title: Diagnostic Value of Fecal Calprotectin (S100 A8/A9) Test in Children with Chronic Abdominal Pain.
abstract: Objectives. The aim of the study was to establish whether fecal calprotectin concentration (FCC) may be useful in children with chronic abdominal pain to differentiate between inflammatory bowel disease (IBD), other inflammatory gastrointestinal disorders, and functional gastrointestinal disorders.Methods. The study included 163 patients (median age 13 years), who were assigned to four study groups: group 0 (control), 22 healthy children; group 1, 33 children with functional gastrointestinal disorders; group 2, 71 children with inflammatory gastrointestinal disorders other than IBD; group 3, 37 children with IBD. FCC was measured using ELISA assay.Results. In group 0 and group 1 FCCs were below 100μg/g. Low FCCs were found in 91% of patients in group 2. In patients with IBD FCCs were markedly elevated with median value of 1191.5μg/g. However, in children with inflammatory gastrointestinal disorders other than IBD and in children with IBD mean FCCs were significantly higher compared with the control group. Significant differences in FCCs were also found between group 1 and group 2, between group 1 and group 3, and between group 2 and group 3.Conclusion. FCC is the best parameter allowing for differentiation between IBD, other inflammatory gastrointestinal disorders, and functional gastrointestinal disorders. High FCC is associated with a high probability of IBD and/or other inflammatory gastrointestinal disorders, and it allows excluding functional gastrointestinal disorders.
authors.affiliation: Department of Pediatrics, Gastroenterology and Nutrition, Pediatric Institute College of Medicine, Jagiellonian University, Cracow, Poland.
authors.forename: Stanisław
authors.identifier: 0000-0001-7680-0969
authors.initials: S
authors.lastname: Pieczarkowski
authors.affiliation: Department of Pediatrics, Gastroenterology and Nutrition, Pediatric Institute College of Medicine, Jagiellonian University, Cracow, Poland.
authors.forename: Kinga
authors.initials: K
authors.lastname: Kowalska-Duplaga
authors.affiliation: Department of Pediatrics, Pediatric Institute College of Medicine, Jagiellonian University, Cracow, Poland.
authors.forename: Przemko
authors.identifier: 0000-0002-3017-0348
authors.initials: P
authors.lastname: Kwinta
authors.affiliation: Department of Clinical Biochemistry, Pediatric Institute College of Medicine, Jagiellonian University, Cracow, Poland.
authors.forename: Przemysław
authors.identifier: 0000-0002-2061-999X
authors.initials: P
authors.lastname: Tomasik
authors.affiliation: Department of Pediatrics, Gastroenterology and Nutrition, Pediatric Institute College of Medicine, Jagiellonian University, Cracow, Poland.
authors.forename: Andrzej
authors.identifier: 0000-0003-1448-167X
authors.initials: A
authors.lastname: Wędrychowicz
authors.affiliation: Department of Pediatrics, Gastroenterology and Nutrition, Pediatric Institute College of Medicine, Jagiellonian University, Cracow, Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Fyderek