title: Secondary Metabolites and Biological Activities ofTalaromyces sp.LGT-2,an Endophytic Fungus fromTripterygium Wilfordii.
abstract: In the present study, eleven compounds (1-11) including nine alkaloids (1-9), one triterpenoid saponin (10) and one formamide (11) were isolated fromTalaromyces sp.LGT-2, an endophytic fungus fromTripterygium wilfordi. Their structures were determined based on NMR and ESI-MS spectral data, as well as comparing previous literature data. This is the first report of the isolation of alkaloids (1-9) fromTalaromycesgenus. In the next step, all compounds were screened for their anti-monoamine oxidase, anti-acetylcholinesterase, antibacterial and antitumor activities. Compound 11 showed moderate anti-monoamine oxidase activity with IC50value of 61 μM; compounds 3, 4, 8 showed weaker anti-acetylcholinesterase activity; compounds 1, 3, 4, 7, 8, 9 showed moderate antibacterial activities; compounds 7, 8, 9 showed cytotoxicity against B16 cancer cell line with inhibitory rate of 86%, 82%, 78%, respectively, at the concentration of 500 μg/mL.
authors.affiliation: School of Life Science a Engineering, Lanzhou University of Technology, Lanzhou.
authors.forename: Qiu-Hong
authors.initials: QH
authors.lastname: Zhao
authors.affiliation: School of Life Science a Engineering, Lanzhou University of Technology, Lanzhou.
authors.forename: Zhong-Duo
authors.initials: ZD
authors.lastname: Yang
authors.affiliation: School of Life Science a Engineering, Lanzhou University of Technology, Lanzhou.
authors.forename: Zong-Mei
authors.initials: ZM
authors.lastname: Shu
authors.affiliation: School of Life Science a Engineering, Lanzhou University of Technology, Lanzhou.
authors.forename: Yong-Gang
authors.initials: YG
authors.lastname: Wang
authors.affiliation: School of Life Science a Engineering, Lanzhou University of Technology, Lanzhou.
authors.forename: Ming-Gang
authors.initials: MG
authors.lastname: Wang
keywords: Talaromyces; Tripterygium wilfordi; endophytic fungus; monoamine oxidase inhibition; secondary metabolites