title: A simple method for preparation of pure68Ga-acetate precursor for formulation of radiopharmaceuticals: Physicochemical characteristics of the68Ga eluate of the SnO2based-68Ge/68Ga column generator.
abstract: Gallium-68 radioisotope is an excellent source in clinical positron emission tomography application due to its ease of availability from germanium-68 (68Ge)/gallium-68 (68Ga) generator having a shelf life of 1 year. In this paper, a modified method for purification of the primary eluate of68Ge-68Ga generator by using a small cation exchange resin (Dowex-50) column has been described. The breakthrough of68Ge before and after purification of68Ga eluate was 0.014% and 0.00027%, respectively. The average recovery yield of68Ga after purification was 84% ± 8.6% (SD, n = 335). The results of the physiochemical studies confirmed that the68Ga-acetate obtained is suitable for labeling of radiopharmaceuticals.
authors.affiliation: Radiopharmaceuticals Lab, Regional Centre, Board of Radiation and Isotope Technology (BRIT), Variable Energy Cyclotron Centre (VECC), Bidhan Nagar, Kolkata, India.
authors.forename: Sankha
authors.initials: S
authors.lastname: Chattopadhyay
authors.affiliation: Radiopharmaceuticals Lab, Regional Centre, Board of Radiation and Isotope Technology (BRIT), Variable Energy Cyclotron Centre (VECC), Bidhan Nagar, Kolkata, India.
authors.forename: Md Neyar
authors.initials: MN
authors.lastname: Alam
authors.affiliation: Radiopharmaceuticals Lab, Regional Centre, Board of Radiation and Isotope Technology (BRIT), Variable Energy Cyclotron Centre (VECC), Bidhan Nagar, Kolkata, India.
authors.forename: Madhu
authors.initials: M
authors.lastname: Smita
authors.affiliation: Radiopharmaceuticals Lab, Regional Centre, Board of Radiation and Isotope Technology (BRIT), Variable Energy Cyclotron Centre (VECC), Bidhan Nagar, Kolkata, India.
authors.forename: Umesh
authors.initials: U
authors.lastname: Kumar
authors.affiliation: Radiopharmaceuticals Lab, Regional Centre, Board of Radiation and Isotope Technology (BRIT), Variable Energy Cyclotron Centre (VECC), Bidhan Nagar, Kolkata, India.
authors.forename: Sujata Saha
authors.initials: SS
authors.lastname: Das
authors.affiliation: Radiopharmaceuticals Lab, Regional Centre, Board of Radiation and Isotope Technology (BRIT), Variable Energy Cyclotron Centre (VECC), Bidhan Nagar, Kolkata, India.
authors.forename: Luna
authors.initials: L
authors.lastname: Barua
mesh_terms: D000085:Acetates / Q000737:chemistry; D060326:Chemistry Techniques, Synthetic / Q000295:instrumentation / Q000379:methods; D005710:Gallium Radioisotopes / Q000737:chemistry*; D011876:Radionuclide Generators / Q000295:instrumentation*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000737:chemistry; D017971:Tin Compounds / Q000737:chemistry*
chemical_list: D000085:Acetates; D005710:Gallium Radioisotopes; D019275:Radiopharmaceuticals; D017971:Tin Compounds; C045358:stannic oxide
keywords: 68Ga-acetate; 68Ge-68Ga generator; Dowex-50 resin; Post purification; SnO2 column