title: A Novel Synthesis of Fused Uracils: Indenopyrimidopyridazines, Pyrimidopyridazines, and Pyrazolopyrimidines for Antimicrobial and Antitumor Evalution.
abstract: A variety of different compounds of fused uracils were prepared simply by the heating of 6-hydrazinyl-1-methyl-, 6-hydrazinyl-1-propyl-, or 6-hydrazinyl-1,3-dipropyluracil under reflux with ninhydrin, isatin, benzylidene malononitrile, benzylylidene ethyl cyanoacetate, benzil, and phenacyl bromide derivatives. The newly synthesized compounds were completely screened for antimicrobial and antitumor activity.
authors.affiliation: Department of Organic Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Nasr City 11651, Cairo, Egypt. s.elkalyoubi@hotmail.com.|Medical Chemistry Department, Faculty of Medicine (Female Section), Jazan University, Jazan 45142, Saudi Arabia. s.elkalyoubi@hotmail.com.
authors.forename: Samar
authors.initials: S
authors.lastname: El-Kalyoubi
authors.affiliation: Chemistry Department, Faculty of Science (Female Section), Jazan University, Jazan 82621, Saudi Arabia. dr.fatmah2000@gmail.com.
authors.forename: Fatimah
authors.initials: F
authors.lastname: Agili
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008826:Microbial Sensitivity Tests; D014498:Uracil / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D014498:Uracil
keywords: 6-chlorouracil; 6-hydrazinyluracils; isatin indenopyrimidopyridazines; ninhydrin; pyrimidopyridazines; pyrrolopyrimidines