title: Successful Therapy of Severe Pseudomembranous Clostridium difficile Colitis Using a Combination of Fecal Microbiota Therapy and Fidaxomicin.
abstract: OBJECTIVE
  The aim of this work was to describe the use of a combination of fidaxomicin and fecal microbiota therapy (FMT) in Clostridium difficile infection (CDI).
  
  
  METHODS
  A 78-year-old female, who was admitted for surgery due to acute diverticulitis caused by postoperative complications and broad antibiotic therapy, developed CDI-induced colitis. Despite the introduction of metronidazole and vancomycin therapy, her clinical condition continued to deteriorate. She was transferred to the intensive care unit where FMT followed by fidaxomicin were performed because her C-reactive protein and leucocyte levels remained elevated. Further clinical improvement and the resolution of colitis was observed.
  
  
  CONCLUSIONS
  In this case, severe CDI colitis was successfully treated with the combination of FMT and fidaxomicin.
authors.affiliation: Department of Internal Medicine, Thuringia Clinic Saalfeld, Teaching Hospital of the University of Jena, Saalfeld, Germany.
authors.forename: Peter C
authors.initials: PC
authors.lastname: Konturek
authors.forename: Drilon
authors.initials: D
authors.lastname: Haziri
authors.forename: Harry
authors.initials: H
authors.lastname: Helfritzsch
authors.forename: Thomas
authors.initials: T
authors.lastname: Hess
authors.forename: Igor A
authors.initials: IA
authors.lastname: Harsch
mesh_terms: D000368:Aged; D000617:Aminoglycosides / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D016360:Clostridioides difficile; D003015:Clostridium Infections / Q000628:therapy*; D004761:Enterocolitis, Pseudomembranous / Q000628:therapy*; D000069467:Fecal Microbiota Transplantation / Q000379:methods*; D005260:Female; D000077732:Fidaxomicin; D006801:Humans
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000077732:Fidaxomicin