title: Magnetic Resonance Imaging to Visualize Disintegration of Oral Formulations.
abstract: This article demonstrates that magnetic resonance imaging can visualize the disintegration of a variety of paracetamol containing oral formulations in an in vitro setting and in vivo in the human stomach. The different formulations had unique disintegration profiles which could be imaged both in vitro and in vivo. No special formulation approaches or other contrast agents were required. These data demonstrate the potential for further use of magnetic resonance imaging to investigate and understand the disintegration behavior of different formulation types in vivo, and could potentially be used as a teaching tool in pharmaceutical and medical curricula.
authors.affiliation: The University of Auckland, School of Pharmacy, Auckland 1142, New Zealand. Electronic address: l.curley@auckland.ac.nz.
authors.forename: Louise
authors.initials: L
authors.lastname: Curley
authors.affiliation: The University of Auckland, School of Pharmacy, Auckland 1142, New Zealand.
authors.forename: Jordan
authors.initials: J
authors.lastname: Hinton
authors.affiliation: The University of Auckland, Centre for Advanced MRI, Auckland 1142, New Zealand.
authors.forename: Cameron
authors.initials: C
authors.lastname: Marjoribanks
authors.affiliation: Department of Anatomy with Radiology, The University of Auckland, Auckland 1142, New Zealand.
authors.forename: Ali
authors.initials: A
authors.lastname: Mirjalili
authors.affiliation: The University of Auckland, School of Pharmacy, Auckland 1142, New Zealand.
authors.forename: Julia
authors.initials: J
authors.lastname: Kennedy
authors.affiliation: The University of Auckland, School of Pharmacy, Auckland 1142, New Zealand. Electronic address: d.svirskis@auckland.ac.nz.
authors.forename: Darren
authors.initials: D
authors.lastname: Svirskis
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage* / Q000378:metabolism*; D000284:Administration, Oral; D003692:Delayed-Action Preparations; D004339:Drug Compounding; D041981:Gastrointestinal Tract / Q000000981:diagnostic imaging* / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D012995:Solubility; D013607:Tablets
chemical_list: D003692:Delayed-Action Preparations; D013607:Tablets; D000082:Acetaminophen
keywords: formulation; gastrointestinal; imaging methods; oral drug delivery; tablet