title: Mitochondrial adaptations in aged skeletal muscle: effect of exercise training.
abstract: The aging process is associated with a decline in mitochondrial functions. Mitochondria dysfunction is involved in initiation and progression of many health problems including neuromuscular, metabolic and cardiovascular diseases. It is well known that endurance exercise improves mitochondrial function, especially in the elderly. However, recent studies have demonstrated that resistance training lead also to substantial increases in mitochondrial function in skeletal muscle. A comprehensive understanding of the cellular mechanisms involved in the skeletal muscle mitochondrial adaptations to exercise training in healthy elderly subjects, can help practitioners to design and prescribe more effective exercise trainings.
authors.affiliation: Faculty of Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran. mosaferi@um.ac.ir.
authors.forename: M M
authors.initials: MM
authors.lastname: Ziaaldini
authors.forename: S Ra
authors.initials: SR
authors.lastname: Hosseini
authors.forename: M
authors.initials: M
authors.lastname: Fathi
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D000375:Aging / Q000378:metabolism*; D015444:Exercise / Q000502:physiology*; D006801:Humans; D008931:Mitochondria, Muscle / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000378:metabolism*; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / Q000378:metabolism; D010807:Physical Endurance / Q000502:physiology
chemical_list: C486497:PPARGC1A protein, human; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha