title: Nanoparticle-Enabled Transdermal Drug Delivery Systems for Enhanced Dose Control and Tissue Targeting.
abstract: Transdermal drug delivery systems have been around for decades, and current technologies (e.g., patches, ointments, and creams) enhance the skin permeation of low molecular weight, lipophilic drugs that are efficacious at low doses. The objective of current transdermal drug delivery research is to discover ways to enhance skin penetration of larger, hydrophilic drugs and macromolecules for disease treatment and vaccination. Nanocarriers made of lipids, metals, or polymers have been successfully used to increase penetration of drugs or vaccines, control drug release, and target drugs to specific areas of skin in vivo. While more research is needed to identify the safety of nanocarriers, this technology has the potential to expand the use of transdermal routes of administration to a wide array of therapeutics. Here, we review the current state of nanoparticle skin delivery systems with special emphasis on targeting skin diseases.
authors.affiliation: Department of Environmental Medicine, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA. Brian_Palmer@URMC.Rochester.edu.
authors.forename: Brian C
authors.initials: BC
authors.lastname: Palmer
authors.affiliation: Department of Environmental Medicine, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA. Lisa_DeLouise@urmc.rochester.edu.|Department of Biomedical Engineering, School of Engineering and Applied Sciences, University of Rochester, Rochester, NY 14627, USA. Lisa_DeLouise@urmc.rochester.edu.|Department of Dermatology, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA. Lisa_DeLouise@urmc.rochester.edu.
authors.forename: Lisa A
authors.initials: LA
authors.lastname: DeLouise
mesh_terms: D000279:Administration, Cutaneous; D003876:Dermatitis, Atopic / Q000188:drug therapy*; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D046911:Macromolecular Substances / Q000493:pharmacokinetics; D053758:Nanoparticles / Q000627:therapeutic use*; D011565:Psoriasis / Q000188:drug therapy*; D012867:Skin / Q000378:metabolism; D012869:Skin Absorption / Q000187:drug effects* / Q000502:physiology
chemical_list: D046911:Macromolecular Substances
keywords: delivery; disease; drug; nanocarrier; nanoparticle; skin; transdermal