title: Comparison of Biocompatibility of Cemented vs. Cementless Hip Joint Endoprostheses Based on Postoperative Evaluation of Proinflammatory Cytokine Levels.
abstract: BACKGROUND The yearly increase in the number of procedures involving implantation of hip joint endoprostheses forces prosthetics manufacturers to search for biologically neutral implants. The goal of this study was to assess the concentration of Interleukin-6 (IL-6) and its correlation with C-reactive protein (CRP), depending on the type of hip joint endoprosthesis (cemented or cementless endoprosthesis) in order to determine implant biotolerance during the early postoperative period. MATERIAL AND METHODS The sample comprised 200 patients [mean age=64 (31-81) years] with coxarthrosis. All patients underwent hip joint arthroplasty using a cemented or cementless endoprosthesis. Blood samples were collected 3 times: before the procedure, on the first day after the procedure, and after 6 weeks. IL-6 and CRP levels were assayed using immunoenzymatic methods. The results were subjected to statistical analysis using the Shapiro-Wilk test. RESULTS On the 1st day after the procedure, CRP and IL-6 concentration increased rapidly after implantation of both cemented and cementless endoprostheses. At 6 weeks postoperatively, the CRP value remained at a similar level in patients after cemented arthroplasty and was almost 2-fold lower in patients who underwent cementless arthroplasty. The IL-6 value returned to the baseline level in patients after cementless arthroplasty and showed an ongoing increasing tendency in patients after cemented arthroplasty. CONCLUSIONS 1. The measurement of C-reactive protein and Interleukin-6 is a high-sensitivity test, assessing implant biotolerance. 2. The implantation of a cemented endoprosthesis induces a higher increase in the level of proinflammatory cytokines as compared with a cementless endoprosthesis. 3. For a complete assessment of both early and later body responses to implantation and the related surgical procedure, further studies using available approaches and tools are recommended.
authors.affiliation: Department of Orthopedic Surgery, Luxmed Hospital, Warsaw, Poland.
authors.forename: Jan
authors.initials: J
authors.lastname: Szypuła
authors.affiliation: Department of Rehabilitation, University of Physical Education, Warsaw, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Cabak
authors.affiliation: Jan Kochanowski University, Kielce, Poland.|University of Computer Science and Skills, Łódź, Poland.
authors.forename: Marek
authors.initials: M
authors.lastname: Kiljański
authors.affiliation: Department of Rehabilitation, Physiotherapy Division, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Dariusz
authors.initials: D
authors.lastname: Boguszewski
authors.affiliation: College of Physiotherapy, Wrocław, Poland.
authors.forename: Wiesław
authors.initials: W
authors.lastname: Tomaszewski
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019644:Arthroplasty, Replacement, Hip / Q000379:methods*; D001843:Bone Cements / Q000627:therapeutic use*; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D006622:Hip Prosthesis; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D015207:Osteoarthritis, Hip / Q000378:metabolism / Q000534:rehabilitation / Q000601:surgery*; D011184:Postoperative Period; D011474:Prosthesis Design; D016896:Treatment Outcome
chemical_list: D001843:Bone Cements; C508600:IL6 protein, human; D015850:Interleukin-6; D002097:C-Reactive Protein