title: Neoadjuvant and Adjuvant Therapy for Non-Small Cell Lung Cancer.
abstract: The use of 4 cycles of cisplatin-based adjuvant chemotherapy is now the standard of care for patients with resected stage II and IIIA non-small cell lung cancer. Neoadjuvant chemotherapy lacks the same level of data as adjuvant treatment, but meta-analyses of this approach support its use. Selection of patients who are most likely to benefit from chemotherapy remain elusive. Ongoing adjuvant trials are exploring biomarkers, molecularly targeted agents, postoperative radiation therapy, and immunotherapy.
authors.affiliation: Divisions of Hematology and Oncology, Department of Medicine, Stanford Hospital and Clinics, 875 Blake Wilbur Drive, Stanford, CA 94305, USA.
authors.forename: Jody C
authors.initials: JC
authors.lastname: Chuang
authors.affiliation: First Division, Department of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, No 651, Dongfeng East Road, 16th Floor, Building No 2, Guangzhou, Guangdong 510060, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liang
authors.affiliation: Division of Oncology, Department of Medicine, Stanford Cancer Institute, Stanford University, 875 Blake Wilbur Drive, Room 2233, Stanford, CA 94305-5826, USA. Electronic address: Hwakelee@stanford.edu.
authors.forename: Heather A
authors.initials: HA
authors.lastname: Wakelee
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics / Q000378:metabolism* / Q000628:therapy*; D002945:Cisplatin / Q000627:therapeutic use; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics / Q000378:metabolism / Q000628:therapy*; D020360:Neoadjuvant Therapy / Q000379:methods*
chemical_list: D014408:Biomarkers, Tumor; D002945:Cisplatin
keywords: Adjuvant chemotherapy; Neoadjuvant chemotherapy; Postoperative radiation therapy