title: The injury of fine particulate matter from cooking oil fumes on umbilical cord blood vessels in vitro.
abstract: Cooking oil fumes (COFs) derived PM2.5is the major source of indoor air pollution in Asia. For this, a pregnant rat model within different doses of cooking oil fumes (COFs) derived PM2.5was established in pregnancy in our research. Our previous studies have showed that exposure to COFs-derived PM2.5was related to adverse pregnancy outcomes. However, the mechanisms of signaling pathways remain unknown. Therefore, this study aimed to investigate the underlying mechanisms induced by COFs-derived PM2.5 injury on umbilical cord blood vessels (UCs) in vitro. Exposure to COFs-derived PM2.5resulted in changing the expression of eNOS, ET-1, ETRA, and ETRB. In additions, western blot analysis indicated that the HIF-1α/iNOS/NO signaling pathway and VEGF/VEGFR1/iNOS signaling pathway were involved in UCs injury triggered by COFs-derived PM2.5. In conclusion, our data suggested that exposure to COFs-derived PM2.5resulted in increasing of oxidative stress and inflammation, as well as dysfunction of UCs.
authors.affiliation: Department of Occupational and Environmental, School of Public Health, Anhui Medical University, Meishan Road, Hefei, Anhui, China.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Hou
authors.affiliation: Department of Occupational and Environmental, School of Public Health, Anhui Medical University, Meishan Road, Hefei, Anhui, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Occupational and Environmental, School of Public Health, Anhui Medical University, Meishan Road, Hefei, Anhui, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Occupational and Environmental, School of Public Health, Anhui Medical University, Meishan Road, Hefei, Anhui, China.
authors.forename: Yachun
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Occupational and Environmental, School of Public Health, Anhui Medical University, Meishan Road, Hefei, Anhui, China.
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Zhu
authors.affiliation: Department of Occupational and Environmental, School of Public Health, Anhui Medical University, Meishan Road, Hefei, Anhui, China.
authors.forename: Cijiang
authors.initials: C
authors.lastname: Yao
authors.affiliation: Department of Occupational and Environmental, School of Public Health, Anhui Medical University, Meishan Road, Hefei, Anhui, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Occupational and Environmental, School of Public Health, Anhui Medical University, Meishan Road, Hefei, Anhui, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.affiliation: The Teaching Center for Preventive Medicine, School of Public Health, Anhui Medical University, Meishan Road 81, Anhui Province, Postal Code 230032, Hefei, Anhui, China. Electronic address: qshq@163.com.
authors.forename: Jiyu
authors.initials: J
authors.lastname: Cao
mesh_terms: D000393:Air Pollutants / Q000633:toxicity*; D000818:Animals; D001808:Blood Vessels / Q000187:drug effects* / Q000378:metabolism; D003296:Cooking; D019332:Endothelin-1 / Q000378:metabolism; D005260:Female; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008431:Maternal-Fetal Exchange; D009569:Nitric Oxide / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D052638:Particulate Matter / Q000633:toxicity*; D000074241:Peanut Oil; D010938:Plant Oils / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D017382:Reactive Oxygen Species / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D014470:Umbilical Cord / Q000098:blood supply*
chemical_list: D000393:Air Pollutants; D019332:Endothelin-1; D015850:Interleukin-6; D052638:Particulate Matter; D000074241:Peanut Oil; D010938:Plant Oils; D017382:Reactive Oxygen Species; D014409:Tumor Necrosis Factor-alpha; D009569:Nitric Oxide; D013482:Superoxide Dismutase
keywords: Cooking oil fumes; HIF-1α and VEGF; PM(2.5); Umbilical cord blood vessels