title: Association between homocysteine and non-alcoholic fatty liver disease in Chinese adults: a cross-sectional study.
abstract: Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide, and its prevalence is likely to rise even further. To help understand the pathogenesis and early prevention of progressive NAFLD, this large-scale study was designed to explore the potential association between homocysteine and the prevalence of NAFLD.
  
  
  
  A total of 7203 subjects aged 18 years or older were enrolled in this cross-sectional study. The association of homocysteine with the prevalence of NAFLD, in the total sample and stratified by subgroups, was examined using multiple logistic regression analyses.
  
  
  
  Subjects in the higher quartiles of homocysteine had a higher prevalence of NAFLD. After multivariate adjustment, the odds ratio (OR) for NAFLD in the highest compared with the lowest quartile of homocysteine was 2.08 (95% confidence interval [CI] 1.61, 2.67). Moreover, in the subgroup analyses, we found an effect modification by gender, body mass index (BMI) and smoking status on the association between homocysteine and the prevalence of NAFLD (P for interaction: 0.001, 0.002 and <0.001, respectively). A stronger association was observed in female, obese and non-smoking adults than in male, normal weight and smoking subjects.
  
  
  
  Homocysteine was significantly associated with the prevalence of NAFLD, particularly in female, obese or non-smoking adults.
authors.affiliation: Center of Clinical Pharmacology, the Third Xiangya Hospital, Central South University, 138 Tong-Zi-Po Road, Changsha, Hunan, Zip 410013, People's Republic of China.|Center of Health Management, the Third Xiangya Hospital, Central South University, Changsha, Hunan Province, Zip 410013, People's Republic of China.
authors.forename: Haijiang
authors.initials: H
authors.lastname: Dai
authors.affiliation: Division of Gastroenterology, Union Hospital, Huazhong University of Science and Technology, Wuhan, Hubei Province, Zip 430022, People's Republic of China.
authors.forename: Weijun
authors.initials: W
authors.lastname: Wang
authors.affiliation: Center of Clinical Pharmacology, the Third Xiangya Hospital, Central South University, 138 Tong-Zi-Po Road, Changsha, Hunan, Zip 410013, People's Republic of China.
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Tang
authors.affiliation: Center of Clinical Pharmacology, the Third Xiangya Hospital, Central South University, 138 Tong-Zi-Po Road, Changsha, Hunan, Zip 410013, People's Republic of China.
authors.forename: Ruifang
authors.initials: R
authors.lastname: Chen
authors.affiliation: Center of Health Management, the Third Xiangya Hospital, Central South University, Changsha, Hunan Province, Zip 410013, People's Republic of China.
authors.forename: Zhiheng
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Center of Clinical Pharmacology, the Third Xiangya Hospital, Central South University, 138 Tong-Zi-Po Road, Changsha, Hunan, Zip 410013, People's Republic of China. luyao0719@hotmail.com.
authors.forename: Yao
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Center of Clinical Pharmacology, the Third Xiangya Hospital, Central South University, 138 Tong-Zi-Po Road, Changsha, Hunan, Zip 410013, People's Republic of China. yuanhong_xy3@163.com.
authors.forename: Hong
authors.initials: H
authors.lastname: Yuan
mesh_terms: D000328:Adult; D044466:Asian People; D015992:Body Mass Index; D002681:China; D002784:Cholesterol / Q000097:blood; D003404:Creatinine / Q000097:blood; D003430:Cross-Sectional Studies; D015444:Exercise; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000097:blood* / Q000453:epidemiology*; D009765:Obesity / Q000097:blood / Q000453:epidemiology*; D015995:Prevalence; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D014280:Triglycerides; D006710:Homocysteine; D002784:Cholesterol; D003404:Creatinine
keywords: Body mass index; Gender; Homocysteine; Interaction; Non-alcoholic fatty liver disease