title: Combined Counterclockwise Maxillomandibular Advancement and Uvulopalatopharyngoplasty Surgeries for Severe Obstructive Sleep Apnea.
abstract: As the most effective surgical technique maxillomandibular advancement (MMA) has been used to treat severe obstructive sleep apnea (OSA) in adults, particularly for those who are intolerant of continuous positive airway pressure. Yet for large-scale advancement, it is faced with esthetic problems with marked skeletal protrusion especially for people with convex facial profile. In this study, the authors performed counterclockwise MMA combined with quantified uvulopalatopharyngoplasty (UPPP) surgeries on Chinese adult patients with severe OSA, in order to initially explore the efficacy of these procedures on Chinese populations and provide evidence for esthetic advantages. As the primary procedure counterclockwise MMA was applied on 10 patients, achieving a forward distance of the mandible and the maxilla for 10.6 and 6.7 mm, respectively, and the occlusion plane rotated counterclockwise of 6.2°. After a follow-up of beyond 12 months, polysomnography results showed the apnea-hypopnea index (AHI) significantly decreased from 64.3 to 11.0 per hour, achieving surgical success of 90%. Upper airway measurements demonstrated that the retropalatal and retrolingual spaces got enlarged greatly, resulting in significant AHI reduction and oxygen saturation elevation. More importantly, cephalometric analysis revealed that SNA and SNB were enlarged but in well control without visual abnormalities. Follow-up results showed large-scale advancement of the maxilla and mandible were stable in treating severe OSA. Quantified UPPP surgeries guaranteed no functional insufficiency in pronouncing and swallowing and played auxiliary role in enlarging the upper airway. Thus, procedures of counterclockwise MMA combined with quantified UPPP surgeries might find more application especially in patients with severe OSA with convex facial profile in future.
authors.affiliation: *Department of Oral and Craniomaxillofacial Sciences, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine †Department of Oral and Maxillofacial Surgery, Shanghai Stomatological Disease Center ‡Department of Stomatology, Tenth People's Hospital, Tong Ji University School of Medicine, Shanghai, China.
authors.forename: Wenwen
authors.initials: W
authors.lastname: Yu
authors.forename: Meng
authors.initials: M
authors.lastname: Wang
authors.forename: Jiande
authors.initials: J
authors.lastname: He
authors.forename: Liyan
authors.initials: L
authors.lastname: Lu
authors.forename: Ming
authors.initials: M
authors.lastname: Cai
authors.forename: Hongxia
authors.initials: H
authors.lastname: Sun
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Lu
mesh_terms: D000328:Adult; D002508:Cephalometry / Q000379:methods; D002681:China; D045422:Continuous Positive Airway Pressure; D005260:Female; D006801:Humans; D008297:Male; D008334:Mandible / Q000601:surgery*; D019186:Mandibular Advancement / Q000379:methods*; D008437:Maxilla / Q000601:surgery*; D013517:Otorhinolaryngologic Surgical Procedures / Q000379:methods*; D010043:Outcome and Process Assessment, Health Care; D010609:Pharyngeal Muscles / Q000601:surgery*; D017286:Polysomnography / Q000379:methods; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000175:diagnosis / Q000601:surgery; D016896:Treatment Outcome; D014609:Uvula / Q000601:surgery*