title: A fresh look at IBS-opportunities for systems medicine approaches.
abstract: NeuroGUT is a EU-funded initial training network (ITN) of 14 research projects in neurogastroenterology that have employed an equal number of early-stage researchers. Neurogut trainees have-among other activities-attended an international conference on irritable bowel syndrome (IBS) in Bologna in 2016 and were asked to critically review and evaluate the current knowledge on IBS for their respective research activities, and to state what they were missing. Most appreciated were the topics brain imaging of gut activity, the role of the gut microbiota, the pharmacology of gut functions, the IBS-IBD interrelation, the new Rome IV criteria, the role of gas, and the placebo response in functional disorders. Missed were more detailed coverage of high-resolution manometry, functional brain imaging, advanced "systems medicine" approaches and bioinformatics technology, better sub-classification of IBS patients, and the development of disease biomarkers, extended at the molecular (genetic/epigenetic, proteonomic) level. They summarize that despite excellent specialized research, there is a gap open that should be filled with systems medicine. For this, it would be necessary that medical research learns even more from the data sciences and other basic disciplines, for example, information technology and system biology, and also welcomes a change in paradigm that enhances open sharing of data, information, and resources.
authors.affiliation: Queen Mary and Westfield College University of London, London, UK.
authors.forename: A
authors.initials: A
authors.lastname: Albusoda
authors.affiliation: Technische Universität München, Munich, Germany.
authors.forename: N
authors.initials: N
authors.lastname: Barki
authors.affiliation: Academisch Medisch Centrum bij de Universiteit, Amsterdam, The Netherlands.
authors.forename: T
authors.initials: T
authors.lastname: Herregods
authors.affiliation: Institut National de la Recherche Agronomique, Toulouse, France.
authors.forename: J B J
authors.initials: JB
authors.lastname: Kamphuis
authors.affiliation: Alma Mater Studiorum Università di Bologna, Bologna, Italy.
authors.forename: T B
authors.initials: TB
authors.lastname: Karunaratne
authors.affiliation: Technische Universität München, Munich, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Lazarou
authors.affiliation: Eberhard Karls Universität Tübingen, Tübingen, Germany.
authors.forename: I
authors.initials: I
authors.lastname: Lee
authors.affiliation: Symbio Pharm GmbH, Herborn, Germany.
authors.forename: N
authors.initials: N
authors.lastname: Mazurak
authors.affiliation: Katholieke Universiteit Leuven, Leuven, Belgium.
authors.forename: E
authors.initials: E
authors.lastname: Perna
authors.affiliation: Göteborgs Universitet, Gothenburg, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Polster
authors.affiliation: Fundacio Hospital Universitari Vall d'Hebron, Institut de Recerca, Barcelona, Spain.
authors.forename: T
authors.initials: T
authors.lastname: Pribic
authors.affiliation: University of Sheffield, Sheffield, UK.
authors.forename: F
authors.initials: F
authors.lastname: Uhlig
authors.affiliation: Eberhard Karls Universität Tübingen, Tübingen, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Wang
authors.affiliation: Eberhard Karls Universität Tübingen, Tübingen, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Enck
mesh_terms: D035843:Biomedical Research / Q000193:education* / Q000639:trends; D004500:Education, Graduate / Q000639:trends; D005062:European Union; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000453:epidemiology* / Q000628:therapy*; D013597:Systems Analysis
keywords: functional bowel disorders; irritable bowel syndrome