title: Deoxyschizandrin suppresses dss-induced ulcerative colitis in mice.
abstract: OBJECTIVE
  Deoxyschizandrin as one of the most important component of Schisandra chinensis (Turcz.) Baill plays an immunomodulatory role in a variety of diseases, yet its role in ulcerative colitis remains to be elucidated. We aimed to investigate the role of deoxyschizandrin in DSS-induced ulcerative colitis in mice.
  
  
  METHODS
  In the present study, an inflammation model of cells was constructed to confirm the anti-inflammatory effect of deoxyschizandrin. Then a mouse model with Dextran sulfate sodium sulfate (DSS)-induced ulcerative colitis was constructed, and the effects of deoxyschizandrin on mouse colon inflammation, apoptosis, and CD4 T lymphocyte infiltration in ulcerative colitis were examined.
  
  
  RESULTS
  Deoxyschizandrin could improve the symptoms of ulcerative colitis, determined by hematoxylin-eosin (HE) staining and histopathological scores. Moreover, deoxyschizandrin reduced the levels of inflammatory cytokines, suppressed CD4 T cell infiltration, and effectively inhibited apoptosis in the colon of DSS-induced ulcerative colitis mice.
  
  
  CONCLUSIONS
  In summary, deoxyschizandrin can effectively rescue the symptoms of DSS-induced ulcerative colitis in mice by inhibiting inflammation. T cell infiltration and apoptosis in the colon, suggesting that deoxyschizandrin could be a potential drug in treating ulcerative colitis.
authors.affiliation: Changchun University of Chinese Medicine, Changchun Jingyue Street, Boshuo Road 1035, Changchun, Jilin, China.
authors.forename: Wen-Feng
authors.initials: WF
authors.lastname: Zhang
authors.affiliation: Changchun University of Chinese Medicine, Changchun Jingyue Street, Boshuo Road 1035, Changchun, Jilin, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Changchun University of Chinese Medicine, Changchun Jingyue Street, Boshuo Road 1035, Changchun, Jilin, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Su
authors.affiliation: Changchun University of Chinese Medicine, Changchun Jingyue Street, Boshuo Road 1035, Changchun, Jilin, China.
authors.forename: Da-Yan
authors.initials: DY
authors.lastname: Xu
authors.affiliation: Changchun University of Chinese Medicine, Changchun Jingyue Street, Boshuo Road 1035, Changchun, Jilin, China.
authors.forename: Yu-Li
authors.initials: YL
authors.lastname: Yan
authors.affiliation: Changchun University of Chinese Medicine, Changchun Jingyue Street, Boshuo Road 1035, Changchun, Jilin, China.
authors.forename: Qiao
authors.initials: Q
authors.lastname: Gao
authors.affiliation: Changchun University of Chinese Medicine, Changchun Jingyue Street, Boshuo Road 1035, Changchun, Jilin, China.
authors.forename: Ming-Hua
authors.initials: MH
authors.lastname: Duan
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects*; D002460:Cell Line; D003093:Colitis, Ulcerative / Q000139:chemically induced / Q000188:drug therapy* / Q000276:immunology; D034242:Cyclooctanes / Q000008:administration & dosage* / Q000494:pharmacology; D016207:Cytokines / Q000378:metabolism; D016264:Dextran Sulfate / Q000009:adverse effects*; D004195:Disease Models, Animal; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects; D007249:Inflammation / Q000276:immunology; D017705:Lignans / Q000008:administration & dosage* / Q000494:pharmacology; D051379:Mice; D008810:Mice, Inbred C57BL; D011083:Polycyclic Compounds / Q000008:administration & dosage* / Q000494:pharmacology
chemical_list: D000893:Anti-Inflammatory Agents; D034242:Cyclooctanes; D016207:Cytokines; D017705:Lignans; D011083:Polycyclic Compounds; C034734:schizandrin A; D016264:Dextran Sulfate