title: Excretory Function of Intestinal Tract Enhanced in Kidney Impaired Rats Caused by Adenine.
abstract: The main aim of the study was to prove the compensative effect of intestine for renal function. Rat kidney was impaired by intragastrically administrating adenine (400 mg per day for 5 days). Intestinal tract was harvested and equally divided into 20 segments except cecum. Kidneys were harvested and histologically examined with hematoxylin-eosin staining kits. Uric acid, urea (BUN), and creatinine in serum were determined with assay kits, and BUN and creatinine in every intestinal segment were also determined. The results showed that adenine was able to increase uric acid level in serum from 20.98 ± 6.98μg/mL to 40.77 ± 7.52μg/mL and cause renal function damage with BUN (from 3.87 ± 0.62 mM to 12.33 ± 3.27 mM) and creatinine (from 51.48 ± 6.98μM to 118.25 ± 28.63μM) increasing in serum and with abnormally micromorphological changes in kidney. The amount of BUN and creatinine distributed in intestinal tract was positively correlated with those in blood. In impaired renal function rats, the amount of BUN (from 4.26 ± 0.21μMole to 10.72 ± 0.55μMole) and creatinine (from 681.4 ± 23.3 nMole to 928.7 ± 21.3 nMole) distributed in intestinal tract significantly increased. All the results proved that intestinal tract had excretory function compensative for renal function.
authors.affiliation: Kunming Key Laboratory of Molecular Biology for Sinomedicine, Faculty of Basic Medicine, Yunnan University of Traditional Chinese Medicine, Kunming 650500, China; School of Basic Medicine, Kunming Medical University, Kunming 650500, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Yun
authors.affiliation: Kunming Key Laboratory of Molecular Biology for Sinomedicine, Faculty of Basic Medicine, Yunnan University of Traditional Chinese Medicine, Kunming 650500, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Gao
authors.affiliation: Kunming Key Laboratory of Molecular Biology for Sinomedicine, Faculty of Basic Medicine, Yunnan University of Traditional Chinese Medicine, Kunming 650500, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Li
authors.affiliation: Kunming Key Laboratory of Molecular Biology for Sinomedicine, Faculty of Basic Medicine, Yunnan University of Traditional Chinese Medicine, Kunming 650500, China.
authors.forename: Zhiyi
authors.initials: Z
authors.lastname: Gao
authors.affiliation: Kunming Key Laboratory of Molecular Biology for Sinomedicine, Faculty of Basic Medicine, Yunnan University of Traditional Chinese Medicine, Kunming 650500, China.
authors.forename: Jinlian
authors.initials: J
authors.lastname: Duan
authors.affiliation: Kunming Key Laboratory of Molecular Biology for Sinomedicine, Faculty of Basic Medicine, Yunnan University of Traditional Chinese Medicine, Kunming 650500, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Yin
authors.affiliation: Kunming Key Laboratory of Molecular Biology for Sinomedicine, Faculty of Basic Medicine, Yunnan University of Traditional Chinese Medicine, Kunming 650500, China.
authors.forename: Weigang
authors.identifier: 0000-0002-9006-861X
authors.initials: W
authors.lastname: Duan
mesh_terms: D000225:Adenine; D000818:Animals; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D007422:Intestines / Q000502:physiology*; D007674:Kidney Diseases / Q000139:chemically induced / Q000503:physiopathology*; D051381:Rats; D014527:Uric Acid / Q000097:blood
chemical_list: D014527:Uric Acid; D003404:Creatinine; D000225:Adenine