title: Deazaguanine derivatives, examples of crosstalk between RNA and DNA modification pathways.
abstract: Seven-deazapurine modifications were thought to be highly specific of tRNAs, but have now been discovered in DNA of phages and of phylogenetically diverse bacteria, illustrating the plasticity of these modification pathways. The intermediate 7-cyano-7-deazaguanine (preQ0) is a shared precursor in the pathways leading to the insetion of 7-deazapurine derivatives in both tRNA and DNA. It is also used as an intermediate in the synthesis of secondary metabolites such as toyocamacin. The presence of 7-deazapurine in DNA is proposed to be a protection mechanism against endonucleases. This makes preQ0a metabolite of underappreaciated but central importance.
authors.affiliation: a Department of Microbiology and Cell Science , University of Florida , Gainesville , FL , USA.
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Hutinet
authors.affiliation: b Department of Chemistry and Biochemistry , San Diego State University , San Diego , CA , USA.
authors.forename: Manal A
authors.identifier: 0000-0003-1334-1763
authors.initials: MA
authors.lastname: Swarjo
authors.affiliation: a Department of Microbiology and Cell Science , University of Florida , Gainesville , FL , USA.
authors.forename: Valérie
authors.identifier: 0000-0002-9955-3785
authors.initials: V
authors.lastname: de Crécy-Lagard
mesh_terms: D001105:Archaea / Q000235:genetics / Q000378:metabolism; D001419:Bacteria / Q000235:genetics / Q000378:metabolism; D001435:Bacteriophages / Q000235:genetics / Q000378:metabolism; D004247:DNA / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D056890:Eukaryota / Q000235:genetics / Q000378:metabolism; D022761:Gene Transfer, Horizontal; D006147:Guanine / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism; D053858:Metabolic Networks and Pathways; D009704:Nucleoside Q / Q000737:chemistry / Q000378:metabolism; D012313:RNA / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D012343:RNA, Transfer / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
chemical_list: D009704:Nucleoside Q; D006147:Guanine; D012313:RNA; D004247:DNA; D012343:RNA, Transfer
keywords: DNA; Deazaguanine modifications; tRNA