title: Chikungunya Virus Vaccines: Viral Vector-Based Approaches.
abstract: In 2013, a major chikungunya virus (CHIKV) epidemic reached the Americas. In the past 2 years, >1.7 million people have been infected. In light of the current epidemic, with millions of people in North and South America at risk, efforts to rapidly develop effective vaccines have increased. Here, we focus on CHIKV vaccines that use viral-vector technologies. This group of vaccine candidates shares an ability to potently induce humoral and cellular immune responses by use of highly attenuated and safe vaccine backbones. So far, well-described vectors such as modified vaccinia virus Ankara, complex adenovirus, vesicular stomatitis virus, alphavirus-based chimeras, and measles vaccine Schwarz strain (MV/Schw) have been described as potential vaccines. We summarize here the recent data on these experimental vaccines, with a focus on the preclinical and clinical activities on the MV/Schw-based candidate, which is the first CHIKV-vectored vaccine that has completed a clinical trial.
authors.affiliation: Themis Bioscience, Vienna, Austria.
authors.forename: Katrin
authors.initials: K
authors.lastname: Ramsauer
authors.affiliation: Viral Genomics and Vaccination Unit, CNRS UMR 3569, Institut Pasteur, Paris, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Tangy
mesh_terms: D000256:Adenoviridae / Q000235:genetics; D000569:Americas / Q000453:epidemiology; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D065632:Chikungunya Fever / Q000453:epidemiology / Q000276:immunology* / Q000517:prevention & control* / Q000821:virology; D002646:Chikungunya virus / Q000235:genetics* / Q000276:immunology*; D002986:Clinical Trials as Topic; D006801:Humans; D007111:Immunity, Cellular; D056724:Immunity, Humoral; D008458:Measles Vaccine / Q000235:genetics; D013020:South America / Q000453:epidemiology; D014614:Vaccines, Synthetic / Q000276:immunology; D014616:Vaccinia virus / Q000235:genetics; D014765:Viral Vaccines / Q000235:genetics* / Q000276:immunology*; D014780:Viruses / Q000235:genetics* / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D008458:Measles Vaccine; D014614:Vaccines, Synthetic; D014765:Viral Vaccines
keywords: MVA; VSV; adenovirus vector; chikungunya virus; measles virus vector; vaccine; viral vectors