title: A Novel Link between Inflammation and Cancer.
abstract: Immune checkpoint-blockade treatments targeting PD-1/PD-L1 have revolutionized cancer therapy. Hence, understanding the regulation of PD-L1 expression has major clinical relevance. In this issue of Cancer Cell, Lim et al. report that inflammation-induced and NF-κB-driven expression of deubiquitinating enzyme CSN5 leads to PD-L1 stabilization and immune suppression in tumors.
authors.affiliation: Department of Microbiology & Immunology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
authors.forename: Yenkel
authors.initials: Y
authors.lastname: Grinberg-Bleyer
authors.affiliation: Department of Microbiology & Immunology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. Electronic address: sg2715@cumc.columbia.edu.
authors.forename: Sankar
authors.initials: S
authors.lastname: Ghosh
mesh_terms: D060890:B7-H1 Antigen / Q000378:metabolism*; D000075686:COP9 Signalosome Complex; D059447:Cell Cycle Checkpoints; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007113:Immunity, Innate; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism*; D016328:NF-kappa B / Q000378:metabolism; D009369:Neoplasms / Q000235:genetics / Q000276:immunology*; D010447:Peptide Hydrolases / Q000235:genetics / Q000378:metabolism*
chemical_list: D060890:B7-H1 Antigen; C423236:CD274 protein, human; D047908:Intracellular Signaling Peptides and Proteins; D016328:NF-kappa B; D010447:Peptide Hydrolases; C501488:COPS5 protein, human; D000075686:COP9 Signalosome Complex