title: Allergic sensitization in kidney transplanted patients - Is it a result of immunosuppressive agents or the sensitization of living donor?
abstract: BACKGROUND
  Allergic sensitization has been reported increasingly in organ transplant recipients. However, the pathogenesis of this sensitization has still not been clearly understood.
  
  
  OBJECTIVE
  The aim of this study was to evaluate allergic sensitization in kidney transplanted children and adolescents under immunosuppressive treatment.
  
  
  METHODS
  Twenty seven kidney-transplanted subjects were studied by standardized interviews from the International Study of Asthma and Allergies in Childhood criteria, skin prick test (SPT) and measurement of specific immunoglobulin E (s-IgE). Patients were considered to have allergic sensitization when presenting a positive SPT and/or s-IgE >0.35 kUA/l to at least one of the tested allergens. Patients with a history of allergic diseases accompanied by sensitization were accepted as allergic. We also performed SPT on the living donors of the allergic groups.
  
  
  RESULTS
  Seven patients (25.9%) were found to be sensitized to ≥1 common inhalant and 3 subjects (11.1%) additionally reported a corresponding present history of allergic diseases. All of the living donors' sensitized patients were allergic. New-onset post-transplantation food allergy was not documented in any patients.
  
  
  CONCLUSIONS
  This study supports the concept that not only immunosuppressant agents but also sensitization of living donors could be a significant contributor to allergic sensitization in kidney recipients.
authors.affiliation: Baskent University Faculty of Medicine, Department of Pediatric Allergy and Immunology, Adana Teaching and Medical Research Center Adana, Turkey.
authors.forename: Dilek
authors.initials: D
authors.lastname: Doğruel
authors.affiliation: Baskent University Faculty of Medicine, Department of Pediatric Allergy and Immunology, Adana Teaching and Medical Research Center Adana, Turkey.
authors.forename: Aytül
authors.initials: A
authors.lastname: Noyan
authors.affiliation: Baskent University Faculty of Medicine, Department of Pediatric Allergy and Immunology, Adana Teaching and Medical Research Center Adana, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Dursun
authors.affiliation: Baskent University Faculty of Medicine, Department of Pediatric Allergy and Immunology, Adana Teaching and Medical Research Center Adana, Turkey.
authors.forename: Nurcan
authors.initials: N
authors.lastname: Cengiz
mesh_terms: D000293:Adolescent; D000485:Allergens / Q000276:immunology; D001772:Blood Cell Count; D002648:Child; D003430:Cross-Sectional Studies; D004802:Eosinophilia; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000097:blood / Q000453:epidemiology* / Q000209:etiology*; D007114:Immunization; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology; D007166:Immunosuppressive Agents / Q000009:adverse effects; D016030:Kidney Transplantation / Q000009:adverse effects; D019520:Living Donors; D008297:Male; D012129:Respiratory Function Tests; D012882:Skin Tests
chemical_list: D000485:Allergens; D007166:Immunosuppressive Agents; D007073:Immunoglobulin E