title: [Diagnostic significance of anti-collectin 11 in systemic lupus erythematosus].
abstract: To analyze the role of anti-collectin 11 in the diagnosis of systemic lupus erythematosus (SLE) and in the evaluation of disease activity.
  
  
  
  This was a cross-sectional study. Five groups of patients were enrolled: SLE active (SLE disease activity index-2000,SLEDAI-2000≥9), SLE remission (SLEDAI-2000≤4 and there was no organ involvement), rheumatoid arthritis (RA), primary Sjogren Syndrome (SS) and healthy control (HC). Serum anti-collectin 11 was detected in all the groups by ELISA. One-way ANOVA analysis and LSD-t-test as post-hoc analysis were used to compare the levels of anti-collectin 11 among all the groups. Receiver operating characteristic (ROC) curve and the area under curve (AUC) were used to analyze the value of anti-collectin 11 in the diagnosis of SLE.
  
  
  
  In the study, 30 patients were enrolled in each group, including 13 males and 137 females with an average age of (34±14) years (18-77 years). The age and gender of the other three groups were comparable to the two SLE groups. The difference of serum anti-collectin 11 between the SLE active group and SLE remission group was not statistically significant (88.8±16.8 vs. 89.7±24.7, P=0.896). The level of serum anti-collectin 11 was significantly higher in SLE group (as a whole) (89.1±19.4) than in RA group (49.1±22.0), SS group (56.9±30.1) and HC group (72.7±24.6) (P<0.001, P<0.001, P=0.007, respectively). The AUC was 0.806 for the diagnosis of SLE by serum anti-collectin 11. Further descriptive analysis showed that the positive rate of anti-collectin 11 was very high in the patients of SLE in whom both anti-double-stranded DNA (dsDNA) and Sm antibody were negative. The nervous system and gastrointestinal system involvement were the most common in the patients with positive anti-collectin 11.
  
  
  
  The level of serum anti-collectin 11 was significantly higher in SLE than in RA, SS and HC. anti-collectin 11 antibody had a relatively high value in the diagnosis of SLE and it might have some complementary function in the diagnosis of SLE. It might be a relatively specific autoantibody for SLE.
authors.affiliation: Department of Rheumatolgoy and Immunology, Peking University Third Hospital, Beijing 100191, China.
authors.forename: X L
authors.initials: XL
authors.lastname: Deng
authors.affiliation: Medical and Health Analytical Center, Peking University Health Science Center, Beijing 100191, China.
authors.forename: L J
authors.initials: LJ
authors.lastname: Zhong
authors.affiliation: Department of Rheumatolgoy and Immunology, Peking University Third Hospital, Beijing 100191, China.
authors.forename: L
authors.initials: L
authors.lastname: Sun
authors.affiliation: Department of Rheumatolgoy and Immunology, Peking University Third Hospital, Beijing 100191, China.
authors.forename: C H
authors.initials: CH
authors.lastname: Li
authors.affiliation: Department of Rheumatolgoy and Immunology, Peking University Third Hospital, Beijing 100191, China.
authors.forename: X Y
authors.initials: XY
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear; D001172:Arthritis, Rheumatoid; D001323:Autoantibodies / Q000097:blood; D015415:Biomarkers / Q000097:blood; D037222:Collectins / Q000097:blood* / Q000276:immunology*; D003430:Cross-Sectional Studies; D004247:DNA; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D012859:Sjogren's Syndrome
chemical_list: D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D015415:Biomarkers; C518521:Colec11 protein, human; D037222:Collectins; D004247:DNA