title: Intra-articular hyaluronic acid vs platelet-rich plasma in the treatment of hip osteoarthritis.
abstract: To compare the efficacy of ultrasound-guided intra-articular (IA) treatment with platelet-rich plasma (PRP) versus viscosupplementation (hyaluronic acid HA) in hip osteoarthritis. METHODS: A total of 43 patients affected by monolateral severe hip osteoarthritis (OA) were included in the study. Patients were randomized to receive either intra-articular PRP (3 ml) or HA (30 mg/2 ml; 1,000-2,900 kDa), 3 injections in total - 1/week. Clinical assessments for each patient were made at baseline (T0), 4 (T1), and 16 weeks (T2) of follow-up. The primary efficacy outcome was pain reduction as measured by VAS and by WOMAC pain subscale.
  
  
  
  Data analysis revealed that, compared to T0, in the PRP-treated group VAS scores significantly decreased at T1 but not at T2, thereby indicating an early effect on pain which was not maintained at a longer term follow-up. In the HA group a significant decrease of both VAS and WOMAC values was registered only between T0 and T2.
  
  
  
  Intra-articular PRP had an immediate effect on pain that was not maintained at longer term follow-up when, on the contrary, the effects of intra-articular HA were evident.
authors.affiliation: Physical Medicine and Rehabilitation Unit, AziendaPoliclinico Umberto I, Rome, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Di Sante
authors.affiliation: Orthopaedic Clinic Azienda Policlinico Umberto I, Department of Orthopedic Science, Sapienza Università di Roma, Rome, Italy.
authors.forename: Ciro
authors.initials: C
authors.lastname: Villani
authors.affiliation: Physical Medicine and Rehabilitation Unit, AziendaPoliclinico Umberto I, Department of Physical Medicine and Rehabilitation, Sapienza Università di Roma, Rome, Italy.
authors.forename: Valter
authors.initials: V
authors.lastname: Santilli
authors.affiliation: Orthopaedic Clinic Azienda Policlinico Umberto I, Department of Orthopedic Science, Sapienza Università di Roma, Rome, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Valeo
authors.affiliation: Department of Physical Medicine and Rehabilitation, Sapienza Università di Roma, Rome, Italy.
authors.forename: Emmalisa
authors.initials: E
authors.lastname: Bologna
authors.affiliation: Department of Orthopedic Science, Sapienza Università di Roma, Rome, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Imparato
authors.affiliation: Physical Medicine and Rehabilitation Unit, AziendaPoliclinico Umberto I, Rome, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Paoloni
authors.affiliation: Ultrasound Unit, Rheumatology Department, Sapienza Università di Roma, Rome, Italy. annamaria.iagnocco1@gmail.com.
authors.forename: Annamaria
authors.initials: A
authors.lastname: Iagnocco
mesh_terms: D000368:Aged; D018771:Arthralgia / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control*; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D007270:Injections, Intra-Articular / Q000379:methods; D008297:Male; D015207:Osteoarthritis, Hip / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D010147:Pain Measurement / Q000187:drug effects; D053657:Platelet-Rich Plasma; D016896:Treatment Outcome; D018084:Ultrasonography, Interventional / Q000379:methods*; D055675:Viscosupplements / Q000008:administration & dosage
chemical_list: D055675:Viscosupplements; D006820:Hyaluronic Acid