title: Catalyst-Controlled Straightforward Synthesis of Highly Substituted Pyrroles/Furans via Propargylation/Cycloisomerization of α-Oxoketene-N,S-acetals.
abstract: A facile and efficient InCl3catalyzed one-pot synthesis of highly substituted pyrroles has been developed via a tandem propargylation/cycloisomerization reaction of α-oxoketene-N,S-acetals with propargyl alcohols. Notably, in the presence of Bronsted acid p-TSA·H2O, the reaction afforded the hydrolyzed product propargylated-1,3-dicarbonyl compounds, which upon treatment with Cs2CO3underwent regioselective intramolecular cyclization furnishing tetrasubstituted furan derivatives.
authors.affiliation: Organic Chemistry Section, Chemical Science and Technology Division, National Institute for Interdisciplinary Science and Technology (CSIR) , Trivandrum, Kerala 695019, India.
authors.forename: Ganesh Chandra
authors.initials: GC
authors.lastname: Nandi
authors.affiliation: Organic Chemistry Section, Chemical Science and Technology Division, National Institute for Interdisciplinary Science and Technology (CSIR) , Trivandrum, Kerala 695019, India.
authors.forename: Soumini
authors.initials: S
authors.lastname: K