title: Modular cementless prosthetic reconstruction after resection of lower extremity malignant tumor.
abstract: BACKGROUND
  The aim of the study is to report the preliminary clinical and functional outcomes of a modular cementless tumor resection prosthesis system (Megasystem-C®, Waldemar Link GmbH&Co. KG, Hamburg, Germany) in patients undergoing limb salvage surgery with wide resection in a lower extremity primary or metastatic malignant bone tumor.
  
  
  METHODS
  Fifty-two consecutive patients (33 male and 19 female; mean age 37.1 years (range, 16 to 79) with primary or metastatic lower extremity malignant bone tumor who underwent wide resection and reconstruction with cementless Megasystem-C®system were included in the study. Patients were analyzed for age at diagnosis, gender, type and localization of the tumor, time of follow-up, patient and prosthesis survival, complications, oncological and functional outcomes.
  
  
  RESULTS
  Mean follow-up time was 43.2 months (range, 8 to 66). Cumulative patient survival rate was 92.3 percent and cumulative prosthetic survival rate was 65.4 percent. 18 complications were recorded and 9 of them required revision (17.3 percent). Mean overall Musculoskeletal Tumor Society score score was 72.7 percent (range, 52 to 86). Subgroup analyzes demonstrated no difference in complication rates, overall patient or prosthetic survivals. Functional scores according to age, diagnosis and location of the reconstruction also were not significantly different.
  
  
  CONCLUSIONS
  The preliminary short-term follow-up results revealed that, the new generation modular cementless endoprosthetic system offers promising clinical and functional outcomes with reasonable complication rates.
  
  
  METHODS
  Level IV, Therapeutic study.
authors.affiliation: Cankaya Hospital Ankara, Turkey. Electronic address: drsenolbekmez@gmail.com.
authors.forename: Senol
authors.initials: S
authors.lastname: Bekmez
authors.affiliation: Hacettepe University, Faculty of Medicine, Ankara, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Ayvaz
authors.affiliation: Hacettepe University, Faculty of Medicine, Ankara, Turkey.
authors.forename: Altug
authors.initials: A
authors.lastname: Yucekul
authors.affiliation: Hacettepe University, Faculty of Medicine, Ankara, Turkey.
authors.forename: Mazhar
authors.initials: M
authors.lastname: Tokgozoglu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000401:mortality* / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D023821:Limb Salvage; D035002:Lower Extremity / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology; D011446:Prospective Studies; D011475:Prosthesis Failure; D019919:Prosthesis Implantation; D011859:Radiography; D012086:Reoperation; D016896:Treatment Outcome; D055815:Young Adult
keywords: Bone tumor; Cementless; Limb salvage; Modular; Tumor prosthesis