title: Coordination-induced decomposition of luminescent gold nanoparticles: sensitive detection of H2O2and glucose.
abstract: The surface inert of luminescent gold nanoparticles (AuNPs) toward biomolecules set a challenge to further exploit their bioanalytical applications using the direct luminescence response. Herein, we report a novel approach to induce significant luminescence quenching of the AuNPs upon the interaction with a metal coordination ligand tris(2-carboxyethyl)phosphine (TCEP), providing a strategy for the detection of H2O2with a limit of detection (LOD) of 14 nM through the reaction between H2O2and TCEP to protect the luminescence quenching of the AuNPs. Furthermore, this strategy is also extended for sensitive and selective detection of glucose with a LOD of 1.1 μM based on monitoring the production of H2O2catalyzed from the oxidation of glucose. The highly extendable feature of this strategy can have great potential in the sensitive detection of other biomolecules. Graphical Abstract A facile and extendable strategy has been developed for the sensitive detection of H2O2and glucose based on the interaction between luminescent gold nanoparticles and TCEP, a metal coordination ligand.
authors.affiliation: Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, Guangdong, 510640, China.|School of Chemistry and Chemical Engineering, Gannan Normal University, Ganzhou, Jiangxi, 341000, China.
authors.forename: Xiaoqi
authors.initials: X
authors.lastname: Lai
authors.affiliation: Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, Guangdong, 510640, China.|School of Chemistry and Chemical Engineering, Gannan Normal University, Ganzhou, Jiangxi, 341000, China.
authors.forename: Fengxian
authors.initials: F
authors.lastname: Luo
authors.affiliation: Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, Guangdong, 510640, China.
authors.forename: Yaping
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, Guangdong, 510640, China.
authors.forename: Xuxian
authors.initials: X
authors.lastname: Su
authors.affiliation: Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, Guangdong, 510640, China. cejbliu@scut.edu.cn.
authors.forename: Jinbin
authors.initials: J
authors.lastname: Liu
mesh_terms: D015374:Biosensing Techniques / Q000379:methods; D005947:Glucose / Q000032:analysis*; D006046:Gold / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000032:analysis*; D057230:Limit of Detection; D049449:Luminescence; D049408:Luminescent Agents / Q000737:chemistry*; D008163:Luminescent Measurements / Q000379:methods*; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010084:Oxidation-Reduction; D010720:Phosphines / Q000737:chemistry*
chemical_list: D005947:Glucose; D006046:Gold; D006861:Hydrogen Peroxide; D049408:Luminescent Agents; D010720:Phosphines; C080938:tris(2-carboxyethyl)phosphine
keywords: Coordination; Decomposition; Glucose; H2O2; Luminescent gold nanoparticle