title: Sequence Analysis of Toxin Gene-Bearing Corynebacterium diphtheriae Strains, Australia.
abstract: By conducting a molecular characterization of Corynebacterium diphtheriae strains in Australia, we identified novel sequences, nonfunctional toxin genes, and 5 recent cases of toxigenic cutaneous diphtheria. These findings highlight the importance of extrapharyngeal infections for toxin gene-bearing (functional or not) and non-toxin gene-bearing C. diphtheriae strains. Continued surveillance is recommended.
authors.forename: Christine J
authors.initials: CJ
authors.lastname: Doyle
authors.forename: Adam
authors.initials: A
authors.lastname: Mazins
authors.forename: Rikki M A
authors.initials: RM
authors.lastname: Graham
authors.forename: Ning-Xia
authors.initials: NX
authors.lastname: Fang
authors.forename: Helen V
authors.initials: HV
authors.lastname: Smith
authors.forename: Amy V
authors.initials: AV
authors.lastname: Jennison
mesh_terms: D001315:Australia / Q000453:epidemiology; D003353:Corynebacterium diphtheriae / Q000235:genetics / Q000472:pathogenicity*; D004165:Diphtheria / Q000453:epidemiology* / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control; D004167:Diphtheria Toxin / Q000096:biosynthesis / Q000235:genetics*; D004168:Diphtheria Toxoid / Q000008:administration & dosage; D062665:Epidemiological Monitoring; D005798:Genes, Bacterial; D006801:Humans; D035002:Lower Extremity / Q000382:microbiology / Q000473:pathology; D032541:Mass Vaccination; D009154:Mutation; D010614:Pharynx / Q000382:microbiology / Q000473:pathology; D012867:Skin / Q000382:microbiology / Q000473:pathology
chemical_list: D004167:Diphtheria Toxin; D004168:Diphtheria Toxoid
keywords: Corynebacterium diphtheriae; Corynebacterium infections; Diphtheria; bacteria; bacterial infections; diphtheria toxin; gram-positive bacterial infections; leg ulcer; skin diseases; wound infection