title: Pd-Catalyzed Spirocyclization via C-H Activation and Benzyne Insertion.
abstract: A palladium-catalyzed spirocyclization forming spirooxindoles and spirodihydrobenzofurans has been achieved. Mechanistic studies suggest that the transformation proceeds through sequential carbopalladation, C-H activation, and benzyne insertion. Both classes of spirocycles have been synthesized in good to excellent yields, and the procedure is readily scalable.
authors.affiliation: Davenport Research Laboratories, Department of Chemistry, University of Toronto , Toronto, Ontario M5S 3H6, Canada.
authors.forename: Hyung
authors.identifier: 0000-0003-4573-2160
authors.initials: H
authors.lastname: Yoon
authors.affiliation: Davenport Research Laboratories, Department of Chemistry, University of Toronto , Toronto, Ontario M5S 3H6, Canada.
authors.forename: Alexis
authors.initials: A
authors.lastname: Lossouarn
authors.affiliation: Davenport Research Laboratories, Department of Chemistry, University of Toronto , Toronto, Ontario M5S 3H6, Canada.
authors.forename: Felicitas
authors.initials: F
authors.lastname: Landau
authors.affiliation: Davenport Research Laboratories, Department of Chemistry, University of Toronto , Toronto, Ontario M5S 3H6, Canada.
authors.forename: Mark
authors.initials: M
authors.lastname: Lautens