title: Comparative evaluation of platelet-rich fibrin and autogenous bone graft for the treatment of infrabony defects in chronic periodontitis: Clinical, radiological, and surgical reentry.
abstract: BACKGROUND
  Both intraoral autogenous bone grafting (ABG) and platelet-rich fibrin (PRF) offer a useful treatment modality for periodontal regeneration of intrabony defects (IBDs). However, predictable regeneration in patients with severe attachment loss is a challenge to the practitioners.
  
  
  OBJECTIVE
  The aim of this study was to compare the clinical efficacy of PRF with ABG for the treatment of IBDs in chronic periodontitis.
  
  
  METHODS
  This is a randomized controlled trial.
  
  
  METHODS
  Twenty chronic periodontitis patients with IBDs were randomly treated by PRF or ABG. Probing pocket depth (PPD), relative attachment level (RAL), surgical reentry bone fill, and radiographic bone fill (RBF) were recorded at baseline, 3, 6, and 9 months postsurgery, respectively.
  
  
  METHODS
  Student's t-test was used for continuous variables. All means were expressed as mean ± standard deviation and proportions were expressed in percentage. The level of significance was set at P < 0.05.
  
  
  RESULTS
  Both PRF and ABG sites produced a significant improvement from baseline to 9 months for all the parameters. However, there was no significant difference between the two treatment modalities in the reduction of PPD and RAL gain at 9 months. In addition, ABG showed significantly greater RBF (30.34%) as compared to PRF (20.22%). Similar findings were supported by surgical reentry, where a surgical reentry of 65.31% at ABG sites and 43.64% at PRF sites was seen.
  
  
  CONCLUSIONS
  Both ABG and PRF can be used predictably to reconstruct lost periodontal structures as indicated by PPD reduction and RAL gain. However, in terms of osseous defect fill, ABG yields more definitive outcome than PRF.
authors.affiliation: Department of Periodontology, Daswani Dental College and Research Centre, Kota, Rajasthan, India.
authors.forename: Sneha
authors.initials: S
authors.lastname: Galav
authors.affiliation: Department of Periodontology, Hitkarini Dental College and Hospital, Jabalpur, Madhya Pradesh, India.
authors.forename: Kabbur Thippanna
authors.initials: KT
authors.lastname: Chandrashekar
authors.affiliation: Department of Periodontology, Hitkarini Dental College and Hospital, Jabalpur, Madhya Pradesh, India.
authors.forename: Rohit
authors.initials: R
authors.lastname: Mishra
authors.affiliation: Department of Periodontology, Hitkarini Dental College and Hospital, Jabalpur, Madhya Pradesh, India.
authors.forename: Vandana
authors.initials: V
authors.lastname: Tripathi
authors.affiliation: Department of Periodontology, Hitkarini Dental College and Hospital, Jabalpur, Madhya Pradesh, India.
authors.forename: Richa
authors.initials: R
authors.lastname: Agarwal
authors.affiliation: Department of Prosthodontics, Daswani Dental College and Research Centre, Kota, Rajasthan, India.
authors.forename: Ankit
authors.initials: A
authors.lastname: Galav
mesh_terms: D016301:Alveolar Bone Loss / Q000000981:diagnostic imaging / Q000601:surgery; D016025:Bone Transplantation; D055113:Chronic Periodontitis / Q000000981:diagnostic imaging / Q000601:surgery*; D005337:Fibrin / Q000627:therapeutic use*; D006801:Humans; D017622:Periodontal Attachment Loss / Q000000981:diagnostic imaging / Q000601:surgery; D053657:Platelet-Rich Plasma; D011861:Radiography, Dental; D016896:Treatment Outcome
chemical_list: D005337:Fibrin