title: Tracking silver delivery to bacteria using turn-on fluorescence.
abstract: Herein we present a novel silver complex [Ag(qBODIPY)(CF3SO3)] (1) that exhibits dramatic increase in fluorescence upon silver release. Complex 1 has a minimum inhibitory concentration comparable to that of silver nitrate. Confocal microscopy was used to track the delivery of silver to bacterial targets.
authors.affiliation: Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA. pradip@ucsc.edu.
authors.forename: Miguel N
authors.initials: MN
authors.lastname: Pinto
authors.affiliation: Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA. pradip@ucsc.edu.
authors.forename: Indranil
authors.initials: I
authors.lastname: Chakraborty
authors.affiliation: Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA. pradip@ucsc.edu.
authors.forename: Wiley
authors.initials: W
authors.lastname: Schultz-Simonton
authors.affiliation: Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA. pradip@ucsc.edu.
authors.forename: Mauricio
authors.initials: M
authors.lastname: Rojas-Andrade
authors.affiliation: Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA. pradip@ucsc.edu.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Braslau
authors.affiliation: Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA. pradip@ucsc.edu.
authors.forename: Pradip K
authors.initials: PK
authors.lastname: Mascharak
mesh_terms: D000900:Anti-Bacterial Agents / Q000032:analysis* / Q000737:chemistry / Q000494:pharmacology; D018360:Crystallography, X-Ray; D016503:Drug Delivery Systems; D004926:Escherichia coli / Q000166:cytology / Q000187:drug effects; D005453:Fluorescence; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D009942:Organometallic Compounds / Q000032:analysis* / Q000378:metabolism / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012834:Silver / Q000032:analysis* / Q000378:metabolism / Q000494:pharmacology; D012835:Silver Nitrate / Q000008:administration & dosage / Q000032:analysis* / Q000737:chemistry / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D009942:Organometallic Compounds; D012834:Silver; D012835:Silver Nitrate