title: A Palladium-Catalyzed Asymmetric Allylic Alkylation Approach to α-Quaternary γ-Butyrolactones.
abstract: The Pd-catalyzed asymmetric allylic alkylation (Pd-AAA) of enol carbonates derived from γ-butyrolactones is reported, affording the corresponding enantioenriched α,α'-disubstituted γ-butyrolactones in both high yields and high enantioselectivities (up to 94% ee). This method was eventually applied to the synthesis of chiral spirocyclic compounds.
authors.affiliation: Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation (CBI) - ESPCI Paris/CNRS (UMR8231), PSL Research University , 10 rue Vauquelin, 75231 Paris Cedex 05, France.
authors.forename: Marllon
authors.initials: M
authors.lastname: Nascimento de Oliveira
authors.affiliation: Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation (CBI) - ESPCI Paris/CNRS (UMR8231), PSL Research University , 10 rue Vauquelin, 75231 Paris Cedex 05, France.
authors.forename: Jeremy
authors.initials: J
authors.lastname: Fournier
authors.affiliation: Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation (CBI) - ESPCI Paris/CNRS (UMR8231), PSL Research University , 10 rue Vauquelin, 75231 Paris Cedex 05, France.
authors.forename: Stellios
authors.identifier: 0000-0001-6831-2631
authors.initials: S
authors.lastname: Arseniyadis
authors.affiliation: Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation (CBI) - ESPCI Paris/CNRS (UMR8231), PSL Research University , 10 rue Vauquelin, 75231 Paris Cedex 05, France.
authors.forename: Janine
authors.initials: J
authors.lastname: Cossy