title: The association of vaspin rs2236242 and leptin rs7799039 polymorphism with metabolic syndrome in Egyptian women.
abstract: OBJECTIVE
  Genetic predisposition is implicated in the etiology of metabolic syndrome. This study aimed to investigate the1397645907association of vaspin rs2236242 and leptin rs7799039 polymorphisms with their serum levels and with the risk of developing metabolic syndrome in Egyptian women.
  
  
  METHODS
  This case control study included 100 Egyptian women with metabolic syndrome and 100 without metabolic syndrome. The genotypes of vaspin rs2236242 and leptin rs7799039 were detected by a methodology based on PCR-RFLP. Serum vaspin and leptin levels were determined by ELISA.
  
  
  RESULTS
  The metabolic syndrome group was associated with higher serum vaspin and leptin levels when compared to the nonmetabolic syndrome group. The AA genotype of leptin rs7799039 was associated with metabolic syndrome and with higher serum leptin levels, while the different genotypes of vaspin rs2236242 were not associated with metabolic syndrome or different serum vaspin levels.
  
  
  CONCLUSIONS
  The AA genotype of leptin rs7799039 was associated with metabolic syndrome and higher serum leptin levels﻿. Serum leptin and vaspin can be used as diagnostic markers of metabolic syndrome.
authors.affiliation: Department of Clinical Biochemistry, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.|Department of Medical Biochemistry, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
authors.forename: Amina
authors.initials: A
authors.lastname: Alnory
authors.affiliation: Department of Clinical Biochemistry, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.|Department of Medical Biochemistry, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
authors.forename: Hoda
authors.initials: H
authors.lastname: Gad
authors.affiliation: Department of Clinical Biochemistry, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.|Department of Medical Biochemistry, National Research Center, Cairo, Egypt.
authors.forename: Gehan
authors.initials: G
authors.lastname: Hegazy
authors.affiliation: Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Cairo, Egypt.
authors.forename: Olfat
authors.initials: O
authors.lastname: Shaker
mesh_terms: D016022:Case-Control Studies; D004534:Egypt; D005260:Female; D005838:Genotype; D006801:Humans; D020738:Leptin / Q000235:genetics*; D024821:Metabolic Syndrome; D011110:Polymorphism, Genetic; D015843:Serpins / Q000235:genetics*
chemical_list: D020738:Leptin; C507339:SERPINA12 protein, human; D015843:Serpins
keywords: Gene polymorphism; leptin rs7799039; metabolic syndrome; vaspin rs2236242