title: Copper(II)-Thymine Coordination Polymer Nanoribbons as Potential Oligonucleotide Nanocarriers.
abstract: The direct reaction between copper nitrate, thymine-1-acetic acid, and 4,4'-bipyridine in water leads to the formation of a blue colloid comprising uniform crystalline nanoribbons (length >1 μm; width ca. 150-185 nm; diameter ca. 15-60 nm) of a coordination polymer. The polymer displays a thymine-based structure freely available for supramolecular interactions. These nanostructures show significant selective interaction with single-stranded oligonucleotides based on adenine. Remarkably, they present low cell toxicity in three cell lines-despite the copper(II) content-and can be used as nanocarriers of oligonucleotides. These results suggest the potential of these types of nanostructures in several biological applications.
authors.affiliation: Departamento de Química Inorgánica and Institute for Advanced Research in Chemical Sciences at UAM (IADCHEM), Universidad Autónoma de Madrid, 28049, Madrid, Spain.
authors.forename: Verónica G
authors.initials: VG
authors.lastname: Vegas
authors.affiliation: Instituto Madrileño de Estudios Avanzados en Nanociencia (IMDEA Nanociencia), Cantoblanco, 28049, Madrid, Spain.
authors.forename: Romina
authors.initials: R
authors.lastname: Lorca
authors.affiliation: Instituto Madrileño de Estudios Avanzados en Nanociencia (IMDEA Nanociencia), Cantoblanco, 28049, Madrid, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Latorre
authors.affiliation: Departamento de Química Inorgánica and Institute for Advanced Research in Chemical Sciences at UAM (IADCHEM), Universidad Autónoma de Madrid, 28049, Madrid, Spain.
authors.forename: Khaled
authors.initials: K
authors.lastname: Hassanein
authors.affiliation: Departamento de Química Inorgánica, Instituto de Ciencia Molecular (ICMol), Parque Científico, Universidad de Valencia, Catedrático José Beltrán, 2, 46980, Paterna Valencia, Spain.
authors.forename: Carlos J
authors.initials: CJ
authors.lastname: Gómez-García
authors.affiliation: Departamento de Química Inorgánica, Universidad del País Vasco, UPV/EHU, Apartado 644, 48080, Bilbao, Spain.
authors.forename: Oscar
authors.initials: O
authors.lastname: Castillo
authors.affiliation: Instituto Madrileño de Estudios Avanzados en Nanociencia (IMDEA Nanociencia), Cantoblanco, 28049, Madrid, Spain.|Nanobiotecnología (IMDEA-Nanociencia), Unidad Asociada al Centro Nacional de Biotecnología (CSIC), 28049, Madrid, Spain.
authors.forename: Álvaro
authors.initials: Á
authors.lastname: Somoza
authors.affiliation: Departamento de Química Inorgánica and Institute for Advanced Research in Chemical Sciences at UAM (IADCHEM), Universidad Autónoma de Madrid, 28049, Madrid, Spain.|Instituto Madrileño de Estudios Avanzados en Nanociencia (IMDEA Nanociencia), Cantoblanco, 28049, Madrid, Spain.
authors.forename: Félix
authors.initials: F
authors.lastname: Zamora
authors.affiliation: Departamento de Química Inorgánica and Institute for Advanced Research in Chemical Sciences at UAM (IADCHEM), Universidad Autónoma de Madrid, 28049, Madrid, Spain.
authors.forename: Pilar
authors.initials: P
authors.lastname: Amo-Ochoa
keywords: coordination polymers; nanocarriers; nanoribbons; oligonucleotides