title: Brown fat thermogenesis: Stability of developmental programming and transient effects of temperature and gut microbiota in adults.
abstract: Evidence from animal studies continues to document the effectiveness of brown fat based thermogenesis in stimulating energy expenditure to reduce obesity. Evidence shows that the number of brown adipocytes in white fat is determined by developmental mechanisms, not the environment. The large variability in the capacity for brown fat thermogenesis comes from genetic variability in developmental mechanisms extent in the animal. This genetic variability ultimately drives the capacity for induction of the brown adipocyte phenotype in response to environmental signals in adult animals. We highlight recent studies that suggest a role for gut microbiota in the regulation of brown fat thermogenesis that is based, in part, upon the observation that bile acids can effectively induce thermogenesis by interscapular brown fat at thermoneutrality.
authors.affiliation: Department of Prophylaxis of Metabolic Diseases, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland.
authors.forename: Marika
authors.initials: M
authors.lastname: Ziętak
authors.affiliation: Institute of Pharmacology and Toxicology, University Hospital Bonn, University of Bonn, Bonn, Germany.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Chabowska-Kita
authors.affiliation: Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland. Electronic address: kozakleaf@gmail.com.
authors.forename: Leslie Paul
authors.initials: LP
authors.lastname: Kozak
mesh_terms: D052437:Adipocytes, Brown / Q000187:drug effects / Q000378:metabolism* / Q000382:microbiology / Q000473:pathology; D052438:Adipocytes, White / Q000187:drug effects / Q000378:metabolism* / Q000382:microbiology / Q000473:pathology; D000328:Adult; D000818:Animals; D001647:Bile Acids and Salts / Q000494:pharmacology; D002452:Cell Count; D004734:Energy Metabolism; D000069196:Gastrointestinal Microbiome / Q000502:physiology*; D005786:Gene Expression Regulation; D006801:Humans; D051379:Mice; D009765:Obesity / Q000235:genetics* / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D011941:Receptors, Adrenergic / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D013696:Temperature; D022722:Thermogenesis / Q000235:genetics*; D000071256:Uncoupling Protein 1 / Q000235:genetics* / Q000378:metabolism
chemical_list: D001647:Bile Acids and Salts; D011941:Receptors, Adrenergic; C000604371:UCP1 protein, human; D000071256:Uncoupling Protein 1
keywords: Bile acids; Brown adipocytes; Genetic variability; Gut microbiota; Inguinal white fat; Interscapular brown fat; Postnatal development; Reduced ambient temperature; Thermoneutrality