title: Covalent inhibition of carboxylesterase-2 by sofosbuvir and its effect on the hydrolytic activation of tenofovir disoproxil.
authors.affiliation: Department of Biomedical Sciences, Center for Integrated Drug Development, University of Rhode Island, Kingston, RI 02881, USA.
authors.forename: Yuanjun
authors.initials: Y
authors.lastname: Shen
authors.affiliation: Department of Biomedical Sciences, Center for Integrated Drug Development, University of Rhode Island, Kingston, RI 02881, USA. Electronic address: byan@uri.edu.
authors.forename: Bingfang
authors.initials: B
authors.lastname: Yan
mesh_terms: D019380:Anti-HIV Agents / Q000494:pharmacology; D000998:Antiviral Agents / Q000494:pharmacology; D043182:Carboxylesterase / Q000378:metabolism*; D002265:Carboxylic Ester Hydrolases / Q000378:metabolism*; D002458:Cell Fractionation; D002853:Chromatography, Liquid; D004347:Drug Interactions; D006801:Humans; D006868:Hydrolysis / Q000187:drug effects; D007668:Kidney / Q000473:pathology / Q000648:ultrastructure; D008862:Microsomes, Liver / Q000378:metabolism*; D000069474:Sofosbuvir / Q000494:pharmacology*; D000068698:Tenofovir / Q000494:pharmacology*
chemical_list: D019380:Anti-HIV Agents; D000998:Antiviral Agents; D000068698:Tenofovir; D002265:Carboxylic Ester Hydrolases; C474609:CES1 protein, human; C517204:CES2 protein, human; D043182:Carboxylesterase; D000069474:Sofosbuvir