title: Warmed, humidified CO2insufflation benefits intraoperative core temperature during laparoscopic surgery: A meta-analysis.
abstract: BACKGROUND
  Intraoperative hypothermia is linked to postoperative adverse events. The use of warmed, humidified CO2to establish pneumoperitoneum during laparoscopy has been associated with reduced incidence of intraoperative hypothermia. However, the small number and variable quality of published studies have caused uncertainty about the potential benefit of this therapy. This meta-analysis was conducted to specifically evaluate the effects of warmed, humidified CO2during laparoscopy.
  
  
  METHODS
  An electronic database search identified randomized controlled trials performed on adults who underwent laparoscopic abdominal surgery under general anesthesia with either warmed, humidified CO2or cold, dry CO2. The main outcome measure of interest was change in intraoperative core body temperature.
  
  
  RESULTS
  The database search identified 320 studies as potentially relevant, and of these, 13 met the inclusion criteria and were included in the analysis. During laparoscopic surgery, use of warmed, humidified CO2is associated with a significant increase in intraoperative core temperature (mean temperature change, 0.3°C), when compared with cold, dry CO2insufflation.CONCLUSION: Warmed, humidified CO2insufflation during laparoscopic abdominal surgery has been demonstrated to improve intraoperative maintenance of normothermia when compared with cold, dry CO2.
authors.affiliation: Epworth HealthCare, Melbourne, Victoria, Australia.
authors.forename: Meara
authors.initials: M
authors.lastname: Dean
authors.affiliation: Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.|Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia.
authors.forename: Robert
authors.initials: R
authors.lastname: Ramsay
authors.affiliation: Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.|Department of Surgery, St Vincent's Hospital, University of Melbourne, Melbourne, Victoria, Australia.
authors.forename: Alexander
authors.initials: A
authors.lastname: Heriot
authors.affiliation: Epworth HealthCare, Melbourne, Victoria, Australia.
authors.forename: John
authors.initials: J
authors.lastname: Mackay
authors.affiliation: Epworth HealthCare, Melbourne, Victoria, Australia.
authors.forename: Richard
authors.initials: R
authors.lastname: Hiscock
authors.affiliation: Epworth HealthCare, Melbourne, Victoria, Australia.|Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.|Department of Surgery, St Vincent's Hospital, University of Melbourne, Melbourne, Victoria, Australia.
authors.forename: A Craig
authors.initials: AC
authors.lastname: Lynch
mesh_terms: D002245:Carbon Dioxide; D006801:Humans; D006813:Humidity; D006979:Hyperthermia, Induced; D007035:Hypothermia / Q000517:prevention & control*; D007431:Intraoperative Complications / Q000517:prevention & control*; D010535:Laparoscopy; D011028:Pneumoperitoneum, Artificial; D011183:Postoperative Complications / Q000517:prevention & control*
chemical_list: D002245:Carbon Dioxide
keywords: Laparoscopy; meta-analysis; temperature