title: Acute phospholipid microspherule associated arthritis: Is it rare?
abstract: Joint fluid analysis must be performed as part of the diagnostic workup for acute arthritis, most notably to rule out septic arthritis and to allow the identification of crystal-induced arthritis (gout or calcium pyrophosphate deposition disease), which is one of the most common causes. However, the detection of monosodium urate or calcium pyrophosphate microcrystals is not the only goal of the polarized light microscopy examination of joint fluid. Other, less common microcrystals may be found. Among them are phospholipid microspherules, which are easily recognized microscopically based on their Maltese cross-like appearance. Phospholipid microspherules are a cause of acute arthritis that is often missed by rheumatologists and may therefore be more common than generally believed.
authors.affiliation: Service de Rhumatologie, CHU de Rennes, Hôpital Sud, 16, boulevard de Bulgarie, BP 90347, 35203 Rennes cedex 2, France; INSERM UMR 991, 35043 Rennes, France; Université Rennes 1, Faculté de médecine, 35043 Rennes, France. Electronic address: guillaume.coiffier@chu-rennes.fr.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Coiffier
authors.affiliation: Service de Rhumatologie, CHU de Rennes, Hôpital Sud, 16, boulevard de Bulgarie, BP 90347, 35203 Rennes cedex 2, France; INSERM UMR 991, 35043 Rennes, France; Université Rennes 1, Faculté de médecine, 35043 Rennes, France.
authors.forename: Jean-David
authors.initials: JD
authors.lastname: Albert
authors.affiliation: Service de Rhumatologie, CHU de Rennes, Hôpital Sud, 16, boulevard de Bulgarie, BP 90347, 35203 Rennes cedex 2, France; INSERM UMR 991, 35043 Rennes, France; Université Rennes 1, Faculté de médecine, 35043 Rennes, France.
authors.forename: François
authors.initials: F
authors.lastname: Robin
authors.affiliation: Service de Rhumatologie, CHU de Rennes, Hôpital Sud, 16, boulevard de Bulgarie, BP 90347, 35203 Rennes cedex 2, France; INSERM UMR 991, 35043 Rennes, France; Université Rennes 1, Faculté de médecine, 35043 Rennes, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Guggenbuhl
mesh_terms: D000208:Acute Disease; D001168:Arthritis / Q000175:diagnosis*; D015210:Arthritis, Gouty / Q000175:diagnosis*; D001170:Arthritis, Infectious / Q000175:diagnosis; D002130:Calcium Phosphates / Q000032:analysis*; D002805:Chondrocalcinosis / Q000175:diagnosis*; D003460:Crystallization; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008859:Microscopy, Polarization; D013582:Synovial Fluid / Q000737:chemistry*; D014527:Uric Acid / Q000032:analysis
chemical_list: D002130:Calcium Phosphates; D014527:Uric Acid; C020243:calcium phosphate
keywords: Acute arthritis; Maltese cross; Microcrystals; Microspherules; Phospholipids