title: FDG-PET-positive ovarian thecoma with GLUT5 expression: Five cases.
abstract: Positron emission tomography (PET) with fluorodeoxyglucose F18 (18F-FDG) is useful for detecting malignancies, but benign lesions occasionally have false-positive18F-FDG uptake. Here, we report the cases of five postmenopausal women with solid ovarian tumors suspected to be ovarian cancer on magnetic resonance imaging and18F-FDG uptake. Mean age of the five patients was 57 years (range, 53-65 years). Average early standardized uptake value (SUV) of18F-FDG was 5.76 (range, 2.2-12.0) and delayed SUV was 6.56 (range, 2.4-13.8). In all five patients, frozen section diagnosis at surgery was thecoma, and bilateral salpingo-oophorectomy was performed. On immunohistochemistry, immunoreactive glucose transporter 5 (GLUT5) expression was detected in thecoma tissues. This case shows that thecoma sometimes has positive18F-FDG uptake on positron emission tomography-computed tomography (PET-CT), indicating the need for caution regarding false-positive PET-CT in patients with benign solid ovarian tumor.
authors.affiliation: Department of Obstetrics and Gynecology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan.
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Bono
authors.affiliation: Department of Obstetrics and Gynecology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan.
authors.forename: Yasunari
authors.initials: Y
authors.lastname: Mizumoto
authors.affiliation: Department of Obstetrics and Gynecology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan.
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Nakamura
authors.affiliation: Department of Obstetrics and Gynecology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan.
authors.forename: Jyunpei
authors.initials: J
authors.lastname: Iwadare
authors.affiliation: Department of Obstetrics and Gynecology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Obata
authors.affiliation: Department of Obstetrics and Gynecology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Fujiwara
mesh_terms: D000368:Aged; D005189:False Positive Reactions; D005260:Female; D019788:Fluorodeoxyglucose F18; D051296:Glucose Transporter Type 5 / Q000378:metabolism*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000473:pathology; D000072078:Positron Emission Tomography Computed Tomography; D017698:Postmenopause; D013798:Thecoma / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000473:pathology
chemical_list: D051296:Glucose Transporter Type 5; C495726:SLC2A5 protein, human; D019788:Fluorodeoxyglucose F18
keywords: glucose transporter 5; positron emission tomography-computed tomography; thecoma