title: Drug-Loaded Polymeric Spherical Nucleic Acids: Enhancing Colloidal Stability and Cellular Uptake of Polymeric Nanoparticles through DNA Surface-Functionalization.
abstract: Small-sized (∼65 nm) doxorubicin (Dox)-loaded polymeric nanoparticles (PNPs) were modified with oligonucleotides to form colloidally stable Dox-loaded polymeric spherical nucleic acid (Dox-PSNA) nanostructures in biological media. The nucleic acid shell facilitates the cellular uptake of Dox-PSNA, which results in in vitro cytotoxicity against SKOV3 cancer cells.
authors.affiliation: Department of Chemical and Biological Engineering, ‡Department of Biomedical Engineering, §Department of Chemistry, and ⊥International Institute of Nanotechnology, Northwestern University , 2145 Sheridan Road, Evanston, Illinois 60208-3113, United States.
authors.forename: Resham J
authors.initials: RJ
authors.lastname: Banga
authors.affiliation: Department of Chemical and Biological Engineering, ‡Department of Biomedical Engineering, §Department of Chemistry, and ⊥International Institute of Nanotechnology, Northwestern University , 2145 Sheridan Road, Evanston, Illinois 60208-3113, United States.
authors.forename: Sai Archana
authors.initials: SA
authors.lastname: Krovi
authors.affiliation: Department of Chemical and Biological Engineering, ‡Department of Biomedical Engineering, §Department of Chemistry, and ⊥International Institute of Nanotechnology, Northwestern University , 2145 Sheridan Road, Evanston, Illinois 60208-3113, United States.
authors.forename: Suguna P
authors.initials: SP
authors.lastname: Narayan
authors.affiliation: Department of Chemical and Biological Engineering, ‡Department of Biomedical Engineering, §Department of Chemistry, and ⊥International Institute of Nanotechnology, Northwestern University , 2145 Sheridan Road, Evanston, Illinois 60208-3113, United States.
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Sprangers
authors.affiliation: Department of Chemical and Biological Engineering, ‡Department of Biomedical Engineering, §Department of Chemistry, and ⊥International Institute of Nanotechnology, Northwestern University , 2145 Sheridan Road, Evanston, Illinois 60208-3113, United States.
authors.forename: Guoliang
authors.identifier: 0000-0002-6778-0625
authors.initials: G
authors.lastname: Liu
authors.affiliation: Department of Chemical and Biological Engineering, ‡Department of Biomedical Engineering, §Department of Chemistry, and ⊥International Institute of Nanotechnology, Northwestern University , 2145 Sheridan Road, Evanston, Illinois 60208-3113, United States.
authors.forename: Chad A
authors.identifier: 0000-0002-6634-7627
authors.initials: CA
authors.lastname: Mirkin
authors.affiliation: Department of Chemical and Biological Engineering, ‡Department of Biomedical Engineering, §Department of Chemistry, and ⊥International Institute of Nanotechnology, Northwestern University , 2145 Sheridan Road, Evanston, Illinois 60208-3113, United States.
authors.forename: SonBinh T
authors.identifier: 0000-0002-6977-3445
authors.initials: ST
authors.lastname: Nguyen
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D004247:DNA / Q000737:chemistry*; D004317:Doxorubicin / Q000008:administration & dosage / Q000494:pharmacology*; D004337:Drug Carriers / Q000737:chemistry*; D005260:Female; D006801:Humans; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D010051:Ovarian Neoplasms / Q000188:drug therapy*; D011108:Polymers / Q000737:chemistry*; D013499:Surface Properties; D014407:Tumor Cells, Cultured
chemical_list: D000903:Antibiotics, Antineoplastic; D004337:Drug Carriers; D011108:Polymers; D004317:Doxorubicin; D004247:DNA