title: Polymersome Popping by Light-Induced Osmotic Shock under Temporal, Spatial, and Spectral Control.
abstract: The light-triggered, programmable rupture of cell-sized vesicles is described, with particular emphasis on self-assembled polymersome capsules. The mechanism involves a hypotonic osmotic imbalance created by the accumulation of photogenerated species inside the lumen, which cannot be compensated owing to the low water permeability of the membrane. This simple and versatile mechanism can be adapted to a wealth of hydrosoluble molecules, which are either able to generate reactive oxygen species or undergo photocleavage. Ultimately, in a multi-compartmentalized and cell-like system, the possibility to selectively burst polymersomes with high specificity and temporal precision and to consequently deliver small encapsulated vesicles (both polymersomes and liposomes) is demonstrated.
authors.affiliation: Laboratoire de Chimie des Polymères Organiques, LCPO, Université de Bordeaux, CNRS, Bordeaux INP, UMR 5629, 33600, Pessac, France.
authors.forename: Ariane
authors.identifier: 0000-0002-3467-7728
authors.initials: A
authors.lastname: Peyret
authors.affiliation: Laboratoire de Chimie des Polymères Organiques, LCPO, Université de Bordeaux, CNRS, Bordeaux INP, UMR 5629, 33600, Pessac, France.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Ibarboure
authors.affiliation: Institut des Sciences Moléculaires, Université de Bordeaux, CNRS UMR 5255, 33405, Talence, France.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Tron
authors.affiliation: Laboratoire de Chimie des Polymères Organiques, LCPO, Université de Bordeaux, CNRS, Bordeaux INP, UMR 5629, 33600, Pessac, France.
authors.forename: Louis
authors.initials: L
authors.lastname: Beauté
authors.affiliation: Institut des Sciences Moléculaires, Université de Bordeaux, CNRS UMR 5255, 33405, Talence, France.
authors.forename: Ruben
authors.initials: R
authors.lastname: Rust
authors.affiliation: Laboratoire de Chimie des Polymères Organiques, LCPO, Université de Bordeaux, CNRS, Bordeaux INP, UMR 5629, 33600, Pessac, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Sandre
authors.affiliation: Institut des Sciences Moléculaires, Université de Bordeaux, CNRS UMR 5255, 33405, Talence, France.
authors.forename: Nathan D
authors.identifier: 0000-0003-0285-1741
authors.initials: ND
authors.lastname: McClenaghan
authors.affiliation: Laboratoire de Chimie des Polymères Organiques, LCPO, Université de Bordeaux, CNRS, Bordeaux INP, UMR 5629, 33600, Pessac, France.
authors.forename: Sebastien
authors.identifier: 0000-0003-0465-8603
authors.initials: S
authors.lastname: Lecommandoux
keywords: fluorescence; photochemistry; photorelease; polymersomes; self-assembly