title: siRNA carrying an (E)-vinylphosphonate moiety at the 5΄ end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2.
authors.affiliation: Keck Structural Biology Lab, Cold Spring Harbor, NY 11724, USA.|Howard Hughes Medical Institute, Cold Spring Harbor, NY 11724, USA.|Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
authors.forename: Elad
authors.initials: E
authors.lastname: Elkayam
authors.affiliation: Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA 02142, USA.
authors.forename: Rubina
authors.initials: R
authors.lastname: Parmar
authors.affiliation: Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA 02142, USA.
authors.forename: Christopher R
authors.initials: CR
authors.lastname: Brown
authors.affiliation: Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA 02142, USA.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Willoughby
authors.affiliation: Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA 02142, USA.
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Theile
authors.affiliation: Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA 02142, USA.
authors.forename: Muthiah
authors.initials: M
authors.lastname: Manoharan
authors.affiliation: Keck Structural Biology Lab, Cold Spring Harbor, NY 11724, USA.|Howard Hughes Medical Institute, Cold Spring Harbor, NY 11724, USA.|Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
authors.forename: Leemor
authors.initials: L
authors.lastname: Joshua-Tor