title: [The Basic-Symptom Concept and its Influence on Current International Research on the Prediction of Psychoses].
abstract: The early detection of psychoses has become increasingly relevant in research and clinic. Next to the ultra-high risk (UHR) approach that targets an immediate risk of developing frank psychosis, the basic symptom approach that targets the earliest possible detection of the developing disorder is being increasingly used worldwide. The present review gives an introduction to the development and basic assumptions of the basic symptom concept, summarizes the results of studies on the specificity of basic symptoms for psychoses in different age groups as well as on studies of their psychosis-predictive value, and gives an outlook on future results. Moreover, a brief introduction to first recent imaging studies is given that supports one of the main assumptions of the basic symptom concept, i. e., that basic symptoms are the most immediate phenomenological expression of the cerebral aberrations underlying the development of psychosis. From this, it is concluded that basic symptoms might be able to provide important information on future neurobiological research on the etiopathology of psychoses.
authors.forename: F
authors.initials: F
authors.lastname: Schultze-Lutter
mesh_terms: D035843:Biomedical Research; D001921:Brain / Q000473:pathology; D003952:Diagnostic Imaging; D042241:Early Diagnosis; D006801:Humans; D007391:International Cooperation; D011618:Psychotic Disorders / Q000175:diagnosis* / Q000517:prevention & control / Q000523:psychology*; D012307:Risk Factors; D063189:Symptom Assessment