title: Efficacy of mitomycin-C and infliximab in reducing adhesionand fibrosis following strabismus surgery.
abstract: OBJECTIVE
  The present study aimed to investigate the efficacy of mitomycin-C (MMC) and infliximab (INF) in reducing adhesion and fibrosis following strabismus surgery.
  
  
  METHODS
  Forty eyes of 20 albino rabbits were separated into MMC and INF groups. Right and left eyes of rabbits were assigned to the drug and control groups, respectively. The superior rectus muscle was disinserted, the drug was administered to the surgical area for 5 min in the drug eyes (MMC 0.2 mg/mL or INF 5 mg/mL), and physiological saline was administered to the control eyes. Surgical areas were rinsed with 10 mL of physiological saline. The disinserted muscle was then sutured to the same area using 6.0 Vicryl. The rabbits were sacrificed after 4 weeks for histopathological examination.
  
  
  RESULTS
  Significant reduction was observed in fibrosis in the INF group as compared to the control group (P = 0.005). Although adhesion formation in the drug eyes reduced in the MMC and INF groups as compared to the control group, the difference was not significant (P = 0.280 and P = 0.579, respectively).
  
  
  CONCLUSIONS
  This study demonstrated the fibrosis-preventing efficacy of IFN; thus, it can be a good option in reducing fibrosis in strabismus surgery.
authors.affiliation: Eye Clinic, Ersin Arslan State Hospital, Gaziantep, Turkey.
authors.forename: Emin Serbülent
authors.initials: ES
authors.lastname: Güçlü
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, Mersin University, Mersin, Turkey.
authors.forename: Ayşe Ayça
authors.initials: AA
authors.lastname: Sarı
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, Mersin University, Mersin, Turkey.
authors.forename: Erdem
authors.initials: E
authors.lastname: Dinç
authors.affiliation: Department of Histology and Embryology, Faculty of Medicine, Mersin University, Mersin, Turkey.
authors.forename: Tuba
authors.initials: T
authors.lastname: Özcan Metin
authors.affiliation: Department of Histology and Embryology, Faculty of Medicine, Mersin University, Mersin, Turkey.
authors.forename: Banu
authors.initials: B
authors.lastname: Çoşkun Yılmaz
authors.affiliation: Department of Biostatistics, Faculty of Medicine, Mersin University, Mersin, Turkey.
authors.forename: Bahar
authors.initials: B
authors.lastname: Taşdelen
mesh_terms: D000818:Animals; D000069285:Infliximab; D016685:Mitomycin; D009801:Oculomotor Muscles; D011183:Postoperative Complications; D011817:Rabbits; D013285:Strabismus / Q000601:surgery*
chemical_list: D016685:Mitomycin; D000069285:Infliximab
keywords: Strabismus surgery; adhesion; fibrosis; infliximab; mitomycin-C