title: Paclitaxel-Paclitaxel Prodrug Nanoassembly as a Versatile Nanoplatform for Combinational Cancer Therapy.
abstract: Recently, nanomedicine without drug carriers has attracted many pharmacists' attention. A novel paclitaxel-s-s-paclitaxel (PTX-s-s-PTX) conjugate with high drug loading (∼78%, w/w) was synthesized by conjugating paclitaxel to paclitaxel by using disulfide linkage. The conjugate could self-assemble into uniform nanoparticles (NPs) with 1,1-dioctadecyl-3,3,3,3-tetramethylindotricarbocyanine iodide (DiR) encapsulated within the core of PTX-s-s-PTX NPs for photothermal therapy (PTT). The DiR-loaded self-assembled nanoparticles (DSNs) had a mean diameter of about 150 nm and high stability in biological condition. A disulfide bond is utilized as a redox-responsive linkage to facilitate a rapid release of paclitaxel in tumor cells. DSNs indicated significant cytotoxicity as a result of the synergetic chemo-thermal therapy. DSNs were featured with excellent advantages, including high drug loading, redox-responsive releasing behavior of paclitaxel, capability of loading with photothermal agents, and combinational therapy with PTT. In such a potent nanosystem, prodrug and photothermal strategy are integrated into one system to facilitate the therapy efficiency.
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University , Shenyang 110016, China.
authors.forename: Xiangfei
authors.initials: X
authors.lastname: Han
authors.affiliation: Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University , Shenyang 110016, China.
authors.forename: Jinling
authors.initials: J
authors.lastname: Chen
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University , Shenyang 110016, China.
authors.forename: Mengjuan
authors.initials: M
authors.lastname: Jiang
authors.affiliation: Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University , Shenyang 110016, China.
authors.forename: Na
authors.initials: N
authors.lastname: Zhang
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University , Shenyang 110016, China.
authors.forename: Kexin
authors.initials: K
authors.lastname: Na
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University , Shenyang 110016, China.
authors.forename: Cong
authors.initials: C
authors.lastname: Luo
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University , Shenyang 110016, China.
authors.forename: Ruoshi
authors.initials: R
authors.lastname: Zhang
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University , Shenyang 110016, China.
authors.forename: Mengchi
authors.initials: M
authors.lastname: Sun
authors.affiliation: School of Pharmacy, Shandong University , Jinan 250012, China.
authors.forename: Guimei
authors.initials: G
authors.lastname: Lin
authors.affiliation: School of Pharmacy, Guangdong Pharmaceutical University , Guangzhou 510006, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Zhang
authors.affiliation: School of Chinese Materia Medica, Guangzhou University of Chinese Medicine , Guangzhou 510405, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University , Shenyang 110016, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Liu
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University , Shenyang 110016, China.
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic; D045744:Cell Line, Tumor; D004337:Drug Carriers; D006801:Humans; D050997:Nanomedicine; D053758:Nanoparticles; D009369:Neoplasms; D017239:Paclitaxel; D011355:Prodrugs
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004337:Drug Carriers; D011355:Prodrugs; D017239:Paclitaxel
keywords: anticancer; disulfide; high drug loading; photothermal therapy; redox responsive