title: Evaluation and correlation of stress scores with blood pressure, endogenous cortisol levels, and homocysteine levels in patients with central serous chorioretinopathy and comparison with age-matched controls.
abstract: BACKGROUND
  Stress had been associated with the development of central serous chorioretinopathy (CSC). The study was designed to evaluate the effect of stress on other risk factors of CSC such as serum cortisol levels, serum homocysteine levels, and blood pressure (BP) in CSC patients.
  
  
  OBJECTIVE
  To compare stress scores, serum cortisol and serum homocysteine levels, and BP of CSC patients with that of control population and to correlate stress scores of CSC patients with BP, serum cortisol levels, and serum homocysteine levels.
  
  
  METHODS
  Stress scores, serum morning and evening cortisol levels, serum homocysteine levels, systolic and diastolic BP of 54 CSC patients were measured and compared with that of 54 age- and sex-related controls using Student's t-test. Stress scores of CSC patients were correlated with systolic and diastolic BP, serum morning and evening cortisol levels and serum homocysteine levels and Pearson correlation coefficient (r) were calculated.
  
  
  RESULTS
  Stress scores, serum homocysteine levels, serum morning and evening cortisol levels, and systolic and diastolic BP were all elevated in CSC patients as compared with age- and sex-related controls (P < 0.05). Stress scores of CSC patients were found to correlate strongly with serum homocysteine levels, serum morning and evening cortisol levels, and systolic and diastolic BP, with r values 0.82, 0.8, 0.8, 0.8, and 0.81, respectively (P < 0.0001).
  
  
  CONCLUSIONS
  Stress scores were elevated in CSC patients and were strongly correlated with serum homocysteine and cortisol levels and BP.
authors.affiliation: Department of Vitreo-retinal Services, Sri Jagdamba Charitable Eye Hospital, Sri Ganganagar, Rajasthan, India.
authors.forename: Abhishek
authors.initials: A
authors.lastname: Agarwal
authors.affiliation: Department of Vitreo-retinal Services, Sri Jagdamba Charitable Eye Hospital, Sri Ganganagar, Rajasthan, India.
authors.forename: Monika
authors.initials: M
authors.lastname: Garg
authors.affiliation: Department of Vitreo-retinal Services, Sri Jagdamba Charitable Eye Hospital, Sri Ganganagar, Rajasthan, India.
authors.forename: Nikhil
authors.initials: N
authors.lastname: Dixit
authors.affiliation: Department of Vitreo-retinal Services, Sri Jagdamba Charitable Eye Hospital, Sri Ganganagar, Rajasthan, India.
authors.forename: Rohini
authors.initials: R
authors.lastname: Godara
mesh_terms: D000328:Adult; D000367:Age Factors; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000502:physiology*; D056833:Central Serous Chorioretinopathy / Q000097:blood* / Q000209:etiology / Q000503:physiopathology; D002940:Circadian Rhythm; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013315:Stress, Psychological / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D055815:Young Adult
chemical_list: D015415:Biomarkers; D006710:Homocysteine; D006854:Hydrocortisone