title: Implications of the thyroid hormone on neuronal development with special emphasis on the calmodulin-kinase IV pathway.
abstract: Thyroid hormones influence brain development through regulation of gene expression. This is especially true for Ca2+-dependent regulation since a major pathway is controlled by the Ca2+/calmodulin-dependent protein kinase IV (CaMKIV) which in turn is induced by the thyroid hormone T3. In addition, CaMKIV is involved in regulation of alternative splicing of a number of protein isoforms, among them PMCA1a, the neuronal specific isoform of the plasma membrane calcium pump. On the other hand, hypothyroidism or CaMKIV deficiency can have a severe influence on brain development. This article is part of a Special Issue entitled: ECS Meeting edited by Claus Heizmann, Joachim Krebs and Jacques Haiech.
authors.affiliation: NMR-based Structural Biology, MPI for Biophysical Chemistry, Göttingen, Germany.
authors.forename: Joachim
authors.initials: J
authors.lastname: Krebs
mesh_terms: D017398:Alternative Splicing; D000818:Animals; D001921:Brain / Q000201:enzymology; D054734:Calcium-Calmodulin-Dependent Protein Kinase Type 4 / Q000378:metabolism*; D015870:Gene Expression; D006801:Humans; D009474:Neurons / Q000166:cytology* / Q000201:enzymology; D053499:Plasma Membrane Calcium-Transporting ATPases / Q000235:genetics / Q000378:metabolism; D013963:Thyroid Hormones / Q000502:physiology*
chemical_list: D013963:Thyroid Hormones; D054734:Calcium-Calmodulin-Dependent Protein Kinase Type 4; D053499:Plasma Membrane Calcium-Transporting ATPases
keywords: Alternative splicing; CaMKIV; Neuronal development; PMCA1a; Thyroid hormone