title: Dihydromyricetin delays the onset of hyperglycemia and ameliorates insulin resistance without excessive weight gain in Zucker diabetic fatty rats.
abstract: Many flavonoids are reported to be partial agonists of PPARγ and exert antidiabetic effects with fewer side effects compared with full agonists. Here, we assessed the effects of flavonoid dihydromyricetin (DHM) on glucose homeostasis in male Zucker diabetic fatty rats. Animals were treated with DHM (50-200  mg kg-1) or rosiglitazone (4  mg kg-1) once a day for 8 weeks. We found that DHM reduced fasting blood glucose and delayed the onset of hyperglycemia by 4 weeks. Furthermore, DHM preserved pancreatic β-cell mass, elevated adiponectin and improved lipid profile more vigorously than rosiglitazone. Notably, DHM decreased body weight gain and fat accumulation in both liver and adipose tissue, while rosiglitazone caused a significant increase of body weight and fat accumulation. DHM inhibited phosphorylation of PPARγ at serine 273 more efficiently than rosiglitazone. These results suggest that DHM exerts antidiabetic effects without causing excessive body weight gain via inhibition of PPARγ phosphorylation.
authors.affiliation: Research Center for Nutrition and Food Safety, Chongqing Key Laboratory of Nutrition and Food Safety, Institute of Military Preventive Medicine, Third Military Medical University, Chongqing, China. Electronic address: liuleililian@tmmu.edu.cn.
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
authors.affiliation: Research Center for Nutrition and Food Safety, Chongqing Key Laboratory of Nutrition and Food Safety, Institute of Military Preventive Medicine, Third Military Medical University, Chongqing, China. Electronic address: wanjing1986@yeah.net.
authors.forename: Jing
authors.initials: J
authors.lastname: Wan
authors.affiliation: Research Center for Nutrition and Food Safety, Chongqing Key Laboratory of Nutrition and Food Safety, Institute of Military Preventive Medicine, Third Military Medical University, Chongqing, China. Electronic address: lang0401@163.com.
authors.forename: Hedong
authors.initials: H
authors.lastname: Lang
authors.affiliation: Research Center for Nutrition and Food Safety, Chongqing Key Laboratory of Nutrition and Food Safety, Institute of Military Preventive Medicine, Third Military Medical University, Chongqing, China. Electronic address: 13752914265@163.com.
authors.forename: Mingyu
authors.initials: M
authors.lastname: Si
authors.affiliation: Research Center for Nutrition and Food Safety, Chongqing Key Laboratory of Nutrition and Food Safety, Institute of Military Preventive Medicine, Third Military Medical University, Chongqing, China. Electronic address: zjdnfs@126.com.
authors.forename: Jundong
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Research Center for Nutrition and Food Safety, Chongqing Key Laboratory of Nutrition and Food Safety, Institute of Military Preventive Medicine, Third Military Medical University, Chongqing, China. Electronic address: zhouyong@tmmu.edu.cn.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Research Center for Nutrition and Food Safety, Chongqing Key Laboratory of Nutrition and Food Safety, Institute of Military Preventive Medicine, Third Military Medical University, Chongqing, China. Electronic address: mi_mt2009@hotmail.com.
authors.forename: Mantian
authors.initials: M
authors.lastname: Mi
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects* / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000378:metabolism / Q000473:pathology; D018450:Disease Progression; D044948:Flavonols / Q000494:pharmacology*; D006943:Hyperglycemia / Q000150:complications / Q000378:metabolism / Q000473:pathology* / Q000517:prevention & control; D007333:Insulin Resistance; D008297:Male; D009765:Obesity / Q000150:complications / Q000378:metabolism / Q000473:pathology; D051381:Rats; D011924:Rats, Zucker; D013997:Time Factors; D015430:Weight Gain / Q000187:drug effects*
chemical_list: D001786:Blood Glucose; D044948:Flavonols; C472036:dihydromyricetin
keywords: Insulin resistance; Peroxisome proliferator-activated receptor γ; Type 2 diabetes; Zucker diabetic fatty rat