title: Total Syntheses of Anti-HIV Cyclodepsipeptides Aetheramides A and B.
abstract: A concise total synthesis of aetheramide A in an overall yield of 4.7% with a longest linear sequence of 15 steps is described. This synthetic strategy features macrocyclization via an intramolecular trapping of acylketene generated from dioxinone precursor, and stereoselective late-stage methylation of β-ketoamide. Aetheramide B could be synthesized via the ester migration of aetheramide A.
authors.affiliation: School of Pharmaceutical Sciences and Innovative Drug Research Centre, Chongqing University , 55 Daxuecheng South Road, Shapingba, Chongqing 401331, P. R. China.
authors.forename: Na
authors.initials: N
authors.lastname: Qi
authors.affiliation: School of Pharmaceutical Sciences and Innovative Drug Research Centre, Chongqing University , 55 Daxuecheng South Road, Shapingba, Chongqing 401331, P. R. China.
authors.forename: Zhanlong
authors.initials: Z
authors.lastname: Wang
authors.affiliation: School of Pharmaceutical Sciences and Innovative Drug Research Centre, Chongqing University , 55 Daxuecheng South Road, Shapingba, Chongqing 401331, P. R. China.
authors.forename: Srinivasa Rao
authors.initials: SR
authors.lastname: Allu
authors.affiliation: School of Pharmaceutical Sciences and Innovative Drug Research Centre, Chongqing University , 55 Daxuecheng South Road, Shapingba, Chongqing 401331, P. R. China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Liu
authors.affiliation: School of Pharmaceutical Sciences and Innovative Drug Research Centre, Chongqing University , 55 Daxuecheng South Road, Shapingba, Chongqing 401331, P. R. China.
authors.forename: Jian
authors.initials: J
authors.lastname: Guo
authors.affiliation: School of Pharmaceutical Sciences and Innovative Drug Research Centre, Chongqing University , 55 Daxuecheng South Road, Shapingba, Chongqing 401331, P. R. China.
authors.forename: Yun
authors.identifier: 0000-0002-5322-7300
authors.initials: Y
authors.lastname: He
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D066241:Carbon-13 Magnetic Resonance Spectroscopy; D003500:Cyclization; D047630:Depsipeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008745:Methylation; D066244:Proton Magnetic Resonance Spectroscopy; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D019380:Anti-HIV Agents; D047630:Depsipeptides; C574677:aetheramide A; C574678:aetheramide B