title: Aminofluorene-Mediated Biomimetic Domino Amination-Oxygenation of Aldehydes to Amides.
abstract: A conceptually novel biomimetic strategy based on a domino amination-oxygenation reaction was developed for direct amidation of aldehydes under metal-free conditions employing molecular oxygen as the oxidant. 9-Aminofluorene derivatives acted as pyridoxamine-5'-phosphate equivalents for efficient, chemoselective, and operationally simple amine-transfer oxygenation reaction. Unprecedented RNH transfer involving secondary amine to produce secondary amides was achieved. In the presence of18O2,18O-amide was formed with excellent (95%) isotopic purity.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Guwahati , Guwahati 781039, India.
authors.forename: Santanu
authors.initials: S
authors.lastname: Ghosh
authors.affiliation: Department of Chemistry, Indian Institute of Technology Guwahati , Guwahati 781039, India.
authors.forename: Chandan K
authors.initials: CK
authors.lastname: Jana