title: Metal-Catalyzed Asymmetric Michael Addition in Natural Product Synthesis.
abstract: Asymmetric catalysis for chiral compound synthesis is a rapidly growing field in modern organic chemistry. Asymmetric catalytic processes have been indispensable for the synthesis of enantioselective materials to meet demands from various fields. Michael addition has been used extensively for the construction of C-C bonds under mild conditions. With the discovery and development of organo- and metal-catalyzed asymmetric Michael additions, the synthesis of enantioselective and/or diastereoselective Michael adducts has become possible and increasingly prevalent in the literature. In particular, metal-catalyzed asymmetric Michael addition has been employed as a key reaction in natural product synthesis for the construction of contiguous quaternary stereogenic center(s), which is still a difficult task in organic synthesis. Previously reported applications of metal-catalyzed asymmetric Michael additions in natural product synthesis are presented here and discussed in depth.
authors.affiliation: Department of Chemistry, South University of Science and Technology of China, No. 1088 Xueyuan Ave., Nanshan District, Shenzhen, Guangdong, 518055, P. R. China.
authors.forename: Chunngai
authors.initials: C
authors.lastname: Hui
authors.affiliation: Department of Chemistry, South University of Science and Technology of China, No. 1088 Xueyuan Ave., Nanshan District, Shenzhen, Guangdong, 518055, P. R. China.
authors.forename: Fan
authors.initials: F
authors.lastname: Pu
authors.affiliation: Department of Chemistry, South University of Science and Technology of China, No. 1088 Xueyuan Ave., Nanshan District, Shenzhen, Guangdong, 518055, P. R. China.
authors.forename: Jing
authors.identifier: http://orcid.org/0000-0002-5304-7350
authors.initials: J
authors.lastname: Xu
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis*; D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D008670:Metals / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D001688:Biological Products; D008670:Metals
keywords: asymmetric Michael addition; metal catalysis; natural product; total synthesis