title: Using Systems Genetics to Understanding the Etiology of Complex Disease.
abstract: Here, we discuss Systems Genetics applications for systematic evaluation of candidate causal genes together with follow-up bioinformatics pathway analysis. The aim of this chapter is to illustrate analytic procedures and we provide examples in the context of Type 1 diabetes (T1day), the risk of which is conferred by over 60 loci. We also describe the Type 1 Diabetes Systems Genetics website and provide a guide for its use and application to other diseases.
authors.affiliation: Centre for Diabetes Research, Harry Perkins Institute of Medical Research, The University of Western Australia, 6 Verdun Street, Nedlands, WA, 6009, Australia.
authors.forename: Ramesh
authors.initials: R
authors.lastname: Ram
authors.affiliation: Centre for Diabetes Research, Harry Perkins Institute of Medical Research, The University of Western Australia, 6 Verdun Street, Nedlands, WA, 6009, Australia. grant.morahan@uwa.edu.au.
authors.forename: Grant
authors.initials: G
authors.lastname: Morahan
mesh_terms: D019295:Computational Biology / Q000379:methods; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics / Q000378:metabolism; D015870:Gene Expression; D020022:Genetic Predisposition to Disease; D023281:Genomics / Q000379:methods; D006801:Humans; D020412:Multifactorial Inheritance; D009154:Mutation; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci; D019655:Quantitative Trait, Heritable; D064878:Web Browser
keywords: Cis-regulatory genes; Nonsynonymous genetic modifiers; Trans-regulatory genes; Use case Type 1 diabetes; Variants that affect gene expression