title: Alkaloids from aerial parts of Annona senegalensis against Streptococcus mutans.
abstract: Antimicrobial potential of medicinal plants have been explored extensively these days. This study was carried out to evaluate the antibacterial potential from aerial parts of plant, called 'Annona senegalensis' and its constituents. Bioassay guided fractionation led to the isolation of four metabolites, (+)-catechin (1), (-)-anonaine (2), (-)-asimilobine (3) and (+)-nornantenine (4). This is the first report on the isolation of compounds 1, 3 and 4 from this plant. Compounds 2 and 4 showed good activity, whereas 1 and 3 displayed weak inhibition against Streptococcus mutans (ATCC 25175). The results showed that compound 2 and 3 showed significant activity with a minimum inhibition concentration (MIC) of 0.12 and 0.25 mg/mL, respectively. The present study reports for the first time the antibacterial activity of the extract of A. senegalensis and its constituents. As S. mutans is a rather resistant bacteria, the MIC obtained during the present study is significant.
authors.affiliation: a Department of Plant and soil Sciences, Plant Sciences Complex , University of Pretoria , Pretoria , South Africa.
authors.forename: N
authors.initials: N
authors.lastname: Lall
authors.affiliation: a Department of Plant and soil Sciences, Plant Sciences Complex , University of Pretoria , Pretoria , South Africa.
authors.forename: N
authors.initials: N
authors.lastname: Kishore
authors.affiliation: a Department of Plant and soil Sciences, Plant Sciences Complex , University of Pretoria , Pretoria , South Africa.
authors.forename: D
authors.initials: D
authors.lastname: Bodiba
authors.affiliation: a Department of Plant and soil Sciences, Plant Sciences Complex , University of Pretoria , Pretoria , South Africa.
authors.forename: G
authors.initials: G
authors.lastname: More
authors.affiliation: a Department of Plant and soil Sciences, Plant Sciences Complex , University of Pretoria , Pretoria , South Africa.
authors.forename: E
authors.initials: E
authors.lastname: Tshikalange
authors.affiliation: a Department of Plant and soil Sciences, Plant Sciences Complex , University of Pretoria , Pretoria , South Africa.|b Graduate School of Pharmaceutical Sciences , Tohoku University , Aoba-ku, Sendai , Japan.
authors.forename: H
authors.initials: H
authors.lastname: Kikuchi
authors.affiliation: a Department of Plant and soil Sciences, Plant Sciences Complex , University of Pretoria , Pretoria , South Africa.|b Graduate School of Pharmaceutical Sciences , Tohoku University , Aoba-ku, Sendai , Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Oshima
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000494:pharmacology*; D031041:Annona / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001060:Aporphines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002392:Catechin / Q000737:chemistry / Q000302:isolation & purification; D004149:Dioxoles / Q000737:chemistry / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry; D013295:Streptococcus mutans / Q000187:drug effects*
chemical_list: D000470:Alkaloids; D000900:Anti-Bacterial Agents; D001060:Aporphines; D004149:Dioxoles; D010936:Plant Extracts; C098138:anonaine; C054614:asimilobine; D002392:Catechin; C041615:nantenine
keywords: Annona senegalensis; Streptococcus mutans (ATCC 25175); alkaloids; antibacterial activity; flavonoids