title: Phytic acid/graphene oxide nanocomposites modified electrode for electrochemical sensing of dopamine.
abstract: An electrochemical sensor for determining dopamine was developed by modifying phytic acid/graphene oxide (PA/GO) nanocomposites onto a glassy carbon electrode (GCE). PA functionalized GO was prepared by an ultra-sonication method. Subsequently, the PA/GO nanocomposites were drop-casted on a glassy carbon substrate. The structural feature of the PA/GO modified GCE was confirmed by attenuated total reflection infrared (ATR-IR) spectroscopy. The proposed electrochemical sensor was applied to detect various concentrations of DA by differential pulse voltammetry (DPV). The PA/GO/GCE was considered to be highly sensitive to DA in the range of 0.05-10μM. In addition, the PA/GO/GCE demonstrated high electrochemical selectivity toward DA in the presence of ascorbic acid (AA) and uric acid (UA). The prepared electrochemical DA sensor was applied for detection of DA in dopamine hydrochloride injection and spiked samples of human urine with satisfactory results.
authors.affiliation: Key Laboratory for Colloid and Interface Chemistry of State Education Ministry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China.
authors.forename: Donglei
authors.initials: D
authors.lastname: Wang
authors.affiliation: Key Laboratory for Colloid and Interface Chemistry of State Education Ministry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Xu
authors.affiliation: Key Laboratory for Colloid and Interface Chemistry of State Education Ministry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China.
authors.forename: Jiajie
authors.initials: J
authors.lastname: Hu
authors.affiliation: Key Laboratory for Colloid and Interface Chemistry of State Education Ministry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China. Electronic address: mlin@sdu.edu.cn.
authors.forename: Meng
authors.initials: M
authors.lastname: Lin
mesh_terms: D004298:Dopamine / Q000652:urine*; D055664:Electrochemical Techniques / Q000379:methods*; D004566:Electrodes; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D053761:Nanocomposites / Q000737:chemistry*; D010833:Phytic Acid / Q000737:chemistry*
chemical_list: D006108:Graphite; D010833:Phytic Acid; D004298:Dopamine
keywords: Dopamine; Electrochemical sensor; Graphene oxide; Nanocomposites; Phytic acid