title: Transmission of Metabolic Dysfunction Across Generations.
abstract: Recent human and animal studies investigating the roles of the genome, epigenome, and environmental cues have identified associations between offspring predisposition to life-long obesity/metabolic disease and epigenetic modifications such as DNA methylation. This review explores the mechanisms by which maternal exposures impair the health of not only the next generation but also potentially future generations of offspring.
authors.affiliation: Washington University School of Medicine, St. Louis, Missouri.
authors.forename: Kathleen
authors.initials: K
authors.lastname: Jaeger
authors.affiliation: Washington University School of Medicine, St. Louis, Missouri.
authors.forename: Jessica L
authors.initials: JL
authors.lastname: Saben
authors.affiliation: Washington University School of Medicine, St. Louis, Missouri.
authors.forename: Kelle H
authors.initials: KH
authors.lastname: Moley
mesh_terms: D000818:Animals; D019175:DNA Methylation; D052244:Endocrine Disruptors; D044127:Epigenesis, Genetic; D005260:Female; D006657:Histones / Q000378:metabolism; D006801:Humans; D018811:Maternal Exposure; D008431:Maternal-Fetal Exchange; D008659:Metabolic Diseases / Q000235:genetics* / Q000503:physiopathology; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism; D009765:Obesity / Q000235:genetics* / Q000503:physiopathology; D011247:Pregnancy
chemical_list: D052244:Endocrine Disruptors; D006657:Histones