title: Proteotypic Peptides and Their Applications.
abstract: Recent advances in mass spectrometry based proteomic techniques and publicly available large proteomic repositories are being exploited to characterize the proteome of multiple organisms. While humongous amount of proteomic data is being acquired and analyzed, many biological questions still remain unanswered. Proteotypic peptides which uniquely represent target proteins or a protein isoform are used as an alternative strategy for protein identification in the field of immunological methods and targeted proteomic techniques. Using different computational approaches, resources and techniques used in the identification of proteotypic peptides of target proteins is discussed here.
authors.affiliation: Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, 3086, Australia. S.Keerthikumar@latrobe.edu.au.
authors.forename: Shivakumar
authors.initials: S
authors.lastname: Keerthikumar
authors.affiliation: Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, 3086, Australia.
authors.forename: Suresh
authors.initials: S
authors.lastname: Mathivanan
mesh_terms: D015415:Biomarkers; D019295:Computational Biology / Q000379:methods*; D030562:Databases, Protein; D010455:Peptides; D020543:Proteome; D040901:Proteomics / Q000379:methods*; D012984:Software; D064878:Web Browser
chemical_list: D015415:Biomarkers; D010455:Peptides; D020543:Proteome
keywords: Bioinformatics; Biomarkers; Databases; Selected reaction monitoring; Targeted proteomics