title: Juvenile Particulate Osteochondral Allograft for Treatment of Osteochondral Lesions of the Talus: Detection of Altered Repair Tissue Biochemical Composition Using 7 Tesla MRI and T2 Mapping.
abstract: During the previous 2 decades, numerous surgical procedures have become available to treat osteochondral lesions of the talus. The objective of the present study was to use 7 Tesla (7T) magnetic resonance imaging (MRI) to quantify and compare T2 values (a marker of collagen architecture) of native tibiotalar cartilage and cartilage repair tissue in patients treated with a juvenile particulate allograft for osteochondral lesions of the talus. The institutional review board approved the present study, and all subjects provided written informed consent. We scanned the ankles of 7 cartilage repair patients using a 7T MRI scanner with a multi-echo spin-echo sequence to measure the cartilage T2 values. We assessed the cartilage T2 values in the talar repair tissue, adjacent native talar cartilage, and overlying tibial cartilage. We compared the differences between groups using the paired t test. The talar cartilage repair tissue demonstrated greater mean T2 relaxation times compared with the native adjacent talar cartilage (64.88 ± 12.23 ms versus 49.56 ± 7.82 ms; p = .043). The tibial cartilage regions overlying these talar cartilage regions demonstrated a trend toward greater T2 relaxation times (77.00 ± 31.29 ms versus 59.52 ± 7.89 ms; p = .067). 7T MRI can detect differences in T2 values in cartilage repair tissue compared with native cartilage and could be useful for monitoring the status of cartilage health after surgical intervention.
authors.affiliation: Resident Physician, Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, New York, NY.
authors.forename: Shaleen
authors.initials: S
authors.lastname: Vira
authors.affiliation: Resident Physician, Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, New York, NY.
authors.forename: Austin J
authors.initials: AJ
authors.lastname: Ramme
authors.affiliation: Assistant Professor, Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, New York, NY.
authors.forename: Cary
authors.initials: C
authors.lastname: Chapman
authors.affiliation: Research Scientist, Center for Biomedical Imaging, Department of Radiology, NYU Langone Medical Center, New York, NY.
authors.forename: Ding
authors.initials: D
authors.lastname: Xia
authors.affiliation: Professor, Center for Biomedical Imaging, Department of Radiology, NYU Langone Medical Center, New York, NY.
authors.forename: Ravinder R
authors.initials: RR
authors.lastname: Regatte
authors.affiliation: Associate Professor, Center for Biomedical Imaging, Department of Radiology, NYU Langone Medical Center, New York, NY. Electronic address: gregory.chang@nyumc.org.
authors.forename: Gregory
authors.initials: G
authors.lastname: Chang
mesh_terms: D000328:Adult; D000843:Ankle Joint / Q000000981:diagnostic imaging / Q000601:surgery; D002358:Cartilage, Articular / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery*; D017352:Echo-Planar Imaging / Q000379:methods*; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D010007:Osteochondritis / Q000000981:diagnostic imaging / Q000601:surgery; D012189:Retrospective Studies; D012307:Risk Factors; D012494:Sampling Studies; D013628:Talus / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D016378:Tissue Transplantation / Q000379:methods*; D014184:Transplantation, Homologous / Q000379:methods; D016896:Treatment Outcome
keywords: cartilage; collagen; magnetic resonance; talus; tibia