title: Associations ofIL-10genetic polymorphisms with the risk of urologic cancer: a meta-analysis based on 18,415 subjects.
abstract: BACKGROUND
  Interleukin-10 (IL-10) is a powerful modulator of anti-tumor immune responses. TheIL-10promoter region polymorphisms are known to regulate IL-10 production, and thus are thought to be implicated in tumorigenesis. Recently, the roles of these polymorphisms in urologic cancer have been extensively studied, with conflicting results. Therefore, we conducted the present meta-analysis to better elucidate the correlations betweenIL-10polymorphisms and urologic cancer risk.
  
  
  METHODS
  Eligible articles were searched in PubMed, Medline, Embase, Scopus and CNKI up to May 2016. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to detect any potential associations betweenIL-10polymorphisms and the risk of urologic cancer.
  
  
  RESULTS
  A total of 22 case-control studies including 8572 patients and 9843 controls were analyzed. The overall meta-analysis results showed thatIL-10-592C>A polymorphism was significantly associated with urologic cancer in CA versus AA (P= 0.04, OR 0.87, 95% CI 0.76-0.99) and AA versus CC+CA (P= 0.03, OR 1.15, 95% CI 1.02-1.31). Subgroup analyses by cancer types suggested there were significant associations between all the three investigatedIL-10polymorphisms and bladder cancer. However, subgroup analyses by ethnicity only detected a weak association betweenIL-10-819C>T and Asian population.
  
  
  CONCLUSIONS
  Our findings suggests thatIL-10-592C>A polymorphism may implicate with urologic cancer risk. Besides, promoter region polymorphisms ofIL-10may serve as potential biological markers, especially for bladder cancer. Furthermore,IL-10-819C>T polymorphism may contribute to urologic cancer susceptibility in Asians while all the three studied variants ofIL-10did not relate to Caucasian urologic cancer predisposition.
authors.affiliation: Division of Reproductive Medical Center, West China Second University Hospital, Sichuan University, Chengdu, Sichuan China ; Key Laboratory of Birth Defects and Related Diseases of Women and Children, West China Second University Hospital of Sichuan University, Chengdu, Sichuan China.
authors.forename: Xiaohan
authors.initials: X
authors.lastname: Shi
authors.affiliation: Department of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan China.
authors.forename: Xiaochuan
authors.initials: X
authors.lastname: Xie
authors.affiliation: West China School of Public Health, Sichuan University, Chengdu, Sichuan China.
authors.forename: Xiaoshuang
authors.initials: X
authors.lastname: Xun
authors.affiliation: Division of Reproductive Medical Center, West China Second University Hospital, Sichuan University, Chengdu, Sichuan China ; Key Laboratory of Birth Defects and Related Diseases of Women and Children, West China Second University Hospital of Sichuan University, Chengdu, Sichuan China.
authors.forename: Yingxian
authors.initials: Y
authors.lastname: Jia
authors.affiliation: Division of Reproductive Medical Center, West China Second University Hospital, Sichuan University, Chengdu, Sichuan China ; Key Laboratory of Birth Defects and Related Diseases of Women and Children, West China Second University Hospital of Sichuan University, Chengdu, Sichuan China.
authors.forename: Shangwei
authors.initials: S
authors.lastname: Li
keywords: Genetic polymorphisms; Interleukin-10 (IL-10); Meta-analysis; Urologic cancer