title: [Validation and clinical application of MammaPrint®in patients with breast cancer].
abstract: BACKGROUND
  In recent years, advances in molecular biology have resulted in innovations in breast cancer diagnostics and therapeutics. The development of genomics has revolutionized our understanding of this disease. MammaPrint®was developed as a diagnostic tool to predict risk of breast cancer recurrence using the expression of 70 genes altering the clinicopathologic paradigm of selection of patients for adjuvant cytotoxic chemotherapy.
  
  
  METHODS
  A study of stage i-ii breast cancer patients on whom the MammaPrint®genomic assay was performed.
  
  
  RESULTS
  The use of the MammaPrint®assay was a decisive factor for the recommendation of adjuvant treatment with chemotherapy and/or hormone therapy in patients with high risk for relapse. In our group, the patients with low-risk have not presented local or systemic recurrences DISCUSSION: The determination of the genetic characteristics and its alterations in breast cancer, is fundamentally important for a better identification of risk, as well as a better selection of cancer therapy.
  
  
  CONCLUSIONS
  MammaPrint®is an effective study to determine risk of recurrence of in early stage breast cancer.
authors.affiliation: Servicio de Cirugía Oncológica, Mastológica Lomas, Centro de Estudios Mastológicos, S.A. de C.V., Ciudad de México, México. Electronic address: eforgach@gmail.com.
authors.forename: Ernesto Roberto
authors.initials: ER
authors.lastname: Sánchez-Forgach
authors.affiliation: Servicio de Cirugía Plástica y Reconstructiva, Mastológica Lomas, Centro de Estudios Mastológicos, S.A. de C.V., Ciudad de México, México.
authors.forename: Ubaldo
authors.initials: U
authors.lastname: Carpinteyro-Espín
authors.affiliation: Servicio de Ginecología y Obstetricia, Mastológica Lomas, Centro de Estudios Mastológicos, S.A. de C.V., Ciudad de México, México.
authors.forename: Jorge Alberto
authors.initials: JA
authors.lastname: Alemán-Áviles
authors.affiliation: Servicio de Cirugía Oncológica, Mastológica Lomas, Centro de Estudios Mastológicos, S.A. de C.V., Ciudad de México, México.
authors.forename: Carlos
authors.initials: C
authors.lastname: Sánchez-Basurto
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000235:genetics*; D005260:Female; D005820:Genetic Testing; D023281:Genomics; D006801:Humans; D008137:Longitudinal Studies; D008875:Middle Aged; D011446:Prospective Studies
keywords: Breast cancer; Chemotherapy; Cáncer de mama; Genomic; Genómico; Quimioterapia; Recurrence; Recurrencia