title: Neuroinflammation at the interface of depression and cardiovascular disease: Evidence from rodent models of social stress.
abstract: A large body of evidence has emerged linking stressful experiences, particularly from one's social environment, with psychiatric disorders. However, vast individual differences emerge in susceptibility to developing stress-related pathology which may be due to distinct differences in the inflammatory response to social stress. Furthermore, depression is an independent risk factor for cardiovascular disease, another inflammatory-related disease, and results in increased mortality in depressed patients. This review is focused on discussing evidence for stress exposure resulting in persistent or sensitized inflammation in one individual while this response is lacking in others. Particular focus will be directed towards reviewing the literature underlying the impact that neuroinflammation has on neurotransmitters and neuropeptides that could be involved in the pathogenesis of comorbid depression and cardiovascular disease. Finally, the theme throughout the review will be to explore the notion that stress-induced inflammation is a key player in the high rate of comorbidity between psychosocial disorders and cardiovascular disease.
authors.affiliation: Department of Pharmacology Physiology and Neuroscience, University of South Carolina School of Medicine, Columbia, SC 29209, USA.
authors.forename: Julie E
authors.initials: JE
authors.lastname: Finnell
authors.affiliation: Department of Pharmacology Physiology and Neuroscience, University of South Carolina School of Medicine, Columbia, SC 29209, USA.
authors.forename: Susan K
authors.initials: SK
authors.lastname: Wood
keywords: 5-HT, Serotonin; BDNF, Brain-derived neurotrophic factor; CRF, Corticotrophin-releasing factor; CRP, C reactive protein; CVD, Cardiovascular disease; DA, Dopamine; DR, Dorsal raphe; IL, Interleukin; IL-1Ra, Interleukin 1 receptor antagonist; IL-1r2, Interleukin 1 receptor type 2; INF, Interferon; KYN, Kynurenine; LC, Locus coeruleus; LPS, Lipopolysaccharide; MCP, Monocyte chemoattractant protein; NE, Norepinephrine; NPY, Neuropeptide Y; PTSD, Post traumatic stress disorder; SSRI, Selective serotonin re-uptake inhibitor; TNF, Tumor necrosis factor; Trk, Tyrosine receptor kinase