title: Control of apoptosis by SMAR1.
abstract: The nuclear matrix associated protein SMAR1 is sensitive to p53 and acts as a stress inducer as well as a regulator in the p53 regulatory network. Depending on the amount of stress SMAR1 stimulates, it can drive the p53 dynamics in the system to various dynamical states which correspond to various cellular states. The behavior of p53 in these dynamical states is found to be multifractal, due to the mostly long range correlations and large scale fluctuations imparted by stress. This fractal behavior is exhibited in the topological properties of the networks constructed from these dynamical states, and is a signature of self-organization to optimize information flow in the dynamics. The assortativity found in these networks is due to perturbation induced by stress, and indicates that the hubs in the time series play a significant role in stress management. SMAR1 can also regulate apoptosis in the presence of HDAC1, depending on the stress induced by it.
authors.affiliation: Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi-110025, India and School of Computational and Integrative Sciences, Jawaharlal Nehru University, New Delhi-110067, India. brojen@jnu.ac.in.
authors.forename: Md Zubbair
authors.initials: MZ
authors.lastname: Malik
authors.affiliation: College of Applied Medical Sciences, University of Ha'il, Ha'il-2440, Kingdom of Saudi Arabia.
authors.forename: Md Jahoor
authors.initials: MJ
authors.lastname: Alam
authors.affiliation: Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi-110025, India.
authors.forename: Romana
authors.initials: R
authors.lastname: Ishrat
authors.affiliation: Bioinformatics Division, Institute of Cytology and Preventive Oncology, 1-7, Sector - 39, Noida 201301, India.
authors.forename: Subhash M
authors.initials: SM
authors.lastname: Agarwal
authors.affiliation: School of Computational and Integrative Sciences, Jawaharlal Nehru University, New Delhi-110067, India. brojen@jnu.ac.in.
authors.forename: R K Brojen
authors.initials: RK
authors.lastname: Singh
mesh_terms: D000465:Algorithms; D017209:Apoptosis / Q000235:genetics*; D002352:Carrier Proteins; D018797:Cell Cycle Proteins / Q000235:genetics* / Q000378:metabolism*; D004249:DNA Damage; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism*; D017709:Fractals; D056284:Histone Deacetylase 1 / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D009687:Nuclear Proteins / Q000235:genetics* / Q000378:metabolism*; D011485:Protein Binding; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D057188:Workflow
chemical_list: C417914:BANP protein, human; D002352:Carrier Proteins; D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D016159:Tumor Suppressor Protein p53; D056284:Histone Deacetylase 1