title: Consensus document for the use of the Polypill in the secondary prevention of cardiovascular disease.
abstract: Cardiovascular disease is a chronic disorder which is usually already at an advanced stage when the first symptoms develop. The fact that the initial clinical presentation can be lethal or highly incapacitating emphasizes the need for primary and secondary prevention. It is estimated that the ratio of patients with good adherence to secondary prevention of cardiovascular disease is low and also decreases gradually over time. The Polypill for secondary prevention of cardiovascular disease is the first fixed-dose combination therapy of salicylic acid, atorvastatin and ramipril approved in Spain. The purpose of this consensus document was to define and recommend, through the evidence available in the literature and clinical expert opinion, the impact of treatment adherence in the secondary prevention of cardiovascular disease and the use of the Polypill in daily clinical practice as part of a global strategy including adjustments in patient lifestyle. A RAND/UCLA methodology based on scientific evidence, as well as the collective judgment and clinical expertise of an expert panel was used for this assessment. As a result, a final report of recommendations on the impact of the lack of adherence to treatment of secondary prevention of cardiovascular disease and the effect of using a Polypill in adherence of patients was produced. The recommendations included in this document have been addressed to all those specialists, cardiologists, internists and primary care physicians with competence in prescribing and monitoring patients with high and very high cardiovascular risks.
authors.affiliation: Sociedad Española de Cardiología, Madrid, España. Electronic address: Jose.Ramon.Gonzalez.Juanatey@sergas.es.
authors.forename: José Ramón
authors.initials: JR
authors.lastname: González-Juanatey
authors.affiliation: Sociedad Española de Medicina Interna, Madrid, España.
authors.forename: José María
authors.initials: JM
authors.lastname: Mostaza
authors.affiliation: Sociedad Española de Medicina de Familia y Comunitaria, Barcelona, España.
authors.forename: José María
authors.initials: JM
authors.lastname: Lobos
authors.affiliation: Sociedad Española de Médicos Generales y de Familia, Madrid, España.
authors.forename: Benjamín
authors.initials: B
authors.lastname: Abarca
authors.affiliation: Sociedad Española de Médicos de Atención Primaria, Madrid, España.
authors.forename: José Luis
authors.initials: JL
authors.lastname: Llisterri
authors.affiliation: Sociedad Española de Cardiología, Madrid, España.
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Baron-Esquivias
authors.affiliation: Sociedad Española de Cardiología, Madrid, España.
authors.forename: Enrique
authors.initials: E
authors.lastname: Galve
authors.affiliation: Sociedad Española de Cardiología, Madrid, España.
authors.forename: Rosa María
authors.initials: RM
authors.lastname: Lidón
authors.affiliation: Sociedad Española de Cardiología, Madrid, España.
authors.forename: Francisco Xavier
authors.initials: FX
authors.lastname: Garcia-Moll
authors.affiliation: Sociedad Española de Cardiología, Madrid, España.
authors.forename: Pedro Luis
authors.initials: PL
authors.lastname: Sánchez
authors.affiliation: Sociedad Española de Medicina Interna, Madrid, España.
authors.forename: Carmen
authors.initials: C
authors.lastname: Suárez
authors.affiliation: Sociedad Española de Medicina Interna, Madrid, España.
authors.forename: Jesús
authors.initials: J
authors.lastname: Millán
authors.affiliation: Sociedad Española de Médicos de Atención Primaria, Madrid, España.
authors.forename: Vicente
authors.initials: V
authors.lastname: Pallares
authors.affiliation: Sociedad Española de Medicina de Familia y Comunitaria, Barcelona, España.
authors.forename: José Juan
authors.initials: JJ
authors.lastname: Alemán
authors.affiliation: Sociedad Española de Médicos Generales y de Familia, Madrid, España.
authors.forename: Isabel
authors.initials: I
authors.lastname: Egocheaga
mesh_terms: D000069059:Atorvastatin / Q000008:administration & dosage* / Q000627:therapeutic use; D002317:Cardiovascular Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000517:prevention & control*; D004338:Drug Combinations; D006801:Humans; D055118:Medication Adherence; D017257:Ramipril / Q000008:administration & dosage* / Q000627:therapeutic use; D020156:Salicylic Acid / Q000008:administration & dosage* / Q000627:therapeutic use; D055502:Secondary Prevention / Q000379:methods*
chemical_list: D002317:Cardiovascular Agents; D004338:Drug Combinations; D000069059:Atorvastatin; D017257:Ramipril; D020156:Salicylic Acid
keywords: Adherence; Adherencia; Cardiovascular disease; Combination therapy; Enfermedad cardiovascular; Polypill; Prevención; Prevention; Recomendaciones; Recommendations; Tratamiento combinado