title: Imidacloprid Promotes High Fat Diet-Induced Adiposity and Insulin Resistance in Male C57BL/6J Mice.
abstract: Imidacloprid, a neonicotinoid insecticide widely used in agriculture worldwide, has been reported to promote adipogenesis and cause insulin resistance in vitro. The purpose of the current study was to determine the effects of imidacloprid and its interaction with dietary fat in the development of adiposity and insulin resistance using male C57BL/6J mice. Imidacloprid (0.06, 0.6, or 6 mg/kg bw/day) was mixed in a low-fat (4% w/w) or high-fat (20% w/w) diet and given to mice ad libitum for 12 weeks. Imidacloprid significantly promoted high fat diet-induced body weight gain and adiposity. In addition, imidacloprid treatment with the high fat diet resulted in impaired glucose metabolism. Consistently, there were significant effects of imidacloprid on genes regulating lipid and glucose metabolisms, including the AMP-activated protein kinase-α (AMPKα) pathway in white adipose tissue and liver. These results suggest that imidacloprid may potentiate high fat diet-induced adiposity and insulin resistance in male C57BL/6J mice.
authors.affiliation: Department of Food Science, University of Massachusetts , Amherst, Massachusetts 01003, United States.
authors.forename: Quancai
authors.initials: Q
authors.lastname: Sun
authors.affiliation: Department of Food Science, University of Massachusetts , Amherst, Massachusetts 01003, United States.
authors.forename: Xiao
authors.initials: X
authors.lastname: Xiao
authors.affiliation: Department of Food Science, University of Massachusetts , Amherst, Massachusetts 01003, United States.
authors.forename: Yoo
authors.initials: Y
authors.lastname: Kim
authors.affiliation: Department of Mathematics and Statistics, University of Massachusetts , Amherst, Massachusetts 01003, United States.
authors.forename: Daeyoung
authors.initials: D
authors.lastname: Kim
authors.affiliation: Department of Biological Sciences and Environmental Sciences Program, Southern Illinois University , Edwardsville, Illinois 62026, United States.
authors.forename: Kyoon Sup
authors.initials: KS
authors.lastname: Yoon
authors.affiliation: Department of Veterinary and Animal Sciences, University of Massachusetts , Amherst, Massachusetts 01003, United States.
authors.forename: John M
authors.initials: JM
authors.lastname: Clark
authors.affiliation: Department of Food Science, University of Massachusetts , Amherst, Massachusetts 01003, United States.
authors.forename: Yeonhwa
authors.initials: Y
authors.lastname: Park
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000378:metabolism; D052436:Adipose Tissue, White / Q000378:metabolism; D050154:Adiposity / Q000187:drug effects*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D059305:Diet, High-Fat / Q000009:adverse effects; D006801:Humans; D007093:Imidazoles / Q000009:adverse effects*; D007306:Insecticides / Q000009:adverse effects*; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D000073943:Neonicotinoids; D009574:Nitro Compounds / Q000009:adverse effects*; D009765:Obesity / Q000209:etiology / Q000378:metabolism*; D015430:Weight Gain / Q000187:drug effects
chemical_list: D001786:Blood Glucose; D007093:Imidazoles; D007306:Insecticides; D007328:Insulin; D000073943:Neonicotinoids; D009574:Nitro Compounds; C082359:imidacloprid; D055372:AMP-Activated Protein Kinases
keywords: AMPKα; adiposity; imidacloprid; insulin resistance; neonicotinoids