title: Systemic Immune Response to Vaccination on FDG-PET/CT.
abstract: A patient with newly diagnosed right lung cancer had transient18F-fluorodeoxyglucose (FDG)-avid left axillary lymph nodes and intense splenic FDG uptake on positron emission tomography (PET)/computed tomography (CT). History revealed that the patient received a left-sided influenza vaccine 2-3 days before the examination. Although inflammatory FDG uptake in ipsilateral axillary nodes is reported, to our knowledge, this is the first report of visualization of the systemic immune response in the spleen related to the influenza vaccination on FDG-PET/CT. The history, splenic uptake and time course on serial FDG-PET/CT helped to avoid a false-positive interpretation for progressing lung cancer and alteration of the radiation therapy plan.
authors.affiliation: Department of Imaging, Dana-Farber Cancer Institute and Department of Radiology, Brigham and Women's Hospital, 450 Brookline Avenue, Boston, MA 02215 USA.
authors.forename: Mark
authors.initials: M
authors.lastname: Mingos
authors.affiliation: Department of Imaging, Dana-Farber Cancer Institute and Department of Radiology, Brigham and Women's Hospital, 450 Brookline Avenue, Boston, MA 02215 USA.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Howard
authors.affiliation: Department of Radiation Oncology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115 USA.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Giacalone
authors.affiliation: Department of Radiation Oncology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115 USA.
authors.forename: David
authors.initials: D
authors.lastname: Kozono
authors.affiliation: Department of Imaging, Dana-Farber Cancer Institute and Department of Radiology, Brigham and Women's Hospital, 450 Brookline Avenue, Boston, MA 02215 USA.
authors.forename: Heather
authors.initials: H
authors.lastname: Jacene
keywords: FDG; FDG-PET/CT; Immunization; Lung cancer; Spleen; Vaccine