title: Anticyclic citrullinated peptide antibody in rheumatoid arthritis:a cross-sectional study in Iran.
abstract: OBJECTIVE
  Studies have shown that anticyclic citrullinated peptide antibody (anti-CCP) titers can be useful in the diagnosis of rheumatoid arthritis (RA). We evaluate the association between anti-CCP antibody titers and the demographic, clinical, and laboratory characteristics of RA patients. Moreover, we explore whether there is any relation between joint destruction and demographic and clinical characteristics of RA patients.
  
  
  METHODS
  One hundred and four RA patients with positive anti-CCP titers were compared to 104 RA patients with negative anti-CCP titers. The activity of RA was evaluated using the Disease Activity Score 28 (DAS28). Joint destruction was assessed in the subjects by X-rays of the wrists. Blood samples were collected for assessment of anti-CCP, rheumatoid factor (RF), and erythrocyte sedimentation rate.
  
  
  RESULTS
  Forty-eight (23.0%) males and 160 (76.9%) females were included in this study. RF, DAS28, and joint destruction were significantly different between patients with and without anti-CCP (P < 0.0001). DAS28, duration of disease, hospitalizations, and occupation differed significantly between patients with and without joint destruction (P < 0.0001).
  
  
  CONCLUSIONS
  This study indicates that anti-CCP is correlated with a high disease activity index and more joint destruction in RA patients and it may be used as a prognostic factor for RA.
authors.affiliation: Rheumatology Research Center, Razi Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
authors.forename: Irandokht
authors.initials: I
authors.lastname: Shenavar Masooleh
authors.affiliation: Violet ZAKER ESTEGHAMATI, Banafsheh GHAVIDEL PARSA, Amir HASSANKHANIRheumatology Research Center, Razi Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
authors.forename: Asghar
authors.initials: A
authors.lastname: Hajiabbasi
authors.affiliation: Rheumatology Research Center, Razi Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
authors.forename: Habib
authors.initials: H
authors.lastname: Zayeni
authors.affiliation: Rheumatology Research Center, Razi Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
authors.forename: Atefeh
authors.initials: A
authors.lastname: Ghanbari
authors.affiliation: Rheumatology Research Center, Razi Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
authors.forename: Violet
authors.initials: V
authors.lastname: Zaker Esteghamati
authors.affiliation: Rheumatology Research Center, Razi Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
authors.forename: Banafsheh
authors.initials: B
authors.lastname: Ghavidel Parsa
authors.affiliation: Rheumatology Research Center, Razi Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
authors.forename: Amir
authors.initials: A
authors.lastname: Hassankhani
mesh_terms: D001172:Arthritis, Rheumatoid; D015415:Biomarkers; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007492:Iran; D008297:Male; D010456:Peptides, Cyclic; D012217:Rheumatoid Factor
chemical_list: D015415:Biomarkers; D010456:Peptides, Cyclic; D012217:Rheumatoid Factor
keywords:  rheumatoid arthritis; Anti-CCP; disease activity; joints