title: Evaluation of inner segment/outer segment junctions in different types of epiretinal membranes.
abstract: This study was conducted to evaluate the relationships of inner/outer segment (IS/OS) junction disruption, macular thickness, and epiretinal membrane (ERM) grade with best-corrected visual acuity (BCVA), as well as the relationship between IS/OS junction disruption and ERM grade.
  Fifty-four eyes of 54 patients with different grades of ERM were retrospectively reviewed. Patients were classified into three groups by ERM grade according to retinal striae and vessel distortion: grade/group 1, visible membranes without retinal striae or vessel distortion; grade/group 2, mild to moderate macular striae or vessel straightening; and grade/group 3, moderate to severe striae and vascular straightening. Correlations of BCVA with age, central retinal thickness, ERM grade, and IS/OS disruption as well as of IS/OS disruption, central macular thickness, and BCVA with ERM grade were evaluated.
  Twenty-nine (53.7%) eyes exhibited IS/OS junction disruption. Groups 1 and 2 differed significantly with respect to BCVA (p=0.038), but groups 2 and 3 did not (p=0.070). Central macular thickness was significantly greater in group 2 than in group 1 (p=0.031) and in group 3 than in group 2 (p=0.033). Groups 1 and 2 differed significantly in terms of IS/OS disruption (p=0.000), but groups 2 and 3 did not (p=0.310).
  The IS/OS junction appears to be disrupted during the early stages of ERM. Grade 3 ERM is associated with a significantly higher incidence of IS/OS disruption.
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, Medipol University, Istanbul, Turkey.
authors.forename: Rukiye
authors.initials: R
authors.lastname: Aydın
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, Sifa University, Izmir, Turkey.
authors.forename: Eyyup
authors.initials: E
authors.lastname: Karahan
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.
authors.forename: Mahmut
authors.initials: M
authors.lastname: Kaya
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.
authors.forename: Taylan
authors.initials: T
authors.lastname: Ozturk
authors.affiliation: Department of Ophthalmology, Bağcılar Training and Research Hospital, Istanbul, Turkey.
authors.forename: Kubra Serefoglu
authors.initials: KS
authors.lastname: Cabuk
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.
authors.forename: Nilufer
authors.initials: N
authors.lastname: Kocak
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.
authors.forename: Suleyman
authors.initials: S
authors.lastname: Kaynak
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D019773:Epiretinal Membrane / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D006801:Humans; D016014:Linear Models; D008266:Macula Lutea / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D055211:Retinal Photoreceptor Cell Inner Segment / Q000473:pathology*; D055214:Retinal Photoreceptor Cell Outer Segment / Q000473:pathology*; D012189:Retrospective Studies; D012720:Severity of Illness Index; D041623:Tomography, Optical Coherence / Q000379:methods; D014792:Visual Acuity