title: Effects of parecoxib on postoperative pain and opioid-related symptoms following gynecologic surgery.
abstract: OBJECTIVE
  To examine the analgesic and opioid-sparing effects of parecoxib following major gynecologic surgery.
  
  
  METHODS
  This is a large subset analysis of patients from a multicenter, randomized, double-blind, placebo-controlled study of parecoxib/valdecoxib (PAR/VAL) for postoperative pain. Pain severity, pain interference with function, opioid use, occurrence of opioid-related symptoms, and Patient/Physician Global Evaluation of Study Medication were compared between placebo and PAR/VAL treatment groups in the days following surgery.
  
  
  RESULTS
  Pain scores were reduced in the PAR/VAL group (n=98), relative to placebo (n=97), on Day 2 (-21%,P<0.001) and Day 3 (-23%,P=0.004). Pain interference with function scores were also significantly lower in the PAR/VAL group, compared with placebo, on Day 2 (-29%,P<0.001) and Day 3 (-28%,P=0.013). Consumption of supplemental morphine was significantly lower in the PAR/VAL group relative to placebo at 24 hours (-37%,P=0.010) and trended lower at 48 (-28%) and 72 hours (-26%). Patients in the PAR/VAL group also had a reduced risk of experiencing specific opioid-related symptoms, including "inability to concentrate" (relative risk =0.53) and "nausea" (relative risk =0.60) on Day 2. Both Patient and Physician Global Evaluation of Study Medication scores were better in the PAR/VAL group than in the placebo group.
  
  
  CONCLUSIONS
  The current study adds support for the use of parecoxib in patients following major gynecologic surgery.
authors.affiliation: Pfizer Inc, New York, NY, USA.
authors.forename: Bruce
authors.initials: B
authors.lastname: Parsons
authors.affiliation: 81st Hospital of Chinese People's Liberation Army, Nanjing, People's Republic of China.
authors.forename: Qijiang
authors.initials: Q
authors.lastname: Zhu
authors.affiliation: Pfizer Investment Co., Ltd, Beijing, People's Republic of China.
authors.forename: Li
authors.initials: L
authors.lastname: Xie
authors.affiliation: Pfizer Inc, New York, NY, USA.
authors.forename: Chunming
authors.initials: C
authors.lastname: Li
authors.affiliation: Pfizer Inc, New York, NY, USA.
authors.forename: Raymond
authors.initials: R
authors.lastname: Cheung
keywords: gynecologic surgery; parecoxib; postoperative pain