title: Metabolic syndrome and atypical antipsychotics: Possibility of prediction and control.
abstract: BACKGROUND
  Schizophrenia and other psychotic disorders are associated with high morbidity and mortality, due to inherent health factors, genetic factors, and factors related to psychopharmacological treatment. Antipsychotics, like other drugs, have side-effects that can substantially affect the physical health of patients, with substantive differences in the side-effect profile and in the patients in which these side-effects occur. To understand and identify these risk groups could help to prevent the occurrence of the undesired effects.
  
  
  METHODS
  A prospective study, with 24 months follow-up, was conducted in order to analyse the physical health of severe mental patients under maintenance treatment with atypical antipsychotics, as well as to determine any predictive parameters at anthropometric and/or analytical level for good/bad outcome of metabolic syndrome in these patients.
  
  
  RESULTS
  There were no significant changes in the physical and biochemical parameters individually analysed throughout the different visits. The baseline abdominal circumference (lambda Wilks P=.013) and baseline HDL-cholesterol levels (lambda Wilks P=.000) were the parameters that seem to be more relevant above the rest of the metabolic syndrome constituents diagnosis criteria as predictors in the long-term.
  
  
  CONCLUSIONS
  In the search for predictive factors of metabolic syndrome, HDL-cholesterol and abdominal circumference at the time of inclusion were selected, as such that the worst the baseline results were, the higher probability of long-term improvement.
authors.affiliation: Unidad de Hospitalización de Psiquiatría, Complejo Asistencial Universitario de León, León, España. Electronic address: clarafranch@hotmail.com.
authors.forename: Clara M
authors.initials: CM
authors.lastname: Franch Pato
authors.affiliation: Unidad de Hospitalización de Psiquiatría, Hospital Clínico Universitario, Valladolid, España.
authors.forename: Vicente
authors.initials: V
authors.lastname: Molina Rodríguez
authors.affiliation: Facultad de Enfermería, Universidad de Valladolid, Valladolid, España.
authors.forename: Juan I
authors.initials: JI
authors.lastname: Franch Valverde
mesh_terms: D000328:Adult; D000368:Aged; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D060046:Maintenance Chemotherapy; D008297:Male; D024821:Metabolic Syndrome / Q000139:chemically induced* / Q000175:diagnosis; D008875:Middle Aged; D011446:Prospective Studies; D011618:Psychotic Disorders / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents
keywords: Antipsicóticos atípicos; Atypical antipsychotic; Determining factors; Esquizofrenia; Factores determinantes; Metabolic syndrome; Psicoeducación; Psycho-education; Schizophrenia; Síndrome metabólico