title: African Swine Fever Virus Gets Undressed: New Insights on the Entry Pathway.
abstract: African swine fever virus (ASFV) is a large, multienveloped DNA virus composed of a genome-containing core successively wrapped by an inner lipid envelope, an icosahedral protein capsid, and an outer lipid envelope. In keeping with this structural complexity, recent studies have revealed an intricate entry program. This Gem highlights how ASFV uses two alternative pathways, macropinocytosis and clathrin-mediated endocytosis, to enter into the host macrophage and how the endocytosed particles undergo a stepwise, low pH-driven disassembly leading to inner envelope fusion and core delivery in the cytoplasm.
authors.affiliation: Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, Madrid, Spain gandres@cbm.csic.es.
authors.forename: Germán
authors.initials: G
authors.lastname: Andrés
mesh_terms: D000357:African Swine Fever / Q000276:immunology / Q000378:metabolism / Q000821:virology*; D000358:African Swine Fever Virus / Q000502:physiology*; D000818:Animals; D001692:Biological Transport; D004705:Endocytosis; D008264:Macrophages / Q000276:immunology / Q000378:metabolism / Q000821:virology; D008561:Membrane Fusion; D013552:Swine; D053586:Virus Internalization; D057646:Virus Uncoating
keywords: African swine fever virus; virus entry; virus membrane fusion; virus uncoating