title: Predictive and prognostic factors for patients with locoregionally advanced laryngeal carcinoma treated with surgical multimodality protocol.
abstract: The prognosis is suboptimal in patients with locoregionally advanced laryngeal carcinoma even after multimodality protocols. The purpose of this study was to determine the potential influential factors that have an impact on the development of locoregional recurrence, distant metastasis, and oncological outcomes in patients with locoregionally advanced laryngeal carcinoma who had surgical multimodality protocols. A sample size of 85 cases was determined based on a power of 90% and an effect size of α2= 0.05. A retrospective analysis of 357 patients with a diagnosis of laryngeal cancer between 2002 and 2015 was performed. Eighteen variables based on sociodemographic, clinical, histopathological and treatment data were analyzed. Medical records of 85 consecutive patients with locoregionally advanced laryngeal carcinoma who underwent surgical multimodality protocols were reviewed. Five-year overall, disease-specific, disease-free, locoregional recurrence-free and distant metastasis-free survival were 68.7, 78.0, 69.6, 68.9 and 69.2%, respectively. Extracapsular extension was an independent predictive factor for locoregional recurrence. Pathologic tumor volume was an independent predictive factor for distant metastasis. pT-stage was an independent prognostic factor for 5-year overall survival, disease-free survival, locoregional recurrence-free survival and distant metastasis-free survival. High volume, pT4a laryngeal tumors with extracapsular extension are associated with a high risk of locoregional recurrence and distant metastasis; and have poor oncological outcomes in patients with locoregionally advanced laryngeal carcinoma treated with surgical multimodality protocols.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Celal Bayar University, Manisa, Turkey.
authors.forename: Gorkem
authors.initials: G
authors.lastname: Eskiizmir
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Haydarpasa Numune Training and Research Hospital, 34668, Uskudar, Istanbul, Turkey. gokce.tanyeri@gmail.com.
authors.forename: Gokce
authors.initials: G
authors.lastname: Tanyeri Toker
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Celal Bayar University, Manisa, Turkey.
authors.forename: Onur
authors.initials: O
authors.lastname: Celik
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Celal Bayar University, Manisa, Turkey.
authors.forename: Kivanc
authors.initials: K
authors.lastname: Gunhan
authors.affiliation: Department of Pathology, Celal Bayar University, Manisa, Turkey.
authors.forename: Ayca
authors.initials: A
authors.lastname: Tan
authors.affiliation: Department of Biostatistics and Medical Informatics, Institute of Oncology, Dokuz Eylul University, Izmir, Turkey.
authors.forename: Hulya
authors.initials: H
authors.lastname: Ellidokuz
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000175:diagnosis* / Q000401:mortality / Q000601:surgery*; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality; D011379:Prognosis; D012189:Retrospective Studies
keywords: Adjuvant chemoradiotherapy; Laryngeal neoplasms; Laryngectomy; Neoplasm recurrence, local; Prognosis; Survival