title: Autophagy in UV Damage Response.
abstract: UV radiation exposure from sunlight and artificial tanning beds is the major risk factor for the development of skin cancer and skin photoaging. UV-induced skin damage can trigger a cascade of DNA damage response signaling pathways, including cell cycle arrest, DNA repair and, if damage is irreparable, apoptosis. Compensatory proliferation replaces the apoptotic cells to maintain skin barrier integrity. Disruption of these processes can be exploited to promote carcinogenesis by allowing the survival and proliferation of damaged cells. UV radiation also induces autophagy, a catabolic process that clears unwanted or damaged proteins, lipids and organelles. The mechanisms by which autophagy is activated following UV exposure, and the functions of autophagy in UV response, are only now being clarified. Here, we summarize the current understanding of the mechanisms governing autophagy regulation by UV, the roles of autophagy in regulating cellular response to UV-induced photodamage and the implications of autophagy modulation in the treatment and prevention of photoaging and skin cancer.
authors.affiliation: Department of Medicine, Section of Dermatology, University of Chicago, Chicago, IL.|Committee on Cancer Biology, University of Chicago, Chicago, IL.
authors.forename: Ashley
authors.initials: A
authors.lastname: Sample
authors.affiliation: Department of Medicine, Section of Dermatology, University of Chicago, Chicago, IL.|Committee on Cancer Biology, University of Chicago, Chicago, IL.
authors.forename: Yu-Ying
authors.initials: YY
authors.lastname: He
mesh_terms: D017209:Apoptosis / Q000502:physiology; D001343:Autophagy / Q000528:radiation effects*; D049109:Cell Proliferation / Q000502:physiology; D002470:Cell Survival / Q000502:physiology; D004249:DNA Damage; D006801:Humans; D009381:Neoplasms, Radiation-Induced / Q000209:etiology* / Q000473:pathology; D018384:Oxidative Stress; D012867:Skin / Q000378:metabolism / Q000528:radiation effects*; D015595:Skin Aging / Q000528:radiation effects; D012878:Skin Neoplasms / Q000209:etiology* / Q000473:pathology; D013472:Sunlight / Q000009:adverse effects; D014466:Ultraviolet Rays / Q000009:adverse effects*