title: New Furanone Derivatives and Alkaloids from the Co-Culture of Marine-Derived Fungi Aspergillus sclerotiorum and Penicillium citrinum.
abstract: Six new compounds including two furanone derivatives sclerotiorumins A and B (1 and 2), one novel oxadiazin derivative sclerotiorumin C (3), one pyrrole derivative 1-(4-benzyl-1H-pyrrol-3-yl)ethanone (4), and two complexes of neoaspergillic acid aluminiumneohydroxyaspergillin (5) and ferrineohydroxyaspergillin (6) were isolated from the co-culture of marine-derived fungi Aspergillus sclerotiorum and Penicillium citrinum. Compound 3 was the first natural 1,2,4-oxadiazin-6-one. Compound 5 showed significant and selective cytotoxicity against human histiocytic lymphoma U937 cell line (IC50= 4.2 μm) and strong toxicity towards brine shrimp (LC50= 6.1 μm), and oppositely increased the growth and biofilm formation of Staphylococcus aureus.
authors.affiliation: Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Material Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou, 510301, P. R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Bao
authors.affiliation: Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Material Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou, 510301, P. R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Wang
authors.affiliation: Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Material Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou, 510301, P. R. China.
authors.forename: Xiao-Yong
authors.initials: XY
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Material Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou, 510301, P. R. China.
authors.forename: Xu-Hua
authors.initials: XH
authors.lastname: Nong
authors.affiliation: Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Material Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou, 510301, P. R. China.
authors.forename: Shu-Hua
authors.initials: SH
authors.lastname: Qi
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001156:Artemia / Q000187:drug effects / Q000254:growth & development; D001230:Aspergillus / Q000737:chemistry* / Q000254:growth & development / Q000378:metabolism; D018441:Biofilms / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D005663:Furans / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D010407:Penicillium / Q000737:chemistry* / Q000254:growth & development / Q000378:metabolism; D013211:Staphylococcus aureus / Q000187:drug effects / Q000502:physiology; D020298:U937 Cells
chemical_list: D000470:Alkaloids; D000900:Anti-Bacterial Agents; D005663:Furans
keywords: 
  Aspergillus sclerotiorum
  ; 1,2,4-Oxadiazin-6-one; Complexes of neoaspergillic acid; Cytotoxic activities; Furanone derivatives