title: TLR10 Is a B Cell Intrinsic Suppressor of Adaptive Immune Responses.
abstract: Toll-like receptors play a central role in the initiation of adaptive immune responses with several TLR agonists acting as known B cell mitogens. Despite thousands of publications on TLRs, the function of TLR10 remains unknown. We have found that Ab-mediated engagement of TLR10 on primary human B cells suppresses B cell proliferation, cytokine production, and signal transduction. When challenged with either a T independent or T dependent Ag, TLR10 transgenic mice exhibit diminished Ab responses. Adoptive transfer of splenic B cells into B cell-deficient mice revealed that the suppressive effects on Ag-specific humoral immune responses are entirely B cell intrinsic. Our results demonstrate that TLR10 has a functional role within the B cell lineage that is distinct from that of other TLR family members and may provide a potential therapeutic target for diseases characterized by dysregulated B cell activity.
authors.affiliation: Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801; and.
authors.forename: Nicholas J
authors.identifier: 0000-0001-5720-9305
authors.initials: NJ
authors.lastname: Hess
authors.affiliation: Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801; and.|College of Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
authors.forename: Song
authors.identifier: 0000-0003-4890-4327
authors.initials: S
authors.lastname: Jiang
authors.affiliation: Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801; and.
authors.forename: Xinyan
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801; and.
authors.forename: Yue
authors.initials: Y
authors.lastname: Guan
authors.affiliation: Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801; and tapping@illinois.edu.|College of Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
authors.forename: Richard I
authors.initials: RI
authors.lastname: Tapping
mesh_terms: D056704:Adaptive Immunity / Q000276:immunology*; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005434:Flow Cytometry; D055879:Gene Knock-In Techniques; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology*; D051379:Mice; D008822:Mice, Transgenic; D020133:Reverse Transcriptase Polymerase Chain Reaction; D051201:Toll-Like Receptor 10 / Q000276:immunology*
chemical_list: D051201:Toll-Like Receptor 10