title: Structural and Functional Correlates of Myocardial T1 Mapping in 321 Patients With Hypertrophic Cardiomyopathy.
abstract: OBJECTIVE
  The aim of this study was to evaluate the structural and functional correlates of T1 mapping in 321 patients with hypertrophic cardiomyopathy (HCM).
  
  
  METHODS
  Three hundred twenty-one patients with HCM who underwent cardiac magnetic resonance from 2003 to 2013 were retrospectively identified from our institution's HCM registry. Left ventricular volume, function, late gadolinium enhancement (LGE), and Look-Locker T1 time were quantified. T1 time was normalized to blood pool to calculate T1 ratio. Correlations between LGE%, T1 ratio, and structural and functional features were performed using Pearson correlation coefficient.
  
  
  RESULTS
  Late gadolinium enhancement showed stronger correlation with left ventricular mass index (r = 0.41, P < 0.001) compared with T1 ratio (r = -0.17, P = 0.004). Both LGE% and T1 ratio correlated with ejection fraction (r = -0.18 and P = 0.002 vs r = 0.21 and P < 0.001, respectively). E/e' showed correlation with LGE% but not with T1 ratio.
  
  
  CONCLUSIONS
  Late gadolinium enhancement was more strongly correlated with the phenotypic expression of HCM compared with T1 ratio.
authors.affiliation: From the *Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine and Departments of †Pathology and ‡Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD; §Division of Image Processing, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands; and ∥Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD.
authors.forename: Linda C
authors.initials: LC
authors.lastname: Chu
authors.forename: Celia P
authors.initials: CP
authors.lastname: Corona-Villalobos
authors.forename: Marc K
authors.initials: MK
authors.lastname: Halushka
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Chiara
authors.initials: C
authors.lastname: Pozzessere
authors.forename: Ihab R
authors.initials: IR
authors.lastname: Kamel
authors.forename: Iraklis
authors.initials: I
authors.lastname: Pozios
authors.forename: Rob J
authors.initials: RJ
authors.lastname: Van Der Geest
authors.forename: Neville
authors.initials: N
authors.lastname: Gai
authors.forename: Roselle M
authors.initials: RM
authors.lastname: Abraham
authors.forename: Theodore P
authors.initials: TP
authors.lastname: Abraham
authors.forename: David A
authors.initials: DA
authors.lastname: Bluemke
authors.forename: Stefan L
authors.initials: SL
authors.lastname: Zimmerman
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002312:Cardiomyopathy, Hypertrophic / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D002648:Child; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006321:Heart / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D007089:Image Enhancement; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA