title: Fabrication of basil seed gum nanoparticles as a novel oral delivery system of glutathione.
abstract: Plant derived polymers like mucilage have evoked great attention in the field of functional food ingredient delivery. The objective of this study was to evaluate the potential of basil seed gum nanoparticles (BSG NPs) as an oral delivery system for glutathione (GSH). BSG NPs (1-0.25mgml-1) were fabricated by ion gelling technique and calcium was used as a cross-linking agent (0.7-0.3mgml-1). The results showed that BSG NPs (298-595nm) have spherical shape and the relative viscosity revealed that the possibility of agglomeration of BSG NPs is low. The interaction between BSG and GSH was confirmed by FTIR and DSC studies. Entrapment and loading efficiency of BSG-GSH nanoparticles were in the range of 6.5-43% and 7-13%, respectively. GSH release in gastrointestinal environment showed release speed in pH 1.2 was lower in compared with pH 6.8. As a result, smaller amounts of GSH will be destroyed in the stomach during digestion time.
authors.affiliation: Department of Food Nanotechnology, Research Institute of Food Science and Technology, Mashhad, Iran; Food Hydrocolloids Research Centre, Department of Food Science and Technology, Ferdowsi University of Mashhad (FUM), PO Box 91775-1163, Mashhad, Iran.
authors.forename: Sara
authors.initials: S
authors.lastname: Naji-Tabasi
authors.affiliation: Food Hydrocolloids Research Centre, Department of Food Science and Technology, Ferdowsi University of Mashhad (FUM), PO Box 91775-1163, Mashhad, Iran. Electronic address: sma_razavi@yahoo.com.
authors.forename: Seyed Mohammad Ali
authors.initials: SMA
authors.lastname: Razavi
authors.affiliation: Food Hydrocolloids Research Centre, Department of Food Science and Technology, Ferdowsi University of Mashhad (FUM), PO Box 91775-1163, Mashhad, Iran.
authors.forename: Hossein
authors.initials: H
authors.lastname: Mehditabar
mesh_terms: D016503:Drug Delivery Systems; D065546:Drug Liberation; D005978:Glutathione / Q000008:administration & dosage*; D053758:Nanoparticles; D018649:Ocimum basilicum / Q000737:chemistry*; D053149:Plant Gums / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry
chemical_list: D053149:Plant Gums; D005978:Glutathione
keywords: Hydrocolloid; Intrinsic viscosity; Morphology; Nanotechnology; Peptide; Release