title: Comparison of neuropathology in Parkinson's disease subjects with and without deep brain stimulation.
abstract: The aim of this postmortem study was to compare, in Parkinson's disease subjects with and without bilateral subthalamic nucleus deep brain stimulation (STN-DBS), the loss of pigmented neurons within the substantia nigra and pathological alpha-synuclein density within the SN and other brain regions.
  
  
  
  PD subjects were identified from the Arizona Study of Aging and Neurodegenerative Disorders database (STN-DBS = 11, non-DBS = 156). Pigmented neuron loss scores within the substantia nigra as well as alpha-synuclein density scores within the substantia nigra and 9 other brain regions were compared, the latter individually and in summary as the Lewy body brain load score.
  
  
  
  DBS subjects had higher alpha-synuclein density scores within the substantia nigra, olfactory bulb, and locus ceruleus, as well as higher total Lewy body brain load scores when compared with non-DBS subjects. No differences in substantia nigra pigmented neuron loss scores were found.
  
  
  
  STN-DBS subjects tend to have higher alpha-synuclein density scores, but do not have a differential loss of substantia nigra pigmented neurons. © 2016 International Parkinson and Movement Disorder Society.
authors.affiliation: Department of Neurological Sciences, Rush University, Chicago, Illinois, USA.
authors.forename: Gian D
authors.initials: GD
authors.lastname: Pal
authors.affiliation: Department of Neurological Sciences, Rush University, Chicago, Illinois, USA.
authors.forename: Bichun
authors.initials: B
authors.lastname: Ouyang
authors.affiliation: Banner Sun Health Research Institute, Sun City, Arizona, USA.
authors.forename: Geidy
authors.initials: G
authors.lastname: Serrano
authors.affiliation: Banner Sun Health Research Institute, Sun City, Arizona, USA.
authors.forename: Holly A
authors.initials: HA
authors.lastname: Shill
authors.affiliation: Department of Neurological Sciences, Rush University, Chicago, Illinois, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Goetz
authors.affiliation: Department of Neurological Sciences, Rush University, Chicago, Illinois, USA.
authors.forename: Glenn
authors.initials: G
authors.lastname: Stebbins
authors.affiliation: Department of Neurological Sciences, Rush University, Chicago, Illinois, USA.
authors.forename: Leo Verhagen
authors.initials: LV
authors.lastname: Metman
authors.affiliation: Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona, USA.
authors.forename: Erika
authors.initials: E
authors.lastname: Driver-Dunckley
authors.affiliation: Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona, USA.
authors.forename: Shyamal H
authors.initials: SH
authors.lastname: Mehta
authors.affiliation: Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona, USA.
authors.forename: John N
authors.initials: JN
authors.lastname: Caviness
authors.affiliation: Banner Sun Health Research Institute, Sun City, Arizona, USA.
authors.forename: Marwan N
authors.initials: MN
authors.lastname: Sabbagh
authors.affiliation: Banner Sun Health Research Institute, Sun City, Arizona, USA.|Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona, USA.
authors.forename: Charles H
authors.initials: CH
authors.lastname: Adler
authors.affiliation: Banner Sun Health Research Institute, Sun City, Arizona, USA.|Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona, USA.
authors.forename: Thomas G
authors.initials: TG
authors.lastname: Beach
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D046690:Deep Brain Stimulation; D005260:Female; D006801:Humans; D008125:Locus Coeruleus / Q000378:metabolism / Q000473:pathology; D008297:Male; D009830:Olfactory Bulb / Q000378:metabolism / Q000473:pathology; D010300:Parkinson Disease / Q000378:metabolism* / Q000473:pathology* / Q000628:therapy; D013378:Substantia Nigra / Q000378:metabolism* / Q000473:pathology*; D020531:Subthalamic Nucleus; D051844:alpha-Synuclein / Q000378:metabolism*
chemical_list: D051844:alpha-Synuclein
keywords: Lewy body; Parkinson's disease; alpha-synuclein; deep brain stimulation; subthalamic nucleus