title: Bioinformatics Tools for Extracellular Vesicles Research.
abstract: Extracellular vesicles (EVs) are a class of membranous vesicles that are released by multiple cell types into the extracellular environment. This unique class of extracellular organelles which play pivotal role in intercellular communication are conserved across prokaryotes and eukaryotes. Depending upon the cell origin and the functional state, the molecular cargo including proteins, lipids, and RNA within the EVs are modulated. Owing to this, EVs are considered as a subrepertoire of the host cell and are rich reservoirs of disease biomarkers. In addition, the availability of EVs in multiple bodily fluids including blood has created significant interest in biomarker and signaling research. With the advancement in high-throughput techniques, multiple EV studies have embarked on profiling the molecular cargo. To benefit the scientific community, existing free Web-based resources including ExoCarta, EVpedia, and Vesiclepedia catalog multiple datasets. These resources aid in elucidating molecular mechanism and pathophysiology underlying different disease conditions from which EVs are isolated. Here, the existing bioinformatics tools to perform integrated analysis to identify key functional components in the EV datasets are discussed.
authors.affiliation: Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, LIMS1, Bundoora, Melbourne, VIC, 3086, Australia.
authors.forename: Shivakumar
authors.initials: S
authors.lastname: Keerthikumar
authors.affiliation: Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, LIMS1, Bundoora, Melbourne, VIC, 3086, Australia.
authors.forename: Lahiru
authors.initials: L
authors.lastname: Gangoda
authors.affiliation: Department of Life Sciences, Pohang University of Science and Technology, Pohang, 790-784, Republic of Korea.
authors.forename: Yong Song
authors.initials: YS
authors.lastname: Gho
authors.affiliation: Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, LIMS1, Bundoora, Melbourne, VIC, 3086, Australia. S.Mathivanan@latrobe.edu.au.
authors.forename: Suresh
authors.initials: S
authors.lastname: Mathivanan
mesh_terms: D000818:Animals; D055252:Cell-Derived Microparticles; D019295:Computational Biology / Q000379:methods*; D016208:Databases, Factual; D055354:Exosomes; D000067128:Extracellular Vesicles / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D012106:Research; D012984:Software; D064878:Web Browser
keywords: Bioinformatics; Ectosomes; Exosomes; Extracellular vesicles; Microvesicles