title: Effects of sustained-release trimetazidine on chronically dysfunctional myocardium of ischemic dilated cardiomyopathy - Six months follow-up result.
abstract: BACKGROUND
  Ischemic cardiomyopathy is a growing burden in third world countries. So far, benefits of trimetazidine in this group of patients have been suggested by clinical trials mainly conducted in Europe. We evaluated the effect of trimetazidine on ischemic dilated cardiomyopathy in our population.
  
  
  RESULTS
  98 patients (aged 58.5±9.2 years), admitted with decompensated heart failure with previous history of MI and/or documentation of significant CAD with previous CAG, were chosen for the study. Patients were randomized into two groups - one provided with trimetazidine 35mg sustained released tablet, twice daily and the other with a placebo, along with other conventional medications. Patients were included if they had dilated LV (LVIDd>57mm) and left ventricular ejection fraction (LVEF) ≤40%. After 6 months, significantly higher number of patients in trimetazidine group were in NYHA class I (22% vs. 8%, p=0.03) and class II (56% vs. 34%, p=0.01); higher number of patients in placebo group were in NYHA class III class IV. Anginal episodes and use of sublingual nitrate per week were significantly lower in the trimetazidine group. Left ventricular diastolic dimension (59.7±5.2 vs. 65.1±6.1, p=0.001) was significantly different in the two groups as was the increase of LVEF (11% vs. 5.6%, p=0.001). Hospitalization for worsening heart failure was significantly lower in trimetazidine group (13 vs. 22, p=0.047).
  
  
  CONCLUSIONS
  Trimetazidine seems to be beneficial in patients with ischemic dilated cardiomyopathy in South Asian population and larger scale study with extended follow-up is needed.
authors.affiliation: National Institute of Cardiovascular Diseases (NICVD), Dhaka, Bangladesh. Electronic address: abdulmomen71@yahoo.com.
authors.forename: A
authors.initials: A
authors.lastname: Momen
authors.affiliation: Professor and Head, Department of Cardiology, National Institute of Cardiovascular Diseases (NICVD), Dhaka, Bangladesh.
authors.forename: M
authors.initials: M
authors.lastname: Ali
authors.affiliation: Assistant Professor, Cardiology, National Institute of Cardiovascular Diseases (NICVD), Dhaka, Bangladesh.
authors.forename: P K
authors.initials: PK
authors.lastname: Karmakar
authors.affiliation: Assistant Professor, Cardiology, National Institute of Cardiovascular Diseases (NICVD), Dhaka, Bangladesh.
authors.forename: M Z
authors.initials: MZ
authors.lastname: Ali
authors.affiliation: Assistant Professor, Cardiology, National Institute of Cardiovascular Diseases (NICVD), Dhaka, Bangladesh.
authors.forename: A
authors.initials: A
authors.lastname: Haque
authors.affiliation: Assistant Professor, Cardiology, National Institute of Cardiovascular Diseases (NICVD), Dhaka, Bangladesh.
authors.forename: M R
authors.initials: MR
authors.lastname: Khan
authors.affiliation: Assistant Professor, Cardiology, National Institute of Cardiovascular Diseases (NICVD), Dhaka, Bangladesh.
authors.forename: M I
authors.initials: MI
authors.lastname: Khalil
authors.affiliation: Assistant Professor, Cardiology, National Institute of Cardiovascular Diseases (NICVD), Dhaka, Bangladesh.
authors.forename: M S
authors.initials: MS
authors.lastname: Hossain
authors.affiliation: Assistant Professor, Cardiology, National Institute of Cardiovascular Diseases (NICVD), Dhaka, Bangladesh.
authors.forename: R M
authors.initials: RM
authors.lastname: Huda
authors.affiliation: Assistant Professor, Cardiology, National Institute of Cardiovascular Diseases (NICVD), Dhaka, Bangladesh.
authors.forename: M N
authors.initials: MN
authors.lastname: Goni
mesh_terms: D002311:Cardiomyopathy, Dilated / Q000188:drug therapy* / Q000503:physiopathology; D003692:Delayed-Action Preparations; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors; D016896:Treatment Outcome; D014292:Trimetazidine / Q000008:administration & dosage*; D014665:Vasodilator Agents / Q000008:administration & dosage; D016277:Ventricular Function, Left / Q000187:drug effects / Q000502:physiology*
chemical_list: D003692:Delayed-Action Preparations; D014665:Vasodilator Agents; D014292:Trimetazidine
keywords: Chronic heart failure; Ischemic cardiomyopathy; Trimetazidine