title: Estrogen Receptor β as a Pharmaceutical Target.
abstract: A major issue in clinical endocrinology today is how to use hormones to achieve the health benefits that they clearly can provide but avoid the negative side effects, that is, how to develop more precise medicines. This problem of how to use hormones is pervasive in clinical endocrinology. It is true for estrogen, progesterone, androgen, vitamin D, and thyroid hormone, and the problem is amplified in the case of new ligands for the more recently discovered nuclear receptors. Selective targeting of hormone receptor subtypes is one attractive way to harness the beneficial effects of hormones while reducing unwanted side effects. Here, we focus on estrogen receptor (ER)β, which has promise as a selective target in hormone replacement therapy, and in breast and prostate cancers.
authors.affiliation: Center for Nuclear Receptors and Cell Signaling, Department of Cell Biology and Biochemistry, University of Houston, Texas, USA.
authors.forename: Margaret
authors.initials: M
authors.lastname: Warner
authors.affiliation: Center for Nuclear Receptors and Cell Signaling, Department of Cell Biology and Biochemistry, University of Houston, Texas, USA.
authors.forename: Bo
authors.initials: B
authors.lastname: Huang
authors.affiliation: Center for Nuclear Receptors and Cell Signaling, Department of Cell Biology and Biochemistry, University of Houston, Texas, USA; Center for Innovative Medicine, Department of Biosciences and Nutrition, Novum, Karolinska Institutet, Huddinge, Sweden. Electronic address: jgustafs@Central.UH.EDU.
authors.forename: Jan-Ake
authors.initials: JA
authors.lastname: Gustafsson
mesh_terms: D001943:Breast Neoplasms / Q000737:chemistry / Q000188:drug therapy; D047629:Estrogen Receptor beta / Q000819:agonists / Q000187:drug effects* / Q000502:physiology; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D008024:Ligands; D008297:Male; D000072376:Oxysterols / Q000494:pharmacology; D057285:Precision Medicine; D011471:Prostatic Neoplasms / Q000737:chemistry / Q000188:drug therapy
chemical_list: D047629:Estrogen Receptor beta; D008024:Ligands; D000072376:Oxysterols