title: Successful treatment of mature B-cell lymphoma with rituximab-based chemotherapy in a patient with Bloom syndrome.
abstract: This report presents a case of Bloom syndrome (BS) in a consanguineous Saudi family. The patient, an 11-year-old male with mature B-cell lymphoma, had minimal therapeutic response and significant dose-limiting toxicity with standard chemotherapy treatment. He later responded successfully to a rituximab-based chemotherapy protocol. This case highlights that the rituximab-based chemotherapy protocol is an effective and safe treatment alternative for mature B-cell lymphoma in patients with BS. Further trials are warranted to investigate this modality of treatment.
authors.affiliation: College of Medicine, Department of Pediatrics, Umm AlQura University, Makkah, Saudi Arabia.|Princess Noorah Oncology Center, King Abdulaziz Medical City, Jeddah, Saudi Arabia.
authors.forename: Wasil
authors.initials: W
authors.lastname: Jastaniah
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001816:Bloom Syndrome / Q000150:complications*; D002648:Child; D006801:Humans; D016393:Lymphoma, B-Cell / Q000188:drug therapy* / Q000235:genetics*; D008297:Male; D000069283:Rituximab / Q000627:therapeutic use*
chemical_list: D000069283:Rituximab
keywords: B-cell lymphoma; Bloom syndrome; chemotherapy; rituximab