title: Autoimmune-Related Retinopathy and Optic Neuropathy Accompanied by Anti-GAD Antibodies.
abstract: Autoimmune-related retinopathy and optic neuropathy is characterized by visual loss in the presence of antibodies against retina or optic nerve antigens in the absence of neoplasia. We report a case with progressive central visual loss accompanied by latent autoimmune diabetes in an adult. Visual fields, multimodal imaging and electrophysiological testing showed characteristic changes without evidence of neoplasia on positron emission tomography. Immunologic testing revealed abnormal reactivity against a 20 kDa optic nerve antigen and 40 kDa and 62 kDa retina antigens along with antibodies against anti-glutamic acid decarboxylase, a constellation which we believe to be unique.
authors.affiliation: Department of Ophthalmology, Houston Methodist Hospital , Houston, Texas, USA.
authors.forename: Sumayya J
authors.initials: SJ
authors.lastname: Almarzouqi
authors.affiliation: Department of Ophthalmology, Houston Methodist Hospital , Houston, Texas, USA.
authors.forename: Michael L
authors.initials: ML
authors.lastname: Morgan
authors.affiliation: Baylor College of Medicine , Houston, Texas, USA.
authors.forename: Petros E
authors.initials: PE
authors.lastname: Carvounis
authors.affiliation: Department of Ophthalmology, Houston Methodist Hospital, Houston, Texas, USA, ; Baylor College of Medicine, Houston, Texas, USA, ; Departments of Ophthalmology, Neurology, and Neurosurgery, Weill Cornell Medical College, Houston, Texas, USA, ; Department of Ophthalmology, University of Texas Medical Branch, Galveston, Texas, USA, ; Department of Head and Neck Surgery, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA, and ; Department of Ophthalmology, The University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Lee
keywords: ARRON; Anti-GAD; autoimmune optic neuropathy; autoimmune retinopathy; optic nerve autoantibody; retinal autoantibody