title: Successful treatment of refractory listeria meningitis and bacteremia with trimethoprim-sulfamethoxazole in an immunocompetent child.
abstract: Listeria monocytogenes is an important cause of life-threatening bacteremia and meningoencephalitis in neonates, pregnant women, the elderly, and immunocompromised individuals. However, it is an uncommon cause of illness in immunocompetent children beyond the neonatal period. Ampicillin with or without an aminoglycoside remains the best treatment for listeriosis. Here, we report a rare case of Listeria meningitis and bacteremia in a 7-month-old immunocompetent girl, which was refractory to ampicillin plus gentamicin treatment and successfully treated by the addition of TMP/SMX.
authors.affiliation: Divisions of Pediatric Infectious Diseases, Gazi University Faculty of Medicine, Ankara, Turkey.
authors.forename: Meltem
authors.initials: M
authors.lastname: Polat
authors.affiliation: Divisions of Pediatric Infectious Diseases, Gazi University Faculty of Medicine, Ankara, Turkey.
authors.forename: Soner Sertan
authors.initials: SS
authors.lastname: Kara
authors.affiliation: Divisions of Pediatric Infectious Diseases, Gazi University Faculty of Medicine, Ankara, Turkey.
authors.forename: Anıl
authors.initials: A
authors.lastname: Tapısız
authors.affiliation: Divisions of Pediatric Emergency, Gazi University Faculty of Medicine, Ankara, Turkey.
authors.forename: Okşan
authors.initials: O
authors.lastname: Derinöz
authors.affiliation: Department of Microbiology, Gazi University Faculty of Medicine, Ankara, Turkey.
authors.forename: Kayhan
authors.initials: K
authors.lastname: Çağlar
authors.affiliation: Divisions of Pediatric Infectious Diseases, Gazi University Faculty of Medicine, Ankara, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Tezer
mesh_terms: D000667:Ampicillin / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D016470:Bacteremia / Q000150:complications / Q000188:drug therapy*; D005260:Female; D005839:Gentamicins / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D008089:Listeria monocytogenes / Q000187:drug effects*; D008584:Meningitis, Listeria / Q000150:complications / Q000188:drug therapy*; D016896:Treatment Outcome; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; D000667:Ampicillin; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
keywords: Listeria meningitis; immunocompetent child; trimethoprim-sulfamethoxazole