title: Mycobacterium tuberculosis Is Selectively Killed by Rifampin and Rifapentine in Hypoxia at Neutral pH.
abstract: The activities of rifampin, rifapentine, bedaquiline, PA-824, clofazimine, nitazoxanide, isoniazid, amikacin, moxifloxacin, niclosamide, thioridazine, and pyrazinamide were tested against nonreplicating (dormant)Mycobacterium tuberculosisH37Rv under conditions of hypoxia at pHs 5.8 and 7.3, mimicking environments of cellular granulomas and caseous granulomas, respectively. At pH 5.8, several drugs killed dormant bacilli, with the best being rifampin and rifapentine. At pH 7.3, only rifampin and rifapentine efficiently killed dormant bacilli, while all other drugs showed little activity.
authors.affiliation: Dipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanità, Rome, Italy.
authors.forename: Angelo
authors.initials: A
authors.lastname: Iacobino
authors.affiliation: Organismo Notificato Unificato, Istituto Superiore di Sanità, Rome, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Piccaro
authors.affiliation: Dipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanità, Rome, Italy.
authors.forename: Federico
authors.initials: F
authors.lastname: Giannoni
authors.affiliation: Dipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanità, Rome, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Mustazzolu
authors.affiliation: Dipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanità, Rome, Italy lanfranco.fattorini@iss.it.
authors.forename: Lanfranco
authors.initials: L
authors.lastname: Fattorini
mesh_terms: D000693:Anaerobiosis; D000995:Antitubercular Agents / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D007539:Isonicotinic Acids / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000254:growth & development; D009593:Nitroimidazoles / Q000494:pharmacology; D010619:Phenazines / Q000494:pharmacology; D011804:Quinolines / Q000494:pharmacology; D012293:Rifampin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D013844:Thiazoles / Q000494:pharmacology
chemical_list: D000995:Antitubercular Agents; D007539:Isonicotinic Acids; D009593:Nitroimidazoles; D010619:Phenazines; D011804:Quinolines; D013844:Thiazoles; D012293:Rifampin; C018421:rifapentine
keywords: Mycobacterium tuberculosis; dormancy; hypoxia; killing; pH; rifampin; rifapentine; tuberculosis