title: REM sleep behaviour disorder: prodromal and mechanistic insights for Parkinson's disease.
abstract: Rapid eye movement (REM) sleep behaviour disorder (RBD) is characterised by complex motor enactment of dreams and is a potential prodromal marker of Parkinson's disease (PD). Of note, patients with PD observed during RBD episodes exhibit improved motor function, relative to baseline states during wake periods. Here, we review recent epidemiological and mechanistic findings supporting the prodromal value of RBD for PD, incorporating clinical and electrophysiological studies. Explanations for the improved motor function during RBD episodes are evaluated in light of recent publications. In addition, we present preliminary findings describing changes in the activity of the basal ganglia across the sleep-wake cycle that contribute to our understanding of RBD.
authors.affiliation: Department of Neurosurgery, University of Colorado-Anschutz Medical Center, Denver, Colorado, USA.
authors.forename: Anand
authors.initials: A
authors.lastname: Tekriwal
authors.affiliation: Department of Neurology, University of Colorado-Anschutz Medical Center, Denver, Colorado, USA.
authors.forename: Drew S
authors.initials: DS
authors.lastname: Kern
authors.affiliation: Department of Neurology, University of Colorado-Anschutz Medical Center, Denver, Colorado, USA.
authors.forename: Jean
authors.initials: J
authors.lastname: Tsai
authors.affiliation: Biomedical Engineering, University of Houston, Houston, Texas, USA.
authors.forename: Nuri F
authors.initials: NF
authors.lastname: Ince
authors.affiliation: Neuromodulation Global Research, Medtronic, Minneapolis, Minnesota, USA.
authors.forename: Jianping
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Neurosurgery, University of Colorado-Anschutz Medical Center, Denver, Colorado, USA.
authors.forename: John A
authors.identifier: 0000-0003-2991-5194
authors.initials: JA
authors.lastname: Thompson
authors.affiliation: Department of Neurosurgery, University of Colorado-Anschutz Medical Center, Denver, Colorado, USA.
authors.forename: Aviva
authors.initials: A
authors.lastname: Abosch
mesh_terms: D004325:Dreams / Q000523:psychology; D006801:Humans; D010300:Parkinson Disease / Q000453:epidemiology*; D017286:Polysomnography / Q000379:methods; D020187:REM Sleep Behavior Disorder / Q000175:diagnosis / Q000453:epidemiology*; D012720:Severity of Illness Index
keywords: EMG; MOTOR CONTROL; MULTISYSTEM ATROPHY; PARKINSON'S DISEASE; SLEEP DISORDERS