title: Frequency of Nerve Root Sleeve Cysts in Autosomal Dominant Polycystic Kidney Disease.
abstract: BACKGROUND
  There is sporadic data about the occurrence of spinal meningeal cysts in patients with autosomal dominant polycystic kidney disease (ADPKD). We suggest that there is a relationship with the frequency and size of spinal meningeal cysts and headache, intracranial aneurysms, and cerebrospinal fluid leakage in patients with ADPKD.
  
  
  OBJECTIVE
  To investigate the relationship with spinal meningeal cyst, cerebrospinal fluid leakage, and headache in patients with ADPKD.
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  We enrolled 50 patients with ADPKD and 37 healthy volunteers. This cross-sectional study included patients with ADPKD and matched healthy volunteers. Magnetic resonance imaging myelography was performed using the 3D-T2 HASTE technique in an MRI scanner. We questioned our subjects regarding presence of headache and evaluated headache severity using a visual analog scale. The relationship between the number and size of spinal meningeal cysts with headache, intracranial aneurysms, and liver cysts was also investigated.
  
  
  RESULTS
  Spinal meningeal cysts were more numerous and larger in patients than in controls (14.8±11.6 vs. 6.4±4.6 cysts respectively, p<0.001, 68.3±49.3 vs. 25.4±20.1 mm, p<0.001, respectively). Spinal cyst number and size were similar in APDKD patients with or without intracranial aneurysms. Headache score was correlated with the size and number of spinal meningeal cysts. This was valid only in patients with ADPKD.
  
  
  CONCLUSIONS
  Abnormality involving the vessel wall in ADPKD may explain the increased number of spinal meningeal cysts in ADPKD. Moreover, leakage of cerebrospinal fluid secondary to spinal meningeal cyst may be responsible for recurrent severe headache by causing spontaneous intracranial hypotension in these patients.
authors.affiliation: Department of Radiology, İstanbul University Cerrahpaşa School of Medicine, İstanbul, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Aşık
authors.affiliation: Department of Internal Medicine, İstanbul University İstanbul School of Medicine, İstanbul, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Tufan
authors.affiliation: Department of Internal Medicine, İstanbul University İstanbul School of Medicine, İstanbul, Turkey.
authors.forename: Timur Selçuk
authors.initials: TS
authors.lastname: Akpınar
authors.affiliation: Department of Internal Medicine, İstanbul University Cerrahpaşa School of Medicine, İstanbul, Turkey.
authors.forename: Nilgül
authors.initials: N
authors.lastname: Akalın
authors.affiliation: Department of Mathematics, Koç University, İstanbul, Turkey.
authors.forename: Elvan
authors.initials: E
authors.lastname: Ceyhan
authors.affiliation: Department of Radiology, İstanbul University Cerrahpaşa School of Medicine, İstanbul, Turkey.
authors.forename: Necmeddin
authors.initials: N
authors.lastname: Tunç
authors.affiliation: Department of Radiology, İstanbul University Cerrahpaşa School of Medicine, İstanbul, Turkey.
authors.forename: Zehra Işık
authors.initials: ZI
authors.lastname: Hasıloğlu
authors.affiliation: Department of Internal Medicine, İstanbul University Cerrahpaşa School of Medicine, İstanbul, Turkey.
authors.forename: Mehmet Rıza
authors.initials: MR
authors.lastname: Altıparmak
authors.affiliation: Department of Internal Medicine, İstanbul University İstanbul School of Medicine, İstanbul, Turkey.
authors.forename: Tevfik
authors.initials: T
authors.lastname: Ecder
authors.affiliation: Department of Radiology, İstanbul University Cerrahpaşa School of Medicine, İstanbul, Turkey.
authors.forename: Sait
authors.initials: S
authors.lastname: Albayram
keywords: Spinal meningeal cysts; autosomal dominant polycystic kidney disease; headache