title: Cardioprotective effects of curcumin-loaded magnetic hydrogel nanocomposite (nanocurcumin) against doxorubicin-induced cardiac toxicity in rat cardiomyocyte cell lines.
abstract: Curcumin, is a yellow substance extracted from Curcuma longa rhizomes, it is a crystalline compound that has been traditionally applied in culinary practices and medicines in India. The aim of our study is to demonstrate the efficacy of curcumin-loaded magnetic hydrogel nanocomposite in the treatment of heart hypertrophy. 10 rats weighing 150-200 g each were induced with heart failure using 2.5 mg/kg doxorubicin for 2 weeks. The test groups were treated with curcumin-loaded magnetic hydrogel nanocomposite while the control was treated with curcumin alone. malondialdehyde (MDA) levels, superoxide dismutase (SOD), and glutathione peroxidase (GPX) enzymes activities were monitored after two weeks of last the dose. In addition, the expression of three heart failure markers; atrial natriuretic peptide (ANP), B type natriuretic peptide (BNP), and beta major histocompatibility complex (β-MHC) were observed, it was found that the expression of these markers decreases with an increase in the concentration of curcumin (P < 0.05). Curcumin elevated the decreased level of GPX and SOD, and reduced the elevated level of MDA in cardiac tissue. We suggest this combination to be a potent therapy for heart failure and hypertension in the nearest future.
authors.affiliation: a Department of Cardiology , Lorestan University of Medical Sciences , Khoramabad , Iran.
authors.forename: Mehrdad
authors.initials: M
authors.lastname: Namdari
authors.affiliation: b Department of Medical Biotechnology, School of Advanced Technologies in Medicine , Tehran University of Medical sciences , Tehran , Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Eatemadi
mesh_terms: D000818:Animals; D009320:Atrial Natriuretic Factor / Q000235:genetics; D015415:Biomarkers / Q000378:metabolism; D002316:Cardiotonic Agents / Q000737:chemistry / Q000494:pharmacology; D002374:Catalase / Q000378:metabolism; D002460:Cell Line; D003474:Curcumin / Q000737:chemistry* / Q000494:pharmacology*; D004317:Doxorubicin / Q000633:toxicity*; D005786:Gene Expression Regulation / Q000187:drug effects; D006649:Histocompatibility Antigens / Q000235:genetics; D020100:Hydrogels / Q000737:chemistry*; D059346:Magnets / Q000737:chemistry*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D032383:Myocytes, Cardiac / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D053761:Nanocomposites; D020097:Natriuretic Peptide, Brain / Q000235:genetics; D018384:Oxidative Stress / Q000187:drug effects; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D015415:Biomarkers; D002316:Cardiotonic Agents; D006649:Histocompatibility Antigens; D020100:Hydrogels; D012333:RNA, Messenger; D020097:Natriuretic Peptide, Brain; D008315:Malondialdehyde; D004317:Doxorubicin; D009320:Atrial Natriuretic Factor; D002374:Catalase; D013482:Superoxide Dismutase; D003474:Curcumin
keywords: Cardioprotective; cardiac; curcumin; doxorubicin; toxicity