title: Signaling mechanisms implicated in cranial sutures pathophysiology: Craniosynostosis.
abstract: Normal extension and skull expansion is a synchronized process that prevails along the osteogenic intersections of the cranial sutures. Cranial sutures operate as bone growth sites allowing swift bone generation at the edges of the bone fronts while they remain patent. Premature fusion of one or more cranial sutures can trigger craniosynostosis, a birth defect characterized by dramatic manifestations in appearance and functional impairment. Up until today, surgical correction is the only restorative measure for craniosynostosis associated with considerable mortality. Clinical studies have identified several genes implicated in the pathogenesis of craniosynostosis syndromes with useful insights into the underlying molecular signaling events that determine suture fate. In this review, we exploit the intracellular signal transduction pathways implicated in suture pathobiology, in an attempt to identify key signaling molecules for therapeutic targeting.
authors.affiliation: Department of Biological Chemistry - Cellular and Molecular Biomechanics Unit, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
authors.forename: Maria A
authors.initials: MA
authors.lastname: Katsianou
authors.affiliation: Department of Biological Chemistry - Cellular and Molecular Biomechanics Unit, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
authors.forename: Christos
authors.initials: C
authors.lastname: Adamopoulos
authors.affiliation: Department of Orthodontics, Dental School, National and Kapodistrian University of Athens, 11527, Athens, Greece.
authors.forename: Heleni
authors.initials: H
authors.lastname: Vastardis
authors.affiliation: Department of Biological Chemistry - Cellular and Molecular Biomechanics Unit, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
authors.forename: Efthimia K
authors.initials: EK
authors.lastname: Basdra
keywords: Craniosynostosis; Craniosynostosis therapies; Mechanical stimuli; Molecular signaling; Polycystins; Sutures