title: MMP20 rs1784418 Protects Certain Populations against Caries.
abstract: This work aimed to further evaluate the association of MMP20 rs1784418 C>T and dental caries experience with the hypothesis that MMP20 rs1784418 C>T is a risk factor for dental caries. 184 children 4-7 years of age had their caries experience determined and buccal cheek swabs collected for DNA extraction to test for association with the MMP20 rs1784418 C>T using standard statistical approaches. A meta-analytic approach was also implemented to compile previous discrepant reports of the same association. We found an association between MMP20 rs1784418 C>T and dental caries experience in primary dentition (p = 0.01). The meta-analysis showed that this association appears to favor individuals born in Brazil and not Turkey. MMP20 rs1784418 C>T appears to protect against dental caries, but its effects are likely to be more marked in certain populations.
authors.affiliation: Department of Pediatric Dentistry, Faculty of Dentistry, University of Pernambuco, Recife, Brazil.
authors.forename: Arnôldo V A
authors.initials: AV
authors.lastname: Filho
authors.forename: Merilene S
authors.initials: MS
authors.lastname: Calixto
authors.forename: Kathleen
authors.initials: K
authors.lastname: Deeley
authors.forename: Neide
authors.initials: N
authors.lastname: Santos
authors.forename: Aronita
authors.initials: A
authors.lastname: Rosenblatt
authors.forename: Alexandre R
authors.initials: AR
authors.lastname: Vieira
mesh_terms: D001938:Brazil / Q000208:ethnology; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D004245:DMF Index; D003710:Demography; D003731:Dental Caries / Q000208:ethnology* / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000208:ethnology*; D060005:Genotyping Techniques; D006801:Humans; D053519:Matrix Metalloproteinase 20 / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D014094:Tooth, Deciduous; D014421:Turkey / Q000208:ethnology
chemical_list: C507111:MMP20 protein, human; D053519:Matrix Metalloproteinase 20