title: Monoterpene Indole Alkaloid-Like Compounds Based on Diversity-Enhanced Extracts of Iridoid-Containing Plants and Their Immune Checkpoint Inhibitory Activity.
abstract: A library of iridoid-conjugated indole alkaloid-like compounds was constructed from diversity-enhanced extracts, which constitutes an approach for increasing the chemical diversity of natural-product-like compounds by combining natural product chemistry and diversity-oriented synthesis. Pharmacological screening of the library revealed a seed compound that can be used for the development of small molecular immune checkpoint inhibitors.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Tohoku University , 6-3, Aza-Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan.
authors.forename: Haruhisa
authors.initials: H
authors.lastname: Kikuchi
authors.affiliation: Graduate School of Pharmaceutical Sciences, Tohoku University , 6-3, Aza-Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Ichinohe
authors.affiliation: Research and Development Center, FUSO Pharmaceutical Industries, LTD. , 2-3-30 Morinomiya, Joto-ku, Osaka 536-8523, Japan.
authors.forename: Shinya
authors.initials: S
authors.lastname: Kida
authors.affiliation: Research and Development Center, FUSO Pharmaceutical Industries, LTD. , 2-3-30 Morinomiya, Joto-ku, Osaka 536-8523, Japan.
authors.forename: Shinya
authors.initials: S
authors.lastname: Murase
authors.affiliation: Research and Development Center, FUSO Pharmaceutical Industries, LTD. , 2-3-30 Morinomiya, Joto-ku, Osaka 536-8523, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Yamada
authors.affiliation: Graduate School of Pharmaceutical Sciences, Tohoku University , 6-3, Aza-Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan.
authors.forename: Yoshiteru
authors.initials: Y
authors.lastname: Oshima