title: The association of sociodemographic and objectively-assessed disease variables with fatigue in systemic sclerosis: an analysis of 785 Canadian Scleroderma Research Group Registry patients.
abstract: Fatigue is prevalent among patients with systemic sclerosis (SSc). To date, studies investigating fatigue in SSc have been hampered by the instruments used to measure fatigue in SSc and have included patient-reported rather than objectively-rated measures of disease. The Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) scale is a validated measure for assessing fatigue in SSc that, compared to other instruments, provides good coverage of the full range of the fatigue spectrum. The objective of this study was to assess sociodemographic and objectively-rated disease-related associates of fatigue, as measured by the FACIT-F, in a large sample of patients with SSc. Fatigue was assessed using the FACIT-F scale. Disease severity was assessed using Medsger's severity scale. Multivariable linear regression was performed to assess the independent associations between sociodemographic and medical variables and fatigue. Among 785 patients, the mean FACIT-F score was 32.2 (SD = 12.1). Being age 40-49 (reference = 60+; standardized regression coefficient (β) = -0.11), less than post-secondary education (β = 0.07), having more medical comorbidities (β = -0.11) and more severe muscle (β = -0.10), gastrointestinal (β = -0.15), lung (β = -0.13), and general system disease severity (β = -0.13) were independently associated with more fatigue (p < 0.05). Fatigue in SSc was independently associated with more severe disease. These data contribute to a better understanding of fatigue in SSc and help inform patient-centered research in SSc.
authors.affiliation: Lady Davis Institute for Medical Research, Jewish General Hospital, 4333 Cote St Catherine Road, Montréal, Québec, H3T 1E4, Canada.|Department of Epidemiology, Biostatistics and Occupational Health, McGill University, 1020 Pine Avenue West, Montréal, Québec, H3A 1A2, Canada.
authors.forename: Brooke
authors.initials: B
authors.lastname: Levis
authors.affiliation: Lady Davis Institute for Medical Research, Jewish General Hospital, 4333 Cote St Catherine Road, Montréal, Québec, H3T 1E4, Canada.|Behavioural Science Institute, Clinical Psychology, Radboud University, Comeniuslaan 4, 6525 HP, Nijmegen, The Netherlands.|Department of Psychiatry, McGill University, 1033 Pine Avenue West, Montréal, Québec, H3A 1A1, Canada.
authors.forename: Linda
authors.initials: L
authors.lastname: Kwakkenbos
authors.affiliation: Lady Davis Institute for Medical Research, Jewish General Hospital, 4333 Cote St Catherine Road, Montréal, Québec, H3T 1E4, Canada.|Department of Medicine, McGill University, 1001 Decarie Boulevard, Montréal, Québec, H4A 3J1, Canada.
authors.forename: Marie
authors.initials: M
authors.lastname: Hudson
authors.affiliation: Lady Davis Institute for Medical Research, Jewish General Hospital, 4333 Cote St Catherine Road, Montréal, Québec, H3T 1E4, Canada.|Department of Medicine, McGill University, 1001 Decarie Boulevard, Montréal, Québec, H4A 3J1, Canada.
authors.forename: Murray
authors.initials: M
authors.lastname: Baron
authors.affiliation: Lady Davis Institute for Medical Research, Jewish General Hospital, 4333 Cote St Catherine Road, Montréal, Québec, H3T 1E4, Canada. brett.thombs@mcgill.ca.|Department of Epidemiology, Biostatistics and Occupational Health, McGill University, 1020 Pine Avenue West, Montréal, Québec, H3A 1A2, Canada. brett.thombs@mcgill.ca.|Department of Psychiatry, McGill University, 1033 Pine Avenue West, Montréal, Québec, H3A 1A1, Canada. brett.thombs@mcgill.ca.|Department of Medicine, McGill University, 1001 Decarie Boulevard, Montréal, Québec, H4A 3J1, Canada. brett.thombs@mcgill.ca.|Department of Psychology, McGill University, 1205 Dr Penfield Avenue, Montréal, Québec, H3A 1B1, Canada. brett.thombs@mcgill.ca.|Department of Educational and Counselling Psychology, McGill University, 3700 McTavish Street, Montréal, Québec, H3A 1Y2, Canada. brett.thombs@mcgill.ca.
authors.forename: Brett D
authors.initials: BD
authors.lastname: Thombs
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002170:Canada; D002908:Chronic Disease; D015897:Comorbidity; D005221:Fatigue / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology*; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012042:Registries; D012219:Rheumatology / Q000379:methods; D012595:Scleroderma, Systemic / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology*; D012720:Severity of Illness Index; D012923:Social Class; D055815:Young Adult
keywords: FACIT-F; Fatigue; Medsger’s disease severity scale; Systemic sclerosis