title: Vocal emotion processing deficits in HIV-infected individuals.
abstract: We aimed to explore the brain imaging correlates of vocal emotion processing in a group of HIV+ individuals and to compare the vocal emotion processing of HIV+ individuals with a group of healthy adults. We conducted multiple linear regressions to determine the cerebral correlates of a newly designed vocal emotion processing test in a sub-group of HIV+ individuals who completed the cerebral magnetic resonance scan (n = 36). Separately, we test whether the association between our test scores and each cerebral measure persisted regardless of the presence of neurocognitive impairment. We also calculated differences in average test scores between the total HIV+ group (n = 100) and a healthy adult group (n = 46). We found a positive association between the test scores and several brain area volumes: right frontal, temporal and parietal lobes, bilateral thalamus, and left hippocampus. We found a negative association between inflammatory markers in frontal white matter and the test scores. After controlling by neurocognitive impairment, several brain area volumes remained positively associated to the prosody test scores. Moreover, the whole HIV+ sample had significantly poorer test scores than healthy adults, but only in the subset of HIV+ individuals with neurocognitive impairment. For the first time, our results suggest that cerebral dysfunctions in particular brain areas involved in the processing of emotional auditory stimuli may occur in HIV+ individuals. These results highlight the need for broad characterization of the neuropsychological consequence of HIV brain damages.
authors.affiliation: HIV Unit, Internal Medicine Service, Hospital Universitario La Paz, IdiPAZ, Paseo de la Castellana 261, 28046, Madrid, Spain. alicia.gonzalez@idipaz.es.|Biological and Health Psychology Department, Universidad Autónoma de Madrid, Campus de Cantoblanco, C/Iván Paulov 6, 28049, Madrid, Spain. alicia.gonzalez@idipaz.es.
authors.forename: A
authors.identifier: 0000-0002-2265-8976
authors.initials: A
authors.lastname: González-Baeza
authors.affiliation: HIV Unit, Internal Medicine Service, Hospital Universitario La Paz, IdiPAZ, Paseo de la Castellana 261, 28046, Madrid, Spain.
authors.forename: J R
authors.initials: JR
authors.lastname: Arribas
authors.affiliation: HIV Unit, Internal Medicine Service, Hospital Universitario La Paz, IdiPAZ, Paseo de la Castellana 261, 28046, Madrid, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Pérez-Valero
authors.affiliation: Health and Medical-Social Sciences Department, Universidad de Alcalá de Henares, Plaza de San Diego, s/n, 28801, Madrid, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Monge
authors.affiliation: Psychiatry Service, Hospital Universitario La Paz, IdiPAZ, Paseo de la Castellana 261, 28046, Madrid, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Bayón
authors.affiliation: Biological and Health Psychology Department, Universidad Autónoma de Madrid, Campus de Cantoblanco, C/Iván Paulov 6, 28049, Madrid, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Martín
authors.affiliation: Biological and Health Psychology Department, Universidad Autónoma de Madrid, Campus de Cantoblanco, C/Iván Paulov 6, 28049, Madrid, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Rubio
authors.affiliation: Biological and Health Psychology Department, Universidad Autónoma de Madrid, Campus de Cantoblanco, C/Iván Paulov 6, 28049, Madrid, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Carvajal
mesh_terms: D000328:Adult; D000342:Affective Symptoms / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000821:virology; D001307:Auditory Perception; D001931:Brain Mapping; D016022:Case-Control Studies; D060825:Cognitive Dysfunction / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000821:virology; D005260:Female; D005625:Frontal Lobe / Q000000981:diagnostic imaging / Q000473:pathology / Q000821:virology; D015658:HIV Infections / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000821:virology; D006624:Hippocampus / Q000000981:diagnostic imaging / Q000473:pathology / Q000821:virology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010296:Parietal Lobe / Q000000981:diagnostic imaging / Q000473:pathology / Q000821:virology; D013060:Speech; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000473:pathology / Q000821:virology; D013788:Thalamus / Q000000981:diagnostic imaging / Q000473:pathology / Q000821:virology; D066127:White Matter / Q000000981:diagnostic imaging / Q000473:pathology / Q000821:virology
keywords: Emotional prosody; HIV; Neurocognitive impairment; Vocal emotion processing