title: Antimicrobial Oligophenalenone Dimers from the Soil Fungus Talaromyces stipitatus.
abstract: New polyketide-derived oligophenalenone dimers, 9a-epi-bacillisporin E (1) and bacillisporins F-H (2-5), along with the known bacillisporin A (6), were isolated from the fungus Talaromyces stipitatus. Their structures and absolute configurations were determined on the basis of spectroscopic analyses, electronic circular dichroism, and GIAO NMR shift calculation followed by DP4 analysis. The antimicrobial activity of these compounds was evaluated against a panel of human pathogenic bacteria. Among them, bacillisporin H (5) exhibited antimicrobial activity together with modest cytotoxicity against HeLa cells.
authors.affiliation: Unité Molécules de Communication et Adaptation des Micro-organismes (UMR 7245), Sorbonne Université, Muséum National d'Histoire Naturelle , CNRS, CP 54, 57 Rue Cuvier, 75005 Paris, France.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zang
authors.affiliation: C-TAC, UMR 8638 CNRS, Faculté des Sciences Pharmaceutiques et Biologiques, Paris Descartes University , Sorbonne Paris Cité, 4 Avenue de l'Observatoire, 75006 Paris, France.
authors.forename: Grégory
authors.initials: G
authors.lastname: Genta-Jouve
authors.affiliation: UPMC Univ Paris 06, INSERM, Laboratory of Cancer Biology and Therapeutics, Centre de Recherche Saint-Antoine (CRSA), Sorbonne Universités , UMR_S 938, F-75012 Paris, France.
authors.forename: Alexandre E
authors.initials: AE
authors.lastname: Escargueil
authors.affiliation: UPMC Univ Paris 06, INSERM, Laboratory of Cancer Biology and Therapeutics, Centre de Recherche Saint-Antoine (CRSA), Sorbonne Universités , UMR_S 938, F-75012 Paris, France.
authors.forename: Annette K
authors.initials: AK
authors.lastname: Larsen
authors.affiliation: Unité Molécules de Communication et Adaptation des Micro-organismes (UMR 7245), Sorbonne Université, Muséum National d'Histoire Naturelle , CNRS, CP 54, 57 Rue Cuvier, 75005 Paris, France.
authors.forename: Laura
authors.initials: L
authors.lastname: Guedon
authors.affiliation: Unité Molécules de Communication et Adaptation des Micro-organismes (UMR 7245), Sorbonne Université, Muséum National d'Histoire Naturelle , CNRS, CP 54, 57 Rue Cuvier, 75005 Paris, France.
authors.forename: Bastien
authors.initials: B
authors.lastname: Nay
authors.affiliation: Unité Molécules de Communication et Adaptation des Micro-organismes (UMR 7245), Sorbonne Université, Muséum National d'Histoire Naturelle , CNRS, CP 54, 57 Rue Cuvier, 75005 Paris, France.
authors.forename: Soizic
authors.identifier: http://orcid.org/0000-0002-8071-9642
authors.initials: S
authors.lastname: Prado
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D013293:Enterococcus faecalis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D043803:Phenalenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D012988:Soil Microbiology; D013211:Staphylococcus aureus / Q000187:drug effects; D032901:Talaromyces / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D043803:Phenalenes; C515799:bacillisporin E; C038036:phenalen-1-one