title: Increase of EEG Spectral Theta Power Indicates Higher Risk of the Development of Severe Cognitive Decline in Parkinson's Disease after 3 Years.
abstract: Objective:We investigated quantitative electroencephalography (qEEG) and clinical parameters as potential risk factors of severe cognitive decline in Parkinson's disease.Methods:We prospectively investigated 37 patients with Parkinson's disease at baseline and follow-up (after 3 years). Patients had no severe cognitive impairment at baseline. We used a summary score of cognitive tests as the outcome at follow-up. At baseline we assessed motor, cognitive, and psychiatric factors; qEEG variables [global relative median power (GRMP) spectra] were obtained by a fully automated processing of high-resolution EEG (256-channels). We used linear regression models with calculation of the explained variance to evaluate the relation of baseline parameters with cognitive deterioration.Results:The following baseline parameters significantly predicted severe cognitive decline: GRMP theta (4-8 Hz), cognitive task performance in executive functions and working memory.Conclusions:Combination of neurocognitive tests and qEEG improves identification of patients with higher risk of cognitive decline in PD.
authors.affiliation: Department of Neurology, Hospital of the University of Basel Basel, Switzerland.
authors.forename: Vitalii V
authors.initials: VV
authors.lastname: Cozac
authors.affiliation: Department of Neurology, Hospital of the University of BaselBasel, Switzerland; Department of Mathematics and Computer Science, University of BaselBasel, Switzerland.
authors.forename: Menorca
authors.initials: M
authors.lastname: Chaturvedi
authors.affiliation: Department of Neurology, Hospital of the University of Basel Basel, Switzerland.
authors.forename: Florian
authors.initials: F
authors.lastname: Hatz
authors.affiliation: Department of Neurology, Hospital of the University of Basel Basel, Switzerland.
authors.forename: Antonia
authors.initials: A
authors.lastname: Meyer
authors.affiliation: Department of Neurology, Hospital of the University of Basel Basel, Switzerland.
authors.forename: Peter
authors.initials: P
authors.lastname: Fuhr
authors.affiliation: Department of Neurology, Hospital of the University of Basel Basel, Switzerland.
authors.forename: Ute
authors.initials: U
authors.lastname: Gschwandtner
keywords: EEG; Parkinson’s disease; cognitive decline; cognitive tests; cohort study