title: A comparative outcomes analysis evaluating clinical effectiveness in two different human placental membrane products for wound management.
abstract: Advances in tissue preservation have led to the commercialization of human placental membranes for the purposes of wound management with each product being characterized by different compositions and properties. The a priori specification of the research question in this investigator-initiated study focused on the clinical outcomes in two nonrandomized, however statistically equal and homogenous patient cohorts receiving either a viable intact cryopreserved human placental membrane (vCPM) or a dehydrated human amnion/chorion membrane (dHACM), for the management of wounds at a single center. A total of 79 patients with 101 wounds were analyzed: 40 patients with 46 wounds received vCPM and 39 patients with 55 wounds received dHACM. The proportion of wounds achieving complete wound closure was 63.0% (29/46) for vCPM and 18.2% (10/55) for dHACM (p < 0.0001) for all treated wounds combined. This is the first comparative effectiveness study to report on the clinical outcomes associated with the use of different placental wound care products once broadly implemented in the clinical setting.
authors.affiliation: Bozeman Health Deaconess Hospital, Wound and Hyperbaric Center, Bozeman, Montana, and.
authors.forename: Eric L
authors.initials: EL
authors.lastname: Johnson
authors.affiliation: Bozeman Health Deaconess Hospital, Wound and Hyperbaric Center, Bozeman, Montana, and.
authors.forename: James T
authors.initials: JT
authors.lastname: Marshall
authors.affiliation: Osiris Therapeutics, Inc., Columbia, Maryland.
authors.forename: Georgina M
authors.initials: GM
authors.lastname: Michael
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000650:Amnion; D002823:Chorion; D057186:Comparative Effectiveness Research; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010920:Placenta; D011247:Pregnancy; D016896:Treatment Outcome; D014945:Wound Healing / Q000502:physiology*; D014947:Wounds and Injuries / Q000503:physiopathology* / Q000628:therapy*