title: A rare case of metastasized non-functional pancreatic neuroendocrine tumor with a good long-term survival.
abstract: Background:Non-functional neuroendocrine tumors of the pancreas (NF-pNETs) are a varied group of extremely rare malignancies. The majority of patients already have liver metastases at the diagnosis moment, thus, treatment options are restricted, and the survival rate is reserved.Case report:We presented the case of 59-year-old patient, diagnosed with non-functional well-differentiated pancreatic neuroendocrine tumor grade II (NET G2) with the presence of chromogranin A, synaptophysin and somatostatin receptor 2, together with liver and bone metastases. Patient underwent a surgical excision of the pancreatic tumor, started long-acting somatostatin analogues (octreotide), interferon therapy for liver metastases and local radiotherapy for bone metastases. After one year, the patient developed diabetes, needing insulin therapy. At approximately three years after the diagnosis, the patient was still living, had a good quality of life, and was free of local recurrence of the tumor or other metastases.Conclusion:Our case report presented a rare case of metastatic non-functional well-differentiated pancreatic neuroendocrine tumor, involving a multidisciplinary therapeutic approach in order to obtain a good long-term survival.
authors.affiliation: "C. I. Parhon" National Institute of Endocrinology, Bucharest, Romania ; Department of Physiology I, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
authors.forename: A
authors.initials: A
authors.lastname: Mirică
authors.affiliation: Department of Physiology I, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
authors.forename: I A
authors.initials: IA
authors.lastname: Bădărău
authors.affiliation: "Sf. Ioan" Emergency Hospital, Bucharest, Romania.
authors.forename: R
authors.initials: R
authors.lastname: Mirică
authors.affiliation: "Floreasca" Clinical Emergency Hospital, Bucharest, Romania.
authors.forename: S
authors.initials: S
authors.lastname: Păun
authors.affiliation: "C. I. Parhon" National Institute of Endocrinology, Bucharest, Romania.
authors.forename: D L
authors.initials: DL
authors.lastname: Păun
mesh_terms: D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use; D008875:Middle Aged; D015282:Octreotide / Q000627:therapeutic use; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000556:secondary* / Q000628:therapy; D011788:Quality of Life; D011994:Recombinant Proteins / Q000627:therapeutic use; D016019:Survival Analysis; D013997:Time Factors; D014057:Tomography, X-Ray Computed
chemical_list: D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D015282:Octreotide
keywords: pancreatic non-functional well-differentiated neuroendocrine tumor; survival rate; type 2 diabetes