title: Antibiofilm Activity of Plant Polyphenols.
abstract: In the history of human medicine, antibiotics represent epochal examples of medical progress. However, with an approaching antibiotic crisis due to the emergence and extensive spread of antimicrobial resistance among bacterial agents, as well as to increasing number of patients with chronic and recalcitrant bacterial biofilm-associated infections, the naturally occurring molecules may become new sources of antibacterial and antibiofilm drugs for clinical usage. Polyphenols represent a class of plant natural products which are important in plant defense against microbial pathogens. The main focus of the review is on the antibiofilm activities of phenolic compounds against bacteria which play an essential role in medical device biofilm-associated infections. The other, not negligible part of the review is devoted to polyphenols' activity against bacterial agents that cause dental caries and periodontal disease.
authors.affiliation: Institute of Microbiology of the Medical Faculty and the University Hospital in Bratislava, Comenius University in Bratislava, 811 08 Bratislava, Slovakia. livia.slobodnikova@fmed.uniba.sk.
authors.forename: Lívia
authors.initials: L
authors.lastname: Slobodníková
authors.affiliation: Department of Pharmacognosy and Botany, Faculty of Pharmacy, Comenius University in Bratislava, 832 32 Bratislava, Slovakia. fialova@fpharm.uniba.sk.
authors.forename: Silvia
authors.initials: S
authors.lastname: Fialová
authors.affiliation: Department of Pharmacognosy and Botany, Faculty of Pharmacy, Comenius University in Bratislava, 832 32 Bratislava, Slovakia. rendekova18@uniba.sk.
authors.forename: Katarína
authors.initials: K
authors.lastname: Rendeková
authors.affiliation: Department of Stomatology and Maxillofacial Surgery of the Medical Faculty and the University Hospital in Bratislava, Comenius University in Bratislava, 812 50 Bratislava, Slovakia. mudr.jan.kovac@gmail.com.
authors.forename: Ján
authors.initials: J
authors.lastname: Kováč
authors.affiliation: Department of Pharmacognosy and Botany, Faculty of Pharmacy, Comenius University in Bratislava, 832 32 Bratislava, Slovakia. mucaji@fpharm.uniba.sk.
authors.forename: Pavel
authors.initials: P
authors.lastname: Mučaji
mesh_terms: D018441:Biofilms / Q000187:drug effects*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000382:microbiology; D010510:Periodontal Diseases / Q000188:drug therapy / Q000382:microbiology; D010944:Plants / Q000737:chemistry*; D059808:Polyphenols / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D059808:Polyphenols
keywords: antibacterial activity; bacterial biofilm; dental caries; medical device-associated infection; periodontal disease; plant polyphenols