title: Clinical Association of Chemokine (C-X-C motif) Ligand 1 (CXCL1) with Interstitial Pneumonia with Autoimmune Features (IPAF).
abstract: The term "interstitial pneumonia with autoimmune features" (IPAF) has been recently proposed. We here investigate the clinical characteristics of IPAF and evaluate the clinical implications of CXCL1-CXCR2 axis in IPAF. An increased plasma level of CXCL1 was exhibited in IPAF compared to idiopathic interstitial pneumonia (IIP), chronic obstructive pulmonary disease (COPD), and healthy controls. Additionally, plasma CXCL1 levels were clinically associated with diffusing capacity of the lungs for carbon monoxide (DLCO), erythrocyte sedimentation rate (ESR), and involved parenchyma extension in IPAF. Furthermore, circulating CXCL1 levels were highest in IPAF patients with acute exacerbations. CXCR2, the chemokine receptor for CXCL1, was readily observed in inflammatory aggregates and endothelial cells in IPAF lungs, but was lower in IIP lungs and healthy lungs. Interestingly, increased CXCL1 concentrations in BALF paralleled neutrophil counts in IPAF. Overall, the plasma concentrations of CXCL1 indicated the disease activity and prognosis in IPAF. Thus, the CXCL1/CXCR2 axis appears to be involved in the progression of IPAF.
authors.affiliation: Division of Rheumatology, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.|Institute of Rheumatology, Immunology and Allergy, Fudan University, Shanghai 200040, P.R. China.
authors.forename: Minrui
authors.initials: M
authors.lastname: Liang
authors.affiliation: Division of Rheumatology, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.|Institute of Rheumatology, Immunology and Allergy, Fudan University, Shanghai 200040, P.R. China.
authors.forename: Zhixing
authors.initials: Z
authors.lastname: Jiang
authors.affiliation: Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Huang
authors.affiliation: Division of Rheumatology, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.|Institute of Rheumatology, Immunology and Allergy, Fudan University, Shanghai 200040, P.R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
authors.affiliation: Division of Rheumatology, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.|Institute of Rheumatology, Immunology and Allergy, Fudan University, Shanghai 200040, P.R. China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Xue
authors.affiliation: Division of Rheumatology, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.|Institute of Rheumatology, Immunology and Allergy, Fudan University, Shanghai 200040, P.R. China.
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Zhu
authors.affiliation: Division of Rheumatology, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.|Institute of Rheumatology, Immunology and Allergy, Fudan University, Shanghai 200040, P.R. China.
authors.forename: Yiyun
authors.initials: Y
authors.lastname: Yu
authors.affiliation: Division of Rheumatology, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.|Institute of Rheumatology, Immunology and Allergy, Fudan University, Shanghai 200040, P.R. China.
authors.forename: Weiguo
authors.initials: W
authors.lastname: Wan
authors.affiliation: Department of Pulmonology, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.
authors.forename: Haihua
authors.initials: H
authors.lastname: Yang
authors.affiliation: Division of Rheumatology, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.|Institute of Rheumatology, Immunology and Allergy, Fudan University, Shanghai 200040, P.R. China.
authors.forename: Hejian
authors.initials: H
authors.lastname: Zou
mesh_terms: D000368:Aged; D001327:Autoimmune Diseases / Q000097:blood*; D001799:Blood Sedimentation; D002248:Carbon Monoxide / Q000097:blood; D054360:Chemokine CXCL1 / Q000097:blood*; D005260:Female; D006801:Humans; D054988:Idiopathic Interstitial Pneumonias / Q000097:blood*; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood; D023063:Receptors, Interleukin-8B / Q000097:blood
chemical_list: C475829:CXCL1 protein, human; D054360:Chemokine CXCL1; D023063:Receptors, Interleukin-8B; D002248:Carbon Monoxide