title: Sensitivity analysis of a pharmaceutical tablet production process from the control engineering perspective.
abstract: This paper presents a sensitivity analysis of a pharmaceutical direct compaction process. Sensitivity analysis is an important tool for gaining valuable process insights and designing a process control concept. Examining its results in a systematic manner makes it possible to assign actuating signals to controlled variables. This paper presents mathematical models for individual unit operations, on which the sensitivity analysis is based. Two sensitivity analysis methods are outlined: (i) based on the so-called Sobol indices and (ii) based on the steady-state gains and the frequency response of the proposed plant model.
authors.affiliation: Institute of Automation and Control, Graz University of Technology, Inffeldgasse 21/B/I, 8010 Graz, Austria; Research Center Pharmaceutical Engineering GmbH, Inffeldgasse 13, 8010 Graz, Austria.
authors.forename: Jakob
authors.initials: J
authors.lastname: Rehrl
authors.affiliation: Research Center Pharmaceutical Engineering GmbH, Inffeldgasse 13, 8010 Graz, Austria.
authors.forename: Arlin
authors.initials: A
authors.lastname: Gruber
authors.affiliation: Research Center Pharmaceutical Engineering GmbH, Inffeldgasse 13, 8010 Graz, Austria; Institute for Particle and Process Engineering, Graz University of Technology, Inffeldgasse 13/III, 8010 Graz, Austria.
authors.forename: Johannes G
authors.initials: JG
authors.lastname: Khinast
authors.affiliation: Institute of Automation and Control, Graz University of Technology, Inffeldgasse 21/B/I, 8010 Graz, Austria. Electronic address: martin.horn@tugraz.at.
authors.forename: Martin
authors.initials: M
authors.lastname: Horn
mesh_terms: D008962:Models, Theoretical; D011786:Quality Control; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000706:statistics & numerical data*
chemical_list: D013607:Tablets
keywords: Dynamic systems; Pharmaceutical manufacturing; Process modeling; Sensitivity analysis