title: Neonatal Metabolomic Profiles Related to Prenatal Arsenic Exposure.
abstract: Prenatal inorganic arsenic (iAs) exposure is associated with health effects evident at birth and later in life. An understanding of the relationship between prenatal iAs exposure and alterations in the neonatal metabolome could reveal critical molecular modifications, potentially underpinning disease etiologies. In this study, nuclear magnetic resonance (NMR) spectroscopy-based metabolomic analysis was used to identify metabolites in neonate cord serum associated with prenatal iAs exposure in participants from the Biomarkers of Exposure to ARsenic (BEAR) pregnancy cohort, in Gómez Palacio, Mexico. Through multivariable linear regression, ten cord serum metabolites were identified as significantly associated with total urinary iAs and/or iAs metabolites, measured as %iAs, %monomethylated arsenicals (MMAs), and %dimethylated arsenicals (DMAs). A total of 17 metabolites were identified as significantly associated with total iAs and/or iAs metabolites in cord serum. These metabolites are indicative of changes in important biochemical pathways such as vitamin metabolism, the citric acid (TCA) cycle, and amino acid metabolism. These data highlight that maternal biotransformation of iAs and neonatal levels of iAs and its metabolites are associated with differences in neonate cord metabolomic profiles. The results demonstrate the potential utility of metabolites as biomarkers/indicators of in utero environmental exposure.
authors.forename: Jessica E
authors.initials: JE
authors.lastname: Laine
authors.forename: Kathryn A
authors.initials: KA
authors.lastname: Bailey
authors.forename: Andrew F
authors.initials: AF
authors.lastname: Olshan
authors.forename: Lisa
authors.initials: L
authors.lastname: Smeester
authors.affiliation: Department of Biological Sciences, College of Sciences, North Carolina State University , Raleigh, North Carolina 27695, United States.
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Drobná
authors.forename: Miroslav
authors.initials: M
authors.lastname: Stýblo
authors.forename: Christelle
authors.initials: C
authors.lastname: Douillet
authors.affiliation: Facultad de Medicina, Universidad Juarez del Estado de Durango , Gómez Palacio, Durango 35050, Mexico.
authors.forename: Gonzalo
authors.initials: G
authors.lastname: García-Vargas
authors.affiliation: Facultad de Medicina, Universidad Juarez del Estado de Durango , Gómez Palacio, Durango 35050, Mexico.
authors.forename: Marisela
authors.initials: M
authors.lastname: Rubio-Andrade
authors.affiliation: RTI International, Research Triangle Park, North Carolina 27709, United States.
authors.forename: Wimal
authors.initials: W
authors.lastname: Pathmasiri
authors.affiliation: RTI International, Research Triangle Park, North Carolina 27709, United States.
authors.forename: Susan
authors.initials: S
authors.lastname: McRitchie
authors.affiliation: RTI International, Research Triangle Park, North Carolina 27709, United States.
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Sumner
authors.forename: Rebecca C
authors.identifier: 0000-0003-0899-9018
authors.initials: RC
authors.lastname: Fry
mesh_terms: D001151:Arsenic; D001152:Arsenicals; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D055432:Metabolomics; D008800:Mexico; D011247:Pregnancy
chemical_list: D001152:Arsenicals; D001151:Arsenic