title: Asymmetric addition of α-branched cyclic ketones to allenamides catalyzed by a chiral phosphoric acid.
abstract: We describe the asymmetric addition of unactivated α-branched cyclic ketones to allenamides catalyzed by a chiral phosphoric acid, generating an all-carbon quaternary stereocenter with broad substrate scope and high enantioselectivity. The products are easily transformed into their corresponding 1,5- and 1,4-ketoaldehyde derivatives, which are both important building blocks in organic synthesis.
authors.affiliation: Department of Chemistry, University of California, Berkeley, California 94720, USA.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Chemistry, University of California, Berkeley, California 94720, USA.
authors.forename: F Dean
authors.initials: FD
authors.lastname: Toste