title: The roles of bacteriophages in membrane-based water and wastewater treatment processes: A review.
abstract: Membrane filtration processes have been widely applied in water and wastewater treatment for many decades. Concerns related to membrane treatment effectiveness, membrane lifespan, and membrane fouling control have been paid great attention. To achieve sustainable membrane operation with regards to low energy and maintenance cost, monitoring membrane performance and applying suitable membrane control strategies are required. As the most abundant species in water and wastewater, bacteriophages have shown great potential to be employed in membrane processes as (1) indicators to assess membrane performance considering their similar properties to human pathogenic waterborne viruses; (2) surrogate particles to monitor membrane integrity due to their nano-sized nature; and (3) biological agents to alleviate membrane fouling because of their antimicrobial properties. This study aims to provide a comprehensive review on the roles of bacteriophages in membrane-based water and wastewater treatment processes, with focuses on their uses for membrane performance examination, membrane integrity monitoring, and membrane biofouling control. The advantages, limitations, and influencing factors for bacteriophage-based applications are reported. Finally, the challenges and prospects of bacteriophage-based applications in membrane processes for water treatment are highlighted.
authors.affiliation: Singapore Membrane Technology Centre, Nanyang Environment and Water Research Institute, Nanyang Technological University, 1 Cleantech Loop, CleanTech One #06-08, 637141, Singapore. Electronic address: wubing@ntu.edu.sg.
authors.forename: Bing
authors.initials: B
authors.lastname: Wu
authors.affiliation: Singapore Membrane Technology Centre, Nanyang Environment and Water Research Institute, Nanyang Technological University, 1 Cleantech Loop, CleanTech One #06-08, 637141, Singapore; School of Civil and Environmental Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798, Singapore. Electronic address: rwang@ntu.edu.sg.
authors.forename: Rong
authors.initials: R
authors.lastname: Wang
authors.affiliation: Singapore Membrane Technology Centre, Nanyang Environment and Water Research Institute, Nanyang Technological University, 1 Cleantech Loop, CleanTech One #06-08, 637141, Singapore; School of Civil and Environmental Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798, Singapore.
authors.forename: Anthony G
authors.initials: AG
authors.lastname: Fane
mesh_terms: D001435:Bacteriophages; D057219:Biofouling; D019149:Bioreactors; D005374:Filtration; D008567:Membranes, Artificial; D062065:Wastewater; D014867:Water; D018508:Water Purification
chemical_list: D008567:Membranes, Artificial; D062065:Wastewater; D014867:Water
keywords: Biofouling control; Membrane filtration; Membrane integrity; Surrogate particles; Virus indicator