title: Advances in Zika Virus Research: Stem Cell Models, Challenges, and Opportunities.
abstract: The re-emergence of Zika virus (ZIKV) and its suspected link with various disorders in newborns and adults led the World Health Organization to declare a global health emergency. In response, the stem cell field quickly established platforms for modeling ZIKV exposure using human pluripotent stem cell-derived neural progenitors and brain organoids, fetal tissues, and animal models. These efforts provided significant insight into cellular targets, pathogenesis, and underlying biological mechanisms of ZIKV infection as well as platforms for drug testing. Here we review the remarkable progress in stem cell-based ZIKV research and discuss current challenges and future opportunities.
authors.affiliation: Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: gming1@jhmi.edu.
authors.forename: Guo-Li
authors.initials: GL
authors.lastname: Ming
authors.affiliation: Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA.
authors.forename: Hengli
authors.initials: H
authors.lastname: Tang
authors.affiliation: Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: shongju1@jhmi.edu.
authors.forename: Hongjun
authors.initials: H
authors.lastname: Song
mesh_terms: D000818:Animals; D006801:Humans; D008954:Models, Biological; D009420:Nervous System / Q000473:pathology / Q000821:virology; D057905:Stem Cell Research; D013234:Stem Cells / Q000378:metabolism*; D000071244:Zika Virus / Q000502:physiology*; D000071243:Zika Virus Infection / Q000453:epidemiology / Q000235:genetics / Q000473:pathology / Q000821:virology
keywords: SpinΩ; Zika; iPSC; microcephaly; neurogenesis; organoid; outer radial glia cell; radial glia cell