title: Termiglaucescin, a new polyhydroxy triterpene glucoside from Terminalia glaucescens with antioxidant and anti-inflammatory potential.
abstract: Termiglaucescin (1), a new triterpene glucoside, has been isolated from the ethyl acetate extract of the root bark of Terminalia glaucescens Planch. ex Benth, together with 11 known compounds, β-D-glucopyranosyl 2α,3β,6β-trihydroxy-23-galloylolean-12-en-28-oate (2), arjunglucoside I (3), sericoside (4), arjungenin (5), sericic acid (6), arjunetin (7), chebuloside II (8), 3,3',4-tri-O-methylelagic acid (9), 3,3'-di-O-methylelagic acid (10), β-sitosterol (11) and stigmasterol (12). Compounds 2, 3, 7, 8 and 9 are reported from the plant for the first time. The structures of the isolated compounds were characterized by spectroscopic data interpretations, especially 1D and 2D NMR. The triterpenic isolates showed potent antioxidant and anti-inflammatory activities.
authors.affiliation: Department of Chemistry, Higher Teachers Training College, University of Maroua, P.O. Box 55, Maroua, Cameroon.
authors.forename: Amadou
authors.initials: A
authors.lastname: Dawé
authors.affiliation: Department of Chemistry, Faculty of Science, University of Ngaoundéré, P.O. Box 454, Ngaoundéré, Cameroon.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Talom
authors.affiliation: Department of Chemistry, Higher Teachers' Training College, University of Yaoundé I, P.O. Box 47, Yaoundé, Cameroon.
authors.forename: Gilbert Deccaux Wabo Fotso
authors.initials: GDWF
authors.lastname: Kapche
authors.affiliation: Pharmaceutical Research Center, PCSIR Laboratories Karachi Complex, Karachi 75280, Pakistan.
authors.forename: Kauser
authors.initials: K
authors.lastname: Siddiqui
authors.affiliation: Department of Chemistry, Higher Teachers Training College, University of Maroua, P.O. Box 55, Maroua, Cameroon.
authors.forename: Fawai
authors.initials: F
authors.lastname: Yakai
authors.affiliation: Department of Chemistry, Faculty of Science, University of Ngaoundéré, P.O. Box 454, Ngaoundéré, Cameroon.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Talla
authors.affiliation: International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
authors.forename: Muhammad Ali
authors.initials: MA
authors.lastname: Shaiq
authors.affiliation: Pharmaceutical Research Center, PCSIR Laboratories Karachi Complex, Karachi 75280, Pakistan.
authors.forename: Iqbal
authors.initials: I
authors.lastname: Lubna
authors.affiliation: Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon.
authors.forename: Bonabenture Tchaleu
authors.initials: BT
authors.lastname: Ngadjui
mesh_terms: D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000737:chemistry; D004912:Erythrocytes / Q000187:drug effects; D005960:Glucosides / Q000302:isolation & purification / Q000494:pharmacology*; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D016859:Lipoxygenase Inhibitors / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D008517:Phytotherapy; D010851:Picrates / Q000737:chemistry; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal; D011489:Protein Denaturation; D012503:Saponins / Q000302:isolation & purification / Q000494:pharmacology*; D012710:Serum Albumin, Bovine / Q000737:chemistry; D013329:Structure-Activity Relationship; D029766:Terminalia / Q000737:chemistry*; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D001713:Biphenyl Compounds; D005960:Glucosides; D016859:Lipoxygenase Inhibitors; D010851:Picrates; D010936:Plant Extracts; D012503:Saponins; D014315:Triterpenes; C000621790:termiglaucescin; D012710:Serum Albumin, Bovine; C004931:1,1-diphenyl-2-picrylhydrazyl
keywords: Combretaceae; Terminalia glaucescens; anti-inflammatory; antioxidant; triterpene glucosides