title: Drugging ACAT1 for Cancer Therapy.
abstract: In this issue, Fan et al. (2016) show that oncogenic tyrosine kinases can promote glycolysis by phosphorylating and stabilizing the tetrameric form of mitochondrial acetyl-coA acetyltransferase 1 (ACAT1). The authors further identify a small molecule ACAT1 inhibitor that displays anti-cancer effects.
authors.affiliation: Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
authors.forename: Javier
authors.initials: J
authors.lastname: Garcia-Bermudez
authors.affiliation: Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA. Electronic address: kbirsoy@rockefeller.edu.
authors.forename: Kivanç
authors.initials: K
authors.lastname: Birsoy
mesh_terms: D000101:Acetyl-CoA C-Acetyltransferase; D006019:Glycolysis; D006801:Humans; D008928:Mitochondria; D009369:Neoplasms; D011505:Protein-Tyrosine Kinases
chemical_list: D000101:Acetyl-CoA C-Acetyltransferase; D011505:Protein-Tyrosine Kinases