title: Sesquiterpenoids from the twigs and leaves of Fokienia hodginsii.
abstract: A rare carotane-type sesquiterpenoid, forkienin A (1), a new eudesmane-type sesquiterpenoid, forkienin B (2), and a new natural eudesmane-type sesquiterpenoid, forkienin C (3), were isolated from the twigs and leaves of Fokienia hodginsii, along with eight known sesquiterpenoids. The structures of the new compounds were elucidated on the basis of their spectroscopic analysis, including 1D and 2D NMR methods. All compounds were evaluated for cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, and SW480 cell lines.
authors.affiliation: a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
authors.forename: Xing-De
authors.initials: XD
authors.lastname: Wu
authors.affiliation: a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.|b Biomedical Engineering Research Center , Kunming Medical University , Kunming 650500 , China.
authors.forename: Wen-Wen
authors.initials: WW
authors.lastname: Zhong
authors.affiliation: c School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products , Kunming Medical University , Kunming 650500 , China.
authors.forename: Lin-Fen
authors.initials: LF
authors.lastname: Ding
authors.affiliation: c School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products , Kunming Medical University , Kunming 650500 , China.
authors.forename: Wen-Chao
authors.initials: WC
authors.lastname: Tu
authors.affiliation: c School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products , Kunming Medical University , Kunming 650500 , China.
authors.forename: Hui
authors.initials: H
authors.lastname: Yang
authors.affiliation: a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
authors.forename: Xun
authors.initials: X
authors.lastname: Gong
authors.affiliation: a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
authors.forename: Li-Yan
authors.initials: LY
authors.lastname: Peng
authors.affiliation: a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: d Institute of Alpine Economic Plant , Yunnan Academy of Agricutural Science , Lijiang 674100 , China.
authors.forename: Zhong-Zhi
authors.initials: ZZ
authors.lastname: Xu
authors.affiliation: a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
authors.forename: Qin-Shi
authors.initials: QS
authors.lastname: Zhao
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D018922:HL-60 Cells; D006801:Humans; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry*; D018547:Plant Stems / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045787:Sesquiterpenes, Eudesmane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D012717:Sesquiterpenes; D045787:Sesquiterpenes, Eudesmane; C000621561:forkienin A; C000621562:forkienin B; C015872:eudesmane
keywords: Cupressaceae; Fokienia hodginsii; carotane-type sesquiterpenoid; cytotoxic activity; eudesmane-type sesquiterpenoid; sesquiterpenoids