title: Cytogenetic analysis in couples with recurrent miscarriages: a retrospective study from Punjab, north India.
abstract: Human reproduction is considered as the most inefficient event as ~15-20% of human pregnancies end in miscarriage and in the product of miscarriages, chromosomal anomalies are a common occurrence. The aim of the present retrospective study was to assess the frequency of chromosomal aberrations in couples with recurrent miscarriages in the region of Punjab and to compare with worldwide frequencies. In this study, a total of 440 cases were referred between the period 1995-2015. After lymphocyte culturing, giemsa-trypsin banding was done for each case to assess the chromosomal anomalies. The frequency of chromosomal aberrations among couples was found to be 3.41% in our study. Among these aberrations, balanced reciprocal translocations formed the largest group with 60% anomalies. We would conclude that clinicians should understand the importance of chromosomal analysis in these couples and refer them for karyotyping after two miscarriages to rule out the possible genetic cause of recurrent miscarriages.
authors.affiliation: Department of Human Genetics, Guru Nanak Dev University, Amritsar 143 005, India. anupamkaur@yahoo.com.
authors.forename: Neha
authors.initials: N
authors.lastname: Sudhir
authors.forename: Tajinder
authors.initials: T
authors.lastname: Kaur
authors.forename: Archana
authors.initials: A
authors.lastname: Beri
authors.forename: Anupam
authors.initials: A
authors.lastname: Kaur
mesh_terms: D000026:Abortion, Habitual / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D000328:Adult; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D020732:Cytogenetic Analysis; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D059785:Karyotype; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011247:Pregnancy; D012189:Retrospective Studies; D055815:Young Adult