title: Discharge Disposition After Stroke in Patients With Liver Disease.
abstract: Liver disease is associated with both hemorrhagic and thrombotic processes, including an elevated risk of intracranial hemorrhage. We sought to assess the relationship between liver disease and outcomes after stroke, as measured by discharge disposition.
  
  
  
  Using administrative claims data, we identified a cohort of patients hospitalized with stroke in California, Florida, and New York from 2005 to 2013. The predictor variable was liver disease. All diagnoses were defined using validated diagnosis codes. Ordinal logistic regression was used to analyze the association between liver disease and worsening discharge disposition: home, nursing/rehabilitation facility, or death. Secondarily, multiple logistic regression was used to analyze the association between liver disease and in-hospital mortality. Models were adjusted for demographics, vascular risk factors, and comorbidities.
  
  
  
  We identified 121 428 patients with intracerebral hemorrhage and 703 918 with ischemic stroke. Liver disease was documented in 13 584 patients (1.7%). Liver disease was associated with worse discharge disposition after both intracerebral hemorrhage (global odds ratio, 1.28; 95% confidence interval, 1.19-1.38) and ischemic stroke (odds ratio, 1.23; 95% confidence interval, 1.17-1.29). Similarly, liver disease was associated with in-hospital death after both intracerebral hemorrhage (odds ratio, 1.33; 95% confidence interval, 1.23-1.44) and ischemic stroke (odds ratio, 1.60; 95% confidence interval, 1.51-1.71).
  
  
  
  Liver disease was associated with worse hospital discharge disposition and in-hospital mortality after stroke, suggesting worse functional outcomes.
authors.affiliation: From the Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute (N.S.P., A.E.M., B.B.N., H.K.), Department of Neurology (N.S.P., A.E.M., B.B.N., H.K.), and Division of Gastroenterology and Hepatology (Y.S.), Weill Cornell Medicine, New York, NY. nsp2001@nyp.org.
authors.forename: Neal S
authors.initials: NS
authors.lastname: Parikh
authors.affiliation: From the Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute (N.S.P., A.E.M., B.B.N., H.K.), Department of Neurology (N.S.P., A.E.M., B.B.N., H.K.), and Division of Gastroenterology and Hepatology (Y.S.), Weill Cornell Medicine, New York, NY.
authors.forename: Alexander E
authors.initials: AE
authors.lastname: Merkler
authors.affiliation: From the Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute (N.S.P., A.E.M., B.B.N., H.K.), Department of Neurology (N.S.P., A.E.M., B.B.N., H.K.), and Division of Gastroenterology and Hepatology (Y.S.), Weill Cornell Medicine, New York, NY.
authors.forename: Yecheskel
authors.initials: Y
authors.lastname: Schneider
authors.affiliation: From the Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute (N.S.P., A.E.M., B.B.N., H.K.), Department of Neurology (N.S.P., A.E.M., B.B.N., H.K.), and Division of Gastroenterology and Hepatology (Y.S.), Weill Cornell Medicine, New York, NY.
authors.forename: Babak B
authors.initials: BB
authors.lastname: Navi
authors.affiliation: From the Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute (N.S.P., A.E.M., B.B.N., H.K.), Department of Neurology (N.S.P., A.E.M., B.B.N., H.K.), and Division of Gastroenterology and Hepatology (Y.S.), Weill Cornell Medicine, New York, NY.
authors.forename: Hooman
authors.initials: H
authors.lastname: Kamel
mesh_terms: D000328:Adult; D015331:Cohort Studies; D005260:Female; D017052:Hospital Mortality / Q000639:trends; D006801:Humans; D008107:Liver Diseases / Q000175:diagnosis / Q000401:mortality* / Q000628:therapy*; D008297:Male; D010351:Patient Discharge / Q000592:standards* / Q000639:trends; D012189:Retrospective Studies; D012307:Risk Factors; D020521:Stroke / Q000175:diagnosis / Q000401:mortality* / Q000628:therapy*
keywords: : cerebral hemorrhage; liver cirrhosis; liver diseases; mortality; stroke