title: Versatile pH-response Micelles with High Cell-Penetrating Helical Diblock Copolymers for Photoacoustic Imaging Guided Synergistic Chemo-Photothermal Therapy.
abstract: With high optical absorption efficiency, near infrared (NIR) dyes have been proposed as theranostic agents for fluorescence imaging, photoacoustic imaging (PAI), and photothermal therapy (PTT). However, inherent hydrophobicity and short circulation time of small molecule hinder the further biomedical application. Herein smart amphiphilic copolymer was synthesized containing IR780/camptothecin@poly(ε-caprolactone) (IR780/CPT@PCL) as core, helical poly(phenyl isocyanide) (PPI) blocks as shell with the pH-responsive rhodamine B (RhB) moieties in the core-shell interface. With hydrophilic helical PPI coronas, these micelles present significantly enhanced cell-penetrating capacity that plays a key role in facilitating intracellular delivery of various cargos. By encapsulating CPT and IR780 molecules, the multifunctional self-assemble probe has huge potential to realize functional cooperativity and adaptability for cancer diagnosis and therapy. Thein vitroandin vivoexperimental results demonstrate that the pH-triggered fluorescent responsiveness and strong acoustic generation permit them efficient fluorescent and PA signal sensing for cancer diagnosis. Moreover, with 808 nm laser irradiation, the generated heat significantly improves the drug release from PCL core, leading to synergetic chemo-photothermal therapy and decreases tumor recurrence rates in mice. Overall, the biocompatible multifunctional micelles with these combined advantages can potentially be utilized for PAI guided disease diagnosis and tumor ablation.
authors.affiliation: Department of Polymer Science and Engineering, School of Chemistry and Chemical Engineering, Hefei University of Technology and Anhui Key Laboratory of Advanced Functional Materials and Devices, Hefei, 230009, China.
authors.forename: Shengyu
authors.initials: S
authors.lastname: Shi
authors.affiliation: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, 361102, China.
authors.forename: Yajing
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Polymer Science and Engineering, School of Chemistry and Chemical Engineering, Hefei University of Technology and Anhui Key Laboratory of Advanced Functional Materials and Devices, Hefei, 230009, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Polymer Science and Engineering, School of Chemistry and Chemical Engineering, Hefei University of Technology and Anhui Key Laboratory of Advanced Functional Materials and Devices, Hefei, 230009, China.
authors.forename: Zhihuang
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Polymer Science and Engineering, School of Chemistry and Chemical Engineering, Hefei University of Technology and Anhui Key Laboratory of Advanced Functional Materials and Devices, Hefei, 230009, China.
authors.forename: Yunsheng
authors.initials: Y
authors.lastname: Ding
authors.affiliation: Department of Polymer Science and Engineering, School of Chemistry and Chemical Engineering, Hefei University of Technology and Anhui Key Laboratory of Advanced Functional Materials and Devices, Hefei, 230009, China.
authors.forename: Zongquan
authors.initials: Z
authors.lastname: Wu
authors.affiliation: Department of Polymer Science and Engineering, School of Chemistry and Chemical Engineering, Hefei University of Technology and Anhui Key Laboratory of Advanced Functional Materials and Devices, Hefei, 230009, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Yin
authors.affiliation: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, 361102, China.
authors.forename: Liming
authors.initials: L
authors.lastname: Nie
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D003131:Combined Modality Therapy; D004195:Disease Models, Animal; D004358:Drug Therapy; D005456:Fluorescent Dyes / Q000008:administration & dosage*; D006367:HeLa Cells; D064593:Heterografts; D006801:Humans; D006979:Hyperthermia, Induced; D051379:Mice; D008823:Micelles; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy*; D061088:Photoacoustic Techniques; D011108:Polymers / Q000008:administration & dosage* / Q000138:chemical synthesis; D012235:Rhodamines / Q000008:administration & dosage*; D000068936:Theranostic Nanomedicine / Q000379:methods; D016896:Treatment Outcome
chemical_list: D005456:Fluorescent Dyes; D008823:Micelles; D011108:Polymers; D012235:Rhodamines; C029773:rhodamine B
keywords: cell penetration; helical poly(phenyl isocyanide); micelles; photoacoustic imaging; theranostics.