title: Drug-induced nephropathies.
abstract: Drugs are associated frequently with the development of various types of acute and chronic kidney diseases. Nephrotoxicity is associated most commonly with injury in the tubulointerstitial compartment manifested as either acute tubular injury or acute interstitial nephritis. A growing number of reports has also highlighted the potential for drug-induced glomerular disease, including direct cellular injury and immune-mediated injury. Recognition of drug-induced nephropathies and rapid discontinuation of the offending agents are critical to maximizing the likelihood of renal function recovery. This review will focus on the pathology and pathogenesis of drug-induced acute interstitial nephritis and drug-induced glomerular diseases.
authors.affiliation: Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
authors.forename: Paisit
authors.initials: P
authors.lastname: Paueksakon
authors.affiliation: Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
authors.forename: Agnes B
authors.initials: AB
authors.lastname: Fogo
mesh_terms: D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced*
keywords: drug-induced acute interstitial nephritis; drug-induced glomerular disease; drug-induced nephropathies