title: Meta-Analysis of Impact of Diabetes Mellitus on Outcomes After Transcatheter Aortic Valve Implantation.
abstract: To date, the impact of diabetes mellitus (DM) on prognosis after transcatheter aortic valve implantation (TAVI) is still contradictory and thus merits further investigation. The purpose of this meta-analysis was to evaluate the impact of DM on outcomes after TAVI. A systematic search of the PubMed database was performed. Primary end points were 30-day and 1-year all-cause mortality after TAVI. Risk ratios (RRs) and 95% CIs were calculated using the random-effect or fixed-effect model, depending on heterogeneity between studies, and p values <0.05 was considered significant. A total of 16 studies involving 13,253 patients were included in our meta-analysis. There was no significant difference between the groups with DM and without DM regarding 30-day (RR 1.07, 95% CI 0.90 to 1.27, p = 0.45) or 1-year (RR 1.04, 95% CI 0.94 to 1.15, p = 0.42) all-cause mortality. The risks of 30-day complications, including myocardial infarction, stroke, major vascular complications, major bleeding, and acute kidney injury, were similar between patients with and without DM. In conclusion, DM neither affected short- or mid-term all-cause mortality nor short-term complications after TAVI.
authors.affiliation: Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
authors.forename: Yinghao
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Cardiology, Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
authors.forename: Xianbao
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Cardiology, Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
authors.forename: Yuxin
authors.initials: Y
authors.lastname: He
authors.affiliation: Department of Cardiology, Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
authors.forename: Mengyao
authors.initials: M
authors.lastname: Tang
authors.affiliation: Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
authors.forename: Qifeng
authors.initials: Q
authors.lastname: Zhu
authors.affiliation: Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
authors.forename: Xiaobin
authors.initials: X
authors.lastname: Xu
authors.affiliation: Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
authors.forename: Dongyu
authors.initials: D
authors.lastname: Guo
authors.affiliation: Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
authors.forename: Keda
authors.initials: K
authors.lastname: Shi
authors.affiliation: Department of Cardiology, Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
authors.forename: Po
authors.initials: P
authors.lastname: Hu
authors.affiliation: Department of Cardiology, Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
authors.forename: Lihan
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
authors.forename: Huijia
authors.initials: H
authors.lastname: Kong
authors.affiliation: Department of Cardiology, Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
authors.forename: Jubo
authors.initials: J
authors.lastname: Jiang
authors.affiliation: Department of Cardiology, Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Lin
authors.affiliation: Department of Cardiology, Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
authors.forename: Qiyuan
authors.initials: Q
authors.lastname: Xu
authors.affiliation: Department of Cardiology, Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
authors.forename: Feng
authors.initials: F
authors.lastname: Gao
authors.affiliation: Zhejiang University School of Medicine, Hangzhou, People's Republic of China; Department of Cardiology, Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, People's Republic of China. Electronic address: jian_an_wang@yahoo.com.
authors.forename: Jian'an
authors.initials: J
authors.lastname: Wang
mesh_terms: D058186:Acute Kidney Injury / Q000453:epidemiology; D001024:Aortic Valve Stenosis / Q000453:epidemiology / Q000601:surgery*; D002423:Cause of Death; D015897:Comorbidity; D003920:Diabetes Mellitus / Q000453:epidemiology*; D006801:Humans; D009026:Mortality; D009203:Myocardial Infarction / Q000453:epidemiology; D011183:Postoperative Complications / Q000453:epidemiology*; D019106:Postoperative Hemorrhage / Q000453:epidemiology; D011379:Prognosis; D020521:Stroke / Q000453:epidemiology; D065467:Transcatheter Aortic Valve Replacement