title: Improvements to the Practical Usability of the "Crystalline Sponge" Method for Organic Structure Determination.
abstract: A microwell droplet approach provided high-quality samples in ≥90% yield of the "crystalline sponge", which was exhibited previously as a revolutionary organic structure determination method. The new protocol, from crystal growth to guest soaking, was conducted in 1-7 days (depending on the guest) and was robust toward user errors, marking improvements over existing protocols. Unit cell determination was used as a practical crystal screening metric. These advances improve the practicality of the crystalline sponge technique for characterizing unknown organic molecules.
authors.affiliation: Department of Chemistry, University of Illinois at Chicago , 845 West Taylor Street, Chicago, Illinois 60607, United States.
authors.forename: Greyson W
authors.initials: GW
authors.lastname: Waldhart
authors.affiliation: Department of Chemistry, University of Illinois at Chicago , 845 West Taylor Street, Chicago, Illinois 60607, United States.
authors.forename: Neal P
authors.initials: NP
authors.lastname: Mankad
authors.affiliation: Center for Natural Product Technologies and Department of Medicinal Chemistry & Pharmacognosy, University of Illinois at Chicago , 833 South Wood Street, Chicago, Illinois 60612, United States.|Center for Biomolecular Sciences, University of Illinois at Chicago , 900 South Ashland Avenue, Chicago, Illinois 60607, United States.
authors.forename: Bernard D
authors.initials: BD
authors.lastname: Santarsiero
mesh_terms: D002725:Chloroform / Q000737:chemistry*; D018360:Crystallography, X-Ray; D003510:Cyclohexanes / Q000737:chemistry*; D008958:Models, Molecular; D009573:Nitrites / Q000737:chemistry*; D010316:Particle Size
chemical_list: D003510:Cyclohexanes; D009573:Nitrites; C506365:Cyclohexane; D002725:Chloroform