title: Placental antibody transfer efficiency and maternal levels: specific for measles, coxsackievirus A16, enterovirus 71, poliomyelitis I-III and HIV-1 antibodies.
abstract: Maternal antibodies transported across the placenta can provide vital immunity against infectious pathogens for infants. We here examine maternal antibody (MA) levels and their association with neonatal antibody levels. Pregnant women of gestational age ≥35 weeks were enrolled at a Guangzhou China hospital and mother-infant paired sera were collected. Measles IgG antibody was detected using ELISA assay, neutralizing antibodies titers against coxsackievirus A16 (CA16), enterovirus 71 (EV71), PV I-III and HIV-1 were performed. 711 mother-infant pairs were enrolled and positive relationships for paired serums were found (r: 0.683-0.918). 81.6%, 87.0%, and 82.3% of mothers, and 87.3%, 72.7%, and 72.2% of newborns were positive for measles, CA16 and EV71 antibodies respectively. The highest Neonatal: maternal ratio (NMR) was found in measles (1.042) and the ratios for the other pathogens ranged from 0.84 to 1.00. Linear regressions showed that log(NMR) decreased by a factor of 0.04-15.43 as log(MA) levels increased. A second analysis restricted to maternal positive measles sera revealed that MA measles of was still inversely associated with NMR. Low NMR was found in high MA HIV + serums among 22 paired sera. MA levels appear to play a role determining transplacental antibody transfer; further study is needed to reveal the mechanism.
authors.affiliation: Guangzhou Center for Disease Control and Prevention, Guangzhou, China.
authors.forename: Chuanxi
authors.initials: C
authors.lastname: Fu
authors.affiliation: Liwan District Maternal and Child Health Hospital, Guangzhou, China.
authors.forename: Long
authors.initials: L
authors.lastname: Lu
authors.affiliation: Guangzhou Center for Disease Control and Prevention, Guangzhou, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wu
authors.affiliation: Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Shaman
authors.affiliation: Guangzhou Center for Disease Control and Prevention, Guangzhou, China.
authors.forename: Yimin
authors.initials: Y
authors.lastname: Cao
authors.affiliation: College for Public Health and Social Justice, Saint Louis University, Saint Louis, USA.
authors.forename: Fang
authors.initials: F
authors.lastname: Fang
authors.affiliation: Guangzhou Center for Disease Control and Prevention, Guangzhou, China.
authors.forename: Qiongying
authors.initials: Q
authors.lastname: Yang
authors.affiliation: Guangzhou Center for Disease Control and Prevention, Guangzhou, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: He
authors.affiliation: Guangzhou Center for Disease Control and Prevention, Guangzhou, China.
authors.forename: Zhicong
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Guangzhou Center for Disease Control and Prevention, Guangzhou, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Wang
mesh_terms: D057134:Antibodies, Neutralizing / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood*; D004770:Enterovirus / Q000276:immunology*; D029821:Enterovirus A, Human / Q000276:immunology; D005260:Female; D015483:HIV Antibodies / Q000097:blood*; D006801:Humans; D007112:Immunity, Maternally-Acquired; D007231:Infant, Newborn; D008459:Measles virus / Q000276:immunology*; D010920:Placenta / Q000276:immunology / Q000378:metabolism*; D017955:Poliovirus / Q000276:immunology; D011247:Pregnancy; D016036:Seroepidemiologic Studies; D012959:Socioeconomic Factors
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D015483:HIV Antibodies