title: Application of phage peptide display technology for the study of food allergen epitopes.
abstract: Phage peptide display technology has been used to identify IgE-binding mimotopes (mimics of natural epitopes) that mimic conformational epitopes. This approach is effective in the characterization of those epitopes that are important for eliciting IgE-mediated allergic responses by food allergens and those that are responsible for cross-reactivity among allergenic food proteins. Application of this technology will increase our understanding of the mechanisms whereby food allergens elicit allergic reactions, will facilitate the discovery of diagnostic reagents and may lead to mimotope-based immunotherapy.
authors.affiliation: Division of Allergy and Clinical Immunology, Departments of Medicine and Immunology, University of Colorado Denver, Aurora, CO, USA.
authors.forename: Xueni
authors.initials: X
authors.lastname: Chen
authors.affiliation: Division of Allergy and Clinical Immunology, Departments of Medicine and Immunology, University of Colorado Denver, Aurora, CO, USA.
authors.forename: Stephen C
authors.initials: SC
authors.lastname: Dreskin
mesh_terms: D000485:Allergens / Q000737:chemistry*; D052179:Antigens, Plant / Q000737:chemistry / Q000276:immunology; D001435:Bacteriophages; D003429:Cross Reactions; D000939:Epitopes / Q000737:chemistry* / Q000276:immunology; D005512:Food Hypersensitivity / Q000175:diagnosis / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D018716:Molecular Mimicry; D019151:Peptide Library
chemical_list: D000485:Allergens; D052179:Antigens, Plant; D000939:Epitopes; D019151:Peptide Library; D007073:Immunoglobulin E
keywords: Conformational epitope; Food allergy; IgE epitope; Mimotopes; Phage peptide display