title: Genetic Dissection of Variation in Hippocampal Intra- and Infrapyramidal Mossy Fibers in the Mouse.
abstract: This chapter describes the genetic analysis of a morphometric neuroanatomic trait. We used the extended BXD family of recombinant inbred mouse strains with the intent to analyze the genetic bases of heritable differences in hippocampal neurocircuitry and to identify Quantitative Trait Loci that underlie these variations. A detailed description of a GeneNetwork analysis is provided using data for the intra- and infrapyramidal mossy fiber (IIPMF) terminal fields which are strongly correlated with spatial navigation/radial maze learning.
authors.affiliation: Institut de Neurosciences Cognitives et Intégratives d'Aquitaine, UMR 5287, University of Bordeaux, Bat B2 - Allée Geoffroy St. Hilaire, CS 50023, Pessac, France. delprato@bioscienceproject.org.|CNRS, Institut de Neurosciences Cognitives et Intégratives d'Aquitaine, UMR 5287, Pessac, France. delprato@bioscienceproject.org.|BioScience Project, 3266, Wakefield, MA, 01880, USA. delprato@bioscienceproject.org.
authors.forename: Anna
authors.initials: A
authors.lastname: Delprato
authors.affiliation: Institut de Neurosciences Cognitives et Intégratives d'Aquitaine, UMR 5287, University of Bordeaux, Bat B2 - Allée Geoffroy St. Hilaire, CS 50023, Pessac, France.|CNRS, Institut de Neurosciences Cognitives et Intégratives d'Aquitaine, UMR 5287, Pessac, France.|BioScience Project, 3266, Wakefield, MA, 01880, USA.
authors.forename: Wim E
authors.initials: WE
authors.lastname: Crusio
mesh_terms: D000818:Animals; D015415:Biomarkers; D002874:Chromosome Mapping; D019295:Computational Biology / Q000379:methods; D004843:Epistasis, Genetic; D005260:Female; D005786:Gene Expression Regulation; D053263:Gene Regulatory Networks; D056726:Genetic Association Studies; D014644:Genetic Variation; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D019599:Mossy Fibers, Hippocampal / Q000378:metabolism*; D040641:Quantitative Trait Loci; D019655:Quantitative Trait, Heritable; D011995:Recombination, Genetic; D012984:Software
chemical_list: D015415:Biomarkers
keywords: Complex traits; Hippocampal morphometry; Intra- and infrapyramidal mossy fibers; Quantitative trait loci; Recombinant inbred mice; Systems genetics