title: Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors.
abstract: We recently reported that atypical teratoid rhabdoid tumors (ATRTs) comprise at least two transcriptional subtypes with different clinical outcomes; however, the mechanisms underlying therapeutic heterogeneity remained unclear. In this study, we analyzed 191 primary ATRTs and 10 ATRT cell lines to define the genomic and epigenomic landscape of ATRTs and identify subgroup-specific therapeutic targets. We found ATRTs segregated into three epigenetic subgroups with distinct genomic profiles, SMARCB1 genotypes, and chromatin landscape that correlated with differential cellular responses to a panel of signaling and epigenetic inhibitors. Significantly, we discovered that differential methylation of a PDGFRB-associated enhancer confers specific sensitivity of group 2 ATRT cells to dasatinib and nilotinib, and suggest that these are promising therapies for this highly lethal ATRT subtype.
authors.affiliation: Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada; Department of Paediatrics, University of Toronto, Toronto, ON M5G0A4, Canada; Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
authors.forename: Jonathon
authors.initials: J
authors.lastname: Torchia
authors.affiliation: Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada; Division of Neurosurgery, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
authors.forename: Brian
authors.initials: B
authors.lastname: Golbourn
authors.affiliation: Department of Medical Biophysics, University of Toronto, Toronto, ON M5G0A4, Canada; Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada.
authors.forename: Shengrui
authors.initials: S
authors.lastname: Feng
authors.affiliation: Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
authors.forename: King Ching
authors.initials: KC
authors.lastname: Ho
authors.affiliation: Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada; Department of Paediatrics, University of Toronto, Toronto, ON M5G0A4, Canada; Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
authors.forename: Patrick
authors.initials: P
authors.lastname: Sin-Chan
authors.affiliation: Department of Pathology, Groupement Hospitalier Est, CHU de Lyon, Lyon-Bron 69677, France.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Vasiljevic
authors.affiliation: Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
authors.forename: Joseph D
authors.initials: JD
authors.lastname: Norman
authors.affiliation: Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada.
authors.forename: Paul
authors.initials: P
authors.lastname: Guilhamon
authors.affiliation: Program in Developmental & Stem Cell Biology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
authors.forename: Livia
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authors.lastname: Garzia
authors.affiliation: Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
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authors.initials: NR
authors.lastname: Agamez
authors.affiliation: Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
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authors.affiliation: Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada; Department of Paediatrics, University of Toronto, Toronto, ON M5G0A4, Canada; Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
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authors.initials: TS
authors.lastname: Chan
authors.affiliation: Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
authors.forename: Daniel
authors.initials: D
authors.lastname: Picard
authors.affiliation: Program in Developmental & Stem Cell Biology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
authors.forename: Pasqualino
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authors.lastname: de Antonellis
authors.affiliation: Department of Pediatrics, McGill University, Montreal, QC H3Z2Z3, Canada; Department of Human Genetics, McGill University, Montreal, QC H3Z2Z3, Canada.
authors.forename: Dong-Anh
authors.initials: DA
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authors.affiliation: Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada.
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authors.affiliation: Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada.
authors.forename: Dalia
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authors.affiliation: Division of Pediatric Hematology/Oncology, Alberta Children's Hospital, AB T3B6A8, Canada.
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authors.affiliation: Genome Quebec Innovation Centre, McGill University, Montreal, QC H3A1A4, Canada.
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authors.affiliation: Genome Quebec Innovation Centre, McGill University, Montreal, QC H3A1A4, Canada.
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authors.affiliation: Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
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authors.affiliation: Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
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authors.affiliation: Division of Neurosurgery, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
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authors.initials: AN
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authors.affiliation: Program in Developmental & Stem Cell Biology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
authors.forename: A Sorana
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authors.affiliation: Department of Neurosurgery, Asan Medical Center, Seoul 138-736, Korea.
authors.forename: Young-Shin
authors.initials: YS
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authors.affiliation: Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
authors.forename: Vijay
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authors.lastname: Ramaswamy
authors.affiliation: Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
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authors.initials: CP
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authors.affiliation: Department of Pathology & Laboratory Medicine, University of British Columbia, V6T1Z3, Canada.
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authors.affiliation: Department of Anatomical and Cellular Pathology, Chinese University of Hong Kong, Hong Kong, China.
authors.forename: Ho-Keung
authors.initials: HK
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authors.affiliation: Laboratory Medicine and Pathology, Stollery Children's Hospital, University of Alberta, Edmonton, AB T2W3N2, Canada.
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authors.initials: JQ
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authors.affiliation: Division of Neurosurgery, Stollery Children's Hospital, University of Alberta, Edmonton, AB T2W3N2, Canada.
authors.forename: Vivek
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authors.affiliation: Department of Pathology, McGill University, Montreal, QC H3Z2Z3, Canada.
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authors.affiliation: Divison of Pathology, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Lisbon 1649-035, Portugal.
authors.forename: Jose
authors.initials: J
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authors.affiliation: Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, AB T2N1N4, Canada.
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authors.initials: JA
authors.lastname: Chan
authors.affiliation: Department of Paediatric Laboratory Medicine, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
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authors.initials: GR
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authors.affiliation: Department of Neurosurgery, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Lisbon 1649-035, Portugal.
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authors.affiliation: Cytometry and Cytogenetic Laboratory, CIPM, Portuguese Cancer Institute, Lisbon 1099-023, Portugal.
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authors.affiliation: Division of Oncology, Department of Cancer and Blood Diseases, Cincinnati Children's Hospital, Cincinnati, OH 45229, USA.
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authors.affiliation: Department of Pediatrics, University of Colorado, Denver, CO 80045, USA.
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authors.affiliation: Oncology Service, Children's Health Queensland Hospital; University of Queensland Diamantina Institute, Brisbane, QLD 4102, Australia.
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authors.affiliation: Research Institute of Health Development Strategies, Fudan University, Shanghai 200032, China.
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authors.affiliation: Division of Pediatric Neurosurgery, Seoul National University Children's Hospital, Seoul 03080, Korea.
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authors.initials: SA
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authors.affiliation: Royal Children's Hospital, Murdoch Children's Research Institute, Melbourne, VIC 3052, Australia.
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authors.affiliation: Children's Cancer Research Unit, Children's Hospital at Westmead, Westmead, NSW 2145, Australia.
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authors.affiliation: Department of Pediatrics, University of Colorado, Denver, CO 80045, USA.
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authors.affiliation: Department of Pediatrics, University of Colorado, Denver, CO 80045, USA.
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authors.lastname: Foreman
authors.affiliation: Division of Pediatric Hematology/Oncology, Stollery Children's Hospital, University of Alberta, Edmonton, AB T2W3N2, Canada.
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authors.initials: D
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authors.affiliation: Department of Neurosurgery, University of Debrecen, Debrecen 4032, Hungary.
authors.forename: Almos
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authors.affiliation: Department of Neurosurgery, University of Debrecen, Debrecen 4032, Hungary.
authors.forename: Laszló
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authors.affiliation: Second Department of Pediatrics, Semmelweis University, Budapest 1094, Hungary.
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authors.affiliation: Second Department of Pediatrics, Semmelweis University, Budapest 1094, Hungary.
authors.forename: Péter
authors.initials: P
authors.lastname: Hauser
authors.affiliation: Department of Histopathology, University of Szeged, Szeged 6720, Hungary.
authors.forename: Tibor
authors.initials: T
authors.lastname: Hortobágyi
authors.affiliation: Division of Pediatric Hematology/Oncology, Stollery Children's Hospital, University of Alberta, Edmonton, AB T2W3N2, Canada.
authors.forename: Beverly
authors.initials: B
authors.lastname: Wilson
authors.affiliation: Division of Hematology and Oncology, Children's and Women's Health Centre of B.C, University of British Columbia, Vancouver, BC V6H3N1, Canada.
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authors.affiliation: Department of Pediatrics, Division of Hematology-Oncology, Université de Montréal/CHU Sainte-Justine, Montreal, QC H3T1C5, Canada.
authors.forename: Anne-Sophie
authors.initials: AS
authors.lastname: Carret
authors.affiliation: Department of Neurosurgery, Virginia Commonwealth University, Richmond, VA 23298-0631, USA.
authors.forename: Timothy E
authors.initials: TE
authors.lastname: Van Meter
authors.affiliation: Department of Oncology, Children's National Medical Center, Washington, DC 20010, USA.
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authors.affiliation: Division of Neuro-Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
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authors.affiliation: Department of Medical Research, Taipei Veterans General Hospital and National Yang-Ming University, Taipei 112, Taiwan.
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authors.initials: SH
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authors.affiliation: Department of Neurosurgery, Kumamoto University, Kumamoto 860-8556, Japan.
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authors.affiliation: Department of Pediatric Hematology Oncology, Children's Medical Center of Israel, Petach Tikva 49202, Isreal.
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authors.initials: H
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authors.affiliation: Department of Pediatric Hematology-Oncology, Hadassah Hebrew University Medical Center, Jerusalem 91120, Israel.
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authors.affiliation: Department of Neurosurgery, University of Utah, School of Medicine, Salt Lake City, UT 84132, USA.
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authors.affiliation: Department of Neurosurgery, Shizuoka Children's Hospital, Shizuoka 420-8660, Japan.
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authors.affiliation: Division of Hematology and Oncology, Children's and Women's Health Centre of B.C, University of British Columbia, Vancouver, BC V6H3N1, Canada.
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authors.affiliation: Division of Pediatric Hematology/Oncology, Stollery Children's Hospital, University of Alberta, Edmonton, AB T2W3N2, Canada.
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authors.affiliation: Department of Pediatrics, McMaster University, Hamilton, ON L8S4K1, Canada.
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authors.affiliation: Department of Pediatrics, McMaster University, Hamilton, ON L8S4K1, Canada.
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authors.affiliation: Department of Pediatrics, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, ON K1H8L1, Canada.
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authors.affiliation: Pathology and Laboratory Medicine, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, ON K1H8L1, Canada.
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authors.affiliation: Division of Pediatric Hematology/Oncology, Children's Hospital, London Health Sciences Center, London, ON N6A5A5, Canada.
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authors.affiliation: Department of Pathology and Laboratory Medicine, Children's Hospital of Western Ontario, University of Western Ontario, London, ON N6A5W9, Canada.
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authors.lastname: Hammond
authors.affiliation: Department of Pediatrics, Dalhousie University, Halifax, NS B3H4R2, Canada.
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authors.lastname: Afzal
authors.affiliation: Department of Pathology and Laboratory Medicine, Children's Hospital of Western Ontario, University of Western Ontario, London, ON N6A5W9, Canada.
authors.forename: David A
authors.initials: DA
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authors.affiliation: Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10300, Thailand.
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authors.affiliation: Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10300, Thailand.
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authors.affiliation: Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
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authors.affiliation: Children's Brain Tumour Research Centre, University of Nottingham, Nottingham NG72RD, England.
authors.forename: Richard G
authors.initials: RG
authors.lastname: Grundy
authors.affiliation: Division of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL 60611, USA.
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authors.initials: RR
authors.lastname: Lulla
authors.affiliation: Division of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL 60611, USA.
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authors.initials: JR
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authors.affiliation: Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
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authors.affiliation: Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
authors.forename: Ute
authors.initials: U
authors.lastname: Bartels
authors.affiliation: Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
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authors.initials: R
authors.lastname: Grant
authors.affiliation: Department of Paediatrics, University of Toronto, Toronto, ON M5G0A4, Canada; Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Program in Genetics & Genome Biology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
authors.forename: David
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authors.lastname: Malkin
authors.affiliation: Department of Medical Biophysics, University of Toronto, Toronto, ON M5G0A4, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
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authors.initials: CJ
authors.lastname: McGlade
authors.affiliation: Department of Pediatrics (Hematology/Oncology), University of California, San Francisco, San Francisco, CA 94143-0112, USA.
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authors.initials: T
authors.lastname: Nicolaides
authors.affiliation: Department of Neurosurgery, University of California, San Francisco, San Francisco, CA 94143-0112, USA.
authors.forename: Tarik
authors.initials: T
authors.lastname: Tihan
authors.affiliation: Department of Neurosurgery, University of California, San Francisco, San Francisco, CA 94143-0112, USA.
authors.forename: Joanna
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authors.lastname: Phillips
authors.affiliation: Department of Human Genetics, McGill University, Montreal, QC H3Z2Z3, Canada; Genome Quebec Innovation Centre, McGill University, Montreal, QC H3A1A4, Canada.
authors.forename: Jacek
authors.initials: J
authors.lastname: Majewski
authors.affiliation: Genome Quebec Innovation Centre, McGill University, Montreal, QC H3A1A4, Canada.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Montpetit
authors.affiliation: Department of Human Genetics, McGill University, Montreal, QC H3Z2Z3, Canada; Genome Quebec Innovation Centre, McGill University, Montreal, QC H3A1A4, Canada.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Bourque
authors.affiliation: Department of Molecular Genetics, University of Toronto, Toronto, ON M5G0A4, Canada.
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authors.initials: GD
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authors.affiliation: Department of Pediatric Hematology and Oncology, University of Alabama, Birmingham, AL 35233, USA.
authors.forename: Alyssa T
authors.initials: AT
authors.lastname: Reddy
authors.affiliation: Department of Neurosurgery, University of Alabama, Birmingham, AL 35233, USA.
authors.forename: G Yancey
authors.initials: GY
authors.lastname: Gillespie
authors.affiliation: Department of Neuroradiology, University of Würzburg, Würzburg 97070, Germany.
authors.forename: Monika
authors.initials: M
authors.lastname: Warmuth-Metz
authors.affiliation: Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.
authors.forename: Stefan
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authors.lastname: Rutkowski
authors.affiliation: Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada; Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Program in Genetics & Genome Biology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
authors.forename: Uri
authors.initials: U
authors.lastname: Tabori
authors.affiliation: Department of Medical Biophysics, University of Toronto, Toronto, ON M5G0A4, Canada; Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada.
authors.forename: Mathieu
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authors.lastname: Lupien
authors.affiliation: Department of Computer Science, University of Toronto, Toronto, ON M5G0A4, Canada; Program in Genetics & Genome Biology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
authors.forename: Michael
authors.initials: M
authors.lastname: Brudno
authors.affiliation: Department of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Schüller
authors.affiliation: Institute for Neuropathology, University of Bonn Medical Center, Bonn 53105, Germany.
authors.forename: Torsten
authors.initials: T
authors.lastname: Pietsch
authors.affiliation: Department of Pathology & Laboratory Medicine, Children's Hospital of Los Angeles, Los Angeles, CA 90027, USA.
authors.forename: Alexander R
authors.initials: AR
authors.lastname: Judkins
authors.affiliation: Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada; Division of Pathology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
authors.forename: Cynthia E
authors.initials: CE
authors.lastname: Hawkins
authors.affiliation: Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
authors.forename: Eric
authors.initials: E
authors.lastname: Bouffet
authors.affiliation: Division of Pediatric Neurosurgery, Seoul National University Children's Hospital, Seoul 03080, Korea.
authors.forename: Seung-Ki
authors.initials: SK
authors.lastname: Kim
authors.affiliation: Division of Neurosurgery, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
authors.forename: Peter B
authors.initials: PB
authors.lastname: Dirks
authors.affiliation: Division of Neurosurgery, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Program in Developmental & Stem Cell Biology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Taylor
authors.affiliation: Department of Pediatrics, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA.
authors.forename: Anat
authors.initials: A
authors.lastname: Erdreich-Epstein
authors.affiliation: Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada.
authors.forename: Cheryl H
authors.initials: CH
authors.lastname: Arrowsmith
authors.affiliation: Department of Medical Biophysics, University of Toronto, Toronto, ON M5G0A4, Canada; Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada. Electronic address: ddecarv@uhnresearch.ca.
authors.forename: Daniel D
authors.initials: DD
authors.lastname: De Carvalho
authors.affiliation: Department of Surgery, University of Toronto, Toronto, ON M5G0A4, Canada; Division of Neurosurgery, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada. Electronic address: james.rutka@sickkids.ca.
authors.forename: James T
authors.initials: JT
authors.lastname: Rutka
authors.affiliation: Department of Pediatrics, McGill University, Montreal, QC H3Z2Z3, Canada; Department of Human Genetics, McGill University, Montreal, QC H3Z2Z3, Canada. Electronic address: nada.jabado@mcgill.ca.
authors.forename: Nada
authors.initials: N
authors.lastname: Jabado
authors.affiliation: Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada; Department of Paediatrics, University of Toronto, Toronto, ON M5G0A4, Canada; Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada. Electronic address: annie.huang@sickkids.ca.
authors.forename: Annie
authors.initials: A
authors.lastname: Huang
mesh_terms: D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D016543:Central Nervous System Neoplasms / Q000188:drug therapy / Q000235:genetics*; D002843:Chromatin / Q000235:genetics*; D019175:DNA Methylation; D000069439:Dasatinib / Q000494:pharmacology / Q000627:therapeutic use; D044127:Epigenesis, Genetic / Q000187:drug effects; D057890:Epigenomics / Q000379:methods*; D006801:Humans; D009154:Mutation; D047428:Protein Kinase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D011743:Pyrimidines / Q000494:pharmacology / Q000627:therapeutic use; D020797:Receptor, Platelet-Derived Growth Factor beta / Q000037:antagonists & inhibitors / Q000235:genetics*; D018335:Rhabdoid Tumor / Q000188:drug therapy / Q000235:genetics*; D000071796:SMARCB1 Protein / Q000235:genetics*; D013724:Teratoma / Q000188:drug therapy / Q000235:genetics*
chemical_list: D002843:Chromatin; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D000071796:SMARCB1 Protein; C513266:SMARCB1 protein, human; C000605860:PDGFRB protein, human; D020797:Receptor, Platelet-Derived Growth Factor beta; C498826:nilotinib; D000069439:Dasatinib
keywords: ATRT; enhancer; epigenomics; genomics; rhabdoid tumors; subgroup-specific therapeutics