title: Distinct Interactions between Fronto-Parietal and Default Mode Networks in Impaired Consciousness.
abstract: Existing evidence suggests that the default-mode network (DMN) and fronto-pariatal network (FPN) play an important role in altered states of consciousness. However, the brain mechanisms underlying impaired consciousness and the specific network interactions involved are not well understood. We studied the topological properties of brain functional networks using resting-state functional MRI data acquired from 18 patients (11 vegetative state/unresponsive wakefulness syndrome, VS/UWS, and 7 minimally conscious state, MCS) and compared these properties with those of healthy controls. We identified that the topological properties in DMN and FPN are anti-correlated which comes, in part, from the contribution of interactions between dorsolateral prefrontal cortex of the FPN and precuneus of the DMN. Notably, altered nodal connectivity strength was distance-dependent, with most disruptions appearing in long-distance connections within the FPN but in short-distance connections within the DMN. A multivariate pattern-classification analysis revealed that combination of topological patterns between the FPN and DMN could predict conscious state more effectively than connectivity within either network. Taken together, our results imply distinct interactions between the FPN and DMN, which may mediate conscious state.
authors.affiliation: Collage of Information Science and Technology, Jinan University, Guangzhou 510632, China.|Center for Brain Computer Interfaces and Brain Information Processing, South China University of Technology, Guangzhou 510640, China.
authors.forename: Jinyi
authors.initials: J
authors.lastname: Long
authors.affiliation: Coma Research Group, Centre for Hyperbaric Oxygen and Neurorehabilitation, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou 510010, China.
authors.forename: Qiuyou
authors.initials: Q
authors.lastname: Xie
authors.affiliation: Coma Research Group, Centre for Hyperbaric Oxygen and Neurorehabilitation, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou 510010, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Ma
authors.affiliation: Program in Physical Therapy, Washington University School of Medicine, St. Louis, MO 63108, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Urbin
authors.affiliation: Brain Imaging Center, Center for Studies of Psychological Application, School of Psychology, South China Normal University, Guangzhou 50016, China.
authors.forename: Liqing
authors.initials: L
authors.lastname: Liu
authors.affiliation: Brain Imaging Center, Center for Studies of Psychological Application, School of Psychology, South China Normal University, Guangzhou 50016, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Weng
authors.affiliation: Huaxi MR Research Center, Department of Radiology, West China Hospital of Sichuan University, Chengdu 610041, China.
authors.forename: Xiaoqi
authors.initials: X
authors.lastname: Huang
authors.affiliation: Coma Research Group, Centre for Hyperbaric Oxygen and Neurorehabilitation, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou 510010, China.
authors.forename: Ronghao
authors.initials: R
authors.lastname: Yu
authors.affiliation: Center for Brain Computer Interfaces and Brain Information Processing, South China University of Technology, Guangzhou 510640, China.
authors.forename: Yuanqing
authors.initials: Y
authors.lastname: Li
authors.affiliation: Brain Imaging Center, Center for Studies of Psychological Application, School of Psychology, South China Normal University, Guangzhou 50016, China.
authors.forename: Ruiwang
authors.initials: R
authors.lastname: Huang
mesh_terms: D000328:Adult; D001921:Brain / Q000503:physiopathology; D001931:Brain Mapping; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009434:Neural Pathways / Q000503:physiopathology; D010296:Parietal Lobe / Q000503:physiopathology*; D018458:Persistent Vegetative State / Q000503:physiopathology*