title: Zero hospital admissions for infection after 577 transperineal prostate biopsies using single-dose cephazolin prophylaxis.
abstract: OBJECTIVE
  To determine the rate of hospital admissions for infection after transperineal biopsy of prostate (TPB) with single-dose cephazolin prophylaxis using a prospective database.
  
  
  METHODS
  Between April 2013 and February 2016, 577 patients undergoing TPB had 2 g of cephazolin given intravenously at induction of anaesthesia. Data collected from these patients included age, PSA, prostate volume, number of cores taken and post-operative complications.
  
  
  RESULTS
  No patients were readmitted to hospital with infection post-TPB. Seven patients developed acute urinary retention, and one patient developed clinical prostatitis that was treated with oral antibiotics in the community.
  
  
  CONCLUSIONS
  It is safe to use single-dose cephazolin only as antibiotic prophylaxis prior to TPB, negating the need for quinolones. This study supports Australia's current Therapeutic Guidelines recommendation for TPB prophylaxis and the existing evidence that sepsis post-TPB is a rare complication. Whether any antibiotic prophylaxis is needed at all for TPB is the subject of a future study.
authors.affiliation: Australian Urology Associates, Melbourne, VIC, Australia. lanapep@gmail.com.
authors.forename: Lana
authors.initials: L
authors.lastname: Pepdjonovic
authors.affiliation: Urology Unit, Department of Surgery, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.|Department of Urology, Alfred Health, Melbourne, VIC, Australia.
authors.forename: Guan Hee
authors.initials: GH
authors.lastname: Tan
authors.affiliation: Australian Urology Associates, Melbourne, VIC, Australia.
authors.forename: Sean
authors.initials: S
authors.lastname: Huang
authors.affiliation: Australian Urology Associates, Melbourne, VIC, Australia.
authors.forename: Sarah
authors.initials: S
authors.lastname: Mann
authors.affiliation: Australian Urology Associates, Melbourne, VIC, Australia.|Department of Surgery, Monash University, Melbourne, VIC, Australia.
authors.forename: Mark
authors.initials: M
authors.lastname: Frydenberg
authors.affiliation: Australian Urology Associates, Melbourne, VIC, Australia.
authors.forename: Daniel
authors.initials: D
authors.lastname: Moon
authors.affiliation: Australian Urology Associates, Melbourne, VIC, Australia.
authors.forename: Uri
authors.initials: U
authors.lastname: Hanegbi
authors.affiliation: Australian Urology Associates, Melbourne, VIC, Australia.
authors.forename: Adam
authors.initials: A
authors.lastname: Landau
authors.affiliation: Australian Urology Associates, Melbourne, VIC, Australia.
authors.forename: Ross
authors.initials: R
authors.lastname: Snow
authors.affiliation: Australian Urology Associates, Melbourne, VIC, Australia.|Department of Urology, Alfred Health, Melbourne, VIC, Australia.|Department of Surgery, Monash University, Melbourne, VIC, Australia.
authors.forename: Jeremy
authors.initials: J
authors.lastname: Grummet
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis / Q000379:methods; D062005:Biopsy, Large-Core Needle / Q000379:methods; D002437:Cefazolin / Q000627:therapeutic use*; D016208:Databases, Factual; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010359:Patient Readmission / Q000706:statistics & numerical data; D010502:Perineum; D011183:Postoperative Complications / Q000453:epidemiology*; D011467:Prostate / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000473:pathology*; D018805:Sepsis / Q000453:epidemiology*; D013530:Surgical Wound Infection / Q000453:epidemiology
chemical_list: D000900:Anti-Bacterial Agents; D002437:Cefazolin
keywords: Antibiotic prophylaxis; Cephazolin; Prostate; Transperineal biopsy