title: The loading of condensin in the context of chromatin.
abstract: The packaging of DNA into chromosomes is a ubiquitous process that enables living organisms to structure and transmit their genome accurately through cell divisions. In the three kingdoms of life, the architecture and dynamics of chromosomes rely upon ring-shaped SMC (Structural Maintenance of Chromosomes) condensin complexes. To understand how condensin rings organize chromosomes, it is essential to decipher how they associate with chromatin filaments. Here, we use recent evidence to discuss the role played by nucleosomes and transcription factors in the loading of condensin at transcribed genes. We propose a model whereby cis-acting features nestled in the promoters of active genes synergistically attract condensin rings and promote their association with DNA.
authors.affiliation: LBMC-Laboratory of Biology and Modelling of the Cell, CNRS, ENS-Lyon, INSERM, UCBL, Ecole Normale Supérieure de Lyon, 46 Allée d'Italie, 69364, Lyon, France.
authors.forename: Xavier
authors.initials: X
authors.lastname: Robellet
authors.affiliation: LBMC-Laboratory of Biology and Modelling of the Cell, CNRS, ENS-Lyon, INSERM, UCBL, Ecole Normale Supérieure de Lyon, 46 Allée d'Italie, 69364, Lyon, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Vanoosthuyse
authors.affiliation: LBMC-Laboratory of Biology and Modelling of the Cell, CNRS, ENS-Lyon, INSERM, UCBL, Ecole Normale Supérieure de Lyon, 46 Allée d'Italie, 69364, Lyon, France. pascal.bernard@ens-lyon.fr.
authors.forename: Pascal
authors.identifier: http://orcid.org/0000-0003-2732-9685
authors.initials: P
authors.lastname: Bernard
mesh_terms: D000251:Adenosine Triphosphatases / Q000737:chemistry / Q000235:genetics*; D018797:Cell Cycle Proteins / Q000235:genetics; D002455:Cell Division / Q000235:genetics; D002843:Chromatin / Q000737:chemistry / Q000235:genetics* / Q000648:ultrastructure; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics; D002875:Chromosomes / Q000737:chemistry / Q000235:genetics* / Q000648:ultrastructure; D004247:DNA / Q000235:genetics* / Q000648:ultrastructure; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000235:genetics*; D016678:Genome / Q000235:genetics; D008938:Mitosis / Q000235:genetics; D046912:Multiprotein Complexes / Q000737:chemistry / Q000235:genetics*; D009707:Nucleosomes / Q000235:genetics; D011401:Promoter Regions, Genetic; D000098550:Structural Maintenance of Chromosome Protein 1
chemical_list: D018797:Cell Cycle Proteins; D002843:Chromatin; D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins; D046912:Multiprotein Complexes; D009707:Nucleosomes; C108312:condensin complexes; D000098550:Structural Maintenance of Chromosome Protein 1; D004247:DNA; D000251:Adenosine Triphosphatases
keywords: Chromosome dynamics; Condensin; Nucleosome; SMC proteins