title: The long-term effect of oral isotretinoin therapy on macula ganglion cell complex thickness.
abstract: OBJECTIVE
  To evaluate the long-term effect of oral isotretinoin therapy on macula ganglion cell complex (GCC) thickness by spectral domain optical coherence tomography (SD-OCT).
  
  
  METHODS
  Newly diagnosed cystic acne patients who received low dose for a long time systemic isotretinoin therapy were included in this study. Thorough ophthalmic evaluation and GCC thickness analysis by using SD-OCT were performed at baseline, and at 1, 3, 6, and 12 months of treatment.
  
  
  RESULTS
  Forty-eight eyes of 24 patients (15 females, 9 males) were included in the study. The mean age of patients was 19.37 ± 2.74 years (range 14-25 years). The full ophthalmologic examination was normal in all eyes before treatment. During the treatment there were no change in visual acuity, refractive error, intraocular pressure and tear break-up time. The mean GCC thicknesses were 81.45 ± 4.91, 81.45 ± 5.12, 81.81 ± 4.68, 81.87 ± 4.91 and 81.64 ± 5.09 μm at pretreatment and at 1, 3, 6, and 12 months of treatment, respectively (p = 0.803).
  
  
  CONCLUSIONS
  One-year systemic use of isotretinoin had no significant effect on the thickness of macula ganglion cell. Macular ganglion cell analysis is useful for determining and following the toxic effects of systemic drugs on the retina. However, it is more rational to consider it as an adjunct to electrophysiological testing rather than used alone.
authors.affiliation: a Eye Department, Saglik Bakanligi Ankara Egitim ve Arastirma Hastanesi , Ankara , Turkey.
authors.forename: Gülizar
authors.initials: G
authors.lastname: Demirok
authors.affiliation: b Eye Department , Ufuk Universitesi Tip Fakultesi , Ankara , Turkey , and.
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Topalak
authors.affiliation: c Dermatology Department , Ufuk Universitesi Tip Fakultesi , Ankara , Turkey.
authors.forename: Özge
authors.initials: Ö
authors.lastname: Gündüz
authors.affiliation: c Dermatology Department , Ufuk Universitesi Tip Fakultesi , Ankara , Turkey.
authors.forename: Dilsun
authors.initials: D
authors.lastname: Yildirim
authors.affiliation: b Eye Department , Ufuk Universitesi Tip Fakultesi , Ankara , Turkey , and.
authors.forename: Mehmet Fatih
authors.initials: MF
authors.lastname: Kocamaz
authors.affiliation: b Eye Department , Ufuk Universitesi Tip Fakultesi , Ankara , Turkey , and.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Şengün
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy; D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D003879:Dermatologic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D015474:Isotretinoin / Q000494:pharmacology* / Q000627:therapeutic use; D008266:Macula Lutea / Q000166:cytology / Q000187:drug effects; D008297:Male; D012165:Retinal Ganglion Cells / Q000166:cytology / Q000187:drug effects*; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000187:drug effects; D055815:Young Adult
chemical_list: D003879:Dermatologic Agents; D015474:Isotretinoin
keywords: Ganglion cell complex layer; macular ganglion cell analysis; optical coherence tomography; retinal toxicity; systemic isotretinoin therapy