title: The first total synthesis of the marine acetylenic alcohol, lembehyne B - a selective inducer of early apoptosis in leukemia cancer cells.
abstract: The communication reports a new stereoselective method for the synthesis of a natural acetylenic alcohol, lembehyne B. The key stage of the process uses new cross-cyclomagnesiation reaction of aliphatic and oxygenated 1,2-dienes with Grignard reagents in the presence of a catalytic amount of Cp2TiCl2. A study of the cytotoxic properties of lembehyne B on tumor cell lines using flow cytometry demonstrated that this is a selective inducer of early apoptosis of the Jurkat, HL-60 and K562 cell cultures and hypodiploid (sub-G1) sub-population inducer in cell cycle studies for all cell lines used.
authors.affiliation: Institute of Petrochemistry and Catalysis, Russian Academy of Sciences, 141 Prospekt Oktyabrya, 450075, Ufa, Russian Federation. DyakonovVA@gmail.com and Department of Immunology and Human Reproductive Health Bashkir State Medical University, Lenin Street, 3, 450003, Ufa, Russian Federation. Dzhemilev@mail.ru.
authors.forename: Lilya U
authors.initials: LU
authors.lastname: Dzhemileva
authors.affiliation: Institute of Petrochemistry and Catalysis, Russian Academy of Sciences, 141 Prospekt Oktyabrya, 450075, Ufa, Russian Federation. DyakonovVA@gmail.com.
authors.forename: Vladimir A
authors.initials: VA
authors.lastname: D'yakonov
authors.affiliation: Institute of Petrochemistry and Catalysis, Russian Academy of Sciences, 141 Prospekt Oktyabrya, 450075, Ufa, Russian Federation. DyakonovVA@gmail.com.
authors.forename: Aleksey A
authors.initials: AA
authors.lastname: Makarov
authors.affiliation: Institute of Petrochemistry and Catalysis, Russian Academy of Sciences, 141 Prospekt Oktyabrya, 450075, Ufa, Russian Federation. DyakonovVA@gmail.com.
authors.forename: Evgeny N
authors.initials: EN
authors.lastname: Andreev
authors.affiliation: Institute of Petrochemistry and Catalysis, Russian Academy of Sciences, 141 Prospekt Oktyabrya, 450075, Ufa, Russian Federation. DyakonovVA@gmail.com.
authors.forename: Milyausha M
authors.initials: MM
authors.lastname: Yunusbaeva
authors.affiliation: Institute of Petrochemistry and Catalysis, Russian Academy of Sciences, 141 Prospekt Oktyabrya, 450075, Ufa, Russian Federation. DyakonovVA@gmail.com.
authors.forename: Usein M
authors.initials: UM
authors.lastname: Dzhemilev
mesh_terms: D000438:Alcohols / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000480:Alkynes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D002453:Cell Cycle / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D005233:Fatty Alcohols / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000438:Alcohols; D000480:Alkynes; D000970:Antineoplastic Agents; D005233:Fatty Alcohols; C572476:acetylenic alcohol; C000626577:lembehyne B