title: [Risk factors for long-term result of endovascular treatment for auto-immune disease related abdominal aorta pseudo-aneurysm].
abstract: Objective:To summarize results of endovascular treatment for auto-immune disease related abdominal aorta pseudo-aneurysm(AIPA), and to analysis clinical predictors of long term major adverse clinical events(MACE).Methods:Retrospectively collected endovascular treatment for AIPA cases in Peking Union Medical College Hospital within 2000 to 2015. Twenty-nine cases with AIPA treated by endovascular therapy were enrolled in this study. Twenty five cases were male, range from 23 to 67 years old, mean age was (39.3±11.4) years old.Demographic characters, locations of aneurysms, type to auto-immune disease, immuno medical therapy, operation strategy and long term follow-up data were reported. Statistical analysis was made to verify clinical predictors of long-term MACE.Results:Among the 29 cases, 22 cases with bechet's disease, 4 cases with Takayasu's arteritis, 2 cases with systemic lupus erythematosus, 1 cases with polyarteritis nodosa. Eight cases had ruptured or pending ruptured pesudo-aneurysms, the rest 21 cases had dull pain or no overt symptome. Twenty-four cases had infra-renal artery aneurysms, two were para-and supra-renal artery, two were supra-celiac artery, and the rest one had multiple aneurysms involved thoracic and abdominal aorta.All the cases received regular immune medical therapy except the three emergency cases. All the operations were under general anaesthesia. Nineteen cases underwent classical Endovascular aortic aneurysm repair (EVAR), 5 cases underwent fenestration EVAR, the rest 5 cases underwent hybrid procedure. All the 29 operations were successful, without conversion to open surgery. Major peri-operation complication included 3 incision infection, 3 pulmonary infection. No death occurred. All the cases received regular follow-up from 1 to 120 months. There were five recurrence of pseudo-aneurysm, 1 case suffered from iliac limb occlusion. 5 cases received re-intervention procedure. No occlusion of revascularizal visceral artery was found during follow-up. There were 3 deaths during follow-up, with 1 aneurysm related death, the rest died due to other reasons. Single factors logical regressions analysis showed discontinuing immune medicine therapy and age no less than 40 years significantly related long-term MACE(P<0.05). Meanwhile, type of original auto-immune disease, none classical EVAR were not significant related to MACE.Conclusions:Endovascular therapy is safe and effective for AIPA. Regular peri-operation and long-term immunotherapy is key to success.
authors.affiliation: Department of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing 100730, China.
authors.forename: W
authors.initials: W
authors.lastname: Ye
authors.forename: X
authors.initials: X
authors.lastname: Di
authors.forename: Q
authors.initials: Q
authors.lastname: Liu
authors.forename: Y J
authors.initials: YJ
authors.lastname: Li
authors.forename: Y H
authors.initials: YH
authors.lastname: Zheng
authors.forename: R
authors.initials: R
authors.lastname: Zeng
authors.forename: X J
authors.initials: XJ
authors.lastname: Song
authors.forename: Z L
authors.initials: ZL
authors.lastname: Liu
authors.forename: C W
authors.initials: CW
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D001012:Aorta, Abdominal; D017544:Aortic Aneurysm, Abdominal; D057510:Endovascular Procedures; D005260:Female; D006801:Humans; D007154:Immune System Diseases; D008297:Male; D008875:Middle Aged; D019651:Plastic Surgery Procedures; D012077:Renal Artery; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome; D055815:Young Adult