title: Enhanced Depth Imaging of Central Laminar Thickness in Optic Neuropathy: Comparison with Normal Eyes.
abstract: The purpose of this study was to compare central laminar thickness (LT) among patients with glaucomatous optic neuropathy (GON), patients with non-GON, and normal subjects using enhanced-depth imaging optical coherence tomography (EDI-OCT). Enrolled were 57 patients (n= 64 eyes), including 30 women and 27 men. Three groups were identified: GON (n= 18 eyes), non-GON (n= 16 eyes), and control (n= 30 eyes). The GON group comprised eyes with primary open-angle glaucoma (POAG) (n= 9) and normal-tension glaucoma (NTG) (n= 9). The non-GON group comprised eyes with demyelinating optic neuritis (n= 9), anterior ischemic optic neuropathy (AION) (n= 2), compressive ON (n= 2), Leber hereditary ON (n= 2), and traumatic ON (n= 1). GON and non-GON groups were further divided into mild, moderate, and severe subgroups. Inclusion in the GON group was based on mean deviations (MDs) of visual fields; inclusion in the non-GON group was based on critical flicker frequency (CFF) responses. Intraclass correlation coefficients (ICCs) were used to verify reproducibility of measurements. LTs of GON and non-GON group eyes were thinner than those of control group eyes (p< 0.01); LTs of GON group eyes were thinner than those of non-GON group eyes (p= 0.01). LTs of severe GON subgroup eyes were thinner than those of moderate and mild GON subgroup eyes (p< 0.001;p= 0.024, respectively). LTs of severe non-GON subgroup eyes were thinner than those of mild non-GON subgroup eyes (p= 0.002). These results show that EDI-OCT is valuable for documenting structural abnormalities in optic neuropathy (ON).
authors.affiliation: Department of Ophthalmology, Kitasato University School of Medicine , Kanagawa, Japan.
authors.forename: Suntaree
authors.initials: S
authors.lastname: Thitiwichienlert
authors.affiliation: Department of Ophthalmology, Kitasato University School of Medicine , Kanagawa, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ishikawa
authors.affiliation: Department of Ophthalmology, Kitasato University School of Medicine , Kanagawa, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Asakawa
authors.affiliation: Department of Ophthalmology, Kitasato University School of Medicine , Kanagawa, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Ikeda
authors.affiliation: Department of Ophthalmology, Kitasato University School of Medicine , Kanagawa, Japan.
authors.forename: Kimiya
authors.initials: K
authors.lastname: Shimizu
keywords: Enhanced depth imaging optical coherence tomography; glaucomatous optic neuropathy; lamina cribrosa; non-glaucomatous optic neuropathy