title: Regenerable Radical-Trapping Tellurobistocopherol Antioxidants.
abstract: Tellurobistocopherols 9-11 were prepared by lithiation of the corresponding bromotocopherols, reaction with tellurium tetrachloride and reductive workup. Compounds 9-11 quenched linoleic-acid-derived peroxyl radicals much more efficiently than α-tocopherol in a chlorobenzene/water two-phase system. N-Acetylcysteine or tris(2-carboxylethyl)phosphine as co-antioxidants in the aqueous phase could regenerate the tellurobistocopherols and increase their inhibition times. Antioxidant 11 inhibited peroxidation for 7-fold longer than that recorded with α-tocopherol. Thiol consumption in the aqueous phase was monitored and found to be inversely related to the inhibition time.
authors.affiliation: Department of Chemistry-BMC, Uppsala University , Box 576, SE-751 23 Uppsala, Sweden.
authors.forename: Jia-Fei
authors.initials: JF
authors.lastname: Poon
authors.affiliation: Department of Chemistry-BMC, Uppsala University , Box 576, SE-751 23 Uppsala, Sweden.
authors.forename: Jiajie
authors.initials: J
authors.lastname: Yan
authors.affiliation: Department of Chemistry-BMC, Uppsala University , Box 576, SE-751 23 Uppsala, Sweden.
authors.forename: Vijay P
authors.initials: VP
authors.lastname: Singh
authors.affiliation: School of Chemistry, University of Bristol , Bristol BS8 1TS, United Kingdom.
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Gates
authors.affiliation: Department of Chemistry-BMC, Uppsala University , Box 576, SE-751 23 Uppsala, Sweden.
authors.forename: Lars
authors.identifier: 0000-0001-7751-629X
authors.initials: L
authors.lastname: Engman