title: Magnetic solid phase extraction with CoFe2O4/oleic acid nanoparticles coupled to gas chromatography-mass spectrometry for the determination of alkylphenols in baby foods.
abstract: Magnetic solid phase extraction (MSPE) with cobalt ferrite nanoparticles coated with oleic acid is described for the determination of alkylphenols (APs), 4-tert-butylphenol (TBP), 4-pentylphenol (PP), 4-hexylphenol (HP), 4-tert-octylphenol (TOP), 4-n-octylphenol (OP) and 4-nonylphenol (NP) in baby foods using gas chromatography with mass spectrometry (GC-MS). Prior to MSPE, the sample was treated with trichloroacetic acid, and the APs derivatized with acetic anhydride. Parameters affecting the extraction efficiency: amount of magnetic nanoparticles, extraction time and desorption conditions, were optimized. The enriched phase obtained was evaporated to dryness and the residue reconstituted in 50μL of methanol, 1μL of which was injected into the GC-MS. Samples were quantified applying matrix-matched calibration and using 2-chloro-5-bromoanisole as surrogate standard. The analysis of 0.5g of sample provided detection limits in the 0.4-1.7ngg-1range. Some samples contained APs at levels of between 3ngg-1for HP and 122ngg-1for TOP.
authors.affiliation: Department of Analytical Chemistry, Faculty of Chemistry, Regional Campus of International Excellence "Campus Mare Nostrum", University of Murcia, E-30100 Murcia, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Pastor-Belda
authors.affiliation: Department of Analytical Chemistry, Faculty of Chemistry, Regional Campus of International Excellence "Campus Mare Nostrum", University of Murcia, E-30100 Murcia, Spain.
authors.forename: Pilar
authors.initials: P
authors.lastname: Viñas
authors.affiliation: Department of Analytical Chemistry, Faculty of Chemistry, Regional Campus of International Excellence "Campus Mare Nostrum", University of Murcia, E-30100 Murcia, Spain.
authors.forename: Natalia
authors.initials: N
authors.lastname: Campillo
authors.affiliation: Department of Analytical Chemistry, Faculty of Chemistry, Regional Campus of International Excellence "Campus Mare Nostrum", University of Murcia, E-30100 Murcia, Spain. Electronic address: hcordoba@um.es.
authors.forename: Manuel
authors.initials: M
authors.lastname: Hernández-Córdoba
mesh_terms: D003035:Cobalt / Q000737:chemistry*; D005290:Ferric Compounds / Q000737:chemistry*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D006801:Humans; D007223:Infant; D007225:Infant Food / Q000032:analysis*; D053758:Nanoparticles / Q000032:analysis; D019301:Oleic Acid / Q000737:chemistry*; D010636:Phenols / Q000032:analysis*; D052616:Solid Phase Extraction / Q000379:methods
chemical_list: D005290:Ferric Compounds; D010636:Phenols; C569492:cobalt ferrite; D019301:Oleic Acid; D003035:Cobalt
keywords: Alkylphenols; Gas chromatography-mass spectrometry; Infant formulas; Magnetic nanoparticles