title: Protective effects of green tea and its main constituents against natural and chemical toxins: A comprehensive review.
abstract: Toxins are natural or chemical poisonous substances with severe side effects on health. Humans are generally exposed by widespread toxic contaminations via air, soil, water, food, fruits and vegetables. Determining a critical antidote agent with extensive effects on different toxins is an ultimate goal for all toxicologists. Traditional medicine is currently perceived as a safe and natural approach against toxins. In this regard, we focused on the protective effects of green tea (Camellia sinensis) and its main components such as catechin, epicatechin, epicatechin gallate, gallocatechin, epigallocatechin and epigallocatechin gallate as a principal source of antioxidants against both natural and chemical toxins. This literate review demonstrates that protective effects of green tea and its constituents were mainly attributed to their anti-oxidative, radical scavenging, chelating, anti-apoptotic properties and modulating inflammatory responses. Although, some studies reveal they have protective effects by increasing toxin metabolism and neutralizing PLA2, proteases, hyaluronidase and l-amino acid oxidase enzymes.
authors.affiliation: Pharmaceutical Research Center, Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: mrameshrad@gmail.com.
authors.forename: Maryam
authors.initials: M
authors.lastname: Rameshrad
authors.affiliation: Targeted Drug Delivery Research Center, Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: RazaviMr@mums.ac.ir.
authors.forename: Bibi Marjan
authors.initials: BM
authors.lastname: Razavi
authors.affiliation: Pharmaceutical Research Center, Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: hosseinzadehh@mums.ac.ir.
authors.forename: Hossein
authors.initials: H
authors.lastname: Hosseinzadeh
mesh_terms: D002318:Cardiovascular Diseases / Q000139:chemically induced / Q000517:prevention & control*; D006801:Humans; D019636:Neurodegenerative Diseases / Q000139:chemically induced / Q000517:prevention & control*; D010936:Plant Extracts / Q000494:pharmacology*; D013662:Tea / Q000737:chemistry*; D014118:Toxins, Biological / Q000009:adverse effects*
chemical_list: D010936:Plant Extracts; D013662:Tea; D014118:Toxins, Biological
keywords: Antidote; Camellia sinensis; Epigallocatechin gallate; Green tea; Protective; Toxin