title: Lifestyle Risk Factors for Breast Cancer in BRCA1/2-Mutation Carriers Around Childbearing Age.
abstract: BRCA1/2-mutation carriers are at high risk of breast cancer (BC) and ovarian cancer. Physical inactivity, overweight (body mass index ≥25, BMI), smoking, and alcohol consumption are jointly responsible for about 1 in 4 postmenopausal BC cases in the general population. Limited evidence suggests physical activity also increases BC risk in BRCA1/2-mutation carriers. Women who have children often reduce physical activity and have weight gain, which increases BC risk. We assessed aforementioned lifestyle factors in a cohort of 268 BRCA1/2-mutation carriers around childbearing age (born between 1968 and 1983, median age 33 years, range 21-44). Furthermore, we evaluated the effect of having children on physical inactivity and overweight. Carriers were asked about lifestyle 4-6 weeks after genetic diagnosis at the Familial Cancer Clinic Nijmegen. Physical inactivity was defined as sports activity fewer than once a week. Carriers were categorized according to the age of their youngest child (no children, age 0-3 years and ≥4 years). In total, 48% of carriers were physically inactive, 41% were overweight, 27% smoked, and 70% consumed alcohol (3% ≥8 beverages/week). Physical inactivity was 4-5 times more likely in carriers with children. Overweight was not associated with having children. Carriers with children are a subgroup that may specifically benefit from lifestyle support to reduce BC risk.
authors.affiliation: Department of Human Genetics 836, Radboud University Medical Center, PO BOX 9101, 6500 HB, Nijmegen, The Netherlands.
authors.forename: A
authors.initials: A
authors.lastname: van Erkelens
authors.affiliation: Department of Human Genetics 836, Radboud University Medical Center, PO BOX 9101, 6500 HB, Nijmegen, The Netherlands.
authors.forename: L
authors.initials: L
authors.lastname: Derks
authors.affiliation: Department of Human Genetics 836, Radboud University Medical Center, PO BOX 9101, 6500 HB, Nijmegen, The Netherlands.
authors.forename: A S
authors.initials: AS
authors.lastname: Sie
authors.affiliation: Department of Human Genetics 836, Radboud University Medical Center, PO BOX 9101, 6500 HB, Nijmegen, The Netherlands.
authors.forename: L
authors.initials: L
authors.lastname: Egbers
authors.affiliation: Department of Human Genetics 836, Radboud University Medical Center, PO BOX 9101, 6500 HB, Nijmegen, The Netherlands.
authors.forename: G
authors.initials: G
authors.lastname: Woldringh
authors.affiliation: Department of Medical Psychology, Radboud University Medical Center, Nijmegen, the Netherlands.
authors.forename: J B
authors.initials: JB
authors.lastname: Prins
authors.affiliation: Department of Human Genetics 836, Radboud University Medical Center, PO BOX 9101, 6500 HB, Nijmegen, The Netherlands.
authors.forename: P
authors.initials: P
authors.lastname: Manders
authors.affiliation: Department of Human Genetics 836, Radboud University Medical Center, PO BOX 9101, 6500 HB, Nijmegen, The Netherlands. nicoline.hoogerbrugge@radboudumc.nl.
authors.forename: N
authors.initials: N
authors.lastname: Hoogerbrugge
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000209:etiology* / Q000235:genetics*; D015331:Cohort Studies; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D006579:Heterozygote; D006801:Humans; D008019:Life Style; D009035:Mothers; D009154:Mutation; D012307:Risk Factors; D055815:Young Adult
keywords: BRCA; Breast cancer; Children; Lifestyle; Overweight; Physical activity; Risk factor