title: Tumor lysis syndrome in solid tumors: Clinical characteristics and prognosis.
abstract: OBJECTIVE
  Tumour lysis syndrome (TLS) is an uncommon complication in solid tumors following treatment initiation, and its spontaneous development (STLS) is exceptional. In this study, we analyse the main clinical and prognostic features of a case series with TLS and STLS.
  
  
  METHODS
  Observational retrospective study in which we included all patients with solid tumours diagnosed with TLS and STLS over a period of 16 years, according to Cairo-Bishop criteria.
  
  
  RESULTS
  Nineteen patients were included in the study (mean age 63±16 years): 10 patients (53%) with TLS, and 9 (47%) STLS. The primary tumour in 8 cases (42%) was lung cancer. All patients had severe renal impairment at the time of diagnosis along with hyperuricemia (16±6mg/dl) and hyperkalemia (6±0.9mmol/l). Despite treatment with intravenous fluids, urinary alkalinisation and rasburicase, 3 patients (16%) required dialysis, and 12 (63%) died during the follow-up period.
  
  
  CONCLUSIONS
  The development of TLS in solid tumors is associated with increased mortality and therefore, a high index of suspicion is essential for early diagnosis and treatment initiation.
authors.affiliation: Servicio de Nefrología, Hospital Universitario Ramón y Cajal, Madrid, España. Electronic address: fcaravacaf@gmail.com.
authors.forename: Fernando
authors.initials: F
authors.lastname: Caravaca-Fontán
authors.affiliation: Servicio de Oncología Médica, Hospital Universitario Ramón y Cajal, Madrid, España.
authors.forename: Olga
authors.initials: O
authors.lastname: Martínez-Sáez
authors.affiliation: Servicio de Nefrología, Hospital Universitario Ramón y Cajal, Madrid, España.
authors.forename: Saúl
authors.initials: S
authors.lastname: Pampa-Saico
authors.affiliation: Servicio de Oncología Médica, Hospital Universitario Ramón y Cajal, Madrid, España.
authors.forename: Maria Eugenia
authors.initials: ME
authors.lastname: Olmedo
authors.affiliation: Servicio de Nefrología, Hospital Universitario Ramón y Cajal, Madrid, España.
authors.forename: Antonio
authors.initials: A
authors.lastname: Gomis
authors.affiliation: Servicio de Oncología Médica, Hospital Universitario Ramón y Cajal, Madrid, España.
authors.forename: Pilar
authors.initials: P
authors.lastname: Garrido
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D015275:Tumor Lysis Syndrome / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy
keywords: Acute renal failure; Fracaso renal agudo; Solid tumours; Síndrome lisis tumoral; Tumores sólidos; Tumour lysis syndrome