title: Single-Nucleotide Polymorphisms and Cancer Risk, Tumor Recurrence, or Survival of Head and Neck Cancer Patients.
abstract: OBJECTIVE
  This paper aims at studying the influence of single-nucleotide polymorphisms (SNPs) on cancer risk, tumor recurrence, and survival in head and neck (H&amp;N) cancer patients.
  
  
  METHODS
  A total of 45 SNPs in 41 genes were investigated. A total of 174 Caucasian H&amp;N cancer patients and 245 healthy blood donors were enrolled in the study.
  
  
  RESULTS
  Ten SNPs were associated with H&amp;N cancer risk, but the identified SNPs differed among males and females. Some of the SNPs were related to immune response genes. The immune response gene SNPs were also related to survival. In particular, we noted that the tumor necrosis factor alpha (TNFα) rs1800629 could have an influence on cancer risk, tumor recurrence as well as survival.
  
  
  CONCLUSIONS
  Genetic variation of the TNFα rs1800629 might be useful as a biomarker in clinical decision-making since it was found to be related to cancer risk, tumor recurrence, and survival of H&amp;N cancer patients.
authors.affiliation: Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
authors.forename: Nongnit
authors.initials: N
authors.lastname: Laytragoon-Lewin
authors.forename: Lena
authors.initials: L
authors.lastname: Cederblad
authors.forename: Bengt-Åke
authors.initials: BÅ
authors.lastname: Andersson
authors.forename: Mattias
authors.initials: M
authors.lastname: Olin
authors.forename: Mats
authors.initials: M
authors.lastname: Nilsson
authors.forename: Lars Erik
authors.initials: LE
authors.lastname: Rutqvist
authors.forename: Jan
authors.initials: J
authors.lastname: Lundgren
authors.forename: Mats
authors.initials: M
authors.lastname: Engström
authors.forename: Wieslaw
authors.initials: W
authors.lastname: Tytor
authors.forename: Sture
authors.initials: S
authors.lastname: Löfgren
authors.forename: Freddi
authors.initials: F
authors.lastname: Lewin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D004273:DNA, Neoplasm / Q000097:blood / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006258:Head and Neck Neoplasms / Q000097:blood / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000097:blood / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D012737:Sex Factors; D055815:Young Adult
chemical_list: D004273:DNA, Neoplasm