title: Developments in multiple breath washout testing in children with cystic fibrosis.
abstract: Lung clearance index (LCI) is becoming recognized as an important addition in the monitoring of pediatric cystic fibrosis (CF). The non-invasive technique is easy to perform in all ages, reproducible and increasingly being used in clinical trials. There is interest in utilizing it within the clinic setting but its current use is mostly as a research tool. The procedure is highly dependent on skilled operators and a relaxed testing environment is key to obtaining good quality measurements.
  
  
  
  Standardization of LCI is part of an ongoing collaborative, multicenter process. This review describes the background to LCI, discusses technical issues and limitations and provides examples of its utility in clinical and research contexts.
authors.affiliation: a NHLI, Imperial College London , UK.|b Royal Brompton and Harefield NHS Foundation Trust , London , UK.
authors.forename: Clare
authors.initials: C
authors.lastname: Saunders
authors.affiliation: a NHLI, Imperial College London , UK.|b Royal Brompton and Harefield NHS Foundation Trust , London , UK.
authors.forename: Katie
authors.initials: K
authors.lastname: Bayfield
authors.affiliation: a NHLI, Imperial College London , UK.|b Royal Brompton and Harefield NHS Foundation Trust , London , UK.
authors.forename: Samantha
authors.initials: S
authors.lastname: Irving
authors.affiliation: a NHLI, Imperial College London , UK.|b Royal Brompton and Harefield NHS Foundation Trust , London , UK.
authors.forename: Christopher
authors.initials: C
authors.lastname: Short
authors.affiliation: a NHLI, Imperial College London , UK.|b Royal Brompton and Harefield NHS Foundation Trust , London , UK.
authors.forename: Andrew
authors.initials: A
authors.lastname: Bush
authors.affiliation: a NHLI, Imperial College London , UK.|b Royal Brompton and Harefield NHS Foundation Trust , London , UK.
authors.forename: Jane C
authors.initials: JC
authors.lastname: Davies
mesh_terms: D002648:Child; D003550:Cystic Fibrosis / Q000175:diagnosis*; D006801:Humans; D012129:Respiratory Function Tests / Q000379:methods / Q000639:trends
keywords: Child; cystic fibrosis; lung clearance index; multiple breath washout; spirometry