title: Elements of biological oscillations in time and space.
abstract: Oscillations in time and space are ubiquitous in nature and play critical roles in dynamic cellular processes. Although the molecular mechanisms underlying the generation of the dynamics are diverse, several distinct regulatory elements have been recognized as being critical in producing and modulating oscillatory dynamics. These include negative and positive feedback, time delay, nonlinearity in regulation, and random fluctuations ('noise'). Here we discuss the specific roles of these five elements in promoting or attenuating oscillatory dynamics, by drawing on insights from quantitative analyses of natural or synthetic biological networks.
authors.affiliation: Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA.
authors.forename: Yangxiaolu
authors.initials: Y
authors.lastname: Cao
authors.affiliation: Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA.
authors.forename: Allison
authors.initials: A
authors.lastname: Lopatkin
authors.affiliation: Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA.|Center for Genomic and Computational Biology, Duke University, Durham, North Carolina, USA.|Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA.
authors.forename: Lingchong
authors.initials: L
authors.lastname: You
mesh_terms: D000818:Animals; D001683:Biological Clocks; D003198:Computer Simulation; D025461:Feedback, Physiological; D006801:Humans; D008954:Models, Biological; D010507:Periodicity; D049490:Systems Biology