title: Androgen Receptor: A Complex Therapeutic Target for Breast Cancer.
abstract: Molecular and histopathological profiling have classified breast cancer into multiple sub-types empowering precision treatment. Although estrogen receptor (ER) and human epidermal growth factor receptor (HER2) are the mainstay therapeutic targets in breast cancer, the androgen receptor (AR) is evolving as a molecular target for cancers that have developed resistance to conventional treatments. The high expression of AR in breast cancer and recent discovery and development of new nonsteroidal drugs targeting the AR provide a strong rationale for exploring it again as a therapeutic target in this disease. Ironically, both nonsteroidal agonists and antagonists for the AR are undergoing clinical trials, making AR a complicated target to understand in breast cancer. This review provides a detailed account of AR's therapeutic role in breast cancer.
authors.affiliation: Department of Medicine, University of Tennessee Health Science Center, Memphis, TN 38103, USA. rnaraya4@uthsc.edu.
authors.forename: Ramesh
authors.initials: R
authors.lastname: Narayanan
authors.affiliation: College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA. daltonjt@umich.edu.
authors.forename: James T
authors.initials: JT
authors.lastname: Dalton
keywords: androgen receptor; breast cancer; estrogen receptor; selective androgen receptor modulator (SARM); triple-negative breast cancer (TNBC)