title: p53 as a Regulator of Lipid Metabolism in Cancer.
abstract: Enhanced proliferation and survival are common features of cancer cells. Cancer cells are metabolically reprogrammed which aids in their survival in nutrient-poor environments. Indeed, changes in metabolism of glucose and glutamine are essential for tumor progression. Thus, metabolic reprogramming is now well accepted as a hallmark of cancer. Recent findings suggest that reprogramming of lipid metabolism also occurs in cancer cells, since lipids are used for biosynthesis of membranes, post-translational modifications, second messengers for signal transduction, and as a source of energy during nutrient deprivation. The tumor suppressor p53 is a transcription factor that controls the expression of proteins involved in cell cycle arrest, DNA repair, apoptosis, and senescence. p53 also regulates cellular metabolism, which appears to play a key role in its tumor suppressive activities. In this review article, we summarize non-canonical functions of wild-type and mutant p53 on lipid metabolism and discuss their association with cancer progression.
authors.affiliation: Department of Cancer Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA. aparrales@kumc.edu.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Parrales
authors.affiliation: Department of Cancer Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA. tiwakuma@kumc.edu.
authors.forename: Tomoo
authors.initials: T
authors.lastname: Iwakuma
mesh_terms: D000818:Animals; D006801:Humans; D050356:Lipid Metabolism; D050505:Mutant Proteins / Q000378:metabolism; D009363:Neoplasm Proteins / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: D050505:Mutant Proteins; D009363:Neoplasm Proteins; D016159:Tumor Suppressor Protein p53
keywords: cancer; fatty acid oxidation; lipid metabolism; mevalonate pathway; p53