title: Family PArtners in Lifestyle Support (PALS): Family-based weight loss for African American adults with type 2 diabetes.
abstract: To develop and test a family-centered behavioral weight loss intervention for African American adults with type 2 diabetes.
  
  
  
  In this randomized trial, dyads consisting of an African American adult with overweight or obesity and type 2 diabetes (index participant) paired with a family partner with overweight or obesity but not diagnosed with diabetes were assigned in a 2:1 ratio to a 20-week special intervention (SI) or delayed intervention (DI) control group. The primary outcome was weight loss among index participants at the 20-week follow-up.
  
  
  
  One hundred eight participants (54 dyads-36 (SI) and 18 (DI) dyads) were enrolled: 81% females; mean age, 51 years; mean weight,103 kg; and mean BMI, 37 kg/m2. At post-intervention, 96 participants (89%) returned for follow-up measures. Among index participants, mean difference in weight loss between groups was -5.0 kg, P <0.0001 (-3.6 kg loss among SI; 1.4 kg gain in DI). SI index participants showed significantly greater improvements in hemoglobin A1c, depressive symptoms, family interactions, and dietary, physical activity, and diabetes self-care behaviors. SI family partners also had significant weight loss (-3.9 kg (SI) vs. -1.0 kg (DI), P = 0.02).
  
  
  
  A family-centered, behavioral weight loss intervention led to clinically significant short-term weight loss among family dyads.
authors.affiliation: Department of Nutrition, Gillings School of Global Public Health, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.|Center for Health Promotion and Disease Prevention, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
authors.forename: Carmen D
authors.initials: CD
authors.lastname: Samuel-Hodge
authors.affiliation: Department of Psychiatry and Behavioral Science, Duke University, Durham, North Carolina, USA.|Department of Community and Family Medicine, Duke University, Durham, North Carolina, USA.
authors.forename: Judith C
authors.initials: JC
authors.lastname: Holder-Cooper
authors.affiliation: Center for Health Promotion and Disease Prevention, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
authors.forename: Ziya
authors.initials: Z
authors.lastname: Gizlice
authors.affiliation: Center for Health Promotion and Disease Prevention, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
authors.forename: Gwendolyn
authors.initials: G
authors.lastname: Davis
authors.affiliation: Center for Health Promotion and Disease Prevention, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
authors.forename: Sonia P
authors.initials: SP
authors.lastname: Steele
authors.affiliation: Center for Health Promotion and Disease Prevention, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.|Department of General Internal Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Keyserling
authors.affiliation: Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
authors.forename: Shiriki K
authors.initials: SK
authors.lastname: Kumanyika
authors.affiliation: Behavioral Medicine Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA.
authors.forename: Phillip J
authors.initials: PJ
authors.lastname: Brantley
authors.affiliation: Department of Medicine, Division of Nephrology, Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina, USA.
authors.forename: Laura P
authors.initials: LP
authors.lastname: Svetkey
mesh_terms: D000328:Adult; D001741:Black or African American / Q000523:psychology / Q000706:statistics & numerical data*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000208:ethnology* / Q000517:prevention & control*; D005195:Family Relations; D005260:Female; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000208:ethnology* / Q000517:prevention & control*; D012944:Social Support; D015431:Weight Loss