title: Laser-enhanced high-intensity focused ultrasound heating in anin vivosmall animal model.
abstract: The enhanced heating effect during the combination of high-intensity focused ultrasound (HIFU) and low-optical-fluence laser illumination was investigated by using anin vivomurine animal model. The thighs of murine animals were synergistically irradiated by HIFU and pulsed nano-second laser light. The temperature increases in the target region were measured by a thermocouple under different HIFU pressures, which were 6.2, 7.9, and 9.8 MPa, in combination with 20 mJ/cm2laser exposures at 532 nm wavelength. In comparison with conventional laser therapies, the laser fluence used here is at least one order of magnitude lower. The results showed that laser illumination could enhance temperature during HIFU applications. Additionally, cavitation activity was enhanced when laser and HIFU irradiation were concurrently used. Further, a theoretical simulation showed that the inertial cavitation threshold was indeed decreased when laser and HIFU irradiation were utilized concurrently.
authors.affiliation: KU Bioengineering Research Center and Department of Mechanical Engineering, University of Kansas , 1530 W. 15th Street, 5109 Learned Hall, Lawrence, Kansas 66045, USA.
authors.forename: Janggun
authors.initials: J
authors.lastname: Jo
authors.affiliation: KU Bioengineering Research Center and Department of Mechanical Engineering, University of Kansas , 1530 W. 15th Street, 5109 Learned Hall, Lawrence, Kansas 66045, USA.
authors.forename: Xinmai
authors.initials: X
authors.lastname: Yang