title: Diagnostic performance of peroxiredoxin 1 to determine time-of-onset of acute cerebral infarction.
abstract: Accurately determining time-of-onset of cerebral infarction is important to clearly identify patients who could benefit from reperfusion therapies. We assessed the kinetics of peroxiredoxin 1 (PRDX1), a protein involved in oxidative stress during the acute phase of ischemia, and its ability to determine stroke onset in a population of patients with known onset of less than 24 hours and in a control group. Median PRDX1 levels were significantly higher in stroke patients compared to controls. PRDX1 levels were also higher from blood samples withdrawn before vs. after 3 hours following stroke onset, and before vs. after 6 hours. ROC analysis with area under the curve (AUC), sensitivity (Se) and specificity (Sp) determined from the Youden index was performed to assess the ability of PRDX1 levels to determine onset. Diagnostic performances of PRDX1 levels were defined by an AUC of 69%, Se of 53% and Sp of 86% for identifying cerebral infarction occurring <3 hours, and an AUC of 68%, Se of 49% and Sp of 88% for cerebral infarction occurring <6 hours. These first results suggest that PRDX1 levels could be the basis of a new method using biomarkers for determining cerebral infarction onset.
authors.affiliation: Department of Neurology, Stroke Unit, University Hospital of Nancy, 54035 Nancy, France.|Centre d'Investigation Clinique Plurithématique CIC 1433, University Hospital of Nancy, 54500 Vandoeuvre-lès-Nancy, France.|Department of Human Protein Sciences, University Medical Center, 1206 Geneva, Switzerland.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Richard
authors.affiliation: Department of Human Protein Sciences, University Medical Center, 1206 Geneva, Switzerland.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Lapierre
authors.affiliation: Centre d'Investigation Clinique Plurithématique CIC 1433, University Hospital of Nancy, 54500 Vandoeuvre-lès-Nancy, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Girerd
authors.affiliation: Department of Neurology, Stroke Unit, University Hospital of Nancy, 54035 Nancy, France.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Bonnerot
authors.affiliation: Department of Neurology, University Hospital of Geneva, 1205 Geneva, Switzerland.
authors.forename: Pierre R
authors.initials: PR
authors.lastname: Burkhard
authors.affiliation: Department of Human Protein Sciences, University Medical Center, 1206 Geneva, Switzerland.
authors.forename: Linnéa
authors.initials: L
authors.lastname: Lagerstedt
authors.affiliation: Department of Neuroradiology, University Hospital of Nancy, 54035 Nancy, France.
authors.forename: Serge
authors.initials: S
authors.lastname: Bracard
authors.affiliation: Department of Neurology, Stroke Unit, University Hospital of Nancy, 54035 Nancy, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Debouverie
authors.affiliation: Department of Human Protein Sciences, University Medical Center, 1206 Geneva, Switzerland.
authors.forename: Natacha
authors.initials: N
authors.lastname: Turck
authors.affiliation: Department of Human Protein Sciences, University Medical Center, 1206 Geneva, Switzerland.
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Sanchez
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002544:Cerebral Infarction / Q000097:blood / Q000175:diagnosis* / Q000235:genetics* / Q000503:physiopathology; D005260:Female; D015870:Gene Expression; D006801:Humans; D008297:Male; D008875:Middle Aged; D054464:Peroxiredoxins / Q000097:blood / Q000235:genetics*; D012372:ROC Curve; D013997:Time Factors
chemical_list: D015415:Biomarkers; C515940:PRDX1 protein, human; D054464:Peroxiredoxins