title: Plasma Phospholipids are Associated with Mild Cognitive Impairment in Type 2 Diabetic Patients.
abstract: Phospholipids and their metabolisms are closely allied to nosogenesis and aggravation of Type 2 diabetes mellitus and cognitive impairment. The aim of this study is to characterize the plasma levels of phospholipids in type 2 diabetes patients and type 2 diabetes patients with mild cognitive impairment (MCI), and to identify potential biomarkers of type 2 diabetes patients with MCI.
  
  
  
  In this cross-sectional study, a total of 374 type 2 diabetes patients were prospectively enrolled. There were 103 patients with MCI and 271 patients without MCI. Plasma levels of lysophosphatidic acid (LPA) and phospholipids with solubility similar to that of LPA (PSS-LPA) were assayed.
  
  
  
  Plasma LPA and PSS-LPA levels were significantly higher in patients with MCI than those without MCI (P = 0.007, P ＜ 0.001). A logistic regression analysis indicates that elevated plasma PSSLPA was associated with increased risk of MCI in type 2 diabetic patients, with an OR of 1.87 (1.04- 3.47) after additional adjustment for hyperlipidemia, hypertension, High-sensitivity C-reactive protein, hemoglobin A1c, Intima-media thickness, ankle brachial index, and brachial-ankle pulse wave velocity. In type 2 diabetic patients with MCI, there were negative correlations between plasma LPA, PSS-LPA and the MoCA scores (r =﹣0.322, P < 0.01; r =﹣0.349, P < 0.001). Furthermore, plasma PSS-LPA exhibited a fair diagnostic value for MCI, with an area under the curve of 0.86.
  
  
  
  The level of plasma PSS-LPA may be an important biomarker for diagnosis of MCI.
authors.affiliation: Department of Neurology, Weihai Municipal Hospital, The Affiliated Hospital of Binzhou Medical College, Weihai, China.
authors.forename: Jin-Biao
authors.initials: JB
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Weihai Municipal Hospital, The Affiliated Hospital of Binzhou Medical College, Weihai, China.
authors.forename: Yan-Nan
authors.initials: YN
authors.lastname: Cong
authors.affiliation: Department of Neurology, Weihai Municipal hOspital, The Affiliated hospital of Binzhou Medical college, 70th Heping street, Weihai 264200, Shandong Province, China.
authors.forename: Zhen-Guang
authors.initials: ZG
authors.lastname: Li
authors.affiliation: Department of Neurology, Weihai Municipal Hospital, The Affiliated Hospital of Binzhou Medical College, Weihai, China.
authors.forename: Hai-Rong
authors.initials: HR
authors.lastname: Sun
authors.affiliation: Department of Neurology, Weihai Municipal Hospital, The Affiliated Hospital of Binzhou Medical College, Weihai, China.
authors.forename: Jiang-Shan
authors.initials: JS
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Weihai Municipal Hospital, The Affiliated Hospital of Binzhou Medical College, Weihai, China.
authors.forename: Peng-Fei
authors.initials: PF
authors.lastname: Wang
authors.affiliation: Department of Neurology, Peking University First Hospital, Beijing, China.
authors.forename: Qi-Zhan
authors.initials: QZ
authors.lastname: Wu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D055109:Ankle Brachial Index; D050197:Atherosclerosis / Q000209:etiology / Q000473:pathology; D002097:C-Reactive Protein / Q000378:metabolism; D059168:Carotid Intima-Media Thickness; D060825:Cognitive Dysfunction / Q000097:blood* / Q000150:complications*; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D008246:Lysophospholipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010743:Phospholipids / Q000097:blood*; D012189:Retrospective Studies
chemical_list: D002097:C-Reactive Protein; D006442:Glycated Hemoglobin; D008246:Lysophospholipids; D010743:Phospholipids; C517652:hemoglobin A1c protein, human; C032881:lysophosphatidic acid
keywords: Phospholipids; biomarker; mild cognitive impairment; plasma; risk factors; type 2 diabetes mellitus