title: Association Between Statin Medications and COPD-Specific Outcomes: A Real-World Observational Study.
abstract: BACKGROUND
  Disease-modifying drugs are not yet available for the management of chronic obstructive pulmonary disease (COPD). HMG-CoA reductase inhibitors (statins) have anti-inflammatory properties and are therefore being considered for use in the management of COPD.
  
  
  OBJECTIVE
  Our objective was to examine the association between statin use and COPD-specific outcomes in a real-world setting.
  
  
  METHODS
  This was a retrospective longitudinal dynamic cohort study that used Medicaid claims data from multiple years (2005-2008) to identify patients with newly diagnosed COPD. Statin therapy was determined from the prescription drug file using National Drug Codes (NDCs). COPD-specific outcomes such as hospitalizations and emergency room and outpatient visits were identified based on a primary diagnosis of COPD. Multivariable logistic regressions with inverse probability treatment weights (IPTWs) were used to examine the relationship between statin therapy and COPD-specific outcomes.
  
  
  RESULTS
  The study included 19,060 Medicaid beneficiaries with newly diagnosed COPD, 30.3% of whom received statins during the baseline period. Adults who received statins had significantly lower rates of COPD-specific hospitalizations (4.7 vs. 5.2%; p < 0.05), emergency room visits (13.4 vs. 15.4%; p < 0.001), and outpatient visits (41.4 vs. 44.7%; p < 0.001) than those who did not receive statin therapy. Even after adjusting for observed selection bias with IPTWs, adults receiving statins were less likely to have COPD-specific hospitalizations [adjusted odds ratio (AOR) 0.76; 95% confidence interval (CI) 0.66-0.87], emergency room visits (AOR 0.81; 95% CI 0.75-0.89), and outpatient visits (AOR 0.86; 95% CI 0.80-0.91) than those not receiving statins.
  
  
  CONCLUSIONS
  Findings from this study suggest statins have beneficial effects in patients with newly diagnosed COPD and warrant further clinical trial investigation.
authors.affiliation: RTI Health Solutions, 300 Park Offices Drive, Research Triangle Park, Durham, NC, USA. majmera@rti.org.
authors.forename: Mayank
authors.initials: M
authors.lastname: Ajmera
authors.affiliation: Department of Biostatistics and Health Services Research, MD Anderson Cancer Center, University of Texas, Houston, TX, USA.
authors.forename: Chan
authors.initials: C
authors.lastname: Shen
authors.affiliation: Department of Pharmaceutical Systems and Policy, School of Pharmacy, West Virginia University, Morgantown, WV, USA.
authors.forename: Usha
authors.initials: U
authors.lastname: Sambamoorthi