title: Cord Blood DNA Methylation Biomarkers for Predicting Neurodevelopmental Outcomes.
abstract: Adverse environmental exposures in pregnancy can significantly alter the development of the fetus resulting in impaired child neurodevelopment. Such exposures can lead to epigenetic alterations like DNA methylation, which may be a marker of poor cognitive, motor and behavioral outcomes in the infant. Here we review studies that have assessed DNA methylation in cord blood following maternal exposures that may impact neurodevelopment of the child. We also highlight some key studies to illustrate the potential for DNA methylation to successfully identify infants at risk for poor outcomes. While the current evidence is limited, in that observations to date are largely correlational, in time and with larger cohorts analyzed and longer term follow-up completed, we may be able to develop epigenetic biomarkers that not only indicate adverse early life exposures but can also be used to identify individuals likely to be at an increased risk of impaired neurodevelopment even in the absence of detailed information regarding prenatal environment.
authors.affiliation: Department of Neonatal Medicine, Women's and Children's Hospital, Adelaide 5006, Australia. nicolette.hodyl@adelaide.edu.au.|School of Medicine, University of Adelaide, Adelaide 5005, Australia. nicolette.hodyl@adelaide.edu.au.|Robinson Research Institute, University of Adelaide, Adelaide 5005, Australia. nicolette.hodyl@adelaide.edu.au.
authors.forename: Nicolette A
authors.initials: NA
authors.lastname: Hodyl
authors.affiliation: School of Medicine, University of Adelaide, Adelaide 5005, Australia. claire.roberts@adelaide.edu.au.|Robinson Research Institute, University of Adelaide, Adelaide 5005, Australia. claire.roberts@adelaide.edu.au.
authors.forename: Claire T
authors.initials: CT
authors.lastname: Roberts
authors.affiliation: Robinson Research Institute, University of Adelaide, Adelaide 5005, Australia. tina.bianco@adelaide.edu.au.|School of Agriculture, Food and Wine, Waite Research Institute, University of Adelaide, Adelaide 5005, Australia. tina.bianco@adelaide.edu.au.
authors.forename: Tina
authors.initials: T
authors.lastname: Bianco-Miotto
keywords: DNA methylation; cord blood; epigenetics; neurodevelopment