title: Erythropoietin and thrombopoietin mimetics: Natural alternatives to erythrocyte and platelet disorders.
abstract: Erythropoietin (EPO) and thrombopoietin (TPO) plays a major role in the regulation of hematopoietic development. Though, blood transfusion was the most widely used method to treat low blood count, over the years with advancements in recombinant technology and drug designing, the EPO and TPO mimetics are dominating the therapeutics industry. On the other hand, the recombinant human EPO and TPO are associated either with reduced half-life or immune reactions. The restoration of alternate medicine in recent years has the hope to overcome limitations associated with recombinant technology, to treat various disorder including blood diseases, with low to no side effects. The work in recent years on plant derived mimetics suggests a paradigm shift in the way diseases are treated. Here, we are providing a comprehensive review on the EPO and TPO recombinant counterparts and synthetic mimetics studied till date with a focus on the need for more natural alternatives.
authors.affiliation: Department of Biotechnology, GITAM Institute of Science, GITAM University, Visakhapatnam, 530045 Andhra Pradesh, India. Electronic address: guttiusha@gmail.com.
authors.forename: Usha
authors.initials: U
authors.lastname: Gutti
authors.affiliation: Stem Cells and Haematological Disorders Laboratory, Department of Biochemistry, School of Life Sciences, University of Hyderabad, Gachibowli, Hyderabad, 500046 Telangana, India.
authors.forename: Satya Ratan
authors.initials: SR
authors.lastname: Pasupuleti
authors.affiliation: Stem Cells and Haematological Disorders Laboratory, Department of Biochemistry, School of Life Sciences, University of Hyderabad, Gachibowli, Hyderabad, 500046 Telangana, India.
authors.forename: Itishri
authors.initials: I
authors.lastname: Sahu
authors.affiliation: Stem Cells and Haematological Disorders Laboratory, Department of Biochemistry, School of Life Sciences, University of Hyderabad, Gachibowli, Hyderabad, 500046 Telangana, India.
authors.forename: Aneesh
authors.initials: A
authors.lastname: Kotipalli
authors.affiliation: Stem Cells and Haematological Disorders Laboratory, Department of Biochemistry, School of Life Sciences, University of Hyderabad, Gachibowli, Hyderabad, 500046 Telangana, India.
authors.forename: Ram Babu
authors.initials: RB
authors.lastname: Undi
authors.affiliation: Stem Cells and Haematological Disorders Laboratory, Department of Biochemistry, School of Life Sciences, University of Hyderabad, Gachibowli, Hyderabad, 500046 Telangana, India.
authors.forename: Ravinder
authors.initials: R
authors.lastname: Kandi
authors.affiliation: Department of Biotechnology, GITAM Institute of Science, GITAM University, Visakhapatnam, 530045 Andhra Pradesh, India.
authors.forename: Raja Gopal
authors.initials: RG
authors.lastname: Venakata Saladi
authors.affiliation: Stem Cells and Haematological Disorders Laboratory, Department of Biochemistry, School of Life Sciences, University of Hyderabad, Gachibowli, Hyderabad, 500046 Telangana, India. Electronic address: guttiravi@gmail.com.
authors.forename: Ravi Kumar
authors.initials: RK
authors.lastname: Gutti
mesh_terms: D000818:Animals; D040761:Biomimetic Materials / Q000627:therapeutic use*; D001791:Blood Platelet Disorders / Q000188:drug therapy*; D004912:Erythrocytes / Q000187:drug effects*; D004921:Erythropoietin / Q000627:therapeutic use; D006801:Humans; D011994:Recombinant Proteins / Q000627:therapeutic use; D013926:Thrombopoietin / Q000627:therapeutic use
chemical_list: D011994:Recombinant Proteins; D004921:Erythropoietin; D013926:Thrombopoietin
keywords: Alternate medicine; EPO; Erythropoietin; Haematopoiesis; Mimetics; Plant products; TPO; Thrombopoietin