title: Multicellular Spheroids as a Model for Hypoxia-induced EMT.
abstract: Oral cancer is aggressive and invasive. The 5-year survival rate is around 50% and has not improved in over 50 years. One-third of oral cancer patients develop local and/or regional tumor recurrence following treatment. We continue to use our multicellular spheroid (MCS) model to better understand how the extracellular matrix contributes to epithelial to mesenchymal transition and how hypoxia contributes to the progression of oral squamous cell carcinoma (SCC).
authors.affiliation: Department of Orofacial Sciences, University of California at San Francisco, San Francisco, CA, U.S.A.
authors.forename: Casey
authors.initials: C
authors.lastname: Lee
authors.affiliation: Department of Orofacial Sciences, University of California at San Francisco, San Francisco, CA, U.S.A.
authors.forename: Amanda
authors.initials: A
authors.lastname: Siu
authors.affiliation: Department of Orofacial Sciences, University of California at San Francisco, San Francisco, CA, U.S.A. Daniel.ramos@ucsf.edu.
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Ramos
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology; D015687:Cell Hypoxia; D045744:Cell Line, Tumor; D058750:Epithelial-Mesenchymal Transition; D005353:Fibronectins / Q000378:metabolism; D006801:Humans; D007633:Keratins / Q000378:metabolism; D008962:Models, Theoretical; D018874:Spheroids, Cellular; D014062:Tongue Neoplasms / Q000378:metabolism / Q000473:pathology; D014746:Vimentin / Q000378:metabolism
chemical_list: D005353:Fibronectins; D014746:Vimentin; D007633:Keratins
keywords: EMT; Hypoxia; Spheroid; multicellular spheroid formation