title: Patient-specific structural effects on hemodynamics in the ischemic lower limb artery.
abstract: Lower limb peripheral artery disease is a prevalent chronic non-communicable disease without obvious symptoms. However, the effect of ischemic lower limb peripheral arteries on hemodynamics remains unclear. In this study, we investigated the variation of the hemodynamics caused by patient-specific structural artery characteristics. Computational fluid dynamic simulations were performed on seven lower limb (including superficial femoral, deep femoral and popliteal) artery models that were reconstructed from magnetic resonance imaging. We found that increased wall shear stress (WSS) was mainly caused by the increasing severity of stenosis, bending, and branching. Our results showed that the increase in the WSS value at a stenosis at the bifurcation was 2.7 Pa. In contrast, the isolated stenosis and branch caused a WSS increase of 0.7 Pa and 0.5 Pa, respectively. The WSS in the narrow popliteal artery was more sensitive to a reduction in radius. Our results also demonstrate that the distribution of the velocity and pressure gradient are highly structurally related. At last, Ultrasound Doppler velocimeter measured result was presented as a validation. In conclusion, the distribution of hemodynamics may serve as a supplement for clinical decision-making to prevent the occurrence of a morbid or mortal ischemic event.
authors.affiliation: Southern Medical University, Institutes of Clinical Anatomy, Guangzhou, 510515, China.
authors.forename: Pengcheng
authors.initials: P
authors.lastname: Xu
authors.affiliation: Shenzhen Institute of Advance Technology, Research Center for Biomedical Information Technology, Chinese academic of science, Shenzhen, 518055, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.affiliation: Curacloud Corporation, Center of Medical Image Computing, 999 Third Ave, STE 700, Seattle, WA 98104, USA.
authors.forename: Qi
authors.initials: Q
authors.lastname: Song
authors.affiliation: Sun Yat-sen Memorial Hospital, Department of Endocrinology, Guangzhou, 510120, China.
authors.forename: Guishan
authors.initials: G
authors.lastname: Chen
authors.affiliation: The Chinese University of Hong Kong, Department of Imaging and Interventional Radiology, Hong Kong, 999077, China.
authors.forename: Defeng
authors.initials: D
authors.lastname: Wang
authors.affiliation: Shenzhen Institute of Advance Technology, Research Center for Biomedical Information Technology, Chinese academic of science, Shenzhen, 518055, China.
authors.forename: Heye
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Sun Yat-sen Memorial Hospital, Department of Endocrinology, Guangzhou, 510120, China.
authors.forename: Li
authors.initials: L
authors.lastname: Yan
authors.affiliation: Sun Yat-sen Memorial Hospital, Department of Endocrinology, Guangzhou, 510120, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Liu
authors.affiliation: Southern Medical University, Institutes of Clinical Anatomy, Guangzhou, 510515, China.
authors.forename: Wenhua
authors.initials: W
authors.lastname: Huang
mesh_terms: D001158:Arteries / Q000000981:diagnostic imaging / Q000502:physiology*; D001783:Blood Flow Velocity; D006439:Hemodynamics; D006801:Humans; D017078:Laser-Doppler Flowmetry; D008955:Models, Cardiovascular; D058729:Peripheral Arterial Disease / Q000503:physiopathology*; D033081:Shear Strength; D018608:Ultrasonography, Doppler