title: [Clinical features of mild encephalitis/encephalopathy with a reversible splenial lesion in children].
abstract: OBJECTIVE
  To investigate the clinical features of mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) in children.
  
  
  METHODS
  The clinical data of 8 children with MERS were retrospectively analyzed.
  
  
  RESULTS
  The mean age of onset was 5 years and 2 months (range 10 months to 12 years). The major clinical features included a history of prodromal infection, and among these children, 5 had pyrexia and 4 had vomiting. Of all the children, 6 were manifested as convulsion and 3 each were manifested as disturbance of consciousness and paroxysmal paropsia. Cranial diffusion-weighted magnetic resonance imaging (MRI) showed high signals in the splenium of the corpus callosum. Among these children, one child had symmetric and multiple long T1 and long T2 signals in the bilateral centrum semiovale and part of the temporal white matter. MRI reexamination performed after 5-30 days showed the disappearance of abnormal signals in all the children. The children were followed up for 3 months to 2 years, and no child experienced abnormal neurodevelopment.
  
  
  CONCLUSIONS
  The development of MERS in children is closely associated with infection. MERS is characterized by high signals in the splenium of the corpus callosum on cranial diffusion-weighted MRI. Most children have good prognosis.
authors.affiliation: Department of Pediatrics, Maternity and Children's Hospital, Tangshan, Hebei 063000, China. liuyin2002@126.com.
authors.forename: Yin
authors.initials: Y
authors.lastname: Liu
authors.forename: Guang-Min
authors.initials: GM
authors.lastname: Li
authors.forename: Shu-Hua
authors.initials: SH
authors.lastname: Li
authors.forename: Xiao-Qing
authors.initials: XQ
authors.lastname: Wang
authors.forename: Su-Rong
authors.initials: SR
authors.lastname: Li
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Hong-Fang
authors.initials: HF
authors.lastname: Wang
authors.forename: Bao-Dong
authors.initials: BD
authors.lastname: Pang
authors.forename: Jia-Hua
authors.initials: JH
authors.lastname: Wu
mesh_terms: D001927:Brain Diseases / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D003337:Corpus Callosum / Q000473:pathology*; D004660:Encephalitis / Q000473:pathology*; D005260:Female; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D012189:Retrospective Studies