title: β-arrestin 2 attenuates cardiac dysfunction in polymicrobial sepsis through gp130 and p38.
abstract: Sepsis is an exaggerated systemic inflammatory response to persistent bacteria infection with high morbidity and mortality rate clinically. β-arrestin 2 modulates cell survival and cell death in different systems. However, the effect of β-arrestin 2 on sepsis-induced cardiac dysfunction is not yet known. Here, we show that β-arrestin 2 overexpression significantly enhances animal survival following cecal ligation and puncture (CLP)-induced sepsis. Importantly, overexpression of β-arrestin 2 in mice prevents CLP-induced cardiac dysfunction. Also, β-arrestin 2 overexpression dramatically attenuates CLP-induced myocardial gp130 and p38 mitogen-activated protein kinase (MAPK) phosphorylation levels following CLP. Therefore, β-arrestin 2 prevents CLP-induced cardiac dysfunction through gp130 and p38. These results suggest that modulation of β-arrestin 2 might provide a novel therapeutic approach to prevent cardiac dysfunction in patients with sepsis.
authors.affiliation: Department of Internal Medicine, College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA.
authors.forename: Hui
authors.initials: H
authors.lastname: Yan
authors.affiliation: Department of Internal Medicine, College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA.
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Internal Medicine, College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA.
authors.forename: James
authors.initials: J
authors.lastname: Denney
authors.affiliation: Department of Biomedical Sciences, College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Daniels
authors.affiliation: Department of Biomedical Sciences, College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA.
authors.forename: Krishna
authors.initials: K
authors.lastname: Singh
authors.affiliation: Cecile Cox Quillen Laboratory of Geriatrics, College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA.
authors.forename: Balvin
authors.initials: B
authors.lastname: Chua
authors.affiliation: Department of Internal Medicine, College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA.
authors.forename: Charles
authors.initials: C
authors.lastname: Stuart
authors.affiliation: Department of Internal Medicine, College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA.
authors.forename: Yi
authors.initials: Y
authors.lastname: Caudle
authors.affiliation: Cecile Cox Quillen Laboratory of Geriatrics, College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA.
authors.forename: Ronald
authors.initials: R
authors.lastname: Hamdy
authors.affiliation: Department of Internal Medicine, College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA.
authors.forename: Gene
authors.initials: G
authors.lastname: LeSage
authors.affiliation: Department of Internal Medicine, College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA.
authors.forename: Deling
authors.initials: D
authors.lastname: Yin
keywords: Cardiac function; Gp130; P38; Sepsis; β-arrestin 2