title: Hypertranscription in Development, Stem Cells, and Regeneration.
abstract: Cells can globally upregulate their transcriptome during specific transitions, a phenomenon called hypertranscription. Evidence for hypertranscription dates back over 70 years but has gone largely ignored in the genomics era until recently. We discuss data supporting the notion that hypertranscription is a unifying theme in embryonic development, stem cell biology, regeneration, and cell competition. We review the history, methods for analysis, underlying mechanisms, and biological significance of hypertranscription.
authors.affiliation: Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Center for Reproductive Sciences, University of California, San Francisco, San Francisco, CA 94143, USA.
authors.forename: Michelle
authors.initials: M
authors.lastname: Percharde
authors.affiliation: Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Center for Reproductive Sciences, University of California, San Francisco, San Francisco, CA 94143, USA.
authors.forename: Aydan
authors.initials: A
authors.lastname: Bulut-Karslioglu
authors.affiliation: Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Center for Reproductive Sciences, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: mrsantos@ucsf.edu.
authors.forename: Miguel
authors.initials: M
authors.lastname: Ramalho-Santos
mesh_terms: D000818:Animals; D047108:Embryonic Development / Q000235:genetics*; D006801:Humans; D008213:Lymphocyte Activation / Q000235:genetics; D012038:Regeneration / Q000235:genetics*; D013234:Stem Cells / Q000378:metabolism*; D014158:Transcription, Genetic; D015053:Zygote / Q000378:metabolism
keywords: Chd1; Myc; cell competition; cell number normalization; development; hypertranscription; open chromatin; proliferation; regeneration; self-renewal; stem cells