title: A Purinergic Trail for Metastases.
abstract: Nucleotides and nucleosides have emerged as important modulators of tumor biology. Recently acquired evidence shows that, when these molecules are released by cancer cells or surrounding tissues, they act as potent prometastatic factors, favoring tumor cell migration and tissue colonization. Therefore, nucleotides and nucleosides should be considered as a new class of prometastatic factors. In this review, we focus on the prometastatic roles of nucleotides and discuss future applications of purinergic signaling modulation in view of antimetastatic therapies.
authors.affiliation: Department of Life Science and Biotechnology, University of Ferrara, Ferrara, Italy. Electronic address: davide.ferrari@unife.it.
authors.forename: Davide
authors.initials: D
authors.lastname: Ferrari
authors.affiliation: Laboratory of Immunogenetics and CeRMS, Department of Medical Sciences, University of Torino and Transplant Immunology, Città della Salute e della Scienza, Torino, Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Malavasi
authors.affiliation: Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Antonioli
mesh_terms: D000818:Animals; D006801:Humans; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology*; D011684:Purine Nucleosides / Q000378:metabolism*; D011685:Purine Nucleotides / Q000378:metabolism*; D018047:Receptors, Purinergic P1 / Q000378:metabolism; D018048:Receptors, Purinergic P2 / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D011684:Purine Nucleosides; D011685:Purine Nucleotides; D018047:Receptors, Purinergic P1; D018048:Receptors, Purinergic P2
keywords: P1 receptors; P2 receptors; chemotaxis; extracellular nucleotides; tumor