title: Biomarker MicroRNAs for Diagnosis, Prognosis and Treatment of Hepatocellular Carcinoma: A Functional Survey and Comparison.
abstract: Hepatocellular Carcinoma (HCC) is one of the most common malignant tumors with high incidence and mortality rate. Precision and effective biomarkers are therefore urgently needed for the early diagnosis and prognostic estimation. MicroRNAs (miRNAs) are important regulators which play functions in various cellular processes and biological activities. Accumulating evidence indicated that the abnormal expression of miRNAs are closely associated with HCC initiation and progression. Recently, many biomarker miRNAs for HCC have been identified from blood or tissues samples, however, the universality and specificity on clinicopathological features of them are less investigated. In this review, we comprehensively surveyed and compared the diagnostic, prognostic, and therapeutic roles of HCC biomarker miRNAs in blood and tissues based on the cancer hallmarks, etiological factors as well as ethnic groups, which will be helpful to the understanding of the pathogenesis of biomarker miRNAs in HCC development and further provide accurate clinical decisions for HCC diagnosis and treatment.
authors.affiliation: Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.|Center for Systems Biology, Soochow University, Suzhou, 215006, China.
authors.forename: Sijia
authors.initials: S
authors.lastname: Shen
authors.affiliation: Center for Systems Biology, Soochow University, Suzhou, 215006, China.
authors.forename: Yuxin
authors.initials: Y
authors.lastname: Lin
authors.affiliation: Center for Systems Biology, Soochow University, Suzhou, 215006, China.
authors.forename: Xuye
authors.initials: X
authors.lastname: Yuan
authors.affiliation: Center for Systems Biology, Soochow University, Suzhou, 215006, China.|Institute of Biological Sciences and Biotechnology, Donghua University, Shanghai, 201620, China.
authors.forename: Li
authors.initials: L
authors.lastname: Shen
authors.affiliation: Center for Systems Biology, Soochow University, Suzhou, 215006, China.
authors.forename: Jiajia
authors.initials: J
authors.lastname: Chen
authors.affiliation: Key Laboratory of Systems Biology, Chinese Academy of Sciences, Shanghai, 200031, China.
authors.forename: Luonan
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Qin
authors.affiliation: Center for Systems Biology, Soochow University, Suzhou, 215006, China.
authors.forename: Bairong
authors.initials: B
authors.lastname: Shen
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood / Q000235:genetics*; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis* / Q000235:genetics / Q000401:mortality / Q000628:therapy; D055088:Early Detection of Cancer; D015972:Gene Expression Regulation, Neoplastic; D053263:Gene Regulatory Networks; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000401:mortality / Q000628:therapy; D035683:MicroRNAs / Q000097:blood / Q000235:genetics*; D009361:Neoplasm Invasiveness; D011379:Prognosis; D015398:Signal Transduction; D016019:Survival Analysis
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs