title: Endoscopic Bariatric and Metabolic Therapies: Surgical Analogues and Mechanisms of Action.
abstract: Obesity is a worsening pandemic with numerous related comorbid illnesses. Conservative management including lifestyle modification and medications have limited efficacy. In contradistinction, bariatric surgery is effective, however, with substantial cost and non-negligible morbidity and mortality. As such, a small percentage of eligible patients undergo surgery. Over the past decade, endoscopic bariatric and metabolic therapies have been introduced as a less invasive option for the treatment of obesity and its related comorbid illnesses. This article reviews major endoscopic bariatric and metabolic therapies, their surgical analogues, and proposed mechanisms of action. Clinical trial data for each device also are discussed.
authors.affiliation: Division of Gastroenterology, Hepatology and Endoscopy, Department of Internal Medicine, Brigham and Women's Hospital, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts.
authors.forename: Pichamol
authors.initials: P
authors.lastname: Jirapinyo
authors.affiliation: Division of Gastroenterology, Hepatology and Endoscopy, Department of Internal Medicine, Brigham and Women's Hospital, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts. Electronic address: ccthompson@bwh.harvard.edu.
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Thompson
mesh_terms: D050110:Bariatric Surgery / Q000379:methods*; D004724:Endoscopy / Q000379:methods*; D006801:Humans; D009765:Obesity / Q000601:surgery*
keywords: Aspire; Bariatric; Diabetes; Duo; EBMT; EBT; ESG; EndoBarrier; Endoscopic Sleeve Gastroplasty; Endoscopy; GLP-1; Gastric Balloon; Ghrelin; IMAS; Incretin; Magnetic; Metabolic; Obalon; Obesity; Orbera; POSE; PYY