title: Safety Assessment of Polyquaternium-22 and Polyquarternium-39 as Used in Cosmetics.
abstract: Polyquaternium-22 and polyquaternium-39 are polymers that function as antistatic agents, film formers, and hair fixatives in cosmetic products. These ingredients are being used at concentrations up to 2% (polyquaternium-22, in a rinse-off product) and up to 3% (polyquaternium-39, in rinse-off and leave-on products). The unreacted monomer content of these ingredients was considered low and of no toxicological concern. Limited data showed no skin irritation/sensitization. Although these ingredients were nongenotoxic in bacterial assays, mammalian genotoxicity, carcinogenicity, and reproductive and developmental toxicity data were not available. These polymers, however, are large, highly polar molecules that would likely not be absorbed, and neither local effects in the respiratory tract nor systemic toxicity are expected following product application/exposure. The Expert Panel concluded that polyquaternium-22 and polyquaternium-39 are safe in the present practices of use and concentration in cosmetic formulations.
authors.affiliation: Cosmetic Ingredient Review Scientific Analyst/Writer.
authors.forename: Wilbur
authors.initials: W
authors.lastname: Johnson
authors.affiliation: Cosmetic Ingredient Review Chemist.
authors.forename: Bart
authors.initials: B
authors.lastname: Heldreth
authors.affiliation: Cosmetic Ingredient Review Expert Panel Member.
authors.forename: Wilma F
authors.initials: WF
authors.lastname: Bergfeld
authors.affiliation: Cosmetic Ingredient Review Expert Panel Member.
authors.forename: Donald V
authors.initials: DV
authors.lastname: Belsito
authors.affiliation: Cosmetic Ingredient Review Expert Panel Member.
authors.forename: Ronald A
authors.initials: RA
authors.lastname: Hill
authors.affiliation: Cosmetic Ingredient Review Expert Panel Member.
authors.forename: Curtis D
authors.initials: CD
authors.lastname: Klaassen
authors.affiliation: Cosmetic Ingredient Review Expert Panel Member.
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Liebler
authors.affiliation: Cosmetic Ingredient Review Expert Panel Member.
authors.forename: James G
authors.initials: JG
authors.lastname: Marks
authors.affiliation: Cosmetic Ingredient Review Expert Panel Member.
authors.forename: Ronald C
authors.initials: RC
authors.lastname: Shank
authors.affiliation: Cosmetic Ingredient Review Expert Panel Member.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Slaga
authors.affiliation: Cosmetic Ingredient Review Expert Panel Member.
authors.forename: Paul W
authors.initials: PW
authors.lastname: Snyder
authors.affiliation: Former Director, Cosmetic Ingredient Review.
authors.forename: F Alan
authors.initials: FA
authors.lastname: Andersen
mesh_terms: D000818:Animals; D003257:Consumer Product Safety / Q000331:legislation & jurisprudence; D003358:Cosmetics / Q000737:chemistry / Q000592:standards*; D006801:Humans; D015394:Molecular Structure; D011108:Polymers / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity*; D013329:Structure-Activity Relationship; D018675:Toxicity Tests / Q000379:methods; D066007:Toxicokinetics; D014481:United States; D014486:United States Food and Drug Administration
chemical_list: D003358:Cosmetics; D011108:Polymers; D000644:Quaternary Ammonium Compounds; C000625934:polyquaternium-22; C000625935:polyquaternium-39
keywords: cosmetics; polyquarternium-39; polyquaternium-22; safety