title: Serum Levels of IL-10 and IL-22 Cytokines in Patients with Psoriasis.
abstract: BACKGROUND
  As a chronic inflammatory condition, psoriasis results from an interaction between genetic and immunologic factors in a predisposing environment. In spite of compelling evidence for the role of T cells and cytokines in psoriasis, interleukin (IL)-10 and IL-22 have not been sufficiently investigated.
  
  
  OBJECTIVE
  To assess the serum levels of IL-10 and IL-22 in patients with psoriasis compared to healthy controls.
  
  
  METHODS
  A total of 28 patients with psoriasis were compared with 28 age and sex-matched healthy subjects. Psoriasis Area and Severity Index (PASI) criteria were used to measure the severity of the disease. Serum levels of IL-10 and IL-22 were measured in both groups and compared.
  
  
  RESULTS
  The mean serum level of IL-10 was 89.5±18.7 in patients compared to 117.2±23.4 pg/ml in the controls (p=0.36). Also, serum level of IL-22 was 284.1±49.7 in patients versus 425.4±82.8 pg/ml in control group (p=0.17). There was a significant direct correlation between levels of IL-10 and IL-22 in patients group (p=0.0005). The clinical severity of psoriasis was significantly correlated with high levels of IL-22 (p<0.0001).
  
  
  CONCLUSIONS
  The direct correlation between higher levels of IL-22 and disease severity supports the clinical implication of this cytokine in psoriasis.
authors.affiliation: Psoriasis Research Center, Department of Dermatology, Farshchian Hospital, Hamadan University of Medical Sciences, Hamadan, Iran.
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Sobhan
authors.forename: Mahmood
authors.initials: M
authors.lastname: Farshchian
authors.forename: Ali
authors.initials: A
authors.lastname: Hoseinzadeh
authors.forename: Hamid Reza
authors.initials: HR
authors.lastname: Ghasemibasir
authors.forename: Ghasem
authors.initials: G
authors.lastname: Solgi
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000097:blood*; D007378:Interleukins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000097:blood* / Q000175:diagnosis; D012720:Severity of Illness Index; D000097043:Interleukin-22
chemical_list: D016753:Interleukin-10; D007378:Interleukins; D000097043:Interleukin-22