title: Tintelnotia, a new genus in Phaeosphaeriaceae harbouring agents of cornea and nail infections in humans.
abstract: Phaeosphaeriaceae is a family in the order Pleosporales containing numerous plant pathogens, endophytes, lichenised fungi, and environmental saprobes. A novel genus, Tintelnotia is introduced containing two species, one of which caused an eye infection and several nail infections in humans. All species of Tintelnotia produce conidia in soft pycnidia with a wide ostiole. The generic type species is T. opuntiae causing necrotic spots on cactus plants. The isolates of the human opportunist T. destructans showed variable susceptibility pattern to a panel of common antifungal agents. The MICs of amphotericin B, voriconazole, posaconazole and itraconazole were 1 μg/mL, complemented by an in vitro MEC of 16 μg/mL against caspofungin; the MIC of terbinafine was 0.125 μg/mL. The latter compound contributed to the successful therapy in the ocular mycosis refractory to standard antifungal therapy, the benefit of terbinafine should be highlighted as a therapeutic option especially in difficult-to-treat fungal keratitis.
authors.affiliation: Faculty of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan.
authors.forename: S A
authors.identifier: http://orcid.org/0000-0003-0155-8113
authors.initials: SA
authors.lastname: Ahmed
authors.affiliation: Department of Ophthalmology, Otto von Guericke University, Magdeburg, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Hofmüller
authors.affiliation: Robert Koch Institute, Berlin, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Seibold
authors.affiliation: CBS-KNAW Fungal Biodiversity Centre, Utrecht, The Netherlands.|Institute of Biodiversity and Ecosystem Dynamics, University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: G S
authors.initials: GS
authors.lastname: de Hoog
authors.affiliation: Sesto San Giovanni Hospital, Milan, Italy.
authors.forename: H
authors.initials: H
authors.lastname: Harak
authors.affiliation: Department of Medical Microbiology, Otto von Guericke University, Magdeburg, Germany.
authors.forename: I
authors.initials: I
authors.lastname: Tammer
authors.affiliation: CBS-KNAW Fungal Biodiversity Centre, Utrecht, The Netherlands.
authors.forename: A D
authors.initials: AD
authors.lastname: van Diepeningen
authors.affiliation: Department of Ophthalmology, Otto von Guericke University, Magdeburg, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Behrens-Baumann
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology; D001203:Ascomycota / Q000145:classification / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification*; D000077336:Caspofungin; D003315:Cornea / Q000382:microbiology*; D054714:Echinocandins / Q000494:pharmacology; D015821:Eye Infections, Fungal / Q000188:drug therapy / Q000382:microbiology*; D005260:Female; D006801:Humans; D017964:Itraconazole / Q000494:pharmacology; D007634:Keratitis / Q000188:drug therapy; D055666:Lipopeptides / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009262:Nails / Q000382:microbiology*; D009281:Naphthalenes / Q000494:pharmacology / Q000627:therapeutic use; D010802:Phylogeny; D000077291:Terbinafine; D014230:Triazoles / Q000494:pharmacology; D065819:Voriconazole / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D009281:Naphthalenes; D014230:Triazoles; D017964:Itraconazole; C101425:posaconazole; D000666:Amphotericin B; D000077336:Caspofungin; D000077291:Terbinafine; D065819:Voriconazole
keywords: 
  Phaeosphaeriaceae
  ; 
  Pleosporales
  ; 
  Tintelnotia
  ; coelomycetes; fungal keratitis; onychomycosis; terbinafine