title: National survey of pediatric hospitalizations due to Kawasaki disease and coronary artery aneurysms in the USA.
abstract: Several studies revealed the epidemiology of Kawasaki disease-related hospitalizations among children in the USA and other countries. However, disparities of developing coronary artery aneurysms by race/ethnicity, patient socioeconomic status, and geographic locations remain unknown in the USA. Hospital discharge record data of patients with Kawasaki disease aged 19 years or younger were obtained from the 2003, 2006, 2009, and 2012 Kid's Inpatient Database. The data were weighted to estimate the annual hospitalization rates with respect to age, gender, and race/ethnicity in the USA. Multivariable logistic regression was conducted to ascertain the factors associated with the development of coronary artery aneurysms. Total annual hospitalization rates of Kawasaki disease showed a decreasing trend, ranging from 6.54 per 100,000 children in 2003 to 6.11 per 100,000 children in 2012 (p < 0.001). The proportions of coronary artery aneurysms among patients with Kawasaki disease ranged from 2.25 to 3.20%. Factor associated with the development of coronary artery aneurysms was hospitals in West (OR 2.15, 95% CI 1.42-3.26). Race/ethnicity, health insurance status, and household income were not associated with the development of coronary artery aneurysms. Total hospitalization rates of Kawasaki disease showed a decreasing trend. Children admitted to hospitals in West region were more likely to develop coronary artery aneurysms.
authors.affiliation: Harvard T.H. Chan School of Public Health, 158 Longwood Avenue, Boston, 02115, USA. sunning_dale@yahoo.co.jp.|Department of General Pediatrics, National Center for Child Health and Development, Tokyo, Japan. sunning_dale@yahoo.co.jp.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Okubo
authors.affiliation: Harvard T.H. Chan School of Public Health, 158 Longwood Avenue, Boston, 02115, USA.|Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: Kotaro
authors.initials: K
authors.lastname: Nochioka
authors.affiliation: Department of General Pediatrics, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sakakibara
authors.affiliation: Harvard T.H. Chan School of Public Health, 158 Longwood Avenue, Boston, 02115, USA.
authors.forename: Marcia
authors.initials: M
authors.lastname: Testa
authors.affiliation: Division of Immunology, Boston Children's Hospital, Boston, MA, 02115, USA.
authors.forename: Robert P
authors.initials: RP
authors.lastname: Sundel
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003323:Coronary Aneurysm / Q000453:epidemiology* / Q000628:therapy*; D003331:Coronary Vessels / Q000473:pathology; D003625:Data Collection; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000453:epidemiology* / Q000628:therapy*; D010351:Patient Discharge; D010372:Pediatrics; D016896:Treatment Outcome; D014481:United States
keywords: Coronary artery aneurysm; Kawasaki disease; Kids Inpatient Database