title: Platelet Immunology in China: Research and Clinical Applications.
abstract: Immunization against human platelet alloantigens (HPAs) is associated with a number of clinical complications. The detection and identification of clinically relevant platelet antibodies are important for the diagnosis and management of patients affected with immune-mediated thrombocytopenias. Human platelet alloantigen frequencies and the characteristics of antiplatelet antibodies vary widely between ethnic groups. Since 2008, the importance of platelet immunology in the field of transfusion medicine has gained greater recognition by clinical laboratories in China. Laboratories in China have established and improved methods for platelet antibody detection and HPA genotyping techniques, which are used for the diagnosis of alloimmune platelet disorders in clinic and research environments. Research has revealed the frequencies of HPA alleles in different Chinese ethnic groups and compared the differences in HPA gene frequencies between the Chinese Han and other ethnic groups of the world. Production of anti-CD36 isoantibodies is an important risk factor for immune-mediated thrombocytopenia in the Chinese population. Advances in research and clinical application of platelet immunology have significantly improved the clinical diagnosis, treatment including transfusion support, and prevention of alloimmune platelet disorders in the Chinese population.
authors.affiliation: Nanning Institute of Transfusion Medicine, Nanning Blood Center, Nanning, China. Electronic address: guangwu@szonline.net.
authors.forename: Guoguang
authors.initials: G
authors.lastname: Wu
authors.affiliation: Nanning Institute of Transfusion Medicine, Nanning Blood Center, Nanning, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Nanning Institute of Transfusion Medicine, Nanning Blood Center, Nanning, China.
authors.forename: Lilan
authors.initials: L
authors.lastname: Li
authors.affiliation: Nanning Institute of Transfusion Medicine, Nanning Blood Center, Nanning, China.
authors.forename: Zhoulin
authors.initials: Z
authors.lastname: Zhong
authors.affiliation: Nanning Institute of Transfusion Medicine, Nanning Blood Center, Nanning, China.
authors.forename: Hengchong
authors.initials: H
authors.lastname: Li
authors.affiliation: Nanning Institute of Transfusion Medicine, Nanning Blood Center, Nanning, China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Li
authors.affiliation: Nanning Institute of Transfusion Medicine, Nanning Blood Center, Nanning, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Yu
authors.affiliation: Nanning Institute of Transfusion Medicine, Nanning Blood Center, Nanning, China.
authors.forename: Weidong
authors.initials: W
authors.lastname: Shen
authors.affiliation: Canadian Blood Services and Department of Laboratory Medicine and Pathobiology, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Heyu
authors.initials: H
authors.lastname: Ni
mesh_terms: D016824:Antigens, Human Platelet / Q000097:blood / Q000235:genetics / Q000276:immunology; D035843:Biomedical Research / Q000379:methods / Q000639:trends; D001792:Blood Platelets / Q000276:immunology*; D001803:Blood Transfusion; D002681:China; D006801:Humans; D011110:Polymorphism, Genetic; D064826:Transfusion Medicine / Q000379:methods / Q000639:trends; D065227:Transfusion Reaction / Q000097:blood / Q000235:genetics / Q000276:immunology; D014181:Transplantation Immunology
chemical_list: D016824:Antigens, Human Platelet
keywords: Anti-CD36; Chinese population; Human platelet alloantigens; Immune-mediated thrombocytopenia; Platelet immunology