title: Tailoring the physicochemical and shape memory properties of the biodegradable polymer poly(glycerol dodecanoate) via curing conditions.
abstract: A major challenge in the repair and regeneration of soft tissue damage occurring as a result of aging, injury, or disease is recapitulating the biomechanical properties of the native tissue. Ideally, a candidate biomaterial for soft tissue engineering applications should be biocompatible, nonlinearly elastic to match soft tissue mechanical behavior, biodegradable to enable tissue remodeling, and tailorable to achieve a range of nonlinear elastic mechanical properties to match specific soft tissues. In addition, for cardiac and other applications, the biomaterial should have shape memory characteristics to facilitate minimally invasive and/or catheter-based delivery. Poly(glycerol dodecanoate) (PGD) is a shape memory material that has nonlinear elastic properties at body temperature and elastic-plastic behavior at room temperature. In this study, we investigated the effects of curing conditions on the nonlinear elastic, shape memory, and biocompatibility properties of PGD. Increased curing and crosslinking resulted in an increase in both the initial stiffness and the nonlinear strain stiffening behavior of PGD. After shape fixation at 60% strain, 100% shape recovery was achieved within 1 min at body temperature for all conditions tested. Polymer curing had no adverse effects on the cellular biocompatibility or non-hemolytic characteristics of PGD, indicating the potential suitability of these formulations for blood-contacting device applications. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 1618-1623, 2017.
authors.affiliation: Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan.
authors.forename: Loran D
authors.initials: LD
authors.lastname: Solorio
authors.affiliation: Department of Pediatrics, Division of Pediatric Cardiology, University of Michigan Health System, Ann Arbor, Michigan.
authors.forename: Martin L
authors.initials: ML
authors.lastname: Bocks
authors.affiliation: Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan.|Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan.|Department of Surgery, University of Michigan, Ann Arbor, Michigan.
authors.forename: Scott J
authors.initials: SJ
authors.lastname: Hollister
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D049109:Cell Proliferation; D005347:Fibroblasts / Q000166:cytology; D008422:Materials Testing; D011091:Polyesters / Q000737:chemistry*; D011817:Rabbits; D023822:Tissue Engineering; D054457:Tissue Scaffolds / Q000737:chemistry; D044366:Transition Temperature
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; C547113:poly(glycerol-dodecanoate)
keywords: bioresorbable; elastomer; minimally invasive; poly(glycerol dodecanoate); shape memory