title: Proteomics in cardiovascular disease: recent progress and clinical implication and implementation.
abstract: Although multiple efforts have been initiated to shed light into the molecular mechanisms underlying cardiovascular disease, it still remains one of the major causes of death worldwide. Proteomic approaches are unequivocally powerful tools that may provide deeper understanding into the molecular mechanisms associated with cardiovascular disease and improve its management. Areas covered: Cardiovascular proteomics is an emerging field and significant progress has been made during the past few years with the aim of defining novel candidate biomarkers and obtaining insight into molecular pathophysiology. To summarize the recent progress in the field, a literature search was conducted in PubMed and Web of Science. As a result, 704 studies from PubMed and 320 studies from Web of Science were retrieved. Findings from original research articles using proteomics technologies for the discovery of biomarkers for cardiovascular disease in human are summarized in this review. Expert commentary: Proteins associated with cardiovascular disease represent pathways in inflammation, wound healing and coagulation, proteolysis and extracellular matrix organization, handling of cholesterol and LDL. Future research in the field should target to increase proteome coverage as well as integrate proteomics with other omics data to facilitate both drug development as well as clinical implementation of findings.
authors.affiliation: a Biotechnology Division, Biomedical Research Foundation Academy of Athens , Athens , Greece.
authors.forename: Marika
authors.initials: M
authors.lastname: Mokou
authors.affiliation: a Biotechnology Division, Biomedical Research Foundation Academy of Athens , Athens , Greece.
authors.forename: Vasiliki
authors.initials: V
authors.lastname: Lygirou
authors.affiliation: a Biotechnology Division, Biomedical Research Foundation Academy of Athens , Athens , Greece.
authors.forename: Antonia
authors.initials: A
authors.lastname: Vlahou
authors.affiliation: b Institute of Cardiovascular and Medical Sciences , University of Glasgow , Glasgow , UK.|c Mosaiques Diagnostics , Hannover , Germany.
authors.forename: Harald
authors.initials: H
authors.lastname: Mischak
mesh_terms: D000375:Aging; D001158:Arteries / Q000378:metabolism / Q000473:pathology; D015415:Biomarkers / Q000032:analysis* / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000378:metabolism* / Q000473:pathology; D004032:Diet; D005109:Extracellular Matrix / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D009206:Myocardium / Q000378:metabolism; D058226:Plaque, Atherosclerotic / Q000378:metabolism / Q000473:pathology; D046188:Protein Modification, Translational; D040901:Proteomics / Q000379:methods*; D006435:Renal Dialysis
chemical_list: D015415:Biomarkers
keywords: Cardiovascular disease; biomarker; clinical proteomics; proteome; vascular disease