title: [. Oсumethyl in the treatment of allergic diseases of eyelids and conjunctiva].
abstract: Treatment of allergic diseases of eyelids and conjunctiva (conjunctivites and blepharoconjunctivites) often presents difficulties due to peculiarities of their pathogenesis - allergic and vascular reactions, disorder of lacrimal production, meibomian gland dysfunction, and possible bacterial contamination. It has been suggested to use Ocumethyl, which contains zinc sulfate (binding, drying, anti-inflammatory, and antiseptic effect), diphenhydamine hydrochloride (an Н1-antihistamine that decreases capillary permeability and helps resolve conjunctival and eyelid edema), naphazoline hydrochloride (a sympathomimetic notable for its strong, rapid, and long-lasting vasoconstrictive effect), and methylene blue (antiseptic effect, disintoxication, and antioxidant activity). A total of 80 patients with chronic allergic conjunctivitis, blepharoconjuntivitis, or giant papillary conjunctivitis associated with contact lens wearing were treated with Ocumethyl instillations (3 times daily for 15-30 days). A clinically significant effect was obtained in 77-91% of patients depending on the disease entity.
authors.affiliation: Research Institute of Eye Diseases, 11 A,B, Rossolimo St., 119021 Moscow, Russian Federation.
authors.forename: N R
authors.initials: NR
authors.lastname: Marchenko
mesh_terms: D018926:Anti-Allergic Agents / Q000008:administration & dosage / Q000009:adverse effects; D003233:Conjunctivitis, Allergic / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D004155:Diphenhydramine / Q000008:administration & dosage* / Q000009:adverse effects; D004338:Drug Combinations; D005141:Eyelid Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000150:complications*; D007322:Instillation, Drug; D008297:Male; D008751:Methylene Blue / Q000008:administration & dosage* / Q000009:adverse effects; D008875:Middle Aged; D009278:Naphazoline / Q000008:administration & dosage* / Q000009:adverse effects; D009883:Ophthalmic Solutions; D016896:Treatment Outcome; D019287:Zinc Sulfate / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D018926:Anti-Allergic Agents; D004338:Drug Combinations; D009883:Ophthalmic Solutions; D019287:Zinc Sulfate; D004155:Diphenhydramine; D009278:Naphazoline; D008751:Methylene Blue