title: Prebiotic Effects of Poly-Gamma-Glutamate on Bacterial Flora in Murine Gut.
abstract: Prebiotics improve the growth or activities of specific microbial genera and species in the gut microbiota in order to confer health benefits to the host. In this study, we investigated the effect of poly-gamma-glutamate (γ-PGA) as a prebiotic on the gut microbiota of mice and the organ distributions of γ-PGA in mice. Pyrosequencing analysis for 16S rRNA genes of bacteria indicated that oral administration of γ-PGA increased the abundance of Lactobacillales while reducing the abundance of Clostridiales in murine guts. It is suggested that oral administration of γ-PGA can be helpful for modulating the gut microbiota as a prebiotic.
authors.affiliation: Department of Bio and Fermentation Convergence Technology, Kookmin University, Seoul 02707, Republic of Korea.
authors.forename: Hee-Eun
authors.initials: HE
authors.lastname: Jin
authors.affiliation: Department of Bio and Fermentation Convergence Technology, Kookmin University, Seoul 02707, Republic of Korea.|BioLeaders Corporation, Daejeon 34028, Republic of Korea.
authors.forename: Jae-Chul
authors.initials: JC
authors.lastname: Choi
authors.affiliation: SKKU Advanced Institute of Nanotechnology, School of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea.
authors.forename: Yong Taik
authors.initials: YT
authors.lastname: Lim
authors.affiliation: Department of Bio and Fermentation Convergence Technology, Kookmin University, Seoul 02707, Republic of Korea.|BioLeaders Corporation, Daejeon 34028, Republic of Korea.
authors.forename: Moon-Hee
authors.initials: MH
authors.lastname: Sung
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001419:Bacteria / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D058491:Bacterial Load; D000068016:Eubacteriales / Q000254:growth & development / Q000302:isolation & purification; D003106:Colon / Q000737:chemistry / Q000382:microbiology; D005243:Feces / Q000382:microbiology; D000069196:Gastrointestinal Microbiome; D041981:Gastrointestinal Tract / Q000737:chemistry / Q000382:microbiology; D059014:High-Throughput Nucleotide Sequencing; D056546:Lactobacillales / Q000235:genetics / Q000302:isolation & purification; D051379:Mice; D011099:Polyglutamic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D056692:Prebiotics / Q000032:analysis; D012336:RNA, Ribosomal, 16S; D014018:Tissue Distribution
chemical_list: D056692:Prebiotics; D012336:RNA, Ribosomal, 16S; C511775:poly(gamma-glutamic acid); D011099:Polyglutamic Acid
keywords: Poly-γ-glutamate; gut microbiota; organ distributions; prebiotics