title: Severe Thrombocytopenia and Acute Cytomegalovirus Colitis during Primary Human Immunodeficiency Virus Infection.
abstract: We herein report the case of a 25-year-old man who was referred to our hospital due to acute cytomegalovirus (CMV) colitis. The initial blood tests showed that the patient had concurrent primary human immunodeficiency virus (HIV) infection and severe thrombocytopenia. Raltegravir-based antiretroviral therapy (ART) was initiated without the use of ganciclovir or corticosteroids and resulted in a rapid clinical improvement. Platelet transfusions were only necessary for a short period, and subsequent colonoscopy revealed a completely healed ulcer. This case implies that ART alone could be effective for treating severe thrombocytopenia during primary HIV and CMV coinfection.
authors.affiliation: Department of Infectious Diseases, Tokyo Metropolitan Komagome Hospital, Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Furuhata
authors.forename: Naoki
authors.initials: N
authors.lastname: Yanagisawa
authors.forename: Shingo
authors.initials: S
authors.lastname: Nishiki
authors.forename: Shugo
authors.initials: S
authors.lastname: Sasaki
authors.forename: Akihiko
authors.initials: A
authors.lastname: Suganuma
authors.forename: Akifumi
authors.initials: A
authors.lastname: Imamura
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ajisawa
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D060085:Coinfection / Q000188:drug therapy; D003092:Colitis / Q000150:complications* / Q000188:drug therapy / Q000821:virology*; D003113:Colonoscopy; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D015774:Ganciclovir; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D008297:Male; D017713:Platelet Transfusion; D000068898:Raltegravir Potassium / Q000627:therapeutic use; D013921:Thrombocytopenia / Q000150:complications* / Q000188:drug therapy* / Q000628:therapy; D016896:Treatment Outcome
chemical_list: D019380:Anti-HIV Agents; D000068898:Raltegravir Potassium; D015774:Ganciclovir