title: Preparation of hollow core/shell Fe3O4@graphene oxide composites as magnetic targeting drug nanocarriers.
abstract: A main challenge for anticancer drugs is that the drugs can not arrive the cancer tissue at right time. In this work, a magnetic targeting nanoparticle based on hollow Fe3O4/graphene oxide (Fe3O4/GO) was developed as a potential tumor targeting drug carriers. The morphology results showed the Fe3O4nanoparticles were uniformly wrapped by graphene oxide. After coating with graphene oxide, the Fe3O4/GO showed a higher saturation magnetization of 71.47 emu g-1as compared to neat Fe3O4nanoparticles. The drug loading and releasing experiment indicated the obtained Fe3O4/GO has a good loading capacity of of 0.41 mg mg-1for 5-fluorouracil (5-FU) and a positive sensitive of acidic atmosphere. The CCK-8 assays of CMEC viability demonstrated the hollow Fe3O4/GO nanocarriers do not statistically exhibit toxicity with the concentration increasing from 2.5 to 40 μg mL-1in vitro. These results suggested the prepared Fe3O4/GO has a potential application in anticancer drugs nanocarriers.
authors.affiliation: a College of Chemistry and Chemical Engineering , Hunan University , Changsha , China.
authors.forename: Junmei
authors.initials: J
authors.lastname: Wang
authors.affiliation: b Institute of Applied of Bioresource Research, College of Animal Science , Zhejiang University , Hangzhou , China.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Fang
authors.affiliation: a College of Chemistry and Chemical Engineering , Hunan University , Changsha , China.
authors.forename: Pan
authors.initials: P
authors.lastname: Fang
authors.affiliation: a College of Chemistry and Chemical Engineering , Hunan University , Changsha , China.
authors.forename: Xian
authors.initials: X
authors.lastname: Li
authors.affiliation: a College of Chemistry and Chemical Engineering , Hunan University , Changsha , China.
authors.forename: Shijie
authors.initials: S
authors.lastname: Wu
authors.affiliation: c Advanced Materials for Nano-Bio Applications, School of Ophthalmology and Optometry , WenZhou Medical University , Wenzhou , China.
authors.forename: Wenjing
authors.initials: W
authors.lastname: Zhang
authors.affiliation: a College of Chemistry and Chemical Engineering , Hunan University , Changsha , China.
authors.forename: Sufang
authors.initials: S
authors.lastname: Li
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers / Q000737:chemistry* / Q000633:toxicity; D065546:Drug Liberation; D005472:Fluorouracil / Q000737:chemistry; D006108:Graphite / Q000737:chemistry*; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D010087:Oxides / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D058185:Magnetite Nanoparticles; D010087:Oxides; D006108:Graphite; D005472:Fluorouracil
keywords: Hollow Fe3O4 sphere; drug delivery; drug nanocarrier; graphene oxide; magenetic particle