title: Triglyceride content in remnant lipoproteins is significantly increased after food intake and is associated with plasma lipoprotein lipase.
abstract: BACKGROUND
  Previous large population studies reported that non-fasting plasma triglyceride (TG) reflect a higher risk for cardiovascular disease than TG in the fasting plasma. This is suggestive of the presence of higher concentration of remnant lipoproteins (RLP) in postprandial plasma.
  
  
  METHODS
  TG and RLP-TG together with other lipids, lipoproteins and lipoprotein lipase (LPL) in both fasting and postprandial plasma were determined in generally healthy volunteers and in patients with coronary artery disease (CAD) after consuming a fat load or a more typical moderate meal.
  
  
  RESULTS
  RLP-TG/TG ratio (concentration) and RLP-TG/RLP-C ratio (particle size) were significantly increased in the postprandial plasma of both healthy controls and CAD patients compared with those in fasting plasma. LPL/RLP-TG ratio demonstrated the interaction correlation between RLP concentration and LPL activity The increased RLP-TG after fat consumption contributed to approximately 90% of the increased plasma TG, while approximately 60% after a typical meal. Plasma LPL in postprandial plasma was not significantly altered after either type of meal.
  
  
  CONCLUSIONS
  Concentrations of RLP-TG found in the TG along with its particle size are significantly increased in postprandial plasma compared with fasting plasma. Therefore, non-fasting TG determination better reflects the presence of higher RLP concentrations in plasma.
authors.affiliation: Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan; Hidaka Hospital, Takasaki, Japan; General Internal Medicine, Kanazawa Medical University, Kanazawa, Japan; Laboratory of Clinical Nutrition and Medicine, Kagawa Nutrition University, Tokyo, Japan; Department of Molecular Biosciences, School of Veterinary Medicine and Department of Nutrition, University of California, Davis, CA, USA. Electronic address: nakajimak05@ybb.ne.jp.
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Nakajima
authors.affiliation: Department of Laboratory Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Tokita
authors.affiliation: Hidaka Hospital, Takasaki, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Sakamaki
authors.affiliation: Hidaka Hospital, Takasaki, Japan.
authors.forename: Younosuke
authors.initials: Y
authors.lastname: Shimomura
authors.affiliation: General Internal Medicine, Kanazawa Medical University, Kanazawa, Japan.
authors.forename: Junji
authors.initials: J
authors.lastname: Kobayashi
authors.affiliation: Laboratory of Clinical Nutrition and Medicine, Kagawa Nutrition University, Tokyo, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Kamachi
authors.affiliation: Laboratory of Clinical Nutrition and Medicine, Kagawa Nutrition University, Tokyo, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Tanaka
authors.affiliation: Department of Molecular Biosciences, School of Veterinary Medicine and Department of Nutrition, University of California, Davis, CA, USA.
authors.forename: Kimber L
authors.initials: KL
authors.lastname: Stanhope
authors.affiliation: Department of Molecular Biosciences, School of Veterinary Medicine and Department of Nutrition, University of California, Davis, CA, USA.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Havel
authors.affiliation: Otsuka Pharmaceutical Development & Commercialization, Inc., Princeton, NJ, USA.
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.affiliation: Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Machida
authors.affiliation: Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.
authors.forename: Masami
authors.initials: M
authors.lastname: Murakami
mesh_terms: D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000097:blood*; D016022:Case-Control Studies; D004435:Eating / Q000502:physiology*; D005215:Fasting / Q000097:blood; D005260:Female; D006801:Humans; D008071:Lipoprotein Lipase / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010316:Particle Size; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood*
chemical_list: D008074:Lipoproteins; D014280:Triglycerides; C548261:LPL protein, human; D008071:Lipoprotein Lipase
keywords: Fasting and postprandial plasma; Food intake (fat load); Hepatic triglyceride lipase (HTGL); Lipoprotein lipase (LPL); RLP-C; RLP-TG; Remnant lipoproteins (RLP); Triglycerides (TG)