title: Genetic Analysis ofBDNF,GNB3,MTHFR,ACEandAPOEVariants in Major and Recurrent Depressive Disorders in Russia.
abstract: This study was conducted to explore the possibility of association between the single-nucleotide polymorphisms rs6264 ofBDNF, rs5443 ofGNB3, and rs1801133 ofMTHFR; theIn/Delpolymorphism ofACE; and theε2allele ofAPOEand major depressive disorder (MDD) and recurrent depressive disorder (RDD) in an East Slavic population. Generalized multifactor dimensionality reduction (GMDR) method was applied to detect gene-gene interactions. One hundred fifty patients with RDD (101 females and 49 males) and 208 patients with MDD (115 females and 93 males) were included in the study. The comparison group consisted of 200 unrelated individuals. There was no significant difference in genotype distributions or allele frequencies between the controls and any of the diagnostic groups. Nevertheless, the frequency of theGallele of rs1801133 ofMTHFRwas higher in the RDD group and the frequency of theCallele of rs6264 ofBDNFwas higher in the MDD group. The difference between the controls and specific disease groups almost reached statistical significance (P= 0.08). A GMDR did not reveal optimal two- and three-dimensional models with significant prediction accuracies (P˃ 0.05) for the MDD or RDD groups.
authors.affiliation: Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russian Federation.
authors.forename: E A
authors.initials: EA
authors.lastname: Bondarenko
authors.affiliation: Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russian Federation.
authors.forename: M I
authors.initials: MI
authors.lastname: Shadrina
authors.affiliation: Moscow Research and Clinical Center for Neuropsychiatry of the Healthcare Department, Moscow, Russian Federation.
authors.forename: M N
authors.initials: MN
authors.lastname: Grishkina
authors.affiliation: Moscow Research and Clinical Center for Neuropsychiatry of the Healthcare Department, Moscow, Russian Federation.
authors.forename: T A
authors.initials: TA
authors.lastname: Druzhkova
authors.affiliation: Moscow Research and Clinical Center for Neuropsychiatry of the Healthcare Department, Moscow, Russian Federation.
authors.forename: R G
authors.initials: RG
authors.lastname: Akzhigitov
authors.affiliation: Moscow Research and Clinical Center for Neuropsychiatry of the Healthcare Department, Moscow, Russian Federation.; Institute of Higher Nervous Activity and Neurophysiology Russian Academy of Sciences Russia, Russian Federation.
authors.forename: N V
authors.initials: NV
authors.lastname: Gulyaeva
authors.affiliation: Moscow Research and Clinical Center for Neuropsychiatry of the Healthcare Department, Moscow, Russian Federation.
authors.forename: A B
authors.initials: AB
authors.lastname: Guekht
authors.affiliation: Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russian Federation.
authors.forename: P A
authors.initials: PA
authors.lastname: Slominsky
mesh_terms: D000328:Adult; D001057:Apolipoproteins E / Q000235:genetics*; D044466:Asian People; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D003865:Major Depressive Disorder / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006239:Haplotypes / Q000235:genetics; D020962:Heterotrimeric GTP-Binding Proteins / Q000235:genetics*; D006801:Humans; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics; D012307:Risk Factors; D012426:Russia / Q000453:epidemiology
chemical_list: D001057:Apolipoproteins E; D019208:Brain-Derived Neurotrophic Factor; C000595803:GNB3 protein, human; C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2); C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A; D020962:Heterotrimeric GTP-Binding Proteins
keywords: ACE and APOE; BDNF; GNB3; MTHFR