title: Stressing Out About RAD52.
abstract: The role of mammalian RAD52 has been mysterious due to the lack of a strong DNA repair phenotype of RAD52-deficient cells. In this issue of Molecular Cell, studies by Bhowmick et al. (2016) and Sotiriou et al. (2016) reveal an unexpected role for RAD52 in promoting DNA synthesis following replication stress.
authors.affiliation: Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY 10032, USA. Electronic address: ac3685@cumc.columbia.edu.
authors.forename: Alberto
authors.initials: A
authors.lastname: Ciccia
authors.affiliation: Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA. Electronic address: lss5@cumc.columbia.edu.
authors.forename: Lorraine S
authors.initials: LS
authors.lastname: Symington
mesh_terms: D000818:Animals; D004260:DNA Repair; D004261:DNA Replication; D004268:DNA-Binding Proteins / Q000235:genetics; D006801:Humans; D051135:Rad51 Recombinase / Q000235:genetics; D051721:Rad52 DNA Repair and Recombination Protein / Q000235:genetics*; D011995:Recombination, Genetic; D012441:Saccharomyces cerevisiae / Q000235:genetics; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics
chemical_list: D004268:DNA-Binding Proteins; D051721:Rad52 DNA Repair and Recombination Protein; D029701:Saccharomyces cerevisiae Proteins; D051135:Rad51 Recombinase