title: Factor Xa Signaling Contributes to the Pathogenesis of Inflammatory Diseases.
abstract: The coagulation protease Factor Xa (FXa) triggers a variety of signaling pathways through activation of protease-activated receptors (PARs) and non-PAR receptors. FXa-mediated signaling is strongly implicated in the pathogenesis of several inflammatory diseases including fibrosis, cardiovascular diseases, and cancer. Thus, targeting of FXa can have great clinical significance in terms of the treatment of these disorders. This review summarizes the current knowledge about the mechanism of FXa signaling in cellular and animal systems under (patho) physiological conditions for a better understanding and hence a better management of FXa-induced disorders. J. Cell. Physiol. 232: 1966-1970, 2017. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Department of Medical Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Safieh
authors.initials: S
authors.lastname: Ebrahimi
authors.affiliation: Department of Medical Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Sara
authors.initials: S
authors.lastname: Rezaei
authors.affiliation: Department of Medical Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Parvaneh
authors.initials: P
authors.lastname: Seiri
authors.affiliation: Department of Molecular Microbiology and Immunology, St. Louis University School of Medicine, Saint Louis, Missouri.
authors.forename: Mikhail
authors.initials: M
authors.lastname: Ryzhikov
authors.affiliation: Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Seyed Isaac
authors.initials: SI
authors.lastname: Hashemy
authors.affiliation: Department of Medical Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.|Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.|Microanatomy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Seyed Mahdi
authors.initials: SM
authors.lastname: Hassanian
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000494:pharmacology; D050197:Atherosclerosis / Q000097:blood / Q000188:drug therapy / Q000378:metabolism*; D015951:Factor Xa / Q000378:metabolism*; D065427:Factor Xa Inhibitors / Q000627:therapeutic use; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000188:drug therapy / Q000378:metabolism*; D018836:Inflammation Mediators / Q000037:antagonists & inhibitors / Q000378:metabolism*; D009369:Neoplasms / Q000097:blood / Q000188:drug therapy / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D065427:Factor Xa Inhibitors; D018836:Inflammation Mediators; D015951:Factor Xa