title: Therapeutic effects of intralipid and medialipid emulsionsin a rat model of verapamil toxicity.
abstract: OBJECTIVE
  Lipid emulsions are promising as a potential new therapy for severe verapamil overdose. Our purpose is to draw attention to the choice of solution by investigating the efficacy of intralipid 20% or medialipid 20% in verapamil overdose.
  
  
  METHODS
  Eighteen adult Sprague Dawley rats were randomly divided into three groups: control (saline; Group C), intralipid 20% (Group I), and medialipid 20% (Group M). Rats were anesthetized with ketamine. Blood gas analysis, baseline heart rate (HRb), and mean arterial pressure (MAPb) were evaluated. Verapamil at 2.5 mg kg-1min-1was infused until the HRband MAPbdecreased by 50% and the times to HR0and MAP0were recorded. Treatment solutions of the groups were administered as 12.4 mL kg-1in 5 min.
  
  
  RESULTS
  While HR did not show a difference, MAP showed statistically significant differences among the groups. Intralipid 20% was more efficient than the other two treatments at an early stage; however, as the administration time progressed, medialipid 20% also turned out to be more efficient than the control treatment.
  
  
  CONCLUSIONS
  Our findings indicate that in a toxicity model of rats produced with verapamil, intralipid 20% and medialipid 20% solutions partially eliminate cardiac-depressant effects and increase the survival rate.
authors.affiliation: Department of Anesthesiology and Reanimation, Faculty of Medicine, Gazi University, Ankara, Turkey.
authors.forename: Fatma
authors.initials: F
authors.lastname: Akgün Şahin
authors.affiliation: Department of Anesthesiology and Reanimation, Faculty of Medicine, Gazi University, Ankara, Turkey.
authors.forename: Sıdıka Hülya
authors.initials: SH
authors.lastname: Çelebi
authors.affiliation: Department of Anesthesiology and Reanimation, Faculty of Medicine, Gazi University, Ankara, Turkey.
authors.forename: İrfan
authors.initials: İ
authors.lastname: Güngör
authors.affiliation: Department of Anesthesiology and Reanimation, Faculty of Medicine, Gazi University, Ankara, Turkey.
authors.forename: Demet
authors.initials: D
authors.lastname: Coşkun
authors.affiliation: Laboratory Animal Breeding and Experimental Research Center, Faculty of Medicine, Gazi University, Ankara, Turkey.
authors.forename: Elif
authors.initials: E
authors.lastname: Ergüven Kaya
mesh_terms: D000818:Animals; D001794:Blood Pressure; D051381:Rats; D017207:Rats, Sprague-Dawley; D013024:Soybean Oil / Q000627:therapeutic use*; D014700:Verapamil
chemical_list: D013024:Soybean Oil; D014700:Verapamil
keywords: Verapamil; cardiovascular collapse; intralipid; medialipid; toxicity