title: The Microscope as a Tool for Disease Discovery-A Personal Voyage.
abstract: This review reflects the trajectory of my career in hematopathology, and my personal reflections on scientific advances in the field. During the course of more than 40 years, the approach to classification of hematological malignancies has evolved from descriptive approaches, based on either cytological or clinical features, to a modern approach, which incorporates cutting-edge technologies. My philosophy has focused on defining individual diseases, an approach that can best lead to an understanding of molecular pathogenesis. To quote Carolus Linnaeus ( 1 , p. 19), the father of taxonomy, "The first step in wisdom is to know the things themselves; this notion consists in having a true idea of the objects; objects are distinguished and known by classifying them methodically and giving them appropriate names. Therefore, classification and name-giving will be the foundation of our science."
authors.affiliation: Hematopathology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892; email: elainejaffe@nih.gov.
authors.forename: Elaine S
authors.initials: ES
authors.lastname: Jaffe
mesh_terms: D019337:Hematologic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D006801:Humans; D008853:Microscopy / Q000379:methods*
keywords: B cells; T cells; autobiography; cell of origin; malignant lymphoma; molecular diagnosis; molecular oncology