title: Design of pectin-sodium alginate based films for potential healthcare application: Study of chemico-physical interactions between the components of films and assessment of their antimicrobial activity.
abstract: In this study, pectin based films including different amounts of sodium alginate were prepared by casting method. All the films, with and without polyglycerol as plasticizer, were crosslinked with zinc ions in order to extend their potential functionality. The development of junction points, occurring during the crosslinking process with zinc ions, induced the increasing of free volume with following changing in chemico-physical properties of films. The inclusion of alginate in pectin based formulations improved the strength of zinc ions crosslinking network, whereas the addition of polyglycerol significantly improved mechanical performance. Finally, zinc-crosslinked films evidenced antimicrobial activity against the most common exploited pathogens: Staphylococcus Aureus, Escherichia Coli and Candida Albicans. These results suggest that zinc-crosslinked based films can be exploitable as novel bio-active biomaterials for protection and disinfection of medical devices.
authors.affiliation: University of Belgrade, Vinča Institute of Nuclear Sciences, Mike Petrovića-Alasa 12-14, Belgrade, Serbia. Electronic address: anesic@vin.bg.ac.rs.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Nešić
authors.affiliation: University of Belgrade, Vinča Institute of Nuclear Sciences, Mike Petrovića-Alasa 12-14, Belgrade, Serbia.
authors.forename: Antonije
authors.initials: A
authors.lastname: Onjia
authors.affiliation: University of Belgrade, Faculty of Technology and Metallurgy, Karnegijeva 4, Belgrade, Serbia.
authors.forename: Sladjana
authors.initials: S
authors.lastname: Davidović
authors.affiliation: University of Belgrade, Faculty of Technology and Metallurgy, Karnegijeva 4, Belgrade, Serbia.
authors.forename: Suzana
authors.initials: S
authors.lastname: Dimitrijević
authors.affiliation: Institute for Polymers, Composites and Biomaterials, Via Campi Flegrei 34, Pozzuoli, 80078, Naples, Italy.
authors.forename: Maria Emanuela
authors.initials: ME
authors.lastname: Errico
authors.affiliation: Institute for Polymers, Composites and Biomaterials, Via Campi Flegrei 34, Pozzuoli, 80078, Naples, Italy. Electronic address: santagata@ipcb.cnr.it.
authors.forename: Gabriella
authors.initials: G
authors.lastname: Santagata
authors.affiliation: Institute for Polymers, Composites and Biomaterials, Via Campi Flegrei 34, Pozzuoli, 80078, Naples, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Malinconico
mesh_terms: D000464:Alginates / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000737:chemistry*; D002176:Candida albicans; D004926:Escherichia coli; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D010368:Pectins / Q000737:chemistry*; D013211:Staphylococcus aureus
chemical_list: D000464:Alginates; D000890:Anti-Infective Agents; D006603:Hexuronic Acids; D010368:Pectins; D020723:Glucuronic Acid
keywords: Alginate; Antimicrobial films; Pectin; Pectin from Citrus (PubChemCID: 441476); Polyglycerol (PubChemCID: 92007); Sodium Alginate (PubChemCID: 5102882); Water (PubChem CID: 952); Zinc Chloride (PubChemCID: 3007855); Zinc crosslinking