title: Adjunct Intravitreous Triamcinolone Acetonide in the Treatment of Diabetic Macular Edema with Anti-VEGF Agents.
abstract: Aims.To compare visual and anatomic outcomes of adjunct intravitreous (IVT) triamcinolone acetonide to antivascular endothelial growth factor (VEGF) injections to IVT anti-VEGF injections alone for center-involving diabetic macular edema (DME) in treatment-naïve eyes.Methods.Retrospective study of treatment-naïve eyes with center-involving DME. The primary outcome was the change in best corrected visual acuity (BCVA) in eyes receiving only IVT anti-VEGF (group 1) and eyes receiving IVT anti-VEGF and adjunct IVT-TA (group 2).Results.Included were 192 eyes. The mean change in BCVA was +3.5 letters in group 1 compared to -3.5 letters in group 2 (p= 0.048). Final macular thickness improved by -94μm in group 1 versus -68μm in group 2 (p= 0.26). In group 1, 5/150 eyes compared to 9/42 eyes in group 2 (3.3% versus 21%,p= 0.0005) had a IOP >10 mmHg increase. Six of 126 phakic eyes in group 1 versus 12/33 phakic eyes in group 2 underwent cataract surgery (4.7% versus 36.3%,p= 0.00009).Conclusions.IVT-TA results in no additional benefit in eyes treated with anti-VEGF agents for DME.
authors.affiliation: Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA; Cullen Eye Institute, Baylor College of Medicine, Houston, TX, USA.
authors.forename: Robert B
authors.identifier: 0000-0002-7537-191X
authors.initials: RB
authors.lastname: Garoon
authors.affiliation: Cullen Eye Institute, Baylor College of Medicine, Houston, TX, USA.
authors.forename: Robert E
authors.initials: RE
authors.lastname: Coffee
authors.affiliation: School of Medicine, Baylor College of Medicine, Houston, TX, USA.
authors.forename: Lai
authors.initials: L
authors.lastname: Jiang
authors.affiliation: Cullen Eye Institute, Baylor College of Medicine, Houston, TX, USA.
authors.forename: Christina Y
authors.initials: CY
authors.lastname: Weng
authors.affiliation: Cullen Eye Institute, Baylor College of Medicine, Houston, TX, USA.
authors.forename: Petros E
authors.identifier: 0000-0002-3879-3486
authors.initials: PE
authors.lastname: Carvounis