title: Exploring the nexus of Alzheimer's disease and related dementias with cancer and cancer therapies: A convening of the Alzheimer's Association & Alzheimer's Drug Discovery Foundation.
abstract: Recent population studies suggest an intriguing inverse relationship between several types of cancer and neurodegenerative diseases, including Alzheimer's disease. Understanding the intersection of the underlying biology for these two distinct families of diseases with one another may offer novel approaches to identify new therapeutic approaches and possible opportunities to repurpose existing drug candidates. The Alzheimer's Association and the Alzheimer's Drug Discovery Foundation convened a one-day workshop to delve into this discussion. Workshop participants outlined research focus areas, potential collaborations, and partnerships for future action.
authors.affiliation: Division of Medical and Scientific Relations, Alzheimer's Association, Chicago, IL, USA. Electronic address: hsnyder@alz.org.
authors.forename: Heather M
authors.initials: HM
authors.lastname: Snyder
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
authors.forename: Tim
authors.initials: T
authors.lastname: Ahles
authors.affiliation: Radiation Oncology, Harvard University Medical School, Boston, MA, USA.
authors.forename: Stuart
authors.initials: S
authors.lastname: Calderwood
authors.affiliation: Division of Medical and Scientific Relations, Alzheimer's Association, Chicago, IL, USA.
authors.forename: Maria C
authors.initials: MC
authors.lastname: Carrillo
authors.affiliation: Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI, USA.
authors.forename: Honglei
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Biostatistics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA; Department of Biostatistics, University of Pittsburgh Medical School, Pittsburgh, PA, USA; Clinical and Translational Science, University of Pittsburgh Medical School, Pittsburgh, PA, USA.
authors.forename: Chung-Chou H
authors.initials: CH
authors.lastname: Chang
authors.affiliation: Division of Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University of Medicine, Winston-Salem, NC, USA.
authors.forename: Suzanne
authors.initials: S
authors.lastname: Craft
authors.affiliation: Geriatric Research Education and Clinical Center, VA Boston HealthCare System, Boston, MA, USA.
authors.forename: Philip
authors.initials: P
authors.lastname: De Jager
authors.affiliation: Division of Aging, Brigham and Women's Hospital, Boston, MA, USA; Department of Medicine, Harvard University Medical School, Boston, MA, USA.
authors.forename: Jane A
authors.initials: JA
authors.lastname: Driver
authors.affiliation: Scientific Affairs, Alzheimer's Drug Discovery Foundation, New York, NY, USA.
authors.forename: Howard
authors.initials: H
authors.lastname: Fillit
authors.affiliation: Department of Neurology, Mayo Clinic, Rochester, MN, USA.
authors.forename: David
authors.initials: D
authors.lastname: Knopman
authors.affiliation: Departments of Surgery, Immunology and Bioengineering, University of Pittsburgh Medical School, Pittsburgh, PA, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Lotze
authors.affiliation: Department of Family and Community Medicine, Sunnybrook Health Science Center, Toronto, Ontario, Canada.
authors.forename: Mary C
authors.initials: MC
authors.lastname: Tierney
authors.affiliation: Division of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Suzana
authors.initials: S
authors.lastname: Petanceska
authors.affiliation: Department of Radiology, Indiana University School of Medicine, Indianapolis, IN, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Saykin
authors.affiliation: Division of Neurology, Boston University Medical School, Boston, MA, USA.
authors.forename: Sudha
authors.initials: S
authors.lastname: Seshadri
authors.affiliation: Scientific Affairs, Alzheimer's Drug Discovery Foundation, New York, NY, USA.
authors.forename: Diana
authors.initials: D
authors.lastname: Shineman
authors.affiliation: Professor of Psychiatry, Neurology, and Epidemiology, University of Pittsburgh School of Medicine and Graduate School of Public Health, Pittsburgh, PA, USA.
authors.forename: Mary
authors.initials: M
authors.lastname: Ganguli
mesh_terms: D000544:Alzheimer Disease / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003704:Dementia / Q000150:complications* / Q000453:epidemiology; D055808:Drug Discovery; D006801:Humans; D009369:Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000628:therapy
chemical_list: D000970:Antineoplastic Agents
keywords: Alzheimer's disease; Biological mechanisms; Cancer; Epidemiology; Genetics; Oncology; Repurpose therapy