title: Importance of diagnostic work-up of Guillain-Barré syndrome in pregnancy.
abstract: We report a full-term neonate presenting with symptomatic congenital cytomegalovirus (CMV) infection with hepatosplenomegaly, 'blueberry muffin' rash, intracranial calcifications, thrombocytopenia and respiratory distress. Maternal history was relevant for Guillain-Barré syndrome (GBS) during the first trimester of pregnancy. CMV infection is an important cause of GBS; thus, women presenting GBS during pregnancy should be screened for CMV infection. If positive, they may benefit from specialised monitoring and treatment in the antenatal period, which may decrease the risk of major neurodevelopmental sequelae of congenital CMV in the neonate.
authors.affiliation: Department of Pediatrics, State University of New York Downstate Medical Center, Brooklyn, New York, USA.
authors.forename: Elza
authors.initials: E
authors.lastname: Pollak-Christian
authors.affiliation: Department of Neonatology, The Hospital for Sick Children, Toronto, Ontario, Canada.|University of Toronto, Toronto, Ontario, Canada.
authors.forename: Kyong-Soon
authors.initials: KS
authors.lastname: Lee
mesh_terms: D000328:Adult; D000667:Ampicillin / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002657:Child Development; D003586:Cytomegalovirus Infections / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology / Q000821:virology; D003638:Deafness; D005076:Exanthema / Q000473:pathology; D005260:Female; D005334:Fever; D020275:Guillain-Barre Syndrome / Q000150:complications / Q000175:diagnosis* / Q000821:virology*; D006529:Hepatomegaly / Q000175:diagnosis / Q000821:virology*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D065886:Neurodevelopmental Disorders; D017713:Platelet Transfusion; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis* / Q000503:physiopathology / Q000821:virology*; D012127:Respiratory Distress Syndrome, Newborn / Q000150:complications / Q000821:virology*; D013163:Splenomegaly / Q000175:diagnosis / Q000821:virology*; D013921:Thrombocytopenia; D014031:Tobramycin / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D000667:Ampicillin; D014031:Tobramycin