title: RNA-binding proteins in immune regulation: a focus on CCCH zinc finger proteins.
abstract: Nearly 60 CCCH zinc finger proteins have been identified in humans and mice. These proteins are involved in the regulation of multiple steps of RNA metabolism, including mRNA splicing, polyadenylation, transportation, translation and decay. Several CCCH zinc finger proteins, such as tristetraprolin (TTP), roquin 1 and MCPIP1 (also known as regnase 1), are crucial for many aspects of immune regulation by targeting mRNAs for degradation and modulation of signalling pathways. In this Review, we focus on the emerging roles of CCCH zinc finger proteins in the regulation of immune responses through their effects on cytokine production, immune cell activation and immune homeostasis.
authors.affiliation: Department of Basic Medical Science and Shock/Trauma Research Center, School of Medicine, University of Missouri-Kansas City, 2411 Holmes Street, Kansas City, Missouri, Missouri 64108, USA.
authors.forename: Mingui
authors.initials: M
authors.lastname: Fu
authors.affiliation: Signal Transduction Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, North Carolina 27709, USA.
authors.forename: Perry J
authors.initials: PJ
authors.lastname: Blackshear
mesh_terms: D000818:Animals; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D051379:Mice; D016601:RNA-Binding Proteins / Q000276:immunology*; D016335:Zinc Fingers / Q000276:immunology*
chemical_list: D016601:RNA-Binding Proteins