title: [Correlations between serum 25-hydroxyvitamin D and cytokines in patients newly diagnosed with systemic lupus erythematosus].
abstract: Objective To investigate the correlations between serum 25-hydroxyvitamin D (25-OH-VitD) and serum cytokines of interferon (IFN)-α2, interleukin(IL)-6, IL-10, and IL-17A in Chinese Han patients newly diagnosed with systemic lupus erythematosus (SLE). Methods This study recruited 86 Chinese patients newly diagnosed with SLE and 73 healthy volunteers. The serum 25-OH-VitD was detected using ELISA. The serum levels of IFN-α2, IL-6, IL-10 and IL-17A were detected using Luminex liquichip. The associations between serum 25-OH-VitD and serum cytokines, clinical manifestations and laboratory findings were analyzed using Spearman linear correlation analysis. Results The serum 25-OH-VitD was significantly lower in SLE patients than in healthy controls. The serum 25-OH-VitD was positively correlated with serum C3, negatively correlated with serum IL-17A and 24 hour urine protein excretion, but not obviously correlated with serum IFN-α2, IL-6 and IL-10. Conclusion The serum 25-OH-VitD decreases in Chinese patients newly diagnosed with SLE and it is negatively correlated with serum IL-17A.
authors.affiliation: Department of Rheumatology, Sichuan Academy of Medical Science, Sichuan Provincial People's Hospital, Chengdu 610072, China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Su
authors.affiliation: Department of Rheumatology, Sichuan Academy of Medical Science, Sichuan Provincial People's Hospital, Chengdu 610072, China. *Corresponding author, E-mail: zhujingys@sina.com.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Clinical Laboratory, Sichuan Academy of Medical Science, Sichuan Provincial People's Hospital, Chengdu 610072, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Dong
authors.affiliation: Department of Rheumatology, Sichuan Academy of Medical Science, Sichuan Provincial People's Hospital, Chengdu 610072, China.
authors.forename: Li
authors.initials: L
authors.lastname: Long
authors.affiliation: Department of Rheumatology, Sichuan Academy of Medical Science, Sichuan Provincial People's Hospital, Chengdu 610072, China.
authors.forename: Wubin
authors.initials: W
authors.lastname: Long
authors.affiliation: Department of Rheumatology, Sichuan Academy of Medical Science, Sichuan Provincial People's Hospital, Chengdu 610072, China.
authors.forename: Xixi
authors.initials: X
authors.lastname: Chen
mesh_terms: D000328:Adult; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D016898:Interferon-alpha / Q000097:blood; D016753:Interleukin-10 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000175:diagnosis*; D008297:Male; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D055815:Young Adult
chemical_list: D016207:Cytokines; C508609:IL10 protein, human; D016898:Interferon-alpha; D015850:Interleukin-6; D016753:Interleukin-10; D014807:Vitamin D; C104450:25-hydroxyvitamin D