title: Five New C19-Diterpenoid Alkaloids from Delphinium tianshanicum W.T.Wang.
abstract: Five new diterpenoid alkaloids, tianshanitines A-E (1 - 5), along with ten known compounds (6 - 15), were isolated from the EtOH extracts of the whole plant of Delphinium tianshanicum W.T.Wang. Their structures were determined based on extensive spectroscopic analyses, including 1D- and 2D-NMR, HR-ESI-MS, and the structure of tianshanitine C (3) was confirmed by X-ray diffraction analysis. Tianshanitine A (1) is the first example of natural diterpenoid alkaloid containing a benzoyl group at C(1) position. Tianshanitine B (2) is a rare natural diterpenoid alkaloid bearing a OH group at C(16) position. Compounds 1 - 5, 6, 8, 10, 12 and 14 were evaluated for cytotoxicity against HCT116, MCF-7 and HepG2 human cancer cell lines.
authors.affiliation: School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, Sichuan, P. R. China.|Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Material Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, Sichuan, P. R. China.
authors.forename: Ji-Fa
authors.initials: JF
authors.lastname: Zhang
authors.affiliation: School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, Sichuan, P. R. China.
authors.forename: Lian-Hai
authors.initials: LH
authors.lastname: Shan
authors.affiliation: School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, Sichuan, P. R. China.
authors.forename: Feng
authors.initials: F
authors.lastname: Gao
authors.affiliation: School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, Sichuan, P. R. China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Huang
authors.affiliation: School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, Sichuan, P. R. China.|Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Material Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, Sichuan, P. R. China.
authors.forename: Xian-Li
authors.initials: XL
authors.lastname: Zhou
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D031882:Delphinium / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D013057:Spectrum Analysis
chemical_list: D000470:Alkaloids; D000970:Antineoplastic Agents; D004224:Diterpenes
keywords: C19-Diterpenoid alkaloids; Cytotoxic activities; Delphinium tianshanicum; Tianshanitines