title: Transcranial Alternating Current Stimulation: A Potential Risk for Genetic Generalized Epilepsy Patients (Study Case).
abstract: Transcranial alternating current stimulation (tACS) is a re-emergent neuromodulation technique that consists in the external application of oscillating electrical currents that induces changes in cortical excitability. We present the case of a 16-year-old female with pharmaco-resistant juvenile myoclonic epilepsy to 3 antiepileptic's drugs characterized by 4 myoclonic and 20 absence seizures monthly. She received tACS at 1 mA at 3 Hz pulse train during 60 min over Fp1-Fp2 (10-20 EEG international system position) during 4 consecutive days using an Endeavor™ IOM Systems device®(Natus Medical Incorporated, Middleton, WI, USA). At the 1-month follow-up, she reported a 75% increase in seizures frequency (only myoclonic and tonic-clonic events) and developed a 24-h myoclonic status epilepticus that resolved with oral clonazepam and intravenous valproate. At the 2-month follow-up, the patient reported a 15-day seizure-free period.
authors.affiliation: Department of Clinical Research, National Institute of Neurology and Neurosurgery , Mexico City , Mexico.
authors.forename: Daniel
authors.initials: D
authors.lastname: San-Juan
authors.affiliation: Department of Clinical Research, National Institute of Neurology and Neurosurgery, Mexico City, Mexico; Department of Basic Sciences and Engineering, Autonomous Metropolitan University Campus Iztapalapa, Mexico City, Mexico.
authors.forename: Carlos Ignacio
authors.initials: CI
authors.lastname: Sarmiento
authors.affiliation: Department of Clinical Research, National Institute of Neurology and Neurosurgery, Mexico City, Mexico; Superior School of Medicine, National Polytechnic Institute, Mexico City, Mexico.
authors.forename: Axel
authors.initials: A
authors.lastname: Hernandez-Ruiz
authors.affiliation: Medicine Academic Unit, Autonomous University of Nayarit , Tepic , Mexico.
authors.forename: Ernesto
authors.initials: E
authors.lastname: Elizondo-Zepeda
authors.affiliation: Department of Medicine and Nutrition, University of Guanajuato , León , Mexico.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Santos-Vázquez
authors.affiliation: Department of Clinical Sciences, University of Monterrey , San Pedro Garza-García , Mexico.
authors.forename: Gerardo
authors.initials: G
authors.lastname: Reyes-Acevedo
authors.affiliation: Medicine Academic Unit, Autonomous University of Nayarit , Tepic , Mexico.
authors.forename: Héctor
authors.initials: H
authors.lastname: Zúñiga-Gazcón
authors.affiliation: Department of Clinical Research, National Institute of Neurology and Neurosurgery, Mexico City, Mexico; Institute of Neuropsychology and Neuropsychopedagogy, Mexico City, Mexico.
authors.forename: Carol Marina
authors.initials: CM
authors.lastname: Zamora-Jarquín
keywords: juvenile myoclonic epilepsy; neuromodulation; transcranial alternating current stimulation