title: Refractory Tamoxifen-Induced Keratopathy Despite Drug Withdrawal.
abstract: OBJECTIVE
  To report a case with refractory tamoxifen-induced keratopathy despite drug withdrawal.
  
  
  METHODS
  Case report.
  
  
  RESULTS
  A 50-year-old woman, diagnosed with bilateral breast cancer underwent mastectomy in 2005. She was treated with tamoxifen citrate from 2005 to 2012. According to her medical history, no corneal abnormalities had been documented during past ophthalmological examinations except low myopia, before initiation of tamoxifen treatment. In 2009, 4 years after start of treatment, she was diagnosed with subepithelium deposits compatible with drug-induced keratopathy. The patient was examined again in 2016, 4 years after withdrawal of the drug with persistent tamoxifen-induced keratopathy.
  
  
  CONCLUSIONS
  Contrary to current literature, it seems that tamoxifen-induced corneal abnormalities may persist for years after drug withdrawal.
authors.affiliation: First Department of Ophthalmology, University of Athens, G. Gennimatas General Hospital, Athens, Greece.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Andreanos
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Oikonomakis
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Droutsas
authors.forename: Myrsini
authors.initials: M
authors.lastname: Petrelli
authors.forename: George
authors.initials: G
authors.lastname: Kymionis
mesh_terms: D001943:Breast Neoplasms / Q000188:drug therapy / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D003316:Corneal Diseases / Q000139:chemically induced* / Q000175:diagnosis; D019573:Epithelium, Corneal / Q000187:drug effects; D004965:Estrogen Antagonists / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008408:Mastectomy; D008875:Middle Aged; D066167:Slit Lamp; D013375:Substance Withdrawal Syndrome; D013629:Tamoxifen / Q000009:adverse effects*; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000187:drug effects
chemical_list: D004965:Estrogen Antagonists; D013629:Tamoxifen