title: Muscle PGC-1α modulates satellite cell number and proliferation by remodeling the stem cell niche.
abstract: The myogenic capacity of satellite cells (SCs), adult muscle stem cells, is influenced by aging, exercise, and other factors. In skeletal muscle, the peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) is a key regulator of oxidative metabolism and endurance training adaptation. However, a link between PGC-1α and SC behavior remains unexplored.
  
  
  
  We have now studied SC function in a PGC-1α fiber-specific gain-of-function animal model.
  
  
  
  In surprising contrast to bona fide exercise, muscle-specific PGC-1α transgenic mice have lower SC numbers. Nevertheless, SCs from these mice have a higher propensity for activation and proliferation. Intriguingly, muscle PGC-1α triggers a remodeling of the SC niche by altering the extracellular matrix composition, including the levels of fibronectin, which affects the proliferative output of SCs.
  
  
  
  Taken together, PGC-1α indirectly affects SC plasticity in skeletal muscle and thereby might contribute to improved SC activation in exercise.
authors.affiliation: Biozentrum, University of Basel, Klingelbergstrasse 50/70, 4056, Basel, Switzerland.
authors.forename: Ivana
authors.initials: I
authors.lastname: Dinulovic
authors.affiliation: Biozentrum, University of Basel, Klingelbergstrasse 50/70, 4056, Basel, Switzerland.
authors.forename: Regula
authors.initials: R
authors.lastname: Furrer
authors.affiliation: Biozentrum, University of Basel, Klingelbergstrasse 50/70, 4056, Basel, Switzerland.
authors.forename: Markus
authors.initials: M
authors.lastname: Beer
authors.affiliation: Thérapie des maladies du muscle strié INSERM U974 - CNRS UMR7215 - UPMC UM76 - Institut de Myologie and University Rene Descartes, 47 bld de l'Hôpital, G.H. Pitié-Salpétrière, 75013, Paris, France.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Ferry
authors.affiliation: Biozentrum, University of Basel, Klingelbergstrasse 50/70, 4056, Basel, Switzerland.
authors.forename: Bettina
authors.initials: B
authors.lastname: Cardel
authors.affiliation: Biozentrum, University of Basel, Klingelbergstrasse 50/70, 4056, Basel, Switzerland. christoph.handschin@unibas.ch.
authors.forename: Christoph
authors.identifier: 0000-0003-0603-1097
authors.initials: C
authors.lastname: Handschin
mesh_terms: D000818:Animals; D049109:Cell Proliferation; D002478:Cells, Cultured; D005109:Extracellular Matrix / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / Q000235:genetics / Q000378:metabolism*; D032496:Satellite Cells, Skeletal Muscle / Q000166:cytology / Q000378:metabolism* / Q000502:physiology; D055153:Stem Cell Niche
chemical_list: D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; C485290:Ppargc1a protein, mouse
keywords: Basal lamina; Fibronectin; PGC-1α; Satellite cell niche; Satellite cells; Skeletal muscle