title: The Ongoing Genetic Adaptation of Streptococcus pneumoniae.
abstract: Streptococcus pneumoniaehas demonstrated a remarkable ability to adapt during the conjugate vaccine era. The increasing incidence of serotype 35B disease and emergence of a multidrug-resistant clone reported in this issue of theJournal of Clinical Microbiology(L. Olarte et al., J Clin Microbiol 55:724-734, 2017, https://doi.org/10.1128/JCM.01778-16) underscore the limitations of pneumococcal vaccines that target the polysaccharide capsule.
authors.affiliation: Department of Laboratory Medicine, Cleveland Clinic, Cleveland, Ohio, USA richtes@ccf.org.
authors.forename: Sandra S
authors.initials: SS
authors.lastname: Richter
authors.affiliation: Departments of Medicine and Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA, and the Medical Care Line (Infectious Disease Section), Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas, USA.
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Musher
mesh_terms: D006801:Humans; D011008:Pneumococcal Infections / Q000453:epidemiology*; D022242:Pneumococcal Vaccines / Q000276:immunology; D065288:Serogroup; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000235:genetics*; D018074:Vaccines, Conjugate / Q000276:immunology
chemical_list: D022242:Pneumococcal Vaccines; D018074:Vaccines, Conjugate