title: Low dose prophylaxis in Tunisian children with haemophilia.
abstract: BACKGROUND
  Low dose prophylaxis could be recommended in countries with limited resources.
  
  
  OBJECTIVE
  We report our single centre experience in children with haemophilia.
  
  
  METHODS
  Fifty-five children were included in our study with a weekly median dose of 30 UI kg-1given once, twice or thrice a week. Age of initiation of prophylaxis is 5.32 years (0.64-11.44). Outcome assessment used were number of bleeding before and after initiating prophylaxis, haemophilia joint health score (HJHS), functional independence score in haemophilia (FISH) and quality of life with the Haemo-QoL.
  
  
  RESULTS
  Reduction of number of bleeding was clear in all patients; HJHS, FISH and Haemo-QOL were satisfactory.
  
  
  CONCLUSIONS
  Low dose prophylaxis is effective and better than on-demand therapy. It should be the starting point for prophylaxis in countries with limited resources.
authors.affiliation: Hemophilia Center Aziza Othmana Hospital, Tunis, Tunisia.|Tunis Medical University of Tunis, UR14ES11, Tunis, Tunisia.
authors.forename: E
authors.initials: E
authors.lastname: Gouider
authors.affiliation: Tunis Medical University of Tunis, UR14ES11, Tunis, Tunisia.
authors.forename: L
authors.initials: L
authors.lastname: Jouini
authors.affiliation: Hemophilia Center Aziza Othmana Hospital, Tunis, Tunisia.|Tunis Medical University of Tunis, UR14ES11, Tunis, Tunisia.
authors.forename: M
authors.initials: M
authors.lastname: Achour
authors.affiliation: Tunis Medical University of Tunis, UR14ES11, Tunis, Tunisia.
authors.forename: H
authors.initials: H
authors.lastname: Elmahmoudi
authors.affiliation: Hemophilia Center Aziza Othmana Hospital, Tunis, Tunisia.|Tunis Medical University of Tunis, UR14ES11, Tunis, Tunisia.
authors.forename: K
authors.initials: K
authors.lastname: Zahra
authors.affiliation: Hemophilia Center Aziza Othmana Hospital, Tunis, Tunisia.|Orthopedy Department, Children Hospital Bechir Hamza, Tunis, Tunisia.
authors.forename: W
authors.initials: W
authors.lastname: Saied
authors.affiliation: Hemophilia Center Aziza Othmana Hospital, Tunis, Tunisia.|Tunis Medical University of Tunis, UR14ES11, Tunis, Tunisia.
authors.forename: B
authors.initials: B
authors.lastname: Meddeb
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D006467:Hemophilia A / Q000188:drug therapy*; D006801:Humans; D008297:Male; D014416:Tunisia
keywords: functional independence score in haemophilia; haemophilia; haemophilia joint health score; low dose prophylaxis; prophylaxis