title: Prognostic value ofp53mutation for poor outcome of Asian primary liver cancer patients: evidence from a cohort study and meta-analysis of 988 patients.
abstract: Several previous studies have investigated the association between genep53(p53) mutation and the poor outcome of primary liver cancer (PLC) patients; however, the results remain inconsistent. In the present study,p53mutation in 60 paired tumor and corresponding nontumor tissues derived from a cohort of 60 PLC patients was systematically analyzed. The results showed thatp53mutation was only an independent risk factor for overall survival (OS), not for recurrence-free survival (RFS), and a meta-analysis was performed to verify this. Online databases were searched up to July 1, 2016. Studies about the association betweenp53mutation and the postsurgery survival of PLC patients were collected. A total of 988 patients from eight studies were analyzed; among them, 341 (34.51%) patients hadp53mutation. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were 2.03 (1.64, 2.41) and 2.36 (1.31, 3.42) for OS and RFS, respectively. In conclusion, both the cohort study and meta-analysis suggested that thep53mutation was associated with postsurgery OS in Asian PLC patients. However, the relationship betweenp53mutation and recurrence should be confirmed by further studies.
authors.affiliation: Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou.
authors.forename: Xiajie
authors.initials: X
authors.lastname: Wen
authors.affiliation: Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou; Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center.
authors.forename: Fengmin
authors.initials: F
authors.lastname: Lu
authors.affiliation: Beijing Artificial Liver Treatment and Training Center, Beijing Youan Hospital, Capital Medical University, Beijing, China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Liu
keywords: meta-analysis; p53; primary liver cancer; survival