title: Evaluation of the occurrence of canine congenital sensorineural deafness in puppies of predisposed dog breeds using the brainstem auditory evoked response.
abstract: Canine congenital sensorineural deafness (CCSD) affects predisposed breeds of dogs and is primarily caused by an atrophy of the stria vascularis of the organ of Corti. The analysis of the brainstem auditory evoked response (BAER) is a reliable method for the evaluation of hearing in animals as it allows an accurate detection of unilateral or bilateral deafness. The occurrence of unilateral and bilateral deafness using the BAER was determined in a representative group of dogs in Poland, including Bull Terriers (n = 117), Australian Cattle Dogs (n = 62), English Setters (n = 32) and the Dogo Argentino (n = 32). Overall deafness, deafness in each dog breed and an association between deafness and phenotype were studied. Among the 243 dogs tested, 156 (81%) had a normal BAER, 27 (11%) were unilaterally deaf, and 12 (5%) were bilaterally deaf. The amplitudes and latencies of waves I, II, III, V, the V/I wave amplitude ratio, and wave I-V, I-III and III-V inter-peak intervals were recorded for each dog. Unilaterally and bilaterally deaf dogs were present in all the dog breeds studied. There were 17 (14.5%) deaf Bull Terriers, three (4.8%) deaf Australian Cattle Dogs, seven (21.9%) deaf English Setters, and 12 (37.5%) deaf Dogos Argentinos. Preventive BAER screening should be routinely performed in these four breeds to prevent the spread of genes responsible for deafness.
authors.affiliation: Department of Internal Diseases with a Clinic of Horses, Dogs and Cats, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences , pl. Grunwaldzki 47, 50-366 Wrocław , Poland.
authors.forename: Marta
authors.initials: M
authors.lastname: Płonek
authors.affiliation: Department of Internal Diseases with a Clinic of Horses, Dogs and Cats, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences , pl. Grunwaldzki 47, 50-366 Wrocław , Poland.
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Giza
authors.affiliation: Department of Internal Diseases with a Clinic of Horses, Dogs and Cats, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences , pl. Grunwaldzki 47, 50-366 Wrocław , Poland.
authors.forename: Artur
authors.initials: A
authors.lastname: Niedźwiedź
authors.affiliation: Department of Internal Diseases with a Clinic of Horses, Dogs and Cats, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences , pl. Grunwaldzki 47, 50-366 Wrocław , Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Kubiak
authors.affiliation: Department of Internal Diseases with a Clinic of Horses, Dogs and Cats, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences , pl. Grunwaldzki 47, 50-366 Wrocław , Poland.|Centre for Experimental Diagnostics and Biomedical Innovations , Wrocław , Poland.
authors.forename: Józef
authors.initials: J
authors.lastname: Nicpoń
authors.affiliation: Department of Internal Diseases with a Clinic of Horses, Dogs and Cats, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences , pl. Grunwaldzki 47, 50-366 Wrocław , Poland.
authors.forename: Marcin
authors.initials: M
authors.lastname: Wrzosek
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000151:congenital* / Q000235:genetics; D004285:Dogs; D016057:Evoked Potentials, Auditory, Brain Stem / Q000235:genetics / Q000502:physiology*; D020022:Genetic Predisposition to Disease; D006319:Hearing Loss, Sensorineural / Q000151:congenital / Q000235:genetics / Q000662:veterinary*
keywords: Canine congenital sensorineural deafness; brainstem auditory evoked response; dogs; predisposed breeds