title: Heart failure induced by itraconazole.
abstract: OBJECTIVE
  Itraconazole is an antifungal imidazole used for the treatment of aspergillosis. Evidence supporting the association between itraconazole and the onset of congestive heart failure (CHF) is limited and is based on cases reported after drug market release.
  
  
  METHODS
  We report the case of a 76-year-old man with hypertension and COPD GOLD D who experienced heart failure after receiving a new line of treatment with itraconazole. The patient's symptoms resolved completely after the drug's withdrawal and initiation of treatment with diuretic therapy. Using validated algorithms, we concluded that there was a probable association between itraconazole and the onset of CHF.
  
  
  CONCLUSIONS
  The association between the administration of itraconazole and the onset of CHF is difficult to prove. Further observational studies are needed to assess this association. However, based on the available evidence, we should consider this possible adverse effect and even contraindicate this treatment in patients with a structural heart disease.
authors.affiliation: Servicio de Neumología, Hospital de la Santa Creu i Sant Pau, Barcelona, España. Electronic address: a.rodrigotroyano@hotmail.com.
authors.forename: Ana
authors.initials: A
authors.lastname: Rodrigo-Troyano
authors.affiliation: Servicio de Farmacia, Hospital de la Santa Creu i Sant Pau, Barcelona, España.
authors.forename: Marta M
authors.initials: MM
authors.lastname: Mediavilla
authors.affiliation: Servicio de Farmacia, Hospital de la Santa Creu i Sant Pau, Barcelona, España.
authors.forename: Noé
authors.initials: N
authors.lastname: Garin
authors.affiliation: Servicio de Neumología, Hospital de la Santa Creu i Sant Pau, Barcelona, España.
authors.forename: Rosa
authors.initials: R
authors.lastname: Güell
mesh_terms: D000368:Aged; D000935:Antifungal Agents / Q000009:adverse effects*; D006333:Heart Failure / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D017964:Itraconazole / Q000009:adverse effects*; D008297:Male
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole
keywords: Drug-Related Adverse Reactions; Heart failure; Insuficiencia cardíaca; Itraconazol; Itraconazole; Reacciones adversas a medicamentos