title: Ang-2 but not Ang-1 expression in perivascular soft tissue tumors.
abstract: Perivascular soft tissue tumors are relatively uncommon neoplasms of unclear line of differentiation, although most are presumed to originate from pericytes. Previously, we reported a shared immunophenotype across these related tumor types. Here, we extend these findings to examine the expression of the pericyte markers angiopoietin-1 and -2 (Ang-1 and -2) among perivascular soft tissue tumors. Results showed consistent Ang-2 but not Ang-1 expression across tumor types. In summary, the absence of Ang-1 expression distinguishes perivascular from vascular soft tissue tumors. Ang-2 expression is present across perivascular soft tissue tumors, with some variation between histologic subtypes.
authors.affiliation: School of Dentistry, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
authors.forename: Swati
authors.initials: S
authors.lastname: Shrestha
authors.affiliation: School of Dentistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
authors.forename: Jia
authors.initials: J
authors.lastname: Shen
authors.affiliation: Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
authors.forename: Paulina
authors.initials: P
authors.lastname: Giacomelli
authors.affiliation: Nationwide Children's Hospital, Columbus, OH 43205, USA.
authors.forename: Michelle A
authors.initials: MA
authors.lastname: Scott
authors.affiliation: Orthopedic Hospital Research Center, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Surgery, University of California, Los Angeles, Los Angeles, CA 90095, USA.
authors.forename: Chia
authors.initials: C
authors.lastname: Soo
authors.affiliation: School of Dentistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
authors.forename: Kang
authors.initials: K
authors.lastname: Ting
authors.affiliation: Orthopedic Hospital Research Center, University of California, Los Angeles, Los Angeles, CA 90095, USA; Center for Regenerative Medicine, University of Edinburgh, Edinburgh EH8 9JT, UK.
authors.forename: Bruno
authors.initials: B
authors.lastname: Péault
authors.affiliation: Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
authors.forename: Sarah M
authors.initials: SM
authors.lastname: Dry
authors.affiliation: School of Dentistry, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Orthopedic Hospital Research Center, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Pathology, Johns Hopkins University, Baltimore, MD 21279, USA.
authors.forename: Aaron W
authors.initials: AW
authors.lastname: James
keywords: Angioleiomyoma; Angiopoietin; Glomus tumor; Myopericytoma; Pericyte