title: A Rhodium(III) Complex as an Inhibitor of Neural Precursor Cell Expressed, Developmentally Down-Regulated 8-Activating Enzyme with in Vivo Activity against Inflammatory Bowel Disease.
abstract: We report herein the identification of the rhodium(III) complex [Rh(phq)2(MOPIP)]+(1) as a potent and selective ATP-competitive neural precursor cell expressed, developmentally down-regulated 8 (NEDD8)-activating enzyme (NAE) inhibitor. Structure-activity relationship analysis indicated that the overall organometallic design of complex 1 was important for anti-inflammatory activity. Complex 1 showed promising anti-inflammatory activity in vivo for the potential treatment of inflammatory bowel disease.
authors.affiliation: State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau , Taipa, Macao P. R China.
authors.forename: Hai-Jing
authors.initials: HJ
authors.lastname: Zhong
authors.affiliation: Department of Chemistry, Hong Kong Baptist University , T1303, Cha Chi-Ming Science Tower, Kowloon Tong, Hong Kong, P. R. China.
authors.forename: Wanhe
authors.initials: W
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau , Taipa, Macao P. R China.
authors.forename: Tian-Shu
authors.initials: TS
authors.lastname: Kang
authors.affiliation: Institute of New Drug Research and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine, Jinan University College of Pharmacy , Guangzhou 510632, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Yan
authors.affiliation: Institute of New Drug Research and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine, Jinan University College of Pharmacy , Guangzhou 510632, China.
authors.forename: Yali
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Institute of New Drug Research and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine, Jinan University College of Pharmacy , Guangzhou 510632, China.
authors.forename: Lipeng
authors.initials: L
authors.lastname: Xu
authors.affiliation: Institute of New Drug Research and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine, Jinan University College of Pharmacy , Guangzhou 510632, China.
authors.forename: Yuqiang
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Chemistry, Hong Kong Baptist University , T1303, Cha Chi-Ming Science Tower, Kowloon Tong, Hong Kong, P. R. China.
authors.forename: Dik-Lung
authors.identifier: 0000-0002-9515-340X
authors.initials: DL
authors.lastname: Ma
authors.affiliation: State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau , Taipa, Macao P. R China.
authors.forename: Chung-Hang
authors.initials: CH
authors.lastname: Leung
mesh_terms: D015536:Down-Regulation / Q000187:drug effects*; D006801:Humans; D000075687:NEDD8 Protein; D058953:Neural Stem Cells / Q000201:enzymology*; D012238:Rhodium / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014452:Ubiquitins / Q000037:antagonists & inhibitors*
chemical_list: D000075687:NEDD8 Protein; C082860:NEDD8 protein, human; D014452:Ubiquitins; D012238:Rhodium