title: Spectral-Domain Optical Coherence Tomography in Older Patients With History of Retinopathy of Prematurity.
abstract: To characterize the in vivo microstructural features of patients with history of retinopathy of prematurity (ROP).
  
  
  
  A single-center, retrospective imaging case series during which a chart review was performed of consecutive patients with history of ROP who underwent spectral-domain optical coherence tomography (SD-OCT) with or without enhanced depth imaging. Eyes with time-domain OCT, no light perception, or uninterpretable SD-OCT images were excluded. Main outcome measures included best-corrected visual acuity (BCVA) and exploratory SD-OCT findings.
  
  
  
  A total of 186 eyes of 112 patients (mean age: 31.5 years; range: 8 years to 70 years) were imaged. Mean visual acuity was 20/150 (range: 20/20 to light perception). Mean foveal thickness (MFT) and subfoveal choroidal thickness (SCT) measured 270.93 µm ± 56.40 µm and 239.87 µm ± 73.00 µm, respectively. There was a negative correlation between ROP stage and MFT (Rho = -0.19; P = .027), but not with SCT (Rho = -0.03; P = .748). There were negative correlations between BCVA and MFT (Rho = -0.23; P < .01) and SCT (Rho = -0.19; P = .04). Ellipsoid zone (EZ) abnormalities, inner retinal layer thickening, and presence of chorioretinal atrophy were associated with higher ROP stage (P < .001) and poorer visual acuity (Rho = 0.59; P < .001). The presence of retinoschisis (n = 36/186; 19%) was associated with poorer visual acuity (P < .001), but did not correlate with higher ROP stage (P = .17). Epiretinal membrane-like dense hyaloidal organization and vitreoretinal interface abnormalities were seen in 69% (130/186) and 33% (63/186) of eyes, respectively, but were not associated with ROP stage (P = .87) or visual acuity (P = .54). After controlling for EZ abnormalities, foveal hypoplasia, macular schisis, inner retinal thickening, chorioretinal atrophy, and ROP stage, the independent risk factors for poorer visual acuity were EZ abnormalities (Beta = 0.38; P < .001), chorioretinal atrophy (Beta = 0.18; P = .03), and ROP stage (Beta = 0.22; P < .01).
  
  
  
  SD-OCT imaging identified a variety of microstructural abnormalities present in patients with history of ROP. [Ophthalmic Surg Lasers Imaging Retina. 2016;47:1086-1094.].
authors.forename: Aristomenis
authors.initials: A
authors.lastname: Thanos
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Yonekawa
authors.forename: Bozho
authors.initials: B
authors.lastname: Todorich
authors.forename: Natalie
authors.initials: N
authors.lastname: Huang
authors.forename: Kimberly A
authors.initials: KA
authors.lastname: Drenser
authors.forename: George A
authors.initials: GA
authors.lastname: Williams
authors.forename: Michael T
authors.initials: MT
authors.lastname: Trese
authors.forename: Antonio
authors.initials: A
authors.lastname: Capone
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D012160:Retina / Q000473:pathology*; D012178:Retinopathy of Prematurity / Q000175:diagnosis* / Q000503:physiopathology; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods*; D014792:Visual Acuity; D055815:Young Adult