title: Metabolic abnormalities in patients with inflammatory rheumatic diseases.
abstract: Patients with rheumatoid arthritis (RA) experience an increased cardiometabolic risk factor burden that is substantially driven by systemic inflammation. This occurs less consistently in patients with ankylosing spondylitis (AS). Psoriatic arthritis most strongly associates with excess adiposity and metabolic risk. RA patients also often have systemic inflammation-induced proinflammatory high-density lipoprotein (HDL) cholesterol particles and lean/muscle mass loss in association with increased adiposity, a condition termed rheumatoid cachexia, which further enhances cardiovascular risk. The presence of proinflammatory HDL and lean mass loss was also reported in patients with AS. Individualized aerobic and resistance exercise programs can improve body composition and metabolic risk factor profiles in RA and AS. Future studies should assess how long-term lifestyle changes can be effectuated and if these can influence cardiovascular events in inflammatory rheumatic diseases. Herein, we review the current evidence on metabolic abnormalities in inflammatory arthritis. We propose management strategies and a research agenda.
authors.affiliation: Rheumatology Division, Universitair Ziekenhuis en Vrije Universiteit Brussel, Belgium; Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. Electronic address: patrick.dessein22@gmail.com.
authors.forename: Patrick H
authors.initials: PH
authors.lastname: Dessein
authors.affiliation: Rheumatology Division, Charlotte Maxeke Johannesburg Academic Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Solomon
authors.affiliation: Lillehammer Hospital for Rheumatic Diseases, Norway Hospital for Rheumatic Diseases, Department of Rheumatology, Lillehammer, and Innlandet Hospital Trust, Department of Research, Brumunddal, Norway; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
authors.forename: Ivana
authors.initials: I
authors.lastname: Hollan
mesh_terms: D002318:Cardiovascular Diseases / Q000209:etiology*; D006801:Humans; D007249:Inflammation / Q000209:etiology; D012216:Rheumatic Diseases / Q000150:complications*; D012307:Risk Factors
keywords: Ankylosing spondylitis; Metabolic abnormalities; Psoriatic arthritis; Rheumatoid arthritis