title: Doped graphene/Cu nanocomposite: A high sensitivity non-enzymatic glucose sensor for food.
abstract: An amperometric non-enzymatic glucose sensor was developed based on nitrogen-doped graphene with dispersed copper nanoparticles (Cu-NGr). The sensing element was tested in conjunction with a modified glassy carbon electrode for glucose detection. The Cu-NGr composite was prepared by one pot synthesis from a mixture of graphene oxide, copper nitrate and uric acid, followed by thermal annealing at 900°C for 1h. Detailed characterizations showed homogeneous copper nanoparticle dispersion and the presence of significant proportion of graphitic nitrogen. The developed electrode presented high electrocatalytic activity towards glucose through synergetic effect of copper nanoparticles and nitrogen-doped graphene. Amperometric analysis confirmed high glucose sensitivity and ultra-low detection of 10nM glucose over a linear range. The sensor was tested for direct application to detect glucose in food samples for which the sensor displayed high selectivity with excellent reproducibility and recovery in complex food materials.
authors.affiliation: Integrated Polymer and Systems Engineering Laboratory, School of Chemical & Biomolecular Engineering, The University of Sydney, NSW 2006, Australia.
authors.forename: Luba
authors.initials: L
authors.lastname: Shabnam
authors.affiliation: Laboratory of Sustainable Technology, School of Chemical & Biomolecular Engineering, University of Sydney, NSW 2006, Australia.
authors.forename: Shaikh Nayeem
authors.initials: SN
authors.lastname: Faisal
authors.affiliation: Laboratory of Sustainable Technology, School of Chemical & Biomolecular Engineering, University of Sydney, NSW 2006, Australia.
authors.forename: Anup Kumar
authors.initials: AK
authors.lastname: Roy
authors.affiliation: Integrated Polymer and Systems Engineering Laboratory, School of Chemical & Biomolecular Engineering, The University of Sydney, NSW 2006, Australia.
authors.forename: Enamul
authors.initials: E
authors.lastname: Haque
authors.affiliation: Laboratory of Sustainable Technology, School of Chemical & Biomolecular Engineering, University of Sydney, NSW 2006, Australia.
authors.forename: Andrew I
authors.initials: AI
authors.lastname: Minett
authors.affiliation: Integrated Polymer and Systems Engineering Laboratory, School of Chemical & Biomolecular Engineering, The University of Sydney, NSW 2006, Australia. Electronic address: vincent.gomes@sydney.edu.au.
authors.forename: Vincent G
authors.initials: VG
authors.lastname: Gomes
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D003300:Copper / Q000737:chemistry*; D055664:Electrochemical Techniques; D005504:Food Analysis / Q000379:methods*; D005947:Glucose / Q000032:analysis*; D006108:Graphite / Q000737:chemistry*; D053761:Nanocomposites / Q000737:chemistry*
chemical_list: D006108:Graphite; D003300:Copper; D005947:Glucose
keywords: Copper nanoparticles; Glucose detection; Nitrogen-doped graphene; Non-enzymatic