title: Guidelines of the French Society of Otorhinolaryngology (SFORL) (short version). Specific treatment of epistaxis in Rendu-Osler-Weber disease.
abstract: OBJECTIVE
  The authors present the guidelines of the French Oto-Rhino-Laryngology - Head and Neck Surgery Society (Société Française d'Oto-Rhino-Laryngologie et de Chirurgie de la Face et du Cou: SFORL) concerning specific treatment of epistaxis in Rendu-Osler-Weber disease.
  
  
  METHODS
  A multidisciplinary work-group was entrusted with a review of the scientific literature on the above topic. Guidelines were drawn up, based on the articles retrieved and the group members' individual experience. They were then read over by an editorial group independent of the work group. The final version was established in a coordination meeting. The guidelines were graded as A, B, C or expert opinion, by decreasing level of evidence.
  
  
  RESULTS
  Rendu-Osler-Weber disease is diagnosed from the presence of at least three of Curaçao's four criteria. In acute epistaxis, bidigital compression is recommended. Embolization is reserved for resistant epistaxis. Non-resorbable nasal packing and cauterization are contraindicated. Patient education is essential. Telangiectasia of the nasal mucosa can be treated by various local means. In the event of insufficient control, systemic administration of tranexamic acid is recommended.
authors.affiliation: Service d'ORL, CHU de Caen, Avenue de la Côte-de-Nacre, 14003 Caen, France. Electronic address: robard-l@chu-caen.fr.
authors.forename: L
authors.initials: L
authors.lastname: Robard
authors.affiliation: Service ORL, Hôpital de la Conception, CHU de Marseille, 147, Boulevard Baille, 13005 Marseille, France.
authors.forename: J
authors.initials: J
authors.lastname: Michel
authors.affiliation: Service ORL, CHIC de Créteil, 40, Avenue de Verdun, 94000 Créteil, France.
authors.forename: V
authors.initials: V
authors.lastname: Prulière Escabasse
authors.affiliation: Service ORL, CHIC de Créteil, 40, Avenue de Verdun, 94000 Créteil, France.
authors.forename: E
authors.initials: E
authors.lastname: Bequignon
authors.affiliation: Service ORL, Hôpital Lariboisière, AP-HP, Université Paris 7, 2, Rue Ambroise-Paré, 75475 Paris Cedex 10, France.
authors.forename: B
authors.initials: B
authors.lastname: Vérillaud
authors.affiliation: Service ORL, CHU de Nantes, 44000 Nantes, France.
authors.forename: O
authors.initials: O
authors.lastname: Malard
authors.affiliation: Service ORL, CHU de Montpellier, 191, Avenue du Doyen Gaston Giraud, 34295 Montpellier cedex 5, France.
authors.forename: L
authors.initials: L
authors.lastname: Crampette
mesh_terms: D000933:Antifibrinolytic Agents / Q000627:therapeutic use; D017115:Catheter Ablation; D004844:Epistaxis / Q000209:etiology* / Q000628:therapy*; D006489:Hemostatic Techniques; D006490:Hemostatics / Q000627:therapeutic use; D006801:Humans; D053685:Laser Therapy; D010353:Patient Education as Topic; D013683:Telangiectasia, Hereditary Hemorrhagic / Q000150:complications / Q000175:diagnosis*; D014148:Tranexamic Acid / Q000627:therapeutic use
chemical_list: D000933:Antifibrinolytic Agents; D006490:Hemostatics; D014148:Tranexamic Acid
keywords: Anemia; Epistaxis; Reference center; Rendu-Osler-Weber disease