title: Association Between TNF-α Promoter -308 A/G Polymorphism and Systemic Lupus Erythematosus Susceptibility: A Case-Control Study and Meta-Analysis.
abstract: The tumour necrosis factor-α (TNF-α) promoter -308 A/G polymorphism plays an important role in the aetiology of systemic lupus erythematosus (SLE). Several studies have estimated the association between TNF-α -308 A/G and SLE risk. However, results were inconsistent. A case-control study was carried out to explore the association between TNF-α -308 A/G and the SLE risk in a Chinese Han population. Meta-analysis combining present with previous studies was conducted to further explore the association. Our case-control study included 556 patients with SLE along with 570 matched healthy controls. TNF-α -308 A allele was significantly increased in patients with SLE compared with controls (OR = 2.184, 95% CI: 1.718-2.778, P < 0.001). Genotypes AA and AG were associated with the susceptibility to SLE as compared with the GG genotype, as well as the dominant model (AA+AG versus GG), respectively. The meta-analysis included 41 comparative studies involving 4799 patients and 6635 controls. An association between SLE and allele A was found in the overall populations (OR = 1.70, 95% CI: 1.46-1.98, P < 0.001). In addition, we discussed the correlation between this polymorphism and lupus nephritis (LN) risk, showing that allele A was significantly related to LN in the overall populations (OR = 1.80, 95% CI: 1.21-2.68, P = 0.004). The results from our case-control study and the meta-analysis indicate that the TNF-α -308 A allele is significantly associated with an increased risk of SLE/LN.
authors.affiliation: Department of Rheumatology and Immunology, the Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
authors.forename: Z-C
authors.initials: ZC
authors.lastname: Yang
authors.affiliation: Department of Rheumatology and Immunology, the Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
authors.forename: F
authors.initials: F
authors.lastname: Xu
authors.affiliation: Department of Rheumatology and Immunology, the Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
authors.forename: M
authors.initials: M
authors.lastname: Tang
authors.affiliation: Department of Dermatology, the Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
authors.forename: X
authors.initials: X
authors.lastname: Xiong
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D008181:Lupus Nephritis / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*; D055815:Young Adult
chemical_list: D014409:Tumor Necrosis Factor-alpha