title: Regulation of protein phosphatase 2A (PP2A) tumor suppressor function by PME-1.
abstract: Protein phosphatase 2A (PP2A) plays a major role in maintaining cellular signaling homeostasis by dephosphorylation of a variety of signaling proteins and acts as a tumor suppressor. Protein phosphatase methylesterase-1 (PME-1) negatively regulates PP2A activity by highly complex mechanisms that are reviewed here. Importantly, recent studies have shown that PME-1 promotes oncogenic MAPK/ERK and AKT pathway activities in various cancer types. In human glioma, high PME-1 expression correlates with tumor progression and kinase inhibitor resistance. We discuss the emerging cancer-associated function of PME-1 and its potential clinical relevance.
authors.affiliation: Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, PO Box 123, Tykistökatu 6, 20520 Turku, Finland.|Department of Pathology, University of Turku, Turku, Finland.
authors.forename: Amanpreet
authors.initials: A
authors.lastname: Kaur
authors.affiliation: Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, PO Box 123, Tykistökatu 6, 20520 Turku, Finland.|Department of Pathology, University of Turku, Turku, Finland.
authors.forename: Jukka
authors.initials: J
authors.lastname: Westermarck
mesh_terms: D000818:Animals; D002265:Carboxylic Ester Hydrolases / Q000378:metabolism*; D006801:Humans; D008745:Methylation; D008954:Models, Biological; D009369:Neoplasms / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D010766:Phosphorylation; D054648:Protein Phosphatase 2 / Q000378:metabolism*; D015398:Signal Transduction; D025521:Tumor Suppressor Proteins / Q000378:metabolism*
chemical_list: D025521:Tumor Suppressor Proteins; D002265:Carboxylic Ester Hydrolases; C119357:protein phosphatase methylesterase-1; D054648:Protein Phosphatase 2
keywords: LCMT-1; PTPA; colorectal cancer; endometrial cancer; glioma; neuroendocrine prostate cancer