title: Impact on quality of life of alitretinoin in severe chronic hand eczema: FUGETTA real-world study.
abstract: OBJECTIVE
  Alitretinoin is the only approved treatment for severe chronic hand eczema (CHE) refractory to potent topical corticosteroids. This study (FUGETTA) evaluated the effectiveness and impact on quality of life (QoL) of oral alitretinoin in patients with severe refractory CHE in accordance with prescription guidelines.
  
  
  METHODS
  Open-label, multicenter, noninterventional, observational study conducted in Germany. Patients were treated at their physician's discretion with once-daily alitretinoin 10 mg or 30 mg for a maximum of 24 weeks. Effectiveness was assessed by Physician Global Assessment (PGA) and Dermatology Life Quality Index (DLQI). Adverse events (AEs) were assessed.
  
  
  RESULTS
  The study population included 658 patients (30 mg n = 581; 10 mg n = 77). At baseline, most patients had CHE characterized as severe by PGA (83 %). At last visit, 48 % of patients had a PGA response of clear/almost clear (30 mg: 49 %; 10 mg: 43 %). Mean improvement in DLQI scores at week 24 was 58 % (30 mg: mean [SD] change from baseline -10.4 [8.04]) and 70 % (10 mg: mean [SD] change from baseline -10.8 [7.29]). The overall incidence of AEs was low and similar in both groups.
  
  
  CONCLUSIONS
  Alitretinoin produced rapid, marked improvement in QoL of patients with severe CHE.
authors.affiliation: IVDP, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Augustin
authors.affiliation: Comprehensive Center for Inflammation Medicine, University of Luebeck, Germany.
authors.forename: Diamant
authors.initials: D
authors.lastname: Thaçi
authors.affiliation: Stiefel, a GSK company, Munich, Germany.
authors.forename: Anja
authors.initials: A
authors.lastname: Kamps
mesh_terms: D000279:Administration, Cutaneous; D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000077556:Alitretinoin; D002908:Chronic Disease; D003879:Dermatologic Agents / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D004485:Eczema / Q000188:drug therapy* / Q000453:epidemiology / Q000523:psychology*; D005260:Female; D005858:Germany / Q000453:epidemiology; D006229:Hand Dermatoses / Q000188:drug therapy* / Q000453:epidemiology / Q000523:psychology*; D006801:Humans; D008875:Middle Aged; D017060:Patient Satisfaction / Q000706:statistics & numerical data*; D015995:Prevalence; D011788:Quality of Life / Q000523:psychology*; D012720:Severity of Illness Index; D017678:Sex Distribution; D016896:Treatment Outcome; D014212:Tretinoin / Q000008:administration & dosage*; D016387:Women's Health / Q000706:statistics & numerical data; D055815:Young Adult
chemical_list: D003879:Dermatologic Agents; D000077556:Alitretinoin; D014212:Tretinoin