title: [Advances of research on the mechanism of Down syndrome birth at advanced maternal age].
abstract: Down syndrome is caused by partial or complete triplication of genes located on chromosome 21. Its incidence increases dramatically with the age of women. Hypotheses proposed for this have included abnormal homologous recombination, defective spindle assembly, biological aging, reduction of cohesion complexes, endocrine disorders, oocyte selection model, and single nucleotide polymorphisms of genes that maintain chromosome stability, etc. A literature review is provided here.
authors.affiliation: Department of Obstetrics, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, China. shentuzhangbin@163.com.
authors.forename: Nan
authors.initials: N
authors.lastname: Chu
authors.forename: Yueping
authors.initials: Y
authors.lastname: Zhang
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
mesh_terms: D000375:Aging / Q000235:genetics*; D002891:Chromosomes, Human, Pair 21 / Q000235:genetics; D004314:Down Syndrome / Q000235:genetics*; D005260:Female; D006801:Humans; D008423:Maternal Age; D009865:Oocytes / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide / Q000235:genetics