title: Usefulness of a simple self-administered joint condition assessment sheet to predict the need for orthopaedic intervention in the management of haemophilic arthropathy.
abstract: BACKGROUND
  Detecting signs of joint deterioration is important for early effective orthopaedic intervention in managing haemophilic arthropathy.
  
  
  OBJECTIVE
  We developed a simple, patient self-administered sheet to evaluate the joint condition, and assessed the predictive ability of this assessment sheet for the need for an orthopaedic intervention.
  
  
  METHODS
  This was a single-centre, cross-sectional study. The association between the score of each of the four items of the assessment sheet (bleeding, swelling, pain and physical impairment) and the results of radiological findings and physical examinations based on Haemophilia Joint Health Score 2.1 was assessed. An optimal scoring system was explored by the area under the curve (AUC). The cut-off value for the need for surgery or physiotherapy was determined using the receiver operating characteristic curve procedure.
  
  
  RESULTS
  Forty-two patients were included. The 'physical impairment' item showed the highest correlation coefficient with the results of radiographic and physical examinations (range: 0.57-0.76). The AUC of finally adjusted scoring indicates good ability to discriminate between patients with and without a need for orthopaedic intervention. The positive predictive value was the highest at a cut-off value of 4 points for knees (63.0%) and ankles (70.0%), at 5 points for elbows (66.7%) and the highest predictive accuracy at the cut-off value of 4 points for all the joints. The linear trend of the need for an orthopaedic intervention was observed with an increasing score.
  
  
  CONCLUSIONS
  The joint condition assessment sheet can help clinicians assess the need for orthopaedic intervention for haemophilic arthropathy in Japanese patients with haemophilia.
authors.affiliation: Department of Orthopedic Surgery, Tokyo Medical University, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Masaoka
authors.affiliation: Department of Laboratory Medicine, Tokyo Medical University, Tokyo, Japan.|Department of Molecular Genetics of Coagulation Disorders, Tokyo Medical University, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Amano
authors.affiliation: Department of Joint Surgery, The Institute of Medical Science, The University of Tokyo, Research Hospital, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Takedani
authors.affiliation: Department of Laboratory Medicine, Tokyo Medical University, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.affiliation: Department of Laboratory Medicine, Tokyo Medical University, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Otaki
authors.affiliation: Department of Laboratory Medicine, Tokyo Medical University, Tokyo, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Seita
authors.affiliation: Department of Orthopedic Surgery, Tokyo Medical University, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tateiwa
authors.affiliation: Department of Orthopedic Surgery, Tokyo Medical University, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Shishido
authors.affiliation: Department of Orthopedic Surgery, Tokyo Medical University, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yamamoto
authors.affiliation: Department of Laboratory Medicine, Tokyo Medical University, Tokyo, Japan.|Department of Molecular Genetics of Coagulation Disorders, Tokyo Medical University, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Fukutake
mesh_terms: D000328:Adult; D006395:Hemarthrosis / Q000628:therapy*; D006467:Hemophilia A / Q000150:complications* / Q000628:therapy; D006801:Humans; D019637:Orthopedic Procedures; D010808:Physical Examination; D011795:Surveys and Questionnaires
keywords: haemophilia; haemophilic arthropathy; joint condition; joint condition assessment sheet; orthopaedic intervention; predictive ability