title: Molecular and Cellular Characterization of Human CD8 T Suppressor Cells.
abstract: Bidirectional interactions between dendritic cells and Ag-experienced T cells initiate either a tolerogenic or immunogenic pathway. The outcome of these interactions is of crucial importance in malignancy, transplantation, and autoimmune diseases. Blockade of costimulation results in the induction of T helper cell anergy and subsequent differentiation of antigen-specific CD8+T suppressor/regulatory cells (Ts). Ts, primed in the presence of inhibitory signals, exert their inhibitory function in an antigen-specific manner, a feature with tremendous clinical potential. In transplantation or autoimmunity, antigen-specific Ts can enforce tolerance to auto- or allo-antigens, while otherwise leaving the immune response to pathogens uninhibited. Alternatively, blockade of inhibitory receptors results in the generation of cytolytic CD8+T cells, which is vital toward defense against tumors and viral diseases. Because CD8+T cells are MHC Class I restricted, they are able to recognize HLA-bound antigenic peptides presented not only by APC but also on parenchymal cells, thus eliciting or suppressing auto- or allo-immune reactions.
authors.affiliation: Immunogenetics and Cellular Immunology, Department of Pathology and Cell Biology, Columbia University , New York, NY , USA.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Xu
authors.affiliation: Immunogenetics and Cellular Immunology, Department of Pathology and Cell Biology, Columbia University , New York, NY , USA.
authors.forename: Sophey
authors.initials: S
authors.lastname: Ho
authors.affiliation: Immunogenetics and Cellular Immunology, Department of Pathology and Cell Biology, Columbia University , New York, NY , USA.
authors.forename: Chih-Chao
authors.initials: CC
authors.lastname: Chang
authors.affiliation: Immunogenetics and Cellular Immunology, Department of Pathology and Cell Biology, Columbia University , New York, NY , USA.
authors.forename: Qing-Yin
authors.initials: QY
authors.lastname: Zhang
authors.affiliation: Immunogenetics and Cellular Immunology, Department of Pathology and Cell Biology, Columbia University , New York, NY , USA.
authors.forename: Elena-Rodica
authors.initials: ER
authors.lastname: Vasilescu
authors.affiliation: Immunogenetics and Cellular Immunology, Department of Pathology and Cell Biology, Columbia University , New York, NY , USA.
authors.forename: George
authors.initials: G
authors.lastname: Vlad
authors.affiliation: Immunogenetics and Cellular Immunology, Department of Pathology and Cell Biology, Columbia University , New York, NY , USA.
authors.forename: Nicole
authors.initials: N
authors.lastname: Suciu-Foca
keywords: CD8+ T suppressor cells; ILT3; autoimmune disease; co-stimulation blockade; gene profile of CD8+ Ts; transplantation