title: Tumor-cell targeting polydiacetylene micelles encapsulated with an antitumor drug for the treatment of ovarian cancer.
abstract: Peptide functionalized polydiacetylene (PDA) micelles encapsulated with camptothecin (CPT) kill ovarian cancer cells by the lysosome release of anticancer drug CPT. Moreover, the sub-30 nm PDA micelles penetrate efficiently into a tumor for enhanced therapeutic efficacy.
authors.affiliation: Key Labs for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, Shanghai 200237, China. jcwu@ecust.edu.cn.
authors.forename: Defan
authors.initials: D
authors.lastname: Yao
authors.affiliation: Key Labs for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, Shanghai 200237, China. jcwu@ecust.edu.cn.
authors.forename: Shang
authors.initials: S
authors.lastname: Li
authors.affiliation: Key Labs for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, Shanghai 200237, China. jcwu@ecust.edu.cn.
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Zhu
authors.affiliation: Key Labs for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, Shanghai 200237, China. jcwu@ecust.edu.cn.
authors.forename: Junchen
authors.initials: J
authors.lastname: Wu
authors.affiliation: Key Labs for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, Shanghai 200237, China. jcwu@ecust.edu.cn.
authors.forename: He
authors.initials: H
authors.lastname: Tian
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology; D002166:Camptothecin / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D008247:Lysosomes / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D008823:Micelles; D015394:Molecular Structure; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000473:pathology; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000473:pathology; D000078789:Polyacetylene Polymer; D011108:Polymers / Q000008:administration & dosage* / Q000737:chemistry; D053279:Polyynes / Q000008:administration & dosage* / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D008823:Micelles; D000078789:Polyacetylene Polymer; D011108:Polymers; D053279:Polyynes; C082361:polydiacetylene; D002166:Camptothecin