title: Assessment of relationship on excess arsenic intake from drinking water and cognitive impairment in adults and elders in arsenicosis areas.
abstract: In this study, the relationships between high water arsenic exposure and cognitive impairment were investigated. A total of 483 residents aged 40 or older were randomly recruited and were divided into four groups according to the concentrations of arsenic in their water. Consumption levels (̄x¯±sd) of drinking water arsenic for normal, mild, moderate, and high exposure groups were 4±2μg/L, 25±11μg/L, 73±15μg/L, and 183±88μg/L, respectively. The average scores (̄x¯±sd) of the Chinese version Mini-Mental State Examination (MMSE) for females in each group were 21.49±3.14, 19.04±5.87, 16.18±8.14, and 15.82±7.78, and the average scores (̄x¯±sd) for males were 24.50±3.97, 23.16±4.45, 21.00±6.57, and 18.92±7.99, respectively. Significant differences among the average scores of MMSE for males or females in the four groups were found (p<0.05). The prevalence of cognitive impairment for females in each group was 10.86%, 29.63%, 53.48%, and 55.29%, and the prevalence of cognitive impairment for males was 10.71%, 12.00%, 35.71%, and 50.89%, respectively. Significant differences between all groups were observed (p<0.05). In the multivariable regress model, high water was closely associated with the MMSE score (Standardized Coefficient=-0.021) and cognitive impairment (arsenic ˃100 μg/L PR4/1=4.01). The findings of our research suggested a significant positive relationship between arsenic exposure from drinking water and cognitive impairment.
authors.affiliation: Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Key lab of Etiology and Epidemiology, Education Bureau of Heilongjiang Province & Ministry of Health, China and Russia Medical Research Center, Harbin Medical University, 157 Baojian Road, Harbin, 150081, China.
authors.forename: Jiayong
authors.initials: J
authors.lastname: Liu
authors.affiliation: Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Key lab of Etiology and Epidemiology, Education Bureau of Heilongjiang Province & Ministry of Health, China and Russia Medical Research Center, Harbin Medical University, 157 Baojian Road, Harbin, 150081, China.
authors.forename: Yanhui
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Key lab of Etiology and Epidemiology, Education Bureau of Heilongjiang Province & Ministry of Health, China and Russia Medical Research Center, Harbin Medical University, 157 Baojian Road, Harbin, 150081, China.
authors.forename: Hongxu
authors.initials: H
authors.lastname: Liu
authors.affiliation: Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Key lab of Etiology and Epidemiology, Education Bureau of Heilongjiang Province & Ministry of Health, China and Russia Medical Research Center, Harbin Medical University, 157 Baojian Road, Harbin, 150081, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Sun
authors.affiliation: Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Key lab of Etiology and Epidemiology, Education Bureau of Heilongjiang Province & Ministry of Health, China and Russia Medical Research Center, Harbin Medical University, 157 Baojian Road, Harbin, 150081, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Key lab of Etiology and Epidemiology, Education Bureau of Heilongjiang Province & Ministry of Health, China and Russia Medical Research Center, Harbin Medical University, 157 Baojian Road, Harbin, 150081, China.
authors.forename: Junhua
authors.initials: J
authors.lastname: Wu
authors.affiliation: Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Key lab of Etiology and Epidemiology, Education Bureau of Heilongjiang Province & Ministry of Health, China and Russia Medical Research Center, Harbin Medical University, 157 Baojian Road, Harbin, 150081, China.
authors.forename: Dandan
authors.initials: D
authors.lastname: Li
authors.affiliation: Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Key lab of Etiology and Epidemiology, Education Bureau of Heilongjiang Province & Ministry of Health, China and Russia Medical Research Center, Harbin Medical University, 157 Baojian Road, Harbin, 150081, China. Electronic address: hrbmusdj@163.com.
authors.forename: Dianjun
authors.initials: D
authors.lastname: Sun
mesh_terms: D000328:Adult; D000368:Aged; D001151:Arsenic / Q000032:analysis*; D020261:Arsenic Poisoning / Q000453:epidemiology*; D002681:China / Q000453:epidemiology; D060825:Cognitive Dysfunction / Q000453:epidemiology*; D060766:Drinking Water / Q000032:analysis*; D004781:Environmental Exposure / Q000032:analysis*; D005260:Female; D060587:Groundwater / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D011581:Psychological Tests; D014874:Water Pollutants, Chemical / Q000032:analysis*
chemical_list: D060766:Drinking Water; D014874:Water Pollutants, Chemical; D001151:Arsenic
keywords: Arsenicosis; Cognitive impairment; Risk factors; Water arsenic concentration