title: Sequel of MgO nanoparticles in PLACL nanofibers for anti-cancer therapy in synergy with curcumin/β-cyclodextrin.
abstract: Pharmaceutical industries spend more money in developing new and efficient methods for delivering successful drugs for anticancer therapy. Electrospun nanofibers and nanoparticles loaded with drugs have versatile biomedical applications ranging from wound healing to anticancer therapy. We aimed to attempt for fabricating elastomeric poly (l-lactic acid-co-ε-caprolactone) (PLACL) with Aloe Vera (AV), magnesium oxide (MgO) nanoparticles, curcumin (CUR) and β-cyclodextrin (β-CD) composite nanofibers to control the growth of MCF-7 cells for breast cancer therapy. The study focused on the interaction of MgO nanoparticle with CUR and β-CD inhibiting the proliferation of Michigan Cancer Foundation-7 (MCF-7) breast cancer cells. FESEM micrographs of fabricated electrospun PLACL, PLACL/AV, PLACL/AV/MgO, PLACL/AV/MgO/CUR and PLACL/AV/MgO/β-CD nanofibrous scaffolds achieved bead free, random and uniform nanofibers with fiber diameter in the range of 786±286, 507±171, 334±95, 360±94 and 326±80nm respectively. Proliferation of MCF-7 cells was decreased by 65.92% in PLACL/AV/MgO/CUR with respect to PLACL/AV/MgO nanofibrous scaffolds on day 9. The obtained results proved that 1% CUR interacting with MgO nanoparticles showed higher inhibition of MCF-7 cells among all other nanofibrous scaffolds thus serving as a promising biocomposite material system for the breast cancer therapy.
authors.affiliation: Centre for Nanofibers & Nanotechnology, Mechanical Engineering, Faculty of Engineering, National University of Singapore, Singapore; The Centre for Nanotechnology Research, VIT University, Vellore, India.
authors.forename: Shruthi Vathaluru
authors.initials: SV
authors.lastname: Sudakaran
authors.affiliation: Centre for Nanofibers & Nanotechnology, Mechanical Engineering, Faculty of Engineering, National University of Singapore, Singapore. Electronic address: mpejrv@nus.edu.sg.
authors.forename: Jayarama Reddy
authors.initials: JR
authors.lastname: Venugopal
authors.affiliation: Centre for Nanofibers & Nanotechnology, Mechanical Engineering, Faculty of Engineering, National University of Singapore, Singapore.
authors.forename: Gnaneshwar Puvala
authors.initials: GP
authors.lastname: Vijayakumar
authors.affiliation: Centre for Nanofibers & Nanotechnology, Mechanical Engineering, Faculty of Engineering, National University of Singapore, Singapore; The Centre for Nanotechnology Research, VIT University, Vellore, India.
authors.forename: Sivasubramanian
authors.initials: S
authors.lastname: Abisegapriyan
authors.affiliation: The Centre for Nanotechnology Research, VIT University, Vellore, India.
authors.forename: Andrews Nirmala
authors.initials: AN
authors.lastname: Grace
authors.affiliation: Centre for Nanofibers & Nanotechnology, Mechanical Engineering, Faculty of Engineering, National University of Singapore, Singapore.
authors.forename: Seeram
authors.initials: S
authors.lastname: Ramakrishna
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D049109:Cell Proliferation / Q000187:drug effects; D003474:Curcumin / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D005260:Female; D006801:Humans; D061986:MCF-7 Cells; D017895:Manganese Compounds / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D057139:Nanofibers / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D010087:Oxides / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D011091:Polyesters / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D047392:beta-Cyclodextrins / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D017895:Manganese Compounds; D010087:Oxides; D011091:Polyesters; D047392:beta-Cyclodextrins; C550605:poly(lactic acid-co-epsilon-caprolactone); C027424:manganese oxide; D003474:Curcumin
keywords: Cancer therapy; Curcumin; Magnesium oxide; Nanofibers; Nanoparticles; β-Cyclodextrin