title: [Lung screening].
abstract: The NLST study found in more than 53,000 (former-) heavy smokers that annual screening with low-dose CT-scan (LDCT) reduced lung cancer mortality and overall mortality by 20% and 6.7% respectively. However, several potential harms of such screening strategy were underlined: over-diagnosis bias, irradiation risk, and the high rate of false-positive results that could lead to futile invasive (and potentially harmful) exams, to impact quality of life, to increase patient's anxiety and costs. All these concerns were largely debated in several recent publications. Most of them concluded in a risk/benefit ratio favoring screening strategy by LDCT. Conversely, most of American academic societies currently recommend LDCT-based lung cancer screening. In France, a taskforce edited a common statement recommending screening smokers or ex-smokers, from 55 to 75years old who have smoked at least 30packs/year. The taskforce also underlined the need for clinical trials aiming to translate screening strategy to the French setting. However, the French Health Authority recently claimed that lung cancer screening was not relevant in the current setting.
authors.affiliation: Service de pneumologie, hôpital Tenon, AP-HP, 75020 Paris, France; Service d'oncologie thoracique, CIC 1425, CLIP2 Paris-Nord, hôpital Bichat, AP-HP, 75018 Paris, France. Electronic address: bernard.milleron@orange.fr.
authors.forename: B
authors.initials: B
authors.lastname: Milleron
authors.affiliation: Service d'oncologie thoracique, CIC 1425, CLIP2 Paris-Nord, hôpital Bichat, AP-HP, 75018 Paris, France.
authors.forename: V
authors.initials: V
authors.lastname: Gounant
authors.affiliation: Service de radiologie, hôpital Bichat, AP-HP, 75018 Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Khalil
authors.affiliation: Service de pneumologie aiguë spécialisée et cancérologie thoracique, centre hospitalier Lyon Sud, institut de cancérologie des hospices civils de Lyon, 69495 Pierre-Bénite, France; EMR 3738 ciblage thérapeutique en oncologie, faculté de médecine et de maïeutique Lyon Sud Charles-Mérieux, université Lyon 1, 69600 Oullins, France.
authors.forename: S
authors.initials: S
authors.lastname: Couraud
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood; D003952:Diagnostic Imaging / Q000379:methods; D055088:Early Detection of Cancer / Q000379:methods*; D005189:False Positive Reactions; D005602:France; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000453:epidemiology; D008403:Mass Screening / Q000379:methods*; D012907:Smoking / Q000009:adverse effects / Q000453:epidemiology
chemical_list: D014408:Biomarkers, Tumor
keywords: Cancer bronchopulmonaire; Dépistage; Low-dose CT-scan; Lung cancer; Scanner faiblement dosé; Screening