title: Neutrophil migration in inflammation: intercellular signal relay and crosstalk.
abstract: Neutrophils are innate effector cells armed with a potent machinery to combat damage and infection within tissues. Their ability to rapidly respond to danger signals and mobilise is crucial to their role. After extravasation, neutrophil populations often exhibit swarming behaviour. Swarming occurs in distinct phases and is coordinated via inter-neutrophil signal relay in the form of small molecule mediators. Neutrophils also engage in multi-dimensional crosstalk with tissue-resident cells and incoming leukocytes in the inflammatory milieu. The complexity of neutrophil crosstalk with other innate immune cells mirrors that of the adaptive immune system, with rudimentary features of 'priming' and 'licensing'. We review recent findings relating to the migration and intercellular crosstalks of neutrophils in the initiation and resolution of inflammation.
authors.affiliation: Immune Imaging Program, Centenary Institute for Cancer Medicine and Cell Biology, Newtown, NSW 2042, Australia; The University of Sydney Medical School, NSW 2006, Australia. Electronic address: s.tan@centenary.org.au.
authors.forename: Sioh-Yang
authors.initials: SY
authors.lastname: Tan
authors.affiliation: Immune Imaging Program, Centenary Institute for Cancer Medicine and Cell Biology, Newtown, NSW 2042, Australia; The University of Sydney Medical School, NSW 2006, Australia; Department of Dermatology, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia. Electronic address: w.weninger@centenary.org.au.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Weninger
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D002465:Cell Movement; D060833:Cellular Microenvironment; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000276:immunology*; D009504:Neutrophils / Q000276:immunology*; D019899:Paracrine Communication; D015398:Signal Transduction