title: Noninvasive amide proton transfer magnetic resonance imaging in evaluating the grading and cellularity of gliomas.
abstract: Using noninvasive magnetic resonance imaging techniques to accurately evaluate the grading and cellularity of gliomas is beneficial for improving the patient outcomes. Amide proton transfer imaging is a noninvasive molecular magnetic resonance imaging technique based on chemical exchange saturation transfer mechanism that detects endogenous mobile proteins and peptides in biological tissues. Between August 2012 and November 2015, a total number of 44 patients with pathologically proven gliomas were included in this study. We compared the capability of amide proton transfer magnetic resonance imaging with that of noninvasive diffusion-weighted imaging and noninvasive 3-dimensional pseudo-continuous arterial spin imaging in evaluating the grading and cellularity of gliomas. Our results reveal that amide proton transfer magnetic resonance imaging is a superior imaging technique to diffusion-weighted imaging and 3-dimensional pseudo-continuous arterial spin imaging in the grading of gliomas. In addition, our results showed that the Ki-67 index correlated better with the amide proton transfer-weighted signal intensity than with the apparent diffusion coefficient value or the cerebral blood flow value in the gliomas. Amide proton transfer magnetic resonance imaging is a promising method for predicting the grading and cellularity of gliomas.
authors.affiliation: Department of Radiology, Zhengzhou University People's Hospital & Henan Provincial People's Hospital, Zhengzhou, Henan, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Bai
authors.affiliation: Cooperative Innovation Center of Internet Healthcare & School of Software and Applied Technology, Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Yusong
authors.initials: Y
authors.lastname: Lin
authors.affiliation: Department of Radiology, Ren Ji Hospital of Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Pathology, Zhengzhou University People's Hospital & Henan Provincial People's Hospital, Zhengzhou, Henan, China.
authors.forename: Lingfei
authors.initials: L
authors.lastname: Kong
authors.affiliation: Department of Pathology, Zhengzhou University People's Hospital & Henan Provincial People's Hospital, Zhengzhou, Henan, China.
authors.forename: Lifu
authors.initials: L
authors.lastname: Wang
authors.affiliation: MR Collaborations NE Asia, Siemens Healthcare China, Beijing, China.
authors.forename: Panli
authors.initials: P
authors.lastname: Zuo
authors.affiliation: MR Collaborations NE Asia, Siemens Healthcare China, Shanghai, China.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Vallines
authors.affiliation: Imaging & Therapy Systems Division, Siemens Healthcare Australia, Brisbane, Australia.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Schmitt
authors.affiliation: Institute of Automation, Chinese Academy of Sciences, Beijing, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Tian
authors.affiliation: Department of Radiology, Johns Hopkins University, Baltimore, MD, USA.
authors.forename: Xiaolei
authors.initials: X
authors.lastname: Song
authors.affiliation: Department of Radiology, Johns Hopkins University, Baltimore, MD, USA.
authors.forename: Jinyuan
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Department of Radiology, Zhengzhou University People's Hospital & Henan Provincial People's Hospital, Zhengzhou, Henan, China.
authors.forename: Meiyun
authors.initials: M
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D005260:Female; D005910:Glioma / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D019394:Ki-67 Antigen / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading
chemical_list: D019394:Ki-67 Antigen
keywords: Ki-67; amide proton transfer; glioma; grading; magnetic resonance imaging