title: EGF-R Protein Expression and Gene Amplification do not Correlate in Pancreas Cancer.
abstract: In a series of 13 pancreas cancer specimens, EGF-R was evaluated by means of both immunohistochemistry (IHC) for protein expression and FISH for genetic amplification. The results were discording in 7 cases (IHC positive, FISH negative), while in the remaining 6 cases both IHC and FISH were negative. The possible clinical implications of these results are discussed.
authors.affiliation: Surgical Clinic, Department of Medical and Surgical Sciences, Brescia University, III Chirurgia, Spedali Civili di Brescia, P.le Spedali Civili, 1, 25123, Brescia, Italy.
authors.forename: Gian Luca
authors.initials: GL
authors.lastname: Baiocchi
authors.affiliation: Department of Pathology, Brescia University.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Villanacci
authors.affiliation: Department of Pathology, Brescia University.
authors.forename: Elisa
authors.initials: E
authors.lastname: Rossi
authors.affiliation: Surgical Clinic, Department of Medical and Surgical Sciences, Brescia University, III Chirurgia, Spedali Civili di Brescia, P.le Spedali Civili, 1, 25123, Brescia, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Zanotti
authors.affiliation: Surgical Clinic, Department of Medical and Surgical Sciences, Brescia University, III Chirurgia, Spedali Civili di Brescia, P.le Spedali Civili, 1, 25123, Brescia, Italy.
authors.forename: Stefano Maria
authors.initials: SM
authors.lastname: Giulini
keywords: EGF-R; FISH; cancer; immunohistochemistry; pancreas