title: SnapShot: Cartography of Intramembrane Proteolysis.
abstract: Intramembrane proteases hydrolyze peptide bonds within the cell membrane as the decision-making step of various signaling pathways or during general proteostasis. Although initially thought to be rare, fourteen proteases from four superfamilies are now known to be distributed among nearly every membrane compartment of a human cell. Each protease is endowed with specific enzymatic properties that determine both substrate choice and outcome.
authors.affiliation: Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Room 507 PCTB, 725 North Wolfe Street, Baltimore, MD 21205, USA.
authors.forename: Siniša
authors.initials: S
authors.lastname: Urban
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000201:enzymology / Q000378:metabolism*; D006801:Humans; D010447:Peptide Hydrolases / Q000032:analysis* / Q000378:metabolism; D059748:Proteolysis
chemical_list: D010447:Peptide Hydrolases