title: Innovative application of metal-organic frameworks for encapsulation and controlled release of allyl isothiocyanate.
abstract: This research investigated the technical feasibility of metal-organic frameworks (MOFs) as novel delivery systems for encapsulation and controlled release of volatile allyl isothiocyanate (AITC) molecules. We hypothesized that water vapor molecules could act as an external stimulus to trigger the release of AITC molecules encapsulated in MOFs. To test this hypothesis, three MOFs-HKUST-1, MOF-74(Zn), and RPM6-Zn-were selected based on their structural properties and AITC molecular characteristics. Results from adsorption-desorption and GC headspace analyses showed that these MOFs could encapsulate and retain AITC molecules within their pores under low (30-35%) relative humidity (RH) conditions. In contrast, the release of AITC molecules from all these MOFs was triggered under high RH (95-100%) conditions. These findings along with results from SEM, TEM, and XRPD studies support our hypothesis that water vapors could trigger the AITC release from these MOFs, indicating that development of the AITC-MOFs delivering system is technically feasible.
authors.affiliation: Department of Food Science, Rutgers University, 65 Dudley Road, New Brunswick, NJ 08901, USA. Electronic address: elham.lashkari@rutgers.edu.
authors.forename: Elham
authors.initials: E
authors.lastname: Lashkari
authors.affiliation: Department of Chemistry and Chemical Biology, Rutgers University, 610 Taylor Road, Piscataway, NJ 08854, USA. Electronic address: hao.wang@rutgers.edu.
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.affiliation: Eastern Regional Research Center, Agricultural Research Service, US Department of Agriculture, Wyndmoor, PA 19038, USA. Electronic address: linshu.liu@ars.usda.gov.
authors.forename: Linshu
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Chemistry and Chemical Biology, Rutgers University, 610 Taylor Road, Piscataway, NJ 08854, USA. Electronic address: Jingli@chem.rutgers.edu.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Food Science, Rutgers University, 65 Dudley Road, New Brunswick, NJ 08901, USA. Electronic address: kyam@sebs.rutgers.edu.
authors.forename: Kit
authors.initials: K
authors.lastname: Yam
mesh_terms: D000327:Adsorption; D003692:Delayed-Action Preparations / Q000737:chemistry*; D017879:Isothiocyanates / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*
chemical_list: D003692:Delayed-Action Preparations; D017879:Isothiocyanates; D009942:Organometallic Compounds; C004471:allyl isothiocyanate
keywords: Allyl isothiocyanate; Antimicrobial food packaging; Controlled release; Encapsulation; Metal-organic framework (MOF); Moisture-trigger; Natural food preservative