title: Primary hyperparathyroidism in pregnancy treated with cinacalcet: a case report and review of the literature.
abstract: BACKGROUND
  The efficacy and safety of various modes of medical treatment for primary hyperparathyroidism in pregnancy are largely unknown.
  
  
  METHODS
  We report the case of a 34-year-old white woman with primary hyperparathyroidism symptomatic for nephrolithiasis. Her serum calcium was 3.15 mmol/l and parathyroid hormone was 109.0 ng/L. Neck imaging found no pathological parathyroid tissue. Cinacalcet and cholecalciferol were started. She became pregnant 17 months later. The calcimimetic was stopped. During pregnancy, she was admitted for hydration administered intravenously two to three times per week. In her 24thweek of pregnancy, cinacalcet was restarted. In her 32nd week, a cesarean section was carried out as planned.
  
  
  CONCLUSIONS
  Only three cases of primary hyperparathyroidism in women on cinacalcet therapy in pregnancy have been published in the literature. In the present case, hydration was useful in controlling serum calcium. Cinacalcet therapy helped to control serum calcium.
authors.affiliation: Department of Internal Medicine, Genoa University, Viale Benedetto XV 6, 16132, Genoa, Italy.
authors.forename: Lara
authors.initials: L
authors.lastname: Vera
authors.affiliation: Department of Internal Medicine, Genoa University, Viale Benedetto XV 6, 16132, Genoa, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Oddo
authors.affiliation: Department of Pediatrics, IRCC G. Gaslini, Genoa, Italy.
authors.forename: Natascia
authors.initials: N
authors.lastname: Di Iorgi
authors.affiliation: Department of Obstetrics and Gynecology, IRCC G. Gaslini, Genoa, Italy.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Bentivoglio
authors.affiliation: Department of Internal Medicine, Genoa University, Viale Benedetto XV 6, 16132, Genoa, Italy. magius@unige.it.
authors.forename: Massimo
authors.initials: M
authors.lastname: Giusti
mesh_terms: D000328:Adult; D057966:Calcimimetic Agents / Q000627:therapeutic use*; D002585:Cesarean Section; D000069449:Cinacalcet / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D049950:Hyperparathyroidism, Primary / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D055103:Hypodermoclysis / Q000379:methods*; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D057966:Calcimimetic Agents; D000069449:Cinacalcet
keywords: Calcimimetic; Case report; Cinacalcet; Hypercalcemia; Pregnancy; Primary hyperparathyroidism