title: Prognostic Factors of Patients With Transmural Advanced Gastric Carcinoma.
abstract: BACKGROUND
  The purpose of this study is to evaluate perioperative morbidity, mortality and the prognostic factors that influence survival of the patients with transmural advanced gastric carcinoma after curative surgical therapy.
  
  
  METHODS
  Fifty patients with transmural advanced gastric adenocarcinoma underwent curative resection in our clinic. The records of the patients were reviewed and the prognostic factors such as age, gender, location and size of the tumor, type of surgery, blood transfusion, depth of tumor invasion, lymph node metastases, stage of the disease, grading, vascular invasion, lymph vessel invasion, characteristics of the tumor according to Lauren's classification, and lymph node ratio were evaluated by using statistical methods.
  
  
  RESULTS
  In a total of 12 patients (24%) major morbidities developed, and five patients (10%) died. The overall survival rate was 48% at 1 year, 31% at 3 years, and 19% at 5 years. Lymph node metastases (P = 0.03), lymph vessel invasion (P = 0.001), blood transfusion (P = 0.021), and lymph node ratio (P = 0.006) were the prognostic features identified by univariate analysis. Among the multiple significant prognostic factors in the univariate analysis only one factor, lymph node ratio, proved to be independently significant in the multivariate analysis (RR: 4.47).
  
  
  CONCLUSIONS
  Our data showed that we can expect a good survival for patients with a lymph node ratio less than 0.2.
authors.affiliation: Third Surgical Clinic of Atatürk Training and Research Hospital, Izmir, Turkey.
authors.forename: Hayrullah
authors.initials: H
authors.lastname: Derici
authors.affiliation: Third Surgical Clinic of Atatürk Training and Research Hospital, Izmir, Turkey.
authors.forename: Ismail
authors.initials: I
authors.lastname: Yaman
authors.affiliation: Third Surgical Clinic of Atatürk Training and Research Hospital, Izmir, Turkey.
authors.forename: Tugrul
authors.initials: T
authors.lastname: Tansug
authors.affiliation: Third Surgical Clinic of Atatürk Training and Research Hospital, Izmir, Turkey.
authors.forename: Okay
authors.initials: O
authors.lastname: Nazli
authors.affiliation: Third Surgical Clinic of Atatürk Training and Research Hospital, Izmir, Turkey.
authors.forename: Ali Dogan
authors.initials: AD
authors.lastname: Bozdag
authors.affiliation: Third Surgical Clinic of Atatürk Training and Research Hospital, Izmir, Turkey.
authors.forename: Ali Serdar
authors.initials: AS
authors.lastname: Isguder
keywords: Advanced; Gastric Cancer; Morbidity; Mortality; Survival; Transmural