title: The Link Between Angiogenesis and Endothelial Metabolism.
abstract: Angiogenesis has traditionally been viewed from the perspective of how endothelial cells (ECs) coordinate migration and proliferation in response to growth factor activation to form new vessel branches. However, ECs must also coordinate their metabolism and adapt metabolic fluxes to the rising energy and biomass demands of branching vessels. Recent studies have highlighted the importance of such metabolic regulation in the endothelium and uncovered core metabolic pathways and mechanisms of regulation that drive the angiogenic process. In this review, we discuss our current understanding of EC metabolism, how it intersects with angiogenic signal transduction, and how alterations in metabolic pathways affect vessel morphogenesis. Understanding EC metabolism promises to reveal new perspectives on disease mechanisms in the vascular system with therapeutic implications for disorders with aberrant vessel growth and function.
authors.affiliation: Angiogenesis and Metabolism Laboratory, Max Planck Institute for Heart and Lung Research, D-61231 Bad Nauheim, Germany; email: michael.potente@mpi-bn.mpg.de.|International Institute of Molecular and Cell Biology, 02-109 Warsaw, Poland.|German Center for Cardiovascular Research (DZHK), Partner Site Rhein-Main, D-13347 Berlin, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Potente
authors.affiliation: Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, Katholieke Universiteit Leuven, 3000 Leuven, Belgium.|Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Center, VIB, 3000 Leuven, Belgium.
authors.forename: Peter
authors.initials: P
authors.lastname: Carmeliet
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000502:physiology; D042783:Endothelial Cells / Q000473:pathology*; D004730:Endothelium, Vascular / Q000473:pathology*; D006801:Humans; D009024:Morphogenesis / Q000502:physiology; D009389:Neovascularization, Pathologic / Q000473:pathology*; D015398:Signal Transduction / Q000502:physiology
keywords: VEGF; angiogenesis; endothelial metabolism; fatty acid oxidation; glycolysis; mitochondria