title: Correlation of (1→3)-β-D-glucan with other inflammation markers in chronically HIV infected persons on suppressive antiretroviral therapy.
abstract: We evaluated associations between levels of BDG and other biomarkers of inflammation in blood from 41 virologically suppressed persons with chronic HIV-infection. We found a significant correlation between BDG and neopterin levels (r=0.68), and trends to significance for correlations with other inflammation markers (tumor-necrosis-factor-α: r=0.30; interleukin-8: r=0.30; interleukin-6: r=0.28). In conclusion, BDG levels correlated with inflammation markers in a cohort of virologically suppressed individuals with chronic HIV infection. Future studies are needed to evaluate whether BDG may be a marker for morbidity in chronic HIV infection.
authors.affiliation: Division of Infectious Diseases, University of California San Diego, San Diego, California, USA; Section of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Medical University of Graz, Graz, Austria; Division of Pulmonology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
authors.forename: Martin
authors.initials: M
authors.lastname: Hoenigl
authors.affiliation: Division of Infectious Diseases, University of California San Diego, San Diego, California, USA.
authors.forename: Michelli Faria
authors.initials: MF
authors.lastname: de Oliveira
authors.affiliation: Division of Infectious Diseases, University of California San Diego, San Diego, California, USA.
authors.forename: Josué
authors.initials: J
authors.lastname: Pérez-Santiago
authors.affiliation: Research Laboratory, Associates of Cape Cod, Inc., Falmouth, Massachusetts, USA.
authors.forename: Yonglong
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Psychology, University of Houston, Texas, USA.
authors.forename: Steven Paul
authors.initials: SP
authors.lastname: Woods
authors.affiliation: Research Laboratory, Associates of Cape Cod, Inc., Falmouth, Massachusetts, USA.
authors.forename: Malcolm
authors.initials: M
authors.lastname: Finkelman
authors.affiliation: Division of Infectious Diseases, University of California San Diego, San Diego, California, USA.
authors.forename: Sara
authors.initials: S
authors.lastname: Gianella
keywords: HIV; beta-D-glucan; interleukin; neopterin; plasma; virologically suppressed