title: A Physical Heart Failure Simulation System Utilizing the Total Artificial Heart and Modified Donovan Mock Circulation.
abstract: With the growth and diversity of mechanical circulatory support (MCS) systems entering clinical use, a need exists for a robust mock circulation system capable of reliably emulating and reproducing physiologic as well as pathophysiologic states for use in MCS training and inter-device comparison. We report on the development of such a platform utilizing the SynCardia Total Artificial Heart and a modified Donovan Mock Circulation System, capable of being driven at normal and reduced output. With this platform, clinically relevant heart failure hemodynamics could be reliably reproduced as evidenced by elevated left atrial pressure (+112%), reduced aortic flow (-12.6%), blunted Starling-like behavior, and increased afterload sensitivity when compared with normal function. Similarly, pressure-volume relationships demonstrated enhanced sensitivity to afterload and decreased Starling-like behavior in the heart failure model. Lastly, the platform was configured to allow the easy addition of a left ventricular assist device (HeartMate II at 9600 RPM), which upon insertion resulted in improvement of hemodynamics. The present configuration has the potential to serve as a viable system for training and research, aimed at fostering safe and effective MCS device use.
authors.affiliation: Biomedical Engineering GIDP, University of Arizona, Tucson, AZ.
authors.forename: Jessica R
authors.initials: JR
authors.lastname: Crosby
authors.affiliation: Biomedical Engineering GIDP, University of Arizona, Tucson, AZ.
authors.forename: Katrina J
authors.initials: KJ
authors.lastname: DeCook
authors.affiliation: Biomedical Engineering GIDP, University of Arizona, Tucson, AZ.|Department of Medicine, Sarver Heart Center, University of Arizona, Tucson, AZ.|Artificial Heart Department, Banner University Medical Center, University of Arizona, Tucson, AZ.
authors.forename: Phat L
authors.initials: PL
authors.lastname: Tran
authors.affiliation: Artificial Heart Department, Banner University Medical Center, University of Arizona, Tucson, AZ.
authors.forename: Edward
authors.initials: E
authors.lastname: Betterton
authors.affiliation: Biomedical Engineering GIDP, University of Arizona, Tucson, AZ.|Department of Medicine, Sarver Heart Center, University of Arizona, Tucson, AZ.|Artificial Heart Department, Banner University Medical Center, University of Arizona, Tucson, AZ.
authors.forename: Richard G
authors.initials: RG
authors.lastname: Smith
authors.affiliation: Department of Surgery, University of Arizona, Tucson, AZ.
authors.forename: Douglas F
authors.initials: DF
authors.lastname: Larson
authors.affiliation: Department of Surgery, University of Arizona, Tucson, AZ.
authors.forename: Zain I
authors.initials: ZI
authors.lastname: Khalpey
authors.affiliation: Columbia University, New York, NY, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Burkhoff
authors.affiliation: Biomedical Engineering GIDP, University of Arizona, Tucson, AZ.|Department of Biomedical Engineering, University of Arizona, Tucson, AZ.|Department of Medicine, Sarver Heart Center, University of Arizona, Tucson, AZ.
authors.forename: Marvin J
authors.initials: MJ
authors.lastname: Slepian
mesh_terms: D062185:Atrial Pressure; D003198:Computer Simulation; D004867:Equipment Design; D006321:Heart / Q000503:physiopathology*; D006333:Heart Failure / Q000503:physiopathology*; D006354:Heart, Artificial; D006353:Heart-Assist Devices; D006439:Hemodynamics; D006801:Humans; D008955:Models, Cardiovascular; D016277:Ventricular Function, Left
keywords: -Donovan mock circulation; -Heart failure; -Mechanical circulatory support; -Physiologic simulation; -Ventricular assist device; Total artificial heart