title: Patient-Reported Outcomes Following Platelet-Rich Plasma Injections in Treating Osteochondral Lesions of the Talus: A Critically Appraised Topic.
abstract: Clinical Scenario: Osteochondral lesions (OCLs) of the talus can result from ankle sprains which are the most common injury in the physically active. Recently, platelet-rich plasma (PRP) has been used to develop an innovate treatment for OCLs of the talus.
  
  
  OBJECTIVE
  Do PRP injections improve self-reported pain and ankle function in patients with OCL of the talus? Summary of Key Findings: 3 randomized controlled trials were included. One of the studies compared a single dose of PRP to a single dose of hyaluronic acid (HA) or saline when added as an adjunct to microfracture surgery. Another study compared a group receiving a single dose of PRP after microfracture surgery to a group that only received microfracture surgery. The last study compared a series of 3 PRP injections to a series of 3 HA injections. In all 3 studies PRP appeared to be more effective in pain and function outcomes than comparison treatments. The superior outcomes of PRP were demonstrated at times as short as 4 weeks and as long as 25 months. Clinical Bottom Line: There is moderate to strong evidence that PRP produces favorable, short-term, pain and function results compared to HA, saline, and/or microfracture surgery alone. Strength of Recommendation: Level 2.
authors.forename: Samuel F
authors.initials: SF
authors.lastname: Jazzo
authors.forename: Daniel
authors.initials: D
authors.lastname: Scribner
authors.forename: Stephanie
authors.initials: S
authors.lastname: Shay
authors.forename: Kyung-Min
authors.initials: KM
authors.lastname: Kim
mesh_terms: D016512:Ankle Injuries / Q000503:physiopathology; D002358:Cartilage, Articular / Q000293:injuries / Q000601:surgery; D006801:Humans; D006820:Hyaluronic Acid / Q000627:therapeutic use; D007267:Injections; D010007:Osteochondritis / Q000628:therapy*; D059408:Pain Management; D000071066:Patient Reported Outcome Measures; D053657:Platelet-Rich Plasma; D016032:Randomized Controlled Trials as Topic; D057566:Self Report; D013628:Talus / Q000473:pathology* / Q000601:surgery
chemical_list: D006820:Hyaluronic Acid
keywords: ankle dysfunction; ankle injury; ankle pain