title: Esterase Activated Carbonyl Sulfide/Hydrogen Sulfide (H2S) Donors.
abstract: Hydrogen sulfide (H2S) is a mediator of a number of cellular processes, and modulating cellular levels of this gas has emerged as an important therapeutic area. Localized generation of H2S is thus very useful but highly challenging. Here, we report pivaloyloxymethyl-based carbonothioates and carbamothioates that are activated by the enzyme, esterase, to generate carbonyl sulfide (COS), which is hydrolyzed to H2S.
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research Pune , Dr. Homi Bhabha Road, Pashan Pune 411 008, Maharashtra, India.
authors.forename: Preeti
authors.initials: P
authors.lastname: Chauhan
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research Pune , Dr. Homi Bhabha Road, Pashan Pune 411 008, Maharashtra, India.
authors.forename: Prerona
authors.initials: P
authors.lastname: Bora
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research Pune , Dr. Homi Bhabha Road, Pashan Pune 411 008, Maharashtra, India.
authors.forename: Govindan
authors.initials: G
authors.lastname: Ravikumar
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research Pune , Dr. Homi Bhabha Road, Pashan Pune 411 008, Maharashtra, India.
authors.forename: Swetha
authors.initials: S
authors.lastname: Jos
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research Pune , Dr. Homi Bhabha Road, Pashan Pune 411 008, Maharashtra, India.
authors.forename: Harinath
authors.identifier: 0000-0002-7267-0906
authors.initials: H
authors.lastname: Chakrapani