title: Resistant Maltodextrin Decreases Micellar Solubility of Lipids and Diffusion of Bile Salt Micelles and Suppresses Incorporation of Micellar Fatty Acids into Caco-2 Cells.
abstract: Several studies have suggested that resistant maltodextrin (RMD) suppresses intestinal lipid absorption in experimental animals and humans. However, possible mechanisms underlying this effect are not known. In this study, effects of RMD on processes of the absorption of various lipids were investigated in vitro. RMD dose-dependently suppressed the solubility of various lipid components, including 1-mono-oleoylglycerol, oleic acid, and phosphatidylcholine in bile salt micelles in vitro. When the diffusion rate of bile salt micelles through a filter membrane was investigated in vitro, bile salt micelles containing RMD diffused more slowly than those without RMD. Incorporation of [1-14C] oleic acid into Caco-2 cells from the RMD-containing bile salt micelles was significantly smaller than that from the control micelles (without RMD). These results show that RMD suppresses intestinal absorption of lipids by decreasing their micellar solubility and the diffusion rate of bile salt micelles.
authors.affiliation: Laboratory of Food and Biomolecular Science, Graduate School of Agricultural Science, Tohoku University.
authors.forename: Ikuo
authors.initials: I
authors.lastname: Ikeda
authors.forename: Kyouhei
authors.initials: K
authors.lastname: Tamakuni
authors.forename: Tomomi
authors.initials: T
authors.lastname: Sakuma
authors.forename: Ran
authors.initials: R
authors.lastname: Ozawa
authors.forename: Nao
authors.initials: N
authors.lastname: Inoue
authors.forename: Yuka
authors.initials: Y
authors.lastname: Kishimoto
mesh_terms: D001647:Bile Acids and Salts / Q000737:chemistry*; D018938:Caco-2 Cells; D002454:Cell Differentiation; D005227:Fatty Acids / Q000737:chemistry*; D005989:Glycerides / Q000737:chemistry; D006801:Humans; D007408:Intestinal Absorption; D008823:Micelles; D019301:Oleic Acid / Q000737:chemistry; D010713:Phosphatidylcholines / Q000737:chemistry; D011134:Polysaccharides / Q000737:chemistry*; D012995:Solubility; D014280:Triglycerides / Q000737:chemistry
chemical_list: D001647:Bile Acids and Salts; D005227:Fatty Acids; D005989:Glycerides; D008823:Micelles; D010713:Phosphatidylcholines; D011134:Polysaccharides; D014280:Triglycerides; D019301:Oleic Acid; C008315:maltodextrin; C005953:monoolein