title: PDGFA Makes Thin Skin Thicker: Molecular Regulation of Adipose Progenitor Maintenance.
abstract: Adipocyte progenitor proliferation and self-renewal contribute to adipose tissue maintenance; however, the regulatory circuits of these processes are less understood. In this issue of Cell Stem Cell, Rivera-Gonzalez et al. (2016) show that PDGFA, which acts through PI3K-Akt pathways, plays a vital role in the proliferation and maintenance of adipocyte progenitors in dermal adipose tissues.
authors.affiliation: UCSF Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: skajimura@diabetes.ucsf.edu.
authors.forename: Shingo
authors.initials: S
authors.lastname: Kajimura
mesh_terms: D017667:Adipocytes; D000273:Adipose Tissue; D002454:Cell Differentiation; D049109:Cell Proliferation; D006801:Humans; D019869:Phosphatidylinositol 3-Kinases; D013234:Stem Cells
chemical_list: D019869:Phosphatidylinositol 3-Kinases