title: Nickel(II)-Catalyzed Cascade Vinylogous Mukaiyama 1,6-Michael/Michael Addition of 2-Silyloxyfuran with N-Sulfonyl-1-aza-1,3-dienes: Access to Fused Piperidine/Butyrolactone Skeletons.
abstract: An unprecedented and highly efficient nickel-catalyzed cascade vinylogous Mukaiyama 1,6-Michael/Michael addition of 2-silyloxyfuran with N-sulfonyl-1-aza-1,3-dienes is reported, in which 2-silyloxyfuran was successfully employed as nucleophile and electrophile sequentially. This methodology combined with subsequent reduction provides a facile access to biologically important fused piperidine/butyrolactone skeletons in good yield with exclusive diastereoselectivity under mild reaction conditions.
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University , Wuhan 430072, China.
authors.forename: Kang
authors.initials: K
authors.lastname: Liu
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University , Wuhan 430072, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Chang
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University , Wuhan 430072, China.|State Key Laboratory of Elemento-organic Chemistry, Nankai University , Tianjin, China 300071.
authors.forename: Chun-Jiang
authors.identifier: 0000-0003-3629-6889
authors.initials: CJ
authors.lastname: Wang