title: Prognostic Implications of Newly Developed T-Wave Inversion After Primary Percutaneous Coronary Intervention in Patients With ST-Segment Elevation Myocardial Infarction.
abstract: We investigated the prognostic value of newly developed T-wave inversion after primary percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction. New T-wave inversion was defined as new onset of T-wave inversion after the primary PCI, without negative T waves on the presenting electrocardiogram. The primary end point was the occurrence of major adverse cardiac events (MACE), which consisted of cardiovascular mortality, nonfatal myocardial infarction, and rehospitalization for heart failure. A total of 271 patients were analyzed and followed up for 24 months in this study. New T-wave inversion was observed in 194 patients (72%), whereas the remaining 77 patients (28%) did not show T-wave inversion after the index PCI. Post-PCI Thrombolysis In Myocardial Infarction flow grade 2 or 3 was observed more frequently in patients with new T-wave inversion (97% vs 90%; p = 0.011). The cumulative MACE rate was significantly lower in patients with new T-wave inversion than in those without new T-wave inversion (8% vs 30%; odds ratio 0.197, 95% confidential interval 0.096 to 0.403; p <0.001). In multivariate Cox regression analysis, new T-wave inversion was an independent prognostic factor for MACE (hazard ratio 0.297, 95% confidential interval 0.144 to 0.611; p = 0.001). In conclusion, newly developed T-wave inversion after primary PCI was associated with favorable long-term outcome.
authors.affiliation: Department of Cardiology, Inha University Hospital, Incheon, Republic of Korea.
authors.forename: Man-Jong
authors.initials: MJ
authors.lastname: Lee
authors.affiliation: Department of Cardiology, Inha University Hospital, Incheon, Republic of Korea.
authors.forename: Ji-Hoon
authors.initials: JH
authors.lastname: Jang
authors.affiliation: Department of Cardiology, Inha University Hospital, Incheon, Republic of Korea.
authors.forename: Myung-Dong
authors.initials: MD
authors.lastname: Lee
authors.affiliation: Department of Cardiology, Inha University Hospital, Incheon, Republic of Korea.
authors.forename: Sung Woo
authors.initials: SW
authors.lastname: Kwon
authors.affiliation: Department of Cardiology, Inha University Hospital, Incheon, Republic of Korea.
authors.forename: Sung-Hee
authors.initials: SH
authors.lastname: Shin
authors.affiliation: Department of Cardiology, Inha University Hospital, Incheon, Republic of Korea. Electronic address: denki1@inha.ac.kr.
authors.forename: Sang-Don
authors.initials: SD
authors.lastname: Park
authors.affiliation: Department of Cardiology, Inha University Hospital, Incheon, Republic of Korea.
authors.forename: Seong-Ill
authors.initials: SI
authors.lastname: Woo
authors.affiliation: Department of Cardiology, Inha University Hospital, Incheon, Republic of Korea.
authors.forename: Dae-Hyeok
authors.initials: DH
authors.lastname: Kim
authors.affiliation: Department of Cardiology, Inha University Hospital, Incheon, Republic of Korea.
authors.forename: Jun
authors.initials: J
authors.lastname: Kwan
authors.affiliation: Department of Cardiology, Inha University Hospital, Incheon, Republic of Korea.
authors.forename: Keum-Soo
authors.initials: KS
authors.lastname: Park
mesh_terms: D000368:Aged; D053840:Brugada Syndrome / Q000453:epidemiology*; D000075224:Cardiac Conduction System Disease; D002318:Cardiovascular Diseases / Q000401:mortality; D004562:Electrocardiography; D005260:Female; D006333:Heart Failure / Q000453:epidemiology; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000453:epidemiology; D016017:Odds Ratio; D062645:Percutaneous Coronary Intervention; D011183:Postoperative Complications / Q000453:epidemiology*; D011379:Prognosis; D016016:Proportional Hazards Models; D065840:Protective Factors; D012189:Retrospective Studies; D000072657:ST Elevation Myocardial Infarction / Q000601:surgery*