title: Metal homeostasis in infectious disease: recent advances in bacterial metallophores and the human metal-withholding response.
abstract: A tug-of-war between the mammalian host and bacterial pathogen for nutrients, including first-row transition metals (e.g. Mn, Fe, Zn), occurs during infection. Here we present recent advances about three metal-chelating metabolites that bacterial pathogens deploy when invading the host: staphylopine, staphyloferrin B, and enterobactin. These highlights provide new insights into the mechanisms of bacterial metal acquisition and regulation, as well as the contributions of host-defense proteins during the human innate immune response. The studies also underscore that the chemical composition of the microenvironment at an infection site can influence bacterial pathogenesis and the innate immune system.
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
authors.forename: Wilma
authors.initials: W
authors.lastname: Neumann
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
authors.forename: Anmol
authors.initials: A
authors.lastname: Gulati
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: lnolan@mit.edu.
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Nolan
mesh_terms: D001419:Bacteria / Q000378:metabolism*; D001424:Bacterial Infections / Q000378:metabolism*; D002614:Chelating Agents / Q000378:metabolism*; D006706:Homeostasis; D054884:Host-Pathogen Interactions; D006801:Humans; D008670:Metals / Q000378:metabolism*
chemical_list: D002614:Chelating Agents; D008670:Metals