title: Influence of Behçet's disease on first and second trimester serum screening markers.
abstract: OBJECTIVE
  Behçet's disease (BD) is a rare and multisystemic vasculitis disease. In this study, we investigated whether BD had any effect on the biochemical components of first and second trimester aneuploidy screening tests.
  
  
  METHODS
  A case-control retrospective study was conducted with 32 pregnant women with BD and 60 healthy pregnant women as controls. All pregnant womens' first trimester maternal serum pregnancy-associated plasma protein-A, free β-human chorionic gonadotropin and second trimester serum alpha-fetoprotein, unconjugated estriol and total human chorionic gonadotropin levels were examined from medical records. First and second serum screening markers were compared between pregnancies with BD and without.
  
  
  RESULTS
  There was no difference in age, body mass index and obstetric history between the groups. No significant difference was observed between the groups in terms of first and second trimester serum screening test results in the absence of aneuploidy or neural tube defect. Gestational age at birth, birth weight and neonatal intensive care admission rate were also similar between the groups.
  
  
  CONCLUSIONS
  Both first and second serum screening tests for Down syndrome may be recommended to pregnant women with BD without the need to readjust these markers. Pregnancy with BD was not associated with adverse perinatal outcome with respect to gestational age at birth or birth weight.
authors.affiliation: Department of Perinatology, Zekai Tahir Burak Women's Health Education and Training Hospital, Ankara, Turkey.
authors.forename: Zehra Vural
authors.initials: ZV
authors.lastname: Yılmaz
authors.affiliation: Department of Perinatology, Zekai Tahir Burak Women's Health Education and Training Hospital, Ankara, Turkey.
authors.forename: Gülenay Gençosmanoğlu
authors.initials: GG
authors.lastname: Türkmen
authors.affiliation: Department of Obstetrics and Gynaecology, Dr. Sami Ulus Women's and Children's Health Training and Research Hospital, Ankara, Turkey.
authors.forename: Elif
authors.initials: E
authors.lastname: Yılmaz
authors.affiliation: Department of Perinatology, Zekai Tahir Burak Women's Health Education and Training Hospital, Ankara, Turkey.
authors.forename: Korkut
authors.initials: K
authors.lastname: Dağlar
authors.affiliation: Department of Perinatology, Zekai Tahir Burak Women's Health Education and Training Hospital, Ankara, Turkey.
authors.forename: Ayşe
authors.initials: A
authors.lastname: Kırbaş
authors.affiliation: Department of Perinatology, Zekai Tahir Burak Women's Health Education and Training Hospital, Ankara, Turkey.
authors.forename: Cem
authors.initials: C
authors.lastname: Sanhal
authors.affiliation: Department of Perinatology, Zekai Tahir Burak Women's Health Education and Training Hospital, Ankara, Turkey.
authors.forename: Aykan
authors.initials: A
authors.lastname: Yücel
authors.affiliation: Department of Perinatology, Zekai Tahir Burak Women's Health Education and Training Hospital, Ankara, Turkey.
authors.forename: Dilek
authors.initials: D
authors.lastname: Uygur
mesh_terms: D000328:Adult; D000782:Aneuploidy; D001528:Behcet Syndrome / Q000097:blood* / Q000150:complications*; D015415:Biomarkers / Q000097:blood; D005260:Female; D005820:Genetic Testing; D006801:Humans; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000097:blood; D011262:Pregnancy Trimester, Second / Q000097:blood; D011296:Prenatal Diagnosis; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D015415:Biomarkers
keywords: Behçet's disease; outcome; pregnancy; screening markers