title: Review of Adaptive Programmable Materials and Their Bioapplications.
abstract: Adaptive programmable materials have attracted increasing attention due to their high functionality, autonomous behavior, encapsulation, and site-specific confinement capabilities in various applications. Compared to conventional materials, adaptive programmable materials possess unique single-material architecture that can maintain, respond, and change their shapes and dimensions when they are subjected to surrounding environment changes, such as alternation in temperature, pH, and ionic strength. In this review, the most-recent advances in the design strategies of adaptive programmable materials are presented with respect to different types of architectural polymers, including stimuli-responsive polymers and shape-memory polymers. The diverse functions of these sophisticated materials and their significance in therapeutic agent delivery systems are also summarized in this review. Finally, the challenges for facile fabrication of these materials and future prospective are also discussed.
authors.affiliation: School of Chemistry and Chemical Engineering, Henan Normal University , Henan 453007, China.
authors.forename: Xiaoshan
authors.initials: X
authors.lastname: Fan
authors.affiliation: Department of Materials Science and Engineering, National University of Singapore , 9 Engineering Drive 1, 117576 Singapore.
authors.forename: Jing Yang
authors.initials: JY
authors.lastname: Chung
authors.affiliation: Department of Materials Science and Engineering, National University of Singapore , 9 Engineering Drive 1, 117576 Singapore.
authors.forename: Yong Xiang
authors.initials: YX
authors.lastname: Lim
authors.affiliation: Institute of Materials Research and Engineering (IMRE), A*STAR , 2 Fusionopolis Way, Innovis, no. 08-03, 138634 Singapore.
authors.forename: Zibiao
authors.initials: Z
authors.lastname: Li
authors.affiliation: Institute of Materials Research and Engineering (IMRE), A*STAR , 2 Fusionopolis Way, Innovis, no. 08-03, 138634 Singapore.|Department of Materials Science and Engineering, National University of Singapore , 9 Engineering Drive 1, 117576 Singapore.|Singapore Eye Research Institute , 11 Third Hospital Avenue, 168751 Singapore.
authors.forename: Xian Jun
authors.initials: XJ
authors.lastname: Loh
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D004364:Pharmaceutical Preparations; D011108:Polymers
chemical_list: D001672:Biocompatible Materials; D004364:Pharmaceutical Preparations; D011108:Polymers
keywords: adaptive programmable; drug delivery; patterned film; shape memory; stressed bilayer