title: Descriptive Epidemiology of Orofacial Clefts in Ethiopia.
abstract: BACKGROUND
  The prevalence of birth defects including orofacial clefts (OFC) in Ethiopia is not known and there is no established birth defects registration system.
  
  
  OBJECTIVE
  To investigate the prevalence and incidence of OFC in Ethiopia.
  
  
  METHODS
  Retrospective hospital-based descriptive study.
  
  
  METHODS
  The authors obtained data from the Smile Train database on Ethiopian patients with OFC who underwent surgical treatment from June 2007 to December 2013 at 31 hospitals distributed throughout the country. Data related to live births in Ethiopia during the mentioned period were obtained from the Federal Ministry of Health database for estimates of the incidence and prevalence rates.
  
  
  RESULTS
  The total number of life births during the study period was 18,811,316. During this same period, 18,073 cleft patients approximately ranging from 1 to 75 years old were examined and treated at the hospitals mentioned earlier. The incidence rate estimated from the total number of affected children during the study period (N = 8232) is 0.44/1000 live births. The prevalence rate is 0.20/1000 and this was estimated using the number of total population in 2013 (N = 88,703,914). There is a significant difference in frequency between bilateral clefts of the lip and/or palate (CLP) (26.9%) versus unilateral CLP (73.1%) (P < 0.0001). There is also a significant difference in frequency between bilateral cleft lips only (15.4%) versus unilateral cleft lip only (84.6%), P < 0001.
  
  
  CONCLUSIONS
  It is obvious that the findings in this study cannot be representative of the true picture but provides a previously unavailable national estimate of incidence and prevalence of OFC in Ethiopia. It can also be used as comparison for future community-based studies.
authors.affiliation: *School of Public Health, College of Health Sciences, Addis Ababa University †Plastic and Reconstructive Surgery Unit, Yekatit 12 Hospital Medical College ‡Department of Surgery, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia §Department of Oral Pathology, Radiology and Medicine, College of Dentistry, University of Iowa ||Division of Biostatistics and Research Design, College of Dentistry, University of Iowa, Iowa City, IA ¶Neonatology Unit, Yekatit 12 Hospital Medical College, Addis Ababa, Ethiopia #Plastic and Reconstructive Surgery Department, Haukeland University Hospital, Bergen, Norway **Department of Orthodontics, University of Dundee, Scotland, UK.
authors.forename: Mekonen
authors.initials: M
authors.lastname: Eshete
authors.forename: Azeez
authors.initials: A
authors.lastname: Butali
authors.forename: Wakgari
authors.initials: W
authors.lastname: Deressa
authors.forename: Keyla
authors.initials: K
authors.lastname: Pagan-Rivera
authors.forename: Taye
authors.initials: T
authors.lastname: Hailu
authors.forename: Fikre
authors.initials: F
authors.lastname: Abate
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Mohammed
authors.forename: Yohannes
authors.initials: Y
authors.lastname: Demissie
authors.forename: Abiye
authors.initials: A
authors.lastname: Hailu
authors.forename: Deborah V
authors.initials: DV
authors.lastname: Dawson
authors.forename: Milliard
authors.initials: M
authors.lastname: Deribew
authors.forename: Mulualem
authors.initials: M
authors.lastname: Gessese
authors.forename: Paul E
authors.initials: PE
authors.lastname: Gravem
authors.forename: Peter
authors.initials: P
authors.lastname: Mossey
mesh_terms: D000328:Adult; D000368:Aged; D002648:Child; D002971:Cleft Lip / Q000175:diagnosis / Q000453:epidemiology; D002972:Cleft Palate / Q000175:diagnosis / Q000453:epidemiology; D005002:Ethiopia / Q000453:epidemiology; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D008297:Male; D015995:Prevalence; D012189:Retrospective Studies