title: Inflammatory Cytokine Levels After Endovascular Therapy in Patients With Peripheral Artery Disease.
abstract: We evaluated the impact of endovascular therapy (EVT) on inflammatory cytokine levels and its relationship with in-stent restenosis in patients with peripheral artery disease. The study prospectively enrolled 35 patients with intermittent claudication who underwent EVT of the iliofemoral artery. Levels of interleukin 6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), and tumor necrosis factor α (TNF-α) were measured using enzyme-linked immunosorbent assay before and at 2 hours, 4 hours, and 3 months after EVT. All cytokine levels increased significantly after EVT (IL-6 [pg/mL]: from 1.51 [0.84-1.93] before EVT to 6.97 [4.05-20.41] at 2 hours and 13.29 [4.57-31.88] at 4 hours; MCP-1 [pg/mL]: from 326.65 [265.60-406.55] before EVT to 411.18 [341.21-566.27] at 2 hours and 519.36 [383.58-644.85] at 4 hours; TNF-α [pg/mL]: from 1.08 [0.77-1.29] before EVT to 1.25 [0.94-1.81] at 2 hours and 1.27 [0.95-1.59] at 4 hours, all P < .001). However, cytokine levels did not differ significantly between lesions with and without in-stent restenosis. Overall, our results suggest that EVT significantly increases IL-6, MCP-1, and TNF-α levels in the ischemic leg, but this effect is not associated with a higher rate of in-stent restenosis.
authors.affiliation: 1 Department of Cardiovascular Medicine, Shinshu University, School of Medicine, Matsumoto, Nagano, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Ueki
authors.affiliation: 1 Department of Cardiovascular Medicine, Shinshu University, School of Medicine, Matsumoto, Nagano, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Miura
authors.affiliation: 1 Department of Cardiovascular Medicine, Shinshu University, School of Medicine, Matsumoto, Nagano, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Miyashita
authors.affiliation: 1 Department of Cardiovascular Medicine, Shinshu University, School of Medicine, Matsumoto, Nagano, Japan.
authors.forename: Souichiro
authors.initials: S
authors.lastname: Ebisawa
authors.affiliation: 1 Department of Cardiovascular Medicine, Shinshu University, School of Medicine, Matsumoto, Nagano, Japan.
authors.forename: Hirohiko
authors.initials: H
authors.lastname: Motoki
authors.affiliation: 1 Department of Cardiovascular Medicine, Shinshu University, School of Medicine, Matsumoto, Nagano, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Izawa
authors.affiliation: 1 Department of Cardiovascular Medicine, Shinshu University, School of Medicine, Matsumoto, Nagano, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Koyama
authors.affiliation: 1 Department of Cardiovascular Medicine, Shinshu University, School of Medicine, Matsumoto, Nagano, Japan.
authors.forename: Uichi
authors.initials: U
authors.lastname: Ikeda
mesh_terms: D000368:Aged; D055109:Ankle Brachial Index; D018932:Chemokine CCL2 / Q000097:blood*; D057510:Endovascular Procedures; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006083:Graft Occlusion, Vascular / Q000097:blood*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D058729:Peripheral Arterial Disease / Q000000981:diagnostic imaging / Q000628:therapy*; D011446:Prospective Studies; D015607:Stents; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D018932:Chemokine CCL2; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha
keywords: cytokine; endovascular therapy; interleukin 6; peripheral artery disease