title: Early Postnatal Seizures in a Neonate with Wolf-Hirschhorn Syndrome.
abstract: BackgroundWolf-Hirschhorn syndrome (WHS), which is characterized by a typical facial appearance, growth retardation, mental retardation, seizures, and congenital cardiac defects, has an estimated incidence of 1 per 50,000 births.CaseWe report a case of a low birth weight neonate with WHS and seizures, as well as persistent pulmonary hypertension in the early neonatal period. Apgar scores were 6 (1 minute) and 8 (5 minutes) with evident retraction. After admission to the neonatal intensive care unit, the patient had tonic-clonic seizures with epilepticus 30 minute after birth. Although the seizures were uncontrollable, continuous thiopental administration was effective for seizure mitigation.ConclusionNeonatal seizures with WHS occur rarely. This is the first case report on seizures just after birth in a neonate with WHS.
authors.affiliation: Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan.
authors.forename: Hayato
authors.initials: H
authors.lastname: Go
authors.affiliation: Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Haneda
authors.affiliation: Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan.
authors.forename: Hajime
authors.initials: H
authors.lastname: Maeda
authors.affiliation: Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan.
authors.forename: Kei
authors.initials: K
authors.lastname: Ogasawara
authors.affiliation: Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Imamura
authors.affiliation: Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan.
authors.forename: Nobuo
authors.initials: N
authors.lastname: Momoi
authors.affiliation: Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan.
authors.forename: Mitsuaki
authors.initials: M
authors.lastname: Hosoya
keywords: Wolf–Hirschhorn syndrome; neonate; persistent pulmonary hypertension; seizure