title: [Association between human papillomavirus infection and lung cancer].
abstract: Objective:To investigate the association between human papillomavirus (HPV) and lung cancer.Methods:We examined a series of 83 lung cancer patients with HPV DNA in both lung tumor specimens and adjacent normal specimens from Fujian province. Twenty-one of the most clinically relevant HPV types from the highly conserved L1 region of the viral genome were analyzed, using the PCR amplification and were followed by reverse hybridization with specific probes. Chi-square test of paired design was used to test the difference of HPV positive rates between lung cancer specimens and adjacent normal specimens. Chi-square test and Fisher's exact test were used to analyze the differences of HPV positive rate of tumor specimens on factors as gender, age, histological subtype, clinical stage, smoking status and alcohol consumption.Results:HPV was detected in 7 of the 83 tumor specimens and in 6 of the paired normal lung tissues. There was no significant correlation between HPV and lung cancer (P>0.999). Neither demographic characteristics nor clinical features were found with significant differences on HPV in lung cancer tissues (P>0.05).Conclusion:Our data showed that HPV was not significantly associated with the risk of lung cancer in Fujian province.
authors.affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou 350108, China.
authors.forename: W M
authors.initials: WM
authors.lastname: Xiong
authors.affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou 350108, China.
authors.forename: F
authors.initials: F
authors.lastname: He
authors.affiliation: Department of Chest Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350001, China.
authors.forename: R D
authors.initials: RD
authors.lastname: Xiao
authors.affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou 350108, China.
authors.forename: T T
authors.initials: TT
authors.lastname: Yu
authors.affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou 350108, China.
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou 350108, China.
authors.forename: Z Q
authors.initials: ZQ
authors.lastname: Liu
authors.affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou 350108, China.
authors.forename: Q P
authors.initials: QP
authors.lastname: Xu
authors.affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou 350108, China.
authors.forename: L
authors.initials: L
authors.lastname: Cai
mesh_terms: D006801:Humans; D008175:Lung Neoplasms; D027383:Papillomaviridae; D030361:Papillomavirus Infections; D016133:Polymerase Chain Reaction; D012907:Smoking