title: Severe paediatric conditions linked with EV-A71 and EV-D68, France, May to October 2016.
abstract: We report 59 cases of severe paediatric conditions linked with enterovirus (EV)-A71 and EV-D68 in France between May and October 2016. Fifty-two children had severe neurological symptoms. EV sequence-based typing for 42 cases revealed EV-A71 in 21 (18 subgenotype C1, detected for the first time in France) and EV-D68 in eight. Clinicians should be encouraged to obtain stool and respiratory specimens from patients presenting with severe neurological disorders for EV detection and characterisation.
authors.affiliation: Direction des maladies infectieuses, Santé publique France, Saint-Maurice, France.
authors.forename: Denise
authors.initials: D
authors.lastname: Antona
authors.affiliation: Service de neuropédiatrie, AP-HP, Hôpital Necker - Enfants malades, Paris, France.
authors.forename: Manoëlle
authors.initials: M
authors.lastname: Kossorotoff
authors.affiliation: CNR des entérovirus et parechovirus, laboratoire de virologie, Hospices civils de Lyon, Lyon, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Schuffenecker
authors.affiliation: CNR des entérovirus et parechovirus-laboratoire associé, laboratoire de virologie, CHU de Clermont-Ferrand, Clermont Ferrand, France.
authors.forename: Audrey
authors.initials: A
authors.lastname: Mirand
authors.affiliation: Laboratoire de virologie, AP-HP, Hôpital Necker - Enfants malades, Paris, France.
authors.forename: Marianne
authors.initials: M
authors.lastname: Leruez-Ville
authors.affiliation: Cellule d'intervention en région Ile de France, Santé publique France, Paris, France.
authors.forename: Clément
authors.initials: C
authors.lastname: Bassi
authors.affiliation: Service de neuropédiatrie, AP-HP, Hôpital Necker - Enfants malades, Paris, France.
authors.forename: Mélodie
authors.initials: M
authors.lastname: Aubart
authors.affiliation: Service de réanimation pédiatrique, AP-HP, Hôpital Necker - Enfants malades, Paris, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Moulin
authors.affiliation: Direction des maladies infectieuses, Santé publique France, Saint-Maurice, France.
authors.forename: Daniel
authors.initials: D
authors.lastname: Lévy-Bruhl
authors.affiliation: CNR des entérovirus et parechovirus-laboratoire associé, laboratoire de virologie, CHU de Clermont-Ferrand, Clermont Ferrand, France.
authors.forename: Cécile
authors.initials: C
authors.lastname: Henquell
authors.affiliation: CNR des entérovirus et parechovirus, laboratoire de virologie, Hospices civils de Lyon, Lyon, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Lina
authors.affiliation: Service de neuropédiatrie, AP-HP, Hôpital Necker - Enfants malades, Paris, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Desguerre
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D060085:Coinfection / Q000453:epidemiology / Q000821:virology*; D029821:Enterovirus A, Human / Q000235:genetics / Q000302:isolation & purification*; D030016:Enterovirus D, Human / Q000235:genetics / Q000302:isolation & purification*; D004769:Enterovirus Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000821:virology; D005260:Female; D005602:France / Q000453:epidemiology; D005838:Genotype; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D007223:Infant; D008297:Male; D058889:Molecular Typing; D009422:Nervous System Diseases / Q000150:complications / Q000821:virology*; D010802:Phylogeny; D012141:Respiratory Tract Infections / Q000175:diagnosis* / Q000453:epidemiology / Q000821:virology; D018571:Sentinel Surveillance; D017422:Sequence Analysis, DNA; D012720:Severity of Illness Index
keywords: Enterovirus A71; Enterovirus D68; France; children; severe neurological symptoms