title: Regioselective Copper-Catalyzed Boracarboxylation of Vinyl Arenes.
abstract: Regioselective copper-catalyzed boracarboxylation of vinyl arenes with bis(pinacolato)diboron and carbon dioxide has been achieved. New boron-functionalized α-aryl carboxylic acids, including nonsteroidal anti-inflammatory drugs (NSAIDs), are obtained in moderate to excellent yields. The synthetic utility of the transformation was shown through subsequent derivatization of the carbon-boron bond yielding formal hydroxy- and fluorocarboxylation products as well as anionic difluoroboralactones.
authors.affiliation: C. Eugene Bennett Department of Chemistry, West Virginia University , Morgantown, West Virginia 26505, United States.
authors.forename: Trevor W
authors.initials: TW
authors.lastname: Butcher
authors.affiliation: C. Eugene Bennett Department of Chemistry, West Virginia University , Morgantown, West Virginia 26505, United States.
authors.forename: Edward J
authors.initials: EJ
authors.lastname: McClain
authors.affiliation: C. Eugene Bennett Department of Chemistry, West Virginia University , Morgantown, West Virginia 26505, United States.
authors.forename: Tyler G
authors.initials: TG
authors.lastname: Hamilton
authors.affiliation: C. Eugene Bennett Department of Chemistry, West Virginia University , Morgantown, West Virginia 26505, United States.
authors.forename: Trina M
authors.initials: TM
authors.lastname: Perrone
authors.affiliation: C. Eugene Bennett Department of Chemistry, West Virginia University , Morgantown, West Virginia 26505, United States.
authors.forename: Kayla M
authors.initials: KM
authors.lastname: Kroner
authors.affiliation: C. Eugene Bennett Department of Chemistry, West Virginia University , Morgantown, West Virginia 26505, United States.
authors.forename: Gregory C
authors.initials: GC
authors.lastname: Donohoe
authors.affiliation: C. Eugene Bennett Department of Chemistry, West Virginia University , Morgantown, West Virginia 26505, United States.
authors.forename: Novruz G
authors.initials: NG
authors.lastname: Akhmedov
authors.affiliation: C. Eugene Bennett Department of Chemistry, West Virginia University , Morgantown, West Virginia 26505, United States.
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Petersen
authors.affiliation: C. Eugene Bennett Department of Chemistry, West Virginia University , Morgantown, West Virginia 26505, United States.
authors.forename: Brian V
authors.identifier: 0000-0001-6367-1168
authors.initials: BV
authors.lastname: Popp