title: Gene Variations in the Protein C and Fibrinolytic Pathway: Relevance for Severity and Outcome in Pediatric Sepsis.
abstract: The host response to infection involves complex interplays between inflammation, coagulation, and fibrinolysis. Deregulation of hemostasis and fibrinolysis are major causes of critical illness and important determinants of outcome in severe sepsis. The hemostatic responses to infection vary widely between individuals, and are in part explained by polymorphisms in genes responsible for the protein C and fibrinolytic pathway. This review gives an overview of genetic polymorphisms in the protein C and fibrinolytic pathway associated with susceptibility and severity of pediatric sepsis. In addition, genetic polymorphisms associated with adult sepsis and other pediatric thromboembolic disorders are discussed, as these polymorphisms might be candidates for future molecular genetic research in pediatric sepsis.
authors.affiliation: Intensive Care and Department of Pediatric Surgery, Erasmus MC-Sophia Children's Hospital, University Medical Center Rotterdam, Rotterdam, The Netherlands.
authors.forename: Navin P
authors.initials: NP
authors.lastname: Boeddha
authors.affiliation: Department of Paediatric Infectious Diseases and Immunology, Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom.
authors.forename: Marieke
authors.initials: M
authors.lastname: Emonts
authors.affiliation: Division of Pediatric Hematology, Department of Pediatrics, Erasmus MC-Sophia Children's Hospital, University Medical Center Rotterdam, Rotterdam, The Netherlands.
authors.forename: Marjon H
authors.initials: MH
authors.lastname: Cnossen
authors.affiliation: Department of Hematology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
authors.forename: Moniek P
authors.initials: MP
authors.lastname: de Maat
authors.affiliation: Department of Hematology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
authors.forename: Frank W
authors.initials: FW
authors.lastname: Leebeek
authors.affiliation: Division of Pediatric Infectious Diseases and Immunology, Department of Pediatrics, Erasmus MC-Sophia Children's Hospital, University Medical Center Rotterdam, Rotterdam, The Netherlands.
authors.forename: Gertjan J
authors.initials: GJ
authors.lastname: Driessen
authors.affiliation: Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
authors.forename: Jan A
authors.initials: JA
authors.lastname: Hazelzet
mesh_terms: D016638:Critical Illness; D005342:Fibrinolysis / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic; D011486:Protein C / Q000235:genetics*; D018805:Sepsis / Q000097:blood / Q000235:genetics*
chemical_list: D011486:Protein C