-Peng
authors.initials: HP
authors.lastname: Wang
authors.affiliation: Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou 730000, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.affiliation: Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou 730000, China.|The First Clinical Medical College of Lanzhou University, Lanzhou 730000, China.
authors.forename: Shao-Jun
authors.initials: SJ
authors.lastname: Deng
authors.affiliation: Department of general Surgery, Lanzhou University Second Hospital, Lanzhou 730000, China.
authors.forename: Yu-Min
authors.initials: YM
authors.lastname: Li
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D001792:Blood Platelets / Q000166:cytology*; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology; D016208:Databases, Factual; D018572:Disease-Free Survival; D006801:Humans; D018655:Lymphocyte Count; D008214:Lymphocytes / Q000166:cytology*; D010976:Platelet Count; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models; D015996:Survival Rate
chemical_list: D015415:Biomarkers
keywords: biomarker; colorectal cancer; meta-analysis; platelet; platelet-to-lymphocyte ratio; prognosis