title: [RETpro-oncogene and medullary thyroid carcinoma].
abstract: Medullary thyroid carcinoma (MTC) originats from the parafollicular C cells of the thyroid, which is one of the most aggressive forms of thyroid malignancy with the poor prognosis. Hereditary MTC has multiple endocrine neoplasia types 1, 2A and 2B. The mutation ofRETproto-oncogene has been identified as the main cause of MTC, and all mutations locate among the exons 5, 8, 10, 11, 13, 14, 15, and 16. Mutation analysis of theRETmay provide a theoretical basis for the prevention, diagnosis and treatment of MTC.
authors.affiliation: Department of Etiology and Biomarker Detection, Shanxi Cancer Institute, Taiyuan 030013, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Etiology and Biomarker Detection, Shanxi Cancer Institute, Taiyuan 030013, China.
authors.forename: L L
authors.initials: LL
authors.lastname: Du
authors.affiliation: Department of Anal and Colotectal Surgery, Shanxi Cancer Institute, Taiyuan 030013, China.
authors.forename: S H
authors.initials: SH
authors.lastname: Hou
authors.affiliation: Department of Etiology and Biomarker Detection, Shanxi Cancer Institute, Taiyuan 030013, China.
authors.forename: C Z
authors.initials: CZ
authors.lastname: Han
authors.affiliation: Department of Etiology and Biomarker Detection, Shanxi Cancer Institute, Taiyuan 030013, China.
authors.forename: X W
authors.initials: XW
authors.lastname: Zhao
authors.affiliation: Department of Etiology and Biomarker Detection, Shanxi Cancer Institute, Taiyuan 030013, China.
authors.forename: W G
authors.initials: WG
authors.lastname: Wang
authors.affiliation: Department of Etiology and Biomarker Detection, Shanxi Cancer Institute, Taiyuan 030013, China.
authors.forename: X Q
authors.initials: XQ
authors.lastname: Xu
authors.affiliation: Department of Etiology and Biomarker Detection, Shanxi Cancer Institute, Taiyuan 030013, China.
authors.forename: J X
authors.initials: JX
authors.lastname: Jing
mesh_terms: D018278:Carcinoma, Neuroendocrine / Q000235:genetics* / Q000473:pathology; D004252:DNA Mutational Analysis; D005091:Exons; D006801:Humans; D009154:Mutation; D016133:Polymerase Chain Reaction; D000090063:Proto-Oncogene Mas; D051096:Proto-Oncogene Proteins c-ret / Q000235:genetics*; D013964:Thyroid Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D051096:Proto-Oncogene Proteins c-ret