title: Prescription of oral antidiabetic drugs in Tyrol - Data from the Tyrol diabetes registry 2012-2015.
abstract: Diabetes mellitus affects 9% of the adult population worldwide and the economic burden of the disease is growing exponentially. In type 2 diabetes mellitus (T2DM), when life style interventions fail to achieve treatment targets, oral antidiabetic drugs are prescribed to improve glycemic control. Several new oral antidiabetics have been launched in the last few years, which enlarged the spectrum of available treatment options in T2DM. The present study aimed to examine T2DM treatment patterns in a cohort of 7769 patients recruited from the Diabetes Registry Tyrol (DRT) with at least one visit from 2012-2015. Secondly, the study aimed to evaluate the use of new oral antidiabetics compared to older oral antidiabetics (OAD). It was found that 43.4% of all patients were treated with OAD alone while 21.2% had oral antidiabetics combined with insulin. 19.9% of the study population were treated with insulin or insulin analogs only. 15.3% had no pharmacological treatment. Metformin was used most frequently (47.9% of the study population), followed by gliptines (27.2%). The most common treatment regimen in this population was the dual therapy of metformin and another OAD (17.2%), followed by metformin monotherapy (16.6%) and triple therapy of metformin and two additional OAD (11.0%).
authors.affiliation: Departement, Medical University of Innsbruck, Innsbruck, Austria.
authors.forename: Lukas
authors.initials: L
authors.lastname: Lunger
authors.affiliation: Departement, Medical University of Innsbruck, Innsbruck, Austria.
authors.forename: Andreas
authors.initials: A
authors.lastname: Melmer
authors.affiliation: Departement for Clinical Epidemiology of the Tiroler Landeskliniken, Tirol Kliniken, Innsbruck, Austria.
authors.forename: Willi
authors.initials: W
authors.lastname: Oberaigner
authors.affiliation: Departement for Clinical Epidemiology of the Tiroler Landeskliniken, Tirol Kliniken, Innsbruck, Austria.
authors.forename: Marco
authors.initials: M
authors.lastname: Leo
authors.affiliation: PKA, Private Hospital, Münster, Austria.
authors.forename: Martin
authors.initials: M
authors.lastname: Juchum
authors.affiliation: Departement for Internal Medicine, Hospital Natters, Natters, Austria.
authors.forename: Karin
authors.initials: K
authors.lastname: Pölzl
authors.affiliation: Departement for Internal Medicine, Hospital Hall in Tirol, Hall in Tirol, Austria.
authors.forename: Johannes
authors.initials: J
authors.lastname: Gänzer
authors.affiliation: Departement for Internal Medicine, Hospital Kufstein, Kufstein, Austria.
authors.forename: Martha
authors.initials: M
authors.lastname: Innerebner
authors.affiliation: Departement for Internal Medicine, Hospital Lienz, Lienz, Austria.
authors.forename: Egon
authors.initials: E
authors.lastname: Eisendle
authors.affiliation: Departement for Internal Medicine, Hospital Reutte, Reutte, Austria.
authors.forename: Gertrud
authors.initials: G
authors.lastname: Beck
authors.affiliation: Departement for Internal Medicine, Hospital Schwaz, Schwaz, Austria.
authors.forename: Hermann
authors.initials: H
authors.lastname: Kathrein
authors.affiliation: Departement for Internal Medicine, Hospital St. Johann in Tirol, St. Johann in Tirol, Austria.
authors.forename: Bernhard
authors.initials: B
authors.lastname: Heindl
authors.affiliation: Departement for Internal Medicine, St. Vinzenz Hospital, Zams, Austria.
authors.forename: Hans Robert
authors.initials: HR
authors.lastname: Schönherr
authors.affiliation: Departement for Internal Medicine and Geriatrics, Hospital Hochzirl, Zirl, Austria.
authors.forename: Monika
authors.initials: M
authors.lastname: Lechleitner
authors.affiliation: Departement, Medical University of Innsbruck, Innsbruck, Austria.
authors.forename: Herbert
authors.initials: H
authors.lastname: Tilg
authors.affiliation: Departement, Medical University of Innsbruck, Innsbruck, Austria. Christoph.Ebenbichler@i-med.ac.at.
authors.forename: Christoph
authors.initials: C
authors.lastname: Ebenbichler
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001317:Austria / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000453:epidemiology*; D004338:Drug Combinations; D011307:Drug Prescriptions / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D010818:Practice Patterns, Physicians' / Q000706:statistics & numerical data; D015995:Prevalence; D012042:Registries / Q000706:statistics & numerical data*; D055815:Young Adult
chemical_list: D004338:Drug Combinations; D007004:Hypoglycemic Agents; D007328:Insulin
keywords: Diabetes mellitus; Hypoglycemic Agents; Insulins; Metformin; Registries