title: The Neurobiology of Zika Virus.
abstract: Zika virus (ZIVK) represents a new threat to global health, with particular relevance to neuroscientists, due to associated newborn and adult neurological disease. Consequences of vertical infection include microcephaly with brain and eye anomalies, and consequences of adult infection include Guillain-Barré syndrome (GBS) and meningoencephalitis. Recent data suggest specific vulnerability of neural progenitors to infection, leading to cell death and brain calcification, reminiscent of other viral syndromes. Prevailing models suggest entry into neuronal stem cells through transmembrane receptors, hijacking cellular signaling to interfere with neurogenesis and cell survival. Mechanisms of adult neurological disease are unknown, but recent evidence suggests propensity for infection of adult neural stem cells. Efforts focused on mechanisms of pathogenesis, vulnerabilities, and treatments are urgently needed.
authors.affiliation: Laboratory for Pediatric Brain Disease, The Rockefeller University, New York, NY 10065, USA; Howard Hughes Medical Institute, Rady Children's Institute of Genomic Medicine, Department of Neurosciences, University of California San Diego, La Jolla, CA 92093, USA.
authors.forename: Hongda
authors.initials: H
authors.lastname: Li
authors.affiliation: Laboratory for Pediatric Brain Disease, The Rockefeller University, New York, NY 10065, USA; Howard Hughes Medical Institute, Rady Children's Institute of Genomic Medicine, Department of Neurosciences, University of California San Diego, La Jolla, CA 92093, USA.
authors.forename: Laura
authors.initials: L
authors.lastname: Saucedo-Cuevas
authors.affiliation: La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.
authors.forename: Sujan
authors.initials: S
authors.lastname: Shresta
authors.affiliation: Laboratory for Pediatric Brain Disease, The Rockefeller University, New York, NY 10065, USA; Howard Hughes Medical Institute, Rady Children's Institute of Genomic Medicine, Department of Neurosciences, University of California San Diego, La Jolla, CA 92093, USA. Electronic address: jogleeson@ucsd.edu.
authors.forename: Joseph G
authors.initials: JG
authors.lastname: Gleeson
mesh_terms: D001766:Blindness / Q000503:physiopathology / Q000821:virology; D001921:Brain / Q000276:immunology / Q000503:physiopathology* / Q000821:virology; D002470:Cell Survival; D060825:Cognitive Dysfunction / Q000503:physiopathology / Q000821:virology; D005260:Female; D020275:Guillain-Barre Syndrome / Q000276:immunology / Q000503:physiopathology* / Q000821:virology; D006801:Humans; D007231:Infant, Newborn; D007372:Interferons / Q000276:immunology; D008590:Meningoencephalitis / Q000276:immunology / Q000503:physiopathology* / Q000821:virology; D008831:Microcephaly / Q000276:immunology / Q000503:physiopathology* / Q000821:virology; D058953:Neural Stem Cells / Q000821:virology*; D055495:Neurogenesis / Q000502:physiology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology / Q000503:physiopathology* / Q000821:virology; D055351:Retinal Neurons / Q000821:virology; D000071244:Zika Virus / Q000472:pathogenicity* / Q000502:physiology; D000071243:Zika Virus Infection / Q000276:immunology / Q000503:physiopathology* / Q000821:virology
chemical_list: D007372:Interferons
keywords: Guillain-Barré syndrome; Zika; acute flaccid paralysis; antibody-mediated enhancement; flavivirus; interferon; microcephaly; neurovirology; vertical transmission