title: Subtypes evaluation of motor dysfunction in Parkinson's disease using neuromelanin-sensitive magnetic resonance imaging.
abstract: Parkinson's disease (PD) is characterized by the loss of neuromelanin (NM)-containing neurons in the substantia nigra pars compacta (SNc), and it is divided into two motor subtypes: the postural instability gait difficulty (PIGD) and the tremor dominant (TD) subtypes. With NM-sensitive Magnetic Resonance Imaging (NM-MRI), investigators have been able to accurately detect signal attenuation in SNc of PD; however, the difference of NM loss between PIGD and TD subtypes is still unclear. Thus, the aim of this study was to evaluate the differences in NM-MRI between PD motor subtypes. PD patients were classified into PIGD (n=14) and TD groups (n=9); 20 age and sex matched controls were recruited. We compared the signal intensity contrast ratios in medial and lateral regions of the SNc using NM-MRI in PIGD, TD, and controls, respectively. Remarkable signal attenuation was observed in the lateral part of SNc in PD when compared with the controls, and we were able to detect more severe signal attenuation in the medial part of SNc in PIGD patients in comparison with that in the TD group. Also, the medial part of SNc, ipsilateral to the most clinically affected side, showed the highest power to discriminate the PD motor subtypes (AUC, 81%; sensitivity, 71.4%; specificity, 77.8%). Our results indicated a potential diagnostic value of NM-MRI to discriminate the PD motor subtypes, providing new evidence for the neuropathology-based differences between the two subtypes.
authors.affiliation: Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, PR China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Xiang
authors.affiliation: Shandong Medical Imaging Research Institute Affiliated to Shandong University, Jinan, Shandong, PR China.
authors.forename: Tao
authors.initials: T
authors.lastname: Gong
authors.affiliation: Department of Orthopaedics, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, PR China.
authors.forename: Junwei
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, PR China.
authors.forename: Jifeng
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, PR China.
authors.forename: Yongxiang
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, PR China.
authors.forename: Shan
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, PR China.
authors.forename: Lin
authors.initials: L
authors.lastname: Cong
authors.affiliation: Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, PR China.
authors.forename: Youting
authors.initials: Y
authors.lastname: Lin
authors.affiliation: Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, PR China.
authors.forename: Yuxiang
authors.initials: Y
authors.lastname: Han
authors.affiliation: Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, PR China.
authors.forename: Ling
authors.initials: L
authors.lastname: Yin
authors.affiliation: Shandong Medical Imaging Research Institute Affiliated to Shandong University, Jinan, Shandong, PR China. Electronic address: wgb7932596@hotmail.com.
authors.forename: Guangbin
authors.initials: G
authors.lastname: Wang
authors.affiliation: Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, PR China. Electronic address: 13173015523@163.com.
authors.forename: Yifeng
authors.initials: Y
authors.lastname: Du
mesh_terms: D000368:Aged; D001931:Brain Mapping; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008543:Melanins / Q000378:metabolism*; D008875:Middle Aged; D010300:Parkinson Disease / Q000000981:diagnostic imaging / Q000503:physiopathology*; D065842:Pars Compacta / Q000000981:diagnostic imaging / Q000378:metabolism*; D011446:Prospective Studies
chemical_list: D008543:Melanins; C014121:neuromelanin
keywords: Magnetic resonance imaging; Motor subtypes; Neuromelanin; Parkinson’s disease; Substantia nigra