title: Adiponectin Gene Polymorphism and Ischemic Stroke Subtypes in a Chinese Population.
abstract: As an adipose tissue-specific protein, adiponectin has been suggested as a protective factor for stroke, acting through anti-inflammatory and antiatherogenic effects. Therefore, we aimed to investigate whether 3 polymorphisms (rs1501299, rs2241767, and rs3774261) in the adiponectin (ADIPOQ) gene and their haplotypes were associated with ischemic stroke (IS) and its subtypes in a Chinese population. ADIPOQ gene rs1501299, rs2241767, and rs3774261 polymorphisms were analyzed in 385 IS patients, including 182 patients with large-artery atherosclerosis (LAA), 203 patients with small-vessel occlusion (SVO), and 418 matched controls. The subjects were genotyped by using polymerase chain reaction-restriction fragment length polymorphism analysis. In univariate logistic analysis, the A allele frequency of rs2241767 was moderately higher in IS and LAA patients than that in controls (P = .028 and P = .017, respectively). Compared with the wide-type AA homozygote, both the genotype GG and the dominant model (GG+AG) of rs2241767 moderately increased the risk of LAA (P = .040 and P = .034, respectively). In multivariate logistic regression analysis, the genotype GG of rs2241767 was independently related to IS and LAA patients (adjusted, odds ratio [OR] = 1.822, 95% confidence interval [CI]: 1.037-3.202, P = .037 and OR = 2.051, 95% CI: 1.041-4.041, P = .038, respectively) rather than SVO. In contrast, no relationship was observed between the polymorphism of rs1501299 and rs3774261 and either subtype of IS using both univariate and multivariate logistic regression analyses. In addition, the Trs1501299-Grs2241767-Ars3774261haplotype showed a moderately increased risk of IS and LAA (OR = 1.595, 95% CI: 1.058-2.406, P = .025 and OR = 1.709, 95% CI: 1.047-2.789, P = .031, respectively) but not of SVO. In conclusion, this study tentatively demonstrated that the polymorphism of rs2241767 and the Trs1501299-Grs2241767-Ars3774261haplotype were associated with susceptibility to IS and LAA in a Chinese population.
authors.affiliation: Department of Emergency, Huludao Center Hospital, Huludao, Liaoning, China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Emergency, Huludao Center Hospital, Huludao, Liaoning, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Lu
authors.affiliation: Division of Radiation Imaging, Huludao Center Hospital, Huludao, Liaoning, China.
authors.forename: Zhongnan
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Emergency, Huludao Center Hospital, Huludao, Liaoning, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Jiao
authors.affiliation: Department of Cardiology, Huludao Center Hospital, Huludao, Liaoning, China.
authors.forename: Hanping
authors.initials: H
authors.lastname: Wang
authors.affiliation: Intensive Care Unit, Huludao Center Hospital, Huludao, Liaoning, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Yang
authors.affiliation: Division of Radiation Imaging, Huludao Center Hospital, Huludao, Liaoning, China. Electronic address: xclss2005@163.com.
authors.forename: Tao
authors.initials: T
authors.lastname: Yu
mesh_terms: D052242:Adiponectin / Q000235:genetics*; D000368:Aged; D044466:Asian People / Q000235:genetics; D002545:Brain Ischemia / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002681:China / Q000453:epidemiology; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D002537:Intracranial Arteriosclerosis / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D020521:Stroke / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics*
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin
keywords: ADIPOQ gene; Adiponectin; ischemic stroke; polymorphism; subtypes