title: Sorption and desorption of 17α-trenbolone and trendione on five soils.
abstract: The metabolites 17α-trenbolone and 17α-estradiol are principal metabolites in cattle excreta following the administration of Synovex®ONE, which contains trenbolone acetate and estradiol benzoate. As part of the environmental assessment of the use of Synovex ONE, data were generated to characterize the fate of 17α-trenbolone, and its metabolite trendione in the environment. Predictions of the fate and environmental concentrations of these hormones after land application require accurate estimates of the sorption of these compounds in soils. The sorption and desorption of 17α-trenbolone and trendione were measured at 5 nominal concentrations in 5 soils from different geologic settings using a batch equilibrium technique following guideline 106 of the Organisation for Economic Co-operation and Development. Both the sorption and desorption of 17α-trenbolone and trendione to soils were adequately described by the Freundlich sorption model and by linear partition coefficients. The mean sorption coefficients were 9.04 mL/g and 32.2 mL/g for 17α-trenbolone and trendione, respectively. The corresponding mean Freundlich sorption exponents were 0.88 and 0.98, respectively. Sorption of 17α-trenbolone and trendione was correlated principally with soil organic carbon. Average sorption coefficients normalized to soil organic carbon content (KOC) were 460 mL/g and 1804 mL/g for 17α-trenbolone and trendione, respectively. The mean desorption coefficients were 22.1 mL/g and 43.8 mL/g for 17α-trenbolone and trendione, respectively. Calculated hysteresis coefficients based on the difference in the area between sorption and desorption isotherms indicated that sorption equilibrium was not fully reversible and hysteresis of desorption isotherms occurred for both 17α-trenbolone and trendione. Environ Toxicol Chem 2017;36:613-620. © 2016 SETAC.
authors.affiliation: Zoetis, Kalamazoo, Michigan, USA.
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Robinson
authors.affiliation: Exponent, Washington, DC, USA.
authors.forename: Qingli
authors.initials: Q
authors.lastname: Ma
authors.affiliation: Exponent, Cary, North Carolina, USA.
authors.forename: Jane P
authors.initials: JP
authors.lastname: Staveley
authors.affiliation: Phase II+, Kalamazoo, Michigan, USA.
authors.forename: Walter J
authors.initials: WJ
authors.lastname: Smolenski
mesh_terms: D000327:Adsorption; D000818:Animals; D002417:Cattle; D004784:Environmental Monitoring / Q000379:methods*; D004958:Estradiol / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism; D004963:Estrenes / Q000737:chemistry* / Q000378:metabolism; D005243:Feces / Q000737:chemistry; D017408:Guidelines as Topic; D007700:Kinetics; D008962:Models, Theoretical; D015394:Molecular Structure; D009009:Montana; D009658:North Dakota; D066150:Organisation for Economic Co-Operation and Development; D012987:Soil / Q000737:chemistry*; D012989:Soil Pollutants / Q000737:chemistry* / Q000378:metabolism; D014204:Trenbolone Acetate / Q000737:chemistry* / Q000378:metabolism
chemical_list: D004963:Estrenes; D012987:Soil; D012989:Soil Pollutants; C074283:estradiol 3-benzoate; C070427:trendione; D004958:Estradiol; D014204:Trenbolone Acetate
keywords: Androgens; Sorption; Synovex® ONE; Trenbolone; Veterinary medicines