title: Peri-conception maternal lipid profiles predict pregnancy outcomes.
abstract: In this study, healthy women and those at high-risk of adverse pregnancy outcomes (pre-eclampsia, fetal growth restriction, gestational diabetes) were selected to assess the effect of fatty acid supplementation. The purpose of this paper is to report two novel findings (i) at recruitment the receiver operating characteristic (ROC) for erythrocyte oleic acid predicted spontaneous delivery at 34 weeks gestation (ROC=0.926 n=296) for all women entering the study. Further analysis revealed oleic and all monounsaturated fatty acids were similarly predictive with or without a supplement during the pregnancy. (ii) At delivery, we observed a biomagnification of saturated fatty acids from mother to fetus with the reverse for monounsaturates. The major conclusions are (i) the status of the mother in the months prior to conception is a stronger predictor of preterm delivery than the events during the pregnancy. (ii) Saturated fats may be playing an important function in supporting fetal membrane growth.
authors.affiliation: Neonatal unit, Chelsea and Westminster Hospital, London, Division of Medicine, Imperial college, London, UK.
authors.forename: Enitan
authors.initials: E
authors.lastname: Ogundipe
authors.affiliation: Division of Obstetrics and Gynaecology, Department of Surgery and Cancer, Imperial College London, Chelsea and Westminster Hospital Campus, 369 Fulham Road, London SW10 9NH, UK.
authors.forename: Mark R
authors.initials: MR
authors.lastname: Johnson
authors.affiliation: Division of Medicine, Imperial College London, Chelsea and Westminster Hospital Campus, London, UK.
authors.forename: Yiqun
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Division of Obstetrics and Gynaecology, Department of Surgery and Cancer, Imperial College London, Chelsea and Westminster Hospital Campus, 369 Fulham Road, London SW10 9NH, UK. Electronic address: michael.crawford@imperial.ac.uk.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Crawford
mesh_terms: D019587:Dietary Supplements; D005229:Fatty Acids, Monounsaturated / Q000097:blood*; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D039382:Maternal Nutritional Physiological Phenomena; D008431:Maternal-Fetal Exchange; D019301:Oleic Acid / Q000097:blood*; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology; D047928:Premature Birth / Q000453:epidemiology*; D012372:ROC Curve
chemical_list: D005229:Fatty Acids, Monounsaturated; D015525:Fatty Acids, Omega-3; D019301:Oleic Acid
keywords: Birthweight; Docosahexaenoic acid; Monounsaturated fatty acids; Oleic acids; Pregnancy outcomes; Saturated fatty acids