title: Risk for Hip Fracture due to Alpha Blocker Treatment in Korean Women: National Health Insurance Database Study.
abstract: OBJECTIVE
  The aim of this study is to evaluate the risk for hip fracture associated with adverse drug reactions caused by α1-adrenergic (alpha) blockers to treat female voiding dysfunction.
  
  
  METHODS
  Information from the Health Insurance Review and Assessment Service database from January 1, 2008 to December 31, 2012 was used. Hip fracture women patients who received a prescription for an alpha blocker due to voiding dysfunction were the cases. A 30-day hazard period after administration of an alpha blocker was set. The 30-day control period was defined as 360 days before administration. The standardized incidence ratio and hazard ratio for the risk of hip bone fracture as related to alpha blocker use were analyzed.
  
  
  RESULTS
  The study cohort included 287 383 subjects having a mean age of 65.1 ± 9.7 years in the study cohort. A total of 170 and 79 hip fracture cases were diagnosed in the hazard period and control period, respectively. The incidence of newly diagnosed hip fractures per 100 000 person-years was 763.4 in the hazard period and 348.5 in the control period. The hazard ratio for hip fracture after use of an alpha blocker was 2.19 (95% confidence interval, 1.74-2.77).
  
  
  CONCLUSIONS
  Alpha blockers to treat voiding dysfunction may have association with the risk for hip fracture in elderly women.
authors.affiliation: Health Insurance Review and Assessment Service, Seoul, Korea.
authors.forename: Gi H
authors.initials: GH
authors.lastname: Seo
authors.affiliation: Institute for Clinical Molecular Biology Research, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, Seoul, Korea.
authors.forename: Sung R
authors.initials: SR
authors.lastname: Shim
authors.affiliation: Department of Orthopaedics, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, Seoul, Korea.
authors.forename: Hwan W
authors.initials: HW
authors.lastname: Lee
authors.affiliation: Department of Orthopaedics, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, Seoul, Korea.
authors.forename: Jin H
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Department of Orthopaedics, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, Seoul, Korea.
authors.forename: Dong-Il
authors.initials: DI
authors.lastname: Chun
authors.affiliation: Department of Preventive Medicine, Korea University College of Medicine, Seoul, Korea.
authors.forename: Hyun J
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Department of Urology, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, Seoul, Korea.
authors.forename: Hyun Y
authors.initials: HY
authors.lastname: Lee
authors.affiliation: Department of Urology, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, Seoul, Korea.
authors.forename: Jae H
authors.initials: JH
authors.lastname: Kim
mesh_terms: D000058:Accidental Falls; D058668:Adrenergic alpha-1 Receptor Antagonists / Q000009:adverse effects*; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006620:Hip Fractures / Q000139:chemically induced* / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D059411:Lower Urinary Tract Symptoms / Q000188:drug therapy*; D008875:Middle Aged; D056910:Republic of Korea / Q000453:epidemiology; D012307:Risk Factors
chemical_list: D058668:Adrenergic alpha-1 Receptor Antagonists
keywords: alpha blockers; bladder dysfunction; females; hip bone fractures; lower urinary tract symptoms