title: Metabolic signaling functions of ER-mitochondria contact sites: role in metabolic diseases.
abstract: Beyond the maintenance of cellular homeostasis and the determination of cell fate, ER-mitochondria contact sites, defined as mitochondria-associated membranes (MAM), start to emerge as an important signaling hub that integrates nutrient and hormonal stimuli and adapts cellular metabolism. Here, we summarize the established structural and functional features of MAM and mainly focus on the latest breakthroughs highlighting a crucial role of organelle crosstalk in the control of metabolic homeostasis. Lastly, we discuss recent studies that have revealed the importance of MAM in not only metabolic diseases but also in other pathologies with disrupted metabolism, shedding light on potential common molecular mechanisms and leading hopefully to novel treatment strategies.
authors.affiliation: Department of Clinical SciencesLund University Diabetes Centre, Malmö, Sweden.
authors.forename: Emily
authors.initials: E
authors.lastname: Tubbs
authors.affiliation: INSERM UMR-1060CarMeN Laboratory, Lyon 1 University, INRA U1235, INSA of Lyon, Charles Merieux Lyon-Sud medical Universities, Lyon, France jennifer.rieusset@univ-lyon1.fr.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Rieusset
mesh_terms: D000818:Animals; D001343:Autophagy; D002118:Calcium / Q000378:metabolism; D020013:Calcium Signaling; D004198:Disease Susceptibility; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D004734:Energy Metabolism; D006801:Humans; D056747:Immunomodulation; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance; D008659:Metabolic Diseases / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism*; D051336:Mitochondrial Membranes / Q000737:chemistry / Q000378:metabolism; D010084:Oxidation-Reduction; D015398:Signal Transduction; D013329:Structure-Activity Relationship; D056811:Unfolded Protein Response
chemical_list: D007328:Insulin; D002118:Calcium
keywords: PP2A; calcium signaling; insulin resistance; metabolic homeostasis; mitochondria-associated membranes; organelle communication; type 2 diabetes mellitus