title: Anticancer Effect ofFerulago MughleaPeşmen (Apiaceae) on Cancer Cell Proliferation.
abstract: FerulagoW. Koch. (Apiaceae) genus is represented by approximately 50 taxa throughout the world.Ferulagospecies are known as "Çakşır" or "Çağşır" in Turkey and mostly known for their aphrodisiac effects. However recent reports emphasize the activity of variousFerulagospecies against cancer, as well. The aim of this study was to investigate the effect of lyophilized extract ofF. mughleaPeşmen, a species endemic for Turkey, on cancer cell proliferation. For this purpose human prostate (PC-3) and colorectal (SW-480) carcinoma cells were used to evaluate the antiproliferative effects of Ferulago W. Koch and the measurements were performed via MTT test. Lyophilized extracts obtained from aerial parts and the roots exhibited potent inhibitor effects on cell proliferation. Aerial part of the plant inhibited the proliferation of SW-480 cell at 48thhour with a 0.119 mg/mL IC50value.
authors.affiliation: Ankara University, Faculty of Pharmacy, Department of Biochemistry, 06100 Tandoğan, Ankara, Turkey.
authors.forename: Bakar
authors.initials: B
authors.lastname: Filiz
authors.affiliation: Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Botany, 06100 Tandoğan, Ankara, Turkey.
authors.forename: Karakay
authors.initials: K
authors.lastname: Songül
authors.affiliation: Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Botany, 06100 Tandoğan, Ankara, Turkey.
authors.forename: Delimustafaoğlu
authors.initials: D
authors.lastname: Bostanlık
authors.affiliation: Ankara University, Faculty of Pharmacy, Department of Biochemistry, 06100 Tandoğan, Ankara, Turkey.
authors.forename: Fatma
authors.initials: F
authors.lastname: Gül
authors.affiliation: Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Botany, 06100 Tandoğan, Ankara, Turkey.
authors.forename: Kılıç
authors.initials: K
authors.lastname: Ceyda Sibel
keywords: Apiaceae; Ferulago mughlea; antiproliferative; cancer; colorectal carcinoma; lyophilized extract; prostate