title: The effect of topical 5-flurouracil application post endoscopic inferior turbinoplasty.
abstract: OBJECTIVE
  Adhesions are the most common complication after nasal surgery and revision. 5-Fluorouracil (5-FU) reduces various adhesions and epithelial growth related complications. The aim of this study was to evaluate the effects of 5-flurouracil application in the nasal cavity after a multi-procedure nasal surgery in term of complications frequency.
  
  
  METHODS
  Institutional ethical approval was granted and a double-blinded prospective clinical trial was conducted to study the effect of 5-fu on post-operative complications. At the end of a combined endoscopic inferior turbinoplasty with one or more other nasal surgeries, 5-flurouracil-soaked cottonoid with 1mL of 5-flurouracil (5mg/mL) was applied in one side of nasal cavity and saline-soaked cottonoid was applied contralaterally and left for 5min. Patients were assessed over 2months postoperatively by a blinded observer in terms of adhesions, crustation, discharge, pain, discharge, loss of smell and other complications and nasal symptoms.
  
  
  RESULTS
  On the 1st follow up week postoperatively, adhesions were observed in (24 patients) 35%, bilateral in (6 patients) 9% and unilateral in (18 patients) 26%. Unilateral Adhesions were statistically significantly higher in control sides than those in 5-FU sides (22% vs 4% respectively) (p=0.025). Crustation, continued to statistically significantly diminish over time (p=0.035). On the 8th follow up week, adhesions reduction was still statistical significant at the 5-FU treated side (p=0.01).
  
  
  CONCLUSIONS
  5-FU is safe and effective in preventing adhesions formation when applied during combined endoscopic inferior turbinoplasty procedure with other nasal procedure surgery.
authors.affiliation: Otolaryngology department, Faculty of Medicine, Jordan University of Science and Technology, P O Box 3030, Irbid 22110, Jordan. Electronic address: amjadeee@yahoo.com.
authors.forename: Amjad F
authors.initials: AF
authors.lastname: Nuseir
authors.affiliation: Otolaryngology department, Faculty of Medicine, Jordan University of Science and Technology, P O Box 3030, Irbid 22110, Jordan.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Alsalem
authors.affiliation: Otolaryngology department, Faculty of Medicine, Jordan University of Science and Technology, P O Box 3030, Irbid 22110, Jordan.
authors.forename: Mouhamad
authors.initials: M
authors.lastname: Alzahr
authors.affiliation: Otolaryngology department, Faculty of Medicine, Jordan University of Science and Technology, P O Box 3030, Irbid 22110, Jordan.
authors.forename: Muthanna
authors.initials: M
authors.lastname: Ababneh
authors.affiliation: Otolaryngology department, Faculty of Medicine, Jordan University of Science and Technology, P O Box 3030, Irbid 22110, Jordan.
authors.forename: Ahmad I
authors.initials: AI
authors.lastname: Alomari
authors.affiliation: Otolaryngology department, Faculty of Medicine, Jordan University of Science and Technology, P O Box 3030, Irbid 22110, Jordan.
authors.forename: Firas
authors.initials: F
authors.lastname: Alzoubi
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000963:Antimetabolites / Q000008:administration & dosage / Q000627:therapeutic use*; D004311:Double-Blind Method; D004724:Endoscopy; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000188:drug therapy*; D011446:Prospective Studies; D000267:Tissue Adhesions / Q000188:drug therapy*; D016896:Treatment Outcome; D014420:Turbinates / Q000601:surgery*
chemical_list: D000963:Antimetabolites; D005472:Fluorouracil
keywords: 5-Fluorouracil; Adhesions; Endoscopic inferior turbinoplasty; Septoplasty