title: Interleukin-16 rs11556218 is associated with a risk of osteoporosis in Chinese postmenopausal women.
abstract: BACKGROUND
  Interleukins (ILs), a multifunctional cytokine, play a fundamental role in inflammatory diseases, as well as in the development of osteoporosis. However, there are no data about the role of IL-16 polymorphism in development of osteoporosis.
  
  
  METHODS
  In this study, we investigated the association between the IL-16 rs11556218 T/G and rs4072122 C/T polymorphisms respectively, and the risk of osteoporosis among 230 patients with osteoporosis and 230 healthy controls. Serum IL-16 level and its correlation with the IL-16 rs11556218 T/G genotypes were analyzed.
  
  
  RESULTS
  Significant differences of genotype distribution were observed between osteoporosis cases and controls at the IL-16 rs11556218 T/G genotypes. Compared with the IL-16 rs11556218 T/G homozygote TT, the heterozygous TG genotype was associated with significantly increased risk for osteoporosis (OR=2.29, 95% CI=(1.15-3.82), p=0.026); the GG genotype was associated with increased risk for osteoporosis (OR=1.84, 95% CI=1.48-3.97, p=0.015). TG and GG combined variants that were associated with increased risk for osteoporosis compared with the TT genotype (OR=1.92, 95% CI=1.43-4.86, p=0.023). Moreover, in patients with osteoporosis, there was a correlation between the serum IL-16 and rs11556218 T/G genotype. However, the genotype and allele frequencies of IL-16 rs4072122 C/T polymorphisms in osteoporosis patients were not significantly different from controls.
  
  
  CONCLUSIONS
  IL-16 rs11556218 T/G genotype was associated with increased risk for development of osteoporosis in Chinese postmenopausal women.
authors.affiliation: Department of Endocrinology, Jining No.1 People's Hospital, No. 6 Health Road, Rencheng District, Jining 272011, China.
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Ma
authors.affiliation: Department of Endocrinology, Xinjiang Uiger Municipal People's Hospital, No. 91 Tianchi Road, Urumqi City, Xinjiang Uygur Autonomous Region, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Endocrinology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, China.
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Pharmacy Department, Zoucheng People's Hospital, Jining, Shandong 272000, China.
authors.forename: He
authors.initials: H
authors.lastname: Tian
authors.affiliation: Internal Medicine Department, Traditional Chinese Medicine Hospital of Jining, Jining, Shandong 272000, China.
authors.forename: Jianming
authors.initials: J
authors.lastname: Wang
authors.affiliation: Cardiovascular Department, Traditional Chinese Medicine Hospital of Jining, Jining, Shandong 272000, China.
authors.forename: Sanyun
authors.initials: S
authors.lastname: Liu
authors.affiliation: Pharmacy Department, Traditional Chinese Medicine Hospital of Sishui County, Jining, Shandong 272000, China.
authors.forename: Baoliang
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Spinal Surgery, Jining No.1 People's Hospital, No. 6 Health Road, Rencheng District, Jining 272011, China. Electronic address: monkey2335@sina.com.
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D019410:Interleukin-16 / Q000097:blood / Q000235:genetics*; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D019410:Interleukin-16
keywords: IL-16; Osteoporosis; Single-nucleotide polymorphism; Susceptibility