title: Autonomic function and control of pancreatic somatostatin.
abstract: In the canine pancreas alpha and beta adrenergic receptors exist on D cells with α stimulation inhibiting and β stimulation increasing somatostatin release. There are no dopaminergic receptors on D cells. Stimulation of muscarinic receptors causes mild inhibition of somatostatin secretion. Autonomic receptors on the D cell may be physiologically stimulated in vivo via local ganglionic and/or central autonomic drivers.
authors.affiliation: Veterans Administration Medical Center and Department of Medicine, University of Louisville School of Medicine, Louisville, Kentucky, USA.|Department of Medicine, Medical College of Virginia, Richmond, Virginia, USA.
authors.forename: E
authors.initials: E
authors.lastname: Samols
authors.affiliation: Veterans Administration Medical Center and Department of Medicine, University of Louisville School of Medicine, Louisville, Kentucky, USA.|Department of Medicine, Medical College of Virginia, Richmond, Virginia, USA.
authors.forename: J I
authors.initials: JI
authors.lastname: Stagner
authors.affiliation: Veterans Administration Medical Center and Department of Medicine, University of Louisville School of Medicine, Louisville, Kentucky, USA.|Department of Medicine, Medical College of Virginia, Richmond, Virginia, USA.
authors.forename: G C
authors.initials: GC
authors.lastname: Weir
keywords: Somatostatin; acetylcholine; adrenergic receptors; autonomic; cholinergic receptors; dopamine; glucagon; insulin; pancreas