title: PPy@MIL-100 Nanoparticles as a pH- and Near-IR-Irradiation-Responsive Drug Carrier for Simultaneous Photothermal Therapy and Chemotherapy of Cancer Cells.
abstract: A medical nanoplatform with small size, low cost, biocompatibility, good biodegradability, and, in particular, multifunctionality has attracted much attention in the exploration of novel therapeutic methodologies. As an emerging material of self-assembled porous structure, metal-organic frameworks (MOFs) have high expectations because of their special properties compared to traditional porous materials. Therefore, integration of MOFs and functional materials is leading to the creation of new multifunctional composites/hybrids. Photothermal therapy (PTT), using near-IR (NIR) laser-absorbing nanomaterials as PTT agents, has shown encouraging therapeutic effects to photothermally ablate tumors. However, the most of widely used PTT agents are inorganic materials and nonbiodegradable. Herein, uniform polypyrrole (PPy) nanoparticles (NPs) with good biodegradability were synthesized by a microemulsion method. The PPy NPs were further coated with the mesoporous iron-based MOF structure MIL-100 by interaction between PPy NPs and MIL-100 precursors at room temperature. As a multifunctional nanoplatform, an anticancer drug could easily be loaded into the mesopores of the MIL-100 shell. The PPy core, as an organic photothermal agent, is able to photothermally ablate cancer cells and improve the efficacy of chemotherapy under NIR irradiation. The composites showed an outstanding in vivo synergistic anticancer capacity. Our work could encourage further study in the construction of a synergetic system using MOFs and organic PTT agents.
authors.affiliation: National Engineering Research Center for Biomaterials, Sichuan University , Sichuan, Chengdu 610064, P. R. China.
authors.forename: Yu-Da
authors.initials: YD
authors.lastname: Zhu
authors.affiliation: National Engineering Research Center for Biomaterials, Sichuan University , Sichuan, Chengdu 610064, P. R. China.
authors.forename: Su-Ping
authors.initials: SP
authors.lastname: Chen
authors.affiliation: National Engineering Research Center for Biomaterials, Sichuan University , Sichuan, Chengdu 610064, P. R. China.
authors.forename: Huan
authors.initials: H
authors.lastname: Zhao
authors.affiliation: National Engineering Research Center for Biomaterials, Sichuan University , Sichuan, Chengdu 610064, P. R. China.
authors.forename: You
authors.initials: Y
authors.lastname: Yang
authors.affiliation: National Engineering Research Center for Biomaterials, Sichuan University , Sichuan, Chengdu 610064, P. R. China.
authors.forename: Xiao-Qin
authors.initials: XQ
authors.lastname: Chen
authors.affiliation: National Engineering Research Center for Biomaterials, Sichuan University , Sichuan, Chengdu 610064, P. R. China.
authors.forename: Jing
authors.initials: J
authors.lastname: Sun
authors.affiliation: National Engineering Research Center for Biomaterials, Sichuan University , Sichuan, Chengdu 610064, P. R. China.
authors.forename: Hong-Song
authors.identifier: http://orcid.org/0000-0003-3812-9208
authors.initials: HS
authors.lastname: Fan
authors.affiliation: National Engineering Research Center for Biomaterials, Sichuan University , Sichuan, Chengdu 610064, P. R. China.
authors.forename: Xing-Dong
authors.initials: XD
authors.lastname: Zhang
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry*; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry* / Q000528:radiation effects; D005260:Female; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006979:Hyperthermia, Induced / Q000379:methods*; D007259:Infrared Rays; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry* / Q000528:radiation effects; D010789:Phototherapy / Q000379:methods*; D011108:Polymers / Q000008:administration & dosage / Q000737:chemistry*; D011758:Pyrroles / Q000008:administration & dosage / Q000737:chemistry*; D002583:Uterine Cervical Neoplasms / Q000628:therapy
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D011108:Polymers; D011758:Pyrroles; C067635:polypyrrole; D004317:Doxorubicin
keywords: MIL-100; drug delivery; metal−organic framework; multifunctional hybrids; photothermal therapy; polypyrrole