title: The ancient cytokine IL-17D is regulated by Nrf2 and mediates tumor and virus surveillance.
abstract: Early stage immune responses can dictate the severity and outcome of inflammatory processes such as tumor growth and viral infection. Cytokines such as the interleukin 17 (IL-17) family and cellular stress defense (e.g., anti-oxidant) pathways have evolved early and regulate disease surveillance in vertebrates and invertebrates as far back as Caenorhabditis elegans. Our group has recently found a new role for nuclear factor erythroid-derived 2-like 2 (Nrf2) in regulating early anti-cancer immune responses by inducing IL-17D and recruiting natural killer (NK) cells. In this Cytokine Stimulus, we discuss recent findings that encourage boosting the Nrf2/IL-17D/NK cell axis for the treatment of cancer and viral infection.
authors.affiliation: Department of Pathology, University of California, San Diego, CA 92093, USA.
authors.forename: Ruth
authors.initials: R
authors.lastname: Seelige
authors.affiliation: Department of Pathology, University of California, San Diego, CA 92093, USA.
authors.forename: Allen
authors.initials: A
authors.lastname: Washington
authors.affiliation: Department of Pathology, University of California, San Diego, CA 92093, USA. Electronic address: jbui@ucsd.edu.
authors.forename: Jack D
authors.initials: JD
authors.lastname: Bui
mesh_terms: D000818:Animals; D007157:Immunologic Surveillance; D020381:Interleukin-17 / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology* / Q000473:pathology; D051379:Mice; D051267:NF-E2-Related Factor 2 / Q000276:immunology*; D009374:Neoplasms, Experimental / Q000276:immunology* / Q000473:pathology; D014777:Virus Diseases / Q000276:immunology* / Q000473:pathology
chemical_list: C515931:Il17d protein, mouse; D020381:Interleukin-17; D051267:NF-E2-Related Factor 2; C495636:Nfe2l2 protein, mouse
keywords: Cancer and virus surveillance; Early-evolved pathogen response; IL-17D; Nrf2