title: NIR Light-Activated Drug Release for Synergetic Chemo-Photothermal Therapy.
abstract: Nanocarriers like PEGylated liposomes have achieved enhanced drug accumulation in tumors and reduced systemic side effects, but failed to actively release the carried drug into cancer cells. To obtain improved therapeutic efficacy, we designed a novel liposome that was inserted by the amphiphilic agent PEG-IR780-C13 (PIC-Lipo) and encapsulated therapeutic agent doxorubicin (DOX), termed as DOX@PIC-Lipo. Upon NIR laser irradiation, the novel liposomes could generate hyperthermia and facilitate the release of encapsulated DOX from PIC-Lipo, which were confirmed by photothermal curves and the DOX release assay in vitro, respectively. In addition, the enhanced DOX release and sufficient hyperthermia have performed synergetic therapeutic efficacy both in vitro and in vivo. Therefore, DOX@PIC-Lipo might provide an active strategy to release the loaded drug for synergetic chemo-photothermal combined therapy.
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology, Medical School of Nanjing University , Nanjing 210093, China.|Institute of Drug R&D, Medical School of Nanjing University , Nanjing 210093, China.|Jiangsu R&D Platform for Controlled & Targeted Drug Delivery, Nanjing University , Nanjing 210093, China.
authors.forename: Ahu
authors.initials: A
authors.lastname: Yuan
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology, Medical School of Nanjing University , Nanjing 210093, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Huan
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology, Medical School of Nanjing University , Nanjing 210093, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology, Medical School of Nanjing University , Nanjing 210093, China.
authors.forename: Zhicheng
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology, Medical School of Nanjing University , Nanjing 210093, China.
authors.forename: Yifan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology, Medical School of Nanjing University , Nanjing 210093, China.|Institute of Drug R&D, Medical School of Nanjing University , Nanjing 210093, China.|Jiangsu R&D Platform for Controlled & Targeted Drug Delivery, Nanjing University , Nanjing 210093, China.
authors.forename: Jinhui
authors.identifier: 0000-0003-3087-7367
authors.initials: J
authors.lastname: Wu
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology, Medical School of Nanjing University , Nanjing 210093, China.|Institute of Drug R&D, Medical School of Nanjing University , Nanjing 210093, China.|Jiangsu R&D Platform for Controlled & Targeted Drug Delivery, Nanjing University , Nanjing 210093, China.
authors.forename: Yiqiao
authors.initials: Y
authors.lastname: Hu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D003131:Combined Modality Therapy / Q000379:methods; D004317:Doxorubicin / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry; D065546:Drug Liberation / Q000502:physiology; D004357:Drug Synergism; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods; D008027:Light; D008081:Liposomes / Q000737:chemistry; D061986:MCF-7 Cells; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D053758:Nanoparticles / Q000737:chemistry; D010789:Phototherapy / Q000379:methods; D011092:Polyethylene Glycols / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D008081:Liposomes; D011092:Polyethylene Glycols; D004317:Doxorubicin
keywords: NIR light; activatable; chemo−photothermal therapy; doxorubicin; liposome