title: Prevalence of posterior vitreous detachment in glaucoma patients and controls.
abstract: OBJECTIVE
  To evaluate the impact of oxidative stress - present in glaucoma - on the vitreous. We therefore compare the presence of early and late stages of posterior vitreous detachment (PVD) between patients with glaucoma and controls.
  
  
  METHODS
  The vitreous state was evaluated by the combination of optical coherence tomography and ultrasound. The main outcome was the vitreous state classified into 'no PVD', 'initial PVD' and 'advanced PVD'.
  
  
  RESULTS
  We evaluated the vitreous state in 48 patients with glaucoma (age: mean 66.5 ± 11.9 years; visual field deviation: mean 10.4 ± 6.8 dB) and compared the results with 101 previously investigated controls (age: mean 73.6 ± 9.3 years). After one-to-one matching on age and sex, ordinal logistic regression revealed that patients with glaucoma were significantly more likely to exhibit advanced PVD stages compared to non-glaucoma patients (OR 2.60, 95% confidence interval: 1.06-6.36, p = 0.037).
  
  
  CONCLUSIONS
  Our results suggest that the presence or absence of PVD might be a valuable hint for diagnosing glaucoma - however, further research is needed to determine whether PVD can be used to supplement current glaucoma screening guidelines.
authors.affiliation: Departement of Ophthalmology, Medical University of Graz, Graz, Austria.
authors.forename: Christoph
authors.initials: C
authors.lastname: Schwab
authors.affiliation: Departement of Ophthalmology, Medical University of Graz, Graz, Austria.
authors.forename: Wilfried
authors.initials: W
authors.lastname: Glatz
authors.affiliation: Departement of Ophthalmology, Medical University of Graz, Graz, Austria.
authors.forename: Bernd
authors.initials: B
authors.lastname: Schmidt
authors.affiliation: Departement of Ophthalmology, Medical University of Graz, Graz, Austria.
authors.forename: Ewald
authors.initials: E
authors.lastname: Lindner
authors.affiliation: Institute of Physiological Chemistry, Medical University of Graz, Graz, Austria.
authors.forename: Karl
authors.initials: K
authors.lastname: Oettl
authors.affiliation: Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria.
authors.forename: Regina
authors.initials: R
authors.lastname: Riedl
authors.affiliation: Departement of Ophthalmology, Medical University of Graz, Graz, Austria.
authors.forename: Andreas
authors.initials: A
authors.lastname: Wedrich
authors.affiliation: Departement of Ophthalmology, Medical University of Graz, Graz, Austria.
authors.forename: Domagoj
authors.initials: D
authors.lastname: Ivastinovic
authors.affiliation: Departement of Ophthalmology, Medical University of Graz, Graz, Austria.
authors.forename: Michaela
authors.initials: M
authors.lastname: Velikay-Parel
authors.affiliation: Departement of Ophthalmology, Medical University of Graz, Graz, Austria.
authors.forename: Georg
authors.initials: G
authors.lastname: Mossboeck
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001317:Austria / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D005901:Glaucoma / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009887:Ophthalmoscopy; D015995:Prevalence; D011446:Prospective Studies; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods*; D014463:Ultrasonography; D014822:Vitreous Body / Q000000981:diagnostic imaging*; D020255:Vitreous Detachment / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology
keywords: free radicals; glaucoma; oxidative stress; posterior vitreous detachment; vitreous liquefaction