title: Retinal vascular caliber associated with cardiac and renal target organ damage in never-treated hypertensive patients.
abstract: The aim of this study was to assess the relationship between retinal vascular caliber and target organ damage in HT patients.
  
  
  
  Data were collected on cardiac, renal, vascular, and retinal variables in 88 consecutive never-treated HT subjects. Retinal vascular calibers were measured from fundus photographs by using a semi-automated computer-assisted program and summarized as CRAE and CRVE.
  
  
  
  Mean CRAE and CRVE were significantly lower in patients with left ventricular hypertrophy (left ventricular mass ≥110 g/m² for women, 125 g/m² for men) than in those with normal left ventricular (CRAE: 129.4±3.7 vs 138.2±2.3 μm; P=.04; CRVE: 195.6±4.4 vs 209.8±2.7 μm; P=.008). CRAE and CRVE were negatively correlated with urinary albumin excretion (β±SE=-15.4±3.2, P<.0001 and β±SE=-11.9±4.4, P=.001, respectively) but were not correlated with estimated glomerular filtration rate (P=.21 and P=.75, respectively), carotid-to-femoral pulse wave velocity (P=.24 and P=.14), or carotid augmentation index (P=.43 and P=.16).
  
  
  
  In never-treated HT patients, reduced CRAE and CRVE were associated with cardiac and renal preclinical damage, ie, left ventricular hypertrophy and albuminuria, but not estimated glomerular filtration rate or vascular stiffness.
authors.affiliation: Department of Opthalmology, Hôpital Gui de Chauliac, Montpellier, France.|Université Montpellier 1, Montpellier, France.|National Institute for Health and Medical Research (INSERM), U1061, Montpellier, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Daien
authors.affiliation: Department of Opthalmology, Hôpital Gui de Chauliac, Montpellier, France.|Université Montpellier 1, Montpellier, France.
authors.forename: Loic
authors.initials: L
authors.lastname: Granados
authors.affiliation: Department of Public Health, Yamagata University Graduate School of Medical Science, Yamagata, Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Kawasaki
authors.affiliation: Department of Opthalmology, Hôpital Gui de Chauliac, Montpellier, France.|Université Montpellier 1, Montpellier, France.
authors.forename: Max
authors.initials: M
authors.lastname: Villain
authors.affiliation: Université Montpellier 1, Montpellier, France.|Department of Internal Medicine, Hôpital Lapeyronie, Montpellier, France.
authors.forename: Jean
authors.initials: J
authors.lastname: Ribstein
authors.affiliation: Department of Internal Medicine, Hôpital Lapeyronie, Montpellier, France.
authors.forename: Guilhem
authors.initials: G
authors.lastname: Du Cailar
authors.affiliation: Department of Internal Medicine, Hôpital Lapeyronie, Montpellier, France.
authors.forename: Albert
authors.initials: A
authors.lastname: Mimran
authors.affiliation: Université Montpellier 1, Montpellier, France.|Department of Internal Medicine, Hôpital Lapeyronie, Montpellier, France.|PhyMedExp, INSERM U1046, CNRS UMR 9214, University of Montpellier 34295 Montpellier Cedex 5, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Fesler
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000419:Albuminuria / Q000473:pathology; D003430:Cross-Sectional Studies; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D017379:Hypertrophy, Left Ventricular / Q000473:pathology; D007091:Image Processing, Computer-Assisted; D007668:Kidney / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology; D011446:Prospective Studies; D012171:Retinal Vessels / Q000473:pathology* / Q000503:physiopathology; D059289:Vascular Stiffness
keywords: hypertension; microcirculation; retinal vessels; target organ damages