title: ARCPHdb: A comprehensive protein database for SF1 and SF2 helicase from archaea.
abstract: Superfamily 1 and Superfamily 2 helicases, two of the largest helicase protein families, play vital roles in many biological processes including replication, transcription and translation. Study of helicase proteins in the model microorganisms of archaea have largely contributed to the understanding of their function, architecture and assembly. Based on a large phylogenomics approach, we have identified and classified all SF1 and SF2 protein families in ninety five sequenced archaea genomes. Here we developed an online webserver linked to a specialized protein database named ARCPHdb to provide access for SF1 and SF2 helicase families from archaea.
  
  
  
  ARCPHdb was implemented using MySQL relational database. Web interfaces were developed using Netbeans. Data were stored according to UniProt accession numbers, NCBI Ref Seq ID, PDB IDs and Entrez Databases.
  
  
  
  A user-friendly interactive web interface has been developed to browse, search and download archaeal helicase protein sequences, their available 3D structure models, and related documentation available in the literature provided by ARCPHdb. The database provides direct links to matching external databases.
  
  
  
  The ARCPHdb is the first online database to compile all protein information on SF1 and SF2 helicase from archaea in one platform. This database provides essential resource information for all researchers interested in the field.
authors.affiliation: Centre Azm pour la recherche en Biotechnologie et ses applications, Ecole Doctorale Sciences et Technologies, Mitein Street, Tripoli, Lebanon.
authors.forename: Mirna
authors.initials: M
authors.lastname: Moukhtar
authors.affiliation: Hloul Business Analytics Solutions, Omar Daouk Street, Beirut, Lebanon.
authors.forename: Wafi
authors.initials: W
authors.lastname: Chaar
authors.affiliation: Laboratoire de Biotechnologies appliquées, Centre Azm pour la recherche en Biotechnologie et ses applications, Ecole Doctorale Sciences et Technologies, Mitein Street, Tripoli, Lebanon.
authors.forename: Ziad
authors.initials: Z
authors.lastname: Abdel-Razzak
authors.affiliation: Centre Azm pour la recherche en Biotechnologie et ses applications, Ecole Doctorale Sciences et Technologies, Mitein Street, Tripoli, Lebanon.
authors.forename: Mohamad
authors.initials: M
authors.lastname: Khalil
authors.affiliation: Laboratoire de Biotechnologies appliquées, Centre Azm pour la recherche en Biotechnologie et ses applications, Ecole Doctorale Sciences et Technologies, Mitein Street, Tripoli, Lebanon.
authors.forename: Samir
authors.initials: S
authors.lastname: Taha
authors.affiliation: Laboratoire de Biotechnologies appliquées, Centre Azm pour la recherche en Biotechnologie et ses applications, Ecole Doctorale Sciences et Technologies, Mitein Street, Tripoli, Lebanon; Faculty of Science, Department of Biology, Lebanese University, Tripoli, Lebanon. Electronic address: hala.chamieh@ul.edu.lb.
authors.forename: Hala
authors.initials: H
authors.lastname: Chamieh
mesh_terms: D001105:Archaea; D019843:Archaeal Proteins; D019295:Computational Biology; D003628:Database Management Systems; D030562:Databases, Protein; D020365:RNA Helicases; D014584:User-Computer Interface
chemical_list: D019843:Archaeal Proteins; D020365:RNA Helicases
keywords: Archaea; Protein database; Superfamily helicase 1; Superfamily helicase 2