title: Cognitive dysfunction in adult patients with neuromyelitis optica: a systematic review and meta-analysis.
abstract: The objective of this study was to investigate cognitive dysfunction in 24-60-year-old neuromyelitis optica (NMO) patients, demographically matched healthy subjects, and MS patients. We conducted a comprehensive literature review of the PubMed, Medline, EMBASE, CNKI, Wan Fang Date, Web of Science, and Cochrane Library databases from inception to May 2016 for case-control studies that reported cognitive test scores in NMO patients, healthy subjects, and MS patients. Outcome measures were cognitive function evaluations, including performance on attention, language, memory, information processing speed, and executive function tests. The meta-analysis included eight studies. NMO patients performed significantly worse on attention (P < 0.00001), language (P = 0.00008), memory (P = 0.00004), information processing speed (P < 0.00001), and executive function tests (P = 0.00009) than healthy subjects. There were no significant differences in performance between NMO patients and MS patients on these tests. This meta-analysis indicates that NMO patients aged 24-60 years have significantly worse cognitive performance than demographically matched healthy subjects. However, this was comparable to the performance of demographically matched MS patients. There is a need for further rigorous randomized controlled trials with focus on elucidating the underlying mechanism of cognitive dysfunction in NMO patients.
authors.affiliation: Non-Coding RNA Center, Medical College of Yangzhou University, Yangzhou, 225001, Jiangsu, China.|Department of Neurology, Northern Jiangsu People's Hospital, Yangzhou, 225001, Jiangsu, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Meng
authors.affiliation: Department of Neurology, Northern Jiangsu People's Hospital, Yangzhou, 225001, Jiangsu, China. neurojun@126.com.|Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, School of Medicine, Yangzhou University, Yangzhou, 225001, Jiangsu, China. neurojun@126.com.
authors.forename: Jun
authors.initials: J
authors.lastname: Xu
authors.affiliation: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, Yunnan, China.
authors.forename: Chenling
authors.initials: C
authors.lastname: Pan
authors.affiliation: Department of Neurology, Northern Jiangsu People's Hospital, Yangzhou, 225001, Jiangsu, China.
authors.forename: Jiaxing
authors.initials: J
authors.lastname: Cheng
authors.affiliation: Department of Neurology, Northern Jiangsu People's Hospital, Yangzhou, 225001, Jiangsu, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Health Management Center, Northern Jiangsu Poeple's Hospital, Yangzhou, 225001, Jiangsu, China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Hong
authors.affiliation: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, Yunnan, China.
authors.forename: Yuehai
authors.initials: Y
authors.lastname: Shen
authors.affiliation: Non-Coding RNA Center, Medical College of Yangzhou University, Yangzhou, 225001, Jiangsu, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Dai
mesh_terms: D000328:Adult; D060825:Cognitive Dysfunction / Q000150:complications* / Q000503:physiopathology; D006801:Humans; D008875:Middle Aged; D009471:Neuromyelitis Optica / Q000150:complications* / Q000503:physiopathology / Q000523:psychology*; D055815:Young Adult
keywords: Cognitive dysfunction; Meta-analysis; Multiple sclerosis; Neuromyelitis optica