title: Relationship between Serum Inflammatory Biomarkers and Thrombus Characteristics in Patients with ST Segment Elevation Myocardial Infarction.
abstract: To compare angiographic and optical coherence tomography (OCT) data pertinent to thrombi, along with the histologic characteristics of aspirated thrombi in patients presenting with ST elevation myocardial infarction (STEMI) with or without inflammation, as assessed by C-reactive protein (CRP) and myeloperoxidase (MPO).
  
  
  
  In the OCTAVIA (Optical Coherence Tomography Assessment of Gender Diversity in Primary Angioplasty) study, 140 patients with STEMI referred for primary percutaneous intervention were enrolled. The patients underwent OCT assessment of the culprit vessel, along with blood sampling of CRP and MPO, and histologic analysis of the thrombus.
  
  
  
  Biomarkers were available for 129 patients, and histology and immunohistochemistry of the thrombi were available for 78 patients. Comparisons were made using the median thresholds of CRP and MPO (2.08 mg/L and 604.124 ng/mL, respectively). There was no correlation between CRP and MPO levels in the whole population (p = 0.685). Patients with high CRP levels had higher thrombus grades and more frequent TIMI flow 0/1 compared with those with low CRP levels (5 [1st quartile 3; 3rd quartile 5] vs. 3.5 mg/L [1; 5], p = 0.007, and 69.3 vs. 48.5%, p = 0.04, respectively). Patients with high MPO levels more commonly had early thrombi than had those with low MPO levels (42.5 vs. 20.0%, p = 0.04).
  
  
  
  CRP and MPO were not correlated in STEMI patients, possibly reflecting different pathogenic mechanisms, with CRP more related to thrombus burden and MPO to thrombus age.
authors.affiliation: Institute of Cardiology, Catholic University of the Sacred Heart, Rome, Italy.
authors.forename: Giampaolo
authors.initials: G
authors.lastname: Niccoli
authors.forename: Alberto
authors.initials: A
authors.lastname: Menozzi
authors.forename: Davide
authors.initials: D
authors.lastname: Capodanno
authors.forename: Carlo
authors.initials: C
authors.lastname: Trani
authors.forename: Vasile
authors.initials: V
authors.lastname: Sirbu
authors.forename: Massimo
authors.initials: M
authors.lastname: Fineschi
authors.forename: Chiara
authors.initials: C
authors.lastname: Zara
authors.forename: Filippo
authors.initials: F
authors.lastname: Crea
authors.forename: Daniela
authors.initials: D
authors.lastname: Trabattoni
authors.forename: Francesco
authors.initials: F
authors.lastname: Saia
authors.forename: Elena
authors.initials: E
authors.lastname: Ladich
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Biondi Zoccai
authors.forename: Guilherme
authors.initials: G
authors.lastname: Attizzani
authors.forename: Giulio
authors.initials: G
authors.lastname: Guagliumi
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D017023:Coronary Angiography; D003328:Coronary Thrombosis / Q000097:blood* / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention; D009195:Peroxidase / Q000097:blood*; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D000072657:ST Elevation Myocardial Infarction / Q000209:etiology / Q000601:surgery*; D041623:Tomography, Optical Coherence
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein; D009195:Peroxidase