title: Culprit or Bystander? The Role of the Fallopian Tube in "Ovarian" High-Grade Serous Carcinoma.
abstract: The concurrence of intraepithelial high-grade neoplasia in the fallopian tube with metastatic implants has been taken as evidence of a tubal origin for high-grade serous pelvic carcinomas. In the current issue, Eckert and colleagues perform detailed genomic phylogenetic analyses and demonstrate that some cases of high-grade serous intraepithelial tubal neoplasia are metastatic implants and not precursor lesions. Cancer Discov; 6(12); 1309-11. ©2016 AACR.See related article by Eckert and colleagues, p. 1342.
authors.affiliation: Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington. swishere@uw.edu.
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Swisher
authors.affiliation: Department of Pathology, University of Washington, Seattle, Washington.
authors.forename: Rochelle L
authors.initials: RL
authors.lastname: Garcia
authors.affiliation: Department of Pathology, University of Washington, Seattle, Washington.
authors.forename: Mark R
authors.initials: MR
authors.lastname: Kilgore
authors.affiliation: Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington.
authors.forename: Barbara M
authors.initials: BM
authors.lastname: Norquist
mesh_terms: D000818:Animals; D002278:Carcinoma in Situ; D018284:Cystadenocarcinoma, Serous; D005185:Fallopian Tube Neoplasms; D005187:Fallopian Tubes; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms; D010802:Phylogeny