title: In Vivo Hyperthermic Stress Model: An Easy Tool to Study the Effects of Oxidative Stress on Neuronal Tau Functionality in Mouse Brain.
abstract: Oxidative damage is an early event in neurodegenerative disorders such as Alzheimer disease. To increase oxidative stress in AD-related mouse models is essential to study early mechanisms involved in the physiopathology of these diseases. In this chapter, we describe an experimental mouse model of transient and acute hyperthermic stress to induce in vivo an increase of oxidative stress in the brain of any kind of wild-type or transgenic mouse.
authors.affiliation: Inserm, UMRS1172, JPARC, Alzheimer & Tauopathies, 1 rue Polonovski, 59045, Lille, France.
authors.forename: Alban
authors.initials: A
authors.lastname: Chauderlier
authors.affiliation: Inserm, UMRS1172, JPARC, Alzheimer & Tauopathies, 1 rue Polonovski, 59045, Lille, France.
authors.forename: Lucie
authors.initials: L
authors.lastname: Delattre
authors.affiliation: Inserm, UMRS1172, JPARC, Alzheimer & Tauopathies, 1 rue Polonovski, 59045, Lille, France.
authors.forename: Luc
authors.initials: L
authors.lastname: Buée
authors.affiliation: Inserm, UMRS1172, JPARC, Alzheimer & Tauopathies, 1 rue Polonovski, 59045, Lille, France. marie-christine.galas@inserm.fr.
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Galas
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology*; D004195:Disease Models, Animal; D006979:Hyperthermia, Induced; D051379:Mice; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000235:genetics / Q000502:physiology*; D016875:tau Proteins / Q000378:metabolism*
chemical_list: D016875:tau Proteins
keywords: Brain; Heat stress; Hyperthermic stress; Neuron; Oxidative stress; Tau