title: Admission neutrophil count and neutrophil to lymphocyte ratio predict 90-day outcome in intracerebral hemorrhage.
abstract: OBJECTIVE
  Inflammation plays a role in secondary brain injury after intracerebral hemorrhage (ICH). We aimed to determine the prognostic significance of admission white blood cell (AWC), neutrophil count (ANC), lymphocyte count, monocyte count and neutrophil to lymphocyte ratio (NLR) for 90-day outcome after ICH.
  
  
  METHODS
  A total of 336 patients with spontaneous ICH were retrospectively investigated. Clinical outcome was assessed by modified Rankin Scale at 90 days.
  
  
  RESULTS
  Multivariate analysis showed that higher AWC, ANC, NLR were independently associated with mortality and worse outcome. Moreover, NLR showed a higher predictive ability in mortality than in poor outcome in receiver operating characteristic analysis. Linear regression analyses revealed admission Glasgow Coma Scale score and ICH volume were mostly correlated with these indices.
  
  
  CONCLUSIONS
  Elevated levels of AWC, ANC and NLR were independently related to poor 90-day outcome after ICH. NLR may be a novel inflammatory biomarker following ICH.
authors.affiliation: Stroke Clinical Research Unit, Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610041, PR China.
authors.forename: Chuanyuan
authors.initials: C
authors.lastname: Tao
authors.affiliation: Stroke Clinical Research Unit, Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610041, PR China.
authors.forename: Xin
authors.initials: X
authors.lastname: Hu
authors.affiliation: Department of Critical Care Medicine, Neurosurgical Intensive Care Unit, West China Hospital, Sichuan University, Chengdu 610041, PR China.
authors.forename: Jiajing
authors.initials: J
authors.lastname: Wang
authors.affiliation: Stroke Clinical Research Unit, Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610041, PR China.
authors.forename: Junpeng
authors.initials: J
authors.lastname: Ma
authors.affiliation: Stroke Clinical Research Unit, Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610041, PR China.
authors.forename: Hao
authors.initials: H
authors.lastname: Li
authors.affiliation: Stroke Clinical Research Unit, Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610041, PR China.
authors.forename: Chao
authors.initials: C
authors.lastname: You
mesh_terms: D000368:Aged; D019540:Area Under Curve; D002543:Cerebral Hemorrhage / Q000175:diagnosis / Q000401:mortality / Q000473:pathology*; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D007958:Leukocyte Count; D016014:Linear Models; D008214:Lymphocytes / Q000166:cytology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009504:Neutrophils / Q000166:cytology*; D016017:Odds Ratio; D011379:Prognosis; D012372:ROC Curve; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013997:Time Factors; D014057:Tomography, X-Ray Computed
keywords: inflammation; intracerebral hemorrhage; mortality; neutrophil to lymphocyte ratio; outcome; stroke