title: Ultrasensitive Luminescent In Vitro Detection for Tumor Markers Based on Inorganic Lanthanide Nano-Bioprobes.
abstract: Ultrasensitive and accurate detection of tumor markers is of vital importance for the screening or diagnosis of cancers at their early stages and for monitoring cancer relapse after surgical resection. Inorganic lanthanide (Ln3+) nanoparticles (NPs), owing to their superior physicochemical characteristics, are regarded as a new generation of luminescent nano-bioprobes in the field of cancer diagnosis and therapy. In this progress report, a focus is set on our recent efforts on the development of inorganic Ln3+-NPs as efficient luminescent nano-bioprobes for the ultrasensitive in vitro biodetection of tumor markers, with an emphasis on the dissolution-enhanced luminescent bioassay (DELBA), an emerging technique recently developed toward practical medical applications.
authors.affiliation: CAS Key Laboratory of Design and Assembly of Functional Nanostructures and State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences Fuzhou Fujian 350002 China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zheng
authors.affiliation: CAS Key Laboratory of Design and Assembly of Functional Nanostructures and State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences Fuzhou Fujian 350002 China.
authors.forename: Shanyong
authors.initials: S
authors.lastname: Zhou
authors.affiliation: CAS Key Laboratory of Design and Assembly of Functional Nanostructures and State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences Fuzhou Fujian 350002 China.
authors.forename: Jin
authors.initials: J
authors.lastname: Xu
authors.affiliation: CAS Key Laboratory of Design and Assembly of Functional Nanostructures and State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences Fuzhou Fujian 350002 China.
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Liu
authors.affiliation: CAS Key Laboratory of Design and Assembly of Functional Nanostructures and State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences Fuzhou Fujian 350002 China.
authors.forename: Ping
authors.initials: P
authors.lastname: Huang
authors.affiliation: CAS Key Laboratory of Design and Assembly of Functional Nanostructures and State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences Fuzhou Fujian 350002 China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: CAS Key Laboratory of Design and Assembly of Functional Nanostructures and State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences Fuzhou Fujian 350002 China.
authors.forename: Xueyuan
authors.initials: X
authors.lastname: Chen
keywords: dissolution‐enhanced luminescence; lanthanides; nano‐bioprobes; tumor markers; ultrasensitive bioassays