title: Metabolic and carbohydrate characteristics of different phenotypes of polycystic ovary syndrome.
abstract: OBJECTIVE
  To compare the prevalence of various metabolic and cardiovascular risk factors and insulin resistance between polycystic ovary syndrome (PCOS) patients with or without hyperandrogenism.
  
  
  METHODS
  This is a retrospective cross-sectional study involving women with PCOS as diagnosed according to the Androgen Excess (AE) Society definition (n=504) and women with normoandrogenemic PCOS (n=183). Anthropometrics, lipid profile, glucose, insulin, oral glucose tolerance test (OGTT), and reproductive hormone levels were evaluated.
  
  
  RESULTS
  Women with PCOS diagnosed according to the AE Society had a significantly higher prevalence of metabolic syndrome compared with the normoandrogenemic PCOS phenotype: odds ratio (OR) 2.95 [95% confidence interval (CI) 1.21-7.21]. There was no significant difference in the prevalence glucose intolerance test between the groups [OR: 2.15, 95% CI 0.71-6.56]. The prevalence of low high density lipoprotein (HDL)-cholesterol in the group under the AE-PCOS Society criteria was higher than that of the normoandrogenemic PCOS group [OR: 2.82, 95%CI 1.29-3.36].
  
  
  CONCLUSIONS
  The risks of metabolic syndrome and cardiovascular disease may vary among the phenotypes of PCOS based on the Rotterdam criteria. This new data may be of reference in informing women with PCOS, although further prospective studies are needed to validate this proposition.
authors.affiliation: Department of Obstetrics and Gynecology, İnönü University School of Medicine, Malatya, Turkey.
authors.forename: Ebru
authors.initials: E
authors.lastname: Çelik
authors.affiliation: Department of Obstetrics and Gynecology, İnönü University School of Medicine, Malatya, Turkey.
authors.forename: Ilgın
authors.initials: I
authors.lastname: Türkçüoğlu
authors.affiliation: Department of Obstetrics and Gynecology, Koç University School of Medicine, İstanbul, Turkey.
authors.forename: Barış
authors.initials: B
authors.lastname: Ata
authors.affiliation: Department of Obstetrics and Gynecology, İnönü University School of Medicine, Malatya, Turkey.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Karaer
authors.affiliation: Department of Obstetrics and Gynecology, İnönü University School of Medicine, Malatya, Turkey.
authors.forename: Pınar
authors.initials: P
authors.lastname: Kırıcı
authors.affiliation: Department of Obstetrics and Gynecology, İnönü University School of Medicine, Malatya, Turkey.
authors.forename: Sevil
authors.initials: S
authors.lastname: Eraslan
authors.affiliation: Department of Clinical Biochemistry, İnönü University School of Medicine, Malatya, Turkey.
authors.forename: Çağatay
authors.initials: Ç
authors.lastname: Taşkapan
authors.affiliation: Department of Obstetrics and Gynecology, Ankara University School of Medicine, Ankara, Turkey.
authors.forename: Bülent
authors.initials: B
authors.lastname: Berker
keywords: Polycystic ovary syndrome; diagnostic categories; hyperanderogenism; insulin resistance; metabolic syndrome