title: Chiral Rhodium(III) Complex-Catalyzed Cascade Michael-Alkylation Reactions: Enantioselective Synthesis of Cyclopropanes.
abstract: Chiral Rh(III) complex catalyzed highly efficient enantioselective cyclopropanation of α,β-unsaturated 2-acyl imidazoles or pyridine with 2-bromomalonate is developed to generate corresponding multisubstituted cyclopropanes in 70-99% yields with 93→99% enantioselectivity. The proficiency of the process is also demonstrated in gram scale reaction maintaining same reactivity and selectivity level in lower catalyst loading. Moreover, the developed methodology is applicable in challenging synthesis of biscyclopropane scaffold with 97% ee in a single operation.
authors.affiliation: Key Laboratory of Coal to Ethylene Glycol and Its Related Technology, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences , 155 Yangqiao Road West, Fuzhou 350002, China.
authors.forename: Gui-Jun
authors.initials: GJ
authors.lastname: Sun
authors.affiliation: Key Laboratory of Coal to Ethylene Glycol and Its Related Technology, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences , 155 Yangqiao Road West, Fuzhou 350002, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Gong
authors.affiliation: Key Laboratory of Coal to Ethylene Glycol and Its Related Technology, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences , 155 Yangqiao Road West, Fuzhou 350002, China.
authors.forename: Qiang
authors.identifier: 0000-0002-9939-0875
authors.initials: Q
authors.lastname: Kang