title: Thumb Imprint Based Detection of Hyperbilirubinemia Using Luminescent Gold Nanoclusters.
abstract: Early and easy detection of diseases, using point-of-care and inexpensive devices, not only provides option for early treatment but also reduces the risk of propagation. Herein we report the fabrication of a robust film based luminescence indicator of bilirubin, which can indicate hyperbilirubinemia through the thumb imprint of the patient. The UV-light induced luminescence intensity of the film, made out of chitosan stabilised gold (Au) nanoclusters, which was effectively quenched in the presence of Cu2+ions, recovered in the presence of bilirubin from skin or blood serum. Moreover, the sensitivity of detection of bilirubin was tuneable with the amount of Cu2+added, thereby facilitating the detection of the desired concentration range of bilirubin.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781039, India.
authors.forename: Srestha
authors.initials: S
authors.lastname: Basu
authors.affiliation: Centre for Nanotechnology, Indian Institute of Technology Guwahati, Guwahati 781039, India.
authors.forename: Amaresh Kumar
authors.initials: AK
authors.lastname: Sahoo
authors.affiliation: Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781039, India.
authors.forename: Anumita
authors.initials: A
authors.lastname: Paul
authors.affiliation: Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781039, India.|Centre for Nanotechnology, Indian Institute of Technology Guwahati, Guwahati 781039, India.
authors.forename: Arun
authors.initials: A
authors.lastname: Chattopadhyay
mesh_terms: D000818:Animals; D001663:Bilirubin / Q000032:analysis*; D003300:Copper / Q000737:chemistry*; D003878:Dermatoglyphics; D005260:Female; D006046:Gold / Q000737:chemistry*; D006801:Humans; D007565:Jaundice / Q000175:diagnosis*; D008297:Male; D053768:Metal Nanoparticles / Q000737:chemistry*; D019095:Point-of-Care Systems
chemical_list: D006046:Gold; D003300:Copper; D001663:Bilirubin