title: Recombinant alpha-1-microglobulin: a potential treatment for preeclampsia.
abstract: Preeclampsia is a serious pregnancy-specific condition, affecting 10 million women annually worldwide. No specific treatment is currently available. Recent studies have demonstrated abnormal production and accumulation of free fetal hemoglobin in the preeclamptic placenta, and identified subsequent leakage into the maternal circulation as an important factor in the development of preeclampsia. A recombinant version of alpha-1-microglobulin, an endogenous well-characterized heme and radical scavenger, has been developed. Intravenous administration of recombinant alpha-1-microglobulin in animal models has been proved to eliminate or significantly reduce the manifestations of preeclampsia. Recombinant alpha-1-microglobulin has the potential to become the first specific therapy for preeclampsia.
authors.affiliation: Department of Medical Affairs, A1M Pharma, Lund, Sweden. Electronic address: rg@a1m.se.
authors.forename: Rolf
authors.initials: R
authors.lastname: Gunnarsson
authors.affiliation: Lund University, Department of Clinical Sciences Lund, Infection Medicine, Lund, Sweden.
authors.forename: Bo
authors.initials: B
authors.lastname: Åkerström
authors.affiliation: Lund University, Skane University Hospital, Department of Clinical Sciences Lund, Obstetrics and Gynecology, Lund University, Lund, Sweden.
authors.forename: Stefan R
authors.initials: SR
authors.lastname: Hansson
authors.affiliation: Lund University, Department of Clinical Sciences Lund, Infection Medicine, Lund, Sweden; Lund University, Skane University Hospital, Department of Clinical Sciences Lund, Pediatrics, Lund, Sweden.
authors.forename: Magnus
authors.initials: M
authors.lastname: Gram
mesh_terms: D000510:Alpha-Globulins / Q000494:pharmacology* / Q000627:therapeutic use*; D000818:Animals; D005260:Female; D006801:Humans; D010920:Placenta / Q000187:drug effects; D011225:Pre-Eclampsia / Q000188:drug therapy*; D011247:Pregnancy; D011994:Recombinant Proteins / Q000494:pharmacology* / Q000627:therapeutic use*
chemical_list: D000510:Alpha-Globulins; D011994:Recombinant Proteins; C016001:alpha-1-microglobulin