title: Clinical and imaging analysis of subclinical hemophilia combined with coxarthrosis: case report and literature review.
abstract: BACKGROUND
  The incidence of subclinical hemophilic arthritis is low, with this case reports and literature review, we hope clinicians could pay more attention to the diagnosis of subclinical hemophilic arthritis and prevent the misdiagnosis and mistreatment.
  
  
  METHODS
  We analyzed the imaging feature, and therapy of a subclinical hemophilia case with hip lesion by reporting its clinical manifestations, imaging features and therapy procedure, and reviewing literatures.
  
  
  RESULTS
  Hemophilia is a sex-linked recessive hereditary hemorrhagic disease, and the pathogenesis of subclinic hemophilia is concealed, which often involves joint lesion. The imaging of joint lesion of hemophilia cases is typical, which facilitates the differential diagnosis with other joint diseases. The current treatment is mainly supplementary or replacement therapy.
  
  
  CONCLUSIONS
  Hemophilic arthritis cases, especially the mild or subclinical cases without family history and with an older age of onset, are not common. The disease should be further understood, and early diagnosis and treatment is crucial to prevent the progressive development of joint diseases.
authors.affiliation: Department of Orthopedics, The Affiliated Hospital of Academy of Military Medical Sciences, PLA 307th Hospital, Beijing, 100071 China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Orthopedics, The Affiliated Hospital of Academy of Military Medical Sciences, PLA 307th Hospital, Beijing, 100071 China.
authors.forename: Jun
authors.initials: J
authors.lastname: Guo
authors.affiliation: Department of Orthopedics, The Affiliated Hospital of Academy of Military Medical Sciences, PLA 307th Hospital, Beijing, 100071 China.
authors.forename: Qiu
authors.initials: Q
authors.lastname: Cui
authors.affiliation: Department of Orthopedics, The Affiliated Hospital of Academy of Military Medical Sciences, PLA 307th Hospital, Beijing, 100071 China.
authors.forename: Dingfeng
authors.initials: D
authors.lastname: Li
authors.affiliation: Beijing University of Technology, 100 Pingleyuan, Chaoyang District, Beijing, 100022 China.
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Zeng
keywords: Arthritis; Coxarthrosis; Subclinical hemophilia