title: Herpesviruses and Their Host Cells: A Successful Liaison.
abstract: During a long history of coevolution, herpesviruses have reached a fine-tuned balance with their hosts, allowing them to successfully persist and spread to new hosts without causing too much damage. Only under certain circumstances, as in neonates or immunocompromised individuals, they may cause serious diseases. The delicate balance between herpesviruses and their hosts results from interactions of a great variety of viral and cellular factors which together shape the tropism for a particular host, tissue, or cell. Understanding these interactions will provide insight into the viral life cycle and cell biology in general. Moreover, it will also facilitate comprehension of herpesvirus pathogenesis, enabling the development of new strategies to combat herpesviruses in cases where they cause disease.
authors.affiliation: Max von Pettenkofer-Institute, Department of Virology, Ludwig-Maximilians-University Munich, Pettenkoferstraße 9A, D-80336 Munich, Germany.
authors.forename: Barbara
authors.initials: B
authors.lastname: Adler
authors.affiliation: Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH), Institute of Lung Biology and Disease, Comprehensive Pneumology Center, Ingolstädter Landstr. 1, D-85764 Neuherberg, Germany.
authors.forename: Christine
authors.initials: C
authors.lastname: Sattler
authors.affiliation: Comprehensive Pneumology Center, Research Unit Lung Repair and Regeneration, Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH), Marchioninistrasse 25, D-81377 Munich, Germany, and University Hospital Grosshadern, Ludwig-Maximilians-University, Munich, Germany(4). Electronic address: h.adler@helmholtz-muenchen.de.
authors.forename: Heiko
authors.initials: H
authors.lastname: Adler
mesh_terms: D006564:Herpesviridae / Q000502:physiology*; D006566:Herpesviridae Infections / Q000635:transmission* / Q000821:virology; D054884:Host-Pathogen Interactions / Q000502:physiology*; D006801:Humans; D056189:Viral Tropism / Q000502:physiology*; D053586:Virus Internalization; D017735:Virus Latency / Q000502:physiology*
keywords: cell and tissue types; herpesviruses; restriction factors; tropism