title: F-Nucleophilic-Addition-Induced Allylic Alkylation.
abstract: Herein we present a novel strategy based on palladium-catalyzed allylic alkylation by taking advantage of the nucleophilic addition of external fluoride onto gem-difluoroalkenes as the initiation step. The merit of this protocol is highly appealing, as it enables a formal allylation of trifluoroethylarene derivatives through the in situ generation of β-trifluorocarbanions, which otherwise are deemed to be problematic in deprotonative allylation. Furthermore, this strategy distinguishes itself by high modularity, operational simplicity, and wide substrate scope with respect to allyl carbonates, giving rise to a broad array of homoallyltrifluoromethane derivatives, which otherwise would not be easily obtained using existing synthetic methods.
authors.affiliation: Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University , 30 South Puzhu Road, Nanjing 211816, P. R. China.|Department of Chemistry, University of Science and Technology of China , Hefei, Anhui 230026, P. R. China.
authors.forename: Panpan
authors.initials: P
authors.lastname: Tian
authors.affiliation: Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University , 30 South Puzhu Road, Nanjing 211816, P. R. China.
authors.forename: Cheng-Qiang
authors.initials: CQ
authors.lastname: Wang
authors.affiliation: Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University , 30 South Puzhu Road, Nanjing 211816, P. R. China.|Department of Chemistry, University of Science and Technology of China , Hefei, Anhui 230026, P. R. China.
authors.forename: Sai-Hu
authors.initials: SH
authors.lastname: Cai
authors.affiliation: Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University , 30 South Puzhu Road, Nanjing 211816, P. R. China.|Department of Chemistry, University of Science and Technology of China , Hefei, Anhui 230026, P. R. China.
authors.forename: Shengjin
authors.initials: S
authors.lastname: Song
authors.affiliation: Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University , 30 South Puzhu Road, Nanjing 211816, P. R. China.
authors.forename: Lu
authors.initials: L
authors.lastname: Ye
authors.affiliation: Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University , 30 South Puzhu Road, Nanjing 211816, P. R. China.
authors.forename: Chao
authors.initials: C
authors.lastname: Feng
authors.affiliation: Department of Chemistry, University of Science and Technology of China , Hefei, Anhui 230026, P. R. China.|Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University , Singapore 637616.
authors.forename: Teck-Peng
authors.initials: TP
authors.lastname: Loh