title: The influence of vitamins E and C and exercise on brain aging.
abstract: Age-related declines in motor and cognitive function have been associated with increases in oxidative stress. Accordingly, interventions capable of reducing the oxidative burden would be capable of preventing or reducing functional declines occurring during aging. Popular interventions such as antioxidant intake and moderate exercise are often recommended to attain healthy aging and have the capacity to alter redox burden. This review is intended to summarize the outcomes of antioxidant supplementation (more specifically of vitamins C and E) and exercise training on motor and cognitive declines during aging, and on measures of oxidative stress. Additionally, we will address whether co-implementation of these two types of interventions can potentially further their individual benefits. Together, these studies highlight the importance of using translationally-relevant parameters for interventions and to study their combined outcomes on healthy brain aging.
authors.affiliation: Center for Neuroscience Discovery, Institute for Healthy Aging, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX 76107, USA.
authors.forename: J Thomas
authors.initials: JT
authors.lastname: Mock
authors.affiliation: Center for Neuroscience Discovery, Institute for Healthy Aging, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX 76107, USA.
authors.forename: Kiran
authors.initials: K
authors.lastname: Chaudhari
authors.affiliation: Center for Neuroscience Discovery, Institute for Healthy Aging, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX 76107, USA.
authors.forename: Akram
authors.initials: A
authors.lastname: Sidhu
authors.affiliation: Center for Neuroscience Discovery, Institute for Healthy Aging, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX 76107, USA. Electronic address: nathalie.sumien@unthsc.edu.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Sumien
mesh_terms: D000367:Age Factors; D000375:Aging / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology / Q000523:psychology; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D000066492:Cognitive Aging; D015444:Exercise; D000073656:Healthy Aging; D006801:Humans; D018384:Oxidative Stress / Q000187:drug effects*; D014810:Vitamin E / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D014810:Vitamin E; D001205:Ascorbic Acid
keywords: Aging; Antioxidants; Brain function; Cognition; Exercise; Motor function; Vitamin C; Vitamin E