title: CD40 signaling and hepatic steatosis: Unanticipated links.
abstract: Obesity predisposes to an increased risk of nonalcoholic fatty liver disease (NAFLD). Hepatic steatosis is the key pathological feature of NAFLD and has emerged as a metabolic disorder in which innate and adaptive arms of the immune response play a central role in disease pathogenesis. Recent studies have revealed unexpected relationships between CD40 signaling and hepatic steatosis in high fat diet rodent models. CD154, the ligand of CD40, is a mediator of inflammation and controls several critical events of innate and adaptive immune responses. In the light of these reports, we discuss potential links between CD40 signaling and hepatic steatosis in NAFLD.
authors.affiliation: INSERM U1026, Université de Bordeaux, 33000 Bordeaux, France.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Lepreux
authors.affiliation: Cell and Developmental Biology Programme, Centre for Genomic Regulation, 08003 Barcelona, Spain.
authors.forename: Julien
authors.initials: J
authors.lastname: Villeneuve
authors.affiliation: Service d'Anesthésie-Réanimation II, CHU de Bordeaux, 33600 Pessac, France.
authors.forename: Antoine
authors.initials: A
authors.lastname: Dewitte
authors.affiliation: Service de Biochimie, CHU de Bordeaux, 33000 Bordeaux, France.
authors.forename: Annie M
authors.initials: AM
authors.lastname: Bérard
authors.affiliation: EA 6309, Université de Limoges, 87000 Limoges, France.
authors.forename: Alexis
authors.initials: A
authors.lastname: Desmoulière
authors.affiliation: INSERM U1026, Université de Bordeaux, 33000 Bordeaux, France. Electronic address: jean.ripoche@u-bordeaux.fr.
authors.forename: Jean
authors.initials: J
authors.lastname: Ripoche
mesh_terms: D019013:CD40 Antigens / Q000502:physiology*; D006801:Humans; D065626:Non-alcoholic Fatty Liver Disease / Q000209:etiology*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D019013:CD40 Antigens