title: Venlafaxine ameliorates the depression-like behaviors and hippocampal S100B expression in a rat depression model.
abstract: BACKGROUND
  Accumulating evidence has indicated that S100B may be involved in the pathophysiology of depression. No published study has examined the effect of the antidepressant drug venlafaxine on S100B in animal models of depression. This study investigated S100B expression in the hippocampus and assessed the effect of venlafaxine on S100B mRNA level and protein expression in rats exposed to chronic unpredictable mild stress (CUMS).
  
  
  METHODS
  Forty Sprague-Dawley rats were randomly divided into four groups as control, 0, 5 and 10 mg venlafaxine groups. The venlafaxine groups were exposed to CUMS from day 2 to day 43. Venlafaxine 0, 5 and 10 mg/kg were then administered from day 23 to day 43. We performed behavioral assessments with weight change, open-field and sucrose preference, and analyzed S100B protein expression and mRNA level in the hippocampus.
  
  
  RESULTS
  The CUMS led to a decrease in body weight, locomotor activity and sucrose consumption, but venlafaxine treatment (10 mg) reversed these CUMS-induced decreases Also, CUMS increased S100B protein expression and mRNA level in the hippocampus, but venlafaxine treatment (10 mg) significantly decreased S100B protein expression and mRNA level, which were significantly lower than the other treatment groups, without significant difference between the 10 mg venlafaxine and the control groups.
  
  
  CONCLUSIONS
  Our findings showed that venlafaxine treatment (10 mg) may improve the depression-like behaviors and decrease over-expression of S100B protein and mRNA in the hippocampus in a rat model of depression.
authors.affiliation: Department of Psychiatry, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, 453002, Henan, China.
authors.forename: Chang-Hong
authors.initials: CH
authors.lastname: Wang
authors.affiliation: Department of Psychiatry, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, 453002, Henan, China.
authors.forename: Jing-Yang
authors.initials: JY
authors.lastname: Gu
authors.affiliation: Department of Psychiatry, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, 453002, Henan, China.
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Zhang
authors.affiliation: Department of Psychiatry, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, 453002, Henan, China.
authors.forename: Jiao
authors.initials: J
authors.lastname: Dong
authors.affiliation: Standard Technological Co. Ltd. (Xinxiang Institute for New Medicine), Xinxiang, 453003, Henan, China.|Xinjiang Hongda Food & Beverage Co. Ltd., Xinjiang, 043102, Shanxi, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Psychiatry, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, 453002, Henan, China.
authors.forename: Ying-Li
authors.initials: YL
authors.lastname: Zhang
authors.affiliation: Department of Psychiatry, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, 453002, Henan, China.
authors.forename: Qiu-Fen
authors.initials: QF
authors.lastname: Ning
authors.affiliation: Department of Psychiatry, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, 453002, Henan, China.
authors.forename: Xiao-Wen
authors.initials: XW
authors.lastname: Shan
authors.affiliation: Department of Child and Adolescent, Public Health College, Zhengzhou University, 100 Kexue Road, Zhengzhou, 450001, Henan, China. liyanzzu2009@126.com.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
mesh_terms: D000818:Animals; D018687:Antidepressive Agents, Second-Generation / Q000494:pharmacology / Q000627:therapeutic use; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D003863:Depression / Q000188:drug therapy* / Q000378:metabolism* / Q000523:psychology; D004195:Disease Models, Animal; D005786:Gene Expression Regulation; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D064568:S100 Calcium Binding Protein beta Subunit / Q000037:antagonists & inhibitors / Q000096:biosynthesis* / Q000235:genetics; D013315:Stress, Psychological / Q000188:drug therapy / Q000378:metabolism / Q000523:psychology; D000069470:Venlafaxine Hydrochloride / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D018687:Antidepressive Agents, Second-Generation; D064568:S100 Calcium Binding Protein beta Subunit; C579158:S100b protein, rat; D000069470:Venlafaxine Hydrochloride
keywords: Depression; Hippocampus; S100B protein; Stress; Venlafaxine