title: Effects of (-)-Sesamin on Chronic Stress-Induced Anxiety Disorders in Mice.
abstract: This study investigated the effects of (-)-sesamin on chronic electric footshock (EF) stress-induced anxiety disorders in mice. Mice were treated with (-)-sesamin (25 and 50 mg/kg) orally once a day for 21 days prior to exposure to EF stress (0.6 mA, 1 s every 5 s, 3 min). Mice treated with (-)-sesamin (25 and 50 mg/kg) exhibited less severe decreases in the number of open arm entries and time spent on open arms in the elevated plus-maze test and the distance traveled in the open field test following exposure to chronic EF stress. Similarly, mice treated with (-)-sesamin exhibited significantly less severe decreases in brain levels of dopamine, norepinephrine, and serotonin following exposure to chronic EF stress. Increases in serum levels of corticosterone and expression of c-Fos were also less pronounced in mice treated with (-)-sesamin (25 and 50 mg/kg). These results suggest that (-)-sesamin may protect against the effects of chronic EF stress-induced anxiety disorders by modulating dopamine, norepinephrine, and serotonin levels, c-Fos expression, and corticosterone levels.
authors.affiliation: Department of Pharmacy, Chungbuk National University, Cheongju, 28644, Republic of Korea.|Research Center for Bioresource and Health, College of Pharmacy, Chungbuk National University, Cheongju, 28644, Republic of Korea.
authors.forename: Ting Ting
authors.initials: TT
authors.lastname: Zhao
authors.affiliation: Department of Pharmacy, Chungbuk National University, Cheongju, 28644, Republic of Korea.
authors.forename: Keon Sung
authors.initials: KS
authors.lastname: Shin
authors.affiliation: Department of Pharmacy, Chungbuk National University, Cheongju, 28644, Republic of Korea.|Research Center for Bioresource and Health, College of Pharmacy, Chungbuk National University, Cheongju, 28644, Republic of Korea.
authors.forename: Hyun Jin
authors.initials: HJ
authors.lastname: Park
authors.affiliation: Department of Pharmacy, Chungbuk National University, Cheongju, 28644, Republic of Korea.
authors.forename: Bo Ram
authors.initials: BR
authors.lastname: Yi
authors.affiliation: Department of Pharmacy, Chungbuk National University, Cheongju, 28644, Republic of Korea.
authors.forename: Kyung Eun
authors.initials: KE
authors.lastname: Lee
authors.affiliation: Department of Pharmacy, Chungbuk National University, Cheongju, 28644, Republic of Korea. myklee@chungbuk.ac.kr.|Research Center for Bioresource and Health, College of Pharmacy, Chungbuk National University, Cheongju, 28644, Republic of Korea. myklee@chungbuk.ac.kr.
authors.forename: Myung Koo
authors.initials: MK
authors.lastname: Lee
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology / Q000627:therapeutic use*; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use; D001008:Anxiety Disorders / Q000188:drug therapy* / Q000378:metabolism; D015306:Biogenic Monoamines / Q000378:metabolism; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002908:Chronic Disease; D003345:Corticosterone / Q000378:metabolism; D004149:Dioxoles / Q000494:pharmacology / Q000627:therapeutic use*; D017705:Lignans / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D013315:Stress, Psychological / Q000188:drug therapy* / Q000378:metabolism; D016896:Treatment Outcome
chemical_list: D014151:Anti-Anxiety Agents; D000975:Antioxidants; D015306:Biogenic Monoamines; D004149:Dioxoles; D017705:Lignans; C054125:sesamin; D003345:Corticosterone
keywords: (−)-Sesamin; Anxiety-like disorders; Chronic stress; Corticosterone; Dopamine and norepinephrine; Serotonin; c-Fos