title: Epileptic seizure, as the first symptom of hypoparathyroidism in children, does not require antiepileptic drugs.
abstract: OBJECTIVE
  Patients with hypoparathyroidism exhibit metabolic disorders (hypocalcemia) and brain structural abnormalities (brain calcifications). Currently, studies have determined whether antiepileptic drug (AED) treatment is required for epileptic seizures in children with hypoparathyroidism.
  
  
  METHODS
  This study aims to evaluate the data of two medical centers in Beijing based on the diagnosis of epileptic seizures as the first symptom of hypoparathyroidism in children.
  
  
  RESULTS
  A total of 42 patients were included and assigned into AED and non-AED treatment groups in a 1:2 matched case-control study. Results show that the seizure outcome after 1 year of AED treatment is not significantly different from that of the control. In the subgroup analysis of patients with subcortical calcifications, the seizure outcome is still not significantly different from that of the control.
  
  
  CONCLUSIONS
  Thus, AED treatment cannot improve the seizure outcomes in children with parathyroid disorder, even in such cases as suspected structural seizure caused by subcortical calcifications. Clinicians must take adequate considerations on the use of AEDs in these patients. Epileptic seizures, as the first symptom of hypoparathyroidism in children, do not require epilepsy drugs.
authors.affiliation: Department of Pediatrics, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.
authors.forename: Meng-Jia
authors.initials: MJ
authors.lastname: Liu
authors.affiliation: Department of Neurology, Beijing Children's Hospital, Beijing, 100045, China.
authors.forename: Jiu-Wei
authors.initials: JW
authors.lastname: Li
authors.affiliation: Department of Pediatrics, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.
authors.forename: Xiu-Yu
authors.initials: XY
authors.lastname: Shi
authors.affiliation: Department of Pediatrics, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.
authors.forename: Lin-Yan
authors.initials: LY
authors.lastname: Hu
authors.affiliation: Department of Pediatrics, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China. zouliping21@hotmail.com.|Center of Epilepsy, Beijing Institute for Brain Disorders, Beijing, 100000, China. zouliping21@hotmail.com.
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Zou
mesh_terms: D000293:Adolescent; D000927:Anticonvulsants / Q000627:therapeutic use*; D002118:Calcium / Q000378:metabolism; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography; D004827:Epilepsy / Q000209:etiology*; D005260:Female; D006801:Humans; D007011:Hypoparathyroidism / Q000150:complications*; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012189:Retrospective Studies; D015898:Tomography Scanners, X-Ray Computed
chemical_list: D000927:Anticonvulsants; D002118:Calcium
keywords: Epilepsy; Hypocalcemia; Intracranial calcification; Parathyroid