title: Relationships betweenFTOrs9939609,MC4Rrs17782313, andPPARγrs1801282 polymorphisms and the occurrence of selected metabolic and hormonal disorders in middle-aged and elderly men - a preliminary study.
abstract: OBJECTIVE
  Metabolic disorders, including MetS, obesity, and lipid disorders, may be related to genetic factors. Metabolic disorders are associated with decreased TS levels in aging men. The aim of this study was to evaluate the relationship betweenFTOrs9939609,MC4Rrs17782313, andPPARγrs1801282 polymorphisms and the presence of MetS and its components, the concurrent lipid disorders, as well as sex hormone concentrations.
  
  
  METHODS
  This study involved 272 men of Caucasian descent aged 50-75 years. Lipid profile, including TCh, LDL, HDL, and TG, was evaluated by spectrophotometric method. Anthropometric measurements concerned WC and blood pressure. MetS was diagnosed according to the criteria of the IDF. Sex hormone profile, including TST, FTS, E2, DHEAS, and SHBG, was examined using enzyme-linked immunosorbent assay. Polymorphisms withinFTO,MC4R, andPPARγgenes were identified using polymerase chain reaction-restriction fragments length polymorphism.
  
  
  RESULTS
  This study did not show links between the analyzed genetic polymorphisms and the presence of MetS, T2DM, HT, and obesity. However, higher concentrations of TCh and LDL were found in men with theFTOrs9939609 polymorphism in the recessive mode of inheritance (P=0.03 andP=0.05, respectively). Lower WC was found to be associated withMC4Rrs17782313 gene inherited in the same model (P=0.005).
  
  
  CONCLUSIONS
  FTOrs9939609,MC4Rrs17782313, andPPARγrs1801282 polymorphisms seem to have little effect on the incidence of metabolic malfunctions and no effect on androgen-related disorders in the examined middle-aged and elderly men.
authors.affiliation: Department of Medical Rehabilitation.
authors.forename: Iwona
authors.initials: I
authors.lastname: Rotter
authors.affiliation: Department of Gerontobiology.
authors.forename: Karolina
authors.initials: K
authors.lastname: Skonieczna-Żydecka
authors.affiliation: Department of Biology and Medical Parasitology.
authors.forename: Danuta
authors.initials: D
authors.lastname: Kosik-Bogacka
authors.affiliation: Department of Gerontobiology.
authors.forename: Grażyna
authors.initials: G
authors.lastname: Adler
authors.affiliation: Department of Histology and Developmental Biology, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Rył
authors.affiliation: Department of Histology and Developmental Biology, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Maria
authors.initials: M
authors.lastname: Laszczyńska
mesh_terms: D000368:Aged; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO / Q000235:genetics*; D000886:Anthropometry; D001794:Blood Pressure; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D016015:Logistic Models; D008297:Male; D024821:Metabolic Syndrome / Q000235:genetics*; D008875:Middle Aged; D047495:PPAR gamma / Q000235:genetics*; D011044:Poland; D020641:Polymorphism, Single Nucleotide; D044105:Receptor, Melanocortin, Type 4 / Q000235:genetics*; D012307:Risk Factors; D044465:White People / Q000235:genetics*
chemical_list: C470072:MC4R protein, human; D047495:PPAR gamma; D044105:Receptor, Melanocortin, Type 4; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human
keywords: FTO; MC4R; PPARγ; aging men; genes; metabolic syndrome; sex hormones