title: Preparation and characterization of chitosan physical hydrogels with enhanced mechanical and antibacterial properties.
abstract: The chitosan physical hydrogels formed under gaseous ammonia atmospheres usually have poor mechanical properties and low antibacterial activities, which limit its application as biomaterials. In the current study, CTS-Ag+/NH3physical hydrogels with great comprehensive properties were prepared by the gelation of chitosan in the presence of AgNO3under a gaseous ammonia atmosphere. Compared with the previously reported hydrogels made with chitosan and AgNO3, the CTS-Ag+/NH3hydrogels were more homogeneous and transparent. In addition, the AgNO3content in the hydrogels was decreased to 0.064-0.424wt.%. The formation mechanism and the influence of reaction conditions on the structures and properties of CTS-Ag+/NH3physical hydrogels were characterized by FT-IR, SEM, XPS, XRD and rheological measurement. Tensile testing suggested that CTS-Ag+/NH3physical hydrogels had a higher tensile strength than the CTS/NH3hydrogel. Moreover, the CTS-Ag+/NH3physical hydrogels showed excellent antibacterial activities against both gram positive and negative bacteria.
authors.affiliation: School of Materials Science and Engineering, Beijing Institute of Technology, Beijing 100081, PR China.
authors.forename: Peng
authors.initials: P
authors.lastname: Li
authors.affiliation: School of Materials Science and Engineering, Beijing Institute of Technology, Beijing 100081, PR China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhao
authors.affiliation: School of Materials Science and Engineering, Beijing Institute of Technology, Beijing 100081, PR China. Electronic address: cylsy@163.com.
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Clinical Laboratory, Pudong New Area People's Hospital, Shanghai 201200, PR China.
authors.forename: Bin
authors.initials: B
authors.lastname: Cheng
authors.affiliation: School of Materials Science and Engineering, Beijing Institute of Technology, Beijing 100081, PR China.
authors.forename: Ziyang
authors.initials: Z
authors.lastname: Yu
authors.affiliation: School of Materials Science and Engineering, Beijing Institute of Technology, Beijing 100081, PR China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: School of Materials Science and Engineering, Beijing Institute of Technology, Beijing 100081, PR China.
authors.forename: Xiaoting
authors.initials: X
authors.lastname: Yan
authors.affiliation: School of Materials Science and Engineering, Beijing Institute of Technology, Beijing 100081, PR China.
authors.forename: Zongrui
authors.initials: Z
authors.lastname: Tong
authors.affiliation: School of Materials Science and Engineering, Beijing Institute of Technology, Beijing 100081, PR China.
authors.forename: Shaohua
authors.initials: S
authors.lastname: Jin
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry*; D048271:Chitosan / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D020100:Hydrogels; D048271:Chitosan
keywords: Antibacterial activity; CTS-Ag(+)/NH(3) physical hydrogels; Chitosan; Mechanical property