title: Nitric oxide donor hybrid compounds as promising anticancer agents.
abstract: Nitric oxide (NO) plays important roles in cardiovascular regulation, nerve transmission delivery and immune responses. In the last semicenturry, it has been proved that though low concentration of NO is tumor-promoting, high concentration of NO could exhibit multiple antitumor effects, which led to the research and development of kinds of NO donors and NO donor hybrid compounds as antitumor agents. Herein, the recent development of NO donor hybrid compounds is briefly reviewed.
authors.affiliation: Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University.
authors.forename: Qin-Ge
authors.initials: QG
authors.lastname: Ding
authors.forename: Jie
authors.initials: J
authors.lastname: Zang
authors.forename: Shuai
authors.initials: S
authors.lastname: Gao
authors.forename: Qianwen
authors.initials: Q
authors.lastname: Gao
authors.forename: Wenwen
authors.initials: W
authors.lastname: Duan
authors.forename: Xiaoyang
authors.initials: X
authors.lastname: Li
authors.forename: Wenfang
authors.initials: W
authors.lastname: Xu
authors.forename: Yingjie
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020030:Nitric Oxide Donors / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D020030:Nitric Oxide Donors