title: Camptothecin-Polysaccharide Co-assembly and Its Controlled Release.
abstract: β-Cyclodextrin modified camptothecin (CPT-CD) was synthesized through esterification reaction and "click chemistry" to greatly improve the solubility of CPT in aqueous solution, and then, a supramolecular nanoparticle was constructed by strong noncovalent interaction between β-cyclodextrin and adamantane and amphiphilic interaction by simply mixing CPT-CD and adamantane modified hyaluronic acid (HA-ADA) together. The obtained nanoparticle had a hydrophilic HA shell, which could target and recognize HA receptors overexpressed on the surface of cancer cells, and a hydrophobic CPT core, which could protect CPT from hydrolyzation. The results of cytotoxicity experiments showed that the nanoparticle we have designed in this work exhibited similar anticancer activities to, but with much lower side effects than, the commercial chemotherapeutic drug CPT in vitro. We believe that this work might provide a strategy for improving the treatment performance of CPT in laboratory and clinical settings.
authors.affiliation: Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) , Tianjin 300071, P. R. China.|School of Chemical Engineering and Technology, Hebei University of Technology , Tianjin 300130, P. R. China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) , Tianjin 300071, P. R. China.
authors.forename: Ying-Ming
authors.initials: YM
authors.lastname: Zhang
authors.affiliation: Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) , Tianjin 300071, P. R. China.
authors.forename: Dizao
authors.initials: D
authors.lastname: Li
authors.affiliation: Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) , Tianjin 300071, P. R. China.
authors.forename: He-Lue
authors.initials: HL
authors.lastname: Sun
authors.affiliation: School of Chemical Engineering and Technology, Hebei University of Technology , Tianjin 300130, P. R. China.
authors.forename: Hong-Xian
authors.initials: HX
authors.lastname: Fan
authors.affiliation: Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) , Tianjin 300071, P. R. China.
authors.forename: Yu
authors.identifier: http://orcid.org/0000-0001-8723-1896
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000218:Adamantane / Q000737:chemistry; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage* / Q000737:chemistry; D002166:Camptothecin / Q000008:administration & dosage* / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000737:chemistry* / Q000493:pharmacokinetics; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry; D004354:Drug Screening Assays, Antitumor; D000067493:Dynamic Light Scattering; D045325:HCT116 Cells / Q000187:drug effects; D006801:Humans; D006820:Hyaluronic Acid / Q000737:chemistry; D051379:Mice; D018625:Microscopy, Atomic Force; D046529:Microscopy, Electron, Transmission; D041681:NIH 3T3 Cells / Q000187:drug effects; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry; D012995:Solubility; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D047392:beta-Cyclodextrins; D006820:Hyaluronic Acid; D000218:Adamantane; D002166:Camptothecin