title: Regulation of Pseudomonas aeruginosa Virulence by Distinct Iron Sources.
abstract: Pseudomonas aeruginosais a ubiquitous environmental bacterium and versatile opportunistic pathogen. Like most other organisms,P. aeruginosarequires iron for survival, yet iron rapidly reacts with oxygen and water to form stable ferric (FeIII) oxides and hydroxides, limiting its availability to living organisms. During infection, iron is also sequestered by the host innate immune system, further limiting its availability.P. aeruginosa'scapacity to cause disease in diverse host environments is due to its ability to scavenge iron from a variety of host iron sources. Work over the past two decades has further shown that different iron sources can affect the expression of distinct virulence traits. This review discusses how the individual components ofP. aeruginosa'siron regulatory network allow this opportunist to adapt to a multitude of host environments during infection.
authors.affiliation: Wound Infections Department, Bacterial Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA. alexandria.a.reinhart.ctr@mail.mil.
authors.forename: Alexandria A
authors.initials: AA
authors.lastname: Reinhart
authors.affiliation: Department of Pharmaceutical Sciences, School of Pharmacy, and Department of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, MD 21201, USA. aoglesby@rx.umaryland.edu.
authors.forename: Amanda G
authors.initials: AG
authors.lastname: Oglesby-Sherrouse
keywords: Pseudomonas aeruginosa; biofilms; heme; iron; siderophores; small RNAs