title: Association betweenCHFRgene hypermethylation and gastric cancer risk: a meta-analysis.
abstract: BACKGROUND
  The association between the hypermethylation ofCHFRgene and gastric cancer risk has been investigated by a number of studies. However, the sample size of the majority of these studies was very small. To get a more a convincing conclusion, here we performed a meta-analysis of the previously published studies to assess the association betweenCHFRmethylation and the risk of gastric cancer.
  
  
  METHODS
  Eligible studies were identified by searching the MEDLINE/PubMed, Embase, and Web of Science databases before May 2016 without any language restriction. The strength of the association was estimated by odds ratio with its 95% confidence interval (CI).
  
  
  RESULTS
  Totally 1,399 samples, including 758 gastric cancer cases and 641 controls, from 13 studies were included in the present meta-analysis. Compared with non-cancer controls, the pooled OR ofCHFRmethylation in gastric cancer patients was 9.08 (95% CI: 6.40-12.88,P<0.001), suggesting that the methylation ofCHFRwas significantly associated with increased risk of gastric cancer. Similar results were observed when subgroup analyses were performed stratified by country, ethnicity, and methylation testing methods.
  
  
  CONCLUSIONS
  Our meta-analysis showed a strong positive correlation betweenCHFRmethylation and risk of gastric cancer, suggesting thatCHFRmethylation might be a promising biomarker for the diagnosis of gastric cancer.
authors.affiliation: Department of Gastroenterology, Lishui Central Hospital, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui Hospital of Zhejiang University, Lishui, People's Republic of China.
authors.forename: Hua
authors.initials: H
authors.lastname: Shi
authors.affiliation: Department of Gastroenterology, Lishui Central Hospital, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui Hospital of Zhejiang University, Lishui, People's Republic of China.
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Gastroenterology, Lishui Central Hospital, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui Hospital of Zhejiang University, Lishui, People's Republic of China.
authors.forename: Jianbo
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Gastroenterology, Lishui Central Hospital, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui Hospital of Zhejiang University, Lishui, People's Republic of China.
authors.forename: Jundi
authors.initials: J
authors.lastname: Pan
authors.affiliation: Department of Gastroenterology, Lishui Central Hospital, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui Hospital of Zhejiang University, Lishui, People's Republic of China.
authors.forename: Junwei
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Gastroenterology, Lishui Central Hospital, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui Hospital of Zhejiang University, Lishui, People's Republic of China.
authors.forename: Bin
authors.initials: B
authors.lastname: Ye
keywords: CHFR; gastric cancer; methylation; risk; tumor suppressor gene