title: Biocompatible Polymer Nanoformulation To Improve the Release and Safety of a Drug Mimic Molecule Detectable via ICP-MS.
abstract: Fluorescent poly(ε-caprolactone)-based nanoparticles (NPs) have been synthesized and successfully loaded with a titanium organometallic compound as a mimic of a water-insoluble drug. The nature of this nanovector enabled us to combine the quantification of the metal in tissues after systemic administration in healthy immunocompetent mice by inductively coupled plasma mass spectroscopy (ICP-MS) followed by the visualization of NPs in organ sections by confocal microscopy. This innovative method of nanodrug screening has enabled us to elucidate the crucial parameters of their kinetics. The organometallic compound is a good mimic of most anticancer drugs, and this approach is an interesting starting point to design the relevance of a broad range of nanoformulations in terms of safety and targeted delivery of the cargoes.
authors.affiliation: Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zurich , Vladimir-Prelog-Weg 1, 8093 Zurich, Switzerland.
authors.forename: Raffaele
authors.initials: R
authors.lastname: Ferrari
authors.affiliation: Department of Molecular Biochemistry and Pharmacology, IRCCS - Istituto di Ricerche Farmacologiche Mario Negri , Via La Masa 19, 20156 Milan, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Talamini
authors.affiliation: Department of Molecular Biochemistry and Pharmacology, IRCCS - Istituto di Ricerche Farmacologiche Mario Negri , Via La Masa 19, 20156 Milan, Italy.
authors.forename: Martina Bruna
authors.initials: MB
authors.lastname: Violatto
authors.affiliation: Department of Molecular Biochemistry and Pharmacology, IRCCS - Istituto di Ricerche Farmacologiche Mario Negri , Via La Masa 19, 20156 Milan, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Giangregorio
authors.affiliation: Department of Chemistry, Materials and Chemical Engineering, Politecnico di Milano , Via Mancinelli 7, 20131 Milan, Italy.
authors.forename: Mattia
authors.initials: M
authors.lastname: Sponchioni
authors.affiliation: Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zurich , Vladimir-Prelog-Weg 1, 8093 Zurich, Switzerland.
authors.forename: Massimo
authors.initials: M
authors.lastname: Morbidelli
authors.affiliation: Department of Molecular Biochemistry and Pharmacology, IRCCS - Istituto di Ricerche Farmacologiche Mario Negri , Via La Masa 19, 20156 Milan, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Salmona
authors.affiliation: Department of Molecular Biochemistry and Pharmacology, IRCCS - Istituto di Ricerche Farmacologiche Mario Negri , Via La Masa 19, 20156 Milan, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Bigini
authors.affiliation: Department of Chemistry, Materials and Chemical Engineering, Politecnico di Milano , Via Mancinelli 7, 20131 Milan, Italy.
authors.forename: Davide
authors.identifier: 0000-0003-2759-9781
authors.initials: D
authors.lastname: Moscatelli
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical / Q000379:methods; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods; D008297:Male; D051379:Mice; D046529:Microscopy, Electron, Transmission / Q000379:methods; D053758:Nanoparticles / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry; D011091:Polyesters / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D014025:Titanium / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D001672:Biocompatible Materials; D004337:Drug Carriers; D009942:Organometallic Compounds; D011091:Polyesters; D011108:Polymers; C016240:polycaprolactone; D014025:Titanium
keywords: ICP-MS; biodistribution; drug delivery; drug development; nanoparticle; titanium