title: Multiple Primary Melanomas: A Common Occurrence in Western Sweden.
abstract: Patients diagnosed with a single primary cutaneous melanoma are at increased risk of developing multiple primary melanomas. The aim of this study is to describe the epidemiology of multiple primary melanomas (invasive and in situ) in Western Sweden. Data from the Swedish Melanoma Registry from 1990 to 2013 revealed that 898 patients (7.4%) developed 2,037 multiple primary lesions and 11,254 patients developed single lesions. The proportion of subsequent lesions that were melanoma in situ was 47%, compared with 26% of first melanomas (p < 0.0001).The median and mean time to diagnosis of a subsequent melanoma was 38 and 58 months (95% confidence interval (CI), 53-62 months). In total, 49% of subsequent melanomas were detected within 3 years. Patients and physicians should be aware of the high proportion of multiple primary melanomas in Western Sweden, especially during the first years of follow-up.
authors.affiliation: Department of Dermatology and Venereology, Sahlgrenska Academy, SE-413 45 Gothenburg, Sweden. magdalena.claeson@vgregion.se.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Claeson
authors.forename: Paul
authors.initials: P
authors.lastname: Holmström
authors.forename: Stefan
authors.initials: S
authors.lastname: Hallberg
authors.forename: Martin
authors.initials: M
authors.lastname: Gillstedt
authors.forename: Helena
authors.initials: H
authors.lastname: Gonzalez
authors.forename: Ann-Marie
authors.initials: AM
authors.lastname: Wennberg
authors.forename: John
authors.initials: J
authors.lastname: Paoli
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000175:diagnosis / Q000453:epidemiology*; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis / Q000453:epidemiology*; D011379:Prognosis; D012042:Registries; D012189:Retrospective Studies; D012307:Risk Factors; D017678:Sex Distribution; D012878:Skin Neoplasms / Q000175:diagnosis / Q000453:epidemiology*; D013548:Sweden / Q000453:epidemiology; D013997:Time Factors