title: A One-Pot Synthesis of 2-Aminopyrimidines from Ketones, Arylacetylenes, and Guanidine.
abstract: The three-component reaction of ketones, arylacetylenes, and guanidine catalyzed by the KOBut/DMSO system leads to 2-aminopyrimidines in up to 80% yield. Depending on structure of the starting ketones, the aromatization of intermediate dihydropyrimidines occurs either with loss of hydrogen molecules or methylbenzenes. The latter process takes place in the ketones, in which one of the substituents is not a methyl group. The reaction conditions are tolerable for dialkyl-, aryl(hetaryl) alkyl-, and cycloalkyl ketones.
authors.affiliation: A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences , 1 Favorsky Str., Irkutsk 664033, Russia.
authors.forename: Elena Yu
authors.initials: EY
authors.lastname: Schmidt
authors.affiliation: A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences , 1 Favorsky Str., Irkutsk 664033, Russia.
authors.forename: Inna V
authors.initials: IV
authors.lastname: Tatarinova
authors.affiliation: A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences , 1 Favorsky Str., Irkutsk 664033, Russia.
authors.forename: Nadezhda I
authors.initials: NI
authors.lastname: Protsuk
authors.affiliation: A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences , 1 Favorsky Str., Irkutsk 664033, Russia.
authors.forename: Igor' A
authors.initials: IA
authors.lastname: Ushakov
authors.affiliation: A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences , 1 Favorsky Str., Irkutsk 664033, Russia.
authors.forename: Boris A
authors.identifier: 0000-0002-0430-3215
authors.initials: BA
authors.lastname: Trofimov