title: HSD2 neurons in the hindbrain drive sodium appetite.
abstract: Sodium-depleted animals develop an appetite for aversive concentrations of sodium. Here we show that chemogenetic activation of aldosterone-sensitive neurons that express 11β-hydroxysteroid dehydrogenase type 2 (HSD2) in the nucleus of the solitary tract is sufficient to drive consumption of sodium-containing solutions in mice, independently of thirst or hunger. These HSD2-positive neurons are necessary for full expression of sodium appetite and have distinct downstream targets that are activated during sodium depletion.
authors.affiliation: Department of Biochemistry, University of Washington, Seattle, Washington, USA.
authors.forename: Brooke C
authors.initials: BC
authors.lastname: Jarvie
authors.affiliation: Department of Biochemistry, University of Washington, Seattle, Washington, USA.|Howard Hughes Medical Institute, University of Washington, Seattle, Washington, USA.
authors.forename: Richard D
authors.initials: RD
authors.lastname: Palmiter
mesh_terms: D043209:11-beta-Hydroxysteroid Dehydrogenase Type 2 / Q000235:genetics*; D000450:Aldosterone / Q000378:metabolism; D000818:Animals; D001066:Appetite / Q000502:physiology*; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009474:Neurons / Q000201:enzymology*; D012249:Rhombencephalon / Q000201:enzymology*; D012982:Sodium, Dietary / Q000378:metabolism*; D013894:Thirst / Q000502:physiology
chemical_list: D012982:Sodium, Dietary; D000450:Aldosterone; D043209:11-beta-Hydroxysteroid Dehydrogenase Type 2