title: Crystal structure of a 2:1 co-crystal of meloxicam with acetyl-endi-carb-oxy-lic acid.
abstract: The pharmaceutical 2:1 co-crystal of meloxicam [MXM; systematic name: 4-hy-droxy-2-methyl-N-(5-methyl-thia-zol-2-yl)-2H-1,2-benzo-thia-zine-3-carboxamide 1,1-dioxide] with acetyl-enedi-carb-oxy-lic acid (ACA; systematic name: but-2-ynedioic acid), crystallizes with one MXM mol-ecule and half an ACA mol-ecule in the asymmetric unit, C14H13N3O4S2·0.5C4H2O4. The mid-point of the triple bond of ACA is located on an inversion centre. In the crystal, the two stereoisomers of MXM with respect to the N atom of the sulfonamide group are related by the inversion centre. The carbonyl and hy-droxy groups belonging to the MXM mol-ecule are involved in an intra-molecular O-H⋯O hydrogen bond. The structure-forming motif includes two MXM mol-ecules linkedviaan ACA conformer through N-H⋯O and O-H⋯N hydrogen bonds, similar to MXM co-crystals with other di-carb-oxy-lic acids.
authors.affiliation: Novosibirsk State University, Pirogova str. 2, Novosibirsk, 630090, Russian Federation.
authors.forename: Christian
authors.initials: C
authors.lastname: Tantardini
authors.affiliation: Novosibirsk State University, Pirogova str. 2, Novosibirsk, 630090, Russian Federation; Institute of Solid State Chemistry and Mechanochemistry SB RAS, Kutateladze str. 18, Novosibirsk, 630128, Russian Federation.
authors.forename: Sergey G
authors.initials: SG
authors.lastname: Arkhipov
authors.affiliation: Novosibirsk State University, Pirogova str. 2, Novosibirsk, 630090, Russian Federation; Institute of Solid State Chemistry and Mechanochemistry SB RAS, Kutateladze str. 18, Novosibirsk, 630128, Russian Federation.
authors.forename: Ksenya A
authors.initials: KA
authors.lastname: Cherkashina
authors.affiliation: Novosibirsk State University, Pirogova str. 2, Novosibirsk, 630090, Russian Federation; N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Lavrentiev str. 9, Novosibirsk, 630090, Russian Federation.
authors.forename: Alexander S
authors.initials: AS
authors.lastname: Kil'met'ev
authors.affiliation: Institute of Solid State Chemistry and Mechanochemistry SB RAS, Kutateladze str. 18, Novosibirsk, 630128, Russian Federation.
authors.forename: Elena V
authors.initials: EV
authors.lastname: Boldyreva
keywords: acetyl­enedi­carb­oxy­lic acid; co-crystal; crystal structure; di­carb­oxy­lic acid; drugs; hydrogen bonds; meloxicam; oxicam