title: Synthesis of end-functionalized glycopolymers containing α(2,8) disialic acids via π-allyl nickel catalyzed coordinating polymerization and their interaction with Siglec-7.
abstract: An allene monomer containing an α(2,8) disialic acid was polymerized by a π-allyl nickel complex with an azido group to produce end-functional glycopolymers with an excellent polydispersity index. The polymers allowed terminal modification with a fluorescent dye by click chemistry. The glycopolymers can dissociate Siglec-7-GD3 interactions at low concentrations.
authors.affiliation: Department of Chemical Science and Engineering Tokyo Institute of Technology 2-12-1-H-101 Ookayama, Meguro, Tokyo 152-8552, Japan. thiroshi@apc.titech.ac.jp.
authors.forename: Shuichi
authors.initials: S
authors.lastname: Ohira
authors.affiliation: Bioscience and Biotechnology Center, Nagoya University Chikusa, Nagoya 464-8601, Japan.
authors.forename: Yu
authors.initials: Y
authors.lastname: Yasuda
authors.affiliation: Department of Chemical Science and Engineering Tokyo Institute of Technology 4259-G1-9, Nagatsuta-cho, Midori-ku, Yokohama 226-8502, Japan.
authors.forename: Ikuyoshi
authors.initials: I
authors.lastname: Tomita
authors.affiliation: Bioscience and Biotechnology Center, Nagoya University Chikusa, Nagoya 464-8601, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Kitajima
authors.affiliation: Yokohama University of Pharmacy 601, Matano-chou, Totsuka-ku, Yokohama, Kanagawa 245-0066, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Takahashi
authors.affiliation: Bioscience and Biotechnology Center, Nagoya University Chikusa, Nagoya 464-8601, Japan.
authors.forename: Chihiro
authors.initials: C
authors.lastname: Sato
authors.affiliation: Department of Chemical Science and Engineering Tokyo Institute of Technology 2-12-1-H-101 Ookayama, Meguro, Tokyo 152-8552, Japan. thiroshi@apc.titech.ac.jp.
authors.forename: Hiroshi
authors.identifier: 0000-0002-3661-9310
authors.initials: H
authors.lastname: Tanaka
mesh_terms: D015214:Antigens, Differentiation, Myelomonocytic / Q000737:chemistry; D002384:Catalysis; D057930:Click Chemistry; D005456:Fluorescent Dyes / Q000737:chemistry; D005732:Gangliosides / Q000037:antagonists & inhibitors* / Q000737:chemistry; D006801:Humans; D037102:Lectins / Q000037:antagonists & inhibitors* / Q000737:chemistry; D009532:Nickel / Q000737:chemistry*; D058105:Polymerization; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D012794:Sialic Acids / Q000737:chemistry*
chemical_list: D015214:Antigens, Differentiation, Myelomonocytic; D005456:Fluorescent Dyes; D005732:Gangliosides; D037102:Lectins; D011108:Polymers; C402206:SIGLEC7 protein, human; D012794:Sialic Acids; C026226:ganglioside, GD3; D009532:Nickel