title: Eco-friendly approach for nanoparticles synthesis and mechanism behind antibacterial activity of silver and anticancer activity of gold nanoparticles.
abstract: This review covers general information about the eco-friendly process for the synthesis of silver nanoparticles (AgNP) and gold nanoparticles (AuNP) and focuses on mechanism of the antibacterial activity of AgNPs and the anticancer activity of AuNPs. Biomolecules in the plant extract are involved in reduction of metal ions to nanoparticle in a one-step and eco-friendly synthesis process. Natural plant extracts contain wide range of metabolites including carbohydrates, alkaloids, terpenoids, phenolic compounds, and enzymes. A variety of plant species and plant parts have been successfully extracted and utilized for AgNP and AuNP syntheses. Green-synthesized nanoparticles eliminate the need for a stabilizing and capping agent and show shape and size-dependent biological activities. Here, we describe some of the plant extracts involved in nanoparticle synthesis, characterization methods, and biological applications. Nanoparticles are important in the field of pharmaceuticals for their strong antibacterial and anticancer activity. Considering the importance and uniqueness of this concept, the synthesis, characterization, and application of AgNPs and AuNPs are discussed in this review.
authors.affiliation: Department of Microbiology, College of Natural Science, Pukyong National University, 45 Yongso-ro, Nam-gu, Busan, 48513, Republic of Korea.
authors.forename: Maheshkumar Prakash
authors.initials: MP
authors.lastname: Patil
authors.affiliation: Department of Microbiology, College of Natural Science, Pukyong National University, 45 Yongso-ro, Nam-gu, Busan, 48513, Republic of Korea. gundokim@pknu.ac.kr.
authors.forename: Gun-Do
authors.initials: GD
authors.lastname: Kim
mesh_terms: D000900:Anti-Bacterial Agents / Q000378:metabolism* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000378:metabolism* / Q000494:pharmacology; D001709:Biotechnology / Q000379:methods*; D006046:Gold / Q000378:metabolism* / Q000494:pharmacology; D055772:Green Chemistry Technology / Q000379:methods*; D053758:Nanoparticles / Q000378:metabolism*; D010936:Plant Extracts / Q000378:metabolism; D012834:Silver / Q000378:metabolism* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D010936:Plant Extracts; D012834:Silver; D006046:Gold
keywords: Antibacterial activity; Anticancer activity; Gold nanoparticles; Green synthesis; Plant extract; Silver nanoparticle