title: Imidazopyridyl compounds as aldosterone synthase inhibitors.
abstract: The inhibition of aldosterone synthase (CYP11B2) may be an effective treatment of hypertension and heart failure, among other ailments. Previously reported benzimidazole CYP11B2 inhibitors led the way for bioisosteric imidazopyridines that are both potent and selective over CYP11B1.
authors.affiliation: MRL, Rahway, NJ 07065, USA. Electronic address: brent.whitehead@merck.com.
authors.forename: Brent R
authors.initials: BR
authors.lastname: Whitehead
authors.affiliation: MRL, Rahway, NJ 07065, USA.
authors.forename: Michael M-C
authors.initials: MM
authors.lastname: Lo
authors.affiliation: MRL, Rahway, NJ 07065, USA.
authors.forename: Amjad
authors.initials: A
authors.lastname: Ali
authors.affiliation: MRL, Rahway, NJ 07065, USA.
authors.forename: Min K
authors.initials: MK
authors.lastname: Park
authors.affiliation: MRL, Rahway, NJ 07065, USA.
authors.forename: Scott B
authors.initials: SB
authors.lastname: Hoyt
authors.affiliation: MRL, Rahway, NJ 07065, USA.
authors.forename: Yusheng
authors.initials: Y
authors.lastname: Xiong
authors.affiliation: MRL, Newhouse, Lanarkshire ML1 5SH, United Kingdom.
authors.forename: Jiaqiang
authors.initials: J
authors.lastname: Cai
authors.affiliation: MRL, Newhouse, Lanarkshire ML1 5SH, United Kingdom.
authors.forename: Emma
authors.initials: E
authors.lastname: Carswell
authors.affiliation: MRL, Newhouse, Lanarkshire ML1 5SH, United Kingdom.
authors.forename: Andrew
authors.initials: A
authors.lastname: Cooke
authors.affiliation: MRL, Newhouse, Lanarkshire ML1 5SH, United Kingdom.
authors.forename: John
authors.initials: J
authors.lastname: MacLean
authors.affiliation: MRL, Newhouse, Lanarkshire ML1 5SH, United Kingdom.
authors.forename: Paul
authors.initials: P
authors.lastname: Ratcliffe
authors.affiliation: MRL, Newhouse, Lanarkshire ML1 5SH, United Kingdom.
authors.forename: John
authors.initials: J
authors.lastname: Robinson
authors.affiliation: MRL, Newhouse, Lanarkshire ML1 5SH, United Kingdom.
authors.forename: D Jonathan
authors.initials: DJ
authors.lastname: Bennett
authors.affiliation: MRL, Rahway, NJ 07065, USA.
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Clemas
authors.affiliation: MRL, Rahway, NJ 07065, USA.
authors.forename: Tom
authors.initials: T
authors.lastname: Wisniewski
authors.affiliation: MRL, Rahway, NJ 07065, USA.
authors.forename: Mary
authors.initials: M
authors.lastname: Struthers
authors.affiliation: MRL, Rahway, NJ 07065, USA.
authors.forename: Doris
authors.initials: D
authors.lastname: Cully
authors.affiliation: MRL, Rahway, NJ 07065, USA.
authors.forename: Douglas J
authors.initials: DJ
authors.lastname: MacNeil
mesh_terms: D000818:Animals; D003412:Cricetulus; D019405:Cytochrome P-450 CYP11B2 / Q000037:antagonists & inhibitors*; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D008253:Macaca mulatta; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D017208:Rats, Wistar; D013252:Steroid 11-beta-Hydroxylase / Q000037:antagonists & inhibitors; D013329:Structure-Activity Relationship
chemical_list: D007093:Imidazoles; D011725:Pyridines; D019405:Cytochrome P-450 CYP11B2; D013252:Steroid 11-beta-Hydroxylase
keywords: Aldosterone; CYP11B2; Heart failure; Hypertension; Imidazopyridine