title: In vivo super-resolution retinal imaging through virtually structured detection.
abstract: High resolution is important for sensitive detection of subtle distortions of retinal morphology at an early stage of eye diseases. We demonstrate virtually structured detection (VSD) as a feasible method to achieve in vivo super-resolution ophthalmoscopy. A line-scanning strategy was employed to achieve a super-resolution imaging speed up to 127 ?? frames / s with a frame size of 512 × 512 ?? pixels . The proof-of-concept experiment was performed on anesthetized frogs. VSD-based super-resolution images reveal individual photoreceptors and nerve fiber bundles unambiguously. Both image contrast and signal-to-noise ratio are significantly improved due to the VSD implementation.
authors.affiliation: University of Illinois at Chicago, Department of Bioengineering, 851 South Morgen Street, Chicago, Illinois 60607, United States.
authors.forename: Changgeng
authors.initials: C
authors.lastname: Liu
authors.affiliation: University of Illinois at Chicago, Department of Bioengineering, 851 South Morgen Street, Chicago, Illinois 60607, United States.
authors.forename: Yanan
authors.initials: Y
authors.lastname: Zhi
authors.affiliation: University of Illinois at Chicago, Department of Bioengineering, 851 South Morgen Street, Chicago, Illinois 60607, United States.
authors.forename: Benquan
authors.initials: B
authors.lastname: Wang
authors.affiliation: University of Illinois at Chicago, Department of Bioengineering, 851 South Morgen Street, Chicago, Illinois 60607, United States.
authors.forename: Damber
authors.initials: D
authors.lastname: Thapa
authors.affiliation: University of Illinois at Chicago, Department of Bioengineering, 851 South Morgen Street, Chicago, Illinois 60607, United States.
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Chen
authors.affiliation: University of Illinois at Chicago, Department of Bioengineering, 851 South Morgen Street, Chicago, Illinois 60607, United States.
authors.forename: Minhaj
authors.initials: M
authors.lastname: Alam
authors.affiliation: University of Illinois at Chicago, Department of Bioengineering, 851 South Morgen Street, Chicago, Illinois 60607, United States.
authors.forename: Yiming
authors.initials: Y
authors.lastname: Lu
authors.affiliation: University of Illinois at Chicago, Department of Bioengineering, 851 South Morgen Street, Chicago, Illinois 60607, United StatesbUniversity of Illinois at Chicago, Department of Ophthalmology and Visual Sciences, 1905 West Taylor Street, Chicago, Illinois 60612, United States.
authors.forename: Xincheng
authors.initials: X
authors.lastname: Yao
mesh_terms: D000818:Animals; D001001:Anura; D004867:Equipment Design; D006801:Humans; D008853:Microscopy / Q000295:instrumentation / Q000379:methods; D009887:Ophthalmoscopy / Q000379:methods*; D012160:Retina / Q000166:cytology / Q000000981:diagnostic imaging*; D059629:Signal-To-Noise Ratio