title: Analysis of complete genomes of the rubella virus genotypes 1E and 2B which circulated in China, 2000-2013.
abstract: Rubella viruses of genotypes 1E and 2B are currently the most frequently detected wild-type viruses in the world. Genotype 1E viruses from China have been genetically distinct from genotype 1E viruses found elsewhere, while genotype 2B viruses found in China are not distinguishable from genotype 2B viruses from other areas. Genetic clusters of viruses of both genotypes were defined previously using sequences of the 739-nt genotyping window. Here we report phylogenic analysis using whole genomic sequences from seven genotype 1E and three genotype 2B viruses which were isolated in China between 2000 and 2013 and confirm the subgrouping of current circulating genotypes 1E and 2B viruses. In addition, the whole genomic characterization of Chinese rubella viruses was clarified. The results indicated that the Chinese rubella viruses were highly conserved at the genomic level, and no predicted amino acid variations were found at positions where functional domains of the proteins were identified. Therefore, it gives us the idea that the rubella control and elimination goal should be achieved if vaccine immunization coverage continues maintaining at the high level.
authors.affiliation: WHO WPRO Regional Reference Measles/Rubella Laboratory and Key Laboratory of Medical Virology Ministry of Health, National Institute for Viral Disease Control and Prevention, Beijing, People's Republic of China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zhu
authors.affiliation: Measles, Mumps, Rubella, and Herpesviruses Laboratory Branch, National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
authors.forename: Min-Hsin
authors.initials: MH
authors.lastname: Chen
authors.affiliation: Measles, Mumps, Rubella, and Herpesviruses Laboratory Branch, National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
authors.forename: Emily
authors.initials: E
authors.lastname: Abernathy
authors.affiliation: Measles, Mumps, Rubella, and Herpesviruses Laboratory Branch, National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
authors.forename: Joseph
authors.initials: J
authors.lastname: Icenogle
authors.affiliation: Anhui Center for Disease Control and Prevention, Hefei, People's Republic of China.
authors.forename: Shujie
authors.initials: S
authors.lastname: Zhou
authors.affiliation: Shandong Center for Disease Control and Prevention, Jinan, People's Republic of China.
authors.forename: Changyin
authors.initials: C
authors.lastname: Wang
authors.affiliation: Chongqing Center for Disease Control and Prevention, Chongqing, People's Republic of China.
authors.forename: Chunfang
authors.initials: C
authors.lastname: Zhao
authors.affiliation: Liaoning Center for Disease Control and Prevention, Changchun, People's Republic of China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Hainan Center for Disease Control and Prevention, Haikou, People's Republic of China.
authors.forename: Haiyun
authors.initials: H
authors.lastname: Chen
authors.affiliation: Shaanxi Center for Disease Control and Prevention, Xi'an, People's Republic of China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Si
authors.affiliation: WHO WPRO Regional Reference Measles/Rubella Laboratory and Key Laboratory of Medical Virology Ministry of Health, National Institute for Viral Disease Control and Prevention, Beijing, People's Republic of China.
authors.forename: Wenbo
authors.initials: W
authors.lastname: Xu
mesh_terms: D002681:China / Q000453:epidemiology; D005260:Female; D016679:Genome, Viral; D005838:Genotype; D060005:Genotyping Techniques; D006801:Humans; D008297:Male; D012409:Rubella / Q000453:epidemiology / Q000235:genetics*; D012412:Rubella virus / Q000235:genetics*