title: Online Hemodiafiltration Reduces Bisphenol A Levels.
abstract: Several uremic toxins have been identified and related to higher rates of morbidity and mortality in dialysis patients. Bisphenol A (BPA) accumulates in patients with chronic kidney disease. The aim of this study is to demonstrate the usefulness of online hemodiafiltration (OL-HDF) in reducing BPA levels. Thirty stable hemodialysis patients were selected to participate in this paired study. During three periods of 3 weeks each, patients were switched from high-flux hemodialysis (HF-HD) to OL-HDF, and back to HF-HD. BPA levels were measured in the last session of each period (pre- and post-dialysis) using ELISA and HPLC. Twenty-two patients (mean age 73 ± 14 years; 86.4% males) were included. Measurements of BPA levels by HPLC and ELISA assays showed a weak but significant correlation (r = 0.218, P = 0.012). BPA levels decreased in the OL-HDF period of hemodialysis, in contrast to the HF-HD period when they remained stable (P = 0.002). In conclusion, OL-HDF reduced BPA levels in dialysis patients.
authors.affiliation: Nephrology Unit, Hospital Universitario de Guadalajara, Guadalajara, Spain.
authors.forename: Borja
authors.identifier: http://orcid.org/0000-0001-5730-1929
authors.initials: B
authors.lastname: Quiroga
authors.affiliation: Physiology Unit, Department of Systems Biology, Laboratory of Renal Physiology and Experimental Nephrology, Alcalá de Henares, Spain.
authors.forename: Ricardo J
authors.initials: RJ
authors.lastname: Bosch
authors.affiliation: Nephrology Unit, Hospital Universitario de Guadalajara, Guadalajara, Spain.
authors.forename: Ruth A
authors.initials: RA
authors.lastname: Fiallos
authors.affiliation: Nephrology Unit, Hospital Universitario de Guadalajara, Guadalajara, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Sánchez-Heras
authors.affiliation: Physiology Unit, Department of Systems Biology, Laboratory of Renal Physiology and Experimental Nephrology, Alcalá de Henares, Spain.
authors.forename: Nuria
authors.initials: N
authors.lastname: Olea-Herrero
authors.affiliation: Physiology Unit, Department of Systems Biology, Laboratory of Renal Physiology and Experimental Nephrology, Alcalá de Henares, Spain.
authors.forename: Pilar
authors.initials: P
authors.lastname: López-Aparicio
authors.affiliation: Physiology Unit, Department of Systems Biology, Laboratory of Renal Physiology and Experimental Nephrology, Alcalá de Henares, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Muñóz-Moreno
authors.affiliation: Physiology Unit, Department of Systems Biology, Laboratory of Renal Physiology and Experimental Nephrology, Alcalá de Henares, Spain.
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: Pérez-Alvarsan
authors.affiliation: Nephrology Unit, Hospital Universitario de Guadalajara, Guadalajara, Spain.|Medicine and Medicine Specialities Department, Universidad de Alcalá (UAH), Madrid, Spain.
authors.forename: Gabriel
authors.initials: G
authors.lastname: De Arriba
mesh_terms: D000368:Aged; D001559:Benzhydryl Compounds / Q000097:blood*; D002851:Chromatography, High Pressure Liquid; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D017583:Hemodiafiltration / Q000379:methods*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy*; D008297:Male; D010636:Phenols / Q000097:blood*; D011446:Prospective Studies; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: Bisphenol A; Hemodialysis; Online hemodiafiltration; Uremic toxins