title: Lassa Virus Cell Entry Reveals New Aspects of Virus-Host Cell Interaction.
abstract: Viral entry represents the first step of every viral infection and is a determinant for the host range and disease potential of a virus. Here, we review the latest developments on cell entry of the highly pathogenic Old World arenavirus Lassa virus, providing novel insights into the complex virus-host cell interaction of this important human pathogen. We will cover new discoveries on the molecular mechanisms of receptor recognition, endocytosis, and the use of late endosomal entry factors.
authors.affiliation: Institute of Microbiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
authors.forename: Giulia
authors.initials: G
authors.lastname: Torriani
authors.affiliation: Institute of Microbiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
authors.forename: Clara
authors.initials: C
authors.lastname: Galan-Navarro
authors.affiliation: Institute of Microbiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland Stefan.Kunz@chuv.ch.
authors.forename: Stefan
authors.initials: S
authors.lastname: Kunz
mesh_terms: D000818:Animals; D049030:Dystroglycans / Q000378:metabolism; D004705:Endocytosis; D011992:Endosomes / Q000378:metabolism / Q000821:virology; D054884:Host-Pathogen Interactions; D006801:Humans; D007835:Lassa Fever / Q000378:metabolism / Q000821:virology*; D007836:Lassa virus / Q000502:physiology*; D052118:Lysosomal-Associated Membrane Protein 1 / Q000378:metabolism; D010873:Pinocytosis; D011991:Receptors, Virus / Q000378:metabolism; D056189:Viral Tropism; D053586:Virus Internalization
chemical_list: D052118:Lysosomal-Associated Membrane Protein 1; D011991:Receptors, Virus; D049030:Dystroglycans
keywords: Lassa fever; endocytosis; late endosome; receptor; viral entry