title: Acute hepatic effects of low-dose fumonisin B(1) in rats.
abstract: Adult male Wistar rats were enrolled in a study to test the acute hepatic effects of 50 mg/kg fumonisin B1in feed for 5 days. Fumonisin B1depressed growth and feed intake, and absolute and relative liver weight showed a significant increase. The proportions of C17:0, C18:3 n3, C22:5 n3 and C22:6 n3 fatty acids decreased in the hepatic phospholipid fraction. All proportional decreases modified the hepatocellular membrane lipids into a more rigid state. The fatty acid profile modifications were partly compensated for by endogenous glutathione (preventing the formation of conjugated dienes and trienes as initial phase lipid peroxidation indicators), while the enzymatic antioxidant defence system (glutathione peroxidase) was unaltered. In contrast, hepatic malondialdehyde, the cytotoxic product of end-phase lipid peroxidation showed a concentration increase even after 5 days of feeding. The results indicate a rather strong and rapid hepatic effect of FB1, immediately impairing membrane phospholipids, even before the enzymatic antioxidant defence is activated.
authors.affiliation: Institute of Diagnostic Imaging and Radiation Oncology, Kaposvár University , Guba S. u. 40, H-7400 Kaposvár , Hungary.|Hungarian Academy of Sciences - Kaposvár University 'MTA-KE Mycotoxins in the Food Chain' Research Group , Kaposvár , Hungary.
authors.forename: András
authors.initials: A
authors.lastname: Szabó
authors.affiliation: Hungarian Academy of Sciences - Kaposvár University 'MTA-KE Mycotoxins in the Food Chain' Research Group , Kaposvár , Hungary.
authors.forename: Judit
authors.initials: J
authors.lastname: Szabó-Fodor
authors.affiliation: Research Institute for Animal Breeding, Nutrition and Meat Science, National Agricultural Research Centre , Herceghalom , Hungary.
authors.forename: Hedvig
authors.initials: H
authors.lastname: Fébel
authors.affiliation: Department of Nutrition, Faculty of Agricultural and Environmental Sciences, Szent István University , Gödöllő , Hungary.
authors.forename: Miklós
authors.initials: M
authors.lastname: Mézes
authors.affiliation: Institute of Diagnostic Imaging and Radiation Oncology, Kaposvár University , Guba S. u. 40, H-7400 Kaposvár , Hungary.
authors.forename: Imre
authors.initials: I
authors.lastname: Repa
authors.affiliation: Hungarian Academy of Sciences - Kaposvár University 'MTA-KE Mycotoxins in the Food Chain' Research Group , Kaposvár , Hungary.
authors.forename: Melinda
authors.initials: M
authors.lastname: Kovács
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology*; D005227:Fatty Acids / Q000737:chemistry / Q000378:metabolism; D037341:Fumonisins / Q000633:toxicity*; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010743:Phospholipids / Q000737:chemistry / Q000378:metabolism; D051381:Rats
chemical_list: D000975:Antioxidants; D005227:Fatty Acids; D037341:Fumonisins; D010743:Phospholipids; C056933:fumonisin B1
keywords: Fumonisin B1; antioxidants; fatty acids; hepatocellular membrane; oxidative stress; rat