title: Morphofunctional Renal Alterations in Progeny of Mice Fed Rhodiola kirilowii Extracts or Epigallocatechin During Pregnancy and Lactation.
abstract: Treating infections in pregnant patients is potentially dangerous even when herbal medicines are used. Many herbal medicines, among them extracts from plants of Rhodiola genus, have antimicrobial, anti-inflammatory, and immunostimulatory properties owing to their polyphenol content; they may, however, affect fetal development due to their antiangiogenic properties. The aim of this study was to explain whether daily feeding pregnant and lactating mice with 20 mg/kg Rhodiola kirilowii aqueous (RKW) or 50% hydro-alcoholic (RKW-A) extracts, or 0.2 mg/kg epigallocatechin (EGC, antiangiogenic compound of Rhodiola extracts), may lead to abnormalities in morphology and function of the kidneys of adult progeny. Such abnormalities were not observed in the kidneys of 6-week-old offspring, neither in RKW nor in the control group. However, the progeny of RKW-A- or EGC-fed mothers presented morphometric abnormalities in the kidney structure, with a significantly higher number of glomeruli/mm2and a lower diameter of glomeruli (RKW-A group) or a significantly higher glomeruli diameter (EGC), than in the control and RKW groups. Abnormalities in serum vascular endothelial growth factor, tumor necrosis factor (TNF)-alpha, urea, creatinine, and cystatin C levels were also found. We recommend caution in long-term use of RKW-A extract and EGC-rich foods during pregnancy and lactation.
authors.affiliation: 1 Department of Regenerative Medicine, Military Institute of Hygiene and Epidemiology , Warsaw, Poland .
authors.forename: Sławomir
authors.initials: S
authors.lastname: Lewicki
authors.affiliation: 2 Department of Microwave Safety, Military Institute of Hygiene and Epidemiology , Warsaw, Poland .|3 Pathomorphology Department, Center for Biostructure Research; Warsaw Medical University , Warsaw, Poland .
authors.forename: Ewa
authors.initials: E
authors.lastname: Skopińska-Różewska
authors.affiliation: 4 Department of Immunology, Biochemistry and Nutrition; Warsaw Medical University , Warsaw, Poland .
authors.forename: Barbara Joanna
authors.initials: BJ
authors.lastname: Bałan
authors.affiliation: 5 Department of Pediatrics, Nephrology and Allergology, Military Institute of Medicine , Warsaw, Poland .
authors.forename: Bolesław
authors.initials: B
authors.lastname: Kalicki
authors.affiliation: 6 Department of Pathology, Military Institute of Medicine , Warsaw, Poland .
authors.forename: Janusz
authors.initials: J
authors.lastname: Patera
authors.affiliation: 7 Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences , Poland, Warsaw, Poland .
authors.forename: Jacek
authors.initials: J
authors.lastname: Wilczak
authors.affiliation: 8 Pathomorphology Department, National Institute of Geriatrics , Rheumatology and Rehabilitation, Warsaw, Poland .
authors.forename: Aleksander
authors.initials: A
authors.lastname: Wasiutyński
authors.affiliation: 1 Department of Regenerative Medicine, Military Institute of Hygiene and Epidemiology , Warsaw, Poland .
authors.forename: Robert
authors.initials: R
authors.lastname: Zdanowski
mesh_terms: D000818:Animals; D003404:Creatinine / Q000097:blood; D055316:Cystatin C / Q000097:blood; D005260:Female; D006801:Humans; D007668:Kidney / Q000033:anatomy & histology / Q000254:growth & development* / Q000378:metabolism; D007774:Lactation; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010936:Plant Extracts / Q000009:adverse effects / Q000378:metabolism*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000378:metabolism* / Q000503:physiopathology; D029771:Rhodiola / Q000009:adverse effects* / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D042461:Vascular Endothelial Growth Factor A / Q000097:blood
chemical_list: D055316:Cystatin C; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha; D042461:Vascular Endothelial Growth Factor A; D003404:Creatinine
keywords: medicinal food; medicinal plants; mice; renal impairments