title: Dietary supplement comprised of β-carotene, vitamin C, vitamin E, and magnesium: failure to prevent music-induced temporary threshold shift.
abstract: This study examined potential prevention of music-induced temporary threshold shift (TTS) in normal-hearing participants. A dietary supplement composed of β-carotene, vitamins C and E, and magnesium was assessed using a randomized, placebo-controlled, double-blind study design. Dosing began 3 days prior to the music exposure with the final dose consumed approximately 30-min pre-exposure. There were no group differences in post-exposure TTS or music-induced decreases in distortion product otoacoustic emission (DPOAE) amplitude. Transient tinnitus was more likely to be reported by the treatment group, but there were no group differences in perceived loudness or bothersomeness. All subjects were monitored until auditory function returned to pre-exposure levels. Taken together, this supplement had no effect on noise-induced changes in hearing. Recommendations for future clinical trials are discussed.
authors.affiliation: School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, Tex.
authors.forename: C G
authors.initials: CG
authors.lastname: Le Prell
authors.affiliation: Department of Speech, Language, and Hearing Sciences, University of Florida, Gainesville, Fla.
authors.forename: A
authors.initials: A
authors.lastname: Fulbright
authors.affiliation: Department of Otolaryngology and Communicative Sciences, University of Mississippi Medical Center, Jackson, Miss.
authors.forename: C
authors.initials: C
authors.lastname: Spankovich
authors.affiliation: Department of Speech, Language, and Hearing Sciences, University of Florida, Gainesville, Fla.
authors.forename: S K
authors.initials: SK
authors.lastname: Griffiths
authors.affiliation: School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, Tex.
authors.forename: E
authors.initials: E
authors.lastname: Lobarinas
authors.affiliation: Department of Surgery, Southern Illinois University School of Medicine, Springfield, Ill.
authors.forename: K C M
authors.initials: KC
authors.lastname: Campbell
authors.affiliation: Department of Otolaryngology, University of Florida, Gainesville, Fla.
authors.forename: P J
authors.initials: PJ
authors.lastname: Antonelli
authors.affiliation: Department of Otolaryngology, University of Michigan, Ann Arbor, Mich.
authors.forename: G E
authors.initials: GE
authors.lastname: Green
authors.affiliation: Department of Biostatistics, University of Michigan, Ann Arbor, Mich.
authors.forename: K
authors.initials: K
authors.lastname: Guire
authors.affiliation: Department of Otolaryngology, University of Michigan, Ann Arbor, Mich.
authors.forename: J M
authors.initials: JM
authors.lastname: Miller
keywords: digital audio player; distortion product otoacoustic emission; magnesium; temporary threshold shift; tinnitus; vitamin C; vitamin E; β-carotene