title: Parent-Reported Improvements in Family Functioning in a Randomized Controlled Trial of Lisdexamfetamine for Treatment of Parental Attention-Deficit/Hyperactivity Disorder.
abstract: OBJECTIVE
  This study examines the effects of parental stimulant medication treatment on parent ratings of parent-child functioning. Ratings of parent-child functioning in the home setting and immediately following a laboratory-based parent-child interaction were collected.
  
  
  METHODS
  Participants were 20 parents who along with their children (ages 5-12 years) were diagnosed with Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) attention-deficit/hyperactivity disorder (ADHD). Parents completed an open-label titration to determine their optimal dose of lisdexamfetamine (30, 50, or 70 mg/day) and then completed a month-long double-blind randomized pharmacological intervention for parental ADHD. Effects of parental stimulant medication administered for an extended duration were assessed by parent ratings of parent-child functioning in the home setting and immediately following a laboratory parent-child interaction task conducted at an academic mental health center. Data were collected from September 2010 to June 2013.
  
  
  RESULTS
  Stimulant medication versus placebo was associated with larger reductions in parental ADHD (d = 1.01-1.09), impairment (d = 0.67-0.82), and executive dysfunction (d = 0.74-0.94) in the home setting. No significant benefits of stimulant medication emerged in measures of parenting or child behavior at home. In the laboratory setting, parents treated with stimulant medication versus placebo reported fewer ADHD symptoms (d = 1.01-1.05) and their interaction was more successful (d = 0.83) and pleasant (d = 0.92). Several additional trends emerged showing beneficial effects of stimulant medication on parent-child functioning.
  
  
  CONCLUSIONS
  Parents treated with stimulant medication evidenced some improvements in parent-child functioning, which support the use of pharmacological intervention to improve functioning in families with parent-child ADHD.
  
  
  BACKGROUND
  NCT01127607.
authors.affiliation: 1 Penn State College of Medicine , Hershey, Pennsylvania.
authors.forename: Dara E
authors.initials: DE
authors.lastname: Babinski
authors.affiliation: 1 Penn State College of Medicine , Hershey, Pennsylvania.|2 Center for Children and Families, Florida International University , Miami, Florida.
authors.forename: James G
authors.initials: JG
authors.lastname: Waxmonsky
authors.affiliation: 1 Penn State College of Medicine , Hershey, Pennsylvania.
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Waschbusch
authors.affiliation: 2 Center for Children and Families, Florida International University , Miami, Florida.
authors.forename: Hugh
authors.initials: H
authors.lastname: Humphery
authors.affiliation: 2 Center for Children and Families, Florida International University , Miami, Florida.
authors.forename: William E
authors.initials: WE
authors.lastname: Pelham
mesh_terms: D000328:Adult; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy* / Q000523:psychology*; D000697:Central Nervous System Stimulants / Q000627:therapeutic use*; D002648:Child; D003692:Delayed-Action Preparations; D039721:Diagnostic and Statistical Manual of Mental Disorders; D004311:Double-Blind Method; D056344:Executive Function; D005260:Female; D006801:Humans; D007398:Interpersonal Relations; D000069478:Lisdexamfetamine Dimesylate / Q000627:therapeutic use*; D008297:Male; D010287:Parent-Child Relations; D016487:Parenting / Q000523:psychology*; D010290:Parents / Q000523:psychology*; D011569:Psychiatric Status Rating Scales; D011795:Surveys and Questionnaires
chemical_list: D000697:Central Nervous System Stimulants; D003692:Delayed-Action Preparations; D000069478:Lisdexamfetamine Dimesylate
keywords: attention-deficit/hyperactivity disorder; parenting; parent–child; stimulants