title: CT myocardial perfusion: state of the science.
abstract: Non-invasive cardiac imaging has rapidly evolved during the last decade due to advancements in CT technologies. Coronary CT angiography (CCTA) has been shown to reliably assess the coronary anatomy and has established itself as the non-invasive imaging technique with the highest sensitivity and specificity in the evaluation of patients with suspected coronary artery disease (CAD). However, this technique has previously been limited to a pure anatomical assessment. CT myocardial perfusion imaging (CT-MPI) is an increasingly rediscovered CT technique able to provide functional assessment of the myocardium and, when combined with CTA, allows for a comprehensive assessment of the coronary arteries, all done within a single modality. This review will describe the current knowledge in CT-MPI, including the varying techniques as well as a summary of the current literature.
authors.affiliation: Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, USA.|Department of Radiological Sciences, Oncological and Pathological Sciences University of Rome &quot;Sapienza&quot;, Latina, Italy.
authors.forename: Damiano
authors.initials: D
authors.lastname: Caruso
authors.affiliation: Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, USA.|Department of Radiological Sciences, Oncological and Pathological Sciences University of Rome &quot;Sapienza&quot;, Latina, Italy.
authors.forename: Domenico
authors.initials: D
authors.lastname: DE Santis
authors.affiliation: Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, USA - schoepf@musc.edu.|Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, SC, USA.
authors.forename: U Joseph
authors.initials: UJ
authors.lastname: Schoepf
authors.affiliation: Department of Radiological Sciences, Oncological and Pathological Sciences University of Rome &quot;Sapienza&quot;, Latina, Italy.
authors.forename: Marta
authors.initials: M
authors.lastname: Zerunian
authors.affiliation: Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, USA.
authors.forename: Marwen
authors.initials: M
authors.lastname: Eid
authors.affiliation: Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, USA.
authors.forename: Akos
authors.initials: A
authors.lastname: Varga-Szemes
authors.affiliation: Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, USA.|Department of Cardiology and Intensive Care Medicine, Heart Center Munich-Bogenhausen, Munich, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Tesche
authors.affiliation: Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, USA.
authors.forename: Taylor M
authors.initials: TM
authors.lastname: Duguay
authors.affiliation: Department of Radiological Sciences, Oncological and Pathological Sciences University of Rome &quot;Sapienza&quot;, Latina, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Laghi
authors.affiliation: Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, USA.
authors.forename: Carlo N
authors.initials: CN
authors.lastname: DE Cecco
mesh_terms: D000072226:Computed Tomography Angiography / Q000379:methods; D017023:Coronary Angiography / Q000379:methods; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging*; D006801:Humans; D055414:Myocardial Perfusion Imaging / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*