title: Parallel reductions of IgE and exhaled nitric oxide after optimized anti-inflammatory asthma treatment.
abstract: Immunoglobulin E (IgE) is crucial for the development of airway inflammation in atopic asthma, and inhibition of IgE using monoclonal antibodies is now part of asthma therapy. However, the impact of ordinary anti-inflammatory treatment on IgE is unclear. The aim of this study was to investigate if optimization of treatment with inhaled corticosteroid (ICS) and leukotriene-receptor antagonist (LTRA) according to symptoms or exhaled nitric oxide (FENO) levels over a one-year period affects IgE concentrations. Altogether, 158 relatively well-controlled but multi-sensitized asthmatics (age 18-65 years), with ongoing ICS treatment at baseline, were included in this post hoc analysis of data from a randomized, controlled trial on FENO-guided asthma therapy. Asthma control and quality of life (Juniper ACQ and mAQLQ), FENO, and serum IgE were measured at baseline and after one year. Concentrations of IgE antibodies to six common perennial aeroallergens were summed up (perennial IgE). We found that perennial and total IgE decreased by 10.2% and 16.0% (P< .001 both comparisons). This was not related to allergen exposure, whereas the total use of ICS and LTRA during the year correlated with the reduction in perennial IgE (P= .030 andP= .013). The decrease in perennial and total IgE correlated significantly with the reduction in FENO (P< .003 andP< .001), and with improvements in ACQ and mAQLQ scores (P< 0.05, all comparisons). We conclude that one year of optimization of treatment with ICS and LTRA in patients with persistent atopic asthma resulted in significant decreases in total IgE and IgE antibodies; these decreases correlated with a reduction in FENO and improvements in asthma control and quality of life. Thus, IgE is reduced by ordinary asthma controller medications and the effect on IgE seems to be clinically important.
authors.affiliation: Department of NeurobiologyCare Sciences and Society, Karolinska InstitutetStockholmSweden; Centre for Allergy Research, Karolinska InstitutetStockholmSweden.
authors.forename: Jörgen
authors.initials: J
authors.lastname: Syk
authors.affiliation: Department of Medical Sciences Clinical Physiology, Uppsala University Uppsala Sweden.
authors.forename: Andrei
authors.initials: A
authors.lastname: Malinovschi
authors.affiliation: Department of Women's and Children's Health Uppsala University Uppsala Sweden.
authors.forename: Magnus P
authors.initials: MP
authors.lastname: Borres
authors.affiliation: Department of Neurobiology Care Sciences and Society, Karolinska Institutet Stockholm Sweden.
authors.forename: Anna-Lena
authors.initials: AL
authors.lastname: Undén
authors.affiliation: Department of NeurobiologyCare Sciences and Society, Karolinska InstitutetStockholmSweden; Stress Research InstituteStockholm UniversityStockholmSweden.
authors.forename: Anna
authors.initials: A
authors.lastname: Andreasson
authors.affiliation: Stress Research InstituteStockholm UniversityStockholmSweden; Department of Clinical NeuroscienceKarolinska InstitutetStockholmSweden.
authors.forename: Mats
authors.initials: M
authors.lastname: Lekander
authors.affiliation: Department of Women's and Children's Health Uppsala University Uppsala Sweden.
authors.forename: Kjell
authors.initials: K
authors.lastname: Alving
mesh_terms: D018927:Anti-Asthmatic Agents / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy*; D001944:Breath Tests; D045853:Exhalation; D005500:Follow-Up Studies; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology / Q000378:metabolism*; D009569:Nitric Oxide / Q000032:analysis*; D011788:Quality of Life
chemical_list: D018927:Anti-Asthmatic Agents; D009569:Nitric Oxide; D007073:Immunoglobulin E
keywords: Asthma; FENO; asthma control; atopy; breath test; corticosteroid; immunoglobulin E; leukotriene‐receptor antagonist; quality of life