title: Influence of Implant Surface Texture Design on Peri-Acetabular Bone Ingrowth: A Mechanobiology Based Finite Element Analysis.
abstract: The fixation of uncemented acetabular components largely depends on the amount of bone ingrowth, which is influenced by the design of the implant surface texture. The objective of this numerical study is to evaluate the effect of these implant texture design factors on bone ingrowth around an acetabular component. The novelty of this study lies in comparative finite element (FE) analysis of 3D microscale models of the implant-bone interface, considering patient-specific mechanical environment, host bone material property and implant-bone relative displacement, in combination with sequential mechanoregulatory algorithm and design of experiment (DOE) based statistical framework. Results indicated that the bone ingrowth process was inhibited due to an increase in interbead spacing from 200 μm to 600 μm and bead diameter from 1000 μm to 1500 μm and a reduction in bead height from 900 μm to 600 μm. Bead height, a main effect, was found to have a predominant influence on bone ingrowth. Among the interaction effects, the combination of bead height and bead diameter was found to have a pronounced influence on bone ingrowth process. A combination of low interbead spacing (P = 200 μm), low bead diameter (D = 1000 μm), and high bead height (H = 900 μm) facilitated peri-acetabular bone ingrowth and an increase in average Young's modulus of newly formed tissue layer. Hence, such a surface texture design seemed to provide improved fixation of the acetabular component.
authors.affiliation: Department of Mechanical Engineering, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal 721 302, India.
authors.forename: Kaushik
authors.initials: K
authors.lastname: Mukherjee
authors.affiliation: Professor Department of Mechanical Engineering, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal 721 302, India e-mail: sangupta@mech.iitkgp.ernet.in.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Gupta
mesh_terms: D000077:Acetabulum / Q000254:growth & development* / Q000601:surgery; D001696:Biomechanical Phenomena; D020342:Finite Element Analysis; D055595:Mechanical Phenomena; D008954:Models, Biological; D019736:Prostheses and Implants; D011474:Prosthesis Design; D013499:Surface Properties