title: Application of graphene oxide-silica composite reinforced hollow fibers as a novel device for pseudo-stir bar solid phase microextraction of sulfadiazine in different matrices prior to its spectrophotometric determination.
abstract: This study presents a novel, simple and efficient pseudo-stir bar solid phase microextraction method for separation and preconcentration of sulfadiazine. To develop the method, a graphene oxide-silica composite reinforced hollow fiber was prepared via sol-gel technology and used as a novel device to extract sulfadiazine. The retained sulfadiazine was eluted using 180μL of methanol/acetic acid (6:4) and quantified by fiber optic linear array spectrophotometry based on the formation of its azo dye with thenoyltrifluoroacetone. Under optimized conditions, the method exhibited a linear dynamic range of 5-150μgL-1with a detection limit of 1.5μgL-1and an enrichment factor of 100. The relative standard deviations of 2.9% and 5.8% (n=6) were obtained at 60μgL-1level of sulfadiazine for intra- and inter-day analysis respectively. The method was successfully applied to determine sulfadiazine in honey, milk, human urine and environmental water samples.
authors.affiliation: Department of Chemistry, Yazd University, Safaieh, 89195-741 Yazd, Iran.
authors.forename: Elahe
authors.initials: E
authors.lastname: Kazemi
authors.affiliation: Department of Chemistry, Yazd University, Safaieh, 89195-741 Yazd, Iran.
authors.forename: Ali Mohammad
authors.initials: AM
authors.lastname: Haji Shabani
authors.affiliation: Department of Chemistry, Yazd University, Safaieh, 89195-741 Yazd, Iran. Electronic address: sdadfarnia@yazd.ac.ir.
authors.forename: Shayessteh
authors.initials: S
authors.lastname: Dadfarnia
mesh_terms: D006108:Graphite / Q000737:chemistry*; D006801:Humans; D057230:Limit of Detection; D010087:Oxides / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry*; D052617:Solid Phase Microextraction / Q000379:methods*; D013053:Spectrophotometry; D013411:Sulfadiazine / Q000302:isolation & purification*
chemical_list: D010087:Oxides; D013411:Sulfadiazine; D012822:Silicon Dioxide; D006108:Graphite
keywords: Diazotization; Fiber optic linear array spectrophotometry; Graphene oxide; Porous hollow fiber; Pseudo-stir bar solid-phase microextraction; Sulfadiazine