title: [Application of indocyanine green-fluorescent imaging technique in planning resection line and real-time surgical navigation in small hepatocellular carcinoma].
abstract: Objective:To explore the value of near-infrared technology guided by indolecyanine green(ICG) in planning resection line and real-time surgical navigation in small liver cancer.Methods:From March to September 2015, 11 patients with hepatic tumors received hepatectomy were treated in First Department of Hepatobiliary Surgery, Zhujiang Hospital, Southern Medical University.There were 5 male and 6 female patients with average age of (55±10)years (range 39-70 years). Among whom, there were 9 cases with hepatocellular carcinoma and 2 cases with colorectal cancer. A near-infrared light camera system was used to detect the liver surfaces before resection, and to plan resection line and surgical specimens. A student'sttest was used to compare continuous parametric variables.Results:The ICG-fluorescent imaging and histological examination had been used in the 15 lesions of the 11 patients. Among the 15 lesions, 7 lesions were detected by visual inspections, palpation and ICG-fluorescent imaging, 6 lesions were identified only by ICG-fluorescent imaging, 2 lesions were detected only by ICG-fluorescent imaging after resection.Results of pathologic examination indicated that the total fluorescent type include 5 well differentiated hepatocellular carcinoma and 2 cirrhotic nodule; the partial fluorescent type include 3 moderately differentiated hepatocellular carcinomas and 1 well differentiated hepatocellular carcinomas; the rim fluorescent type included 2 liver metastatic carcinoma and 2 poorly differentiated hepatocellular carcinomas. The average diameter of the tumor size measured by CT was (1.7±0.2)cm, while the average diameter measured by ICG-fluorescent imaging was (1.7±0.3)cm(t=-0.188,P>0.05).Conclusion:Near-infrared technology guided by ICG has important value in planning resection line and real-time surgical navigation in small liver cancer.
authors.affiliation: First Department of Hepatobiliary Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.
authors.forename: C H
authors.initials: CH
authors.lastname: Fang
authors.forename: H B
authors.initials: HB
authors.lastname: Liang
authors.forename: C W
authors.initials: CW
authors.lastname: Chi
authors.forename: H S
authors.initials: HS
authors.lastname: Tao
authors.forename: C
authors.initials: C
authors.lastname: Fang
authors.forename: W
authors.initials: W
authors.lastname: Zhu
authors.forename: Z K
authors.initials: ZK
authors.lastname: Mo
authors.forename: J
authors.initials: J
authors.lastname: Yang
authors.forename: N
authors.initials: N
authors.lastname: Xiang
authors.forename: N
authors.initials: N
authors.lastname: Zeng
authors.forename: J
authors.initials: J
authors.lastname: Tian
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging* / Q000601:surgery; D004396:Coloring Agents; D003952:Diagnostic Imaging / Q000379:methods*; D005260:Female; D005456:Fluorescent Dyes; D006498:Hepatectomy / Q000379:methods*; D006801:Humans; D007208:Indocyanine Green; D007259:Infrared Rays; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery; D008297:Male; D061646:Operative Time; D025321:Surgery, Computer-Assisted / Q000379:methods*
chemical_list: D004396:Coloring Agents; D005456:Fluorescent Dyes; D007208:Indocyanine Green