title: Endothelial Progenitor Cells Physiology and Metabolic Plasticity in Brain Angiogenesis and Blood-Brain Barrier Modeling.
abstract: Currently, there is a considerable interest to the assessment of blood-brain barrier (BBB) development as a part of cerebral angiogenesis developmental program. Embryonic and adult angiogenesis in the brain is governed by the coordinated activity of endothelial progenitor cells, brain microvascular endothelial cells, and non-endothelial cells contributing to the establishment of the BBB (pericytes, astrocytes, neurons). Metabolic and functional plasticity of endothelial progenitor cells controls their timely recruitment, precise homing to the brain microvessels, and efficient support of brain angiogenesis. Deciphering endothelial progenitor cells physiology would provide novel engineering approaches to establish adequate microfluidically-supported BBB models and brain microphysiological systems for translational studies.
authors.affiliation: Research Institute of Molecular Medicine & Pathobiochemistry, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky Krasnoyarsk, Russia.
authors.forename: Natalia A
authors.initials: NA
authors.lastname: Malinovskaya
authors.affiliation: Research Institute of Molecular Medicine & Pathobiochemistry, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky Krasnoyarsk, Russia.
authors.forename: Yulia K
authors.initials: YK
authors.lastname: Komleva
authors.affiliation: Research Institute of Molecular Medicine & Pathobiochemistry, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky Krasnoyarsk, Russia.
authors.forename: Vladimir V
authors.initials: VV
authors.lastname: Salmin
authors.affiliation: Research Institute of Molecular Medicine & Pathobiochemistry, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky Krasnoyarsk, Russia.
authors.forename: Andrey V
authors.initials: AV
authors.lastname: Morgun
authors.affiliation: Research Institute of Molecular Medicine & Pathobiochemistry, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky Krasnoyarsk, Russia.
authors.forename: Anton N
authors.initials: AN
authors.lastname: Shuvaev
authors.affiliation: Research Institute of Molecular Medicine & Pathobiochemistry, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky Krasnoyarsk, Russia.
authors.forename: Yulia A
authors.initials: YA
authors.lastname: Panina
authors.affiliation: Research Institute of Molecular Medicine & Pathobiochemistry, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky Krasnoyarsk, Russia.
authors.forename: Elizaveta B
authors.initials: EB
authors.lastname: Boitsova
authors.affiliation: Research Institute of Molecular Medicine & Pathobiochemistry, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky Krasnoyarsk, Russia.
authors.forename: Alla B
authors.initials: AB
authors.lastname: Salmina
keywords: Angiogenesis; Nicotinamide adenine dinucleotide (NAD+); blood-brain barrier (BBB); endothelial progenitor cells; neurovascular unit