title: Antioxidant activities of the polysaccharides of Chuanminshen violaceum.
abstract: The water-soluble polysaccharides were extracted and purified from the root of Chuanminshen violaceum (CVPS). The antioxidant activities of the CVPS were evaluated both with in vitro and in vivo experiments. The results of the in vitro antioxidant assay suggested that the CVPS scavenged DPPH, hydroxyl, and superoxide anion radicals. The oral administration of three different doses of CVPS administered over a period of 6 weeks to D-galactose induced aging mice models, enhanced the activities of T-SOD, Mn-SOD, Cu, Zn-SOD, and CAT, and markedly decreased the content of MDA. Therefore, significant up-regulation of mRNA expression levels of Cu, Zn-SOD, Mn-SOD, CAT, glutathione peroxidase 1 (GPx), thioredoxin 1 (Trx1), and thioredoxin 2 (Trx1) occurred. Finally, the results demonstrated that the CVPS are a novel potential resource for natural antioxidants and anti-aging drugs.
authors.affiliation: Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu, Sichuan, 610051, PR China.
authors.forename: Jing
authors.initials: J
authors.lastname: Fan
authors.affiliation: Department of Veterinary Medicine, Southwest University, Rongchang, Chongqing 402460, PR China. Electronic address: fenghaiborc@126.com.
authors.forename: Haibo
authors.initials: H
authors.lastname: Feng
authors.affiliation: Department of Veterinary Medicine, Southwest University, Rongchang, Chongqing 402460, PR China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Yu
authors.affiliation: Department of Veterinary Medicine, Southwest University, Rongchang, Chongqing 402460, PR China.
authors.forename: Mingxian
authors.initials: M
authors.lastname: Sun
authors.affiliation: Department of Veterinary Medicine, Southwest University, Rongchang, Chongqing 402460, PR China.
authors.forename: Yuren
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Veterinary Medicine, Southwest University, Rongchang, Chongqing 402460, PR China.
authors.forename: Tongzhan
authors.initials: T
authors.lastname: Li
authors.affiliation: Department of Veterinary Medicine, Southwest University, Rongchang, Chongqing 402460, PR China.
authors.forename: Xin
authors.initials: X
authors.lastname: Sun
authors.affiliation: Department of Veterinary Medicine, Southwest University, Rongchang, Chongqing 402460, PR China.
authors.forename: Shuaijie
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of Veterinary Medicine, Southwest University, Rongchang, Chongqing 402460, PR China.
authors.forename: Mengdi
authors.initials: M
authors.lastname: Sun
mesh_terms: D000375:Aging / Q000187:drug effects*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D019661:Apiaceae / Q000737:chemistry*; D002374:Catalase / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010084:Oxidation-Reduction; D011134:Polysaccharides / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000378:metabolism; D013879:Thioredoxins / Q000378:metabolism
chemical_list: D000975:Antioxidants; D011134:Polysaccharides; D013879:Thioredoxins; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase
keywords: Anti-aging; Antioxidant activity; Chuanmingshen violacenm polysaccharides