title: Effects of different surfactant administrations on cerebral autoregulation in preterm infants with respiratory distress syndrome.
abstract: To treat respiratory distress syndrome, surfactant is currently delivered via less invasive surfactant administration (LISA) or INtubation SURfactant Extubation (INSURE). The aim of this study was to compare the effect of the two delivery methods of surfactant on cerebral autoregulation. Near infrared spectroscopy monitoring was carried out to detect cerebral oxygen saturation (ScO2), and the mean arterial blood pressure (MABP) was simultaneously recorded. Of 44 preterm infants included, the surfactant was administrated to 22 via LISA and 22 via INSURE. The clinical characteristics, treatments and outcomes of the infants showed no significant differences between the two groups. The correlation coefficient of ScO2and MABP (rScO2-MABP) 5 min before administration was similar in the two groups. During surfactant administration, rScO2-MABPincreased in both groups (0.44±0.10 to 0.54±0.12 in LISA, 0.45±0.11 to 0.69±0.09 in INSURE). In the first and second 5 min after instillation, rScO2-MABPwas not significantly different from baseline in the LISA group, but increased in the first 5 min after instillation (0.59±0.13, P=0.000 compared with the baseline in the same group) and recovered in the second 5 min after instillation (0.48±0.10, P=0.321) in the INSURE group. There were significant differences in the change rates of rScO2-MABPbetween the two groups during and after surfactant administration. Our results suggest that cerebral autoregulation may be affected transiently by surfactant administration. The effect duration of LISA is shorter than that of INSURE (<5 min in LISA vs. 5-10 min in INSURE).
authors.affiliation: Department of Neonatology, Guangzhou Women and Children's Medical Center, Guangzhou, 510010, China.
authors.forename: Xu-Fang
authors.initials: XF
authors.lastname: Li
authors.affiliation: Department of Neonatology, Guangzhou Women and Children's Medical Center, Guangzhou, 510010, China.
authors.forename: Ting-Ting
authors.initials: TT
authors.lastname: Cheng
authors.affiliation: Department of Neonatology, Guangzhou Women and Children's Medical Center, Guangzhou, 510010, China.
authors.forename: Rui-Lian
authors.initials: RL
authors.lastname: Guan
authors.affiliation: Department of Neonatology, Guangzhou Women and Children's Medical Center, Guangzhou, 510010, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Liang
authors.affiliation: Department of Neonatology, Guangzhou Women and Children's Medical Center, Guangzhou, 510010, China.
authors.forename: Wei-Neng
authors.initials: WN
authors.lastname: Lu
authors.affiliation: Department of Neonatology, Guangzhou Women and Children's Medical Center, Guangzhou, 510010, China.
authors.forename: Jing-Hua
authors.initials: JH
authors.lastname: Zhang
authors.affiliation: Department of Neonatology, Guangzhou Women and Children's Medical Center, Guangzhou, 510010, China.
authors.forename: Mei-Yi
authors.initials: MY
authors.lastname: Liu
authors.affiliation: Department of Neonatology, Guangzhou Women and Children's Medical Center, Guangzhou, 510010, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Yu
authors.affiliation: Department of Neonatology, Guangzhou Women and Children's Medical Center, Guangzhou, 510010, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Liang
authors.affiliation: Department of Neonatology, Guangzhou Women and Children's Medical Center, Guangzhou, 510010, China.
authors.forename: Li
authors.initials: L
authors.lastname: Sun
authors.affiliation: Department of Neonatology, Guangzhou Women and Children's Medical Center, Guangzhou, 510010, China. zhliande@qq.com.
authors.forename: Lian
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000281:Administration, Intranasal / Q000009:adverse effects*; D001921:Brain / Q000378:metabolism*; D005260:Female; D006706:Homeostasis; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007440:Intubation / Q000009:adverse effects*; D008297:Male; D010101:Oxygen Consumption; D011663:Pulmonary Surfactants / Q000008:administration & dosage* / Q000627:therapeutic use; D012127:Respiratory Distress Syndrome, Newborn / Q000188:drug therapy* / Q000628:therapy
chemical_list: D011663:Pulmonary Surfactants
keywords: cerebral autoregulation; preterm infant; pulmonary surfactant; respiratory distress syndrome; surfactant