title: Synthesis of Functionalized 6-Hydroxy-2-oxindole Derivatives by Phenoxide Cyclization.
abstract: An apparent intramolecular cross-dehydrogenative coupling of N-(3-hydroxy)monoanilide of maleic esters comprising base promoted phenoxide cyclization and subsequent base-mediated aerobic oxidation was developed to synthesize a variety of 2-(6-hydroxy-2-oxoindolin-3-ylidene)acetate derivatives. The isolation of intermediate cyclized products during the large scale reactions and their ready dehydrogenation with 1 equiv of base support this proposed two-step path.
authors.affiliation: Division of Organic Chemistry, CSIR-National Chemical Laboratory , Dr. Homi Bhabha Road, Pune-411008, India.
authors.forename: B Narendraprasad
authors.initials: BN
authors.lastname: Reddy
authors.affiliation: Division of Organic Chemistry, CSIR-National Chemical Laboratory , Dr. Homi Bhabha Road, Pune-411008, India.
authors.forename: Chepuri V
authors.identifier: 0000-0001-5801-311X
authors.initials: CV
authors.lastname: Ramana