title: Phospholipids in Autophagosome Formation and Fusion.
abstract: Autophagosomes are double membrane organelles that are formed during a process referred to as macroautophagy. They serve to deliver cytoplasmic material into the lysosome for degradation. Autophagosomes are formed in a de novo manner and are the result of substantial membrane remodeling processes involving numerous protein-lipid interactions. While most studies focus on the proteins involved in autophagosome formation it is obvious that lipids including phospholipids, sphingolipids and sterols play an equally important role. Here we summarize the current knowledge about the role of lipids, especially focusing on phospholipids and their interplay with the autophagic protein machinery during autophagosome formation and fusion.
authors.affiliation: Max F. Perutz Laboratories, University of Vienna, Dr Bohr-Gasse 9/3, 1030 Vienna, Austria. Electronic address: sascha.martens@univie.ac.at.
authors.forename: Sascha
authors.initials: S
authors.lastname: Martens
authors.affiliation: Department of Genetics, Graduate School of Medicine, Osaka University, Yamadaoka 2-2, Suita, Osaka, 565-0871, Japan.
authors.forename: Shuhei
authors.initials: S
authors.lastname: Nakamura
authors.affiliation: Department of Genetics, Graduate School of Medicine, Osaka University, Yamadaoka 2-2, Suita, Osaka, 565-0871, Japan. Electronic address: tamyoshi@fbs.osaka-u.ac.jp.
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Yoshimori
keywords: Autophagy; conjugation; lipid kinase; lipid phosphatase; lysosome; phosphatidylethanolamine; phosphatidylinositol 3-phosphate