title: Use of anteromedial thigh perforator flap and immunological implications of Gorlin-Goltz syndrome: a case study.
abstract: Gorlin-Goltz syndrome is mainly characterised by the development of numerous multicentric and relapsing cutaneous basal cell carcinomas (BCCs). A major problem for patients with Gorlin-Goltz syndrome is the large amount of BCCs that can invade the deep underlying structures, especially the face. Here, we describe the case of a 23-year-old male affected by Gorlin-Goltz syndrome. He had recurrent BCCs on a hairless scalp and dorsum since he was 17 years old and underwent four surgical procedures to excise BCCs, including a reconstruction with anteromedial thigh perforator flap. For each of the surgical procedures, a phenotypic study on peripheral blood mononuclear cells using flow cytometry was performed on the same day of surgery, and on days 7, 14 and 21 after surgery. The role of the tumour-specific cytolytic immune response as a potential future treatment of syndromic BCCs and its trend in relation to surgical ablation of large portions of tumour tissue was examined, and the cosmetic and therapeutic results are shown.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Politechnical University of Marche, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Scalise
authors.affiliation: Department of Plastic and Reconstructive Surgery, Politechnical University of Marche, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Calamita
authors.affiliation: Department of Plastic and Reconstructive Surgery, Politechnical University of Marche, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Tartaglione
authors.affiliation: Department of Plastic and Reconstructive Surgery, Politechnical University of Marche, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Bolletta
authors.affiliation: Department of Plastic and Reconstructive Surgery, Politechnical University of Marche, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Di Benedetto
authors.affiliation: Department of Plastic and Reconstructive Surgery, Politechnical University of Marche, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Pierangeli
mesh_terms: D001478:Basal Cell Nevus Syndrome / Q000276:immunology* / Q000601:surgery*; D006258:Head and Neck Neoplasms / Q000276:immunology* / Q000601:surgery*; D006801:Humans; D008297:Male; D061525:Perforator Flap; D010641:Phenotype; D013848:Thigh; D055815:Young Adult
keywords: Gorlin-Goltz syndrome; basal cell nevus syndrome; carcinoma; free tissue flaps