title: A Prospective Study Comparing Platelet-Rich Plasma and Local Anesthetic (LA)/Corticosteroid in Intra-Articular Injection for the Treatment of Lumbar Facet Joint Syndrome.
abstract: To compare the effectiveness and safety between autologous platelet-rich plasma (PRP) and Local Anesthetic (LA)/corticosteroid in intra-articular injection for the treatment of lumbar facet joint syndrome.
  
  
  
  Forty-six eligible patients with lumbar facet joint syndrome were randomized into group A (intra-articular injection with PRP) and group B (intra-articular injection with LA/corticosteroid). The following contents were evaluated: pain visual analog scale (VAS) at rest and during flexion, and the Roland-Morris Disability Questionnaire (RMQ), Oswestry Disability Index (ODI), and modified MacNab criteria for pain relief and applications of post-treatment drugs. All outcome assessments were performed immediately after and at 1 week, 1, 2, 3, and 6 months after treatment.
  
  
  
  No significant difference between groups was observed at baseline. Compared with pretreatment, both group A and group B demonstrated statistical improvements in the pain VAS score at rest or during flexion, the RMQ, and the ODI (P < 0.01). And there were significant differences between the 2 groups on the above-mentioned items (P < 0.05). For group B, subjective satisfaction based on the modified MacNab criteria and objective success rate were highest (80% and 85%) after 1 month, but only 50% and 20% after 6 months. However, for group A, they increased over time. In addition, there were no treatment-related complications in either group during follow-up.
  
  
  
  Both autologous PRP and LA/corticosteroid for intra-articular injection are effective, easy, and safe enough in the treatment of lumbar facet joint syndrome. However, autologous PRP is a superior treatment option for longer duration efficacy.
authors.affiliation: Department of Orthopaedics, The Second Hospital, Jilin University, Changchun, Jilin, China.
authors.forename: Jiuping
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Imaging and Nuclear Medicine, The Second Hospital, Jilin University, Changchun, Jilin, China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Department of Orthopaedics, The Second Hospital, Jilin University, Changchun, Jilin, China.
authors.forename: Chibing
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Orthopaedics, The Second Hospital, Jilin University, Changchun, Jilin, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Orthopaedics, The Second Hospital, Jilin University, Changchun, Jilin, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Xiong
authors.affiliation: Department of Orthopaedics, The Second Hospital, Jilin University, Changchun, Jilin, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Lv
authors.affiliation: Department of Orthopaedics, The Second Hospital, Jilin University, Changchun, Jilin, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Liu
authors.affiliation: Department of Orthopaedics, The Second Hospital, Jilin University, Changchun, Jilin, China.
authors.forename: Ruiqiang
authors.initials: R
authors.lastname: Wang
authors.affiliation: Department of Orthopaedics, The Second Hospital, Jilin University, Changchun, Jilin, China.
authors.forename: Zhenwu
authors.initials: Z
authors.lastname: Du
authors.affiliation: Department of Orthopaedics, The Second Hospital, Jilin University, Changchun, Jilin, China.
authors.forename: Guizhen
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Department of Orthopaedics, The Second Hospital, Jilin University, Changchun, Jilin, China.
authors.forename: Qinyi
authors.initials: Q
authors.lastname: Liu
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D000328:Adult; D000368:Aged; D000772:Anesthesia, Local / Q000379:methods; D000779:Anesthetics, Local / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007270:Injections, Intra-Articular; D017116:Low Back Pain / Q000000981:diagnostic imaging* / Q000628:therapy; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement / Q000379:methods; D053657:Platelet-Rich Plasma; D011446:Prospective Studies; D016059:Range of Motion, Articular / Q000187:drug effects; D013577:Syndrome; D016896:Treatment Outcome; D021801:Zygapophyseal Joint / Q000000981:diagnostic imaging*
chemical_list: D000305:Adrenal Cortex Hormones; D000779:Anesthetics, Local
keywords: LA/corticosteroid; intra-articular injection; low back pain; lumbar facet joint syndrome; platelet-rich plasma