title: Severe excessive daytime sleepiness induced by hydroxyurea.
abstract: Excessive daytime sleepiness (EDS) has been reported with many drugs, either as an extension of a hypnotic effect (e.g. central nervous system depressants) or as an idiosyncratic response of the patient. Here, we report unexpected and severe subjective and objective EDS induced by hydroxyurea therapy, with a favorable outcome after withdrawal. Clinical history, sleep log, polysomnography, and multiple sleep latency tests confirming the absence of other EDS causes are presented.
authors.affiliation: HP2, INSERM U1042, Grenoble Alps University, 38 043, Grenoble Cedex 9, France.|Pharmacovigilance, Grenoble Alps University Hospital, 38 043, Grenoble Cedex 9, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Revol
authors.affiliation: HP2, INSERM U1042, Grenoble Alps University, 38 043, Grenoble Cedex 9, France.|Thorax and Vessels, EFCR, Grenoble Alps University Hospital, 38 043, Grenoble Cedex 9, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Joyeux-Faure
authors.affiliation: Thorax and Vessels, EFCR, Grenoble Alps University Hospital, 38 043, Grenoble Cedex 9, France.
authors.forename: Marie-Victoire
authors.initials: MV
authors.lastname: Albahary
authors.affiliation: IAB, INSERM U1209, CNRS UMR 5309, Grenoble Alps University, 38 043, Grenoble Cedex 9, France.|Hematology, Grenoble Alps University Hospital, 38 043, Grenoble Cedex 9, France.
authors.forename: Remy
authors.initials: R
authors.lastname: Gressin
authors.affiliation: Pharmacovigilance, Grenoble Alps University Hospital, 38 043, Grenoble Cedex 9, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Mallaret
authors.affiliation: HP2, INSERM U1042, Grenoble Alps University, 38 043, Grenoble Cedex 9, France.|Thorax and Vessels, EFCR, Grenoble Alps University Hospital, 38 043, Grenoble Cedex 9, France.
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Pepin
authors.affiliation: HP2, INSERM U1042, Grenoble Alps University, 38 043, Grenoble Cedex 9, France.|Thorax and Vessels, EFCR, Grenoble Alps University Hospital, 38 043, Grenoble Cedex 9, France.|UPMC Paris 6, INSERM UMRS 1158, Sorbonne University, 75 005, Paris, France.|St Antoine Hospital, GHUEP, 75 012, Paris, France.
authors.forename: Sandrine H
authors.initials: SH
authors.lastname: Launois
mesh_terms: D006801:Humans; D006918:Hydroxyurea / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D017286:Polysomnography / Q000379:methods; D012890:Sleep / Q000187:drug effects*; D012893:Sleep Wake Disorders / Q000139:chemically induced*
chemical_list: D006918:Hydroxyurea
keywords: excessive daytime sleepiness; hydroxyurea; unexpected adverse drug reaction