title: The sesquiterpene α-bisabolol in the adipocyte-cancer desmoplastic crosstalk: does it have an action on epithelial-mesenchymal transition mechanisms?
abstract: Alpha-bisabolol is a plant-derived sesquiterpene alcohol recently associated with a supposed anti-cancer action due to its ability to induce BID-related apoptosis. The molecule, which enters the cell through lipid rafts, may also interact with kisspeptin receptor 1, which has recently been associated with tumor mobility and invasiveness. This evidence suggests the possibility that α-bisabolol might act on the epithelial-mesenchymal transition mechanism, closely associated with the desmoplastic reaction of adipose tissue surrounding a pancreatic ductal adenocarcinoma. This review addresses the issue on the basis of the most recent reported literature in the field.
authors.affiliation: Department of Neurological and Movement Sciences, University of Verona, Strada Le Grazie 9, Verona, Italy. salvatore.chirumbolo@univr.it.|CONEM Scientific Secretary, Mo i Rana, Norway. salvatore.chirumbolo@univr.it.
authors.forename: Salvatore
authors.identifier: http://orcid.org/0000-0003-1789-8307
authors.initials: S
authors.lastname: Chirumbolo
authors.affiliation: Council for Nutritional and Environmental Medicine, Mo i Rana, Norway.
authors.forename: Geir
authors.initials: G
authors.lastname: Bjørklund
mesh_terms: D017667:Adipocytes / Q000187:drug effects* / Q000473:pathology; D021441:Carcinoma, Pancreatic Ductal / Q000188:drug therapy* / Q000473:pathology; D058750:Epithelial-Mesenchymal Transition / Q000187:drug effects*; D006801:Humans; D000081222:Monocyclic Sesquiterpenes; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D012717:Sesquiterpenes / Q000627:therapeutic use*; D059016:Tumor Microenvironment / Q000187:drug effects*
chemical_list: D000081222:Monocyclic Sesquiterpenes; D012717:Sesquiterpenes; C004497:bisabolol
keywords: Adipocyte; Alpha-bisabolol; EMT mechanism; Pancreas cancer