title: A population-based epidemiologic study of adult neuromuscular disease in the Republic of Ireland.
abstract: OBJECTIVE
  To estimate the prevalence rates (PRs) of acquired and inherited neuromuscular diseases (NMD) in the adult Irish population, reflecting the burden of these conditions in a single country.
  
  
  METHODS
  This population-based study was performed in the Republic of Ireland (RoI), with a PR estimated for December 2013. Multiple case ascertainment sources were utilized. Demographic and clinical information and relevant diagnostic results were registered.
  
  
  RESULTS
  A total of 2,641 adults were identified, giving a PR of 62.6/100,000 (95% confidence interval [CI] 59.95-65.24) for all NMD in RoI. Disease-specific PR include chronic inflammatory demyelinating polyradiculoneuropathy 5.87/100,000 (95% CI 5.06-6.68), Charcot-Marie-Tooth 10.52/100,000 (95% CI 9.44-11.61), hereditary neuropathy with liability to pressure palsies 0.84/100,000 (95% CI 0.54-1.15), myotonic dystrophy type I 6.75/100,000 (95% CI 5.88-7.61), Duchenne muscular dystrophy 3.0/100,000 (95% CI 2.33-3.70), Becker muscular dystrophy 2.2/100,000 (95% CI 1.64-2.88), facioscapulohumeral dystrophy 2.59/100,000 (95% CI 2.05-3.13), limb-girdle muscular dystrophy 2.88/100,000 (95% CI 2.31-3.45), periodic paralysis 1.72/100,000 (95% CI 1.28-2.15), myotonia congenita 0.32/100,000 (95% CI 0.18-0.56), paramyotonia congenita 0.15/100,000 (95% CI 0.06-0.34), Kennedy disease 0.83/100,000 (95% CI 0.40-1.27), Lambert-Eaton myasthenic syndrome 0.29/100,000 (95% CI 0.11-0.47), myasthenia gravis 15.12/100,000 (95% CI 13.82-16.42), and sporadic inclusion body myositis 11.7/100,000 (95% CI 9.82-13.58). PR for amyotrophic lateral sclerosis was established from an existing Register as 7.20/100,000 (95% CI 6.34-8.15).
  
  
  CONCLUSIONS
  The PR of all adult NMD in RoI is relatively high when compared with other chronic neurologic disorders, although some figures may be an underestimate of the true prevalence. The data provide a framework for international comparison and service planning.
authors.affiliation: From the Department of Neurology (S.L., A.M.R.), Cork University Hospital; and Department of Neurology (O.H.), Beaumont Hospital, Dublin, Ireland. stela_lefter@yahoo.com.
authors.forename: Stela
authors.initials: S
authors.lastname: Lefter
authors.affiliation: From the Department of Neurology (S.L., A.M.R.), Cork University Hospital; and Department of Neurology (O.H.), Beaumont Hospital, Dublin, Ireland.
authors.forename: Orla
authors.initials: O
authors.lastname: Hardiman
authors.affiliation: From the Department of Neurology (S.L., A.M.R.), Cork University Hospital; and Department of Neurology (O.H.), Beaumont Hospital, Dublin, Ireland.
authors.forename: Aisling M
authors.initials: AM
authors.lastname: Ryan
mesh_terms: D000328:Adult; D018672:Community Health Planning; D005260:Female; D006801:Humans; D007494:Ireland / Q000453:epidemiology; D008297:Male; D009468:Neuromuscular Diseases / Q000145:classification / Q000453:epidemiology*; D015995:Prevalence; D012189:Retrospective Studies