title: Development of exclusively cutaneous sarcoidosis in patient with rheumatoid arthritis during treatment with etanercept.
abstract: We report the case of a patient with rheumatoid arthritis who, after 2 months of treatment with etanercept, showed disseminated asymptomatic violaceous papules. Biopsy of the skin lesion showed chronic granulomatous dermatitis with negative staining for fungi and acid-fast bacilli (AFB). After discontinuation of etanercept, the patient's condition improved. Although apparently paradoxical, cases of cutaneous and systemic sarcoidosis after anti-TNF medications have been reported in the literature, with very few cases presenting exclusive cutaneous involvement.
authors.affiliation: MD (Graduate degree in Dermatology), Resident in Dermatology, São Paulo, SP, Brazil.
authors.forename: Marcella Amaral Horta Barbosa
authors.initials: MA
authors.lastname: Vieira
authors.affiliation: Resident in Dermatology, Hospital do Servidor Público Estadual (HSPE), São Paulo, SP, Brazil.
authors.forename: Maria Isabel Ramos
authors.initials: MI
authors.lastname: Saraiva
authors.affiliation: Resident in Dermatology, Hospital do Servidor Público Estadual (HSPE), São Paulo, SP, Brazil.
authors.forename: Larissa Karine Leite da
authors.initials: LK
authors.lastname: Silva
authors.affiliation: Dermatologist, Specialist degree from the HSPE, São Paulo, SP, Brazil.
authors.forename: Rafael Cavanellas
authors.initials: RC
authors.lastname: Fraga
authors.affiliation: Dermatologist, Preceptor/Clinical Instructor, Instituto de Assistência Médica ao Servidor Público Estadual (IAMSPE), São Paulo, SP, Brazil.
authors.forename: Priscila
authors.initials: P
authors.lastname: Kakizaki
authors.affiliation: PhD in Dermatology from Faculdade de Medicina da Universidade de São Paulo (FMUSP). Head Dermatologist at the HSPE. Assistant Physician, Dermatology Service, Hospital das Clínicas, FMUSP, São Paulo, SP, Brazil.
authors.forename: Neusa Yuriko Sakai
authors.initials: NY
authors.lastname: Valente
mesh_terms: D018501:Antirheumatic Agents / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D000068800:Etanercept / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008875:Middle Aged; D012507:Sarcoidosis / Q000139:chemically induced*; D012871:Skin Diseases / Q000139:chemically induced*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
chemical_list: D018501:Antirheumatic Agents; D014409:Tumor Necrosis Factor-alpha; D000068800:Etanercept