title: Acute Liver Failure Caused by Primary Non-Hodgkin's Lymphoma of the Liver.
abstract: BACKGROUND
  Acute liver failure (ALF) is a rare syndrome involving maximum liver dysfunction. This disease is characterized by a less than 26-week history of coagulopathy (INR ≥1.5) and hepatic encephalopathy and generally occurs in patients without any previously known disease.
  
  
  METHODS
  We report the case of a healthy 25-year-old subject who presented with fulminant liver failure caused by a primary non-Hodgkin's lymphoma of the liver that required emergency liver transplantation. Diagnosis was based on pathologic confirmation of T-cell/histiocyte-rich large B-cell lymphoma and submassive hepatocyte necrosis. One year after surgery, the patient remains in complete remission.
  
  
  CONCLUSIONS
  Fulminant liver failure is a sudden-onset severe disease that can be caused by a primary non-Hodgkin's lymphoma of the liver, which accounts for <1% of extranodal lymphomas. The diagnosis of this rare disease demands high diagnostic suspicion, and progression can be prevented through liver transplantation.
authors.affiliation: Liver Transplant Unit, Regional Hospital, Málaga, Spain. Electronic address: laura_romacho@hotmail.com.
authors.forename: L
authors.initials: L
authors.lastname: Romacho López
authors.affiliation: Liver Transplant Unit, Regional Hospital, Málaga, Spain.
authors.forename: F J
authors.initials: FJ
authors.lastname: León Díaz
authors.affiliation: Liver Transplant Unit, Regional Hospital, Málaga, Spain.
authors.forename: B
authors.initials: B
authors.lastname: Sánchez Pérez
authors.affiliation: Liver Transplant Unit, Regional Hospital, Málaga, Spain.
authors.forename: J A
authors.initials: JA
authors.lastname: Pérez Daga
authors.affiliation: Liver Transplant Unit, Regional Hospital, Málaga, Spain.
authors.forename: J L
authors.initials: JL
authors.lastname: Fernández Aguilar
authors.affiliation: Liver Transplant Unit, Regional Hospital, Málaga, Spain.
authors.forename: M C
authors.initials: MC
authors.lastname: Montiel Casado
authors.affiliation: Liver Transplant Unit, Regional Hospital, Málaga, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Aranda Narváez
authors.affiliation: Liver Transplant Unit, Regional Hospital, Málaga, Spain.
authors.forename: M A
authors.initials: MA
authors.lastname: Suárez Muñoz
authors.affiliation: Liver Transplant Unit, Regional Hospital, Málaga, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Santoyo Santoyo
mesh_terms: D000328:Adult; D006801:Humans; D017114:Liver Failure, Acute / Q000209:etiology* / Q000601:surgery*; D016031:Liver Transplantation; D016393:Lymphoma, B-Cell / Q000150:complications* / Q000175:diagnosis / Q000601:surgery*; D008297:Male; D012074:Remission Induction