title: Rhodium-Catalyzed Regioselective C7-Olefination of Indazoles Using an N-Amide Directing Group.
abstract: A rhodium-catalyzed regioselective C-H olefination of indazole is described. This protocol relies on the use of an efficient and removable N,N-diisopropylcarbamoyl directing group, which offers facile access to C7-olefinated indazoles with high regioselectivity, ample substrate scope and broad functional group tolerance.
authors.affiliation: School of Perfume and Aroma Technology, Shanghai Institute of Technology, 100 Haiquan Road, Shanghai, 201418, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Guo
authors.affiliation: School of Perfume and Aroma Technology, Shanghai Institute of Technology, 100 Haiquan Road, Shanghai, 201418, China.
authors.forename: Yanyu
authors.initials: Y
authors.lastname: Chen
authors.affiliation: School of Perfume and Aroma Technology, Shanghai Institute of Technology, 100 Haiquan Road, Shanghai, 201418, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Zhang
authors.affiliation: School of Perfume and Aroma Technology, Shanghai Institute of Technology, 100 Haiquan Road, Shanghai, 201418, China.
authors.forename: Qiujun
authors.initials: Q
authors.lastname: Peng
authors.affiliation: Shanghai Research Institute of Fragrance and Flavor Industry, 480 Nanning Road, Shanghai, 200232, China.
authors.forename: Lanting
authors.identifier: http://orcid.org/0000-0001-8467-3648
authors.initials: L
authors.lastname: Xu
authors.affiliation: Shanghai Research Institute of Fragrance and Flavor Industry, 480 Nanning Road, Shanghai, 200232, China.
authors.forename: Xianhua
authors.initials: X
authors.lastname: Pan
keywords: C−H activation; indazoles; olefination; regioselectivity; rhodium