title: Chikungunya in the Americas: Recommendations and Conclusions.
abstract: Discovered in 1953, chikungunya virus (CHIKV) circulated in Africa and Southeast Asia, with periodic outbreaks, for many years. Highly efficient transmission following a genetic mutation of the virus in 2005 caused its global spread. Associated with significant morbidity, CHIKV creates a large public health burden, and despite various efforts, there are currently no licensed vaccines nor specific treatments. To garner a better understanding of the virus, identify gaps in knowledge, and guide the development of more-effective interventions, the World Health Organization and National Institute of Allergy and Infectious Diseases assembled global experts for discussion and review. Herein described are the outcomes.
authors.affiliation: Vaccine Research Center.
authors.forename: Barney S
authors.initials: BS
authors.lastname: Graham
authors.affiliation: Virology Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
authors.forename: Patricia M
authors.initials: PM
authors.lastname: Repik
authors.affiliation: World Health Organization, Geneva, Switzerland.
authors.forename: Sergio
authors.initials: S
authors.lastname: Yactayo
mesh_terms: D000330:Aedes / Q000821:virology; D000569:Americas; D000818:Animals; D065632:Chikungunya Fever / Q000175:diagnosis / Q000628:therapy* / Q000635:transmission / Q000821:virology; D002646:Chikungunya virus / Q000235:genetics / Q000472:pathogenicity*; D004196:Disease Outbreaks; D006801:Humans; D009154:Mutation; D054579:National Institute of Allergy and Infectious Diseases (U.S.); D017410:Practice Guidelines as Topic; D014481:United States; D014765:Viral Vaccines; D014944:World Health Organization
chemical_list: D014765:Viral Vaccines
keywords: Aedes aegypti; Aedes albopictus; CHIKV; alphavirus; chikungunya; chikungunya virus; virus-like particles