title: Examining Topological Domain Influence on Enhancer Function.
abstract: Enhancers regulate the expression of target genes across large genomic distances, but it is unclear how recently discovered topological domains affect this regulation. Reporting in this issue of Developmental Cell, Symmons et al. (2016) show that the endogenous Shh topological domain promotes functional interactions between Shh and its remote enhancer.
authors.affiliation: Epigenetic Regulation and Chromatin Architecture Group, Berlin Institute for Medical Systems Biology, Max-Delbrück Centre for Molecular Medicine, Robert-Rössle Strasse, Berlin-Buch 13092, Germany. Electronic address: robert.beagrie@mdc-berlin.de.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Beagrie
authors.affiliation: Epigenetic Regulation and Chromatin Architecture Group, Berlin Institute for Medical Systems Biology, Max-Delbrück Centre for Molecular Medicine, Robert-Rössle Strasse, Berlin-Buch 13092, Germany. Electronic address: ana.pombo@mdc-berlin.de.
authors.forename: Ana
authors.initials: A
authors.lastname: Pombo
mesh_terms: D004742:Enhancer Elements, Genetic; D018507:Gene Expression Regulation, Developmental