title: Comparison of 72-hour fecal fat quantification and the 13C-mixed triglyceride breath test in assessing pancreatic exocrine sufficiency in children with chronic pancreatitis.
abstract: BACKGROUND
  Chronic pancreatitis (CP) in children is still a rare, although increasingly recognized entity. Over the duration of the disease several complications can be observed, two of which are major ones: endo- and exocrine insufficiency. In the medical care of children with CP it is crucial to diagnose the decreased endo- and exocrine function of the pancreas, in order to preserve patients from malnutrition and the failure to thrive. The aim of the study was to compare the usefulness of two indirect methods of assessing the pancreas exocrine function in children with CP.
  
  
  METHODS
  Ninety one patients with CP were enrolled in the study (41 boys, 50 girls, aged 2-17.8 years). Only Patients who had had both the 72-hour fecal fat quantification and the 13C-mixed triglyceride breath test (13C -MTBT) performed were selected. We compared the results of both tests for sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) in detecting exocrine pancreatic insufficiency.
  
  
  RESULTS
  Out of 91 patients, 12 were diagnosed with exocrine pancreatic insufficiency (EPI). The sensitivity of the fecal fat quantification was 50%, the specificity for the test was 100%. PPV and NPV were 100% and 93%, respectively. 13C-MTBT had the sensitivity of 42% and the specificity of 99%. PPV and NPV for the breath test were of 83% and 92%, respectively. No statistically significant discrepancy between the values obtained was found.
  
  
  CONCLUSIONS
  Although the 72-hour fecal fat quantification remains the gold standard in detecting EPI, both of the methods that had been investigated were shown to be comparable regarding sensitivity, specificity, PPV and NPV in assessing pancreas exocrine sufficiency in children with CP. Due to the easier execution of the breath test, both for the patient and for medical personnel, its importance may increase.
authors.affiliation: 1Department of Gastroenterology, Hepatology, Feeding Disorders and Pediatrics, The Children's Health Memorial Institute, Warsaw, Poland, e-mail: k.wejnarska@gmail.com.
authors.forename: Karolina
authors.initials: K
authors.lastname: Wejnarska
authors.affiliation: 1Department of Gastroenterology, Hepatology, Feeding Disorders and Pediatrics, The Children's Health Memorial Institute, Warsaw, Poland.
authors.forename: Elwira
authors.initials: E
authors.lastname: Kołodziejczyk
authors.affiliation: 1Department of Gastroenterology, Hepatology, Feeding Disorders and Pediatrics, The Children's Health Memorial Institute, Warsaw, Poland.
authors.forename: Józef
authors.initials: J
authors.lastname: Ryżko
authors.affiliation: 1Department of Gastroenterology, Hepatology, Feeding Disorders and Pediatrics, The Children's Health Memorial Institute, Warsaw, Poland.
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Oracz
mesh_terms: D000293:Adolescent; D001944:Breath Tests / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D010188:Exocrine Pancreatic Insufficiency / Q000175:diagnosis* / Q000378:metabolism; D005243:Feces / Q000737:chemistry*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010186:Pancreatic Function Tests / Q000379:methods; D050500:Pancreatitis, Chronic / Q000175:diagnosis* / Q000378:metabolism; D012016:Reference Values
keywords:  breath test;  children;  fecal fat quantification ;  pancreatic exocrine insufficiency; chronic pancreatits