title: Mobilization of Peripheral Blood Stem Cells and Changes in the Concentration of Plasma Factors Influencing their Movement in Patients with Panic Disorder.
abstract: In this paper we examined whether stem cells and factors responsible for their movement may serve as new biological markers of anxiety disorders. The study was carried out on a group of 30 patients diagnosed with panic disorder (examined before and after treatment), compared to 30 healthy individuals forming the control group. We examined the number of circulating HSCs (hematopoetic stem cells) (Lin-/CD45 +/CD34 +) and HSCs (Lin-/CD45 +/AC133 +), the number of circulating VSELs (very small embryonic-like stem cells) (Lin-/CD45-/CD34 +) and VSELs (Lin-/CD45-/AC133 +), as well as the concentration of complement components: C3a, C5a and C5b-9, SDF-1 (stromal derived factor) and S1P (sphingosine-1-phosphate). Significantly lower levels of HSCs (Lin-/CD45 +/AC133 +) have been demonstrated in the patient group compared to the control group both before and after treatment. The level of VSELs (Lin-/CD45-/CD133 +) was significantly lower in the patient group before treatment as compared to the patient group after treatment.The levels of factors responsible for stem cell movement were significantly lower in the patient group compared to the control group before and after treatment. It was concluded that the study of stem cells and factors associated with their movement can be useful in the diagnostics of panic disorder, as well as differentiating between psychotic and anxiety disorders.
authors.affiliation: Department of Psychiatry, Pomeranian University of Medicine, Broniewskiego 26, 71-460, Szczecin, Poland.
authors.forename: Marcin
authors.initials: M
authors.lastname: Jabłoński
authors.affiliation: Department of Psychiatry, Pomeranian University of Medicine, Broniewskiego 26, 71-460, Szczecin, Poland. jola_kucharska@tlen.pl.
authors.forename: Jolanta Kucharska
authors.initials: JK
authors.lastname: Mazur
authors.affiliation: Department of Physiology, Pomeranian University of Medicine, Szczecin, Poland.
authors.forename: Maciej
authors.initials: M
authors.lastname: Tarnowski
authors.affiliation: Department of Medical Analytics, Pomeranian University of Medicine, Szczecin, Poland.
authors.forename: Barbara
authors.initials: B
authors.lastname: Dołęgowska
authors.affiliation: Department of Physiology, Pomeranian University of Medicine, Szczecin, Poland.
authors.forename: Daniel
authors.initials: D
authors.lastname: Pędziwiatr
authors.affiliation: Department of Physiology, Pomeranian University of Medicine, Szczecin, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Kubiś
authors.affiliation: Department of Medical Analytics, Pomeranian University of Medicine, Szczecin, Poland.
authors.forename: Marta
authors.initials: M
authors.lastname: Budkowska
authors.affiliation: Department of Medical Analytics, Pomeranian University of Medicine, Szczecin, Poland.
authors.forename: Daria
authors.initials: D
authors.lastname: Sałata
authors.affiliation: Department of Psychiatry, Pomeranian University of Medicine, Broniewskiego 26, 71-460, Szczecin, Poland.
authors.forename: Justyna Pełka
authors.initials: JP
authors.lastname: Wysiecka
authors.affiliation: Department of Vascular Surgery, Pomeranian University of Medicine, Szczecin, Poland.
authors.forename: Arkadiusz
authors.initials: A
authors.lastname: Kazimierczak
authors.affiliation: Department of Psychiatry, Pomeranian University of Medicine, Broniewskiego 26, 71-460, Szczecin, Poland.
authors.forename: Artur
authors.initials: A
authors.lastname: Reginia
authors.affiliation: Stem Cell Biology Program at the James Graham Brown Cancer Center, University of Louisville, Louisville, KY, 40202, USA.
authors.forename: Mariusz Z
authors.initials: MZ
authors.lastname: Ratajczak
authors.affiliation: Department of Psychiatry, Pomeranian University of Medicine, Broniewskiego 26, 71-460, Szczecin, Poland.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Samochowiec
mesh_terms: D000071916:AC133 Antigen / Q000097:blood; D000328:Adult; D018952:Antigens, CD34 / Q000097:blood; D001008:Anxiety Disorders / Q000097:blood / Q000473:pathology; D002452:Cell Count; D002465:Cell Movement; D054377:Chemokine CXCL12 / Q000097:blood; D003165:Complement System Proteins / Q000378:metabolism; D005260:Female; D005434:Flow Cytometry; D019650:Hematopoietic Stem Cell Mobilization; D006801:Humans; D017493:Leukocyte Common Antigens / Q000097:blood; D008297:Male; D008875:Middle Aged; D016584:Panic Disorder / Q000097:blood* / Q000473:pathology; D000072916:Peripheral Blood Stem Cells / Q000378:metabolism* / Q000473:pathology; D011618:Psychotic Disorders / Q000097:blood / Q000473:pathology; D055815:Young Adult
chemical_list: D000071916:AC133 Antigen; D018952:Antigens, CD34; C515255:CXCL12 protein, human; D054377:Chemokine CXCL12; C000606023:PROM1 protein, human; D003165:Complement System Proteins; D017493:Leukocyte Common Antigens
keywords: Complement components; Panic disorder; SDF-1; Sphingosine - 1 – phosphate; Stem cells; VSEL