title: Comparative Study on Trace Element Excretions between Nonanuric and Anuric Patients Undergoing Continuous Ambulatory Peritoneal Dialysis.
abstract: Few studies have been reported on alterations of trace elements (TE) in peritoneal dialysis patients. Our objective was to investigate and assess the characteristics of daily TE excretions in continuous ambulatory peritoneal dialysis (CAPD) patients. This cross-sectional study included 61 CAPD patients (nonanuric/anuric: 45/16) and 11 healthy subjects in Wuhan, China between 2013 and 2014. The dialysate and urine of patients and urine of healthy subjects were collected. The concentrations of copper (Cu), zinc (Zn), selenium (Se), molybdenum (Mo), and arsenic (As) in dialysate and urine were determined using inductively coupled plasma mass spectrometer (ICP-MS). Various clinical variables were obtained from automatic biochemical analyzer. Daily Cu, Zn, Se, and Mo excretions in nonanuric patients were higher than healthy subjects, while arsenic excretion in anuric patients was lower. A strong and positive correlation was observed between Se and Mo excretion in both dialysate (β = 0.869,p< 0.010) and urine (β = 0.968,p< 0.010). Furthermore, the clinical variables associated with Se excretion were found to be correlated with Mo excretion. Our findings indicated that nonanuric CAPD patients may suffer from deficiency of some essential TEs, while anuric patients are at risk of arsenic accumulation. A close association between Se and Mo excretion was also found.
authors.affiliation: Department of Clinical Nutrition, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China. sy_xiang@hust.edu.cn.|Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China. sy_xiang@hust.edu.cn.
authors.forename: Siyun
authors.initials: S
authors.lastname: Xiang
authors.affiliation: Department of Clinical Nutrition, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China. yaoyingkk@126.com.|Department of Nephrology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China. yaoyingkk@126.com.
authors.forename: Ying
authors.initials: Y
authors.lastname: Yao
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China. wanyunan1122@163.com.
authors.forename: Yunan
authors.initials: Y
authors.lastname: Wan
authors.affiliation: Department of Nephrology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China. lwq19710228@163.com.
authors.forename: Wangqun
authors.initials: W
authors.lastname: Liang
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China. meng_ruiwei@163.com.
authors.forename: Ruiwei
authors.initials: R
authors.lastname: Meng
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China. JinQiMan1994@163.com.
authors.forename: Qiman
authors.initials: Q
authors.lastname: Jin
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China. m15927511308@163.com.
authors.forename: Nannan
authors.initials: N
authors.lastname: Wu
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China. xufangyi4527@126.com.
authors.forename: Fangyi
authors.initials: F
authors.lastname: Xu
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China. yingcj@hust.edu.cn.
authors.forename: Chenjiang
authors.initials: C
authors.lastname: Ying
authors.affiliation: Department of Clinical Nutrition, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China. 13886010354@163.com.
authors.forename: Xuezhi
authors.initials: X
authors.lastname: Zuo
mesh_terms: D000328:Adult; D000368:Aged; D001002:Anuria / Q000150:complications / Q000175:diagnosis / Q000628:therapy* / Q000652:urine; D001151:Arsenic / Q000652:urine; D015415:Biomarkers / Q000652:urine; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008982:Molybdenum / Q000652:urine; D009752:Nutritional Status; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects; D012643:Selenium / Q000652:urine; D014131:Trace Elements / Q000652:urine*; D016896:Treatment Outcome; D016482:Urinalysis; D055815:Young Adult
chemical_list: D015415:Biomarkers; D014131:Trace Elements; D008982:Molybdenum; D012643:Selenium; D001151:Arsenic
keywords: continuous ambulatory peritoneal dialysis; excretion; molybdenum; selenium; trace element