title: Dual-Functionality Fullerene and Silver Nanoparticle Antimicrobial Composites via Block Copolymer Templates.
abstract: We present the facile prepartion of C70and Ag nanoparticle (NP) loaded block copolymer (BCP) thin films, with C70and Ag NPs working in tandem to provide virucidal and bactericidal activities, respectively. Polystyrene-block-poly-4-vinylpyridine (PS-P4VP) was used as a template, allowing C70integration into PS domains and in situ formation of Ag NPs in P4VP domains, while providing control of the nanoscale spatial distribution of functionality as a function of BCP molecular weight (MW). C70loaded PS-P4VP films were found to generate significant amounts of1O2under visible light illumination with no apparent dependence on BCP MW. An analogous C70loaded PS homopolymer film produced notably less1O2, highlighting a possible critical role of morphology on C70photoactivity. The antimicrobial activity of Ag NP and C70loaded composites against the model PR772 bacteriophage and Escherichia coli was assessed, finding synergistic inactivation afforded by the dual functionality. BCPs were demonstrated as versatile platforms for the preparation of multifunctional antimicrobial coatings toward combating diverse microbial communities.
authors.affiliation: Department of Chemical & Environmental Engineering, School of Engineering & Applied Science, Yale University , 9 Hillhouse Avenue, New Haven, Connecticut 06511, United States.
authors.forename: Kyle J
authors.initials: KJ
authors.lastname: Moor
authors.affiliation: Department of Chemical & Environmental Engineering, School of Engineering & Applied Science, Yale University , 9 Hillhouse Avenue, New Haven, Connecticut 06511, United States.
authors.forename: Chinedum O
authors.initials: CO
authors.lastname: Osuji
authors.affiliation: Department of Chemical & Environmental Engineering, School of Engineering & Applied Science, Yale University , 9 Hillhouse Avenue, New Haven, Connecticut 06511, United States.
authors.forename: Jae-Hong
authors.initials: JH
authors.lastname: Kim
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry*; D037741:Fullerenes; D053768:Metal Nanoparticles; D049329:Nanostructures; D011145:Polyvinyls; D012834:Silver; D013499:Surface Properties
chemical_list: D000890:Anti-Infective Agents; D037741:Fullerenes; D011145:Polyvinyls; D012834:Silver
keywords: antimicrobial coating; block copolymer; fullerene; nanocomposite; silver nanoparticle