title: Parvalbumin neurons and perineuronal nets in the mouse prefrontal cortex.
abstract: The prefrontal cortex (PFC) plays a key role in cognitive functions, memory, and attention. Alterations in parvalbumin interneurons (PV neurons) and perineuronal nets (PNNs) within the PFC have been implicated in schizophrenia and autism spectrum disorder pathology. However, it remains unclear why PV neurons and PNNs in the PFC are selectively impaired. Here we aimed to clarify if PV neurons and PNNs in the PFC have region-specific features. We found that PV neurons and PNNs were increased in a region-specific manner in the PFC during postnatal development. In the mature PFC, the expression of PV protein is lower than in other parts of the cortex. Furthermore, PNNs in the mature PFC are not typical lattice-like structures and do not have the major components of PNNs and tenascin-R. The present study indicates that PV neurons and PNNs have region-specific features, and our results suggest that PV neurons and PNNs have structural vulnerability within the PFC.
authors.affiliation: Department of Medical Technology, Kawasaki College of Allied Health Professions, Okayama 701-0194, Japan; Department of Medical Technology, Graduate School of Health Sciences, Okayama University, Okayama 700-8558, Japan. Electronic address: dhe422007@s.okayama-u.ac.jp.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ueno
authors.affiliation: Department of Psychiatry, Kawasaki Medical School, Kurashiki 701-0192, Japan.
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Suemitsu
authors.affiliation: Department of Medical Technology, Graduate School of Health Sciences, Okayama University, Okayama 700-8558, Japan.
authors.forename: Motoi
authors.initials: M
authors.lastname: Okamoto
authors.affiliation: Department of Neuropsychiatry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan.
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Matsumoto
authors.affiliation: Department of Psychiatry, Kawasaki Medical School, Kurashiki 701-0192, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ishihara
mesh_terms: D000818:Animals; D005109:Extracellular Matrix / Q000378:metabolism*; D005968:Glutamate Decarboxylase / Q000378:metabolism; D007150:Immunohistochemistry; D008297:Male; D008810:Mice, Inbred C57BL; D018613:Microscopy, Confocal; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D010320:Parvalbumins / Q000378:metabolism*; D037121:Plant Lectins / Q000378:metabolism; D017397:Prefrontal Cortex / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism*; D034781:Receptors, N-Acetylglucosamine / Q000378:metabolism
chemical_list: D010320:Parvalbumins; D037121:Plant Lectins; D034781:Receptors, N-Acetylglucosamine; C040129:wisteria lectin; D005968:Glutamate Decarboxylase; C402565:glutamate decarboxylase 1
keywords: parvalbumin; perineuronal nets; plasticity; postnatal development; prefrontal cortex