title: Auditory evoked potential could reflect emotional sensitivity and impulsivity.
abstract: Emotional sensitivity and impulsivity could cause interpersonal conflicts and neuropsychiatric problems. Serotonin is correlated with behavioral inhibition and impulsivity. This study evaluated whether the loudness dependence of auditory evoked potential (LDAEP), a potential biological marker of central serotonergic activity, could reflect emotional sensitivity and impulsivity. A total of 157 healthy individuals were recruited, who performed LDAEP and Go/Nogo paradigms during electroencephalogram measurement. Barratt impulsivity scale (BIS), Conners' Adult ADHD rating scale (CAARS), and affective lability scale (ALS) were evaluated. Comparison between low and high LDAEP groups was conducted for behavioural, psychological, and event-related potential (ERP) measures. The high LDAEP group showed significantly increased BIS, a subscale of the CAARS, ALS, and false alarm rate of Nogo stimuli compared to the low LDAEP group. LDAEP showed significant positive correlations with the depression scale, ALS scores, subscale of the CAARS and Nogo-P3 amplitude. In the source activity of Nogo-P3, the cuneus, lingual gyrus, and precentral gyrus activities were significantly increased in the high LDAEP group. Our study revealed that LDAEP could reflect emotional sensitivity and impulsivity. LDAEP, an auditory evoked potential could be a useful tool to evaluate emotional regulation.
authors.affiliation: Clinical Emotion and Cognition Research Laboratory, Inje University, Goyang, Republic of Korea.
authors.forename: Ji Sun
authors.initials: JS
authors.lastname: Kim
authors.affiliation: Clinical Emotion and Cognition Research Laboratory, Inje University, Goyang, Republic of Korea.|Department of Biomedical Engineering, Hanyang University, Seoul, Republic of Korea.
authors.forename: Sungkean
authors.initials: S
authors.lastname: Kim
authors.affiliation: Clinical Emotion and Cognition Research Laboratory, Inje University, Goyang, Republic of Korea.
authors.forename: Wookyoung
authors.initials: W
authors.lastname: Jung
authors.affiliation: Department of Biomedical Engineering, Hanyang University, Seoul, Republic of Korea.
authors.forename: Chang-Hwan
authors.initials: CH
authors.lastname: Im
authors.affiliation: Clinical Emotion and Cognition Research Laboratory, Inje University, Goyang, Republic of Korea.|Department of Psychiatry, Inje University, Ilsan-Paik Hospital, Goyang, Republic of Korea.
authors.forename: Seung-Hwan
authors.initials: SH
authors.lastname: Lee
mesh_terms: D000328:Adult; D003865:Major Depressive Disorder; D004569:Electroencephalography; D004644:Emotions / Q000502:physiology*; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006801:Humans; D007175:Impulsive Behavior / Q000502:physiology*; D008144:Loudness Perception / Q000502:physiology*; D008297:Male; D011569:Psychiatric Status Rating Scales; D012701:Serotonin / Q000378:metabolism; D013315:Stress, Psychological / Q000503:physiopathology
chemical_list: D012701:Serotonin