title: Extended Clearance Classification System (ECCS) informed approach for evaluating investigational drugs as substrates of drug transporters.
authors.affiliation: Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Groton, Connecticut, USA.
authors.forename: M V
authors.initials: MV
authors.lastname: Varma
authors.affiliation: Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Cambridge, Massachusetts, USA.
authors.forename: A F
authors.initials: AF
authors.lastname: El-Kattan
authors.affiliation: Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Groton, Connecticut, USA.
authors.forename: B
authors.initials: B
authors.lastname: Feng
authors.affiliation: Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Cambridge, Massachusetts, USA.
authors.forename: S J
authors.initials: SJ
authors.lastname: Steyn
authors.affiliation: Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Cambridge, Massachusetts, USA.
authors.forename: T S
authors.initials: TS
authors.lastname: Maurer
authors.affiliation: Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Cambridge, Massachusetts, USA.
authors.forename: D O
authors.initials: DO
authors.lastname: Scott
authors.affiliation: Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Groton, Connecticut, USA.
authors.forename: A D
authors.initials: AD
authors.lastname: Rodrigues
authors.affiliation: Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Groton, Connecticut, USA.
authors.forename: L M
authors.initials: LM
authors.lastname: Tremaine
mesh_terms: D001692:Biological Transport; D062126:Databases, Chemical; D055808:Drug Discovery; D004347:Drug Interactions / Q000502:physiology*; D004335:Drug and Narcotic Control / Q000379:methods; D064420:Drug-Related Side Effects and Adverse Reactions / Q000517:prevention & control; D015507:Drugs, Investigational / Q000145:classification / Q000493:pharmacokinetics; D006801:Humans; D008657:Metabolic Clearance Rate; D018570:Risk Assessment / Q000379:methods
chemical_list: D015507:Drugs, Investigational