title: Differences between WHO AND CDC early growth measurements in the assessment of Cystic Fibrosis clinical outcomes.
abstract: BACKGROUND
  Early childhood growth status has been used to predict long-term clinical outcomes in Cystic Fibrosis (CF) patients. Adulthood CF outcomes based on early weight-for-length (WFL) measurements, using either World Health Organization (WHO) or Centers for Disease Control (CDC) scales, have not been compared.
  
  
  METHODS
  Cystic Fibrosis Foundation registry patients were studied (n=3014). Participants were categorized at age two years as WFL <50th percentile on both WHO and CDC scales, ≥50th percentile on WHO but not CDC, or ≥50th percentile on both. Pulmonary function and overall survival were assessed at age 18years.
  
  
  RESULTS
  Stepwise gains in pulmonary function and lung transplant-free survival were noted across the three increasing WFL categories.
  
  
  CONCLUSIONS
  Children with CF who achieve higher WFL at age two years have improved pulmonary and survival outcomes into adulthood. CF providers should continue to utilize current early growth recommendations, with goal WFL ≥50th percentile on CDC growth charts before age two.
authors.affiliation: Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Benioff Children's Hospital, University of California, San Francisco, CA, United States.
authors.forename: Danielle
authors.initials: D
authors.lastname: Usatin
authors.affiliation: Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Benioff Children's Hospital, University of California, San Francisco, CA, United States.
authors.forename: Elizabeth H
authors.initials: EH
authors.lastname: Yen
authors.affiliation: Primary Children's Hospital, Salt Lake City, UT, United States.
authors.forename: Catherine
authors.initials: C
authors.lastname: McDonald
authors.affiliation: Division of Pediatric Pulmonology, Department of Pediatrics, Primary Children's Hospital, University of Utah School of Medicine, Salt Lake City, UT, United States.
authors.forename: Fadi
authors.initials: F
authors.lastname: Asfour
authors.affiliation: Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Primary Children's Hospital, University of Utah School of Medicine, Salt Lake City, UT, United States.
authors.forename: John
authors.initials: J
authors.lastname: Pohl
authors.affiliation: Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Primary Children's Hospital, University of Utah School of Medicine, Salt Lake City, UT, United States. Electronic address: Jacob.robson@hsc.utah.edu.
authors.forename: Jacob
authors.initials: J
authors.lastname: Robson
mesh_terms: D000293:Adolescent; D000886:Anthropometry / Q000379:methods*; D001827:Body Height; D002487:Centers for Disease Control and Prevention, U.S.; D002657:Child Development; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000175:diagnosis / Q000503:physiopathology; D005260:Female; D006128:Growth; D006801:Humans; D008297:Male; D017063:Outcome Assessment, Health Care / Q000379:methods / Q000592:standards; D012042:Registries / Q000706:statistics & numerical data; D012129:Respiratory Function Tests / Q000379:methods / Q000706:statistics & numerical data; D016019:Survival Analysis; D014481:United States / Q000453:epidemiology; D014944:World Health Organization
keywords: Cystic Fibrosis (CF); Forced Expiratory Volume in 1second percent predicted (FEV1(pp)); Growth standards; Survival; Weight-for-length (WFL)