title: [A randomized controlled trial of preoperative oral immunonutrition in patients undergoing surgery for colorectal cancer: hospital stay and health care costs].
abstract: BACKGROUND
  The use of enteral formulas with immunonutrients in patients with gastrointestinal malignancies susceptible to surgery can reduce postoperative morbidity, at the expense of reduced infectious complications, with the consequent reduction in hospital stay and health care costs.
  
  
  METHODS
  Prospective randomized study. 84 patients operated on a scheduled basis for resectable colorectal cancer were recruited. In the group YES IN Impact © Oral was administered for 8 days (3 sachets a day), compared with the NOT IN group who did not receive it.
  
  
  RESULTS
  40.5% (17) patients without immunonutrition suffered infectious complications vs. 33.3% (14) of YES IN. In patients with rectal cancer NOT IN, 50% (8) suffered minor infectious complications (p=.028). In each group (YES IN, NOT IN, colon and rectal cancer) when infectious complications were observed, the variables total hospital stay and costs doubled, with significant differences. These variables showed higher values in the group NOT IN compared with those who received immunonutrition, although these differences were not statistically significant.
  
  
  CONCLUSIONS
  NOT IN patients suffered infectious complications more frequently than YES IN, with significant results in the subgroup of patients with rectal cancer. The total hospital stay and costs were slightly higher in the group not supplemented, doubling in each category significantly (YES IN, NOT IN, colon and rectal cancer), when infectious complications were observed.
authors.affiliation: Servicio de Cirugía General, Hospital General Universitario de Ciudad Real, Ciudad Real, España. Electronic address: carmenmc2010@gmail.com.
authors.forename: María Del Carmen
authors.initials: MDC
authors.lastname: Manzanares Campillo
authors.affiliation: Servicio de Cirugía General, Hospital General Universitario de Ciudad Real, Ciudad Real, España.
authors.forename: Jesús
authors.initials: J
authors.lastname: Martín Fernández
authors.affiliation: Departamento de Matemáticas, Facultad de Medicina de Ciudad Real, Universidad de Castilla la Mancha, Ciudad Real, España.
authors.forename: Mariano
authors.initials: M
authors.lastname: Amo Salas
authors.affiliation: Departamento de Ciencias Médicas y Quirúrgicas, Universidad de Cantabria, Santander, España.
authors.forename: Daniel
authors.initials: D
authors.lastname: Casanova Rituerto
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000191:economics / Q000276:immunology / Q000601:surgery*; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000150:complications / Q000191:economics / Q000276:immunology / Q000601:surgery*; D004044:Dietary Proteins / Q000008:administration & dosage; D004750:Enteral Nutrition / Q000191:economics; D005260:Female; D017048:Health Care Costs / Q000706:statistics & numerical data*; D006801:Humans; D007902:Length of Stay / Q000191:economics / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control; D011300:Preoperative Care / Q000191:economics / Q000379:methods*; D011446:Prospective Studies; D011502:Protein-Energy Malnutrition / Q000150:complications / Q000178:diet therapy
chemical_list: D004044:Dietary Proteins
keywords: Colorectal cancer; Complicaciones infecciosas; Cáncer colorrectal; Immunonutrition; Infectious complications; Inmunonutrición