title: Diagnostic Accuracy of T1-Weighted Dynamic Contrast-Enhanced-MRI and DWI-ADC for Differentiation of Glioblastoma and Primary CNS Lymphoma.
abstract: Glioblastoma and primary CNS lymphoma dictate different neurosurgical strategies; it is critical to distinguish them preoperatively. However, current imaging modalities do not effectively differentiate them. We aimed to examine the use of DWI and T1-weighted dynamic contrast-enhanced-MR imaging as potential discriminative tools.
  
  
  
  We retrospectively reviewed 18 patients with primary CNS lymphoma and 36 matched patients with glioblastoma with pretreatment DWI and dynamic contrast-enhanced-MR imaging. VOIs were drawn around the tumor on contrast-enhanced T1WI and FLAIR images; these images were transferred onto coregistered ADC maps to obtain the ADC and onto dynamic contrast-enhanced perfusion maps to obtain the plasma volume and permeability transfer constant. Histogram analysis was performed to determine the mean and relative ADCmeanand relative 90th percentile values for plasma volume and the permeability transfer constant. Nonparametric tests were used to assess differences, and receiver operating characteristic analysis was performed for optimal threshold calculations.
  
  
  
  The enhancing component of primary CNS lymphoma was found to have significantly lower ADCmean(1.1 × 10-3versus 1.4 × 10-3;P< .001) and relative ADCmean(1.5 versus 1.9;P< .001) and relative 90th percentile values for plasma volume (3.7 versus 5.0;P< .05) than the enhancing component of glioblastoma, but not significantly different relative 90th percentile values for the permeability transfer constant (5.4 versus 4.4;P= .83). The nonenhancing portions of glioblastoma and primary CNS lymphoma did not differ in these parameters. On the basis of receiver operating characteristic analysis, mean ADC provided the best threshold (area under the curve = 0.83) to distinguish primary CNS lymphoma from glioblastoma, which was not improved with normalized ADC or the addition of perfusion parameters.
  
  
  
  ADC was superior to dynamic contrast-enhanced-MR imaging perfusion, alone or in combination, in differentiating primary CNS lymphoma from glioblastoma.
authors.affiliation: From the Departments of Neurology (X.L., A.O., A.A.T.).|Department of Neurology (X.L.), National Neuroscience Institute, Singapore.
authors.forename: X
authors.identifier: 0000-0001-9551-7659
authors.initials: X
authors.lastname: Lin
authors.affiliation: Radiology (M.L., O.B., V.H., J.A.-P., A.I.H., R.J.Y.).
authors.forename: M
authors.identifier: 0000-0003-4288-3238
authors.initials: M
authors.lastname: Lee
authors.affiliation: Radiology (M.L., O.B., V.H., J.A.-P., A.I.H., R.J.Y.).
authors.forename: O
authors.identifier: 0000-0002-2448-1537
authors.initials: O
authors.lastname: Buck
authors.affiliation: Epidemiology and Biostatistics (K.M.W., Z.Z.).
authors.forename: K M
authors.identifier: 0000-0002-4730-0321
authors.initials: KM
authors.lastname: Woo
authors.affiliation: Epidemiology and Biostatistics (K.M.W., Z.Z.).
authors.forename: Z
authors.identifier: 0000-0002-1556-7945
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Radiology (M.L., O.B., V.H., J.A.-P., A.I.H., R.J.Y.).|The Brain Tumor Center (V.H., A.O., A.I.H., R.J.Y.), Memorial Sloan Kettering Cancer Center, New York, New York.
authors.forename: V
authors.identifier: 0000-0003-0252-0694
authors.initials: V
authors.lastname: Hatzoglou
authors.affiliation: From the Departments of Neurology (X.L., A.O., A.A.T.).|The Brain Tumor Center (V.H., A.O., A.I.H., R.J.Y.), Memorial Sloan Kettering Cancer Center, New York, New York.
authors.forename: A
authors.identifier: 0000-0003-4299-3664
authors.initials: A
authors.lastname: Omuro
authors.affiliation: Radiology (M.L., O.B., V.H., J.A.-P., A.I.H., R.J.Y.).
authors.forename: J
authors.identifier: 0000-0002-6283-0558
authors.initials: J
authors.lastname: Arevalo-Perez
authors.affiliation: From the Departments of Neurology (X.L., A.O., A.A.T.).
authors.forename: A A
authors.identifier: 0000-0003-2397-736X
authors.initials: AA
authors.lastname: Thomas
authors.affiliation: Pathology (J.H.).
authors.forename: J
authors.identifier: 0000-0003-4440-3250
authors.initials: J
authors.lastname: Huse
authors.affiliation: Medical Physics (K.P.).
authors.forename: K
authors.identifier: 0000-0002-9841-3078
authors.initials: K
authors.lastname: Peck
authors.affiliation: Radiology (M.L., O.B., V.H., J.A.-P., A.I.H., R.J.Y.).|The Brain Tumor Center (V.H., A.O., A.I.H., R.J.Y.), Memorial Sloan Kettering Cancer Center, New York, New York.
authors.forename: A I
authors.identifier: 0000-0002-1159-2705
authors.initials: AI
authors.lastname: Holodny
authors.affiliation: Radiology (M.L., O.B., V.H., J.A.-P., A.I.H., R.J.Y.) youngr@mskcc.org.|The Brain Tumor Center (V.H., A.O., A.I.H., R.J.Y.), Memorial Sloan Kettering Cancer Center, New York, New York.
authors.forename: R J
authors.identifier: 0000-0001-7003-3017
authors.initials: RJ
authors.lastname: Young
mesh_terms: D000368:Aged; D016543:Central Nervous System Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D005909:Glioblastoma / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D008223:Lymphoma / Q000000981:diagnostic imaging* / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D059906:Neuroimaging / Q000379:methods*; D055420:Perfusion Imaging / Q000379:methods; D012372:ROC Curve; D012189:Retrospective Studies