title: GH/IGF-I/insulin system in centenarians.
abstract: The endocrine system plays a major role in the regulation of several biological activity and in the ageing process. Evolutionary conservation of GH/IGF-I/insulin pathway from worms to mice and similarities in this system between mice and humans raised expectations that downregulated activity of the GH/IGF-I/insulin pathway could be beneficial for the extension of human life span. Centenarians represent the best example of successful ageing having reached the very extremes of the human life span, escaping and delaying the occurrence of several fatal age-related diseases, such as cancer and cardiovascular diseases. This review describes the endocrine profile of centenarians concerning the GH/IGF-I/insulin system, focusing on the relevance of this pathway on the modulation of ageing and longevity.
authors.affiliation: Department of Clinical Sciences and Community Health (DISCCO), University of Milan, Milan, Italy; Laboratory of Endocrine and Metabolic Research, Istituto Auxologico Italiano IRCCS, Milan, Italy. Electronic address: giovanni.vitale@unimi.it.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Vitale
authors.affiliation: Department of Medical, Surgical, Neurological, Metabolic and Geriatric Sciences, Second University of Naples, Naples, Italy.
authors.forename: Michelangela
authors.initials: M
authors.lastname: Barbieri
authors.affiliation: Department of Clinical Sciences and Community Health (DISCCO), University of Milan, Milan, Italy.
authors.forename: Marina
authors.initials: M
authors.lastname: Kamenetskaya
authors.affiliation: Department of Medical, Surgical, Neurological, Metabolic and Geriatric Sciences, Second University of Naples, Naples, Italy. Electronic address: giuseppe.paolisso@unina2.it.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Paolisso
mesh_terms: D000369:Aged, 80 and over; D004703:Endocrine System / Q000378:metabolism*; D005260:Female; D019382:Human Growth Hormone / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008136:Longevity / Q000502:physiology*; D008297:Male
chemical_list: D007328:Insulin; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I
keywords: Ageing; Centenarians; IGF-I; Insulin; Longevity