title: Aberrant default mode network homogeneity in patients with first-episode treatment-naive melancholic depression.
abstract: Melancholic depression is a relatively homogenous subtype of major depressive disorders (MDD). The condition has several endogenous symptoms and represents strong biological components. However, its specific neurobiological mechanisms remain unknown. Previous neuroimaging findings indicated that default mode network (DMN) is closely related to MDD. The present study examined the network homogeneity (NH) of the DMN in patients with melancholic MDD.
  
  
  
  A total of 33 first-episode, treatment-naive melancholic MDD patients and 32 healthy controls underwent a resting-state functional magnetic resonance imaging scan. The data were analyzed using the NH method.
  
  
  
  Compared with healthy controls, patients with melancholic MDD showed low NH values in the right middle temporal gyrus and temporal pole (MTG/TP). The abnormal NH of this region and clinical characteristics were not correlated.
  
  
  
  Abnormal NH pattern of DMN exists in patients with melancholic MDD. This feature may be part of the pathophysiological basis of this disorder.
authors.affiliation: Mental Health Institute of The Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan 410011, China.
authors.forename: Xilong
authors.initials: X
authors.lastname: Cui
authors.affiliation: Mental Health Institute of The Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan 410011, China.
authors.forename: Wenbin
authors.initials: W
authors.lastname: Guo
authors.affiliation: Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
authors.forename: Tian-Xiao
authors.initials: TX
authors.lastname: Yang
authors.affiliation: Institute of Education, Hunan Agricultural University, Changsha, Hunan, China.
authors.forename: Xin-Hua
authors.initials: XH
authors.lastname: Yang
authors.affiliation: Department of Applied Psychology, Hunan University of Chinese Medicine, Changsha, Hunan, China.
authors.forename: Yefei
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Applied Psychology, Hunan University of Chinese Medicine, Changsha, Hunan, China.
authors.forename: Jingbo
authors.initials: J
authors.lastname: Gong
authors.affiliation: Mental Health Institute of The Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan 410011, China.
authors.forename: Changlian
authors.initials: C
authors.lastname: Tan
authors.affiliation: Mental Health Institute of The Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan 410011, China. Electronic address: xiegrpsy@126.com.
authors.forename: Guangrong
authors.initials: G
authors.lastname: Xie
mesh_terms: D000328:Adult; D063132:Connectome; D003865:Major Depressive Disorder / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D013702:Temporal Lobe / Q000503:physiopathology*; D055815:Young Adult
keywords: Default mode network; Melancholic major depressive disorder; Network homogeneity; Resting-state imaging