title: Tannin-based adhesive for protection of colonic anastomosis in the open abdomen.
abstract: This study was aimed to evaluate the effect of tannin acid- polyethylene glycol (TP) adhesive on the wound healing process of primary colonic anastomosis in the open abdomen (OA). Adhesion strength test, degradation and hemostatic ability of TP were investigated. In a rat model, after standard colonic anastomoses, rats were divided into three groups: OA group; OA + FG (fibrin glue) group; OA + TP group. Five days after surgery, body weight, anastomotic bursting pressure (ABP), and histology of anastomotic tissue were evaluated. Performance of adhesion strength and hemostatic ability of TP was better than that of FG. The weight of TP decreased by over 50% after 11-day incubation. All rats survived well after surgery. Compared to OA group and OA + FG group, OA + TP group showed a significant improvement in body weight, ABP and healing state. Application of TP adhesive, used as an auxiliary treatment of colonic anastomosis operation, improved the wound strength and promoted the anastomotic healing after OA.
authors.affiliation: a Department of General Surgery , Jinling Hospital, Medical School of Nanjing University , Nanjing , P.R. China.
authors.forename: Youming
authors.initials: Y
authors.lastname: Deng
authors.affiliation: a Department of General Surgery , Jinling Hospital, Medical School of Nanjing University , Nanjing , P.R. China.
authors.forename: Jianan
authors.initials: J
authors.lastname: Ren
authors.affiliation: a Department of General Surgery , Jinling Hospital, Medical School of Nanjing University , Nanjing , P.R. China.
authors.forename: Guopu
authors.initials: G
authors.lastname: Chen
authors.affiliation: a Department of General Surgery , Jinling Hospital, Medical School of Nanjing University , Nanjing , P.R. China.
authors.forename: Gefei
authors.initials: G
authors.lastname: Wang
authors.affiliation: a Department of General Surgery , Jinling Hospital, Medical School of Nanjing University , Nanjing , P.R. China.
authors.forename: Guosheng
authors.initials: G
authors.lastname: Gu
authors.affiliation: a Department of General Surgery , Jinling Hospital, Medical School of Nanjing University , Nanjing , P.R. China.
authors.forename: Jieshou
authors.initials: J
authors.lastname: Li
mesh_terms: D000005:Abdomen / Q000601:surgery*; D000269:Adhesives / Q000737:chemistry / Q000494:pharmacology*; D000714:Anastomosis, Surgical / Q000009:adverse effects; D000818:Animals; D003106:Colon / Q000098:blood supply / Q000166:cytology / Q000187:drug effects*; D019610:Cytoprotection / Q000187:drug effects; D006487:Hemostasis / Q000187:drug effects; D008297:Male; D011092:Polyethylene Glycols / Q000737:chemistry; D011312:Pressure; D051381:Rats; D017207:Rats, Sprague-Dawley; D013634:Tannins / Q000737:chemistry / Q000494:pharmacology*; D014945:Wound Healing / Q000187:drug effects
chemical_list: D000269:Adhesives; D013634:Tannins; D011092:Polyethylene Glycols
keywords: Tannin acid; anastomotic healing; colonic anastomosis; open abdomen; wound strength