title: Evolution: Enhanced Footing for Snake Limb Development.
abstract: Two groups have studied the loss of limbs in snake evolution by focusing on a long-distance cis-acting enhancer of Sonic Hedgehog. They find a progressive degeneration of binding sites for key transcription factors, mirroring the progressive limblessness occurring in these reptiles.
authors.affiliation: Cancer and Developmental Biology Laboratory, National Cancer Institute, Frederick, MD 21702, USA.
authors.forename: Maria M
authors.initials: MM
authors.lastname: Kaltcheva
authors.affiliation: Cancer and Developmental Biology Laboratory, National Cancer Institute, Frederick, MD 21702, USA. Electronic address: Lewandom@mail.nih.gov.
authors.forename: Mark
authors.initials: M
authors.lastname: Lewandoski
mesh_terms: D000818:Animals; D005075:Biological Evolution; D005399:Fishes / Q000235:genetics; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D051379:Mice; D012911:Snakes / Q000033:anatomy & histology* / Q000235:genetics*