title: Soluble HLA-G concentrations in obese women during pregnancy and in cord blood.
abstract: Little is known about soluble HLA-G (sHLA-G) concentrations in obese pregnant women with uncomplicated pregnancies.
  
  
  
  To investigate the role of sHLA-G in obese pregnancies.
  
  
  
  Case-control study, from 2013 to 2015.
  
  
  
  A tertiary care centre.
  
  
  
  168 healthy normal weight women and 59 overweight/obese women; to avoid the effect of preeclampsia on sHLA-G concentrations, cases were further divided in two groups: 42 with normotensive pregnancy and 17 who developed preeclampsia.
  
  
  
  all the women enrolled received standard antenatal care and plasma sample collections were performed.
  
  
  
  sHLA-G concentrations during pregnancy, before delivery and in cord blood.
  
  
  
  Maternal sHLA-G concentrations in overweight/obese with normotensive pregnancies increased by 14.7% (IQR=-26.4 to +89.6) in the 2nd trimester and by 19.6% (IQR=-33 to +104) before delivery and were significantly higher than in controls (p=0.024). Median cord blood sHLA-G concentrations were 53.5ng/ml (IQR=36-62.7) in the overweight/obese women with uncomplicated pregnancies (p<0.001 compared to controls) and 19.7ng/ml (IQR=7.5-36.3) in controls. Maternal concentrations of sHLA-G in the two trimesters and before delivery were significantly lower among subjects who developed preeclampsia than in controls (p<0.001) or in obese subjects with normotensive pregnancies (p<0.001).
  
  
  
  sHLA-G concentratons are higher in normotensive overweight/obese women and their babies while lower in preeclamptic overweight/obese women and their cords. Obesity influences maternal and fetal sHLA-G concentrations during pregnancy, to optimize the reproductive success, while preeclampsia impairs the mother-offspring antinflammatory response.
authors.affiliation: Department of Obstetrics and Gynecology, IRCCS Foundation Policlinico San Matteo and University of Pavia, 27100 Pavia, Italy.
authors.forename: Fausta
authors.initials: F
authors.lastname: Beneventi
authors.affiliation: Department of Obstetrics and Gynecology, IRCCS Foundation Policlinico San Matteo and University of Pavia, 27100 Pavia, Italy. Electronic address: elena.loc@libero.it.
authors.forename: Elena
authors.initials: E
authors.lastname: Locatelli
authors.affiliation: Department of Pediatrics, University of Pavia, IRCCS Foundation Policlinico San Matteo and University of Pavia, 27100 Pavia, Italy.
authors.forename: Mara
authors.initials: M
authors.lastname: De Amici
authors.affiliation: Immunogenetics Laboratory, Immunohematology and Transfusion Center, IRCCS Foundation Policlinico San Matteo and University of Pavia, 27100 Pavia, Italy.
authors.forename: Miryam
authors.initials: M
authors.lastname: Martinetti
authors.affiliation: Department of Obstetrics and Gynecology, IRCCS Foundation Policlinico San Matteo and University of Pavia, 27100 Pavia, Italy.
authors.forename: Arsenio
authors.initials: A
authors.lastname: Spinillo
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D005865:Gestational Age; D059951:HLA-G Antigens / Q000097:blood* / Q000235:genetics; D006801:Humans; D007112:Immunity, Maternally-Acquired; D007231:Infant, Newborn; D008297:Male; D009765:Obesity / Q000150:complications / Q000276:immunology*; D021041:Placental Circulation; D011110:Polymorphism, Genetic; D011225:Pre-Eclampsia / Q000276:immunology*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D017384:Sequence Deletion / Q000235:genetics
chemical_list: D059951:HLA-G Antigens
keywords: Obesity; Pregnancy; Soluble HLA-G