title: Whether a novel drug delivery system can overcome the problem of biofilms in respiratory diseases?
abstract: Biofilm comprises a community of microorganisms which form on medical devices and can lead to various threatening infections. It is a major concern in various respiratory diseases like cystic fibrosis, chronic obstructive pulmonary disease, etc. The treatment strategies for such infections are difficult due to the resistance of the microflora existing in the biofilms against various antimicrobial agents, thus posing threats to the patient population. The present era witnesses the beginning of research to understand the biofilm physiology and the associated microfloral diversity by applying -omics approaches. There is very limited information about how the deposition of biofilm on the respiratory devices and lung itself affects the drug delivered, the delivery system, and other implications. The present mini review summarizes the basic introduction to the biofilms and its avoidance using various drug delivery systems with special emphasis on the respiratory diseases. Understanding the approaches, principles, and modes of drug delivery involved in preventing biofilm deposition will be of interest to both biological and formulation scientists, thereby opening avenues to explore the new vistas in biofilm research for identifying better treatments for pulmonary infectious diseases.
authors.affiliation: Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, Lot 1 Kookaburra Circuit, New Lambton Heights, Newcastle, NSW, 2305, Australia. kamalpharmacist@gmail.com.|School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW, 2308, Australia. kamalpharmacist@gmail.com.
authors.forename: Kamal
authors.initials: K
authors.lastname: Dua
authors.affiliation: Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, Lot 1 Kookaburra Circuit, New Lambton Heights, Newcastle, NSW, 2305, Australia.|School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW, 2308, Australia.
authors.forename: Shakti D
authors.initials: SD
authors.lastname: Shukla
authors.affiliation: National Institute of Pharmaceutical Education and Research, Gandhinagar, Gujarat, 382355, India.
authors.forename: Rakesh K
authors.initials: RK
authors.lastname: Tekade
authors.affiliation: Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, Lot 1 Kookaburra Circuit, New Lambton Heights, Newcastle, NSW, 2305, Australia. philip.hansbro@newcastle.edu.au.|School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW, 2308, Australia. philip.hansbro@newcastle.edu.au.
authors.forename: Philip M
authors.initials: PM
authors.lastname: Hansbro
mesh_terms: D000818:Animals; D018441:Biofilms; D016503:Drug Delivery Systems; D004351:Drug Resistance; D006801:Humans; D012140:Respiratory Tract Diseases / Q000188:drug therapy*
keywords: Biofilms; Drug delivery; Pulmonary