title: Hepatitis B virus infection and risk of coronary artery disease: a meta-analysis.
abstract: BACKGROUND
  Hepatitis B virus (HBV)-infected patients might be associated with coronary artery disease (CAD) from process of chronic inflammation. However, available studies yield conflicting results. This meta-analysis was performed to assess risk of CAD in HBV-infected patients.
  
  
  METHODS
  We searched MEDLINE and EMBASE for relevant literatures from database inception to June 2016. Studies comparing the risk of CAD among HBV-infected patients versus subjects without HBV infection using hazard ratio (HR), odd ratios, or relative risk (RR) were included. Random-effect model and generic inverse variance method were used to combine odds ratio (OR) and 95% confidence interval (CI).
  
  
  RESULTS
  A total of five studies, including three cross-sectional studies, one case-control study, and one cohort study, were subjected to analysis. The result demonstrates no significant risk of CAD among chronic HBV-infected patients and subjects without HBV infection (OR, 0.68; 95% CI, 0.40-1.13).
  
  
  CONCLUSIONS
  This meta-analysis did not demonstrate a significantly increased risk of CAD among HBV-infected patients.
authors.affiliation: Department of Internal Medicine, Bassett Medical Center, Cooperstown, NY, USA.
authors.forename: Karn
authors.initials: K
authors.lastname: Wijarnpreecha
authors.affiliation: Department of Internal Medicine, Bassett Medical Center, Cooperstown, NY, USA.
authors.forename: Charat
authors.initials: C
authors.lastname: Thongprayoon
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
authors.forename: Panadeekarn
authors.initials: P
authors.lastname: Panjawatanan
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA; ; Division of Rheumatology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
authors.forename: Patompong
authors.initials: P
authors.lastname: Ungprasert
keywords: Hepatitis B virus (HBV); coronary artery disease (CAD); heart attack; meta-analysis; myocardial infarction