title: Trajectories of quality of life, life satisfaction, and psychological adjustment after prostate cancer.
abstract: BACKGROUND
  To describe trajectories of health-related quality of life (QoL), life satisfaction, and psychological adjustment for men with prostate cancer over the medium to long term and identify predictors of poorer outcomes using growth mixture models.
  
  
  METHODS
  One-thousand sixty-four (82.4% response) men diagnosed with prostate cancer were recruited close to diagnosis and assessed over a 72-month (6-year) period with self-report assessment of health-related QoL, life satisfaction, cancer-related distress, and prostate specific antigen anxiety. Urinary, bowel, and sexual function were also assessed using validated questionnaires.
  
  
  RESULTS
  Poorer physical QOL was predicted by older age, lower education, lower income, comorbidities, and receiving hormone therapy. Lower life satisfaction was related to younger age, lower income, not being partnered, and comorbidities. Poorer psychological trajectories were predicted by younger age, lower income, comorbidities, and receiving radical prostatectomy or brachytherapy. Better urinary, bowel, and sexual function were related to better global outcomes over time. Anxiety about prostate specific antigen testing was rare.
  
  
  CONCLUSIONS
  Distinct trajectories exist for medium- to long-term QoL, life satisfaction, and psychological adjustment after prostate cancer; with age and socioeconomic deprivation playing a differential role in men's survivorship profile and the impact of functional status on outcomes increasing over time. These results reinforce the need for an appraisal of men's life course in addition to treatment side effects when planning survivorship care after cancer.
authors.affiliation: Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD, Australia.|Cancer Council Queensland, Brisbane, QLD, Australia.|Prostate Cancer Foundation of Australia, Sydney, NSW, Australia.|Exercise Medicine Research Institute, Edith Cowan University, Perth, WA, Australia.|Institute for Resilient Regions, University of Southern Queensland, Toowoomba, QLD, Australia.
authors.forename: Suzanne K
authors.initials: SK
authors.lastname: Chambers
authors.affiliation: Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD, Australia.
authors.forename: Shu Kay
authors.initials: SK
authors.lastname: Ng
authors.affiliation: Cancer Council Queensland, Brisbane, QLD, Australia.|School of Mathematical Sciences, Queensland University of Technology, Brisbane, QLD, Australia.|Menzies School of Health Research, Brisbane, QLD, Australia.
authors.forename: Peter
authors.initials: P
authors.lastname: Baade
authors.affiliation: Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD, Australia.|Cancer Council Queensland, Brisbane, QLD, Australia.|Institute for Resilient Regions, University of Southern Queensland, Toowoomba, QLD, Australia.|School of Public Health and Social Work, Queensland University of Technology, Brisbane, QLD, Australia.
authors.forename: Joanne F
authors.initials: JF
authors.lastname: Aitken
authors.affiliation: Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD, Australia.|Cancer Council Queensland, Brisbane, QLD, Australia.
authors.forename: Melissa K
authors.initials: MK
authors.lastname: Hyde
authors.affiliation: Freemasons Foundation Centre for Men's Health, School of Medicine, University of Adelaide, Adelaide, SA, Australia.
authors.forename: Gary
authors.initials: G
authors.lastname: Wittert
authors.affiliation: Department of Surgery, Faculty of Medicine, Monash University, Melbourne, VIC, Australia.|Department of Urology, Monash Health, Melbourne, VIC, Australia.
authors.forename: Mark
authors.initials: M
authors.lastname: Frydenberg
authors.affiliation: Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD, Australia.|Cancer Council Queensland, Brisbane, QLD, Australia.|Institute for Resilient Regions, University of Southern Queensland, Toowoomba, QLD, Australia.
authors.forename: Jeff
authors.initials: J
authors.lastname: Dunn
mesh_terms: D000223:Adaptation, Psychological; D000368:Aged; D000066498:Emotional Adjustment; D006801:Humans; D008297:Male; D008875:Middle Aged; D010549:Personal Satisfaction; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000523:psychology* / Q000628:therapy; D011788:Quality of Life / Q000523:psychology*; D011795:Surveys and Questionnaires
keywords: cancer; longitudinal; oncology; prostate; psychological distress; quality of life