title: Integrated analyses for genetic markers of polycystic ovary syndrome with 9 case-control studies of gene expression profiles.
abstract: Due to genetic heterogeneity and variable diagnostic criteria, genetic studies of polycystic ovary syndrome are particularly challenging. Furthermore, lack of sufficiently large cohorts limits the identification of susceptibility genes contributing to polycystic ovary syndrome. Here, we carried out a systematic search of studies deposited in the Gene Expression Omnibus database through August 31, 2016. The present analyses included studies with: 1) patients with polycystic ovary syndrome and normal controls, 2) gene expression profiling of messenger RNA, and 3) sufficient data for our analysis. Ultimately, a total of 9 studies with 13 datasets met the inclusion criteria and were performed for the subsequent integrated analyses. Through comprehensive analyses, there were 13 genetic factors overlapped in all datasets and identified as significant specific genes for polycystic ovary syndrome. After quality control assessment, there were six datasets remained. Further gene ontology enrichment and pathway analyses suggested that differentially expressed genes mainly enriched in oocyte pathways. These findings provide potential molecular markers for diagnosis and prognosis of polycystic ovary syndrome, and need in-depth studies on the exact function and mechanism in polycystic ovary syndrome.
authors.affiliation: Department of Biostatistics and Computational Biology, State Key Laboratory of Genetic Engineering, Department of Gynecology, Obstetrics and Gynecology Hospital, School of Life Sciences, Fudan University, Shanghai, China.
authors.forename: Chenqi
authors.initials: C
authors.lastname: Lu
authors.affiliation: Clinical and Translational Research Center of Shanghai First Maternity and Infant Health Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Science and Technology, Tongji University, Shanghai, China.
authors.forename: Xiaoqin
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Endocrinology, East Hospital, Tongji University School of Medicine, Tongji University, Shanghai, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Biostatistics and Computational Biology, State Key Laboratory of Genetic Engineering, Department of Gynecology, Obstetrics and Gynecology Hospital, School of Life Sciences, Fudan University, Shanghai, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Jiang
authors.affiliation: Clinical and Translational Research Center of Shanghai First Maternity and Infant Health Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Science and Technology, Tongji University, Shanghai, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Yu
authors.affiliation: Clinical and Translational Research Center of Shanghai First Maternity and Infant Health Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Science and Technology, Tongji University, Shanghai, China.
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of Biostatistics and Computational Biology, State Key Laboratory of Genetic Engineering, Department of Gynecology, Obstetrics and Gynecology Hospital, School of Life Sciences, Fudan University, Shanghai, China.
authors.forename: Hairong
authors.initials: H
authors.lastname: Hu
authors.affiliation: Department of Biostatistics and Computational Biology, State Key Laboratory of Genetic Engineering, Department of Gynecology, Obstetrics and Gynecology Hospital, School of Life Sciences, Fudan University, Shanghai, China.
authors.forename: Saihua
authors.initials: S
authors.lastname: Zheng
authors.affiliation: Department of Biostatistics and Computational Biology, State Key Laboratory of Genetic Engineering, Department of Gynecology, Obstetrics and Gynecology Hospital, School of Life Sciences, Fudan University, Shanghai, China.
authors.forename: Xuelian
authors.initials: X
authors.lastname: Li
authors.affiliation: Clinical and Translational Research Center of Shanghai First Maternity and Infant Health Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Science and Technology, Tongji University, Shanghai, China.
authors.forename: Guiying
authors.initials: G
authors.lastname: Wang
mesh_terms: D015415:Biomarkers; D016022:Case-Control Studies; D019295:Computational Biology / Q000379:methods; D030561:Databases, Nucleic Acid; D005260:Female; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D063990:Gene Ontology; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000235:genetics*; D015203:Reproducibility of Results; D059467:Transcriptome
chemical_list: D015415:Biomarkers
keywords: common markers; gene expression profile; integrated analysis; polycystic ovary syndrome; susceptibility