title: Cerebral Rhizomucor Infection Treated by Posaconazole Delayed-Release Tablets in an Allogeneic Stem Cell Transplant Recipient.
abstract: Mucormycosis (zygomycosis) is an emerging fungal disease in allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients. A 30-year-old woman diagnosed with acute myelomonocytic leukemia and needing allo-HSCT presented pulmonary and cerebral infection due to Rhizomucor pusillus. This fungal infection was treated with surgical treatment and posaconazole delayed-release tablets. This strategy allowed reaching high drug levels that could not be obtained with the posaconazole solution.
authors.affiliation: Service of Infectious Diseases, Department of Medical Specialties, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil 4, 1211 Geneva 14, Switzerland. Electronic address: diego.andrey@hcuge.ch.
authors.forename: Diego O
authors.initials: DO
authors.lastname: Andrey
authors.affiliation: Service of Infectious Diseases, Department of Medical Specialties, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil 4, 1211 Geneva 14, Switzerland.
authors.forename: Laurent
authors.initials: L
authors.lastname: Kaiser
authors.affiliation: Service of Infectious Diseases, Department of Medical Specialties, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil 4, 1211 Geneva 14, Switzerland.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Emonet
authors.affiliation: Service of Infectious Diseases, Hôpital Fribourgeois, Chemin des Pensionnats 2, 1708 Fribourg, Switzerland.
authors.forename: Veronique
authors.initials: V
authors.lastname: Erard
authors.affiliation: Service of Hematology, Department of Medical Specialties, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil 4, 1211 Geneva 14, Switzerland.
authors.forename: Yves
authors.initials: Y
authors.lastname: Chalandon
authors.affiliation: Service of Infectious Diseases, Department of Medical Specialties, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil 4, 1211 Geneva 14, Switzerland.
authors.forename: Christian
authors.initials: C
authors.lastname: van Delden
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D003692:Delayed-Action Preparations; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D015479:Leukemia, Myelomonocytic, Acute / Q000276:immunology / Q000601:surgery*; D009091:Mucormycosis / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology*; D020103:Rhizomucor / Q000187:drug effects; D033581:Stem Cell Transplantation; D013607:Tablets; D014184:Transplantation, Homologous; D014230:Triazoles / Q000627:therapeutic use*
chemical_list: D000935:Antifungal Agents; D003692:Delayed-Action Preparations; D013607:Tablets; D014230:Triazoles; C101425:posaconazole
keywords: Mucormycosis; Posaconazole delayed-release tablets; Rhizomucor pusillus; Zygomycosis