title: Transoral-transcervical oropharyngectomy without mandibulotomy, associated to fasciocutaneous radial forearm free-flap reconstruction, for oropharyngeal cancer: Postoperative course, oncologic and functional results, and prognostic factors.
abstract: OBJECTIVE
  To analyze postoperative course, oncologic and functional results and prognostic factors of transoral-transcervical oropharyngeal cancer surgery without mandibulotomy, associated to radial forearm free-flap reconstruction.
  
  
  METHODS
  Retrospective analysis of computerized medical records of all patients who underwent this type of surgery in our institution between 2004 and 2014. Predictive factors of oncologic and functional results were investigated on univariate and multivariate analyses.
  
  
  RESULTS
  Forty-four patients (37 male, 7 female; mean age, 62.3±9.3years) were included. Three-year overall, disease-specific and recurrence-free survival was 90%, 92% and 79%, respectively. Functional scores were satisfactory (normal or slight impairment) for feeding, speech and oral opening functions in 86%, 93% and 100% of cases, respectively. ASA score≥III had significantly negative impact on overall survival (P=0.005) and on feeding (P=0.01) and speech (P=0.01).
  
  
  CONCLUSIONS
  Transoral-transcervical oropharyngeal cancer surgery without mandibulotomy provided excellent oncologic and functional outcomes; it is an advantageous alternative to the conventional conservative transmandibular oropharyngectomy.
authors.affiliation: Institut universitaire de la face et du cou, 31, avenue de Valombrose, 06103 Nice, France.
authors.forename: M
authors.initials: M
authors.lastname: Roux
authors.affiliation: Institut universitaire de la face et du cou, 31, avenue de Valombrose, 06103 Nice, France.
authors.forename: O
authors.initials: O
authors.lastname: Dassonville
authors.affiliation: Département de biostatistiques, centre Antoine-Lacassagne, 33, avenue de Valombrose, 06189 Nice, France.
authors.forename: M
authors.initials: M
authors.lastname: Ettaiche
authors.affiliation: Institut universitaire de la face et du cou, 31, avenue de Valombrose, 06103 Nice, France.
authors.forename: G
authors.initials: G
authors.lastname: Poissonnet
authors.affiliation: Département d'anatomie pathologique, centre Antoine-Lacassagne, 33, avenue de Valombrose, 06189 Nice, France.
authors.forename: A
authors.initials: A
authors.lastname: Sudaka
authors.affiliation: Institut universitaire de la face et du cou, 31, avenue de Valombrose, 06103 Nice, France. Electronic address: alexandre.bozec@nice.unicancer.fr.
authors.forename: A
authors.initials: A
authors.lastname: Bozec
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D057286:Electronic Health Records; D005260:Female; D005500:Follow-Up Studies; D058752:Free Tissue Flaps; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D063168:Mandibular Osteotomy; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D009367:Neoplasm Staging; D009959:Oropharyngeal Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D010611:Pharyngectomy / Q000379:methods; D011379:Prognosis; D011884:Radius / Q000601:surgery; D019651:Plastic Surgery Procedures / Q000379:methods; D012189:Retrospective Studies; D016896:Treatment Outcome
keywords: Cancer; Functional results; Mandibulotomy; Oncologic results; Oropharynx; Surgery