title: Childhood trauma and emotional processing circuits in schizophrenia: A functional connectivity study.
abstract: Childhood trauma strongly impacts emotional responses in schizophrenia. We have explored an association between early trauma and the amygdala functional connectivity using generalized psychophysiological interaction during an emotional task. Twenty-one schizophrenia patients and twenty-five controls were included. In schizophrenia patients, higher levels of sexual abuse and physical neglect during childhood were associated with decreased connectivity between the amygdala and the posterior cingulate/precuneus region. Additionally, patients showed decreased coupling between the amygdala and the posterior cingulate/precuneus region compared to controls. These findings suggest that early trauma could impact later connectivity in specific stress-related circuits affecting self-consciousness and social cognition in schizophrenia.
authors.affiliation: Timone Institute of Neuroscience, UMR 7289, CNRS and Aix-Marseille University, Marseille, France; Department of Psychiatry, University Hospital of Saint-Etienne, Saint-Etienne, France. Electronic address: aida.cancel@hotmail.fr.
authors.forename: Aïda
authors.initials: A
authors.lastname: Cancel
authors.affiliation: Timone Institute of Neuroscience, UMR 7289, CNRS and Aix-Marseille University, Marseille, France.
authors.forename: Magali
authors.initials: M
authors.lastname: Comte
authors.affiliation: Inserm U1059, Univ Lyon, Department of Radiology, University Hospital of Saint-Etienne, Saint-Etienne, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Boutet
authors.affiliation: Inserm U1059, Univ Lyon, Department of Radiology, University Hospital of Saint-Etienne, Saint-Etienne, France.
authors.forename: Fabien C
authors.initials: FC
authors.lastname: Schneider
authors.affiliation: Timone Institute of Neuroscience, UMR 7289, CNRS and Aix-Marseille University, Marseille, France; Psychiatry Unit, Saint Anne Military Training Hospital, Toulon, France.
authors.forename: Pierre-François
authors.initials: PF
authors.lastname: Rousseau
authors.affiliation: Timone Institute of Neuroscience, UMR 7289, CNRS and Aix-Marseille University, Marseille, France.
authors.forename: Sarah
authors.initials: S
authors.lastname: Boukezzi
authors.affiliation: Department of Psychiatry, University Hospital of Saint-Etienne, Saint-Etienne, France; TAPE Laboratory, EA7423, Jean Monnet University, Saint-Etienne, France.
authors.forename: Aurélia
authors.initials: A
authors.lastname: Gay
authors.affiliation: Department of Psychiatry, University Hospital of Saint-Etienne, Saint-Etienne, France; TAPE Laboratory, EA7423, Jean Monnet University, Saint-Etienne, France.
authors.forename: Torrance
authors.initials: T
authors.lastname: Sigaud
authors.affiliation: Department of Psychiatry, University Hospital of Saint-Etienne, Saint-Etienne, France; TAPE Laboratory, EA7423, Jean Monnet University, Saint-Etienne, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Massoubre
authors.affiliation: Department of Psychiatry, University Hospital of Strasbourg, INSERM U1114, Strasbourg, France.
authors.forename: Fabrice
authors.initials: F
authors.lastname: Berna
authors.affiliation: Department of Psychiatry, La Conception University Hospital, Marseille, France.
authors.forename: Xavier Y
authors.initials: XY
authors.lastname: Zendjidjian
authors.affiliation: Timone Institute of Neuroscience, UMR 7289, CNRS and Aix-Marseille University, Marseille, France; Department of Psychiatry, Sainte Marguerite University Hospital, Marseille, France.
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Azorin
authors.affiliation: Timone Institute of Neuroscience, UMR 7289, CNRS and Aix-Marseille University, Marseille, France; Public Assistance for Marseille Hospitals (APHM) Unit for Clinical Pharmacology and Therapeutic Evaluation (CIC-UPCET), CHU Timone Hospital, Marseille, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Blin
authors.affiliation: Timone Institute of Neuroscience, UMR 7289, CNRS and Aix-Marseille University, Marseille, France; Department of Psychiatry, University Hospital of Saint-Etienne, Saint-Etienne, France; TAPE Laboratory, EA7423, Jean Monnet University, Saint-Etienne, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Fakra
mesh_terms: D000328:Adult; D054523:Adult Survivors of Child Abuse / Q000523:psychology; D000069586:Adult Survivors of Child Adverse Events / Q000523:psychology; D000679:Amygdala / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000503:physiopathology*; D063132:Connectome / Q000379:methods*; D004644:Emotions / Q000502:physiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010364:Pattern Recognition, Visual / Q000502:physiology; D012559:Schizophrenia / Q000503:physiopathology*; D055815:Young Adult
keywords: Amygdala; Childhood trauma; Posterior cingulate cortex; Precuneus; Schizophrenia; fMRI functional connectivity