title: APOE gene and neuropsychiatric disorders and endophenotypes: A comprehensive review.
abstract: The Apolipoprotein E (APOE) gene is one of the main candidates in neuropsychiatric genetics, with hundreds of studies carried out in order to explore the possible role of polymorphisms in the APOE gene in a large number of neurological diseases, psychiatric disorders, and related endophenotypes. In the current article, we provide a comprehensive review of the structural and functional aspects of the APOE gene and its relationship with brain disorders. Evidence from genome-wide association studies and meta-analyses shows that the APOE gene has been significantly associated with several neurodegenerative disorders. Cellular and animal models show growing evidence of the key role of APOE in mechanisms of brain plasticity and behavior. Future analyses of the APOE gene might find a possible role in other neurological diseases and psychiatric disorders and related endophenotypes. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Laboratory of Neuropsychiatric Genetics, Biomedical Sciences Research Group, School of Medicine, Universidad Antonio Nariño, Bogotá, Colombia.|PhD Program in Health Sciences, School of Medicine, Universidad Antonio Nariño, Bogotá, Colombia.
authors.forename: Diego A
authors.initials: DA
authors.lastname: Forero
authors.affiliation: Novartis Pharmaceuticals Corporation, East Hanover, New Jersey.
authors.forename: Sandra
authors.initials: S
authors.lastname: López-León
authors.affiliation: Departamento de Nutrición y Bioquímica, Pontificia Universidad Javeriana, Bogotá, Colombia.
authors.forename: Yeimy
authors.initials: Y
authors.lastname: González-Giraldo
authors.affiliation: Chemistry Department, Juniata College, Huntingdon, Pennsylvania.
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Dries
authors.affiliation: Laboratory of Neuropsychiatric Genetics, Biomedical Sciences Research Group, School of Medicine, Universidad Antonio Nariño, Bogotá, Colombia.
authors.forename: Angela J
authors.initials: AJ
authors.lastname: Pereira-Morales
authors.affiliation: Laboratory of Neuropsychiatric Genetics, Biomedical Sciences Research Group, School of Medicine, Universidad Antonio Nariño, Bogotá, Colombia.
authors.forename: Karen M
authors.initials: KM
authors.lastname: Jiménez
authors.affiliation: PhD Program in Health Sciences, School of Medicine, Universidad Antonio Nariño, Bogotá, Colombia.
authors.forename: Juan E
authors.initials: JE
authors.lastname: Franco-Restrepo
mesh_terms: D000818:Animals; D001057:Apolipoproteins E / Q000235:genetics* / Q000378:metabolism; D001921:Brain / Q000378:metabolism / Q000473:pathology; D058068:Endophenotypes; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D001523:Mental Disorders / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D019636:Neurodegenerative Diseases / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D011110:Polymorphism, Genetic
chemical_list: C000612345:ApoE protein, human; D001057:Apolipoproteins E
keywords: Apolipoprotein E; candidate gene; meta-analyses; neurogenetics; neuropsychiatric genetics