title: Synthesis, antibacterial and antimutagenic activity of zerumbone-bicarbonyl analogues.
abstract: Synthesis of new zerumbone-bicarbonyl analogues by SeO2oxidation is reported. Selective oxidation of methyl at C-13 to an aldehyde and a ketone with exo-cyclic double bond between C-13 and C-6 in zerumbone has been recognized. Both these compounds have an additional conjugated-carbonyl-functionality. They exhibited significantly higher antimutagenic activity than zerumbone against Salmonella tester strains. They are more active against Gram positive bacteria than Gram negative bacteria; however zerumbone showed highest activity against E. coli, whereas its derivatives were least effective against E. coli.
authors.affiliation: Spice and Flavour Science Department, CSIR-Central Food Technological Research Institute, Mysuru 570 020, India.
authors.forename: S C
authors.initials: SC
authors.lastname: Santosh Kumar
authors.affiliation: Fruit and Vegetable Technology, CSIR-Central Food Technological Research Institute, Mysuru 570 020, India.
authors.forename: P S
authors.initials: PS
authors.lastname: Negi
authors.affiliation: Spice and Flavour Science Department, CSIR-Central Food Technological Research Institute, Mysuru 570 020, India.
authors.forename: J R
authors.initials: JR
authors.lastname: Manjunatha
authors.affiliation: Spice and Flavour Science Department, CSIR-Central Food Technological Research Institute, Mysuru 570 020, India. Electronic address: bettadaiah@cftri.res.in.
authors.forename: B K
authors.initials: BK
authors.lastname: Bettadaiah
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D064588:Selenium Oxides / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D064588:Selenium Oxides; D012717:Sesquiterpenes; C403304:zerumbone
keywords: Anti-mutagenic activity; Antibacterial activity; Selenium dioxide; Zerumbal; Zerumbenone