title: Engineering of microcomplex of artemether and lumefantrine for effective drug treatment in malaria.
abstract: The objective of the present work was to engineer and characterize stable citric acid cross-linked microcomplex of the inclusion complexes of artemether with β-cyclodextrin and Kollidon VA 64®with lumefantrine to release the drugs in controlled manner for effective combinational drug treatment in malaria. The microcomplex had a hydrodynamic diameter of 1047 ± 147 nm with surface charge of -19.7 ± 0.5 mV. The microcomplex showed high encapsulation efficiencies 85.6 ± 1.78% for artemether and 91.16 ± 2.21% for lumefantrine due to the lipophilic nature of drugs. In-vitro and in-vivo drug release studies showed the controlled release of artemether and lumefantrine for a period of 24 h.
authors.affiliation: a Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management , SVKM's NMIMS University , Mumbai , India.
authors.forename: Pravin
authors.initials: P
authors.lastname: Shende
authors.affiliation: a Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management , SVKM's NMIMS University , Mumbai , India.
authors.forename: Prachi
authors.initials: P
authors.lastname: Desai
authors.affiliation: a Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management , SVKM's NMIMS University , Mumbai , India.
authors.forename: Ram S
authors.initials: RS
authors.lastname: Gaud
authors.affiliation: a Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management , SVKM's NMIMS University , Mumbai , India.
authors.forename: Rohan
authors.initials: R
authors.lastname: Dhumatkar
mesh_terms: D000962:Antimalarials / Q000737:chemistry* / Q000627:therapeutic use; D000077549:Artemether; D037621:Artemisinins / Q000737:chemistry* / Q000627:therapeutic use; D019343:Citric Acid / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D004347:Drug Interactions; D065546:Drug Liberation; D004983:Ethanolamines / Q000737:chemistry* / Q000627:therapeutic use; D005449:Fluorenes / Q000737:chemistry* / Q000627:therapeutic use; D000078102:Lumefantrine; D008288:Malaria / Q000188:drug therapy*; D008863:Microspheres; D010316:Particle Size; D011759:Pyrrolidines / Q000737:chemistry; D014753:Vinyl Compounds / Q000737:chemistry; D047392:beta-Cyclodextrins / Q000737:chemistry
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D004337:Drug Carriers; D004983:Ethanolamines; D005449:Fluorenes; D011759:Pyrrolidines; D014753:Vinyl Compounds; D047392:beta-Cyclodextrins; C402301:poly(vinylpyrrolidone-co-vinyl-acetate); D019343:Citric Acid; D000077549:Artemether; D000078102:Lumefantrine
keywords: Artemether; inclusion complex; lumefantrine; microcomplex