title: Prognostic Significance of Dementia in Older Adults with Solid Tumors.
abstract: The public health burden of cancer and dementia in the geriatric population is well documented. There is limited data on how dementia predicts mortality among geriatric patients with solid tumors. The objective of this study is to determine the prognostic significance of dementia on survival in patients with solid tumors.
  
  
  
  We performed a 5-year retrospective study on elderly subjects aged ≥60 years with and without dementia that were diagnosed with solid tumors.
  
  
  
  Among 3,460 patients with solid tumors, 132 (3.8%) patients were found to have dementia. The median age at diagnosis was 71 years. Kaplan-Meier curves demonstrated that patients with dementia had an inferior median survival compared to the nondemented group (30 vs. 56 months; log-rank p < 0.001). Cox proportional hazard regression modeling identified age >80 years, female gender, diabetes mellitus, congestive heart failure, atrial fibrillation, chronic obstructive pulmonary disease, chronic kidney disease, dementia, and radiation therapy as risk factors for decreased overall survival.
  
  
  
  We demonstrated that dementia is associated with shorter overall survival in elderly patients with solid tumors.
authors.affiliation: Department of Medicine, Einstein Medical Center, Philadelphia, PA, USA.
authors.forename: Supakanya
authors.initials: S
authors.lastname: Wongrakpanich
authors.forename: Amy
authors.initials: A
authors.lastname: Hurst
authors.forename: Jean
authors.initials: J
authors.lastname: Bustamante
authors.forename: Nellowe
authors.initials: N
authors.lastname: Candelario
authors.forename: Sylvia
authors.initials: S
authors.lastname: Biso
authors.forename: Wikrom
authors.initials: W
authors.lastname: Chaiwatcharayut
authors.forename: Claudia
authors.initials: C
authors.lastname: Dourado
authors.forename: Andrew
authors.initials: A
authors.lastname: Rosenzweig
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015897:Comorbidity; D003704:Dementia / Q000150:complications / Q000401:mortality*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D018450:Disease Progression; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications / Q000401:mortality*; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D016019:Survival Analysis