title: Stilbene Derivatives from Photorhabdus temperata SN259 and Their Antifungal Activities against Phytopathogenic Fungi.
abstract: Chemical investigation of an insect pathogenic enterobacterium, Photorhabdus temperata SN259, led to the isolation and identification of seven metabolites, which include three new compounds, 3-hydroxy-2-isopropyl-5-phenethylphenyl carbamate, 1, 2-(1-hydroxypropan-2-yl)-5-[2-phenylethyl]benzene-1,3-diol, 2, 2-(1-hydroxypropan-2-yl)-5-[(E)-2-phenylethenyl]benzene-1,3-diol, 3, and four known metabolites (4-7). Their structures were elucidated on the basis of MS and NMR data and by comparison with those reported previously. The activities of compounds 1-7 were evaluated against four phytopathogenic fungi (Pythium aphanidermatum, Rhizoctonia solani Kuhn, Exserohilum turcicum, and Fusarium oxysporum). In an agar medium assay, compounds 1 and 7 showed strong inhibition against P.  aphanidermatum with EC50values of 2.8 and 2.7 μg/mL, respectively. By comparing the structure of compounds 1-7, we deduced that the acylamino group in compound 1 and the isopropyl group in compound 7 contribute to the inhibitory activity.
authors.affiliation: College of Plant Protection, Shenyang Agricultural University , Shenyang 110866, People's Republic of China.
authors.forename: Danshu
authors.initials: D
authors.lastname: Shi
authors.affiliation: College of Plant Protection, Shenyang Agricultural University , Shenyang 110866, People's Republic of China.
authors.forename: Ran
authors.initials: R
authors.lastname: An
authors.affiliation: College of Plant Protection, Shenyang Agricultural University , Shenyang 110866, People's Republic of China.
authors.forename: Wenbo
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Agro-Environmental Protection Institute, Ministry of Agriculture , Tianjin 300191, People's Republic of China.
authors.forename: Guilong
authors.initials: G
authors.lastname: Zhang
authors.affiliation: College of Plant Protection, Shenyang Agricultural University , Shenyang 110866, People's Republic of China.|Engineering & Technological Research Center of Biopesticide for Liaoning Province , Shenyang 110866, People's Republic of China.
authors.forename: Zhiguo
authors.identifier: http://orcid.org/0000-0002-0909-6788
authors.initials: Z
authors.lastname: Yu
mesh_terms: D005659:Fungicides, Industrial / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D005670:Fusarium / Q000187:drug effects / Q000254:growth & development; D015394:Molecular Structure; D020637:Photorhabdus / Q000737:chemistry* / Q000378:metabolism; D010935:Plant Diseases / Q000382:microbiology*; D012232:Rhizoctonia / Q000187:drug effects / Q000254:growth & development; D013267:Stilbenes / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D005659:Fungicides, Industrial; D013267:Stilbenes
keywords: Exserohilum turcicum; Fusarium oxysporum; Photorhabdus temperata SN259; Pythium aphanidermatum; Rhizoctonia solani Kuhn; antifungal activity; stilbene derivatives