title: Biomimetic synthesis of sericin and silica hybrid colloidosomes for stimuli-responsive anti-cancer drug delivery systems.
abstract: Colloidosomes are becoming popular due to their significant flexibility with respect to microcapsule functionality. This study reports a facile approach for synthesizing silica colloidosomes by using sericin microcapsule as the matrix in an environment-friendly method. The silica colloid arrangement on the sericin microcapsules are orchestrated by altering the reaction parameters. Doxorubicin (DOX), used as a hydrophilic anti-cancer drug model, is encapsulated into the colloidosomes in a mild aqueous solution and becomes stimuli-responsive to different external environments, including pH values, protease, and ionic strength are also observed. Colloidosomes with sub-monolayers, close-packed monolayers, and close-packed multi-layered SiO2colloid shells can be fabricated under the optimized reaction conditions. A flexible DOX release from colloidosomes can be obtained via modulating the SiO2colloid layer arrangement and thickness. The close-packed and multi-layered SiO2colloid shells can best protect the colloidosomes and delay the rapid cargo release. MG-63 cells are killed when doxorubicin is released from the microcapsules due to degradation in the microenvironment of cancer cells. The drug release period is prolonged as SiO2shell thickness and integrity increase. This work suggests that the hybrid colloidosomes can be effective in a bioactive molecule delivery system.
authors.affiliation: The Key Laboratory of Advanced Textile Materials and Manufacturing Technology of Ministry of Education, National Engineering Lab for Textile Fiber Materials and Processing Technology (Zhejiang), College of Materials and Textiles, Zhejiang Sci-Tech University, Hangzhou 310018, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Yang
authors.affiliation: The Key Laboratory of Advanced Textile Materials and Manufacturing Technology of Ministry of Education, National Engineering Lab for Textile Fiber Materials and Processing Technology (Zhejiang), College of Materials and Textiles, Zhejiang Sci-Tech University, Hangzhou 310018, China. Electronic address: caiyr@zstu.edu.cn.
authors.forename: Yurong
authors.initials: Y
authors.lastname: Cai
authors.affiliation: The Key Laboratory of Advanced Textile Materials and Manufacturing Technology of Ministry of Education, National Engineering Lab for Textile Fiber Materials and Processing Technology (Zhejiang), College of Materials and Textiles, Zhejiang Sci-Tech University, Hangzhou 310018, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Sun
authors.affiliation: The Key Laboratory of Advanced Textile Materials and Manufacturing Technology of Ministry of Education, National Engineering Lab for Textile Fiber Materials and Processing Technology (Zhejiang), College of Materials and Textiles, Zhejiang Sci-Tech University, Hangzhou 310018, China.
authors.forename: Ruijing
authors.initials: R
authors.lastname: Li
authors.affiliation: The Key Laboratory of Advanced Textile Materials and Manufacturing Technology of Ministry of Education, National Engineering Lab for Textile Fiber Materials and Processing Technology (Zhejiang), College of Materials and Textiles, Zhejiang Sci-Tech University, Hangzhou 310018, China.
authors.forename: Wenhua
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Biotechnology, Indian Institute of Technology (IIT), Kharagpur, West Bengal 721302, India; 3Bs Research Group, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, University of Minho, AvePark, 4805-017 Barco, Taipas, Guimaraes, Portugal.
authors.forename: Subhas C
authors.initials: SC
authors.lastname: Kundu
authors.affiliation: College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou 310018, China.
authors.forename: Xiangdong
authors.initials: X
authors.lastname: Kong
authors.affiliation: The Key Laboratory of Advanced Textile Materials and Manufacturing Technology of Ministry of Education, National Engineering Lab for Textile Fiber Materials and Processing Technology (Zhejiang), College of Materials and Textiles, Zhejiang Sci-Tech University, Hangzhou 310018, China. Electronic address: yaoj@zstu.edu.cn.
authors.forename: Juming
authors.initials: J
authors.lastname: Yao
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry*; D040761:Biomimetic Materials / Q000138:chemical synthesis* / Q000737:chemistry; D002214:Capsules; D045744:Cell Line, Tumor; D002470:Cell Survival; D003102:Colloids / Q000138:chemical synthesis* / Q000737:chemistry; D004317:Doxorubicin / Q000737:chemistry; D016503:Drug Delivery Systems; D065546:Drug Liberation; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007477:Ions; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D009336:Necrosis; D009994:Osmolar Concentration; D010316:Particle Size; D010447:Peptide Hydrolases / Q000737:chemistry; D047030:Sericins / Q000138:chemical synthesis* / Q000737:chemistry; D012822:Silicon Dioxide / Q000138:chemical synthesis* / Q000737:chemistry; D013696:Temperature
chemical_list: D000970:Antineoplastic Agents; D002214:Capsules; D003102:Colloids; D007477:Ions; D047030:Sericins; D012822:Silicon Dioxide; D004317:Doxorubicin; D010447:Peptide Hydrolases
keywords: Colloidosomes; Drug delivery; Sericin; Stimuli-responsive; Synthesis