title: Contrast-enhanced transrectal ultrasound for prediction of prostate cancer aggressiveness: The role of normal peripheral zone time-intensity curves.
abstract: To assess the role of time-intensity curves (TICs) of the normal peripheral zone (PZ) in the identification of biopsy-proven prostate nodules using contrast-enhanced transrectal ultrasound (CETRUS). This study included 132 patients with 134 prostate PZ nodules. Arrival time (AT), peak intensity (PI), mean transit time (MTT), area under the curve (AUC), time from peak to one half (TPH), wash in slope (WIS) and time to peak (TTP) were analyzed using multivariate linear logistic regression and receiver operating characteristic (ROC) curves to assess whether combining nodule TICs with normal PZ TICs improved the prediction of prostate cancer (PCa) aggressiveness. The PI, AUC (p < 0.001 for both), MTT and TPH (p = 0.011 and 0.040 respectively) values of the malignant nodules were significantly higher than those of the benign nodules. Incorporating the PI and AUC values (both, p < 0.001) of the normal PZ TIC, but not the MTT and TPH values (p = 0.076 and 0.159 respectively), significantly improved the AUC for prediction of malignancy (PI: 0.784-0.923; AUC: 0.758-0.891) and assessment of cancer aggressiveness (p < 0.001). Thus, all these findings indicate that incorporating normal PZ TICs with nodule TICs in CETRUS readings can improve the diagnostic accuracy for PCa and cancer aggressiveness assessment.
authors.affiliation: Department of Ultrasound, Affiliated Hospital of Nanjing University of TCM, Nanjing 210029, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Huang
authors.affiliation: Department of Ultrasound, Affiliated Hospital of Nanjing University of TCM, Nanjing 210029, China.
authors.forename: Zheng-Qiu
authors.initials: ZQ
authors.lastname: Zhu
authors.affiliation: Department of Ultrasound, Affiliated Hospital of Nanjing University of TCM, Nanjing 210029, China.
authors.forename: Zheng-Guo
authors.initials: ZG
authors.lastname: Zhou
authors.affiliation: Department of Radiology, Affiliated Hospital of Nanjing University of TCM, Nanjing 210029, China.
authors.forename: Ling-Shan
authors.initials: LS
authors.lastname: Chen
authors.affiliation: Department of Pathology, Affiliated Hospital of Nanjing University of TCM, Nanjing 210029, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Zhao
authors.affiliation: Department of Urology, Affiliated Hospital of Nanjing University of TCM, Nanjing 210029, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Ultrasound, Affiliated Hospital of Nanjing University of TCM, Nanjing 210029, China.
authors.forename: Hong-Bo
authors.initials: HB
authors.lastname: Li
authors.affiliation: Department of Ultrasound, Affiliated Hospital of Nanjing University of TCM, Nanjing 210029, China.|Department of Urology, Affiliated Hospital of Nanjing University of TCM, Nanjing 210029, China.
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Yin
mesh_terms: D000368:Aged; D003287:Contrast Media; D006801:Humans; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D012372:ROC Curve; D015203:Reproducibility of Results; D018084:Ultrasonography, Interventional / Q000379:methods
chemical_list: D003287:Contrast Media