title: Antibacterial Action of Curcumin againstStaphylococcus aureus: A Brief Review.
abstract: Curcumin, the major constituent ofCurcuma longaL. (Zingiberaceae family) or turmeric, commonly used for cooking in Asian cuisine, is known to possess a broad range of pharmacological properties at relatively nontoxic doses. Curcumin is found to be effective againstStaphylococcus aureus(S. aureus). As demonstrated byin vitroexperiment, curcumin exerts even more potent effects when used in combination with various other antibacterial agents. Hence, curcumin which is a natural product derived from plant is believed to have profound medicinal benefits and could be potentially developed into a naturally derived antibiotic in the future. However, there are several noteworthy challenges in the development of curcumin as a medicine.S. aureusinfections, particularly those caused by the multidrug-resistant strains, have emerged as a global health issue and urgent action is needed. This review focuses on the antibacterial activities of curcumin against both methicillin-sensitiveS. aureus(MSSA) and methicillin-resistantS. aureus(MRSA). We also attempt to highlight the potential challenges in the effort of developing curcumin into a therapeutic antibacterial agent.
authors.affiliation: Sunway Institute for Healthcare Development (SIHD), Sunway University, 47500 Bandar Sunway, Selangor Darul Ehsan, Malaysia.
authors.forename: Sin-Yeang
authors.identifier: 0000-0002-3824-0224
authors.initials: SY
authors.lastname: Teow
authors.affiliation: Molecular Pathology Unit, Cancer Research Centre (CaRC), Institute for Medical Research (IMR), 50588 Jalan Pahang, Kuala Lumpur, Malaysia.
authors.forename: Kitson
authors.initials: K
authors.lastname: Liew
authors.affiliation: Advanced Medical and Dental Institute (AMDI), Universiti Sains Malaysia (USM), 13200 Kepala Batas, Pulau Pinang, Malaysia.
authors.forename: Syed A
authors.initials: SA
authors.lastname: Ali
authors.affiliation: Molecular Pathology Unit, Cancer Research Centre (CaRC), Institute for Medical Research (IMR), 50588 Jalan Pahang, Kuala Lumpur, Malaysia; Institute for Research, Development and Innovation, International Medical University (IMU), 57000 Bukit Jalil, Kuala Lumpur, Malaysia.
authors.forename: Alan Soo-Beng
authors.initials: AS
authors.lastname: Khoo
authors.affiliation: Sunway Institute for Healthcare Development (SIHD), Sunway University, 47500 Bandar Sunway, Selangor Darul Ehsan, Malaysia; Anatomical Pathology Department, Sunway Medical Centre, 47500 Bandar Sunway, Selangor Darul Ehsan, Malaysia.
authors.forename: Suat-Cheng
authors.initials: SC
authors.lastname: Peh