title: Pathophysiology of Myocardial Infarction and Acute Management Strategies.
abstract: On an annual basis, 13.2% of all deaths are attributable to coronary artery disease (CAD), which makes CAD - with 7.4 million deaths - the leading cause of death in the world. In this review, we discuss current knowledge in the pathophysiology of atherosclerosis with its progression to stable CAD and its destabilization and complication with thrombus formation - myocardial infarction (MI). Next, we describe mechanisms of myocardial cell death in MI, the ischemia-reperfusion injury, leftventricular remodeling and complications of MI. Furthermore, we add acute management strategies concentrating on medical therapy, a decision on the reperfusion strategy, timing and cardiac protection by ischemic preconditioning, post-conditioning and remote ischemic conditioning.
authors.affiliation: General Hospital Rakičan, Murska Sobota, Slovenia.
authors.forename: Miha
authors.initials: M
authors.lastname: Tibaut
authors.affiliation: Department of Anaesthesiology, Intensive Care and Pain Management, University Medical Centre Maribor, Maribor, Slovenia.
authors.forename: Dusan
authors.initials: D
authors.lastname: Mekis
authors.affiliation: Institute of Histology and Embryology, Faculty of Medicine University of Ljubljana, Korytkova 2, 1105 Ljubljana, Slovenia.
authors.forename: Daniel
authors.initials: D
authors.lastname: Petrovic
mesh_terms: D003324:Coronary Artery Disease / Q000503:physiopathology / Q000628:therapy; D019468:Disease Management; D006801:Humans; D009203:Myocardial Infarction / Q000503:physiopathology* / Q000628:therapy*
keywords: Atherosclerosis; coronary artery disease; management; medical therapy; myocardial conditioning; myocardial infarction; pathophysiology