title: Dysregulation of Corticostriatal Connectivity in Huntington's Disease: A Role for Dopamine Modulation.
abstract: Aberrant communication between striatum, the main information processing unit of the basal ganglia, and cerebral cortex plays a critical role in the emergence of Huntington's disease (HD), a fatal monogenetic condition that typically strikes in the prime of life. Although both striatum and cortex undergo substantial cell loss over the course of HD, corticostriatal circuits become dysfunctional long before neurons die. Understanding the dysfunction is key to developing effective strategies for treating a progressively worsening triad of motor, cognitive, and psychiatric symptoms. Cortical output neurons drive striatal activity through the release of glutamate, an excitatory amino acid. Striatal outputs, in turn, release γ-amino butyric acid (GABA) and exert inhibitory control over downstream basal ganglia targets. Ample evidence from transgenic rodent models points to dysregulation of corticostriatal glutamate transmission along with corresponding changes in striatal GABA release as underlying factors in the HD behavioral phenotype. Another contributor is dysregulation of dopamine (DA), a modulator of both glutamate and GABA transmission. In fact, pharmacological manipulation of DA is the only currently available treatment for HD symptoms. Here, we review data from animal models and human patients to evaluate the role of DA in HD, including DA interactions with glutamate and GABA within the context of dysfunctional corticostriatal circuitry.
authors.forename: Claudia
authors.initials: C
authors.lastname: Rangel-Barajas
authors.forename: George V
authors.initials: GV
authors.lastname: Rebec
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism*; D003342:Corpus Striatum / Q000378:metabolism*; D006801:Humans; D006816:Huntington Disease / Q000378:metabolism*; D009434:Neural Pathways / Q000378:metabolism
keywords: GABA; Huntington’s disease; basal ganglia; cerebral cortex; corticostriatal pathway; dopamine; glutamate; striatum