title: Tumor-targeted supramolecular nanoparticles self-assembled from a ruthenium-β-cyclodextrin complex and an adamantane-functionalized peptide.
abstract: We report here a supramolecular strategy to assemble a cyclodextrin-functionalized anticancer Ru(ii) complex with an adamantane-appended tumor-targeting peptide into discrete and stable phosphorescent nanostructures that can induce cell death in integrin αvβ3-rich tumor cells with high selectivity. This strategy presents new opportunities for the construction of tumor-targeting metallo-anticancer therapeutics.
authors.affiliation: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. China. cesmzw@mail.sysu.edu.cn tancaip@mail.sysu.edu.cn.
authors.forename: Shan-Shan
authors.initials: SS
authors.lastname: Xue
authors.affiliation: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. China. cesmzw@mail.sysu.edu.cn tancaip@mail.sysu.edu.cn.
authors.forename: Cai-Ping
authors.initials: CP
authors.lastname: Tan
authors.affiliation: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. China. cesmzw@mail.sysu.edu.cn tancaip@mail.sysu.edu.cn.
authors.forename: Mu-He
authors.initials: MH
authors.lastname: Chen
authors.affiliation: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. China. cesmzw@mail.sysu.edu.cn tancaip@mail.sysu.edu.cn.
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Cao
authors.affiliation: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. China. cesmzw@mail.sysu.edu.cn tancaip@mail.sysu.edu.cn.
authors.forename: Dong-Yang
authors.initials: DY
authors.lastname: Zhang
authors.affiliation: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. China. cesmzw@mail.sysu.edu.cn tancaip@mail.sysu.edu.cn.
authors.forename: Rui-Rong
authors.initials: RR
authors.lastname: Ye
authors.affiliation: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. China. cesmzw@mail.sysu.edu.cn tancaip@mail.sysu.edu.cn.
authors.forename: Liang-Nian
authors.initials: LN
authors.lastname: Ji
authors.affiliation: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. China. cesmzw@mail.sysu.edu.cn tancaip@mail.sysu.edu.cn.
authors.forename: Zong-Wan
authors.initials: ZW
authors.lastname: Mao