title: [HIV-1 resistance to antiretroviral drugs in pregnant women from Buenos Aires metropolitan area].
abstract: The study aimed to determine the prevalence of antiretroviral resistance associated mutations in HIV-1 infected pregnant woman treated in Buenos Aires metropolitan area (period 2008-2014). A total of 136 women with viral load = 500 copies/ml were included: 77 (56.6%) were treatment-naïve and 59 (43.4%) were antiretroviral-experienced patients either with current (n: 24) or previous (n = 35) antiretroviral therapy. Genotypic baseline resistance was investigated in plasma of antiretroviral-naïve patients and antiretroviral-experienced patients. The resistance mutations were identified according to the lists of the World Health Organization and the International Antiviral Society, respectively. Frequencies of resistance associated mutations detected in 2008-2011 and 2012-2014 were compared. A total of 37 (27.2%) women presented at least one resistance associated mutation: 25/94 (26.5%) in 2008-2011 and 12/42 (28.5%) in 2012-2014 (p > 0.05). Among naïves, 15 (19.5%) had at least one mutation: 10/49 (20.4%) in the period 2008-2011 and 5/28 (17.8%) in 2012-2014 (p > 0.05). The resistance mutations detected in naïves were associated with non nucleoside reverse transcriptase inhibitors, being K103N the most common mutation in both periods. In antiretroviral experienced patients, 22/59 (37.3%) had at least one resistance mutation. This study demonstrates a high frequency of resistance associated mutations which remained stable in the period analyzed. These levels suggest an increased circulation of HIV-1 antiretroviral resistant strains in our setting compared to previous reports from Argentina.
authors.affiliation: Unidad Virología, Hospital de Infecciosas Dr. F. J. Muñiz, Buenos Aires, Argentina. E-mail: izapiola@hotmail.com.
authors.forename: Inés
authors.initials: I
authors.lastname: Zapiola
authors.affiliation: Grupo de Trabajo en la Prevención de la Transmisión Vertical, Hospital Argerich, Buenos Aires, Argentina.
authors.forename: Diego
authors.initials: D
authors.lastname: Cecchini
authors.affiliation: Unidad Virología, Hospital de Infecciosas Dr. F. J. Muñiz, Buenos Aires, Argentina.
authors.forename: Silvina
authors.initials: S
authors.lastname: Fernández Giuliano
authors.affiliation: Grupo de Trabajo en la Prevención de la Transmisión Vertical, Hospital Argerich, Buenos Aires, Argentina.
authors.forename: Marina
authors.initials: M
authors.lastname: Martínez
authors.affiliation: Grupo de Trabajo en la Prevención de la Transmisión Vertical, Hospital Argerich, Buenos Aires, Argentina.
authors.forename: Claudia
authors.initials: C
authors.lastname: Rodríguez
authors.affiliation: Unidad Virología, Hospital de Infecciosas Dr. F. J. Muñiz, Buenos Aires, Argentina.
authors.forename: María Belén
authors.initials: MB
authors.lastname: Bouzas
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods; D001118:Argentina / Q000453:epidemiology; D024882:Drug Resistance, Viral / Q000187:drug effects* / Q000235:genetics; D005260:Female; D005838:Genotype; D005865:Gestational Age; D015658:HIV Infections / Q000188:drug therapy* / Q000453:epidemiology / Q000821:virology; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D009154:Mutation; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy* / Q000453:epidemiology / Q000821:virology; D013997:Time Factors; D019562:Viral Load; D055815:Young Adult
chemical_list: D019380:Anti-HIV Agents
keywords: HIV-1; antiretroviral therapy; mutation; pregnancy; vertical transmission