title: Hippo Wades into Cancer Immunology.
abstract: The Hippo pathway limits organ size and suppresses tumors. Reporting in Cell, Moroishi et al. (2016), show that, paradoxically, Hippo pathway inactivation can repress tumor growth by modulating tumor immunogenicity. This could explain the rarity of pathway mutations in cancers and suggests Hippo pathway repression as a cancer immunotherapy modality.
authors.affiliation: Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, VIC 3000, Australia. Electronic address: gebhardt@unimelb.edu.au.
authors.forename: Thomas
authors.initials: T
authors.lastname: Gebhardt
authors.affiliation: Peter MacCallum Cancer Centre, 305 Grattan Street, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC 3010, Australia; Department of Pathology, University of Melbourne, Parkville, VIC 3010, Australia. Electronic address: kieran.harvey@petermac.org.
authors.forename: Kieran F
authors.initials: KF
authors.lastname: Harvey
mesh_terms: D006801:Humans; D009369:Neoplasms; D009929:Organ Size; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D015398:Signal Transduction
chemical_list: D017346:Protein Serine-Threonine Kinases