title: Pediatric intracranial primary anaplastic ganglioglioma.
abstract: BACKGROUND
  Primary intracranial anaplastic gangliogliomas are rare tumors in the pediatric patient group. Most of them present with symptoms of elevated pressure or symptomatic epilepsy. Extraaxial location is far more common than axial location. On MRI examination, they mimic pilocytic astrocytomas. The outcome after surgery depends mainly on the possible amount of surgical resection, and oncological therapy is necessary to prevent recurrence of the disease.
  
  
  METHODS
  An 11-year-old boy presented with headache and double vision due to obstructive hydrocephalus. MRI of the brain revealed an axial partially contrast enhancing lesion in the quadrigeminal plate extending from the cerebellum to the pineal gland and causing hydrocephalus. Subtotal removal of the lesion was performed, and the diagnosis of an anaplastic ganglioglioma was established and confirmed by the reference center. At the latest follow up (3 months), the boy is without any neurological symptoms and scheduled for radiation therapy as well as chemotherapy.
authors.affiliation: Neurosurgical Department, Helios Klinik Hildesheim, 31135, Hildesheim, Germany. Wolf.Luedemann@helios-kliniken.de.
authors.forename: Wolf
authors.initials: W
authors.lastname: Lüdemann
authors.affiliation: Department of Neuropathology, Hannover Medical School, Hannover, Germany.
authors.forename: Rouzbeh
authors.initials: R
authors.lastname: Banan
authors.affiliation: Department of Neuropathology, Hannover Medical School, Hannover, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Hartmann
authors.affiliation: International Neuroscience Institute, Rudolf Pichlmayrstr. 4, 30625, Hannover, Germany.
authors.forename: Helmut
authors.initials: H
authors.lastname: Bertalanffy
authors.affiliation: International Neuroscience Institute, Rudolf Pichlmayrstr. 4, 30625, Hannover, Germany.
authors.forename: Concezio
authors.initials: C
authors.lastname: Di Rocco
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery; D002648:Child; D018303:Ganglioglioma / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery; D006801:Humans; D007211:Indoles / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D008297:Male; D013449:Sulfonamides / Q000627:therapeutic use; D000077484:Vemurafenib
chemical_list: D000970:Antineoplastic Agents; D007211:Indoles; D013449:Sulfonamides; D000077484:Vemurafenib
keywords: Brain; Child; Intracranial; Magnetic resonance imaging; surgical treatment; Primary anaplastic ganglioglioma