title: Modification and intercalation of layered zirconium phosphates: a solid-state NMR monitoring.
abstract: Several layered zirconium phosphates treated with Zr(IV) ions, modified by monomethoxy-polyethyleneglycol-monophosphate and intercalated with doxorubicin hydrochloride have been studied by solid-state MAS NMR techniques. The organic components of the phosphates have been characterized by the13C{1H} CP MAS NMR spectra compared with those of initial compounds. The multinuclear NMR monitoring has provided to establish structure and covalent attachment of organic/inorganic moieties to the surface and interlayer spaces of the phosphates. The MAS NMR experiments including kinetics of proton-phosphorus cross polarization have resulted in an unusual structure of zirconium phosphate 6 combining decoration of the phosphate surface by polymer units and their partial intercalation into the interlayer space. Copyright © 2016 John Wiley & Sons, Ltd.
authors.affiliation: Laboratory for Nuclear Magnetic Resonance, Department of Chemistry, Texas A&M University, College Station, TX, USA.
authors.forename: Vladimir I
authors.initials: VI
authors.lastname: Bakhmutov
authors.affiliation: Laboratory for Nuclear Magnetic Resonance, Department of Chemistry, Texas A&M University, College Station, TX, USA.
authors.forename: Yuwei
authors.initials: Y
authors.lastname: Kan
authors.affiliation: Laboratory for Nuclear Magnetic Resonance, Department of Chemistry, Texas A&M University, College Station, TX, USA.
authors.forename: Javeed Ahmad
authors.initials: JA
authors.lastname: Sheikh
authors.affiliation: Department of Chemistry, University of Puerto Rico-Río Piedras Campus, University of Puerto Rico, Río Piedras, Puerto Rico.
authors.forename: Julissa
authors.initials: J
authors.lastname: González-Villegas
authors.affiliation: Department of Chemistry, University of Puerto Rico-Río Piedras Campus, University of Puerto Rico, Río Piedras, Puerto Rico.
authors.forename: Jorge L
authors.initials: JL
authors.lastname: Colón
authors.affiliation: Laboratory for Nuclear Magnetic Resonance, Department of Chemistry, Texas A&M University, College Station, TX, USA.
authors.forename: Abraham
authors.initials: A
authors.lastname: Clearfield
mesh_terms: D004317:Doxorubicin / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D011092:Polyethylene Glycols / Q000737:chemistry; D013499:Surface Properties; D015040:Zirconium / Q000737:chemistry*
chemical_list: C027006:zirconium phosphate; D011092:Polyethylene Glycols; D004317:Doxorubicin; D015040:Zirconium
keywords: cross polarization; intercalation; solid-state NMR; zirconium phosphates