title: Autologous Adipose Stem Cell Therapy for Autonomic Nervous System Dysfunction in Two Young Patients.
abstract: Postural orthostatic tachycardia syndrome and neurocardiogenic syncope are clinical manifestations of autonomic nervous system dysfunction (dysautonomia) that can lead to impaired daily functions. We report two young patients presenting with dysautonomia and autoimmune disease who both received autologous adipose stem cells (ASCs) infusions. This report is the first description of ASCs therapy for patients with combined dysautonomia and autoimmune disease. Case 1: A 21-year-old female presented at 12 years of age with escalating severe dysautonomia with weight loss and gastrointestinal symptoms. She had elevated autoantibodies and cytokines and received multiple immune modulation therapies. Her dysautonomia was treated by volume expanders, vasoconstrictors, and beta blockers with mild improvement. She received ASCs about 2 years before this report with dramatic improvement in her dysautonomia and autoimmune symptoms with a 10 kg weight gain. Case 2: A 7-year-old boy presented at 2 years of age with polyarthritis. At 5 years of age, he manifested orthostatic intolerance. He received immune modulatory therapies with mild improvement. He received ASCs and showed marked improvement of his dysautonomia and immune symptoms. Dysautonomia symptoms of these two patients improved significantly after modulation of autoimmune components by ASC therapy. Favorable clinical responses of these two cases warrant further case-control studies.
authors.affiliation: 1 Department of Pediatrics, McGovern Medical School, The University of Texas Health Science Center , Houston, Texas.
authors.forename: Mohammed T
authors.initials: MT
authors.lastname: Numan
authors.affiliation: 1 Department of Pediatrics, McGovern Medical School, The University of Texas Health Science Center , Houston, Texas.
authors.forename: Ankur
authors.initials: A
authors.lastname: Kamdar
authors.affiliation: 2 Celltex Therapeutics Corporation , Houston, Texas.
authors.forename: Jane
authors.initials: J
authors.lastname: Young
authors.affiliation: 1 Department of Pediatrics, McGovern Medical School, The University of Texas Health Science Center , Houston, Texas.
authors.forename: Ian J
authors.initials: IJ
authors.lastname: Butler
mesh_terms: D000273:Adipose Tissue / Q000166:cytology*; D001341:Autonomic Nervous System / Q000503:physiopathology*; D015415:Biomarkers / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D033581:Stem Cell Transplantation; D014182:Transplantation, Autologous; D055815:Young Adult
chemical_list: D015415:Biomarkers
keywords: CNS; concise report; immunogenicity