title: 5-Hydroxyvitamin D concentration in paediatric cancer patients from Scotland: a prospective cohort study.
abstract: Children with cancer are potentially at a high risk of plasma 25-hydroxyvitamin D (25(OH)D) inadequacy, and despite UK vitamin D supplementation guidelines their implementation remains inconsistent. Thus, we aimed to investigate 25(OH)D concentration and factors contributing to 25(OH)D inadequacy in paediatric cancer patients. A prospective cohort study of Scottish children aged 75 nmol/l). In all, eighty-two patients (median age 3·9, interquartile ranges (IQR) 1·9-8·8; 56 % males) and thirty-five controls (median age 6·2, IQR 4·8-9·1; 49 % males) were recruited. 25(OH)D inadequacy was highly prevalent in the controls (63 %; 22/35) and in the patients (64 %; 42/65) at both baseline and during treatment (33-50 %). Non-supplemented children had the highest prevalence of 25(OH)D inadequacy at every stage with 25(OH)D median ranging from 32·0 (IQR 21·0-46·5) to 45·0 (28·0-64·5) nmol/l. Older age at baseline (R -0·46; P<0·001), overnutrition (BMI≥85th centile) at 3 months (P=0·005; relative risk=3·1) and not being supplemented at 6 months (P=0·04; relative risk=4·3) may have contributed to lower plasma 25(OH)D. Paediatric cancer patients are not at a higher risk of 25(OH)D inadequacy than healthy children at diagnosis; however, prevalence of 25(OH)D inadequacy is still high and non-supplemented children have a higher risk. Appropriate monitoring and therapeutic supplementation should be implemented.
authors.affiliation: 1Dietetics, Nutrition and Biological Health Sciences,Queen Margaret University,Edinburgh,EH21 6UU,UK.
authors.forename: Raquel Revuelta
authors.initials: RR
authors.lastname: Iniesta
authors.affiliation: 1Dietetics, Nutrition and Biological Health Sciences,Queen Margaret University,Edinburgh,EH21 6UU,UK.
authors.forename: Ilenia
authors.initials: I
authors.lastname: Paciarotti
authors.affiliation: 1Dietetics, Nutrition and Biological Health Sciences,Queen Margaret University,Edinburgh,EH21 6UU,UK.
authors.forename: Isobel
authors.initials: I
authors.lastname: Davidson
authors.affiliation: 1Dietetics, Nutrition and Biological Health Sciences,Queen Margaret University,Edinburgh,EH21 6UU,UK.
authors.forename: Jane M
authors.initials: JM
authors.lastname: McKenzie
authors.affiliation: 3Department of Paediatric Neuroscience,Royal Hospital for Sick Children,Edinburgh,EH9 1LF,UK.
authors.forename: Celia
authors.initials: C
authors.lastname: Brand
authors.affiliation: 2Child Life and Health,University of Edinburgh,Edinburgh,EH9 1UW,UK.
authors.forename: Richard F M
authors.initials: RF
authors.lastname: Chin
authors.affiliation: 5Department of Haematology and Oncology,Royal Hospital for Sick Children,Edinburgh,EH9 1LF,UK.
authors.forename: Mark F H
authors.initials: MF
authors.lastname: Brougham
authors.affiliation: 2Child Life and Health,University of Edinburgh,Edinburgh,EH9 1UW,UK.
authors.forename: David C
authors.initials: DC
authors.lastname: Wilson
mesh_terms: D015652:25-Hydroxyvitamin D 2 / Q000097:blood*; D000293:Adolescent; D000367:Age Factors; D015992:Body Mass Index; D002112:Calcifediol / Q000097:blood*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D009369:Neoplasms / Q000097:blood / Q000150:complications* / Q000473:pathology / Q000628:therapy; D044343:Overnutrition / Q000150:complications; D010865:Pilot Projects; D015995:Prevalence; D011446:Prospective Studies; D012306:Risk; D012606:Scotland / Q000453:epidemiology; D012720:Severity of Illness Index; D014808:Vitamin D Deficiency / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology
chemical_list: D015652:25-Hydroxyvitamin D 2; D002112:Calcifediol
keywords:  25(OH)D 25-hydroxyvitamin D;  IQR interquartile ranges;  PTH parathyroid hormone; 25-Hydroxyvitamin D; Cancer; Paediatrics; Scotland