title: Endocytosis, Metastasis and Beyond: Multiple Facets of SNX9.
abstract: Sorting nexin (SNX)9 was first discovered as an endocytic accessory protein involved in clathrin-mediated endocytosis. However, recent data suggest that SNX9 is a multifunctional scaffold that coordinates membrane trafficking and remodeling with changes in actin dynamics to affect diverse cellular processes. Here, we review the accumulated knowledge on SNX9 with an emphasis on its recently identified roles in clathrin-independent endocytic pathways, cell invasion, and cell division, which have implications for SNX9 function in human disease, including cancer.
authors.affiliation: Department of Cell Biology, The University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address: nb141@alumni.utsw.edu.
authors.forename: Nawal
authors.initials: N
authors.lastname: Bendris
authors.affiliation: Department of Cell Biology, The University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address: sandra.schmid@utsouthwestern.edu.
authors.forename: Sandra L
authors.initials: SL
authors.lastname: Schmid
mesh_terms: D000818:Animals; D002455:Cell Division; D002465:Cell Movement; D004194:Disease; D004705:Endocytosis; D006801:Humans; D009362:Neoplasm Metastasis / Q000473:pathology*; D058305:Sorting Nexins / Q000737:chemistry / Q000378:metabolism*
chemical_list: D058305:Sorting Nexins
keywords: RhoGTPase; actin; cancer; cell motility; inflammation; invadosome; mitosis