title: Cued memory reconsolidation in rats requires nitric oxide.
abstract: It is well-known that the reactivation of consolidated fear memory under boundary conditions of novelty and protein synthesis blockade results in an impairment of memory, suggesting that the reactivated memory is destabilized and requires synthesis of new proteins for reconsolidation. We tested the hypothesis of nitric oxide (NO) involvement in memory destabilization during the reconsolidation process in rats using memory reactivation under different conditions. We report that administration of NO-synthase selective blockers 3-Br-7-NI or ARL in the conditions of reactivation of memory under a protein synthesis blockade prevented destabilization of fear memory to the conditioned stimulus. Obtained results support the role of NO signaling pathway in the destabilization of existing fear memory triggered by reactivation, and demonstrate that the disruption of this pathway during memory reconsolidation may prevent changes in long-term memory.
authors.affiliation: Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 5A Butlerova St., Moscow, 117485, Russia.
authors.forename: Natalia V
authors.initials: NV
authors.lastname: Bal
authors.affiliation: Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 5A Butlerova St., Moscow, 117485, Russia.
authors.forename: Mariia P
authors.initials: MP
authors.lastname: Rysakova
authors.affiliation: Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 5A Butlerova St., Moscow, 117485, Russia.
authors.forename: Alia Kh
authors.initials: AK
authors.lastname: Vinarskaya
authors.affiliation: Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 5A Butlerova St., Moscow, 117485, Russia.
authors.forename: Violetta
authors.initials: V
authors.lastname: Ivanova
authors.affiliation: Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 5A Butlerova St., Moscow, 117485, Russia.
authors.forename: Alena B
authors.initials: AB
authors.lastname: Zuzina
authors.affiliation: Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 5A Butlerova St., Moscow, 117485, Russia.
authors.forename: Pavel M
authors.identifier: 0000-0001-9248-8207
authors.initials: PM
authors.lastname: Balaban
mesh_terms: D000578:Amidines / Q000494:pharmacology; D000818:Animals; D003463:Cues; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005239:Fear; D007191:Indazoles / Q000494:pharmacology; D008297:Male; D000069077:Memory Consolidation / Q000187:drug effects*; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D051381:Rats; D017208:Rats, Wistar
chemical_list: C106731:3-bromo-7-nitroindazole; C102136:ARL 17477; D000578:Amidines; D004791:Enzyme Inhibitors; D007191:Indazoles; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase
keywords: labilization; memory; nitric oxide; protein synthesis; reactivation