title: Group-Wide, Prospective Study of Ototoxicity Assessment in Children Receiving Cisplatin Chemotherapy (ACCL05C1): A Report From the Children's Oncology Group.
abstract: Purpose Optimal assessment methods and criteria for reporting hearing outcomes in children who receive treatment with cisplatin are uncertain. The objectives of our study were to compare different ototoxicity classification systems, to evaluate the feasibility of including otoacoustic emissions and extended high frequency audiometry, and to evaluate a central review mechanism for audiologic results for cisplatin-treated children in the cooperative group setting. Patients and Methods Eligible participants were 1 to 30 years, with planned cisplatin-containing treatment. Hearing evaluations were conducted at baseline, before each cisplatin cycle, and at the end of therapy. Audiologic results were assessed and graded by the testing audiologist and by two central review audiologists using the American Speech-Language-Hearing Association Ototoxicity Criteria (ASHA), Common Terminology Criteria for Adverse Events, version 3.0 (CTCAE), and Brock Ototoxicity Grades (Brock). One central reviewer also used the International Society of Pediatric Oncology Ototoxicity Scale (SIOP). Results At the end of treatment, the prevalence of any degree of ototoxicity ranged from 40% to 56%, and severe ototoxicity ranged from 7% to 22%. Compared with CTCAE, SIOP detected significantly more ototoxicity ( P = .004), whereas Brock criteria detected significantly fewer patients with any or severe ototoxicity ( P < .001 for both). SIOP detected ototoxicity earlier than did the other scales. Agreement between the central reviewers and the institutional audiologist was almost perfect for ASHA and Brock, whereas the poorest agreement occurred with CTCAE. Conclusion The SIOP scale may be superior to ASHA, Brock, and CTCAE scales for classifying ototoxicity in pediatric patients who were treated with cisplatin. Future studies should evaluate inter-rater reliability of the SIOP scale.
authors.affiliation: Kristin R. Knight and Edward A. Neuwelt, Oregon Health and Science University, Portland, OR; Lu Chen and Ha Dang, Children's Oncology Group, Monrovia; David Freyer, Children's Hospital Los Angeles; Ha Dang, University of Southern California, Los Angeles; Lanie Lindenfeld, City of Hope, Duarte; Brad H. Pollock, University of California, Davis, Davis, CA; Richard Aplenc, Children's Hospital of Philadelphia, Philadelphia, PA; Mary Bancroft, University of Florida, Gainesville; Dale F. Kraemer, University of Florida, Jacksonville, FL; Bonnie Bliss, Biljana Gillmeister, Jane Meza, and Lillian Sung, The Hospital for Sick Children, Toronto; and Eleanor Hendershot, McMaster Children's Hospital, Hamilton, Ontario, Canada.
authors.forename: Kristin R
authors.initials: KR
authors.lastname: Knight
authors.affiliation: Kristin R. Knight and Edward A. Neuwelt, Oregon Health and Science University, Portland, OR; Lu Chen and Ha Dang, Children's Oncology Group, Monrovia; David Freyer, Children's Hospital Los Angeles; Ha Dang, University of Southern California, Los Angeles; Lanie Lindenfeld, City of Hope, Duarte; Brad H. Pollock, University of California, Davis, Davis, CA; Richard Aplenc, Children's Hospital of Philadelphia, Philadelphia, PA; Mary Bancroft, University of Florida, Gainesville; Dale F. Kraemer, University of Florida, Jacksonville, FL; Bonnie Bliss, Biljana Gillmeister, Jane Meza, and Lillian Sung, The Hospital for Sick Children, Toronto; and Eleanor Hendershot, McMaster Children's Hospital, Hamilton, Ontario, Canada.
authors.forename: Lu
authors.initials: L
authors.lastname: Chen
authors.affiliation: Kristin R. Knight and Edward A. Neuwelt, Oregon Health and Science University, Portland, OR; Lu Chen and Ha Dang, Children's Oncology Group, Monrovia; David Freyer, Children's Hospital Los Angeles; Ha Dang, University of Southern California, Los Angeles; Lanie Lindenfeld, City of Hope, Duarte; Brad H. Pollock, University of California, Davis, Davis, CA; Richard Aplenc, Children's Hospital of Philadelphia, Philadelphia, PA; Mary Bancroft, University of Florida, Gainesville; Dale F. Kraemer, University of Florida, Jacksonville, FL; Bonnie Bliss, Biljana Gillmeister, Jane Meza, and Lillian Sung, The Hospital for Sick Children, Toronto; and Eleanor Hendershot, McMaster Children's Hospital, Hamilton, Ontario, Canada.
authors.forename: David
authors.initials: D
authors.lastname: Freyer
authors.affiliation: Kristin R. Knight and Edward A. Neuwelt, Oregon Health and Science University, Portland, OR; Lu Chen and Ha Dang, Children's Oncology Group, Monrovia; David Freyer, Children's Hospital Los Angeles; Ha Dang, University of Southern California, Los Angeles; Lanie Lindenfeld, City of Hope, Duarte; Brad H. Pollock, University of California, Davis, Davis, CA; Richard Aplenc, Children's Hospital of Philadelphia, Philadelphia, PA; Mary Bancroft, University of Florida, Gainesville; Dale F. Kraemer, University of Florida, Jacksonville, FL; Bonnie Bliss, Biljana Gillmeister, Jane Meza, and Lillian Sung, The Hospital for Sick Children, Toronto; and Eleanor Hendershot, McMaster Children's Hospital, Hamilton, Ontario, Canada.
authors.forename: Richard
authors.initials: R
authors.lastname: Aplenc
authors.affiliation: Kristin R. Knight and Edward A. Neuwelt, Oregon Health and Science University, Portland, OR; Lu Chen and Ha Dang, Children's Oncology Group, Monrovia; David Freyer, Children's Hospital Los Angeles; Ha Dang, University of Southern California, Los Angeles; Lanie Lindenfeld, City of Hope, Duarte; Brad H. Pollock, University of California, Davis, Davis, CA; Richard Aplenc, Children's Hospital of Philadelphia, Philadelphia, PA; Mary Bancroft, University of Florida, Gainesville; Dale F. Kraemer, University of Florida, Jacksonville, FL; Bonnie Bliss, Biljana Gillmeister, Jane Meza, and Lillian Sung, The Hospital for Sick Children, Toronto; and Eleanor Hendershot, McMaster Children's Hospital, Hamilton, Ontario, Canada.
authors.forename: Mary
authors.initials: M
authors.lastname: Bancroft
authors.affiliation: Kristin R. Knight and Edward A. Neuwelt, Oregon Health and Science University, Portland, OR; Lu Chen and Ha Dang, Children's Oncology Group, Monrovia; David Freyer, Children's Hospital Los Angeles; Ha Dang, University of Southern California, Los Angeles; Lanie Lindenfeld, City of Hope, Duarte; Brad H. Pollock, University of California, Davis, Davis, CA; Richard Aplenc, Children's Hospital of Philadelphia, Philadelphia, PA; Mary Bancroft, University of Florida, Gainesville; Dale F. Kraemer, University of Florida, Jacksonville, FL; Bonnie Bliss, Biljana Gillmeister, Jane Meza, and Lillian Sung, The Hospital for Sick Children, Toronto; and Eleanor Hendershot, McMaster Children's Hospital, Hamilton, Ontario, Canada.
authors.forename: Bonnie
authors.initials: B
authors.lastname: Bliss
authors.affiliation: Kristin R. Knight and Edward A. Neuwelt, Oregon Health and Science University, Portland, OR; Lu Chen and Ha Dang, Children's Oncology Group, Monrovia; David Freyer, Children's Hospital Los Angeles; Ha Dang, University of Southern California, Los Angeles; Lanie Lindenfeld, City of Hope, Duarte; Brad H. Pollock, University of California, Davis, Davis, CA; Richard Aplenc, Children's Hospital of Philadelphia, Philadelphia, PA; Mary Bancroft, University of Florida, Gainesville; Dale F. Kraemer, University of Florida, Jacksonville, FL; Bonnie Bliss, Biljana Gillmeister, Jane Meza, and Lillian Sung, The Hospital for Sick Children, Toronto; and Eleanor Hendershot, McMaster Children's Hospital, Hamilton, Ontario, Canada.
authors.forename: Ha
authors.initials: H
authors.lastname: Dang
authors.affiliation: Kristin R. Knight and Edward A. Neuwelt, Oregon Health and Science University, Portland, OR; Lu Chen and Ha Dang, Children's Oncology Group, Monrovia; David Freyer, Children's Hospital Los Angeles; Ha Dang, University of Southern California, Los Angeles; Lanie Lindenfeld, City of Hope, Duarte; Brad H. Pollock, University of California, Davis, Davis, CA; Richard Aplenc, Children's Hospital of Philadelphia, Philadelphia, PA; Mary Bancroft, University of Florida, Gainesville; Dale F. Kraemer, University of Florida, Jacksonville, FL; Bonnie Bliss, Biljana Gillmeister, Jane Meza, and Lillian Sung, The Hospital for Sick Children, Toronto; and Eleanor Hendershot, McMaster Children's Hospital, Hamilton, Ontario, Canada.
authors.forename: Biljana
authors.initials: B
authors.lastname: Gillmeister
authors.affiliation: Kristin R. Knight and Edward A. Neuwelt, Oregon Health and Science University, Portland, OR; Lu Chen and Ha Dang, Children's Oncology Group, Monrovia; David Freyer, Children's Hospital Los Angeles; Ha Dang, University of Southern California, Los Angeles; Lanie Lindenfeld, City of Hope, Duarte; Brad H. Pollock, University of California, Davis, Davis, CA; Richard Aplenc, Children's Hospital of Philadelphia, Philadelphia, PA; Mary Bancroft, University of Florida, Gainesville; Dale F. Kraemer, University of Florida, Jacksonville, FL; Bonnie Bliss, Biljana Gillmeister, Jane Meza, and Lillian Sung, The Hospital for Sick Children, Toronto; and Eleanor Hendershot, McMaster Children's Hospital, Hamilton, Ontario, Canada.
authors.forename: Eleanor
authors.initials: E
authors.lastname: Hendershot
authors.affiliation: Kristin R. Knight and Edward A. Neuwelt, Oregon Health and Science University, Portland, OR; Lu Chen and Ha Dang, Children's Oncology Group, Monrovia; David Freyer, Children's Hospital Los Angeles; Ha Dang, University of Southern California, Los Angeles; Lanie Lindenfeld, City of Hope, Duarte; Brad H. Pollock, University of California, Davis, Davis, CA; Richard Aplenc, Children's Hospital of Philadelphia, Philadelphia, PA; Mary Bancroft, University of Florida, Gainesville; Dale F. Kraemer, University of Florida, Jacksonville, FL; Bonnie Bliss, Biljana Gillmeister, Jane Meza, and Lillian Sung, The Hospital for Sick Children, Toronto; and Eleanor Hendershot, McMaster Children's Hospital, Hamilton, Ontario, Canada.
authors.forename: Dale F
authors.initials: DF
authors.lastname: Kraemer
authors.affiliation: Kristin R. Knight and Edward A. Neuwelt, Oregon Health and Science University, Portland, OR; Lu Chen and Ha Dang, Children's Oncology Group, Monrovia; David Freyer, Children's Hospital Los Angeles; Ha Dang, University of Southern California, Los Angeles; Lanie Lindenfeld, City of Hope, Duarte; Brad H. Pollock, University of California, Davis, Davis, CA; Richard Aplenc, Children's Hospital of Philadelphia, Philadelphia, PA; Mary Bancroft, University of Florida, Gainesville; Dale F. Kraemer, University of Florida, Jacksonville, FL; Bonnie Bliss, Biljana Gillmeister, Jane Meza, and Lillian Sung, The Hospital for Sick Children, Toronto; and Eleanor Hendershot, McMaster Children's Hospital, Hamilton, Ontario, Canada.
authors.forename: Lanie
authors.initials: L
authors.lastname: Lindenfeld
authors.affiliation: Kristin R. Knight and Edward A. Neuwelt, Oregon Health and Science University, Portland, OR; Lu Chen and Ha Dang, Children's Oncology Group, Monrovia; David Freyer, Children's Hospital Los Angeles; Ha Dang, University of Southern California, Los Angeles; Lanie Lindenfeld, City of Hope, Duarte; Brad H. Pollock, University of California, Davis, Davis, CA; Richard Aplenc, Children's Hospital of Philadelphia, Philadelphia, PA; Mary Bancroft, University of Florida, Gainesville; Dale F. Kraemer, University of Florida, Jacksonville, FL; Bonnie Bliss, Biljana Gillmeister, Jane Meza, and Lillian Sung, The Hospital for Sick Children, Toronto; and Eleanor Hendershot, McMaster Children's Hospital, Hamilton, Ontario, Canada.
authors.forename: Jane
authors.initials: J
authors.lastname: Meza
authors.affiliation: Kristin R. Knight and Edward A. Neuwelt, Oregon Health and Science University, Portland, OR; Lu Chen and Ha Dang, Children's Oncology Group, Monrovia; David Freyer, Children's Hospital Los Angeles; Ha Dang, University of Southern California, Los Angeles; Lanie Lindenfeld, City of Hope, Duarte; Brad H. Pollock, University of California, Davis, Davis, CA; Richard Aplenc, Children's Hospital of Philadelphia, Philadelphia, PA; Mary Bancroft, University of Florida, Gainesville; Dale F. Kraemer, University of Florida, Jacksonville, FL; Bonnie Bliss, Biljana Gillmeister, Jane Meza, and Lillian Sung, The Hospital for Sick Children, Toronto; and Eleanor Hendershot, McMaster Children's Hospital, Hamilton, Ontario, Canada.
authors.forename: Edward A
authors.initials: EA
authors.lastname: Neuwelt
authors.affiliation: Kristin R. Knight and Edward A. Neuwelt, Oregon Health and Science University, Portland, OR; Lu Chen and Ha Dang, Children's Oncology Group, Monrovia; David Freyer, Children's Hospital Los Angeles; Ha Dang, University of Southern California, Los Angeles; Lanie Lindenfeld, City of Hope, Duarte; Brad H. Pollock, University of California, Davis, Davis, CA; Richard Aplenc, Children's Hospital of Philadelphia, Philadelphia, PA; Mary Bancroft, University of Florida, Gainesville; Dale F. Kraemer, University of Florida, Jacksonville, FL; Bonnie Bliss, Biljana Gillmeister, Jane Meza, and Lillian Sung, The Hospital for Sick Children, Toronto; and Eleanor Hendershot, McMaster Children's Hospital, Hamilton, Ontario, Canada.
authors.forename: Brad H
authors.initials: BH
authors.lastname: Pollock
authors.affiliation: Kristin R. Knight and Edward A. Neuwelt, Oregon Health and Science University, Portland, OR; Lu Chen and Ha Dang, Children's Oncology Group, Monrovia; David Freyer, Children's Hospital Los Angeles; Ha Dang, University of Southern California, Los Angeles; Lanie Lindenfeld, City of Hope, Duarte; Brad H. Pollock, University of California, Davis, Davis, CA; Richard Aplenc, Children's Hospital of Philadelphia, Philadelphia, PA; Mary Bancroft, University of Florida, Gainesville; Dale F. Kraemer, University of Florida, Jacksonville, FL; Bonnie Bliss, Biljana Gillmeister, Jane Meza, and Lillian Sung, The Hospital for Sick Children, Toronto; and Eleanor Hendershot, McMaster Children's Hospital, Hamilton, Ontario, Canada.
authors.forename: Lillian
authors.initials: L
authors.lastname: Sung
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D001298:Audiology; D002648:Child; D002675:Child, Preschool; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects*; D015331:Cohort Studies; D005260:Female; D034381:Hearing Loss / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D007223:Infant; D008297:Male; D017084:Otoacoustic Emissions, Spontaneous / Q000187:drug effects; D016032:Randomized Controlled Trials as Topic; D055815:Young Adult
chemical_list: D002945:Cisplatin