title: Neurocognitive Function Surrounding the Resection of Frontal WHO Grade I Meningiomas: A Prospective Matched-Control Study.
abstract: OBJECTIVE
  Patients with intracranial meningiomas can experience neurocognitive dysfunctions in specific cognitive domains depending on tumor location and size. The literature regarding cognitive function surrounding the resection of frontal meningiomas is sparse.
  
  
  METHODS
  We performed a prospective matched-control study to investigate the cognitive performance of frontal meningioma patients undergoing resection. The neurocognitive status 1 week and 2 months after resection was compared with the preoperative status and matched-controls. Matching was performed for age, sex, handedness, education, and profession. An extensive test battery was used to assess perceptual speed, executive function, visual-spatial and verbal working memory, short- and long-term memory, verbal fluency, fluid intelligence, anxiety, and depression.
  
  
  RESULTS
  Twelve patients with frontal World Health Organization grade I meningioma and 12 matched-controls underwent cognitive testing. Macroscopically, complete removal was achieved in all cases. Comparison of patients and controls revealed significant cognitive impairments in perceptual speed, executive function, short-term memory, and verbal fluency preoperatively and postoperatively. At 2 months' follow-up, perceptual speed and verbal fluency were still significantly impaired, whereas executive function and short-term memory were equal to that in the control group. None of the patients experienced cognitive deterioration after surgical therapy.
  
  
  CONCLUSIONS
  Patients with frontal meningiomas display preoperative and postoperative deficits in perceptual speed, executive function, short-term memory, and verbal fluency. The risk for cognitive deterioration owing to surgical resection is low. Within the first two months after surgery, executive function and short-term memory appear to recover.
authors.affiliation: Department of Neurosurgery, Saarland University Medical Center, Saarland University Faculty of Medicine, Homburg (Saar), Germany. Electronic address: hendrix.philipp@gmail.com.
authors.forename: Philipp
authors.initials: P
authors.lastname: Hendrix
authors.affiliation: Department of Neurosurgery, Saarland University Medical Center, Saarland University Faculty of Medicine, Homburg (Saar), Germany.
authors.forename: Elisa
authors.initials: E
authors.lastname: Hans
authors.affiliation: Neurosurgical Service, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA; Department of Neurosurgery, Geisinger Health System, Danville, Pennsylvania, USA.
authors.forename: Christoph J
authors.initials: CJ
authors.lastname: Griessenauer
authors.affiliation: Department of Neuroradiology, Saarland University Medical Center, Saarland University Faculty of Medicine, Homburg (Saar), Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Simgen
authors.affiliation: Department of Neurosurgery, Saarland University Medical Center, Saarland University Faculty of Medicine, Homburg (Saar), Germany.
authors.forename: Joachim
authors.initials: J
authors.lastname: Oertel
authors.affiliation: Department of Psychology, Goethe University, Frankfurt, Germany.
authors.forename: Julia
authors.initials: J
authors.lastname: Karbach
mesh_terms: D000368:Aged; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery; D016022:Case-Control Studies; D003071:Cognition; D003072:Cognition Disorders / Q000000981:diagnostic imaging* / Q000209:etiology / Q000523:psychology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery; D008579:Meningioma / Q000000981:diagnostic imaging* / Q000601:surgery; D008875:Middle Aged; D060787:Neoplasm Grading / Q000379:methods; D009483:Neuropsychological Tests; D019635:Neurosurgical Procedures / Q000009:adverse effects*; D011183:Postoperative Complications / Q000000981:diagnostic imaging* / Q000209:etiology / Q000523:psychology; D011446:Prospective Studies
keywords: Cognition; Frontal; Meningioma; Neurocognitive assessment