title: Impact of sleep disordered breathing on carotid body size.
abstract: We tested the hypotheses that: (1) carotid body size can be measured by computed tomographic angiography (CTA) with high inter-observer agreement, and (2) patients with sleep apnea exhibit larger carotid bodies than those without sleep apnea. A chart review was conducted from patients who underwent neck CTA and polysomnography at the Mayo Clinic between January 2000 and February 2015. Widest axial measurements of the carotid bodies, performed independently by two radiologists, were possible in 81% of patients. Intra-class correlation coefficients ranged from 0.93 to 0.95 (Right carotid body: 0.93; Left: 0.94; Average: 0.95). Widest axial measurements of the carotid bodies were greater in patients with sleep apnea (n=32) compared to controls (n=46, P-value range 0.02-0.04). After adjusting for age, no differences in carotid body size were observed between the patient groups (P-value range 0.45-0.59). We conclude carotid body size can be detected by CTA with high inter-observer agreement; however, carotid body size is not increased in patients with sleep apnea.
authors.affiliation: Department of Radiology, Mayo Clinic, Rochester, MN, USA. Electronic address: Welch.Brian@mayo.edu.
authors.forename: Brian T
authors.initials: BT
authors.lastname: Welch
authors.affiliation: Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA. Electronic address: Petersen-Jones.Humphrey@mayo.edu.
authors.forename: Humphrey G
authors.initials: HG
authors.lastname: Petersen-Jones
authors.affiliation: Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA. Electronic address: Eugene.Andy@mayo.edu.
authors.forename: Andy R
authors.initials: AR
authors.lastname: Eugene
authors.affiliation: Department of Radiology, Mayo Clinic, Rochester, MN, USA. Electronic address: Brinjikji.Waleed@mayo.edu.
authors.forename: Waleed
authors.initials: W
authors.lastname: Brinjikji
authors.affiliation: Department of Radiology, Mayo Clinic, Rochester, MN, USA. Electronic address: Kallmes.David@mayo.edu.
authors.forename: David F
authors.initials: DF
authors.lastname: Kallmes
authors.affiliation: Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA. Electronic address: Curry.Timothy@mayo.edu.
authors.forename: Timothy B
authors.initials: TB
authors.lastname: Curry
authors.affiliation: Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA. Electronic address: Joyner.Michael@mayo.edu.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Joyner
authors.affiliation: Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA. Electronic address: Limberg.Jacqueline@mayo.edu.
authors.forename: Jacqueline K
authors.initials: JK
authors.lastname: Limberg
mesh_terms: D000368:Aged; D001794:Blood Pressure / Q000502:physiology; D002344:Carotid Body / Q000000981:diagnostic imaging* / Q000473:pathology*; D000072226:Computed Tomography Angiography; D005260:Female; D007839:Functional Laterality; D006257:Head / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D009333:Neck / Q000000981:diagnostic imaging; D017286:Polysomnography; D012189:Retrospective Studies; D012891:Sleep Apnea Syndromes / Q000000981:diagnostic imaging / Q000473:pathology*; D018709:Statistics, Nonparametric
keywords: Angiography; Apnea hypopnea index; Computed tomography; Hypoxemia; Sleep apnea