title: Laparoscopic Treatment of Adrenal Tumors: A Single-Center Experience with 58 Patients.
abstract: Background.The aim of this study is to discuss the laparoscopic approach and assess the immunohistochemical expression profiles of synaptophysin, Ki-67, and inhibin and patient outcomes in adrenal masses through a series of cases treated at our institution.Method.The study was conducted on 58 patients who were diagnosed with adrenal masses. All cases were operated on laparoscopically for adrenal masses.Results.Both inhibin and synaptophysin were found positive in 45 patients (77,6%). Ki-67 was negative in 11 patients, whereas it was found positive in 42 with a rate of 1%. The size of the masses ranged from 1 up to 9 cm (mean 4,3 ± 1,5). Urine hormone excretion was measured within normal ranges in 47 out of 58 patients (81%). Most of the diagnosed patients were harboring Cortical Adenoma (n: 38; 65,5%). All of the masses were successfully resected without complication except 3 patients. Because of complications of bleeding, the operation was converted to open surgery for 2 patients.Conclusion.Morbidity, mortality, and healing were comparable, regardless of tumor size, yet involvement in both laparoscopic and adrenal surgery was required. Our results suggested that laparoscopic adrenalectomy should replace open surgery as the standard treatment for most adrenal masses.
authors.affiliation: Department of General Surgery, Istanbul Education and Research Hospital, Istanbul, Turkey.
authors.forename: Aziz
authors.identifier: 0000-0002-7806-2354
authors.initials: A
authors.lastname: Ari
authors.affiliation: Department of General Surgery, Istanbul Education and Research Hospital, Istanbul, Turkey.
authors.forename: Kenan
authors.identifier: 0000-0002-3449-1974
authors.initials: K
authors.lastname: Buyukasik
authors.affiliation: Department of General Surgery, Istanbul Education and Research Hospital, Istanbul, Turkey.
authors.forename: Cihad
authors.identifier: 0000-0002-0407-9655
authors.initials: C
authors.lastname: Tatar
authors.affiliation: Department of General Surgery, Istanbul Education and Research Hospital, Istanbul, Turkey.
authors.forename: Ozgur
authors.initials: O
authors.lastname: Segmen
authors.affiliation: Department of General Surgery, Istanbul Education and Research Hospital, Istanbul, Turkey.
authors.forename: Feyzullah
authors.initials: F
authors.lastname: Ersoz
authors.affiliation: Department of General Surgery, Istanbul Education and Research Hospital, Istanbul, Turkey.
authors.forename: Soykan
authors.initials: S
authors.lastname: Arikan
authors.affiliation: Department of Pathology, Istanbul Education and Research Hospital, Istanbul, Turkey.
authors.forename: Feray
authors.initials: F
authors.lastname: Gunver
authors.affiliation: Department of General Surgery, Istanbul Education and Research Hospital, Istanbul, Turkey.
authors.forename: Serkan
authors.identifier: 0000-0003-2918-1776
authors.initials: S
authors.lastname: Sari