title: Recurrence and survival factors analysis of 171 cases of sacral chordoma in a single institute.
abstract: To evaluate postoperative recurrence, survival and metastasis results and related factors of sacral chordoma.
  
  
  
  Between 1978 and 2013, a total of 171 patients with sacral chordoma were diagnosed at our institution and 162 cases underwent operation. The clinical characteristics, treatment and outcomes of all these patients were reviewed.
  
  
  
  The 3-year recurrence free survival rate was 83.1%. The median recurrence free survival time was 73 ± 7.8 months. Tumor level in sacrum and surgical margin were significant factors influencing recurrence. Recurrence was significant factor influencing metastasis. One hundred and fifty-seven cases were followed up for an average of 55.6 months. 135 cases (86%) survived, 37 cases (23.6%) developed recurrence, and 17 cases (10.8%) developed metastasis. The overall 5- and 10-year survival rate was 88.3% and 59.6%, respectively. Age (p = 0.037) and metastasis (p = 0.001) were significant factors influencing survival. The 3-year recurrence free survival rate was 80.1%. The median recurrence free survival time was 69 ± 12.7 months. Tumor level in sacrum (p = 0.035) and surgical margin (p = 0.009) were significant factors influencing recurrence. Seventeen cases (10.8%) had metastasis. Recurrence (p = 0.016) was significant factors influencing metastasis.
  
  
  
  Sacral chordoma tended to occur in elderly male patients and locate below sacral 3 level. The recurrence rate was high, especially for tumor above sacral 3 level. Wide surgical margin is very important for good local control. The patients with metastasis had poor prognosis.
authors.affiliation: Department of Orthopedic Oncology, Beijing Ji Shui Tan Hospital, Peking University, Beijing, People's Republic of China.
authors.forename: Yongkun
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Orthopedic Oncology, Beijing Ji Shui Tan Hospital, Peking University, Beijing, People's Republic of China. niuxiaohui@263.net.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Niu
authors.affiliation: Department of Orthopedic Oncology, Beijing Ji Shui Tan Hospital, Peking University, Beijing, People's Republic of China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Orthopedic Oncology, Beijing Ji Shui Tan Hospital, Peking University, Beijing, People's Republic of China.
authors.forename: Weifeng
authors.initials: W
authors.lastname: Liu
authors.affiliation: Department of Orthopedic Oncology, Beijing Ji Shui Tan Hospital, Peking University, Beijing, People's Republic of China.
authors.forename: Hairong
authors.initials: H
authors.lastname: Xu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002817:Chordoma / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D005163:Factor Analysis, Statistical; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D012189:Retrospective Studies; D012307:Risk Factors; D012447:Sacrum / Q000473:pathology / Q000601:surgery*; D013125:Spinal Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D016019:Survival Analysis
keywords: China; Metastasis; Recurrence; Sacral chordoma; Survival