title: Decoding the Ecological Function of Accessory Genome.
abstract: Shiga toxin-producing Escherichia coli O157:H7 primarily resides in cattle asymptomatically, and can be transmitted to humans through food. A study by Lupolova et al. applied a machine-learning approach to complex pan-genome information and predicted that only a small subset of bovine isolates have the potential to cause diseases in humans.
authors.affiliation: US Department of Agriculture, Agricultural Research Service, Western Regional Research Center, Produce Safety and Microbiology Research Unit, Albany, CA, USA. Electronic address: michelle.carter@ars.usda.gov.
authors.forename: Michelle Qiu
authors.initials: MQ
authors.lastname: Carter
mesh_terms: D000818:Animals; D002417:Cattle; D004927:Escherichia coli Infections / Q000382:microbiology / Q000635:transmission*; D019453:Escherichia coli O157 / Q000235:genetics* / Q000302:isolation & purification / Q000378:metabolism / Q000472:pathogenicity*; D029968:Escherichia coli Proteins / Q000235:genetics*; D005516:Food Microbiology; D016680:Genome, Bacterial / Q000235:genetics; D044404:Genomic Islands / Q000235:genetics; D006801:Humans; D010750:Phosphoproteins / Q000235:genetics*; D022621:Shiga Toxin / Q000378:metabolism*; D037521:Virulence Factors / Q000235:genetics
chemical_list: D029968:Escherichia coli Proteins; C457340:LEE protein, E coli; D010750:Phosphoproteins; D037521:Virulence Factors; D022621:Shiga Toxin
keywords: Shiga toxin-producing Escherichia coli; accessory genome; enterohemorrhagic Escherichia coli; pan-genome; support vector machine; zoonotic potential