title: Effectiveness of Shin'iseihaito in Asthmatic Patients with Upper Airway Diseases: A Retrospective Cohort Study.
abstract: BACKGROUND
  Severe asthma is often associated with sinonasal diseases. Shin'iseihaito is a Japanese traditional herbal medicine, which is used to treat rhinosinusitis. However, its effectiveness in the treatment of asthma has not been elucidated.
  
  
  OBJECTIVE
  The aims of this study were to examine the effectiveness of Shin'iseihaito in asthmatic patients with upper airway disease and to identify the characteristics of responders.
  
  
  METHODS
  The medical records were retrospectively analyzed of asthmatic patients concomitant with upper airway disease in the outpatient department who had been administered Shin'iseihaito at least once from September 2011 to February 2015. They were classified into responders and non-responders, and the differences in characteristics were compared between the two groups.
  
  
  RESULTS
  Shin'iseihaito was effective in 21/40 (52.5%) patients. There was no significant difference between responders and non-responders with regard to age, sex, or age of asthma onset. However, the frequency of aspirin intolerance, the treatment step of asthma, and serum immunoglobulin E levels were significantly higher in responders than they were in non-responders (p = 0.022, p = 0.017, and p = 0.017, respectively). The frequency of occurrence of concomitant eosinophilic chronic rhinosinusitis was not significantly different in both groups.
  
  
  CONCLUSIONS
  Shin'iseihaito could be a potential alternative for the treatment of asthma in patients with upper airway diseases.
authors.affiliation: Department of Respiratory Medicine, Kitano Hospital, Tazuke Kofukai Medical Research Institute , Osaka, Japan .
authors.forename: Yuko
authors.initials: Y
authors.lastname: Katayama
authors.affiliation: Department of Respiratory Medicine, Kitano Hospital, Tazuke Kofukai Medical Research Institute , Osaka, Japan .
authors.forename: Satoshi
authors.initials: S
authors.lastname: Marumo
authors.affiliation: Department of Respiratory Medicine, Kitano Hospital, Tazuke Kofukai Medical Research Institute , Osaka, Japan .
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shima
authors.affiliation: Department of Respiratory Medicine, Kitano Hospital, Tazuke Kofukai Medical Research Institute , Osaka, Japan .
authors.forename: Masahiro
authors.initials: M
authors.lastname: Shirata
authors.affiliation: Department of Respiratory Medicine, Kitano Hospital, Tazuke Kofukai Medical Research Institute , Osaka, Japan .
authors.forename: Satoru
authors.initials: S
authors.lastname: Kawashima
authors.affiliation: Department of Respiratory Medicine, Kitano Hospital, Tazuke Kofukai Medical Research Institute , Osaka, Japan .
authors.forename: Takamasa
authors.initials: T
authors.lastname: Kitajima
authors.affiliation: Department of Respiratory Medicine, Kitano Hospital, Tazuke Kofukai Medical Research Institute , Osaka, Japan .
authors.forename: Daiki
authors.initials: D
authors.lastname: Inoue
authors.affiliation: Department of Respiratory Medicine, Kitano Hospital, Tazuke Kofukai Medical Research Institute , Osaka, Japan .
authors.forename: Ryo
authors.initials: R
authors.lastname: Itotani
authors.affiliation: Department of Respiratory Medicine, Kitano Hospital, Tazuke Kofukai Medical Research Institute , Osaka, Japan .
authors.forename: Minoru
authors.initials: M
authors.lastname: Sakuramoto
authors.affiliation: Department of Respiratory Medicine, Kitano Hospital, Tazuke Kofukai Medical Research Institute , Osaka, Japan .
authors.forename: Motonari
authors.initials: M
authors.lastname: Fukui
mesh_terms: D000328:Adult; D000368:Aged; D001249:Asthma / Q000150:complications* / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008518:Medicine, East Asian Traditional / Q000379:methods*; D008875:Middle Aged; D009298:Nasal Polyps / Q000150:complications*; D010366:Peak Expiratory Flow Rate; D028321:Plant Preparations / Q000627:therapeutic use*; D012189:Retrospective Studies; D012852:Sinusitis / Q000150:complications*
chemical_list: D028321:Plant Preparations
keywords: Kampo medicine; Shin'iseihaito; bronchial asthma; eosinophilic chronic rhinosinusitis; upper airway disease