title: Identification of cancer risk lncRNAs and cancer risk pathways regulated by cancer risk lncRNAs based on genome sequencing data in human cancers.
abstract: Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. The complexity of cancer can be reduced to a small number of underlying principles like cancer hallmarks which could govern the transformation of normal cells to cancer. Besides, the growth and metastasis of cancer often relate to combined effects of long non-coding RNAs (lncRNAs). Here, we performed comprehensive analysis for lncRNA expression profiles and clinical data of six types of human cancer patients from The Cancer Genome Atlas (TCGA), and identified six risk pathways and twenty three lncRNAs. In addition, twenty three cancer risk lncRNAs which were closely related to the occurrence or development of cancer had a good classification performance for samples of testing datasets of six cancer datasets. More important, these lncRNAs were able to separate samples in the entire cancer dataset into high-risk group and low-risk group with significantly different overall survival (OS), which was further validated in ten validation datasets. In our study, the robust and effective cancer biomarkers were obtained from cancer datasets which had information of normal-tumor samples. Overall, our research can provide a new perspective for the further study of clinical diagnosis and treatment of cancer.
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Hei Longjiang Province, Postal code: 150081, China.
authors.forename: Yiran
authors.initials: Y
authors.lastname: Li
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Hei Longjiang Province, Postal code: 150081, China.
authors.forename: Wan
authors.initials: W
authors.lastname: Li
authors.affiliation: National Microbology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.
authors.forename: Binhua
authors.initials: B
authors.lastname: Liang
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Hei Longjiang Province, Postal code: 150081, China.
authors.forename: Liansheng
authors.initials: L
authors.lastname: Li
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Hei Longjiang Province, Postal code: 150081, China.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Hei Longjiang Province, Postal code: 150081, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Huang
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Hei Longjiang Province, Postal code: 150081, China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Guo
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Hei Longjiang Province, Postal code: 150081, China.
authors.forename: Yahui
authors.initials: Y
authors.lastname: Wang
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Hei Longjiang Province, Postal code: 150081, China.
authors.forename: Yuehan
authors.initials: Y
authors.lastname: He
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Hei Longjiang Province, Postal code: 150081, China.
authors.forename: Lina
authors.initials: L
authors.lastname: Chen
authors.affiliation: Institute of Opto-electronics, Harbin Institute of Technology, Harbin, Heilongjiang Province, Postal code: 150081, China.
authors.forename: Weiming
authors.initials: W
authors.lastname: He
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D006801:Humans; D009369:Neoplasms / Q000401:mortality* / Q000473:pathology*; D062085:RNA, Long Noncoding / Q000032:analysis*; D018570:Risk Assessment; D016019:Survival Analysis
chemical_list: D014408:Biomarkers, Tumor; D062085:RNA, Long Noncoding