title: Review: Placental transport and metabolism of energy substrates in maternal obesity and diabetes.
abstract: Maternal obesity is growing in prevalence and is associated with increased morbidity and mortality for both mother and child. Women who are obese during pregnancy have a greater risk of metabolic complications such as gestational diabetes mellitus (GDM) as well as type 2 diabetes after pregnancy. Children of obese and/or GDM mothers have an increased susceptibility to congenital abnormalities and a range of cardio-metabolic disorders. The placenta is at the interface of the maternal and fetal environments and, its function per se, plays a major role in dictating the impact of maternal health on fetal development. Here, we review the literature on how placental function is affected in pregnancies complicated by obesity, and pre-gestational and gestational diabetes. The focus is on the availability of three key substrates in these conditions: glucose, lipids, and amino acids, and their impact on placental metabolic activity. Maternal obesity and diabetes are not always associated with fetal compromise and the adaptation of the placenta may partially determine the outcome. Understanding the differences in metabolic adaptation may open avenues for therapeutic development.
authors.affiliation: Mater Research Institute-The University of Queensland, Translational Research Institute, Woolloongabba, Australia; School of Biomedical Sciences, The University of Queensland, St Lucia, Queensland, Australia.
authors.forename: L A
authors.initials: LA
authors.lastname: Gallo
authors.affiliation: School of Medicine, The University of Queensland, Brisbane, Queensland, Australia; Obstetric Medicine, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia; The University of Queensland Centre for Clinical Research, Brisbane, Queensland, Australia.
authors.forename: H L
authors.initials: HL
authors.lastname: Barrett
authors.affiliation: The University of Queensland Centre for Clinical Research, Brisbane, Queensland, Australia; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia. Electronic address: m.dekker@uq.edu.au.
authors.forename: M
authors.initials: M
authors.lastname: Dekker Nitert
mesh_terms: D000596:Amino Acids / Q000378:metabolism; D016640:Diabetes, Gestational / Q000378:metabolism*; D004734:Energy Metabolism; D005260:Female; D005947:Glucose / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism; D009765:Obesity / Q000378:metabolism*; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy
chemical_list: D000596:Amino Acids; D005947:Glucose
keywords: Amino acids; Diabetes; Glucose; Lipid; Metabolism; Obesity; Placenta