title: Patho-Histological Findings of Annular Rupture Related to Left Ventricular Outflow Tract (LVOT) Calcification Following Transcatheter Aortic Valve Replacement (TAVR).
abstract: Peri-aortic hematoma has been recently described as a potentially life-threatening complication following transcatheter aortic valve replacement (TAVR). Patient- and procedure-related factors exist that predispose to peri-aortic hematoma formation, which can progress to myocardial rupture at the aortic root-myocardial junction. While conservative therapy with blood pressure control is the expectant management following peri-aortic hematoma formation, myocardial rupture can occur at the site of the aortic annulus. Hence, interventionists and echocardiologists must be prepared for emergent intervention to salvage the patient once the complication is recognized. The present report highlights the patho-histological findings related to left ventricular outflow tract calcification following TAVR.
authors.affiliation: Minneapolis Heart Institute at Abbott Northwestern Hospital, Minneapolis, MN, USA.
authors.forename: Ankur
authors.initials: A
authors.lastname: Kalra
authors.affiliation: Minneapolis Heart Institute at Abbott Northwestern Hospital, Minneapolis, MN, USA.
authors.forename: Wesley R
authors.initials: WR
authors.lastname: Pedersen
authors.affiliation: Jesse E. Edwards Registry of Cardiovascular Disease, United Hospital, St. Paul, MN, USA.
authors.forename: Shannon M
authors.initials: SM
authors.lastname: Mackey-Bojack
authors.affiliation: Jesse E. Edwards Registry of Cardiovascular Disease, United Hospital, St. Paul, MN, USA.
authors.forename: Emily R
authors.initials: ER
authors.lastname: Duncanson
authors.affiliation: Minneapolis Heart Institute at Abbott Northwestern Hospital, Minneapolis, MN, USA. Electronic correspondence: kharris@mplsheart.com.
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Harris
mesh_terms: D000369:Aged, 80 and over; D001021:Aortic Valve / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery*; D001024:Aortic Valve Stenosis / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D001706:Biopsy; D002114:Calcinosis / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D009202:Cardiomyopathies / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D017548:Echocardiography, Transesophageal; D006335:Heart Injuries / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D006350:Heart Valve Prosthesis; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000473:pathology*; D006406:Hematoma / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008297:Male; D011474:Prosthesis Design; D012307:Risk Factors; D014057:Tomography, X-Ray Computed; D065467:Transcatheter Aortic Valve Replacement / Q000009:adverse effects* / Q000295:instrumentation; D016896:Treatment Outcome