title: Evaluation of hepatoprotective and antidiabetic activity of Alchemilla mollis.
abstract: Alchemilla mollis (Buser) Rothm aerial part and root methanolic-water extracts were evaluated for their hepatoprotective activity on carbon tetrachloride induced hepatotoxicity and hypoglycemic activity on alloxan-induced diabetic mice. None of the tested extracts exhibited effects on blood glucose levels. However hepatoprotective activity results have revealed that serum ALT levels were significantly lowered by both the aerial part and root extracts at doses of 100mg/kg and 200mg/kg. Histopathological examination showed that A. mollis aerial parts and roots induced significant recovery from cellular damage; when compared to the carbon tetrachloride group, the most significant activity was observed with A. mollis aerial part extracts at a dose of 200mg/kg. There is evidence of a hepatoprotective activity of A. mollis on the phenolic content of the plant, especially in the case of flavonoids, which have potent antioxidant properties.
authors.affiliation: Istanbul Medipol University, Faculty of Medicine, Department of Pharmacology, Istanbul, Turkey.
authors.forename: Hanefi
authors.initials: H
authors.lastname: Ozbek
authors.affiliation: Ankara University, Faculty of Pharmacy, Department of Pharmacognosy, Ankara, Turkey.
authors.forename: Ozlem Bahadir
authors.initials: OB
authors.lastname: Acikara
authors.affiliation: Istanbul Medipol University, Faculty of Medicine, Department of Histology and Embryology, Istanbul, Turkey.
authors.forename: Ilknur
authors.initials: I
authors.lastname: Keskin
authors.affiliation: Istanbul Medipol University, Faculty of Medicine, Department of Vocational School of Health Services Istanbul, Turkey. Electronic address: nikirmizi@medipol.edu.tr.
authors.forename: Neriman Ipek
authors.initials: NI
authors.lastname: Kirmizi
authors.affiliation: Ankara University, Faculty of Pharmacy, Department of Pharmacognosy, Ankara, Turkey.
authors.forename: Serkan
authors.initials: S
authors.lastname: Ozbilgin
authors.affiliation: Ankara University, Faculty of Pharmacy, Department of Pharmacognosy, Ankara, Turkey.
authors.forename: Burcin Ergene
authors.initials: BE
authors.lastname: Oz
authors.affiliation: Ankara University, Faculty of Pharmacy, Department of Pharmacognosy, Ankara, Turkey.
authors.forename: Ekin
authors.initials: E
authors.lastname: Kurtul
authors.affiliation: Istanbul Medipol University, Faculty of Medicine, Department of Vocational School of Health Services Istanbul, Turkey.
authors.forename: Bade Cevriye
authors.initials: BC
authors.lastname: Ozrenk
authors.affiliation: Cumhuriyet University, Faculty of Pharmacy, Department of Pharmaceutical Botany, Sivas, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Tekin
authors.affiliation: Ankara University, Faculty of Pharmacy, Department of Pharmacognosy, Ankara, Turkey.
authors.forename: Gulcin
authors.initials: G
authors.lastname: Saltan
mesh_terms: D031982:Alchemilla; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000473:pathology; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005260:Female; D007004:Hypoglycemic Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008297:Male; D051379:Mice; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D018517:Plant Roots; D020011:Protective Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D007004:Hypoglycemic Agents; D010936:Plant Extracts; D020011:Protective Agents
keywords: Alchemilla mollis; Antidiabetic activity; Hepatoprotective activity; Mice; Rats