title: Hepitopes: A live interactive database of HLA class I epitopes in hepatitis B virus.
abstract: Increased clinical and scientific scrutiny is being applied to hepatitis B virus (HBV), with focus on the development of new therapeutic approaches, ultimately aiming for cure. Defining the optimum natural CD8+ T cell immune responses that arise in HBV, mediated by HLA class I epitope presentation, may help to inform novel immunotherapeutic strategies. Therefore, we have set out to develop a comprehensive database of these epitopes in HBV, coined 'Hepitopes'. This undertaking has its foundations in a systematic literature review to identify the sites and sequences of all published class I epitopes in HBV. We also collected information regarding the methods used to define each epitope, and any reported associations between an immune response to this epitope and disease outcome. The results of this search have been collated into a new open-access interactive database that is available at http://www.expmedndm.ox.ac.uk/hepitopes. Over time, we will continue to refine and update this resource, as well as inviting contributions from others in the field to support its development. This unique new database is an important foundation for ongoing investigations into the nature and impact of the CD8+ T cell response to HBV.
authors.affiliation: Department of Infectious Diseases and Microbiology, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK.
authors.forename: Sheila
authors.initials: S
authors.lastname: Lumley
authors.affiliation: IT Services, University of Oxford, Oxford, UK.
authors.forename: Howard
authors.initials: H
authors.lastname: Noble
authors.affiliation: IT Services, University of Oxford, Oxford, UK.
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Hadley
authors.affiliation: Bodleian Health Care Libraries, University of Oxford, John Radcliffe Hospital, Oxford, UK.
authors.forename: Liz
authors.initials: L
authors.lastname: Callow
authors.affiliation: Department of Paediatrics, University of Oxford, Oxford, UK.
authors.forename: Amna
authors.initials: A
authors.lastname: Malik
authors.affiliation: University of Oxford Medical School, John Radcliffe Hospital, Oxford, UK.
authors.forename: Yi Yi
authors.initials: YY
authors.lastname: Chua
authors.affiliation: University of Oxford Medical School, John Radcliffe Hospital, Oxford, UK.
authors.forename: Owen J
authors.initials: OJ
authors.lastname: Duffey
authors.affiliation: University of Oxford Medical School, John Radcliffe Hospital, Oxford, UK.
authors.forename: Natalia
authors.initials: N
authors.lastname: Grolmusova
authors.affiliation: University of Oxford Medical School, John Radcliffe Hospital, Oxford, UK.
authors.forename: Arvind
authors.initials: A
authors.lastname: Kumar
authors.affiliation: University of Oxford Medical School, John Radcliffe Hospital, Oxford, UK.
authors.forename: Samuel
authors.initials: S
authors.lastname: Ravenscroft
authors.affiliation: University of Oxford Medical School, John Radcliffe Hospital, Oxford, UK.
authors.forename: Jonathan I
authors.initials: JI
authors.lastname: Spencer
authors.affiliation: Department of Medicine II, University Hospital Freiburg, Freiburg, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Neumann-Haefelin
authors.affiliation: Department of Medicine II, University Hospital Freiburg, Freiburg, Germany.
authors.forename: Robert
authors.initials: R
authors.lastname: Thimme
authors.affiliation: Department of Infectious Diseases and Microbiology, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK.
authors.forename: Monique
authors.initials: M
authors.lastname: Andersson
authors.affiliation: Department of Infectious Diseases and Microbiology, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK.|Nuffield Department of Experimental Medicine, University of Oxford, Oxford, UK.|NIHR Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK.
authors.forename: Paul
authors.identifier: 0000-0003-4307-9161
authors.initials: P
authors.lastname: Klenerman
authors.affiliation: Nuffield Department of Experimental Medicine, University of Oxford, Oxford, UK.|NIHR Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK.
authors.forename: Eleanor
authors.initials: E
authors.lastname: Barnes
authors.affiliation: Department of Infectious Diseases and Microbiology, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK.|Nuffield Department of Experimental Medicine, University of Oxford, Oxford, UK.
authors.forename: Philippa C
authors.initials: PC
authors.lastname: Matthews
keywords: CD8+ T cell; HBV; HLA class I; Hepatitis B Virus; database; epitope