title: Hydroxypropylcellulose as matrix carrier for novel cage-like microparticles prepared by spray-freeze-drying technology.
abstract: The objective of this study is to design novel dissolution-enhanced microparticles loaded poorly soluble drug nanocrystals used a low viscosity of hydroxypropylcellulose (HPC) as matrix carrier. An interesting approach combined homogenization and the spray-freeze-drying technique was developed. The results demonstrated that the ratio of HPC to drug played an important role in size-reduction efficiency of drug during homogenization. And the formation of cage-like structure of the composite particles depended on ratio of HPC to drug. The spray-freeze-dried composite particles with HPC ratio of 1:2, 1:1 and 2:1 possessed excellent redispersibility, which attributed to its porous matrix and large surface area (3000m2/g). The dissolution of spray-freeze-dried composite particles with higher ratios of HPC (1:2 and 1:1) was significantly enhanced, which attributed to the particle size reduction of drug. The HPC could immobilize drug nanocrystals in its cage-like structure and prevent it from the subsequent agglomeration during storage. In conclusion, the prepared cage-like microparticles is a promising basis for further formulation development.
authors.affiliation: Jiangxi University of Traditional Chinese Medicine, 818 MEILINGDADAO Road, Nanchang 330004, China.
authors.forename: Shaofeng
authors.initials: S
authors.lastname: Wei
authors.affiliation: Department of Pharmaceutics, 94th Hospital of People's Liberation Army, Nanchang 330000, China.
authors.forename: Yueqin
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Jiangxi University of Traditional Chinese Medicine, 818 MEILINGDADAO Road, Nanchang 330004, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Luo
authors.affiliation: Jiangxi University of Traditional Chinese Medicine, 818 MEILINGDADAO Road, Nanchang 330004, China.
authors.forename: Xiaoru
authors.initials: X
authors.lastname: He
authors.affiliation: Jiangxi University of Traditional Chinese Medicine, 818 MEILINGDADAO Road, Nanchang 330004, China. Electronic address: feigleYue@outlook.com.
authors.forename: Pengfei
authors.initials: P
authors.lastname: Yue
authors.affiliation: Jiangxi University of Traditional Chinese Medicine, 818 MEILINGDADAO Road, Nanchang 330004, China.
authors.forename: Zhiyu
authors.initials: Z
authors.lastname: Guan
authors.affiliation: Jiangxi University of Traditional Chinese Medicine, 818 MEILINGDADAO Road, Nanchang 330004, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Yang
keywords: Cage-like microparticles; Hydroxypropylcellulose; Nanocrystals; Redispersibility; Spray-freeze-drying