title: The effect of cortisol on autobiographical memory retrieval depends on remoteness and valence of memories.
abstract: There is evidence that specificity of autobiographical memory (AM) retrieval is impaired by cortisol. However, it is unknown whether glucocorticoids differentially influence the retrieval of recent versus remote AMs. Therefore, the aim of the current study was to investigate the effects of cortisol on AM retrieval, in terms of memory specificity, with respect to remoteness of the retrieved memories. A placebo controlled, double blind study was conducted. Thirty female and 24 male healthy participants (mean age 24.5, SD=3.7) received either placebo or 10mg hydrocortisone before completing an autobiographical memory test. Participants showed higher memory specificity for recent memories compared to remote ones. There was no main effect of cortisol on AM retrieval. However, interaction effects suggest that cortisol affects remote, but not recent memories, which seems to depend upon valence.
authors.affiliation: Department of Psychiatry, Charité University Berlin, Campus Benjamin Franklin, Berlin, Germany. Electronic address: juliane.fleischer@charite.de.
authors.forename: Juliane
authors.initials: J
authors.lastname: Fleischer
authors.affiliation: Department of Psychiatry, Charité University Berlin, Campus Benjamin Franklin, Berlin, Germany.
authors.forename: Juliane
authors.initials: J
authors.lastname: Weber
authors.affiliation: Department of Psychiatry, Charité University Berlin, Campus Benjamin Franklin, Berlin, Germany.
authors.forename: Julian
authors.initials: J
authors.lastname: Hellmann-Regen
authors.affiliation: Department of Psychiatry, Charité University Berlin, Campus Benjamin Franklin, Berlin, Germany.
authors.forename: Moritz
authors.initials: M
authors.lastname: Düsenberg
authors.affiliation: Department of Cognitive Psychology, Institute of Cognitive Neuroscience, Ruhr-University Bochum, Germany.
authors.forename: Oliver T
authors.initials: OT
authors.lastname: Wolf
authors.affiliation: Department of Psychiatry, Charité University Berlin, Campus Benjamin Franklin, Berlin, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Otte
authors.affiliation: Department of Psychiatry, Charité University Berlin, Campus Benjamin Franklin, Berlin, Germany.
authors.forename: Katja
authors.initials: K
authors.lastname: Wingenfeld
mesh_terms: D000328:Adult; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D061212:Memory, Episodic; D011939:Mental Recall / Q000187:drug effects*; D013997:Time Factors; D055815:Young Adult
chemical_list: D006854:Hydrocortisone
keywords: Autobiographical memory; Cortisol; Hippocampus; Remoteness; Valence