title: Brief Review and a Clinical Case of Hemolytic Uremic Syndrome Associated with Interferon β Treatment.
abstract: The hemolytic uremic syndrome (HUS) is one of the thrombotic microangiopathies and it consists of the triad of nonimmune microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury. The atypical form of HUS (aHUS) is related to causative mutations in complement genes. Some conditions act as a trigger for aHUS in individuals that have a genetic background predisposing to complement activation. Interferon β is a recombinant-protein therapy approved to treat multiple sclerosis (MS), and can be a causative agent in the occurrence of HUS through anti-angiogenic activity. In this paper, we briefly review aHUS clinical and genetic characteristics. Furthermore, we present a case of a 48-year-old woman, diagnosed with MS and treated with INFβ-1b from 2008. In December 2015, she presented with asthenia and loss of muscular strength in the legs and she quickly developed aHUS. Our case suggests that INFβ is a possible triggering factor for HUS.
authors.affiliation: Department of Nephrology, Dialysis and Transplant, San Bortolo Hospital, Vicenza, Italy.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Milan Manani
authors.forename: Grazia Maria
authors.initials: GM
authors.lastname: Virzì
authors.forename: Fiorella
authors.initials: F
authors.lastname: Gastaldon
authors.forename: Marta
authors.initials: M
authors.lastname: Proglio
authors.forename: Alessandra
authors.initials: A
authors.lastname: Brocca
authors.forename: Claudio
authors.initials: C
authors.lastname: Ronco
mesh_terms: D001247:Asthenia; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000139:chemically induced* / Q000209:etiology; D006801:Humans; D007155:Immunologic Factors; D016899:Interferon-beta / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications* / Q000188:drug therapy; D053580:Muscle Strength
chemical_list: D007155:Immunologic Factors; D016899:Interferon-beta