title: Soluble Tumor Necrosis Factor Receptors and Arterial Stiffness in Patients With Coronary Atherosclerosis.
abstract: BACKGROUND
  Soluble forms of tumor necrosis factor receptors (sTNFRs) are emerging target molecules of inflammatory disease. However, their role in vascular biology is not well known. This study was performed to investigate the association between serum concentrations of sTNFRs and arterial stiffness.
  
  
  METHODS
  A total of 117 consecutive patients with suspected coronary artery disease (CAD) (63.6 ± 11.0 years; men, 65%) who were referred for invasive coronary angiography (ICA) were prospectively enrolled. Arterial blood sTNFR1 and sTNFR2 were measured using commercially available ELISA kits. Brachial-ankle pulse wave velocity (baPWV) measurements were made within 24 hours of blood sampling for sTNFRs measurement.
  
  
  RESULTS
  Most of the patients (86.3%) had significant CAD (stenosis ≥ 50%) in ICA. In simple linear regression analyses, there were significant positive correlations of baPWV with sTNFR1 (r = 0.483, P < 0.001) and sTNFR2 (r = 0.366, P < 0.001). In multiple linear regression analyses, sTNFR1 (β = 0.316, P < 0.001) and sTNFR2 (β = 0.235, P = 0.005) had independent association with baPWV even after controlling for potential confounders.
  
  
  CONCLUSIONS
  sTNFR1 and sTNFR2 were independently associated with baPWV in patients undergoing ICA. This result may extend previous knowledge on close interactions between inflammation and arterial stiffening.
authors.affiliation: Department of Internal Medicine, Boramae Medical Center, Seoul, Korea.|Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Hack-Lyoung
authors.initials: HL
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Boramae Medical Center, Seoul, Korea.|Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Jung Pyo
authors.initials: JP
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Boramae Medical Center, Seoul, Korea.|Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Jung Nam
authors.initials: JN
authors.lastname: An
authors.affiliation: Department of Internal Medicine, Boramae Medical Center, Seoul, Korea.
authors.forename: Jin Hyuk
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Boramae Medical Center, Seoul, Korea.|Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Woo-Hyun
authors.initials: WH
authors.lastname: Lim
authors.affiliation: Department of Internal Medicine, Boramae Medical Center, Seoul, Korea.|Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Jae-Bin
authors.initials: JB
authors.lastname: Seo
authors.affiliation: Department of Internal Medicine, Boramae Medical Center, Seoul, Korea.|Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Woo-Young
authors.initials: WY
authors.lastname: Chung
authors.affiliation: Department of Internal Medicine, Boramae Medical Center, Seoul, Korea.|Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Yoon Kyu
authors.initials: YK
authors.lastname: Oh
authors.affiliation: Seoul National University College of Medicine, Seoul, Korea.|Seoul National University Kidney Research Institute, Seoul, Korea.|Department of Medical Science, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Yon Su
authors.initials: YS
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Boramae Medical Center, Seoul, Korea.|Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Chun Soo
authors.initials: CS
authors.lastname: Lim
authors.affiliation: Department of Internal Medicine, Boramae Medical Center, Seoul, Korea.|Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Joo-Hee
authors.initials: JH
authors.lastname: Zo
authors.affiliation: Department of Internal Medicine, Boramae Medical Center, Seoul, Korea.|Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Myung-A
authors.initials: MA
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Boramae Medical Center, Seoul, Korea.|Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Sang-Hyun
authors.initials: SH
authors.lastname: Kim
mesh_terms: D000368:Aged; D055109:Ankle Brachial Index; D002097:C-Reactive Protein / Q000032:analysis; D003324:Coronary Artery Disease / Q000097:blood* / Q000453:epidemiology / Q000503:physiopathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009504:Neutrophils; D011446:Prospective Studies; D063177:Pulse Wave Analysis; D018124:Receptors, Tumor Necrosis Factor / Q000097:blood*; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000097:blood; D047889:Receptors, Tumor Necrosis Factor, Type II / Q000097:blood; D012307:Risk Factors; D059289:Vascular Stiffness
chemical_list: D018124:Receptors, Tumor Necrosis Factor; D047888:Receptors, Tumor Necrosis Factor, Type I; D047889:Receptors, Tumor Necrosis Factor, Type II; D002097:C-Reactive Protein
keywords: arterial stiffness; blood pressure; hypertension; inflammation; pulse wave velocity; soluble tumor necrosis factor receptor