title: Evaluation of salicylic acid peeling in comparison with topical tretinoin in the treatment of postinflammatory hyperpigmentation.
abstract: BACKGROUND
  Postinflammatory hyperpigmentation (PIH) is an acquired hyperpigmentation that involves areas of prior cutaneous inflammation. In addition to prevention, there are a variety of medications and procedures used to treat PIH.
  
  
  OBJECTIVE
  The aim of this work was to evaluate the efficacy, tolerability, and safety of salicylic acid peeling in comparison with topical tretinoin in the treatment of PIH.
  
  
  METHODS
  This study included forty-five patients with PIH lesions. The patients were divided into three groups, group I was treated with salicylic acid peeling 20-30%, group II was treated with topical tretinoin 0.1%, and group III was treated with combination of salicylic acid peel and topical tretinoin. The patients were assessed clinically to evaluate the efficacy, tolerability, and safety of the treatment. Dermoscopy was carried out to the recurrent or nonimproved cases only.
  
  
  RESULTS
  Combination of salicylic acid peel and topical tretinoin treatment showed significant clinical improvement of PIH than each treatment alone with no complications. There was no significant difference in the recurrence rate between the three groups. There was nonsignificant difference between the efficacy of the treatment and the PIH type in the studied groups. There was nonsignificant difference between the efficacy of the treatment and the duration of the PIH except for group III.
  
  
  CONCLUSIONS
  Combination treatment modality is believed to be preferred in the treatment of PIH due to its higher efficacy than single treatment alone, with well tolerability, less side effects, and low recurrence rate.
authors.affiliation: Dermatology and Venereology, Faculty of Medicine, Tanta University Hospital, Tanta, Egypt.
authors.forename: Basma Morad
authors.initials: BM
authors.lastname: Mohamed Ali
authors.affiliation: Dermatology and Venereology, Faculty of Medicine, Tanta University Hospital, Tanta, Egypt.
authors.forename: Shereen Farouk
authors.initials: SF
authors.lastname: Gheida
authors.affiliation: Pharmacology and Toxicology, Faculty of Pharmacy, Tanta University, Tanta, Egypt.
authors.forename: Nageh Ahmed
authors.initials: NA
authors.lastname: El Mahdy
authors.affiliation: Dermatology and Venereology, Faculty of Medicine, Tanta University Hospital, Tanta, Egypt.
authors.forename: Shery Nashaat
authors.initials: SN
authors.lastname: Sadek
mesh_terms: D000279:Administration, Cutaneous; D000293:Adolescent; D000328:Adult; D000368:Aged; D002615:Chemexfoliation / Q000009:adverse effects; D002648:Child; D003131:Combined Modality Therapy / Q000009:adverse effects; D046169:Dermoscopy; D005260:Female; D006801:Humans; D017495:Hyperpigmentation / Q000000981:diagnostic imaging / Q000209:etiology / Q000628:therapy*; D007249:Inflammation / Q000150:complications; D007641:Keratolytic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D020156:Salicylic Acid / Q000009:adverse effects / Q000627:therapeutic use*; D014212:Tretinoin / Q000008:administration & dosage* / Q000009:adverse effects; D055815:Young Adult
chemical_list: D007641:Keratolytic Agents; D014212:Tretinoin; D020156:Salicylic Acid
keywords: dermoscope; postinflammatory hyperpigmentation; salicylic acid; tretinoin