title: Clindamycin-induced acute generalised exanthematous pustulosis: five cases and a review of the literature.
abstract: Acute generalised exanthematous pustulosis (AGEP) is a rare but serious cutaneous adverse drug reaction, often related to antibiotics such as beta-lactams or macrolides. However, it is rarely associated with clindamycin which belongs to the lincosamide antibiotics. The Netherlands Pharmacovigilance Centre Lareb received five reports of AGEP associated with the use of clindamycin. We present these five cases and provide support for this association from the Lareb database, the database of the WHO Collaborating Centre for International Drug Monitoring (Vigibase™), the database of the European Medicine Agency (Eudravigilance), and from a mini review of the literature.
authors.affiliation: 1Netherlands Pharmacovigilance Centre Lareb, 's-Hertogenbosch, the Netherlands.
authors.forename: T J L
authors.initials: TJ
authors.lastname: Smeets
authors.forename: N
authors.initials: N
authors.lastname: Jessurun
authors.forename: L
authors.initials: L
authors.lastname: Härmark
authors.forename: S H
authors.initials: SH
authors.lastname: Kardaun
mesh_terms: D000038:Abscess / Q000188:drug therapy; D056150:Acute Generalized Exanthematous Pustulosis / Q000209:etiology*; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D002981:Clindamycin / Q000009:adverse effects*; D003875:Drug Eruptions; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010304:Paronychia / Q000188:drug therapy; D018805:Sepsis / Q000188:drug therapy; D012852:Sinusitis / Q000188:drug therapy; D014069:Tonsillitis / Q000188:drug therapy
chemical_list: D000900:Anti-Bacterial Agents; D002981:Clindamycin