title: Proton Pump Inhibitor Use Is Associated With Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae Rectal Carriage at Hospital Admission: A Cross-Sectional Study.
abstract: In this cross-sectional study, 8.5% of patients using proton pump inhibitors (PPIs) were rectal carriers of extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E), compared with 2.9% of non-PPI users. In multivariable analysis, PPI use was independently associated with ESBL-E rectal carriage at hospital admission (adjusted odds ratio, 3.89; 95% confidence interval, 1.65 - 9.19).
authors.affiliation: Laboratory for Microbiology and Infection Control, Amphia Hospital, Breda.|Laboratory for Medical Microbiology and Immunology, Elisabeth-TweeSteden Hospital, Tilburg.
authors.forename: Pepijn
authors.initials: P
authors.lastname: Huizinga
authors.affiliation: Amphia Academy Infectious Disease Foundation, Amphia Hospital, Breda.|Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht; and.
authors.forename: Marjolein Kluytmans-
authors.initials: MK
authors.lastname: van den Bergh
authors.affiliation: Laboratory for Microbiology and Infection Control, Amphia Hospital, Breda.
authors.forename: Miranda
authors.initials: M
authors.lastname: van Rijen
authors.affiliation: Laboratory for Microbiology and Infection Control, Amphia Hospital, Breda.
authors.forename: Ina
authors.initials: I
authors.lastname: Willemsen
authors.affiliation: Department of Clinical Pharmacy, Amphia Hospital, Breda, The Netherlands.
authors.forename: Nils
authors.initials: N
authors.lastname: van 't Veer
authors.affiliation: Laboratory for Microbiology and Infection Control, Amphia Hospital, Breda.|Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht; and.
authors.forename: Jan
authors.initials: J
authors.lastname: Kluytmans
mesh_terms: D000368:Aged; D002353:Carrier State / Q000453:epidemiology* / Q000382:microbiology*; D003430:Cross-Sectional Studies; D004755:Enterobacteriaceae / Q000201:enzymology* / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections / Q000382:microbiology*; D005243:Feces / Q000382:microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D016017:Odds Ratio; D010343:Patient Admission; D015995:Prevalence; D054328:Proton Pump Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D012007:Rectum / Q000382:microbiology*; D012307:Risk Factors; D001618:beta-Lactamases / Q000096:biosynthesis*
chemical_list: D054328:Proton Pump Inhibitors; D001618:beta-Lactamases
keywords: ESBL; carriage; proton pump inhibitor; risk factor.