title: Transarterial embolization with bleomycin for symptomatic hepatic focal nodular hyperplasia.
abstract: OBJECTIVE
  We aimed to evaluate the therapeutic effect and safety of transarterial embolization using bleomycin-iodinated oil and polyvinyl alcohol particles for the treatment of symptomatic hepatic focal nodular hyperplasia (FNH).
  
  
  METHODS
  This retrospective study included 23 consecutive patients with symptomatic hepatic FNH, who underwent embolization using bleomycin-iodinated oil and polyvinyl alcohol particles between January 2005 and December 2012. Patients were followed-up with radiologic and clinical evaluation. Therapeutic effects including changes in lesion size and symptomatic improvement were evaluated after the procedure.
  
  
  RESULTS
  Embolization was performed for 27 lesions in 23 patients. Follow-up period ranged from three months to 89 months. The mean lesion diameters decreased significantly from 5.0±2.4 cm to 3.2±1.5 cm at 3-9 months after embolization (P < 0.001). Five lesions had complete resolution in the follow-up period. The clinical symptoms were significantly relieved in all patients. Contrast-enhanced scans at follow-up showed complete lack of residual arterial blood supply in the majority of lesions. Local recurrence was found in one treated lesion at the 54-month follow-up. There were no major complications associated with the procedure.
  
  
  CONCLUSIONS
  Transarterial embolization using bleomycin-iodinated oil and polyvinyl alcohol particles for hepatic FNH is a safe and effective alternative treatment with good long-term symptomatic control and reduction in lesion size after embolization.
authors.affiliation: Department of Interventional Radiology, Chinese PLA General Hospital, Beijing, China. wangmq@vip.sina.com.
authors.forename: Guodong
authors.initials: G
authors.lastname: Zhang
authors.forename: Maoqiang
authors.initials: M
authors.lastname: Wang
authors.forename: Feng
authors.initials: F
authors.lastname: Duan
authors.forename: Kai
authors.initials: K
authors.lastname: Yuan
authors.forename: Kai
authors.initials: K
authors.lastname: Li
authors.forename: Jieyu
authors.initials: J
authors.lastname: Yan
authors.forename: Zhongfei
authors.initials: Z
authors.lastname: Chang
mesh_terms: D000293:Adolescent; D000328:Adult; D001761:Bleomycin / Q000008:administration & dosage*; D004621:Embolization, Therapeutic / Q000379:methods*; D005260:Female; D020518:Focal Nodular Hyperplasia / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008297:Male; D011142:Polyvinyl Alcohol / Q000008:administration & dosage; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D001761:Bleomycin; D011142:Polyvinyl Alcohol