title: New Insight in Cold Pain: Role of Ion Channels, Modulation, and Clinical Perspectives.
abstract: Cold temperature detection involves the process of sensory transduction in cutaneous primary sensory nerve terminals, which converts thermal stimuli into depolarizations of the membrane. This transformation into electrical signals is followed by the subsequent propagation of action potentials in cold-sensitive afferent nerve fibers. A large array of ion channels shapes this process; however, the precise contribution of specific ion channel subtypes to cold perception and cold pain remains elusive. This review aims at giving an update on our current understanding of the role played by TRPs, leak K+and voltage-gated Na+and K+channels in the transduction of cold by nociceptors and in cold-induced pain.
authors.affiliation: Clermont Université, Université d'Auvergne, Pharmacologie fondamentale et clinique de la douleur, 63000 Clermont-Ferrand, France.|Inserm, U 1107, Neuro-Dol, 63000 Clermont-Ferrand, France.
authors.forename: Stéphane
authors.identifier: 0000-0001-5407-4986
authors.initials: S
authors.lastname: Lolignier
authors.affiliation: Laboratoire de Physiologie cellulaire, Inserm U1003, Laboratory of Excellence, Ion Channels Science and Therapeutics, Université Lille 1, 59655 Villeneuve d'Ascq Cedex, France.
authors.forename: Dimitra
authors.initials: D
authors.lastname: Gkika
authors.affiliation: King's College London, Wolfson Centre for Age-Related Diseases Wolfson Wing, SE1 1UL London, United Kingdom.
authors.forename: David
authors.identifier: 0000-0001-7451-8548
authors.initials: D
authors.lastname: Andersson
authors.affiliation: Institut für Biochemie und Biophysik, D-07745 Jena, Germany.
authors.forename: Enrico
authors.initials: E
authors.lastname: Leipold
authors.affiliation: Institute for Molecular Bioscience and School of Pharmacy, University of Queensland, Brisbane, Queensland 4072, Australia.
authors.forename: Irina
authors.identifier: 0000-0002-3594-9588
authors.initials: I
authors.lastname: Vetter
authors.affiliation: Instituto de Neurociencias de Alicante Universidad Miguel Hernandez/CSIC Avda. S. Ramón y Cajal s.n. San Juan de Alicante, 03550 Alicante, Spain.
authors.forename: Felix
authors.initials: F
authors.lastname: Viana
authors.affiliation: Université Côte d'Azur, CNRS UMR 7275, Institut de Pharmacologie Moléculaire et Cellulaire, France, and jerome.busserolles@udamail.fr jnoel@unice.fr.|LabEx Ion Channel Science and Therapeutics, 06560 Valbonne, France.
authors.forename: Jacques
authors.identifier: 0000-0003-4017-2352
authors.initials: J
authors.lastname: Noël
authors.affiliation: Clermont Université, Université d'Auvergne, Pharmacologie fondamentale et clinique de la douleur, 63000 Clermont-Ferrand, France, jerome.busserolles@udamail.fr jnoel@unice.fr.|Inserm, U 1107, Neuro-Dol, 63000 Clermont-Ferrand, France.
authors.forename: Jérôme
authors.identifier: 0000-0001-7542-9520
authors.initials: J
authors.lastname: Busserolles
mesh_terms: D000818:Animals; D003080:Cold Temperature; D019317:Evidence-Based Medicine; D006801:Humans; D015640:Ion Channel Gating / Q000502:physiology; D007473:Ion Channels / Q000378:metabolism*; D009473:Neuronal Plasticity / Q000502:physiology; D009619:Nociceptors / Q000502:physiology*; D010146:Pain / Q000503:physiopathology*; D058748:Pain Perception / Q000502:physiology*; D013697:Thermosensing / Q000502:physiology*
chemical_list: D007473:Ion Channels
keywords: cold pain; ion channels; nociception