title: Anisotropic phantom to calibrate high-q diffusion MRI methods.
abstract: A silicon oil-filled glass capillary array is proposed as an anisotropic diffusion MRI phantom. Together with a computational/theoretical pipeline these provide a gold standard for calibrating and validating high-q diffusion MRI experiments. The phantom was used to test high angular resolution diffusion imaging (HARDI) and double pulsed-field gradient (d-PFG) MRI acquisition schemes. MRI-based predictions of microcapillary diameter using both acquisition schemes were compared with results from optical microscopy. This phantom design can be used for quality control and quality assurance purposes and for testing and validating proposed microstructure imaging experiments and the processing pipelines used to analyze them.
authors.affiliation: Section on Quantitative Imaging and Tissue Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA; Center for Neuroscience and Regenerative Medicine, The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc, Bethesda, MD, USA. Electronic address: komloshm@mail.nih.gov.
authors.forename: M E
authors.initials: ME
authors.lastname: Komlosh
authors.affiliation: Section on Quantitative Imaging and Tissue Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
authors.forename: D
authors.initials: D
authors.lastname: Benjamini
authors.affiliation: Section on Quantitative Imaging and Tissue Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
authors.forename: A S
authors.initials: AS
authors.lastname: Barnett
authors.affiliation: Microscopy and Imaging Core, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
authors.forename: V
authors.initials: V
authors.lastname: Schram
authors.affiliation: Section on Quantitative Imaging and Tissue Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
authors.forename: F
authors.initials: F
authors.lastname: Horkay
authors.affiliation: Section on Quantitative Imaging and Tissue Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
authors.forename: A V
authors.initials: AV
authors.lastname: Avram
authors.affiliation: Section on Quantitative Imaging and Tissue Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
authors.forename: P J
authors.initials: PJ
authors.lastname: Basser
mesh_terms: D000465:Algorithms; D016880:Anisotropy; D002138:Calibration; D002196:Capillaries / Q000033:anatomy & histology; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D004574:Electromagnetic Fields; D007091:Image Processing, Computer-Assisted; D019047:Phantoms, Imaging; D016062:Porosity; D015203:Reproducibility of Results
keywords: Anisotropic diffusion; DDE; Diffusion; MRI; Microstructure; Phantom; d-PFG