title: High expression of CEACAM19, a new member of carcinoembryonic antigen gene family, in patients with breast cancer.
abstract: Carcinoembryonic antigen (CEA) family members play important roles in malignancies and are introduced as biomarkers in different types of cancers. Among them CEACAM19 (CEAL1) gene, a new member of the CEA family, remains to be fully elucidated. The aim of this study was investigating the mRNA expression level of CEACAM19 in tumor samples of breast cancer patients compared to breast tissue of normal individuals. We evaluated the expression level of this gene in 75 breast tumors by using real-time quantitative PCR. Also, we studied the correlation between CEACAM19 expression and clinicopathological features and hormone receptors status, including estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 of patients. Out of the enrolled patients, six of them (7.9%) showed low expression, ten (13.2%) showed normal expression and 59 (77.6%) showed high expression of CEACAM19. There was a significant correlation between high expression of CEACAM19 gene in tumor samples compared to normal tissues (P = 0.039). No significant correlation was seen between clinicopathological factors and disease-free survival with mRNA levels of CEACAM19 in tumor samples, while the difference between the expression of CEACAM19 in ER/PR-positive and ER/PR-negative breast cancer patients was statistically significant (P = 0.046). In conclusion, CEACAM19 showed high expression in tumor samples compared to normal mammary tissue. In addition, CEACAM19 may represent as a novel therapeutic target in certain subgroups of breast cancer patients such as ER/PR-negative. Critical roles of CEA proteins in tumor progression may nominate them as robust potential targets for therapeutic intervention in near future.
authors.affiliation: Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mehrdad Asghari
authors.initials: MA
authors.lastname: Estiar
authors.affiliation: Cancer Genetics Department, Breast Cancer Research Center (BCRC), ACECR, No. 146, South Gandi St, Vanak Square, Tehran, 1517964311, Iran.
authors.forename: Rezvan
authors.initials: R
authors.lastname: Esmaeili
authors.affiliation: Recombinant Proteins Department, Breast Cancer Research Center, ACECR, Tehran, Iran.
authors.forename: Ali-Akbar
authors.initials: AA
authors.lastname: Zare
authors.affiliation: Cancer Genetics Department, Breast Cancer Research Center (BCRC), ACECR, No. 146, South Gandi St, Vanak Square, Tehran, 1517964311, Iran.
authors.forename: Leila
authors.initials: L
authors.lastname: Farahmand
authors.affiliation: Instituto de Neurociencias UMH-SIC, Alicante, Spain.
authors.forename: Hassan
authors.initials: H
authors.lastname: Fazilaty
authors.affiliation: Department of Medical Genetics and Molecular Biology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Zekri
authors.affiliation: Cancer Genetics Department, Breast Cancer Research Center (BCRC), ACECR, No. 146, South Gandi St, Vanak Square, Tehran, 1517964311, Iran.
authors.forename: Narges
authors.initials: N
authors.lastname: Jafarbeik-Iravani
authors.affiliation: Cancer Genetics Department, Breast Cancer Research Center (BCRC), ACECR, No. 146, South Gandi St, Vanak Square, Tehran, 1517964311, Iran. kmajidzadeh@razi.tums.ac.ir.
authors.forename: Keivan
authors.initials: K
authors.lastname: Majidzadeh-A
mesh_terms: D000328:Adult; D000951:Antigens, Neoplasm / Q000032:analysis*; D001943:Breast Neoplasms / Q000473:pathology*; D016022:Case-Control Studies; D015815:Cell Adhesion Molecules / Q000032:analysis*; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D008875:Middle Aged; D060888:Real-Time Polymerase Chain Reaction; D055815:Young Adult
chemical_list: D000951:Antigens, Neoplasm; C476062:CEACAM19 protein, human; D015815:Cell Adhesion Molecules
keywords: Biomarker; Breast cancer; CEA; CEACAM19