title: Demographic and Clinical Characteristics of a Predominantly Hispanic Population with Inflammatory Bowel Disease on the US-Mexico Border.
abstract: OBJECTIVE
  Information regarding Hispanics with inflammatory bowel disease (IBD) is scarce. In this study we aimed to describe a predominantly Hispanic population with IBD in a city located along the US-Mexico border and to identify clinical or demographic differences between Hispanics and non-Hispanics.
  
  
  METHODS
  Retrospective cohort analysis of patients with IBD between 2003 and 2013 at a tertiary care center. Information collected included age, sex, ethnicity, diagnosis, diagnosis status (new vs old), endoscopic extent of disease (EOD), extraintestinal manifestations, medical treatment, and surgeries performed. Continuous and categorical variables were compared using a two-sided unpairedttest/Wilcoxon rank sum test and the Fisher exact test, respectively. Results withP≤ 5% were considered statistically significant.
  
  
  RESULTS
  Hispanics accounted for 71% of the population sample. A total of 141 patients (68%) were diagnosed as having ulcerative colitis (UC) and 67 (32%) as having Crohn disease (CD). The only statistically significant differences between Hispanics and non-Hispanics were older age at diagnosis and a higher proportion of new diagnoses in Hispanics with CD (P= 0.008 and 0.009, respectively) The most common EOD in patients with UC was extensive colitis, whereas isolated colonic disease predominated in CD, regardless of ethnicity. Immunomodulators and biologics were used in 3% and 1% of cases, respectively. Treatment regimens were similar in both ethnic groups. Patients with CD were more likely than those with UC to have undergone surgery (27% vs 11%,P= 0.004). Surgery rates did not differ between Hispanics and non-Hispanics.
  
  
  CONCLUSIONS
  In our population, UC was more common than CD, and the EOD of both conditions differed from the one previously described in other Hispanic populations in the United States. The use of immunomodulators and biologics is the lowest reported to date in the country. No clinically relevant differences were seen between Hispanics and non-Hispanics.
authors.affiliation: From the Department of Medicine, Division of Gastroenterology, the Division of Biostatistics & Epidemiology, and the Division of Biostatistics, Texas Tech University Health Sciences Center at El Paso, and the Paul L. Foster School of Medicine, Texas Tech University, El Paso.
authors.forename: Antonio
authors.initials: A
authors.lastname: Mendoza Ladd
authors.affiliation: From the Department of Medicine, Division of Gastroenterology, the Division of Biostatistics & Epidemiology, and the Division of Biostatistics, Texas Tech University Health Sciences Center at El Paso, and the Paul L. Foster School of Medicine, Texas Tech University, El Paso.
authors.forename: Yi
authors.initials: Y
authors.lastname: Jia
authors.affiliation: From the Department of Medicine, Division of Gastroenterology, the Division of Biostatistics & Epidemiology, and the Division of Biostatistics, Texas Tech University Health Sciences Center at El Paso, and the Paul L. Foster School of Medicine, Texas Tech University, El Paso.
authors.forename: Christine
authors.initials: C
authors.lastname: Yu
authors.affiliation: From the Department of Medicine, Division of Gastroenterology, the Division of Biostatistics & Epidemiology, and the Division of Biostatistics, Texas Tech University Health Sciences Center at El Paso, and the Paul L. Foster School of Medicine, Texas Tech University, El Paso.
authors.forename: Sherif
authors.initials: S
authors.lastname: Elhanafi
authors.affiliation: From the Department of Medicine, Division of Gastroenterology, the Division of Biostatistics & Epidemiology, and the Division of Biostatistics, Texas Tech University Health Sciences Center at El Paso, and the Paul L. Foster School of Medicine, Texas Tech University, El Paso.
authors.forename: Alok
authors.initials: A
authors.lastname: Dwivedi
authors.affiliation: From the Department of Medicine, Division of Gastroenterology, the Division of Biostatistics & Epidemiology, and the Division of Biostatistics, Texas Tech University Health Sciences Center at El Paso, and the Paul L. Foster School of Medicine, Texas Tech University, El Paso.
authors.forename: Jiayang
authors.initials: J
authors.lastname: Liu
authors.affiliation: From the Department of Medicine, Division of Gastroenterology, the Division of Biostatistics & Epidemiology, and the Division of Biostatistics, Texas Tech University Health Sciences Center at El Paso, and the Paul L. Foster School of Medicine, Texas Tech University, El Paso.
authors.forename: Giangqing
authors.initials: G
authors.lastname: Song
authors.affiliation: From the Department of Medicine, Division of Gastroenterology, the Division of Biostatistics & Epidemiology, and the Division of Biostatistics, Texas Tech University Health Sciences Center at El Paso, and the Paul L. Foster School of Medicine, Texas Tech University, El Paso.
authors.forename: Mark
authors.initials: M
authors.lastname: Hall
authors.affiliation: From the Department of Medicine, Division of Gastroenterology, the Division of Biostatistics & Epidemiology, and the Division of Biostatistics, Texas Tech University Health Sciences Center at El Paso, and the Paul L. Foster School of Medicine, Texas Tech University, El Paso.
authors.forename: Marc J
authors.initials: MJ
authors.lastname: Zuckerman
mesh_terms: D000328:Adult; D000367:Age Factors; D001688:Biological Products / Q000627:therapeutic use; D003093:Colitis, Ulcerative / Q000188:drug therapy / Q000208:ethnology / Q000473:pathology*; D003113:Colonoscopy / Q000706:statistics & numerical data; D003424:Crohn Disease / Q000188:drug therapy / Q000208:ethnology / Q000473:pathology*; D003710:Demography; D005260:Female; D006630:Hispanic or Latino / Q000706:statistics & numerical data*; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D008297:Male; D008800:Mexico / Q000208:ethnology; D008875:Middle Aged; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D014481:United States
chemical_list: D001688:Biological Products; D007155:Immunologic Factors