title: Using Optimal Control to Disambiguate the Effect of Depression on Sensorimotor, Motivational and Goal-Setting Functions.
abstract: Differentiating the ability from the motivation to act is of central importance to psychiatric disorders in general and depression in particular. However, it has been difficult to develop quantitative approaches to relate depression to poor motor performance in goal-directed tasks. Here, we use an inverse optimal control approach to provide a computational framework that can be used to infer and factorize performance deficits into three components: sensorimotor speed, goal setting and motivation. Using a novel computer-simulated driving experiment, we found that (1) severity of depression is associated with both altered sensorimotor speed and motivational function; (2) moderately to severely depressed individuals show an increased distance from the stop sign indicating aversive learning affecting goal setting functions. Taken together, the inverse optimal control framework can disambiguate on an individual basis the sensorimotor from the motivational dysfunctions in depression, which may help to develop more precisely targeted interventions.
authors.affiliation: Department of Cognitive Science, UC San Diego, La Jolla, California.|Machine Perception Lab, UC San Diego, La Jolla, California.|Laureate Institute for Brain Research, Tulsa, Oklahoma.
authors.forename: He
authors.initials: H
authors.lastname: Huang
authors.affiliation: Department of Psychiatry, UC San Diego, La Jolla, California.
authors.forename: Katia
authors.initials: K
authors.lastname: Harlé
authors.affiliation: Machine Perception Lab, UC San Diego, La Jolla, California.
authors.forename: Javier
authors.initials: J
authors.lastname: Movellan
authors.affiliation: Laureate Institute for Brain Research, Tulsa, Oklahoma.|Department of Psychiatry, UC San Diego, La Jolla, California.
authors.forename: Martin
authors.initials: M
authors.lastname: Paulus
mesh_terms: D000293:Adolescent; D000328:Adult; D059445:Anhedonia; D003072:Cognition Disorders; D003198:Computer Simulation; D003863:Depression / Q000503:physiopathology / Q000628:therapy*; D005260:Female; D006040:Goals; D006801:Humans; D016014:Linear Models; D008297:Male; D009042:Motivation; D009048:Motor Skills; D011930:Reaction Time; D015203:Reproducibility of Results; D014584:User-Computer Interface; D055815:Young Adult