title: Epidemiological Survey of Hepatitis C Virus Infection in Fife, Scotland.
abstract: BACKGROUND
  HCV infection is of growing public health importance in Scotland. We aim to establish: patient demographics; risk category; year/country of probable infection; referral/follow-up status; and genotypic variance of HCV in Fife.
  
  
  METHODS
  Details of all HCV antibody positive patients, referred and assessed at specialist clinics in NHS Fife, until 1st of May 2007 were obtained retrospectively from the Fife hepatitis C database.
  
  
  RESULTS
  In these patients, the ratio of males: female was 2:1, mean age was 36 years, representing a relatively young population, 27.4% of the patients consumed alcohol and 52.4% were smokers. Twelve patients were HIV/HCV co-infected (3.3%). Among the patients, 6.8% had serological evidence of past HBV exposure, 0.5% of patients were HCV/HBV co-infected and 18.8% were vaccinated. Eighty-six percent acquired HCV through injecting drug use and most cases were relatively newly acquired. Referral numbers were on the increase. Thirty-three of patients were under follow-up. Sixty-five percent of patients were genotype 2/3 and 35% were Genotype 1.
  
  
  CONCLUSIONS
  Clear patterns were observed in terms of age group, gender, geographical distribution and risk category to facilitate the effective targeting of resources. HCV population in Fife are relatively young, have acquired HCV recently and are mostly of genotype 2/3. This may have a favourable influence on disease progression and cost implications of treating HCV in Fife.
authors.affiliation: Infectious Diseases Unit, Victoria Hospital (NHS Fife), Kirkcaldy, Fife, United Kingdom, KY2 5AH, UK.
authors.forename: Lukman
authors.initials: L
authors.lastname: Hakeem
authors.affiliation: Infectious Diseases Unit, Victoria Hospital (NHS Fife), Kirkcaldy, Fife, United Kingdom, KY2 5AH, UK.
authors.forename: Grace A
authors.initials: GA
authors.lastname: Thomson
authors.affiliation: Infectious Diseases Unit, Victoria Hospital (NHS Fife), Kirkcaldy, Fife, United Kingdom, KY2 5AH, UK.
authors.forename: Diptendu N
authors.initials: DN
authors.lastname: Bhattacharyya
keywords: Epidemiological survey; Genotype; Hepatitis C; Injecting drug use; Sustained viral response