title: Bursting deep dorsal horn neurons: the pharmacological target for the antispastic effects of zolmitriptan?
abstract: In a recent publication, Thaweerattanasinp et al. (J Neurophysiol116: 1644-1653, 2016) investigated spinal cord injury and firing properties of deep dorsal horn neurons during NMDA or zolmitriptan application by employing electrophysiology in an in vitro spinal cord preparation. Deep dorsal horn neurons were classified into bursting, simple, or tonic firing groups,with bursting neurons showing NMDA and zolmitriptan sensitivity. We discuss the findings in a methodological framework and propose future experiments of importance for translating the results into physiological settings.
authors.affiliation: Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; and ecarlsen@sund.ku.dk.
authors.forename: Eva Meier
authors.initials: EM
authors.lastname: Carlsen
authors.affiliation: The Danish Research Institute of Translational Neuroscience (DANDRITE), Nordic EMBL Partnership for Molecular Medicine, Department of Biomedicine, Aarhus University, Aarhus, Denmark.
authors.forename: Rune
authors.initials: R
authors.lastname: Rasmussen
mesh_terms: D023303:Oxazolidinones; D020671:Posterior Horn Cells; D016194:Receptors, N-Methyl-D-Aspartate; D013116:Spinal Cord; D014363:Tryptamines
chemical_list: D023303:Oxazolidinones; D016194:Receptors, N-Methyl-D-Aspartate; D014363:Tryptamines; C089750:zolmitriptan
keywords: 5-HT; NMDA; deep dorsal horn neurons; spinal cord injury; zolmitriptan