title: Pharmacological Blockade of the Chemokine Receptor CCR1 Protects Mice from Systemic Candidiasis of Hematogenous Origin.
abstract: Systemic candidiasis is a leading cause of nosocomial bloodstream infection with a high mortality rate despite treatment. Immune-based strategies are needed to improve outcomes. We previously reported that genetic deficiency in the chemokine receptor CCR1 improves survival and ameliorates tissue damage inCandida-infected mice. Here, we found that treatment of immunocompetentCandida-infected mice with the CCR1-selective antagonist BL5923 improves survival, decreases the kidney fungal burden, and protects from renal tissue injury.
authors.affiliation: Fungal Pathogenesis Unit, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA lionakism@mail.nih.gov dkontoyi@mdanderson.org.
authors.forename: Michail S
authors.initials: MS
authors.lastname: Lionakis
authors.affiliation: Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
authors.forename: Nathaniel D
authors.initials: ND
authors.lastname: Albert
authors.affiliation: Fungal Pathogenesis Unit, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: Muthulekha
authors.initials: M
authors.lastname: Swamydas
authors.affiliation: Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: Chyi-Chia R
authors.initials: CR
authors.lastname: Lee
authors.affiliation: Autoimmunity, Transplantation and Inflammation, Novartis Institutes for Biomedical Research, Basel, Switzerland.
authors.forename: Pius
authors.initials: P
authors.lastname: Loetscher
authors.affiliation: Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA lionakism@mail.nih.gov dkontoyi@mdanderson.org.
authors.forename: Dimitrios P
authors.initials: DP
authors.lastname: Kontoyiannis
mesh_terms: D058186:Acute Kidney Injury / Q000276:immunology / Q000382:microbiology / Q000401:mortality / Q000517:prevention & control*; D000818:Animals; D002176:Candida albicans / Q000187:drug effects* / Q000254:growth & development / Q000472:pathogenicity; D058365:Candidiasis, Invasive / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology / Q000401:mortality; D004334:Drug Administration Schedule; D005260:Female; D015870:Gene Expression; D006470:Hemorrhage / Q000276:immunology / Q000382:microbiology / Q000401:mortality / Q000517:prevention & control*; D054884:Host-Pathogen Interactions; D051379:Mice; D008810:Mice, Inbred C57BL; D010879:Piperazines / Q000494:pharmacology*; D054389:Receptors, CCR1 / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000276:immunology; D016019:Survival Analysis
chemical_list: C515301:Ccr1 protein, mouse; D010879:Piperazines; D054389:Receptors, CCR1
keywords: CCR1; Candida; candidiasis; chemokine receptor