title: Modelling the cost-effectiveness of catch-up 'MenB' (Bexsero) vaccination in England.
abstract: We assessed the cost-effectiveness of offering catch-up vaccination with Bexsero against meningococcal disease to children too old to receive the vaccine under the recently introduced infant programme. Offering catch-up vaccination to increasingly older children is less economically attractive because of declining disease burden. We estimate catch-up vaccination of 1year old children could be cost-effective, incremental on the infant programme with a vaccine price of ⩽£8 per dose. Extending vaccination to 2year olds could only be cost-effective (incremental on infant and 1year old catch-up) with a vaccine price of ⩽£3 per dose and was not cost-effective in sensitivity analyses with more conservative vaccine assumptions. Extending catch-up further to 3-4year olds was not cost-effective. Employing the current criteria for assessing vaccines, our models suggest that even with low vaccine prices only catch-up vaccination in 1year old children could be cost-effective, when considered incrementally on the infant programme.
authors.affiliation: School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, England, United Kingdom. Electronic address: hannah.christensen@bristol.ac.uk.
authors.forename: Hannah
authors.initials: H
authors.lastname: Christensen
authors.affiliation: Disease Dynamics Unit, Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, England, United Kingdom. Electronic address: clt56@cam.ac.uk.
authors.forename: Caroline L
authors.initials: CL
authors.lastname: Trotter
mesh_terms: D000367:Age Factors; D002675:Child, Preschool; D003362:Cost-Benefit Analysis; D004739:England / Q000453:epidemiology; D006801:Humans; D007223:Infant; D008589:Meningococcal Infections / Q000191:economics* / Q000453:epidemiology / Q000517:prevention & control*; D022401:Meningococcal Vaccines / Q000008:administration & dosage* / Q000191:economics*; D014611:Vaccination / Q000191:economics* / Q000706:statistics & numerical data*
chemical_list: C570015:4CMenB vaccine; D022401:Meningococcal Vaccines
keywords: Catch-up; Cost-effectiveness; Group B; Meningococcal disease; Vaccination