title: Regulation, evolution and consequences of cotranslational protein complex assembly.
abstract: Most proteins assemble into complexes, which are involved in almost all cellular processes. Thus it is crucial for cell viability that mechanisms for correct assembly exist. The timing of assembly plays a key role in determining the fate of the protein: if the protein is allowed to diffuse into the crowded cellular milieu, it runs the risk of forming non-specific interactions, potentially leading to aggregation or other deleterious outcomes. It is therefore expected that strong regulatory mechanisms should exist to ensure efficient assembly. In this review we discuss the cotranslational assembly of protein complexes and discuss how it occurs, ways in which it is regulated, potential disadvantages of cotranslational interactions between proteins and the implications for the inheritance of dominant-negative genetic disorders.
authors.affiliation: Department of Chemistry, University of Oxford, 12 Mansfield Rd, Oxford OX1 3TA, UK. Electronic address: eviatarhj@gmail.com.
authors.forename: Eviatar
authors.initials: E
authors.lastname: Natan
authors.affiliation: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
authors.forename: Jonathan N
authors.initials: JN
authors.lastname: Wells
authors.affiliation: Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
authors.forename: Sarah A
authors.initials: SA
authors.lastname: Teichmann
authors.affiliation: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK. Electronic address: joseph.marsh@igmm.ed.ac.uk.
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Marsh
mesh_terms: D000818:Animals; D004194:Disease / Q000235:genetics; D019143:Evolution, Molecular; D006801:Humans; D009876:Operon / Q000235:genetics; D014176:Protein Biosynthesis; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D011506:Proteins