title: Bone Area Provides a Responsive Outcome Measure for Bone Changes in Short-term Knee Osteoarthritis Studies.
abstract: To analyze the 3-D bone area from an osteoarthritis (OA) cohort demonstrating no change in cartilage thickness.
  
  
  
  Twenty-seven women with painful medial knee OA had magnetic resonance images at 0, 3, and 6 months. Images were analyzed using active appearance models.
  
  
  
  At 3 and 6 months, the mean change in medial femoral bone area was 0.34% (95% CI 0.04-0.64) and 0.61% (95% CI 0.32-0.90), respectively. Forty-one percent of the subjects had progression greater than the smallest detectable difference at 6 months.
  
  
  
  In this small cohort at high risk of OA progression, bone area changed at 3 and 6 months when cartilage morphometric measures did not.
authors.affiliation: From the Imorphics; Biomedical Imaging Institute, Manchester Academic Health Sciences Centre, University of Manchester, Manchester; Respiratory, Inflammation, Autoimmunity Innovative Medicines and Early Development (IMED), AstraZeneca, Cambridge; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; UK National Institute for Health Research (NIHR) Leeds Musculoskeletal Biomedical Research Unit, Leeds, UK; Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia; Rheumatology Department, Royal North Shore Hospital, St. Leonards, Australia. mike@imorphics.com.|M.A. Bowes, PhD, Imorphics; R.A. Maciewicz, PhD, Chief Scientist, Respiratory, Inflammation, Autoimmunity IMED, AstraZeneca; J.C. Waterton, PhD, Professor of Translational Imaging, Biomedical Imaging Institute, Manchester Academic Health Sciences Centre, University of Manchester; D.J. Hunter, PhD, Florance and Cope Chair of Rheumatology, Professor of Medicine, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; P.G. Conaghan, MBBS, PhD, FRACP, FRCP, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit. mike@imorphics.com.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Bowes
authors.affiliation: From the Imorphics; Biomedical Imaging Institute, Manchester Academic Health Sciences Centre, University of Manchester, Manchester; Respiratory, Inflammation, Autoimmunity Innovative Medicines and Early Development (IMED), AstraZeneca, Cambridge; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; UK National Institute for Health Research (NIHR) Leeds Musculoskeletal Biomedical Research Unit, Leeds, UK; Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia; Rheumatology Department, Royal North Shore Hospital, St. Leonards, Australia.|M.A. Bowes, PhD, Imorphics; R.A. Maciewicz, PhD, Chief Scientist, Respiratory, Inflammation, Autoimmunity IMED, AstraZeneca; J.C. Waterton, PhD, Professor of Translational Imaging, Biomedical Imaging Institute, Manchester Academic Health Sciences Centre, University of Manchester; D.J. Hunter, PhD, Florance and Cope Chair of Rheumatology, Professor of Medicine, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; P.G. Conaghan, MBBS, PhD, FRACP, FRCP, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit.
authors.forename: Rose A
authors.initials: RA
authors.lastname: Maciewicz
authors.affiliation: From the Imorphics; Biomedical Imaging Institute, Manchester Academic Health Sciences Centre, University of Manchester, Manchester; Respiratory, Inflammation, Autoimmunity Innovative Medicines and Early Development (IMED), AstraZeneca, Cambridge; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; UK National Institute for Health Research (NIHR) Leeds Musculoskeletal Biomedical Research Unit, Leeds, UK; Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia; Rheumatology Department, Royal North Shore Hospital, St. Leonards, Australia.|M.A. Bowes, PhD, Imorphics; R.A. Maciewicz, PhD, Chief Scientist, Respiratory, Inflammation, Autoimmunity IMED, AstraZeneca; J.C. Waterton, PhD, Professor of Translational Imaging, Biomedical Imaging Institute, Manchester Academic Health Sciences Centre, University of Manchester; D.J. Hunter, PhD, Florance and Cope Chair of Rheumatology, Professor of Medicine, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; P.G. Conaghan, MBBS, PhD, FRACP, FRCP, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit.
authors.forename: John C
authors.initials: JC
authors.lastname: Waterton
authors.affiliation: From the Imorphics; Biomedical Imaging Institute, Manchester Academic Health Sciences Centre, University of Manchester, Manchester; Respiratory, Inflammation, Autoimmunity Innovative Medicines and Early Development (IMED), AstraZeneca, Cambridge; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; UK National Institute for Health Research (NIHR) Leeds Musculoskeletal Biomedical Research Unit, Leeds, UK; Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia; Rheumatology Department, Royal North Shore Hospital, St. Leonards, Australia.|M.A. Bowes, PhD, Imorphics; R.A. Maciewicz, PhD, Chief Scientist, Respiratory, Inflammation, Autoimmunity IMED, AstraZeneca; J.C. Waterton, PhD, Professor of Translational Imaging, Biomedical Imaging Institute, Manchester Academic Health Sciences Centre, University of Manchester; D.J. Hunter, PhD, Florance and Cope Chair of Rheumatology, Professor of Medicine, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; P.G. Conaghan, MBBS, PhD, FRACP, FRCP, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit.
authors.forename: David J
authors.initials: DJ
authors.lastname: Hunter
authors.affiliation: From the Imorphics; Biomedical Imaging Institute, Manchester Academic Health Sciences Centre, University of Manchester, Manchester; Respiratory, Inflammation, Autoimmunity Innovative Medicines and Early Development (IMED), AstraZeneca, Cambridge; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; UK National Institute for Health Research (NIHR) Leeds Musculoskeletal Biomedical Research Unit, Leeds, UK; Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia; Rheumatology Department, Royal North Shore Hospital, St. Leonards, Australia.|M.A. Bowes, PhD, Imorphics; R.A. Maciewicz, PhD, Chief Scientist, Respiratory, Inflammation, Autoimmunity IMED, AstraZeneca; J.C. Waterton, PhD, Professor of Translational Imaging, Biomedical Imaging Institute, Manchester Academic Health Sciences Centre, University of Manchester; D.J. Hunter, PhD, Florance and Cope Chair of Rheumatology, Professor of Medicine, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; P.G. Conaghan, MBBS, PhD, FRACP, FRCP, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit.
authors.forename: Philip G
authors.initials: PG
authors.lastname: Conaghan
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002358:Cartilage, Articular / Q000000981:diagnostic imaging*; D018450:Disease Progression; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging*; D006801:Humans; D007719:Knee Joint / Q000000981:diagnostic imaging*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000000981:diagnostic imaging*; D010329:Patella / Q000000981:diagnostic imaging*; D013977:Tibia / Q000000981:diagnostic imaging
keywords: BONE; KNEE; OSTEOARTHRITIS