title: Evaluation of Wound Healing Properties of Grape Seed, Sesame, and Fenugreek Oils.
abstract: Background. Medicinal plants have proved at all times to be a powerful remedy for health care. Accordingly, grape seed, sesame, and fenugreek extracted oils with pharmacological properties are investigated as wound treatments. This study assesses the potential of our oils for healing wounds induced on rats.Methods. Phytochemical analyses of oils have involved: quality value, polyphenol, chlorophylls, carotene, and fatty acids. Antibacterial activity was carried out. Antioxidant activity was evaluated: the scavenging effect on DPPH radicals, the reducing power, andβ-carotene discoloration. Uniform wound excision was induced on rats dorsum randomly divided into five groups: groups treated with "CICAFLORA®" and tested oils and untreated one. The posthealing biopsies were histologically assessed.Results. Wound biopsies treated with oils showed the best tissue regeneration compared to control groups. Groups treated with our oils and "CICAFLORA" had higher wound contraction percentage. Polyunsaturated fatty acids in oils act as inflammatory mediators increasing neovascularization, extracellular remodeling, migration, and cell differentiation. Wound healing effect was attributed to antibacterial and antioxidant synergy.Conclusion. According to findings, oils showed better activity in wound healing compared to "CICAFLORA" due to a phytoconstituents synergy. However, clinical trials on humans are necessary to confirm efficacy on human pathology.
authors.affiliation: Laboratory of Pharmacology, Faculty of Medicine of Sfax, University of Sfax, Sfax, Tunisia.
authors.forename: Dorsaf
authors.identifier: 0000-0002-0471-4014
authors.initials: D
authors.lastname: Moalla Rekik
authors.affiliation: Laboratories of Histology and Embryology, Faculty of Medicine of Sfax, University of Sfax, Sfax, Tunisia.
authors.forename: Sameh
authors.identifier: 0000-0003-1612-1811
authors.initials: S
authors.lastname: Ben Khedir
authors.affiliation: Laboratory of Pharmacology, Faculty of Medicine of Sfax, University of Sfax, Sfax, Tunisia.
authors.forename: Kamilia
authors.initials: K
authors.lastname: Ksouda Moalla
authors.affiliation: Olivier Institute, BP 1087, 3000 Sfax, Tunisia.
authors.forename: Naziha Grati
authors.initials: NG
authors.lastname: Kammoun
authors.affiliation: Laboratories of Histology and Embryology, Faculty of Medicine of Sfax, University of Sfax, Sfax, Tunisia.
authors.forename: Tarek
authors.initials: T
authors.lastname: Rebai
authors.affiliation: Laboratory of Pharmacology, Faculty of Medicine of Sfax, University of Sfax, Sfax, Tunisia.
authors.forename: Zouheir
authors.initials: Z
authors.lastname: Sahnoun