title: Responses to romidepsin by line of therapy in patients with relapsed or refractory peripheral T-cell lymphoma.
abstract: Peripheral T-cell lymphoma (PTCL) is a heterogeneous group of aggressive non-Hodgkin lymphomas typically associated with poor prognosis. Most patients with PTCL receive chemotherapy as first-line treatment, but many experience rapid relapse. For patients with relapsed/refractory PTCL, responses to treatment and long-term outcomes tend to worsen with increasing lines of therapy. Romidepsin is a potent class I histone deacetylase inhibitor approved by the US Food and Drug Administration for the treatment of PTCL in patients who have received ≥1 prior therapy. A pivotal phase 2 trial of romidepsin in patients with relapsed/refractory PTCL demonstrated an objective response rate of 25% (33/130), including 15% with confirmed/unconfirmed complete response, and a median duration of response of 28 months. In the analysis presented herein, romidepsin was shown to have similar responses and long-term outcomes in patients with 1, 2, and ≥3 prior lines of treatment, including in patients with disease refractory to the last prior therapy. Although adverse events increased with increasing lines of treatment, the rate of dose modifications and discontinuations due to adverse events was not significantly different. These data support the use of romidepsin as salvage treatment for PTCL irrespective of the number of prior therapies.
authors.affiliation: Yale Cancer Center, New Haven, Connecticut.
authors.forename: Francine
authors.initials: F
authors.lastname: Foss
authors.affiliation: Thomas Jefferson University, Philadelphia, Pennsylvania.
authors.forename: Barbara
authors.initials: B
authors.lastname: Pro
authors.affiliation: Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, Victoria, Australia.
authors.forename: H
authors.initials: H
authors.lastname: Miles Prince
authors.affiliation: Moffitt Cancer Center, Tampa, Florida.
authors.forename: Lubomir
authors.initials: L
authors.lastname: Sokol
authors.affiliation: Hospital Universitario de Salamanca, Salamanca, Spain.
authors.forename: Dolores
authors.initials: D
authors.lastname: Caballero
authors.affiliation: Memorial Sloan Kettering Cancer Center, New York, New York.
authors.forename: Steven
authors.initials: S
authors.lastname: Horwitz
authors.affiliation: Hospices Civils de Lyon, Lyon, France.
authors.forename: Bertrand
authors.initials: B
authors.lastname: Coiffier
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000627:therapeutic use; D047630:Depsipeptides / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D016411:Lymphoma, T-Cell, Peripheral / Q000188:drug therapy*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D000903:Antibiotics, Antineoplastic; D047630:Depsipeptides; C087123:romidepsin
keywords: HDAC inhibitor; peripheral T-cell lymphoma; refractory; romidepsin