title: Correlation of West Nile Virus Incidence in Donated Blood with West Nile Neuroinvasive Disease Rates, United States, 2010-2012.
abstract: Over the past decade, West Nile virus (WNV) has spread across the United States. We aggregated blood donor data from 2010-2012 and then calculated the incidence of WNV RNA-positive donations and compared the incidence with neuroinvasive disease (NID) case data from the ArboNET surveillance system. Of 10,107,853 donations, 640 were confirmed positive. The seasonal WNV incidence rate per 100,000 persons was 33.4 (95% CI 22-45) in 2010, 25.7 (95% CI 15-34) in 2011, and 119.9 (95% CI 98-141) in 2012. NID to blood donor ratios were 1 in 164 (95% CI 152-178) in 2010, 1 in 158 (95% CI 145-174) in 2011, and 1 in 131 (95% CI 127-136) in 2012. We updated estimates of the ratio of NID to WNV infection rates, demonstrating stable disease penetrance over the study period. Blood donor WNV RNA screening is a valuable public health tool for WNV surveillance.
authors.forename: Edouard
authors.initials: E
authors.lastname: Betsem
authors.forename: Zhanna
authors.initials: Z
authors.lastname: Kaidarova
authors.forename: Susan L
authors.initials: SL
authors.lastname: Stramer
authors.forename: Beth
authors.initials: B
authors.lastname: Shaz
authors.forename: Merlyn
authors.initials: M
authors.lastname: Sayers
authors.forename: German
authors.initials: G
authors.lastname: LeParc
authors.forename: Brian
authors.initials: B
authors.lastname: Custer
authors.forename: Michael P
authors.initials: MP
authors.lastname: Busch
authors.forename: Edward L
authors.initials: EL
authors.lastname: Murphy
mesh_terms: D001782:Blood Donors; D016208:Databases, Factual; D062306:Geography, Medical; D049674:History, 21st Century; D006801:Humans; D015994:Incidence; D011159:Population Surveillance; D012367:RNA, Viral; D012621:Seasons; D062211:Spatio-Temporal Analysis; D014481:United States / Q000453:epidemiology; D014901:West Nile Fever / Q000453:epidemiology* / Q000266:history / Q000635:transmission* / Q000821:virology; D014902:West Nile virus / Q000235:genetics
chemical_list: D012367:RNA, Viral
keywords: United States; WNV; West Nile virus; antibodies; arbovirus; blood donors; demographic factors; geographic variation; incidence; neuroinvasive disease; nucleic acid testing; seasonal variation; surveillance; vector-borne infections; viruses; zoonoses