title: Increase in circulating sphingosine-1-phosphate and decrease in ceramide levels in psoriatic patients.
abstract: Psoriasis is characterized by hyperproliferation, deregulated differentiation and impaired apoptosis of keratinocytes. Mechanisms of lipid profile disturbances and metabolic syndrome in the psoriatic patients are still not fully understood. Sphingolipids, namely ceramides (CER) and sphingosine-1-phosphate (S1P) are signal molecules which can regulate cell growth, apoptosis and immune reactions. The aim of the study was to evaluate circulating CER and S1P levels in plaque-type psoriasis and their associations with the disease activity, inflammatory or metabolic markers and the presence of psoriatic comorbidities. Eighty-five patients with exacerbated plaque-type psoriasis and thirty-two healthy controls were enrolled. Serum CER and S1P concentrations before the treatment were examined. General patient characteristics included: PASI (Psoriasis Area and Severity Index), BMI (Body Mass Index), inflammatory and biochemical markers, lipid profile and presence of psoriatic comorbidities. Total serum concentration of CER was significantly decreased (p = 0.02) and concomitantly S1P levels significantly increased (p = 0.002) in psoriatic patients compared to the healthy control group. Among patients with psoriasis no significant correlations with the disease activity and inflammation markers were observed and only patients with psoriatic arthritis had significantly higher CER total concentration. Serum sphingolipid disturbances in psoriatic patients were observed. Decreased total CER and increased S1P serum levels may reflect their epidermal altered composition and metabolism. Patients with psoriatic arthritis have higher CER levels than psoriasis with skin involvement only. It might provide additional predictive value for psoriatic arthritis and may convey higher risk of metabolic and cardiovascular disease development in this group of patients.
authors.affiliation: Department of Dermatology and Venereology, Medical University of Bialystok, Żurawia Str. 14, 15-540, Bialystok, Poland. hanna.mysliwiec@gmail.com.
authors.forename: Hanna
authors.initials: H
authors.lastname: Myśliwiec
authors.affiliation: Department of Dermatology and Venereology, Medical University of Bialystok, Żurawia Str. 14, 15-540, Bialystok, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Baran
authors.affiliation: Department of Physiology, Medical University of Bialystok, Bialystok, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Harasim-Symbor
authors.affiliation: I Department of General and Endocrinological Surgery, Medical University of Bialystok, Bialystok, Poland.
authors.forename: Barbara
authors.initials: B
authors.lastname: Choromańska
authors.affiliation: I Department of General and Endocrinological Surgery, Medical University of Bialystok, Bialystok, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Myśliwiec
authors.affiliation: Department of Statistics and Medical Informatics, Medical University of Bialystok, Bialystok, Poland.
authors.forename: Anna Justyna
authors.initials: AJ
authors.lastname: Milewska
authors.affiliation: Department of Physiology, Medical University of Bialystok, Bialystok, Poland.
authors.forename: Adrian
authors.initials: A
authors.lastname: Chabowski
authors.affiliation: Department of Dermatology and Venereology, Medical University of Bialystok, Żurawia Str. 14, 15-540, Bialystok, Poland.
authors.forename: Iwona
authors.initials: I
authors.lastname: Flisiak
mesh_terms: D000328:Adult; D000368:Aged; D015535:Arthritis, Psoriatic / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002518:Ceramides / Q000097:blood*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000473:pathology; D008246:Lysophospholipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000097:blood; D055815:Young Adult
chemical_list: D015415:Biomarkers; D002518:Ceramides; D008246:Lysophospholipids; C060506:sphingosine 1-phosphate; D013110:Sphingosine
keywords: Ceramide; Psoriasis; Psoriatic arthritis; Sphingolipids; Sphingosine-1-phosphate