title: Dementia Predictors in Parkinson Disease: A Validation Study.
abstract: In a prospective study, we recently discovered 8 clinical predictors of dementia in Parkinson's disease. Here, we validate these dementia predictors using two additional prospective cohorts (n = 134). After a 3.6-year follow-up, 35/134 developed dementia (7.2% per year). When confirming individual variables, 5/8 were significantly associated with dementia in the validation cohort. These included age, male sex, baseline RBD, orthostatic hypotension, and MCI. Bilateral onset, hallucinations and falls/freezing did not significantly predict dementia; however, point estimates of OR were all >1. In all cohorts, the strongest determinant for dementia development was the co-existence of RBD, MCI and orthostatic hypotension at baseline.
authors.affiliation: Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.
authors.forename: Julius B M
authors.initials: JB
authors.lastname: Anang
authors.affiliation: Department of Brain and Neurosciences, Division of Neurology, Faculty of Medicine, Tottori University, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Nomura
authors.affiliation: Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.
authors.forename: Silvia Rios
authors.initials: SR
authors.lastname: Romenets
authors.affiliation: Department of Brain and Neurosciences, Division of Neurology, Faculty of Medicine, Tottori University, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Nakashima
authors.affiliation: Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré-Coeur de Montréal, Montréal, QC, Canada.|Department of Psychology, Université du Québec à Montréal, Montreal, QC, Canada.
authors.forename: Jean-Francois
authors.initials: JF
authors.lastname: Gagnon
authors.affiliation: Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.|Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré-Coeur de Montréal, Montréal, QC, Canada.
authors.forename: Ronald B
authors.initials: RB
authors.lastname: Postuma
mesh_terms: D000368:Aged; D060825:Cognitive Dysfunction / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology*; D003704:Dementia / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007024:Hypotension, Orthostatic / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications / Q000453:epidemiology / Q000503:physiopathology*; D011379:Prognosis; D020187:REM Sleep Behavior Disorder / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology*
keywords: Dementia; REM sleep behavior disorder; mild cognitive 
  impairment; prediction