title: Targeting the Cholinergic System to Develop a Novel Therapy for Huntington's Disease.
abstract: In this review, we outline the role of the cholinergic system in Huntington's disease, and briefly describe the dysfunction of cholinergic transmission, cholinergic neurons, cholinergic receptors and cholinergic survival factors observed in post-mortem human brains and animal models of Huntington's disease. We postulate how the dysfunctional cholinergic system can be targeted to develop novel therapies for Huntington's disease, and discuss the beneficial effects of cholinergic therapies in pre-clinical and clinical studies.
authors.forename: Gary X
authors.initials: GX
authors.lastname: D'Souza
authors.forename: Henry J
authors.initials: HJ
authors.lastname: Waldvogel
mesh_terms: D000818:Animals; D018678:Cholinergic Agents / Q000627:therapeutic use*; D059329:Cholinergic Neurons / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D006816:Huntington Disease / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D018678:Cholinergic Agents
keywords: Huntington’s disease; acetylcholine; choline acetyltransferase; cholinergic; cholinergic drugs; cholinergic receptors