title: Association of methylenetetrahydrofolate reductase gene-gene interaction and haplotype with susceptibility to acute lymphoblastic leukemia in Chinese children.
abstract: The aim of this study was to investigate the association of methylenetetrahydrofolate reductase (MTHFR) gene polymorphism and additional gene-gene interaction with acute lymphoblastic leukemia (ALL) risk. Logistic regression was performed to investigate the association between two single nucleotide polymorphisms (SNPs) within MTHFR gene and ALL risk and additional gene-gene interaction between rs1801133 and rs1801131. The minor allele of rs1801133 and rs1801131 is associated with decreased ALL risk, OR (95% CI) were 0.61 (0.38-0.89), and 0.68 (0.50-0.96), respectively. We also found a significantly interaction between the two SNPs, participants with rs1801133 - CT or TT and rs1801131 - AC or CC genotype have the lowest ALL risk, compared with participants with rs1801133 - CC and rs1801131 - AA genotype, OR (95% CI) was 0.32 (0.12-0.63). We did not find any haplotype between the rs1801133 and rs1801131 associated with ALL risk. rs1801133 and rs1801131 within MTHFR gene and their interaction were both associated with ALL risk in Chinese children.
authors.affiliation: a Department of Hematology , Tumor Hospital of Gansu Province , Lanzhou , Gansu , China.
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Xia
authors.affiliation: a Department of Hematology , Tumor Hospital of Gansu Province , Lanzhou , Gansu , China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Duan
authors.affiliation: a Department of Hematology , Tumor Hospital of Gansu Province , Lanzhou , Gansu , China.
authors.forename: Jie
authors.initials: J
authors.lastname: Cui
authors.affiliation: a Department of Hematology , Tumor Hospital of Gansu Province , Lanzhou , Gansu , China.
authors.forename: Junfeng
authors.initials: J
authors.lastname: Jiang
authors.affiliation: a Department of Hematology , Tumor Hospital of Gansu Province , Lanzhou , Gansu , China.
authors.forename: Li
authors.initials: L
authors.lastname: Lin
authors.affiliation: a Department of Hematology , Tumor Hospital of Gansu Province , Lanzhou , Gansu , China.
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Peng
authors.affiliation: a Department of Hematology , Tumor Hospital of Gansu Province , Lanzhou , Gansu , China.
authors.forename: YuHong
authors.initials: Y
authors.lastname: Wang
authors.affiliation: a Department of Hematology , Tumor Hospital of Gansu Province , Lanzhou , Gansu , China.
authors.forename: Bingtao
authors.initials: B
authors.lastname: Guo
authors.affiliation: a Department of Hematology , Tumor Hospital of Gansu Province , Lanzhou , Gansu , China.
authors.forename: Shouhai
authors.initials: S
authors.lastname: Liu
authors.affiliation: b Department of Pharmacy , Tumor Hospital of Gansu Province , Lanzhou , Gansu , China.
authors.forename: Xudong
authors.initials: X
authors.lastname: Lei
mesh_terms: D000293:Adolescent; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002681:China; D004843:Epistasis, Genetic; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007223:Infant; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*
chemical_list: D042965:Methylenetetrahydrofolate Reductase (NADPH2)
keywords: Acute lymphoblastic leukemia; MTHFR gene; SNP; haplotype; interaction