title: Sustained release gastroretentive tablet of metformin hydrochloride based on poly (acrylic acid)-grafted-gellan.
abstract: Development of a gastroretentive sustained release tablet of metformin based on poly (acrylic acid)-grafted-gellan (PAAc-g-GG) is the main purpose of this study. At first, PAAc-g-GG was synthesized by microwave-promoted free radical initiation method using cerric (IV) ammonium nitrate (CAN) as redox initiator and characterized by elemental analysis, FTIR, DSC-TGA,13C NMR, biodegradation and viscosity study. The synthetic parameters were optimized by 23full factorial design using Design Expert software. Acute oral toxicity and histological studies were also performed as per OECD guideline. Tablets were then prepared employing wet granulation method using PAAc-g-GG and evaluated for various physical characters, in vitro drug release, ex-vivo mucoadhesion and swelling. Compatibility between drug and excipients was checked by DSC and FTIR analysis. The F3 batch showed excellent mucoadhesion and sustained drug release over a period of 10h with dissolution similarity factor, f2=77.43. Kinetic modeling unveiled Case-1 Fickian diffusion based drug release mechanism.
authors.affiliation: Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India.
authors.forename: Debjani
authors.initials: D
authors.lastname: Sarkar
authors.affiliation: BCDA College of Pharmacy & Technology, 78, Jessore Road (S), Hridaypur, Kolkata 700127, India. Electronic address: nandi_gouranga@yahoo.co.in.
authors.forename: Gouranga
authors.initials: G
authors.lastname: Nandi
authors.affiliation: Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India.
authors.forename: Abhijit
authors.initials: A
authors.lastname: Changder
authors.affiliation: Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India.
authors.forename: Prasenjit
authors.initials: P
authors.lastname: Hudati
authors.affiliation: Bengal School of Technology, Sugandha, Delhi Road, Hooghly, West Bengal, 712102, India.
authors.forename: Sayani
authors.initials: S
authors.lastname: Sarkar
authors.affiliation: Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India.
authors.forename: Lakshmi Kanta
authors.initials: LK
authors.lastname: Ghosh
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000268:Adhesiveness; D000818:Animals; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D005260:Female; D005753:Gastric Mucosa / Q000737:chemistry / Q000378:metabolism*; D008687:Metformin / Q000737:chemistry* / Q000378:metabolism*; D051379:Mice; D008872:Microwaves; D011135:Polysaccharides, Bacterial / Q000737:chemistry*; D013607:Tablets; D014783:Viscosity
chemical_list: D000180:Acrylic Resins; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011135:Polysaccharides, Bacterial; D013607:Tablets; C006903:carbopol 940; C048288:gellan gum; D008687:Metformin
keywords: Mucoadhesive; Poly (acrylic acid)-grafted-gellan; Sustained release