title: Factors Associated With the Use of Radiation Therapy in Patients With Stage III Non-small Cell Lung Cancer in Alberta, Canada: A Population-based Study.
abstract: BACKGROUND
  Cancer care in Alberta, Canada is publicly funded and provides patients with access to health care facilities and providers. The distribution of patients and health services across Alberta presents challenges to the delivery of cancer care, especially radiation therapy. In this study, we examined the association between patient and health system factors, the use of radiation therapy and survival outcomes in patients with stage III non-small cell lung cancer (NSCLC).
  
  
  METHODS
  The provincial cancer registry was used to identify all patients who presented with clinical stage III NSCLC, diagnosed from 2005 to 2007, in Alberta. Patient characteristics, diagnostic method, treatment modality and treatment outcomes were collected from provincial health information systems for analyses. Factors influencing overall survival (OS) were analyzed using Cox proportional hazards models.
  
  
  RESULTS
  Nine hundred twenty-nine patients were identified. Sixty-two percent of patients received radiation therapy (RT) as part of their initial cancer treatment and had a median OS of 1.04 vs. 0.34 years with a hazard ratio (HR) of 0.54. On multivariable analysis, patients who were less likely to receive any therapy were older, had higher comorbidity scores and were registered in community cancer centers without radiation therapy infrastructure. Patients registered in tertiary cancer centers had a higher likelihood of accessing multimodality treatment than patients in community centers, with a statistical significance of P<0.001 after correcting for age, gender, histology, substage, and comorbidity.
  
  
  CONCLUSIONS
  Improving access to radiotherapy treatment for patients presenting to non-radiation therapy centers at diagnosis has the potential to decrease variations in cancer care and improve cancer control outcomes in clinical stage III NSCLC.
authors.affiliation: Radiation Oncology, Central Alberta Cancer Center.
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: Liu
authors.affiliation: Department of Oncology, Tom Baker Cancer Centre, Calgary.
authors.forename: Marc
authors.initials: M
authors.lastname: Kerba
authors.affiliation: Department of Oncology, Tom Baker Cancer Centre, Calgary.
authors.forename: Gerald
authors.initials: G
authors.lastname: Lim
authors.affiliation: Radiation Oncology, Cross Cancer Center, University of Alberta.
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Gabos
authors.affiliation: Department of Oncology, Tom Baker Cancer Centre, Calgary.
authors.forename: Ivo A
authors.initials: IA
authors.lastname: Olivotto
authors.affiliation: Oncology, Cross Cancer Institute, University of Alberta.
authors.forename: Anil Abraham
authors.initials: AA
authors.lastname: Joy
authors.affiliation: Oncology, Cross Cancer Institute, University of Alberta.
authors.forename: Wilson
authors.initials: W
authors.lastname: Roa
authors.affiliation: Department of Epidemiology and Cancer Registry, Cancer Care Manitoba, University of Manitoba, Canada.
authors.forename: Zoann
authors.initials: Z
authors.lastname: Nugent
authors.affiliation: Radiation Oncology, Tom Baker Cancer Centre, Calgary.
authors.forename: Harold
authors.initials: H
authors.lastname: Lau
keywords: overall survival; practice pattern; resource of health facility; stage iii non-small cell lung cancer