title: pH-Modulating Poly(ethylene glycol)/Alginate Hydrogel Dressings for the Treatment of Chronic Wounds.
abstract: The development of chronic wounds has been frequently associated with alkaline pH values. The application of pH-modulating wound dressings can, therefore, be a promising treatment option to promote normal wound healing. This study reports on the development and characterization of acidic hydrogel dressings based on interpenetrating poly(ethylene glycol) diacrylate/acrylic acid/alginate networks. The incorporation of ionizable carboxylic acid groups results in high liquid uptake up to 500%. The combination of two separate polymer networks significantly improves the tensile and compressive stability. In a 2D cell migration assay, the application of hydrogels (0% to 1.5% acrylic acid) results in complete "wound" closure; hydrogels with 0.25% acrylic acid significantly increase the cell migration velocity to 19.8 ± 1.9 µm h-1. The most promising formulation (hydrogels with 0.25% acrylic acid) is tested on 3D human skin constructs, increasing keratinocyte ingrowth into the wound by 164%.
authors.affiliation: Department of Pharmaceutical Technology, University of Regensburg, Universitätsstr. 31, 93053, Regensburg, Germany.
authors.forename: Julia
authors.initials: J
authors.lastname: Koehler
authors.affiliation: Institute of Pharmacy, Pharmacology and Toxicology, Freie Universität Berlin, Königin-Luise-Str. 2+4, 14195, Berlin, Germany.
authors.forename: Leonie
authors.initials: L
authors.lastname: Wallmeyer
authors.affiliation: Institute of Pharmacy, Pharmacology and Toxicology, Freie Universität Berlin, Königin-Luise-Str. 2+4, 14195, Berlin, Germany.
authors.forename: Sarah
authors.initials: S
authors.lastname: Hedtrich
authors.affiliation: Department of Pharmaceutical Technology, University of Regensburg, Universitätsstr. 31, 93053, Regensburg, Germany.
authors.forename: Achim M
authors.initials: AM
authors.lastname: Goepferich
authors.affiliation: Department of Pharmaceutical Technology, University of Regensburg, Universitätsstr. 31, 93053, Regensburg, Germany.
authors.forename: Ferdinand P
authors.initials: FP
authors.lastname: Brandl
mesh_terms: D000464:Alginates / Q000737:chemistry*; D001458:Bandages; D002478:Cells, Cultured; D002908:Chronic Disease; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D006801:Humans; D020100:Hydrogels / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D011092:Polyethylene Glycols / Q000737:chemistry*; D014945:Wound Healing; D014947:Wounds and Injuries / Q000628:therapy*
chemical_list: D000464:Alginates; D006603:Hexuronic Acids; D020100:Hydrogels; D011092:Polyethylene Glycols; D020723:Glucuronic Acid
keywords: chronic wound; hydrogels; interpenetrating networks (IPN); reconstructed human skin; wound dressing