title: Synchronized Chiral Induction between [5]Helicene-Spermine Ligand and B-Z DNA Transition.
abstract: The 2,13-dimethoxy[5]helicene-spermine ligand 8 b possesses an axial chirality. The racemic 8 b was bound to B-DNA by the accompanying induction of its (P)-chirality together with the B-to-Z helicity change of the duplex DNA, [(dC-dG)3]2. The (P)-chirality of the bound 8 b, in turn, transitioned to the (M)-chirality according to the Z-helicity of the DNA. These results illustrate the chirality synchronization between the DNA and the ligand.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
authors.forename: Kensuke
authors.initials: K
authors.lastname: Kawara
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
authors.forename: Genichiro
authors.initials: G
authors.lastname: Tsuji
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
authors.forename: Yosuke
authors.identifier: http://orcid.org/0000-0002-8985-3629
authors.initials: Y
authors.lastname: Taniguchi
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
authors.forename: Shigeki
authors.identifier: http://orcid.org/0000-0003-2013-2441
authors.initials: S
authors.lastname: Sasaki
mesh_terms: D002942:Circular Dichroism; D059371:DNA, B-Form / Q000737:chemistry* / Q000378:metabolism; D043542:DNA, Z-Form / Q000737:chemistry* / Q000378:metabolism; D008024:Ligands; D008968:Molecular Conformation; D009690:Nucleic Acid Conformation; D011083:Polycyclic Compounds / Q000737:chemistry* / Q000378:metabolism; D013096:Spermine / Q000737:chemistry* / Q000378:metabolism; D013237:Stereoisomerism; D013816:Thermodynamics
chemical_list: D059371:DNA, B-Form; D043542:DNA, Z-Form; D008024:Ligands; D011083:Polycyclic Compounds; C031660:helicenes; D013096:Spermine
keywords: B-Z transition; DNA; [5]helicene; chirality; synchronization