title: Possible Molecular Mechanisms by which Vitamin D Prevents Inflammatory Bowel Disease and Colitis-associated Colorectal Cancer.
abstract: It is well accepted that inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, is one of high risk factors for colorectal cancer (CRC). This supports the notion that inflammation plays a key role in cancer development. Epidemiologic studies have shown that vitamin D (Vit D) deficiency is associated with IBD and various types of cancer including colorectal cancer. Clinical trials and mouse models have shown that Vit D is beneficial in preventing or ameliorating inflammation and carcinogenesis. Mechanism studies show that Vit D played wide-spectrum roles in anti-inflammation, immunoregulation, and anti-cancer activities. In this review, we summarized and updated the findings on Vit D, IBD and colitis-associated colorectal cancer (CAC) with the emphasis on the effects of Vit D on anti-inflammation, EMT and cancer stem cells (CSC).
authors.affiliation: Department of Gastroenterology, Peking Union Medical College Hospital, Beijing. China.
authors.forename: Zijian
authors.initials: Z
authors.lastname: Luan
authors.affiliation: The State Key Laboratory of Molecular Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing. China.
authors.forename: Yiming
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Department of Gastroenterology, Peking Union Medical College Hospital, Beijing. China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Xin
authors.affiliation: Department of Gastroenterology, Peking Union Medical College Hospital, Beijing. China.
authors.forename: Jiaming
authors.initials: J
authors.lastname: Qian
authors.affiliation: The State Key Laboratory of Molecular Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing. China.
authors.forename: Hongying
authors.initials: H
authors.lastname: Wang
mesh_terms: D015179:Colorectal Neoplasms / Q000150:complications / Q000517:prevention & control*; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications / Q000235:genetics / Q000517:prevention & control*; D015398:Signal Transduction; D014807:Vitamin D / Q000378:metabolism / Q000502:physiology*
chemical_list: D014807:Vitamin D
keywords: EMT; IBD; NF-κ B; Vitamin D; cancer stem cell; colitis-associated colorectal cancer; inflammation