title: Carotid intima-media thickness and arterial stiffness as early markers of atherosclerosis in pediatric celiac disease.
abstract: The association between pediatric celiac disease (CD) and atherosclerosis is unknown. Our aim was to investigate whether pediatric CD patients have an increased risk of atherosclerosis. We evaluated the premature atherosclerosis by pulse wave velocity (PWV) and carotid intima-media thickness (cIMT). A total of 37 CD patients (20 girls, mean age 13±3.3 years) and 36 healthy age and sex matched controls were enrolled. Mean duration of CD was 47.1±32.3 months and 40.5% of patients had positive tissue transglutaminase antibody (tTg) IgA. Total cholesterol level was lower in CD (p=0.026) and cIMT was lower in tTg IgA antibody negative CD (p=0.030). cIMT was significantly correlated with tTg IgA antibody positivity (r=0.336; p=0.042). Adherence to strict gluten-free diet is associated with decreased cIMT, suggesting that gluten withdrawal seems to have a beneficial effect on premature atherosclerosis.
authors.affiliation: Division of Pediatric Gastroenterology, Department of Pediatrics, Ankara University Faculty of Medicine, Ankara, Turkey.
authors.forename: Arzu Meltem
authors.initials: AM
authors.lastname: Demir
authors.affiliation: Division of Pediatric Gastroenterology, Department of Pediatrics, Ankara University Faculty of Medicine, Ankara, Turkey.
authors.forename: Zarife
authors.initials: Z
authors.lastname: Kuloğlu
authors.affiliation: Division of Pediatric Gastroenterology, Department of Pediatrics, Ankara University Faculty of Medicine, Ankara, Turkey.
authors.forename: Aytaç
authors.initials: A
authors.lastname: Yaman
authors.affiliation: Department of Radiology, Ankara University Faculty of Medicine, Ankara, Turkey.
authors.forename: Suat
authors.initials: S
authors.lastname: Fitöz
authors.affiliation: Department of Nephrology, Ankara University Faculty of Medicine, Ankara, Turkey.
authors.forename: Gökhan
authors.initials: G
authors.lastname: Nergizoğlu
authors.affiliation: Division of Pediatric Gastroenterology, Department of Pediatrics, Ankara University Faculty of Medicine, Ankara, Turkey.
authors.forename: Aydan
authors.initials: A
authors.lastname: Kansu
mesh_terms: D000293:Adolescent; D050197:Atherosclerosis / Q000150:complications / Q000175:diagnosis*; D015415:Biomarkers / Q000032:analysis*; D059168:Carotid Intima-Media Thickness; D002446:Celiac Disease / Q000150:complications / Q000175:diagnosis*; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies; D063177:Pulse Wave Analysis; D059289:Vascular Stiffness
chemical_list: D015415:Biomarkers
keywords: atherosclerosis; carotid intima media thickness; celiac disease; children; pulse wave velocity