title: HabibTM 4X-assisted resection versus clamp-crush resection for hepatocellular carcinoma: a propensity-matching study.
abstract: Long term outcome of ablation-assisted hepatic resection is unclear for hepatocellular carcinoma (HCC) patients. This study was scheduled to compare the outcome of Habib 4X ablation assisted resection (Habib group) with clamp-crush resection (CC group) for HCC. In this study, we retrospectively enrolled 81 patients from the Habib group and 103 patients from the CC group. Oncologic outcomes were analyzed using a propensity score matching (PSM) method. Compared with the CC group, the Habib group had higher levels of γ-glutamyltransferase (P=0.044) and albumin (P=0.001), larger tumor sizes (P=0.007), shorter operation times (P=0.001), less blood loss (P=0.005), and less blood transfusions (P=0.038). There were no significant differences in complications (P=0.310), recurrence-free survival rates (RFS, P=0.112), or overall survival rates (OS, P=0.203) between the two groups. For the 67 patient pairs selected from the PSM analysis, the Habib group had better RFS and OS (P=0.033 and P=0.014, respectively). A Cox proportional hazards analysis revealed that Habib-assisted resection was an independent factor for RFS and OS (P=0.008 and P=0.016, respectively). Furthermore, for the 42 patients with central and large tumors, the Habib group had better RFS and OS than the CC group (P=0.035 and P=0.038, respectively). However, the differences of RFS and OS (P=0.117 and P=0.126, respectively) were not significant among 92 patients with peripheral or small tumors. Hence, HabibTM 4X-assisted resection is safe and provides better survival for HCC patients, particularly those with central and large tumors.
authors.affiliation: Department of Abdominal Oncosurgery, Cancer Center of Guangzhou Medical University, Guangzhou, China.
authors.forename: Jiliang
authors.initials: J
authors.lastname: Qiu
authors.affiliation: Department of Abdominal Oncosurgery, Cancer Center of Guangzhou Medical University, Guangzhou, China.
authors.forename: Weiqun
authors.initials: W
authors.lastname: Lu
authors.affiliation: Department of Abdominal Oncosurgery, Cancer Center of Guangzhou Medical University, Guangzhou, China.
authors.forename: Nanrong
authors.initials: N
authors.lastname: Yu
authors.affiliation: Department of Abdominal Oncosurgery, Cancer Center of Guangzhou Medical University, Guangzhou, China.
authors.forename: Guohua
authors.initials: G
authors.lastname: Yang
authors.affiliation: Department of Surgery, the Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Abdominal Oncosurgery, Cancer Center of Guangzhou Medical University, Guangzhou, China.
authors.forename: Zhiliang
authors.initials: Z
authors.lastname: Huang
authors.affiliation: Department of Abdominal Oncosurgery, Cancer Center of Guangzhou Medical University, Guangzhou, China.
authors.forename: Jianchang
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Abdominal Oncosurgery, Cancer Center of Guangzhou Medical University, Guangzhou, China.
authors.forename: Kefei
authors.initials: K
authors.lastname: Li
authors.affiliation: Department of Abdominal Oncosurgery, Cancer Center of Guangzhou Medical University, Guangzhou, China.
authors.forename: Houwei
authors.initials: H
authors.lastname: Xu
authors.affiliation: Department of Abdominal Oncosurgery, Cancer Center of Guangzhou Medical University, Guangzhou, China.
authors.forename: Shicai
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Abdominal Oncosurgery, Cancer Center of Guangzhou Medical University, Guangzhou, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Zeng
authors.affiliation: Department of Abdominal Oncosurgery, Cancer Center of Guangzhou Medical University, Guangzhou, China.
authors.forename: Haiying
authors.initials: H
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000601:surgery*; D017115:Catheter Ablation / Q000379:methods*; D005260:Female; D006498:Hepatectomy / Q000379:methods*; D006801:Humans; D008113:Liver Neoplasms / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D057216:Propensity Score; D012189:Retrospective Studies; D016019:Survival Analysis; D015996:Survival Rate; D016896:Treatment Outcome
keywords: HabibTM 4X; clamp-crush; complication; hepatic resection; hepatocellular carcinoma