title: DNA damage response in nephrotoxic and ischemic kidney injury.
abstract: DNA damage activates specific cell signaling cascades for DNA repair, cell cycle arrest, senescence, and/or cell death. Recent studies have demonstrated DNA damage response (DDR) in experimental models of acute kidney injury (AKI). In cisplatin-induced AKI or nephrotoxicity, the DDR pathway of ATR/Chk2/p53 is activated and contributes to renal tubular cell apoptosis. In ischemic AKI, DDR seems more complex and involves at least the ataxia telangiectasia mutated (ATM), a member of the phosphatidylinositol 3-kinase-related kinase (PIKK) family, and p53; however, while ATM may promote DNA repair, p53 may trigger cell death. Targeting DDR for kidney protection in AKI therefore relies on a thorough elucidation of the DDR pathways in various forms of AKI.
authors.affiliation: Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, PR China.
authors.forename: Mingjuan
authors.initials: M
authors.lastname: Yan
authors.affiliation: Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, PR China.
authors.forename: Chengyuan
authors.initials: C
authors.lastname: Tang
authors.affiliation: Department of Cellular Biology & Anatomy, Medical College of Georgia at Augusta University and Charlie Norwood VA Medical Center, Augusta, GA 30912, USA.
authors.forename: Zhengwei
authors.initials: Z
authors.lastname: Ma
authors.affiliation: Department of Anatomy and Cell Biology, University of Florida College of Medicine, Gainesville, FL, USA.
authors.forename: Shuang
authors.initials: S
authors.lastname: Huang
authors.affiliation: Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, PR China; Department of Cellular Biology & Anatomy, Medical College of Georgia at Augusta University and Charlie Norwood VA Medical Center, Augusta, GA 30912, USA. Electronic address: zdong@augusta.edu.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Dong
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced; D002945:Cisplatin / Q000633:toxicity; D004249:DNA Damage; D006801:Humans; D007511:Ischemia / Q000235:genetics*; D007668:Kidney / Q000098:blood supply*; D015427:Reperfusion Injury
chemical_list: D002945:Cisplatin
keywords: Acute kidney injury; Cisplatin; DNA damage response; Renal ischemia/reperfusion