title: A Possible Link Between Rheumatoid Arthritis and Periodontitis: A Systematic Review and Meta-analysis.
abstract: Previous studies have shown that patients with rheumatoid arthritis (RA) have a higher susceptibility to periodontitis, but the results of individual studies remain controversial. The aim of the present meta-analysis was to comprehensively evaluate the association between RA and periodontitis. A systematic literature search was conducted in PubMed and EMBASE. Data were extracted using standardized forms, and odds ratios (OR) with 95% confidence intervals (CI) were calculated for each study. Pooled data were estimated by fixed- and random-effects models if appropriate. Eight case-control studies were included in the present study. Study size ranged from 104 to 151,569 participants. The prevalence of periodontitis in RA patients ranged from 15.5% to 100%, compared with 10.0% to 82.1% in controls. In group 1 (control) and group 2, the heterogeneity was 38% and 11%, respectively. Using fixed-effects analysis, the overall pooled estimates of the ORs for periodontitis were 4.68 (95% CI: 3.11-7.05) and 1.28 (95% CI: 1.24-1.33) in groups 1 and 2, respectively. This meta-analysis indicates that RA was significantly associated with increased overall risk of periodontitis.
authors.forename: Qingqin
authors.initials: Q
authors.lastname: Tang
authors.forename: Haitao
authors.initials: H
authors.lastname: Fu
authors.forename: Baodong
authors.initials: B
authors.lastname: Qin
authors.forename: Zhide
authors.initials: Z
authors.lastname: Hu
authors.forename: Yaoting
authors.initials: Y
authors.lastname: Liu
authors.forename: Yan
authors.initials: Y
authors.lastname: Liang
authors.forename: Lin
authors.initials: L
authors.lastname: Zhou
authors.forename: Zaixing
authors.initials: Z
authors.lastname: Yang
authors.forename: Renqian
authors.initials: R
authors.lastname: Zhong
mesh_terms: D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D010518:Periodontitis / Q000453:epidemiology / Q000209:etiology*; D012307:Risk Factors