title: To PFKFB3 or Not to PFKFB3, That Is the Question.
abstract: In this issue of Cancer Cell, Cantelmo et al. describe how reduction of PFKFB3 enzyme activity can promote vascular normalization. The authors show in turn how this affects vascular permeability and can ultimately improve the efficacy of chemotherapeutic agents.
authors.affiliation: Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK.
authors.forename: Cristina
authors.initials: C
authors.lastname: Branco
authors.affiliation: Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK; Department of Cell and Molecular Biology, The Karolinska Institute, Stockholm S-171 77, Sweden. Electronic address: rsj33@cam.ac.uk.
authors.forename: Randall S
authors.initials: RS
authors.lastname: Johnson
mesh_terms: D000970:Antineoplastic Agents; D006801:Humans; D025481:Phosphofructokinase-2
chemical_list: D000970:Antineoplastic Agents; D025481:Phosphofructokinase-2