title: A metal-free fluorescence turn-on molecular probe for detection of nucleoside triphosphates.
abstract: We report a fluorescence probe 1, which contains a naphthalimide fluorophore with two symmetric peptidic arms equipped with a tailor-made anion-binding motif, the guanidiniocarbonyl pyrrole moiety, for the detection of nucleoside triphosphates. Upon binding to nucleoside triphosphates, especially ATP, 1 shows significant turn-on fluorescence response. Probe 1 can also be applied for the imaging of ATP in cells.
authors.affiliation: Institute for Organic Chemistry, University of Duisburg-Essen, 45117, Essen, Germany. carsten.schmuck@uni-due.de.
authors.forename: Debabrata
authors.initials: D
authors.lastname: Maity
authors.affiliation: Institute for Organic Chemistry, University of Duisburg-Essen, 45117, Essen, Germany. carsten.schmuck@uni-due.de.
authors.forename: Mao
authors.initials: M
authors.lastname: Li
authors.affiliation: Institute for Organic Chemistry, University of Duisburg-Essen, 45117, Essen, Germany. carsten.schmuck@uni-due.de.
authors.forename: Martin
authors.initials: M
authors.lastname: Ehlers
authors.forename: Alba
authors.initials: A
authors.lastname: Gigante
authors.affiliation: Institute for Organic Chemistry, University of Duisburg-Essen, 45117, Essen, Germany. carsten.schmuck@uni-due.de.
authors.forename: Carsten
authors.identifier: 0000-0001-6062-0357
authors.initials: C
authors.lastname: Schmuck
mesh_terms: D000255:Adenosine Triphosphate / Q000032:analysis* / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D008958:Models, Molecular; D008968:Molecular Conformation; D057054:Molecular Imaging; D053644:Naphthalimides / Q000737:chemistry; D010455:Peptides / Q000737:chemistry; D011758:Pyrroles / Q000737:chemistry; D013050:Spectrometry, Fluorescence
chemical_list: D005456:Fluorescent Dyes; D053644:Naphthalimides; D010455:Peptides; D011758:Pyrroles; D000255:Adenosine Triphosphate