title: Dipeptide-Based Chiral Tertiary Amine-Catalyzed Asymmetric Conjugate Addition Reactions of 5H-Thiazol/Oxazol-4-Ones.
abstract: Highly enantio- and chemo-selective 1,4-conjugate addition process of 5H-thiazol-4-ones with maleimides or 1,4-naphthoquinones, and 5H-oxazol-4-ones with maleimides were performed under a dipeptide-based tertiary amine (DP-UAA) catalyst. A series of valuable N,S- and N,O-containing heterocyclic compounds with excellent enantio- and disastereo-selectivities (up to >99% ee, > 20:1 dr) were attained.
authors.affiliation: Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, Henan University , Kaifeng, Henan 475004, P. R. China.
authors.forename: Jiangtao
authors.initials: J
authors.lastname: Li
authors.affiliation: Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, Henan University , Kaifeng, Henan 475004, P. R. China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Qiu
authors.affiliation: Division of Chemistry and Biological Chemistry, Nanyang Technological University , 21 Nanyang Link, 637371, Singapore.
authors.forename: Xinyi
authors.initials: X
authors.lastname: Ye
authors.affiliation: Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, Henan University , Kaifeng, Henan 475004, P. R. China.
authors.forename: Bo
authors.initials: B
authors.lastname: Zhu
authors.affiliation: Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, Henan University , Kaifeng, Henan 475004, P. R. China.
authors.forename: Hongjun
authors.initials: H
authors.lastname: Liu
authors.affiliation: Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, Henan University , Kaifeng, Henan 475004, P. R. China.
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Jiang