title: Clinicopathological significance of oestrogen receptor expression in non-small cell lung cancer.
abstract: Objective To investigate the expression and clinicopathological significance of the oestrogen receptor (ER) in non-small cell lung cancer (NSCLC). Methods ER expression was examined by immunohistochemical staining of tumour tissue and adjacent normal lung tissue from 67 NSCLC patients. The relationships between ER expression and clinicopathological features were analysed. Results A higher percentage of NSCLC tissues (28/67, 41.79%) than adjacent normal lung tissues (10/55, 18.18%) were ER positive. ER expression correlated with tumour differentiation but not with gender, age, tumour histological type, tumour size, lymph node metastasis, or clinical TNM staging. The median survival times of patients with ER-positive ( n = 28) and -negative ( n = 39) tumours were 36 and 27 months, respectively. The 1-, 3-, and 5-year survival rates were higher for patients with ER-positive tumours than for patients with ER-negative tumours. Conclusion ER expression could be a useful prognostic biomarker and therapeutic target for patients with NSCLC.
authors.affiliation: 1 Department of Respiratory Medicine, Fujian Medical University Union Hospital, Fuzhou 350001, China.|2 Department of Geriatrics, Fujian Medical University Union Hospital, Fuzhou 350001, China.
authors.forename: Xiang-Qi
authors.initials: XQ
authors.lastname: Chen
authors.affiliation: 1 Department of Respiratory Medicine, Fujian Medical University Union Hospital, Fuzhou 350001, China.
authors.forename: Li-Xian
authors.initials: LX
authors.lastname: Zheng
authors.affiliation: 1 Department of Respiratory Medicine, Fujian Medical University Union Hospital, Fuzhou 350001, China.
authors.forename: Zhi-Ying
authors.initials: ZY
authors.lastname: Li
authors.affiliation: 1 Department of Respiratory Medicine, Fujian Medical University Union Hospital, Fuzhou 350001, China.|2 Department of Geriatrics, Fujian Medical University Union Hospital, Fuzhou 350001, China.
authors.forename: Ting-Yan
authors.initials: TY
authors.lastname: Lin
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics*; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D047628:Estrogen Receptor alpha / Q000235:genetics*; D047629:Estrogen Receptor beta / Q000235:genetics*; D005260:Female; D015870:Gene Expression; D006801:Humans; D007150:Immunohistochemistry; D008168:Lung / Q000378:metabolism / Q000473:pathology; D008175:Lung Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011446:Prospective Studies; D016019:Survival Analysis
chemical_list: D014408:Biomarkers, Tumor; C506487:ESR1 protein, human; C000600034:ESR2 protein, human; D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta
keywords: Clinical; estrogen receptor; immunohistochemistry; non-small cell lung cancer; pathology