title: Exploring the chemopreventive properties and perspectives of baicalin and its aglycone baicalein in solid tumors.
abstract: Solid tumors contain a huge mass of malignant tumors other than hematological malignancies. Novel therapies based on bio-safe agents against solid tumors are urgently required. Baicalin and its aglycone baicalein, the major bioactive flavones derived from Scutellaria baicalensis, have potential roles in the management of cancer. The chemopreventive properties governed by baicalin and baicalein were multi-fold, via apoptosis induction, autophagy triggering, cell cycle arrest, inhibition of 12-lipoxygenase and metastasis suppression. However, their poor solubility and low oral bioavailability severely limited the clinical application. This extensive review focused on the promising anti-cancer activities of baicalin and baicalein and new techniques to improve their bioavailability.
authors.affiliation: The Department of Integrative Medicine, Huashan Hospital, Fudan University, 12 Middle Wulumiqi Road, Shanghai, PR China; The Institutes of Integrative Medicine of Fudan University, 12 Middle Wulumuqi Road, Shanghai, PR China.
authors.forename: Wei-Yi
authors.initials: WY
authors.lastname: Gong
authors.affiliation: The Department of Integrative Medicine, Huashan Hospital, Fudan University, 12 Middle Wulumiqi Road, Shanghai, PR China; The Institutes of Integrative Medicine of Fudan University, 12 Middle Wulumuqi Road, Shanghai, PR China.
authors.forename: Zheng-Xiao
authors.initials: ZX
authors.lastname: Zhao
authors.affiliation: The Department of Integrative Medicine, Huashan Hospital, Fudan University, 12 Middle Wulumiqi Road, Shanghai, PR China; The Institutes of Integrative Medicine of Fudan University, 12 Middle Wulumuqi Road, Shanghai, PR China.
authors.forename: Bao-Jun
authors.initials: BJ
authors.lastname: Liu
authors.affiliation: The Department of Integrative Medicine, Huashan Hospital, Fudan University, 12 Middle Wulumiqi Road, Shanghai, PR China; The Institutes of Integrative Medicine of Fudan University, 12 Middle Wulumuqi Road, Shanghai, PR China.
authors.forename: Lin-Wei
authors.initials: LW
authors.lastname: Lu
authors.affiliation: The Department of Integrative Medicine, Huashan Hospital, Fudan University, 12 Middle Wulumiqi Road, Shanghai, PR China; The Institutes of Integrative Medicine of Fudan University, 12 Middle Wulumuqi Road, Shanghai, PR China. Electronic address: jcdong2004@126.com.
authors.forename: Jing-Cheng
authors.initials: JC
authors.lastname: Dong
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D001682:Biological Availability; D018890:Chemoprevention / Q000379:methods*; D044950:Flavanones / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D005419:Flavonoids / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D006801:Humans; D009369:Neoplasms / Q000201:enzymology / Q000473:pathology / Q000517:prevention & control*
chemical_list: D016588:Anticarcinogenic Agents; D044950:Flavanones; D005419:Flavonoids; C038044:baicalin; C006680:baicalein
keywords: Baicalein; Baicalin; Bioavailability; Solid tumor