title: The expanding microRNA world in psoriasis.
abstract: Psoriasis skin lesions are characterized by dramatic changes in the transcriptome, reflecting altered activity of multiple signalling pathways in resident and infiltrating cells. miRNAs are small non-coding RNAs that have a large impact on cellular functions by regulating multiple genes simultaneously, and they have been shown to play key roles in skin homoeostasis and inflammation. In this commentary to the review article "MicroRNAs in Psoriasis: Immunological Functions and Potential Biomarkers" by Liu et al., the role of miRNAs in psoriasis and their diagnostic and therapeutic potential are discussed and remaining unanswered questions are highlighted.
authors.affiliation: Dermatology and Venereology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.|Unit of Dermatology, Karolinska University Hospital, Stockholm, Sweden.
authors.forename: Enikö
authors.initials: E
authors.lastname: Sonkoly
mesh_terms: D000818:Animals; D015415:Biomarkers; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D011565:Psoriasis / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism
chemical_list: D015415:Biomarkers; D035683:MicroRNAs
keywords: biomarker; microRNA; non-coding RNA; psoriasis; skin