title: Progress in ciliary ion channel physiology.
abstract: Mammalian cilia are ubiquitous appendages found on the apical surface of cells. Primary and motile cilia are distinct in both morphology and function. Most cells have a solitary primary cilium (9+0), which lacks the central microtubule doublet characteristic of motile cilia (9+2). The immotile primary cilia house unique signaling components and sequester several important transcription factors. In contrast, motile cilia commonly extend into the lumen of respiratory airways, fallopian tubes, and brain ventricles to move their contents and/or produce gradients. In this review, we focus on the composition of putative ion channels found in both types of cilia and in the periciliary membrane and discuss their proposed functions. Our discussion does not cover specialized cilia in photoreceptor or olfactory cells, which express many more ion channels.
authors.affiliation: Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA 02115.|Department of Cardiology, Boston Children's Hospital, Boston, MA 02115.|Department of Neurobiology, Harvard Medical School, Boston, MA 02115.
authors.forename: Juan Lorenzo
authors.initials: JL
authors.lastname: Pablo
authors.affiliation: Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.
authors.forename: Paul G
authors.initials: PG
authors.lastname: DeCaen
authors.affiliation: Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA 02115 dclapham@enders.tch.harvard.edu.|Department of Cardiology, Boston Children's Hospital, Boston, MA 02115.|Department of Neurobiology, Harvard Medical School, Boston, MA 02115.
authors.forename: David E
authors.identifier: http://orcid.org/0000-0002-4459-9428
authors.initials: DE
authors.lastname: Clapham
mesh_terms: D000818:Animals; D002923:Cilia / Q000502:physiology*; D006801:Humans; D015640:Ion Channel Gating / Q000502:physiology; D007473:Ion Channels / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D007473:Ion Channels