title: Synthesis, Acaricidal Activity, and Structure-Activity Relationships of Pyrazolyl Acrylonitrile Derivatives.
abstract: A series of novel pyrazolyl acrylonitrile derivatives was designed, targeting Tetranychus cinnabarinus, and synthesized. Their structures were identified by combination of1H NMR,13C NMR, and MS spectra. The structures of compounds 18 and 19 were further confirmed by X-ray diffraction. Extensive greenhouse bioassays indicated that compound 19 exhibits excellent acaricidal activity against all developmental stages of T. cinnabarinus, which is better than the commercialized compounds cyenopyrafen and spirodiclofen. It was shown that the acute toxicity of compounds 19 to mammals is quite low. The structure-activity relationships are also discussed.
authors.affiliation: State Key Laboratory of the Discovery and Development of Novel Pesticide, Shenyang Sinochem Agrochemicals R&D Company Ltd. , Shenyang 110021, People's Republic of China.
authors.forename: Haibo
authors.initials: H
authors.lastname: Yu
authors.affiliation: State Key Laboratory of the Discovery and Development of Novel Pesticide, Shenyang Sinochem Agrochemicals R&D Company Ltd. , Shenyang 110021, People's Republic of China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Cheng
authors.affiliation: State Key Laboratory of the Discovery and Development of Novel Pesticide, Shenyang Sinochem Agrochemicals R&D Company Ltd. , Shenyang 110021, People's Republic of China.
authors.forename: Man
authors.initials: M
authors.lastname: Xu
authors.affiliation: State Key Laboratory of the Discovery and Development of Novel Pesticide, Shenyang Sinochem Agrochemicals R&D Company Ltd. , Shenyang 110021, People's Republic of China.
authors.forename: Yuquan
authors.initials: Y
authors.lastname: Song
authors.affiliation: State Key Laboratory of the Discovery and Development of Novel Pesticide, Shenyang Sinochem Agrochemicals R&D Company Ltd. , Shenyang 110021, People's Republic of China.
authors.forename: Yanmei
authors.initials: Y
authors.lastname: Luo
authors.affiliation: State Key Laboratory of the Discovery and Development of Novel Pesticide, Shenyang Sinochem Agrochemicals R&D Company Ltd. , Shenyang 110021, People's Republic of China.
authors.forename: Bin
authors.identifier: http://orcid.org/0000-0003-4862-7921
authors.initials: B
authors.lastname: Li
mesh_terms: D056810:Acaricides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000181:Acrylonitrile / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D001042:Aphids / Q000187:drug effects; D015195:Drug Design; D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014961:X-Ray Diffraction
chemical_list: D056810:Acaricides; D011720:Pyrazoles; D000181:Acrylonitrile
keywords: acaricidal activity; acrylonitrile; pyrazolyl; spider mite; structure−activity relationship; synthesis