title: Effect of telmisartan on kidney function in patients with chronic kidney disease: an observational study.
abstract: Background:Globally the burden of chronic kidney disease (CKD) is rising, an important cause of death and loss of disability-adjusted life years. Activation of the renin-angiotensin-aldosterone system is involved in its pathogenesis. The aim of the present study was to examine the effects of telmisartan (40 mg/day), an angiotensin receptor blocker (ARB) in Indian patients with CKD in real-life setting.Method:This was a prospective observational study. Fifty-six patients (>18 years) diagnosed with CKD were enrolled into the study. Serum creatinine, 24-h urinary protein, spot urine protein-to-creatinine ratio, glomerular filtration rate (GFR) and blood pressure (BP) were assessed along with safety.Results:A total of 55 patients (96.36% hypertensive; 63.61% diabetic) with mean age of 48.23 years completed the study. At the end of 3 months treatment with telmisartan, 24-h urinary protein, spot urine protein-to-creatinine, serum creatinine and BP significantly reduced (p< .05) by 806.78 mg, 0.95, 0.44 mg/dl and 8.9/4.7 mmHg in the overall population. GFR increased from the baseline value of 52.13 to 65.01 ml/min. Telmisartan was well tolerated and treatment was discontinued in one patient because of hyperkalemia.Conclusion:This study demonstrated that telmisartan effectively and safely reduces proteinuria in chronic kidney disease patients.
authors.affiliation: Department of Pharmacy, Bharat Institute of Technology , Ranga Reddy , Telangana , India.
authors.forename: Ashish
authors.initials: A
authors.lastname: Agrawal
authors.affiliation: Department of Pharmacy, Bharat Institute of Technology , Ranga Reddy , Telangana , India.
authors.forename: Shibnath
authors.initials: S
authors.lastname: Kamila
authors.affiliation: Department of Pharmacy, Bharat Institute of Technology , Ranga Reddy , Telangana , India.
authors.forename: Swetha
authors.initials: S
authors.lastname: Reddy
authors.affiliation: Department of Pharmacy, Bharat Institute of Technology , Ranga Reddy , Telangana , India.
authors.forename: Joyal
authors.initials: J
authors.lastname: Lilly
authors.affiliation: Department of Pharmacy, Bharat Institute of Technology , Ranga Reddy , Telangana , India.
authors.forename: Ms Sadhguna
authors.initials: MS
authors.lastname: Mariyala
keywords: Chronic kidney disease; proteinuria; telmisartan