title: Construction of silver sulfadiazine loaded chitosan composite sponges as potential wound dressings.
abstract: Chitosan/silver sulfadiazine (CS/AgSD) composite sponges were prepared by incorporating AgSD particles into CS matrix in order to develop novel biomaterials for wound healing. The co-existence of CS and AgSD in the composite sponges was confirmed by SEM, FTIR and XRD spectra, respectively. The porosity and swelling properties of the fabricated CS/AgSD composite sponges were examined and the results indicated that they had high porosity and excellent swelling behaviors. Antibacterial property of the CS/AgSD composite sponges was also performed against E. coli, C. albicans, S. aureus and B. subtilis, respectively. The results showed that they possessed broad spectrum of antibacterial activity. The cytotoxicity of the prepared composite sponges was performed by MTT viability assay and fluorescence staining method on HEK293 cell lines. The cell viability results indicated that the designed sponges had no significant cytotoxicity. The results of this study demonstrated that the CS/AgSD composite sponges have potential application in antimicrobial wound dressing materials.
authors.affiliation: College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, PR China; Jiangsu Key Lab of Biomass Based Green Fuels and Chemicals, Nanjing 210037, PR China. Electronic address: w.shao@njfu.edu.cn.
authors.forename: Wei
authors.initials: W
authors.lastname: Shao
authors.affiliation: College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, PR China.
authors.forename: Jimin
authors.initials: J
authors.lastname: Wu
authors.affiliation: College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, PR China.
authors.forename: Shuxia
authors.initials: S
authors.lastname: Wang
authors.affiliation: College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, PR China.
authors.forename: Min
authors.initials: M
authors.lastname: Huang
authors.affiliation: State Key Laboratory of Natural Medicines, Department of Biotechnology of TCM, China Pharmaceutical University, Nanjing 210009, PR China.
authors.forename: Xiufeng
authors.initials: X
authors.lastname: Liu
authors.affiliation: College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, PR China. Electronic address: zhangrui@njfu.edu.cn.
authors.forename: Rui
authors.initials: R
authors.lastname: Zhang
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects; D001458:Bandages; D002176:Candida albicans / Q000187:drug effects; D048271:Chitosan; D004926:Escherichia coli / Q000187:drug effects; D057809:HEK293 Cells; D006801:Humans; D012837:Silver Sulfadiazine / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D048271:Chitosan; D012837:Silver Sulfadiazine
keywords: Antibacterial; Biocompatibility; Chitosan; Silver sulfadiazine