title: Calcium-41: a technology for monitoring changes in bone mineral.
abstract: The rare, long-lived radiotracer,41Ca, measured by accelerator mass spectrometry in the urine or serum following incorporation into the bone provides an ultra-sensitive tool to assess changes in bone calcium balance in response to an intervention. Changes in bone balance can be followed for years with one small dose that is both radiologically and biologically non-invasive. Sequential interventions can be compared, with greater precision than they can with biochemical markers of bone turnover and with greater power than with bone densitometry. This method is especially useful to screen interventions over a period of weeks. The development and validation of this tool and its applications are reviewed. Mini abstract: Use of41Ca measured in the urine or blood by accelerator mass spectrometry to assess bone balance provides a tool to compare the relative efficacy of multiple interventions. This perspective provides insights in the use of this novel method and comparisons with more traditional methods for evaluating the efficacy of interventions.
authors.affiliation: Department of Nutrition Science, Purdue University, 700 W State Street, West Lafayette, IN, 47907, USA. weavercm@purdue.edu.
authors.forename: C M
authors.initials: CM
authors.lastname: Weaver
authors.affiliation: Department of Nutrition Science, Purdue University, 700 W State Street, West Lafayette, IN, 47907, USA.
authors.forename: B R
authors.initials: BR
authors.lastname: Martin
authors.affiliation: Department of Physics, Purdue University, 525 Northwestern Ave., West Lafayette, IN, 47907-2036, USA.
authors.forename: G S
authors.initials: GS
authors.lastname: Jackson
authors.affiliation: Department of Statistics, Purdue University, 250 N University Street, West Lafayette, IN, 47907, USA.
authors.forename: G P
authors.initials: GP
authors.lastname: McCabe
authors.affiliation: Indiana University School of Medicine, Indianapolis, IN, 46223, USA.
authors.forename: M
authors.initials: M
authors.lastname: Peacock
authors.affiliation: Department of Nutrition Science, Purdue University, 700 W State Street, West Lafayette, IN, 47907, USA.
authors.forename: M
authors.initials: M
authors.lastname: Wastney
mesh_terms: D000818:Animals; D016723:Bone Remodeling / Q000502:physiology*; D001842:Bone and Bones / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D002132:Calcium Radioisotopes / Q000008:administration & dosage / Q000652:urine; D006801:Humans; D023421:Models, Animal
chemical_list: D002132:Calcium Radioisotopes; C000615347:Calcium-41; D002118:Calcium
keywords: 41Ca; Calcium balance; Calcium bone turnover