title: Cutting Edge: Murine Mast Cells Rapidly Modulate Metabolic Pathways Essential for Distinct Effector Functions.
abstract: There is growing appreciation that cellular metabolic and bioenergetic pathways do not play merely passive roles in activated leukocytes. Rather, metabolism has important roles in controlling cellular activation, differentiation, survival, and effector function. Much of this work has been performed in T cells; however, there is still very little information regarding mast cell metabolic reprogramming and its effect on cellular function. Mast cells perform important barrier functions and help control type 2 immune responses. In this study we show that murine bone marrow-derived mast cells rapidly alter their metabolism in response to stimulation through the FcεRI. We also demonstrate that specific metabolic pathways appear to be differentially required for the control of mast cell function. Manipulation of metabolic pathways may represent a novel point for the manipulation of mast cell activation.
authors.affiliation: Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261.|Immunology Graduate Program, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261.
authors.forename: Binh
authors.initials: B
authors.lastname: Phong
authors.affiliation: Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261.|Infectious Disease and Microbiology Graduate Program, University of Pittsburgh School of Public Health, Pittsburgh, PA 15261.
authors.forename: Lyndsay
authors.initials: L
authors.lastname: Avery
authors.affiliation: Tumor Microenvironment Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261; and.
authors.forename: Ashley V
authors.initials: AV
authors.lastname: Menk
authors.affiliation: Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261.|Immunology Graduate Program, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261.|Tumor Microenvironment Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261; and.|Cancer Immunology Program, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261.
authors.forename: Greg M
authors.initials: GM
authors.lastname: Delgoffe
authors.affiliation: Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261; lkane@pitt.edu.|Immunology Graduate Program, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261.|Cancer Immunology Program, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261.
authors.forename: Lawrence P
authors.identifier: 0000-0001-5198-516X
authors.initials: LP
authors.lastname: Kane
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000276:immunology; D002478:Cells, Cultured; D008407:Mast Cells / Q000276:immunology* / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL