title: Thermochemical Properties of Hydrophilic Polymers from Cashew and Khaya Exudates and Their Implications on Drug Delivery.
abstract: Characterization of a polymer is essential for determining its suitability for a particular purpose. Thermochemical properties of cashew gum (CSG) extracted from exudates ofAnacardium occidentale L.and khaya gum (KYG) extracted from exudates ofKhaya senegalensiswere determined and compared with those of acacia gum BP (ACG). The polymers were subjected to different thermal and chemical analyses. Exudates of CSG contained higher amount of hydrophilic polymer. The pH of 2% w/v gum dispersions was in the order KYG < CSG < ACG. Calcium was the predominant ion in CSG while potassium was predominant in KYG. The FTIR spectra of CSG and KYG were similar and slightly different from that of ACG. Acacia and khaya gums exhibited the same thermal behaviour which is different from that of CSG. X-ray diffraction revealed that the three gums are the same type of polymer, the major difference being the concentration of metal ions. This work suggests the application of cashew gum for formulation of basic and oxidizable drugs while using khaya gum for acidic drugs.
authors.affiliation: Department of Pharmaceutics and Pharmaceutical Technology, University of Uyo, Uyo, Nigeria; Department of Pharmaceutics and Pharmaceutical Microbiology, Ahmadu Bello University, Zaria, Nigeria.
authors.forename: Emmanuel O
authors.identifier: 0000-0002-6041-2563
authors.initials: EO
authors.lastname: Olorunsola
authors.affiliation: Department of Pharmaceutics and Pharmaceutical Microbiology, Usmanu Danfodiyo University, Sokoto, Nigeria.
authors.forename: Partap G
authors.initials: PG
authors.lastname: Bhatia
authors.affiliation: Department of Pharmaceutics and Pharmaceutical Microbiology, Ahmadu Bello University, Zaria, Nigeria.
authors.forename: Babajide A
authors.initials: BA
authors.lastname: Tytler
authors.affiliation: University of Abuja, Abuja, Nigeria.
authors.forename: Michael U
authors.initials: MU
authors.lastname: Adikwu