title: Fetuin-A, serum amyloid A and tumor necrosis factor alpha levels in periodontal health and disease.
abstract: OBJECTIVE
  This study is evaluating fetuin-A, serum amyloid A (SAA) and tumor necrosis factor alpha (TNF-α) levels in gingival crevicular fluid (GCF) and serum samples in periodontal health and disease.
  
  
  METHODS
  Sixty patients were divided into three groups: Group 1 periodontal health (n = 20), Group 2 gingivitis (n = 20) and Group 3 chronic periodontitis (CP) (n = 20). GCF and serum samples were evaluated using enzyme-linked immunosorbent assay kit.
  
  
  RESULTS
  SAA and TNF-α levels in GCF and serum were significantly higher in patients with gingivitis and CP compared with controls (P < 0.016). Contrarily, fetuin-A levels in GCF and serum were significantly higher in controls than in patients with gingivitis and CP (P < 0.016). In CP group, a significant correlation was observed between GCF-SAA amount and the number of sites with 4 ≤ PPD ≤ 5 mm (P < 0.05). There was a significant correlation between GCF-fetuin-A levels and the number of sites with PPD ≥ 6 mm (P < 0.05). GCF-TNF-α was found to have a significant relationship with the number of sites with 4 ≤ PPD ≤ 5 mm and PPD ≥ 6 mm (P < 0.05).
  
  
  CONCLUSIONS
  In conclusion, serum and total levels of SAA significantly increased, whereas fetuin-A levels significantly decreased, with increasing severity of PD.
authors.affiliation: Department of Periodontology, Faculty of Dentistry, Bulent Ecevit University, Zonguldak, Turkey.
authors.forename: Ç C
authors.identifier: http://orcid.org/0000-0003-3856-4218
authors.initials: ÇC
authors.lastname: Türer
authors.affiliation: Department of Periodontology, Faculty of Dentistry, Bulent Ecevit University, Zonguldak, Turkey.
authors.forename: U
authors.initials: U
authors.lastname: Ballı
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Bulent Ecevit University, Zonguldak, Turkey.
authors.forename: B
authors.initials: B
authors.lastname: Güven
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002908:Chronic Disease; D005260:Female; D005883:Gingival Crevicular Fluid / Q000378:metabolism*; D005891:Gingivitis / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000378:metabolism*; D000685:Serum Amyloid A Protein / Q000378:metabolism*; D012720:Severity of Illness Index; D014409:Tumor Necrosis Factor-alpha / Q000097:blood / Q000378:metabolism*; D060749:alpha-2-HS-Glycoprotein / Q000378:metabolism*
chemical_list: D000685:Serum Amyloid A Protein; D014409:Tumor Necrosis Factor-alpha; D060749:alpha-2-HS-Glycoprotein
keywords: Fetuin-A; gingival crevicular fluid; periodontal disease; serum; serum amyloid A