title: Sexual dimorphic function of IL-17 in salivary gland dysfunction of the C57BL/6.NOD-Aec1Aec2 model of Sjögren's syndrome.
abstract: Interleukin (IL)-17 is one of the critical inflammatory cytokines that plays a direct role in development of Sjögren's syndrome (SjS), a systemic autoimmune disease characterized by a progressive chronic attack against the exocrine glands. The expression levels of IL-17 are correlated with a number of essential clinical parameters such as focus score and disease duration in human patients. Significantly immunological differences of Th17 cells were detected at the onset of clinical disease in female SjS mice compared to males. To further define the role of IL-17 in SjS and elucidate its involvement in the sexual dimorphism, we examined the systemic effect of IL-17 by genetically ablating Il-17 in the C57BL/6.NOD-Aec1Aec2, spontaneous SjS murine model. The results indicate that IL-17 is a potent inflammatory molecule in the induction of chemoattractants, cytokines, and glandular apoptosis in males and females. Elimination of IL-17 reduced sialadenitis more drastically in females than males. IL-17 is highly involved in modulating Th2 cytokines and altering autoantibody profiles which has a greater impact on changing plasma cells and germinal center B cell populations in females than males. The result supports a much more important role for IL-17 and demonstrates the sexual dimorphic function of IL-17 in SjS.
authors.affiliation: Department of Infectious Diseases and Pathology, University of Florida College of Veterinary Medicine, 2015 SW 16th Ave, Gainesville, Florida 32611, USA.
authors.forename: Alexandria
authors.initials: A
authors.lastname: Voigt
authors.affiliation: Department of Infectious Diseases and Pathology, University of Florida College of Veterinary Medicine, 2015 SW 16th Ave, Gainesville, Florida 32611, USA.
authors.forename: Lida
authors.initials: L
authors.lastname: Esfandiary
authors.affiliation: Department of Infectious Diseases and Pathology, University of Florida College of Veterinary Medicine, 2015 SW 16th Ave, Gainesville, Florida 32611, USA.
authors.forename: Arun
authors.initials: A
authors.lastname: Wanchoo
authors.affiliation: Department of Infectious Diseases and Pathology, University of Florida College of Veterinary Medicine, 2015 SW 16th Ave, Gainesville, Florida 32611, USA.
authors.forename: Patricia
authors.initials: P
authors.lastname: Glenton
authors.affiliation: Department of Infectious Diseases and Pathology, University of Florida College of Veterinary Medicine, 2015 SW 16th Ave, Gainesville, Florida 32611, USA.
authors.forename: Amy
authors.initials: A
authors.lastname: Donate
authors.affiliation: Department of Infectious Diseases and Pathology, University of Florida College of Veterinary Medicine, 2015 SW 16th Ave, Gainesville, Florida 32611, USA.
authors.forename: William F
authors.initials: WF
authors.lastname: Craft
authors.affiliation: Department of Infectious Diseases and Pathology, University of Florida College of Veterinary Medicine, 2015 SW 16th Ave, Gainesville, Florida 32611, USA.
authors.forename: Serena L M
authors.initials: SL
authors.lastname: Craft
authors.affiliation: Department of Infectious Diseases and Pathology, University of Florida College of Veterinary Medicine, 2015 SW 16th Ave, Gainesville, Florida 32611, USA.|Center for Orphan Autoimmune Disorders, University of Florida College of Dentistry, 1600 SW Archer Rd, Gainesville, Florida 32610, USA.
authors.forename: Cuong Q
authors.initials: CQ
authors.lastname: Nguyen
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology* / Q000473:pathology; D004195:Disease Models, Animal; D005260:Female; D018858:Germinal Center / Q000276:immunology* / Q000473:pathology; D020381:Interleukin-17 / Q000235:genetics / Q000276:immunology*; D008297:Male; D051379:Mice; D012469:Salivary Glands / Q000276:immunology* / Q000473:pathology; D012727:Sex Characteristics; D012859:Sjogren's Syndrome / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D018418:Th2 Cells / Q000276:immunology* / Q000473:pathology
chemical_list: D020381:Interleukin-17