title: The multifaceted roles of NUCLEAR FACTOR-Y in Arabidopsis thaliana development and stress responses.
abstract: NUCLEAR FACTOR-Y (NF-Y) is a heterotrimeric transcription factor (TF) consisting of evolutionarily distinct NF-YA, NF-YB and NF-YC subunits. The functional NF-Y heterotrimer binds to CCAAT elements in eukaryotic gene promoters and influences their expression. The genome of the model organism Arabidopsis thaliana encodes 10 distinct NF-YA, NF-YB, and NF-YC proteins, allowing for enormous combinatorial and functional diversity. Two decades of research have elucidated the importance of NF-Ys in plant growth, development and stress responses; however, the molecular mechanisms of action remain largely unexplored. Intriguingly, recent evidence suggests that NF-Ys are frequently associated with other groups of TFs, expanding the potential NF-Y combinatorial complexity. Further, information regarding the regulation of individual NF-Y subunits at the transcriptional and post-transcriptional level is beginning to emerge. In this review, we will identify developing trends within the NF-Y field and discuss recent progress towards a better understanding of NF-Y function, molecular action, and regulation in the context of Arabidopsis. This article is part of a Special Issue entitled: Nuclear Factor Y in Development and Disease, edited by Prof. Roberto Mantovani.
authors.affiliation: Department of Microbiology and Plant Biology, University of Oklahoma, Norman, OK 73019, United States.
authors.forename: Swadhin
authors.initials: S
authors.lastname: Swain
authors.affiliation: Department of Microbiology and Plant Biology, University of Oklahoma, Norman, OK 73019, United States.
authors.forename: Zachary A
authors.initials: ZA
authors.lastname: Myers
authors.affiliation: Department of Microbiology and Plant Biology, University of Oklahoma, Norman, OK 73019, United States.
authors.forename: Chamindika L
authors.initials: CL
authors.lastname: Siriwardana
authors.affiliation: Department of Microbiology and Plant Biology, University of Oklahoma, Norman, OK 73019, United States. Electronic address: benholt@ou.edu.
authors.forename: Ben F
authors.initials: BF
authors.lastname: Holt
mesh_terms: D017360:Arabidopsis / Q000235:genetics / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism*; D023081:CCAAT-Binding Factor / Q000235:genetics / Q000378:metabolism*; D018506:Gene Expression Regulation, Plant / Q000502:physiology*; D013312:Stress, Physiological / Q000502:physiology*; D014158:Transcription, Genetic / Q000502:physiology*
chemical_list: D029681:Arabidopsis Proteins; D023081:CCAAT-Binding Factor
keywords: Abiotic stress responses; NUCLEAR FACTOR Y (NF-Y); Plant development; Primary metabolism; Transcription factor