title: Principles of Antibiotic Management of Community-Acquired Pneumonia.
abstract: Community-acquired pneumonia (CAP) encompasses a broad spectrum of disease severity and may require outpatient, inpatient, or intensive care management. Successful treatment hinges on expedient delivery of appropriate antibiotic therapy tailored to both the likely offending pathogens and the severity of disease. This review summarizes key principles in starting treatment and provides recommended empiric therapy regimens for each site of care. In addition, we discuss the antimicrobial and anti-inflammatory role macrolides play in CAP, as well as specific information for managing individual CAP pathogens such as community-acquired methicillin-resistantStaphylococcus aureusand drug-resistantStreptococcus pneumoniae. We also examine several novel antibiotics being developed for CAP and review the evidence guiding duration of therapy and current best practices for the transition of hospitalized patients from intravenous antibiotics to oral therapy.
authors.affiliation: NewYork-Presbyterian Hospital, Weill Cornell Medicine, New York, New York.
authors.forename: Michael T
authors.initials: MT
authors.lastname: Bender
authors.affiliation: Department of Medicine, Weill Cornell Medical College, New York, New York.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Niederman
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D017714:Community-Acquired Infections / Q000188:drug therapy; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus; D018410:Pneumonia, Bacterial / Q000188:drug therapy*; D013296:Streptococcus pneumoniae
chemical_list: D000900:Anti-Bacterial Agents