title: Increased fetal lung T2 signal is not due to increasing surfactant concentration: an in vitro T2 mapping analysis.
abstract: The aim of this study was to perform in vitro T2 mapping of serial dilutions of pharmaceutical surfactant.
  
  
  
  Magnetic resonance imaging. Magnetic resonance scanning was performed on serial dilutions of surfactant on large bore clinical magnets at a field strength of 1.5 T Philips and 3.0 T (Achieva TX, Philips Healthcare, the Netherlands).
  
  
  
  The curves demonstrate a small increasing trend between surfactant concentration and R2 (shortened T2's), with a 7.3% increase in R2 for each doubling of surfactant concentration (95% confidence interval: 6.1-8.6%, p < 0.001).
  
  
  
  The increasing lung/liver T2 signal ratio seen in fetal lungs with increasing gestational age is not due to increasing surfactant concentration. © 2016 John Wiley & Sons, Ltd.
authors.affiliation: Department of Radiology, University of Washington, Seattle, WA, USA.
authors.forename: Theodore J
authors.initials: TJ
authors.lastname: Dubinsky
authors.affiliation: Department of Radiology, University of Washington, Seattle, WA, USA.
authors.forename: Mariam
authors.initials: M
authors.lastname: Moshiri
authors.affiliation: Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA.
authors.forename: Kristina
authors.initials: K
authors.lastname: Adams Waldorf
authors.affiliation: Department of Radiology, University of Washington, Seattle, WA, USA.
authors.forename: Greg
authors.initials: G
authors.lastname: Wilson
authors.affiliation: Department of Radiology, University of Washington, Seattle, WA, USA.
authors.forename: Jeffrey H
authors.initials: JH
authors.lastname: Maki
authors.affiliation: Department of Radiology, University of Washington, Seattle, WA, USA.
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Hippe
mesh_terms: D005260:Female; D005325:Fetal Organ Maturity; D005333:Fetus / Q000378:metabolism; D005865:Gestational Age; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging* / Q000378:metabolism*; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods*; D013501:Surface-Active Agents / Q000032:analysis / Q000378:metabolism*
chemical_list: D013501:Surface-Active Agents