title: Noninvasive epicardial and endocardial electrocardiographic imaging of scar-related ventricular tachycardia.
abstract: The majority of life-threatening ventricular tachycardias (VTs) are sustained by heterogeneous scar substrates with narrow strands of surviving tissue. An effective treatment for scar-related VT is to modify the underlying scar substrate by catheter ablation. If activation sequence and entrainment mapping can be performed during sustained VT, the exit and isthmus of the circuit can often be identified. However, with invasive catheter mapping, only monomorphic VT that is hemodynamically stable can be mapped in this manner. For the majority of patients with poorly tolerated VTs or multiple VTs, a close inspection of the re-entry circuit is not possible. A noninvasive approach to fast mapping of unstable VTs can potentially allow an improved identification of critical ablation sites.
  
  
  
  For patients who underwent catheter ablation of scar-related VT, CT scan was obtained prior to the ablation procedure and 120-lead body-surface electrocardiograms (ECGs) were acquired during induced VTs. These data were used for noninvasive ECG imaging to computationally reconstruct electrical potentials on the epicardium and on the endocardium of both ventricles. Activation time and phase maps of the VT circuit were extracted from the reconstructed electrograms. They were analyzed with respect to scar substrate obtained from catheter mapping, as well as VT exits confirmed through ablation sites that successfully terminated the VT.
  
  
  
  The reconstructed re-entry circuits correctly revealed both epicardial and endocardial origins of activation, consistent with locations of exit sites confirmed from the ablation procedure. The temporal dynamics of the re-entry circuits, particularly the slowing of conduction as indicated by the crowding and zig-zag conducting of the activation isochrones, collocated well with scar substrate obtained by catheter voltage maps. Furthermore, the results indicated that some re-entry circuits involve both the epicardial and endocardial layers, and can only be properly interpreted by mapping both layers simultaneously.
  
  
  
  This study investigated the potential of ECG-imaging for beat-to-beat mapping of unstable reentrant circuits. It shows that simultaneous epicardial and endocardial mapping may improve the delineation of the 3D spatial construct of a re-entry circuit and its exit. It also shows that the use of phase mapping can reveal regions of slow conduction that collocate well with suspected heterogeneous regions within and around the scar.
authors.affiliation: Rochester Institute of Technology, Rochester, NY, USA. Electronic address: linwei.wang@rit.edu.
authors.forename: Linwei
authors.initials: L
authors.lastname: Wang
authors.affiliation: Rochester Institute of Technology, Rochester, NY, USA.
authors.forename: Omar A
authors.initials: OA
authors.lastname: Gharbia
authors.affiliation: Dalhousie University, Halifax, NS, Canada.
authors.forename: B Milan
authors.initials: BM
authors.lastname: Horáček
authors.affiliation: Dalhousie University, Halifax, NS, Canada.
authors.forename: John L
authors.initials: JL
authors.lastname: Sapp
mesh_terms: D000328:Adult; D000368:Aged; D018780:Body Surface Potential Mapping / Q000379:methods*; D002921:Cicatrix / Q000150:complications / Q000175:diagnosis*; D004562:Electrocardiography / Q000379:methods*; D056149:Epicardial Mapping / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017682:Myocardial Stunning / Q000150:complications / Q000175:diagnosis*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014693:Ventricular Fibrillation / Q000175:diagnosis* / Q000209:etiology
keywords: Catheter ablation; Electrocardiographic imaging; Inverse solution; Phase mapping; Scar-related ventricular tachycardia