title: Calcification score evaluation in patients listed for renal transplantation.
abstract: Based on native CT scans of the pelvic region using a standardized calcification score, evaluation of iliac vascular calcification was performed between 2008 and 2012 prior to listing for renal transplantation in 205 patients with chronic kidney disease. Vascular calcification showed a decrease from proximal to distal. The difference between the degree of calcification in the common iliac artery and in the external iliac artery was significant (P<.001). Risk factors for total iliac vascular calcification were age, smoking, sex, underlying renal disease, and diabetes. Multivariate analysis revealed age to be the most relevant risk factor (P<.001). The duration of hemodialysis correlated significantly with total iliac vascular calcification. As the introduction of the standardized surgical evaluation protocol, no transplantation has had to be broken off and no early graft loss due to calcification has occurred. Thus, careful scoring of vascular calcification prior to transplantation may be a valuable tool to support surgical decisions and to improve patient safety and outcome in increasingly older transplant recipients.
authors.affiliation: Division of Transplantation Surgery, Department of Surgery, Medical University of Graz, Graz, Austria.
authors.forename: Judith
authors.initials: J
authors.lastname: Kahn
authors.affiliation: Division of Transplantation Surgery, Department of Surgery, Medical University of Graz, Graz, Austria.
authors.forename: Leona Marleen
authors.initials: LM
authors.lastname: Ram
authors.affiliation: Core Facility Computational Bioanalytics, Center for Medical Research, Medical University of Graz, Graz, Austria.
authors.forename: Katharina
authors.initials: K
authors.lastname: Eberhard
authors.affiliation: Core Facility Computational Bioanalytics, Center for Medical Research, Medical University of Graz, Graz, Austria.
authors.forename: Andrea
authors.initials: A
authors.lastname: Groselj-Strele
authors.affiliation: Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
authors.forename: Barbara
authors.initials: B
authors.lastname: Obermayer-Pietsch
authors.affiliation: Division of Transplantation Surgery, Department of Surgery, Medical University of Graz, Graz, Austria.
authors.forename: Helmut
authors.initials: H
authors.lastname: Müller
mesh_terms: D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006801:Humans; D007083:Iliac Artery / Q000000981:diagnostic imaging*; D007676:Kidney Failure, Chronic / Q000601:surgery*; D007677:Kidney Function Tests; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D014057:Tomography, X-Ray Computed / Q000379:methods; D066027:Transplant Recipients; D061205:Vascular Calcification / Q000000981:diagnostic imaging*
keywords: calcification score; evaluation; renal transplantation