title: A brain in flame; do inflammasomes and pyroptosis influence stroke pathology?
abstract: Stroke is one of the leading causes of death and disability worldwide. Inflammation plays a key role across the time course of stroke, from onset to the post-injury reparative phase days to months later. Several regulatory molecules are implicated in inflammation, but the most established inflammatory mediator of acute brain injury is the cytokine interleukin-1. Interleukin-1 is regulated by large, macromolecular complexes called inflammasomes, which play a central role in cytokine release and cell death. In this review we highlight recent advances in inflammasome research and propose key roles for inflammasome components in the progression of stroke damage.
authors.affiliation: Faculty of Biology, Medicine and Health, University of Manchester, AV Hill Building, Oxford Road, Manchester, M13 9PT, United Kingdom.
authors.forename: Jack
authors.initials: J
authors.lastname: Barrington
authors.affiliation: Faculty of Biology, Medicine and Health, University of Manchester, AV Hill Building, Oxford Road, Manchester, M13 9PT, United Kingdom.
authors.forename: Eloise
authors.initials: E
authors.lastname: Lemarchand
authors.affiliation: Faculty of Biology, Medicine and Health, University of Manchester, AV Hill Building, Oxford Road, Manchester, M13 9PT, United Kingdom.
authors.forename: Stuart M
authors.initials: SM
authors.lastname: Allan
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism / Q000473:pathology; D001930:Brain Injuries / Q000378:metabolism / Q000473:pathology; D020170:Caspase 1 / Q000378:metabolism / Q000502:physiology; D020169:Caspases / Q000378:metabolism / Q000502:physiology; D016923:Cell Death; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D006801:Humans; D058847:Inflammasomes / Q000378:metabolism / Q000502:physiology*; D007249:Inflammation / Q000276:immunology; D053583:Interleukin-1beta / Q000378:metabolism / Q000502:physiology; D051379:Mice; D000069292:Pyroptosis / Q000276:immunology / Q000502:physiology*; D020521:Stroke / Q000473:pathology*
chemical_list: D016207:Cytokines; D058847:Inflammasomes; D053583:Interleukin-1beta; D020169:Caspases; C000624929:caspase 11, human; D020170:Caspase 1
keywords: NLRP3; hemorrhagic stroke; inflammasome; inflammation; interleukin-1; ischemic stroke; pyroptosis