title: Design, Conformation, and Crystallography of 2-Naphthyl Phenyl Ethers as Potent Anti-HIV Agents.
abstract: Catechol diethers that incorporate a 7-cyano-2-naphthyl substituent are reported as non-nucleoside inhibitors of HIV-1 reverse transcriptase (NNRTIs). Many of the compounds have 1-10 nM potencies toward wild-type HIV-1. An interesting conformational effect allows two unique conformers for the naphthyl group in complexes with HIV-RT. X-ray crystal structures for4aand4fillustrate the alternatives.
authors.affiliation: Department of Chemistry, Yale University , New Haven, Connecticut 06520-8107, United States.
authors.forename: Won-Gil
authors.initials: WG
authors.lastname: Lee
authors.affiliation: Department of Pharmacology, Yale University School of Medicine , New Haven, Connecticut 06520-8066, United States.
authors.forename: Albert H
authors.initials: AH
authors.lastname: Chan
authors.affiliation: Department of Pharmacology, Yale University School of Medicine , New Haven, Connecticut 06520-8066, United States.
authors.forename: Krasimir A
authors.initials: KA
authors.lastname: Spasov
authors.affiliation: Department of Pharmacology, Yale University School of Medicine , New Haven, Connecticut 06520-8066, United States.
authors.forename: Karen S
authors.initials: KS
authors.lastname: Anderson
authors.affiliation: Department of Chemistry, Yale University , New Haven, Connecticut 06520-8107, United States.
authors.forename: William L
authors.initials: WL
authors.lastname: Jorgensen
keywords: Anti-HIV agents; NNRTIs; protein crystallography