title: Total Synthesis of (+)-Panacene.
abstract: The first total synthesis of the naturally occurring enantiomer of the marine bromoallene (+)-panacene is described. Central to this concise enantioselective synthesis was the use of a Noyori transfer hydrogenation for a Dynamic Kinetic Resolution (DKR) that set the desired absolute stereochemistry. A highly stereoselective Julia coupling was then used to install a Z-configured enyne, which enabled the biomimetic construction of the axially chiral bromoallene.
authors.affiliation: School of Chemistry, The University of Sydney , Sydney, New South Wales 2006, Australia.
authors.forename: Neanne
authors.initials: N
authors.lastname: Alnafta
authors.affiliation: School of Chemistry, The University of Sydney , Sydney, New South Wales 2006, Australia.
authors.forename: Johannes P
authors.initials: JP
authors.lastname: Schmidt
authors.affiliation: School of Chemistry, The University of Sydney , Sydney, New South Wales 2006, Australia.
authors.forename: Caroline L
authors.initials: CL
authors.lastname: Nesbitt
authors.affiliation: School of Chemistry, The University of Sydney , Sydney, New South Wales 2006, Australia.
authors.forename: Christopher S P
authors.identifier: 0000-0001-8930-7495
authors.initials: CS
authors.lastname: McErlean