title: Role of fetal MRI in the evaluation of isolated and non-isolated corpus callosum dysgenesis: results of a cross-sectional study.
abstract: OBJECTIVE
  The aims of this study were to characterize isolated and non-isolated forms of corpus callosum dysgenesis (CCD) at fetal magnetic resonance imaging (MRI) and to identify early predictors of associated anomalies.
  
  
  METHODS
  We retrospectively analyzed 104 fetuses with CCD undergoing MRI between 2006 and 2016. Corpus callosum, cavum septi pellucidi, biometry, presence of ventriculomegaly, gyration anomalies, cranio-encephalic abnormalities and body malformations were evaluated. Results of genetic tests were also recorded.
  
  
  RESULTS
  At MRI, isolated CCD was 26.9%, the rest being associated to other abnormalities. In the isolated group, median gestational age at MRI was lower in complete agenesis than in hypoplasia (22 vs 28 weeks). In the group with additional findings, cortical dysplasia was the most frequently associated feature (P = 0.008), with a more frequent occurrence in complete agenesis (70%) versus other forms; mesial frontal lobes were more often involved than other cortical regions (P = 0.006), with polymicrogyria as the most frequent cortical malformation (40%). Multivariate analysis confirmed the association between complete agenesis and cortical dysplasia (odds ratio = 7.29, 95% confidence interval 1.51-35.21).
  
  
  CONCLUSIONS
  CCD is often complicated by other intra-cranial and extra-cranial findings (cortical dysplasias as the most prevalent) that significantly affect the postnatal prognosis. The present study showed CCD with associated anomalies as more frequent than isolated (73.1%). In isolated forms, severe ventriculomegaly was a reliable herald of future appearance of associated features. © 2016 John Wiley & Sons, Ltd.
authors.affiliation: Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Rome, Italy.
authors.forename: Lucia
authors.initials: L
authors.lastname: Manganaro
authors.affiliation: Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Rome, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Bernardo
authors.affiliation: Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
authors.forename: Corrado
authors.initials: C
authors.lastname: De Vito
authors.affiliation: Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Rome, Italy.
authors.forename: Amanda
authors.initials: A
authors.lastname: Antonelli
authors.affiliation: Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.|Casa Sollievo della Sofferenza, Istituto Mendel, Rome, Italy.
authors.forename: Enrica
authors.initials: E
authors.lastname: Marchionni
authors.affiliation: Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Rome, Italy.
authors.forename: Valeria
authors.initials: V
authors.lastname: Vinci
authors.affiliation: Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Rome, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Saldari
authors.affiliation: Private Prenatal Diagnostic Centre 'Diagnostica ecografica Aniello Di Meglio s.r.l.', Naples, Italy.
authors.forename: Letizia
authors.initials: L
authors.lastname: Di Meglio
authors.affiliation: Department of Obstetrics, Gynecology and Urologic Sciences, Sapienza, University of Rome, Rome, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Giancotti
authors.affiliation: Surgical Pathology Unit, San Camillo Forlanini Hospital, Rome, Italy.
authors.forename: Evelina
authors.initials: E
authors.lastname: Silvestri
authors.affiliation: Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Rome, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Catalano
authors.affiliation: Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.|Casa Sollievo della Sofferenza, Istituto Mendel, Rome, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Pizzuti
mesh_terms: D000015:Abnormalities, Multiple / Q000175:diagnosis* / Q000453:epidemiology; D000328:Adult; D061085:Agenesis of Corpus Callosum / Q000175:diagnosis* / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D005865:Gestational Age; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods*; D011379:Prognosis; D012189:Retrospective Studies