title: Traditional Mediterranean plants: characterization and use of an essential oils mixture to treat Malassezia otitis externa in atopic dogs.
abstract: Several plants extracts from Mediterranean countries are traditionally employed in skin troubles both in humans and in animals. Malassezia pachydermatis is a lipophylic yeast responsible for otitis externa and dermatitis in dogs and for cutaneous and systemic disease in humans. Five mixtures of essential oils obtained from Mediterranean plants (Citrus paradisi, Salvia sclarea, Ocimum basilicum, Rosmarinus officinalis, Citrus limon, Anthemis nobilis, Lavandula hybrida and Thymus vulgaris) provided with antifungal and/or anti-inflammatory action assayed in vitro, were tested in vivo versus M. pachydermatis to treat once daily for 2 weeks 25 atopic dogs with Malassezia otitis externa. Mixture composed by C. limon 1%, S. sclarea 0,5%, R. officinalis 1%, A. nobilis 0,5% yielded excellent results in all treated dogs. Despite of clinical resolution after all treatments the number of blastospores did not decrease. This study confirms recent findings suggesting a multifactorial alternative approach for the management of canine Malassezia otitis.
authors.affiliation: a Dipartimento di Scienze Veterinarie , Università degli Studi di Pisa , Pisa , Italy.
authors.forename: Simona
authors.initials: S
authors.lastname: Nardoni
authors.affiliation: b Dipartimento di Farmacia , Università degli Studi di Pisa , Pisa , Italy.
authors.forename: Luisa
authors.initials: L
authors.lastname: Pistelli
authors.affiliation: a Dipartimento di Scienze Veterinarie , Università degli Studi di Pisa , Pisa , Italy.
authors.forename: Ilenia
authors.initials: I
authors.lastname: Baronti
authors.affiliation: b Dipartimento di Farmacia , Università degli Studi di Pisa , Pisa , Italy.
authors.forename: Basma
authors.initials: B
authors.lastname: Najar
authors.affiliation: c Scuola Cimi Koinè , Roma , Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Pisseri
authors.affiliation: b Dipartimento di Farmacia , Università degli Studi di Pisa , Pisa , Italy.
authors.forename: Rose Vanessa
authors.initials: RV
authors.lastname: Bandeira Reidel
authors.affiliation: a Dipartimento di Scienze Veterinarie , Università degli Studi di Pisa , Pisa , Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Papini
authors.affiliation: a Dipartimento di Scienze Veterinarie , Università degli Studi di Pisa , Pisa , Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Perrucci
authors.affiliation: a Dipartimento di Scienze Veterinarie , Università degli Studi di Pisa , Pisa , Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Mancianti
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D003881:Dermatomycoses / Q000188:drug therapy*; D004283:Dog Diseases / Q000188:drug therapy / Q000382:microbiology; D004285:Dogs; D008290:Malassezia / Q000187:drug effects / Q000472:pathogenicity; D008519:Medicine, Traditional; D008826:Microbial Sensitivity Tests; D009822:Oils, Volatile / Q000627:therapeutic use*; D010032:Otitis Externa / Q000188:drug therapy* / Q000382:microbiology / Q000662:veterinary; D010946:Plants, Medicinal / Q000737:chemistry; D027542:Rosmarinus / Q000737:chemistry; D046930:Thymus Plant / Q000737:chemistry
chemical_list: D000935:Antifungal Agents; D009822:Oils, Volatile
keywords: Essential oils; Malassezia; dog; mixtures; otitis externa; treatment