title: Antitumor Effects of Palladium-α-Lipoic Acid Complex Formulation as an Adjunct in Radiotherapy.
abstract: Several investigations have been initiated to enhance the antitumor effect of radiation and ameliorate its adverse effects such as reducing blood cell counts and causing DNA damage in normal cells. Compounds that enhance the antitumor activity of radiation without reducing blood cell counts or damaging DNA in normal cells can be of immense use as an adjunct in radiotherapy. We evaluated the antitumor effect of a specific set of minerals, vitamins, and amino acids (Poly-MVA) (2 mL/kg, per os), with and without radiation, against Dalton's lymphoma ascites (DLA) and Ehrlich's ascites carcinoma (EAC) cell lines that were transplanted in a solid-tumor model. Whole-body γ-radiation exposure (2 Gy) was performed using 60Co. Poly-MVA enhanced the antitumor effect of radiation when administered beforehand. Furthermore, Poly-MVA administered once daily for 2 wk, immediately after 4 Gy irradiation, protected DNA damage in peripheral blood. It also rendered protection against the radiation-induced reduction of platelet count. The unique electronic and redox properties of palladium-α-lipoic acid complex in Poly-MVA appear to be responsible for the exhibited effect. The results conclude that the antitumor-enhancing and normal cell-protective effect of Poly-MVA warrants additional studies for its potential clinical application.
authors.affiliation: Department of Microbiology, Amala Cancer Research Centre.
authors.forename: Ravindran Kalathil
authors.initials: RK
authors.lastname: Veena
authors.affiliation: Department of Biochemistry, Amala Institute of Medical Sciences, Thrissur-680 555, Kerala, India.
authors.forename: Thekkuttuparambil Ananthanarayanan
authors.initials: TA
authors.lastname: Ajith
authors.affiliation: Department of Microbiology, Amala Cancer Research Centre, Amala Nagar, Thrissur 680 555, Kerala, India.
authors.forename: Kainoor Krishnankutty
authors.initials: KK
authors.lastname: Janardhanan
authors.affiliation: Department of Biology, St. Joseph's College, Patchogue, NY; Garnett McKeen Laboratory, Inc., Bohemia, NY.
authors.forename: Francis
authors.initials: F
authors.lastname: Antonawich
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004249:DNA Damage / Q000187:drug effects; D005720:Gamma Rays; D008297:Male; D051379:Mice; D010165:Palladium / Q000494:pharmacology*; D011878:Radiotherapy / Q000379:methods*; D008063:Thioctic Acid / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D010165:Palladium; D008063:Thioctic Acid