title: Comparison of the anti-inflammatory effects of fluorometholone 0.1% combined with levofloxacin 0.5% and tobramycin/dexamethasone eye drops after cataract surgery.
abstract: OBJECTIVE
  To compare the combination of fluorometholone 0.1% and levofloxacin 0.5% to tobramycin/dexamethasone eye drops in controlling inflammation and preventing infection after phacoemulsification with an intraocular lens implantation.
  
  
  METHODS
  Sixty eyes from 60 patients undergoing cataract phacoemulsification were randomized into two groups; half of the patients were treated with fluorometholone (6 times/d) combined with levofloxacin (4 times/d), while the other half were treated with tobramycin/dexamethasone (4 times/d) eye drops for one week. Preoperative and postoperative intraocular pressure, aqueous flare, corneal thickness, and signs and symptoms were recorded before the operation and 1wk following treatments.
  
  
  RESULTS
  There were no statistically significant differences between the two groups in corneal thickness (P≥0.629), aqueous flare (P≥0.398), and signs and symptoms scores (P≥0.350) at each time point. Ocular hypertension was only observed in two eyes in the tobramycin/dexamethasone group.
  
  
  CONCLUSIONS
  Fluorometholone combined with levofloxacin treatment shows comparable efficacy but without the tendency to increase intraocular pressure; thus, it might be a better regimen for postoperative use.
authors.affiliation: Eye Center, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang Province, China.
authors.forename: Pei-Qing
authors.initials: PQ
authors.lastname: Chen
authors.affiliation: Zhejiang Hospital of Traditional Chinese Medicine, Hangzhou 310006, Zhejiang Province, China.
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Han
authors.affiliation: Eye Center, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang Province, China.
authors.forename: Ya-Nan
authors.initials: YN
authors.lastname: Zhu
authors.affiliation: Eye Center, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang Province, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Xu
keywords: fluorometholone; inflammation; levofloxacin; phacoemulsification; tobramycin/dexamethasone