title: Peroxygenases en route to becoming dream catalysts. What are the opportunities and challenges?
abstract: Peroxygenases are promising catalysts for preparative oxyfunctionalization chemistry as they combine the versatility of P450 monooxygenases with simplicity of cofactor-independent enzymes. Though many interesting applications have been reported, today 'we have only scratched the surface' and significant efforts are necessary to solve issues related to selectivity of the wild type enzymes and low product titers. For this, further elucidation of the vast natural diversity as well as protein and reaction engineering approaches are discussed.
authors.affiliation: School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China.
authors.forename: Yonghua
authors.initials: Y
authors.lastname: Wang
authors.affiliation: School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China.
authors.forename: Dongming
authors.initials: D
authors.lastname: Lan
authors.affiliation: School of Bioscience and Bioengineering, South China University of Technology, Guangzhou 510006, China.
authors.forename: Rabia
authors.initials: R
authors.lastname: Durrani
authors.affiliation: Department of Biotechnology, Delft University of Technology, Van der Maasweg 9, 2629HZ Delft, The Netherlands. Electronic address: F.Hollmann@tudelft.nl.
authors.forename: Frank
authors.initials: F
authors.lastname: Hollmann
mesh_terms: D055162:Biocatalysis; D014644:Genetic Variation; D006900:Hydroxylation; D006899:Mixed Function Oxygenases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D015202:Protein Engineering
chemical_list: D006899:Mixed Function Oxygenases; C022333:peroxygenase