title: Oral Contrast-Enhanced Gastric Ultrasonography in the Assessment of Gastric Lesions: A Large-Scale Multicenter Study.
abstract: To determine the diagnostic efficiency of oral contrast-enhanced gastric ultrasonography in the evaluation of gastric lesions, based on large-scale multicenter study.
  
  
  
  The study enrolled 383,945 patients with suspect gastric lesions who underwent complete oral contrast-enhanced gastric ultrasonography and endoscopic evaluation. Two operators, unaware of the results of other diagnostic procedures, performed each examination independently. The accuracies of conventional ultrasonography, oral contrast-enhanced gastric ultrasonography, and upper gastrointestinal endoscopy were determined.
  
  
  
  After oral contrast, the anatomy of the stomach and morphologic features of gastric lesions were clearly visualized. The sensitivities, specificities, positive predictive values, negative predictive values and accuracies of oral contrast-enhanced ultrasonography in detecting the sites, sizes, numbers, and the extent of gastric lesions,were similar to those of upper gastrointestinal endoscopy (P > .05) and far greater than those of conventional ultrasonography (P < .01). Moreover, oral contrast-enhanced ultrasonography was far better than upper gastrointestinal endoscopy (P < .01) and was better than conventional ultrasonography (P < .05) in detecting the submucosal abnormalities (<5mm) and the adjacent structures abnormalities identified in surgical pathology. However, oral contrast-enhanced ultrasonography was a bit poorer than upper gastrointestinal endoscopy (P < .05) and far better than conventional ultrasonography (P < .01) in detecting the minor mucosal abnormalities (<5mm).
  
  
  
  Oral contrast-enhanced gastric ultrasonography is superior to conventional gastric ultrasonography in defining the anatomic location and extension of gastric lesions. Its diagnostic performance is not worse than upper gastrointestinal endoscopy and it can be used as a useful supplement to upper gastrointestinal endoscopy.
authors.affiliation: Department of Ultrasound, The First People's Hospital of Yancheng, Yancheng, P.R. China.|Department of Ultrasound, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, P.R. China.|Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, P.R. China.
authors.forename: Xiao-Zhi
authors.initials: XZ
authors.lastname: Zheng
authors.affiliation: Department of Ultrasound, Pukou Hospital (The Fourth Affiliated Hospital with Nanjing Medical University), Nanjing, P.R. China.
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Zhang
authors.affiliation: Department of Ultrasound, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, P.R. China.|Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, P.R. China.
authors.forename: Xin-Ping
authors.initials: XP
authors.lastname: Wu
authors.affiliation: Department of Ultrasound, The First People's Hospital of Huzhou, Huzhou, P.R. China.
authors.forename: Wen-Ming
authors.initials: WM
authors.lastname: Lu
authors.affiliation: Department of Ultrasound, The First People's Hospital of Yancheng, Yancheng, P.R. China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Ultrasound, Jiangsu Province Tumor Hospital, Nanjing, P.R. China.
authors.forename: Xu-Yan
authors.initials: XY
authors.lastname: Tan
keywords: conventional ultrasonography; gastric; gastrointestinal endoscopy; large sample; multicenter; oral contrast‐enhanced ultrasonography