title: Aptamer-Binding Directed DNA Origami Pattern for Logic Gates.
abstract: In this study, an aptamer-substrate strategy is introduced to control programmable DNA origami pattern. Combined with DNA aptamer-substrate binding and DNAzyme-cutting, small DNA tiles were specifically controlled to fill into the predesigned DNA origami frame. Here, a set of DNA logic gates (OR, YES, and AND) are performed in response to the stimuli of adenosine triphosphate (ATP) and cocaine. The experimental results are confirmed by AFM imaging and time-dependent fluorescence changes, demonstrating that the geometric patterns are regulated in a controllable and programmable manner. Our approach provides a new platform for engineering programmable origami nanopatterns and constructing complex DNA nanodevices.
authors.affiliation: School of Control and Computer Engineering, North China Electric Power University , Beijing 102206, China.|Department of Chemistry and Biochemistry Center for Molecule Design and Biominetics at the Biodesign Institute, Arizona State University , Tempe, Arizona 85287, United States.
authors.forename: Jing
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Chemistry and Biochemistry Center for Molecule Design and Biominetics at the Biodesign Institute, Arizona State University , Tempe, Arizona 85287, United States.
authors.forename: Shuoxing
authors.initials: S
authors.lastname: Jiang
authors.affiliation: Department of Computer Science, Xiamen University , Xiamen 361005, China.
authors.forename: Xiangrong
authors.initials: X
authors.lastname: Liu
authors.affiliation: Key Laboratory of Image Information Processing and Intelligent Control, School of Automation, Huazhong University of Science and Technology , Wuhan 430074, China.
authors.forename: Linqiang
authors.initials: L
authors.lastname: Pan
authors.affiliation: Department of Chemistry and Biochemistry Center for Molecule Design and Biominetics at the Biodesign Institute, Arizona State University , Tempe, Arizona 85287, United States.|Institute of Software, School of Electronics Engineering and Computer Science, Peking University , Beijing 100871, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Zhang
mesh_terms: D004247:DNA; D008128:Logic; D009841:Oligonucleotides / Q000737:chemistry*
chemical_list: D009841:Oligonucleotides; D004247:DNA
keywords: DNA origami; DNAzyme; aptamer; logic gate; tile filling