title: Lifestyle Interventions to Prevent Cardiovascular Events After Stroke and Transient Ischemic Attack: Systematic Review and Meta-Analysis.
abstract: OBJECTIVE
  Patients with a transient ischemic attack or ischemic stroke have an increased risk of subsequent cardiovascular events. The purpose of this systematic review and meta-analysis was to determine whether lifestyle interventions focusing on behaviorally modifiable risk factors with or without an exercise program are effective in terms of (1) preventing recurrent cardiovascular events, (2) reducing mortality, and (3) improving modifiable risk factors associated with cardiovascular disease in patients after a transient ischemic attack or ischemic stroke.
  
  
  METHODS
  For this systematic review and meta-analysis, we systematically searched PubMed, Embase, PsycInfo, and the Cochrane Library from the start of the database to May 7, 2015. Subgroup analyses were conducted to explore the influence of therapy-related factors.
  
  
  RESULTS
  Twenty-two randomized controlled trials were identified with a total of 2574 patients. Pooling showed a significant reduction in systolic blood pressure by the lifestyle interventions applied, compared with usual care (mean difference, -3.6 mm Hg; 95% confidence interval, -5.6 to -1.6, I2=33%). No significant effect was found on cardiovascular events, mortality, diastolic blood pressure, or cholesterol. In the subgroup analyses, the trials with cardiovascular fitness interventions, trials with an intervention that lasted longer than 4 months, and interventions that used >3 behavior change techniques were more effective in reducing systolic blood pressure.
  
  
  CONCLUSIONS
  We found that lifestyle interventions are effective in lowering systolic blood pressure. About other end points, this systematic review found no effect of lifestyle interventions on cardiovascular event rate mortality, diastolic blood pressure, or total cholesterol.
authors.affiliation: From the Department of Physical (I.A.D.), Department of Neurology (S.M.V.S., H.C.W., R.M.V.d.B.-V.), OLVG West, Amsterdam, The Netherlands; Department of Rehabilitation Medicine, Move Research Institute Amsterdam, VU Medical Center, The Netherlands (E.E.H.V.W., G.K.); and Reade Center for Rehabilitation and Rheumatology, Amsterdam, The Netherlands (G.K.).
authors.forename: Inger A
authors.initials: IA
authors.lastname: Deijle
authors.affiliation: From the Department of Physical (I.A.D.), Department of Neurology (S.M.V.S., H.C.W., R.M.V.d.B.-V.), OLVG West, Amsterdam, The Netherlands; Department of Rehabilitation Medicine, Move Research Institute Amsterdam, VU Medical Center, The Netherlands (E.E.H.V.W., G.K.); and Reade Center for Rehabilitation and Rheumatology, Amsterdam, The Netherlands (G.K.).
authors.forename: Sander M
authors.initials: SM
authors.lastname: Van Schaik
authors.affiliation: From the Department of Physical (I.A.D.), Department of Neurology (S.M.V.S., H.C.W., R.M.V.d.B.-V.), OLVG West, Amsterdam, The Netherlands; Department of Rehabilitation Medicine, Move Research Institute Amsterdam, VU Medical Center, The Netherlands (E.E.H.V.W., G.K.); and Reade Center for Rehabilitation and Rheumatology, Amsterdam, The Netherlands (G.K.).
authors.forename: Erwin E H
authors.initials: EE
authors.lastname: Van Wegen
authors.affiliation: From the Department of Physical (I.A.D.), Department of Neurology (S.M.V.S., H.C.W., R.M.V.d.B.-V.), OLVG West, Amsterdam, The Netherlands; Department of Rehabilitation Medicine, Move Research Institute Amsterdam, VU Medical Center, The Netherlands (E.E.H.V.W., G.K.); and Reade Center for Rehabilitation and Rheumatology, Amsterdam, The Netherlands (G.K.).
authors.forename: Henry C
authors.initials: HC
authors.lastname: Weinstein
authors.affiliation: From the Department of Physical (I.A.D.), Department of Neurology (S.M.V.S., H.C.W., R.M.V.d.B.-V.), OLVG West, Amsterdam, The Netherlands; Department of Rehabilitation Medicine, Move Research Institute Amsterdam, VU Medical Center, The Netherlands (E.E.H.V.W., G.K.); and Reade Center for Rehabilitation and Rheumatology, Amsterdam, The Netherlands (G.K.).
authors.forename: Gert
authors.initials: G
authors.lastname: Kwakkel
authors.affiliation: From the Department of Physical (I.A.D.), Department of Neurology (S.M.V.S., H.C.W., R.M.V.d.B.-V.), OLVG West, Amsterdam, The Netherlands; Department of Rehabilitation Medicine, Move Research Institute Amsterdam, VU Medical Center, The Netherlands (E.E.H.V.W., G.K.); and Reade Center for Rehabilitation and Rheumatology, Amsterdam, The Netherlands (G.K.). r.vandenberg-vos@olvg.nl.
authors.forename: Renske M
authors.initials: RM
authors.lastname: Van den Berg-Vos
mesh_terms: D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000517:prevention & control*; D015444:Exercise / Q000502:physiology; D006801:Humans; D002546:Ischemic Attack, Transient / Q000453:epidemiology / Q000628:therapy*; D016032:Randomized Controlled Trials as Topic / Q000379:methods; D012307:Risk Factors; D040242:Risk Reduction Behavior; D055502:Secondary Prevention / Q000379:methods*; D020521:Stroke / Q000453:epidemiology / Q000628:therapy*
keywords: life style; secondary prevention; stroke