title: Thermally Induced [3 + 2] Cycloaddition of Alkynyl-Tethered Diazoamides: Synthetic and Mechanistic Insights.
abstract: A general and unprecedented thermally induced formal [3 + 2] cycloaddition has been developed that provides a general access to fused lactam derivatives in high to excellent yields with broad substrate scope. In comparison with the reported metal-catalyzed carbene/alkynyl metathesis, this is the only example in this area under catalyst-free conditions with excellent selectivity. Mechanistic studies indicate that the 3H-pyrazole is the key intermediate in this cascade reaction, which is confirmed spectroscopically for the first time.
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Soochow University , Suzhou 215123, P. R. China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Zhang
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Soochow University , Suzhou 215123, P. R. China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Huang
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Soochow University , Suzhou 215123, P. R. China.
authors.forename: Lihua
authors.initials: L
authors.lastname: Qiu
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Soochow University , Suzhou 215123, P. R. China.
authors.forename: Xinfang
authors.initials: X
authors.lastname: Xu