title: Haptotatic Plasma Polymerized Surfaces for Rapid Tissue Regeneration and Wound Healing.
abstract: Skin has a remarkable capacity for regeneration; however, with an ever aging population, there is a growing burden to the healthcare system from chronic wounds. Novel therapies are required to address the problems associated with nonhealing chronic wounds. Novel wound dressings that can encourage increased reepithelialization could help to reduce the burden of chronic wounds. A suite of chemically defined surfaces have been produced using plasma polymerization, and the ability of these surfaces to support the growth of primary human skin cells has been assessed. Additionally, the ability of these surfaces to modulate cell migration and morphology has also been investigated. Keratinocytes and endothelial cells were extremely sensitive to surface chemistry showing increased viability and migration with an increased number of carboxylic acid functional groups. Fibroblasts proved to be more tolerant to changes in surface chemistry; however, these cells migrated fastest over amine-functionalized surfaces. The novel combination of comprehensive chemical characterization coupled with the focus on cell migration provides a unique insight into how a material's physicochemical properties affect cell migration.
authors.affiliation: Wound Management Innovation Cooperative Research Centre , Brisbane 4059, Queensland, Australia.|Future Industries Institute, University of South Australia , Adelaide 5095, South Australia, Australia.
authors.forename: Louise E
authors.initials: LE
authors.lastname: Smith
authors.affiliation: Wound Management Innovation Cooperative Research Centre , Brisbane 4059, Queensland, Australia.
authors.forename: Christian
authors.initials: C
authors.lastname: Bryant
authors.affiliation: Future Industries Institute, University of South Australia , Adelaide 5095, South Australia, Australia.|School of Information Technology and Mathematical Sciences, University of South Australia , Adelaide, 5095, South Australia, Australia.
authors.forename: Marta
authors.initials: M
authors.lastname: Krasowska
authors.affiliation: Wound Management Innovation Cooperative Research Centre , Brisbane 4059, Queensland, Australia.|Future Industries Institute, University of South Australia , Adelaide 5095, South Australia, Australia.
authors.forename: Allison J
authors.initials: AJ
authors.lastname: Cowin
authors.affiliation: Wound Management Innovation Cooperative Research Centre , Brisbane 4059, Queensland, Australia.|School of Engineering, University of South Australia , Adelaide 5095, South Australia, Australia.
authors.forename: Jason D
authors.initials: JD
authors.lastname: Whittle
authors.affiliation: Kroto Research Institute, University of Sheffield , Sheffield S3 7HQ, South Yorkshire, United Kingdom.
authors.forename: Sheila
authors.initials: S
authors.lastname: MacNeil
authors.affiliation: Wound Management Innovation Cooperative Research Centre , Brisbane 4059, Queensland, Australia.|Future Industries Institute, University of South Australia , Adelaide 5095, South Australia, Australia.
authors.forename: Robert D
authors.initials: RD
authors.lastname: Short
mesh_terms: D000179:Acrylates / Q000737:chemistry / Q000494:pharmacology; D000475:Alkenes / Q000737:chemistry / Q000494:pharmacology; D002465:Cell Movement / Q000502:physiology; D002470:Cell Survival / Q000502:physiology; D002633:Chemotaxis; D020099:Coated Materials, Biocompatible / Q000737:chemistry* / Q000494:pharmacology*; D042783:Endothelial Cells / Q000166:cytology / Q000187:drug effects; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D006801:Humans; D015603:Keratinocytes / Q000166:cytology / Q000187:drug effects; D058629:Plasma Skin Regeneration / Q000379:methods*; D020005:Propanols / Q000737:chemistry / Q000494:pharmacology; D012867:Skin / Q000166:cytology / Q000187:drug effects; D013499:Surface Properties; D014945:Wound Healing / Q000502:physiology*; D014947:Wounds and Injuries / Q000473:pathology / Q000628:therapy*
chemical_list: D000179:Acrylates; D000475:Alkenes; D020099:Coated Materials, Biocompatible; D020005:Propanols; C006463:allyl alcohol; C036658:acrylic acid; C546881:1,7-octadiene
keywords: cell migration; haptotaxis; plasma polymerization; surface modification; wound healing