title: Biocompatible hyperbranched polyglycerol modified β-cyclodextrin derivatives for docetaxel delivery.
abstract: The development of biocompatible vector for hydrophobic drug delivery remains a longstanding issue in cancer therapy. We design and synthesis a drug delivery system based on HPG modified β-CD (β-CD-HPG) by conjugating HPG branches onto β-CD core and its structure was confirmed by NMR, FTIR, GPC and solubility. In vitro biocompatibility tests showed that HPG modification significantly improved red blood cells morphology alteration and hemolysis cause by β-CD and β-CD-HPG displayed cell safety apparently in a wide range of 0.01-1mg/mL. An anti-cancer drug, docetaxel, was effectively encapsulated into β-CD-HPG which was confirmed by DSC analysis. This copolymer could form nanoparticles with small size (<200nm) and exhibited better DTX loading capacity and controlled release kinetics without initial burst release behavior compared with β-CD. Furthermore, antitumor assay in vitro show that β-CD-HPG/DTX effectively inhibited proliferation of human breast adenocarcinoma cells. Therefore, β-CD-HPG/DTX exhibit great potential for cancer chemotherapy.
authors.affiliation: Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou, 510632, China.
authors.forename: Zejun
authors.initials: Z
authors.lastname: Xu
authors.affiliation: Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou, 510632, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou, 510632, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Hu
authors.affiliation: Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou, 510632, China.
authors.forename: Qiao
authors.initials: Q
authors.lastname: Tang
authors.affiliation: The School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia.
authors.forename: Jiake
authors.initials: J
authors.lastname: Xu
authors.affiliation: 3D Imaging and Bioengineering Laboratory, Department of Mechanical Engineering, Curtin University, Australia.
authors.forename: Jianping
authors.initials: J
authors.lastname: Wu
authors.affiliation: 3D Imaging and Bioengineering Laboratory, Department of Mechanical Engineering, Curtin University, Australia.
authors.forename: Thomas Brett
authors.initials: TB
authors.lastname: Kirk
authors.affiliation: Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou, 510632, China. Electronic address: tmadong@jnu.edu.cn.
authors.forename: Dong
authors.initials: D
authors.lastname: Ma
authors.affiliation: Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou, 510632, China. Electronic address: weixue_jnu@hotmail.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Xue
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D002460:Cell Line; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D000077143:Docetaxel; D004354:Drug Screening Assays, Antitumor; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D005990:Glycerol / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D011108:Polymers / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D043823:Taxoids / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D047392:beta-Cyclodextrins / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: D003692:Delayed-Action Preparations; D011108:Polymers; D043823:Taxoids; D047392:beta-Cyclodextrins; D000077143:Docetaxel; C043941:polyglycerol; D005990:Glycerol
keywords: Biocompatibility; Cancer therapy; Drug carrier; Hyperbranched polyglycerol (HPG); β-Cyclodextrin (β-CD)