title: Regulation of downstream neuronal genes by proneural transcription factors during initial neurogenesis in the vertebrate brain.
abstract: Neurons arise in very specific regions of the neural tube, controlled by components of the Notch signalling pathway, proneural genes, and other bHLH transcription factors. How these specific neuronal areas in the brain are generated during development is just beginning to be elucidated. Notably, the critical role of proneural genes during differentiation of the neuronal populations that give rise to the early axon scaffold in the developing brain is not understood. The regulation of their downstream effectors remains poorly defined.
  
  
  
  This study provides the first overview of the spatiotemporal expression of proneural genes in the neuronal populations of the early axon scaffold in both chick and mouse. Overexpression studies and mutant mice have identified a number of specific neuronal genes that are targets of proneural transcription factors in these neuronal populations.
  
  
  
  Together, these results improve our understanding of the molecular mechanisms involved in differentiation of the first neuronal populations in the brain.
authors.affiliation: Institut de Génétique et Développement de Rennes, Faculté de Médecine, CNRS UMR6290, Université de Rennes 1, IFR140 GFAS, 2 Avenue du Pr. Léon Bernard, 35043, Rennes Cedex, France.|Present address: Department of Physiology, Development and Neuroscience, University of Cambridge, Anatomy Building, Downing Street, CB2 3DY, Cambridge, UK.
authors.forename: Michelle
authors.initials: M
authors.lastname: Ware
authors.affiliation: Institut de Génétique et Développement de Rennes, Faculté de Médecine, CNRS UMR6290, Université de Rennes 1, IFR140 GFAS, 2 Avenue du Pr. Léon Bernard, 35043, Rennes Cedex, France.|Laboratoire de Génétique Moléculaire, CHU Pontchaillou, Rennes Cedex, France.
authors.forename: Houda
authors.initials: H
authors.lastname: Hamdi-Rozé
authors.affiliation: Institut de Génétique et Développement de Rennes, Faculté de Médecine, CNRS UMR6290, Université de Rennes 1, IFR140 GFAS, 2 Avenue du Pr. Léon Bernard, 35043, Rennes Cedex, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Le Friec
authors.affiliation: Institut de Génétique et Développement de Rennes, Faculté de Médecine, CNRS UMR6290, Université de Rennes 1, IFR140 GFAS, 2 Avenue du Pr. Léon Bernard, 35043, Rennes Cedex, France.|Laboratoire de Génétique Moléculaire, CHU Pontchaillou, Rennes Cedex, France.
authors.forename: Véronique
authors.initials: V
authors.lastname: David
authors.affiliation: Institut de Génétique et Développement de Rennes, Faculté de Médecine, CNRS UMR6290, Université de Rennes 1, IFR140 GFAS, 2 Avenue du Pr. Léon Bernard, 35043, Rennes Cedex, France. valerie.dupe@univ-rennes1.fr.
authors.forename: Valérie
authors.initials: V
authors.lastname: Dupé
mesh_terms: D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics*; D001921:Brain / Q000196:embryology* / Q000378:metabolism*; D002454:Cell Differentiation; D002645:Chickens; D018507:Gene Expression Regulation, Developmental; D051379:Mice; D018345:Mice, Knockout; D009419:Nerve Tissue Proteins / Q000235:genetics; D055495:Neurogenesis; D051880:Receptors, Notch / Q000235:genetics; D015398:Signal Transduction; D013045:Species Specificity
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D009419:Nerve Tissue Proteins; D051880:Receptors, Notch; C499317:Ascl1 protein, mouse; C102938:Neurog2 protein, mouse; C486336:Neurog1 protein, mouse
keywords: Ascl1; Chga; Early axon scaffold; Embryonic; Neurogenin; Notch; Rbpj; Tagln3