title: Neuroprotective effect of sevoflurane in general anaesthesia.
abstract: OBJECTIVE
  The aim of this study was to evaluate the brain damage caused by inhaled sevoflurane, by determining the concentration of serum S100B protein before and after the exposure to this drug as the only anaesthetic agent.
  
  
  METHODS
  Paediatric patients undergoing general anaesthesia for the conduct of a nuclear magnetic resonance were included in the study. A venous blood sample was taken from each patient before (basal sample) and after (post-exposure sample) administering the general anaesthesia. The concentration of serum S100B protein was determined in the basal (S100Bb) and post-exposure sample (S100Bp).
  
  
  RESULTS
  A total of 72 patients were included in the study, with a mean patient age of 2 to 13 years (median=6), 28 males and 44 females. S100Bp values (median=66.5ng/L) were significantly lower (P=.0059) than those of S100Bb (median=84.0ng/L). The median of the difference between S100Bp and S100Bb was -11.0ng/L.
  
  
  CONCLUSIONS
  Inhaled sevoflurane at low doses causes a decrease of serum S100B protein levels, hence, this drug could have a neuroprotective effect in the central nervous system.
authors.affiliation: Unidad de Gestión Clínica de Pediatría, Hospital de Jerez de la Frontera, Jerez de la Frontera, Cádiz, España.
authors.forename: Victoria
authors.initials: V
authors.lastname: Ramos Ramos
authors.affiliation: Unidad de Gestión Clínica de Anestesiología, Hospital Universitario Puerto Real, Puerto Real, Cádiz, España.
authors.forename: Pablo
authors.initials: P
authors.lastname: Mesa Suárez
authors.affiliation: Unidad de Gestión Clínica de Laboratorio, Hospital Universitario Puerto Real, Puerto Real, Cádiz, España; Departamento de Biomedicina, Biotecnología y Salud Pública, Universidad de Cádiz, Cádiz, España. Electronic address: jdsantotoribioc@gmail.com.
authors.forename: José Diego
authors.initials: JD
authors.lastname: Santotoribio
authors.affiliation: Unidad de Gestión Clínica de Análisis Clínicos, Hospital de Jerez de la Frontera, Jerez de la Frontera, Cádiz, España.
authors.forename: María Ángela
authors.initials: MÁ
authors.lastname: González García
authors.affiliation: Departamento de Pediatría, Universidad de Granada, Granada, España.
authors.forename: Antonio
authors.initials: A
authors.lastname: Muñoz Hoyos
mesh_terms: D000293:Adolescent; D000768:Anesthesia, General / Q000009:adverse effects* / Q000379:methods; D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D015415:Biomarkers / Q000097:blood; D001930:Brain Injuries / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis / Q000517:prevention & control; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D008738:Methyl Ethers / Q000494:pharmacology*; D018696:Neuroprotective Agents / Q000494:pharmacology*; D064568:S100 Calcium Binding Protein beta Subunit / Q000097:blood*; D000077149:Sevoflurane
chemical_list: D018685:Anesthetics, Inhalation; D015415:Biomarkers; D008738:Methyl Ethers; D018696:Neuroprotective Agents; D064568:S100 Calcium Binding Protein beta Subunit; C579160:S100B protein, human; D000077149:Sevoflurane
keywords: Anestesia general; Brain damage; Daño cerebral; General anaesthesia; Proteína S100B; S100B protein; Sevoflurane; Sevoflurano