title: Simulation of multi-probe radiofrequency ablation guided by optical surgery navigation system under different active modes.
abstract: Radiofrequency ablation (RFA) is a crucial alternative treatment for liver cancer with the advantages of minimal invasion and a fast prognosis. However, two problems limit its further application: the orientation of the puncture point and the ablation of large tumors. The optical surgery navigation system in the RFA presents a promising approach for solving the localization problem in the puncturing process, which greatly increases puncture accuracy and has overcome the disadvantages of traditional RFA surgery. In addition, the use of multiple electrodes in the RFA (multi-probe RFA) is proposed and is applied clinically to deal with large tumors. In this study, we present a multi-probe RFA model using the finite element method (FEM) combined with a self-developed optical surgical navigation system. A real 3D liver model was adopted as an effective reference. Based on this model, two-probe RFA simulations were performed under different active modes. An analysis was conducted from the perspective of the temperature and electric potential fields and cell necrosis. The simulation results showed that different active modes had separate advantages and were suitable for different situations. Understanding their advantages can not only help doctors make surgical plans that fit the patients' conditions, but also the understanding can offer a virtual surgery platform for further development in the preoperative planning of RFA incorporated with the surgery navigation system.
authors.affiliation: a Department of Biomedical Engineering , South China University of Technology , Guangzhou , China.
authors.forename: Leyi
authors.initials: L
authors.lastname: Xu
authors.affiliation: b School of Information Science and Technology, Zhongkai University of Agriculture and Engineering , Guangzhou , China.
authors.forename: Ken
authors.initials: K
authors.lastname: Cai
authors.affiliation: a Department of Biomedical Engineering , South China University of Technology , Guangzhou , China.
authors.forename: Rongqian
authors.initials: R
authors.lastname: Yang
authors.affiliation: a Department of Biomedical Engineering , South China University of Technology , Guangzhou , China.
authors.forename: Qinyong
authors.initials: Q
authors.lastname: Lin
authors.affiliation: c School of Information Engineering , Wuyi University , Jiangmen , China.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Yue
authors.affiliation: d School of Information Technology and Electrical Engineering , the University of Queensland , Brisbane , QLD , Australia.
authors.forename: Feng
authors.initials: F
authors.lastname: Liu
mesh_terms: D017115:Catheter Ablation / Q000295:instrumentation*; D003198:Computer Simulation; D006801:Humans; D021621:Imaging, Three-Dimensional; D008113:Liver Neoplasms / Q000601:surgery*; D055096:Optical Devices; D011677:Punctures; D011846:Radio Waves; D025321:Surgery, Computer-Assisted / Q000379:methods*; D014057:Tomography, X-Ray Computed; D014584:User-Computer Interface
keywords: Active mode; RFA; multi-probe; surgery navigation