title: Extracellular matrix in epitheliochorial, endotheliochorial and haemochorial placentation and its potential application for regenerative medicine.
abstract: A placenta is defined as structural approximation of maternal and foetal tissues to perform physiological exchange. Associated processes of differentiation and the establishment of its cells take place within the extracellular matrix (ECM) that provides a rich environment of collagens, fibronectins, cytokines and other components. Placental ECM is promising for tissue regeneration purposes, because it has immune tolerance capacities that may cause only minimal rejections of transplants with immunological differences between donor and recipient. However, specific characteristics of ECM during evolution of the structurally very diverse mammalian placenta are not yet revealed. We here address the major aspects of placental types, that is non-invasive (epitheliochorial), medium (endotheliochorial)-to-high (haemochorial) invasive nature of the interhemal barrier between the foetal and maternal blood system as well as their main components of ECM with special reference to species that are commonly used as animal models for human placentation and in the potential applications for regenerative medicine.
authors.affiliation: School of Veterinary Medicine and Animal Science, University of Sao Paulo, Sao Paulo, Brazil.
authors.forename: Ara
authors.initials: A
authors.lastname: da Anunciação
authors.affiliation: School of Veterinary Medicine and Animal Science, University of Sao Paulo, Sao Paulo, Brazil.
authors.forename: A M
authors.initials: AM
authors.lastname: Mess
authors.affiliation: School of Veterinary Medicine and Animal Science, University of Sao Paulo, Sao Paulo, Brazil.
authors.forename: D
authors.initials: D
authors.lastname: Orechio
authors.affiliation: School of Veterinary Medicine and Animal Science, University of Sao Paulo, Sao Paulo, Brazil.
authors.forename: B A
authors.initials: BA
authors.lastname: Aguiar
authors.affiliation: School of Veterinary Medicine and Animal Science, University of Sao Paulo, Sao Paulo, Brazil.
authors.forename: P O
authors.initials: PO
authors.lastname: Favaron
authors.affiliation: School of Veterinary Medicine and Animal Science, University of Sao Paulo, Sao Paulo, Brazil.
authors.forename: M A
authors.initials: MA
authors.lastname: Miglino
mesh_terms: D000818:Animals; D005109:Extracellular Matrix / Q000502:physiology*; D005260:Female; D006801:Humans; D008322:Mammals / Q000502:physiology*; D010920:Placenta / Q000033:anatomy & histology*; D010929:Placentation / Q000502:physiology*; D011247:Pregnancy; D044968:Regenerative Medicine
keywords: Eutheria; bioregeneration; collagen; decellularization; evolution; immune tolerance; mammalia; placenta