title: Calcitonin-negative primary neuroendocrine tumor of the thyroid (nonmedullary) in a dog.
abstract: The Calcitonin-negative neuroendocrine tumor of the thyroid (CNNET) or "nonmedullary" in humans is a rare tumor that arises primarily in the thyroid gland and may be mistaken for medullary thyroid carcinoma; it is characterized by the immunohistochemical (IHC) expression of neuroendocrine markers and the absence of expression for calcitonin. An Argentine dogo bitch showed a solid, compact thyroid tumor, which was IHC negative for the expression of calcitonin, carcinoembryonic antigen, thyroglobulin and S100 protein, and positive for synaptophysin and cytokeratin AE1-AE3. The Ki-67 proliferation index was low. We cite this case not only because it is the first case report of calcitonin-negative primary neuroendocrine tumor of the thyroid in dogs but also because we want to highlight the diagnostic importance of IHC in this regard.
authors.affiliation: Hospital Escuela, Unidad de Endocrinología, Area de Clínica Médica de Pequeños Animales, Fac. de Ciencias Veterinarias, UBA, Av. Chorroarín 280, Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: E A Soler
authors.initials: EA
authors.lastname: Arias
authors.affiliation: Hospital Escuela, Unidad de Endocrinología, Area de Clínica Médica de Pequeños Animales, Fac. de Ciencias Veterinarias, UBA, Av. Chorroarín 280, Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: V A
authors.initials: VA
authors.lastname: Castillo
authors.affiliation: Alumna de Programa de Investigación. Fac. de Ciencias Veterinarias, UBA, Chorroarín 280, Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: M E Caneda
authors.initials: ME
authors.lastname: Aristarain
keywords: Calcitonin-negative; Immunohistochemistry; Ki-67; Medullary thyroid carcinoma; Neuroendocrine