title: Hepatic Issues and Complications Associated With Inflammatory Bowel Disease: A Clinical Report From the NASPGHAN Inflammatory Bowel Disease and Hepatology Committees.
abstract: Hepatobiliary disorders are common in patients with inflammatory bowel disease (IBD), and persistent abnormal liver function tests are found in approximately 20% to 30% of individuals with IBD. In most cases, the cause of these elevations will fall into 1 of 3 main categories. They can be as a result of extraintestinal manifestations of the disease process, related to medication toxicity, or the result of an underlying primary hepatic disorder unrelated to IBD. This latter possibility is beyond the scope of this review article, but does need to be considered in anyone with elevated liver function tests. This review is provided as a clinical summary of some of the major hepatic issues that may occur in patients with IBD.
authors.affiliation: *Division of Pediatric Gastroenterology and Nutrition, Golisano Children's Hospital, University of Rochester, Rochester, NY †Division of Pediatric Gastroenterology, University of Utah, Salt Lake City ‡Division of Pediatric General and Thoracic Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH §Division of Pediatric Gastroenterology and Hepatology, Seattle Children's Hospital, Seattle, WA ||Division of Pediatric Gastroenterology, Stanford Children's Health, Palo Alto, CA ¶Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH #Section of Pediatric Gastroenterology and Hepatology, Yale University School of Medicine, New Haven, CT **Division of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Harvard Medical School, Boston, MA ††Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia ‡‡Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA §§Division of Gastroenterology, Hepatology, and Nutrition, The Hospital for Sick Children, University of Toronto, Toronto, Canada.
authors.forename: Lawrence J
authors.initials: LJ
authors.lastname: Saubermann
authors.forename: Mark
authors.initials: M
authors.lastname: Deneau
authors.forename: Richard A
authors.initials: RA
authors.lastname: Falcone
authors.forename: Karen F
authors.initials: KF
authors.lastname: Murray
authors.forename: Sabina
authors.initials: S
authors.lastname: Ali
authors.forename: Rohit
authors.initials: R
authors.lastname: Kohli
authors.forename: Udeme D
authors.initials: UD
authors.lastname: Ekong
authors.forename: Pamela L
authors.initials: PL
authors.lastname: Valentino
authors.forename: Andrew B
authors.initials: AB
authors.lastname: Grossman
authors.forename: Elizabeth B
authors.initials: EB
authors.lastname: Rand
authors.forename: Maureen M
authors.initials: MM
authors.lastname: Jonas
authors.forename: Shehzad A
authors.initials: SA
authors.lastname: Saeed
authors.forename: Binita M
authors.initials: BM
authors.lastname: Kamath
mesh_terms: D001660:Biliary Tract Diseases / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D002648:Child; D003093:Colitis, Ulcerative / Q000150:complications*; D003424:Crohn Disease / Q000150:complications*; D006801:Humans; D008107:Liver Diseases / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy