title: The development of non-coding RNA ontology.
abstract: Identification of non-coding RNAs (ncRNAs) has been significantly improved over the past decade. On the other hand, semantic annotation of ncRNA data is facing critical challenges due to the lack of a comprehensive ontology to serve as common data elements and data exchange standards in the field. We developed the Non-Coding RNA Ontology (NCRO) to handle this situation. By providing a formally defined ncRNA controlled vocabulary, the NCRO aims to fill a specific and highly needed niche in semantic annotation of large amounts of ncRNA biological and clinical data.
authors.affiliation: School of Computing, University of South Alabama, Shelby Hall, Room 1123, 150 Jaguar Drive Mobile, AL 36688, USA, huang@southalabama.edu.
authors.forename: Jingshan
authors.initials: J
authors.lastname: Huang
authors.affiliation: Department of Biomedical Informatics, University of Utah School of Medicine, Salt Lake City, Utah, USA, keilbeck@genetics.utah.edu.
authors.forename: Karen
authors.initials: K
authors.lastname: Eilbeck
authors.affiliation: University at Buffalo - SUNY, Buffalo, New York 14260, USA, phismith@buffalo.edu.
authors.forename: Barry
authors.initials: B
authors.lastname: Smith
authors.affiliation: Jackson Laboratory, Bar Harbor, Connecticut 04609, USA, Judith.Blake@jax.org.
authors.forename: Judith A
authors.initials: JA
authors.lastname: Blake
authors.affiliation: Computer and Information Science Department, University of Oregon, Eugene, Oregon 97403, USA, dou@cs.uoregon.edu.
authors.forename: Dejing
authors.initials: D
authors.lastname: Dou
authors.affiliation: Miracle Query, Inc., Eugene, Oregon 97405, USA, weili.huang@miraclequery.com.
authors.forename: Weili
authors.initials: W
authors.lastname: Huang
authors.affiliation: Georgetown University Medical Center, Washington DC 20007, USA, dan5@georgetown.edu.
authors.forename: Darren A
authors.initials: DA
authors.lastname: Natale
authors.affiliation: University at Buffalo - SUNY, Buffalo, New York 14260, USA, alanruttenberg@gmail.com.
authors.forename: Alan
authors.initials: A
authors.lastname: Ruttenberg
authors.affiliation: Department of Electrical Engineering and Computer Science, University of Kansas, Lawrence, Kansas 66045, USA, jhuan@ittc.ku.edu.
authors.forename: Jun
authors.initials: J
authors.lastname: Huan
authors.affiliation: Division of Biomedical Statistics and Informatics, College of Medicine at Mayo Clinic, Rochester, Minnesota 55905, USA, Zimmermann.Michael@mayo.edu.
authors.forename: Michael T
authors.initials: MT
authors.lastname: Zimmermann
authors.affiliation: Division of Biomedical Statistics and Informatics, College of Medicine at Mayo Clinic, Rochester, Minnesota 55905, USA, Jiang.Guoqian@mayo.edu.
authors.forename: Guoqian
authors.initials: G
authors.lastname: Jiang
authors.affiliation: Data Coordination and Integration Center, University of Miami, Miami, Florida 33146, USA, linikujp@gmail.com.
authors.forename: Yu
authors.initials: Y
authors.lastname: Lin
authors.affiliation: Endocrinology Department, Kunming Medical University, Kunming, Yunnan, 650032 China, wu.bin.kmu@qq.com.
authors.forename: Bin
authors.initials: B
authors.lastname: Wu
authors.affiliation: School of Computing, University of South Alabama, Mobile, Alabama 36688, USA, hjs1221@jagmail.southalabama.edu.
authors.forename: Harrison J
authors.initials: HJ
authors.lastname: Strachan
authors.affiliation: Computer and Information Science, University of Oregon, Eugene, Oregon 97403, USA, nisansa@cs.uoregon.edu.
authors.forename: Nisansa
authors.initials: N
authors.lastname: de Silva
authors.affiliation: School of Computing, University of South Alabama, Mobile, Alabama 36688, USA, mk1530@jagmail.southalabama.edu.
authors.forename: Mohan Vamsi
authors.initials: MV
authors.lastname: Kasukurthi
authors.affiliation: School of Computing, University of South Alabama, Mobile, Alabama 36688, USA, vj1521@jagmail.southalabama.edu.
authors.forename: Vikash Kumar
authors.initials: VK
authors.lastname: Jha
authors.affiliation: Lab Animal Medicine, Microbiology, Immunology and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA, yongqunh@med.umich.edu.
authors.forename: Yongqun
authors.initials: Y
authors.lastname: He
authors.affiliation: Department of Computer Science, University of Central Florida, Orlando, Florida 32816, USA, shzhang@cs.ucf.edu.
authors.forename: Shaojie
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Cancer Biology, Washington University in St. Louis, St. Louis, Missouri 63130, USA, xwang@radonc.wustl.edu.
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Wang
authors.affiliation: Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama 36604, USA, zixingliu@health.southalabama.edu.
authors.forename: Zixing
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Biology, University of South Alabama, Mobile, Alabama 36688, USA, borchert@southalabama.edu.
authors.forename: Glen M
authors.initials: GM
authors.lastname: Borchert
authors.affiliation: Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama 36604, USA, mtan@health.southalabama.edu.
authors.forename: Ming
authors.initials: M
authors.lastname: Tan
keywords: bio-ontologies; domain ontology; non-coding RNA; ontology development; reference ontology; semantic data annotation