title: Synthesis of a Masked 2,3-Diaminoindole.
abstract: A three-step synthesis of masked 2,3-diaminoindole 1 from 2-iodo-3-nitro-1-(phenylsulfonyl)indole (2) has been developed. Treatment of 1 with trifluoroacetic acid generates the unstable 2,3-diamino-1-(phenylsulfonyl)indole (3), which can be trapped with α-dicarbonyl compounds to afford 5H-pyrazino[2,3-b]indoles 7-10.
authors.affiliation: Department of Chemistry, Dartmouth College , Hanover, New Hampshire 03755-3564, United States.
authors.forename: Philip Z
authors.initials: PZ
authors.lastname: Mannes
authors.affiliation: Department of Chemistry, Dartmouth College , Hanover, New Hampshire 03755-3564, United States.
authors.forename: Evans O
authors.initials: EO
authors.lastname: Onyango
authors.affiliation: Department of Chemistry, Dartmouth College , Hanover, New Hampshire 03755-3564, United States.
authors.forename: Gordon W
authors.initials: GW
authors.lastname: Gribble