title: Synthesis and Cytotoxic Evaluation of Pyrrole Hetarylazoles Containing Benzimidazole/Pyrazolone/1,3,4-Oxadiazole Motifs.
abstract: Azomethine linked pyrrole bishetarylazoles containing benzimidazole/pyrazolone/1,3,4-oxadiazole were synthesized in satisfactory yields. Their structures were confirmed by IR,1H-NMR,13C-NMR and elemental analysis. Evaluation for the cytotoxic activitiesIn vitroagainst a panel of breast cancer cell lines (MDA-AB-231, BT-474 and Ishikawa cells) revealed that the pyrrole-benzimidazole hybrids are more potent than the pyrazolone and 1,3,4-oxadiazole hybrids in all cell lines. Compound (9) displayed promising cytotoxicity against BT-474 cell line with IC50values, 7.7 µM.
authors.affiliation: Department of Chemistry, College of Science and Technology, Florida A&M University, Tallahassee, FL 32307.
authors.forename: Bereket
authors.initials: B
authors.lastname: Mochona
authors.affiliation: Department of Chemistry, College of Science and Technology, Florida A&M University, Tallahassee, FL 32307.
authors.forename: Timothy
authors.initials: T
authors.lastname: Jackson
authors.affiliation: Department of Chemistry, College of Science and Technology, Florida A&M University, Tallahassee, FL 32307.
authors.forename: DeCoria
authors.initials: D
authors.lastname: McCauley
authors.affiliation: College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee, FL 32307.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Mazzio
authors.affiliation: College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee, FL 32307.
authors.forename: Kinfe K
authors.initials: KK
authors.lastname: Redda