title: Polycyclic aromatic hydrocarbons and PAH-related DNA adducts.
abstract: Investigations on the impact of chemicals on the environment and human health have led to the development of an exposome concept. The exposome refers to the totality of exposures received by a person during life, including exposures to life-style factors, from the prenatal period to death. The exposure to genotoxic chemicals and their reactive metabolites can induce chemical modifications of DNA, such as, for example, DNA adducts, which have been extensively studied and which play a key role in chemically induced carcinogenesis. Development of different methods for the identification of DNA adducts has led to adopting DNA adductomic approaches. The ability to simultaneously detect multiple PAH-derived DNA adducts may allow for the improved assessment of exposure, and offer a mechanistic insight into the carcinogenic process following exposure to PAH mixtures. The major advantage of measuring chemical-specific DNA adducts is the assessment of a biologically effective dose. This review provides information about the occurrence of the polycyclic aromatic hydrocarbons (PAHs) and their influence on human exposure and biological effects, including PAH-derived DNA adduct formation and repair processes. Selected methods used for determination of DNA adducts have been presented.
authors.affiliation: Institute for Ecology of Industrial Areas, Environmental Toxicology Group, 6, Kossutha Street, 40-844, Katowice, Poland. blaszczyk@ietu.katowice.pl.
authors.forename: Błaszczyk
authors.initials: B
authors.lastname: Ewa
authors.affiliation: Witold Pilecki State School of Higher Education, 8, Maksymiliana Kolbego Street, 32-600, Oświęcim, Poland.
authors.forename: Mielżyńska-Švach
authors.initials: MŠ
authors.lastname: Danuta
mesh_terms: D001711:Biotransformation; D018736:DNA Adducts / Q000235:genetics* / Q000378:metabolism; D004249:DNA Damage; D004260:DNA Repair; D004781:Environmental Exposure / Q000009:adverse effects*; D006801:Humans; D011084:Polycyclic Aromatic Hydrocarbons / Q000378:metabolism
chemical_list: D018736:DNA Adducts; D011084:Polycyclic Aromatic Hydrocarbons; C095911:polycyclic aromatic hydrocarbons-DNA adduct
keywords: Benzo[a]pyrene; DNA damage; PAH–DNA adducts; Polycyclic aromatic hydrocarbons