title: A Review on Phytochemistry and Pharmacology of Cortex Periplocae.
abstract: Cortex Periplocae, as a traditional Chinese herbal medicine, has been widely used for autoimmune diseases, especially rheumatoid arthritis. Due to its potential pharmaceutical values, more studies about the biological activities ofCortex Periplocaehave been conducted recently. Meanwhile, the adverse reaction ofCortex Periplocaeis not a negligible problem in clinic. In this article, we reviewed a series of articles and summarized the recent studies ofCortex Periplocaein the areas of phytochemistry and pharmacology. More than 100 constituents have been isolated and identified fromCortex Periplocae, including steroids, cardiac glycosides, terpenoids, and fatty acid compounds. The crude extracts ofCortex Periplocaeand its active compounds exhibit various biological activities, such as cardiotonic effect, anticancer action, and anti-inflammatory effect. This paper aims to provide an overall review on the bioactive ingredients, pharmacological effect, and toxicity of this plant. Furthermore, this review suggests investigating and developing new clinical usages according to the above pharmacological effects.
authors.affiliation: Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. llyangtcm@163.com.|Tianjin Key Laboratory of Phytochemistry and Pharmaceutical Analysis, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. llyangtcm@163.com.
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.affiliation: Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. zishan826@126.com.
authors.forename: Jin
authors.initials: J
authors.lastname: Li
authors.affiliation: Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. z.k.ken@263.net.
authors.forename: Kun
authors.initials: K
authors.lastname: Zhou
authors.affiliation: Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. hejun673@163.com.|Tianjin Key Laboratory of Phytochemistry and Pharmaceutical Analysis, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. hejun673@163.com.
authors.forename: Jun
authors.initials: J
authors.lastname: He
authors.affiliation: College of Material Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036, China. caojun91@163.com.
authors.forename: Jun
authors.initials: J
authors.lastname: Cao
authors.affiliation: Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA. mingruia@umich.edu.
authors.forename: Mingrui
authors.initials: M
authors.lastname: An
authors.affiliation: Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. Tcmcyx@126.com.|Tianjin Key Laboratory of Phytochemistry and Pharmaceutical Analysis, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. Tcmcyx@126.com.
authors.forename: Yan-Xu
authors.initials: YX
authors.lastname: Chang
mesh_terms: D000970:Antineoplastic Agents / Q000032:analysis / Q000494:pharmacology; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D002316:Cardiotonic Agents / Q000032:analysis / Q000494:pharmacology; D002681:China; D029001:Herbal Medicine / Q000379:methods*; D008516:Medicine, Chinese Traditional / Q000379:methods*; D064209:Phytochemicals / Q000032:analysis / Q000494:pharmacology*; D008517:Phytotherapy / Q000379:methods; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D002316:Cardiotonic Agents; D064209:Phytochemicals; D010936:Plant Extracts
keywords: Cortex Periplocae; biological activities; periplocin; phytochemistry; traditional Chinese medicines