title: Microstructure, mechanical behavior and biocompatibility of powder metallurgy Nb-Ti-Ta alloys as biomedical material.
abstract: Microstructures, mechanical properties, apatite-forming ability and in vitro experiments were studied for Nb-25Ti-xTa (x=10, 15, 20, 25, 35at.%) alloys fabricated by powder metallurgy. It is confirmed that the alloys could achieve a relative density over 80%. Meanwhile, the increase in Ta content enhances the tensile strength, elastic modulus and hardness of the as-sintered alloys. When increasing the sintering temperatures, the microstructure became more homogeneous for β phase, resulting in a decrease in the modulus and strength. Moreover, the alloys showed a good biocompatibility due to the absence of cytotoxic elements, and were suitable for apatite formation and cell adhesion. In conclusion, Nb-25Ti-xTa alloys are potentially useful in biomedical applications with their mechanical and biological properties being evaluated in this work.
authors.affiliation: State Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083, PR China.
authors.forename: Jue
authors.initials: J
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083, PR China.
authors.forename: Lin
authors.initials: L
authors.lastname: Chang
authors.affiliation: College of Materials Science and Engineering, Hunan University, Changsha 410082, China; Hunan Province Key Laboratory for Spray Deposition Technology and Application, Hunan University, Changsha 410082, China.
authors.forename: Hairong
authors.initials: H
authors.lastname: Liu
authors.affiliation: College of Materials Science and Engineering, Hunan University, Changsha 410082, China.
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Li
authors.affiliation: State Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083, PR China. Electronic address: y-hailin@csu.edu.cn.
authors.forename: Hailin
authors.initials: H
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083, PR China. Electronic address: jianming@csu.edu.cn.
authors.forename: Jianming
authors.initials: J
authors.lastname: Ruan
mesh_terms: D000497:Alloys / Q000737:chemistry / Q000494:pharmacology; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D006801:Humans; D008422:Materials Testing; D009556:Niobium / Q000737:chemistry / Q000494:pharmacology; D010006:Osteoblasts / Q000166:cytology / Q000378:metabolism*; D013635:Tantalum / Q000737:chemistry / Q000494:pharmacology; D014025:Titanium / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; D009556:Niobium; D013635:Tantalum; D014025:Titanium
keywords: Biocompatibility; Mechanical properties; Nb-Ti-Ta alloys; Powder metallurgy