title: Application of Semipermeable Membranes in Glucose Biosensing.
abstract: Glucose biosensors have received significant attention in recent years due to the escalating mortality rate of diabetes mellitus. Although there is currently no cure for diabetes mellitus, individuals living with diabetes can lead a normal life by maintaining tight control of their blood glucose levels using glucose biosensors (e.g., glucometers). Current research in the field is focused on the optimization and improvement in the performance of glucose biosensors by employing a variety of glucose selective enzymes, mediators and semipermeable membranes to improve the electron transfer between the active center of the enzyme and the electrode substrate. Herein, we summarize the different semipermeable membranes used in the fabrication of the glucose biosensor, that result in improved biosensor sensitivity, selectivity, dynamic range, response time and stability.
authors.affiliation: Bioelectronics Laboratory, Department of Computer Science and Electrical Engineering, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA. tank1@umbc.edu.
authors.forename: Tanmay
authors.initials: T
authors.lastname: Kulkarni
authors.affiliation: Bioelectronics Laboratory, Department of Computer Science and Electrical Engineering, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA. gslaught@umbc.edu.
authors.forename: Gymama
authors.initials: G
authors.lastname: Slaughter
keywords: cellulose acetate; glucose biosensor; glucose oxidase; poly(3,4-ethylenedioxythiophene; polypyrrole; pyrolloquinoline quinone glucose dehydrogenase; semipermeable membrane