title: Oxidant Status following Cardiac Surgery with Phosphorylcholine-Coated Extracorporeal Circulation Systems.
abstract: Introduction. Extracorporeal circulation (ECC) related systemic oxidative stress is a well-known entity but the underlying mechanisms are not clearly described. Our aim was to investigate the relation between the oxidative stress indices, inflammatory markers, and phosphorylcholine-coated (PCC) ECC systems.Patients and Methods. Thirty-two consecutive coronary artery bypass grafting (CABG) cases were randomly assigned to Group I (PCC,n= 18) and Group II (noncoated,n= 14) ECC circuits. Total Antioxidant Status (TAS), Total Oxidant Status (TOS), Tumor Necrosis Factor-α(TNF-α), Interleukin-1β(IL-β), Interleukin-6 (IL-6), Interleukin-8 (IL-8), Interleukin-10 (IL-10), and Procalcitonin (PCT) levels were measured at 5 different time points. The association between the oxidative indices levels and PCC system used was analyzed.Results. In Group I TOS and TAS statuses were increased atT1,T2,T3, andT4, while IL-10 and TNF-αlevels accompanied those raises only atT2 (Group I-Group II, 4.73 ± 2.04 versus 2.79 ± 0.63,p= 0.002, and 30.56 ± 8.11 versus 23.97 ± 7.8,p= 0.031, resp.). In contrast, mean TAS and TOS levels were similar to baseline at all time points in Group II but IL-6 and IL-8 levels were increased atT2 (Group I-Group II, 16.84 ± 5.63 versus 44.81 ± 17.0,p= 0.001, and 38.88 ± 9.8 versus 46.14 ± 9.25,p= 0.038, resp.).Conclusion. Even coated ECC systems are still incapable of attenuating the inflammatory response to cardiopulmonary bypass (CPB).
authors.affiliation: Department of Cardiovascular Surgery, Institute of Cardiology, Istanbul University, Istanbul, Turkey.
authors.forename: Ali Can
authors.identifier: 0000-0002-6202-3262
authors.initials: AC
authors.lastname: Hatemi
authors.affiliation: Department of Cardiovascular Surgery, Faculty of Medicine, Süleyman Demirel University, Isparta, Turkey.
authors.forename: Kadir
authors.identifier: 0000-0002-6860-7058
authors.initials: K
authors.lastname: Çeviker
authors.affiliation: Pediatric Cardiac Surgery Clinic, Kartal Kosuyolu YİEAH, Istanbul, Turkey.
authors.forename: Aybala
authors.identifier: 0000-0002-1968-1868
authors.initials: A
authors.lastname: Tongut
authors.affiliation: Department of Cardiovascular Surgery, Faculty of Medicine, Süleyman Demirel University, Isparta, Turkey.
authors.forename: İlhan
authors.identifier: 0000-0002-4197-3381
authors.initials: İ
authors.lastname: Özgöl
authors.affiliation: Department of Cardiovascular Surgery, Institute of Cardiology, Istanbul University, Istanbul, Turkey.
authors.forename: Murat
authors.identifier: 0000-0002-0097-0395
authors.initials: M
authors.lastname: Mert
authors.affiliation: Division of Biochemistry, Institute of Cardiology, Istanbul University, Istanbul, Turkey.
authors.forename: Ayşem
authors.initials: A
authors.lastname: Kaya
mesh_terms: D001026:Coronary Artery Bypass; D003710:Demography; D005112:Extracorporeal Circulation; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood; D007378:Interleukins / Q000097:blood; D008297:Male; D008875:Middle Aged; D016877:Oxidants / Q000097:blood*; D018384:Oxidative Stress; D010767:Phosphorylcholine / Q000494:pharmacology*
chemical_list: D007378:Interleukins; D016877:Oxidants; D010767:Phosphorylcholine