title: Extra-tongue oral granular cell tumor: Histological and immunohistochemical aspect.
abstract: BACKGROUND
  Granular cell tumor (GCT) is an uncommon benign tumor founded in any part of the body but mainly in the tongue. Extra-tongue oral granular cell tumor (ETOGCT) is rare with few cases reported. Here we describe seven cases of oral GCT located in sites other then the tongue and discuss histopathological and immunohistochemical differences between differential diagnoses.
  
  
  METHODS
  We retrieved all cases diagnosed with oral granular cell tumor, from the Oral Pathology Service at the School of Dentistry/ University of São Paulo, and excluded the ones sited in the tongue. Immunohistochemical staining anti-S100 was also performed.
  
  
  RESULTS
  The presented cases of Extra-tongue Oral Granular Cell Tumor (ETOGT) are composed by granular cells with intimately association with the adjacent tissue. Atypia and mitoses were not seen, and in most cases, the typical pseudoepitheliomatous hyperplasia was not observed.
  
  
  CONCLUSIONS
  The importance of an adequate attention is to avoid misdiagnoses, since ETOGT is rare and the tricking histopathological findings could induce to it. All the cases can be differentiated from the tumors that has a granular cell proliferation through a morphological analysis and when needed, immunohistochemistry stain.
authors.affiliation: Av. Professor Lineu Prestes, 2227, Cidade Universitária, 05508-000- São Paulo, SP, Brazil, pritobouti@usp.br.
authors.forename: P-L
authors.initials: PL
authors.lastname: Tobouti
authors.forename: F-M
authors.initials: FM
authors.lastname: Pigatti
authors.forename: M-C
authors.initials: MC
authors.lastname: Martins-Mussi
authors.forename: B-T
authors.initials: BT
authors.lastname: Sedassari
authors.forename: S-C
authors.initials: SC
authors.lastname: Orsini-Machado de Sousa
mesh_terms: D000328:Adult; D005260:Female; D016586:Granular Cell Tumor / Q000276:immunology* / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000276:immunology* / Q000473:pathology*