title: A Case-control Study for the Assessment of Correlation of Denture-related Sores and Oral Cancer Risk.
abstract: BACKGROUND
  Oral cancer is one of the most common cancers in the world. Although multifactorial, the exact pathogenesis of oral cancer is still unclear. Apart from tobacco chewing and smoking, chronic long-term irritation by ill-fitting denture is also said to be an important risk factor for the development of oral cancer. Literature quotes some amount of evidence that correlates long-term denture irritation as a risk factor for the development of oral cancer. Hence, we analyzed the correlation of denture-related sores as a risk factor for the development of oral cancer.
  
  
  METHODS
  The present case-control study included 140 newly diagnosed oral cancer cases and 140 patients as the control healthy group. One-hour questionnaire was framed and was conducted to the control group and the study group by 10 experienced interviewers who were trained for such type of analysis. Assessment of the patients' socioeconomic status, cigarette smoking habit, alcohol drinking habit, and oral health status was done and compared on the two study groups. Logistic regression models along with multivariate models were used for the assessment of the results.
  
  
  RESULTS
  In the control group and the cancer patient group, total of 140 new cancer cases and 140 subjects were included. Out of 140 patients in the cancer group, 16 were nonsmokers, while 110 smoked cigarette in the cancer patient group. As far as alcohol consumption is concerned, 42 patients in the control group and 102 patients in the oral cancer group were chronic heavy drinkers. Fried food intake was high in both the groups. Significant correlation was obtained while comparing the heavy smokers, heavy alcohol consumers, and oral health status in both the study groups.
  
  
  CONCLUSIONS
  Our results favor the hypothesis that positive correlation exists between oral cancer risk and recurrent denture sores.
  
  
  CONCLUSIONS
  People wearing denture prosthesis should be periodically visualized for identification of any mucosal alteration or changes at the earliest.
authors.affiliation: Department of Prosthodontics, Buraydah Colleges, Burhaydah Al Qassim, Kingdom of Saudi Arabia, Phone: +966576578455, e-mail: drpreetjain@gmail.com.
authors.forename: Preet
authors.initials: P
authors.lastname: Jain
authors.affiliation: Department of Periodontics, Buraydah Colleges, Burhaydah Al Qassim, Kingdom of Saudi Arabia.
authors.forename: Meetu
authors.initials: M
authors.lastname: Jain
authors.affiliation: Department of Oral and Maxillofacial Pathology and Microbiology, Geetanjali Dental and Research Institute, Udaipur Rajasthan, India.
authors.forename: B Vikas
authors.initials: BV
authors.lastname: Prasad
authors.affiliation: Department of Public Health Dentistry, Geetanjali Dental and Research Institute, Udaipur, Rajasthan, India.
authors.forename: Gauri S
authors.initials: GS
authors.lastname: Kakatkar
authors.affiliation: Pacific Dental College and Hospital, Udaipur, Rajasthan, India.
authors.forename: Maulik
authors.initials: M
authors.lastname: Patel
authors.affiliation: Pacific Dental College and Hospital, Udaipur, Rajasthan, India.
authors.forename: Javed
authors.initials: J
authors.lastname: Khan
mesh_terms: D000428:Alcohol Drinking / Q000009:adverse effects; D016022:Case-Control Studies; D003778:Dentures / Q000009:adverse effects*; D005247:Feeding Behavior; D006801:Humans; D016015:Logistic Models; D009062:Mouth Neoplasms / Q000453:epidemiology* / Q000209:etiology*; D009909:Oral Health; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D012923:Social Class; D011795:Surveys and Questionnaires
keywords: Denture; Oral cancer Risk.