title: Tolerance in Kidney Transplantation: What Is on the B Side?
abstract: Regulatory B cells (Breg) are in the spotlight for their role in immune homeostasis maintenance and tolerance achievement as in the last years the correlation with functional and increased Breg numbers in autoimmune diseases and transplantation has been extensively proven. Their study is, however, in its infancy with still little knowledge and consensus on their origin, phenotype, and mechanism of action. All this hampers the pursuit of an effective Breg induction method for therapeutic purposes. In this review we aim to summarize the studies on human Breg and their implication in kidney transplantation and to further discuss the issues surrounding therapeutic applications of this cell subset.
authors.affiliation: REMAR-IVECAT Group, Health Science Research Institute Germans Trias i Pujol, Can Ruti Campus, Badalona, Spain.
authors.forename: Laura
authors.identifier: 0000-0003-3512-0849
authors.initials: L
authors.lastname: Carreras-Planella
authors.affiliation: REMAR-IVECAT Group, Health Science Research Institute Germans Trias i Pujol, Can Ruti Campus, Badalona, Spain.
authors.forename: Francesc E
authors.initials: FE
authors.lastname: Borràs
authors.affiliation: REMAR-IVECAT Group, Health Science Research Institute Germans Trias i Pujol, Can Ruti Campus, Badalona, Spain.
authors.forename: Marcella
authors.identifier: 0000-0002-1287-8908
authors.initials: M
authors.lastname: Franquesa
mesh_terms: D000818:Animals; D060151:B-Lymphocytes, Regulatory / Q000276:immunology*; D015415:Biomarkers / Q000378:metabolism; D006085:Graft Survival; D006801:Humans; D007108:Immune Tolerance; D016753:Interleukin-10 / Q000378:metabolism; D007676:Kidney Failure, Chronic / Q000276:immunology* / Q000601:surgery*; D016030:Kidney Transplantation; D051379:Mice; D010641:Phenotype
chemical_list: D015415:Biomarkers; C508609:IL10 protein, human; D016753:Interleukin-10