title: Successful T-cell Replete Hematopoietic Stem Cell Boost Without Conditioning for Late Graft Failure.
abstract: Late graft failure is a rare but significant complication after allogeneic stem cell transplantation, which is often complicated by severe infections. We report a case of late graft failure, which was successfully treated with a T-cell replete hematopoietic stem cell boost without conditioning that induced rapid engraftment and relieved the patient of infection. Discontinuation of immunosuppressants and nilotinib administration suppressed the host cells. Achieving full donor chimerism allowed us to administer a peripheral blood stem cell boost without conditioning.
authors.affiliation: Department of Hematology, Hakodate Municipal Hospital, Hakodate, Japan. Electronic address: yutsutsu@shore.ocn.ne.jp.
authors.forename: Y
authors.initials: Y
authors.lastname: Tsutsumi
authors.affiliation: Department of Hematology, Hakodate Municipal Hospital, Hakodate, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tateno
authors.affiliation: Department of Hematology, Hakodate Municipal Hospital, Hakodate, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Ito
authors.affiliation: Department of Hematology, Hakodate Municipal Hospital, Hakodate, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Shiratori
authors.affiliation: Department of Hematology, Hokkaido Graduate School of Medicine, Sapporo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Teshima
mesh_terms: D005260:Female; D006086:Graft vs Host Disease / Q000601:surgery*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods*; D006412:Hematopoietic Stem Cells; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D012086:Reoperation; D019172:Transplantation Conditioning; D014184:Transplantation, Homologous
chemical_list: D007166:Immunosuppressive Agents