title: Systematic approach to understanding the pathogenesis of systemic sclerosis.
abstract: Systemic sclerosis (SSc) is a complex heterogeneous autoimmune disease. Progressive organ fibrosis is a major contributor to SSc mortality. Despite extensive efforts, the underlying mechanism of SSc remains unclear. Efforts to understand the pathogenesis of SSc have included genomics, epigenetics, transcriptomic, proteomic and metabolomic studies in the last decade. This review focuses on recent studies in SSc research based on multi-omics. The combination of these technologies can help us understand the pathogenesis of SSc. This review aims to provide important information for disease identification, therapeutic targets and potential biomarkers.
authors.affiliation: Department of Rheumatology, Xiangya Hospital, Central South University, Changsha, People's Republic of China.
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Zuo
authors.affiliation: Department of Rheumatology, Xiangya Hospital, Central South University, Changsha, People's Republic of China.
authors.forename: Lihua
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Rheumatology, Xiangya Hospital, Central South University, Changsha, People's Republic of China.
authors.forename: Hui
authors.initials: H
authors.lastname: Luo
authors.affiliation: Department of Rheumatology, Xiangya Hospital, Central South University, Changsha, People's Republic of China.
authors.forename: Yisha
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Rheumatology, Xiangya Hospital, Central South University, Changsha, People's Republic of China.
authors.forename: Honglin
authors.identifier: http://orcid.org/0000-0002-9322-5684
authors.initials: H
authors.lastname: Zhu
mesh_terms: D015415:Biomarkers; D044127:Epigenesis, Genetic / Q000235:genetics; D006801:Humans; D035683:MicroRNAs / Q000235:genetics; D040901:Proteomics; D012595:Scleroderma, Systemic / Q000235:genetics* / Q000503:physiopathology; D059467:Transcriptome / Q000235:genetics*
chemical_list: D015415:Biomarkers; D035683:MicroRNAs
keywords: combination; multi-omics; pathogenesis; systemic sclerosis