title: miR-451 inhibits cell growth, migration and angiogenesis in human osteosarcoma via down-regulating IL 6R.
abstract: Osteosarcoma (OS) has become one of the most common primary malignant tumors in the children and adolescents with a poor prognosis owing to its high malignant and metastatic potential. Although increasing evidence indicates that miR-451 could inhibit the growth and metastasis of OS, its effect on angiogenesis in OS is still very poor. What is more, the mechanism by which miR-451 affects the OS has not been fully elucidated. In the present study, miR-451 was reduced in human osteosarcoma tissues compared with the adjacent bone tissues, and the introduction of miR-451 dramatically inhibited the growth, migration and angiogenesis in OS. Additionally, it was suggested that IL 6R is a direct target gene of miR-451. Silencing of IL 6R suppressed the growth, migration and angiogenesis of OS, which was consistent with the effect of overexpression of miR-451. In conclusion, our data demonstrate that miR-451 may function as a potential suppressor of tumor growth, migration and angiogenesis in OS via down-regulating IL 6R, suggesting a promising therapeutic avenue for managing OS.
authors.affiliation: Department of Orthopeadics and Traumatology, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue (N), Guangzhou 510515, China.
authors.forename: Sheng-Yao
authors.initials: SY
authors.lastname: Liu
authors.affiliation: Department of Orthopeadics and Traumatology, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue (N), Guangzhou 510515, China.
authors.forename: Song-Yun
authors.initials: SY
authors.lastname: Deng
authors.affiliation: Department of Orthopeadics and Traumatology, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue (N), Guangzhou 510515, China.
authors.forename: Yong-Bin
authors.initials: YB
authors.lastname: He
authors.affiliation: Department of Orthopeadics and Traumatology, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue (N), Guangzhou 510515, China; Department of Rehabilitation Medicine, First Affiliated Hospital, Fujian Medical University, 20 Chazhong Road, Fuzhou 350005, China. Electronic address: liushengyao2016@163.com.
authors.forename: Guo-Xin
authors.initials: GX
authors.lastname: Ni
mesh_terms: D000818:Animals; D001483:Base Sequence; D001859:Bone Neoplasms / Q000098:blood supply / Q000235:genetics* / Q000473:pathology; D001842:Bone and Bones / Q000098:blood supply / Q000378:metabolism / Q000473:pathology*; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D015536:Down-Regulation; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D035683:MicroRNAs / Q000235:genetics*; D009389:Neovascularization, Pathologic / Q000235:genetics* / Q000473:pathology; D012516:Osteosarcoma / Q000098:blood supply / Q000235:genetics* / Q000473:pathology; D019947:Receptors, Interleukin-6 / Q000235:genetics*
chemical_list: C531201:MIRN451 microRNA, human; D035683:MicroRNAs; D019947:Receptors, Interleukin-6
keywords: Angiogenesis; Growth; IL-6R; Migration; Osteosarcoma; miR-451