title: Salvage total laryngectomy after conservation laryngeal surgery for recurrent laryngeal squamous cell carcinoma.
abstract: The aim of the present study was to evaluate the oncological efficacy of salvage total laryngectomy in patients who had previously undergone supracricoid partial laryngectomy or transoral laser microsurgery for treatment of laryngeal squamous cell carcinoma. We retrospectively reviewed the medical, surgical and pathological records of 35 patients who underwent salvage total laryngectomy after recurrence of laryngeal cancer (following supracricoid partial laryngectomy or transoral laser microsurgery). Kaplan-Meier survival curves as well as univariate and multivariate analyses of prognostic factors were performed. No statistically significant differences were seen comparing the supracricoid partial laryngectomy group with the transoral laser microsurgery group for overall survival and disease-specific survival at 3 years (OS = 38% vs. 52%, p = 0.16; DSS = 40% vs. 61%, p = 0.057) or locoregional control at 2 years (LRC = 40% vs. 54%, p = 0.056). A trend indicating worse survival and locoregional control for supracricoid partial laryngectomy patients emerged. Preservation of the osteocartilaginous frame in transoral laser microsurgery could hypothetically result in better salvageability of anterior recurrences with extralaryngeal spread.
authors.affiliation: Department of Sensory Organs, ENT Section, "Sapienza" University of Rome, Italy.|Department of Otolaryngology-Head and Neck Surgery, Regina Elena National Cancer Institute, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: De Virgilio
authors.affiliation: Department of Sensory Organs, ENT Section, "Sapienza" University of Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Greco
authors.affiliation: Institute of Otorhinolaryngology, Università Cattolica del Sacro Cuore, Policlinico Agostino Gemelli, Rome, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Bussu
authors.affiliation: Department of Surgical Biotechnologies and Science, ENT Section, "Sapienza" University of Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Gallo
authors.affiliation: Department of Sensory Organs, ENT Section, "Sapienza" University of Rome, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Rosati
authors.affiliation: Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: S-H
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Department of Otolaryngology, Taichung Veterans General Hospital, Taichung City, Taiwan.
authors.forename: C-C
authors.initials: CC
authors.lastname: Wang
authors.affiliation: Department of Sensory Organs, ENT Section, "Sapienza" University of Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Conte
authors.affiliation: Department of Surgical Biotechnologies and Science, ENT Section, "Sapienza" University of Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Pagliuca
authors.affiliation: Department of Sensory Organs, ENT Section, "Sapienza" University of Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: De Vincentiis
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000601:surgery*; D000072700:Conservative Treatment; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000601:surgery*; D007825:Laryngectomy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000601:surgery*; D012189:Retrospective Studies; D016879:Salvage Therapy
keywords: Carcinoma; Larynx; Salvage total laryngectomy; Supracricoid laryngectomy; TRansoral laser microsurgery