title: Dynapenia and Metabolic Health in Obese and Nonobese Adults Aged 70 Years and Older: The LIFE Study.
abstract: OBJECTIVE
  The purpose of this study was to examine the relationship between dynapenia and metabolic risk factors in obese and nonobese older adults.
  
  
  METHODS
  A total of 1453 men and women (age ≥70 years) from the Lifestyle Interventions and Independence for Elders (LIFE) Study were categorized as (1) nondynapenic/nonobese (NDYN-NO), (2) dynapenic/nonobese (DYN-NO), (3) nondynapenic/obese (NDYN-O), or (4) dynapenic/obese (DYN-O), based on muscle strength (Foundation for the National Institute of Health criteria) and body mass index. Dependent variables were blood lipids, fasting glucose, blood pressure, presence of at least 3 metabolic syndrome (MetS) criteria, and other chronic conditions.
  
  
  RESULTS
  A significantly higher likelihood of having abdominal obesity criteria in NDYN-NO compared with DYN-NO groups (55.6 vs 45.1%, P ≤ .01) was observed. Waist circumference also was significantly higher in obese groups (DYN-O = 114.0 ± 12.9 and NDYN-O = 111.2 ± 13.1) than in nonobese (NDYN-NO = 93.1 ± 10.7 and DYN-NO = 92.2 ± 11.2, P ≤ .01); and higher in NDYN-O compared with DYN-O (P = .008). Additionally, NDYN-O demonstrated higher diastolic blood pressure compared with DYN-O (70.9 ± 10.1 vs 67.7 ± 9.7, P ≤ .001). No significant differences were found across dynapenia and obesity status for all other metabolic components (P > .05). The odds of having MetS or its individual components were similar in obese and nonobese, combined or not with dynapenia (nonsignificant odds ratio [95% confidence interval]).
  
  
  CONCLUSIONS
  Nonobese dynapenic older adults had fewer metabolic disease risk factors than nonobese and nondynapenic older adults. Moreover, among obese older adults, dynapenia was associated with lower risk of meeting MetS criteria for waist circumference and diastolic blood pressure. Additionally, the presence of dynapenia did not increase cardiometabolic disease risk in either obese or nonobese older adults.
authors.affiliation: Department of Aging and Geriatric Research, University of Florida, Gainesville, FL; Department of Sciences of Physical Activity, Université du Québec à Montréal, CRIUGM, Montréal, Québec, Canada. Electronic address: aubertin.mylene@gmail.com.
authors.forename: Mylène
authors.initials: M
authors.lastname: Aubertin-Leheudre
authors.affiliation: Department of Aging and Geriatric Research, University of Florida, Gainesville, FL.
authors.forename: Stephen
authors.initials: S
authors.lastname: Anton
authors.affiliation: Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC.
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Beavers
authors.affiliation: Department of Aging and Geriatric Research, University of Florida, Gainesville, FL.
authors.forename: Todd M
authors.initials: TM
authors.lastname: Manini
authors.affiliation: Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA.
authors.forename: Roger
authors.initials: R
authors.lastname: Fielding
authors.affiliation: Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA.
authors.forename: Ann
authors.initials: A
authors.lastname: Newman
authors.affiliation: Preventive Medicine Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA.
authors.forename: Tim
authors.initials: T
authors.lastname: Church
authors.affiliation: Sticht Center on Aging, School of Medicine, Wake Forest University, Winston-Salem, NC.
authors.forename: Stephen B
authors.initials: SB
authors.lastname: Kritchevsky
authors.affiliation: Department of Kinesiology, Pennsylvania State University, University Park, PA.
authors.forename: David
authors.initials: D
authors.lastname: Conroy
authors.affiliation: Department of Internal Medicine, Northwestern Medical Faculty Foundation, Chicago, IL.
authors.forename: Mary M
authors.initials: MM
authors.lastname: McDermott
authors.affiliation: Institute of Gerontology, University of Michingan, Ann Arbor, MI.
authors.forename: Anda
authors.initials: A
authors.lastname: Botoseneanu
authors.affiliation: Stanford Prevention Research Center, Stanford University, Palo Alto, CA.
authors.forename: Michelle E
authors.initials: ME
authors.lastname: Hauser
authors.affiliation: Department of Aging and Geriatric Research, University of Florida, Gainesville, FL.
authors.forename: Marco
authors.initials: M
authors.lastname: Pahor
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000503:physiopathology*; D053580:Muscle Strength / Q000502:physiology*; D009765:Obesity / Q000503:physiopathology*; D012307:Risk Factors; D055105:Waist Circumference
keywords: Muscle strength; aging; metabolic syndrome; obesity