title: Genetic Variation in One-Carbon Metabolism and Changes in Metabolic Parameters in First-Episode Schizophrenia Patients.
abstract: In this study, we aimed to investigate the effects of polymorphisms in genes encoding 1-carbon metabolism enzymes on differential development of metabolic parameters during 12 weeks of treatment with second-generation antipsychotics in first-episode schizophrenia patients.
  
  
  
  The following polymorphisms in 1-carbon metabolism genes were genotyped: MTHFR (C677T and A1298C), MTHFD1 (G1958A), MTRR (A66G), and BHMT (G742A). A broad panel of metabolic parameters including body mass index, waist circumference, total cholesterol low and high density lipoproteins, triglycerides, homocysteine, folate, and vitamin B12 was determined.
  
  
  
  There was a significant effect of the interaction between the MTHFR C677T polymorphism and time on body mass index and waist circumference in the allelic and genotype analyses. Indeed, patients with the MTHFR 677CC genotype had higher increase in body mass index and waist circumference compared with other corresponding genotypes or the MTHFR 677T allele carriers (CT and TT genotypes). In addition, patients with the MTHFR 677TT genotype had higher waist circumference in all time points. Similarly, patients with the MTHFR 677TT genotype had higher body mass index in all time points, but this effect was not significant after correction for multiple testing.
  
  
  
  Our results indicate that the MTHFR C677T polymorphism may predict antipsychotic-induced weight gain. Effects of the MTHFR C677T polymorphism might be different in initial exposure to antipsychotics compared with long-term perspective.
authors.affiliation: Department of Psychiatry, Wroclaw Medical University, Wroclaw, Poland; Department of Genetics, Wroclaw Medical University, Wroclaw, Poland; Department of Endocrinology and Diabetology, Wroclaw, Poland.
authors.forename: Blazej
authors.initials: B
authors.lastname: Misiak
authors.affiliation: Department of Psychiatry, Wroclaw Medical University, Wroclaw, Poland; Department of Genetics, Wroclaw Medical University, Wroclaw, Poland; Department of Endocrinology and Diabetology, Wroclaw, Poland.
authors.forename: Lukasz
authors.initials: L
authors.lastname: Laczmanski
authors.affiliation: Department of Psychiatry, Wroclaw Medical University, Wroclaw, Poland; Department of Genetics, Wroclaw Medical University, Wroclaw, Poland; Department of Endocrinology and Diabetology, Wroclaw, Poland.
authors.forename: Natalia Kinga
authors.initials: NK
authors.lastname: Sloka
authors.affiliation: Department of Psychiatry, Wroclaw Medical University, Wroclaw, Poland; Department of Genetics, Wroclaw Medical University, Wroclaw, Poland; Department of Endocrinology and Diabetology, Wroclaw, Poland.
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Szmida
authors.affiliation: Department of Psychiatry, Wroclaw Medical University, Wroclaw, Poland; Department of Genetics, Wroclaw Medical University, Wroclaw, Poland; Department of Endocrinology and Diabetology, Wroclaw, Poland.
authors.forename: Ryszard
authors.initials: R
authors.lastname: Slezak
authors.affiliation: Department of Psychiatry, Wroclaw Medical University, Wroclaw, Poland; Department of Genetics, Wroclaw Medical University, Wroclaw, Poland; Department of Endocrinology and Diabetology, Wroclaw, Poland.
authors.forename: Patryk
authors.initials: P
authors.lastname: Piotrowski
authors.affiliation: Department of Psychiatry, Wroclaw Medical University, Wroclaw, Poland; Department of Genetics, Wroclaw Medical University, Wroclaw, Poland; Department of Endocrinology and Diabetology, Wroclaw, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Kiejna
authors.affiliation: Department of Psychiatry, Wroclaw Medical University, Wroclaw, Poland; Department of Genetics, Wroclaw Medical University, Wroclaw, Poland; Department of Endocrinology and Diabetology, Wroclaw, Poland.
authors.forename: Dorota
authors.initials: D
authors.lastname: Frydecka
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use; D050940:Betaine-Homocysteine S-Methyltransferase / Q000235:genetics; D015992:Body Mass Index; D005260:Female; D005287:Ferredoxin-NADP Reductase / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008754:Methylenetetrahydrofolate Dehydrogenase (NADP) / Q000235:genetics; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D015778:Minor Histocompatibility Antigens / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics*; D012559:Schizophrenia / Q000188:drug therapy / Q000235:genetics*; D055105:Waist Circumference / Q000187:drug effects / Q000235:genetics; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D015778:Minor Histocompatibility Antigens; C111241:methionine synthase reductase; D005287:Ferredoxin-NADP Reductase; C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2); C539735:MTHFD1 protein, human; D008754:Methylenetetrahydrofolate Dehydrogenase (NADP); C494548:BHMT protein, human; D050940:Betaine-Homocysteine S-Methyltransferase
keywords: MTHFR; antipsychotic-induced weight gain; metabolic syndrome; methylenetetrahydrofolate reductase; polymorphism