title: Characterizing the reduction of stimulation artifact noise in a tripolar nerve cuff electrode by application of a conductive shield layer.
abstract: Tripolar nerve cuff electrodes have been widely used for measuring peripheral nerve activity. However, despite the high signal-to-noise ratio levels that can be achieved with this recording configuration, the clinical use of cuff electrodes in closed-loop controlled neuroprostheses remains limited. This is largely attributed to artifact noise signals that contaminate the recorded neural activity. In this study, we investigated the use of a conductive shield layer (CSL) as a means of reducing the artifact noise recorded by nerve cuff electrodes. Using both computational simulations and in vivo experiments, we found that the CSL can result in up to an 85% decrease in the recorded artifact signal. Both the electrical conductivity and the surface area of the CSL were identified as important design criteria. Although this study shows that the CSL can significantly reduce artifact noise in tripolar nerve cuff electrodes, long-term implant studies are needed to validate our findings.
authors.affiliation: Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College St, Room 407, M5S 3G9, Toronto, ON, Canada.
authors.forename: Parisa
authors.initials: P
authors.lastname: Sabetian
authors.affiliation: Department of Electrical and Computer Engineering, University of Toronto, 10 King's College Road, Room SFB540, M5S 3G4, Toronto, ON Canada.
authors.forename: Bita
authors.initials: B
authors.lastname: Sadeghlo
authors.affiliation: Department of Electrical and Computer Engineering, University of Toronto, 10 King's College Road, Room SFB540, M5S 3G4, Toronto, ON Canada.
authors.forename: Chengran Harvey
authors.initials: CH
authors.lastname: Zhang
authors.affiliation: Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College St, Room 407, M5S 3G9, Toronto, ON, Canada; Department of Electrical and Computer Engineering, University of Toronto, 10 King's College Road, Room SFB540, M5S 3G4, Toronto, ON Canada. Electronic address: paul.yoo@utoronto.ca.
authors.forename: Paul B
authors.initials: PB
authors.lastname: Yoo
mesh_terms: D000200:Action Potentials; D000818:Animals; D016477:Artifacts; D004553:Electric Conductivity; D004567:Electrodes, Implanted; D005240:Feasibility Studies; D005260:Female; D010525:Peripheral Nerves / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D059629:Signal-To-Noise Ratio
keywords: Action potential; Artifact signal; Finite element model; Neuroprosthesis; Peripheral nerve recording; Single fiber