title: Role of CD56 in Normal Kidney Development and Wilms Tumorigenesis.
abstract: The cell-surface glycoprotein CD56 has three major isoforms that play important roles in cell adhesion and signaling, which may promote cell proliferation, differentiation, survival, or migration. It is an important molecule in normal kidney development and acts as a key marker in Wilms tumor stem and progenitor cells. Here, we review the structural and genetic features of the CD56 glycoprotein, and summarize its roles in the normal versus diseased metanephric blastema. We discuss areas of CD56-related research that may complement or improve existing Wilms tumor treatment strategies, including the antibody-drug conjugate lorvotuzumab mertansine that binds to CD56.
authors.affiliation: a Department of Life Sciences , Imperial College London , London , UK.
authors.forename: Li-Wei
authors.initials: LW
authors.lastname: Yap
authors.affiliation: b University College London Institute of Child Health, Cancer Section , London , UK.|c Rigshospitalet , Kobenhavn , Denmark.
authors.forename: Jesper
authors.initials: J
authors.lastname: Brok
authors.affiliation: b University College London Institute of Child Health, Cancer Section , London , UK.
authors.forename: Kathy
authors.initials: K
authors.lastname: Pritchard-Jones
mesh_terms: D000911:Antibodies, Monoclonal / Q000737:chemistry; D019002:CD56 Antigen / Q000378:metabolism / Q000502:physiology*; D002448:Cell Adhesion; D002454:Cell Differentiation; D002465:Cell Movement; D049109:Cell Proliferation; D002470:Cell Survival; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D007668:Kidney / Q000196:embryology* / Q000502:physiology; D008453:Maytansine / Q000031:analogs & derivatives / Q000737:chemistry; D011485:Protein Binding; D000072417:Protein Domains; D051496:Receptor, Fibroblast Growth Factor, Type 1 / Q000378:metabolism; D015398:Signal Transduction; D009396:Wilms Tumor / Q000235:genetics* / Q000378:metabolism*
chemical_list: D000911:Antibodies, Monoclonal; D019002:CD56 Antigen; D006023:Glycoproteins; C522918:NCAM1 protein, human; C579429:lorvotuzumab mertansine; D008453:Maytansine; C496348:FGFR1 protein, human; D051496:Receptor, Fibroblast Growth Factor, Type 1
keywords: Blastema; CD56; Kidney development; Lorvotuzumab mertansine; NCAM-1; Wilms tumor