title: Epilepsy and ion channels.
abstract: Many mutations of genes for ion channels result in some epilepsies. Their electrophysiological studies reveal pathophysiological mechanisms underlining epilepsy and also mechanism of action of several antiepileptic drugs. In this review, We briefly summarize pathophysiology of epilepsy and the mechanisms of antiepileptic drugs.
authors.affiliation: Department of Neurology, Fukushima Medical University School of Medicine.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Sugiura
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Ugawa
mesh_terms: D000927:Anticonvulsants / Q000494:pharmacology / Q000627:therapeutic use; D055724:Electrophysiological Phenomena / Q000235:genetics*; D004827:Epilepsy / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D007473:Ion Channels / Q000235:genetics* / Q000502:physiology*; D058990:Molecular Targeted Therapy; D009154:Mutation; D009474:Neurons / Q000502:physiology; D018079:Receptors, GABA / Q000502:physiology; D017470:Receptors, Glutamate / Q000502:physiology
chemical_list: D000927:Anticonvulsants; D007473:Ion Channels; D018079:Receptors, GABA; D017470:Receptors, Glutamate