title: Process-Oriented Review of Bacterial Quorum Quenching for Membrane Biofouling Mitigation in Membrane Bioreactors (MBRs).
abstract: Quorum Quenching (QQ) has been developed over the last few years to overcome practical issues related to membrane biofouling, which is currently the major difficulty thwarting the extensive development of membrane bioreactors (MBRs). QQ is the disruption of Quorum Sensing (QS), cell-to-cell communication enabling the bacteria to harmonize their behavior. The production of biofilm, which is recognized as a major part of the biocake formed on a membrane surface, and which leads to biofouling, has been found to be one of the bacterial behaviors controlled by QS. Since the enzymatic disruption of QS was reported to be efficient as a membrane biofouling mitigation technique in MBRs, the application of QQ to lab-scale MBRs has been the subject of much research using different approaches under different operating conditions. This paper gives an overview of the effectiveness of QQ in mitigating membrane biofouling in MBRs. It is based on the results of previous studies, using two microbial strains,Rhodococcussp. BH4 andPseudomonassp. 1A1. The effect of bacterial QQ on the physical phenomena of the MBR process is analyzed, adopting an original multi-scale approach. Finally, the potential influence of the MBR operating conditions on QQ effectiveness is discussed.
authors.affiliation: LISBP-Laboratoire d'Ingénierie des Systèmes Biologiques et des Procédés), CNRS-Centre National de la Recherche Scientifique), INRA-Institut National de la Recherche Agronomique), INSA-Institut National des Sciences Appliquées), Université de Toulouse, Toulouse 31077, France. bouayed@insa-toulouse.fr.
authors.forename: Naila
authors.initials: N
authors.lastname: Bouayed
authors.affiliation: LISBP-Laboratoire d'Ingénierie des Systèmes Biologiques et des Procédés), CNRS-Centre National de la Recherche Scientifique), INRA-Institut National de la Recherche Agronomique), INSA-Institut National des Sciences Appliquées), Université de Toulouse, Toulouse 31077, France. dietrich@insa-toulouse.fr.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Dietrich
authors.affiliation: LISBP-Laboratoire d'Ingénierie des Systèmes Biologiques et des Procédés), CNRS-Centre National de la Recherche Scientifique), INRA-Institut National de la Recherche Agronomique), INSA-Institut National des Sciences Appliquées), Université de Toulouse, Toulouse 31077, France. lafforgu@insa-toulouse.fr.
authors.forename: Christine
authors.initials: C
authors.lastname: Lafforgue
authors.affiliation: School of Chemical and Biological Engineering, Seoul National University, Seoul 08826, Korea. leech@snu.ac.kr.
authors.forename: Chung-Hak
authors.initials: CH
authors.lastname: Lee
authors.affiliation: LISBP-Laboratoire d'Ingénierie des Systèmes Biologiques et des Procédés), CNRS-Centre National de la Recherche Scientifique), INRA-Institut National de la Recherche Agronomique), INSA-Institut National des Sciences Appliquées), Université de Toulouse, Toulouse 31077, France. guigui@insa-toulouse.fr.
authors.forename: Christelle
authors.initials: C
authors.lastname: Guigui
keywords: Quorum Quenching; Quorum Sensing; acyl-homoserine lactones; acylase; biofilm; biofouling; extracellular polymeric substances (EPS); lactonase; membrane bioreactors