title: Hyaluronic acid-coated nanoparticles for targeted photodynamic therapy of cancer guided by near-infrared and MR imaging.
abstract: In this study, the multifaceted properties of hyaluronic acid (HA) were used for the targeted therapy of cancer by photodynamic therapy (PDT) guided by molecular imaging. Near-infrared (NIR) photosensitizers (Chlorin e6; Ce6) were encapsulated into poly(lactic-co-glycolic acid) nanoparticles (PLGA NPs) coated with HA that can act as CD44 targeting ligand. The abundant carboxylate groups of HA also enabled the chelation of gadolinium ions (Gd3+), T1-weighted MRI contrast agents, on the surface of PLGA NPs. Through both in vitro and in vivo fluorescence and MRI signal analysis, we confirmed that the HA-Gd-Ce6-PLGA NPs (HAGCP-NPs) could efficiently target CD44-overexpressing A549 cancer cells. When an NIR laser was illuminated to irradiate A549 tumor-bearing mice, the groups treated with HAGCP-NPs showed remarkable delays in tumor growth or tumor regression. Taken together, the HAGCP-NPs are expected to be used as a theranostic platform for the dual modal (MR/NIR) imaging and PDT of cancer.
authors.affiliation: SKKU Advanced Institute of Nanotechnology (SAINT), School of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea; Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon 34134, Republic of Korea.
authors.forename: Kyung Eun
authors.initials: KE
authors.lastname: Park
authors.affiliation: SKKU Advanced Institute of Nanotechnology (SAINT), School of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea.
authors.forename: Young-Woock
authors.initials: YW
authors.lastname: Noh
authors.affiliation: SKKU Advanced Institute of Nanotechnology (SAINT), School of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea.
authors.forename: Ahreum
authors.initials: A
authors.lastname: Kim
authors.affiliation: SKKU Advanced Institute of Nanotechnology (SAINT), School of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea. Electronic address: yongtaik@skku.edu.
authors.forename: Yong Taik
authors.initials: YT
authors.lastname: Lim
mesh_terms: D000072283:A549 Cells; D000818:Animals; D006801:Humans; D006820:Hyaluronic Acid; D008279:Magnetic Resonance Imaging; D051379:Mice; D053758:Nanoparticles; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000494:pharmacology*
chemical_list: D017319:Photosensitizing Agents; D006820:Hyaluronic Acid
keywords: Cancer therapy; Hyaluronic acid; MRI; Near-infrared; Photodynamic therapy