title: Short-wavelength infrared laser activates the auditory neurons: comparing the effect of 980 vs. 810 nm wavelength.
abstract: Research on auditory neural triggering by optical stimulus has been developed as an emerging technique to elicit the auditory neural response, which may provide an alternative method to the cochlear implants. However, most previous studies have been focused on using longer-wavelength near-infrared (>1800 nm) laser. The effect comparison of different laser wavelengths in short-wavelength infrared (SWIR) range on the auditory neural stimulation has not been previously explored. In this study, the pulsed 980- and 810-nm SWIR lasers were applied as optical stimuli to irradiate the auditory neurons in the cochlea of five deafened guinea pigs and the neural response under the two laser wavelengths was compared by recording the evoked optical auditory brainstem responses (OABRs). In addition, the effect of radiant exposure, laser pulse width, and threshold with the two laser wavelengths was further investigated and compared. The one-way analysis of variance (ANOVA) was used to analyze those data. Results showed that the OABR amplitude with the 980-nm laser is higher than the amplitude with the 810-nm laser under the same radiant exposure from 10 to 102 mJ/cm2. And the laser stimulation of 980 nm wavelength has lower threshold radiant exposure than the 810 nm wavelength at varied pulse duration in 20-500 μs range. Moreover, the 810-nm laser has a wider optimized pulse duration range than the 980-nm laser for the auditory neural stimulation.
authors.affiliation: School of Microelectronics, Shandong University, Jinan, 250100, Shandong, China.
authors.forename: Lan
authors.initials: L
authors.lastname: Tian
authors.affiliation: Research Center of Laser Fusion, China Academy of Engineering Physics, Mianyang, 621900, Sichuan, China.
authors.forename: Jingxuan
authors.initials: J
authors.lastname: Wang
authors.affiliation: School of Information Science and Engineering, Shandong University, Jinan, 250100, Shandong, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wei
authors.affiliation: School of Information Science and Engineering, Shandong University, Jinan, 250100, Shandong, China.
authors.forename: Jianren
authors.initials: J
authors.lastname: Lu
authors.affiliation: Department of Otorhinolaryngology and Head and Neck Surgery, The Second Hospital of Shandong University, Jinan, 250100, Shandong, China.
authors.forename: Anting
authors.initials: A
authors.lastname: Xu
authors.affiliation: Department of Otorhinolaryngology and Head and Neck Surgery, The Second Hospital of Shandong University, Jinan, 250100, Shandong, China. xiamingsdu@sohu.com.
authors.forename: Ming
authors.initials: M
authors.lastname: Xia
mesh_terms: D000818:Animals; D001309:Auditory Threshold; D003051:Cochlea / Q000502:physiology / Q000528:radiation effects; D003056:Cochlear Nerve / Q000502:physiology / Q000528:radiation effects*; D016057:Evoked Potentials, Auditory, Brain Stem / Q000528:radiation effects; D006168:Guinea Pigs; D007834:Lasers; D008027:Light; D008297:Male; D009474:Neurons / Q000528:radiation effects*
keywords: Auditory brainstem response; Auditory neuron; Cochlea; Laser stimulation; Short-wavelength infrared