title: Treatment of stroke with early imaging and revascularization: when to be aggressive?
abstract: Neuroimaging has a key role in the assessment and treatment of acute stroke. Cerebral computer tomography is the first step to differentiate hemorragic from ischemic stroke and to detect, in the latter, early signs representative of the lesion severity and predicting a possible hemorrhagic infarction after thrombolytic treatment.Advanced neuroimaging techniques are relevant in the assessment of the ischemic and/or hypo-perfused area, being an essential tool in uncertain situations or when the time of symptoms onset is unavailable, increasing the efficacy and safety of endovenous thrombolysis by enlarging its therapeutic window and leading to more accurate selection of patients to be treated.Moreover, advanced neuroimaging may be of help in choosing the patients to be submitted to endovascular treatment when occlusion of an intracranial artery is documented, either after intravenous thrombolysis or as a primary approach.Here we describe the impact of neuroimaging in the decisional process in acute ischemic stroke, presenting the literature evidence on the topic, especially regarding the recent trials on endovascular treatment.
authors.affiliation: Neurovascular Unit, Policlinico Umberto I, Department of Neurology and Psychiatry, University of Rome, 'La Sapienza', Italy.
authors.forename: Danilo
authors.initials: D
authors.lastname: Toni
authors.forename: Alessio
authors.initials: A
authors.lastname: Pieroni
mesh_terms: D002548:Cerebral Revascularization; D000066491:Clinical Decision-Making; D057510:Endovascular Procedures; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006801:Humans; D059906:Neuroimaging; D018579:Patient Selection; D020521:Stroke / Q000000981:diagnostic imaging / Q000628:therapy*; D017131:Thrombectomy
chemical_list: D005343:Fibrinolytic Agents