title: The potentials and limitations of neuro-biomarkers as predictors of outcome in neonates with birth asphyxia.
abstract: Perinatal asphyxia and its complication, hypoxic-ischemic encephalopathy, are still among the major causes of perinatal mortality and morbidity. Despite accurate standard postnatal monitoring procedures, the post-insult period is crucial because at a time when radiologic pictures are still silent, brain damage may already be at a subclinical stage. Against this background, the measurement of quantitative parameters, such as constituents of nervous tissue, that are able to detect subclinical lesions at a stage when routine brain monitoring procedures are still silent, could be particularly useful. Therefore, in the present review we report the potentials and limitations of biomarkers in predicting outcome in neonates complicated by perinatal asphyxia.
authors.affiliation: Dept. of Cardiology and Laboratory Research, S. Donato Milanese University Hospital, Milan, Italy. Electronic address: angela.satriano@gmail.com.
authors.forename: Angela
authors.initials: A
authors.lastname: Satriano
authors.affiliation: Dept. of Cardiology and Laboratory Research, S. Donato Milanese University Hospital, Milan, Italy. Electronic address: francesca.pluchinotta@gmail.com.
authors.forename: Francesca
authors.initials: F
authors.lastname: Pluchinotta
authors.affiliation: Dept. of Maternal, Fetal and Neonatal Medicine, "C. Arrigo" Children's Hospital Alessandria, Italy. Electronic address: francesca.gazzolo@libero.it.
authors.forename: Francesca
authors.initials: F
authors.lastname: Gazzolo
authors.affiliation: Dept. of Maternal, Fetal and Neonatal Medicine, "C. Arrigo" Children's Hospital Alessandria, Italy. Electronic address: tinal1@hotmail.it.
authors.forename: Laura
authors.initials: L
authors.lastname: Serpero
authors.affiliation: Dept. of Maternal, Fetal and Neonatal Medicine, "C. Arrigo" Children's Hospital Alessandria, Italy. Electronic address: dgazzolo@hotmail.com.
authors.forename: Diego
authors.initials: D
authors.lastname: Gazzolo
mesh_terms: D001238:Asphyxia Neonatorum / Q000097:blood / Q000134:cerebrospinal fluid* / Q000652:urine; D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid / Q000652:urine; D002490:Central Nervous System / Q000378:metabolism*; D006801:Humans; D007231:Infant, Newborn
chemical_list: D015415:Biomarkers
keywords: Brain damage; HIE; Newborn; Perinatal asphyxia; S100B