title: What Does The Blanking Period Blank?
abstract: In the management of paroxysmal, drug-refractory atrial fibrillation, pulmonary vein isolation has become a widely accepted treatment option. Currently, the arrhythmias following any form of myocardial ablation are not considered within a period of three months, known as "the blanking period". Although this period is authority- rather than evidence-based, it has become universally recognized. Indeed, several mechanisms play a role to determine the transient increased risk of post-procedural atrial tachyarrhythmias, occurring early after the procedure. Acute inflammatory changes may be responsible for immediate recurrence, since application of ablative energy on atrial tissue has a pro-inflammatory- and potentially arrhythmogenic effect. Atrial arrhythmias within the first 3 months after ablation are very common (35% to 65% of cases) and their significance as predictor of late recurrences is more significant during the first month. Furthermore, the current biological evidences indicate that the edema of the surrounding and ablated tissue is no longer present after 1 month. In our letter we advocate the reasons why a blanking period of four weeks should appear more reasonable, fostering its clinical importance and utility.
authors.affiliation: University of Groningen, University Medical Center Groningen, Cardio-Thoracic Surgery Department, Groningen, The Netherlands.
authors.forename: M A
authors.initials: MA
authors.lastname: Mariani
authors.affiliation: University of Groningen, University Medical Center Groningen, Cardio-Thoracic Surgery Department, Groningen, The Netherlands; San Raffaele University Hospital, Heart Surgery Unit, Milan, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Pozzoli
authors.affiliation: University of Groningen, University Medical Center Groningen, Cardio-Thoracic Surgery Department, Groningen, The Netherlands.
authors.forename: Ge De
authors.initials: G
authors.lastname: Maat
authors.affiliation: San Raffaele University Hospital, Heart Surgery Unit, Milan, Italy.
authors.forename: O R
authors.initials: OR
authors.lastname: Alfieri
authors.affiliation: University of Groningen, University Medical Center Groningen, Cardio-Thoracic Surgery Department, Groningen, The Netherlands.
authors.forename: S
authors.initials: S
authors.lastname: Benussi
keywords: Ablative Therapy; Atrial Fibrillation; Blanking Period; Pulmonary Veins Isolation