title: The DSF Family of Quorum Sensing Signals: Diversity, Biosynthesis, and Turnover.
abstract: The diffusible signaling factor (DSF)-based quorum sensing (QS) system has emerged as a widely conserved cell-cell communication mechanism in Gram-negative bacteria. Typically, signals from the DSF family are cis-2-unsaturated fatty acids which regulate diverse biological functions. Recently, substantial progress has been made on the characterization of new members of this family of signals. There have also been new developments in the understanding of the biosynthesis of these molecules where dual enzymatic activities of the DSF synthase and the use of various substrates have been described. The recent discovery of a naturally occurring DSF turnover mechanism and its regulation provides a new dimension in our understanding of how DSF-dependent microorganisms modulate virulence gene expression in response to changes in the surrounding environment.
authors.affiliation: State Key Laboratory of Microbial Metabolism, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
authors.forename: Lian
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Guangdong Province Key Laboratory of Microbial Signals and Disease Control, State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, South China Agricultural University, Guangzhou 510642, China.
authors.forename: Lian-Hui
authors.initials: LH
authors.lastname: Zhang
authors.affiliation: School of Life Sciences, Centre for Biomolecular Sciences, University of Nottingham, Nottingham NG7 2RD, United Kingdom.
authors.forename: Miguel
authors.initials: M
authors.lastname: Cámara
authors.affiliation: State Key Laboratory of Microbial Metabolism, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China. Electronic address: yawenhe@sjtu.edu.cn.
authors.forename: Ya-Wen
authors.initials: YW
authors.lastname: He
mesh_terms: D057508:Burkholderia cenocepacia / Q000472:pathogenicity*; D059126:Cronobacter / Q000472:pathogenicity*; D005227:Fatty Acids / Q000096:biosynthesis; D005229:Fatty Acids, Monounsaturated / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial; D007848:Laurates / Q000378:metabolism*; D053038:Quorum Sensing / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D014774:Virulence; D037521:Virulence Factors / Q000378:metabolism; D016959:Xanthomonas campestris / Q000472:pathogenicity*
chemical_list: C527562:2-dodecenoic acid; D005227:Fatty Acids; D005229:Fatty Acids, Monounsaturated; D007848:Laurates; D037521:Virulence Factors; C089549:lauric acid methyl ester
keywords: DSF; Xanthomonas; biosynthesis; naturally occurring signal turnover; quorum sensing