title: The association of uric acid with leukoaraiosis.
abstract: Objective To explore the possible correlation between uric acid levels and leukoaraiosis (LA). Methods This cross-sectional study enrolled patients who presented with some neurological discomfort (e.g. dizziness, headache, mild cognitive impairment). Potential demographic and clinical risk factors associated with LA, including sex, age, hypertension, diabetes mellitus, smoking, alcohol consumption, dyslipidaemia, plasma fibrinogen, D-dimer, uric acid, and homocysteine, were investigated using univariate and multivariate logistic regression analyses. Results A total of 268 patients were enrolled in the study and divided into the LA group ( n = 164) and the non-LA group ( n = 104). Compared with the non-LA group, uric acid was significantly higher in the LA group (mean ± SD: 356.49 ± 121.85 µmol/l versus 289.96 ± 102.98 µmol/l). Multivariate logistic regression analyses showed that uric acid was an independent risk factor for LA (odds ratio 1.285; 95% confidence interval 1.062, 1.556). Conclusion Hyperuricaemia was an independent risk factor for leukoaraiosis in Chinese patients.
authors.affiliation: 1 Department of Neurology, Quanzhou First Hospital, Quanzhou, Fujian Province, China.
authors.forename: Jun-Jing
authors.initials: JJ
authors.lastname: Li
authors.affiliation: 2 Department of Neurology, Hospital of Jinjiang City, Jinjiang, Fujian Province, China.
authors.forename: Yin-Hui
authors.initials: YH
authors.lastname: Huang
authors.affiliation: 2 Department of Neurology, Hospital of Jinjiang City, Jinjiang, Fujian Province, China.
authors.forename: You-Yu
authors.initials: YY
authors.lastname: Lin
authors.affiliation: 3 Department of Neurology, Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, China.
authors.forename: Mi-Mi
authors.initials: MM
authors.lastname: Li
authors.affiliation: 3 Department of Neurology, Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, China.
authors.forename: Ya-Fang
authors.initials: YF
authors.lastname: Chen
authors.affiliation: 2 Department of Neurology, Hospital of Jinjiang City, Jinjiang, Fujian Province, China.|3 Department of Neurology, Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, China.
authors.forename: Ruo-Wei
authors.initials: RW
authors.lastname: Cai
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking / Q000503:physiopathology; D044466:Asian People; D060825:Cognitive Dysfunction / Q000503:physiopathology; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000503:physiopathology; D004244:Dizziness / Q000503:physiopathology; D050171:Dyslipidemias / Q000503:physiopathology; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D006261:Headache / Q000503:physiopathology; D006710:Homocysteine / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D033461:Hyperuricemia / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000208:ethnology; D049292:Leukoaraiosis / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012307:Risk Factors; D012907:Smoking / Q000503:physiopathology; D014527:Uric Acid / Q000097:blood*
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D; D006710:Homocysteine; D014527:Uric Acid; D005340:Fibrinogen
keywords: Uric acid; leukoaraiosis