title: Diverse Strategies Used by Picornaviruses to Escape Host RNA Decay Pathways.
abstract: To successfully replicate, viruses protect their genomic material from degradation by the host cell. RNA viruses must contend with numerous destabilizing host cell processes including mRNA decay pathways and viral RNA (vRNA) degradation resulting from the antiviral response. Members of thePicornaviridaefamily of small RNA viruses have evolved numerous diverse strategies to evade RNA decay, including incorporation of stabilizing elements into vRNA and re-purposing host stability factors. Viral proteins are deployed to disrupt and inhibit components of the decay machinery and to redirect decay machinery to the advantage of the virus. This review summarizes documented interactions of picornaviruses with cellular RNA decay pathways and processes.
authors.affiliation: Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, CA 92697, USA. wullmer@uci.edu.
authors.forename: Wendy
authors.initials: W
authors.lastname: Ullmer
authors.affiliation: Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, CA 92697, USA. blsemler@uci.edu.
authors.forename: Bert L
authors.initials: BL
authors.lastname: Semler
mesh_terms: D000818:Animals; D054884:Host-Pathogen Interactions; D006801:Humans; D057131:Immune Evasion; D010849:Picornaviridae / Q000276:immunology* / Q000502:physiology*; D020871:RNA Stability; D012367:RNA, Viral / Q000378:metabolism*; D014764:Viral Proteins / Q000378:metabolism
chemical_list: D012367:RNA, Viral; D014764:Viral Proteins
keywords: Picornaviridae; RNA degradation; RNA stability; RNase L; coxsackievirus; deadenylase; human rhinovirus; mRNA decay; picornavirus; poliovirus