title: Coronary Spastic Angina Induced after Oral Desmopressin (DDAVP) Administration.
abstract: A 60-year-old man was prescribed oral desmopressin (1-deamino-8-D-arginine vasopressin acetate trihydrate; DDAVP) for nocturnal polyuria. One week after starting to take desmopressin, he frequently felt chest pain while resting. Coronary angiography revealed no organic stenosis; however, an acetylcholine provocation test showed severe coronary spasm with ST elevation. He was diagnosed with coronary spastic angina, and we stopped the oral desmopressin and added diltiazem. While DDAVP should dilate the coronary vessels in healthy subjects, it may provoke coronary vasospasm in patients with endothelial dysfunction. We should be careful to avoid triggering coronary spasm when administering DDAVP to patients that may have potential endothelial dysfunction.
authors.affiliation: Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Adachi
authors.forename: Kenichi
authors.initials: K
authors.lastname: Sakakura
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Akashi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Wada
authors.forename: Shin-Ichi
authors.initials: SI
authors.lastname: Momomura
authors.forename: Hideo
authors.initials: H
authors.lastname: Fujita
mesh_terms: D000109:Acetylcholine / Q000008:administration & dosage; D000284:Administration, Oral; D000787:Angina Pectoris / Q000139:chemically induced* / Q000150:complications / Q000175:diagnosis; D050034:Antidiuretic Agents / Q000009:adverse effects / Q000627:therapeutic use; D017023:Coronary Angiography; D003329:Coronary Vasospasm / Q000139:chemically induced / Q000150:complications / Q000175:diagnosis; D003331:Coronary Vessels / Q000187:drug effects / Q000503:physiopathology; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D004110:Diltiazem / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009128:Muscle Spasticity; D053158:Nocturia / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D050034:Antidiuretic Agents; D004110:Diltiazem; D003894:Deamino Arginine Vasopressin; D000109:Acetylcholine