title: Enantiospecific tritium labeling of 28-homocastasterone.
abstract: A regiospecific and enantiospecific synthesis of tritium-labeled 28-homocastasterone is reported. Appropriate chlorocarbonate, efficiently synthesized from the starting 28-homocastasterone in an overall yield of 46%, undergoes catalytic tritium dechlorination by the T2/Pd[0]/Et3N system, providing 28-[3β-3H]homocastasterone, in a good yield, radiochemical purity (>97%), and with a high specific activity (5.8 Ci/mmol).
authors.affiliation: Radiosotope Laboratory, Institute of Organic Chemistry and Biochemistry, Prague, Czech Republic.
authors.forename: Tomáš
authors.initials: T
authors.lastname: Elbert
authors.affiliation: Radiosotope Laboratory, Institute of Organic Chemistry and Biochemistry, Prague, Czech Republic.
authors.forename: Mahadeo R
authors.initials: MR
authors.lastname: Patil
authors.affiliation: Radiosotope Laboratory, Institute of Organic Chemistry and Biochemistry, Prague, Czech Republic.
authors.forename: Aleš
authors.identifier: 0000-0001-9031-8263
authors.initials: A
authors.lastname: Marek
mesh_terms: D002384:Catalysis; D002778:Cholestanones / Q000737:chemistry*; D007553:Isotope Labeling; D013237:Stereoisomerism; D014316:Tritium / Q000737:chemistry*
chemical_list: D002778:Cholestanones; D014316:Tritium; C070164:homocastasterone
keywords: 28-homocastasterone; brassinosteroids; enantiospecific reaction; tritium dehalogenation; tritium labeling