title: Exosomes and breast cancer: a comprehensive review of novel therapeutic strategies from diagnosis to treatment.
abstract: Exosomes are nanosized vesicles, released by various cells, which have essential roles in intercellular communication locally and systemically through transporting their contents such as proteins and lipids as well as RNA. It was clear that the element of contents in exosomes reassembled with the emerging of cancers. Over the past decade, researchers paid more attention to the role of exosomes in breast cancer. The purpose of this review was to discuss the details of the biological characteristics of exosomes in breast cancer. The discussion would focus on the role of exosomes in breast cancer development, progression, metastasis and drug resistance, as well as related therapeutic and diagnostic strategies.
authors.affiliation: Medical Molecular Diagnostics Key Laboratory of Guangdong, and Department of Biochemistry and Molecular Biology and Department of Clinical Biochemistry in Guangdong Medical University, Dongguan, Guangdong, People's Republic of China.
authors.forename: C-Y
authors.initials: CY
authors.lastname: Wu
authors.affiliation: Medical Molecular Diagnostics Key Laboratory of Guangdong, and Department of Biochemistry and Molecular Biology and Department of Clinical Biochemistry in Guangdong Medical University, Dongguan, Guangdong, People's Republic of China.
authors.forename: S-L
authors.initials: SL
authors.lastname: Du
authors.affiliation: Medical Molecular Diagnostics Key Laboratory of Guangdong, and Department of Biochemistry and Molecular Biology and Department of Clinical Biochemistry in Guangdong Medical University, Dongguan, Guangdong, People's Republic of China.
authors.forename: J
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Medical Molecular Diagnostics Key Laboratory of Guangdong, and Department of Biochemistry and Molecular Biology and Department of Clinical Biochemistry in Guangdong Medical University, Dongguan, Guangdong, People's Republic of China.
authors.forename: A-L
authors.initials: AL
authors.lastname: Liang
authors.affiliation: Medical Molecular Diagnostics Key Laboratory of Guangdong, and Department of Biochemistry and Molecular Biology and Department of Clinical Biochemistry in Guangdong Medical University, Dongguan, Guangdong, People's Republic of China.
authors.forename: Y-J
authors.initials: YJ
authors.lastname: Liu
mesh_terms: D000818:Animals; D001692:Biological Transport; D015415:Biomarkers; D001943:Breast Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000628:therapy; D002450:Cell Communication; D002471:Cell Transformation, Neoplastic / Q000378:metabolism; D018450:Disease Progression; D016503:Drug Delivery Systems; D019008:Drug Resistance, Neoplasm; D055354:Exosomes / Q000378:metabolism*; D005260:Female; D006801:Humans; D056747:Immunomodulation; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis
chemical_list: D015415:Biomarkers