title: Cytoglobosins H and I, New Antiproliferative Cytochalasans from Deep-Sea-Derived Fungus Chaetomium globosum.
abstract: Cytoglobosins H (1) and I (2), together with seven known cytochalasan alkaloids (3-9), were isolated from the deep-sea-derived fungusChaetomium globosum. The structures of new compounds1and2were elucidated by extensive 1D and 2D NMR and mass spectroscopic data. All the compounds were evaluated for their antiproliferative activities against MDA-MB-231 human breast cancer cells, LNCaP human prostate cancer cells, and B16F10 mouse melanoma cells. Compound6showed significant antiproliferative activity against LNCaP and B16F10 cell lines with IC50values of 0.62 and 2.78 μM, respectively. Further testing confirmed that compound6inhibited the growth of LNCaP cells by inducing apoptosis.
authors.affiliation: Integrative Microbiology Research Centre, College of Agriculture, South China Agricultural University, Guangzhou 510642, China. zhihanzhang1992@163.com.
authors.forename: Zhihan
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Integrative Microbiology Research Centre, College of Agriculture, South China Agricultural University, Guangzhou 510642, China. mixmix@stu.scau.edu.cn.
authors.forename: Xitian
authors.initials: X
authors.lastname: Min
authors.affiliation: Pharmaceutical Research Center, School of Pharmacology, Guangzhou Medical University, Guangzhou 510182, China. huangjunjun1985@sina.com.
authors.forename: Junjun
authors.initials: J
authors.lastname: Huang
authors.affiliation: Integrative Microbiology Research Centre, College of Agriculture, South China Agricultural University, Guangzhou 510642, China. sloe96824400@126.com.
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhong
authors.affiliation: Integrative Microbiology Research Centre, College of Agriculture, South China Agricultural University, Guangzhou 510642, China. wuyuehua_10@163.com.
authors.forename: Yuehua
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Integrative Microbiology Research Centre, College of Agriculture, South China Agricultural University, Guangzhou 510642, China. m18320728922@163.com.
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Li
authors.affiliation: Integrative Microbiology Research Centre, College of Agriculture, South China Agricultural University, Guangzhou 510642, China. ydeng@scau.edu.cn.|Guangdong Innovative and Entrepreneurial Research Team of Sociomicrobiology Basic Science and Frontier Technology, South China Agricultural University, Guangzhou 510642, China. ydeng@scau.edu.cn.
authors.forename: Yinyue
authors.initials: Y
authors.lastname: Deng
authors.affiliation: Integrative Microbiology Research Centre, College of Agriculture, South China Agricultural University, Guangzhou 510642, China. zdjiang@scau.edu.cn.
authors.forename: Zide
authors.initials: Z
authors.lastname: Jiang
authors.affiliation: State Key Laboratory Breeding Base of Marine Genetic Resources, Third Institute of Oceanography, State Oceanic Administration, Key Laboratory of Marine Genetic Resources of Fujian Province, Xiamen 361005, China. shaozz@163.com.
authors.forename: Zongze
authors.initials: Z
authors.lastname: Shao
authors.affiliation: Integrative Microbiology Research Centre, College of Agriculture, South China Agricultural University, Guangzhou 510642, China. lhzhang01@scau.edu.cn.
authors.forename: Lianhui
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Integrative Microbiology Research Centre, College of Agriculture, South China Agricultural University, Guangzhou 510642, China. hefei@scsio.ac.cn.
authors.forename: Fei
authors.initials: F
authors.lastname: He
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002597:Chaetomium / Q000737:chemistry* / Q000302:isolation & purification; D002851:Chromatography, High Pressure Liquid; D004354:Drug Screening Assays, Antitumor; D005285:Fermentation; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D052616:Solid Phase Extraction
chemical_list: D000970:Antineoplastic Agents; D026121:Indole Alkaloids
keywords: antiproliferative activity; cytochalasans; fungus