title: Gentamicin-mediated ototoxicity and nephrotoxicity: A clinical trial study.
abstract: BACKGROUND
  Aminoglycosides and mainly gentamicin are the most important antimicrobial agents. Two different methods of administration exist: Single and multiple doses. There has always been a controversy about the less harmful administration method, to minimize adverse effects of gentamicin - deafness and renal insufficiency. In this study, it was aimed to compare two different methods of administration to figure out the least harmful treatment method.
  
  
  METHODS
  In a clinical study, eighty patients aged 12-55 years who were admitted with sepsis syndrome were included in the study; they were divided into two groups: The first group received single-dose treatment (5 mg/kg) whereas the second group was treated with multiple doses (1.7 mg/kg three times a day) of gentamicin.
  
  
  RESULTS
  The results show that blood urea nitrogen (BUN) and creatinine (CR) levels were decreased in the first group. Both blood urea nitrogen and creatinine and also mean glomerular filtration rate was increased in the same group. In the second group, mean BUN and CR levels were increased while the GFR was decreased in the same group. There was also a gradual increase in GFR in the first group. GFR <80 was decreased from 20% to 5.1% in the first group while increased from 5% to 27.5% in the second group. Results of audiometric studies show 6.1% hearing problem in the first group and 12.8% in the second one.
  
  
  CONCLUSIONS
  Results of the present study showed that nephrotoxicity and ototoxicity are minimized in single-dose administration compared to multiples doses.
authors.affiliation: Chronic Kidney Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Parviz
authors.initials: P
authors.lastname: Saleh
authors.affiliation: Women's Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Shamsi
authors.initials: S
authors.lastname: Abbasalizadeh
authors.affiliation: Department of Ear, Nose and Throat (ENT), Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Saman
authors.initials: S
authors.lastname: Rezaeian
authors.affiliation: Medical Philosophy and History Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Naghavi-Behzad
authors.affiliation: Students' Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Piri
authors.affiliation: Department of Orthopedic Surgery, Shohada Educational Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Hojjat Hossein
authors.initials: HH
authors.lastname: Pourfeizi
keywords: Aminoglycosides; deafness; gentamicin; renal insufficiency