title: Mesoporous hydroxyapatite nanoparticles hydrothermally synthesized in aqueous solution with hexametaphosphate and tea polyphenols.
abstract: Mesoporous hydroxyapatite (HA) nanoparticles with high surface area have been widely investigated for drug delivery. Herein we report a facile and simple strategy for the preparation of such materials using hexametaphosphate salt as inorganic phosphorus source. In the hydrothermal processing, hexametaphosphate plays an important role in the formation of mesoporous structure. The as-prepared mesoporous HA nanoparticles can be candidates for pH-responsive anticancer drug delivery by using doxorubicin (Dox) as a model drug. Furthermore, modification of these mesoporous HA nanoparticles using tea polyphenols is attempted. The presence of tea polyphenols in the HA synthesis processing result in mesoporous HA nanoparticles with tailored morphology and properties, making them more pH-sensitive for drug delivery. Both hexametaphosphate and tea polyphenols can be potential chemical sources in synthesizing mesoporous HA.
authors.affiliation: Institute of Biomedical Engineering and Health Sciences, Changzhou University, Changzhou, Jiangsu 213164, China; International Research Centre for Translational Orthopedics (IRCTO), Suzhou, Jiangsu 215006, China. Electronic address: huanzhou@cczu.edu.cn.
authors.forename: Huan
authors.initials: H
authors.lastname: Zhou
authors.affiliation: Institute of Biomedical Engineering and Health Sciences, Changzhou University, Changzhou, Jiangsu 213164, China; School of Pharmaceutical Engineering and Life Science, Changzhou University, Changzhou, Jiangsu 213164, China.
authors.forename: Mengmeng
authors.initials: M
authors.lastname: Yang
authors.affiliation: Institute of Biomedical Engineering and Health Sciences, Changzhou University, Changzhou, Jiangsu 213164, China; School of Materials Science and Engineering, Changzhou University, Changzhou, Jiangsu 213164, China.
authors.forename: Saisai
authors.initials: S
authors.lastname: Hou
authors.affiliation: Institute of Biomedical Engineering and Health Sciences, Changzhou University, Changzhou, Jiangsu 213164, China. Electronic address: dlh@cczu.edu.cn.
authors.forename: Linhong
authors.initials: L
authors.lastname: Deng
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry; D028241:Camellia sinensis / Q000737:chemistry*; D004317:Doxorubicin / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D017886:Durapatite / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D053758:Nanoparticles / Q000737:chemistry*; D010710:Phosphates / Q000737:chemistry*; D059808:Polyphenols / Q000737:chemistry*; D016062:Porosity
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D010710:Phosphates; D059808:Polyphenols; C005035:hexametaphosphate; D004317:Doxorubicin; D017886:Durapatite
keywords: Doxorubicin; Hexametaphosphate; Hydroxyapatite; Mesoporous; Tea polyphenols