title: Vaccination for Mycobacterium tuberculosis infection: reprogramming CD4 T-cell homing into the lung.
abstract: Development of effective tuberculosis vaccines is hampered by insufficient understanding of protective immunity. Here, Woodworth et al.1show secondary effector CD4 T cells generated after Mtb challenge of H56/CAF01 vaccinated mice display superior lung homing compared with primary effectors. Vaccination generates large populations of parenchymal lung effector cells by inducing CXCR3+KLRG1-cells that continuously migrate from lymph nodes to lung, and limiting the generation of non-protective CX3CR1+KLRG1+intravascular effectors, providing insight vaccine-mediated protection against tuberculosis.
authors.affiliation: T lymphocyte Biology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: D L
authors.initials: DL
authors.lastname: Barber
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D008168:Lung / Q000276:immunology; D051379:Mice; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D032581:Tuberculosis Vaccines; D014611:Vaccination; D022223:Vaccines, Subunit
chemical_list: D032581:Tuberculosis Vaccines; D022223:Vaccines, Subunit