title: The immunohistochemical and urodynamic evaluation towards the collagen-coated and non-coated polypropylene meshes implanted in the pelvic wall of the rats.
abstract: Our aim is to study the inflammatory response towards the collagen-coated and non-coated polypropylene meshes in rats and the urodynamic investigation post-operatively. Forty-two female Sprague Dawley were divided into 7 groups of 6 rats; Control, Day 7 and 30 for Sham, Avaulta Plus (MPC), Perigee (MP). UDS were taken at days 7 and 30. Mesh with the vagina and bladder wall was removed and sent for immunohistochemical examination. Results showed intense inflammatory reaction on day 7 in the study groups which decreased on day 30. IL-1, TNF-α, MMP-2 and CD31 were observed to decrease from day 7 to day 30. NGF was almost normal on day 30 in all groups. UDS showed no difference in voiding pressure. Both Study and Sham groups had shorter voiding interval (VI) on day 7 but significantly lower in MPC. VI had significantly increased on day 30 in all groups. Voided volume was significantly lower in the mesh groups even when an increase was seen on day 30. In conclusion, the higher levels of IL-1, TNF-α and MMP-2 in collagen-coated polypropylene mesh imply greater inflammation than the non-coated polypropylene mesh. Mesh implantation can lead to shorter voiding interval and smaller bladder capacity.
authors.affiliation: Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Keelung, Medical Center, Keelung, Taiwan, Republic of China.|Division of Urogynecology, Department of Obstetrics and Gynecology, Linkou, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan, Republic of China.|Chang Gung University, School of Medicine, Taoyuan, Taiwan, Republic of China.
authors.forename: Tsia-Shu
authors.initials: TS
authors.lastname: Lo
authors.affiliation: Division of Urogynecology, Department of Obstetrics and Gynecology, Linkou, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan, Republic of China.|Chang Gung University, School of Medicine, Taoyuan, Taiwan, Republic of China.
authors.forename: Yi-Hao
authors.initials: YH
authors.lastname: Lin
authors.affiliation: Department of Obstetrics and Gynaecology, Hospital Sultanah Nur Zahirah, Kuala Terengganu, Malaysia.|Fellow of the Division of Urogynaecology, Department of Obstetrics &Gynaecology, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan, Republic of China.
authors.forename: Faridah Mohd
authors.initials: FM
authors.lastname: Yusoff
authors.affiliation: Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Keelung, Medical Center, Keelung, Taiwan, Republic of China.|Division of Urogynecology, Department of Obstetrics and Gynecology, Linkou, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan, Republic of China.
authors.forename: Hsiao-Chien
authors.initials: HC
authors.lastname: Chu
authors.affiliation: Division of Urogynecology, Department of Obstetrics and Gynecology, Linkou, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan, Republic of China.|Fellow of the Division of Urogynaecology, Department of Obstetrics &Gynaecology, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan, Republic of China.
authors.forename: Wu-Chiao
authors.initials: WC
authors.lastname: Hsieh
authors.affiliation: Fellow of the Division of Urogynaecology, Department of Obstetrics &Gynaecology, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan, Republic of China.|Department of Obstetrics and Gynecology, Dr. Pablo O. Torre Memorial Hospital, Bacolod City, Philippines.
authors.forename: Ma Clarissa
authors.initials: MC
authors.lastname: Uy-Patrimonio
mesh_terms: D000818:Animals; D020099:Coated Materials, Biocompatible; D003094:Collagen; D005260:Female; D008422:Materials Testing; D010388:Pelvis / Q000601:surgery*; D011126:Polypropylenes; D051381:Rats; D017207:Rats, Sprague-Dawley; D013526:Surgical Mesh; D014563:Urodynamics
chemical_list: D020099:Coated Materials, Biocompatible; D011126:Polypropylenes; D003094:Collagen