title: Octreotide use in post-cardiac surgery chylothorax: a 12-year perspective.
abstract: Background Chylothorax following cardiothoracic surgery is a rare condition in pediatric patients with significant morbidity and mortality. Pharmacological management with octreotide suggests possible efficacy; however, current evidence is inadequate. The objective of this study was to assess the safety and efficacy of octreotide as a therapeutic option in this clinical setting. Methods This was a 12-year single-center retrospective cohort study of all patients (birth to 18-years old) who received octreotide for management of post-cardiac surgery chylothorax between January 2003 to August 2015. The primary efficacy endpoint was resolution of chylothorax, categorized as complete (<2 mL·kg-1·day-1), partial (based on physician's judgement), or failed. The primary safety endpoint was any significant adverse drug reaction leading to discontinuation of octreotide therapy. Of the 46 patients identified as receiving octreotide for post-cardiac surgery chylothorax, 29 were included in efficacy and safety analyses. Results Resolution of chylothorax was achieved in 62% (complete in 28%, partial in 34%) of the total sample. The 38% who did not respond to octreotide therapy required thoracic duct ligation. The mean initial dose and duration of octreotide was 4 ± 3 µg·kg-1·h-1and 10 ± 5 days, respectively. Besides minor side-effects including transient hyperglycemia (45%), abdominal distension (3%), and tachycardia (>150 beats·min-1; 10%), no patient developed a significant side-effect that required discontinuation of therapy. Conclusions Pharmacological management of post-cardiac surgery induced chylothorax with octreotide shows promising benefits with an acceptable safety profile.
authors.affiliation: Division of Pharmaceutical Care, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia Both Abdulrazaq Aljazairi Sheikh and Tauhid Ahmed contributed equally to establish co-authorship.
authors.forename: Abdulrazaq Sheikh
authors.initials: AS
authors.lastname: Aljazairi
authors.affiliation: Division of Pharmaceutical Care, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia Both Abdulrazaq Aljazairi Sheikh and Tauhid Ahmed contributed equally to establish co-authorship.
authors.forename: Tauhid Ahmed
authors.initials: TA
authors.lastname: Bhuiyan
authors.affiliation: Division of Pharmaceutical Care, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia Both Abdulrazaq Aljazairi Sheikh and Tauhid Ahmed contributed equally to establish co-authorship.
authors.forename: Abdullah Hasan
authors.initials: AH
authors.lastname: Alwadai
authors.affiliation: Division of Pharmaceutical Care, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia Both Abdulrazaq Aljazairi Sheikh and Tauhid Ahmed contributed equally to establish co-authorship.
authors.forename: Rayd Abdulaziz
authors.initials: RA
authors.lastname: Almehizia
mesh_terms: D000293:Adolescent; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D002916:Chylothorax / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology / Q000601:surgery; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008026:Ligation; D008297:Male; D015282:Octreotide / Q000009:adverse effects / Q000627:therapeutic use*; D012189:Retrospective Studies; D012529:Saudi Arabia; D013897:Thoracic Duct / Q000601:surgery; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D015282:Octreotide
keywords: Cardiac surgical procedures; Chylothorax; Heart defects; Octreotide; Postoperative complications; Treatment outcome; congenital