title: Thermal sensitivity and protein anti-adsorption of hydroxypropyl cellulose-g- poly(2-(methacryloyloxy) ethyl phosphorylcholine).
abstract: Zwitterionic graft copolymers, hydroxypropyl cellulose graft poly(2-(methacryloyloxy) ethyl phosphorylcholine) (HPC-g-PMPC) with well-defined architecture were synthesized by atom transfer radical polymerization (ATRP). The self-assembly behaviors and thermal sensitivity of HPC-g-PMPC copolymers and their correlations with graft density and side chain length were investigated in details. HPC-g-PMPC copolymers can self-assemble into spherical aggregate structure above the critical aggregation concentration (CAC) at room temperature. Meanwhile, the size of the aggregates mainly depended on the graft density. The obtained aggregates were thermal sensitive and their low critical solution temperature (LCST) was efficiently regulated by varying the graft density. Above the LCST, the aggregates were transferred into aggregates with core-shell structure, in which the HPC rich core was stabilized by the PMPC rich shell. The interaction between the HPC-g-PMPC aggregates and BSA was investigated. The results indicated that the anti-adsorption of BSA on the aggregates surface depended on the length and graft density of the PMPC zwitterionic side chains.
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Beijing National Laboratory of Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; Key Laboratory of Rubber-Plastics, Ministry of Education, School of Polymer Science and Engineering, Qingdao University of Science and Technology, Qingdao 266042, China. Electronic address: cijiliang9910@126.com.
authors.forename: Jiliang
authors.initials: J
authors.lastname: Ci
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Beijing National Laboratory of Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. Electronic address: hlkang@iccas.ac.cn.
authors.forename: Hongliang
authors.initials: H
authors.lastname: Kang
authors.affiliation: Key Laboratory of Rubber-Plastics, Ministry of Education, School of Polymer Science and Engineering, Qingdao University of Science and Technology, Qingdao 266042, China. Electronic address: liuchenguang@qust.edu.cn.
authors.forename: Chenguang
authors.initials: C
authors.lastname: Liu
authors.affiliation: Key Laboratory of Rubber-Plastics, Ministry of Education, School of Polymer Science and Engineering, Qingdao University of Science and Technology, Qingdao 266042, China. Electronic address: aihuahe@iccas.ac.cn.
authors.forename: Aihua
authors.initials: A
authors.lastname: He
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Beijing National Laboratory of Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. Electronic address: rgliu@iccas.ac.cn.
authors.forename: Ruigang
authors.initials: R
authors.lastname: Liu
mesh_terms: D000327:Adsorption; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D008689:Methacrylates; D010767:Phosphorylcholine / Q000737:chemistry*; D011108:Polymers; D013696:Temperature
chemical_list: D008689:Methacrylates; D011108:Polymers; D010767:Phosphorylcholine; D002482:Cellulose; C008079:hydroxypropylcellulose
keywords: Hydroxypropyl cellulose; LCST; Self-assembly; Thermal sensitivity; Zwitterionic polymers