title: Platelet-rich plasma: a biomimetic approach to enhancement of surgical wound healing.
abstract: Platelets are small anucleate cytoplasmic cell bodies released by megakaryocytes in response to various physiologic triggers. Traditionally thought to be solely involved in the mechanisms of hemostasis, platelets have gained much attention due to their involvement wound healing, immunomodulation, and antiseptic properties. As the field of surgery continues to evolve so does the need for therapies to aid in treating the increasingly complex patients seen. With over 14 million obstetric, musculoskeletal, and urological and gastrointestinal surgeries performed annually, the healing of surgical wounds continues to be of upmost importance to the surgeon and patient. Platelet-rich plasma, or platelet concentrate, has emerged as a possible adjuvant therapy to aid in the healing of surgical wounds and injuries. In this review, we will discuss the wound healing properties of platelet-rich plasma and various surgical applications.
authors.affiliation: Department of Surgery, Houston Methodist Hospital, Houston, Texas; Surgical Advanced Technologies Laboratory, Department of Biomimetic and Regenerative Medicine, Houston Methodist Research Institute, Houston, Texas. Electronic address: jsfernandez-moure@houstonmethodist.org.
authors.forename: Joseph S
authors.initials: JS
authors.lastname: Fernandez-Moure
authors.affiliation: Department of Surgery, Houston Methodist Hospital, Houston, Texas; Surgical Advanced Technologies Laboratory, Department of Biomimetic and Regenerative Medicine, Houston Methodist Research Institute, Houston, Texas.
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Van Eps
authors.affiliation: Surgical Advanced Technologies Laboratory, Department of Biomimetic and Regenerative Medicine, Houston Methodist Research Institute, Houston, Texas.
authors.forename: Fernando J
authors.initials: FJ
authors.lastname: Cabrera
authors.affiliation: Department of Surgery, Houston Methodist Hospital, Houston, Texas.
authors.forename: Zonia
authors.initials: Z
authors.lastname: Barbosa
authors.affiliation: Surgical Advanced Technologies Laboratory, Department of Biomimetic and Regenerative Medicine, Houston Methodist Research Institute, Houston, Texas.
authors.forename: Guillermo
authors.initials: G
authors.lastname: Medrano Del Rosal
authors.affiliation: Surgical Advanced Technologies Laboratory, Department of Biomimetic and Regenerative Medicine, Houston Methodist Research Institute, Houston, Texas; Department of Orthopedic Surgery, Houston Methodist Hospital, Houston, Texas.
authors.forename: Bradley K
authors.initials: BK
authors.lastname: Weiner
authors.affiliation: Department of Plastic and Reconstructive Surgery, Houston Methodist Hospital, Houston, Texas.
authors.forename: Warren A
authors.initials: WA
authors.lastname: Ellsworth
authors.affiliation: Surgical Advanced Technologies Laboratory, Department of Biomimetic and Regenerative Medicine, Houston Methodist Research Institute, Houston, Texas.
authors.forename: Ennio
authors.initials: E
authors.lastname: Tasciotti
mesh_terms: D032701:Biomimetics; D016913:Blood Component Transfusion; D001792:Blood Platelets / Q000502:physiology; D001804:Blood Transfusion, Autologous; D006801:Humans; D053657:Platelet-Rich Plasma; D000072836:Surgical Wound / Q000503:physiopathology / Q000628:therapy*; D014945:Wound Healing / Q000502:physiology*
keywords: Healing; Infection; Musculoskeletal; Neovascularization; Platelet-rich plasma; Wound