title: Association between IL-27 gene polymorphisms and risk of papillary thyroid carcinoma.
abstract: OBJECTIVE
  IL-27 has potent antitumor effects. We aimed to examine the contribution of single nucleotide polymorphisms in IL-27 to the risk of papillary thyroid carcinoma (PTC).
  
  
  METHODS
  IL-27 rs153109 and rs17855750 were analyzed in 496 PTC patients and 629 controls, using a polymerase chain reaction-restriction fragment length polymorphism method.
  
  
  RESULTS
  The rs153109 AG and AG/GG genotypes were significantly associated with increased risks for PTC. Significantly increased PTC risk was also associated with rs17855750 GT and GT/GG genotypes. Combined genotypes of rs153109 AG/GG and rs17855750 GT/GG increased the risk of PTC (p < 0.05).
  
  
  CONCLUSIONS
  These findings showed that IL-27 rs153109 and rs17855750 might be related to the tumorigenesis of PTC.
authors.affiliation: Department of Immunology, West China School of Preclinical & Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, PR China.
authors.forename: Xinwen
authors.initials: X
authors.lastname: Nie
authors.affiliation: Department of Immunology, West China School of Preclinical & Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, PR China.
authors.forename: Fang
authors.initials: F
authors.lastname: Yuan
authors.affiliation: Department of Forensic Biology, West China School of Preclinical & Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, PR China.
authors.forename: Peng
authors.initials: P
authors.lastname: Chen
authors.affiliation: Department of Forensic Biology, West China School of Preclinical & Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Pu
authors.affiliation: Department of Thyroid & Breast Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China.
authors.forename: Jingqiang
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Department of Thyroid & Breast Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China.
authors.forename: Yichao
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Obstetrics & Gynaecology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China.
authors.forename: Xue
authors.initials: X
authors.lastname: Xiao
authors.affiliation: Department of Immunology, West China School of Preclinical & Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, PR China.
authors.forename: Guanglu
authors.initials: G
authors.lastname: Che
authors.affiliation: Laboratory of Molecular & Translational Medicine, West China Institute of Women & Children's Health, Key Laboratory of Birth Defects & Related Diseases of Women & Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China.
authors.forename: Linbo
authors.initials: L
authors.lastname: Gao
authors.affiliation: Department of Immunology, West China School of Preclinical & Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, PR China.|Laboratory of Molecular & Translational Medicine, West China Institute of Women & Children's Health, Key Laboratory of Birth Defects & Related Diseases of Women & Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000483:Alleles; D002291:Carcinoma, Papillary / Q000175:diagnosis / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D064094:Interleukin-27 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000235:genetics*
chemical_list: D064094:Interleukin-27
keywords: IL-27; papillary thyroid carcinoma; risk; rs153109; rs17855750; single nucleotide polymorphism