title: Traditional uses, phytochemistry and pharmacology of wild banana (Musa acuminata Colla): A review.
abstract: BACKGROUND
  Musa acuminata, the wild species of banana is a plant of the tropical and subtropical regions. Over the past few decades, the health benefits of M. acuminata have received much attention. All parts of the plant including fruits, peel, pseudostem, corm, flowers, leaves, sap and roots have found their use in the treatment of many diseases in traditional medicine. Literature review have indicated use of M. acuminata in the treatment of various diseases such as fever, cough, bronchitis, dysentery, allergic infections, sexually transmitted infections, and some of the non-communicable diseases. The reported pharmacological activities of M. acuminata include antioxidant, antidiabetic, immunomodulatory, hypolipidemic, anticancer, and antimicrobial especially anti-HIV activity. This review presents information on the phytochemicals and pharmacological studies to validate the traditional use of different parts of M. acuminata in various diseases and ailments. A comprehensive assessment of the biological activities of M. acuminata extracts is included and possible mechanisms and phytochemicals involved have also been correlated to provide effective intervention strategies for preventing or managing diseases.
  
  
  METHODS
  A literature search was performed on M. acuminata using ethnobotanical textbooks, published articles in peer-reviewed journals, local magazines, unpublished materials, and scientific databases such as Pubmed, Scopus, Web of Science, ScienceDirect, and Google Scholar. The Plant List, Promusa, Musalit, the Integrated Taxonomic Information System (ITIS) databases were used to validate the scientific names and also provide information on the subspecies and cultivars of M. acuminata.
  
  
  CONCLUSIONS
  The edible part of M. acuminata provides energy, vitamins and minerals. All other parts of the plant have been used in the treatment of many diseases in traditional medicine. The rich diversity of phytochemicals present in them probably contributes to their beneficial effects, and validates the role of M. acuminata plant parts used by various tribes and ethnic groups across the geographical areas of the world.
  
  
  CONCLUSIONS
  This review presents information on phytochemicals and pharmacological activities of M. acuminata plant parts. Pharmacological studies support the traditional uses of the plant, and probably validate the uses of M. acuminata by the indigenous people to treat and heal many infections and diseases. Some studies on animal models have been carried out, which also provide evidence of efficacy of the M. acuminata plant as a therapeutic agent. These observations suggest that M. acuminata plant parts possesses pluripharmacological properties, and can be used in designing potent therapeutic agents. However, individual bioactive constituent(s) from different parts of this plant need further investigations to confirm various pharmacological claims, and to explore the potential of M. acuminata in the development of drugs and use in functional foods.
authors.affiliation: Fruit and Vegetable Technology Department, CSIR-Central Food Technological Research Institute, Mysore 570020, India; Academy of Scientific and Innovative Research (AcSIR), New Delhi 110001, India.
authors.forename: Nimisha Sarah
authors.initials: NS
authors.lastname: Mathew
authors.affiliation: Fruit and Vegetable Technology Department, CSIR-Central Food Technological Research Institute, Mysore 570020, India; Academy of Scientific and Innovative Research (AcSIR), New Delhi 110001, India. Electronic address: psnegi@cftri.res.in.
authors.forename: Pradeep Singh
authors.initials: PS
authors.lastname: Negi
mesh_terms: D000818:Animals; D006801:Humans; D008519:Medicine, Traditional; D028521:Musa; D064209:Phytochemicals / Q000032:analysis; D008517:Phytotherapy; D028321:Plant Preparations / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity
chemical_list: D064209:Phytochemicals; D028321:Plant Preparations
keywords: Anigorufone (PubChem CID: 636472); Antimicrobial; Antioxidant; Apigenin (PubChem CID 5280443); Dopamine (PubChem CID: 681); Episesamin (PubChem CID 1004374); Ethnomedicine; Flavonoids; Methoxyanigorufone (PubChem CID: 10085389); Musa acuminata; Naproxen (PubChem CID: 156391); Phenylphenalenones (PubChem CID: 636472); Phytochemistry; Pyranone (PubChem CID:119838); Sesamin (PubChem CID: 72307); β- Sitosterol (PubChem CID: 222284)