title: Recent Advances in Stimuli-Responsive Release Function Drug Delivery Systems for Tumor Treatment.
abstract: Benefiting from the development of nanotechnology, drug delivery systems (DDSs) with stimuli-responsive controlled release function show great potential in clinical anti-tumor applications. By using a DDS, the harsh side effects of traditional anti-cancer drug treatments and damage to normal tissues and organs can be avoided to the greatest extent. An ideal DDS must firstly meet bio-safety standards and secondarily the efficiency-related demands of a large drug payload and controlled release function. This review highlights recent research progress on DDSs with stimuli-responsive characteristics. The first section briefly reviews the nanoscale scaffolds of DDSs, including mesoporous nanoparticles, polymers, metal-organic frameworks (MOFs), quantum dots (QDs) and carbon nanotubes (CNTs). The second section presents the main types of stimuli-responsive mechanisms and classifies these into two categories: intrinsic (pH, redox state, biomolecules) and extrinsic (temperature, light irradiation, magnetic field and ultrasound) ones. Clinical applications of DDS, future challenges and perspectives are also mentioned.
authors.affiliation: School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China. salamicky@sina.cn.
authors.forename: Chendi
authors.initials: C
authors.lastname: Ding
authors.affiliation: School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China. njustlingtong321@sina.com.
authors.forename: Ling
authors.initials: L
authors.lastname: Tong
authors.affiliation: School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China. fjnjust@163.com.
authors.forename: Jing
authors.initials: J
authors.lastname: Feng
authors.affiliation: School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China. fujiajun668@gmail.com.
authors.forename: Jiajun
authors.initials: J
authors.lastname: Fu
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008027:Light; D060526:Magnetic Fields; D053758:Nanoparticles / Q000737:chemistry; D036103:Nanotechnology; D037742:Nanotubes, Carbon / Q000737:chemistry; D009369:Neoplasms / Q000188:drug therapy; D010084:Oxidation-Reduction; D011108:Polymers / Q000737:chemistry; D045663:Quantum Dots / Q000737:chemistry; D013696:Temperature; D014465:Ultrasonics
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D037742:Nanotubes, Carbon; D011108:Polymers
keywords: anti-tumor treatment; drug delivery system; nanotechnology; stimuli response