title: Rhabdomyosarcoma.
abstract: A malignant tumor of striated muscle origin, rhabdomyosarcoma (RMS) is a childhood tumor that has benefited from nearly 30 years of multimodality therapy, culminating in a >70% overall 5-year survival. Prognosis for RMS is dependent on primary tumor site, age, completeness of resection, presence and number of metastatic sites, histology, and biology of the tumor cells. Multimodality treatment is based on risk stratification according to pre-treatment stage, postoperative group, histology, and site. Unique to RMS is the concept of postoperative clinical grouping that assesses the completeness of disease resection and takes into account lymph node evaluation at both the regional and metastatic basins. At all sites, if complete operative resection of disease is accomplished, including microscopic disease, survival is improved. Therefore, the surgeon plays a vital role in determining risk stratification for treatment, local control of the primary tumor and overall outcome for the patient with RMS.
authors.affiliation: Division of Pediatric General and Thoracic Surgery, Cincinnati Children׳s Hospital Medical Center, Cincinnati, OH. Electronic address: Roshni.Dasgupta@cchmc.org.
authors.forename: Roshni
authors.initials: R
authors.lastname: Dasgupta
authors.affiliation: Universitätsklinik für Kinder- und Jugendmedizin, Lehrstuhl für Kinderchirurgie und Kinderurologie, Vizepräsident der Deutschen Gesellschaft für Chirurgie, Tübingen, Germany.
authors.forename: Jörg
authors.initials: J
authors.lastname: Fuchs
authors.affiliation: Department of Surgery, Brody School of Medicine, East Carolina University, Greenville, NC.
authors.forename: David
authors.initials: D
authors.lastname: Rodeberg
mesh_terms: D017024:Chemotherapy, Adjuvant; D002648:Child; D006801:Humans; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000628:therapy; D009367:Neoplasm Staging; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D012208:Rhabdomyosarcoma / Q000175:diagnosis / Q000473:pathology / Q000601:surgery* / Q000628:therapy; D018570:Risk Assessment; D016896:Treatment Outcome
keywords: Local control; Rhabdomyosarcoma; Surgical resection