title: The spatiotemporal regulation of RAS signalling.
abstract: Nearly 30% of human tumours harbour mutations in RAS family members. Post-translational modifications and the localisation of RAS within subcellular compartments affect RAS interactions with regulator, effector and scaffolding proteins. New insights into the control of spatiotemporal RAS signalling reveal that activation kinetics and subcellular compartmentalisation are tightly coupled to the generation of specific biological outcomes. Computational modelling can help utilising these insights for the identification of new targets and design of new therapeutic approaches.
authors.affiliation: Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland.
authors.forename: Ana
authors.initials: A
authors.lastname: Herrero
authors.affiliation: Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland.|School of Medicine, University College Dublin, Belfield, Dublin 4, Ireland.
authors.forename: David
authors.initials: D
authors.lastname: Matallanas
authors.affiliation: Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland.|School of Medicine, University College Dublin, Belfield, Dublin 4, Ireland.|Conway Institute of Biomolecular & Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland.
authors.forename: Walter
authors.initials: W
authors.lastname: Kolch
mesh_terms: D000818:Animals; D002451:Cell Compartmentation; D020558:GTP Phosphohydrolases / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D008954:Models, Biological; D011499:Protein Processing, Post-Translational; D021381:Protein Transport; D016283:Proto-Oncogene Proteins p21(ras) / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: C117307:KRAS protein, human; D008565:Membrane Proteins; D020558:GTP Phosphohydrolases; C579846:NRAS protein, human; C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras)
keywords: RAS; cellular localisation; site-specific signalling