title: The Relationship betweenMC1RMutation and Plumage Color Variation in Pigeons.
abstract: The polymorphisms ofMC1Rgene play a crucial role in coat color variation in mammals; however, the relationship is still unclear in pigeons. In this study, we sequenced 741 bp fragment of theMC1Rfor 39 individuals with five plumage color patterns (gray plumage,n= 12; black plumage,n= 9; white plumage,n= 3; spotted plumage,n= 12; red plumage,n= 3). A total of three single nucleotide polymorphisms (SNPs) were detected, including G199A, G225A, and A466G, which subsequently determined four haplotypes (H1-H4). Among them, H1 is the predominant haplotype. Association analysis revealed that H1 and H3 were significantly associated with the black plumage trait (P< 0.05), while the H4 was significantly associated with gray plumage trait (P< 0.05). Furthermore, only diplotype H1H1 was significantly associated with black and gray traits of pigeons. Collectively, our study suggested an association between genetic variation ofMC1Rand plumage color in pigeon.
authors.affiliation: Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu Campus, Chengdu 611130, China.
authors.forename: Jin-Shan
authors.initials: JS
authors.lastname: Ran
authors.affiliation: Chongqing Academy of Animal Science, Rongchang, Chongqing 402460, China.
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: You
authors.affiliation: Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu Campus, Chengdu 611130, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Jin
authors.affiliation: Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu Campus, Chengdu 611130, China.
authors.forename: Yu-Guang
authors.initials: YG
authors.lastname: Zhou
authors.affiliation: Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu Campus, Chengdu 611130, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu Campus, Chengdu 611130, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Lan
authors.affiliation: Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu Campus, Chengdu 611130, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Ren
authors.affiliation: Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu Campus, Chengdu 611130, China.
authors.forename: Yi-Ping
authors.identifier: 0000-0003-1477-9097
authors.initials: YP
authors.lastname: Liu
mesh_terms: D000818:Animals; D030161:Avian Proteins / Q000235:genetics*; D003116:Color; D010856:Columbidae / Q000235:genetics*; D056726:Genetic Association Studies; D006239:Haplotypes; D009154:Mutation; D010860:Pigments, Biological / Q000235:genetics*; D011110:Polymorphism, Genetic; D043562:Receptors, G-Protein-Coupled / Q000235:genetics*
chemical_list: D030161:Avian Proteins; D010860:Pigments, Biological; D043562:Receptors, G-Protein-Coupled