title: Acral manifestations of systemic diseases: Drug-induced and infectious diseases.
abstract: Drug reactions and systemic diseases often involve the skin. In particular, most drug-induced reactions and many infectious diseases present with dermatologic manifestations localized acrally, that is on distal portions of limbs (hand, foot) and head (ears, nose). A detailed review of all acral dermatologic signs of drug reactions and systemic diseases is beyond the scope of this paper, although some of these disorders will be discussed specifically here.
authors.affiliation: Department of Dermatology, Second University of Naples, Naples, Italy. Electronic address: stefano85med@libero.it.
authors.forename: Stefano
authors.initials: S
authors.lastname: Caccavale
authors.affiliation: Department of Dermatology, Second University of Naples, Naples, Italy.
authors.forename: Eleonora
authors.initials: E
authors.lastname: Ruocco
mesh_terms: D000169:Acrodermatitis / Q000175:diagnosis / Q000382:microbiology*; D061605:Administration, Intravenous; D000970:Antineoplastic Agents / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology* / Q000517:prevention & control; D004892:Erythema Multiforme / Q000139:chemically induced / Q000150:complications; D005533:Foot Dermatoses / Q000209:etiology*; D006229:Hand Dermatoses / Q000209:etiology*; D006232:Hand, Foot and Mouth Disease / Q000150:complications*; D006801:Humans; D010672:Phenytoin / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D000970:Antineoplastic Agents; D010672:Phenytoin