title: Gestational Hyperandrogenism in Developmental Programming.
abstract: Androgen excess (hyperandrogenism) is a common endocrine disorder affecting women of reproductive age. The potential causes of androgen excess in women include polycystic ovary syndrome, congenital adrenal hyperplasia (CAH), adrenal tumors, and racial disparity among many others. During pregnancy, luteoma, placental aromatase deficiency, and fetal CAH are additional causes of gestational hyperandrogenism. The present report reviews the various phenotypes of hyperandrogenism during pregnancy and its origin, pathophysiology, and the effect of hyperandrogenism on the fetal developmental trajectory and offspring consequences.
authors.affiliation: College of Human Medicine, Michigan State University, East Lansing, Michigan.
authors.forename: Christopher
authors.initials: C
authors.lastname: Hakim
authors.affiliation: Department of Pediatrics, University of Michigan, Ann Arbor, Michigan.
authors.forename: Vasantha
authors.initials: V
authors.lastname: Padmanabhan
authors.affiliation: College of Human Medicine, Michigan State University, East Lansing, Michigan.|Department of Pediatrics, Texas Tech University Health Sciences Center, Permian Basin Campus, Odessa, Texas.
authors.forename: Arpita K
authors.initials: AK
authors.lastname: Vyas
mesh_terms: D000728:Androgens / Q000502:physiology; D000818:Animals; D005260:Female; D047109:Fetal Development; D006801:Humans; D017588:Hyperandrogenism / Q000209:etiology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000209:etiology*
chemical_list: D000728:Androgens