title: Long-Term Real-Time In Vivo Drug Release Monitoring with AIE Thermogelling Polymer.
abstract: A new drug concentration meter is developed. In vivo drug release can be monitored precisely via a self-indicating drug delivery system consisting of a new aggregation-induced emission thermoresponsive hydrogel. By taking the advantage of a self-indicating system, one can easily detect the depletion of drugs, and reinject to maintain a dosage in the optimal therapeutic window.
authors.affiliation: Institute of Materials Research and Engineering (IMRE), 2 Fusionopolis Way, #08-03 Innovis, Singapore, 138634, Singapore.
authors.forename: Sing Shy
authors.initials: SS
authors.lastname: Liow
authors.affiliation: Institute of Materials Research and Engineering (IMRE), 2 Fusionopolis Way, #08-03 Innovis, Singapore, 138634, Singapore.
authors.forename: Qingqing
authors.initials: Q
authors.lastname: Dou
authors.affiliation: Institute of Materials Research and Engineering (IMRE), 2 Fusionopolis Way, #08-03 Innovis, Singapore, 138634, Singapore.
authors.forename: Dan
authors.initials: D
authors.lastname: Kai
authors.affiliation: Institute of Materials Research and Engineering (IMRE), 2 Fusionopolis Way, #08-03 Innovis, Singapore, 138634, Singapore.
authors.forename: Zibiao
authors.initials: Z
authors.lastname: Li
authors.affiliation: Institute of Materials Research and Engineering (IMRE), 2 Fusionopolis Way, #08-03 Innovis, Singapore, 138634, Singapore.
authors.forename: Sigit
authors.initials: S
authors.lastname: Sugiarto
authors.affiliation: Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, 999077, China.
authors.forename: Chris Yee Yung
authors.initials: CY
authors.lastname: Yu
authors.affiliation: Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, 999077, China.
authors.forename: Ryan Tsz Kin
authors.initials: RT
authors.lastname: Kwok
authors.affiliation: Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian, 361102, P. R. China.
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Chen
authors.affiliation: Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian, 361102, P. R. China.
authors.forename: Yun-Long
authors.initials: YL
authors.lastname: Wu
authors.affiliation: Lee Kong Chian School of Medicine, Nanyang Technological University, Experimental Medicine Building, Singapore, 636921, Singapore.
authors.forename: Seow Theng
authors.initials: ST
authors.lastname: Ong
authors.affiliation: Lee Kong Chian School of Medicine, Nanyang Technological University, Experimental Medicine Building, Singapore, 636921, Singapore.
authors.forename: Atish
authors.initials: A
authors.lastname: Kizhakeyil
authors.affiliation: Lee Kong Chian School of Medicine, Nanyang Technological University, Experimental Medicine Building, Singapore, 636921, Singapore.
authors.forename: Navin K
authors.initials: NK
authors.lastname: Verma
authors.affiliation: Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, 999077, China.
authors.forename: Ben Zhong
authors.initials: BZ
authors.lastname: Tang
authors.affiliation: Institute of Materials Research and Engineering (IMRE), 2 Fusionopolis Way, #08-03 Innovis, Singapore, 138634, Singapore.|Singapore Eye Research Institute, 11 Third Hospital Avenue, The Academia 20 College Road, Singapore, 168751, Singapore.|Department of Materials Science and Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore, 117576, Singapore.
authors.forename: Xian Jun
authors.initials: XJ
authors.lastname: Loh
mesh_terms: D000072283:A549 Cells; D000818:Animals; D003199:Computer Systems; D065546:Drug Liberation; D005782:Gels / Q000737:chemistry*; D056945:Hep G2 Cells; D006801:Humans; D051379:Mice; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D013696:Temperature; D013997:Time Factors
chemical_list: D005782:Gels; D011108:Polymers
keywords: AIE micelles; drug delivery; fluorescence dyes; imaging; thermogels