title: Antimicrobial peptide LL-37 participates in the transcriptional regulation of melanoma cells.
abstract: Antimicrobial peptides are an ancient family of molecules that emerged millions of years ago and have been strongly conserved during the evolutionary process of living organisms. Recently, our group described that the human antimicrobial peptide LL-37 migrates to the nucleus, raising the possibility that LL-37 could directly modulate transcription under certain conditions. Here, we showed evidence that LL-37 binds to gene promoter regions, and LL-37 gene silencing changed the transcriptional program of melanoma A375 cells genes associated with histone, metabolism, cellular stress, ubiquitination and mitochondria.
authors.affiliation: Departamento de Análises Clínicas e Toxicológicas, Instituto de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, Brazil.
authors.forename: Mindy
authors.initials: M
authors.lastname: Muñoz
authors.affiliation: Active Motif Incorporation, Carlsbad, California, USA.
authors.forename: Madeleine
authors.initials: M
authors.lastname: Craske
authors.affiliation: Instituto Israelita de Ensino e Pesquisa, Hospital Israelita Albert Einstein, São Paulo, Brazil.
authors.forename: Patricia
authors.initials: P
authors.lastname: Severino
authors.affiliation: Departamento de Emergências Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
authors.forename: Thais Martins
authors.initials: TM
authors.lastname: de Lima
authors.affiliation: Active Motif Incorporation, Carlsbad, California, USA.
authors.forename: Paul
authors.initials: P
authors.lastname: Labhart
authors.affiliation: Departamento de Oncologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
authors.forename: Roger
authors.initials: R
authors.lastname: Chammas
authors.affiliation: Departamento de Emergências Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
authors.forename: Irineu Tadeu
authors.initials: IT
authors.lastname: Velasco
authors.affiliation: Departamento de Emergências Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
authors.forename: Marcel Cerqueira César
authors.initials: MC
authors.lastname: Machado
authors.affiliation: Active Motif Incorporation, Carlsbad, California, USA.
authors.forename: Brian
authors.initials: B
authors.lastname: Egan
authors.affiliation: Departamento de Análises Clínicas e Toxicológicas, Instituto de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, Brazil.
authors.forename: Helder I
authors.initials: HI
authors.lastname: Nakaya
authors.affiliation: Departamento de Emergências Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
authors.forename: Fabiano
authors.initials: F
authors.lastname: Pinheiro da Silva
keywords: LL-37; antimicrobial peptides; cancer.; transcription factors