title: Blueberry Anthocyanin-Enriched Extracts Attenuate Fine Particulate Matter (PM2.5)-Induced Cardiovascular Dysfunction.
abstract: Blueberry anthocyanin-enriched extracts (BAE) at three doses (0.5, 1.0, and 2.0 g/kg) were administered by oral gavage to rats exposed to 10 mg/kg fine particulate matter (PM2.5) three times a week. A positive control group was exposed to PM2.5without BAE treatment. We analyzed heart rate (HR), electrocardiogram (ECG), and histopathology, and biomarkers of cardiovascular system injuries, systemic inflammation, oxidative stress, endothelial function, and apoptosis. Results indicated that BAE, particularly at 1.0 g/kg, improved ECG and decreased cytokine levels in PM2.5-exposed rats. These changes were accompanied by an increase in interleukin 10 levels and superoxide dismutase activity in heart tissue and Bcl-2 protein expression, as well as a decrease in interleukin 6, malondialdehyde, endothelin 1, and angiotensin II levels and a reduction in Bax protein expression. This study demonstrates that BAE at certain doses can protect the cardiovascular system from PM2.5-induced damage.
authors.affiliation: School of Public Health, Guangxi Medical University , Nanning 530021, China.|Department of Nutrition, Tianjin Institute of Health and Environmental Medicine , Tianjin 300050, China.
authors.forename: Ziyu
authors.identifier: http://orcid.org/0000-0002-7841-0072
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Nutrition, Tianjin Institute of Health and Environmental Medicine , Tianjin 300050, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Pang
authors.affiliation: Department of Nutrition, Tianjin Institute of Health and Environmental Medicine , Tianjin 300050, China.
authors.forename: Congcong
authors.initials: C
authors.lastname: He
authors.affiliation: Department of Nutrition, Tianjin Institute of Health and Environmental Medicine , Tianjin 300050, China.
authors.forename: Yibo
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Nutrition, Tianjin Institute of Health and Environmental Medicine , Tianjin 300050, China.
authors.forename: Yugang
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: School of Public Health, Guangxi Medical University , Nanning 530021, China.|Department of Nutrition, Tianjin Institute of Health and Environmental Medicine , Tianjin 300050, China.
authors.forename: Changjiang
authors.initials: C
authors.lastname: Guo
mesh_terms: D000393:Air Pollutants / Q000633:toxicity*; D000818:Animals; D000872:Anthocyanins / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D029798:Blueberry Plants / Q000378:metabolism*; D016207:Cytokines / Q000378:metabolism; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects; D015850:Interleukin-6 / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D052638:Particulate Matter / Q000633:toxicity*; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000393:Air Pollutants; D000872:Anthocyanins; D016207:Cytokines; D015850:Interleukin-6; D052638:Particulate Matter; D010936:Plant Extracts; D008315:Malondialdehyde; D013482:Superoxide Dismutase
keywords: blueberry anthocyanin-enriched extracts; cardiovascular disease; fine particulate matter; inflammation; oxidative stress