title: Interleukin 16 and CCL17/thymus and activation-regulated chemokine in patients with aspirin-exacerbated respiratory disease.
abstract: BACKGROUND
  Interleukin (IL) 16 and thymus and activation-regulated cytokine (TARC) are chemoattractant cytokines for eosinophils and TH2 cells. Differential levels of these components in aspirin-exacerbated respiratory disease (AERD) and allergic rhinitis with asthma (ARwA) may be related to a different inflammatory response in both asthma phenotypes.
  
  
  OBJECTIVE
  To assess the nasal lavage immunoreactivity of IL-16 and TARC cytokines.
  
  
  METHODS
  We used multienzyme-linked immunosorbent assays to detect IL-5, IL-13, IL-16, IL-33, I-309/CCL1, TARC/CCL17, monocyte-derived chemokine/CCL22, periostin, and eosinophil cationic protein levels in nasal lavages from patients with AERD and patients with ARwA.
  
  
  RESULTS
  The IL-13, IL-16, TARC, and periostin levels were significantly higher in patients with AERD compared with those of patients with ARwA. Correlation analysis of mediator levels in AERD revealed a possible role of IL-16 and TARC in eosinophil recruitment and activation.
  
  
  CONCLUSIONS
  IL-16, TARC, and periostin distinguish between patients with AERD and those with ARwA. These mediators, taken together rather than individually, may comprise good specific nasal markers in patients with AERD. The effects of IL-16 and TARC on TH1, TH2, and T-regulatory cell functions in AERD cannot be disregarded.
authors.affiliation: Departamento de Inmunogenética y Alergia, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico.
authors.forename: Luis Manuel
authors.initials: LM
authors.lastname: Teran
authors.affiliation: Departamento de Inmunogenética y Alergia, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico.
authors.forename: Fernando
authors.initials: F
authors.lastname: Ramirez-Jimenez
authors.affiliation: Facultad de Ciencias, Universidad Nacional Autónoma de México, Mexico City, Mexico.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Soid-Raggi
authors.affiliation: Departamento de Inmunogenética y Alergia, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico. Electronic address: velazquez_juan@outlook.com.
authors.forename: Juan Raymundo
authors.initials: JR
authors.lastname: Velazquez
mesh_terms: D000328:Adult; D001241:Aspirin / Q000009:adverse effects*; D015415:Biomarkers; D054414:Chemokine CCL17 / Q000378:metabolism*; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism*; D004804:Eosinophils / Q000276:immunology / Q000378:metabolism; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology; D019410:Interleukin-16 / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D017817:Nasal Lavage Fluid / Q000276:immunology; D010641:Phenotype; D012129:Respiratory Function Tests; D012130:Respiratory Hypersensitivity / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism*; D012882:Skin Tests; D018418:Th2 Cells / Q000276:immunology / Q000378:metabolism; D055815:Young Adult
chemical_list: D015415:Biomarkers; D054414:Chemokine CCL17; D019410:Interleukin-16; D007073:Immunoglobulin E; D001241:Aspirin