title: A simply triggered peptide-based hydrogel as an injectable nanocarrier of tanshinone IIA and tanshinones.
abstract: An easily self-assembled and gelated octa-peptide FHFDFHFD was chosen as a novel drug delivery system (DDS) for both tanshinone IIA and total tanshinone extract. The DDS showed increased loading capacity, sustained drug release and better anticancer capability. Our research proved that a hydrogel DDS of other traditional Chinese medicines is possible.
authors.affiliation: Department of Analytical Chemistry, China Pharmaceutical University, Nanjing, China.
authors.forename: Yajun
authors.initials: Y
authors.lastname: Yin
authors.affiliation: Department of Analytical Chemistry, China Pharmaceutical University, Nanjing, China.
authors.forename: Can
authors.initials: C
authors.lastname: Wu
authors.affiliation: Department of Analytical Chemistry, China Pharmaceutical University, Nanjing, China.
authors.forename: Junling
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Analytical Chemistry, China Pharmaceutical University, Nanjing, China.
authors.forename: Fengjuan
authors.initials: F
authors.lastname: Song
authors.affiliation: Department of Analytical Chemistry, China Pharmaceutical University, Nanjing, China and Key Laboratory of Biomedical Functional Materials, China Pharmaceutical University, Nanjing 210009, P. R. China. yuewq@cpu.edu.cn wyzhong@cpu.edu.cn.
authors.forename: Wanqing
authors.initials: W
authors.lastname: Yue
authors.affiliation: Department of Analytical Chemistry, China Pharmaceutical University, Nanjing, China and Key Laboratory of Biomedical Functional Materials, China Pharmaceutical University, Nanjing 210009, P. R. China. yuewq@cpu.edu.cn wyzhong@cpu.edu.cn.
authors.forename: Wenying
authors.initials: W
authors.lastname: Zhong
mesh_terms: D000072283:A549 Cells; D045784:Abietanes / Q000008:administration & dosage* / Q000494:pharmacology; D000595:Amino Acid Sequence; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D003692:Delayed-Action Preparations / Q000737:chemistry*; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D007267:Injections; D008958:Models, Molecular; D049329:Nanostructures / Q000737:chemistry / Q000648:ultrastructure; D009369:Neoplasms / Q000188:drug therapy; D009842:Oligopeptides / Q000737:chemistry*
chemical_list: D045784:Abietanes; D000972:Antineoplastic Agents, Phytogenic; D003692:Delayed-Action Preparations; D009842:Oligopeptides; C021751:tanshinone; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate