title: Role of Mdm2 and Mdmx in DNA repair.
abstract: Mdm2 and Mdmx are critical regulators of the p53 tumour suppressor and are overexpressed in many human malignancies. However, in recent years, their impact on genome instability was shown to be at least, in part, independent of p53. Both Mdm2 and Mdmx inhibit DNA break repair through their association with the Mre11/Rad50/Nbs1 DNA repair complex. Recent evidence indicates that harnessing Mdm2 and/or Mdmx-mediated inhibition of DNA break repair in cancer cells could provide a therapeutic opportunity, particularly for those malignancies that have lost functional p53.
authors.affiliation: Department of Cancer Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA19107, USA.
authors.forename: Christine M
authors.initials: CM
authors.lastname: Eischen
mesh_terms: D000818:Animals; D004260:DNA Repair; D042822:Genomic Instability; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000378:metabolism / Q000628:therapy; D051736:Proto-Oncogene Proteins c-mdm2 / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D016159:Tumor Suppressor Protein p53; D051736:Proto-Oncogene Proteins c-mdm2
keywords: DNA repair; Mdm2; Mdmx; Nbs1