title: Sinonasal characteristics and quality of life by SNOT-22 in adult patients with cystic fibrosis.
abstract: The prevalence of chronic sinus disease in cystic fibrosis (CF) has gradually increased. Sinonasal involvement may have influence on pulmonary exacerbations and can have a negative impact on the quality of life. To evaluate nasal characteristics and quality of life in adult patients with CF; to establish an association and determine the predictors in SNOT-22 questionnaire. Cross- sectional study with prospective data collection was performed to evaluate adult CF patients. Patients underwent clinical evaluation, lung function tests, nasal endoscopy, and paranasal sinuses CT scan. All the patients answered the SNOT-22 questionnaire.
  
  
  RESULTS
  A total of 91 patients were allocated, of which, 45.1% were male. Patients were divided into three groups by SNOT-22. A high average age, late age of diagnosis, rhinitis symptoms, and clinical criteria for rhinosinusitis were observed more frequently in patients with high SNOT-22 scores (p < 0.05). Overall, 84.6% patients had abnormal CT findings, with aplasia/hypoplasia of the sphenoid sinus being the most common finding. In multiple regression model, age, female gender, and Pseudomonas aeruginosa in the sputum were associated with high SNOT-22 scores in the nasal domain. Hyposmia and lack of medial bulging of lateral nasal wall were variables associated with high SNOT-22 scores in the quality of life domain. In total score, there was a positive association with age and the presence of P. aeruginosa in sputum. Despite high prevalence of abnormal tomographic findings, patients reported mild intensity of sinonasal symptoms. Advanced age and the presence of P. aeruginosa were associated with higher SNOT-22 scores.
authors.affiliation: Programa de Pós-Graduação em Ciências Pneumológicas/Faculdade de Medicina, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil. suziekang@hotmail.com.|, Rua Coronel Marcelino, 40 sala 803 - Centro, Canoas, RS, 92310-060, Brazil. suziekang@hotmail.com.
authors.forename: Suzie Hyeona
authors.identifier: http://orcid.org/0000-0002-4723-2082
authors.initials: SH
authors.lastname: Kang
authors.affiliation: Serviço de Otorrinolaringologia/Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil.
authors.forename: Camila Degen
authors.initials: CD
authors.lastname: Meotti
authors.affiliation: Serviço de Otorrinolaringologia/Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil.
authors.forename: Karine
authors.initials: K
authors.lastname: Bombardelli
authors.affiliation: Serviço de Otorrinolaringologia/Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil.|Departmento de Oftalmologia e Otorrinolaringologia, Faculdade de Medicina, UFRGS, Porto Alegre, Brazil.
authors.forename: Otávio Bejzman
authors.initials: OB
authors.lastname: Piltcher
authors.affiliation: Departmento de Medicina Interna, Faculdade de Medicina, UFRGS, Porto Alegre, Brazil.|Serviço de Pneumologia, HCPA, Porto Alegre, Brazil.
authors.forename: Paulo
authors.initials: P
authors.lastname: de Tarso Roth Dalcin
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002908:Chronic Disease; D003430:Cross-Sectional Studies; D003550:Cystic Fibrosis / Q000150:complications* / Q000000981:diagnostic imaging; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D008297:Male; D011446:Prospective Studies; D011552:Pseudomonas Infections / Q000150:complications* / Q000175:diagnosis; D011550:Pseudomonas aeruginosa; D011788:Quality of Life; D012220:Rhinitis / Q000150:complications* / Q000175:diagnosis; D012720:Severity of Illness Index; D012852:Sinusitis / Q000150:complications* / Q000175:diagnosis; D011795:Surveys and Questionnaires; D014057:Tomography, X-Ray Computed; D055815:Young Adult
keywords: Cystic fibrosis; Nasal polyposis; Quality of life; Rhinosinusitis; SNOT-22