title: Construction of A Triple-Stimuli-Responsive System Based on Cerium Oxide Coated Mesoporous Silica Nanoparticles.
abstract: In this work, a triple-stimuli (GSH, pH and light irradiation) responsive system were designed based on CeO2nanoparticles (CeO2NPs) coated doxorubicin (DOX) and photosensitizer hematoporphyrin (HP) dual-loaded mesoporous silica nanoparticles (MSN). Upon entering into cancer cells, both high concentration of intracellular GSH and low pH environment would reduce CeO2NPs to cerium ions, accompanied with the degradation of CeO2NPs and the conformational change of HP under light irradiation, the preloaded DOX are thus released from the nanocarrier, resulting in a contrast fluorescence enhancement. Meanwhile,1O2generated from HP for potential photodynamic therapy (PDT) upon light irradiation. In comparison, not much influence can be observed for normal cells. This nanosystem not only has a significantly enhanced efficacy for cancer cells but also broad the scope for the future design and applications of multifunctional platforms for synergetic chemotherapy and PDT.
authors.affiliation: Shaanxi Key Laboratory of Natural Products &Chemical Biology, College of Science, Northwest A&F University, Yangling, Shaanxi 712100, People's Republic of China.
authors.forename: Jia
authors.initials: J
authors.lastname: Wen
authors.affiliation: Shaanxi Key Laboratory of Natural Products &Chemical Biology, College of Science, Northwest A&F University, Yangling, Shaanxi 712100, People's Republic of China.
authors.forename: Kui
authors.initials: K
authors.lastname: Yang
authors.affiliation: Shaanxi Key Laboratory of Natural Products &Chemical Biology, College of Science, Northwest A&F University, Yangling, Shaanxi 712100, People's Republic of China.
authors.forename: Yongqian
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Shaanxi Key Laboratory of Natural Products &Chemical Biology, College of Science, Northwest A&F University, Yangling, Shaanxi 712100, People's Republic of China.
authors.forename: Hongjuan
authors.initials: H
authors.lastname: Li
authors.affiliation: State Key Laboratory of Fine Chemicals, School of Chemistry, Dalian University of Technology, No.2 linggong Road, Ganjingzi, District, Dalian 116023, People's Republic of China.
authors.forename: Fengyu
authors.initials: F
authors.lastname: Liu
authors.affiliation: Shaanxi Key Laboratory of Natural Products &Chemical Biology, College of Science, Northwest A&F University, Yangling, Shaanxi 712100, People's Republic of China.
authors.forename: Shiguo
authors.initials: S
authors.lastname: Sun