title: Evaluation of the caries-preventive effect of toothpaste containing surface prereacted glass-ionomer filler.
abstract: OBJECTIVE
  Although fluoride interventions have the most consistent benefit in preventing caries, caries still develop in high-risk individuals. Authors have evaluated the effectiveness of toothpastes containing surface prereacted glass-ionomer (S-PRG) filler in preventing tooth demineralization.
  
  
  METHODS
  Human tooth enamel blocks were randomly assigned to six groups (30 blocks/group): no treatment (a), and toothpaste containing either 1500 ppm fluoride as sodium monofluorophosphate (NaMFP) (b), 0 wt% S-PRG (b), 1 wt% S-PRG (d), 5 wt% S-PRG (e), or 20 wt% S-PRG (f). Early caries developed on each block by 7-days demineralization using a microbial caries model. Mineral loss (Δz) and lesion depth (LD) were determined using transverse microradiography.
  
  
  RESULTS
  Relative to the control, all toothpastes, except 0% S-PRG, significantly (analysis of variance, Tukey's, P<.0001) reduced Δz and LD at varying percentages. With regard to Δz, all comparisons were significant (P<.0001), except 0% S-PRG vs the control. Otherwise, S-PRG 1%, 5%, and 20% had 0.50, 0.37, and 0.27 times Δz compared to the control, respectively, while NaMFP had 0.61 times Δz compared to the control. LD followed an almost similar trend as Δz.
  
  
  CONCLUSIONS
  The findings of the present study demonstrate the effectiveness of toothpaste containing S-PRG filler in inhibiting tooth demineralization in the presence of bacterial plaque, thus highlighting its potential as an effective caries-control tool for individuals at high risk of developing caries.
authors.affiliation: Department of Comprehensive Dentistry, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
authors.forename: Bennett Tochukwu
authors.initials: BT
authors.lastname: Amaechi
authors.affiliation: Department of Developmental Dentistry, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
authors.forename: Meredith C
authors.initials: MC
authors.lastname: Key
authors.affiliation: Department of Comprehensive Dentistry, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
authors.forename: Sabarathnam
authors.initials: S
authors.lastname: Balu
authors.affiliation: Department of Restorative Dentistry, University of Nigeria, Enugu, Nigeria.
authors.forename: Linda Ogechukwu
authors.initials: LO
authors.lastname: Okoye
authors.affiliation: Department of Developmental Dentistry, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
authors.forename: Peter Thiuri
authors.initials: PT
authors.lastname: Gakunga
mesh_terms: D000180:Acrylic Resins / Q000494:pharmacology* / Q000627:therapeutic use*; D003731:Dental Caries / Q000517:prevention & control*; D003743:Dental Enamel / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D012822:Silicon Dioxide / Q000494:pharmacology* / Q000627:therapeutic use*; D013499:Surface Properties; D014100:Toothpastes / Q000627:therapeutic use*
chemical_list: D000180:Acrylic Resins; D014100:Toothpastes; C015897:glass ionomer; D012822:Silicon Dioxide
keywords: caries prevention; fluoride; ion-releasing; surface prereacted glass-ionomer filler; toothpaste