title: Plasma free reversible and irreversible microfluidic bonding.
abstract: We demonstrate a facile, plasma free process to fabricate both reversibly and irreversibly sealed microfluidic chips using a PDMS-based adhesive polymer mixture. This is a versatile method that is compatible with current PDMS microfluidics processes. It allows for easier fabrication of multilayer microfluidic devices and is compatible with micropatterning of proteins for cell culturing. When combined with our Shrinky-Dink microfluidic prototyping, complete microfluidic device fabrication can be performed without the need for any capital equipment, making microfluidics accessible to the classroom.
authors.affiliation: Department of Biomedical Engineering, University of California, Irvine, CA 92697, USA. mkhine@uci.edu.
authors.forename: M
authors.initials: M
authors.lastname: Chu
authors.affiliation: Department of Chemical Engineering, University of California, Irvine, CA 92697, USA.
authors.forename: T T
authors.initials: TT
authors.lastname: Nguyen
authors.affiliation: Department of Biomedical Engineering, University of California, Irvine, CA 92697, USA. mkhine@uci.edu.
authors.forename: E K
authors.initials: EK
authors.lastname: Lee
authors.affiliation: Department of Biomedical Engineering, University of California, Irvine, CA 92697, USA. mkhine@uci.edu.
authors.forename: J L
authors.initials: JL
authors.lastname: Morival
authors.affiliation: Department of Biomedical Engineering, University of California, Irvine, CA 92697, USA. mkhine@uci.edu.
authors.forename: M
authors.initials: M
authors.lastname: Khine
mesh_terms: D000269:Adhesives; D004129:Dimethylpolysiloxanes; D006801:Humans; D056656:Lab-On-A-Chip Devices; D032383:Myocytes, Cardiac / Q000166:cytology; D011312:Pressure
chemical_list: D000269:Adhesives; D004129:Dimethylpolysiloxanes; C013830:baysilon