title: Langerhans Cell Histiocytosis and Langerhans Cell Sarcoma: Current Understanding and Differential Diagnosis.
abstract: Langerhans cell (LC) histiocytosis (LCH) and LC sarcoma (LCS) are proliferative processes consisting of cells having morphologic and phenotypic features of Langerhans cells (LCs), although the latter may have lost some of these features. Because neoplastic nature of LCH as well as LCS is more likely by recent studies, a category of LC hyperplasia can be better characterized. LCH and LCS are rarely seen in daily pathology practice, but it is important to accurately characterize these lesions. For this purpose, an outline covering proliferations of LC and related cells was constructed. The scheme of this outline is based especially on evaluating borderline lesions, neoplastic trans-differentiation, and degree of similarity with the normal counter-parts. In addition, the organization and update of the current classification scheme for histiocytic and dendritic-cell proliferations is presented.
authors.affiliation: Department of Laboratory Medicine, Japan Baptist Hospital.
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Nakamine
authors.forename: Mitsunori
authors.initials: M
authors.lastname: Yamakawa
authors.forename: Tadashi
authors.initials: T
authors.lastname: Yoshino
authors.forename: Takaya
authors.initials: T
authors.lastname: Fukumoto
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Enomoto
authors.forename: Itaru
authors.initials: I
authors.lastname: Matsumura
mesh_terms: D003937:Diagnosis, Differential; D006646:Histiocytosis, Langerhans-Cell / Q000145:classification* / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D054752:Langerhans Cell Sarcoma / Q000145:classification* / Q000175:diagnosis* / Q000628:therapy