title: Association between the HOTAIR polymorphisms and cancer risk: an updated meta-analysis.
abstract: OBJECTIVE
  LncRNA HOTAIR plays an important role in many cancer. Several studies have shown that some HOTAIR SNPs might be associated with tumor risk in case-control studies, but the results are inconsistent and inconclusive. Therefore, it is necessary to better evaluate association between the HOTAIR SNPs and the risk of cancer.
  
  
  RESULTS
  rs920778, rs7958904 and rs874945 but not rs4759314 and rs1899663 loci were significantly related to cancer risk, among of which rs920778 and rs874945 increased and rs7958904 decreased cancer risk, respectively. Moreover, rs920778 is significantly susceptible in both Asian population and digestive cancer risks.
  
  
  METHODS
  Data were collected from PubMed, Embase and Web of Science. A total of 11 case-control studies were selected for the quantitative analysis. Software Stata (Version 12) was used to calculate Odds ratios (ORs) and 95% confidence intervals (CIs) to evaluate the strength of the associations. Subgroup analysis, sensitivity analysis, and publication bias were also performed. Five HOTAIR SNPs were finally enrolled in the study.
  
  
  CONCLUSIONS
  HOTAIR SNP rs920778, rs7958904 and rs874945 are susceptible to cancer risk. SNP rs920778 is also a useful risk factor in evaluation of Asian population and digestive cancer. In addition, the cancer risk SNP rs874945 is first reported in the meta-analysis.
authors.affiliation: Department of Medical Genetics, China Medical University, Shenyang, 110122, P.R. China.
authors.forename: Zhao-Xiong
authors.initials: ZX
authors.lastname: Zhang
authors.affiliation: Department of Medical Genetics, China Medical University, Shenyang, 110122, P.R. China.
authors.forename: Xue
authors.initials: X
authors.lastname: Tong
authors.affiliation: Department of Medical Genetics, China Medical University, Shenyang, 110122, P.R. China.
authors.forename: Wan-Ni
authors.initials: WN
authors.lastname: Zhang
authors.affiliation: Department of Medical Genetics, China Medical University, Shenyang, 110122, P.R. China.
authors.forename: Wei-Neng
authors.initials: WN
authors.lastname: Fu
mesh_terms: D044466:Asian People / Q000235:genetics; D004067:Digestive System Neoplasms / Q000235:genetics; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D062085:RNA, Long Noncoding / Q000235:genetics*
chemical_list: C561566:HOTAIR long untranslated RNA, human; D062085:RNA, Long Noncoding
keywords: HOTAIR; SNP; cancer; meta-analysis; susceptible risk