title: Pectin-silica gels as matrices for controlled drug release in gastrointestinal tract.
abstract: The synthesis of pectin-silica gels for controlled drug release in gastrointestinal tract (GIT) using low methoxyl (LM) and high methoxy (HM) pectins and tetraethoxysilane (TEOS) as precursor is described. The FTIR spectra of the pectin-silica gels show intense absorption bands at 1246cm-1and 802cm-1corresponding to the vibrations COSi bonds, which absent in the FTIR spectra of the native pectins that indicate the formation covalent bond between silica and pectin macromolecules in the pectin-silica gels. Pectin-TEOS, pectin-Ca-TEOS and pectin-TEOS-Ca beads with mesalazine are synthesized by different combinations of sol-gel method using TEOS and ionotropic gelation method using calcium chloride. The best resistant of pectin-TEOS and pectin-Ca-TEOS beads during incubation in simulated gastric fluid for 2h and subsequently in simulated intestinal fluids for 18h is indicated. Pectin-TEOS beads are characterized by higher encapsulation efficiency (to 28%) than pectin-Ca-TEOS beads (to 16%). The drug release of pectin-silica beads in simulated GIT occurs gradually up to 80% and is directly dependent on the hardness of the beads. The surface morphology of beads is shown. The use of pectin-silica beads is promising with regard to the development of controlled release of drug formulations.
authors.affiliation: Institute of Physiology, Komi Science Centre, The Urals Branch of the Russian Academy of Sciences, 50, Pervomaiskaya Str., 167982 Syktyvkar, Russia. Electronic address: rodefex@mail.ru.
authors.forename: Fedor V
authors.initials: FV
authors.lastname: Vityazev
authors.affiliation: Institute of Physiology, Komi Science Centre, The Urals Branch of the Russian Academy of Sciences, 50, Pervomaiskaya Str., 167982 Syktyvkar, Russia.
authors.forename: Maiia I
authors.initials: MI
authors.lastname: Fedyuneva
authors.affiliation: Institute of Physiology, Komi Science Centre, The Urals Branch of the Russian Academy of Sciences, 50, Pervomaiskaya Str., 167982 Syktyvkar, Russia.
authors.forename: Victoria V
authors.initials: VV
authors.lastname: Golovchenko
authors.affiliation: Institute of Physiology, Komi Science Centre, The Urals Branch of the Russian Academy of Sciences, 50, Pervomaiskaya Str., 167982 Syktyvkar, Russia.
authors.forename: Olga A
authors.initials: OA
authors.lastname: Patova
authors.affiliation: Institute of Chemistry, Komi Science Centre, The Urals Branch of the Russian Academy of Sciences, 48, Pervomaiskaya Str., 167982 Syktyvkar, Russia.
authors.forename: Elena U
authors.initials: EU
authors.lastname: Ipatova
authors.affiliation: Federal Government-Financed Educational Institution of Higher Professional Education «Vyatka State University», 36, Moskovskaya Str., 610000, Kirov, Russia.
authors.forename: Eugene A
authors.initials: EA
authors.lastname: Durnev
authors.affiliation: Federal Government-Financed Educational Institution of Higher Professional Education «Vyatka State University», 36, Moskovskaya Str., 610000, Kirov, Russia.
authors.forename: Ekaterina A
authors.initials: EA
authors.lastname: Martinson
authors.affiliation: Federal Government-Financed Educational Institution of Higher Professional Education «Vyatka State University», 36, Moskovskaya Str., 610000, Kirov, Russia.
authors.forename: Sergey G
authors.initials: SG
authors.lastname: Litvinets
mesh_terms: D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D041981:Gastrointestinal Tract; D010368:Pectins / Q000737:chemistry*; D058428:Silica Gel / Q000737:chemistry*
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D058428:Silica Gel; D010368:Pectins
keywords: 5-Aminosalicylic acid (PubChem CID: 4075); Calcium chloride (PubChem CID: 5284359); Controlled release; Ethanol (PubChem CID: 702); FTIR spectra; Hydrochloric acid (PubChem CID: 313); Mesalazine; Pectin-silica beads; Potassium dihydrogen phosphate (PubChem CID: 516951); Sodium chloride (PubChem CID: 5234); Sodium metasilicate (PubChem CID: 23266); Tetraethoxysilane (PubChem CID: 6517); Texture analysis