title: The 12 Gastrointestinal Pathogens Spectrum of Acute Infectious Diarrhea in a Sentinel Hospital, Shenzhen, China.
abstract: Acute infectious gastroenteritis is one of the most common diseases among all ages, particularly in developing countries. The pathogen spectrum may differ among different regions and seasons. To investigate the etiology of acute diarrhea in Shenzhen, a prospective study was conducted from August 2014 to September 2015. Stools from 412 patients with diarrhea (286 of whom were adults) including the general epidemiological information of the patients were collected. The 19 pathogens were detected by conventional culture method or multiplex PCR assay, which included five viruses (rotavirus, adenovirus, sapovirus, norovirus, and astrovirus), 11 bacterial pathogens (Salmonella, Campylobacter jejuni, Shigella, Listeria monocytogenes, Vibrio parahaemolyticus, Vibrio cholera, Enterohemorrhagic (EHEC), enteropathogenic (EPEC), enteroinvasive (EIEC), enterotoxigenic (ETEC); and enteroaggregativeEscherichia coli(EAEC)) and three parasites (Entamoeba histolytica, Giardia lamblia, andCryptosporidium parvum). A potential pathogen and coinfection was found in 41.5 and 7.0% of cases, respectively. The bacterial infection was the dominant cause of diarrhea (32.3%), and the three most frequently identified organisms wereSalmonella(12.1%), ETEC (8.0%), andCampylobacter jejuni(4.9%).Salmonellaenteritidis was the leading serotype ofSalmonellasp. Norovirus (8.3%) and sapovirus (2.2%) were the most common viral pathogens, followed by adenovirus (1.5%) and rotavirus (1.2%). No EHEC,L. monocytogenes, V. cholera, Shigella, and parasites were found. The single most important causes of diarrhea wereSalmonellaspp. andCampylobacter jejuni, which points toward the need for testing and surveillance for these pathogens in this region.
authors.affiliation: Futian District Center for Disease Control and Prevention Shenzhen, China.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Shen
authors.affiliation: Futian District Center for Disease Control and Prevention Shenzhen, China.
authors.forename: Jinjin
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Shenzhen Major Infectious Disease Control Key Laboratory, Shenzhen Center for Disease Control and Prevention Shenzhen, China.
authors.forename: Yinghui
authors.initials: Y
authors.lastname: Li
authors.affiliation: Futian District Center for Disease Control and Prevention Shenzhen, China.
authors.forename: Sirou
authors.initials: S
authors.lastname: Xie
authors.affiliation: Shenzhen Major Infectious Disease Control Key Laboratory, Shenzhen Center for Disease Control and Prevention Shenzhen, China.
authors.forename: Yixiang
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Peking University Shenzhen Hospital Shenzhen, China.
authors.forename: Yanjie
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Peking University Shenzhen Hospital Shenzhen, China.
authors.forename: Yuhui
authors.initials: Y
authors.lastname: Ye
authors.affiliation: Peking University Shenzhen Hospital Shenzhen, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Yang
authors.affiliation: Futian District Center for Disease Control and Prevention Shenzhen, China.
authors.forename: Haolian
authors.initials: H
authors.lastname: Mo
authors.affiliation: Futian District Center for Disease Control and Prevention Shenzhen, China.
authors.forename: Chaoman
authors.initials: C
authors.lastname: Situ
authors.affiliation: Shenzhen Major Infectious Disease Control Key Laboratory, Shenzhen Center for Disease Control and Prevention Shenzhen, China.
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Hu
keywords: Shenzhen; acute infectious diarrhea; gastrointestinal pathogen; sentinel hospital; spectrum