title: Pore-Forming Toxins Trigger the Purge.
abstract: The intestinal epithelium responds to pathogens by coordinating microbial elimination with tissue repair, both required to survive an infection. In this issue of Cell Host & Microbe, Lee et al. (2016) discover a rapid and evolutionarily conserved response to pore-forming toxins in the gut, involving cytoplasm ejection and enterocyte regrowth.
authors.affiliation: Cornell Institute of Host-Microbe Interactions and Disease, Department of Entomology, Cornell University, Ithaca, NY 14853, USA.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Bonfini
authors.affiliation: Cornell Institute of Host-Microbe Interactions and Disease, Department of Entomology, Cornell University, Ithaca, NY 14853, USA. Electronic address: nicolas.buchon@cornell.edu.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Buchon
mesh_terms: D000818:Animals; D001419:Bacteria / Q000472:pathogenicity; D001427:Bacterial Toxins / Q000378:metabolism / Q000494:pharmacology*; D002462:Cell Membrane / Q000378:metabolism; D003593:Cytoplasm / Q000187:drug effects; D004195:Disease Models, Animal; D004331:Drosophila melanogaster / Q000382:microbiology; D004721:Endoplasmic Reticulum / Q000187:drug effects; D020895:Enterocytes / Q000187:drug effects; D041981:Gastrointestinal Tract / Q000187:drug effects / Q000378:metabolism / Q000382:microbiology; D006460:Hemolysin Proteins; D054884:Host-Pathogen Interactions / Q000502:physiology; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D051379:Mice; D008928:Mitochondria / Q000187:drug effects; D052899:Pore Forming Cytotoxic Proteins / Q000378:metabolism / Q000494:pharmacology*; D012706:Serratia marcescens / Q000472:pathogenicity
chemical_list: D001427:Bacterial Toxins; D006460:Hemolysin Proteins; D052899:Pore Forming Cytotoxic Proteins
keywords: Drosophila melanogaster; Serratia marcescens; cytoplasmic extrusion; enterocyte; gastrointestinal tract; megamitochondria; oral infection; pore-forming toxin; re-growth; resilience