title: Divergent topological architecture of the default mode network as a pretreatment predictor of early antidepressant response in major depressive disorder.
abstract: Identifying a robust pretreatment neuroimaging marker would be helpful for the selection of an optimal therapy for major depressive disorder (MDD). We recruited 82 MDD patients [n = 42 treatment-responsive depression (RD) and n = 40 non-responding depression (NRD)] and 50 healthy controls (HC) for this study. Based on the thresholded partial correlation matrices of 58 specific brain regions, a graph theory approach was applied to analyse the topological properties. When compared to HC, both RD and NRD patients exhibited a lower nodal degree (Dnodal) in the left anterior cingulate gyrus; as for RD, the Dnodalof the left superior medial orbitofrontal gyrus was significantly reduced, but the right inferior orbitofrontal gyrus was increased (all P < 0.017, FDR corrected). Moreover, the nodal degree in the right dorsolateral superior frontal cortex (SFGdor) was significantly lower in RD than in NRD. Receiver operating characteristic curve analysis demonstrated that the λ and nodal degree in the right SFGdor exhibited a good ability to distinguish nonresponding patients from responsive patients, which could serve as a specific maker to predict an early response to antidepressants. The disrupted topological configurations in the present study extend the understanding of pretreatment neuroimaging predictors for antidepressant medication.
authors.affiliation: Department of Psychosomatics &Psychiatry, Institute of Psychosomatics, Zhongda Hospital, Medical School of Southeast University, Nanjing 210009, China.|Department of Psychiatry, Affiliated Wuhu NO.4 Hospital of Shanghai Jiaotong University BIO-X center, Wuhu 241001, China.
authors.forename: Zhenghua
authors.initials: Z
authors.lastname: Hou
authors.affiliation: Department of Neurology, Institute of Neuropsychology, Zhongda Hospital, Medical School of Southeast University, Nanjing 210009, China.
authors.forename: Zan
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Psychosomatics &Psychiatry, Institute of Psychosomatics, Zhongda Hospital, Medical School of Southeast University, Nanjing 210009, China.
authors.forename: Wenhao
authors.initials: W
authors.lastname: Jiang
authors.affiliation: Department of Psychosomatics &Psychiatry, Institute of Psychosomatics, Zhongda Hospital, Medical School of Southeast University, Nanjing 210009, China.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Yin
authors.affiliation: Department of Psychosomatics &Psychiatry, Institute of Psychosomatics, Zhongda Hospital, Medical School of Southeast University, Nanjing 210009, China.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Yue
authors.affiliation: Department of Psychosomatics &Psychiatry, Institute of Psychosomatics, Zhongda Hospital, Medical School of Southeast University, Nanjing 210009, China.
authors.forename: Yuqun
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China.
authors.forename: Xiaopeng
authors.initials: X
authors.lastname: Song
authors.affiliation: Department of Psychosomatics &Psychiatry, Institute of Psychosomatics, Zhongda Hospital, Medical School of Southeast University, Nanjing 210009, China.
authors.forename: Yonggui
authors.initials: Y
authors.lastname: Yuan
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use*; D001931:Brain Mapping / Q000379:methods*; D016022:Case-Control Studies; D003865:Major Depressive Disorder / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006179:Gyrus Cinguli / Q000000981:diagnostic imaging* / Q000187:drug effects / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways; D017397:Prefrontal Cortex / Q000000981:diagnostic imaging* / Q000187:drug effects / Q000503:physiopathology
chemical_list: D000928:Antidepressive Agents