title: The correlation between lymphocyte/monocyte ratio and coronary collateral circulation in stable coronary artery disease patients.
abstract: OBJECTIVE
  Coronary collateral circulation (CCC) has an important impact on cardiovascular prognosis and well-developed CCC is associated with better clinical outcomes. We investigated whether lymphocyte/monocyte ratio (LMR) has an association with CCC in patients with stable coronary artery disease (SCAD).
  
  
  METHODS
  The study population consisted of 245 patients with SCAD. Patients were classified into a poor CCC group (Rentrop grades 0/1, n = 87), or good CCC group (Rentrop grades 2/3, n = 158).
  
  
  RESULTS
  LMR values were significantly higher in patients with good CCC than in those with poor CCC (4.41 ± 1.58 vs 2.76 ± 1.10; p < 0.001). In receiver operating characteristic analysis, optimal cutoff of LMR for predicting well-developed CCC was 3.38. In multivariate analysis, LMR >3.38 (OR 4.637; p = 0.004), high sensitivity C-reactive protein (OR 0.810, p < 0.001), dyslipidemia (OR 2.485; p = 0.039), and presence of chronic total occlusion (OR 16.836; p < 0.001) were independent predictors of well-developed CCC.
  
  
  CONCLUSIONS
  Increased LMR predicts well-developed CCC in SCAD patients.
authors.affiliation: Department of Cardiology, Ankara Education & Research Hospital, Ankara, Turkey.
authors.forename: Alparslan
authors.initials: A
authors.lastname: Kurtul
authors.affiliation: Department of Cardiology, Ankara Education & Research Hospital, Ankara, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Duran
mesh_terms: D000368:Aged; D019540:Area Under Curve; D015415:Biomarkers / Q000032:analysis; D002097:C-Reactive Protein / Q000032:analysis; D003097:Collateral Circulation / Q000502:physiology*; D003324:Coronary Artery Disease / Q000150:complications / Q000175:diagnosis*; D050171:Dyslipidemias / Q000150:complications; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000166:cytology*; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000166:cytology*; D015999:Multivariate Analysis; D012372:ROC Curve
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein
keywords: coronary atherosclerosis; coronary collateral circulation; inflammation; lymphocyte; lymphocyte/monocyte ratio; monocyte; stable coronary artery disease