title: AVP1: One Protein, Many Roles.
abstract: Constitutive expression of the Arabidopsis vacuolar proton-pumping pyrophosphatase (H+-PPase) gene (AVP1) increases plant growth under various abiotic stress conditions and, importantly, under nonstressed conditions. Many interpretations have been proposed to explain these phenotypes, including greater vacuolar ion sequestration, increased auxin transport, enhanced heterotrophic growth, and increased transport of sucrose from source to sink tissues. In this review, we evaluate all the roles proposed for AVP1, using findings published to date from mutant plants lacking functional AVP1 and transgenic plants expressing AVP1. It is clear that AVP1 is one protein with many roles, and that one or more of these roles act to enhance plant growth. The complexity suggests that a systems biology approach to evaluate biological networks is required to investigate these intertwined roles.
authors.affiliation: School of Agriculture, Food and Wine, The University of Adelaide, Adelaide, SA 5005, Australia. Electronic address: rhiannon.schilling@adelaide.edu.au.
authors.forename: Rhiannon K
authors.initials: RK
authors.lastname: Schilling
authors.affiliation: Biological and Environmental Sciences and Engineering, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia.
authors.forename: Mark
authors.initials: M
authors.lastname: Tester
authors.affiliation: School of Agriculture, Food and Wine, The University of Adelaide, Adelaide, SA 5005, Australia.
authors.forename: Petra
authors.initials: P
authors.lastname: Marschner
authors.affiliation: School of Agriculture, Food and Wine, The University of Adelaide, Adelaide, SA 5005, Australia; Australian Centre for Plant Functional Genomics, Adelaide, SA 5005, Australia.
authors.forename: Darren C
authors.initials: DC
authors.lastname: Plett
authors.affiliation: School of Agriculture, Food and Wine, The University of Adelaide, Adelaide, SA 5005, Australia; Australian Centre for Plant Functional Genomics, Adelaide, SA 5005, Australia.
authors.forename: Stuart J
authors.initials: SJ
authors.lastname: Roy
mesh_terms: D011756:Diphosphates / Q000378:metabolism; D018506:Gene Expression Regulation, Plant; D043564:Inorganic Pyrophosphatase / Q000235:genetics / Q000378:metabolism; D010940:Plant Proteins / Q000235:genetics / Q000378:metabolism*; D013395:Sucrose / Q000378:metabolism; D014617:Vacuoles / Q000378:metabolism
chemical_list: D011756:Diphosphates; D010940:Plant Proteins; C107241:diphosphoric acid; D013395:Sucrose; D043564:Inorganic Pyrophosphatase
keywords: H(+)-pyrophosphatase; plant growth; pyrophosphate; sucrose; vacuole