title: Gene polymorphisms of pathogenicHelicobacter pyloriin patients with different types of gastrointestinal diseases.
abstract: Helicobacter pylori(H. pylori) is a kind of chronic infectious pathogen which can cause chronic gastritis, peptic ulcer, gastric cancer and other diseases. The genetic structure of the pathogenic genes ofH. pylorivaries largely, which contributes to the differences in virulence among various strains, and in clinical symptoms. Virulence genes ofH. pylorican be categorized into three main classes: those related to adhesion and colonization, those related to gastric mucosal injury, and others. This review focuses on the relationship between genetic polymorphisms of the three classes of virulence genes ofH. pyloriand diseases. Most of the genetic polymorphisms of the main virulence factors ofH. pyloriare summarized in this paper.
authors.affiliation: Yu-Li Chen, Xiao-Qiang Mo, Gan-Rong Huang, Yan-Qiang Huang, Juan Xiao, Li-Juan Zhao, Hong-Yu Wei, Qian Liang, Department of Medical Microbiology and Immunology, Youjiang Medical University for Nationalities, Baise 533000, Guangxi Zhuang Autonomous Region, China.
authors.forename: Yu-Li
authors.initials: YL
authors.lastname: Chen
authors.affiliation: Yu-Li Chen, Xiao-Qiang Mo, Gan-Rong Huang, Yan-Qiang Huang, Juan Xiao, Li-Juan Zhao, Hong-Yu Wei, Qian Liang, Department of Medical Microbiology and Immunology, Youjiang Medical University for Nationalities, Baise 533000, Guangxi Zhuang Autonomous Region, China.
authors.forename: Xiao-Qiang
authors.initials: XQ
authors.lastname: Mo
authors.affiliation: Yu-Li Chen, Xiao-Qiang Mo, Gan-Rong Huang, Yan-Qiang Huang, Juan Xiao, Li-Juan Zhao, Hong-Yu Wei, Qian Liang, Department of Medical Microbiology and Immunology, Youjiang Medical University for Nationalities, Baise 533000, Guangxi Zhuang Autonomous Region, China.
authors.forename: Gan-Rong
authors.initials: GR
authors.lastname: Huang
authors.affiliation: Yu-Li Chen, Xiao-Qiang Mo, Gan-Rong Huang, Yan-Qiang Huang, Juan Xiao, Li-Juan Zhao, Hong-Yu Wei, Qian Liang, Department of Medical Microbiology and Immunology, Youjiang Medical University for Nationalities, Baise 533000, Guangxi Zhuang Autonomous Region, China.
authors.forename: Yan-Qiang
authors.initials: YQ
authors.lastname: Huang
authors.affiliation: Yu-Li Chen, Xiao-Qiang Mo, Gan-Rong Huang, Yan-Qiang Huang, Juan Xiao, Li-Juan Zhao, Hong-Yu Wei, Qian Liang, Department of Medical Microbiology and Immunology, Youjiang Medical University for Nationalities, Baise 533000, Guangxi Zhuang Autonomous Region, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Xiao
authors.affiliation: Yu-Li Chen, Xiao-Qiang Mo, Gan-Rong Huang, Yan-Qiang Huang, Juan Xiao, Li-Juan Zhao, Hong-Yu Wei, Qian Liang, Department of Medical Microbiology and Immunology, Youjiang Medical University for Nationalities, Baise 533000, Guangxi Zhuang Autonomous Region, China.
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Zhao
authors.affiliation: Yu-Li Chen, Xiao-Qiang Mo, Gan-Rong Huang, Yan-Qiang Huang, Juan Xiao, Li-Juan Zhao, Hong-Yu Wei, Qian Liang, Department of Medical Microbiology and Immunology, Youjiang Medical University for Nationalities, Baise 533000, Guangxi Zhuang Autonomous Region, China.
authors.forename: Hong-Yu
authors.initials: HY
authors.lastname: Wei
authors.affiliation: Yu-Li Chen, Xiao-Qiang Mo, Gan-Rong Huang, Yan-Qiang Huang, Juan Xiao, Li-Juan Zhao, Hong-Yu Wei, Qian Liang, Department of Medical Microbiology and Immunology, Youjiang Medical University for Nationalities, Baise 533000, Guangxi Zhuang Autonomous Region, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Liang
mesh_terms: D005767:Gastrointestinal Diseases / Q000175:diagnosis / Q000382:microbiology*; D005838:Genotype; D016481:Helicobacter Infections / Q000175:diagnosis / Q000382:microbiology*; D016480:Helicobacter pylori / Q000235:genetics* / Q000472:pathogenicity; D054884:Host-Pathogen Interactions; D006801:Humans; D010641:Phenotype; D011110:Polymorphism, Genetic; D014774:Virulence; D037521:Virulence Factors / Q000235:genetics*
chemical_list: D037521:Virulence Factors
keywords: Gastrointestinal disease; Helicobacter pylori; Pathogenic gene; Polymorphism