title: Reoperation Rates After Long Posterior Spinal Fusion: Use of Recombinant Bone Morphogenetic Protein in Idiopathic and Non-idiopathic Scoliosis.
abstract: Bone morphogenetic protein (BMP) can increase the likelihood of solid arthrodesis in spinal surgery. This would imply fewer reoperations for pseudarthrosis, but small cohort sizes are inadequate to monitor these events. We sought to examine adolescent idiopathic (AIS) and non-idiopathic scoliosis (NIS) for reoperation events with and without the use of BMP using a large statewide database.
  
  
  
  The 2008-2011 New York State Inpatient Database was queried using International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes. Patients age 10 and older with a diagnosis of scoliosis and an index fusion of greater than 2 spinal motion segments were included. Patient identifiers and linkage variables were used to identify revisits. The relative risk of reoperation was calculated. The use of BMP at the initial inpatient stay was used to define the two cohorts for relative risk assessment.
  
  
  
  A total of 2,658 and 2,431 cases were identified of AIS and NIS, respectively. The use of BMP at the initial visit was performed at a rate of 4.5% for AIS and 21.0% for NIS fusion surgery. For posterior fusion cases longer than eight levels, the reoperation rate for pseudarthrosis was 1.0% in AIS and 18.4% in NIS (p < .001). For NIS fusions greater than eight levels, the rate of reoperation for pseudarthrosis after using BMP at the index surgery was 5% and 22% when BMP was not used, a relative risk of 4.0 (p < .001). For AIS, there was no substantial increase in risk when not using BMP for fusion greater than eight levels (p < .001).
  
  
  
  We found a significant decrease in the risk of reoperation for pseudarthrosis after long fusions when using BMP in the case of NIS. In contrast, use of BMP does not benefit the AIS population.
authors.affiliation: Department of Orthopaedic Surgery, New York University Hospital for Joint Diseases, 301 E 17th Street, New York, NY 10003, USA.
authors.forename: Justin C
authors.initials: JC
authors.lastname: Paul
authors.affiliation: Department of Orthopaedic Surgery, Mount Sinai Beth Israel, 820 2nd Ave. #7A, New York, NY 10017, USA. Electronic address: blonner@nyc.rr.com.
authors.forename: Baron S
authors.initials: BS
authors.lastname: Lonner
authors.affiliation: Department of Orthopaedic Surgery, New York University Hospital for Joint Diseases, 301 E 17th Street, New York, NY 10003, USA.
authors.forename: Shaleen
authors.initials: S
authors.lastname: Vira
authors.affiliation: Department of Orthopaedic Surgery, New York University Hospital for Joint Diseases, 301 E 17th Street, New York, NY 10003, USA.
authors.forename: Ian David
authors.initials: ID
authors.lastname: Kaye
authors.affiliation: Department of Orthopaedic Surgery, New York University Hospital for Joint Diseases, 301 E 17th Street, New York, NY 10003, USA.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Errico
mesh_terms: D000293:Adolescent; D019485:Bone Morphogenetic Proteins / Q000627:therapeutic use*; D002648:Child; D006801:Humans; D009518:New York; D012086:Reoperation; D012600:Scoliosis / Q000601:surgery*; D013123:Spinal Fusion / Q000379:methods*
chemical_list: D019485:Bone Morphogenetic Proteins
keywords: Adolescent idiopathic scoliosis; Bone morphogenetic protein; Non-idiopathic scoliosis