title: The effect of exposure to nanoparticles and nanomaterials on the mammalian epigenome.
abstract: Human exposure to nanomaterials and nanoparticles is increasing rapidly, but their effects on human health are still largely unknown. Epigenetic modifications are attracting ever more interest as possible underlying molecular mechanisms of gene-environment interactions, highlighting them as potential molecular targets following exposure to nanomaterials and nanoparticles. Interestingly, recent research has identified changes in DNA methylation, histone post-translational modifications, and noncoding RNAs in mammalian cells exposed to nanomaterials and nanoparticles. However, the challenge for the future will be to determine the molecular pathways driving these epigenetic alterations, the possible functional consequences, and the potential effects on health.
authors.affiliation: Cancer Epigenetics Laboratory, Institute of Oncology of Asturias (IUOPA), Hospital Universitario Central de Asturias (HUCA), Universidad de Oviedo, Oviedo.
authors.forename: M I
authors.initials: MI
authors.lastname: Sierra
authors.affiliation: Nanomaterials and Nanotechnology Research Center (CINN-CSIC), Universidad de Oviedo-Principado de Asturias, El Entrego, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Valdés
authors.affiliation: Cancer Epigenetics Laboratory, Institute of Oncology of Asturias (IUOPA), Hospital Universitario Central de Asturias (HUCA), Universidad de Oviedo, Oviedo.
authors.forename: A F
authors.initials: AF
authors.lastname: Fernández
authors.affiliation: Nanomaterials and Nanotechnology Research Center (CINN-CSIC), Universidad de Oviedo-Principado de Asturias, El Entrego, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Torrecillas
authors.affiliation: Nanomaterials and Nanotechnology Research Center (CINN-CSIC), Universidad de Oviedo-Principado de Asturias, El Entrego, Spain.
authors.forename: M F
authors.initials: MF
authors.lastname: Fraga
mesh_terms: D000818:Animals; D019175:DNA Methylation / Q000187:drug effects / Q000235:genetics; D004781:Environmental Exposure / Q000009:adverse effects*; D044127:Epigenesis, Genetic / Q000187:drug effects*; D006657:Histones / Q000378:metabolism; D006801:Humans; D008322:Mammals / Q000235:genetics*; D053758:Nanoparticles / Q000633:toxicity*; D011499:Protein Processing, Post-Translational / Q000187:drug effects
chemical_list: D006657:Histones
keywords: DNA methylation; epigenetics; histone modification; ncRNAs; noncoding RNAs