title: Genetic causes of recurrent miscarriages.
abstract: Recurrent miscarriage is an important problem in reproductive health, which affects 1-5% of couples. The aim of this article is to summarize current knowledge on the genetic causes of recurrent miscarriage. It presents the most common parental genetic disorders (karyotype abnormalities, recessive diseases carrier status, dominant diseases and thrombophilia) connected with recurrent pregnancy loss, as well as research into other possible genetic causes. This review also sets out to demonstrate changes in the embryonic/fetal genome that may lead to abortions, and discusses the methods used to assess miscarried material, together with their advantages and disadvantages. Knowledge of the genetic background of miscarriages is important for prognosis, as well as the potential planning of prenatal diagnostics in subsequent pregnancies.
authors.affiliation: Department of Fetal Medicine and Gynecology, Medical University of Lodz, Poland. marta.kacprzak@stud.umed.lodz.pl.
authors.forename: Marta
authors.initials: M
authors.lastname: Kacprzak
authors.forename: Marta
authors.initials: M
authors.lastname: Chrzanowska
authors.forename: Beata
authors.initials: B
authors.lastname: Skoczylas
authors.forename: Hanna
authors.initials: H
authors.lastname: Moczulska
authors.forename: Maciej
authors.initials: M
authors.lastname: Borowiec
authors.forename: Piotr
authors.initials: P
authors.lastname: Sieroszewski
mesh_terms: D000026:Abortion, Habitual / Q000209:etiology / Q000235:genetics*; D000328:Adult; D002353:Carrier State; D002869:Chromosome Aberrations; D005260:Female; D030342:Genetic Diseases, Inborn / Q000150:complications*; D006801:Humans; D059785:Karyotype; D008423:Maternal Age; D010641:Phenotype; D011247:Pregnancy; D011295:Prenatal Care; D011296:Prenatal Diagnosis; D011379:Prognosis; D012307:Risk Factors; D016216:Ultrasonography, Prenatal
keywords: chromosome aberrations; genetic causes; recurrent miscarriages