title: Recurrent Cytogenetic Abnormalities in Myeloproliferative Neoplasms and Chronic Myeloid Leukemia.
abstract: The commonest types of myeloproliferative neoplasm (MPN) have remarkably similar recurrent chromosome abnormalities, but with varying incidence and prognostic implications. After a clear decade of treatment of chronic myeloid leukemia (CML) with tyrosine kinase inhibitors, the differing prognostic implications of abnormalities additional to the Ph chromosome are being revealed. This chapter provides a description of the main chromosome abnormalities in MPN and CML and their clinical implications in a time of rapid changes in both the application of new diagnostic techniques and the introduction of targeted therapies.
authors.affiliation: Clinical Cytogenetics Laboratory, The Royal Marsden Hospital, Sutton, Surrey, SM2 5NW, UK. John.swansbury@rmh.nhs.uk.
authors.forename: John
authors.initials: J
authors.lastname: Swansbury
mesh_terms: D002869:Chromosome Aberrations; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*; D058990:Molecular Targeted Therapy; D009196:Myeloproliferative Disorders / Q000175:diagnosis* / Q000235:genetics* / Q000628:therapy; D014178:Translocation, Genetic
keywords: Chromosome; Chronic myeloid leukemia; Cytogenetics; Myeloproliferative