title: Photothermally triggered on-demand insulin release from reduced graphene oxide modified hydrogels.
abstract: On-demand delivery of therapeutics plays an essential role in simplifying and improving patient care. The high loading capacity of reduced graphene oxide (rGO) for drugs has made this matrix of particular interest for its hybridization with therapeutics. In this work, we describe the formulation of rGO impregnated poly(ethylene glycol) dimethacrylate based hydrogels (PEGDMA-rGO) and their efficient loading with insulin. Near-infrared (NIR) light induced heating of the PEGDMA-rGO hydrogels allows for highly efficient insulin release. Most importantly, we validate that the NIR irradiation of the hydrogel has no effect on the biological and metabolic activities of the released insulin. The ease of insulin loading/reloading makes this photothermally triggered release strategy of interest for diabetic patients. Additionally, the rGO-based protein releasing platform fabricated here can be expanded towards 'on demand' release of various other therapeutically relevant biomolecules.
authors.affiliation: Univ. Lille, CNRS, Centrale Lille, ISEN, Univ. Valenciennes, UMR 8520 - IEMN, F-59000 Lille, France.
authors.forename: Florina
authors.initials: F
authors.lastname: Teodorescu
authors.affiliation: Department of Chemistry, Bogazici University, Bebek, 34342, Istanbul, Turkey.
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Oz
authors.affiliation: Univ. Lille, CNRS, Centrale Lille, ISEN, Univ. Valenciennes, UMR 8520 - IEMN, F-59000 Lille, France; University Lille, CNRS, CHU Lille, Institut Pasteur de Lille, European Genomic Institute of Diabetes (EGID) FR 3508, UMR 8199, Genomique Intégrative et Modélisation des Maladies Métaboliques, F-59000 Lille, France.
authors.forename: Gurvan
authors.initials: G
authors.lastname: Quéniat
authors.affiliation: University Lille, CNRS, CHU Lille, Institut Pasteur de Lille, European Genomic Institute of Diabetes (EGID) FR 3508, UMR 8199, Genomique Intégrative et Modélisation des Maladies Métaboliques, F-59000 Lille, France.
authors.forename: Amar
authors.initials: A
authors.lastname: Abderrahmani
authors.affiliation: Univ. Lille, EA 7365 - GRITA-Groupe de Recherche sur les formes Injectables et les Technologies Associées, F-59000 Lille, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Foulon
authors.affiliation: Univ. Lille, EA 7365 - GRITA-Groupe de Recherche sur les formes Injectables et les Technologies Associées, F-59000 Lille, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Lecoeur
authors.affiliation: Department of Chemistry, Bogazici University, Bebek, 34342, Istanbul, Turkey; RS Research, Teknopark Istanbul, Pendik, 34912, Istanbul, Turkey.
authors.forename: Rana
authors.initials: R
authors.lastname: Sanyal
authors.affiliation: Department of Chemistry, Bogazici University, Bebek, 34342, Istanbul, Turkey. Electronic address: amitav.sanyal@boun.edu.tr.
authors.forename: Amitav
authors.initials: A
authors.lastname: Sanyal
authors.affiliation: Univ. Lille, CNRS, Centrale Lille, ISEN, Univ. Valenciennes, UMR 8520 - IEMN, F-59000 Lille, France.
authors.forename: Rabah
authors.initials: R
authors.lastname: Boukherroub
authors.affiliation: Univ. Lille, CNRS, Centrale Lille, ISEN, Univ. Valenciennes, UMR 8520 - IEMN, F-59000 Lille, France. Electronic address: sabine.szunerits@univ-lille1.fr.
authors.forename: Sabine
authors.initials: S
authors.lastname: Szunerits
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D018938:Caco-2 Cells; D003692:Delayed-Action Preparations / Q000737:chemistry*; D006108:Graphite / Q000737:chemistry*; D056945:Hep G2 Cells; D006358:Hot Temperature; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D007328:Insulin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D008027:Light; D008689:Methacrylates / Q000737:chemistry; D010084:Oxidation-Reduction; D011092:Polyethylene Glycols / Q000737:chemistry; D012869:Skin Absorption; D013552:Swine
chemical_list: D003692:Delayed-Action Preparations; D007004:Hypoglycemic Agents; D007328:Insulin; D008689:Methacrylates; C421283:poly(ethylene glycol)-dimethacrylate; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011092:Polyethylene Glycols; D006108:Graphite
keywords: Hydrogel; Insulin; Photothermal; Reduced graphene oxide; Release