title: Five Pediatric Cancers - Update on Genetic Implications.
abstract: Pediatric cancer has undergone significant improvements in survival over the past several decades, in part due to a better understanding of the underlying genetic aberrations of each oncologic diagnosis, which has allowed for more effective targeted therapies. Pediatric brain tumors, leukemia, lymphoma, Wilms tumor, and retinoblastoma are exemplary pediatric cancers that each has specific epidemiology regarding children at risk as well as characteristic associated genetic lesions. These genetic features are more commonly being used to provide risk stratification, as well as to identify novel pathways for targeted therapy. With these advances, the overall survival of pediatric cancers continues to be improved.
authors.affiliation: Departments of Oncology and Pediatrics, Sidney Kimmel Comprehensive Cancer, Center and Johns Hopkins University, School of Medicine, 1650 Orleans Street, CRB1 Room 2M49, Baltimore, MD 21231. United States.
authors.forename: Stacy
authors.initials: S
authors.lastname: Cooper
authors.affiliation: Division of Pediatric Oncology, Johns Hopkins Hospital, 1800 Orleans St, Bloomberg 11379, Baltimore, MD 21287. United States.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Rubens
authors.affiliation: McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins School of Medicine, 600 N. Wolfe St., Blalock 1008, Baltimore MD 21287. United States.
authors.forename: Joann
authors.initials: J
authors.lastname: Bodurtha
mesh_terms: D001932:Brain Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000628:therapy; D002648:Child; D005820:Genetic Testing / Q000379:methods; D006801:Humans; D007938:Leukemia / Q000453:epidemiology / Q000235:genetics* / Q000628:therapy; D008223:Lymphoma / Q000453:epidemiology / Q000235:genetics* / Q000628:therapy; D058990:Molecular Targeted Therapy / Q000379:methods; D010372:Pediatrics; D012175:Retinoblastoma / Q000453:epidemiology / Q000235:genetics* / Q000628:therapy; D009396:Wilms Tumor / Q000453:epidemiology / Q000235:genetics* / Q000628:therapy
keywords: Brain tumors; cancer; genetics; leukemia; lymphoma; pediatrics; retinoblastoma; wilms tumor