title: Carbon-Dot-Coated Alginate Beads as a Smart Stimuli-Responsive Drug Delivery System.
abstract: In this work, we report a smart stimuli-responsive drug delivery system (DDS) that can release drug depending upon the amount of pathogen (MRSA) present in the target. A greater amount of MRSA in the system will lead to more release of drug and vice versa. Carbon-dot-coated novel alginate beads (CA-CD) exhibiting superior stability was successfully used as smart drug delivery vehicle. Garlic extract (GE), which contains allicin, was taken as model drug system to demonstrate the phenomena. It was observed that GE loading was 19 and 78% with CA and CA-CD, respectively. CA-CD-GE shows pH-dependent controlled drug release, which results in increased therapeutic efficiency. CA-CD-GE is not only stimuli responsive but also a controlled drug release system as it releases drug according to the pathogen concentration (MRSA). All the three factors viz. drug release, MRSA concentration and pH of the medium are interdependent as when the cell divides, it produces secondary metabolites that lead to the decrease in pH of the medium. The drop in the pH value triggers drug release from the beads. And the effect of the drug is reflected by the MRSA cell death. Hence, we demonstrate a smart stimuli responsive DDS. However, such DDS will be useful in cases where increased amount of pathogen in the system will lead to reduction in pH.
authors.affiliation: Material Nanochemistry Laboratory, Physical Sciences Division and ‡Life Sciences Division, Institute of Advanced Study in Science and Technology , Paschim Boragaon, Garchuk, Guwahati 781035, India.
authors.forename: Sristi
authors.initials: S
authors.lastname: Majumdar
authors.affiliation: Material Nanochemistry Laboratory, Physical Sciences Division and ‡Life Sciences Division, Institute of Advanced Study in Science and Technology , Paschim Boragaon, Garchuk, Guwahati 781035, India.
authors.forename: Gargee
authors.initials: G
authors.lastname: Krishnatreya
authors.affiliation: Material Nanochemistry Laboratory, Physical Sciences Division and ‡Life Sciences Division, Institute of Advanced Study in Science and Technology , Paschim Boragaon, Garchuk, Guwahati 781035, India.
authors.forename: Neelam
authors.initials: N
authors.lastname: Gogoi
authors.affiliation: Material Nanochemistry Laboratory, Physical Sciences Division and ‡Life Sciences Division, Institute of Advanced Study in Science and Technology , Paschim Boragaon, Garchuk, Guwahati 781035, India.
authors.forename: Debajit
authors.initials: D
authors.lastname: Thakur
authors.affiliation: Material Nanochemistry Laboratory, Physical Sciences Division and ‡Life Sciences Division, Institute of Advanced Study in Science and Technology , Paschim Boragaon, Garchuk, Guwahati 781035, India.
authors.forename: Devasish
authors.initials: D
authors.lastname: Chowdhury
mesh_terms: D000464:Alginates / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D004220:Disulfides; D016503:Drug Delivery Systems / Q000379:methods*; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008863:Microspheres; D049329:Nanostructures / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013441:Sulfinic Acids / Q000737:chemistry
chemical_list: D000464:Alginates; D004220:Disulfides; D006603:Hexuronic Acids; D013441:Sulfinic Acids; C006452:allicin; D002244:Carbon; D020723:Glucuronic Acid
keywords: MRSA; alginate; carbon dot; drug delivery system; stimuli responsive