title: HIV, HPV, and microbiota: partners in crime?
abstract: Altered interplay between gut mucosa and dysbiotic bacteria during HIV infection seems to fuel chronic immune dysfunction and might explain the excess rates of human papillomavirus (HPV)-associated anal cancer in HIV-infected individuals. Here, we show in HIV-infected MSM undergoing screening for HPV-related cancer that specific fecal and mucosal bacteria are able to predict the existence of precancerous anal lesions. If confirmed, these bacterial biomarkers could be exploited either as diagnostic tools or therapeutic targets.
authors.affiliation: aDepartment of Infectious Diseases, Hospital Universitario Ramón y Cajal, Facultad de Medicina, Universidad de Alcalá (IRYCIS), Madrid bUnidad Mixta de Investigación en Genómica y Salud de la Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (FISABIO-Salud Pública) y el Instituto Cavanilles de Biodiversidad y Biología Evolutiva (Universidad de Valencia), Valencia cDepartment of Pediatric Infectious Diseases, Hospital Universitario La Paz (IdiPAZ) dDepartment of Pathology, Hospital Universitario Ramón y Cajal eCIBER en Epidemiología y Salud Pública (CIBERESP), Madrid, Spain. *Santiago Moreno and María José Gosalbes contributed equally to this study.
authors.forename: Sergio
authors.initials: S
authors.lastname: Serrano-Villar
authors.forename: Emilia
authors.initials: E
authors.lastname: Vásquez-Domínguez
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Pérez-Molina
authors.forename: Talía
authors.initials: T
authors.lastname: Sainz
authors.forename: Amparo
authors.initials: A
authors.lastname: de Benito
authors.forename: Amparo
authors.initials: A
authors.lastname: Latorre
authors.forename: Andrés
authors.initials: A
authors.lastname: Moya
authors.forename: María José
authors.initials: MJ
authors.lastname: Gosalbes
authors.forename: Santiago
authors.initials: S
authors.lastname: Moreno
mesh_terms: D000328:Adult; D001005:Anus Neoplasms / Q000453:epidemiology* / Q000821:virology; D003430:Cross-Sectional Studies; D064806:Dysbiosis / Q000150:complications*; D000069196:Gastrointestinal Microbiome; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008297:Male; D064307:Microbiota; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000150:complications* / Q000453:epidemiology; D000072339:Sexual and Gender Minorities