title: Amino terminal pro brain natriuretic peptide predicts all-cause mortality in patients with chronic obstructive pulmonary disease: Systematic review and meta-analysis.
abstract: Natriuretic peptides (NPs) are a family of prognostic biomarkers in patients with heart failure (HF). HF is one of the most frequent comorbidities in patients with chronic obstructive pulmonary disease (COPD). However, the prognostic role of NP in COPD patients remains unclear. The aim of this meta-analysis was to evaluate the relation between NP and all-cause mortality in COPD patients. We performed a systematic review and meta-analysis of observational studies assessing prognostic implications of elevated NP levels on all-cause mortality in COPD patients. Nine studies were considered for qualitative analysis for a total of 2788 patients. Only two studies focused on Mid Regional-pro Atrial Natriuretic Peptide (MR-proANP) and brain natriuretic peptide (BNP), respectively, but seven studies focused on pro-BNP (NT-proBNP) and were included in the quantitative analysis. Elevated NT-proBNP values were related to increased risk of all-cause mortality in COPD patients both with and without exacerbation (hazard ratio (HR): 2.87, p < 0.0001 and HR: 3.34, p = 0.04, respectively). The results were confirmed also after meta-regression analysis for confounding factors (previous cardiovascular history, hypertension, HF, forced expiratory volume at 1 second and mean age). NT-proBNP may be considered a reliable predictive biomarker of poor prognosis in patients with COPD.
authors.affiliation: 1 Cardiology Unit, Azienda Ospedaliero-Universitaria S.Anna, Cona (FE), Italy.
authors.forename: Rita
authors.initials: R
authors.lastname: Pavasini
authors.affiliation: 2 Department of Anesthesia, Intensive Care and Pain Therapy, University of Pavia, Italy.|3 Anesthesia and Intensive Care, Emergency Department, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
authors.forename: Guido
authors.initials: G
authors.lastname: Tavazzi
authors.affiliation: 1 Cardiology Unit, Azienda Ospedaliero-Universitaria S.Anna, Cona (FE), Italy.
authors.forename: Simone
authors.initials: S
authors.lastname: Biscaglia
authors.affiliation: 4 Cardiology and Arrhythmology Clinic, Marche Polytechnic, University of Ancona, Ancona, Italy.
authors.forename: Federico
authors.initials: F
authors.lastname: Guerra
authors.affiliation: 1 Cardiology Unit, Azienda Ospedaliero-Universitaria S.Anna, Cona (FE), Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Pecoraro
authors.affiliation: 1 Cardiology Unit, Azienda Ospedaliero-Universitaria S.Anna, Cona (FE), Italy.
authors.forename: Fatima
authors.initials: F
authors.lastname: Zaraket
authors.affiliation: 1 Cardiology Unit, Azienda Ospedaliero-Universitaria S.Anna, Cona (FE), Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Gallo
authors.affiliation: 1 Cardiology Unit, Azienda Ospedaliero-Universitaria S.Anna, Cona (FE), Italy.
authors.forename: Giosafat
authors.initials: G
authors.lastname: Spitaleri
authors.affiliation: 5 Research Centre on Asthma and COPD, Section of Internal and Cardio-Respiratory Medicine, University of Ferrara, Ferrara, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Contoli
authors.affiliation: 1 Cardiology Unit, Azienda Ospedaliero-Universitaria S.Anna, Cona (FE), Italy.|6 Laboratorio per le Tecnologie delle Terapie Avanzate Center, Ferrara, Italy.|7 Maria Cecilia Hospital, GVM Care and Research, E. S. Health Science Foundation, Cotignola, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Ferrari
authors.affiliation: 1 Cardiology Unit, Azienda Ospedaliero-Universitaria S.Anna, Cona (FE), Italy.|6 Laboratorio per le Tecnologie delle Terapie Avanzate Center, Ferrara, Italy.|7 Maria Cecilia Hospital, GVM Care and Research, E. S. Health Science Foundation, Cotignola, Italy.
authors.forename: Gianluca
authors.initials: G
authors.lastname: Campo
mesh_terms: D015415:Biomarkers / Q000097:blood; D002423:Cause of Death; D006801:Humans; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011237:Predictive Value of Tests; D011379:Prognosis; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood* / Q000401:mortality*
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain
keywords: Chronic obstructive pulmonary disease; NT-proBNP; exacerbation; mortality; outcome