title: Galectin-3 Expression in Benign and Malignant Skin Diseases With Epidermal Hyperplasia.
abstract: Galectin-3 has been suggested relative to tumor genesis, progression, and metastasis in basal cell carcinoma and squamous cell carcinoma that are the most common skin cancers characterized by malignant epidermal proliferation. In this study, we evaluated galectin-3 expression in seborrheic keratosis, keratoacanthoma, and infectious diseases including verruca vulgaris, condyloma acuminatum, and chromoblastomycosis that are pathologically featured by benign epidermal proliferation. Galectin-3 expression was shown by immunohistochemical staining and quantified using the Image Pro Plus V6.0. We found that galectin-3 distributed evenly in normal skin around the body decreased significantly in all selected diseases compared with healthy controls, but it was comparable among each disease. These findings imply that galectin-3 do not differentiate between benign and malignant proliferation of keratinocytes.
authors.affiliation: Department of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
authors.forename: Ze-Xin
authors.initials: ZX
authors.lastname: Jiang
authors.forename: Guo-Zhen
authors.initials: GZ
authors.lastname: Tan
authors.forename: Zhen-Rui
authors.initials: ZR
authors.lastname: Shi
authors.forename: Yu-Ping
authors.initials: YP
authors.lastname: Zhang
authors.forename: Yan-Fang
authors.initials: YF
authors.lastname: Han
authors.forename: Liangchun
authors.initials: L
authors.lastname: Wang
mesh_terms: D015415:Biomarkers / Q000032:analysis*; D001798:Blood Proteins; D004817:Epidermis / Q000378:metabolism / Q000473:pathology; D037502:Galectin 3 / Q000032:analysis / Q000096:biosynthesis*; D037161:Galectins; D006801:Humans; D006965:Hyperplasia / Q000378:metabolism / Q000473:pathology; D015603:Keratinocytes / Q000378:metabolism / Q000473:pathology; D012871:Skin Diseases / Q000378:metabolism* / Q000473:pathology
chemical_list: D015415:Biomarkers; D001798:Blood Proteins; D037502:Galectin 3; D037161:Galectins; C428445:LGALS3 protein, human