title: Exercise and Beta-Glucan Consumption (Saccharomyces cerevisiae) Improve the Metabolic Profile and Reduce the Atherogenic Index in Type 2 Diabetic Rats (HFD/STZ).
abstract: Physical activity and the ingestion of dietary fiber are non-drug alternatives commonly used as adjuvants to glycemic control in diabetic individuals. Among these fibers, we can highlight beta-glucans. However, few studies have compared isolated and synergic effects of physical exercise and beta-glucan ingestion, especially in type 2 diabetic rats. Therefore, we evaluated the effects beta-glucan (Saccharomyces cerevisiae) consumption, associated or not to exercise, on metabolic parameters of diabetic Wistar rats. The diabetesmellitus(DM) was induced by high-fat diet (HFD) associated with a low dose of streptozotocin (STZ-35 mg/kg). Trained groups were submitted to eight weeks of exercise in aquatic environment. In the last 28 days of experiment, animals received 30 mg/kg/day of beta-glucan by gavage. Isolated use of beta-glucan decreased glucose levels in fasting, Glycated hemoglobin (HbA1c), triglycerides (TAG), total cholesterol (TC), low-density lipoprotein (LDL-C), the atherogenic index of plasma. Exercise alone also decreased blood glucose levels, HbA1c, and renal lesions. An additive effect for reducing the atherogenic index of plasma and renal lesions was observed when both treatments were combined. It was concluded that both beta-glucan and exercise improved metabolic parameters in type 2 (HFD/STZ) diabetic rats.
authors.affiliation: Department of Veterinary Medicine, Federal University of Lavras, Mail Box 3037, Lavras 37200-000, Brazil. ericfrancelinoandrade@gmail.com.
authors.forename: Eric Francelino
authors.initials: EF
authors.lastname: Andrade
authors.affiliation: Department of Health Sciences, Federal University of Lavras, Mail Box 3037, Lavras 37200-000, Brazil. andressaveigalima@outlook.com.
authors.forename: Andressa Ribeiro Veiga
authors.initials: AR
authors.lastname: Lima
authors.affiliation: Department of Animal Sciences, Federal University of Lavras, Mail Box 3037, Lavras 37200-000, Brazil. inunes2611@gmail.com.
authors.forename: Ingrid Edwiges
authors.initials: IE
authors.lastname: Nunes
authors.affiliation: Department of Agricultural Sciences, Federal University of Jequitinhonha and Mucuri Valleys, Rua Vereador João Narciso, 1380-Bairro Cachoeira, Unaí 3861-000, Brazil. debora.ribeiro@ufvjm.edu.br.
authors.forename: Débora Ribeiro
authors.initials: DR
authors.lastname: Orlando
authors.affiliation: Department of Veterinary Medicine, Federal University of Lavras, Mail Box 3037, Lavras 37200-000, Brazil. pngondim@hotmail.com.
authors.forename: Paula Novato
authors.initials: PN
authors.lastname: Gondim
authors.affiliation: Department of Veterinary Medicine, Federal University of Lavras, Mail Box 3037, Lavras 37200-000, Brazil. zangeronimo@prpg.ufla.br.
authors.forename: Márcio Gilberto
authors.initials: MG
authors.lastname: Zangeronimo
authors.affiliation: Department of Health Sciences, Federal University of Lavras, Mail Box 3037, Lavras 37200-000, Brazil. fernando.ferrari@dsa.ufla.br.
authors.forename: Fernando Henrique Ferrari
authors.initials: FH
authors.lastname: Alves
authors.affiliation: Department of Health Sciences, Federal University of Lavras, Mail Box 3037, Lavras 37200-000, Brazil. lucianojosepereira@dsa.ufla.br.
authors.forename: Luciano José
authors.initials: LJ
authors.lastname: Pereira
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000097:blood / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control*; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D003131:Combined Modality Therapy; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000139:chemically induced / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000139:chemically induced / Q000175:diagnosis / Q000628:therapy*; D003925:Diabetic Angiopathies / Q000097:blood / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control*; D003928:Diabetic Nephropathies / Q000209:etiology / Q000517:prevention & control; D059305:Diet, High-Fat; D004043:Dietary Fiber / Q000008:administration & dosage*; D019587:Dietary Supplements; D005081:Exercise Therapy; D006442:Glycated Hemoglobin / Q000378:metabolism; D008055:Lipids / Q000097:blood; D008297:Male; D017208:Rats, Wistar; D012441:Saccharomyces cerevisiae / Q000378:metabolism*; D013311:Streptozocin; D047071:beta-Glucans / Q000008:administration & dosage* / Q000302:isolation & purification
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D004043:Dietary Fiber; D006442:Glycated Hemoglobin; D008055:Lipids; D013311:Streptozocin; D047071:beta-Glucans
keywords: dietary fibers; glycemic control; metabolic profile