title: Comparing the symptom experience of cancer patients and non-cancer patients.
abstract: Symptom burden is an established concept in oncology encompassing the presence and severity of symptoms experienced by cancer patients. Few studies have examined differences in symptom burden between cancer patients and non-cancer patients. This study seeks to examine the differences in symptom burden between cancer patients (CP) and non-cancer patients (NCP) in order to better understand symptom burden in both populations.
  
  
  
  Two groups of patients completed the Memorial Symptom Assessment Scale: 301 patients from a general medical clinic and 558 cancer patients from a cancer tumor registry. Participants provided demographic information-age, race/ethnicity, and sex and completed the Memorial Symptom Assessment Scale. Medical comorbidity was also measured.
  
  
  
  Most symptoms were more common in CP, except for pain, which was more prevalent in the NCP (45% of CP vs. 54% of NCP, p < .05). There was no difference in prevalence for the following symptoms: dry mouth, mouth sores, feeling nervous, worry, cough, and dizziness. The CP had greater mean MSAS Total scores (0.53 vs. 0.43, p < .01), number of symptoms (9.11 vs. 6.13, p < .01), and psychological subscale scores (0.77 vs. 0.64, p < .05). There was no difference by group in the physical nor the GDI subscale scores.
  
  
  
  The results of this study support the perception that cancer patients have greater symptom burden. There were some unexpected results, particularly in terms of pain, which was more common in NCP and other symptoms that were experienced equally in both patient populations.
authors.affiliation: Siteman Cancer, Barnes-Jewish Hospital, Washington University School of Medicine, 4921 Parkview Place, MS: 90-35-703, St. Louis, MO, 63110, USA. teresa.deshields@bjc.org.
authors.forename: Teresa L
authors.initials: TL
authors.lastname: Deshields
authors.affiliation: Siteman Cancer, Barnes-Jewish Hospital, Washington University School of Medicine, 4921 Parkview Place, MS: 90-35-703, St. Louis, MO, 63110, USA.
authors.forename: Valentina
authors.initials: V
authors.lastname: Penalba
authors.affiliation: Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, Saint Louis, MO, USA.
authors.forename: Jingxa
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
authors.forename: James
authors.initials: J
authors.lastname: Avery
mesh_terms: D001007:Anxiety / Q000209:etiology; D016022:Case-Control Studies; D015897:Comorbidity; D017281:Cost of Illness; D003371:Cough / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000503:physiopathology* / Q000523:psychology; D010146:Pain / Q000209:etiology; D015995:Prevalence; D011788:Quality of Life; D012720:Severity of Illness Index
keywords: Cancer; Memorial symptom assessment scale; Non-cancer patients; Pain; Symptom prevalence