title: Sodium fluoride does not affect the working memory and number of pyramidal cells in rat medial prefrontal cortex.
abstract: Fluoride is a chemical compound known to bring about fluorosis. It is thought to disrupt the central nervous system because of its ability to induce excitotoxicity and oxidative stress. Any damage of pyramidal cells in the prefrontal cortex would result in cognitive function and working memory regulation disorders. The present study aimed at investigating the effects of sodium fluoride (NaF) on the working memory and estimated total number of medial prefrontal cortex pyramidal cells of adult male rats. Thirty-two male Wistar rats were assigned into four groups, namely control and three treated groups receiving 5, 10 and 20 mg/kg BW, respectively, of oral NaF solution for 30 days. The working memory test was carried out using a Y-maze. The number of pyramidal cells in the medial prefrontal cortex was estimated using an unbiased stereological method. There was no significant difference among groups in the working memory and number of pyramidal neurons in the medial prefrontal cortex cells.
authors.affiliation: Department of Physiology, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, 55281, Indonesia.|Health Polytechnic Mamuju, West Sulawesi, Indonesia.
authors.forename: Zulhaini Sartika A
authors.initials: ZSA
authors.lastname: Pulungan
authors.affiliation: Department of Physiology, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, 55281, Indonesia.
authors.forename: Zaenal Muttaqien
authors.initials: ZM
authors.lastname: Sofro
authors.affiliation: Department of Physiology, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, 55281, Indonesia. gpartadiredja@yahoo.com.
authors.forename: Ginus
authors.identifier: http://orcid.org/0000-0003-0395-4240
authors.initials: G
authors.lastname: Partadiredja
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002452:Cell Count / Q000379:methods; D008297:Male; D008570:Memory, Short-Term / Q000187:drug effects*; D018384:Oxidative Stress / Q000187:drug effects; D017397:Prefrontal Cortex / Q000166:cytology* / Q000187:drug effects*; D017966:Pyramidal Cells / Q000187:drug effects*; D017208:Rats, Wistar; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000009:adverse effects* / Q000633:toxicity*
chemical_list: D012969:Sodium Fluoride
keywords: Prefrontal cortex; Pyramidal cells; Sodium fluoride; Stereology; Working memory