title: Sarsasapogenin reverses depressive-like behaviors and nicotinic acetylcholine receptors induced by olfactory bulbectomy.
abstract: Cholinergic signalling in the hippocampus may contribute to the aetiology of mood regulation. Antidepressants can reverse the increase in acetylcholinesterase (AChE) activity induced by olfactory bulbectomy. The activation of nicotinic acetylcholine receptors (nAChRs) also alleviates the symptoms of depression. This study advances the development of sarsasapogenin, which interacts with cholinergic signalling and has a favourable antidepressant profile in olfactory bulbectomised (OB) rats. We examined OB-induced changes in cholinergic signalling, as well as AChE, α4-nAChR, and α7-nAChR expression in the hippocampus. The results indicate that abnormal cholinergic signalling in the hippocampus contributes to the development of depression in the OB rat model. This depression may be alleviated following treatment with sarsasapogenin.
authors.affiliation: The Third People's Hospital of Liaocheng, Department of Neurology, Shandong, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Feng
authors.affiliation: The Third People's Hospital of Liaocheng, Department of Neurology, Shandong, China.
authors.forename: Xiao-Yang
authors.initials: XY
authors.lastname: Zhao
authors.affiliation: The Third People's Hospital of Liaocheng, Department of Neurology, Shandong, China.
authors.forename: Yi-Zhou
authors.initials: YZ
authors.lastname: Song
authors.affiliation: The Third People's Hospital of Liaocheng, Department of Neurology, Shandong, China.
authors.forename: Wen-Na
authors.initials: WN
authors.lastname: Liang
authors.affiliation: The Third People's Hospital of Liaocheng, Department of Neurology, Shandong, China. Electronic address: jiliangliu2016@163.com.
authors.forename: Ji-Liang
authors.initials: JL
authors.lastname: Liu
mesh_terms: D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D000928:Antidepressive Agents / Q000627:therapeutic use; D001522:Behavior, Animal / Q000187:drug effects*; D003863:Depression / Q000188:drug therapy / Q000378:metabolism; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D018722:Nicotinic Agonists / Q000494:pharmacology; D066194:Olfactory Cortex / Q000601:surgery; D017207:Rats, Sprague-Dawley; D011978:Receptors, Nicotinic / Q000378:metabolism*; D012903:Smell / Q000187:drug effects; D013150:Spirostans / Q000494:pharmacology*
chemical_list: D000928:Antidepressive Agents; D018722:Nicotinic Agonists; D011978:Receptors, Nicotinic; D013150:Spirostans; C046297:sarsasapogenin; D000109:Acetylcholine
keywords: Acetylcholinesterase; Depression; Olfactory bulbectomy; Sarsasapogenin; α4-nAChR; α7-nAChR