title: Renal Denervation Improves the Baroreflex and GABA System in Chronic Kidney Disease-induced Hypertension.
abstract: Hypertensive rats with chronic kidney disease (CKD) exhibit enhanced gamma-aminobutyric acid (GABA)Breceptor function and regulation within the nucleus tractus solitarii (NTS). For CKD with hypertension, renal denervation (RD) interrupts the afferent renal sympathetic nerves, which are connecting to the NTS. The objective of the present study was to investigate how RD improves CKD-induced hypertension. Rats underwent 5/6 nephrectomy for 8 weeks, which induced CKD and hypertension. RD was induced by applying phenol to surround the renal artery in CKD. RD improved blood pressure (BP) by lowering sympathetic nerve activity and markedly restored the baroreflex response in CKD. The GABABreceptor expression was increased in the NTS of CKD; moreover, the central GABA levels were reduced in the cerebrospinal fluid, and the peripheral GABA levels were increased in the serum. RD restored the glutamic acid decarboxylase activity in the NTS in CKD, similar to the effect observed for central treatment with baclofen, and the systemic administration of gabapentin reduced BP. RD slightly improved renal function and cardiac load in CKD. RD may improve CKD-induced hypertension by modulating the baroreflex response, improving GABA system dysfunction and preventing the development and reducing the severity of cardiorenal syndrome type 4 in CKD rats.
authors.affiliation: Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.|Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan.|Yuh-Ing Junior College of Health Care &Management, Kaohsiung, Taiwan.
authors.forename: Hsin-Hung
authors.initials: HH
authors.lastname: Chen
authors.affiliation: Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.|Yuh-Ing Junior College of Health Care &Management, Kaohsiung, Taiwan.
authors.forename: Pei-Wen
authors.initials: PW
authors.lastname: Cheng
authors.affiliation: Division of General Internal Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
authors.forename: Wen-Yu
authors.initials: WY
authors.lastname: Ho
authors.affiliation: Graduate Institute of Clinical Medicine, National Cheng-Kung University, Tainan, Taiwan.
authors.forename: Pei-Jung
authors.initials: PJ
authors.lastname: Lu
authors.affiliation: Cardiovascular Center, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
authors.forename: Chi-Cheng
authors.initials: CC
authors.lastname: Lai
authors.affiliation: Department of Pathology and Laboratory Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
authors.forename: Yang-Ming
authors.initials: YM
authors.lastname: Tseng
authors.affiliation: Division of Nephrology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
authors.forename: Hua-Chang
authors.initials: HC
authors.lastname: Fang
authors.affiliation: Department of Anesthesiology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
authors.forename: Gwo-Ching
authors.initials: GC
authors.lastname: Sun
authors.affiliation: Genomics Research Center, Academia Sinica, Taipei, Taiwan.
authors.forename: Michael
authors.initials: M
authors.lastname: Hsiao
authors.affiliation: Department of Administration, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.|Section of Cardiology, Department of Medcine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
authors.forename: Chun-Peng
authors.initials: CP
authors.lastname: Liu
authors.affiliation: Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.|Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan.|Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan.|Institute of Biomedical Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan.
authors.forename: Ching-Jiunn
authors.initials: CJ
authors.lastname: Tseng
mesh_terms: D000818:Animals; D017704:Baroreflex / Q000187:drug effects / Q000502:physiology*; D001794:Blood Pressure / Q000187:drug effects; D003714:Denervation / Q000379:methods; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D006977:Hypertension, Renal / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D007668:Kidney / Q000187:drug effects / Q000294:innervation* / Q000503:physiopathology; D009392:Nephrectomy / Q000009:adverse effects; D009393:Nephritis / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D009475:Neurons, Afferent / Q000187:drug effects; D019800:Phenol / Q000009:adverse effects; D051381:Rats; D018080:Receptors, GABA-B / Q000378:metabolism; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D017552:Solitary Nucleus / Q000378:metabolism / Q000503:physiopathology
chemical_list: D018080:Receptors, GABA-B; D019800:Phenol