title: Olmesartan-induced Enteropathy Manifesting as Wernicke-Korsakoff Syndrome.
abstract: Cases of sprue-like enteropathy associated with olmesartan have sporadically been encountered since it was first reported in 2012, and their most characteristic manifestation is severe diarrhea. We herein report the first case of sprue-like enteropathy manifesting as Wernicke-Korsakoff syndrome due to vitamin B1 malabsorption with only minimally increased bowel movements. When patients are receiving olmesartan and they complain of nonspecific chronic gastrointestinal symptoms, it is important to consider changing the drugs before any serious malabsorption syndrome develops.
authors.affiliation: Department of General Medicine, Chiba University Hospital, Japan.
authors.forename: Takanori
authors.initials: T
authors.lastname: Uehara
authors.forename: Masatomi
authors.initials: M
authors.lastname: Ikusaka
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Ohira
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Noda
authors.forename: Shingo
authors.initials: S
authors.lastname: Suzuki
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Shikino
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kondo
authors.forename: Hideki
authors.initials: H
authors.lastname: Kajiwara
authors.forename: Akiko
authors.initials: A
authors.lastname: Ikegami
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Hirota
mesh_terms: D000368:Aged; D002446:Celiac Disease / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D003937:Diagnosis, Differential; D003967:Diarrhea / Q000139:chemically induced / Q000175:diagnosis / Q000503:physiopathology; D006801:Humans; D007093:Imidazoles / Q000009:adverse effects* / Q000627:therapeutic use; D020915:Korsakoff Syndrome / Q000175:diagnosis* / Q000503:physiopathology; D008297:Male; D012307:Risk Factors; D013777:Tetrazoles / Q000009:adverse effects* / Q000627:therapeutic use; D013831:Thiamine / Q000378:metabolism; D016896:Treatment Outcome; D014803:Vitamin B Complex / Q000378:metabolism
chemical_list: D007093:Imidazoles; D013777:Tetrazoles; D014803:Vitamin B Complex; C437965:olmesartan; D013831:Thiamine