title: Potential hypoglycaemic activity phenolic glycosides from Moringa oleifera seeds.
abstract: Moringa oleifera seed has remarkable curative effects on reducing blood pressure, blood sugar and enhancing human immunity. In this study, one novel phenolic glycoside (1) together with four known compounds 2-5 were isolated from the macroporous resin adsorption extract of M. oleifera seeds, and the compound 3 was reported for the first time from this plant. The structure of the new crystalline compound was determined on the basis of spectroscopic analyses including mass spectrometry, 1D and 2D NMR experiments. The hypoglycaemic activity of isolated compounds was investigated with HepG2 cell and STZ-induced mice. It was found that compound 1, 4 and 5 could promote the glucose consumption of insulin resistance cells and reduce blood glucose levels of STZ-induced mice. This study concludes that compound 1, 4 and 5 may be developed as new and safe hypoglycaemic drugs.
authors.affiliation: a College of Pharmacy , Nanjing University of Chinese Medicine , Nanjing , P.R. China.
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.affiliation: a College of Pharmacy , Nanjing University of Chinese Medicine , Nanjing , P.R. China.
authors.forename: Huan-Huan
authors.initials: HH
authors.lastname: Zhong
authors.affiliation: a College of Pharmacy , Nanjing University of Chinese Medicine , Nanjing , P.R. China.
authors.forename: Wei-Ke
authors.initials: WK
authors.lastname: Chen
authors.affiliation: a College of Pharmacy , Nanjing University of Chinese Medicine , Nanjing , P.R. China.
authors.forename: Qing-Pu
authors.initials: QP
authors.lastname: Liu
authors.affiliation: a College of Pharmacy , Nanjing University of Chinese Medicine , Nanjing , P.R. China.|b Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization , Jiangsu , P.R. China.
authors.forename: Cun-Yu
authors.initials: CY
authors.lastname: Li
authors.affiliation: a College of Pharmacy , Nanjing University of Chinese Medicine , Nanjing , P.R. China.|b Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization , Jiangsu , P.R. China.
authors.forename: Yun-Feng
authors.initials: YF
authors.lastname: Zheng
authors.affiliation: a College of Pharmacy , Nanjing University of Chinese Medicine , Nanjing , P.R. China.|b Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization , Jiangsu , P.R. China.
authors.forename: Guo-Ping
authors.initials: GP
authors.lastname: Peng
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006027:Glycosides / Q000737:chemistry / Q000494:pharmacology*; D056945:Hep G2 Cells; D006801:Humans; D007004:Hypoglycemic Agents / Q000737:chemistry* / Q000494:pharmacology*; D007333:Insulin Resistance; D009682:Magnetic Resonance Spectroscopy; D008813:Mice, Inbred ICR; D015394:Molecular Structure; D029588:Moringa oleifera / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry; D012639:Seeds / Q000737:chemistry
chemical_list: D001786:Blood Glucose; D006027:Glycosides; D007004:Hypoglycemic Agents; D010636:Phenols; D010936:Plant Extracts
keywords: HepG 2 cell; Moringa oleifera; hypoglycemic activity; phenolic glycoside