title: Clinical correlates of leukoaraiosis: A study of 175 patients.
abstract: BACKGROUND
  In India, the correlates of leukoaraiosis (LA) have not been widely reported. This study was designed to investigate the factors which correlate with LA.
  
  
  METHODS
  We included patients with LA who consented for the study and graded their severity on the basis of Fazekas scale. We excluded patients with LA who did not consent/cooperate for the study as also patients with other white matter changes which mimic LA.
  
  
  RESULTS
  LA is a common and under-rated cause of disability. Presentations include cognitive decline, gait disturbance, dysarthria, bladder/bowel sphincter disturbances, and increased risk of stroke. The comorbidities include hyperhomocysteinemia, hypertension, dyslipidemia, tobacco use, ischemic heart disease, previous stroke, atrial fibrillation, chronic renal failure, and bariatric surgery.
authors.affiliation: Consultant Neurologist, Pune, Maharashtra, India.
authors.forename: Rustom S
authors.initials: RS
authors.lastname: Wadia
authors.affiliation: Consultant Radiologist, Pune, Maharashtra, India.
authors.forename: Sandesh K
authors.initials: SK
authors.lastname: Ghiya
authors.affiliation: Resident at Ruby Hall Clinic, Pune, Maharashtra, India.
authors.forename: Joshita
authors.initials: J
authors.lastname: Singh
authors.affiliation: Consultant Neurologist, Pune, Maharashtra, India.
authors.forename: Santosh M
authors.initials: SM
authors.lastname: Sontakke
authors.affiliation: Assistant Professor, Bharati Medical College, Pune, Maharashtra, India.
authors.forename: Vishwas
authors.initials: V
authors.lastname: Bharadwaj
authors.affiliation: Assistant Professor, Bharati Medical College, Pune, Maharashtra, India.
authors.forename: Rahul V
authors.initials: RV
authors.lastname: Sonawane
authors.affiliation: Assistant Professor, Bharati Medical College, Pune, Maharashtra, India.
authors.forename: Yogesh P
authors.initials: YP
authors.lastname: Bade
authors.affiliation: Assistant Professor, Bharati Medical College, Pune, Maharashtra, India.
authors.forename: K
authors.initials: K
authors.lastname: Shrikanth
authors.affiliation: Assistant Professor, Bharati Medical College, Pune, Maharashtra, India.
authors.forename: Nikhil
authors.initials: N
authors.lastname: Goli
authors.affiliation: Assistant Professor, Bharati Medical College, Pune, Maharashtra, India.
authors.forename: Rohit Singh
authors.initials: RS
authors.lastname: Chauhan
authors.affiliation: Consultant Neurologist, Columbia Asia Hospital, Pune, Maharashtra, India.
authors.forename: Nilesh A
authors.initials: NA
authors.lastname: Nadkarni
keywords: Cognitive decline; gait and sphincter disturbances; leukoaraiosis