title: Single Cell Microgel Based Modular Bioinks for Uncoupled Cellular Micro- and Macroenvironments.
abstract: Modular bioinks based on single cell microgels within distinct injectable prepolymers enable uncoupling of biomaterials' micro- and macroenvironments. These inks allow biofabrication of 3D constructs that recapitulate the multiscale modular design of native tissues with a single cell resolution. This approach represents a major step forward in endowing engineered constructs with the multifunctionality that underlies the behavior of native tissues.
authors.affiliation: Department of Developmental BioEngineering, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Drienerlolaan 5, 7500AE, Enschede, The Netherlands.
authors.forename: Tom
authors.initials: T
authors.lastname: Kamperman
authors.affiliation: Department of Developmental BioEngineering, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Drienerlolaan 5, 7500AE, Enschede, The Netherlands.
authors.forename: Sieger
authors.initials: S
authors.lastname: Henke
authors.affiliation: BIOS Lab on a Chip group, MESA+ Institute for Nanotechnology, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, 7500AE, Enschede, The Netherlands.
authors.forename: Albert
authors.initials: A
authors.lastname: van den Berg
authors.affiliation: Biomaterials Innovation Research Center, Brigham and Women's Hospital, Harvard Medical School, 02139, Cambridge, MA, USA.|Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, 02139, Cambridge, MA, USA.|Wyss Institute for Biologically Inspired Engineering, Harvard University, 02115, Boston, MA, USA.
authors.forename: Su Ryon
authors.initials: SR
authors.lastname: Shin
authors.affiliation: Biomaterials Innovation Research Center, Brigham and Women's Hospital, Harvard Medical School, 02139, Cambridge, MA, USA.|Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, 02139, Cambridge, MA, USA.|Wyss Institute for Biologically Inspired Engineering, Harvard University, 02115, Boston, MA, USA.
authors.forename: Ali
authors.initials: A
authors.lastname: Tamayol
authors.affiliation: Biomaterials Innovation Research Center, Brigham and Women's Hospital, Harvard Medical School, 02139, Cambridge, MA, USA.|Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, 02139, Cambridge, MA, USA.|Wyss Institute for Biologically Inspired Engineering, Harvard University, 02115, Boston, MA, USA.|Department of Physics, King Abdulaziz University, 21589, Jeddah, Saudi Arabia.|Department of Bioindustrial Technologies, College of Animal Bioscience and Technology, Konkuk University, Hwayang-dong, Gwangjin-gu, Seoul, 143-701, Republic of Korea.
authors.forename: Ali
authors.initials: A
authors.lastname: Khademhosseini
authors.affiliation: Department of Developmental BioEngineering, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Drienerlolaan 5, 7500AE, Enschede, The Netherlands.
authors.forename: Marcel
authors.initials: M
authors.lastname: Karperien
authors.affiliation: Department of Developmental BioEngineering, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Drienerlolaan 5, 7500AE, Enschede, The Netherlands.|Biomaterials Innovation Research Center, Brigham and Women's Hospital, Harvard Medical School, 02139, Cambridge, MA, USA.|Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, 02139, Cambridge, MA, USA.
authors.forename: Jeroen
authors.initials: J
authors.lastname: Leijten
mesh_terms: D000818:Animals; D002417:Cattle; D019902:Chondrocytes / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000378:metabolism*; D055153:Stem Cell Niche; D023822:Tissue Engineering
keywords: biofabrication; droplet microfluidics; multiscale hierarchical materials; single cell encapsulation; tissue engineering