title: Double-stranded RNA-dependent protein kinase signalling and paradigms of cardiometabolic syndrome.
abstract: Metabolic syndrome (Met S) is a collection of the most severe cardiometabolic risk factors that encompasses raised fasting plasma glucose, dyslipidaemia, insulin resistance, obesity and hypertension. The precise mechanism underlying the pathogenesis of Met S remains unclear. More often oxidative stress, inflammation and apoptosis are implicated in its aetiology. Recently, double-stranded RNA-dependent protein kinase has been found to intersect at the cross-road of oxidative stress, inflammation and apoptosis in several metabolic diseases. Therefore, an effort has been made in the present review to discuss the role of double-stranded RNA-dependent protein kinase and above-mentioned mechanisms in the progression of Met S, along with its interlinking in major clinical manifestations of Met S such as hypertension and diabetic cardiomyopathy.
authors.affiliation: Department of Pharmacy, Birla Institute of Technology and Sciences Pilani, Hyderabad Campus, Jawahar Nagar, Shameerpet, Hyderabad, Andhra Pradesh, 500078, India.
authors.forename: Jaspreet
authors.initials: J
authors.lastname: Kalra
authors.affiliation: Department of Pharmacy, Birla Institute of Technology and Sciences Pilani, Hyderabad Campus, Jawahar Nagar, Shameerpet, Hyderabad, Andhra Pradesh, 500078, India.
authors.forename: Arti
authors.initials: A
authors.lastname: Dhar
mesh_terms: D000818:Animals; D006801:Humans; D024821:Metabolic Syndrome / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D011494:Protein Kinases / Q000378:metabolism*; D012330:RNA, Double-Stranded / Q000378:metabolism*; D012307:Risk Factors
chemical_list: D012330:RNA, Double-Stranded; D011494:Protein Kinases
keywords: apoptosis; diabetic cardiomyopathy; double-stranded RNA-dependent protein kinase; hypertension; inflammation; metabolic syndrome; oxidative stress