title: Association of Beta-2 Microglobulin with Inflammation and Dislipidemia in High-Flux Membrane Hemodialysis Patients.
abstract: BACKGROUND
  Higher than expected cardiovascular mortality in hemodialysis patients, has been attributed to dyslipidemia as well as inflammation. Beta2-Microglobulin (β2M) is an independent predictor of outcome for hemodialysis patients and a representative substance of middle molecules.
  
  
  RESULTS
  In 40 patients in high-flux membrane hemodialysis, we found negative correlation of β2M with high density lipoprotein (r=-0.73, p<0.001) and albumin (r= -0.53, p<0.001) and positive correlation with triglycerides (r=0.69, p<0.001), parathyroid hormone (r=0.58, p < 0.05) and phosphorus (r= 0.53, p<0.001). There was no correlation of β2M with C- reactive protein (CRP) and interleukin-6 (IL-6). During the follow-up period of three years, 6 out of 40 patients have died from cardiovascular events.
  
  
  CONCLUSIONS
  In high-flux membrane hemodialysis patients, we observed a significant relationship of β2M with dyslipidemia and mineral bone disorders, but there was no correlation with inflammation.
authors.affiliation: Clinic of Medical Biochemistry, University Clinical Center, Pristina, Republic of Kosova; Faculty of Medicine, University of Prishtina, Republic of Kosova.
authors.forename: Valdete
authors.initials: V
authors.lastname: Topçiu-Shufta
authors.affiliation: Faculty of Medicine, University of Prishtina, Republic of Kosova.
authors.forename: Ramë
authors.initials: R
authors.lastname: Miftari
authors.affiliation: Clinic of Medical Biochemistry, University Clinical Center, Pristina, Republic of Kosova.
authors.forename: Valdete
authors.initials: V
authors.lastname: Haxhibeqiri
authors.affiliation: Faculty of Medicine, University of Prishtina, Republic of Kosova.
authors.forename: Shpend
authors.initials: S
authors.lastname: Haxhibeqiri
mesh_terms: D000328:Adult; D000368:Aged; D050171:Dyslipidemias / Q000150:complications*; D005260:Female; D006801:Humans; D007249:Inflammation; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000150:complications / Q000628:therapy*; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D012709:Serum Albumin; D055815:Young Adult; D001613:beta 2-Microglobulin / Q000097:blood*
chemical_list: D008075:Lipoproteins, HDL; D012709:Serum Albumin; D001613:beta 2-Microglobulin
keywords: beta-2 microglobulin; cardiovascular diseases; dyslipidemia; hemodialysis; inflammation