title: Mix and Match: Coassembly of Amphiphilic Dendrimers and Phospholipids Creates Robust, Modular, and Controllable Interfaces.
abstract: Self-assembly of supramolecular structures has become an attractive means to create new biologically inspired materials and interfaces. We report the first robust hybrid bilayer systems readily coassembled from amphiphilic dendrimers and a naturally occurring phospholipid. Both concentration and generation of the dendrimers have direct impacts on the biophysical properties of the coassemblies. Raising the dendrimer concentration increases the hybrid bilayer stability, while changes in the generation and the concentration of the embedded dendrimers impact the fluidity of the coassembled systems. Multivalent dendrimer amine terminals allow for nondestructive in situ derivatization, providing a convenient approach to decorate and modulate the local environment of the hybrid bilayer. The coassembly of lipid/dendrimer interfaces offers a unique platform for the creation of hybrid systems with modular and precisely controllable behavior for further applications in sensing and drug delivery.
authors.forename: Samuel S
authors.identifier: http://orcid.org/0000-0002-7727-0450
authors.initials: SS
authors.lastname: Hinman
authors.forename: Charles J
authors.initials: CJ
authors.lastname: Ruiz
authors.affiliation: Aix-Marseille Université, CNRS, Centre Interdisciplinaire de Nanoscience de Marseille, UMR 7325, Equipe Labellisée Ligue Contre le Cancer, 13288 Marseille, France.
authors.forename: Yu
authors.initials: Y
authors.lastname: Cao
authors.forename: Meghann C
authors.initials: MC
authors.lastname: Ma
authors.affiliation: Aix-Marseille Université, CNRS, Centre Interdisciplinaire de Nanoscience de Marseille, UMR 7325, Equipe Labellisée Ligue Contre le Cancer, 13288 Marseille, France.
authors.forename: Jingjie
authors.initials: J
authors.lastname: Tang
authors.affiliation: Molecular Simulation Engineering (MOSE) Laboratory, Department of Engineering and Architecture (DEA), Trieste University , 34127 Trieste, Italy.
authors.forename: Erik
authors.identifier: http://orcid.org/0000-0001-6092-6532
authors.initials: E
authors.lastname: Laurini
authors.affiliation: Molecular Simulation Engineering (MOSE) Laboratory, Department of Engineering and Architecture (DEA), Trieste University , 34127 Trieste, Italy.
authors.forename: Paola
authors.identifier: http://orcid.org/0000-0001-8129-1572
authors.initials: P
authors.lastname: Posocco
authors.affiliation: Aix-Marseille Université, CNRS, Centre Interdisciplinaire de Nanoscience de Marseille, UMR 7325, Equipe Labellisée Ligue Contre le Cancer, 13288 Marseille, France.
authors.forename: Suzanne
authors.initials: S
authors.lastname: Giorgio
authors.affiliation: Molecular Simulation Engineering (MOSE) Laboratory, Department of Engineering and Architecture (DEA), Trieste University , 34127 Trieste, Italy.
authors.forename: Sabrina
authors.identifier: http://orcid.org/0000-0001-8380-4474
authors.initials: S
authors.lastname: Pricl
authors.affiliation: Aix-Marseille Université, CNRS, Centre Interdisciplinaire de Nanoscience de Marseille, UMR 7325, Equipe Labellisée Ligue Contre le Cancer, 13288 Marseille, France.
authors.forename: Ling
authors.initials: L
authors.lastname: Peng
authors.forename: Quan
authors.identifier: http://orcid.org/0000-0003-0934-358X
authors.initials: Q
authors.lastname: Cheng
mesh_terms: D050091:Dendrimers / Q000737:chemistry*; D016503:Drug Delivery Systems; D010743:Phospholipids
chemical_list: D050091:Dendrimers; D010743:Phospholipids
keywords: amphiphilic dendrimers; dendrimer/lipid hybrid membrane; self-assembly; supramolecular coassembly; surface plasmon resonance