title: The SAMP8 mouse for investigating memory and the role of insulin in the brain.
abstract: SAMP8 mice exhibit changes that commonly occur with normal aging late in life, but do so at a much earlier age. These changes include impairments in learning and memory as early as 8months of age and so the SAMP8 is a useful model to investigate those age-related brain changes that may affect cognition. As brain insulin signaling and memory decline with aging, the SAMP8 model is useful for investigating these changes and interventions that might prevent the decline. This review will summarize the SAMP8 mouse model, highlight changes in brain insulin signaling and its role in memory, and discuss intranasal insulin delivery in investigating effects on insulin metabolism and memory in the SAMP8 mice.
authors.affiliation: Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington School of Medicine, United States. Electronic address: meredime@uw.edu.
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Rhea
authors.affiliation: Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington School of Medicine, United States.
authors.forename: William A
authors.initials: WA
authors.lastname: Banks
mesh_terms: D000367:Age Factors; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism* / Q000503:physiopathology; D003072:Cognition Disorders / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism* / Q000523:psychology; D000066492:Cognitive Aging; D004195:Disease Models, Animal; D005838:Genotype; D006801:Humans; D007328:Insulin / Q000378:metabolism* / Q000627:therapeutic use; D007333:Insulin Resistance; D008568:Memory / Q000187:drug effects; D008569:Memory Disorders / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism* / Q000523:psychology; D008817:Mice, Mutant Strains; D010641:Phenotype; D015398:Signal Transduction
chemical_list: D007328:Insulin
keywords: Insulin; Memory; SAMP8