title: Effect of Chokeberry Juice on N-Nitrosodiethylamine-Induced Rat Liver Carcinogenesis.
abstract: Because humans commonly consume chokeberry, especially as a nutritional supplement, it must be checked to determine whether its excessive ingestion can cause adverse effects, in particular, in the case of simultaneous exposure to some xenobiotics. From this point of view, we examined the impact of long-term cotreatment of rats with chokeberry juice and hepatic carcinogen N-nitrosodiethylamine (NDEA) on oxidative damages and neoplastic lesions in the liver of rats. Daily exposure to chokeberry juice in a concentration of 10 g/kg feed via diet for 13 wk led to an intensified hepatotoxic effect of NDEA (0.01% in drinking water for 13 wk), as evidenced by changes in histopathological architecture of liver tissue, increased lipid peroxidation, protein carbonyl formation, and DNA degradation. Moreover, we noticed an increase in relative liver weight and a decrease in body weight in this group in comparison to NDEA-alone treated animals. Chokeberry juice applied alone did not cause any adverse effects in rats. On the basis of these findings, it can be concluded that high doses and longterm administration of chokeberry juice may enhance tumor-promoting action of some chemical carcinogens.
authors.affiliation: Department of Toxicology, Poznan University of Medical Sciences, 30 Dojazd Str., 60-631 Poznan, Poland.
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Kujawska
authors.affiliation: Department of Toxicology, Poznan University of Medical Sciences, 30 Dojazd Str., 60-631 Poznan, Poland.
authors.forename: Patrycja
authors.initials: P
authors.lastname: Kant
authors.affiliation: Department of Toxicology, Poznan University of Medical Sciences, 30 Dojazd Str., 60-631 Poznan, Poland.
authors.forename: Irene Hidalgo
authors.initials: IH
authors.lastname: Mayoral
authors.affiliation: Department of Pharmaceutical Biochemistry, Poznan University of Medical Sciences, 4 Swiecicki Str., 60-781, Poznań, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Ignatowicz
authors.affiliation: Department of Clinical Immunology, Poznan University of Medical Sciences, 5d Rokietnicka Str., 60-806 Poznan, Poland.
authors.forename: Jan
authors.initials: J
authors.lastname: Sikora
authors.affiliation: Department of Fruit, Vegetable, and Cereal Technology, Environmental and Life Science University, 37/41 Chelmonski Str., 51-630 Wroclaw, Poland.
authors.forename: Jan
authors.initials: J
authors.lastname: Oszmianski
authors.affiliation: Institute of Plant Origin Food Technology, Poznan University of Life Sciences, 31 Wojska Polskiego Str., 60-642 Poznan, Poland.
authors.forename: Janusz
authors.initials: J
authors.lastname: Czapski
authors.affiliation: Department of Toxicology, Poznan University of Medical Sciences, 30 Dojazd Str., 60-631 Poznan, Poland.
authors.forename: Jadwiga
authors.initials: J
authors.lastname: Jodynis-Liebert
mesh_terms: D000818:Animals; D063646:Carcinogenesis / Q000139:chemically induced / Q000187:drug effects*; D002273:Carcinogens / Q000633:toxicity; D004052:Diethylnitrosamine / Q000633:toxicity*; D000067030:Fruit and Vegetable Juices / Q000032:analysis*; D008099:Liver / Q000187:drug effects; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000628:therapy*; D008297:Male; D046936:Photinia / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
chemical_list: D002273:Carcinogens; D010936:Plant Extracts; D004052:Diethylnitrosamine