title: Language mapping in children using resting-state functional connectivity: comparison with a task-based approach.
abstract: Patients with brain tumor or refractory epilepsy may be candidates for neurosurgery. Presurgical evaluation often includes language investigation to prevent or reduce the risk of postsurgical language deficits. Current techniques involve significant limitations with pediatric populations. Recently, near-infrared spectroscopy (NIRS) has been shown to be a valuable neuroimaging technique for language localization in children. However, it typically requires the child to perform a task (task-based NIRS), which may constitute a significant limitation. Resting-state functional connectivity NIRS (fcNIRS) is an approach that can be used to identify language networks at rest. This study aims to assess the utility of fcNIRS in children by comparing fcNIRS to more conventional task-based NIRS for language mapping in 33 healthy participants: 25 children (ages 3 to 16) and 8 adults. Data were acquired at rest and during a language task. Results show very good concordance between both approaches for language localization (Dice similarity coefficient = 0.81 ± 0.13 ) and hemispheric language dominance ( kappa = 0.86 , p < 0.006 ). The fcNIRS technique may be a valuable tool for language mapping in clinical populations, including children and patients with cognitive and behavioral impairments.
authors.affiliation: CHU Sainte-Justine Research Center, Laboratoire d'Imagerie Optique en Neurodéveloppement (LIONLab), 3175 Chemin de la Côte-Sainte-Catherine, Montréal, Québec H3T 1C5, CanadabUniversité de Montréal, Centre de Recherche en Neuropsychologie et Cognition, Department of Psychology, Marie-Victorin Building, P.O. Box 6128 Centre-ville Station, 2900 Boulevard Édouard-Montpetit, Montréal, Québec H3T 1J4, Canada.
authors.forename: Anne
authors.initials: A
authors.lastname: Gallagher
authors.affiliation: CHU Sainte-Justine Research Center, Laboratoire d'Imagerie Optique en Neurodéveloppement (LIONLab), 3175 Chemin de la Côte-Sainte-Catherine, Montréal, Québec H3T 1C5, CanadabUniversité de Montréal, Centre de Recherche en Neuropsychologie et Cognition, Department of Psychology, Marie-Victorin Building, P.O. Box 6128 Centre-ville Station, 2900 Boulevard Édouard-Montpetit, Montréal, Québec H3T 1J4, Canada.
authors.forename: Julie
authors.initials: J
authors.lastname: Tremblay
authors.affiliation: CHU Sainte-Justine Research Center, Laboratoire d'Imagerie Optique en Neurodéveloppement (LIONLab), 3175 Chemin de la Côte-Sainte-Catherine, Montréal, Québec H3T 1C5, CanadabUniversité de Montréal, Centre de Recherche en Neuropsychologie et Cognition, Department of Psychology, Marie-Victorin Building, P.O. Box 6128 Centre-ville Station, 2900 Boulevard Édouard-Montpetit, Montréal, Québec H3T 1J4, Canada.
authors.forename: Phetsamone
authors.initials: P
authors.lastname: Vannasing
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging / Q000502:physiology; D001931:Brain Mapping / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007802:Language; D008297:Male; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D013060:Speech / Q000502:physiology*; D055815:Young Adult