title: Predictors of residual disease after unplanned excision of soft tissue sarcomas.
abstract: Unplanned excision of soft tissue sarcomas (STS) is an important quality of care issue given the morbidity related to tumor bed excision. Since not all patients harbor residual disease at the time of reexcision, we sought to determine predictors of residual STS following unplanned excision.
  
  
  
  We identified 76 patients from a prospective database (January 1, 2008-September 30, 2014) who received a diagnosis of primary STS following unplanned excision on the trunk or extremities. We used univariable and multivariable analyses to evaluate predictors of residual STS as the primary endpoint. We calculated the sensitivity, specificity, and accuracy of interval magnetic resonance imaging (MRI) to predict residual sarcoma at reexcision.
  
  
  
  Mean age was 52 y, and 63.2% were male. 50% had fragmented unplanned excision. Among patients undergoing reexcision, residual STS was identified in 70%. On univariable analysis, MRI showing gross disease and fragmented excision were significant predictors of residual STS (odds ratio, 10.59; 95% CI, 2.14-52.49; P = 0.004 and odds ratio, 3.61; 95% CI, 1.09-11.94; P = 0.035, respectively). On multivariable analysis, tumor size predicted distant recurrence and overall survival. When we combined equivocal and positive MRI, the sensitivity and specificity of MRI for predicting residual STS were 86.7% (95% CI, 73.2%-95.0%) and 57.9% (95% CI, 33.5%-79.8%), with an overall accuracy of 78.1% (95% CI, 66.0%-87.5%).
  
  
  
  About 70% of patients undergoing repeat excision after unplanned excision of STS harbor residual sarcoma. Although interval MRI and fragmented excision appear to be the most significant predictors of residual STS, the accuracy of MRI remains modest, especially given the incidence of equivocal MRI.
authors.affiliation: Division of Surgical Oncology, Department of Surgery, UC Davis School of Medicine, Sacramento, California.
authors.forename: Alicia A
authors.initials: AA
authors.lastname: Gingrich
authors.affiliation: Division of Surgical Oncology, Department of Surgery, UC Davis School of Medicine, Sacramento, California.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Elias
authors.affiliation: Division of Biostatistics, Department of Public Health Sciences, Arizona College of Osteopathic Medicine, Midwestern University, Glendale, Arizona.
authors.forename: Chia-Yuan
authors.initials: CY
authors.lastname: Michael Lee
authors.affiliation: Division of Surgical Oncology, Department of Surgery, UC Davis School of Medicine, Sacramento, California.
authors.forename: Yves-Paul N
authors.initials: YN
authors.lastname: Nakache
authors.affiliation: Division of Biostatistics, Department of Public Health Sciences, UC Davis, Davis, California.
authors.forename: Chin-Shang
authors.initials: CS
authors.lastname: Li
authors.affiliation: Division of Surgical Oncology, Department of Surgery, UC Davis School of Medicine, Sacramento, California.
authors.forename: Dhruvil R
authors.initials: DR
authors.lastname: Shah
authors.affiliation: Department of Radiology, UC Davis School of Medicine, Sacramento, California.
authors.forename: Robert D
authors.initials: RD
authors.lastname: Boutin
authors.affiliation: Division of Surgical Oncology, Department of Surgery, UC Davis School of Medicine, Sacramento, California. Electronic address: rjcanter@ucdavis.edu.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Canter
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D000072662:Margins of Excision; D008875:Middle Aged; D018365:Neoplasm, Residual; D016016:Proportional Hazards Models; D012509:Sarcoma / Q000000981:diagnostic imaging / Q000601:surgery*; D012983:Soft Tissue Neoplasms / Q000000981:diagnostic imaging / Q000601:surgery*; D055815:Young Adult
keywords: MRI; Residual disease; Soft tissue sarcoma; Unplanned excision