title: Molecular imaging for prostate cancer: Performance analysis of68Ga-PSMA PET/CT versus choline PET/CT.
abstract: BACKGROUND
  There is a need for a precise and reliable imaging to improve the management of prostate cancer. In recent years the PET/CT with choline has changed the handling of prostate cancer in Europe, and it is commonly used for initial stratification or for the diagnosis of a biochemical recurrence, although it does not lack limitations. Other markers are being tested, including the ligand of prostate-specific membrane antigen (PSMA), that seems to offer encouraging prospects. The goal of this piece of work was to critically review the role of choline and PSMA PET/CT in prostate cancer.
  
  
  METHODS
  A systematic literature review of databases PUBMED/MEDLINE and EMBASE was conducted searching for articles fully published in English on the PET marker in prostate cancer and its clinical application.
  It seems as 68Ga-PSMA PET/CT is better than PET/CT in prostate cancer to detect primary prostate lesions, initial metastases in the lymph nodes and recurrence. However, further research is required to obtain high-level tests. Also, other PET markers are studied. Moreover, the emergence of a new PET/MR camera could change the performance of PET imaging.
authors.affiliation: Departamento de Cirugía, Memorial Sloan Kettering Cancer Center, New York, NY, Estados Unidos; Servicio de Diagnóstico y Terapia por imagen, Memorial Sloan Kettering Cancer Center, New York, NY, Estados Unidos.
authors.forename: L
authors.initials: L
authors.lastname: Michaud
authors.affiliation: Servicio de Urología, Departamento de Cirugía, Memorial Sloan Kettering Cancer Center, New York, NY, Estados Unidos; Departamento de Urología, Weill Cornell Medical College, New York, NY, Estados Unidos. Electronic address: touijerk@mskcc.org.
authors.forename: K A
authors.initials: KA
authors.lastname: Touijer
mesh_terms: D002794:Choline; D004492:Edetic Acid / Q000031:analogs & derivatives*; D005709:Gallium Isotopes; D005710:Gallium Radioisotopes; D006801:Humans; D008297:Male; D057054:Molecular Imaging; D009842:Oligopeptides; D000072078:Positron Emission Tomography Computed Tomography; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging*
chemical_list: D005709:Gallium Isotopes; D005710:Gallium Radioisotopes; D009842:Oligopeptides; C000718244:gallium 68 PSMA-11; D004492:Edetic Acid; D002794:Choline
keywords: Antígeno de membrana específico de la próstata; Choline; Colina; Molecular imaging; Neoplasias prostáticas; Prostate specific membrane antigen; Prostatic neoplasms; Toma de imágenes molecular