title: Serine Metabolism Links Tumor Suppression to the Epigenetic Landscape.
abstract: Intermediary metabolism provides substrates that shape epigenetic status, but whether this interaction can be responsible for oncogenesis is largely unknown. In a recent issue of Nature, Kottakis et al. (2016) now show that the common tumor suppressor gene LKB1 can function by mediating this connection through an LKB1/AMPK/mTOR signaling axis.
authors.affiliation: Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.
authors.forename: Xia
authors.initials: X
authors.lastname: Gao
authors.affiliation: Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA. Electronic address: jason.locasale@duke.edu.
authors.forename: Jason W
authors.initials: JW
authors.lastname: Locasale
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000235:genetics*; D006801:Humans; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D012694:Serine; D015398:Signal Transduction
chemical_list: D012694:Serine; D017346:Protein Serine-Threonine Kinases; D055372:AMP-Activated Protein Kinases
keywords: AMPK; LKB1; epigenetics; mTOR; methylation; one-carbon metabolism; pancreas cancer; pancreatic cancer; serine