title: Aspirin adherence during high-risk pregnancies, a questionnaire study.
abstract: OBJECTIVE
  Aspirin reduces the risk of recurrent hypertensive disorders of pregnancy (HD) and fetal growth restriction (FGR). This study examined the non-adherence rates of aspirin in women with high-risk pregnancies.
  
  
  METHODS
  All consecutive women between 24 and 36weeks gestation with an indication for aspirin use during pregnancy were invited for this study. A survey was used which included two validated questionnaires, the simplified medication adherence questionnaire (SMAQ) and the Beliefs and Behaviour Questionnaire (BBQ).
  
  
  METHODS
  To determine the non-adherence rates of aspirin, and to identify the beliefs and behavior concerning aspirin.
  
  
  RESULTS
  Indications for aspirin use during pregnancy were previous HD, FGR, intrauterine fetal death or current maternal disease. Non-adherence rates according to the SMAQ and BBQ were 46.3% and 21.4% respectively. No differences in demographic background or obstetrical characteristics between adherent and non-adherent women could be demonstrated.
  
  
  CONCLUSIONS
  Adherence for aspirin in this high-risk population cannot be taken for granted. The non-adherence rates in pregnant women are comparable with the non-adherence rates for aspirin in the non-pregnant population.
authors.affiliation: Department of Obstetrics and Gynecology, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands. Electronic address: c.abheiden@vumc.nl.
authors.forename: Carolien Nienke Heleen
authors.initials: CN
authors.lastname: Abheiden
authors.affiliation: Department of Obstetrics and Gynecology, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands. Electronic address: a.vanreuler@vumc.nl.
authors.forename: Alexandra Vera Ruth
authors.initials: AV
authors.lastname: van Reuler
authors.affiliation: Department of Internal Medicine, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands. Electronic address: w.fuijkschot@vumc.nl.
authors.forename: Wessel Willem
authors.initials: WW
authors.lastname: Fuijkschot
authors.affiliation: Department of Obstetrics and Gynecology, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands. Electronic address: jip.devries@vumc.nl.
authors.forename: Johanna Inge Petra
authors.initials: JI
authors.lastname: de Vries
authors.affiliation: Department of Internal Medicine, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands. Electronic address: a.thijs@vumc.nl.
authors.forename: Abel
authors.initials: A
authors.lastname: Thijs
authors.affiliation: Department of Obstetrics and Gynecology, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands. Electronic address: m.deboer2@vumc.nl.
authors.forename: Marjon Alina
authors.initials: MA
authors.lastname: de Boer
mesh_terms: D000328:Adult; D001241:Aspirin / Q000627:therapeutic use*; D005260:Female; D005313:Fetal Death / Q000517:prevention & control; D005317:Fetal Growth Retardation / Q000523:psychology; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000517:prevention & control; D055118:Medication Adherence; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D011247:Pregnancy; D018566:Pregnancy, High-Risk; D011446:Prospective Studies; D011795:Surveys and Questionnaires
chemical_list: D010975:Platelet Aggregation Inhibitors; D001241:Aspirin
keywords: Acetylsalicylic-acid; Adherence; Aspirin; Compliance; High-risk pregnancy; Hypertensive disorders of pregnancy