title: Biocompatible testing and physical properties of curdlan-grafted poly(vinyl alcohol) scaffold for bone tissue engineering.
abstract: Curdlan was grafted to poly(vinyl alcohol) (PVA) to form a porous scaffold. The grafted PVA-curdlan 3D scaffold was then examined by Fourier transform infrared spectroscopy (FT-IR). Grafting increased the water absorbency of the scaffold by 280%. Scanning electron microscopic (SEM) observations of the material revealed that the 3D scaffold was highly porous when it was fabricated using a homogenizer at 300rpm. Compression testing revealed that, increasing the amount of curdlan increased the strength of the 3D scaffold to 8-16×10-3MPa. Over 28days, various enzymes degraded the 3D scaffold, causing a weight loss of up to 20-40%. In vivo tests revealed favorable cell proliferation and growth in a 3D scaffold.
authors.affiliation: Department of Biological Science and Technology, I-Shou University, Kaohsiung 82445, Taiwan, ROC. Electronic address: wenchuan@isu.edu.tw.
authors.forename: Wen-Chuan
authors.initials: WC
authors.lastname: Hsieh
authors.affiliation: Department of Biological Science and Technology, I-Shou University, Kaohsiung 82445, Taiwan, ROC.
authors.forename: Chia-Chi
authors.initials: CC
authors.lastname: Hsu
authors.affiliation: Department of Medical Research, E-Da Hospital, Kaohsiung, Taiwan, ROC; Cell Therapy and Research Center, Department of Medical Research, E-Da Cancer Hospital, Kaohsiung, Taiwan, ROC.
authors.forename: Li-Yen
authors.initials: LY
authors.lastname: Shiu
authors.affiliation: Department of Biological Science and Technology, I-Shou University, Kaohsiung 82445, Taiwan, ROC.
authors.forename: Yu-Jing
authors.initials: YJ
authors.lastname: Zeng
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D008422:Materials Testing; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D016062:Porosity; D017550:Spectroscopy, Fourier Transform Infrared; D023822:Tissue Engineering; D054457:Tissue Scaffolds / Q000737:chemistry*; D047071:beta-Glucans / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D047071:beta-Glucans; C038459:curdlan; D011142:Polyvinyl Alcohol
keywords: Biodegradable polymer; Curdlan; In vivo cultivation; Scaffold