title: High Mass Ion Detection with Charge Detector Coupled to Rectilinear Ion Trap Mass Spectrometer.
abstract: Conventional linear ion trap mass analyzers (LIT-MS) provide high ion capacity and show their MSnability; however, the detection of high mass ions is still challenging because LIT-MS with secondary electron detectors (SED) cannot detect high mass ions. To detect high mass ions, we coupled a charge detector (CD) to a rectilinear ion trap mass spectrometer (RIT-MS). Immunoglobulin G ions (m/z ~150,000) are measured successfully with controlled ion kinetic energy. In addition, when mass-to-charge (m/z) ratios of singly charged ions exceed 10 kTh, the detection efficiency of CD is found to be greater than that of SED. The CD can be coupled to LIT-MS to extend the detection mass range and provide the potential to perform MSnof high mass ions inside the ion trap. Graphical Abstract ᅟ.
authors.affiliation: Department of Physics, National Dong Hwa University, Shoufeng, Hualien, Taiwan, 97401, Republic of China.
authors.forename: Avinash A
authors.initials: AA
authors.lastname: Patil
authors.affiliation: Department of Physics, National Dong Hwa University, Shoufeng, Hualien, Taiwan, 97401, Republic of China.|AcroMass technologies Inc., Hukou, Hsinchu, Taiwan, 30352, Republic of China.
authors.forename: Szu-Wei
authors.initials: SW
authors.lastname: Chou
authors.affiliation: Department of Physics, National Dong Hwa University, Shoufeng, Hualien, Taiwan, 97401, Republic of China.
authors.forename: Pei-Yu
authors.initials: PY
authors.lastname: Chang
authors.affiliation: Department of Physics, National Dong Hwa University, Shoufeng, Hualien, Taiwan, 97401, Republic of China.
authors.forename: Chen-Wei
authors.initials: CW
authors.lastname: Lee
authors.affiliation: AcroMass technologies Inc., Hukou, Hsinchu, Taiwan, 30352, Republic of China.
authors.forename: Chun-Yen
authors.initials: CY
authors.lastname: Cheng
authors.affiliation: Institute of Physics, Academia Sinica, Taipei, Taiwan, Republic of China.
authors.forename: Ming-Lee
authors.initials: ML
authors.lastname: Chu
authors.affiliation: Department of Physics, National Dong Hwa University, Shoufeng, Hualien, Taiwan, 97401, Republic of China. pengw@gms.ndhu.edu.tw.
authors.forename: Wen-Ping
authors.initials: WP
authors.lastname: Peng
keywords: Buffer gas pressure; Charge detector; High mass proteins; LDI/MALDI ions; Noise rejection; Orthogonal wavelet packet decomposition; Quadrupole ion guide; Scan rate; Voltage-scan rectilinear ion trap mass analyzer