title: Treatment of Alcohol Use Disorder in Patients with Alcoholic Liver Disease.
abstract: Alcohol is a leading cause of liver disease worldwide. Although alcohol abstinence is the crucial therapeutic goal for patients with alcoholic liver disease, these patients have less access to psychosocial, behavioral, and/or pharmacologic treatments for alcohol use disorder. Psychosocial and behavioral therapies include 12-step facilitation, brief interventions, cognitive behavioral therapy, and motivational enhancement therapy. In addition to medications approved by the US Food and Drug Administration for alcohol use disorder (disulfiram, naltrexone, and acamprosate), recent efforts to identify potential new treatments have yielded promising candidate pharmacotherapies. Finally, more efforts are needed to integrate treatments across disciplines toward patient-centered approaches in the management of patients with alcohol use disorder and alcoholic liver disease.
authors.affiliation: Section on Clinical Psychoneuroendocrinology and Neuropsychopharmacology, National Institute on Alcohol Abuse and Alcoholism and National Institute on Drug Abuse, National Institutes of Health, Bethesda, Md; Center for Alcohol and Addiction Studies, Department of Behavioral and Social Sciences, Brown University, Providence, RI. Electronic address: lorenzo.leggio@nih.gov.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Leggio
authors.affiliation: Section on Clinical Psychoneuroendocrinology and Neuropsychopharmacology, National Institute on Alcohol Abuse and Alcoholism and National Institute on Drug Abuse, National Institutes of Health, Bethesda, Md. Electronic address: leemary@mail.nih.gov.
authors.forename: Mary R
authors.initials: MR
authors.lastname: Lee
mesh_terms: D000437:Alcoholism / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D001521:Behavior Therapy; D018450:Disease Progression; D006801:Humans; D008108:Liver Diseases, Alcoholic / Q000473:pathology / Q000628:therapy*
keywords: Alcohol use disorder; Alcoholic liver disease; Liver disease; Treatment