title: Repair of large segmental bone defects with fascial flap-wrapped allogeneic bone.
abstract: BACKGROUND
  The objective of this study was to investigate the therapeutic effects of the application of fascial flap-wrapped allogeneic bone for repair of large segmental tibial defects in rabbits and provide a theoretical basis for treatment of large segmental defects in weight-bearing bones.
  
  
  METHODS
  Forty-eight healthy adult New Zealand White (NZW) rabbits were randomized into two groups to establish 15-mm bone defects in the proximal tibia. Bone defects in test and control groups were repaired using allogeneic bone with and without a vascularized fascial flap from the rabbit proximal tibia, respectively. The differences in repair of bone defects between the two groups were assessed with postoperative X-ray examination, new bone quantity assessment, serum bone Gla protein (BGP) level, and biomechanical testing.
  
  
  RESULTS
  The therapeutic effect in the test group was superior to that in the control group.
  
  
  CONCLUSIONS
  Fascial flap-wrapped allogeneic bone is superior to allogeneic bone alone, and is ideal for the treatment of large segmental bone defects.
authors.affiliation: Department of Orthopaedics, Yidu Central Hospital Affiliated to Weifang Medical University, Weifang, 261000, Shandong Province, China.
authors.forename: Honglei
authors.initials: H
authors.lastname: Dou
authors.affiliation: Department of Orthopaedics, Yidu Central Hospital Affiliated to Weifang Medical University, Weifang, 261000, Shandong Province, China.
authors.forename: Guowei
authors.initials: G
authors.lastname: Wang
authors.affiliation: Department of Orthopaedics, Yidu Central Hospital Affiliated to Weifang Medical University, Weifang, 261000, Shandong Province, China.
authors.forename: Na
authors.initials: N
authors.lastname: Xing
authors.affiliation: Department of Anesthesiology, Qingdao Municipal Hospital, Qingdao, 266071, Shandong Province, China. hongleidou@126.com.
authors.forename: Lina
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000818:Animals; D005205:Fascia; D050723:Fractures, Bone / Q000000981:diagnostic imaging* / Q000601:surgery*; D011817:Rabbits; D011897:Random Allocation; D013524:Surgical Flaps; D013977:Tibia / Q000000981:diagnostic imaging* / Q000293:injuries / Q000601:surgery*; D014184:Transplantation, Homologous / Q000379:methods
keywords: Allogeneic bone; Bone defects; Fascial flap