title: Bioanalysis of antitubercular drugs using liquid chromatography.
abstract: Tuberculosis is a life threatening disease and second to HIV in terms of deaths due to infectious diseases. Drug resistance development of the first-line drugs is a major concern in the treatment of this disease. There is no comprehensive and critical review in the literature of the bioanalytical methods for the determination of anti-tubercular agents from last two decades. This work offers a detailed account on the liquid chromatographic methods reported in the literature for the estimation of various anti-tubercular drugs. Major emphasis is given to sample preparation process, sensitivity of method, chromatographic separation conditions and detection systems used in their bioanalysis.
authors.affiliation: Academy of Scientific and Innovative Research, New Delhi, India; Pharmacokinetics and Metabolism Division, CSIR-Central Drug Research Institute, Lucknow, India.
authors.forename: Kanumuri Siva Rama
authors.initials: KSR
authors.lastname: Raju
authors.affiliation: Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Raebareli, India.
authors.forename: Manoj
authors.initials: M
authors.lastname: Gundeti
authors.affiliation: Pharmacokinetics and Metabolism Division, CSIR-Central Drug Research Institute, Lucknow, India.
authors.forename: Mohd Yaseen
authors.initials: MY
authors.lastname: Malik
authors.affiliation: Pharmacokinetics and Metabolism Division, CSIR-Central Drug Research Institute, Lucknow, India.
authors.forename: Naveen
authors.initials: N
authors.lastname: Kadian
authors.affiliation: Pharmacokinetics and Metabolism Division, CSIR-Central Drug Research Institute, Lucknow, India.
authors.forename: Mamunur
authors.initials: M
authors.lastname: Rashid
authors.affiliation: Academy of Scientific and Innovative Research, New Delhi, India; Pharmacokinetics and Metabolism Division, CSIR-Central Drug Research Institute, Lucknow, India.
authors.forename: Isha
authors.initials: I
authors.lastname: Taneja
authors.affiliation: Analytical Chemistry Lab, CSIR-Indian Institute of Toxicology Research, Lucknow, India.
authors.forename: Sheelendra Pratap
authors.initials: SP
authors.lastname: Singh
authors.affiliation: Academy of Scientific and Innovative Research, New Delhi, India; Pharmacokinetics and Metabolism Division, CSIR-Central Drug Research Institute, Lucknow, India; Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Raebareli, India. Electronic address: wahajuddin@cdri.res.in.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Wahajuddin
mesh_terms: D000818:Animals; D000995:Antitubercular Agents / Q000032:analysis*; D002853:Chromatography, Liquid / Q000379:methods / Q000706:statistics & numerical data; D006801:Humans; D053719:Tandem Mass Spectrometry / Q000379:methods* / Q000706:statistics & numerical data*
chemical_list: D000995:Antitubercular Agents
keywords: Antitubercular drugs; Bioanalysis; Liquid chromatography; Sample preparation; Therapeutic drug monitoring