title: HIV Latency TORn Down.
abstract: Combination therapy for HIV infection is effective at controlling disease but fails to eradicate the virus because a persistent reservoir of cells harbors latent HIV DNA. In this issue of Cell Host & Microbe, Besnard et al. (2016) show that the mTOR kinase is essential to reactivate HIV from latency.
authors.affiliation: Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), 34149 Trieste, Italy; Department of Medical, Surgical and Health Sciences, University of Trieste, 34127 Trieste, Italy. Electronic address: giacca@icgeb.org.
authors.forename: Mauro
authors.initials: M
authors.lastname: Giacca
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics / Q000378:metabolism; D015496:CD4-Positive T-Lymphocytes / Q000821:virology; D002352:Carrier Proteins / Q000378:metabolism; D004279:DNA, Viral; D015967:Gene Expression Regulation, Viral; D055785:Gene Knockdown Techniques; D015658:HIV Infections / Q000628:therapy* / Q000821:virology; D015497:HIV-1 / Q000235:genetics / Q000502:physiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D034741:RNA, Small Interfering; D000076226:Rapamycin-Insensitive Companion of mTOR Protein; D000076223:Regulatory-Associated Protein of mTOR; D058570:TOR Serine-Threonine Kinases / Q000187:drug effects / Q000378:metabolism*; D014775:Virus Activation; D017735:Virus Latency / Q000502:physiology*; D014779:Virus Replication; D000076242:mTOR Associated Protein, LST8 Homolog; D054322:tat Gene Products, Human Immunodeficiency Virus
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; D004279:DNA, Viral; C555285:MLST8 protein, human; C492571:RICTOR protein, human; D034741:RNA, Small Interfering; C463659:RPTOR protein, human; D000076226:Rapamycin-Insensitive Companion of mTOR Protein; D000076223:Regulatory-Associated Protein of mTOR; D000076242:mTOR Associated Protein, LST8 Homolog; D054322:tat Gene Products, Human Immunodeficiency Virus; C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases
keywords: HIV; latency; mTOR; therapy