title: Squamous Cell Carcinoma Arising in Background of Mature Cystic Teratoma.
abstract: Mature cystic teratoma of ovary is a common benign adnexal tumor in females. Malignant transformation in a mature cystic teratoma of the ovary occurs in only 1 - 2% of cases. Most common malignant transformation is squamous cell carcinoma (70-80% of cases), occurring mostly in postmenopausal women with large sized cysts. Here, we report a case of 46-year lady who presented with pain in lower abdomen. Ultrasound and CT scan revealed complex adnexal mass measuring 16x9 cm. Size and older age of the patients should be regarded as important predictors of malignant transformation in mature cystic teratoma. Adequate sampling followed by histopathological examination has important role in diagnosis of such rare tumor.
authors.affiliation: Department of Histopathology, Armed Forces Institute of Pathology (AFIP), Rawalpindi.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Zubair
authors.affiliation: Department of Histopathology, Armed Forces Institute of Pathology (AFIP), Rawalpindi.
authors.forename: Shoaib Naiyar
authors.initials: SN
authors.lastname: Hashmi
authors.affiliation: Department of Histopathology, Armed Forces Institute of Pathology (AFIP), Rawalpindi.
authors.forename: Saeed
authors.initials: S
authors.lastname: Afzal
authors.affiliation: Department of Histopathology, Armed Forces Institute of Pathology (AFIP), Rawalpindi.
authors.forename: Iqbal
authors.initials: I
authors.lastname: Muhammad
authors.affiliation: Department of Histopathology, Armed Forces Institute of Pathology (AFIP), Rawalpindi.
authors.forename: Hafeez
authors.initials: H
authors.lastname: Ud Din
authors.affiliation: Department of Histopathology, Armed Forces Institute of Pathology (AFIP), Rawalpindi.
authors.forename: Syed Naeem Raza
authors.initials: SN
authors.lastname: Hamdani
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000601:surgery; D002471:Cell Transformation, Neoplastic; D003884:Dermoid Cyst / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000473:pathology* / Q000601:surgery; D010052:Ovariectomy; D011379:Prognosis; D058994:Salpingectomy; D013724:Teratoma / Q000473:pathology*; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor