title: Macrophages participate in local and systemic inflammation induced by amorphous silica nanoparticles through intratracheal instillation.
abstract: Silica nanoparticles (SiNPs) are amongst the most commonly used materials in the field of nanomedicine and, therefore, their influence on organisms has drawn increasing attention in recent years. Most reports have focused on the single tissue reactions induced by SiNPs. Herein, the reaction of primary organs to SiNPs following intratracheal instillation in mice was analyzed by histopathology and ultrastructure observation. Following elucidation of the role of macrophages in local and systemic inflammation, the underlying mechanisms were explored using a macrophage cell line in vitro. The results suggest that macrophages swallow the SiNPs and secrete inflammatory factors by activating the NLRP3 inflammasome, thus participating in local and systemic inflammation.
authors.affiliation: School of Public Health, Capital Medical University, Beijing, People's Republic of China; Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, People's Republic of China.
authors.forename: Man
authors.initials: M
authors.lastname: Yang
authors.affiliation: School of Public Health, Capital Medical University, Beijing, People's Republic of China; Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, People's Republic of China.
authors.forename: Li
authors.initials: L
authors.lastname: Jing
authors.affiliation: School of Public Health, Capital Medical University, Beijing, People's Republic of China; Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, People's Republic of China.
authors.forename: Ji
authors.initials: J
authors.lastname: Wang
authors.affiliation: School of Public Health, Capital Medical University, Beijing, People's Republic of China; Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, People's Republic of China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yu
authors.affiliation: School of Public Health, Capital Medical University, Beijing, People's Republic of China; Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, People's Republic of China.
authors.forename: Lige
authors.initials: L
authors.lastname: Cao
authors.affiliation: School of Public Health, Capital Medical University, Beijing, People's Republic of China; Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, People's Republic of China.
authors.forename: Lianshuang
authors.initials: L
authors.lastname: Zhang
authors.affiliation: School of Public Health, Capital Medical University, Beijing, People's Republic of China; Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, People's Republic of China.
authors.forename: Xianqing
authors.initials: X
authors.lastname: Zhou
authors.affiliation: School of Public Health, Capital Medical University, Beijing, People's Republic of China; Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, People's Republic of China.
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Sun
mesh_terms: D000818:Animals; D002460:Cell Line; D005260:Female; D006321:Heart / Q000187:drug effects; D007249:Inflammation / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000648:ultrastructure; D008168:Lung / Q000187:drug effects / Q000648:ultrastructure; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D008807:Mice, Inbred BALB C; D009206:Myocardium / Q000648:ultrastructure; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry / Q000633:toxicity*; D012822:Silicon Dioxide / Q000737:chemistry
chemical_list: D012822:Silicon Dioxide
keywords: NLRP3 inflammasome; inflammation; macrophages; organs; silica nanoparticles