title: Direct Oral Anticoagulants: An Overview for the Interventional Radiologist.
abstract: The direct oral anticoagulants (DOACs) have emerged as a good alternative for the treatment of thromboembolic diseases, and their use in clinical practice is increasing rapidly. The DOACs act by blocking the activity of one single step in the coagulation cascade. These drugs act downstream in the common pathway of the coagulation cascade by directly antagonising the action of thrombin or factor Xa. The development of DOACs represents a paradigm shift from the oral vitamin K antagonists such as warfarin. This article aims to describe the properties of the currently available DOACs including pharmacology and dosing. We also address the strategies for periprocedural management and reversal of anticoagulation of patients treated with these agents.
authors.affiliation: Radiology Department, Aintree University Hospitals NHS Foundation Trust, Longmoor Lane, Liverpool, L9 7AL, UK. pradeshkumar@doctors.org.uk.
authors.forename: Pradesh
authors.initials: P
authors.lastname: Kumar
authors.affiliation: Radiology Department, Aintree University Hospitals NHS Foundation Trust, Longmoor Lane, Liverpool, L9 7AL, UK.
authors.forename: Rajeev
authors.initials: R
authors.lastname: Ravi
authors.affiliation: Radiology Department, Aintree University Hospitals NHS Foundation Trust, Longmoor Lane, Liverpool, L9 7AL, UK.
authors.forename: Gaurav
authors.initials: G
authors.lastname: Sundar
authors.affiliation: Haematology Department, Aintree University Hospitals NHS Foundation Trust, Longmoor Lane, Liverpool, L9 7AL, UK.
authors.forename: Caroline
authors.initials: C
authors.lastname: Shiach
mesh_terms: D000284:Administration, Oral; D000925:Anticoagulants / Q000008:administration & dosage / Q000627:therapeutic use*; D006470:Hemorrhage / Q000188:drug therapy; D006801:Humans; D000072177:Radiologists; D015642:Radiology, Interventional; D013923:Thromboembolism / Q000188:drug therapy*
chemical_list: D000925:Anticoagulants
keywords: Anticoagulation; Bleeding; Direct oral anticoagulants; Periprocedural