title: Copper-Catalyzed Radical-Promoted Aminocyclization of Acrylamides with N-Fluorobenzenesulfonimide.
abstract: A facile copper-catalyzed radical aminoarylation of acrylamide with N-fluorobenzenesulfonimide (NFSI) is described. In the presence of copper acetate and 1,10-phenanthroline, a range of isoquinoline-1,3-diones can be constructed in moderate to good yields using NFSI as the amination reagent. Mechanistic studies demonstrated the reaction went through a sequential radical addition and cyclization pathway, which was supported by DFT calculations.
authors.affiliation: The Key Laboratory of Food Colloids and Biotechnology, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University , Wuxi, Jiangsu 214122, China.
authors.forename: Xiao-Feng
authors.identifier: 0000-0002-1837-0638
authors.initials: XF
authors.lastname: Xia
authors.affiliation: The Key Laboratory of Food Colloids and Biotechnology, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University , Wuxi, Jiangsu 214122, China.
authors.forename: Su-Li
authors.initials: SL
authors.lastname: Zhu
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University , Jinan 250014, P. R. China.
authors.forename: Jian-Biao
authors.initials: JB
authors.lastname: Liu
authors.affiliation: The Key Laboratory of Food Colloids and Biotechnology, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University , Wuxi, Jiangsu 214122, China.
authors.forename: Dawei
authors.initials: D
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou 730000, China.
authors.forename: Yong-Min
authors.initials: YM
authors.lastname: Liang