title: Self-Assembling Molecular Capsules Based on α,γ-Cyclic Peptides.
abstract: A new capsule based on a β-sheet self-assembling cyclic peptide with the ability to recognize and release several guests is described. The host structure is composed of two self-complementary α,γ-cyclic peptides bearing a Zn porphyrin cap that is used for the selective recognition of the guest. The two components are linked through two dynamic covalent bonds. The combination of binding forces, including hydrogen bonding, metal coordination, and dynamic hydrazone bonds, allows the reversible recognition of long bipyridine guests. The affinity for these ligands showed a strong dependence on the guest length. Delivery of the encapsulated ligand can be achieved by hydrolysis of hydrazones to disrupt the sandwich complex structure.
authors.affiliation: Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS), and Departamento de Química Orgánica, Universidade de Santiago de Compostela , Santiago de Compostela 15782, Spain.
authors.forename: Haxel Lionel
authors.initials: HL
authors.lastname: Ozores
authors.affiliation: Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS), and Departamento de Química Orgánica, Universidade de Santiago de Compostela , Santiago de Compostela 15782, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Amorín
authors.affiliation: Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS), and Departamento de Química Orgánica, Universidade de Santiago de Compostela , Santiago de Compostela 15782, Spain.
authors.forename: Juan R
authors.identifier: 0000-0002-5842-7504
authors.initials: JR
authors.lastname: Granja
mesh_terms: D002214:Capsules / Q000737:chemistry*; D006835:Hydrazones / Q000737:chemistry; D006860:Hydrogen Bonding; D008024:Ligands; D010456:Peptides, Cyclic / Q000737:chemistry; D017433:Protein Structure, Secondary
chemical_list: D002214:Capsules; D006835:Hydrazones; D008024:Ligands; D010456:Peptides, Cyclic