title: The synthesis of [1-14C]2-(1H-tetrazol-5-yl)acetic acid.
abstract: Tetrazoles are a common heterocyclic functionality in many biologically active molecules. [1-14C]2-(1H-Tetrazol-5-yl)acetic acid was required as an intermediate in the synthesis of a development candidate as part of a discovery phase program to complete metabolic profiling studies. [1-14C]2-(1H-Tetrazol-5-yl)acetic acid was prepared in 4 steps overall and in 3 radiochemical steps from K14CN in an overall 32% radiochemical yield.
authors.affiliation: Research and Development, Discovery Chemistry Platforms-Radiochemistry, Bristol-Myers Squibb, Princeton, NJ, USA.
authors.forename: Brad D
authors.initials: BD
authors.lastname: Maxwell
authors.affiliation: Research and Development, Discovery Chemistry Platforms-Radiochemistry, Bristol-Myers Squibb, Princeton, NJ, USA.
authors.forename: Scott B
authors.initials: SB
authors.lastname: Tran
mesh_terms: D000085:Acetates / Q000138:chemical synthesis* / Q000737:chemistry; D002250:Carbon Radioisotopes / Q000737:chemistry; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000737:chemistry; D013777:Tetrazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: C000625386:2-(1H-tetrazol-5-yl)acetic acid; D000085:Acetates; D002250:Carbon Radioisotopes; D019275:Radiopharmaceuticals; D013777:Tetrazoles
keywords: [1-14C]2-(1H-tetrazol-5-yl)acetic acid; carbon-14; radiolabeled; tetrazoles