title: Surgical treatment of pulmonary metastases in pediatric solid tumors.
abstract: Most children who succumb to solid malignancies do so because of the burden of metastatic disease or due to complications associated with the therapy administered to treat metastatic disease. Approximately one-quarter of children with solid tumors will present with metastatic disease, and an additional 20% ultimately develop metastatic disease, most commonly in the lung. The role of surgery in the treatment of metastatic solid tumors, given its disseminated nature, is not intuitive, yet there are circumstances in which surgical resection of metastatic disease can potentially be curative. However, the utility of surgery is very much dependent on histology, and generally is most appropriate for those malignancies with histologies that are refractory to other adjuvant therapies.
authors.affiliation: Pediatric Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY. Electronic address: heatont@mskcc.org.
authors.forename: Todd E
authors.initials: TE
authors.lastname: Heaton
authors.affiliation: Department of Surgery, St. Jude Children's Research Hospital, Memphis, TN.
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Davidoff
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000473:pathology; D018268:Adrenocortical Carcinoma / Q000000981:diagnostic imaging / Q000556:secondary / Q000601:surgery; D002648:Child; D018197:Hepatoblastoma / Q000000981:diagnostic imaging / Q000556:secondary / Q000601:surgery; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary* / Q000601:surgery*; D009447:Neuroblastoma / Q000000981:diagnostic imaging / Q000556:secondary / Q000601:surgery; D010372:Pediatrics; D011013:Pneumonectomy; D012509:Sarcoma / Q000000981:diagnostic imaging / Q000556:secondary / Q000601:surgery; D014057:Tomography, X-Ray Computed; D009396:Wilms Tumor / Q000000981:diagnostic imaging / Q000556:secondary / Q000601:surgery
keywords: Management of metastatic pediatric embryonal tumors; Management of metastatic sarcoma; Pediatric lung metastases; Pediatric solid tumor; Surgical resection of metastatic disease