title: Endodontic Microbiology and Pathobiology: Current State of Knowledge.
abstract: Newer research tools and basic science knowledge base have allowed the exploration of endodontic diseases in the pulp and periapical tissues in novel ways. The use of next generation sequencing, bioinformatics analyses, genome-wide association studies, to name just a few of these innovations, has allowed the identification of hundreds of microorganisms and of host response factors. This review addresses recent advances in endodontic microbiology and the host response and discusses the potential for future innovations in this area.
authors.affiliation: Department of Endodontics, School of Dentistry, University of North Carolina at Chapel Hill, 1098 First Dental Building, CB# 7450, Chapel Hill, NC 27599-7450, USA. Electronic address: afouad@unc.edu.
authors.forename: Ashraf F
authors.initials: AF
authors.lastname: Fouad
mesh_terms: D035843:Biomedical Research; D003788:Dental Pulp Diseases / Q000382:microbiology*; D006801:Humans; D010483:Periapical Diseases / Q000382:microbiology*
keywords: Endodontic microbiology; Genetic polymorphism; Healing; Immunology; Stem cells; Systemic diseases