title: In vitro corrosion properties and cytocompatibility of Fe-Ga alloys as potential biodegradable metallic materials.
abstract: The in vitro biodegradable properties and cytocompatibility of Fe-Ga alloys including Fe81Ga19, (Fe81Ga19)98B2and (Fe81Ga19)99.5(TaC)0.5, and pure Fe were investigated for biomedical applications. The microstructure of the alloys was characterized using X-ray diffraction spectroscopy and optical microscopy. The results showed that A2 and D03phases were detected for the three types of Fe-Ga alloys, and additional Fe2B and TaC phases were found in the (Fe81Ga19)98B2and (Fe81Ga19)99.5(TaC)0.5alloys, respectively. The corrosion rates of the Fe-Ga alloys were higher than that of pure Fe, as demonstrated by both potentiodynamic polarization measurements and immersion tests in simulated body fluid. The alloying element Ga lowered the corrosion potential of the Fe matrix and made it more susceptible to corrosion. Severe pitting corrosion developed on the surface of the Fe81Ga19alloy after the addition of ternary B or TaC due to the multi-phase microstructures. The MC3T3-E1 cells exhibited good adhesion and proliferation behavior on the surfaces of the Fe-Ga alloys after culture for 4h and 24h.
authors.affiliation: School of Materials Science and Engineering, Beihang University, Beijing 100191, China.
authors.forename: Henan
authors.initials: H
authors.lastname: Wang
authors.affiliation: School of Materials Science and Engineering, Beihang University, Beijing 100191, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: School of Materials Science and Engineering, Beihang University, Beijing 100191, China.
authors.forename: Jinghua
authors.initials: J
authors.lastname: Liu
authors.affiliation: School of Materials Science and Engineering, Beihang University, Beijing 100191, China.
authors.forename: Chengbao
authors.initials: C
authors.lastname: Jiang
authors.affiliation: School of Materials Science and Engineering, Beihang University, Beijing 100191, China. Electronic address: liyan@buaa.edu.cn.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
mesh_terms: D020341:Absorbable Implants; D000497:Alloys / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D002460:Cell Line; D003343:Corrosion; D005708:Gallium / Q000737:chemistry / Q000494:pharmacology; D007501:Iron / Q000737:chemistry / Q000494:pharmacology; D008422:Materials Testing; D051379:Mice
chemical_list: D000497:Alloys; D005708:Gallium; D007501:Iron
keywords: Biodegradable metals; Corrosion; Cytocompatibility; Fe-Ga alloys