title: Reduced serum levels of oestradiol and brain derived neurotrophic factor in both diabetic women and HFD-feeding female mice.
abstract: The estrogen levels in the pre and post menstrual phases interact with brain-derived neurotrophic factor in a complex manner, which influences the overall state of the body. To study the role of oestradiol and brain-derived neurotrophic factor in modulating obesity related type 2 diabetes and the interactions between two factors, we enrolled 15 diabetic premenopausal women and 15 diabetic postmenopausal women respectively, the same number of healthy pre and postmenopausal women were recruited as two control groups. The fasting blood glucose, insulin, lipids, estrogen, and brain-derived neurotrophic factor levels were measured through clinical tests. Additionally, we set up obese female mouse model to mimic human trial stated above, to verify the relationship between estrogen and brain-derived neurotrophic factor. Our findings revealed that there is a moderately positive correlation between brain-derived neurotrophic factor and oestradiol in females, and decreased brain-derived neurotrophic factor may worsen impaired insulin function. The results further confirmed that high fat diet-fed mice which exhibited impaired glucose tolerance, showed lower levels of oestradiol and decreased expression of brain-derived neurotrophic factor mRNA in the ventromedial hypothalamus. The level of brain-derived neurotrophic factor reduced on condition that the level of oestradiol is sufficiently low, such as women in postmenopausal period, which aggravates diabetes through feeding-related pathways. Increasing the level of brain-derived neurotrophic factor may help to alleviate the progression of the disease in postmenopausal women with diabetes.
authors.affiliation: Quanzhou first Hospital, Fujian Medical University, Fuzhou, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, Southwest Hospital, Third Military Medical University, Chongqing, China.
authors.forename: Shan-Wen
authors.initials: SW
authors.lastname: Zhang
authors.affiliation: Neurological Diseases Division, Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, NSW, 2010, Australia.
authors.forename: Neeta
authors.initials: N
authors.lastname: Khandekar
authors.affiliation: Department of Cardiology, Southwest Hospital, Third Military Medical University, Chongqing, China.
authors.forename: Shi-Fei
authors.initials: SF
authors.lastname: Tong
authors.affiliation: Department of Cardiology, Southwest Hospital, Third Military Medical University, Chongqing, China.
authors.forename: He-Qin
authors.initials: HQ
authors.lastname: Yang
authors.affiliation: Quanzhou first Hospital, Fujian Medical University, Fuzhou, China.
authors.forename: Wan-Ru
authors.initials: WR
authors.lastname: Wang
authors.affiliation: School of Medicine, University of Wollongong and Illawarra Health and Medical Research Institute, Wollongong, NSW, 2522, Australia.
authors.forename: Xu-Feng
authors.initials: XF
authors.lastname: Huang
authors.affiliation: Department of Cardiology, Southwest Hospital, Third Military Medical University, Chongqing, China. zysong2010@126.com.
authors.forename: Zhi-Yuan
authors.initials: ZY
authors.lastname: Song
authors.affiliation: Department of Cardiology, Southwest Hospital, Third Military Medical University, Chongqing, China. shulin1956@126.com.|Neurological Diseases Division, Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, NSW, 2010, Australia. shulin1956@126.com.
authors.forename: Shu
authors.initials: S
authors.lastname: Lin
mesh_terms: D000818:Animals; D001786:Blood Glucose; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D059305:Diet, High-Fat; D004958:Estradiol / Q000097:blood*; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D051379:Mice; D009765:Obesity / Q000097:blood
chemical_list: D001786:Blood Glucose; D019208:Brain-Derived Neurotrophic Factor; D007328:Insulin; D004958:Estradiol
keywords: Brain derived neurotrophic factor; Obesity and diabetes; Oestradiol