title: Profiling of the Predicted Circular RNAs in Ductal In Situ and Invasive Breast Cancer: A Pilot Study.
abstract: The recent advantage obtained by next generation sequencing allows a depth investigation of a new "old" kind of noncoding transcript, the circular RNAs. Circular RNAs are nontranslated RNAs, typically nonpolyadenylated, with a resistance to exonucleases that gives them the ability to be more stable than the common linear RNA isoforms. We used a bioinformatic detection tool (CIRCexplorer) to research predictive circRNAs from the next generation sequenced data of five samples of ductal in situ carcinoma (DCIS) and matched adjacent invasive ductal carcinoma (IDC). Furthermore, we also investigated the circular RNAs expressed in MCF7, an invasive breast ductal carcinoma cell line. We described the genomic context of the predicted circular RNAs and we address the hypothetical possible functional roles. This study showed a perspective of a panel of predictive circRNAs identified and the function that circRNAs could exert.
authors.affiliation: LTTA, Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Via Fossato di Mortara 70, 44123 Ferrara, Italy.
authors.forename: Marco
authors.identifier: 0000-0003-2655-4792
authors.initials: M
authors.lastname: Galasso
authors.affiliation: LTTA, Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Via Fossato di Mortara 70, 44123 Ferrara, Italy.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Costantino
authors.affiliation: Department of Medicine, Center for Molecular Medicine (CMM) L8:02, Karolinska Institutet, 17176 Stockholm, Sweden.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Pasquali
authors.affiliation: LTTA, Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Via Fossato di Mortara 70, 44123 Ferrara, Italy.
authors.forename: Linda
authors.initials: L
authors.lastname: Minotti
authors.affiliation: LTTA, Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Via Fossato di Mortara 70, 44123 Ferrara, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Baldassari
authors.affiliation: LTTA, Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Via Fossato di Mortara 70, 44123 Ferrara, Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Corrà
authors.affiliation: LTTA, Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Via Fossato di Mortara 70, 44123 Ferrara, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Agnoletto
authors.affiliation: LTTA, Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Via Fossato di Mortara 70, 44123 Ferrara, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Volinia