title: Effects of propofol and sevoflurane on perioperative immune response in patients undergoing laparoscopic radical hysterectomy for cervical cancer.
abstract: The aim of this study is to compare the effects of propofol and sevoflurane anesthesia on perioperative immune response in patients undergoing laparoscopic radical hysterectomy for cervical cancer.Sixty patients with cervical cancer scheduled for elective laparoscopic radical hysterectomy under general anesthesia were randomized into 2 groups. TIVA group received propofol induction and maintenance and SEVO group received sevoflurane induction and maintenance. Blood samples were collected at 30 min before induction (T0); the end of the operation (T1); and 24 h (T2), 48 h (T3), and 72 h (T4) after operation. The T lymphocyte subsets (including CD3+ cells, CD4+ cells, and CD8+ cells) and CD4+/CD8+ ratio, natural killer (NK) cells, and B lymphocytes were analyzed by flow cytometry.After surgery, all immunological indicators except CD8+ cells were significantly decreased in both groups compared to basal levels in T0, and the counts of CD3+ cells, CD4+ cells, NK cells, and the CD4+/CD8+ ratios were significantly lower in the SEVO groups than that in the TIVA group. However, the numbers of B cells were comparable at all the time points between 2 groups.Laparoscopic radical hysterectomy for cervical cancer is associated with postoperative lymphopenia. In terms of protecting circulating lymphocytes, propofol is superior to sevoflurane.
authors.affiliation: Department of Anesthesiology, Xuzhou Central Hospital, The Affiliated Xuzhou Hospital of Medical College of Southeast University, Xuzhou, Jiangsu Department of Anesthesiology, Affiliated Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Department of Anesthesiology, Xuzhou Women and Children's Health Care Hospital, Xuzhou, Jiangsu, China.
authors.forename: Songtao
authors.initials: S
authors.lastname: Liu
authors.forename: Xinyu
authors.initials: X
authors.lastname: Gu
authors.forename: Lijiao
authors.initials: L
authors.lastname: Zhu
authors.forename: Guannan
authors.initials: G
authors.lastname: Wu
authors.forename: Hai
authors.initials: H
authors.lastname: Zhou
authors.forename: Yan
authors.initials: Y
authors.lastname: Song
authors.forename: Congyou
authors.initials: C
authors.lastname: Wu
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000601:surgery; D018685:Anesthetics, Inhalation / Q000008:administration & dosage; D018686:Anesthetics, Intravenous / Q000008:administration & dosage; D016516:CD4-CD8 Ratio; D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000601:surgery; D005260:Female; D006801:Humans; D007044:Hysterectomy; D010535:Laparoscopy; D008738:Methyl Ethers / Q000008:administration & dosage; D008875:Middle Aged; D015742:Propofol / Q000008:administration & dosage; D000077149:Sevoflurane; D016176:T-Lymphocyte Subsets; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000097:blood / Q000601:surgery*
chemical_list: D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D008738:Methyl Ethers; D000077149:Sevoflurane; D015742:Propofol