title: High expression of Snail and NF-κB predicts poor survival in Chinese hepatocellular carcinoma patients.
abstract: In this study, we explored the roles of Snail and NF-κB in hepatocellular carcinoma (HCC). Samples of HCC tumor tissue were collected from 83 Chinese HCC patients. Snail and NF-κB expression was then examined based on immunohistochemical staining, and the relations between Snail and NF-κB expression and the clinical characteristics of the patients were assessed using Cox model analysis. Snail and NF-κB were both expressed in HCC tissue, and their levels were strongly correlated. In addition, levels of both Snail and NF-κB expression were negatively related to tumor differentiation, which was an independent factor predictive of survival in HCC patients. Snail and NF-κB may thus be useful markers of tumor differentiation and survival in HCC, and may also be useful for guiding treatment and exploring molecular mechanisms.
authors.affiliation: Department of Pathology, Department of Scientific Research Gansu Provincial Hospital, Lanzhou 730000, P.R. China.|Department of Scientific Research, Gansu Provincial Hospital, Lanzhou 730000, P.R. China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.affiliation: The Third Hospital of Gansu Province, Lanzhou 730020, P.R. China.
authors.forename: Xin
authors.initials: X
authors.lastname: Dong
authors.affiliation: Department of Pathology, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou 730050, P.R. China.
authors.forename: Dengcai
authors.initials: D
authors.lastname: Zhang
authors.affiliation: Department of Scientific Research, Gansu Provincial Hospital, Lanzhou 730000, P.R. China.
authors.forename: Xiaojie
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Scientific Research, Gansu Provincial Hospital, Lanzhou 730000, P.R. China.
authors.forename: Xinyu
authors.initials: X
authors.lastname: Zhu
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D006528:Carcinoma, Hepatocellular / Q000378:metabolism*; D045744:Cell Line, Tumor; D002681:China; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D016328:NF-kappa B / Q000378:metabolism*; D011379:Prognosis; D016016:Proportional Hazards Models; D000071250:Snail Family Transcription Factors / Q000378:metabolism*; D016019:Survival Analysis; D015854:Up-Regulation
chemical_list: D014408:Biomarkers, Tumor; D016328:NF-kappa B; D000071250:Snail Family Transcription Factors
keywords: Chinese population; NF-κB; Snail; hepatocellular carcinoma; survival