title: Transcriptional Regulation of Tissue-Resident Lymphocytes.
abstract: Numerous innate and adaptive immune cells reside in non-lymphoid tissues, where they contribute to barrier immunity, tissue homeostasis, and immune regulation. These tissue-resident populations do not recirculate in the blood or lymphatics and adopt a unique phenotype that is distinct from immune cells in the circulation. Tissue residency has been predominantly described for memory CD8+T cells [tissue-resident memory T cells (TRM)], but it is now clear that CD4 T cells, regulatory T (Treg) cells, various innate T cells, and innate lymphoid cells (ILCs) can establish residence in non-lymphoid tissues. Here we highlight distinct and common features of tissue-resident lymphocytes, with a focus on the transcriptional programs that have recently been shown to guide the establishment of tissue residency.
authors.affiliation: Department of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia. Electronic address: lkmackay@unimelb.edu.au.
authors.forename: Laura K
authors.initials: LK
authors.lastname: Mackay
authors.affiliation: Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.
authors.forename: Axel
authors.initials: A
authors.lastname: Kallies
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D001775:Blood Circulation; D005786:Gene Expression Regulation; D006706:Homeostasis; D006801:Humans; D007113:Immunity, Innate; D007156:Immunologic Memory; D016131:Lymphocyte Subsets / Q000276:immunology*; D008221:Lymphoid Tissue / Q000276:immunology*; D016201:Receptors, Lymphocyte Homing / Q000378:metabolism; D059467:Transcriptome
chemical_list: D016201:Receptors, Lymphocyte Homing