title: Lymphocyte Antigen 75Polymorphisms Are Associated with Disease Susceptibility and Phenotype in Japanese Patients with Inflammatory Bowel Disease.
abstract: Recent genome-wide association studies have rapidly improved our understanding of the molecular pathways leading to inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC). Although several reports have demonstrated that gene single nucleotide polymorphisms (SNPs) are associated with susceptibility to IBD, its precise genetic factors have not been fully clarified. Here, we performed an association analysis betweenlymphocyte antigen 75(LY75) genetic variations and IBD susceptibility or phenotype. SNPs were genotyped in 51 CD patients, 94 UC patients, and 269 healthy controls of Japanese ethnicity. We detected a significant relationship with CD susceptibility for the rs16822581LY75SNP (P= 0.045). One haplotype (GT,P= 0.042) was also associated with CD susceptibility, while another carrying the opposite SNP (CA) was linked to an absence of surgical history for CD. Our findings confirm thatLY75is involved in CD susceptibility and may play a role in disease activity in the Japanese population.
authors.affiliation: Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Atsuhiro
authors.initials: A
authors.lastname: Hirayama
authors.affiliation: Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Satoru
authors.identifier: 0000-0002-6364-9654
authors.initials: S
authors.lastname: Joshita
authors.affiliation: Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Kei
authors.initials: K
authors.lastname: Kitahara
authors.affiliation: Department of Gastroenterology, Japanese Red Cross Society Suwa Hospital, Suwa, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Mukawa
authors.affiliation: Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Suga
authors.affiliation: Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Takeji
authors.initials: T
authors.lastname: Umemura
authors.affiliation: Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Eiji
authors.initials: E
authors.lastname: Tanaka
authors.affiliation: Department of Legal Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Masao
authors.identifier: 0000-0002-6400-5658
authors.initials: M
authors.lastname: Ota
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000235:genetics*; D015415:Biomarkers / Q000032:analysis*; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000453:epidemiology / Q000235:genetics*; D007564:Japan / Q000453:epidemiology; D037181:Lectins, C-Type / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D015778:Minor Histocompatibility Antigens / Q000235:genetics*; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D011956:Receptors, Cell Surface / Q000235:genetics*
chemical_list: D015703:Antigens, CD; D015415:Biomarkers; C093569:DEC-205 receptor; D037181:Lectins, C-Type; D015778:Minor Histocompatibility Antigens; D011956:Receptors, Cell Surface