title: Glypican-3-Expressing Hepatocellular Carcinoma in a Non-Cirrhotic Patient with Nonalcoholic Steatohepatitis: Case Report and Literature Review.
abstract: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Nonalcoholic steatohepatitis (NASH) is now considered as the major cause of cryptogenic cirrhosis, which can progress to HCC. Glypican-3 is a member of the Heparan Sulfate Proteoglycan (HSP) family that plays a role in cell growth, differentiation, and migration. Glypican-3 is significantly up-regulated in a majority of HCCs compared to normal and benign liver samples. Glypican-3 protein is detectable in around 40-53% of HCC patients whereas it is not detectable in the serum of healthy individuals. There are several reports of HCC arising in the setting of non-cirrhotic NASH. This report describes a case of HCC that expressed Glypican-3 and arose in a 47-year-old female with noncirrhotic NASH.
authors.affiliation: College of Medicine, University of Dammam, Consultant Hepatologist and Gastroenterologist, Division of Gastroenterology, Department of Internal Medicine, King Fahad Hospital of the University, Saudi Arabia; Department of Internal Medicine, Division of Gastroenterology & Multiorgan Transplant Programme, King Fahad Specialist Hospital, Dammam, Saudi Arabia.
authors.forename: Mona H
authors.initials: MH
authors.lastname: Ismail
keywords: Glypican-3; Hepatocellular carcinoma; Nonalcoholic steatohepatitis; Noncirrhotic