title: Reflections on HLA Epitope-Based Matching for Transplantation.
abstract: HLA antibodies are primary causes of transplant rejection; they recognize epitopes that can be structurally defined by eplets. There are many reviews about HLA epitope-based matching in transplantation. This article describes some personal reflections about epitopes including a historical perspective of HLA typing at the antigen and allele levels, the repertoires of antibody-verified HLA epitopes, the use of HLAMatchmaker in determining the specificities of antibodies tested in different assays, and, finally, possible strategies to control HLA antibody responses.
authors.affiliation: University of Pittsburgh Medical Center , Pittsburgh, PA , USA.
authors.forename: Rene J
authors.initials: RJ
authors.lastname: Duquesnoy
keywords: HLA; antibody; epitope; eplet; mismatch acceptability