title: Usefulness of CHADS2score for prognostic stratification of patients with coronary artery disease: A systematic review and meta-analysis of cohort studies.
abstract: OBJECTIVE
  To evaluate the role of CHADS2score on predicting ischaemic stroke or transient ischaemic attack (TIA) and death in patients with coronary artery disease (CAD), irrespective of the presence or absence of atrial fibrillation (AF).
  
  
  METHODS
  We searched for cohort studies that reported risk estimates for incidence of ischaemic stroke/TIA or mortality by levels of CHADS2score in Medline/PubMed and Embase. Random effects models were used to calculate pooled risk ratios (RRs) and 95% confidence intervals (CIs).
  
  
  RESULTS
  Eight cohort studies (7 prospective and 1 retrospective) enrolling 31,509 patients with CAD were included. The pooled RR of mortality was 2.38 (95% CI 1.63-3.47) for CHADS2score≥2, and of stroke/TIA incidence was 2.19 (1.55-3.08). In patients without AF, CHADS2score≥2 was associated with increased mortality (pooled RR 3.14 95% CI 2.14-4.61) and stroke/TIA incidence (pooled 2.81, 2.08-3.78) In patients with AF, the pooled RR of mortality for CHADS2score≥2 was 1.57 (1.07-2.28), but no significant association was found between CHADS2score and stroke/TIA incidence (pooled RR 1.21, 95% CI 0.84-1.73).
  
  
  CONCLUSIONS
  CHADS2score can predict mortality in patients with CAD. However, higher CHADS2score is associated with increased incidence of stroke/TIA only in patients without AF.
authors.affiliation: Department of Cardiology, Dongli Hospital of Dongli District of Tianjin, Tianjin, People's Republic of China. Electronic address: zhxiaobo@sohu.com.
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Department of Cardiology, Dongli Hospital of Dongli District of Tianjin, Tianjin, People's Republic of China. Electronic address: 183580422@qq.com.
authors.forename: Kaiwu
authors.initials: K
authors.lastname: Cao
authors.affiliation: Department of Cardiology, Dongli Hospital of Dongli District of Tianjin, Tianjin, People's Republic of China. Electronic address: 2405893700@qq.com.
authors.forename: Shuangqing
authors.initials: S
authors.lastname: Kou
authors.affiliation: Department of Cardiology, Dongli Hospital of Dongli District of Tianjin, Tianjin, People's Republic of China. Electronic address: 287633353@qq.com.
authors.forename: Shencheng
authors.initials: S
authors.lastname: Qu
authors.affiliation: Department of Nursing, Dongli Hospital of Dongli District of Tianjin, Tianjin, People's Republic of China. Electronic address: lihonglinglhl@163.com.
authors.forename: Hongling
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Cardiology, Dongli Hospital of Dongli District of Tianjin, Tianjin, People's Republic of China. Electronic address: 276137869@qq.com.
authors.forename: Ying
authors.initials: Y
authors.lastname: Yu
authors.affiliation: Department of Cardiology, Dongli Hospital of Dongli District of Tianjin, Tianjin, People's Republic of China. Electronic address: wangcong19840119@126.com.
authors.forename: Cong
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Dongli Hospital of Dongli District of Tianjin, Tianjin, People's Republic of China. Electronic address: yuying0021@sina.com.
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Cardiology, Dongli Hospital of Dongli District of Tianjin, Tianjin, People's Republic of China. Electronic address: 87044339@qq.com.
authors.forename: Pengying
authors.initials: P
authors.lastname: Li
authors.affiliation: Department of Cardiology, Dongli Hospital of Dongli District of Tianjin, Tianjin, People's Republic of China. Electronic address: Ld26615406@163.com.
authors.forename: Dan
authors.initials: D
authors.lastname: Li
mesh_terms: D054058:Acute Coronary Syndrome; D000328:Adult; D000369:Aged, 80 and over; D001281:Atrial Fibrillation / Q000150:complications* / Q000175:diagnosis; D002545:Brain Ischemia / Q000209:etiology / Q000401:mortality* / Q000503:physiopathology; D002423:Cause of Death; D015331:Cohort Studies; D003324:Coronary Artery Disease / Q000150:complications* / Q000175:diagnosis; D005260:Female; D006801:Humans; D002546:Ischemic Attack, Transient / Q000209:etiology / Q000401:mortality / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011237:Predictive Value of Tests; D011379:Prognosis; D012720:Severity of Illness Index; D020521:Stroke / Q000209:etiology* / Q000401:mortality / Q000503:physiopathology; D016019:Survival Analysis
keywords: Atrial fibrillation; CHADS(2) score; Coronary artery disease; Death; Risk ratio; Stroke