title: [A Case of Subacute Combined Degeneration Caused by Vitamin B12Deficiency in a Cervical Spondylosis Surgery Referral].
abstract: A 62-year-old man with a 1-year history of numbness of the extremities, clumsiness, and gait disorder was diagnosed with cervical spondylotic myelopathy at a neighboring clinic and referred to our institution for surgery. The patient had undergone a total gastrectomy 6 years previously. Flattening of the cervical cord, associated with diffuse cervical spondylosis and intramedullary intensity change, was observed on magnetic resonance imaging of the cervical spine. Neurological examination revealed decreased vibratory and position sense in all limbs, with posterior funiculus-based neurological symptoms. Blood biochemistry revealed decreased vitamin B12(VB12)levels and megaloblastic anemia. On the basis of these findings, the patient was diagnosed with subacute combined degeneration(SCD). The patient was treated with VB12for 3 months; the gait disorder resolved and the intramedullary intensity changes in the posterior column of the medulla oblongata, thoracicus, and spinal cord were no longer observed. SCD is a pathological condition in which recovery of neurological function may be achieved through early administration of VB12. In some cases, it is difficult to differentiate between this condition and cervical spondylotic myelopathy because both diseases exhibit progressive spinal symptoms. The medical history and results of neurological evaluations of the patient are important for an accurate diagnosis, and should therefore not be overlooked.
authors.affiliation: Department of Neurosurgery, Takeda General Hospital.
authors.forename: Kunio
authors.initials: K
authors.lastname: Yokoyama
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kawanishi
authors.forename: Akira
authors.initials: A
authors.lastname: Sugie
authors.forename: Makoto
authors.initials: M
authors.lastname: Yamada
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Tanaka
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Ito
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Kuroiwa
mesh_terms: D006801:Humans; D008297:Male; D008526:Medulla Oblongata; D008875:Middle Aged; D009460:Neurologic Examination; D012017:Referral and Consultation; D055009:Spondylosis / Q000000981:diagnostic imaging* / Q000209:etiology; D016896:Treatment Outcome; D014805:Vitamin B 12 / Q000627:therapeutic use; D014806:Vitamin B 12 Deficiency / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology
chemical_list: D014805:Vitamin B 12