title: The Safety Limits Of An Extended Fast: Lessons from a Non-Model Organism.
abstract: While safety of fasting therapy is debated in humans, extended fasting occurs routinely and safely in wild animals. To do so, food deprived animals like breeding penguins anticipate the critical limit of fasting by resuming feeding. To date, however, no molecular indices of the physiological state that links spontaneous refeeding behaviour with fasting limits had been identified. Blood proteomics and physiological data reveal here that fasting-induced body protein depletion is not unsafe "per se". Indeed, incubating penguins only abandon their chick/egg to refeed when this state is associated with metabolic defects in glucose homeostasis/fatty acid utilization, insulin production and action, and possible renal dysfunctions. Our data illustrate how the field investigation of "exotic" models can be a unique source of information, with possible biomedical interest.
authors.affiliation: CNRS, UMR7178, 67037 Strasbourg, France.|Université de Strasbourg, IPHC, Laboratoire de Spectrométrie de Masse Bio-Organique, 25 rue Becquerel, 67087 Strasbourg, France.
authors.forename: Fabrice
authors.initials: F
authors.lastname: Bertile
authors.affiliation: CNRS, UMR7178, 67037 Strasbourg, France.|Université de Strasbourg, IPHC, Laboratoire de Spectrométrie de Masse Bio-Organique, 25 rue Becquerel, 67087 Strasbourg, France.
authors.forename: Laetitia
authors.initials: L
authors.lastname: Fouillen
authors.affiliation: CNRS, UMR7178, 67037 Strasbourg, France.|Université de Strasbourg, IPHC, Laboratoire de Spectrométrie de Masse Bio-Organique, 25 rue Becquerel, 67087 Strasbourg, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: Wasselin
authors.affiliation: CNRS, UMR7178, 67037 Strasbourg, France.|Université de Strasbourg, IPHC, Laboratoire de Spectrométrie de Masse Bio-Organique, 25 rue Becquerel, 67087 Strasbourg, France.
authors.forename: Pauline
authors.initials: P
authors.lastname: Maes
authors.affiliation: CNRS, UMR7178, 67037 Strasbourg, France.|Université de Strasbourg, IPHC, Département Ecologie, Physiologie et Ethologie, 23 rue Becquerel, 67087 Strasbourg, France.
authors.forename: Yvon
authors.initials: Y
authors.lastname: Le Maho
authors.affiliation: CNRS, UMR7178, 67037 Strasbourg, France.|Université de Strasbourg, IPHC, Laboratoire de Spectrométrie de Masse Bio-Organique, 25 rue Becquerel, 67087 Strasbourg, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Van Dorsselaer
authors.affiliation: CNRS, UMR7178, 67037 Strasbourg, France.|Université de Strasbourg, IPHC, Département Ecologie, Physiologie et Ethologie, 23 rue Becquerel, 67087 Strasbourg, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: Raclot
mesh_terms: D000818:Animals; D001798:Blood Proteins / Q000378:metabolism*; D005215:Fasting / Q000097:blood*; D006801:Humans; D012449:Safety; D046429:Spheniscidae / Q000097:blood*
chemical_list: D001798:Blood Proteins