title: Management of elderly patients suffering from cancer: Assessment of perceived burden and of quality of life of primary caregivers.
abstract: OBJECTIVE
  To evaluate the perceived burden and the quality of life (QoL) at 3 and 6months of the primary caregiver (PC) of patients aged 70 and over suffering from cancer and the predictors of QoL in this population.
  
  
  METHODS
  In this prospective observational study, 98 patients aged 70 and older with cancer and 96 PCs were included between 01/06/2014 and 18/03/2015. The Medical Outcomes Study 12-item Short Form Health Survey (SF-12) was used to assess the QoL of PCs and the Zarit Burden Interview (ZBI) was used to measure the perceived burden at 3 and 6months. The major determinants of QoL were identified using mixed linear models for the dimensions of the SF-12 that showed an average difference of at least 5 points between baseline and follow-up at 6months.
  
  
  RESULTS
  The QoL scores of PCs showed a decrease in the dimensions "role emotional" and "bodily pain" over 6months. In multivariate analysis, the main determinants of QoL for "role emotional" were the PC's age (p=0.005), a low perceived burden (p<0.0001) and a functionally independent patient (p=0.01), and for "bodily pain" was a low perceived burden (p<0.0001) and the non-use of hormone therapy during the treatment (p<0.0001).
  
  
  CONCLUSIONS
  The main determinants of the QoL of PCs concerned factors inherent to the PC (age and perceived burden) and patient (functional independence).
authors.affiliation: Department of Geriatrics and Internal Medicine, Hospital of Champmaillot, University Hospital, Dijon, France; Geriatric Oncology Coordination Unit in Burgundy, University Hospital, Dijon, France.
authors.forename: Victor
authors.initials: V
authors.lastname: Germain
authors.affiliation: Côte d'Or Breast and Gynaecological Cancer Registry, Centre George François Leclerc, 1 rue du Professeur Marion, BP 77980, Dijon Cedex, France; National Clinical Research Platform for Quality of Life in Oncology, France.
authors.forename: Tienhan Sandrine
authors.initials: TS
authors.lastname: Dabakuyo-Yonli
authors.affiliation: Department of Geriatrics and Internal Medicine, Hospital of Champmaillot, University Hospital, Dijon, France; Geriatric Oncology Coordination Unit in Burgundy, University Hospital, Dijon, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Marilier
authors.affiliation: Department of Geriatrics and Internal Medicine, Hospital of Champmaillot, University Hospital, Dijon, France; Geriatric Oncology Coordination Unit in Burgundy, University Hospital, Dijon, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Putot
authors.affiliation: Medical Oncology Department, Centre George François Leclerc, 1 rue du Professeur Marion, BP 77980, Dijon Cedex, France.
authors.forename: Leila
authors.initials: L
authors.lastname: Bengrine-Lefevre
authors.affiliation: Côte d'Or Breast and Gynaecological Cancer Registry, Centre George François Leclerc, 1 rue du Professeur Marion, BP 77980, Dijon Cedex, France; National Clinical Research Platform for Quality of Life in Oncology, France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Arveux
authors.affiliation: Department of Geriatric Rehabilitation, Hospital of Champmaillot, University Hospital, Dijon F-21079, France; UMR Inserm/U1093 Cognition, Action, Sensorimotor Plasticity, University of Burgundy, Dijon, France. Electronic address: patrick.manckoundia@chu-dijon.fr.
authors.forename: Patrick
authors.initials: P
authors.lastname: Manckoundia
authors.affiliation: Department of Geriatrics and Internal Medicine, Hospital of Champmaillot, University Hospital, Dijon, France; Geriatric Oncology Coordination Unit in Burgundy, University Hospital, Dijon, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Quipourt
mesh_terms: D000203:Activities of Daily Living; D000367:Age Factors; D000369:Aged, 80 and over; D017028:Caregivers / Q000523:psychology*; D017281:Cost of Illness; D018450:Disease Progression; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000628:therapy*; D011446:Prospective Studies; D011788:Quality of Life / Q000523:psychology*; D011795:Surveys and Questionnaires; D013997:Time Factors
keywords: Burden; Geriatric oncology consultation; Primary caregiver; Quality of life