title: Impact of Pre-Pregnancy BMI on B Vitamin and Inflammatory Status in Early Pregnancy: An Observational Cohort Study.
abstract: Maternal nutrition and inflammation have been suggested as mediators in the development of various adverse pregnancy outcomes associated with maternal obesity. We have investigated the relation between pre-pregnancy BMI, B vitamin status, and inflammatory markers in a group of healthy pregnant women. Cobalamin, folate, pyridoxal 5'-phosphate, and riboflavin; and the metabolic markers homocysteine, methylmalonic acid, and 3-hydroxykynurenine/xanthurenic acid ratio (HK/XA); and markers of cellular inflammation, neopterin and kynurenine/tryptophan ratio (KTR) were determined in pregnancy week 18 and related to pre-pregnancy body mass index (BMI), in 2797 women from the Norwegian Mother and Child Cohort Study (MoBa). Pre-pregnancy BMI was inversely related to folate, cobalamin, pyridoxal 5'-phosphate (PLP), and riboflavin (p< 0.001), and associated with increased neopterin and KTR levels (p< 0.001). Inflammation seemed to be an independent predictor of low vitamin B6 status, as verified by low PLP and high HK/XA ratio. A high pre-pregnancy BMI is a risk factor for low B vitamin status and increased cellular inflammation. As an optimal micronutrient status is vital for normal fetal development, the observed lower B vitamin levels may contribute to adverse pregnancy outcomes associated with maternal obesity and B vitamin status should be assessed in women with high BMI before they get pregnant.
authors.affiliation: Laboratory of Clinical Biochemistry, Haukeland University Hospital, 5021 Bergen, Norway. almo@helse-bergen.no.
authors.forename: Anne-Lise
authors.initials: AL
authors.lastname: Bjørke-Monsen
authors.affiliation: Bevital AS, 5021 Bergen, Norway. Arve.Ulvik@uib.no.
authors.forename: Arve
authors.initials: A
authors.lastname: Ulvik
authors.affiliation: Centre for Clinical Research, Haukeland University Hospital, 5021 Bergen, Norway. Roy.Nilsen@uib.no.
authors.forename: Roy M
authors.initials: RM
authors.lastname: Nilsen
authors.affiliation: Bevital AS, 5021 Bergen, Norway. oivind.midttun@bevital.no.
authors.forename: Øivind
authors.initials: Ø
authors.lastname: Midttun
authors.affiliation: The Norwegian Institute of Public Health, 0403 Oslo, Norway. Christine.Roth@fhi.no.|Imprints Center for Genetic and Environmental Life Course Studies, Mailman School of Public Health and New York State Psychiatric Institute, Columbia University, New York, NY 10027, USA. Christine.Roth@fhi.no.
authors.forename: Christine
authors.initials: C
authors.lastname: Roth
authors.affiliation: The Norwegian Institute of Public Health, 0403 Oslo, Norway. Per.Magnus@fhi.no.
authors.forename: Per
authors.initials: P
authors.lastname: Magnus
authors.affiliation: The Norwegian Institute of Public Health, 0403 Oslo, Norway. camilla.stoltenberg@fhi.no.|Department of Public Health and Primary Health Care, University of Bergen, 5007 Bergen, Norway. camilla.stoltenberg@fhi.no.
authors.forename: Camilla
authors.initials: C
authors.lastname: Stoltenberg
authors.affiliation: The Norwegian Institute of Public Health, 0403 Oslo, Norway. SteinEmil.Vollset@fhi.no.|Department of Public Health and Primary Health Care, University of Bergen, 5007 Bergen, Norway. SteinEmil.Vollset@fhi.no.
authors.forename: Stein Emil
authors.initials: SE
authors.lastname: Vollset
authors.affiliation: The Norwegian Institute of Public Health, 0403 Oslo, Norway. Ted.Reichborn-Kjennerud@fhi.no.|Institute of Clinical Medicine, University of Oslo, 0313 Oslo, Norway. Ted.Reichborn-Kjennerud@fhi.no.
authors.forename: Ted
authors.initials: T
authors.lastname: Reichborn-Kjennerud
authors.affiliation: Laboratory of Clinical Biochemistry, Haukeland University Hospital, 5021 Bergen, Norway. per.ueland@ikb.uib.no.|Department of Clinical Science, University of Bergen, 5007 Bergen, Norway. per.ueland@ikb.uib.no.
authors.forename: Per Magne
authors.initials: PM
authors.lastname: Ueland
mesh_terms: D000328:Adult; D015992:Body Mass Index; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D039382:Maternal Nutritional Physiological Phenomena; D011247:Pregnancy; D014803:Vitamin B Complex / Q000097:blood*; D055815:Young Adult
chemical_list: D014803:Vitamin B Complex
keywords: B vitamins; inflammation; obesity; pre-pregnancy BMI; pregnancy