title: ‎ Association Between Neuregulin-1 Gene Variant ‎‎(rs2439272) and Schizophrenia and Its Negative ‎Symptoms in an Iranian Population.
abstract: Objective:Although the etiology of schizophrenia is unknown, it has a significant genetic component. ‎A number of studies have indicated that neuregulin-1 (NRG1) gene may play a role in the ‎pathogenesis of schizophrenia. In this study, we examined whether the rs2439272 of NRG1 ‎is associated with schizophrenia and its negative symptoms in an Iranian population.‎Method:Rs2439272 was genotyped in 469 participants including 276 unrelated patients with schizophrenia and 193 healthy controls. The association of genetic risk with negative ‎symptoms (by using panss) was examined in the total, male and female samples. COCAPHASE and ‎CLUMP22 programs were used to compare the allele and genotype frequencies, and ‎general linear regression was used to analyze the quantitative dependent variables by the ‎selected variant.‎Results:In this study, it was revealed that the G allele of rs2439272 might be an allele with the ‎increased risk of developing schizophrenia, especially in the male participants. In addition, ‎significant differences were found between the G allele and GG genotype frequencies, and negative symptoms in the total and male participants.‎Conclusion:Our results supported the association between rs2439272 in NRG1 gene and risk of ‎schizophrenia and its negative symptoms in an Iranian population. ‎.
authors.affiliation: Neuroscience and Neurology Research Center, Qom University of Medical Sciences, Qom, ‎Iran.; Department of Neuroscience, School of Advanced Technologies in Medicine, Iran ‎University of Medical Sciences, Tehran, Iran‎.; Health and Religion Research Center, Qom University of Medical Sciences, Qom, Iran.
authors.forename: Sadegh
authors.initials: S
authors.lastname: Yoosefee
authors.affiliation: ‎Department of Adult Psychiatry, Roozbeh Hospital, School of Medicine, Tehran University of ‎Medical Sciences, Tehran, Iran.; ‎Department of Genomic Psychiatry and Behavioral Genomics, Roozbeh ‎Psychiatry Hospital, School of ‎Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Esmaeil
authors.initials: E
authors.lastname: Shahsavand Ananloo
authors.affiliation: Department of Neuroscience, School of Advanced Technologies in Medicine, Iran ‎University of Medical Sciences, Tehran, Iran‎.
authors.forename: Mohammad-Taghi
authors.initials: MT
authors.lastname: Joghataei
authors.affiliation: Molecular Medicine Group, Pasteur Institute of Iran, Tehran, Iran.
authors.forename: Morteza
authors.initials: M
authors.lastname: Karimipour
authors.affiliation: Department of Neuroscience and Addiction Studies, School of Advanced Technologies in Medicine, Tehran ‎University of Medical ‎Sciences, Tehran, Iran.
authors.forename: Mahmoudreza
authors.initials: M
authors.lastname: Hadjighassem
authors.affiliation: Department of Neuroscience and Addiction Studies, School of Advanced Technologies in Medicine, Tehran ‎University of Medical ‎Sciences, Tehran, Iran.
authors.forename: Hoorie
authors.initials: H
authors.lastname: Mohaghghegh
authors.affiliation: Department of Child and Adolescent Psychiatry, Roozbeh Hospital, School of Medicine, ‎Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Tehrani-Doost
authors.affiliation: Molecular Medicine Group, Pasteur Institute of Iran, Tehran, Iran.
authors.forename: Amir-Abbas
authors.initials: AA
authors.lastname: Rahimi
authors.affiliation: Department of Genetics & Genomics, Boston University School of Medicine, Boston, MA, ‎United States.
authors.forename: Hamid
authors.initials: H
authors.lastname: Mostafavi Abdolmaleky
authors.affiliation: ‎Department of Adult Psychiatry, Roozbeh Hospital, School of Medicine, Tehran University of ‎Medical Sciences, Tehran, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Hatami
keywords: Negative Symptoms; Neuregulin-1 (NRG1); Positive and Negative Syndrome Scale ‎‎ (PANSS); Schizophrenia; Single Nucleotide Polymorphism (SNP)