title: Non-adherence to antiretroviral therapy in patients infected with HIV and cryptococcal meningitis: two cases at the Lambaréné Hospital Center in Gabon.
abstract: Cryptococcal meningitis is a serious infection occurring mainly in immunodepressed patients, especially those with AIDS. Its incidence is growing among people living with HIV/AIDS who interrupt their antiretroviral treatment. We report two cases that occurred in this situation and had lethal outcomes in the short term. Testing for cryptococcal antigen in serum (serum CRAG test) enables a reliable and early diagnosis, and its use should be promoted in rural areas of sub-Saharan Africa.
authors.affiliation: Centre hospitalier universitaire de Libreville, Centre hospitalier regional de Lambaréné, Gabon. Université des sciences de la santé de Libreville, BP 2228 Libreville, Gabon.
authors.forename: U D
authors.initials: UD
authors.lastname: Kombila
authors.affiliation: Centre hospitalier universitaire de Libreville, Université des sciences de la santé de Libreville, Gabon.
authors.forename: J
authors.initials: J
authors.lastname: Iba Ba
authors.affiliation: Centre hospitalier de Lambaréné, Lambaréné, Gabon.
authors.forename: G
authors.initials: G
authors.lastname: Tsoumbou-Bakana
authors.affiliation: Centre hospitalier universitaire de Libreville, Université des sciences de la santé de Libreville, Libreville, Gabon.
authors.forename: J-B
authors.initials: JB
authors.lastname: Moussavou Kombila
mesh_terms: D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D017809:Fatal Outcome; D005260:Female; D005681:Gabon; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy*; D006761:Hospitals; D006801:Humans; D055118:Medication Adherence; D016919:Meningitis, Cryptococcal / Q000150:complications*; D008875:Middle Aged
chemical_list: D044966:Anti-Retroviral Agents
keywords: Gabon; meningeal cryptococcosis; serum CRAG test