title: Fetal thrombotic vasculopathy: A case report and literature review.
abstract: Fetal thrombotic vasculopathy is a recently described placental alteration with varying degrees of involvement and often associated with adverse perinatal outcomes. The diagnosis is made histologically and therefore is postnatal, which makes it a challenge in clinical practice.
  Case report and review of literature on the subject.
  The present case refers to a pregnant woman presenting fetal growth restriction, with poor obstetrical past, and sent late to our service. Even with weekly assessments of fetal vitality (fetal biophysical profile and Doppler velocimetry) and prenatal care, the patient progressed with fetal death at 36 weeks and 1 day. There was no association with inherited and acquired thrombophilia. Pathological examination of the placenta revealed fetal thrombotic vasculopathy.
  The fetal thrombotic vasculopathy may be associated with adverse perinatal outcomes including fetal death, but much remains to be studied regarding its pathogenesis. Diagnosis during pregnancy is not possible and there is still no proven treatment for this condition. Future studies are needed so that strategies can be developed to minimize the impact of fetal thrombotic vasculopathy.
authors.affiliation: MD - Resident Physician in Obstetrics and Gynecology, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (HC-FMUSP), São Paulo, SP, Brazil.
authors.forename: Ana Berquo
authors.initials: AB
authors.lastname: Peleja
authors.affiliation: PhD in Science (Obstetrics and Gynecology) from FMUSP. Assistant Physician, Department of Obstetrics, FMUSP, São Paulo, SP, Brazil.
authors.forename: Silvio
authors.initials: S
authors.lastname: Martinelli
authors.affiliation: MSc in Obstetrics from FMUSP. Assistant Physician, Department of Obstetrics, FMUSP, São Paulo, SP, Brazil.
authors.forename: Renata Lopes
authors.initials: RL
authors.lastname: Ribeiro
authors.affiliation: PhD and Habilitation (BR: Livre-docência) in Obstetrics and Gynecology from FMUSP. Associate Professor, Division of Obstetrics, Department of Obstetrics and Gynecology, FMUSP, São Paulo, SP, Brazil.
authors.forename: Roberto Eduardo
authors.initials: RE
authors.lastname: Bittar
authors.affiliation: PhD in Pathology from Universitat Ulm, Germany. Assistant Physician, Division of Pathological Anatomy, Department of Pathology, FMUSP, São Paulo, SP, Brazil.
authors.forename: Regina
authors.initials: R
authors.lastname: Schultz
authors.affiliation: PhD in Medicine (Obstetrics and Gynecology) from FMUSP. Associate Professor, Division of Obstetrics, Department of Obstetrics and Gynecology, FMUSP, São Paulo, SP, Brazil.
authors.forename: Rossana Pulcineli Vieira
authors.initials: RP
authors.lastname: Francisco
mesh_terms: D000328:Adult; D005260:Female; D005317:Fetal Growth Retardation / Q000473:pathology; D005865:Gestational Age; D006801:Humans; D066087:Perinatal Death; D010920:Placenta / Q000098:blood supply / Q000473:pathology; D010922:Placenta Diseases / Q000473:pathology*; D011247:Pregnancy; D013927:Thrombosis / Q000473:pathology*