title: Outbreak of G2P[4] rotavirus gastroenteritis in a retirement community, Brazil, 2015: An important public health risk?
abstract: The present study described a group A rotavirus (RVA) outbreak in an age-care facility in Brazil, using epidemiologic and molecular diagnostic methods. A descriptive clinical, epidemiological and environmental investigation was conducted. Stool samples were collected and screened for RVA, Norovirus (NoV), Enteric Adenovirus 40/41 (AdV 40/41) and Astrovirus (AstV) using ELISA, RT-PCR, qRT-PCR, electron microscopy and sequencing methods. Outbreak occurred during 26th-29th October, 2015; 28 individuals affected (22 residents; 6 staff). The attack rate was 25.9% and 8.5% among residents (median-age: 85.5 years) and staff (median-age: 28 years), respectively. Female staff was identified as the index case. RVA G2P[4] genotype was detected in 87.5% (7/8). Genetic analysis demonstrated that the outbreak involved one single strain, suggesting a common-source infection. RVA should be considered during outbreaks investigations in residential facilities, and raise the question if the current licensed RVA vaccines for children could also be helpful for the elderly.
authors.affiliation: Enteric Disease Laboratory, Virology Center, Adolfo Lutz Institute, São Paulo, Brazil. Electronic address: driluchs@gmail.com.
authors.forename: Adriana
authors.initials: A
authors.lastname: Luchs
authors.affiliation: Foodboorne Diseases Epidemiological Surveillance, Center for Disease Control, Health Surveillance Management, Municipal Department of São Paulo Health, São Paulo, Brazil.
authors.forename: Geraldine
authors.initials: G
authors.lastname: Madalosso
authors.affiliation: Enteric Disease Laboratory, Virology Center, Adolfo Lutz Institute, São Paulo, Brazil.
authors.forename: Audrey
authors.initials: A
authors.lastname: Cilli
authors.affiliation: Enteric Disease Laboratory, Virology Center, Adolfo Lutz Institute, São Paulo, Brazil.
authors.forename: Simone Guadagnucci
authors.initials: SG
authors.lastname: Morillo
authors.affiliation: Santo Amaro and Cidade Ademar Regional Surveillance, Regional Health Coordinating, São Paulo, Brazil.
authors.forename: Sandra Regina
authors.initials: SR
authors.lastname: Martins
authors.affiliation: Enteric Disease Laboratory, Virology Center, Adolfo Lutz Institute, São Paulo, Brazil.
authors.forename: Karen Aparecida Farias
authors.initials: KAF
authors.lastname: de Souza
authors.affiliation: Eletron Microscopy Laboratory, Interdisciplinary Procedures Center, Adolfo Lutz Institute, São Paulo, Brazil.
authors.forename: Gislene Mitsue
authors.initials: GM
authors.lastname: Namiyama
authors.affiliation: Eletron Microscopy Laboratory, Interdisciplinary Procedures Center, Adolfo Lutz Institute, São Paulo, Brazil.
authors.forename: Cláudia Regina
authors.initials: CR
authors.lastname: Gonçalves
authors.affiliation: Enteric Disease Laboratory, Virology Center, Adolfo Lutz Institute, São Paulo, Brazil.
authors.forename: Rita de Cássia Compagnoli
authors.initials: RCC
authors.lastname: Carmona
authors.affiliation: Enteric Disease Laboratory, Virology Center, Adolfo Lutz Institute, São Paulo, Brazil. Electronic address: timenetsky.m@gmail.com.
authors.forename: Maria do Carmo Sampaio Tavares
authors.initials: MDCST
authors.lastname: Timenetsky
mesh_terms: D000328:Adult; D000369:Aged, 80 and over; D001938:Brazil; D004196:Disease Outbreaks; D005243:Feces / Q000821:virology; D005260:Female; D005759:Gastroenteritis / Q000453:epidemiology / Q000821:virology; D005838:Genotype; D006801:Humans; D008297:Male; D029322:Norovirus / Q000302:isolation & purification; D011634:Public Health; D012179:Retirement; D012307:Risk Factors; D012401:Rotavirus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D012400:Rotavirus Infections / Q000453:epidemiology / Q000821:virology
keywords: Elderly; Gastroenteritis; Genptyping; Rotavirus; Surveillance