title: Group B Streptococcal Toxic Shock Syndrome and covR/S Mutations Revisited.
abstract: Gene mutations in the virulence regulator CovR/S of group A Streptococcus play a substantial role in the pathogenesis of streptococcal toxic shock syndrome. We screened 25 group B Streptococcus (GBS) isolates obtained from patients with streptococcal toxic shock syndrome and found only 1 GBS clone harboring this kind of mutation.
authors.forename: Parham
authors.initials: P
authors.lastname: Sendi
authors.forename: Muad Abd
authors.initials: MA
authors.lastname: El Hay
authors.forename: Claudia M
authors.initials: CM
authors.lastname: Brandt
authors.forename: Barbara
authors.initials: B
authors.lastname: Spellerberg
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D005260:Female; D015964:Gene Expression Regulation, Bacterial; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D058885:Multilocus Sequence Typing; D009154:Mutation; D012097:Repressor Proteins / Q000235:genetics* / Q000378:metabolism; D012703:Serotyping; D012772:Shock, Septic / Q000382:microbiology* / Q000401:mortality / Q000473:pathology; D013290:Streptococcal Infections / Q000382:microbiology* / Q000401:mortality / Q000473:pathology; D013292:Streptococcus agalactiae / Q000145:classification / Q000235:genetics / Q000472:pathogenicity*; D016019:Survival Analysis; D014774:Virulence; D037521:Virulence Factors / Q000235:genetics* / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; C000619936:CovR protein, Streptococcus agalactiae; D012097:Repressor Proteins; D037521:Virulence Factors
keywords: STSS; bacteria; group B Streptococcus; streptococcal toxic shock syndrome; streptococci; toxic shock syndrome; two-component system