title: Long non-coding RNA HNF1A-AS1 up-regulation in non-small cell lung cancer correlates to poor survival.
abstract: Accumulating studies have focused on the role of the newly identified lncRNAs in the tumor. We aimed to investigate the clinical correlation between long non-coding RNA HNF1A-AS (HNF1A-AS1) expression and non-small cell lung cancer (NSCLC).
  
  
  
  Real-time polymerase chain reaction (PCR) was employed to detect HNF1A-AS expression in NSCLC tissues and corresponding adjacent tissues. The c2-test was used to compare the clinicopathological characteristics between different groups. Survival analysis was performed using the Kaplan-Meier method. The univariate and multivariate analyses were performed to investigate the prognostic significance of HNF1A-AS for NSCLC.
  
  
  
  The level of HNF1A-AS was higher in tumor tissues than that in normal tissues (p < 0.01). In addition, HNF1A-AS level was significantly associated with TNM stage (p = 0.002) and Lymph node metastasis (p = 0.005). Kaplan-Meier analysis indicated that a high level of HNF1A-AS expression predicted unfavorable overall survival (p < 0.001). The univariate and multivariate analysis identified HNF1A-AS as an independent poor prognostic factor for overall survival in NSCLC patients (p < 0.05).
  
  
  
  These results demonstrated that overexpression of HNF1A-AS might act a poor prognosis indicator in patients with NSCLC.
authors.affiliation: Department of Thoracic Surgery, Chinese PLA General Hospital, Beijing, China. sunnny301@126.com.
authors.forename: Y-F
authors.initials: YF
authors.lastname: Ma
authors.forename: T
authors.initials: T
authors.lastname: Liang
authors.forename: C-R
authors.initials: CR
authors.lastname: Li
authors.forename: Y-J
authors.initials: YJ
authors.lastname: Li
authors.forename: S
authors.initials: S
authors.lastname: Jin
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics*; D051538:Hepatocyte Nuclear Factor 1-alpha; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D062085:RNA, Long Noncoding / Q000235:genetics*; D015854:Up-Regulation
chemical_list: D014408:Biomarkers, Tumor; C496487:HNF1A protein, human; D051538:Hepatocyte Nuclear Factor 1-alpha; D062085:RNA, Long Noncoding