title: Sleep-related disorders in Latin-American children with atopic dermatitis: A case control study.
abstract: BACKGROUND
  Atopic dermatitis (AD) has been associated with impairment of sleep. The aim of this study was to evaluate sleep disorders in AD Latin-American children (4-10 years) from nine countries, and in normal controls (C).
  
  
  METHODS
  Parents from 454 C and 340 AD children from referral clinics answered the Children Sleep Habits Questionnaire (CSHQ), a one-week retrospective 33 questions survey under seven items (bedtime resistance, sleep duration, sleep anxiety, night awakening, parasomnias, sleep-disordered breathing and daytime sleepiness). Total CSHQ score and items were analysed in both C and AD groups. Spearman's correlation coefficient between SCORAD (Scoring atopic dermatitis), all subscales and total CSHQ were also obtained.
  
  
  RESULTS
  C and AD groups were similar regarding age, however, significantly higher values for total CSHQ (62.2±16.1 vs 53.3±12.7, respectively) and items were observed among AD children in comparison to C, and they were higher among those with moderate (54.8%) or severe (4.3%) AD. Except for sleep duration (r=-0.02, p=0.698), there was a significant Spearman's correlation index for bedtime resistance (0.24, p<0.0001), sleep anxiety (0.29, p<0.0001), night awakening (0.36, p<0.0001), parasomnias (0.54, p<0.0001), sleep-disordered breathing (0.42, p<0.0001), daytime sleepiness (0.26, p<0.0001) and total CSHQ (0.46, p<0.0001). AD patients had significantly higher elevated body mass index.
  
  
  CONCLUSIONS
  Latin-American children with AD have sleep disorders despite treatment, and those with moderate to severe forms had marked changes in CSHQ.
authors.affiliation: Unipampa Federal University, Uruguaiana, Rio Grande do Sul, Brazil.
authors.forename: M
authors.initials: M
authors.lastname: Urrutia-Pereira
authors.affiliation: Division of Allergy and Clinical Immunology, Federal University of São Paulo, São Paulo, Brazil. Electronic address: dirceu.sole@unifesp.br.
authors.forename: D
authors.initials: D
authors.lastname: Solé
authors.affiliation: Department of Pediatrics, Federal University of Paraná, Paraná, Brazil.
authors.forename: N A
authors.initials: NA
authors.lastname: Rosario
authors.affiliation: Department of Pediatrics, Federal University of Paraná, Paraná, Brazil.
authors.forename: H J C
authors.initials: HJC
authors.lastname: Neto
authors.affiliation: Dr Avelino L. Castelán Pediatric Hospital, Chaco, Argentina.
authors.forename: V
authors.initials: V
authors.lastname: Acosta
authors.affiliation: Centro de Asma y Alergia, Tegucigalpa, Honduras.
authors.forename: C F
authors.initials: CF
authors.lastname: Almendarez
authors.affiliation: Allergy Service of the Hospital ISSSTE, Veracruz, Mexico.
authors.forename: M M
authors.initials: MM
authors.lastname: Avalos
authors.affiliation: Clínica Regional del Este, Córdoba, Argentina.
authors.forename: H
authors.initials: H
authors.lastname: Badellino
authors.affiliation: Centro de Medicina Avanzada Dr. Abel González, Dominican Republic.
authors.forename: F
authors.initials: F
authors.lastname: Berroa
authors.affiliation: Hospital Universitario General Calixto García, Cuba.
authors.forename: M
authors.initials: M
authors.lastname: Álvarez-Castelló
authors.affiliation: Centro de Medicina Avanzada Dr. Abel González, Dominican Republic.
authors.forename: A J
authors.initials: AJ
authors.lastname: Castillo
authors.affiliation: Centro Nacional de Biopreparados, Havana, Cuba.
authors.forename: R L
authors.initials: RL
authors.lastname: Castro-Almarales
authors.affiliation: Centro de Medicina Avanzada Dr. Abel González, Dominican Republic.
authors.forename: M M
authors.initials: MM
authors.lastname: De la Cruz
authors.affiliation: Hospital Universitario Metropolitano, Barranquilla, Colombia.
authors.forename: A M
authors.initials: AM
authors.lastname: Cepeda
authors.affiliation: Universidad Nacional Del Este, Asuncion, Paraguay.
authors.forename: C
authors.initials: C
authors.lastname: Fernandez
authors.affiliation: Centro de Pesquisa: Consultorios del médico de familia, Havana, Cuba.
authors.forename: M
authors.initials: M
authors.lastname: González-León
authors.affiliation: Centro Médico San Angel, Xalapa, Mexico.
authors.forename: J
authors.initials: J
authors.lastname: Lozano-Saenz
authors.affiliation: Hospital Universitario Infantil Sur, Cuba.
authors.forename: C
authors.initials: C
authors.lastname: Sanchez-Silot
authors.affiliation: Clínica de Alergia y Asma, Asuncion, Paraguay.
authors.forename: J C
authors.initials: JC
authors.lastname: Sisul-Alvariza
authors.affiliation: Hospital Pediatrico Pereira Rossell, Montevideo, Uruguay.
authors.forename: M
authors.initials: M
authors.lastname: Valentin-Rostan
authors.affiliation: ABC Foundation School of Medicine, Brazil.
authors.forename: R O S
authors.initials: ROS
authors.lastname: Sarni
mesh_terms: D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D003876:Dermatitis, Atopic / Q000150:complications*; D005260:Female; D006801:Humans; D007843:Latin America; D008297:Male; D012189:Retrospective Studies; D012893:Sleep Wake Disorders / Q000453:epidemiology* / Q000209:etiology*; D011795:Surveys and Questionnaires
keywords: Atopic dermatitis; Children; Questionnaire; SCORAD; Sleep disorders