title: Decreased Expression of Selenoproteins as a Poor Prognosticator of Gastric Cancer in Humans.
abstract: The aim of the present study was to analyze the selenoprotein expression levels in gastric cancer patients. We enrolled 40 patients (29 males, 11 females) who were recently diagnosed with gastric cancer and 50 healthy people (30 males, 20 females) as controls. The expression of 25 selenoprotein genes (Dio1, Dio2, Dio3, Gpx1, Gpx2, Gpx3, Gpx4, Gpx6, SelH, SelI, SelK, SelM, SelN, SelO, SelP, SelS, SelT, SelV, SelW, SelX, Sel15, Sps2, TR1, TR2, and TR3) in human gastric cancer tissues, para-carcinoma tissues, adjacent normal gastric tissues, erythrocytes, and lymphocytes in the gastric cancer group and healthy control group was analyzed by qRT-PCR. Here, we showed that among the 25 selenoproteins, 13 selenoproteins in erythrocytes (Gpx1, Gpx4, Sel15, TR1, TR2, SelH, SelK, SelM, SelO, SelS, SelV, SelW, and Sps2), 15 selenoproteins in lymphocytes (Gpx1, Gpx4, Sel15, TR1, TR2, SelH, SelK, SelN, SelO, SelS, SelT, SelV, SelX, SelW, and Sps2) and 13 selenoproteins in gastric cancer and para-carcinoma tissues (Dio1, Dio2, Dio3, Gpx1, Gpx4, Sel15, SelH, SelK, SelM, SelS, SelT, SelW, and Sps2) were significantly decreased (P < 0.05) in the gastric cancer group compared to the control group. In summary, the decreasing expression of selenoprotein genes in gastric cancer patients play an important role in the gastric cancer, although further studies are needed to better understand our findings.
authors.affiliation: Department of Gastroenterological Surgery, The Affiliated Tumor Hospital of Harbin Medical University, 150 Haping Road, Nangang District, Harbin, 150081, China.
authors.forename: Xiuwen
authors.initials: X
authors.lastname: Lan
authors.affiliation: Department of Gastroenterological Surgery, The Affiliated Tumor Hospital of Harbin Medical University, 150 Haping Road, Nangang District, Harbin, 150081, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Xing
authors.affiliation: Department of Gastroenterological Surgery, The Affiliated Tumor Hospital of Harbin Medical University, 150 Haping Road, Nangang District, Harbin, 150081, China.
authors.forename: Hongyu
authors.initials: H
authors.lastname: Gao
authors.affiliation: Department of Gastroenterological Surgery, The Affiliated Tumor Hospital of Harbin Medical University, 150 Haping Road, Nangang District, Harbin, 150081, China.
authors.forename: Sen
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Hematology, The Affiliated Tumor Hospital of Harbin Medical University, Harbin, China.
authors.forename: Lina
authors.initials: L
authors.lastname: Quan
authors.affiliation: Department of Pathology, The Affiliated Tumor Hospital of Harbin Medical University, Harbin, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Department of Pathology, The Affiliated Tumor Hospital of Harbin Medical University, Harbin, China.
authors.forename: Shaohua
authors.initials: S
authors.lastname: Ding
authors.affiliation: Department of Gastroenterological Surgery, The Affiliated Tumor Hospital of Harbin Medical University, 150 Haping Road, Nangang District, Harbin, 150081, China. xueyingwei@hrbmu.edu.cn.
authors.forename: Yingwei
authors.initials: Y
authors.lastname: Xue
mesh_terms: D000368:Aged; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D011379:Prognosis; D051140:Selenoproteins / Q000096:biosynthesis*; D013274:Stomach Neoplasms / Q000097:blood* / Q000175:diagnosis
chemical_list: D009363:Neoplasm Proteins; D051140:Selenoproteins
keywords: Gastric cancer; Human; Selenium; Selenoproteins