title: Phosphine-Catalyzed Enantioselective [2+4] Cycloaddition to Synthesize Pyrrolidin-2-one Fused Dihydropyrans Using α-Substituted Allenoates as C2Synthons.
abstract: A bifunctional phosphine-catalyzed highly enantioselective [2+4] cycloaddition of α-substituted allenoates with (E)-1-benzyl-4-olefinicpyrrolidine-2,3-diones has been achieved, giving pyrrolidin-2-one fused dihydropyran derivatives in moderate to good yields with excellent enantioselectivities (up to 98% ee). This reaction provides a useful catalytic asymmetric access to dihydropyran structural motifs.
authors.affiliation: Department of Applied Chemistry, China Agricultural University , Beijing 100193, China.
authors.forename: Chang
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Applied Chemistry, China Agricultural University , Beijing 100193, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Jia
authors.affiliation: Department of Applied Chemistry, China Agricultural University , Beijing 100193, China.
authors.forename: Cheng
authors.identifier: 0000-0002-8760-8152
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Applied Chemistry, China Agricultural University , Beijing 100193, China.
authors.forename: Zhenzhen
authors.initials: Z
authors.lastname: Gao
authors.affiliation: Department of Applied Chemistry, China Agricultural University , Beijing 100193, China.
authors.forename: Leijie
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Department of Applied Chemistry, China Agricultural University , Beijing 100193, China.
authors.forename: Chunhao
authors.initials: C
authors.lastname: Yuan
authors.affiliation: Department of Applied Chemistry, China Agricultural University , Beijing 100193, China.
authors.forename: Yumei
authors.initials: Y
authors.lastname: Xiao
authors.affiliation: Department of Applied Chemistry, China Agricultural University , Beijing 100193, China.
authors.forename: Hongchao
authors.identifier: 0000-0002-7356-4283
authors.initials: H
authors.lastname: Guo