title: Coupling between One-Dimensional Networks Reconciles Conflicting Dynamics in LIP and Reveals Its Recurrent Circuitry.
abstract: Little is known about the internal circuitry of the primate lateral intraparietal area (LIP). During two versions of a delayed-saccade task, we found radically different network dynamics beneath similar population average firing patterns. When neurons are not influenced by stimuli outside their receptive fields (RFs), dynamics of the high-dimensional LIP network during slowly varying activity lie predominantly in one multi-neuronal dimension, as described previously. However, when activity is suppressed by stimuli outside the RF, slow LIP dynamics markedly deviate from a single dimension. The conflicting results can be reconciled if two LIP local networks, each underlying an RF location and dominated by a single multi-neuronal activity pattern, are suppressively coupled to each other. These results demonstrate the low dimensionality of slow LIP local dynamics, and suggest that LIP local networks encoding the attentional and movement priority of competing visual locations actively suppress one another.
authors.affiliation: Doctoral Program in Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA; Center for Theoretical Neuroscience, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA; Department of Neuroscience, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. Electronic address: zhang_wujie@hotmail.com.
authors.forename: Wujie
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Doctoral Program in Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA; Department of Neuroscience, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA; Mahoney Center for Brain and Behavior, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA; New York State Psychiatric Institute, New York, NY 10032, USA; Institute of Neuroscience, New York University School of Medicine, New York, NY 10016, USA.
authors.forename: Annegret L
authors.initials: AL
authors.lastname: Falkner
authors.affiliation: Department of Neuroscience, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA; Mahoney Center for Brain and Behavior, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA; New York State Psychiatric Institute, New York, NY 10032, USA; Cognitive Neuroscience Laboratory, German Primate Center - Leibniz Institute for Primate Research, 37077 Goettingen, Germany.
authors.forename: B Suresh
authors.initials: BS
authors.lastname: Krishna
authors.affiliation: Department of Neuroscience, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA; Kavli Institute for Brain Science, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA; Mahoney Center for Brain and Behavior, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA; Departments of Neurology, Psychiatry, and Ophthalmology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA; New York State Psychiatric Institute, New York, NY 10032, USA.
authors.forename: Michael E
authors.initials: ME
authors.lastname: Goldberg
authors.affiliation: Center for Theoretical Neuroscience, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA; Department of Neuroscience, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA; Swartz Program in Theoretical Neuroscience, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA; Kavli Institute for Brain Science, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
authors.forename: Kenneth D
authors.initials: KD
authors.lastname: Miller
mesh_terms: D000818:Animals; D001288:Attention / Q000502:physiology*; D008253:Macaca mulatta; D008959:Models, Neurological; D009068:Movement; D009415:Nerve Net; D009474:Neurons / Q000502:physiology*; D010296:Parietal Lobe / Q000502:physiology*; D012438:Saccades / Q000502:physiology*
keywords: LIP; attention; model; network dynamics; surround suppression