title: Three new benzolactones from Lavandula angustifolia and their bioactivities.
abstract: Three new benzolactones (1-3), together with four known ones (4-7), were isolated from the whole herb of Lavandula angustifolia. Their structures were established on the basis of detailed spectroscopic analysis (1D- and 2D-NMR, HRESIMS, UV, and IR) and comparison with data reported in the literature. New compounds were evaluated for their anti-tobacco mosaic virus (TMV) activities and cytotoxic activities. The results revealed that compounds 1-3 showed obvious anti-TMV activities with inhibition rates of 26.9, 30.2, and 28.4%, which were at the same grade as positive control. Compounds 1-3 also showed weak inhibitory activities against some tested human tumor cell lines with IC50values in the range of 32.1-7.6 μM.
authors.affiliation: a Key Laboratory of Tobacco Chemistry of Yunnan Province , China Tobacco Yunnan Industrial Co., Ltd , Kunming 650231 , China.|b School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Nature Products , Kunming Medical University , Kunming 650500 , China.
authors.forename: Jian-Lian
authors.initials: JL
authors.lastname: Shi
authors.affiliation: a Key Laboratory of Tobacco Chemistry of Yunnan Province , China Tobacco Yunnan Industrial Co., Ltd , Kunming 650231 , China.
authors.forename: Shi-Yun
authors.initials: SY
authors.lastname: Tang
authors.affiliation: a Key Laboratory of Tobacco Chemistry of Yunnan Province , China Tobacco Yunnan Industrial Co., Ltd , Kunming 650231 , China.
authors.forename: Chun-Bo
authors.initials: CB
authors.lastname: Liu
authors.affiliation: a Key Laboratory of Tobacco Chemistry of Yunnan Province , China Tobacco Yunnan Industrial Co., Ltd , Kunming 650231 , China.
authors.forename: Ling
authors.initials: L
authors.lastname: Ye
authors.affiliation: c School of Chemical Science and Technology , Yunnan University , Kunming 650091 , China.
authors.forename: Pei-Song
authors.initials: PS
authors.lastname: Yang
authors.affiliation: a Key Laboratory of Tobacco Chemistry of Yunnan Province , China Tobacco Yunnan Industrial Co., Ltd , Kunming 650231 , China.
authors.forename: Feng-Mei
authors.initials: FM
authors.lastname: Zhang
authors.affiliation: a Key Laboratory of Tobacco Chemistry of Yunnan Province , China Tobacco Yunnan Industrial Co., Ltd , Kunming 650231 , China.
authors.forename: Pei
authors.initials: P
authors.lastname: He
authors.affiliation: a Key Laboratory of Tobacco Chemistry of Yunnan Province , China Tobacco Yunnan Industrial Co., Ltd , Kunming 650231 , China.
authors.forename: Zhi-Hua
authors.initials: ZH
authors.lastname: Liu
authors.affiliation: a Key Laboratory of Tobacco Chemistry of Yunnan Province , China Tobacco Yunnan Industrial Co., Ltd , Kunming 650231 , China.
authors.forename: Ming-Ming
authors.initials: MM
authors.lastname: Miao
authors.affiliation: b School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Nature Products , Kunming Medical University , Kunming 650500 , China.
authors.forename: Ya-Dong
authors.initials: YD
authors.lastname: Guo
authors.affiliation: a Key Laboratory of Tobacco Chemistry of Yunnan Province , China Tobacco Yunnan Industrial Co., Ltd , Kunming 650231 , China.
authors.forename: Qin-Peng
authors.initials: QP
authors.lastname: Shen
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D011564:Furocoumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D027523:Lavandula / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D014027:Tobacco Mosaic Virus / Q000187:drug effects
chemical_list: C000622130:4-hydroxy-6-(2-oxopropyl)isobenzofuran-1(3H)-one; C000622131:4-hydroxymethyl-6-(2-oxopropyl)-isobenzofuran-1(3H)-one; C000622129:89-dihydro-77-dimethyl-1H-furo(34-f)chromen-3(7H)-one; D000998:Antiviral Agents; D001572:Benzofurans; D004365:Drugs, Chinese Herbal; D011564:Furocoumarins; D007783:Lactones
keywords: Lamiaceae; Lavandula angustifolia; anti-tobacco mosaic virus (TMV) activities; benzolactones; cytotoxic activities