title: Review on the role of AMPA receptor nano-organization and dynamic in the properties of synaptic transmission.
abstract: Receptor trafficking and its regulation have appeared in the last two decades to be a major controller of basal synaptic transmission and its activity-dependent plasticity. More recently, considerable advances in super-resolution microscopy have begun deciphering the subdiffraction organization of synaptic elements and their functional roles. In particular, the dynamic nanoscale organization of neurotransmitter receptors in the postsynaptic membrane has recently been suggested to play a major role in various aspects of synapstic function. We here review the recent advances in our understanding of alpha-amino-3-hydroxy-5-méthyl-4-isoxazolepropionic acid subtype glutamate receptors subsynaptic organization and their role in short- and long-term synaptic plasticity.
authors.affiliation: University of Bordeaux, Interdisciplinary Institute for Neuroscience, UMR 5297, Bordeaux F-33000, France; Interdisciplinary Institute for Neuroscience, CNRS, UMR 5297, Bordeaux F-33000, France.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Compans
authors.affiliation: University of Bordeaux, Interdisciplinary Institute for Neuroscience, UMR 5297, Bordeaux F-33000, France; Interdisciplinary Institute for Neuroscience, CNRS, UMR 5297, Bordeaux F-33000, France; University of Bordeaux, Bordeaux Imaging Center, UMS 3420 CNRS, US4 INSERM, France.
authors.forename: Daniel
authors.initials: D
authors.lastname: Choquet
authors.affiliation: University of Bordeaux, Interdisciplinary Institute for Neuroscience, UMR 5297, Bordeaux F-33000, France; Interdisciplinary Institute for Neuroscience, CNRS, UMR 5297, Bordeaux F-33000, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Hosy
keywords: receptor trafficking; super-resolution microscopy; synaptic plasticity