title: Influence of weight at enterostomy reversal on surgical outcomes in infants after emergent neonatal stoma creation.
abstract: OBJECTIVE
  Neonates after emergent enterostomy creation frequently require reversal at low weight because of complications including cholestasis, dehydration, dumping, failure to thrive, and failure to achieve enteral independence. We investigated whether stoma reversal at low weight (< 2.5kg) is associated with poor surgical outcomes.
  
  
  METHODS
  Patients who underwent enterostomy reversal from 2005 to 2013 at less than 6months old were identified in our institutional database. Only patients who underwent emergent enterostomy creation (i.e. for necrotizing enterocolitis or spontaneous perforation) were included. Demographics, disease process, comorbidities, stoma type, reversal indication, operative details, and complications were examined. Patients were categorized by weight at reversal of less than 2kg, 2.01-2.5kg, 2.51-3.5kg, and greater than 3.5kg. Data were analyzed using univariable and multivariable regression with significance level of p<0.05. The primary outcome examined was major morbidity, defined as the presence of anastomotic leak, obstruction, hernia, EC fistula, perforation, wound infection, sepsis, or death.
  
  
  RESULTS
  Eighty-nine patients met inclusion criteria. Demographics (sex, ethnicity, surgical disease process, reversal indication, and ASA score) were similar. The lowest weight group had lower gestational age (p<0.001) and birth weight (p=0.005), and contained a higher proportion of jejunostomies to ileostomies (p=0.013). On univariable analysis, only incisional hernia was significantly different as a complication between weight groups. On multivariable analysis controlling for gestational age and ASA, there was no significant difference in odds of major operative morbidity between groups.
  
  
  CONCLUSIONS
  Enterostomy reversal at lower weight may not be associated with increased risk of perioperative complications. Early stoma reversal may be acceptable when required for progression of neonatal care.
  
  
  METHODS
  Level III, Treatment Study (Retrospective comparative study).
authors.affiliation: Nationwide Children's Hospital, Columbus, OH, USA. Electronic address: lindsay.talbot@nationwidechildrens.org.
authors.forename: Lindsay J
authors.initials: LJ
authors.lastname: Talbot
authors.affiliation: Department of Surgery, Duke University Medical Center, Durham, NC, USA.
authors.forename: Robert D
authors.initials: RD
authors.lastname: Sinyard
authors.affiliation: Department of Surgery, Duke University Medical Center, Durham, NC, USA.
authors.forename: Kristy L
authors.initials: KL
authors.lastname: Rialon
authors.affiliation: Department of Surgery, Duke University Medical Center, Durham, NC, USA.
authors.forename: Brian R
authors.initials: BR
authors.lastname: Englum
authors.affiliation: Division of Pediatric Surgery, Duke University Medical Center, Durham, NC, USA.
authors.forename: Elizabeth T
authors.initials: ET
authors.lastname: Tracy
authors.affiliation: Division of Pediatric Surgery, Duke University Medical Center, Durham, NC, USA.
authors.forename: Henry E
authors.initials: HE
authors.lastname: Rice
authors.affiliation: Division of Pediatric Surgery, Duke University Medical Center, Durham, NC, USA.
authors.forename: Obinna O
authors.initials: OO
authors.lastname: Adibe
mesh_terms: D001724:Birth Weight; D001835:Body Weight; D002779:Cholestasis / Q000209:etiology; D020345:Enterocolitis, Necrotizing / Q000601:surgery; D004766:Enterostomy / Q000009:adverse effects; D005260:Female; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007416:Intestinal Perforation / Q000601:surgery; D008297:Male; D011183:Postoperative Complications; D012086:Reoperation; D012189:Retrospective Studies; D054047:Surgical Stomas; D016896:Treatment Outcome
keywords: Cholestasis; Enterostomy closure; Enterostomy reversal; Ileostomy; Jejunostomy; Neonatal; Nutrition