title: Improving access to tuberculosis preventive therapy and treatment for children.
abstract: Children suffer a huge burden of disease in tuberculosis (TB) endemic countries. This disease burden was largely invisible when TB control programmes focused exclusively on adults with sputum smear-positive disease. High-level advocacy and better data have improved visibility, but the establishment of functional paediatric TB programmes remains challenging. The key issues that limit children's access to TB preventive therapy and treatment in endemic areas are briefly discussed. Barriers to preventive therapy include (1) the perceived inability to rule out active disease, (2) fear of creating drug resistance, (3) non-implementation of existing guidelines in the absence of adequate monitoring, and (4) poor adherence with long preventive therapy courses. Barriers to TB treatment include (1) perceived diagnostic difficulties, (2) non-availability of chest radiography, (3) young children presenting to unprepared maternal and child health (MCH) services, and (4) the absence of child-friendly formulations. With drug-resistant disease there is currently no guidance on the use of preventive therapy and treatment is usually restricted to cases with bacteriologically confirmed disease, which excludes most young children from care, even if their likely source case has documented drug-resistant TB.
authors.affiliation: The Children's Hospital at Westmead and the Marie Bashir Institute for Infectious Diseases and Biosecurity (MBI), Sydney Medical School, University of Sydney, Locked Bag 4001, Sydney, New South Wales, 2145, Australia. Electronic address: ben.marais@health.nsw.gov.au.
authors.forename: Ben J
authors.initials: BJ
authors.lastname: Marais
mesh_terms: D019072:Antibiotic Prophylaxis / Q000379:methods*; D002648:Child; D002651:Child Advocacy; D006297:Health Services Accessibility / Q000458:organization & administration*; D006801:Humans; D015397:Program Evaluation; D058996:Quality Improvement; D011787:Quality of Health Care; D013183:Sputum / Q000382:microbiology; D014376:Tuberculosis / Q000188:drug therapy / Q000517:prevention & control*
keywords: Children; Drug-resistant; Tuberculosis