title: Preparation of quantum dots CdTe decorated graphene composite for sensitive detection of uric acid and dopamine.
abstract: The assembly of quantum dots (QDs) in a simply method opens up opportunities to obtain access to the full potential of assembled QDs by virtue of the collective properties of the ensembles. In this study, quantum dots CdTe and graphene (Gr) nanocomposite was constructed for the simultaneous determination of uric acid (UA) and dopamine (DA). The CdTe QDs-Gr nanocomposite was prepared by ultrasonication and was characterized with microscopic techniques. The nanocomposite modified electrode was characterized by cyclicvoltammetry (CV), differential pulse voltammetry (DPV) and electrochemical impedance spectroscopy (EIS). Due to the synergistic effects between CdTe QDs and Gr, the fabricated electrode exhibited excellent electrochemical catalytic activities, good biological compatibility and high sensitivity toward the oxidation of UA and DA. Under optimum conditions, in the co-existence system the linear calibration plots for UA and DA were obtained over the range of 3-600 μM and 1-500 μM with detection limits of 1.0 μM and 0.33 μM. The fabricated biosensor also exhibits the excellent repeatability, reproducibility, storage stability along with acceptable selectivity.
authors.affiliation: The First Affiliated Hospital of the Harbin Medical University, No. 23 Youzheng Street, Harbin, Heilongjiang Province, 150001, China.
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: Yu
authors.affiliation: The First Affiliated Hospital of the Harbin Medical University, No. 23 Youzheng Street, Harbin, Heilongjiang Province, 150001, China.
authors.forename: Jing-Hui
authors.initials: JH
authors.lastname: Jiang
authors.affiliation: Department of Clinical Laboratory, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, No. 2800 Gongwei Road, Huinan Town, Pudong, Shanghai, 201399, China.
authors.forename: Ze
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Jilin Cancer Hospital, Chaoyang District, Changchun City, Jilin province, Lake Road No.1018, China.
authors.forename: Guang-Cai
authors.initials: GC
authors.lastname: Wan
authors.affiliation: The First Hospital of Suihua, Suihua, Heilongjiang, 152000, China.
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Liu
authors.affiliation: The First Affiliated Hospital of the Harbin Medical University, No. 23 Youzheng Street, Harbin, Heilongjiang Province, 150001, China; Department of Clinical Laboratory, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, No. 2800 Gongwei Road, Huinan Town, Pudong, Shanghai, 201399, China. Electronic address: dongchang1969@163.com.
authors.forename: Dong
authors.initials: D
authors.lastname: Chang
authors.affiliation: Public Health School, Harbin Medical University, No. 157 Baojian Road, Nangang District, Harbin, Heilongjiang, 150081, China.
authors.forename: Hong-Zhi
authors.initials: HZ
authors.lastname: Pan
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D019187:Cadmium Compounds / Q000737:chemistry*; D058266:Dielectric Spectroscopy; D004298:Dopamine / Q000652:urine*; D004566:Electrodes; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D057230:Limit of Detection; D053761:Nanocomposites / Q000737:chemistry*; D010084:Oxidation-Reduction; D045663:Quantum Dots; D015203:Reproducibility of Results; D013691:Tellurium / Q000737:chemistry*; D014527:Uric Acid / Q000652:urine*
chemical_list: D019187:Cadmium Compounds; D014527:Uric Acid; D006108:Graphite; D013691:Tellurium; C028337:cadmium telluride; D004298:Dopamine
keywords: Dopamine; Graphene; Quantum dot; Simultaneous detection; Uric acid