title: Online sensing of palladium in flowing streams.
abstract: Rapid palladium (Pd) catalyzed deallylation of an uncoloured reagent within a flowing stream affords a dose dependent colour formation that can be used for convenient online analysis of trace levels of Pd contamination using a modified HPLC instrument. An application to the online sensing of Pd breakthrough from a flow through Pd adsorption cartridge is described. An alternative configuration of the instrumentation allows the rapid (<1 min) and accurate measurement of Pd levels within samples injected via a conventional HPLC autosampler.
authors.affiliation: Department of Process Research and Development, Merck Research Laboratories, 126 East Lincoln Avenue, Rahway, NJ 07065, USA. christopher_welch@merck.com xiaodong_bu@merck.com.
authors.forename: Xiaodong
authors.identifier: http://orcid.org/0000-0001-6868-0282
authors.initials: X
authors.lastname: Bu
authors.affiliation: Department of Process Research and Development, Merck Research Laboratories, 126 East Lincoln Avenue, Rahway, NJ 07065, USA. christopher_welch@merck.com xiaodong_bu@merck.com.
authors.forename: Michael
authors.initials: M
authors.lastname: Williams
authors.affiliation: Department of Process Research and Development, Merck Research Laboratories, 126 East Lincoln Avenue, Rahway, NJ 07065, USA. christopher_welch@merck.com xiaodong_bu@merck.com.
authors.forename: Junyong
authors.identifier: http://orcid.org/0000-0002-5134-3754
authors.initials: J
authors.lastname: Jo
authors.affiliation: Department of Chemistry, University of Pittsburgh, 219 Parkman Avenue, Pittsburgh, Pennsylvania 15260, USA.
authors.forename: Kazunori
authors.identifier: http://orcid.org/0000-0001-8894-8485
authors.initials: K
authors.lastname: Koide
authors.affiliation: Department of Process Research and Development, Merck Research Laboratories, 126 East Lincoln Avenue, Rahway, NJ 07065, USA. christopher_welch@merck.com xiaodong_bu@merck.com.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Welch