title: HSV1 Pulls the Deamidation tRIGger.
abstract: Viruses have evolved a remarkable array of strategies to escape the host's innate immune responses. In this issue of Cell Host & Microbe, Zhao et al. (2016b) reveal a viral strategy to inactivate RIG-I signaling that relies on deamidation of RIG-I.
authors.affiliation: Department of Microbiology and Molecular Medicine, University of Geneva, 1211 Geneva 4, Switzerland. Electronic address: dominique.garcin@unige.ch.
authors.forename: Dominique
authors.initials: D
authors.lastname: Garcin
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000071457:DEAD Box Protein 58 / Q000276:immunology*; D006561:Herpes Simplex / Q000276:immunology; D018259:Herpesvirus 1, Human / Q000276:immunology*; D007113:Immunity, Innate; D050838:Interferon Regulatory Factor-3 / Q000378:metabolism; D050839:Interferon Regulatory Factor-7 / Q000378:metabolism; D016328:NF-kappa B / Q000378:metabolism; D025821:Polyubiquitin / Q000494:pharmacology; D011971:Receptors, Immunologic; D015398:Signal Transduction / Q000276:immunology*; D048029:TNF Receptor-Associated Factor 6 / Q000378:metabolism; D015678:Viral Structural Proteins / Q000276:immunology
chemical_list: C494232:IRF3 protein, human; C494234:IRF7 protein, human; D050838:Interferon Regulatory Factor-3; D050839:Interferon Regulatory Factor-7; D016328:NF-kappa B; D011971:Receptors, Immunologic; D048029:TNF Receptor-Associated Factor 6; C084763:UL37 protein, Human herpesvirus 1; D015678:Viral Structural Proteins; D025821:Polyubiquitin; D000255:Adenosine Triphosphate; C452820:RIGI protein, human; D000071457:DEAD Box Protein 58