title: Two-dimensional polyaniline nanostructure to the development of microfluidic integrated flexible biosensors for biomarker detection.
abstract: In this work, we report a flexible field-effect-transistor (FET) biosensor design based on two-dimensional (2-D) polyaniline (PANI) nanostructure. The flexible biosensor devices were fabricated through a facile and inexpensive method that combines top-down and bottom-up processes. The chemically synthesized PANI nanostructure showed excellent p-type semiconductor properties as well as good compatibility with flexible design. With the 2-D PANI nanostructure being as thin as 80 nm and its extremely large surface-area-to-volume (SA/V) ratio due to the intrinsic properties of PANI chemical synthesis, the developed flexible biosensor exhibited outstanding sensing performance in detecting B-type natriuretic peptide (BNP) biomarkers, and was able to achieve high specificity (averagely 112 folds) with the limit of detection as low as 100 pg/mL. PANI nanostructure under bending condition was also investigated and showed controllable conductance changes being less than 20% with good restorability which may open up the possibility for wearable applications.
authors.affiliation: Department of Electrical and Computer Engineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
authors.forename: Pei
authors.initials: P
authors.lastname: Liu
authors.affiliation: Department of Materials Science and Engineering, The college of engineering, Carnegie Mellon University, Pittsburgh, PA, 15213, USA.
authors.forename: Yisi
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Department of BIN Fusion Technology, Chonbuk National University, Jeonju, 561-786, Korea. lsh1@jbnu.ac.kr.
authors.forename: Seung Hee
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Department of Electrical and Computer Engineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA, 15261, USA. miy16@pitt.edu.
authors.forename: Minhee
authors.initials: M
authors.lastname: Yun
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry*; D015415:Biomarkers / Q000032:analysis; D015374:Biosensing Techniques / Q000295:instrumentation*; D056656:Lab-On-A-Chip Devices; D057230:Limit of Detection; D049329:Nanostructures / Q000737:chemistry*; D020097:Natriuretic Peptide, Brain / Q000032:analysis; D013499:Surface Properties
chemical_list: D000814:Aniline Compounds; D015415:Biomarkers; C416807:polyaniline; D020097:Natriuretic Peptide, Brain
keywords: 2-D nanostructure; Biosensor; Flexible; Polyanilne