title: Cardiac Glycoside Constituents of Streblus asper with Potential Antineoplastic Activity.
abstract: Three new (1-3) and two known (4 and 5) cytotoxic cardiac glycosides were isolated and characterized from a medicinal plant, Streblus asper Lour. (Moraceae), collected in Vietnam, with six new analogues and one known derivative (5a-g) synthesized from (+)-strebloside (5). A preliminary structure-activity relationship study indicated that the C-10 formyl and C-5 and C-14 hydroxy groups and C-3 sugar unit play important roles in the mediation of the cytotoxicity of (+)-strebloside (5) against HT-29 human colon cancer cells. When evaluated in NCr nu/nu mice implanted intraperitoneally with hollow fibers facilitated with either MDA-MB-231 human breast or OVCAR3 human ovarian cancer cells, (+)-strebloside (5) showed significant cell growth inhibitory activity in both cases, in the dose range 5-30 mg/kg.
authors.forename: Yulin
authors.initials: Y
authors.lastname: Ren
authors.affiliation: Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago , Chicago, Illinois 60612, United States.
authors.forename: Wei-Lun
authors.initials: WL
authors.lastname: Chen
authors.affiliation: Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago , Chicago, Illinois 60612, United States.
authors.forename: Daniel D
authors.initials: DD
authors.lastname: Lantvit
authors.forename: Ellen J
authors.initials: EJ
authors.lastname: Sass
authors.forename: Pratik
authors.initials: P
authors.lastname: Shriwas
authors.affiliation: Institute of Ecology and Biological Resources, Vietnam Academy of Science and Technology , Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam.
authors.forename: Tran Ngoc
authors.initials: TN
authors.lastname: Ninh
authors.forename: Hee-Byung
authors.initials: HB
authors.lastname: Chai
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago , Chicago, Illinois 60612, United States.|Science and Education, Field Museum of Natural History , Chicago, Illinois 60605, United States.
authors.forename: Djaja D
authors.initials: DD
authors.lastname: Soejarto
authors.forename: Xiaozhuo
authors.initials: X
authors.lastname: Chen
authors.forename: David M
authors.initials: DM
authors.lastname: Lucas
authors.affiliation: Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago , Chicago, Illinois 60612, United States.|School of Pharmacy, University of Wisconsin-Madison , Madison, Wisconsin 53705, United States.
authors.forename: Steven M
authors.initials: SM
authors.lastname: Swanson
authors.affiliation: Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago , Chicago, Illinois 60612, United States.
authors.forename: Joanna E
authors.initials: JE
authors.lastname: Burdette
authors.forename: A Douglas
authors.identifier: 0000-0002-6647-8707
authors.initials: AD
authors.lastname: Kinghorn
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002301:Cardiac Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D019073:HT29 Cells; D006801:Humans; D051379:Mice; D015394:Molecular Structure; D029586:Moraceae / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal; D013329:Structure-Activity Relationship; D014744:Vietnam
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D002301:Cardiac Glycosides