title: [Effect of different blood pressure control targets within 48 h after hypertensive cerebral hemorrhage on hematoma enlargement and prognosis].
abstract: OBJECTIVE
  To study the effect of different blood pressure control targets on hematoma enlargement and prognosis in patients within 48 h after hypertensive cerebral hemorrhage (HCH).
  
  
  METHODS
  Between January, 2013 and July, 2016, 102 patients with HCH were randomized into group A (51 cases) and group B (51 cases) with different systolic blood pressure (SBP) control targets within 48 h. The patients in group A were given early active antihypertensive treatment with SBP control target of 130-140 mm Hg; those in group B received standard antihypertensive treatment with SBP control target of 170-180 mm Hg. The changes in the volume of hematomas and the patients' prognosis were compared between the two groups.
  
  
  RESULTS
  After 48 h of treatment, SBP, hematoma volume and the National Institutes of Health Stroke Scale (NIHSS) score were significantly lower and Glasgou Coma Scale (GCS) score was significantly higher in group A than in group B (P<0.01 or 0.05). After 30 days of treatment, the patients in group A showed significantly better indicators of treatment efficacy than those in group B (Z=2.331, P=0.020). The mortality rate was lower in group A than in group B, but the difference was not statistically significant (Χ2=2.772, P=0.096).
  
  
  CONCLUSIONS
  Early active antihypertensive treatment is safe and feasible in patients with HCH and can reduce the enlargement of the hematomas, alleviate deterioration of neurological function, and improve the prognosis of the patients.
authors.affiliation: First Division of Department of Neurology, Zhengzhou People's Hospital, Zhengzhou 450000, China. E-mail: zhanghongtaozzs@163.com.
authors.forename: Hong-Tao
authors.initials: HT
authors.lastname: Zhang
authors.forename: Meng
authors.initials: M
authors.lastname: Yu
authors.forename: Ya-Fang
authors.initials: YF
authors.lastname: Ren
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
authors.forename: Shu-Ling
authors.initials: SL
authors.lastname: Zhang
authors.forename: Sheng-Qi
authors.initials: SQ
authors.lastname: Fu
authors.forename: Dao-Pei
authors.initials: DP
authors.lastname: Zhang
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure; D002543:Cerebral Hemorrhage / Q000188:drug therapy*; D006406:Hematoma / Q000188:drug therapy*; D006801:Humans; D006984:Hypertrophy; D020299:Intracranial Hemorrhage, Hypertensive; D011379:Prognosis; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents