title: A one carbon staple for orthogonal copper-catalyzed azide-alkyne cycloadditions.
abstract: We describe herein the use of α-hydroxy-β-azidotetrazoles, easily prepared in one step from α,β-epoxynitriles, as new scaffolds for orthogonal CuAAC reactions performed on the same carbon atom. After a first ligation involving an alkyne with the β-azido moiety, treatment with EDC smoothly releases an alkyne from the remaining α-hydroxytetrazole, ready for a second CuAAC reaction. This "double click" process can be performed iteratively, leading to triazolamers.
authors.affiliation: Institut Lavoisier de Versailles, UMR 8180, Université de Versailles St-Quentin-en-Yvelines, Université Paris-Saclay. 45, av. des Etats-Unis, 78035 Versailles Cedex, France. francois.couty@uvsq.fr karen.wright@uvsq.fr.
authors.forename: Karen
authors.initials: K
authors.lastname: Wright
authors.affiliation: Institut Lavoisier de Versailles, UMR 8180, Université de Versailles St-Quentin-en-Yvelines, Université Paris-Saclay. 45, av. des Etats-Unis, 78035 Versailles Cedex, France. francois.couty@uvsq.fr karen.wright@uvsq.fr.
authors.forename: Pierre
authors.initials: P
authors.lastname: Quinodoz
authors.affiliation: Institut Lavoisier de Versailles, UMR 8180, Université de Versailles St-Quentin-en-Yvelines, Université Paris-Saclay. 45, av. des Etats-Unis, 78035 Versailles Cedex, France. francois.couty@uvsq.fr karen.wright@uvsq.fr.
authors.forename: Bruno
authors.initials: B
authors.lastname: Drouillat
authors.affiliation: Institut Lavoisier de Versailles, UMR 8180, Université de Versailles St-Quentin-en-Yvelines, Université Paris-Saclay. 45, av. des Etats-Unis, 78035 Versailles Cedex, France. francois.couty@uvsq.fr karen.wright@uvsq.fr.
authors.forename: François
authors.initials: F
authors.lastname: Couty