title: Comparing the vascular response in implantation of self-expanding, bare metal nitinol stents or paclitaxel-eluting nitinol stents in superficial femoral artery lesions: a serial optical frequency domain imaging study.
abstract: OBJECTIVE
  This study sought to investigate differences in vascular response between self-expanding bare metal nitinol stents (BMS) and paclitaxel-eluting nitinol stents (PES), in superficial femoral artery (SFA) disease, using optical frequency domain imaging (OFDI).
  
  
  RESULTS
  Six months after stent implantation, follow-up quantitative vascular angiography (QVA) and OFDI assessment were scheduled to evaluate vascular response. Volume index (VI) was defined as volume divided by stent length. The primary endpoint was OFDI-derived late lumen area loss, defined as lumen VI post stent implantation minus lumen VI at follow-up. A total of 28 SFA lesions were analysed, with cases randomised to receive either BMS or PES implantation. QVA-derived diameter stenosis at six-month follow-up was lower in the PES group than in the BMS group (28.5% vs. 39.7%, p=0.04). After six months, BMS VI increased by 33.8% (20.7±3.7 to 27.7±3.5 mm3/mm), whilst PES exhibited an increase of 32.1% (19.0±2.3 to 25.1±4.7 mm3/mm). Neointimal VI was smaller (7.4±2.6 mm3/mm vs. 10.5±3.2 mm3/mm, p<0.01) and late lumen area loss was lower (2.9±1.3 mm3/mm vs. 5.6±2.8 mm3/mm, p<0.01) in the PES group.
  
  
  CONCLUSIONS
  Serial volumetric OFDI analyses confirmed significantly smaller amounts of neointimal tissue and lower late lumen area loss following PES implantation for SFA lesions at short-term follow-up.
authors.affiliation: Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.
authors.forename: Kojiro
authors.initials: K
authors.lastname: Miki
authors.forename: Kenichi
authors.initials: K
authors.lastname: Fujii
authors.forename: Masahiko
authors.initials: M
authors.lastname: Shibuya
authors.forename: Masashi
authors.initials: M
authors.lastname: Fukunaga
authors.forename: Takahiro
authors.initials: T
authors.lastname: Imanaka
authors.forename: Hiroto
authors.initials: H
authors.lastname: Tamaru
authors.forename: Machiko
authors.initials: M
authors.lastname: Nishimura
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Horimatsu
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Honda
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Fitzgerald
authors.forename: Tohru
authors.initials: T
authors.lastname: Masuyama
authors.forename: Masaharu
authors.initials: M
authors.lastname: Ishihara
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000497:Alloys / Q000627:therapeutic use*; D054855:Drug-Eluting Stents; D005260:Female; D005263:Femoral Artery / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D058426:Neointima / Q000175:diagnosis / Q000601:surgery*; D061848:Optical Imaging / Q000379:methods; D017239:Paclitaxel / Q000627:therapeutic use*; D018084:Ultrasonography, Interventional / Q000379:methods
chemical_list: D000497:Alloys; C013616:nitinol; D017239:Paclitaxel