title: A combined cICA-EEMD analysis of EEG recordings from depressed or schizophrenic patients during olfactory stimulation.
abstract: We propose a combination of a constrained independent component analysis (cICA) with an ensemble empirical mode decomposition (EEMD) to analyze electroencephalographic recordings from depressed or schizophrenic subjects during olfactory stimulation.
  
  
  
  EEMD serves to extract intrinsic modes (IMFs) underlying the recorded EEG time. The latter then serve as reference signals to extract the most similar underlying independent component within a constrained ICA. The extracted modes are further analyzed considering their power spectra.
  
  
  
  The analysis of the extracted modes reveals clear differences in the related power spectra between the disease characteristics of depressed and schizophrenic patients. Such differences appear in the high frequency γ-band in the intrinsic modes, but also in much more detail in the low frequency range in the α-, θ- and δ-bands.
  
  
  
  The proposed method provides various means to discriminate both disease pictures in a clinical environment.
authors.affiliation: CIML Group, Biophysics, University of Regensburg, 93040 Regensburg, Germany.
authors.forename: Th
authors.initials: T
authors.lastname: Götz
authors.forename: L
authors.initials: L
authors.lastname: Stadler
authors.forename: G
authors.initials: G
authors.lastname: Fraunhofer
authors.forename: A M
authors.initials: AM
authors.lastname: Tomé
authors.forename: H
authors.initials: H
authors.lastname: Hausner
authors.forename: E W
authors.initials: EW
authors.lastname: Lang
mesh_terms: D000328:Adult; D001921:Brain / Q000503:physiopathology; D003863:Depression / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology*; D004569:Electroencephalography / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D000857:Olfaction Disorders / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology*; D055696:Olfactory Perception; D025341:Principal Component Analysis; D015203:Reproducibility of Results; D012559:Schizophrenia / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology*; D012680:Sensitivity and Specificity; D055815:Young Adult