title: Genetic variability in the system of natriuretic B peptide and principal toxicological parameters in workers exposed to lead.
abstract: The study was aimed at evaluating the influence of selected polymorphisms of natriuretic peptide B precursor (NPPB) and natriuretic peptide receptor C (NPR3) genes on blood lead concentration (Pb-B) and blood zinc protoporphyrin concentration (ZnPP) in persons occupationally exposed to lead. Investigations were conducted on 360 persons (mean age: 44.49±9.62years), workers exposed to lead compounds. The analysis examined four polymorphisms of BNP gene, i.e.,: rs198388, rs198389, rs632793, and rs6676300; as well as one polymorphism of receptor C for natriuretic peptides, i.e., rs1421811. Heterozygosity in locus rs632793 of NPPB gene may result in higher concentrations of Pb-B, while allele A in locus rs632793 of NPPB gene seems to determine higher concentrations of ZnPP in persons occupationally exposed to lead. Workers exposed to lead and carrying allele C in locus rs198388 of NPPB gene, particularly in the heterozygotic setup, seem to be predisposed to present higher concentrations of ZnPP. Carriership of A allele in locus rs198389 of NPPB gene probably determines higher concentrations of ZnPP in study group. In summary, among persons occupationally exposed to lead, certain relationships were demonstrated between rs632793, rs198388 and rs198389 polymorphisms of NPPB gene and principal toxicological parameters characterizing exposure to lead.
authors.affiliation: Department of Internal Medicine, Occupational Diseases and Hypertension, Wroclaw Medical University, Borowska 213, PL 50-556 Wroclaw, Poland.
authors.forename: Marta
authors.initials: M
authors.lastname: Jurdziak
authors.affiliation: Department of Internal Medicine, Occupational Diseases and Hypertension, Wroclaw Medical University, Borowska 213, PL 50-556 Wroclaw, Poland; Department of Hygiene, Wroclaw Medical University, Mikulicza-Radeckiego 7, PL 50-368 Wroclaw, Poland. Electronic address: pawelgac@interia.pl.
authors.forename: Paweł
authors.initials: P
authors.lastname: Gać
authors.affiliation: Department of Internal Medicine, Occupational Diseases and Hypertension, Wroclaw Medical University, Borowska 213, PL 50-556 Wroclaw, Poland.
authors.forename: Rafał
authors.initials: R
authors.lastname: Poręba
authors.affiliation: Department of Pathophysiology, Wroclaw Medical University, Marcinkowskiego 1, PL 50-368 Wroclaw, Poland.
authors.forename: Marzena
authors.initials: M
authors.lastname: Gonerska
authors.affiliation: Department of Pathophysiology, Wroclaw Medical University, Marcinkowskiego 1, PL 50-368 Wroclaw, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Jonkisz
authors.affiliation: Department of Pathophysiology, Wroclaw Medical University, Marcinkowskiego 1, PL 50-368 Wroclaw, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Gromek
authors.affiliation: Department of Pathophysiology, Wroclaw Medical University, Marcinkowskiego 1, PL 50-368 Wroclaw, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Poręba
authors.affiliation: Department of Internal Medicine, Occupational Diseases and Hypertension, Wroclaw Medical University, Borowska 213, PL 50-556 Wroclaw, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Szymańska-Chabowska
authors.affiliation: Department of Internal Medicine, Occupational Diseases and Hypertension, Wroclaw Medical University, Borowska 213, PL 50-556 Wroclaw, Poland.
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Mazur
authors.affiliation: Department of Pathophysiology, Wroclaw Medical University, Marcinkowskiego 1, PL 50-368 Wroclaw, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Sobieszczańska
mesh_terms: D000328:Adult; D000395:Air Pollutants, Occupational / Q000097:blood / Q000633:toxicity / Q000652:urine; D001151:Arsenic / Q000652:urine; D009320:Atrial Natriuretic Factor / Q000235:genetics*; D004784:Environmental Monitoring; D005260:Female; D006801:Humans; D008297:Male; D019216:Metals, Heavy / Q000097:blood / Q000633:toxicity / Q000652:urine; D008875:Middle Aged; D016273:Occupational Exposure / Q000032:analysis*; D020641:Polymorphism, Single Nucleotide; D011524:Protoporphyrins / Q000097:blood; D017461:Receptors, Atrial Natriuretic Factor / Q000235:genetics; D055815:Young Adult
chemical_list: D000395:Air Pollutants, Occupational; D019216:Metals, Heavy; D011524:Protoporphyrins; C017803:zinc protoporphyrin; D009320:Atrial Natriuretic Factor; D017461:Receptors, Atrial Natriuretic Factor; C073616:atrial natriuretic factor receptor C; D001151:Arsenic
keywords: Blood lead concentration; Blood zinc protoporphyrin concentration; Natriuretic peptide B precursor; Natriuretic peptide receptor C; Single-nucleotide polymorphism