title: [Clinical significance of FOXM1 and Gli-1 protein expression in high-grade ovarian serous carcinoma].
abstract: Objective:To investigate the different expression and prognostic significance of forkhead box M1 (FOXM1) and Gli-l in ovarian high grade serous carcinoma (HGSC).Methods:The expressions of FOXM1 and Gli-1 in 94 cases of HGSC and 20 cases of normal fallopian tube tissues were detected by immunohistochemistry. Kaplan-Meier analysis and Cox multivariate survival analysis were used to assess the relationship of the FOXM1 and Gli-1 levels with age, International Federation of Gynecology and Obstetrics (FIGO) stage, omental metastasis, and residual foci and prognosis of HGSC.Results:The positive rates of FOXM1 and Gli-1 expression in HGSC were 79.8% (75/94) and 77.7% (73/94), respectively, both significantly higher than those of the normal controls (P<0.05). The expressions of FOXM1 and Gli-1 were significantly correlated with FIGO stage, and both of their positive rates in stage Ⅲ-Ⅳpatients were significantly higher than those in stage Ⅰ-Ⅱ cases (P<0.001). The expressions of FOXM1 in HGSC were positively correlated with Gli-1.Kaplan-Meier analysis revealed that the 5-year overall survival rates of FOXM1- and Gli-1-positive groups were 8.0% and 6.8%, significantly lower than 36.8% and 38.1% of the FOXM1- and Gli-1-negative groups, respectively (P<0.05 for both). Cox multivariate survival analysis revealed that FIGO stage and overexpression of FOXM1 protein were independent prognostic factors of HGSC patients (P<0.05 for both).Conclusions:The overexpression of FOXM1 and Gli-1 proteins participate in the carcinogenesis of HGSC, and are significantly associated with FIGO stage. The protein expression of FOXM1 is positively correlated with Gli-1 in HGSC. Expression of FOXM1 protein and FIGO stage are independent prognostic factors of HGSC.
authors.affiliation: Department of Gynecology, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China.
authors.forename: J
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Gynecology, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China.
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Li
authors.affiliation: Medical Record Department, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China.
authors.forename: X J
authors.initials: XJ
authors.lastname: Duan
authors.affiliation: Department of Gynecology, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China.
authors.forename: X M
authors.initials: XM
authors.lastname: Fan
authors.affiliation: Department of Pathology, Second Hospital of Hebei Medical University, Shijiazhuang 050000, China.
authors.forename: W N
authors.initials: WN
authors.lastname: Liu
authors.affiliation: Department of Pathology, Second Hospital of Hebei Medical University, Shijiazhuang 050000, China.
authors.forename: Y H
authors.initials: YH
authors.lastname: Li
mesh_terms: D000367:Age Factors; D018284:Cystadenocarcinoma, Serous / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D005260:Female; D000072278:Forkhead Box Protein M1 / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D009363:Neoplasm Proteins / Q000378:metabolism*; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D011379:Prognosis; D016019:Survival Analysis; D015996:Survival Rate; D013997:Time Factors; D000071676:Zinc Finger Protein GLI1 / Q000378:metabolism*
chemical_list: C107585:FOXM1 protein, human; D000072278:Forkhead Box Protein M1; C400551:GLI1 protein, human; D009363:Neoplasm Proteins; D000071676:Zinc Finger Protein GLI1