title: Association of polymorphisms in the telomere-related gene ACYP2 with lung cancer risk in the Chinese Han population.
abstract: Single nucleotide polymorphisms (SNPs) in the telomere-associated gene ACYP2 are associated with increased lung cancer risk. We explored the correlation between ACYP2 SNPs and lung cancer susceptibility in the Chinese Han population. A total of 554 lung cancer patients and 603 healthy controls were included in this study. Thirteen SNPs in ACYP2 were selected. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated using unconditional logistic regression analysis. Multivariate logistic regression analysis was used assess the correlation between SNPs and lung cancer. We found that rs1682111 was associated with increased lung cancer risk in the recessive model (crude, OR=1.50, 95%CI: 1.04-2.16, p=0.029; adjusted for age, OR=1.55, 95%CI: 1.04-2.30, p=0.029), as was rs11896604 in the codominant model (crude, OR=0.65, 95%CI: 0.33-1.28, p=0.045; adjusted for age, OR=0.74, 95%CI: 0.36-1.53, p=0.049) and over-dominant model (crude, OR=1.30, 95%CI: 1.02-1.66, p=0.032; adjusted for age, OR=1.37, 95%CI: 1.05-1.78, p=0.020). Finally, rs843720 was associated with increased lung cancer risk in the recessive model (crude, OR=1.43, 95%CI: 1.02-2.02, p=0.040; adjusted for age, OR=1.48, 95%CI: 1.02-2.15, p=0.040). Thus three SNPs in ACYP2 (rs1682111, rs11896604 and rs843720) associate with lung cancer in the Chinese Han population.
authors.affiliation: Department of Thoracic Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China.
authors.forename: Nanzheng
authors.initials: N
authors.lastname: Chen
authors.affiliation: Hospital 521 of China's Ordnance Industry Group, Xi'an 710065, Shaanxi, China.
authors.forename: Xiaomei
authors.initials: X
authors.lastname: Yang
authors.affiliation: Inner Mongolia Medical University, Hohhot 010050, Inner Mongolia, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Guo
authors.affiliation: Department of Thoracic Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China.
authors.forename: Jiangtao
authors.initials: J
authors.lastname: You
authors.affiliation: Department of Thoracic Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China.
authors.forename: Qifei
authors.initials: Q
authors.lastname: Wu
authors.affiliation: Department of Thoracic Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China.
authors.forename: Guangjian
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Department of Thoracic Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China.
authors.forename: Haijun
authors.initials: H
authors.lastname: Li
authors.affiliation: School of Continuing Education of Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China.
authors.forename: Donghong
authors.initials: D
authors.lastname: Geng
authors.affiliation: School of Life Sciences, Northwest University, Xi'an 710069, Shaanxi, China.
authors.forename: Tianbo
authors.initials: T
authors.lastname: Jin
authors.affiliation: Department of Thoracic Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China.
authors.forename: Junke
authors.initials: J
authors.lastname: Fu
authors.affiliation: Department of Thoracic Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D017766:Acid Anhydride Hydrolases / Q000235:genetics*; D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D016015:Logistic Models; D008175:Lung Neoplasms / Q000209:etiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D000097024:Acylphosphatase
chemical_list: D017766:Acid Anhydride Hydrolases; C000612927:ACYP2 protein, human; D000097024:Acylphosphatase
keywords: association study; lung cancer; single nucleotide polymorphisms (SNPs); telomere-related gene