title: Intracerebral microdialysis in blood-brain barrier drug research with focus on nanodelivery.
abstract: Microdialysis has contributed significantly to advance the understanding of BBB transport of drugs and to reveal key aspects of BBB transport, including quantifying active efflux and active uptake. Microdialysis studies on pharmacokinetic-pharmacodynamic relationships have given in-depth understanding of the processes involved. Recently, nanodelivery to the brain has been investigated with microdialysis, contributing to nanodelivery science by giving quantitative information on the possible success of different delivery vehicles and how they are involved in BBB transport.
authors.affiliation: Translational Pharmacokinetics-Pharmacodynamics Group, Department of Pharmaceutical Biosciences, Uppsala University, Sweden. Electronic address: mhu@farmbio.uu.se.
authors.forename: Margareta
authors.initials: M
authors.lastname: Hammarlund-Udenaes
mesh_terms: D000818:Animals; D035843:Biomedical Research; D001812:Blood-Brain Barrier / Q000378:metabolism*; D055808:Drug Discovery; D006801:Humans; D017551:Microdialysis; D036103:Nanotechnology; D010599:Pharmacokinetics