title: Malignant changes developing from odontogenic cysts: A systematic review.
abstract: The aim of this study was to systematically review scientific literature in orderto describe the characteristics and prognosis of malignant entities developing from odontogenic cysts. A search in Pubmed (MEDLINE) and Cochrane databases was conducted. The inclusion criteria were articles published in English related to the malignisation of odontogenic cysts in humans. The exclusion criteria were articles that do not specify the type of odontogenic cyst, malignisation of parakeratinised keratocysts, the presence of an ameloblastic carcinoma and metastasis from distant primary tumours. The selected articles were classified according to Strength of Recommendation Taxonomy criteria. Statistical analysis of the data was carried out using statistical package software SPSS version 22.0. From the 1,237 articles initially obtained, the authors included 3 case series and 45 case reports in the end. Descriptive analysis showed that men have a disposition for malignisation from odontogenic cysts and they frequently appear at the posterior mandible, with pain and swelling being the most frequent signs and symptoms. Follicular cysts were the entities that underwent the most malignant changes with well differentiated squamous cell carcinomas being the most prevalent type of malignancy. The real prognosis of this malignancy is not known because of the heterogeneity of available studies.Key words:Odontogenic cysts, squamous cell carcinoma, neoplastic cell transformation, oral cancer.
authors.affiliation: DDS. Fellow of the Master's Degree Program in Oral Surgery (EHFRE International University/FUCSO).
authors.forename: Jordi
authors.initials: J
authors.lastname: Borrás-Ferreres
authors.affiliation: DDS. Fellow of the Master of Oral Surgery and Orofacial Implantology. School of Dentistry, University of Barcelona, Spain.
authors.forename: Alba
authors.initials: A
authors.lastname: Sánchez-Torres
authors.affiliation: MD, DDS, MS, PhD, EBOS. Chairman and Professor of the Oral and Maxillofacial Surgery Department, School of Dentistry, University of Barcelona. Director of Master's Degree Program in Oral Surgery and Implantology (EHFRE International University/FUCSO). Coordinator/Researcher of the IDIBELL Institute. Head of Oral and Maxillofacial Surgery and Implantology Department of the Teknon Medical Centre, Barcelona, Spain.
authors.forename: Cosme
authors.initials: C
authors.lastname: Gay-Escoda