title: Unconventional Passerini Reaction toward α-Aminoxy-amides.
abstract: The Passerini multicomponent reaction (P-3CR) toward the one-step synthesis of α-aminoxy-amide, by employing for the first time a N-hydroxamic acid component, has been reported. The sonication-accelerated, catalyst-free, simple, fast, and highly efficient Passerini reaction is used for the synthesis of diverse α-aminoxy-amides. The reaction is compatible with a vast range of aldehydes, isocyanides, and N-hydroxamic acids such as N-hydroxysuccinimides and phthalimides. The generated Passerini products can be easily converted into several follow-up products.
authors.affiliation: Department of Drug Design, University of Groningen , Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.
authors.forename: Ajay L
authors.identifier: 0000-0001-8236-9626
authors.initials: AL
authors.lastname: Chandgude
authors.affiliation: Department of Drug Design, University of Groningen , Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.
authors.forename: Alexander
authors.identifier: 0000-0002-9923-8873
authors.initials: A
authors.lastname: Dömling
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D003486:Cyanides / Q000737:chemistry*; D006877:Hydroxamic Acids / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D000577:Amides; D003486:Cyanides; D006877:Hydroxamic Acids