title: An intensive lifestyle intervention reduces circulating oxidised low-density lipoprotein and increases human paraoxonase activity in obese subjects.
abstract: Obesity has a great impact on cardiovascular morbidity and mortality, the treatment of this pathological state is important given the significant health consequences. Lifestyle and behaviour changes play a significant role in weight management. The purpose of this study was to investigate the impact of an intensive multidisciplinary lifestyle intervention on well-known atherogenic factors in a group of overweight and obese subjects.
  
  
  
  A total of 44 people with overweight/obesity underwent a lifestyle intervention based on nutritional education, psychological support and a 3-month exercise training program with a frequency of twice a week. Several anthropometric and biochemical parameters were measured before and after the lifestyle intervention.
  
  
  
  Lifestyle intervention led to a significant reduction in metabolic profile including body mass index (BMI), waist circumference, systolic and diastolic blood pressure, plasma glucose, and plasma triglycerides. These reductions were also accompanied by a significant increase in maximal oxygen consumption and muscle strength. Furthermore, paraoxonase and lactonase activities and the concentration of Apoliproteins A1 (APO A1) were significantly increased and the serum levels of oxLDL reduced without any changes in the circulating levels of LDL and HDL.
  
  
  
  In conclusion, our study suggests that an intensive lifestyle intervention in obese subjects promotes a series of beneficial antiatherogenic changes which included increased enzyme activites of paraoxonase and lactonase, concentration of Apoliproteins A1 and decreased circulating levels of oxLDL.
authors.affiliation: Healthy Lifestyle Institute CURIAMO, Department of Medicine, University of Perugia, Polo Didattico Sant'Andrea delle Fratte, Piazzale Gambuli, 06132 Perugia, Italy. Electronic address: angru@live.it.
authors.forename: Angelo
authors.initials: A
authors.lastname: Russo
authors.affiliation: Department of Experimental Medicine, University of Perugia, Polo Didattico Sant'Andrea delle Fratte, Piazzale Gambuli, 06132 Perugia, Italy. Electronic address: irene.pirisinu@gmail.com.
authors.forename: Irene
authors.initials: I
authors.lastname: Pirisinu
authors.affiliation: Department of Experimental Medicine, University of Perugia, Polo Didattico Sant'Andrea delle Fratte, Piazzale Gambuli, 06132 Perugia, Italy. Electronic address: carmine.vacca@unipg.it.
authors.forename: Carmine
authors.initials: C
authors.lastname: Vacca
authors.affiliation: Healthy Lifestyle Institute CURIAMO, Department of Medicine, University of Perugia, Polo Didattico Sant'Andrea delle Fratte, Piazzale Gambuli, 06132 Perugia, Italy. Electronic address: elisa.reginato@gmail.com.
authors.forename: Elisa
authors.initials: E
authors.lastname: Reginato
authors.affiliation: Healthy Lifestyle Institute CURIAMO, Department of Medicine, University of Perugia, Polo Didattico Sant'Andrea delle Fratte, Piazzale Gambuli, 06132 Perugia, Italy. Electronic address: emilia.sbroma@virgilio.it.
authors.forename: Emilia Sbroma
authors.initials: ES
authors.lastname: Tomaro
authors.affiliation: Healthy Lifestyle Institute CURIAMO, Department of Medicine, University of Perugia, Polo Didattico Sant'Andrea delle Fratte, Piazzale Gambuli, 06132 Perugia, Italy. Electronic address: robertopippi@gmail.com.
authors.forename: Roberto
authors.initials: R
authors.lastname: Pippi
authors.affiliation: Healthy Lifestyle Institute CURIAMO, Department of Medicine, University of Perugia, Polo Didattico Sant'Andrea delle Fratte, Piazzale Gambuli, 06132 Perugia, Italy. Electronic address: cristina.aiello@hotmail.com.
authors.forename: Cristina
authors.initials: C
authors.lastname: Aiello
authors.affiliation: Department of Experimental Medicine, University of Perugia, Polo Didattico Sant'Andrea delle Fratte, Piazzale Gambuli, 06132 Perugia, Italy. Electronic address: vincenzo.talesa@unipg.it.
authors.forename: Vincenzo Nicola
authors.initials: VN
authors.lastname: Talesa
authors.affiliation: Healthy Lifestyle Institute CURIAMO, Department of Medicine, University of Perugia, Polo Didattico Sant'Andrea delle Fratte, Piazzale Gambuli, 06132 Perugia, Italy. Electronic address: pierpaolodefeo@gmail.com.
authors.forename: Pierpaolo
authors.initials: P
authors.lastname: De Feo
authors.affiliation: Department of Experimental Medicine, University of Perugia, Polo Didattico Sant'Andrea delle Fratte, Piazzale Gambuli, 06132 Perugia, Italy. Electronic address: rita.romani@unipg.it.
authors.forename: Rita
authors.initials: R
authors.lastname: Romani
mesh_terms: D043303:Aryldialkylphosphatase / Q000378:metabolism*; D015992:Body Mass Index; D003131:Combined Modality Therapy; D004038:Diet, Reducing; D015444:Exercise; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000201:enzymology* / Q000517:prevention & control; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000150:complications / Q000201:enzymology* / Q000517:prevention & control; D040242:Risk Reduction Behavior; D016896:Treatment Outcome; D015431:Weight Loss / Q000502:physiology; D061217:Weight Reduction Programs
chemical_list: D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein; D043303:Aryldialkylphosphatase
keywords: Exercise; Obesity; Overweight; PON activity; oxLDL