title: The Anticancer Potential of Ionic Liquids.
abstract: Among the many challenges that the pharmaceutical industry currently faces is the need to develop innovative and effective therapies. The investigation of alternative and effective therapies against cancer is a current goal of the pharmaceutical industry. Ionic liquids (ILs) have emerged recently as a topic of study by researchers in the pharmaceutical industry in their search for new therapeutic agents. By definition, ILs are organic salts with melting points below 100 °C that are composed only by ions. Their main advantage lies in the numerous possible combinations of cations and anions, which allow adjustments in their physicochemical properties. The combination between ILs and active pharmaceutical ingredients (APIs) may improve the properties of APIs. In addition, the antitumor properties of these compounds have been described. Several studies have reported the use of ILs in biomedical applications as therapeutic agents, namely as antitumor agents. This review describes the recent proposed applications of ILs as antitumor agents.
authors.affiliation: Ciências Químicas e das Biomoléculas / Centro de Investigação em Saúde e Ambiente (CISA), ESS-Escola Superior de Saúde do Porto do Instituto Politécnico do Porto, Portugal, Rua Dr. António Bernardino de Almeida, 400, 4200-072, Porto, Portugal.
authors.forename: Ana Rita
authors.initials: AR
authors.lastname: Dias
authors.affiliation: Laboratório de Farmacologia e Biocompatibilidade Celular, Faculdade de Medicina Dentária, Universidade do Porto, Rua Dr. Manuel Pereira da Silva, 4200-393, Porto, Portugal.|ESS-Escola Superior de Saúde do Porto do Instituto Politécnico do Porto, (Portugal).|Instituto Politécnico de Viana do Castelo, Escola Superior de Saúde, Portugal.
authors.forename: João
authors.identifier: 0000-0003-1375-8067
authors.initials: J
authors.lastname: Costa-Rodrigues
authors.affiliation: Laboratório de Farmacologia e Biocompatibilidade Celular, Faculdade de Medicina Dentária, Universidade do Porto, Rua Dr. Manuel Pereira da Silva, 4200-393, Porto, Portugal.
authors.forename: Maria Helena
authors.initials: MH
authors.lastname: Fernandes
authors.affiliation: Ciências Químicas e das Biomoléculas / Centro de Investigação em Saúde e Ambiente (CISA), ESS-Escola Superior de Saúde do Porto do Instituto Politécnico do Porto, Portugal, Rua Dr. António Bernardino de Almeida, 400, 4200-072, Porto, Portugal.|UCIBIO-REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências da Universidade do Porto, Rua do Campo Alegre 687, 4169-007, Porto, Portugal.
authors.forename: Ricardo
authors.identifier: 0000-0002-1761-117X
authors.initials: R
authors.lastname: Ferraz
authors.affiliation: Ciências Químicas e das Biomoléculas / Centro de Investigação em Saúde e Ambiente (CISA), ESS-Escola Superior de Saúde do Porto do Instituto Politécnico do Porto, Portugal, Rua Dr. António Bernardino de Almeida, 400, 4200-072, Porto, Portugal.|I3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen, 208, 4200-135, Porto, Portugal.
authors.forename: Cristina
authors.identifier: 0000-0002-9920-936X
authors.initials: C
authors.lastname: Prudêncio
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D052578:Ionic Liquids / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents; D052578:Ionic Liquids
keywords: active pharmaceutical ingredients; antitumor agents; cancer; ionic liquids; toxicity