title: Autophagy-dependent danger signaling and adaptive immunity to poorly immunogenic tumors.
abstract: Recent data suggest that autophagy does not influence spontaneous and therapy-elicited tumor infiltration by immune cells in murine models of melanoma and breast carcinoma. These findings, which have been obtained in the absence of a therapeutically relevant anticancer immune response, indicate that the intrinsically low immunogenicity of some tumors cannot be compensated for by increased danger signaling.
authors.affiliation: Equipe 11 Labellisée par la Ligue Contre le Cancer, Centre de Recherche des Cordeliers, Paris, France.|INSERM, U1138, Paris, France.|Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France.|Université Pierre et Marie Curie/Paris VI, Paris, France.|Metabolomics and Cell Biology Platforms, Gustave Roussy Comprehensive Cancer Institute, Villejuif, France.|Pôle de Biologie, Hopitâl Européen George Pompidou, AP-HP, Paris, France.|Department of Women's and Children's Health, Karolinska University Hospital, Stockholm, Sweden.
authors.forename: Guido
authors.initials: G
authors.lastname: Kroemer
authors.affiliation: Equipe 11 Labellisée par la Ligue Contre le Cancer, Centre de Recherche des Cordeliers, Paris, France.|INSERM, U1138, Paris, France.|Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France.|Université Pierre et Marie Curie/Paris VI, Paris, France.|Gustave Roussy Comprehensive Cancer Institute, Villejuif, France.|Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Galluzzi
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D001343:Autophagy; D001943:Breast Neoplasms / Q000276:immunology*; D005260:Female; D006801:Humans; D008545:Melanoma / Q000276:immunology*; D051379:Mice; D015398:Signal Transduction
keywords: ATP; chloroquine; damage-associated molecular patterns; doxorubicin; immunogenic cell death; radiation therapy