title: Asymmetric Inverse-Electron-Demand Oxa-Diels-Alder Reaction of Allylic Ketones through Dienamine Catalysis.
abstract: A remote β,γ-regioselective asymmetric inverse-electron-demand oxa-Diels-Alder reaction between allylic ketones and α-cyano-α,β-unsaturated ketones has been developed through induced extended dienamine catalysis of a cinchona-derived primary amine. A spectrum of densely substituted dihydropyran frameworks were efficiently produced with excellent enantioselectivity and fair to exclusive diastereoselectivity.
authors.affiliation: Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University , Chengdu 610041, China.
authors.forename: Ming-Lin
authors.initials: ML
authors.lastname: Shi
authors.affiliation: Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University , Chengdu 610041, China.
authors.forename: Gu
authors.initials: G
authors.lastname: Zhan
authors.affiliation: Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University , Chengdu 610041, China.
authors.forename: Su-Lan
authors.initials: SL
authors.lastname: Zhou
authors.affiliation: Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University , Chengdu 610041, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Du
authors.affiliation: Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University , Chengdu 610041, China.|College of Pharmacy, Third Military Medical University , Shapingba, Chongqing 400038, China.
authors.forename: Ying-Chun
authors.identifier: 0000-0003-1902-0979
authors.initials: YC
authors.lastname: Chen