title: From the molecule to the mole: improving heterogeneous copper catalyzed click chemistry using single molecule spectroscopy.
abstract: Single molecule spectroscopy (SMS) inspired the optimization of a heterogeneous 'click' catalyst leading to enhanced yields of the Cu-catalyzed reaction of azides with terminal alkynes. Changes in SMS data after optimization confirm the improvements in catalyst performance.
authors.affiliation: Department of Chemistry and Biomolecular Sciences and Centre for Catalysis Research and Innovation (CCRI), University of Ottawa, 10 Marie Curie, Ottawa, ON K1N 6N5, Canada. anabel.lanterna@icloud.com titoscaiano@mac.com and State Key Laboratory of Chemical Resource Engineering, Faculty of Science, Beijing University of Chemical Technology, Beijing 100029, China.
authors.forename: Bowen
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Chemistry and Biomolecular Sciences and Centre for Catalysis Research and Innovation (CCRI), University of Ottawa, 10 Marie Curie, Ottawa, ON K1N 6N5, Canada. anabel.lanterna@icloud.com titoscaiano@mac.com.
authors.forename: Javier
authors.initials: J
authors.lastname: Durantini
authors.affiliation: Department of Chemistry and Biomolecular Sciences and Centre for Catalysis Research and Innovation (CCRI), University of Ottawa, 10 Marie Curie, Ottawa, ON K1N 6N5, Canada. anabel.lanterna@icloud.com titoscaiano@mac.com.
authors.forename: Matthew R
authors.identifier: http://orcid.org/0000-0002-8705-9835
authors.initials: MR
authors.lastname: Decan
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Faculty of Science, Beijing University of Chemical Technology, Beijing 100029, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Nie
authors.affiliation: Department of Chemistry and Biomolecular Sciences and Centre for Catalysis Research and Innovation (CCRI), University of Ottawa, 10 Marie Curie, Ottawa, ON K1N 6N5, Canada. anabel.lanterna@icloud.com titoscaiano@mac.com.
authors.forename: Anabel E
authors.identifier: http://orcid.org/0000-0002-6743-0940
authors.initials: AE
authors.lastname: Lanterna
authors.affiliation: Department of Chemistry and Biomolecular Sciences and Centre for Catalysis Research and Innovation (CCRI), University of Ottawa, 10 Marie Curie, Ottawa, ON K1N 6N5, Canada. anabel.lanterna@icloud.com titoscaiano@mac.com.
authors.forename: Juan C
authors.identifier: http://orcid.org/0000-0002-4838-7123
authors.initials: JC
authors.lastname: Scaiano
mesh_terms: D000480:Alkynes / Q000737:chemistry; D001386:Azides / Q000737:chemistry; D002384:Catalysis; D057930:Click Chemistry; D003300:Copper / Q000737:chemistry*; D013057:Spectrum Analysis
chemical_list: D000480:Alkynes; D001386:Azides; D003300:Copper