title: Risk of cytomegalovirus reactivation in patients with immune-mediated inflammatory diseases undergoing biologic treatment: a real matter?
abstract: The use of biological agents has grown exponentially in immune-mediated inflammatory diseases (IMID), often achieving a good control of disease progression and improving patients' quality of life. However, their use resulted in an increased risk of adverse events, including reactivation of chronic/latent infectious diseases. As for the risk of Cytomegalovirus (CMV) reactivation, very few data are available. We reviewed the literature reporting cases of CMV infection in IMID patients during biological therapy. Although the risk of CMV reactivation cannot be excluded, we concluded that there is no evidence to warrant CMV screening before starting a biological agent.
authors.affiliation: Infectious Diseases Unit, University of Florence. jessicamencarini@gmail.com.
authors.forename: J
authors.initials: J
authors.lastname: Mencarini
authors.forename: M
authors.initials: M
authors.lastname: Spinicci
authors.forename: F
authors.initials: F
authors.lastname: Bartalesi
mesh_terms: D001688:Biological Products / Q000009:adverse effects*; D003095:Collagen Diseases / Q000188:drug therapy / Q000276:immunology / Q000821:virology*; D003587:Cytomegalovirus / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000175:diagnosis* / Q000276:immunology / Q000821:virology; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D011379:Prognosis; D014775:Virus Activation / Q000276:immunology
chemical_list: D001688:Biological Products; D007166:Immunosuppressive Agents