title: One gene, two paracellular ion channels-claudin-10 in the kidney.
abstract: Claudins are tight junction membrane proteins and regulate the paracellular passage of ions and water. They can seal the paracellular cleft against solute passage but also form paracellular channels. They are tetraspan proteins with two extracellular segments. Claudin-10 exists in at least two functional isoforms, claudin-10a and claudin-10b, that differ in their first transmembrane segment and first extracellular segment. Both isoforms act as selective paracellular ion channels, either for anions (claudin-10a) or for cations (claudin-10b). Their diverse functions are reflected in completely different expression patterns in the body, especially in the kidney. Their structural and functional similarities and differences make them ideal subjects to study determinants of claudin charge selectivity and pore formation. This review aims to summarise research on permeability properties of the claudin-10 channels and their role in physiology and pathophysiology of the kidney.
authors.affiliation: Institute of Physiology, Christian-Albrechts-University Kiel, Hermann-Rodewald-Straße 5, 24118, Kiel, Germany. s.milatz@physiologie.uni-kiel.de.
authors.forename: Susanne
authors.identifier: 0000-0001-9893-0473
authors.initials: S
authors.lastname: Milatz
authors.affiliation: Institute of Clinical Physiology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: Tilman
authors.initials: T
authors.lastname: Breiderhoff
mesh_terms: D000818:Animals; D057167:Claudins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007473:Ion Channels / Q000235:genetics / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism*; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism; D019108:Tight Junctions / Q000378:metabolism
chemical_list: D057167:Claudins; D007473:Ion Channels; D008565:Membrane Proteins; C502009:claudin 10
keywords: Claudin-10 knock out; Mosaic; Paracellular transport; Thick ascending limb; Tight junction