title: Subclinical Disease Burden as Assessed by Whole-Body MRI in Subjects With Prediabetes, Subjects With Diabetes, and Normal Control Subjects From the General Population: The KORA-MRI Study.
abstract: Detailed pathophysiological manifestations of early disease in the context of prediabetes are poorly understood. This study aimed to evaluate the extent of early signs of metabolic and cardio-cerebrovascular complications affecting multiple organs in individuals with prediabetes. Subjects without a history of stroke, coronary artery disease, or peripheral artery disease were enrolled in a case-control study nested within the Cooperative Health Research in the Region of Augsburg (KORA) FF4 cohort and underwent comprehensive MRI assessment to characterize cerebral parameters (white matter lesions, microbleeds), cardiovascular parameters (carotid plaque, left ventricular function, and myocardial late gadolinium enhancement [LGE]), and metabolic parameters (hepatic proton-density fat fraction [PDFF] and subcutaneous and visceral abdominal fat). Among 400 subjects who underwent MRI, 103 subjects had prediabetes and 54 had established diabetes. Subjects with prediabetes had an increased risk for carotid plaque and adverse functional cardiac parameters, including reduced early diastolic filling rates as well as a higher prevalence of LGE compared with healthy control subjects. In addition, people with prediabetes had significantly elevated levels of PDFF and total and visceral fat. Thus, subjects with prediabetes show early signs of subclinical disease that include vascular, cardiac, and metabolic changes, as measured by whole-body MRI after adjusting for cardiometabolic risk factors.
authors.affiliation: Institute of Clinical Radiology, Ludwig-Maximilian-University Hospital, Munich, Germany fabian.bamberg@uni-tuebingen.de.|Department of Diagnostic and Interventional Radiology, University of Tübingen, Tübingen, Germany.|German Center for Cardiovascular Disease Research, Munich, Germany.
authors.forename: Fabian
authors.initials: F
authors.lastname: Bamberg
authors.affiliation: Institute of Clinical Radiology, Ludwig-Maximilian-University Hospital, Munich, Germany.|German Center for Cardiovascular Disease Research, Munich, Germany.
authors.forename: Holger
authors.initials: H
authors.lastname: Hetterich
authors.affiliation: Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
authors.forename: Susanne
authors.initials: S
authors.lastname: Rospleszcz
authors.affiliation: Institute of Clinical Radiology, Ludwig-Maximilian-University Hospital, Munich, Germany.|German Center for Cardiovascular Disease Research, Munich, Germany.
authors.forename: Roberto
authors.initials: R
authors.lastname: Lorbeer
authors.affiliation: Institute of Clinical Radiology, Ludwig-Maximilian-University Hospital, Munich, Germany.
authors.forename: Sigrid D
authors.initials: SD
authors.lastname: Auweter
authors.affiliation: Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany.
authors.forename: Christopher L
authors.initials: CL
authors.lastname: Schlett
authors.affiliation: Institute of Clinical Radiology, Ludwig-Maximilian-University Hospital, Munich, Germany.
authors.forename: Anina
authors.initials: A
authors.lastname: Schafnitzel
authors.affiliation: Institute of Clinical Radiology, Ludwig-Maximilian-University Hospital, Munich, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Bayerl
authors.affiliation: Institute of Clinical Radiology, Ludwig-Maximilian-University Hospital, Munich, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Schindler
authors.affiliation: Institute of Clinical Radiology, Ludwig-Maximilian-University Hospital, Munich, Germany.
authors.forename: Tobias
authors.initials: T
authors.lastname: Saam
authors.affiliation: Institute of Clinical Radiology, Ludwig-Maximilian-University Hospital, Munich, Germany.
authors.forename: Katharina
authors.initials: K
authors.lastname: Müller-Peltzer
authors.affiliation: Institute of Clinical Radiology, Ludwig-Maximilian-University Hospital, Munich, Germany.
authors.forename: Wieland
authors.initials: W
authors.lastname: Sommer
authors.affiliation: Department of Diagnostic and Interventional Radiology, University of Tübingen, Tübingen, Germany.
authors.forename: Tanja
authors.initials: T
authors.lastname: Zitzelsberger
authors.affiliation: Department of Diagnostic and Interventional Radiology, University of Tübingen, Tübingen, Germany.|Institute for Diabetes Research and Metabolic Diseases, Helmholtz Centre Tübingen, Tübingen, Germany.|German Centre for Diabetes Research, Tübingen, Germany.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Machann
authors.affiliation: Institute of Clinical Radiology, Ludwig-Maximilian-University Hospital, Munich, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Ingrisch
authors.affiliation: Institute of Clinical Radiology, Ludwig-Maximilian-University Hospital, Munich, Germany.
authors.forename: Sonja
authors.initials: S
authors.lastname: Selder
authors.affiliation: Department of Biometry and Epidemiology, German Diabetes Center, Düsseldorf, Germany.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Rathmann
authors.affiliation: Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.|KORA Myocardial Infarction Registry, Central Hospital of Augsburg, Augsburg, Germany.
authors.forename: Margit
authors.initials: M
authors.lastname: Heier
authors.affiliation: Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
authors.forename: Birgit
authors.initials: B
authors.lastname: Linkohr
authors.affiliation: Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.|KORA Myocardial Infarction Registry, Central Hospital of Augsburg, Augsburg, Germany.
authors.forename: Christa
authors.initials: C
authors.lastname: Meisinger
authors.affiliation: German Center for Cardiovascular Disease Research, Munich, Germany.|Institute for Cardiovascular Prevention, Ludwig-Maximilian-University Hospital, Munich, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Weber
authors.affiliation: Institute of Clinical Radiology, Ludwig-Maximilian-University Hospital, Munich, Germany.
authors.forename: Birgit
authors.initials: B
authors.lastname: Ertl-Wagner
authors.affiliation: Department of Cardiology, Ludwig-Maximilian-University Hospital, Munich, Germany.
authors.forename: Steffen
authors.initials: S
authors.lastname: Massberg
authors.affiliation: Institute of Clinical Radiology, Ludwig-Maximilian-University Hospital, Munich, Germany.
authors.forename: Maximilian F
authors.initials: MF
authors.lastname: Reiser
authors.affiliation: German Center for Cardiovascular Disease Research, Munich, Germany.|Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.|Institute for Cardiovascular Prevention, Ludwig-Maximilian-University Hospital, Munich, Germany.
authors.forename: Annette
authors.initials: A
authors.lastname: Peters
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism / Q000473:pathology; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003920:Diabetes Mellitus / Q000378:metabolism / Q000473:pathology*; D005951:Glucose Tolerance Test; D006801:Humans; D050152:Intra-Abdominal Fat / Q000378:metabolism / Q000473:pathology; D008099:Liver / Q000378:metabolism; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D011236:Prediabetic State / Q000378:metabolism / Q000473:pathology*; D012307:Risk Factors