title: Graphene nanoflakes on transparent glass electrode sensor for electrochemical sensing of anti-diabetic drug.
abstract: Metformin (Mf) plays a major role in controlling insulin level of individuals at risk of developing diabetes mellitus. Overdose of Mf can cause lactic acidosis, diarrhoea, cough, or hoarseness, etc. These particulars point out the identification for selective and sensitive methods of Mf determination. In the present work, graphene nanoflakes-polymethylene blue (GNF-PMB) nano-composites were developed onto fluorine-doped tin oxide (SnO2/F) coated glass substrates for electrochemical sensing of Mf using cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The developed sensor shows quick response time (10 s), linearity as 10-103µM, LOD (0.1 nM), and good shelf life (10 weeks). Attempts have been made to utilize this electrode for estimation of Mf in urine samples. Configured as a highly responsive, reproducible Mf sensor, it combines the electrical properties of GNF and stable electron transfer of PMB. The newly developed Mf sensor presents a promising candidate in point-of-care diagnosis.
authors.affiliation: Amity Institute of Nanotechnology (AINT), AMITY University, Noida, 201313, Uttar Pradesh, India. jags_biotech@yahoo.co.in.
authors.forename: Jagriti
authors.initials: J
authors.lastname: Narang
authors.affiliation: Amity Institute of Physiotherapy, AMITY University, Noida, 201313, Uttar Pradesh, India.
authors.forename: Nitesh
authors.initials: N
authors.lastname: Malhotra
authors.affiliation: Amity Institute of Nanotechnology (AINT), AMITY University, Noida, 201313, Uttar Pradesh, India.
authors.forename: Chaitali
authors.initials: C
authors.lastname: Singhal
authors.affiliation: Amity Institute of Nanotechnology (AINT), AMITY University, Noida, 201313, Uttar Pradesh, India.
authors.forename: Rishabh
authors.initials: R
authors.lastname: Bhatia
authors.affiliation: Amity Institute of Nanotechnology (AINT), AMITY University, Noida, 201313, Uttar Pradesh, India.
authors.forename: Vikas
authors.initials: V
authors.lastname: Kathuria
authors.affiliation: Amity Institute of Nanotechnology (AINT), AMITY University, Noida, 201313, Uttar Pradesh, India.
authors.forename: Manan
authors.initials: M
authors.lastname: Jain
mesh_terms: D058266:Dielectric Spectroscopy / Q000379:methods*; D004566:Electrodes; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D007004:Hypoglycemic Agents / Q000032:analysis*; D008687:Metformin / Q000032:analysis*; D053758:Nanoparticles / Q000737:chemistry*; D017971:Tin Compounds
chemical_list: D007004:Hypoglycemic Agents; D017971:Tin Compounds; D006108:Graphite; D008687:Metformin; C045358:stannic oxide
keywords: Fluorine-doped tin oxide glass electrode; Graphene nanoflakes; Metformin; Polymethylene blue; Sensor; SnO2/F