title: Extraction and encapsulation of prodigiosin in chitosan microspheres for targeted drug delivery.
abstract: The encapsulation of drugs in polymeric materials has brought opportunities to the targeted delivery of chemotherapeutic agents. These polymeric delivery systems are capable of maximizing the therapeutic activity, as well as reducing the side effects of anti-cancer agents. Prodigiosin, a secondary metabolite extracted from the bacteria, Serratia marcescens, exhibits anti-cancer properties. Prodigiosin-loaded chitosan microspheres were prepared via water-in-oil (w/o) emulsion technique, using glutaraldehyde as a cross-linker. The morphologies of the microspheres were studied using scanning electron microscopy. The average sizes of the microspheres were between 40μm and 60μm, while the percentage yields ranged from 42±2% to 55.5±3%. The resulting encapsulation efficiencies were between 66.7±3% and 90±4%. The in-vitro drug release from the microspheres was characterized by zeroth order, first order and Higuchi and Korsmeyer-Peppas models.
authors.affiliation: Department of Materials Science and Engineering, African University of Science and Technology (AUST) Abuja, Federal Capital Territory, Nigeria; Biotechnology and Genetic Engineering Advanced Laboratory, Sheda Science and Technology Complex (SHESTCO), P.M.B 186, Garki, Abuja, Federal Capital Territory, Nigeria.
authors.forename: S O
authors.initials: SO
authors.lastname: Dozie-Nwachukwu
authors.affiliation: Department of Materials Science and Engineering, African University of Science and Technology (AUST) Abuja, Federal Capital Territory, Nigeria; Department of Materials Science and Engineering, Kwara State University, Malete, Nigeria.
authors.forename: Y
authors.initials: Y
authors.lastname: Danyuo
authors.affiliation: Department of Materials Science and Engineering, African University of Science and Technology (AUST) Abuja, Federal Capital Territory, Nigeria; Department of Mechanical and Aerospace Engineering, Princeton University, Princeton, NJ 08544, USA.
authors.forename: J D
authors.initials: JD
authors.lastname: Obayemi
authors.affiliation: Department of Materials Science and Engineering, African University of Science and Technology (AUST) Abuja, Federal Capital Territory, Nigeria; Biotechnology and Genetic Engineering Advanced Laboratory, Sheda Science and Technology Complex (SHESTCO), P.M.B 186, Garki, Abuja, Federal Capital Territory, Nigeria.
authors.forename: O S
authors.initials: OS
authors.lastname: Odusanya
authors.affiliation: Department of Mechanical and Aerospace Engineering, Princeton University, Princeton, NJ 08544, USA.
authors.forename: K
authors.initials: K
authors.lastname: Malatesta
authors.affiliation: Department of Materials Science and Engineering, African University of Science and Technology (AUST) Abuja, Federal Capital Territory, Nigeria; Department of Mechanical and Aerospace Engineering, Princeton University, Princeton, NJ 08544, USA; Princeton Institute of Science and Technology of Materials (PRISM), Bowen Hall, 70 Prospect Street, Princeton, NJ 08544, USA. Electronic address: soboyejo@princeton.edu.
authors.forename: W O
authors.initials: WO
authors.lastname: Soboyejo
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000493:pharmacokinetics / Q000494:pharmacology; D016503:Drug Delivery Systems / Q000379:methods*; D008863:Microspheres; D011353:Prodigiosin / Q000737:chemistry / Q000302:isolation & purification / Q000493:pharmacokinetics / Q000494:pharmacology; D012706:Serratia marcescens / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D011353:Prodigiosin
keywords: Chitosan; Drug release; Encapsulation; Microspheres; Prodigiosin; Serratia marcescens