title: β-Cyclodextrin carbon nanotube-enhanced sensor for ciprofloxacin detection.
abstract: A simple and expedite electrochemical methodology was developed for the determination of ciprofloxacin, based on a glassy carbon (GC) electrode modified by a combination of multi-walled carbon nanotubes (MWCNT) with β-cyclodextrin (β-CD) incorporated in a polyaniline film. The combined use of β-CD and MWCNT in the electrochemical sensor leads to a significant signal improvement. The β-CD/MWCNT modified GC electrode exhibited efficient electrocatalytic behavior in the oxidation of ciprofloxacin with relatively high sensitivity, stability and lifetime. Molecular modeling studies showed that ciprofloxacin binds preferably to β-CD rather than to CNT edges, leading to an improved sensitivity of the sensor. Under optimized conditions, a linear calibration curve was obtained for ciprofloxacin in the concentration range 10-80 µM with a detection limit of 50 nM. The analytical performance of this sensor was evaluated for the detection of ciprofloxacin in a wastewater treatment plant effluent.
authors.affiliation: a Department of Chemical Engineering , School of Engineering (ISEP), Polytechnic of Porto , Porto , Portugal.|b CIQ/Department of Chemistry and Biochemistry , Faculty of Sciences, University of Porto , Porto , Portugal.
authors.forename: Jorge M P J
authors.initials: JM
authors.lastname: Garrido
authors.affiliation: c Centro ALGORITMI, Department of Informatics , University of Minho , Braga , Portugal.
authors.forename: Manuel
authors.initials: M
authors.lastname: Melle-Franco
authors.affiliation: c Centro ALGORITMI, Department of Informatics , University of Minho , Braga , Portugal.
authors.forename: Karol
authors.initials: K
authors.lastname: Strutyński
authors.affiliation: b CIQ/Department of Chemistry and Biochemistry , Faculty of Sciences, University of Porto , Porto , Portugal.
authors.forename: Fernanda
authors.initials: F
authors.lastname: Borges
authors.affiliation: d Department of Chemistry , Faculty of Sciences and Technology, University of Coimbra , Coimbra , Portugal.
authors.forename: Christopher M A
authors.initials: CM
authors.lastname: Brett
authors.affiliation: a Department of Chemical Engineering , School of Engineering (ISEP), Polytechnic of Porto , Porto , Portugal.|b CIQ/Department of Chemistry and Biochemistry , Faculty of Sciences, University of Porto , Porto , Portugal.
authors.forename: E Manuela P J
authors.initials: EM
authors.lastname: Garrido
mesh_terms: D002939:Ciprofloxacin / Q000032:analysis*; D004784:Environmental Monitoring / Q000295:instrumentation*; D037742:Nanotubes, Carbon / Q000737:chemistry*; D011174:Portugal; D012722:Sewage / Q000737:chemistry*; D014874:Water Pollutants, Chemical / Q000032:analysis*
chemical_list: D037742:Nanotubes, Carbon; D012722:Sewage; D014874:Water Pollutants, Chemical; D002939:Ciprofloxacin
keywords: Ciprofloxacin; carbon nanotubes; electrochemical sensor; β–cyclodextrin