title: Salmonella-induced inflammasome activation in humans.
abstract: Inflammasomes are macromolecular complexes that assemble upon recognition of pathogen- or danger-associated molecular patterns. Inflammasome assembly is nucleated by the oligomerisation of specific, activated pattern recognition receptors within the cytosol. Inflammasomes function as platforms for the activation of the caspase-1 protease, which in turn triggers the maturation and secretion of the pro-inflammatory cytokines IL-1β and IL-18, and initiates pyroptosis, a highly inflammatory form of lytic cell death. Recently, additional inflammatory caspases (murine caspase-11, and human caspase-4/5) were also reported to be activated upon a pyroptosis-inducing 'non-canonical inflammasome' by direct recognition of lipopolysaccharide (LPS), a pathogen-associated molecular pattern. Here we review and discuss recent advances in our understanding of inflammasome-mediated host defence against Salmonella particularly in human cells, and their implications for cellular survival and cytokine secretion.
authors.affiliation: Institute for Molecular Bioscience, and Centre for Inflammation and Disease Research, The University of Queensland, St. Lucia, 4072, Australia.
authors.forename: Damien
authors.initials: D
authors.lastname: Bierschenk
authors.affiliation: Institute for Molecular Bioscience, and Centre for Inflammation and Disease Research, The University of Queensland, St. Lucia, 4072, Australia.
authors.forename: Dave
authors.initials: D
authors.lastname: Boucher
authors.affiliation: Institute for Molecular Bioscience, and Centre for Inflammation and Disease Research, The University of Queensland, St. Lucia, 4072, Australia. Electronic address: K.Schroder@imb.uq.edu.au.
authors.forename: Kate
authors.initials: K
authors.lastname: Schroder
mesh_terms: D000818:Animals; D020169:Caspases / Q000378:metabolism; D054884:Host-Pathogen Interactions / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D058847:Inflammasomes / Q000276:immunology* / Q000378:metabolism; D020382:Interleukin-18 / Q000378:metabolism; D053583:Interleukin-1beta / Q000378:metabolism; D007413:Intestinal Mucosa / Q000276:immunology / Q000382:microbiology; D008264:Macrophages / Q000276:immunology; D051379:Mice; D000070576:NLR Proteins / Q000378:metabolism; D000069452:Pathogen-Associated Molecular Pattern Molecules / Q000276:immunology; D000069292:Pyroptosis; D012480:Salmonella Infections / Q000276:immunology* / Q000473:pathology; D012486:Salmonella typhimurium / Q000276:immunology* / Q000472:pathogenicity; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000378:metabolism
chemical_list: D058847:Inflammasomes; D020382:Interleukin-18; D053583:Interleukin-1beta; D000070576:NLR Proteins; D000069452:Pathogen-Associated Molecular Pattern Molecules; D051193:Toll-Like Receptors; D020169:Caspases
keywords: Caspase; Inflammasome; NOD-like receptor; Salmonella; Toll-like receptor