title: Predictive values of anti-müllerian hormone, antral follicle count and ovarian response prediction index (ORPI) for assisted reproductive technology outcomes.
abstract: This prospective study was performed from June 2012 to June 2014 at Royan Institute to compare the predictive values of serum anti-müllerian hormone (AMH), antral follicle count (AFC) and ovarian response prediction index (ORPI) ([AFC × AMH]/age) for in vitro fertilisation/intracytoplasmic sperm injection (IVF/ICSI) cycle outcomes. Five hundred and fifty women included in the study with male factor and unexplained infertility were the first candidates for IVF/ICSI cycles. Serum AMH level was measured by a commercial ELISA kit and AFC was calculated by a transvaginal ultrasonography on day 2-3 of the menstrual cycle before starting ovarian stimulation. All women underwent IVF/ICSI cycles using a long standard protocol with gonadotropin-releasing hormone agonist. The receiver operating characteristic curves (ROC) analysis showed that both AMH and AFC were good predictors of ovarian response with an area under the curves (AUC) > 0.75; even it seems that AFC was being a better predictor. Combining these variables is necessary as ORPI will not improve the prediction value. All the variables had poor predictive ability (AUC <0.60) for clinical pregnancy and live birth rates. Logistic regression analysis showed the AMH less than 0.4 ng/ml and quality of transferred embryos were significant predictors for clinical pregnancy rate.
authors.affiliation: a Department of Endocrinology and Female Infertility , Reproductive Biomedicine Research Centre, Royan Institute for Reproductive Biomedicine, ACECR , Tehran , Iran.|b Department of Obstetrics and Gynaecology, Faculty of Medicine , Iran University of Medical Science , Tehran , Iran.
authors.forename: Mahnaz
authors.initials: M
authors.lastname: Ashrafi
authors.affiliation: a Department of Endocrinology and Female Infertility , Reproductive Biomedicine Research Centre, Royan Institute for Reproductive Biomedicine, ACECR , Tehran , Iran.
authors.forename: Mandana
authors.initials: M
authors.lastname: Hemat
authors.affiliation: a Department of Endocrinology and Female Infertility , Reproductive Biomedicine Research Centre, Royan Institute for Reproductive Biomedicine, ACECR , Tehran , Iran.
authors.forename: Arezoo
authors.initials: A
authors.lastname: Arabipoor
authors.affiliation: c Department of Andrology , Reproductive Biomedicine Research Centre, Royan Institute for Reproductive Biomedicine, ACECR , Tehran , Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Salman Yazdi
authors.affiliation: a Department of Endocrinology and Female Infertility , Reproductive Biomedicine Research Centre, Royan Institute for Reproductive Biomedicine, ACECR , Tehran , Iran.
authors.forename: Akram
authors.initials: A
authors.lastname: Bahman-Abadi
authors.affiliation: d Department of Epidemiology and Reproductive Health, Reproductive Epidemiology Research Centre , Royan Institute for Reproductive Biomedicine, ACECR , Tehran , Iran.
authors.forename: Rezvaneh
authors.initials: R
authors.lastname: Cheraghi
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods / Q000706:statistics & numerical data*; D006801:Humans; D007246:Infertility / Q000097:blood / Q000601:surgery; D008297:Male; D006080:Ovarian Follicle; D010062:Ovulation Induction / Q000379:methods; D011237:Predictive Value of Tests; D011247:Pregnancy; D018873:Pregnancy Rate; D011446:Prospective Studies; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods / Q000706:statistics & numerical data*; D016896:Treatment Outcome
chemical_list: D054304:Anti-Mullerian Hormone
keywords: Anti-müllerian hormone; antral follicle count; live birth rate; ovarian response prediction index