title: Primary sclerosing cholangitis: a new cause of distal renal tubular acidosis.
abstract: We describe the first case of distal renal tubular acidosis (dRTA) associated with primary sclerosing cholangitis. A 26-year-old Lao-Thai male patient presented with severe jaundice, metabolic acidosis and hypokalaemia. He was diagnosed of dRTA. Liver transplantation resulted in correction of electrolyte disturbances and hyperbilirubinaemia. A fludrocortisone-furosemide test revealed normal urinary acidification, demonstrating no residual dRTA. This observation suggests that dRTA may be an early manifestation of bilirubin-associated nephropathy or the consequence of an immune mechanism.
authors.affiliation: Department of Nephrology, Dialysis and Transplantation, Hôpital Lapeyronie, University of Montpellier Medical School, Montpellier, France.
authors.forename: Valentin
authors.initials: V
authors.lastname: Goutaudier
authors.affiliation: Department of Nephrology, Dialysis and Transplantation, Hôpital Lapeyronie, University of Montpellier Medical School, Montpellier, France.
authors.forename: Ilan
authors.initials: I
authors.lastname: Szwarc
authors.affiliation: Department of Nephrology, Dialysis and Transplantation, Hôpital Lapeyronie, University of Montpellier Medical School, Montpellier, France.
authors.forename: Jean-Emmanuel
authors.initials: JE
authors.lastname: Serre
authors.affiliation: Department of Hepato-Gastro-Enterology and Liver Transplantation, Hôpital Saint Eloi, University of Montpellier Medical School, Montpellier, France.
authors.forename: Georges-Philippe
authors.initials: GP
authors.lastname: Pageaux
authors.affiliation: SAS RD - Nephrology, Montpellier, France; Department of Nephrology and Dialysis Saint-Guilhem, Sète, France.
authors.forename: Àngel
authors.initials: À
authors.lastname: Argilés
authors.affiliation: Department of Hypertension and Internal Medicine, Hôpital Lapeyronie, University of Montpellier Medical School, Montpellier, France.
authors.forename: Jean
authors.initials: J
authors.lastname: Ribstein
keywords: distal renal tubular acidosis; liver transplantation; primary sclerosing cholangitis