title: Potential Links between Cytoskeletal Disturbances and Electroneurophysiological Dysfunctions Induced in the Central Nervous System by Inorganic Nanoparticles.
abstract: Inorganic nanomaterials have been widely applied in biomedicine. However, several studies have noted that inorganic nanoparticles can enter the brain and induce cytoskeletal remodeling, as well as electrophysiological alterations, which are related to neurodevelopmental disorders and neurodegenerative diseases. The toxic effects of inorganic nanomaterials on the cytoskeleton and electrophysiology are summarized in this review. The relationships between inorganic NPs-induced cytoskeletal and electrophysiological alterations in the central nervous system remain obscure. We propose several potential relationships, including those involving N-methyl-D-aspartate receptor function, ion channels, transient receptor potential channels, and the Rho pathway.
authors.affiliation: Nanfang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: Yiyuan
authors.initials: Y
authors.lastname: Kang
authors.forename: Jia
authors.initials: J
authors.lastname: Liu
authors.forename: Bin
authors.initials: B
authors.lastname: Song
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Feng
authors.forename: Lingling
authors.initials: L
authors.lastname: Ou
authors.forename: Limin
authors.initials: L
authors.lastname: Wei
authors.forename: Xuan
authors.initials: X
authors.lastname: Lai
authors.forename: Longquan
authors.initials: L
authors.lastname: Shao
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000187:drug effects / Q000503:physiopathology*; D003599:Cytoskeleton / Q000378:metabolism*; D055724:Electrophysiological Phenomena; D006801:Humans; D007287:Inorganic Chemicals / Q000633:toxicity*; D053758:Nanoparticles / Q000633:toxicity*; D018377:Neurotransmitter Agents / Q000378:metabolism
chemical_list: D007287:Inorganic Chemicals; D018377:Neurotransmitter Agents