title: [Association between tumor necrosis factor-α G-308A polymorphisms and genetic susceptibility to spontaneous preterm birth].
abstract: OBJECTIVE
  To study the association between tumor necrosis factor-α (TNF-α) G-308A polymorphisms and genetic susceptibility to spontaneous preterm birth (SPTB).
  
  
  METHODS
  The case group enrolled 753 SPTB infants and the control group included 681 term infants. TNF-α G-308A polymorphisms were genotyped using Sequenom MassARRAY®SNP.
  
  
  RESULTS
  The frequencies of the allele (G and A) in the case and control groups were not significantly different (P=0.35). The frequencies of the genotypes (GG, GA and AA) in the case and control groups were not significantly different (P=0.64). The logistic regression analysis found that TNF-α G-308A was not associated with genetic susceptibility to SPTB (OR=0.85; 95%CI: 0.61-1.19; P=0.35).
  
  
  CONCLUSIONS
  There is no association between the polymorphisms of TNF-α G-308A and the genetic susceptibility to SPTB.
authors.affiliation: Bayi Children's Hospital Affiliated to Chinese People's Liberation Army General Hospital, Beijing 100700, China. 001wangyan@sina.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Peng
authors.forename: Xiao
authors.initials: X
authors.lastname: Yang
authors.forename: Li-Na
authors.initials: LN
authors.lastname: Zhu
authors.forename: Xiao-Ai
authors.initials: XA
authors.lastname: Zhang
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
mesh_terms: D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D020641:Polymorphism, Single Nucleotide; D047928:Premature Birth / Q000235:genetics*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D014409:Tumor Necrosis Factor-alpha