title: Volumetric and morphometric MRI findings in patients with mild traumatic brain injury.
abstract: OBJECTIVE
  This study compared cortical and sub-cortical volumes between patients with complicated (i.e. presence of intracranial abnormality on the day-of-injury CT) and uncomplicated (i.e. absence of intracranial abnormality) mild traumatic brain injury (MTBI) 4 weeks post-injury. The study hypothesized regionally decreased brain volumes and reduced cortical thickness in patients with complicated MTBIs compared with uncomplicated MTBI.
  
  
  METHODS
  This study was part of a larger 2 years cohort study on MTBI. Baseline clinical and magnetic resonance imaging (MRI) data were compared for those with complicated and uncomplicated MTBI. It identified 168 patients with MTBI (90 uncomplicated and 78 complicated), aged 16-65 years. 3T MRI-system (Signa HDxt, GE Medical Systems, Milwaukee, WI) and cortical reconstruction and volumetric segmentation by FreeSurfer software have been used.
  
  
  RESULTS
  No significant differences between uncomplicated and complicated MTBIs were found in neuroanatomic volumes and cortical thickness after controlling for age, gender and education. The complicated MTBI group showed larger ventricles compared with the uncomplicated group, but this effect diluted when adjusting for potential confounders.
  
  
  CONCLUSIONS
  The study findings suggest that the classification of complicated and uncomplicated MTBI may be too broad to differentiate volumetric and morphometric effects of injury in the early post-injury phase.
authors.affiliation: a Department of Physical Medicine and Rehabilitation , Oslo University Hospital , Oslo , Norway.
authors.forename: T
authors.initials: T
authors.lastname: Hellstrøm
authors.affiliation: b KG Jebsen Centre for Psychosis Research/Norwegian Centre for Mental Disorder Research (NORMENT), Division of Mental Health and Addiction , Oslo University Hospital , Oslo , Norway.|c Department of Psychology , University of Oslo , Oslo , Norway.
authors.forename: L T
authors.initials: LT
authors.lastname: Westlye
authors.affiliation: d Department of Radiology and Nuclear Medicine , Oslo University Hospital , Oslo , Norway.
authors.forename: A
authors.initials: A
authors.lastname: Server
authors.affiliation: c Department of Psychology , University of Oslo , Oslo , Norway.|e Sunnaas Rehabilitation Hospital, Department of Research , Nesoddtangen , Norway.
authors.forename: M
authors.initials: M
authors.lastname: Løvstad
authors.affiliation: f Oslo Centre for Biostatistics and Epidemiology, Research Support Services , Oslo University Hospital , Oslo , Norway.
authors.forename: C
authors.initials: C
authors.lastname: Brunborg
authors.affiliation: b KG Jebsen Centre for Psychosis Research/Norwegian Centre for Mental Disorder Research (NORMENT), Division of Mental Health and Addiction , Oslo University Hospital , Oslo , Norway.
authors.forename: M J
authors.initials: MJ
authors.lastname: Lund
authors.affiliation: g The Intervention Centre , Oslo University Hospital , Oslo , Norway.
authors.forename: W
authors.initials: W
authors.lastname: Nordhøy
authors.affiliation: b KG Jebsen Centre for Psychosis Research/Norwegian Centre for Mental Disorder Research (NORMENT), Division of Mental Health and Addiction , Oslo University Hospital , Oslo , Norway.
authors.forename: O A
authors.initials: OA
authors.lastname: Andreassen
authors.affiliation: a Department of Physical Medicine and Rehabilitation , Oslo University Hospital , Oslo , Norway.|h CHARM Research Centre for Habilitation and Rehabilitation Models & Services, Institute of Health and Society, University of Oslo , Oslo , Norway.
authors.forename: N
authors.initials: N
authors.lastname: Andelic
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging*; D001924:Brain Concussion / Q000000981:diagnostic imaging*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D015898:Tomography Scanners, X-Ray Computed; D055815:Young Adult
keywords: Mild brain injury; concussion; cortical thickness; intracranial injury; neuroimaging; radiology