title: [Aplasia cutis congenita associated with epidermolysis bullosa].
abstract: BACKGROUND
  Aplasia cutis congenita (ACC) is a skin condition of rare presentation, this disease is characterized by absence of skin at birth and associated with facial, skin and bone skull deformities. The diagnosis is mainly clinical.
  
  
  METHODS
  Male 5 days after birth, unique product of primigravida mother and no family history of relevance. Physical examination revealed bilateral and symmetrical skin defects of both lower extremities, the disease is characterized by skin fragility, scabs, and coated pseudomembrane ulcers, decreased interdigital space between toes of the left foot, retraction of the foot and genu varum. It was handled with allograft of epidermis cultured in vitro, general wound care and clinical follow-up.
  
  
  CONCLUSIONS
  ACC associated with epidermolysis bullosa is one of the rarer forms of presentation. It is necessary to rule out other skin diseases. Clinical management is recommended with biological or synthetic skin cover, infection prevention, early treatment of complications and clinical follow.
authors.affiliation: Unidad Médica de Alta Especialidad, Unidad de Quemados, Hospital de Especialidades No. 2, Instituto Mexicano del Seguro Social, Ciudad Obregón, Sonora, México. Electronic address: drfelix44@gmail.com.
authors.forename: Félix
authors.initials: F
authors.lastname: Muñoz-Guerrero
authors.affiliation: Servicio de Urgencias Médicas, Hospital General de Zona No. 30, Instituto Mexicano del Seguro Social, Mexicali, Baja California, México.
authors.forename: Adrián Antonio
authors.initials: AA
authors.lastname: Muñoz-Solís
authors.affiliation: Departamento de Ciencias de la Salud - Unidad Cajeme, Universidad de Sonora, Ciudad Obregón, Sonora, México.
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Ornelas-Aguirre
mesh_terms: D004476:Ectodermal Dysplasia / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D004817:Epidermis / Q000637:transplantation; D004820:Epidermolysis Bullosa / Q000150:complications*; D005500:Follow-Up Studies; D005532:Foot Deformities, Congenital; D056305:Genu Varum; D006801:Humans; D007231:Infant, Newborn; D036341:Intercellular Signaling Peptides and Proteins / Q000627:therapeutic use; D008297:Male; D009924:Organ Culture Techniques; D058106:Wound Closure Techniques; D014945:Wound Healing
chemical_list: D036341:Intercellular Signaling Peptides and Proteins
keywords: Aloinjerto de tejido compuesto; Aplasia cutis congenita; Aplasia cutis congénita; Composite tissue allograft; Infant; Infante