title: Nephroblastoma Arising from Primary Testicular Germ Cell Tumor: A Case Report and Literature Review.
abstract: Adult extrarenal nephroblastoma is a very rare tumor. Nephroblastoma arising from primary testicular germ cell tumor is exceedingly rare. To our knowledge, only three cases have been reported in the English literature. We report a case of a 19-year-old man who presented with a large right testicle. Image studies showed a large retroperitoneal mass along with liver and lung metastases. Orchiectomy demonstrated a mixed germ cell tumor composed of yolk sac tumor, embryonal carcinoma, and mature and immature teratoma with a significant portion of nephroblastoma. The patient received chemotherapy and no recurrence was noted during six months of followup. WT-1 expression was also studied due to the lack of consistency of its expression in testicular nephroblastoma in the literature. We also present a discussion and review of the literature due to its rarity, which indicate an adverse prognosis for patients with nephroblastoma components receiving standard chemotherapeutical regimes for testicular germ cell tumors.
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Louisville School of Medicine, Louisville, KY, USA.
authors.forename: Houda
authors.initials: H
authors.lastname: Alatassi
authors.affiliation: Department of Urology, University of Louisville School of Medicine, Louisville, KY, USA.
authors.forename: Brittany E
authors.initials: BE
authors.lastname: O'Bryan
authors.affiliation: Department of Urology, University of Louisville School of Medicine, Louisville, KY, USA.
authors.forename: Jamie C
authors.initials: JC
authors.lastname: Messer
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Louisville School of Medicine, Louisville, KY, USA.
authors.forename: Zhenglong
authors.identifier: 0000-0002-6508-989X
authors.initials: Z
authors.lastname: Wang