title: The Hair Growth-Promoting Effect ofRumex japonicusHoutt. Extract.
abstract: Rumex japonicusHoutt. is traditionally used as a medicinal plant to treat patients suffering from skin disease in Korea. However, the beneficial effect ofRumex japonicusHoutt. on hair growth has not been thoroughly examined. Therefore, the present study aims to investigate the hair growth-promoting effect ofRumex japonicus(RJ) Houtt. root extract using human dermal papilla cells (DPCs), HaCaT cells, and C57BL/6 mice model. RJ induced antiapoptotic and proliferative effects on DPCs and HaCaT cells by increasing Bcl-2/Bax ratio and activating cellular proliferation-related proteins, ERK and Akt. RJ also increasedβ-catenin via the inhibition of GSK-3β. In C57BL/6 mice model, RJ promoted the anagen induction and maintained its period. Immunohistochemistry analysis demonstrated that RJ upregulated Ki-67 andβ-catenin expressions, suggesting that the hair growth effect of RJ may be mediated through the reinforcement of hair cell proliferation. These results provided important insights for the possible mechanism of action of RJ and its potential as therapeutic agent to promote hair growth.
authors.affiliation: College of Veterinary Medicine, Gyeongsang National University, Jinju 52828, Republic of Korea; Institute of Animal Medicine, Gyeongsang National University, Jinju 52828, Republic of Korea.
authors.forename: Hyunkyoung
authors.initials: H
authors.lastname: Lee
authors.affiliation: Gyeongnam Department of Environment Toxicology and Chemistry, Toxicity Screening Research Center, Korea Institute of Toxicology, Jinju 52834, Republic of Korea.
authors.forename: Na-Hyun
authors.initials: NH
authors.lastname: Kim
authors.affiliation: College of Veterinary Medicine, Gyeongsang National University, Jinju 52828, Republic of Korea.
authors.forename: Hyeryeon
authors.initials: H
authors.lastname: Yang
authors.affiliation: College of Veterinary Medicine, Gyeongsang National University, Jinju 52828, Republic of Korea; Institutes of Agriculture and Life Science, Gyeongsang National University, Jinju 52828, Republic of Korea.
authors.forename: Seong Kyeong
authors.initials: SK
authors.lastname: Bae
authors.affiliation: College of Veterinary Medicine, Gyeongsang National University, Jinju 52828, Republic of Korea.
authors.forename: Yunwi
authors.initials: Y
authors.lastname: Heo
authors.affiliation: College of Veterinary Medicine, Gyeongsang National University, Jinju 52828, Republic of Korea.
authors.forename: Indu
authors.initials: I
authors.lastname: Choudhary
authors.affiliation: College of Veterinary Medicine, Gyeongsang National University, Jinju 52828, Republic of Korea.
authors.forename: Young Chul
authors.initials: YC
authors.lastname: Kwon
authors.affiliation: College of Veterinary Medicine, Gyeongsang National University, Jinju 52828, Republic of Korea.
authors.forename: Jae Kuk
authors.initials: JK
authors.lastname: Byun
authors.affiliation: College of Veterinary Medicine, Gyeongsang National University, Jinju 52828, Republic of Korea.
authors.forename: Hyeong Jun
authors.initials: HJ
authors.lastname: Yim
authors.affiliation: Biobeauty Korea Co., Ltd., Kyungsung University Business Incubator, Busan 48434, Republic of Korea.
authors.forename: Byung Seung
authors.initials: BS
authors.lastname: Noh
authors.affiliation: Gyeongnam Department of Environment Toxicology and Chemistry, Toxicity Screening Research Center, Korea Institute of Toxicology, Jinju 52834, Republic of Korea.
authors.forename: Jeong-Doo
authors.initials: JD
authors.lastname: Heo
authors.affiliation: College of Veterinary Medicine, Gyeongsang National University, Jinju 52828, Republic of Korea; Institute of Animal Medicine, Gyeongsang National University, Jinju 52828, Republic of Korea.
authors.forename: Euikyung
authors.initials: E
authors.lastname: Kim
authors.affiliation: College of Veterinary Medicine, Gyeongsang National University, Jinju 52828, Republic of Korea; Institute of Animal Medicine, Gyeongsang National University, Jinju 52828, Republic of Korea.
authors.forename: Changkeun
authors.identifier: 0000-0002-5114-5096
authors.initials: C
authors.lastname: Kang