title: Division modes and physical asymmetry in cerebral cortex progenitors.
abstract: Neural stem cells go through a sequence of timely regulated gene expression and pattern of division mode to generate diverse neurons during brain development. During vertebrate cerebral cortex development, neural stem cells begin with proliferative symmetric divisions, subsequently undergo neurogenic asymmetric divisions, and finally gliogenic divisions. In this review, we explore the relationship between stem cell versus neural fate specification and the division mode. Specifically, we discuss recent findings on the mechanisms of asymmetric divisions, division mode, and developmental progression of neural progenitor identity.
authors.affiliation: Univ Lyon, Universite Claude Bernard Lyon 1, Inserm, Stem Cell and Brain Research Institute U1208, 69500 Bron, France.
authors.forename: Delphine
authors.initials: D
authors.lastname: Delaunay
authors.affiliation: Anatomy and Cell Biology, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan.
authors.forename: Ayano
authors.initials: A
authors.lastname: Kawaguchi
authors.affiliation: Univ Lyon, Universite Claude Bernard Lyon 1, Inserm, Stem Cell and Brain Research Institute U1208, 69500 Bron, France. Electronic address: Colette.dehay@inserm.fr.
authors.forename: Colette
authors.initials: C
authors.lastname: Dehay
authors.affiliation: Laboratory for Cell Asymmetry, RIKEN Center for Developmental Biology, Kobe 650-0047, Japan. Electronic address: fumio@cdb.riken.jp.
authors.forename: Fumio
authors.initials: F
authors.lastname: Matsuzaki
mesh_terms: D000818:Animals; D002455:Cell Division; D002540:Cerebral Cortex / Q000166:cytology* / Q000196:embryology; D058953:Neural Stem Cells / Q000166:cytology*; D055495:Neurogenesis / Q000502:physiology