title: Effects of autologous platelet-rich plasma on implantation and pregnancy in repeated implantation failure: A pilot study.
abstract: BACKGROUND
  Repeated implantation failure (RIF) is a major challenge in reproductive medicine and despite several methods that have been described for management, there is little consensus on the most effective one.
  
  
  OBJECTIVE
  This study was conducted to evaluate the effectiveness of platelet-rich plasma in improvement of pregnancy rate in RIF patients.
  
  
  METHODS
  Twenty women with a history of RIF who were candidates for frozen-thawed embryo transfer were recruited in this study. Intrauterine infusion of 0.5 ml of platelet-rich plasma that contained platelet 4-5 times more than peripheral blood sample was performed 48 hrs before blastocyst transfer.
  
  
  RESULTS
  Eighteen participants were pregnant with one early miscarriage and one molar pregnancy. Sixteen clinical pregnancies were recorded and their pregnancies are ongoing.
  
  
  CONCLUSIONS
  According to this study, it seems that platelet-rich plasma is effective in improvement of pregnancy outcome in RIF patients.
authors.affiliation: Department of Obstetrics and Gynecology, Preventive Gynecology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Leila
authors.initials: L
authors.lastname: Nazari
authors.affiliation: Department of Obstetrics and Gynecology, Preventive Gynecology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Saghar
authors.initials: S
authors.lastname: Salehpour
authors.affiliation: Department of Obstetrics and Gynecology, Preventive Gynecology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Sedighe
authors.initials: S
authors.lastname: Hoseini
authors.affiliation: Department of Obstetrics and Gynecology, Preventive Gynecology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Shahrzad
authors.initials: S
authors.lastname: Zadehmodarres
authors.affiliation: Department of Obstetrics and Gynecology, Preventive Gynecology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Ladan
authors.initials: L
authors.lastname: Ajori
keywords: Fertilization in Vitro; Implantation; Platelet-rich plasma; Pregnancy rate; Repeated implantation failure