title: Enhanced Corrosion Resistance and Biocompatibility of Magnesium Alloy by Mg-Al-Layered Double Hydroxide.
abstract: Magnesium (Mg) and its alloys have been suggested as revolutionary biodegradable materials. However, fast degradation hinders its clinic application. To improve the corrosion resistance and biocompatibility of Mg-Nd-Zn-Zr alloy (JDBM), magnesium-aluminum-layered double hydroxide (Mg-Al LDH) was successfully introduced into Mg(OH)2coating by hydrothermal treatment. The anions in the interlayer of Mg-Al LDH can be replaced by chloride ions, resulting in a relatively low chloride ion concentration near the surface of the coating. The favorable corrosion resistance of the coating was proved by polarization curves and hydrogen collection test. The Mg-Al LDH significantly promoted cell adhesion, migration and proliferation in vitro. In addition, the coating almost fulfilled the request of the clinical application in the hemolysis ratio test. Finally, in vivo results indicated that the coating offered the greatest long-lasting protection from corrosion and triggered the mildest inflammation comparing to the pure Mg(OH)2coatings and untreated magnesium alloy. Mg(OH)2coating containing Mg-Al LDH in the present study shows a promising application in improving anticorrosion and biocompatibility of Mg alloys, and might act as a platform for a further modification of Mg alloys ascribed to its special layer structure.
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences , Shanghai 200050, China.|University of Chinese Academy of Sciences , Beijing 100049, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Peng
authors.affiliation: Department of Cardiac Surgery, Zhongshan Hospital, Fudan University , Shanghai 200032, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Li
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences , Shanghai 200050, China.|University of Chinese Academy of Sciences , Beijing 100049, China.
authors.forename: Donghui
authors.initials: D
authors.lastname: Wang
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences , Shanghai 200050, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Tian
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences , Shanghai 200050, China.|University of Chinese Academy of Sciences , Beijing 100049, China.
authors.forename: Yaxin
authors.initials: Y
authors.lastname: Tian
authors.affiliation: National Engineering Research Center of Light Alloys Net Forming, Shanghai Jiao Tong University , Shanghai 200240, China.
authors.forename: Guangyin
authors.initials: G
authors.lastname: Yuan
authors.affiliation: Department of Cardiac Surgery, Zhongshan Hospital, Fudan University , Shanghai 200032, China.
authors.forename: Demin
authors.initials: D
authors.lastname: Xu
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences , Shanghai 200050, China.
authors.forename: Xuanyong
authors.identifier: http://orcid.org/0000-0001-9440-8143
authors.initials: X
authors.lastname: Liu
mesh_terms: D000497:Alloys / Q000737:chemistry*; D002448:Cell Adhesion; D020099:Coated Materials, Biocompatible; D003343:Corrosion; D008274:Magnesium; D008422:Materials Testing
chemical_list: D000497:Alloys; D020099:Coated Materials, Biocompatible; D008274:Magnesium
keywords: biocompatibility; corrosion; ion exchange; layer double hydroxide; magnesium alloys