title: Effects of hydrophilic extract ofNasturtium officinaleon prevention of ethylene glycol induced renal stone in male Wistar rats.
abstract: BACKGROUND
  Nasturtium officinaleis a traditional herb that is used for diuresis.
  
  
  OBJECTIVE
  The aim of this study is to determine the effects of hydrophilic extract ofNasturtium officinaleon ethylene glycol-induced renal stone in male Wistar rats.
  
  
  METHODS
  In this study 32 male Wistar rats were randomly divided in six groups and studied during 30 days. Two groups of negative and healthy control received 1% ethylene glycol in water respectively. Low and high dose preventive groups, in addition to 1% ethylene glycol, daily gavaged with 750 mg/kg and 1.5 g/kg of extract respectively. All rats were hold in metabolic cages individually in days 0, 15 and 30 and 24-hour urine samples were collected and checked for urinary parameters of stone formation. In 30th day, rats were anesthetized with ether, and after taking serum sample from them, were sacrificed and their kidneys were sent for pathological evaluation and for presence and volume of calcium oxalate crystals.
  
  
  RESULTS
  Percentage of calcium oxalate crystals in negative control groups (75%), preventive groups with low dose (28.6%) and high dose (57.1%) in comparison to healthy control group (12.5%) increased (P< 0.05). In 30th day urinary oxalate concentration in preventive and negative control groups were more than healthy control group (P< 0.05).
  
  
  CONCLUSIONS
  This research showed that theNasturtium officinaleextract has no significant effects in urinary and chemical parameters efficient in calcium oxalate stone crystals in rat but its extract in low dose has some preventive effect on renal stone formation.
authors.affiliation: Medicinal Plant Research center, Yasuj University of Medical Sciences, Yasuj, Iran.
authors.forename: Sadrollah
authors.initials: S
authors.lastname: Mehrabi
authors.affiliation: Student Research Committee, Yasuj University of Medical Sciences, Yasuj, Iran.
authors.forename: Eslam
authors.initials: E
authors.lastname: Askarpour
authors.affiliation: Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Farhad
authors.initials: F
authors.lastname: Mehrabi
authors.affiliation: Medicinal Plant Research center, Yasuj University of Medical Sciences, Yasuj, Iran.
authors.forename: Ramin
authors.initials: R
authors.lastname: Jannesar
keywords: Calcium oxalate; Ethylene glycol; Nasturtium officinale; Nephrolithiasis