title: Roles of Erythroid Differentiation Regulator 1 (Erdr1) on Inflammatory Skin Diseases.
abstract: Erythroid Differentiation Regulator 1 (Erdr1) is known as a hemoglobin synthesis factor which also regulates cell survival under conditions of stress. In addition, previous studies have revealed the effects of Erdr1 on cancer progression and its negative correlation with interleukin (IL)-18, a pro-inflammatory cytokine. Based on this evidence, the therapeutic effects of Erdr1 have been demonstrated in several inflammatory skin diseases such as malignant skin cancer, psoriasis, and rosacea. This article reviews the roles of Erdr1 in skin inflammation, suggesting that Erdr1 is a potential therapeutic molecule on inflammatory disorders.
authors.affiliation: Department of Biological Sciences, Sookmyung Women's University, Seoul 04310, Korea. bobada6025@gmail.com.
authors.forename: Youn Kyung
authors.initials: YK
authors.lastname: Houh
authors.affiliation: Department of Cosmetic Sciences, Sookmyung Women's University, Seoul 04310, Korea. kyungeun@sookmyung.ac.kr.
authors.forename: Kyung Eun
authors.initials: KE
authors.lastname: Kim
authors.affiliation: Department of Dermatology, Yeouido St. Mary's Hospital, The Catholic University of Korea, Seoul 07345, Korea. hjpark@catholic.ac.kr.
authors.forename: Hyun Jeong
authors.initials: HJ
authors.lastname: Park
authors.affiliation: Department of Biological Sciences, Sookmyung Women's University, Seoul 04310, Korea. cdhkor@sookmyung.ac.kr.|Department of Cosmetic Sciences, Sookmyung Women's University, Seoul 04310, Korea. cdhkor@sookmyung.ac.kr.
authors.forename: Daeho
authors.initials: D
authors.lastname: Cho
mesh_terms: D006801:Humans; D007249:Inflammation / Q000378:metabolism* / Q000473:pathology; D008954:Models, Biological; D058990:Molecular Targeted Therapy; D012871:Skin Diseases / Q000378:metabolism* / Q000473:pathology; D025521:Tumor Suppressor Proteins / Q000378:metabolism*
chemical_list: D025521:Tumor Suppressor Proteins
keywords: Erdr1; IL-18; cutaneous inflammation; melanoma; psoriasis; rosacea