title: Patient-derived xenografts: a relevant preclinical model for drug development.
abstract: Identifying appropriate preclinical cancer models remains a major challenge in increasing the efficiency of drug development. A potential strategy to improve patient outcomes could be selecting the 'right' treatment in preclinical studies performed in patient-derived xenografts (PDXs) obtained by direct implants of surgically resected tumours in mice. These models maintain morphological similarities and recapitulate molecular profiling of the original tumours, thus representing a useful tool in evaluating anticancer drug response. In this review, we will present the state-of-art use of PDXs as a reliable strategy to predict clinical findings. The main advantages and limitations will also be discussed.
authors.affiliation: UOSD SAFU, Department of Research, Diagnosis and Innovative Technologies, Traslational Research Area, Regina Elena National Cancer Institute, Via Elio Chianesi 53, Rome, 00144, Italy.|University of Tuscia, Viterbo, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Pompili
authors.affiliation: UOSD SAFU, Department of Research, Diagnosis and Innovative Technologies, Traslational Research Area, Regina Elena National Cancer Institute, Via Elio Chianesi 53, Rome, 00144, Italy.
authors.forename: Manuela
authors.initials: M
authors.lastname: Porru
authors.affiliation: University of Tuscia, Viterbo, Italy.
authors.forename: Carla
authors.initials: C
authors.lastname: Caruso
authors.affiliation: Oncogenomic and Epigenetic Unit, Regina Elena National Cancer Institute, Rome, Italy.
authors.forename: Annamaria
authors.initials: A
authors.lastname: Biroccio
authors.affiliation: UOSD SAFU, Department of Research, Diagnosis and Innovative Technologies, Traslational Research Area, Regina Elena National Cancer Institute, Via Elio Chianesi 53, Rome, 00144, Italy. carlo.leonetti@ifo.gov.it.
authors.forename: Carlo
authors.identifier: 0000-0002-3526-7827
authors.initials: C
authors.lastname: Leonetti
mesh_terms: D000818:Animals; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology*; D057285:Precision Medicine; D014183:Transplantation, Heterologous; D023041:Xenograft Model Antitumor Assays
keywords: Immunosuppressed mice; Orthotopic; Patient-derived-xenografts; Predictive value; Subcutaneous; Tumor heterogeneity