title: Dietary exposure to trace elements and health risk assessment in the region of Valencia, Spain: a total diet study.
abstract: Dietary exposure of the Valencian region population to lead, cadmium, inorganic arsenic (iAs), chromium, copper, tin and methylmercury (meHg) was assessed in a total diet study carried out in the region of Valencia in 2010-11. A total of 8100 food samples were collected and analysed. Occurrence data were combined with consumption data to estimate dietary exposure in adults (> 15 years of age) and young children (6-15 years of age). The estimated intake was calculated by a probabilistic approach. Average intake levels (optimistic scenario) for lead, iAs, chromium and tin were 0.21, 0.08, 1.79 and 1.87 µg kg-1bw day-1respectively; for Cd and meHg average intake levels were 0.77 and 0.54 µg kg-1bw week-1, respectively, and for Cu, 1.60 mg day-1. In terms of risk characterisation, the results showed that 2.84% of the adult population may exceed the BMDL10(benchmark dose lower confidence limit) established for Pb, which is linked to renal effects; whereas 28.01% of the young children population may exceed the BMDL01related to neurodevelopment effects. In addition, 8.47% of the adult population and 12.32% of young children exceeded the meHg tolerable weekly intake (TWI).
authors.affiliation: a Food Safety Research Area , Centre for Public Health Research (CSISP), FISABIO , Valencia , Spain.
authors.forename: Silvia
authors.initials: S
authors.lastname: Marín
authors.affiliation: a Food Safety Research Area , Centre for Public Health Research (CSISP), FISABIO , Valencia , Spain.|b Analytical Chemistry Department , University of Valencia , Valencia , Spain.
authors.forename: Olga
authors.initials: O
authors.lastname: Pardo
authors.affiliation: a Food Safety Research Area , Centre for Public Health Research (CSISP), FISABIO , Valencia , Spain.
authors.forename: Rosario
authors.initials: R
authors.lastname: Báguena
authors.affiliation: c Preventive Medicine and Public Health, Food Sciences, Toxicology and Forensic Medicine Department , University of Valencia , Valencia , Spain.
authors.forename: Guillermina
authors.initials: G
authors.lastname: Font
authors.affiliation: a Food Safety Research Area , Centre for Public Health Research (CSISP), FISABIO , Valencia , Spain.|b Analytical Chemistry Department , University of Valencia , Valencia , Spain.
authors.forename: Vicent
authors.initials: V
authors.lastname: Yusà
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D004032:Diet; D005260:Female; D005506:Food Contamination / Q000032:analysis*; D006801:Humans; D008297:Male; D008670:Metals / Q000008:administration & dosage* / Q000494:pharmacology*; D008875:Middle Aged; D018570:Risk Assessment; D013030:Spain; D055815:Young Adult
chemical_list: D008670:Metals
keywords: Exposure assessment; metal analysis; metal speciation; risk assessment; total diet studies