title: Decreased response inhibition to sad faces during explicit and implicit tasks in females with depression: Evidence from an event-related potential study.
abstract: The present study aimed to investigate neural substrates of response inhibition to sad faces across explicit and implicit tasks in depressed female patients. Event-related potentials were obtained while participants performed modified explicit and implicit emotional go/no-go tasks. Compared to controls, depressed patients showed decreased discrimination accuracy and amplitudes of original and nogo-go difference waves at the P3 interval in response inhibition to sad faces during explicit and implicit tasks. P3 difference wave were positively correlated with discrimination accuracy and were independent of clinical assessment. The activation of right dorsal prefrontal cortex was larger for the implicit than for the explicit task in sad condition in health controls, but was similar for the two tasks in depressed patients. The present study indicated that selectively impairment in response inhibition to sad faces in depressed female patients occurred at the behavior inhibition stage across implicit and explicit tasks and may be a trait-like marker of depression. Longitudinal studies are required to determine whether decreased response inhibition to sad faces increases the risk for future depressive episodes so that appropriate treatment can be administered to patients.
authors.affiliation: Laboratory of Cognitive Neuropsychology, Department of Medical Psychology, Anhui Medical University, Hefei, China; Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China; Collaborative Innovation Centre of Neuropsychiatric Disorders and Mental Health, Anhui Province, China.
authors.forename: Fengqiong
authors.initials: F
authors.lastname: Yu
authors.affiliation: Anhui Mental Health Center, Hefei, China.
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Laboratory of Cognitive Neuropsychology, Department of Medical Psychology, Anhui Medical University, Hefei, China; Collaborative Innovation Centre of Neuropsychiatric Disorders and Mental Health, Anhui Province, China.
authors.forename: Wu
authors.initials: W
authors.lastname: Qing
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China; Collaborative Innovation Centre of Neuropsychiatric Disorders and Mental Health, Anhui Province, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Li
authors.affiliation: Laboratory of Cognitive Neuropsychology, Department of Medical Psychology, Anhui Medical University, Hefei, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: Laboratory of Cognitive Neuropsychology, Department of Medical Psychology, Anhui Medical University, Hefei, China; Collaborative Innovation Centre of Neuropsychiatric Disorders and Mental Health, Anhui Province, China.
authors.forename: Xingui
authors.initials: X
authors.lastname: Chen
authors.affiliation: Laboratory of Cognitive Neuropsychology, Department of Medical Psychology, Anhui Medical University, Hefei, China; Collaborative Innovation Centre of Neuropsychiatric Disorders and Mental Health, Anhui Province, China.
authors.forename: Gongjun
authors.initials: G
authors.lastname: Ji
authors.affiliation: Collaborative Innovation Centre of Neuropsychiatric Disorders and Mental Health, Anhui Province, China; Anhui Mental Health Center, Hefei, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Dong
authors.affiliation: Institute of Social and affective Neuroscience, Shenzhen University, Shenzhen, China.
authors.forename: Yuejia
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Laboratory of Cognitive Neuropsychology, Department of Medical Psychology, Anhui Medical University, Hefei, China; Collaborative Innovation Centre of Neuropsychiatric Disorders and Mental Health, Anhui Province, China. Electronic address: zhuchunyan@163.com.
authors.forename: Chunyan
authors.initials: C
authors.lastname: Zhu
authors.affiliation: Laboratory of Cognitive Neuropsychology, Department of Medical Psychology, Anhui Medical University, Hefei, China; Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China; Collaborative Innovation Centre of Neuropsychiatric Disorders and Mental Health, Anhui Province, China. Electronic address: wangkai1964@126.com.
authors.forename: Kai
authors.initials: K
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D003863:Depression / Q000503:physiopathology*; D003866:Depressive Disorder / Q000523:psychology; D004644:Emotions / Q000502:physiology*; D005071:Evoked Potentials / Q000502:physiology*; D000066499:Facial Recognition / Q000502:physiology*; D005260:Female; D006801:Humans; D007266:Inhibition, Psychological; D008137:Longitudinal Studies; D008875:Middle Aged; D055815:Young Adult
keywords: Depression; Emotion; Explicit; Implicit; P3; Response inhibition