title: Ultrasensitive GSH-Responsive Ditelluride-Containing Poly(ether-urethane) Nanoparticles for Controlled Drug Release.
abstract: A novel ultrasensitive redox-responsive system for the controlled release of doxorubicin (DOX) was fabricated by ditelluride-containing poly(ether-urethane) copolymers. In this study, the ditelluride group was introduced for the first time into water-soluble copolymers used for drug delivery. Doxorubicin loaded in the copolymer nanoparticles can be released in a controlled manner through the cleavage of ditelluride bonds by glutathione (GSH). The ditelluride-containing poly(ether-urethane) nanoparticles were demonstrated to be biocompatible as drug delivery vehicles, therefore opening a new avenue in drug delivery systems for chemotherapy. Furthermore, the in vitro and in vivo studies revealed that the DOX-loaded ditelluride-containing poly(ether-urethane) nanoparticles exhibited efficient uptake in cancer cells, specific tumor targeting and antitumor activity, indicating their excellent potential as novel nanocarriers for drug delivery and cancer therapy.
authors.affiliation: School for Radiological & Interdisciplinary sciences (RAD-X) and School of Radiation Medicine and Protection, Soochow University , Suzhou, 215123 Jiangsu, China.|Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions , 199 Renai Road, Suzhou Industrial Park, Suzhou, 215123 Jiangsu, China.
authors.forename: Yangyun
authors.identifier: http://orcid.org/0000-0002-2058-7553
authors.initials: Y
authors.lastname: Wang
authors.affiliation: The Second Affiliated Hospital of Soochow University , 1055 Sanxiang Road, Suzhou, 215004 Jiangsu, China.
authors.forename: Lina
authors.initials: L
authors.lastname: Zhu
authors.affiliation: School for Radiological & Interdisciplinary sciences (RAD-X) and School of Radiation Medicine and Protection, Soochow University , Suzhou, 215123 Jiangsu, China.|Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions , 199 Renai Road, Suzhou Industrial Park, Suzhou, 215123 Jiangsu, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
authors.affiliation: The Second Affiliated Hospital of Soochow University , 1055 Sanxiang Road, Suzhou, 215004 Jiangsu, China.
authors.forename: Liubing
authors.initials: L
authors.lastname: Li
authors.affiliation: The Second Affiliated Hospital of Soochow University , 1055 Sanxiang Road, Suzhou, 215004 Jiangsu, China.
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Lu
authors.affiliation: The Second Affiliated Hospital of Soochow University , 1055 Sanxiang Road, Suzhou, 215004 Jiangsu, China.
authors.forename: Liqin
authors.initials: L
authors.lastname: Shen
authors.affiliation: School for Radiological & Interdisciplinary sciences (RAD-X) and School of Radiation Medicine and Protection, Soochow University , Suzhou, 215123 Jiangsu, China.|Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions , 199 Renai Road, Suzhou Industrial Park, Suzhou, 215123 Jiangsu, China.
authors.forename: Leshuai W
authors.initials: LW
authors.lastname: Zhang
mesh_terms: D004317:Doxorubicin; D004337:Drug Carriers; D016503:Drug Delivery Systems; D065546:Drug Liberation; D004986:Ether; D004987:Ethers; D006863:Hydrogen-Ion Concentration; D053758:Nanoparticles; D014520:Urethane
chemical_list: D004337:Drug Carriers; D004987:Ethers; D004986:Ether; D014520:Urethane; D004317:Doxorubicin
keywords: chemotherapy; controlled drug delivery; ditelluride-containing poly(ether-urethane)s; redox-responsive nanoparticles; ultrasensitive nanocarriers