title: A Novel Approach Using 15% Natural Chitosan Gel  in the Management of Intrabony Defects: A Pilot Study.
abstract: OBJECTIVE
  To evaluate the effectiveness of 15% chitosan in gel form as a periodontal regenerative material in the periodontal intrabony defects.
  
  
  METHODS
  A pilot study split-mouth design of 10 patients within the age group of 30 to 55 years with bilateral intrabony defects ≥ 3mm and clinical attachment levels (CAL) ≥ 5mm were selected. The test site received open flap debridement with 15% Chitosan gel as a regenerative material and the controlateral side that acted as a control received only open flap debridement. Clinical and radiographic measurements were recorded at baseline, and 3, 6 and 9 months after the treatment.
  
  
  RESULTS
  Data revealed that there was a significant improvement in both clinical and radiographic parameters when intragroup comparison was performed. When intergroup comparison was done, there was a mean difference in CAL (5.8 ± 1.398 mm) and the depth of the intrabony defect (3.41 ± 1.17 mm) at 9 months when compared to baseline.
  
  
  CONCLUSIONS
  Within the limitations of the study, it can be concluded that a 15% concentration of chitosan gel is a promising aid and could be used as an effective material in periodontal regeneration.
authors.forename: Irfana
authors.initials: I
authors.lastname: Babrawala
authors.forename: Prabhuji
authors.initials: P
authors.lastname: Munivenkatappa Lakshmaiah Venkatesh
authors.forename: Karthikeyan
authors.initials: K
authors.lastname: Bangalore Varadhan
mesh_terms: D000328:Adult; D001672:Biocompatible Materials / Q000008:administration & dosage*; D001861:Bone Regeneration; D048271:Chitosan / Q000008:administration & dosage*; D005260:Female; D005782:Gels; D006801:Humans; D007568:Jaw; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects
chemical_list: D001672:Biocompatible Materials; D005782:Gels; D048271:Chitosan