title: Chromosome Segregation: Reconstituting the Kinetochore.
abstract: Faithful chromosome segregation is accomplished by attachment of chromosomes to spindle microtubules using the kinetochore. In a major step forward in understanding the functional and structural complexity of kinetochores, a 21-subunit human centromere - kinetochore complex has been reconstituted entirely from purified components, recreating the connection between DNA and microtubule.
authors.affiliation: Department of Biochemistry, Stanford Medical School, Stanford, CA, USA.
authors.forename: Frederick G
authors.initials: FG
authors.lastname: Westhorpe
authors.affiliation: Department of Biochemistry, Stanford Medical School, Stanford, CA, USA. Electronic address: astraigh@stanford.edu.
authors.forename: Aaron F
authors.initials: AF
authors.lastname: Straight
mesh_terms: D020090:Chromosome Segregation / Q000502:physiology*; D056890:Eukaryota / Q000166:cytology; D018386:Kinetochores / Q000502:physiology*; D008870:Microtubules; D008938:Mitosis / Q000502:physiology*