title: MicroRNA biogenesis pathway genes polymorphisms and cancer risk: a systematic review and meta-analysis.
abstract: MicroRNAs (miRNAs) may promote the development and progression of human cancers. Therefore, components of the miRNA biogenesis pathway may play critical roles in human cancer. Single nucleotide polymorphisms (SNPs) or mutations in genes involved in the miRNA biogenesis pathway may alter levels of gene expression, affecting disease susceptibility. Results of previous studies on genetic variants in the miRNA biogenesis pathway and cancer risk were inconsistent. Therefore, a meta-analysis is needed to assess the associations of these genetic variants with human cancer risk. We searched for relevant articles from PubMed, Web of Science, CNKI, and CBM through Jun 21, 2016. In total, 21 case-control articles met all of the inclusion criteria for the study. Significant associations were observed between cancer risk and theDGCR8polymorphism rs417309 G >A (OR 1.22, 95% CI [1.04-1.42]), as well as theDICER1polymorphism rs1057035 TT (OR 1.13, 95% CI [1.05-1.22]). These SNPs exhibit high potential as novel diagnostic markers. Future studies with larger sample sizes and more refined analyses are needed to shed more light on these findings.
authors.affiliation: Southeast University, Department of Public Health, Nanjing, China.
authors.forename: Jieyu
authors.initials: J
authors.lastname: He
authors.affiliation: National Research Institute for Family Planning, Beijing, China.|Graduate School of Peking Union Medical College, Beijing, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Southeast University, Department of Public Health, Nanjing, China.
authors.forename: Wenbo
authors.initials: W
authors.lastname: Zhu
authors.affiliation: National Research Institute for Family Planning, Beijing, China.
authors.forename: Daxun
authors.initials: D
authors.lastname: Qi
authors.affiliation: Southeast University, Department of Public Health, Nanjing, China.
authors.forename: Lina
authors.initials: L
authors.lastname: Wang
authors.affiliation: Southeast University, Department of Public Health, Nanjing, China.
authors.forename: Jinfang
authors.initials: J
authors.lastname: Sun
authors.affiliation: Southeast University, Department of Public Health, Nanjing, China.
authors.forename: Bei
authors.initials: B
authors.lastname: Wang
authors.affiliation: National Research Institute for Family Planning, Beijing, China.|Graduate School of Peking Union Medical College, Beijing, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Ma
authors.affiliation: National Research Institute for Family Planning, Beijing, China.
authors.forename: Qiaoyun
authors.initials: Q
authors.lastname: Dai
authors.affiliation: Southeast University, Department of Public Health, Nanjing, China.
authors.forename: Xiaojin
authors.initials: X
authors.lastname: Yu
keywords: Cancer risk; Meta-analysis; MicroRNA biogenesis