title: Azoospermia and Testicular Hypoplasia in a Boar Carrier of a Novel Y-Autosome Translocation.
abstract: Few sex-autosome chromosome abnormalities have been documented in domestic animal species. In humans, Y-autosome chromosome abnormalities may occur at a rate of 1/2,000 live births, whereas in the domestic pig only 2 Y-autosome reciprocal translocations have been previously described. During a routine cytogenetic screening of young boars, we identified a new Y-autosome translocation carrier, which after puberty showed semen devoid of sperm and testicular hypoplasia with spermatogenesis arrest. Whole chromosome painting by FISH analysis corroborated the reciprocal nature of the chromosomal exchanges between the Y chromosome and SSC13. The possible causes for the observed meiotic arrest of the carrier are reviewed.
authors.affiliation: Department of Biomedical Sciences, University of Guelph, Guelph, ON, Canada.
authors.forename: Daniel A F
authors.initials: DA
authors.lastname: Villagómez
authors.forename: Tamas
authors.initials: T
authors.lastname: Revay
authors.forename: Brendan
authors.initials: B
authors.lastname: Donaldson
authors.forename: Samira
authors.initials: S
authors.lastname: Rezaei
authors.forename: Alain
authors.initials: A
authors.lastname: Pinton
authors.forename: Manuel
authors.initials: M
authors.lastname: Palomino
authors.forename: Awang
authors.initials: A
authors.lastname: Junaidi
authors.forename: Ali
authors.initials: A
authors.lastname: Honaramooz
authors.forename: W Allan
authors.initials: WA
authors.lastname: King
mesh_terms: D000818:Animals; D053713:Azoospermia / Q000151:congenital* / Q000235:genetics*; D008297:Male; D013091:Spermatogenesis / Q000235:genetics / Q000502:physiology; D013552:Swine; D014178:Translocation, Genetic / Q000235:genetics*; D014998:Y Chromosome / Q000235:genetics / Q000378:metabolism