title: 4D Printing of Shape Memory-Based Personalized Endoluminal Medical Devices.
abstract: The convergence of additive manufacturing and shape-morphing materials is promising for the advancement of personalized medical devices. The capability to transform 3D objects from one shape to another, right off the print bed, is known as 4D printing. Shape memory thermosets can be tailored to have a range of thermomechanical properties favorable to medical devices, but processing them is a challenge because they are insoluble and do not flow at any temperature. This study presents here a strategy to capitalize on a series of medical imaging modalities to construct a printable shape memory endoluminal device, exemplified by a tracheal stent. A methacrylated polycaprolactone precursor with a molecular weight of 10 000 g mol-1is printed with a UV-LED stereolithography printer based on anatomical data. This approach converges with the zeitgeist of personalized medicine and it is anticipated that it will broadly expand the application of shape memory-exhibiting biomedical devices to myriad clinical indications.
authors.affiliation: Casali Center of Applied Chemistry, Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel.
authors.forename: Matt
authors.initials: M
authors.lastname: Zarek
authors.affiliation: Casali Center of Applied Chemistry, Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel.
authors.forename: Nicola
authors.initials: N
authors.lastname: Mansour
authors.affiliation: Ulpanat Bnei Akiva Orot Modi'in, 21 Nakhal Tsalmon St, Modi'in, 71749, Israel.
authors.forename: Shir
authors.initials: S
authors.lastname: Shapira
authors.affiliation: Casali Center of Applied Chemistry, Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel.
authors.forename: Daniel
authors.initials: D
authors.lastname: Cohn
mesh_terms: D004864:Equipment and Supplies; D011091:Polyesters / Q000138:chemical synthesis / Q000737:chemistry*; D057285:Precision Medicine; D011327:Printing; D013696:Temperature
chemical_list: D011091:Polyesters; C016240:polycaprolactone
keywords: 4D printing; biomedical devices; personalized medicine; shape-memory polymers