title: Measuring the actual I-131 thyroid uptake curve with a collar detector system: a feasibility study.
abstract: Radionuclide therapy using I-131 is commonly used for the treatment of benign thyroid diseases. The therapeutic dose to be administered is calculated based on the type of disease, the volume of the thyroid, and the measured uptake percentage. This methodology assumes a similar biological half-life of iodine, whereas in reality a large variation in biological half-life is observed. More knowledge about the actual biological half-life of iodine for individual patients will improve the quantification of the delivered radiation dose during radioiodine therapy and could aid the evaluation of the success of the therapy. In this feasibility study we used a novel measurement device [Collar Therapy Indicator (CoTI)] to measure the uptake curve of patients undergoing I-131 radioiodine therapy. The CoTI device is a light-weight wearable device that contains two independent gamma radiation detectors that are placed in a collar. By comparing results of thyroid uptake measurements with results obtained with a gamma camera, the precision of the system is demonstrated. Additionally, for three patients the uptake curve is measured during 48 h of admission in the hospital. The presented results demonstrate the feasibility of the new measurement device to measure the uptake curve during radioiodine therapy.
authors.affiliation: Department of Medical Physics, St. Antonius Hospital, Nieuwegein, The Netherlands. p.brinks@antoniusziekenhuis.nl.
authors.forename: Peter
authors.identifier: 0000-0001-6653-3297
authors.initials: P
authors.lastname: Brinks
authors.affiliation: Department of Medical Physics, St. Antonius Hospital, Nieuwegein, The Netherlands.
authors.forename: Koen
authors.initials: K
authors.lastname: Van Gils
authors.affiliation: Department of Nuclear Medicine, St. Antonius Hospital, Nieuwegein, The Netherlands.
authors.forename: Ellen
authors.initials: E
authors.lastname: Kranenborg
authors.affiliation: Department of Nuclear Medicine, St. Antonius Hospital, Nieuwegein, The Netherlands.
authors.forename: Jules
authors.initials: J
authors.lastname: Lavalaye
authors.affiliation: Department of Medical Physics, St. Antonius Hospital, Nieuwegein, The Netherlands.
authors.forename: Dennis
authors.initials: D
authors.lastname: Dieckens
authors.affiliation: Department of Medical Physics, St. Antonius Hospital, Nieuwegein, The Netherlands.
authors.forename: Jan B A
authors.initials: JBA
authors.lastname: Habraken
mesh_terms: D001692:Biological Transport; D005240:Feasibility Studies; D006801:Humans; D007457:Iodine Radioisotopes / Q000378:metabolism* / Q000627:therapeutic use; D016014:Linear Models; D011874:Radiometry / Q000295:instrumentation*; D015203:Reproducibility of Results; D013961:Thyroid Gland / Q000378:metabolism* / Q000528:radiation effects
chemical_list: D007457:Iodine Radioisotopes
keywords: Dosimetry; I-131; Iodine; Pharmacokinetics; Radionuclide therapy; Thyroid