title: Utilization of chitosan-caged liposomes to push the boundaries of therapeutic delivery.
abstract: Liposomes are self-assembled bilayer vesicles which have attracted a great deal of interest as potential carriers for a wide range of therapeutic agents. They have significantly decreased toxicity of drugs while improving or at least maintaining their efficacy. However, their further development has been hampered by their considerable instabilities and, in some cases, providing comparable efficacy to conventional products. Decoration of liposomal nanocarriers with chitosan (CS) and its derivatives has recently gained importance to overcome this obstacle. CS, a cationic polysaccharide, has prompted the continuous impetus for the advent of efficient drug delivery systems owing to its unique characteristics. CS decoration of liposomes confers high mucoadhesion capacity, enhanced carrier permeability, and sterically stabilized properties. The number of examples having been explained within the present review through different administration routes and for various applications clearly heralds the promise of CS caged liposomes for the pharmaceutical market.
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Sonia
authors.initials: S
authors.lastname: Alavi
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Azadeh
authors.initials: A
authors.lastname: Haeri
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Pharmaceutical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: Sdadashzadeh@sbmu.ac.ir.
authors.forename: Simin
authors.initials: S
authors.lastname: Dadashzadeh
mesh_terms: D048271:Chitosan / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D008081:Liposomes; D010539:Permeability
chemical_list: D004337:Drug Carriers; D008081:Liposomes; D048271:Chitosan
keywords: Administration routes; Chitosan; Chitosan derivatives; Liposomes; Mucoadhesion