title: Somatostatin: One of the Rare Multifunctional Inhibitors of Mammalian Species.
abstract: This review article has for major main objectives to give an overlook of the major physiological effects of somatostatin on different organs. It will cover first the general aspect of the hormone, its cDNA and its protein maturation process, as well as its characterization in various organs. This aspect will be followed by the factors involved in the control of its secretion, its intracellular mode of action, and its general action on physiological processes. Secondly, the review will focus on the pancreas, looking at its in vivo and in vitro actions with special attention on its effects on normal pancreas growth and pancreatic tumors.
authors.affiliation: From the Département de Médecine, Faculté de Médecine, Université de Sherbrooke, Sherbrooke, Québec, Canada.
authors.forename: Jean
authors.initials: J
authors.lastname: Morisset
mesh_terms: D000818:Animals; D006801:Humans; D018358:Neuroendocrine Tumors / Q000188:drug therapy; D015282:Octreotide / Q000378:metabolism / Q000627:therapeutic use; D010179:Pancreas / Q000166:cytology / Q000378:metabolism*; D010190:Pancreatic Neoplasms / Q000188:drug therapy*; D013004:Somatostatin / Q000031:analogs & derivatives / Q000378:metabolism* / Q000627:therapeutic use*
chemical_list: D013004:Somatostatin; D015282:Octreotide