title: High-speed and high-sensitivity parallel spectral-domain optical coherence tomography using a supercontinuum light source.
abstract: The three most important metrics in optical coherence tomography (OCT) are resolution, speed, and sensitivity. Because there is a complex interplay between these metrics, no previous work has obtained the best performance in all three metrics simultaneously. We demonstrate that a high-power supercontinuum source, in combination with parallel spectral-domain OCT, achieves an unparalleled combination of resolution, speed, and sensitivity. This system captures cross-sectional images spanning 4  mm×0.5  mm at 1,024,000 lines/s with 2×14  μm resolution (axial×transverse) at a sensitivity of 113 dB. Imaging using the proposed system is demonstrated on highly differentiated human bronchial epithelial cells to capture and spatially localize ciliary dynamics.
authors.forename: Jessica
authors.initials: J
authors.lastname: Barrick
authors.forename: Ana
authors.initials: A
authors.lastname: Doblas
authors.forename: Michael R
authors.initials: MR
authors.lastname: Gardner
authors.forename: Patrick R
authors.initials: PR
authors.lastname: Sears
authors.forename: Lawrence E
authors.initials: LE
authors.lastname: Ostrowski
authors.forename: Amy L
authors.initials: AL
authors.lastname: Oldenburg