title: Usefulness of non-fasting lipid parameters in children.
abstract: BACKGROUND
  This study assessed whether non-fasting lipid markers could be substituted for fasting markers in screening for dyslipidemia, whether direct measurement of non-fasting low-density lipoprotein cholesterol [LDL-C (D)] could be substituted for the calculation of fasting LDL-C [LDL-C (F)], and the utility of measuring non-high-density lipoprotein cholesterol (non-HDL-C).
  
  
  METHODS
  In 33 children, the lipid profile was measured in the non-fasting and fasting states within 24 h. Correlations were examined between non-fasting LDL-C (D) or non-HDL-C levels and fasting LDL-C (F) levels.
  
  
  RESULTS
  Non-fasting triglyceride (TG), total cholesterol (TC), HDL-C, LDL-C (D), and non-HDL-C levels were all significantly higher than the fasting levels, but the mean difference was within 10% (except for TG). Non-fasting LDL-C (D) and non-HDL-C levels were strongly correlated with the fasting LDL-C (F) levels.
  
  
  CONCLUSIONS
  In conclusion, except for TG, non-fasting lipid parameters are useful when screening children for dyslipidemia. Direct measurement of non-fasting LDL-C and calculation of non-fasting non-HDL-C could replace the calculation of fasting LDL-C because of convenience.
authors.forename: Toshihide
authors.initials: T
authors.lastname: Kubo
authors.forename: Kyohei
authors.initials: K
authors.lastname: Takahashi
authors.forename: Mahoko
authors.initials: M
authors.lastname: Furujo
authors.forename: Yuki
authors.initials: Y
authors.lastname: Hyodo
authors.forename: Hiroki
authors.initials: H
authors.lastname: Tsuchiya
authors.forename: Mariko
authors.initials: M
authors.lastname: Hattori
authors.forename: Shoko
authors.initials: S
authors.lastname: Fujinaga
authors.forename: Kenji
authors.initials: K
authors.lastname: Urayama
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D008076:Cholesterol, HDL / Q000032:analysis; D008078:Cholesterol, LDL / Q000032:analysis; D004392:Dwarfism / Q000503:physiopathology*; D050171:Dyslipidemias / Q000503:physiopathology*; D005215:Fasting / Q000502:physiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008055:Lipids / Q000032:analysis*; D008074:Lipoproteins / Q000032:analysis; D008297:Male; D011379:Prognosis; D011446:Prospective Studies; D014280:Triglycerides / Q000032:analysis
chemical_list: D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D008074:Lipoproteins; D014280:Triglycerides