title: Melatonin and Nitrones As Potential Therapeutic Agents for Stroke.
abstract: Stroke is a disease of aging affecting millions of people worldwide, and recombinant tissue-type plasminogen activator (r-tPA) is the only treatment approved. However, r-tPA has a low therapeutic window and secondary effects which limit its beneficial outcome, urging thus the search for new more efficient therapies. Among them, neuroprotection based on melatonin or nitrones, as free radical traps, have arisen as drug candidates due to their strong antioxidant power. In thisPerspectivearticle, an update on the specific results of the melatonin and several new nitrones are presented.
authors.affiliation: Department of Toxicology and Pharmacology, Faculty of Veterinary Medicine, Complutense University of Madrid Madrid, Spain.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Romero
authors.affiliation: Department of Toxicology and Pharmacology, Faculty of Veterinary Medicine, Complutense University of Madrid Madrid, Spain.
authors.forename: Eva
authors.initials: E
authors.lastname: Ramos
authors.affiliation: Paediatric Unit, La Paz University Hospital Madrid, Spain.
authors.forename: Paloma
authors.initials: P
authors.lastname: Patiño
authors.affiliation: Department of Biochemistry and Molecular Biology II, Faculty of Pharmacy, Complutense University of Madrid, Ciudad Universitaria Madrid, Spain.
authors.forename: Maria J
authors.initials: MJ
authors.lastname: Oset-Gasque
authors.affiliation: Faculty of Health, Camilo José Cela UniversityMadrid, Spain; Neuropsychopharmacology Unit, "Hospital 12 de Octubre" Research InstituteMadrid, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: López-Muñoz
authors.affiliation: Laboratory of Medicinal Chemistry, Institute of General Organic Chemistry (CSIC) Madrid, Spain.
authors.forename: José
authors.initials: J
authors.lastname: Marco-Contelles
authors.affiliation: Neurovascular Research Group, Instituto de Biomedicina de Sevilla, Hospital Virgen del Rocío, Sevilla, Spain
authors.forename: María I
authors.initials: MR
authors.lastname: Ayuso
authors.affiliation: Department of Investigation, IRYCIS, Hospital Ramón y Cajal, Madrid, Spain
authors.forename: Alberto
authors.initials: A
authors.lastname: Alcázar
keywords: melatonin; neuroprotection; nitrones; oxidative stress; stroke