title: The Simultaneous Elevation of Oxidative Stress Markers and Wilms' Tumor 1 Gene during the Progression of Myelodysplastic Syndrome.
abstract: Oxidative stress is closely related to iron overload in myelodysplastic syndrome (MDS) and induces DNA damage. We evaluated the oxidative stress markers derivatives of reactive oxidative metabolites (dROM) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) during azacitidine treatment in an MDS patient. Simultaneous with an increase in the expression of Wilms' Tumor 1 (WT1) gene in the peripheral blood, the serum dROM level was elevated, and this increase was observed earlier than the increases in ferritin and 8-OHdG. Throughout the clinical course, dROM and 8-OHdG correlated significantly with WT1 and with ferritin, suggesting that changes in the oxidative stress marker levels reflect not only iron overload but also disease progression of MDS.
authors.affiliation: Department of Blood Transfusion, Toho University Medical Center Sakura Hospital, Japan.
authors.forename: Naomi
authors.initials: N
authors.lastname: Shimizu
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Hasunuma
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Matsuzawa
authors.forename: Youichi
authors.initials: Y
authors.lastname: Iwashita
authors.forename: Ichiro
authors.initials: I
authors.lastname: Tatsuno
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Yokota
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects; D001374:Azacitidine / Q000009:adverse effects; D014408:Biomarkers, Tumor / Q000097:blood; D002637:Chest Pain / Q000209:etiology; D004249:DNA Damage; D003676:Deferoxamine / Q000627:therapeutic use; D018450:Disease Progression; D017809:Fatal Outcome; D005293:Ferritins / Q000097:blood; D016162:Genes, Wilms Tumor; D006801:Humans; D019190:Iron Overload / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D009102:Multiple Organ Failure; D009190:Myelodysplastic Syndromes / Q000097:blood / Q000188:drug therapy / Q000235:genetics* / Q000503:physiopathology; D018384:Oxidative Stress; D017262:Siderophores / Q000627:therapeutic use
chemical_list: D000964:Antimetabolites, Antineoplastic; D014408:Biomarkers, Tumor; D017262:Siderophores; D005293:Ferritins; D003676:Deferoxamine; D001374:Azacitidine