title: Pazopanib: a novel treatment option for aggressive fibromatosis.
abstract: BACKGROUND
  Aggressive fibromatosis (AF), also known as desmoid tumor, is an uncommon soft tissue neoplasm. AF does not metastasize, but it is locally invasive and its propensity for recurrence after conservative resection is well documented. No effective cytotoxic treatment has been reported, hence there is a need for novel treatment strategies.
  
  
  METHODS
  We present the case of an AF successfully treated with an oral tyrosine kinase inhibitor, pazopanib, with mild side effects. As far as we know, this is the first case of AF with complete response to pazopanib.
  
  
  CONCLUSIONS
  Pazopanib might be an effective treatment option for AF.
authors.affiliation: Department of Medical Oncology, Ege University Medical School, Tulay Aktas Oncology Hospital, Ege University, Izmir, Turkey.
authors.forename: Gulcan
authors.identifier: 0000-0001-7382-0972
authors.initials: G
authors.lastname: Bulut
authors.affiliation: Department of Internal Medicine, Ege University Medical School, Ege University Medical School Hospital, Ege University, Izmir, Turkey.
authors.forename: Anil
authors.initials: A
authors.lastname: Ozluk
authors.affiliation: Department of Medical Oncology, Ege University Medical School, Tulay Aktas Oncology Hospital, Ege University, Izmir, Turkey.
authors.forename: Atike Pınar
authors.initials: AP
authors.lastname: Erdogan
authors.affiliation: Department of Medical Oncology, Ege University Medical School, Tulay Aktas Oncology Hospital, Ege University, Izmir, Turkey.
authors.forename: Ruchan
authors.initials: R
authors.lastname: Uslu
authors.affiliation: Department of Radiology, Ege University Medical School, Ege University Medical School Hospital, Ege University, Izmir, Turkey.
authors.forename: Nevra
authors.initials: N
authors.lastname: Elmas
authors.affiliation: Department of Medical Oncology, Ege University Medical School, Tulay Aktas Oncology Hospital, Ege University, Izmir, Turkey.
authors.forename: Burcak
authors.initials: B
authors.lastname: Karaca
keywords: Aggressive fibromatosis; Desmoid tumor; Oral tyrosine kinase inhibitor; Pazopanib