title: Diagnostic accuracy of intravascular ultrasound-derived minimal lumen area compared with fractional flow reserve.
abstract: BACKGROUND
  The use of fractional flow reserve (FFR) as the gold standard for functional assessment of intermediate coronary stenosis has been well documented. Intracoronary imaging techniques such as intravascular ultrasound (IVUS) have been used for additional coronary lesion resolution and some of its anatomic parameters have been studied as having possible correlation with FFR, particularly IVUS minimal lumen area (MLA). We performed a comprehensive review of the available literature in the area.
  
  
  METHODS
  A Pubmed search was performed for all the literature involving comparison of diagnostic accuracy of IVUS-MLA with FFR.
  
  
  RESULTS
  An extensive description of all the available data regarding IVUS-MLA diagnostic value regarding the FFR of stenotic lesions, for both non-left main (non-LM) and left main (LM) lesions.
  
  
  CONCLUSIONS
  For non-LM lesions IVUS-MLA cutoff values to identify specific FFR thresholds have marked heterogeneity and perform particularly poorly in terms of specificity and positive predictive value. For LM lesions IVUS-MLA performs better and shows a better correlation with FFR, though more data is needed to confirmed that trend.
authors.affiliation: UH Harrington Heart and Vascular Institute, UH University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
authors.forename: Joao P
authors.initials: JP
authors.lastname: Lopes
authors.affiliation: UH Harrington Heart and Vascular Institute, UH University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
authors.forename: Michelle K
authors.initials: MK
authors.lastname: Jordan
authors.affiliation: UH Harrington Heart and Vascular Institute, UH University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
authors.forename: Hiram
authors.initials: H
authors.lastname: Bezerra
authors.affiliation: UH Harrington Heart and Vascular Institute, UH University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
authors.forename: Marco A
authors.initials: MA
authors.lastname: Costa
authors.affiliation: UH Harrington Heart and Vascular Institute, UH University Hospitals Cleveland Medical Center, Cleveland, OH, USA - guilherme.attizzani@uhhospitals.org.
authors.forename: Guilherme
authors.initials: G
authors.lastname: Attizzani
mesh_terms: D023921:Coronary Stenosis / Q000000981:diagnostic imaging* / Q000503:physiopathology; D003331:Coronary Vessels / Q000000981:diagnostic imaging* / Q000503:physiopathology; D053805:Fractional Flow Reserve, Myocardial; D006801:Humans; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014463:Ultrasonography / Q000379:methods