title: Antimicrobial Susceptibility and Molecular Detection of Pertactin-producing and Pertactin-Deficient Bordetella pertussis.
abstract: Resurgence of Bordetella pertussis in recent years in the United States has coincided with a dramatic rise in pertactin-deficient strains. Limited data exist on detectability by nucleic acid amplification testing and antimicrobial susceptibility of pertactin-deficient B. pertussis. This study compares 15 pertactin-producing and 15 pertactin-deficient B. pertussis isolates. Pertactin-producing and pertactin-deficient strains were equally detected by nucleic acid amplification testing and were susceptible to antibiotics.
authors.affiliation: From the *Section of Infectious Diseases, Department of Pediatrics, St. Christopher's Hospital for Children and Drexel University College of Medicine, Philadelphia, Pennsylvania; and †Department of Pathology and Laboratory Medicine, St. Christopher's Hospital for Children and Drexel University College of Medicine, Philadelphia, Pennsylvania.
authors.forename: Emily
authors.initials: E
authors.lastname: Souder
authors.forename: Jennifer
authors.initials: J
authors.lastname: Vodzak
authors.forename: Alan T
authors.initials: AT
authors.lastname: Evangelista
authors.forename: Sarah S
authors.initials: SS
authors.lastname: Long
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics*; D001886:Bordetella pertussis / Q000187:drug effects* / Q000472:pathogenicity*; D004269:DNA, Bacterial / Q000235:genetics; D024881:Drug Resistance, Bacterial; D006801:Humans; D008826:Microbial Sensitivity Tests; D010566:Virulence Factors, Bordetella / Q000235:genetics*; D014917:Whooping Cough / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents; D001425:Bacterial Outer Membrane Proteins; D004269:DNA, Bacterial; D010566:Virulence Factors, Bordetella; C068929:pertactin