title: Protein-Modified CuS Nanotriangles: A Potential Multimodal Nanoplatform for In Vivo Tumor Photoacoustic/Magnetic Resonance Dual-Modal Imaging.
abstract: Controllable preparation of water-soluble multifunctional nanoprobes is of great significance for cancer early diagnosis. In this study, protein-modified hydrophilic copper sufide (CuS) nanotriangles with tunable absorption in the second near-infrared region are developed in the presence of halide ions. Further, gadolinium ions chelated diethylenetriaminepentaacetic acid is conjugated on it by using the unique characteristics of the protein-protected nanotriangles. Specifically, the as-obtained nanostructures are investigated as contrast agents for enhanced in vivo photoacoustic/magnetic resonance dual-modal tumor imaging. More importantly, in vitro and in vivo toxicity analysis are also performed, which show that the dual-modal nanoprobes are biocompatible for most of the cases. It is demonstrated that the novel as-prepared protein-modified nanotriangles are able to work as a nanoplatform to construct dual-modal nanoprobes, which paves a new avenue for improving the photoacoustic/magnetic resonance imaging contrast in cancer detection. It should be pointed out that other functional blocks may also be linked on it, which makes it a general method to design multifunctional nanoprobes.
authors.affiliation: Bioimaging Core, Faculty of Health Sciences, University of Macau, Macau SAR, 999078, P. R. China.
authors.forename: Duyang
authors.initials: D
authors.lastname: Gao
authors.affiliation: Paul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, P. R. China.
authors.forename: Zonghai
authors.initials: Z
authors.lastname: Sheng
authors.affiliation: Bioimaging Core, Faculty of Health Sciences, University of Macau, Macau SAR, 999078, P. R. China.
authors.forename: Yubin
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Paul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, P. R. China.
authors.forename: Dehong
authors.initials: D
authors.lastname: Hu
authors.affiliation: Bioimaging Core, Faculty of Health Sciences, University of Macau, Macau SAR, 999078, P. R. China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Bioimaging Core, Faculty of Health Sciences, University of Macau, Macau SAR, 999078, P. R. China.
authors.forename: Xuanjun
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Paul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, P. R. China.
authors.forename: Hairong
authors.initials: H
authors.lastname: Zheng
authors.affiliation: Bioimaging Core, Faculty of Health Sciences, University of Macau, Macau SAR, 999078, P. R. China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Yuan
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D003287:Contrast Media / Q000737:chemistry / Q000494:pharmacology; D003300:Copper / Q000737:chemistry / Q000494:pharmacology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D051379:Mice; D008807:Mice, Inbred BALB C; D053758:Nanoparticles / Q000737:chemistry*; D009374:Neoplasms, Experimental / Q000000981:diagnostic imaging*; D061088:Photoacoustic Techniques; D013440:Sulfides / Q000737:chemistry / Q000494:pharmacology
chemical_list: D003287:Contrast Media; D013440:Sulfides; D003300:Copper
keywords: CuS nanotriangles; dual-modal nanoprobes; magnetic resonance imaging; photoacoustic imaging; protein-modified