title: Nutrimetabolomics: An Update on Analytical Approaches to Investigate the Role of Plant-Based Foods and Their Bioactive Compounds in Non-Communicable Chronic Diseases.
abstract: Metabolomics is the study of low-weight molecules present in biological samples such as biofluids, tissue/cellular extracts, and culture media. Metabolomics research is increasing, and at the moment, it has several applications in the food science and nutrition fields. In the present review, we provide an update about the most frequently used methodologies and metabolomic platforms in these areas. Also, we discuss different metabolomic strategies regarding the discovery of new bioactive compounds (BACs) in plant-based foods. Furthermore, we review the existing literature related to the use of metabolomics to investigate the potential protective role of BACs in the prevention and treatment of non-communicable chronic diseases, namely cardiovascular disease, diabetes, and cancer.
authors.affiliation: Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology "José Mataix", Center for Biomedical Research, University of Granada, 18100 Granada, Spain. odrangel@ugr.es.
authors.forename: Oscar Daniel
authors.initials: OD
authors.lastname: Rangel-Huerta
authors.affiliation: Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology "José Mataix", Center for Biomedical Research, University of Granada, 18100 Granada, Spain. agil@ugr.es.|Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, Ciberobn, 28029 Madrid, Spain. agil@ugr.es.
authors.forename: Angel
authors.initials: A
authors.lastname: Gil
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000378:metabolism / Q000517:prevention & control; D002908:Chronic Disease / Q000517:prevention & control; D003920:Diabetes Mellitus / Q000378:metabolism / Q000517:prevention & control; D006801:Humans; D055432:Metabolomics / Q000379:methods*; D009369:Neoplasms / Q000378:metabolism / Q000517:prevention & control; D010945:Plants, Edible
keywords: bioactive compounds; metabolomics; non-communicable chronic diseases; nutrimetabolomics; plant-based food