abstract: The aim of this study was to evaluate the antiplaque effect of Ocimum gratissimum (Og) by in vivo investigation. Fifteen healthy volunteers participated in a crossover, double-blind clinical study, using a 3-day partial-mouth plaque accumulation model. The participants abolished any method of mechanical oral hygiene and they were randomly assigned to initially use just the following mouthrinses: distilled water (DW solution), 0.12% chlorhexidine digluconate (CLX solution) or 10% Og (Og solution). The plaque index (PLI) was recorded in all mandibular teeth at the end of the trial and the Kruskal-Wallis (α=0.05) and Mann-Whitney (α=0.05) tests were used to estimate the difference among groups. The clinical results showed statistically significant difference among the groups (p<0.05), favoring the CLX solution and Og solution, but the first was more effective (p<0.05). The mouthrinses containing 0.12% chlorhexidine digluconate and 10% Og were able to inhibit plaque re-growth, however Og showed more limited results in comparison to CLX.
authors.affiliation: Dental School, UNIFOR - University of Fortaleza, Fortaleza, CE, Brazil.
authors.forename: Manoela Siqueira
authors.initials: MS
authors.lastname: Pimenta
authors.affiliation: Dental School, UNIFOR - University of Fortaleza, Fortaleza, CE, Brazil.
authors.forename: Nayana Santiago Guedis
authors.initials: NS
authors.lastname: Lobo
authors.affiliation: Dental School, UNIFOR - University of Fortaleza, Fortaleza, CE, Brazil.
authors.forename: Virna Castelo
authors.initials: VC
authors.lastname: Vieira
authors.affiliation: School of Pharmacy, UNIFOR - University of Fortaleza, Fortaleza, CE, Brazil.
authors.forename: Ângela Maria Alves da
authors.initials: ÂM
authors.lastname: Costa
authors.affiliation: School of Pharmacy, UNIFOR - University of Fortaleza, Fortaleza, CE, Brazil.
authors.forename: Flávio Nogueira da
authors.initials: FN
authors.lastname: Costa
authors.affiliation: Dental School, UNIFOR - University of Fortaleza, Fortaleza, CE, Brazil.
authors.forename: Sérgio Luís da Silva
authors.initials: SL
authors.lastname: Pereira
mesh_terms: D000293:Adolescent; D000328:Adult; D002710:Chlorhexidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D018592:Cross-Over Studies; D003773:Dental Plaque / Q000517:prevention & control*; D003774:Dental Plaque Index; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D009067:Mouthwashes; D031339:Ocimum; D055815:Young Adult
chemical_list: D009067:Mouthwashes; C010882:chlorhexidine gluconate; D002710:Chlorhexidine