title: Increased copeptin levels in metabolic syndrome from a Romanian population.
abstract: Rationale:Arginine vasopressin (AVP) is secreted under conditions of water deprivation. Since AVP has a low half-life in the plasma, the C-terminal fragment of AVP-precursor (copeptin) was used to estimate the AVP levels. High copeptin levels increase the risk for the development of diabetes mellitus.Aim:This study was aimed to measure copeptin levels in the metabolic syndrome (MetS) in Romanians using a competitive enzyme immunoassay.Methods and results:Patients prone to present MetS (n = 63) were compared to controls (n = 42). In the MetS group, the syndrome was confirmed in 93.6%. Affected patients displayed 85.7% obesity and insulin resistance (HOMAIR of 4.9 ± 0.4 versus 1.1 ± 0.8 in controls). Low HDL-cholesterol was less represented (47.5%). Copeptin levels were 0.6 ± 0.0 in MetS versus 0.42 ± 0.0 ng/ mL in controls (P < 0.004). Higher copeptin (0.79 to 1.83 ng/ mL) was associated with MetS, P < 0.0018, OR 20, 95%CI [3.03 - 131.7]. In ANOVA, high copeptin was equally explained by MetS or obesity (P < 0.05,α = 3.8). The best correlation was found with high triglyceride levels (P < 0.013,α = 6.3) while the correlation with HOMAIR remained not significant.Discussion:These data indicated a concordant correlation between increased copeptin and MetS or its components. In the light of epidemiological data, indicating that more than 50% of the European population has a lower daily water intake and a fraction of 25% displaying high copeptin, our data further sustained that copeptin may be a good biomarker for MetS and/ or obesity, which should be further investigated with other members of the osmoregulation pathway at both pathogenesis and genetic levels.
authors.affiliation: "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania ; "C.I. Parhon" National Institute of Endocrinology, Bucharest, Romania.
authors.forename: M
authors.initials: M
authors.lastname: Vintilă
authors.affiliation: "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania ; "C.I. Parhon" National Institute of Endocrinology, Bucharest, Romania.
authors.forename: M L
authors.initials: ML
authors.lastname: Gheorghiu
authors.affiliation: "C.I. Parhon" National Institute of Endocrinology, Bucharest, Romania.
authors.forename: A
authors.initials: A
authors.lastname: Caragheorgheopol
authors.affiliation: "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania ; "C.I. Parhon" National Institute of Endocrinology, Bucharest, Romania.
authors.forename: N
authors.initials: N
authors.lastname: Baculescu
authors.affiliation: University of Medicine and Pharmacy Craiova, Romania.
authors.forename: C
authors.initials: C
authors.lastname: Lichiardopol
authors.affiliation: "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania ; "C.I. Parhon" National Institute of Endocrinology, Bucharest, Romania.
authors.forename: C
authors.initials: C
authors.lastname: Badiu
authors.affiliation: Passed away in March 2016 ; "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania ; "C.I. Parhon" National Institute of Endocrinology, Bucharest, Romania.
authors.forename: M
authors.initials: M
authors.lastname: Coculescu
authors.affiliation: Laboratory of Molecular Endocrinology, IURC, UMR204, NUTRIPASS (IRD, University of Montpellier, SuprAgro).
authors.forename: F
authors.initials: F
authors.lastname: Grigorescu
authors.affiliation: "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania ; "C.I. Parhon" National Institute of Endocrinology, Bucharest, Romania.
authors.forename: C
authors.initials: C
authors.lastname: Poiană
mesh_terms: D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D006020:Glycopeptides / Q000097:blood*; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood*; D008875:Middle Aged; D012383:Romania
chemical_list: D015415:Biomarkers; D006020:Glycopeptides; C048197:copeptins
keywords: arginine vasopressin; copeptin; insulin resistance; metabolic syndrome