title: Assessment of Synthetic Glue for Mesh Attachment in Laparoscopic Sacrocolpopexy: A Prospective Multicenter Pilot Study.
abstract: To assess the anatomic efficacy and safety of synthetic glue to fix prosthetic material in laparoscopic sacrocolpopexy.
  
  
  
  A 1-year follow-up in a prospective multicenter pilot study between November 2013 and November 2014 (Canadian Task Force Classification II-2).
  
  
  
  An academic urogynecology research hospital.
  
  
  
  Seventy consecutive patients with Pelvic Organ Prolapse Quantification stage ≥3 anterior and/or medial prolapse underwent laparoscopic sacrocolpopexy.
  
  
  
  All women underwent laparoscopic sacrocolpopexy with the same standardized technique using a synthetic surgical glue to fix anterior and posterior meshes.
  
  
  
  Patients were followed up at 1 month and 1 year, with anatomic and functional assessment (Pelvic Floor Distress Inventory-20, Pelvic Floor Impact Questionnaire-7, and Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire-12). Anatomic success was defined as 1-year Pelvic Organ Prolapse Quantification stage ≤1. Sixty-six patients were included; the mean age was 56.7 ± 1.2 years. The mean operative time was 145 ± 5 minutes. The mean glue fixation time was less than 2 minutes for both anterior and posterior meshes. The 1-year anatomic success rate was 87.5% in the anterior compartment (Ba at -2.3 cm, p < .0001) and 95.3% in the medial compartment (point C at -6.1 cm, p < .0001). There were no intra- or postoperative complications and no cases of mesh exposure; 5 cases of mesh shrinkage (7.8%) were observed at 1 year. The postoperative urinary stress incontinence rate was 29.7% at 1 year. Eight patients (12.1%) underwent revision surgery with transobturator tape. All quality of life scores showed significant improvement (p < .0001) at 1 year.
  
  
  
  Synthetic glue attachment of prosthetic material in laparoscopic sacrocolpopexy proved straightforward, safe, time-saving, and effective at 1 year. Prospective randomized studies will be needed to confirm the long-term benefit.
authors.affiliation: Hôpital Femme Mère Enfant, Service de Chirurgie Urogynécologique, Lyon-Bron, France. Electronic address: gery.lamblin@chu-lyon.fr.
authors.forename: Gery
authors.initials: G
authors.lastname: Lamblin
authors.affiliation: Hôpital de la Croix Rousse, Service de Chirurgie Gynécologique, Lyon, France.
authors.forename: Gil
authors.initials: G
authors.lastname: Dubernard
authors.affiliation: Hôpital de la Croix Rousse, Service de Chirurgie Gynécologique, Lyon, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: de Saint Hilaire
authors.affiliation: Centre Hospitalier Lyon Sud, Service de Chirurgie Gynécologique, Pierre Bénite, France.
authors.forename: Franck
authors.initials: F
authors.lastname: Jacquot
authors.affiliation: Hôpital Femme Mère Enfant, Service de Chirurgie Urogynécologique, Lyon-Bron, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Chabert
authors.affiliation: Hôpital Femme Mère Enfant, Service de Chirurgie Urogynécologique, Lyon-Bron, France.
authors.forename: Gautier
authors.initials: G
authors.lastname: Chene
authors.affiliation: Centre Hospitalier Lyon Sud, Service de Chirurgie Gynécologique, Pierre Bénite, France.
authors.forename: François
authors.initials: F
authors.lastname: Golfier
mesh_terms: D005260:Female; D006801:Humans; D010535:Laparoscopy; D008875:Middle Aged; D056887:Pelvic Organ Prolapse / Q000601:surgery*; D010865:Pilot Projects; D011446:Prospective Studies; D011788:Quality of Life; D013526:Surgical Mesh; D014014:Tissue Adhesives
chemical_list: D014014:Tissue Adhesives
keywords: Cyanoacrylate; Laparoscopic sacrocolpopexy; Pelvic organ prolapse; Vaginal prosthetic glue