title: Osteoporosis: advances in risk assessment and management.
abstract: In the past three decades, there have been major advances in our understanding of bone biology and these have been -accompanied by a significant improvement in the management of osteoporosis. Fracture risk prediction algorithms using -clinical risk factors, with or without measurement of bone mineral density, have enabled more accurate targeting of treatment and a range of cost-effective pharmacological interventions is available to reduce fracture risk. Despite these advances, a number of challenges remain. In particular, treatment rates in high-risk individuals are low and adherence to treatment is poor. Addressing this treatment gap through measures such as fracture liaison services, which provide a coordinated and cost-effective strategy for secondary fracture prevention, is an important future priority.
authors.affiliation: Cambridge Biomedical Campus, Cambridge, UK jec1001@cam.ac.uk.
authors.forename: Juliet
authors.initials: J
authors.lastname: Compston
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015519:Bone Density; D004164:Diphosphonates; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000453:epidemiology / Q000628:therapy; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D004164:Diphosphonates
keywords: Bisphosphonates; FRAX; bone density; fracture; osteoporosis; risk factors