title: Minimally invasive oesophagectomy versus open esophagectomy for resectable esophageal cancer: a meta-analysis.
abstract: BACKGROUND
  Open esophagectomy (OE) is associated with significant morbidity and mortality. Minimally invasive oesophagectomy (MIO) reduces complications in resectable esophageal cancer. The aim of this study is to explore the superiority of MIO in reducing complications and in-hospital mortality than OE.
  
  
  METHODS
  MEDLINE, Embase, Science Citation Index, Wanfang, and Wiley Online Library were thoroughly searched. Odds ratio (OR)/weighted mean difference (WMD) with a 95% confidence interval (CI) was used to assess the strength of association.
  
  
  RESULTS
  Fifty-seven studies containing 15,790 cases of resectable esophageal cancer were included. MIO had less intraoperative blood loss, short hospital stay, and high operative time (P < 0.05) than OE. MIO also had reduced incidence of total complications; (OR = 0.700, 95% CI = 0.626 ~ 0.781, PV< 0.05), pulmonary complications (OR = 0.527, 95% CI = 0431 ~ 0.645, PV< 0.05), cardiovascular complications (OR = 0.770, 95% CI = 0.681 ~ 0.872, PV< 0.05), and surgical technology related (STR) complications (OR = 0.639, 95% CI = 0.522 ~ 0.781, PV< 0.05), as well as lower in-hospital mortality (OR = 0.668, 95% CI = 0.539 ~ 0.827, PV< 0.05). However, the number of harvested lymph nodes, intensive care unit (ICU) stay, gastrointestinal complications, anastomotic leak (AL), and recurrent laryngeal nerve palsy (RLNP) had no significant difference.
  
  
  CONCLUSIONS
  MIO is superior to OE in terms of perioperative complications and in-hospital mortality.
authors.affiliation: Department of Thoracic Surgery, Tumor Hospital of Xinjiang Medical University, Urumqi, China.
authors.forename: Waresijiang
authors.initials: W
authors.lastname: Yibulayin
authors.affiliation: Department of Thoracic Surgery, Tumor Hospital of Xinjiang Medical University, Urumqi, China.
authors.forename: Sikandaer
authors.initials: S
authors.lastname: Abulizi
authors.affiliation: Department of Thoracic Surgery, Tumor Hospital of Xinjiang Medical University, Urumqi, China.
authors.forename: Hongbo
authors.initials: H
authors.lastname: Lv
authors.affiliation: Department of Thoracic Surgery, Tumor Hospital of Xinjiang Medical University, Urumqi, China. yuan2559052@163.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Sun
mesh_terms: D016063:Blood Loss, Surgical / Q000706:statistics & numerical data; D004938:Esophageal Neoplasms / Q000401:mortality* / Q000601:surgery*; D016629:Esophagectomy / Q000009:adverse effects / Q000379:methods*; D017052:Hospital Mortality; D006801:Humans; D007902:Length of Stay; D019060:Minimally Invasive Surgical Procedures / Q000009:adverse effects / Q000379:methods*; D016017:Odds Ratio; D061646:Operative Time; D011183:Postoperative Complications / Q000453:epidemiology*; D016896:Treatment Outcome
keywords: Complications; Minimally invasive esophagectomy; Mortality; Open esophagectomy