title: Self-assembled Pt2L2boxes strongly bind G-quadruplex DNA and influence gene expression in cancer cells.
abstract: Supramolecular Pt(ii) quadrangular boxes bind native and G-quadruplex DNA motifs in a size-dependent fashion. Three Pt molecular squares of distinct size show biological activity against cancer cells and heavily influence the expression of genes known to form G-quadruplexes in their promoter regions. The smallest Pt-box displays less activity but more selectivity for a quadruplex formed in the c-Kit gene.
authors.affiliation: Universidade da Coruña, Departamento de Química Fundamental and Centro de Investigacións Científicas Avanzadas, Facultade de Ciencias, E-15071 A Coruña, Spain. carlos.peinador@udc.es.
authors.forename: O
authors.initials: O
authors.lastname: Domarco
authors.affiliation: Medical University Vienna, Department of Medicine I, Institute of Cancer Research and Comprehensive Cancer Center, Borschkegasse 8a, A-1090 Vienna, Austria.
authors.forename: D
authors.initials: D
authors.lastname: Lötsch
authors.affiliation: Medical University Vienna, Department of Medicine I, Institute of Cancer Research and Comprehensive Cancer Center, Borschkegasse 8a, A-1090 Vienna, Austria.
authors.forename: J
authors.initials: J
authors.lastname: Schreiber
authors.affiliation: Medical University Vienna, Department of Medicine I, Institute of Cancer Research and Comprehensive Cancer Center, Borschkegasse 8a, A-1090 Vienna, Austria.
authors.forename: C
authors.initials: C
authors.lastname: Dinhof
authors.affiliation: Medical University Vienna, Department of Medicine I, Institute of Cancer Research and Comprehensive Cancer Center, Borschkegasse 8a, A-1090 Vienna, Austria.
authors.forename: S
authors.initials: S
authors.lastname: Van Schoonhoven
authors.affiliation: Universidade da Coruña, Departamento de Química Fundamental and Centro de Investigacións Científicas Avanzadas, Facultade de Ciencias, E-15071 A Coruña, Spain. carlos.peinador@udc.es.
authors.forename: M D
authors.initials: MD
authors.lastname: García
authors.affiliation: Universidade da Coruña, Departamento de Química Fundamental and Centro de Investigacións Científicas Avanzadas, Facultade de Ciencias, E-15071 A Coruña, Spain. carlos.peinador@udc.es.
authors.forename: C
authors.initials: C
authors.lastname: Peinador
authors.affiliation: University of Vienna, Institute of Inorganic Chemistry, Waehringerstrasse 42, A-1090 Vienna, Austria and Research Platform "Translational Cancer Therapy Research", University of Vienna and Medical University of Vienna, Vienna, Austria. alessio.terenzi@univie.ac.at.
authors.forename: B K
authors.initials: BK
authors.lastname: Keppler
authors.affiliation: Medical University Vienna, Department of Medicine I, Institute of Cancer Research and Comprehensive Cancer Center, Borschkegasse 8a, A-1090 Vienna, Austria and Research Platform "Translational Cancer Therapy Research", University of Vienna and Medical University of Vienna, Vienna, Austria. alessio.terenzi@univie.ac.at.
authors.forename: W
authors.initials: W
authors.lastname: Berger
authors.affiliation: University of Vienna, Institute of Inorganic Chemistry, Waehringerstrasse 42, A-1090 Vienna, Austria and Research Platform "Translational Cancer Therapy Research", University of Vienna and Medical University of Vienna, Vienna, Austria. alessio.terenzi@univie.ac.at.
authors.forename: A
authors.identifier: http://orcid.org/0000-0001-9751-1373
authors.initials: A
authors.lastname: Terenzi