title: Dual pH/redox responsive and CD44 receptor targeting hybrid nano-chrysalis based on new oligosaccharides of hyaluronan conjugates.
abstract: A smart hybrid microenvironment-mediated dual pH/redox-responsive polymeric nanoparticles combined with inorganic calcium phosphate (CaP) was fabricated, which we term as armored nano-chrysalis inspired by butterfly pupa. The nano-chrysalis has an inner core composed of specially designed oligosaccharides of hyaluronan (oHA) targeting CD44 receptor. The inner core has two functions, i.e., the dual pH/redox responsive polymeric conjugate and the fluorescent curcumin-prodrug function. The prepared nano-chrysalis possessed a smaller size (102.5±4.6nm) than the unarmored nano-chrysalis (122.5±6.6nm). Interestingly, while the nano-chrysalis were stable under pH 7.4, when incubated under the tumor acidic conditions (pH 6.5) the outer CaP armor would dissolve in a pH-dependent, sustained manner. Moreover, nano-chrysalis was demonstrated to present the most effective antitumor efficacy than other formulations. This study provides a promising smart nano-carrier platform to enhance the stability, decrease the side effects, and improve the therapeutic efficacy of anticancer drugs.
authors.affiliation: Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, School of Pharmacy, Yantai University, Yantai, 264005, PR China. Electronic address: cdq1981@126.com.
authors.forename: Daquan
authors.initials: D
authors.lastname: Chen
authors.affiliation: Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, School of Pharmacy, Yantai University, Yantai, 264005, PR China.
authors.forename: Xue
authors.initials: X
authors.lastname: Dong
authors.affiliation: Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, School of Pharmacy, Yantai University, Yantai, 264005, PR China.
authors.forename: Mengjiao
authors.initials: M
authors.lastname: Qi
authors.affiliation: Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, School of Pharmacy, Yantai University, Yantai, 264005, PR China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Song
authors.affiliation: Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, School of Pharmacy, Yantai University, Yantai, 264005, PR China.
authors.forename: Jingfang
authors.initials: J
authors.lastname: Sun
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry; D045744:Cell Line, Tumor; D016503:Drug Delivery Systems; D006801:Humans; D018960:Hyaluronan Receptors / Q000737:chemistry*; D006820:Hyaluronic Acid / Q000737:chemistry*; D008807:Mice, Inbred BALB C; D053758:Nanoparticles; D009844:Oligosaccharides / Q000737:chemistry*; D010084:Oxidation-Reduction
chemical_list: D000970:Antineoplastic Agents; D018960:Hyaluronan Receptors; D009844:Oligosaccharides; D006820:Hyaluronic Acid
keywords: Bioinspired prodrug; Dual pH/redox responsive; Multifunctional nanoparticles; Oligosaccharides of hyaluronan; Smart drug delivery