title: Hyperglycemia as a possible risk factor for mold infections-the potential preventative role of intensified glucose control in allogeneic hematopoietic stem cell transplantation.
abstract: Diabetes mellitus (DM) is well-known as a disorder that increases the risk of infectious diseases. Various reports have shown that innate immunity is impaired in patients with DM, which is considered to be a major cause of increased risk of infectious diseases. However, there is a paucity of data about the actual risk of mold infections in patients with DM. Several treatment procedures, such as solid organ transplantation and hematopoietic stem cell transplantation (HSCT), are intrinsically associated with a high risk of mold infections and also correlated with an increased risk of post-transplant DM. Therefore, we could assume that organ transplant recipients or HSCT recipients with DM are at quite high risk of mold infections. Here, we aim to summarize the information about the increased risk of mold infections in patients with DM, and propose possible interventions such as intensive glucose control to reduce this risk in patients with DM.
authors.affiliation: Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan.|Department of Internal Medicine II, Division of Hematology/Oncology, University Hospital of Würzburg, Würzburg, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Fuji
authors.affiliation: Department of Internal Medicine II, Division of Hematology/Oncology, University Hospital of Würzburg, Würzburg, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Löffler
authors.affiliation: Hematology and Stem Cell Transplantation Section, Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center and Veterans Affairs Medical Center, Nashville, TN, USA.
authors.forename: B N
authors.initials: BN
authors.lastname: Savani
authors.affiliation: Department of Internal Medicine II, Division of Hematology/Oncology, University Hospital of Würzburg, Würzburg, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Einsele
authors.affiliation: Department of Internal Medicine II, Division of Hematology/Oncology, University Hospital of Würzburg, Würzburg, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Kapp
mesh_terms: D001786:Blood Glucose / Q000032:analysis; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000097:blood; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D006943:Hyperglycemia / Q000150:complications*; D009181:Mycoses / Q000209:etiology*; D012307:Risk Factors
chemical_list: D001786:Blood Glucose