title: Relationship Between Genotype Variants Follicle-stimulating Hormone Receptor Gene Polymorphisms (FSHR) and Morphology of Oocytes Prior to ICSI Procedures.
abstract: BACKGROUND
  This study investigated association of Asn680Ser FSHR polymorphism with the ovarian response in 104 women of Albanian ethnic population enrolled in ICSI program. The reason of infertility in all cases has been identified as male factor.
  
  
  METHODS
  Analysis of the Asn680Ser polymorphism was performed using TaqMan®SNP Genotyping Assay. Clinical and endocrinologic parameters were analyzed based on the genotype, age, BMI, oocyte yield, number of transferred embryos and pregnancy rate.
  
  
  RESULTS
  The frequencies of the Asn680 Ser genotype variants were as follows: Asn/Asn 22.1%, Asn/Ser 47.1%, and Ser/Ser 30.8%, respectively. BMI was significantly higher in the Ser/Ser group as compared to those from the Asn/Ser or the Asn/Asn group (p= 0.0010). The genotype variants Ser/Ser indicates a higher rate of oocyte retrieval (25.9%) in the immature form, metaphase I (MI) as opposed to the other two groups (Asn/Asn 23.7 % vs. Asn/Ser 21.9%), which was statistically significant (p = 0.3020).
  
  
  CONCLUSIONS
  FSH receptor polymorphism is associated with different ovarian response to controlled ovarian stimulation (COS), but is not an important factor in increasing the degree of pregnancy. Polymorphisms of the FSH receptor is associated with normal morphology and genetic maturation (metaphase II) oocytes in dependence of genotypic variation polymorphisms.
authors.affiliation: Infertyliti center, Peje, Kosovo.
authors.forename: Zafer
authors.initials: Z
authors.lastname: Gashi
authors.affiliation: Regional Hospital, Peje, Kosovo.
authors.forename: Shkelzen
authors.initials: S
authors.lastname: Elezaj
authors.affiliation: Infertyliti center, Peje, Kosovo.
authors.forename: Afrim
authors.initials: A
authors.lastname: Zeqiraj
authors.affiliation: Mother Teresa" Medical Center Kline, Kosovo.
authors.forename: Driton
authors.initials: D
authors.lastname: Grabanica
authors.affiliation: Ministry of Health Pristina, Kosovo.
authors.forename: Isak
authors.initials: I
authors.lastname: Shabani
authors.affiliation: Faculty of Medicine, University of Prishtina, Prishtine, Kosovo.
authors.forename: Bujar
authors.initials: B
authors.lastname: Gruda
authors.affiliation: Faculty of Medicine, University of Prishtina, Prishtine, Kosovo.
authors.forename: Fitore
authors.initials: F
authors.lastname: Gashi
mesh_terms: D000328:Adult; D005260:Female; D005838:Genotype; D006801:Humans; D063826:Kosovo; D009865:Oocytes / Q000473:pathology*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011962:Receptors, FSH / Q000235:genetics*; D020554:Sperm Injections, Intracytoplasmic
chemical_list: D011962:Receptors, FSH
keywords: AFC; Asn680Ser; FSH; FSHR; ICSI; SNP