title: Monoterpenoids from the traditional North Italian vegetable Aruncus dioicus (Walter) Fernald var. vulgaris (Maxim.) H.Hara (Rosaceae).
abstract: Investigations of young shoots of Aruncus dioicus (Walter) Fernald var. vulgaris (Maxim.) H.Hara (Rosaceae), collected from the wild and used as vegetables in alpine provinces of Italy, yielded eight monoterpenoids. Besides known compounds, aruncin A, aruncide A, and cimicifugolide, five previously undescribed substances, aruncins C, D, and E, and aruncides D and E, were identified. Based on results from the full synthesis of aruncin B, structures of aruncin A and aruncide A were revised. Structures were established by HR mass spectrometry and extensive 1D and 2D NMR spectroscopy and based on data from synthetic aruncin B. An HPLC-DAD-ESI-MS method was developed to investigate the distribution of the monoterpenoids in different organs of Aruncus dioicus var. vulgaris and in aerial parts of A. dioicus var. aethusifolius (H.Lév.) H.Hara [Syn.: Aruncus aethusifolius (H.Lév.) Nakai]. Preliminary bioactivity studies moreover indicated weak cytotoxicity for some of the compounds against human prostrate adenocarcinoma cells.
authors.affiliation: Department of Pharmacognosy and Molecular Basis of Phytotherapy, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Granica
authors.affiliation: Consiglio per la Ricerca in Agricoltura e l'Analisi dell'Economia Agraria, Unità di Ricerca per il Monitoraggio e la Pianificazione Forestale (CREA-MPF), Piazza Nicolini 6 loc. Villazzano, 38123 Trento, Italy.
authors.forename: Pietro
authors.initials: P
authors.lastname: Fusani
authors.affiliation: Department of Pharmacognosy and Molecular Basis of Phytotherapy, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland.
authors.forename: Iwona
authors.initials: I
authors.lastname: Stanisławska
authors.affiliation: Department of Pharmacognosy and Molecular Basis of Phytotherapy, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland.
authors.forename: Jakub P
authors.initials: JP
authors.lastname: Piwowarski
authors.affiliation: Istituto di Chimica Biomolecolare - Consiglio Nazionale delle Ricerche, Via Campi Flegrei, 34, 80078 Pozzuoli (NA), Italy.
authors.forename: Dominique
authors.initials: D
authors.lastname: Melck
authors.affiliation: Istituto di Chimica Biomolecolare - Consiglio Nazionale delle Ricerche, Via Campi Flegrei, 34, 80078 Pozzuoli (NA), Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Motta
authors.affiliation: Istituto di Chimica Biomolecolare - Consiglio Nazionale delle Ricerche, Via Campi Flegrei, 34, 80078 Pozzuoli (NA), Italy; Pharmazeutisches Institut, Abteilung Pharmazeutische Biologie, Christian-Albrechts-Universität zu Kiel, Gutenbergstraße 76, 24118 Kiel, Germany. Electronic address: czidorn@pharmazie.uni-kiel.de.
authors.forename: Christian
authors.initials: C
authors.lastname: Zidorn
mesh_terms: D045744:Cell Line, Tumor; D049109:Cell Proliferation; D005504:Food Analysis; D006801:Humans; D007558:Italy; D009682:Magnetic Resonance Spectroscopy; D039821:Monoterpenes / Q000032:analysis*; D010936:Plant Extracts / Q000032:analysis / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D011714:Pyrans / Q000032:analysis; D027824:Rosaceae / Q000737:chemistry*; D014675:Vegetables / Q000737:chemistry*
chemical_list: C574448:2-(8'-ethoxy-8'-methylpropylidene)-5-hydroxy-3,6-dihydro-2H-pyran-4-carboxylic acid; D039821:Monoterpenes; D010936:Plant Extracts; D011714:Pyrans
keywords: Aruncus dioicus var. aethusifolius; Aruncus dioicus var. vulgaris; Buck’s beard; Chemosystematics; Monoterpenoids; Plant bioactives; Rosaceae; Vegetables from the wild