title: Linear Schiff-base fluorescence probe with aggregation-induced emission characteristics for Al3+detection and its application in live cell imaging.
abstract: A simple Schiff-base derivative with salicylaldehyde moieties as fluorescent probe 1 was reported by aggregation-induced emission (AIE) characterization for the detection of metal ions. Spectral analysis revealed that probe 1 was highly selective and sensitive to Al3+. The probe 1 was also subject to minimal interference from other common competitive metal ions. The detection limit of Al3+was 0.4 μM, which is considerably lower than the World Health Organization standard (7.41 μM), and the acceptable level of Al3+(1.85 μM) in drinking water. The Job's plot and the results of1H-NMR and FT-IR analyses indicated that the binding stoichiometry ratio of probe 1 to Al3+was 1:2. Probe 1 demonstrated a fluorescence-enhanced response upon binding with Al3+based on AIE characterization. This response was due to the restricted molecular rotation and increased rigidity of the molecular assembly. Probe 1 exhibited good biocompatibility, and Al3+was detected in live cells. Therefore, probe 1 is a promising fluorescence probe for Al3+detection in the environment.
authors.affiliation: Department of Chemistry, Shanxi Normal University, Linfen 041004, China.
authors.forename: Xiaoye
authors.initials: X
authors.lastname: Wen
authors.affiliation: Department of Chemistry, Shanxi Normal University, Linfen 041004, China. Electronic address: zhefengfan@126.com.
authors.forename: Zhefeng
authors.initials: Z
authors.lastname: Fan
mesh_terms: D000535:Aluminum / Q000032:analysis*; D066241:Carbon-13 Magnetic Resonance Spectroscopy; D005456:Fluorescent Dyes / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D066244:Proton Magnetic Resonance Spectroscopy; D012545:Schiff Bases / Q000737:chemistry*; D013050:Spectrometry, Fluorescence / Q000379:methods*
chemical_list: D005456:Fluorescent Dyes; D012545:Schiff Bases; D000535:Aluminum
keywords: Aggregation-induced emission; Al(3+); Fluorescent probe; Live cell imaging; Schiff base