title: DAPK1 Keeps the Peace in Antifungal Inflammation.
abstract: Unabated inflammation and impaired antifungal immunity underlie genetic defects in NOX-2-dependent activation of LC3-associated phagocytosis (LAP). In this issue of Cell Host & Microbe, Oikonomou et al. (2016) identify a molecular link between IFN-γ/DAPK1 signaling, the proteosomal degradation pathway, and LAP that is critical for dampening Aspergillus-triggered immunopathology.
authors.affiliation: Department of Clinical Microbiology and Microbial Pathogenesis, School of Medicine, University of Crete, 71300 Heraklion, Crete, Greece.
authors.forename: Tonia
authors.initials: T
authors.lastname: Akoumianaki
authors.affiliation: Department of Clinical Microbiology and Microbial Pathogenesis, School of Medicine, University of Crete, 71300 Heraklion, Crete, Greece; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology, 71300 Heraklion, Crete, Greece. Electronic address: hamilos@imbb.forth.gr.
authors.forename: Georgios
authors.initials: G
authors.lastname: Chamilos
mesh_terms: D000893:Anti-Inflammatory Agents; D000935:Antifungal Agents / Q000009:adverse effects / Q000276:immunology*; D001228:Aspergillosis / Q000188:drug therapy / Q000276:immunology*; D001230:Aspergillus / Q000187:drug effects / Q000472:pathogenicity; D001232:Aspergillus fumigatus / Q000187:drug effects / Q000472:pathogenicity; D000071193:Autophagy-Related Protein 7; D000071186:Beclin-1; D064550:Death-Associated Protein Kinases / Q000378:metabolism* / Q000494:pharmacology*; D007249:Inflammation / Q000276:immunology*; D007371:Interferon-gamma / Q000378:metabolism / Q000494:pharmacology; D008264:Macrophages / Q000382:microbiology; D010587:Phagocytosis / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology
chemical_list: D000893:Anti-Inflammatory Agents; D000935:Antifungal Agents; D000071186:Beclin-1; D007371:Interferon-gamma; C579096:DAPK1 protein, human; D064550:Death-Associated Protein Kinases; D000071193:Autophagy-Related Protein 7