title: Purified Lesser weever fish venom (Trachinus vipera) induces eryptosis, apoptosis and cell cycle arrest.
abstract: Accidents caused by the sting of Trachinus vipera (known as Lesser weever fish) are relatively common in shallow waters of the Mediterranean. Symptoms after the sting vary from severe pain to edema or even tissue necrosis in some cases. Here we show that purified Lesser weever fish venom induces eryptosis, the suicidal erythrocyte death, and apoptosis of human colon carcinoma cells. The venom leads to erythrocyte shrinkage, phosphatidylserine translocation and increased intracellular Ca2+, events typical for eryptosis. According to mitochondrial staining cancer cells dyed after the activation of the intrinsic apoptotic pathway. Trachinus vipera venom further causes cell cycle arrest.
authors.affiliation: Laboratory of Biomonitoring of the Environment (LR01/ES14), Faculty of Sciences of Bizerte, Tunis street, 7021 Zarzouna, Bizerte, Tunisia.|University of Carthage, Amilcar avenue 77, 1054 Tunisia.|Department of Cardiology, Vascular Medicine and Physiology, University of Tuebingen, Gmelinstr. 5/Otfried-Mueller-Str. 10, D-72076 Tuebingen, Germany.
authors.forename: Myriam
authors.initials: M
authors.lastname: Fezai
authors.affiliation: Centre de Recherche de Biochimie Macromoléculaire - CNRS, UMR 5237, Mende 1919, 34293 Montpellier, France.|University of Montpellier, Auguste Broussonet street 163, 34090 Montpellier, France.
authors.forename: Chaker
authors.initials: C
authors.lastname: Slaymi
authors.affiliation: Laboratory of Biomonitoring of the Environment (LR01/ES14), Faculty of Sciences of Bizerte, Tunis street, 7021 Zarzouna, Bizerte, Tunisia.|University of Carthage, Amilcar avenue 77, 1054 Tunisia.
authors.forename: Mossadok
authors.initials: M
authors.lastname: Ben-Attia
authors.affiliation: Department of Cardiology, Vascular Medicine and Physiology, University of Tuebingen, Gmelinstr. 5/Otfried-Mueller-Str. 10, D-72076 Tuebingen, Germany.
authors.forename: Florian
authors.initials: F
authors.lastname: Lang
authors.affiliation: Department of Cardiology, Vascular Medicine and Physiology, University of Tuebingen, Gmelinstr. 5/Otfried-Mueller-Str. 10, D-72076 Tuebingen, Germany.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Jemaà
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001733:Bites and Stings; D002118:Calcium / Q000378:metabolism; D059447:Cell Cycle Checkpoints / Q000187:drug effects*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003110:Colonic Neoplasms / Q000188:drug therapy*; D000072817:Eryptosis / Q000187:drug effects*; D004912:Erythrocytes / Q000473:pathology; D005397:Fish Venoms / Q000494:pharmacology*; D045325:HCT116 Cells; D006801:Humans; D010473:Perciformes / Q000378:metabolism*; D010718:Phosphatidylserines / Q000378:metabolism; D014416:Tunisia
chemical_list: D005397:Fish Venoms; D010718:Phosphatidylserines; D002118:Calcium