title: Association between sleep duration and cardiac structure in youths at risk for metabolic syndrome.
abstract: The evidence for a link between sleep duration and cardiovascular risk is accumulating in youths, but no study has yet investigated the relationship between sleep duration and change of cardiac structure. In this study, we recruited 559 youths aged 14-28 years from the cohort of Beijing Child and Adolescent Metabolic Syndrome Study. Questionnaire, color Doppler echocardiography, oral glucose tolerance test and blood biomarkers analyses were performed. We found that sleep duration was negatively correlated with body mass index, waist circumstance, and HbA1c (all P < 0.05), but not with adiponectin and leptin. Meanwhile, participants with shorter sleep duration (≤7 h) had larger interventricular septal diastolic thickness, left ventricular (LV) end-diastolic diameter, LV posterior wall thickness, LV mass (LVM), and LV mass index (LVMI), compared to participants in 7-9 h/night or >9 h/night group. Findings remained significant after adjustment for the major confounding factors (P < 0.05). Multivariate regression modeling revealed that each additional hour of sleep was associated with smaller LVM (β: -3.483, P < 0.0001) and LVMI (β: -0.815, P < 0.0001). Our findings suggest that short sleep has a possible direct effect on cardiac remodeling, occurring already at young ages.
authors.affiliation: Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Feng
authors.affiliation: Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
authors.forename: Jihui
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Endocrinology, Key Laboratory of Endocrinology, National Health and Family Planning Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Junling
authors.initials: J
authors.lastname: Fu
authors.affiliation: Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
authors.forename: Heng
authors.initials: H
authors.lastname: Wu
authors.affiliation: Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
authors.forename: Yonghui
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Endocrinology, Key Laboratory of Endocrinology, National Health and Family Planning Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Lujiao
authors.initials: L
authors.lastname: Li
authors.affiliation: Epidemiology Department, Fielding School of Public Health, University of California Los Angeles, USA.
authors.forename: Yanglu
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Endocrinology, Key Laboratory of Endocrinology, National Health and Family Planning Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
authors.forename: Shan
authors.initials: S
authors.lastname: Gao
mesh_terms: D052242:Adiponectin / Q000097:blood; D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D005260:Female; D005500:Follow-Up Studies; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D020738:Leptin / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000473:pathology / Q000503:physiopathology; D012307:Risk Factors; D012890:Sleep; D055105:Waist Circumference
chemical_list: D052242:Adiponectin; D006442:Glycated Hemoglobin; D020738:Leptin; C499918:ADIPOQ protein, human; C517652:hemoglobin A1c protein, human