title: Biological marks of early-life socioeconomic experience is detected in the adult inflammatory transcriptome.
abstract: Consistent evidence is accumulating to link lower socioeconomic position (SEP) and poorer health, and the inflammatory system stands out as a potential pathway through which socioeconomic environment is biologically embedded. Using bloodderived genome-wide transcriptional profiles from 268 Italian participants of the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, we evaluated the association between early life, young and later adulthood SEP and the expression of 845 genes involved in human inflammatory responses. These were examined individually and jointly using several inflammatory scores. Our results consistently show that participants whose father had a manual (as compared to nonmanual) occupation exhibit, later in life, a higher inflammatory score, hence indicating an overall increased level of expression for the selected inflammatory-related genes. Adopting a life course approach, these associations remained statistically significant upon adjustment for later-in-life socioeconomic experiences. Sensitivity analyses indicated that our findings were not affected by the way the inflammatory score was calculated, and were replicated in an independent study. Our study provides additional evidence that childhood SEP is associated with a sustainable upregulation of the inflammatory transcriptome, independently of subsequent socioeconomic experiences. Our results support the hypothesis that early social inequalities impacts adult physiology.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, W2 1PG London, UK.|INSERM, UMR1027, Toulouse F-31000, France.|Université Toulouse III Paul-Sabatier, UMR1027, Toulouse F-31000, France.
authors.forename: Raphaële
authors.initials: R
authors.lastname: Castagné
authors.affiliation: INSERM, UMR1027, Toulouse F-31000, France.|Université Toulouse III Paul-Sabatier, UMR1027, Toulouse F-31000, France.
authors.forename: Michelle
authors.initials: M
authors.lastname: Kelly-Irving
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, W2 1PG London, UK.
authors.forename: Gianluca
authors.initials: G
authors.lastname: Campanella
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, W2 1PG London, UK.
authors.forename: Florence
authors.initials: F
authors.lastname: Guida
authors.affiliation: Epidemiology and Prevention Unit, Fondazione IRCCS- Istituto Nazionale dei Tumori, Via Venezian 1, 20133 Milan, Italy.
authors.forename: Vittorio
authors.initials: V
authors.lastname: Krogh
authors.affiliation: Molecular and Nutritional Epidemiology Unit, Istituto per lo Studio e la Prevenzione Oncologica (ISPO Toscana), Via delle Oblate 2, 50141, Florence, Italy.
authors.forename: Domenico
authors.initials: D
authors.lastname: Palli
authors.affiliation: Department of Clinical Medicine and Surgery, University of Naples Federico II, Via Pansini 5, 80131 Naples, Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Panico
authors.affiliation: Piedmont Reference Centre for Epidemiology and Cancer Prevention (CPO Piemonte), Viale Settimio Severo nr. 65, 10133 Turin, Italy.
authors.forename: Carlotta
authors.initials: C
authors.lastname: Sacerdote
authors.affiliation: Cancer registry and Histopathology Unit, Azienda Ospedaliera 'Civile -M.P.Arezzo', Via Dante N 109, 97100 Ragusa, Italy.
authors.forename: Rosario
authors.initials: R
authors.lastname: Tumino
authors.affiliation: Department of Toxicogenomics, Maastricht University, 6211 LK Maastricht, The Netherlands.
authors.forename: Jos
authors.initials: J
authors.lastname: Kleinjans
authors.affiliation: Department of Toxicogenomics, Maastricht University, 6211 LK Maastricht, The Netherlands.
authors.forename: Theo
authors.initials: T
authors.lastname: de Kok
authors.affiliation: National Hellenic Research Foundation, Institute of Biology, Pharmaceutical Chemistry and Biotechnology, Vas. Constantinou 48, 11635 Athens, Greece.
authors.forename: Soterios A
authors.initials: SA
authors.lastname: Kyrtopoulos
authors.affiliation: INSERM, UMR1027, Toulouse F-31000, France.|Université Toulouse III Paul-Sabatier, UMR1027, Toulouse F-31000, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: Lang
authors.affiliation: Institute of Social and Preventive Medicine, Lausanne University Hospital, Route de la Corniche 10, 1010 Lausanne, Switzerland.
authors.forename: Silvia
authors.initials: S
authors.lastname: Stringhini
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, W2 1PG London, UK.|Institute for Risk Assessment Sciences (IRAS), Utrecht University, PO Box 80178, 3508 TD, Utrecht, The Netherlands.
authors.forename: Roel
authors.initials: R
authors.lastname: Vermeulen
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, W2 1PG London, UK.|HuGeF, Human Genetics Foundation, Via Nizza 52, 10126 Torino, Italy.|MRC-PHE Centre for Environment and Health, Imperial College, Praed Street Wing, St Mary's Campus, W2 1PG London, UK.
authors.forename: Paolo
authors.initials: P
authors.lastname: Vineis
authors.affiliation: INSERM, UMR1027, Toulouse F-31000, France.|Université Toulouse III Paul-Sabatier, UMR1027, Toulouse F-31000, France.
authors.forename: Cyrille
authors.initials: C
authors.lastname: Delpierre
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, W2 1PG London, UK.|MRC-PHE Centre for Environment and Health, Imperial College, Praed Street Wing, St Mary's Campus, W2 1PG London, UK.
authors.forename: Marc
authors.initials: M
authors.lastname: Chadeau-Hyam
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D005260:Female; D020869:Gene Expression Profiling; D055106:Genome-Wide Association Study; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012959:Socioeconomic Factors; D059467:Transcriptome
chemical_list: D015415:Biomarkers