title: Efficacy of triple association methotrexate, sulfasalazine and hydroxychloroquine in early treatment of rheumatoid arthritis with insufficient response to methotrexate: Meta-analysis of randomized controlled trials.
abstract: OBJECTIVE
  To evaluate the efficacy of the triple synthetic Disease Modifying Anti-Rheumatic Drugs (sDMARD) combination methotrexate, sulfasalazine and hydroxychloroquine versus a biologic DMARD (bDMARD) in the treatment of early rheumatoid arthritis.
  
  
  METHODS
  A systematic literature search was performed using the PubMed and Cochrane databases, and abstracts presented at rheumatology scientific meetings until December 2013. Randomized controlled trials comparing the efficacy and the safety of biologic DMARD with the triple combination were included. Outcome measures were Van der Heijde modified Sharp score (SHS), remission rate, ACR criteria response, adverse events.
  
  
  RESULTS
  A total of 1225 abstracts were screened. We extracted data from 5 trials including patients (515 in the triple combination group and 710 in the bDMARD group). We showed higher ACR70 response (OR=1.79, 95% CI [1.17, 2.72]) in patients treated with bDMARDs, whereas radiological progression was not different from patient with triple combination (OR=1.10, 95% CI [-0.04, 0.28]). At year 2, ACR70 response and remission rate, the results were similar in both groups with respectively OR=1.44 (95% CI [0.86, 2.43]) and SMD=0.45 (95% CI [0.17, 0.72]). The proportion of serious adverse events was similar in both groups OR=1.02 (95% CI [0.68, 1.52], P=0.92, I2=0%). Gastro-intestinal adverse events were higher in the triple combination group (OR=1.75, 95% CI [0.73, 4.21], P=0.21, I2=75%). Infectious adverse events were more frequent in the bDMARD group (OR=0.50, 95% CI [0.35, 0.70], P<0.0001, I2=36%).
  
  
  CONCLUSIONS
  Biological treatment seems to be more efficient than triple combination in terms of radiological progression in RA with inadequate response to methotrexate.
authors.affiliation: Rheumatology Department, Centre Hospitalier Alpes Léman, 74130 Contamine Sur Arve, France.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Mazouyès
authors.affiliation: Hôpital Sud, CHUGA, 38130 Echirolles, France.
authors.forename: Marine
authors.initials: M
authors.lastname: Clay
authors.affiliation: Hôpital Sud, CHUGA, 38130 Echirolles, France.
authors.forename: Anne-Catherine
authors.initials: AC
authors.lastname: Bernard
authors.affiliation: Hôpital Sud, CHUGA, 38130 Echirolles, France; GREPI-UGA EA7408, 38434 Echirolles, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Gaudin
authors.affiliation: Hôpital Sud, CHUGA, 38130 Echirolles, France; GREPI-UGA EA7408, 38434 Echirolles, France. Electronic address: abaillet@chu-grenoble.fr.
authors.forename: Athan
authors.initials: A
authors.lastname: Baillet
mesh_terms: D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000175:diagnosis / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006886:Hydroxychloroquine / Q000008:administration & dosage*; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D010147:Pain Measurement; D016032:Randomized Controlled Trials as Topic; D018570:Risk Assessment; D012720:Severity of Illness Index; D012460:Sulfasalazine / Q000008:administration & dosage*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D018501:Antirheumatic Agents; D012460:Sulfasalazine; D006886:Hydroxychloroquine; D008727:Methotrexate
keywords: Methotrexate; Rheumatoid arthritis; bDMARD