title: Total knee arthroplasty improves both knee function and disease activity in patients with rheumatoid arthritis.
abstract: OBJECTIVE
  This study evaluated the effect of TKA with capsulosynovectomy on disease activity and knee function in patients with RA.
  
  
  METHODS
  Seventy-six RA patients who underwent primary TKA with more than two years of follow-up were retrospectively reviewed to assess postoperative knee function and disease activity.
  
  
  RESULTS
  Postoperative knee function was significantly improved in all clinical scores, and maintained up to 24 months after surgery. RA disease activity was significantly decreased in DAS28-CRP, CDAI, and serum CRP level, and maintained up to 24 months after surgery. Postoperative knee function was negatively correlated with RA disease activity.
  
  
  CONCLUSIONS
  TKA improves both knee function and disease activity in patients with rheumatoid arthritis.
authors.affiliation: a Department of Orthopaedic Surgery , Yokohama City University , Yokohama , Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Kumagai
authors.affiliation: a Department of Orthopaedic Surgery , Yokohama City University , Yokohama , Japan.
authors.forename: Kengo
authors.initials: K
authors.lastname: Harigane
authors.affiliation: a Department of Orthopaedic Surgery , Yokohama City University , Yokohama , Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Kusayama
authors.affiliation: a Department of Orthopaedic Surgery , Yokohama City University , Yokohama , Japan.
authors.forename: Taro
authors.initials: T
authors.lastname: Tezuka
authors.affiliation: a Department of Orthopaedic Surgery , Yokohama City University , Yokohama , Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Inaba
authors.affiliation: a Department of Orthopaedic Surgery , Yokohama City University , Yokohama , Japan.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Saito
mesh_terms: D000368:Aged; D001172:Arthritis, Rheumatoid / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery; D019645:Arthroplasty, Replacement, Knee / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007719:Knee Joint / Q000503:physiopathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D062072:Patient Acuity; D020127:Recovery of Function; D012189:Retrospective Studies; D013223:Statistics as Topic; D000074402:Synovectomy / Q000379:methods*
keywords: Disease activity; Knee function; Rheumatoid arthritis; Total knee arthroplasty