title: Low circulating coenzyme Q10 during acute phase is associated with inflammation, malnutrition, and in-hospital mortality in patients admitted to the coronary care unit.
abstract: Coenzyme Q10 (CoQ10) has a potential role in the prevention and treatment of heart failure through improved cellular bioenergetics. In addition, it has antioxidant, free radical scavenging, and vasodilatory effects that may be beneficial. Although critical illness in intensive care unit is associated with decreased circulating CoQ10 levels, the clinical significance of CoQ10 levels during acute phase in the patients of cardiovascular disease remains unclear. We enrolled 257 consecutive cardiovascular patients admitted to the coronary care unit (CCU). Serum CoQ10 levels were measured after an overnight fast within 24 h of admission. We examined the comparison of serum CoQ10 levels between survivors and in-hospital mortalities in patients with cardiovascular disease. Serum CoQ10 levels during the acute phase in patients admitted to the CCU had similar independent of the diagnosis. CoQ10 levels were significantly lower in patients with in-hospital mortalities than in survivors (0.43 ± 0.19 vs. 0.55 ± 0.35 mg/L, P = 0.04). In patients admitted to the CCU, CoQ10 levels were negatively associated with age and C-reactive protein levels, and positively associated with body mass index, total cholesterol, and high-density lipoprotein cholesterol levels. Low CoQ10 levels correlated with low diastolic blood pressure. Multivariate logistic regression analysis demonstrated that low CoQ10 levels were an independent predictor of in-hospital mortality. Low serum CoQ10 levels during acute phase are significantly associated with cardiovascular risk and in-hospital mortality in patients admitted to the CCU.
authors.affiliation: Department of Cardiovascular Medicine, Juntendo University School of Medicine, 2-1-1Hongo Bunkyo-ku, Tokyo, 113-8421, Japan.
authors.forename: Megumi
authors.initials: M
authors.lastname: Shimizu
authors.affiliation: Department of Cardiovascular Medicine, Juntendo University School of Medicine, 2-1-1Hongo Bunkyo-ku, Tokyo, 113-8421, Japan. tetsuro@juntendo.ac.jp.
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Miyazaki
authors.affiliation: Department of Cardiovascular Medicine, Juntendo University School of Medicine, 2-1-1Hongo Bunkyo-ku, Tokyo, 113-8421, Japan.
authors.forename: Atsutoshi
authors.initials: A
authors.lastname: Takagi
authors.affiliation: Department of Cardiovascular Medicine, Juntendo University School of Medicine, 2-1-1Hongo Bunkyo-ku, Tokyo, 113-8421, Japan.
authors.forename: Yurina
authors.initials: Y
authors.lastname: Sugita
authors.affiliation: Department of Cardiovascular Medicine, Juntendo University School of Medicine, 2-1-1Hongo Bunkyo-ku, Tokyo, 113-8421, Japan.
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Yatsu
authors.affiliation: Department of Cardiovascular Medicine, Juntendo University School of Medicine, 2-1-1Hongo Bunkyo-ku, Tokyo, 113-8421, Japan.
authors.forename: Azusa
authors.initials: A
authors.lastname: Murata
authors.affiliation: Department of Cardiovascular Medicine, Juntendo University School of Medicine, 2-1-1Hongo Bunkyo-ku, Tokyo, 113-8421, Japan.
authors.forename: Takao
authors.initials: T
authors.lastname: Kato
authors.affiliation: Department of Cardiovascular Medicine, Juntendo University School of Medicine, 2-1-1Hongo Bunkyo-ku, Tokyo, 113-8421, Japan.
authors.forename: Shoko
authors.initials: S
authors.lastname: Suda
authors.affiliation: Department of Cardiovascular Medicine, Juntendo University School of Medicine, 2-1-1Hongo Bunkyo-ku, Tokyo, 113-8421, Japan.
authors.forename: Shohei
authors.initials: S
authors.lastname: Ouchi
authors.affiliation: Department of Cardiovascular Medicine, Juntendo University School of Medicine, 2-1-1Hongo Bunkyo-ku, Tokyo, 113-8421, Japan.
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Aikawa
authors.affiliation: Department of Cardiovascular Medicine, Juntendo University School of Medicine, 2-1-1Hongo Bunkyo-ku, Tokyo, 113-8421, Japan.
authors.forename: Masaru
authors.initials: M
authors.lastname: Hiki
authors.affiliation: Department of Cardiovascular Medicine, Juntendo University School of Medicine, 2-1-1Hongo Bunkyo-ku, Tokyo, 113-8421, Japan.
authors.forename: Shuhei
authors.initials: S
authors.lastname: Takahashi
authors.affiliation: Department of Cardiovascular Medicine, Juntendo University School of Medicine, 2-1-1Hongo Bunkyo-ku, Tokyo, 113-8421, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Hiki
authors.affiliation: Department of Cardiovascular Medicine, Juntendo University School of Medicine, 2-1-1Hongo Bunkyo-ku, Tokyo, 113-8421, Japan.
authors.forename: Hidemori
authors.initials: H
authors.lastname: Hayashi
authors.affiliation: Department of Cardiovascular Medicine, Juntendo University School of Medicine, 2-1-1Hongo Bunkyo-ku, Tokyo, 113-8421, Japan.
authors.forename: Takatoshi
authors.initials: T
authors.lastname: Kasai
authors.affiliation: Department of Cardiovascular Medicine, Juntendo University School of Medicine, 2-1-1Hongo Bunkyo-ku, Tokyo, 113-8421, Japan.
authors.forename: Kazunori
authors.initials: K
authors.lastname: Shimada
authors.affiliation: Department of Cardiovascular Medicine, Juntendo University School of Medicine, 2-1-1Hongo Bunkyo-ku, Tokyo, 113-8421, Japan.
authors.forename: Katsumi
authors.initials: K
authors.lastname: Miyauchi
authors.affiliation: Department of Cardiovascular Medicine, Juntendo University School of Medicine, 2-1-1Hongo Bunkyo-ku, Tokyo, 113-8421, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Daida
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D002318:Cardiovascular Diseases / Q000097:blood* / Q000401:mortality*; D003325:Coronary Care Units; D005260:Female; D017052:Hospital Mortality; D006760:Hospitalization; D006801:Humans; D007249:Inflammation / Q000097:blood*; D007564:Japan; D008075:Lipoproteins, HDL / Q000097:blood; D016015:Logistic Models; D008297:Male; D044342:Malnutrition / Q000097:blood*; D008875:Middle Aged; D015999:Multivariate Analysis; D012372:ROC Curve; D012307:Risk Factors; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D008075:Lipoproteins, HDL; D014451:Ubiquinone; D002097:C-Reactive Protein; C024989:coenzyme Q10
keywords: Aging; Coenzyme Q10; Coronary care unit; Inflammation; Malnutrition