title: The efficacy of fibrin glue injection in the prostatic fossa on decreasing postoperative bleeding following transurethral resection of prostate.
abstract: BACKGROUND
  To evaluate the efficacy of fibrin glue injection in the prostatic fossa at the end of transurethral resection of prostate (TURP), in decreasing postoperative bleeding in patient with benign prostatic hyperplasia (BPH).
  
  
  METHODS
  In this prospective randomized clinical trial, sixty patients with BPH, who were a candidate for TURP, were randomly divided into two equal groups. In the intervention group, 10cc of fibrin glue was injected in the prostatic fossa at the end of the surgery; through a 5 Fr feeding tube attached to Foley catheter and its tip was proximal to the balloon of catheter. The other thirty patients created the control group. Hemoglobin (Hb) level and lower urinary tract symptoms (LUTS) score were recorded before and 6, 24, 48 h, and 5 days after TURP.
  
  
  RESULTS
  The mean age of the patients and prostate volumes were comparable between the groups. The mean Hb level before and 6 h after TURP were not different between the two groups, however, 24 and 48 h and 5 days after TURP, there was a significant difference as well as a higher decrease in the mean Hb level of the control group (P= 0.023). The mean LUTS score was not statistically different between the two groups.
  
  
  CONCLUSIONS
  Fibrin glue injection in the prostatic after TURP reduces postoperative bleeding without any effect on LUTS score in patients with BPH.
authors.affiliation: Isfahan Kidney Transplantation Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Mohammad Hatef
authors.initials: MH
authors.lastname: Khorrami
authors.affiliation: Isfahan Kidney Transplantation Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Farhad
authors.initials: F
authors.lastname: Tadaion
authors.affiliation: Department of Urology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Iman
authors.initials: I
authors.lastname: Ghanaat
authors.affiliation: Isfahan Kidney Transplantation Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Farshid
authors.initials: F
authors.lastname: Alizadeh
keywords: Benign prostatic hyperplasia; fibrin glue; postoperative bleeding; prostate; transurethral resection