title: Enantioselective α-Arylation of O-Carbamates via Sparteine-Mediated Lithiation and Negishi Cross-Coupling.
abstract: A general and highly enantioselective arylation of carbamates derived from primary alcohols was developed by combining Hoppe's sparteine-mediated asymmetric lithiation with Negishi cross-coupling. Coupled with Aggarwal's lithiation-borylation sequence, the current method provides a short and divergent access to a variety of enantioenriched secondary and tertiary benzylic alcohols.
authors.affiliation: University of Basel , Department of Chemistry, St. Johanns-Ring 19, CH-4056 Basel, Switzerland.
authors.forename: Titouan
authors.initials: T
authors.lastname: Royal
authors.affiliation: University of Basel , Department of Chemistry, St. Johanns-Ring 19, CH-4056 Basel, Switzerland.
authors.forename: Yann
authors.initials: Y
authors.lastname: Baumgartner
authors.affiliation: University of Basel , Department of Chemistry, St. Johanns-Ring 19, CH-4056 Basel, Switzerland.
authors.forename: Olivier
authors.identifier: 0000-0002-0847-8493
authors.initials: O
authors.lastname: Baudoin