title: Kinetic Resolution Driven Diastereo- and Enantioselective Synthesis of cis-β-Heteroaryl Amino Cycloalkanols by Ruthenium-Catalyzed Asymmetric Transfer Hydrogenation.
abstract: The utility of tethered Ru-TsDPEN catalyst has been demonstrated for the asymmetric transfer hydrogenation of rac-α-heteroaryl amino cycloalkanones to construct biologically important cis-β-heteroaryl amino cycloalkanols with two contiguous chiral centers via dynamic kinetic resolution. The stated (R,R)-Teth-TsDPEN-Ru-catalyzed transformation is carried out under mild conditions using formic acid/triethylamine as a hydrogen source with excellent diastereo- and enantioselectivities. Further, this methodology has been applied for the synthesis of an antileishmanial agent and chiral ionic liquid.
authors.affiliation: Department of Chemistry, Institute of Chemical Technology , Mumbai 400019, India.
authors.forename: Vijyesh K
authors.initials: VK
authors.lastname: Vyas
authors.affiliation: Department of Chemistry, Institute of Chemical Technology , Mumbai 400019, India.
authors.forename: Bhalchandra M
authors.identifier: 0000-0001-9538-3339
authors.initials: BM
authors.lastname: Bhanage