title: Sustained maternal hyperoxygenation improves aortic arch dimensions in fetuses with coarctation.
abstract: The aim was to investigate the impact of maternal hyperoxygenation (HO) on cardiac dimensions in fetuses with isolated Coarctation (CoA). Fetal echocardiography was performed serially in 48 fetuses with CoA and gestation age matched normal fetues. The Z-scores for the mitral valve (MV), tricuspid valve (TV), aortic valve (AV), ascending aorta (AAo), isthmus, pulmonary valve (PV), main pulmonary artery (MPA), and descending aorta (DAo) were measured and compared among normal fetuses, CoA fetuses with oxygen and CoA fetuses with air. In the group with oxygen, 6 L/min oxygen was administered to the mother using a face mask. Regression analyses were performed to identify potential factors for HO outcome. The left heart dimension Z-scores increased gradually during HO therapy periods, especially at 4 weeks after oxygen therapy (P < 0.05). As for the case group with air, the left heart dimension remained unchanged. The duration of HO was associated with aortic arch Z-scores (adjusted R2= 0.199, 0.60 for AAO and isthmus, respectively). Sustained maternal middle-flow oxygenation can be safely used to improve left heart dimensions in fetuses with isolated CoA. The duration of HO were associated with treatment outcome. These findings may provide useful information for developing novel treatment strategies.
authors.affiliation: Department of Ultrasonography, The Second Xiangya Hospital, Central South University, Changsha, P.R. China.
authors.forename: Shi
authors.initials: S
authors.lastname: Zeng
authors.affiliation: Department of Ultrasonography, The Second Xiangya Hospital, Central South University, Changsha, P.R. China.
authors.forename: Jiawei
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Department of Ultrasonography, The Second Xiangya Hospital, Central South University, Changsha, P.R. China.
authors.forename: Qinghai
authors.initials: Q
authors.lastname: Peng
authors.affiliation: Department of Gynecology &Obstetrics, The Second Xiangya Hospital, Central South University, Changsha, P.R. China.
authors.forename: Wen
authors.initials: W
authors.lastname: Deng
authors.affiliation: Department of Ultrasonography, The Second Xiangya Hospital, Central South University, Changsha, P.R. China.
authors.forename: Ming
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Ultrasonography, The Second Xiangya Hospital, Central South University, Changsha, P.R. China.
authors.forename: Yili
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Pediatric, The Second Xiangya Hospital, Central South University, Changsha, P.R. China.
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.affiliation: Department of Ultrasonography, The Second Xiangya Hospital, Central South University, Changsha, P.R. China.
authors.forename: Qichang
authors.initials: Q
authors.lastname: Zhou
mesh_terms: D000328:Adult; D001013:Aorta, Thoracic / Q000033:anatomy & histology*; D001017:Aortic Coarctation / Q000473:pathology* / Q000628:therapy*; D004452:Echocardiography; D005260:Female; D005333:Fetus / Q000033:anatomy & histology*; D006321:Heart / Q000033:anatomy & histology*; D006801:Humans; D006931:Hyperbaric Oxygenation; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D016896:Treatment Outcome