title: Biorthogonal click chemistry on poly(lactic-co-glycolic acid)-polymeric particles.
abstract: Biodegradable polymeric materials are a key area of investigation in drug delivery and disease treatment. This is due to their proven clinical potential for payload protection, responsivity, and surface modification imparted by the versatile array of polymers available for their formulation. Here, we employ a novel biodegradable azide containing polymer in the formulation of polymeric nanoparticles and show that these particles can then be functionalized, with biorthogonal click reactions, to alter their surface appearance and their ability to interact with biological systems.
authors.affiliation: Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. aalmutairi@ucsd.edu.
authors.forename: Jason
authors.initials: J
authors.lastname: Olejniczak
authors.affiliation: Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. aalmutairi@ucsd.edu.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Collet
authors.affiliation: Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. aalmutairi@ucsd.edu.
authors.forename: Viet Anh
authors.initials: VA
authors.lastname: Nguyen Huu
authors.affiliation: Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. aalmutairi@ucsd.edu.
authors.forename: Minnie
authors.initials: M
authors.lastname: Chan
authors.affiliation: Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. aalmutairi@ucsd.edu.
authors.forename: Sangeun
authors.initials: S
authors.lastname: Lee
authors.affiliation: Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. aalmutairi@ucsd.edu.
authors.forename: Adah
authors.initials: A
authors.lastname: Almutairi
mesh_terms: D001386:Azides / Q000737:chemistry; D057930:Click Chemistry; D019344:Lactic Acid / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry; D010316:Particle Size; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D013499:Surface Properties
chemical_list: D001386:Azides; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid