title: Blood Product Supply in Germany: The Impact of Apheresis and Pooled Platelet Concentrates.
abstract: BACKGROUND
  In Germany, about 60% of all produced platelet concentrates (PCs) are apheresis PCs (APCs). Ongoing discussions on APC reimbursement and costs might lead to a potential shift in pooled PC (PPC)/APC production. Objective of this analysis was to build a comprehensive model from the societal perspective to evaluate consequences associated with shifts in platelet supply and demand.
  
  
  METHODS
  Literature search, desktop researches on platelet supply and demand. Model calculations, time horizon one year: model input from the Paul-Ehrlich-Institute, data 2013. Base case: 19.2% of annual whole blood donations (WBDs) were used for production of 38.5% PPCs, decay of 46,218 PCs (8.0%). Scenarios calculated: variation in PPC proportion of 10-100%.
  
  
  RESULTS
  Base case: during PPC production 41,957-83,913 red blood cell concentrates (RBCCs) are estimated to be lost, which corresponds to 1-2% of annual RBCCs in Germany. Scenarios were calculated for a production of 60-100% PPCs: loss is estimated to be 1.5-5.0% of annual RBCCs (65,430-218,099), decay 54,189-69,022 PCs (9.4-12.0%).
  
  
  CONCLUSIONS
  Production of different blood components is interlinked and sensitive to unidimensional decisions. Increasing PPC proportion has negative impact on the RBCC production and on the antigen-matched APC donor pool. Completion of the model calculations to predict the optimal PPC/APC proportion would require evidence on the number of refractory patients, donor pool sizes, and incidences of diseases requiring platelet transfusions.
authors.affiliation: Department of Hematology/Oncology, University Hospital of Munich, Munich, Germany.
authors.forename: Karin
authors.initials: K
authors.lastname: Berger
authors.affiliation: Department of Hematology/Oncology, University Hospital of Munich, Munich, Germany.
authors.forename: Dorothee
authors.initials: D
authors.lastname: Schopohl
authors.affiliation: Department of Transfusion Medicine, Cell Therapeutics and Hemostaseology, University Hospital of Munich, Munich, Germany.
authors.forename: Georg
authors.initials: G
authors.lastname: Wittmann
authors.affiliation: University of Munich, Rudolf-Marx-Foundation, Munich, Germany.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Schramm
authors.affiliation: Department of Hematology/Oncology, University Hospital of Munich, Munich, Germany.
authors.forename: Helmut
authors.initials: H
authors.lastname: Ostermann
authors.affiliation: Department of Hematology/Oncology, University Hospital of Munich, Munich, Germany.
authors.forename: Christina
authors.initials: C
authors.lastname: Rieger
keywords: Antigen-matched platelets; Apheresis platelets; Donor pool; Pooled platelets; Red blood cell concentrates