title: Oscillatory integration windows in neurons.
abstract: Oscillatory synchrony among neurons occurs in many species and brain areas, and has been proposed to help neural circuits process information. One hypothesis states that oscillatory input creates cyclic integration windows: specific times in each oscillatory cycle when postsynaptic neurons become especially responsive to inputs. With paired local field potential (LFP) and intracellular recordings and controlled stimulus manipulations we directly test this idea in the locust olfactory system. We find that inputs arriving in Kenyon cells (KCs) sum most effectively in a preferred window of the oscillation cycle. With a computational model, we show that the non-uniform structure of noise in the membrane potential helps mediate this process. Further experiments performed in vivo demonstrate that integration windows can form in the absence of inhibition and at a broad range of oscillation frequencies. Our results reveal how a fundamental coincidence-detection mechanism in a neural circuit functions to decode temporally organized spiking.
authors.affiliation: National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA.|Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Kanpur 208016, India.
authors.forename: Nitin
authors.identifier: 0000-0002-8408-3848
authors.initials: N
authors.lastname: Gupta
authors.affiliation: Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Kanpur 208016, India.
authors.forename: Swikriti Saran
authors.initials: SS
authors.lastname: Singh
authors.affiliation: National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA.
authors.forename: Mark
authors.identifier: 0000-0001-9200-1884
authors.initials: M
authors.lastname: Stopfer
mesh_terms: D000818:Animals; D006110:Grasshoppers; D008564:Membrane Potentials / Q000502:physiology*; D008959:Models, Neurological; D008962:Models, Theoretical; D024521:Mushroom Bodies / Q000166:cytology*; D009474:Neurons / Q000502:physiology*; D009622:Noise; D018408:Patch-Clamp Techniques; D012903:Smell / Q000502:physiology*