title: Inflammation in Chronic Wounds.
abstract: Non-healing chronic wounds present a major biological, psychological, social, and financial burden on both individual patients and the broader health system. Pathologically extensive inflammation plays a major role in the disruption of the normal healing cascade. The causes of chronic wounds (venous, arterial, pressure, and diabetic ulcers) can be examined through a juxtaposition of normal healing and the rogue inflammatory response created by the common components within chronic wounds (ageing, hypoxia, ischaemia-reperfusion injury, and bacterial colonisation). Wound bed care through debridement, dressings, and antibiotics currently form the basic mode of treatment. Despite recent setbacks, pharmaceutical adjuncts form an interesting area of research.
authors.affiliation: Sutton Arthritis Research Laboratory, Kolling Institute of Medical Research, University of Sydney, NSW 2065, Australia. rzha9073@uni.sydney.edu.au.
authors.forename: Ruilong
authors.initials: R
authors.lastname: Zhao
authors.affiliation: Sutton Arthritis Research Laboratory, Kolling Institute of Medical Research, University of Sydney, NSW 2065, Australia. helena.liang@sydney.edu.au.
authors.forename: Helena
authors.initials: H
authors.lastname: Liang
authors.affiliation: Murray Maxwell Biomechanics Laboratory, Kolling Institute of Medical Research, University of Sydney, NSW 2065, Australia. elizabeth.clarke@sydney.edu.au.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Clarke
authors.affiliation: Sutton Arthritis Research Laboratory, Kolling Institute of Medical Research, University of Sydney, NSW 2065, Australia. chris.jackson@sydney.edu.au.
authors.forename: Christopher
authors.initials: C
authors.lastname: Jackson
authors.affiliation: Sutton Arthritis Research Laboratory, Kolling Institute of Medical Research, University of Sydney, NSW 2065, Australia. meilang.xue@sydney.edu.au.
authors.forename: Meilang
authors.initials: M
authors.lastname: Xue
mesh_terms: D002908:Chronic Disease; D006801:Humans; D007249:Inflammation / Q000150:complications* / Q000473:pathology*; D012867:Skin / Q000473:pathology; D014945:Wound Healing; D014947:Wounds and Injuries / Q000150:complications* / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy
keywords: ageing; arterial ulcer; bacterial colonisation; chronic wound; diabetic ulcer; hypoxia; inflammation; ischaemia-reperfusion; pressure ulcer; venous ulcer