title: Gangliocytoma Presenting With Tacrolimus Neurotoxicity in a Renal Transplant Recipient: Case Report.
abstract: Tacrolimus is a widely used macrolide immunosuppressant in transplant surgery, with mild and major neurologic side effects. A 21-year-old woman had undergone preemptive transplantation of a kidney from her mother. On the 1st postoperative day, the patient had headache, nausea, vomiting, and agitation. Magnetic resonance imaging (MRI) of the brain showed hyperintensity and a lesion in the right mesial temporal lobe. After we switched from tacrolimus to cyclosporine, the symptoms regressed. Persistence of the lesion, confirmed by repeated MRI, required that the patient be operated on. Pathologic examination showed the gangliocytoma, a rare brain tumor. Our case shows that preexisting brain lesions may cause tacrolimus-induced neurotoxicity in the early postoperative period.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Alagoz
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Gulcicek
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Oruc
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Trabulus
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey. Electronic address: nseyahi@yahoo.com.
authors.forename: N
authors.initials: N
authors.lastname: Seyahi
mesh_terms: D001932:Brain Neoplasms / Q000150:complications*; D016572:Cyclosporine / Q000627:therapeutic use; D005260:Female; D005729:Ganglioneuroma / Q000150:complications*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation; D008279:Magnetic Resonance Imaging; D020258:Neurotoxicity Syndromes / Q000209:etiology*; D016559:Tacrolimus / Q000009:adverse effects*; D066027:Transplant Recipients; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine; D016559:Tacrolimus