title: Multifunctional Polymeric Platform of Magnetic Ferrite Colloidal Superparticles for Luminescence, Imaging, and Hyperthermia Applications.
abstract: Adequately designed multiresponsive water-soluble graft copolymers were used to serve as a multifunctional polymeric platform for the encapsulation and transfer in aqueous media of hydrophobic magnetic nanoparticles (MNPs). The backbone of the graft copolymers was composed of hydrophilic sodium methacrylate units, hydrophobic dodecyl methacrylate units, and luminescent quinoline-based units, while either the homopolymer poly(N-isopropylacrylamide) or a poly(N,N-dimethylacrylamide-co-N-isopropylacrylamide) copolymer was used as thermosensitive pendent side chains. The polymeric platform forms micellar-type assemblies in aqueous solution, and exhibits pH-responsive luminescent properties and a lower critical solution temperature behavior in water. Depending on the design of the side chains, the cloud point temperatures were determined at 38 and 42 °C, close or slightly above body temperature (37 °C). Above the critical micelle concentration (CMC), both graft copolymers can effectively stabilize in aqueous media as magnetic colloidal superparticles (MSPs), oleylamine-coated MnFe2O4MNPs, as well as 1:1 mixture of oleylamine-coated MnFe2O4and CoFe2O4MNPs. When CoFe2O4particles were mixed with MnFeO4in equal amounts, the specific loss power increased significantly, while an opposite trend was observed in the magnetic resonance imaging (MRI) studies, probably due to the anisotropy of cobalt. As a consequence, fine-tuning of the chemical structure of the copolymers and the composition of the MSPs can lead to materials that are able to act simultaneously as luminescent, hyperthermia, and contrast MRI agents.
authors.affiliation: Department of Chemistry, University of Patras , GR-26504 Patras, Greece.
authors.forename: Zacharoula
authors.initials: Z
authors.lastname: Iatridi
authors.affiliation: Department of Chemistry, Aristotle University of Thessaloniki , GR-54124 Thessaloniki, Greece.
authors.forename: Kosmas
authors.initials: K
authors.lastname: Vamvakidis
authors.affiliation: Department of Medical Physics, University Hospital of Larissa, University of Thessaly, Biopolis , GR-41110 Larisa, Greece.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Tsougos
authors.affiliation: Department of Radiology, University Hospital of Larissa, University of Thessaly, Biopolis , GR-41110 Larisa, Greece.
authors.forename: Katerina
authors.initials: K
authors.lastname: Vassiou
authors.affiliation: Department of Chemistry, Aristotle University of Thessaloniki , GR-54124 Thessaloniki, Greece.
authors.forename: Catherine
authors.initials: C
authors.lastname: Dendrinou-Samara
authors.affiliation: Department of Chemistry, University of Patras , GR-26504 Patras, Greece.|FORTH/ICE-HT , Stadiou Street, P.O. Box 1414, GR-26504 Rio-Patras, Greece.
authors.forename: Georgios
authors.identifier: http://orcid.org/0000-0003-0893-4716
authors.initials: G
authors.lastname: Bokias
mesh_terms: D005290:Ferric Compounds / Q000737:chemistry*; D006979:Hyperthermia, Induced; D049449:Luminescence; D009682:Magnetic Resonance Spectroscopy; D008823:Micelles; D011108:Polymers; D013696:Temperature
chemical_list: D005290:Ferric Compounds; D008823:Micelles; D011108:Polymers; C001215:ferrite
keywords: graft copolymers; hydrophobically modified water-soluble polymers; hyperthermia; luminescent labeling; magnetic nanoparticles; magnetic resonance imaging; poly(N-isopropylacrylamide)