title: Differences in survival outcome between oropharyngeal and oral cavity squamous cell carcinoma in relation to HPV status.
abstract: BACKGROUND
  This study examined the prognostic significance of human papillomavirus (HPV) in patients with oropharyngeal and oral cavity squamous cell carcinoma (SCC).
  
  
  METHODS
  Tissue microarrays were constructed from oropharyngeal and oral cavity SCC (n = 143). The presence of functional HPV in tumour was determined by combined assessments of p16 immunohistochemistry and HPV in situ hybridisation.
  
  
  RESULTS
  Oropharyngeal SCC patients presented with more advanced disease in comparison with oral cavity SCC patients (P = 0.001). HPV is present in 60% and 61% of oropharyngeal and oral cavity SCC patients, respectively. HPV-positive oropharyngeal SCC patients with advanced TNM stages displayed better overall and disease-free survival outcomes than HPV-negative patients (P = 0.022 and 0.046, respectively). Such survival differences were not observed in oral cavity SCC.
  
  
  CONCLUSIONS
  HPV is common in both oropharyngeal and oral cavity SCC and is associated with better survival outcome in oropharyngeal SCC but not in oral cavity SCC patients.
authors.affiliation: Cancer Pathology, Bosch Institute, The University of Sydney, Sydney, Australia.|Discipline of Pathology, School of Medicine, Western Sydney University, Sydney, Australia.|Centre for Oncology Education and Research Translation (CONCERT), Ingham Institute for Applied Medical Research, Sydney, Australia.|Department of Anatomical Pathology, Sydney South West Pathology Service (SSWPS) Liverpool Hospital, Sydney, Australia.
authors.forename: Kenneth
authors.initials: K
authors.lastname: Lai
authors.affiliation: Discipline of Pathology, School of Medicine, Western Sydney University, Sydney, Australia.|Centre for Oncology Education and Research Translation (CONCERT), Ingham Institute for Applied Medical Research, Sydney, Australia.|Department of Anatomical Pathology, Sydney South West Pathology Service (SSWPS) Liverpool Hospital, Sydney, Australia.|Faculty of Medicine, South Western Sydney Clinical School, University of New South Wales, Sydney, Australia.
authors.forename: Murray
authors.initials: M
authors.lastname: Killingsworth
authors.affiliation: Sydney Medical School (Pharmacology), The University of Sydney, Sydney, Australia.|Bosch Institute, The University of Sydney, Sydney, Australia.
authors.forename: Slade
authors.initials: S
authors.lastname: Matthews
authors.affiliation: Discipline of Pathology, School of Medicine, Western Sydney University, Sydney, Australia.|Centre for Oncology Education and Research Translation (CONCERT), Ingham Institute for Applied Medical Research, Sydney, Australia.
authors.forename: Nicole
authors.initials: N
authors.lastname: Caixeiro
authors.affiliation: Department of Anatomical Pathology, Sydney South West Pathology Service (SSWPS) Liverpool Hospital, Sydney, Australia.
authors.forename: Carlyn
authors.initials: C
authors.lastname: Evangelista
authors.affiliation: Department of Anatomical Pathology, Sydney South West Pathology Service (SSWPS) Liverpool Hospital, Sydney, Australia.
authors.forename: Xiao
authors.initials: X
authors.lastname: Wu
authors.affiliation: Faculty of Medicine, South Western Sydney Clinical School, University of New South Wales, Sydney, Australia.|Department of Head & Neck Surgery, Liverpool Hospital, Sydney, Australia.
authors.forename: James
authors.initials: J
authors.lastname: Wykes
authors.affiliation: Department of Head & Neck Surgery, Liverpool Hospital, Sydney, Australia.
authors.forename: Alan
authors.initials: A
authors.lastname: Samakeh
authors.affiliation: Faculty of Medicine, South Western Sydney Clinical School, University of New South Wales, Sydney, Australia.|Department of Radiation Oncology, Liverpool Hospital, Sydney, Australia.
authors.forename: Dion
authors.initials: D
authors.lastname: Forstner
authors.affiliation: Department of Head & Neck Surgery, Liverpool Hospital, Sydney, Australia.
authors.forename: Navin
authors.initials: N
authors.lastname: Niles
authors.affiliation: Central Clinical School, University of Sydney, Sydney, Australia.
authors.forename: Angela
authors.initials: A
authors.lastname: Hong
authors.affiliation: Cancer Pathology, Bosch Institute, The University of Sydney, Sydney, Australia.|Discipline of Pathology, School of Medicine, Western Sydney University, Sydney, Australia.|Centre for Oncology Education and Research Translation (CONCERT), Ingham Institute for Applied Medical Research, Sydney, Australia.|Department of Anatomical Pathology, Sydney South West Pathology Service (SSWPS) Liverpool Hospital, Sydney, Australia.|Faculty of Medicine, South Western Sydney Clinical School, University of New South Wales, Sydney, Australia.
authors.forename: Cheok Soon
authors.initials: CS
authors.lastname: Lee
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000401:mortality* / Q000821:virology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000150:complications / Q000401:mortality* / Q000821:virology; D009959:Oropharyngeal Neoplasms / Q000150:complications / Q000401:mortality* / Q000821:virology; D030361:Papillomavirus Infections / Q000150:complications / Q000401:mortality*; D012307:Risk Factors; D016019:Survival Analysis; D046888:Tissue Array Analysis
keywords: human papilloma virus; oral cavity; oropharyngeal; squamous cell carcinoma; survival outcome