title: Microbiota Small RNAs in Inflammatory Bowel Disease.
abstract: MiRNAs are a class of potential gene regulators of critical importance in Inflammatory Bowel Disease (IBD). This review aims to present the connection between gut microbiota, probiotics administration and microRNA (miRNA) expression in IBD. It also brings into question cross-kingdom RNAi (RNA interference). Not only that gut host cells garden the intestinal microbiome via miRNA, but also strong evidence supports the idea that different species of bacteria have an impact on the intestinal immune response by modulating miRNA expression. Cross-kingdom RNAi refers to RNA silencing signals that travel between two unrelated, interacting organisms. RNAs communication between prokaryotes and eukaryotes (bacteria and nematodes) via RNAs transfer has been proved. Some authors also support the idea that non-coding RNAs are being transferred by bacterial pathogens to the host cells as part of the intracellular infection process. Further studies are required in order to clarify whether the mechanism by which bacteria modulate miRNA expression concerns RNAs transfer. These findings may lead to a different approach to IBD therapy in the future.
authors.affiliation: Biochemistry Department, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
authors.forename: Anca T
authors.initials: AT
authors.lastname: Filip
authors.affiliation: Department of Functional Genomics, Proteomics and Experimental Pathology, Prof. Dr. I. Chiricuta Oncology Institute, Cluj-Napoca, Romania.
authors.forename: Ovidiu
authors.initials: O
authors.lastname: Balacescu
authors.affiliation: Biochemistry Department, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
authors.forename: Catalin
authors.initials: C
authors.lastname: Marian
authors.affiliation: Biochemistry Department, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania. biochim@umft.ro.
authors.forename: Andrei
authors.initials: A
authors.lastname: Anghel
mesh_terms: D000818:Animals; D001419:Bacteria / Q000235:genetics*; D000069196:Gastrointestinal Microbiome; D015964:Gene Expression Regulation, Bacterial; D054884:Host-Pathogen Interactions; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000175:diagnosis / Q000235:genetics / Q000382:microbiology* / Q000628:therapy; D007422:Intestines / Q000382:microbiology*; D035683:MicroRNAs / Q000235:genetics*; D019936:Probiotics / Q000627:therapeutic use; D034622:RNA Interference; D012329:RNA, Bacterial / Q000235:genetics*
chemical_list: D035683:MicroRNAs; D012329:RNA, Bacterial