title: A scavenger peptide prevents methylglyoxal induced pain in mice.
abstract: The reactive metabolite methylglyoxal (MG) has been identified as mediator of pain. Scavenging of free MG and the prevention of MG-derived post-translational modifications may provide a useful therapeutic treatment. An arginine-rich, fatty acid coupled, cyclic peptide (CycK(Myr)R4E) with high proteolytic stability and prolonged circulation was developed for the scavenging of MG. It was shown to reduce the formation of albumin-MG adducts in vitro and prevented MG-induced pain by reducing plasma MG levels through the formation of peptide-MG adducts in vivo. CycK(Myr)R4E therefore presents a promising option for the treatment of pain and other diabetic complications associated with high MG levels.
authors.affiliation: Department of Medicine I and Clinical Chemistry, University Hospital Heidelberg, Heidelberg, Germany; Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany. Electronic address: sebastian.brings@med.uni-heidelberg.de.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Brings
authors.affiliation: Department of Medicine I and Clinical Chemistry, University Hospital Heidelberg, Heidelberg, Germany; German Center for Diabetes Research (DZD), München-Neuherberg, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Fleming
authors.affiliation: Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany.
authors.forename: Svenja
authors.initials: S
authors.lastname: De Buhr
authors.affiliation: Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany.
authors.forename: Barbro
authors.initials: B
authors.lastname: Beijer
authors.affiliation: Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Lindner
authors.affiliation: Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany.
authors.forename: Artjom
authors.initials: A
authors.lastname: Wischnjow
authors.affiliation: Department of Medicine II, Semmelweis University, Budapest, Hungary.
authors.forename: Zoltan
authors.initials: Z
authors.lastname: Kender
authors.affiliation: Centre for Pediatrics and Adolescence Medicine, University Hospital Heidelberg, Heidelberg, Germany.
authors.forename: Verena
authors.initials: V
authors.lastname: Peters
authors.affiliation: Department of Medicine I and Clinical Chemistry, University Hospital Heidelberg, Heidelberg, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Kopf
authors.affiliation: Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany.
authors.forename: Uwe
authors.initials: U
authors.lastname: Haberkorn
authors.affiliation: Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany.
authors.forename: Walter
authors.initials: W
authors.lastname: Mier
authors.affiliation: Department of Medicine I and Clinical Chemistry, University Hospital Heidelberg, Heidelberg, Germany; German Center for Diabetes Research (DZD), München-Neuherberg, Germany; Joint Heidelberg-IDC Translational Diabetes Program, Helmholtz-Zentrum, München-Neuherberg, Germany.
authors.forename: Peter P
authors.initials: PP
authors.lastname: Nawroth
mesh_terms: D000595:Amino Acid Sequence; D000700:Analgesics / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000818:Animals; D051379:Mice; D008810:Mice, Inbred C57BL; D010146:Pain / Q000097:blood / Q000378:metabolism / Q000517:prevention & control*; D010456:Peptides, Cyclic / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use*; D011765:Pyruvaldehyde / Q000097:blood / Q000378:metabolism*; D012709:Serum Albumin / Q000378:metabolism
chemical_list: D000700:Analgesics; D010456:Peptides, Cyclic; D012709:Serum Albumin; D011765:Pyruvaldehyde
keywords: Diabetic complications; Methylglyoxal; Pain; Peptide; Scavenger