title: Engineering Intrinsically Zirconium-89 Radiolabeled Self-Destructing Mesoporous Silica Nanostructures for In Vivo Biodistribution and Tumor Targeting Studies.
abstract: A systematic study of in vitro and in vivo behavior of biodegradable mesoporous silica nanoparticles (bMSNs), designed to carry multiple cargos (both small and macromolecular drugs) and subsequently self-destruct following release of their payloads, is presented. Complete degradation of bMSNs is seen within 21 d of incubation in simulated body fluid. The as-synthesized bMSNs are intrinsically radiolabeled with oxophilic zirconium-89 (89Zr,t1/2= 78.4 h) radionuclide to track their in vivo pharmacokinetics via positron emission tomography imaging. Rapid and persistent CD105 specific tumor vasculature targeting is successfully demonstrated in murine model of metastatic breast cancer by using TRC105 (an anti-CD105 antibody)-conjugated bMSNs. This study serves to illustrate a simple, versatile, and readily tunable approach to potentially overcome the current challenges facing nanomedicine and further the goals of personalized nanotheranostics.
authors.affiliation: Materials Science Program University of Wisconsin-Madison Madison WI 53705 USA.
authors.forename: Shreya
authors.initials: S
authors.lastname: Goel
authors.affiliation: Department of Radiology University of Wisconsin-Madison Madison WI 53705 USA.
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
authors.affiliation: School of Pharmacy Temple University Philadelphia PA 19140 USA.
authors.forename: Shijie
authors.initials: S
authors.lastname: Luan
authors.affiliation: Department of Medical Physics University of Wisconsin-Madison Madison WI 53705 USA.
authors.forename: Hector F
authors.initials: HF
authors.lastname: Valdovinos
authors.affiliation: Materials Science Program University of Wisconsin-Madison Madison WI 53705 USA.
authors.forename: Sixiang
authors.initials: S
authors.lastname: Shi
authors.affiliation: Department of Medical Physics University of Wisconsin-Madison Madison WI 53705 USA.
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Graves
authors.affiliation: Department of Radiology University of Wisconsin-Madison Madison WI 53705 USA.
authors.forename: Fanrong
authors.initials: F
authors.lastname: Ai
authors.affiliation: Department of Medical Physics University of Wisconsin-Madison Madison WI 53705 USA.
authors.forename: Todd E
authors.initials: TE
authors.lastname: Barnhart
authors.affiliation: TRACON Pharmaceuticals Inc San Diego CA 92122 USA.
authors.forename: Charles P
authors.initials: CP
authors.lastname: Theuer
authors.affiliation: Materials Science Program University of Wisconsin-Madison Madison WI 53705 USA; Department of Radiology University of Wisconsin-Madison Madison WI 53705 USA; Department of Medical Physics University of Wisconsin-Madison Madison WI 53705 USA; University of Wisconsin Carbone Cancer Centre Madison WI 53705 USA.
authors.forename: Weibo
authors.initials: W
authors.lastname: Cai
keywords: biodegradable mesoporous silica nanoparticles; intrinsic radiolabeling; positron emission tomography (PET) imaging; vasculature targeting