title: Patient-Reported Self-Efficacy, Anxiety, and Health-Related Quality of Life During Chemotherapy: Results From a Longitudinal Study.
abstract: To explore changes over time in self-efficacy and the predictive ability of changes in state anxiety and health-related quality of life during chemotherapy. .
  
  
  
  Secondary analysis of a longitudinal dataset derived from a larger, multicenter study. .
  
  
  
  Outpatient oncology clinics across eight general hospitals in England, Scotland, and Northern Ireland. .
  
  
  
  137 patients scheduled to receive adjuvant chemotherapy for breast or colorectal cancer. .
  
  
  
  At the beginning of each of six chemotherapy cycles, participants completed the Strategies Used by People to Promote Health questionnaire, the State-Trait Anxiety Inventory, and the Functional Assessment of Cancer Therapy-Breast or -Colorectal questionnaire. Multilevel model analysis was used to analyze longitudinal data, adjusted for demographic and clinical variables. .
  
  
  
  Self-efficacy, anxiety, and health-related quality of life. .
  
  
  
  No significant time effects were found for patients' overall perceived self-efficacy or self-efficacy parameters. A trend toward greater self-efficacy was evident as chemotherapy progressed. Self-efficacy was significantly associated with decreased state anxiety throughout chemotherapy. Increases in overall self-efficacy and perceived ability to maintain a positive attitude were significantly associated with over-time increases in physical, emotional, and functional well-being, as well as with fewer cancer-related concerns. .
  
  
  
  Findings highlight the importance of clinical assessments throughout treatment that focus on patients' perceived self-efficacy as a positive regulator of mood and well-being.  .
  
  
  
  The current study suggests self-efficacy enhancement should be a key component of psycho-behavioral programs designed to support patients with cancer throughout chemotherapy.
authors.affiliation: University of the West of Scotland.
authors.forename: Constantina
authors.initials: C
authors.lastname: Papadopoulou
authors.affiliation: University of Surrey.
authors.forename: Grigorios
authors.initials: G
authors.lastname: Kotronoulas
authors.affiliation: University of Surrey.
authors.forename: Annegret
authors.initials: A
authors.lastname: Schneider
authors.affiliation: University of Surrey.
authors.forename: Morven I
authors.initials: MI
authors.lastname: Miller
authors.affiliation: University of Surrey.
authors.forename: Jackie
authors.initials: J
authors.lastname: McBride
authors.affiliation: University of Surrey.
authors.forename: Zoe
authors.initials: Z
authors.lastname: Polly
authors.affiliation: University of Surrey.
authors.forename: Simon
authors.initials: S
authors.lastname: Bettles
authors.affiliation: University of Surrey.
authors.forename: Alison
authors.initials: A
authors.lastname: Whitehouse
authors.affiliation: University of Surrey.
authors.forename: Lisa
authors.initials: L
authors.lastname: McCann
authors.affiliation: University of Surrey.
authors.forename: Nora
authors.initials: N
authors.lastname: Kearney
authors.affiliation: University of Surrey.
authors.forename: Roma
authors.initials: R
authors.lastname: Maguire
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001007:Anxiety / Q000523:psychology*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000523:psychology*; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000523:psychology*; D004358:Drug Therapy / Q000523:psychology*; D004739:England; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009660:Northern Ireland; D011788:Quality of Life / Q000523:psychology*; D012606:Scotland; D020377:Self Efficacy; D057566:Self Report
keywords: anxiety; chemotherapy ; health-related quality of life; longitudinal; self-efficacy