title: Endothelial miRNAs as Cellular Messengers in Cardiometabolic Diseases.
abstract: Metabolic syndrome is a clustering of risk factors that increases susceptibility to serious cardiometabolic complications, including type 2 diabetes (T2D) and myocardial infarction. Understanding the underlying mechanisms will advance the development of diagnostic and therapeutic approaches. A prominent feature of cardiometabolic diseases is endothelial dysfunction. Endothelial cell (EC) homeostasis and response to pathological stimuli are controlled by gene regulatory networks in which miRNAs play a critical role. Recently, miRNAs have been implicated as cell-cell messengers that can influence cellular function. This review investigates the known and potential roles for miRNA-based cell-cell communication in the control of cardiovascular health and explores the value of identifying miRNA biomarkers and developing therapeutics that harness or antagonize miRNA-based communication.
authors.affiliation: Laboratory of Molecular Angiogenesis, GIGA-R, University of Liège, Liège, Belgium; Toronto General Hospital Research Institute, University Health Network, Toronto, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada; Heart and Stroke Richard Lewar Centre of Excellence in Cardiovascular Research, Toronto, Canada. Electronic address: sebastien.njock@gmail.com.
authors.forename: Makon-Sébastien
authors.initials: MS
authors.lastname: Njock
authors.affiliation: Toronto General Hospital Research Institute, University Health Network, Toronto, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada; Heart and Stroke Richard Lewar Centre of Excellence in Cardiovascular Research, Toronto, Canada. Electronic address: jason.fish@utoronto.ca.
authors.forename: Jason E
authors.initials: JE
authors.lastname: Fish
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000378:metabolism; D042783:Endothelial Cells / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D024821:Metabolic Syndrome / Q000235:genetics / Q000378:metabolism*; D035683:MicroRNAs / Q000378:metabolism*
chemical_list: D035683:MicroRNAs
keywords: cardiometabolic disease; endothelial cell; inflammation; metabolic syndrome; miRNA