title: Chemical Methods for Probing Virus-Host Proteomic Interactions.
abstract: Interactions between host and pathogen proteins constitute an important aspect of both infectivity and the host immune response. Different viruses have evolved complex mechanisms to hijack host-cell machinery and metabolic pathways to redirect resources and energy flow toward viral propagation. These interactions are often critical to the virus, and thus understanding these interactions at a molecular level gives rise to opportunities to develop novel antiviral strategies for therapeutic intervention. This review summarizes current advances in chemoproteomic methods for studying these molecular altercations between different viruses and their hosts.
authors.affiliation: Department of Chemistry and Biomolecular Sciences, Centre for Chemical and Synthetic Biology, University of Ottawa , 10 Marie-Curie Private, Ottawa, Ontario, Canada K1N 6N5.
authors.forename: Miroslava
authors.initials: M
authors.lastname: Strmiskova
authors.affiliation: Department of Chemistry and Biomolecular Sciences, Centre for Chemical and Synthetic Biology, University of Ottawa , 10 Marie-Curie Private, Ottawa, Ontario, Canada K1N 6N5.
authors.forename: Geneviève F
authors.initials: GF
authors.lastname: Desrochers
authors.affiliation: Department of Chemistry and Biomolecular Sciences, Centre for Chemical and Synthetic Biology, University of Ottawa , 10 Marie-Curie Private, Ottawa, Ontario, Canada K1N 6N5.
authors.forename: Tyler A
authors.initials: TA
authors.lastname: Shaw
authors.affiliation: Department of Chemistry and Biomolecular Sciences, Centre for Chemical and Synthetic Biology, University of Ottawa , 10 Marie-Curie Private, Ottawa, Ontario, Canada K1N 6N5.
authors.forename: Megan H
authors.initials: MH
authors.lastname: Powdrill
authors.affiliation: Department of Chemistry and Biomolecular Sciences, Centre for Chemical and Synthetic Biology, University of Ottawa , 10 Marie-Curie Private, Ottawa, Ontario, Canada K1N 6N5.
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Lafreniere
authors.affiliation: Department of Chemistry and Biomolecular Sciences, Centre for Chemical and Synthetic Biology, University of Ottawa , 10 Marie-Curie Private, Ottawa, Ontario, Canada K1N 6N5.
authors.forename: John Paul
authors.initials: JP
authors.lastname: Pezacki
mesh_terms: D054884:Host-Pathogen Interactions; D006801:Humans; D040901:Proteomics / Q000379:methods* / Q000639:trends; D014777:Virus Diseases / Q000188:drug therapy / Q000503:physiopathology* / Q000821:virology*; D018406:Virus Physiological Phenomena; D014780:Viruses / Q000737:chemistry / Q000235:genetics
keywords: activity-based protein profiling; chemoproteomics; protein interactions; quantitative proteomics