title: Various Sequence Types of Escherichia coli Isolates CoharboringblaNDM-5andmcr-1Genes from a Commercial Swine Farm in China.
abstract: Sixteen different sequence types (STs) ofEscherichia coliisolates from a commercial swine farm in China were confirmed to coharbor the carbapenem resistance geneblaNDM-5and the colistin resistance genemcr-1Whole-genome sequencing revealed thatblaNDM-5andmcr-1were located on a 46-kb IncX3 plasmid and a 32-kb IncX4 plasmid, respectively. The two plasmids can transfer together with a low fitness cost, which might explain the presence of various STs ofE. colicoharboringblaNDM-5andmcr-1.
authors.affiliation: College of Life Science, Sichuan University, Chengdu, People's Republic of China.|Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, Chengdu, People's Republic of China.|Key Laboratory of Bio-resources and Eco-environment, Ministry of Education, Chengdu, People's Republic of China.
authors.forename: Ling-Han
authors.initials: LH
authors.lastname: Kong
authors.affiliation: College of Life Science, Sichuan University, Chengdu, People's Republic of China.|Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, Chengdu, People's Republic of China.|Key Laboratory of Bio-resources and Eco-environment, Ministry of Education, Chengdu, People's Republic of China.
authors.forename: Chang-Wei
authors.initials: CW
authors.lastname: Lei
authors.affiliation: College of Life Science, Sichuan University, Chengdu, People's Republic of China.|Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, Chengdu, People's Republic of China.|Key Laboratory of Bio-resources and Eco-environment, Ministry of Education, Chengdu, People's Republic of China.
authors.forename: Su-Zhen
authors.initials: SZ
authors.lastname: Ma
authors.affiliation: College of Life Science, Sichuan University, Chengdu, People's Republic of China.|Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, Chengdu, People's Republic of China.|Key Laboratory of Bio-resources and Eco-environment, Ministry of Education, Chengdu, People's Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: Jiang
authors.affiliation: College of Life Science, Sichuan University, Chengdu, People's Republic of China.|Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, Chengdu, People's Republic of China.|Key Laboratory of Bio-resources and Eco-environment, Ministry of Education, Chengdu, People's Republic of China.
authors.forename: Bi-Hui
authors.initials: BH
authors.lastname: Liu
authors.affiliation: College of Life Science, Sichuan University, Chengdu, People's Republic of China.|Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, Chengdu, People's Republic of China.|Key Laboratory of Bio-resources and Eco-environment, Ministry of Education, Chengdu, People's Republic of China.
authors.forename: Yong-Xiang
authors.initials: YX
authors.lastname: Wang
authors.affiliation: College of Life Science, Sichuan University, Chengdu, People's Republic of China.|Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, Chengdu, People's Republic of China.|Key Laboratory of Bio-resources and Eco-environment, Ministry of Education, Chengdu, People's Republic of China.
authors.forename: Ru
authors.initials: R
authors.lastname: Guan
authors.affiliation: College of Life Science, Sichuan University, Chengdu, People's Republic of China.|Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, Chengdu, People's Republic of China.|Key Laboratory of Bio-resources and Eco-environment, Ministry of Education, Chengdu, People's Republic of China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Men
authors.affiliation: College of Life Science, Sichuan University, Chengdu, People's Republic of China.|Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, Chengdu, People's Republic of China.|Key Laboratory of Bio-resources and Eco-environment, Ministry of Education, Chengdu, People's Republic of China.
authors.forename: Qi-Wu
authors.initials: QW
authors.lastname: Yuan
authors.affiliation: College of Life Science, Sichuan University, Chengdu, People's Republic of China.|Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, Chengdu, People's Republic of China.|Key Laboratory of Bio-resources and Eco-environment, Ministry of Education, Chengdu, People's Republic of China.
authors.forename: Guang-Yang
authors.initials: GY
authors.lastname: Cheng
authors.affiliation: College of Life Science, Sichuan University, Chengdu, People's Republic of China.|Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, Chengdu, People's Republic of China.|Key Laboratory of Bio-resources and Eco-environment, Ministry of Education, Chengdu, People's Republic of China.
authors.forename: Wen-Cheng
authors.initials: WC
authors.lastname: Zhou
authors.affiliation: College of Life Science, Sichuan University, Chengdu, People's Republic of China whongning@163.com.|Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, Chengdu, People's Republic of China.|Key Laboratory of Bio-resources and Eco-environment, Ministry of Education, Chengdu, People's Republic of China.|985 Project Science Innovative Platform for Resource and Environment Protection of Southwestern China, Chengdu, People's Republic of China.
authors.forename: Hong-Ning
authors.initials: HN
authors.lastname: Wang
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D015780:Carbapenems / Q000494:pharmacology; D002681:China / Q000453:epidemiology; D003091:Colistin / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics* / Q000254:growth & development / Q000302:isolation & purification; D004927:Escherichia coli Infections / Q000453:epidemiology / Q000382:microbiology / Q000662:veterinary*; D029968:Escherichia coli Proteins / Q000235:genetics* / Q000378:metabolism; D015870:Gene Expression; D022761:Gene Transfer, Horizontal; D056084:Genetic Fitness; D005838:Genotype; D010957:Plasmids / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D013552:Swine; D013553:Swine Diseases / Q000453:epidemiology* / Q000382:microbiology; D001618:beta-Lactamases / Q000235:genetics* / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D029968:Escherichia coli Proteins; C000614037:MCR-1 protein, E coli; D001618:beta-Lactamases; D003091:Colistin
keywords: Escherichia coli; blaNDM-5; carbapenems; colistin; fitness cost; mcr-1