title: SAPHO syndrome in childhood. A case report.
abstract: The acronym of SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis and osteitis) combines a cluster of cutaneous and musculoskeletal manifestations, such as hyperostosis of bones of the anterior chest wall associated with acne fulminans and hidradenitis suppurativa. There are no validated diagnostic criteria in children. Nonsteroidal anti-inflammatory drugs are not always sufficient, and the use of corticosteroids, disease-modifying agents, tumor necrosis factor-α inhibitors or bisphosphonates may be necessary. We present the case of a child with polyarticular involvement, osteoarthritis of the sternoclavicular joint with severe inflammatory disorders and acne conglobata, with an excellent response to intravenous pamidronate.
authors.affiliation: Unidad de Gestión Clínica de Pediatría, Hospital Universitario San Cecilio, Granada, España. Electronic address: vargasperezm@gmail.com.
authors.forename: Manuel
authors.initials: M
authors.lastname: Vargas Pérez
authors.affiliation: Unidad de Gestión Clínica de Pediatría, Hospital Universitario San Cecilio, Granada, España.
authors.forename: Belén
authors.initials: B
authors.lastname: Sevilla Pérez
mesh_terms: D020083:Acquired Hyperostosis Syndrome / Q000175:diagnosis* / Q000188:drug therapy; D000293:Adolescent; D050071:Bone Density Conservation Agents / Q000627:therapeutic use; D004164:Diphosphonates / Q000627:therapeutic use; D006801:Humans; D008297:Male; D000077268:Pamidronate
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D000077268:Pamidronate
keywords: Acne; Acné; Bifosfonatos; Bisphosphonates; Hiperostosis; Hyperostosis; SAPHO syndrome; Síndrome SAPHO