title: Metformin: Restraining Nucleocytoplasmic Shuttling to Fight Cancer and Aging.
abstract: In this issue of Cell, Wu et al. employed C. elegans and human cell experiments to identify a pathway through which metformin increases lifespan and inhibits growth. A key transcriptional target, ACAD10, is activated when metformin induces nuclear exclusion of the GTPase RagC, thereby inhibiting mTORC1 through an unexpected mechanism.
authors.affiliation: Research Division, Joslin Diabetes Center, Boston, MA 02215, USA; Department of Genetics and Harvard Stem Cell Institute, Harvard Medical School, Boston MA 02115, USA.
authors.forename: Jorge Iván
authors.initials: JI
authors.lastname: Castillo-Quan
authors.affiliation: Research Division, Joslin Diabetes Center, Boston, MA 02215, USA; Department of Genetics and Harvard Stem Cell Institute, Harvard Medical School, Boston MA 02115, USA. Electronic address: keith.blackwell@joslin.harvard.edu.
authors.forename: T Keith
authors.initials: TK
authors.lastname: Blackwell
mesh_terms: D021581:Active Transport, Cell Nucleus; D000375:Aging / Q000187:drug effects; D000818:Animals; D017173:Caenorhabditis elegans / Q000187:drug effects*; D006801:Humans; D008687:Metformin / Q000494:pharmacology*; D009369:Neoplasms / Q000188:drug therapy
chemical_list: D008687:Metformin