title: The Effect of Cage Shape on Nanoparticle-Based Drug Carriers: Anticancer Drug Release and Efficacy via Receptor Blockade Using Dextran-Coated Iron Oxide Nanocages.
abstract: Although a range of nanoparticles have been developed as drug delivery systems in cancer therapeutics, this approach faces several important challenges concerning nanocarrier circulation, clearance, and penetration. The impact of reducing nanoparticle size on penetration through leaky blood vessels around tumor microenvironments via enhanced permeability and retention (EPR) effect has been extensively examined. Recent research has also investigated the effect of nanoparticle shape on circulation and target binding affinity. However, how nanoparticle shape affects drug release and therapeutic efficacy has not been previously explored. Here, we compared the drug release and efficacy of iron oxide nanoparticles possessing either a cage shape (IO-NCage) or a solid spherical shape (IO-NSP). Riluzole cytotoxicity against metastatic cancer cells was enhanced 3-fold with IO-NCage. The shape of nanoparticles (or nanocages) affected the drug release point and cellular internalization, which in turn influenced drug efficacy. Our study provides evidence that the shape of iron oxide nanoparticles has a significant impact on drug release and efficacy.
authors.affiliation: Department of Chemistry, Hunter College, City University of New York , 695 Park Avenue, New York, New York 10065, United States.
authors.forename: Sham
authors.initials: S
authors.lastname: Rampersaud
authors.affiliation: Department of Chemistry, Hunter College, City University of New York , 695 Park Avenue, New York, New York 10065, United States.|Department of Chemistry, The Graduate Center of City University of New York , 365 Fifth Avenue, New York, New York 10016, United States.
authors.forename: Justin
authors.initials: J
authors.lastname: Fang
authors.affiliation: Department of Chemistry, Hunter College, City University of New York , 695 Park Avenue, New York, New York 10065, United States.|Department of Chemistry, The Graduate Center of City University of New York , 365 Fifth Avenue, New York, New York 10016, United States.
authors.forename: Zengyan
authors.initials: Z
authors.lastname: Wei
authors.affiliation: Department of Chemistry, Hunter College, City University of New York , 695 Park Avenue, New York, New York 10065, United States.
authors.forename: Kristina
authors.initials: K
authors.lastname: Fabijanic
authors.affiliation: Department of Medical Laboratory Sciences, Hunter College, City University of New York , 425 East 25th Street, New York, New York 10010, United States.
authors.forename: Stefan
authors.initials: S
authors.lastname: Silver
authors.affiliation: Department of Medical Laboratory Sciences, Hunter College, City University of New York , 425 East 25th Street, New York, New York 10010, United States.
authors.forename: Trisha
authors.initials: T
authors.lastname: Jaikaran
authors.affiliation: Department of Medical Laboratory Sciences, Hunter College, City University of New York , 425 East 25th Street, New York, New York 10010, United States.
authors.forename: Yuleisy
authors.initials: Y
authors.lastname: Ruiz
authors.affiliation: Department of Medical Laboratory Sciences, Hunter College, City University of New York , 425 East 25th Street, New York, New York 10010, United States.
authors.forename: Murielle
authors.initials: M
authors.lastname: Houssou
authors.affiliation: Department of Chemistry, Hunter College, City University of New York , 695 Park Avenue, New York, New York 10065, United States.|Department of Chemistry, The Graduate Center of City University of New York , 365 Fifth Avenue, New York, New York 10016, United States.
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Yin
authors.affiliation: Department of Chemistry, Hunter College, City University of New York , 695 Park Avenue, New York, New York 10065, United States.|Department of Chemistry, The Graduate Center of City University of New York , 365 Fifth Avenue, New York, New York 10016, United States.
authors.forename: Shengping
authors.initials: S
authors.lastname: Zheng
authors.affiliation: Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine , New York, New York 10021, United States.|Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo , Tokyo 113-8655, Japan.
authors.forename: Ayako
authors.initials: A
authors.lastname: Hashimoto
authors.affiliation: Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine , New York, New York 10021, United States.
authors.forename: Ayuko
authors.initials: A
authors.lastname: Hoshino
authors.affiliation: Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine , New York, New York 10021, United States.
authors.forename: David
authors.initials: D
authors.lastname: Lyden
authors.affiliation: Department of Medical Laboratory Sciences, Hunter College, City University of New York , 425 East 25th Street, New York, New York 10010, United States.
authors.forename: Shahana
authors.initials: S
authors.lastname: Mahajan
authors.affiliation: Department of Chemistry, Hunter College, City University of New York , 695 Park Avenue, New York, New York 10065, United States.|Department of Chemistry, The Graduate Center of City University of New York , 365 Fifth Avenue, New York, New York 10016, United States.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Matsui
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage; D045744:Cell Line, Tumor; D003911:Dextrans; D004337:Drug Carriers; D005290:Ferric Compounds; D006801:Humans; D053758:Nanoparticles; D019782:Riluzole / Q000008:administration & dosage
chemical_list: D000970:Antineoplastic Agents; D003911:Dextrans; D004337:Drug Carriers; D005290:Ferric Compounds; C000499:ferric oxide; D019782:Riluzole
keywords: Nanoparticles; cancer; drug delivery; nanocage; nanoparticle shape