title: [18F]-Fluoride capture and release: azeotropic drying free nucleophilic aromatic radiofluorination assisted by a phosphonium borane.
abstract: [18F]-Fluoride ready for aromatic nucleophilic substitution was prepared according to a simple process including trapping of aqueous [18F]-fluoride on a cartridge pre-loaded with the phosphonium borane [(Ph2MeP)C6H4(BMes2)]+, then releasing by elution of TBACN in dry acetonitrile. Subsequent radiofluorination was successfully applied to a model reaction and to the radiosynthesis of [18F]-setoperone.
authors.affiliation: Normandie Univ, UNICAEN, CEA, CNRS, UMR6301-ISTCT, LDM-TEP, Cyceron, Boulevard Henri Becquerel, 14000 Caen, France. perrio@cyceron.fr.
authors.forename: Cécile
authors.initials: C
authors.lastname: Perrio
authors.affiliation: Normandie Univ, UNICAEN, CEA, CNRS, UMR6301-ISTCT, LDM-TEP, Cyceron, Boulevard Henri Becquerel, 14000 Caen, France. perrio@cyceron.fr.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Schmitt
authors.affiliation: LCC, CNRS, UPR8241, UFTMP, 205, route de Narbonne, BP 44099, 31077 Toulouse Cedex 4, France. emmanuel.gras@lcc-toulouse.fr.
authors.forename: Daniel
authors.identifier: 0000-0002-8703-8778
authors.initials: D
authors.lastname: Pla
authors.affiliation: Department of Chemistry, Texas A&M University, College Station, Texas 77843, USA.
authors.forename: François P
authors.identifier: 0000-0003-4788-2998
authors.initials: FP
authors.lastname: Gabbaï
authors.affiliation: Department of Chemistry, Texas A&M University, College Station, Texas 77843, USA.
authors.forename: Kantapat
authors.initials: K
authors.lastname: Chansaenpak
authors.affiliation: LCC, CNRS, UPR8241, UFTMP, 205, route de Narbonne, BP 44099, 31077 Toulouse Cedex 4, France. emmanuel.gras@lcc-toulouse.fr.
authors.forename: Béatrice
authors.initials: B
authors.lastname: Mestre-Voegtle
authors.affiliation: LCC, CNRS, UPR8241, UFTMP, 205, route de Narbonne, BP 44099, 31077 Toulouse Cedex 4, France. emmanuel.gras@lcc-toulouse.fr.
authors.forename: Emmanuel
authors.identifier: 0000-0002-1178-3579
authors.initials: E
authors.lastname: Gras
mesh_terms: D000097:Acetonitriles / Q000737:chemistry; D001880:Boranes / Q000737:chemistry*; D005459:Fluorides / Q000737:chemistry*; D005462:Fluorine Radioisotopes / Q000737:chemistry*; D054879:Halogenation; D011854:Radiochemistry / Q000379:methods*
chemical_list: D000097:Acetonitriles; D001880:Boranes; D005462:Fluorine Radioisotopes; D005459:Fluorides; C032159:acetonitrile