title: Medical plant extracts and natural compounds with a hepatoprotective effect against damage caused by antitubercular drugs: A review.
abstract: Drug-induced liver injury encompasses a spectrum of diseases ranging from mild biochemical abnormalities to acute liver failure; example of this scenery is hepatotoxicity caused by the first-line antituberculous drugs isoniazid, rifampin and pyrazinamide, which are basic for treatment of drug-sensible and drug-resistant tuberculosis. In the search for pharmacological alternatives to prevent liver damage, antitubercular drugs have been the subject of numerous studies and published reviews, a great majority of them carried out by Asian countries. At the same time, hepatoprotectors from plant source are now emerging as a possible alternative to counteract the toxic effects of these therapeutic agents. The present review aims to highlight the most recent studies on the subject, based information published in scientific databases such as Scopus and PubMed.
authors.affiliation: Unidad de Investigación Médica en Farmacología, UMAE Hospital de Especialidades, Centro Médico Nacional-Siglo XXI, Instituto Mexicano del Seguro Social, México City, Mexico. Electronic address: adelinajim08@prodigy.net.mx.
authors.forename: María Adelina
authors.initials: MA
authors.lastname: Jiménez-Arellanes
authors.affiliation: Unidad de Investigación Médica en Farmacología, UMAE Hospital de Especialidades, Centro Médico Nacional-Siglo XXI, Instituto Mexicano del Seguro Social, México City, Mexico.
authors.forename: Gabriel Alfonso
authors.initials: GA
authors.lastname: Gutiérrez-Rebolledo
authors.affiliation: Unidad de Investigación Médica en Farmacología, UMAE Hospital de Especialidades, Centro Médico Nacional-Siglo XXI, Instituto Mexicano del Seguro Social, México City, Mexico.
authors.forename: Mariana
authors.initials: M
authors.lastname: Meckes-Fischer
authors.affiliation: Unidad de Investigación Médica en Farmacología, UMAE Hospital de Especialidades, Centro Médico Nacional-Siglo XXI, Instituto Mexicano del Seguro Social, México City, Mexico.
authors.forename: Rosalba
authors.initials: R
authors.lastname: León-Díaz
keywords: Antitubercular drugs-induced hepatotoxicity; Hepatoprotective effect; Medicinal plants; Natural compounds