title: Preattachment Embryos of Domestic Animals: Insights into Development and Paracrine Secretions.
abstract: In mammalian species, endometrial receptivity is driven by maternal factors independently of embryo signals. When pregnancy initiates, paracrine secretions of the preattachment embryo are essential both for maternal recognition and endometrium preparation for implantation and for coordinating development of embryonic and extraembryonic tissues of the conceptus. This review mainly focuses on domestic large animal species. We first illustrate the major steps of preattachment embryo development, including elongation in bovine, ovine, porcine, and equine species. We next highlight conceptus secretions that are involved in the communication between extraembryonic and embryonic tissues, as well as between the conceptus and the endometrium. Finally, we introduce experimental data demonstrating the intimate connection between conceptus secretions and endometrial activity and how adverse events perturbing this interplay may affect the progression of implantation that will subsequently impact pregnancy outcome, postnatal health, and expression of production traits in livestock offspring.
authors.affiliation: UMR BDR, INRA, ENVA, Université Paris Saclay, 78350, Jouy en Josas, France; email: olivier.sandra@inra.fr , gilles.charpigny@inra.fr , laurent.galio@inra.fr , isabelle.hue@inra.fr.
authors.forename: Olivier
authors.initials: O
authors.lastname: Sandra
authors.affiliation: UMR BDR, INRA, ENVA, Université Paris Saclay, 78350, Jouy en Josas, France; email: olivier.sandra@inra.fr , gilles.charpigny@inra.fr , laurent.galio@inra.fr , isabelle.hue@inra.fr.
authors.forename: Gilles
authors.initials: G
authors.lastname: Charpigny
authors.affiliation: UMR BDR, INRA, ENVA, Université Paris Saclay, 78350, Jouy en Josas, France; email: olivier.sandra@inra.fr , gilles.charpigny@inra.fr , laurent.galio@inra.fr , isabelle.hue@inra.fr.
authors.forename: Laurent
authors.initials: L
authors.lastname: Galio
authors.affiliation: UMR BDR, INRA, ENVA, Université Paris Saclay, 78350, Jouy en Josas, France; email: olivier.sandra@inra.fr , gilles.charpigny@inra.fr , laurent.galio@inra.fr , isabelle.hue@inra.fr.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Hue
mesh_terms: D000818:Animals; D000829:Animals, Domestic; D002417:Cattle; D010064:Embryo Implantation; D047108:Embryonic Development; D004717:Endometrium / Q000378:metabolism; D005260:Female; D006736:Horses; D011247:Pregnancy; D011256:Pregnancy Outcome; D011270:Pregnancy, Animal / Q000378:metabolism*; D012756:Sheep; D013552:Swine
keywords: conceptus; endometrium; implantation; pregnancy; signaling; ungulates