title: Acute Bilateral Renal and Splenic Infarctions Occurring during Chemotherapy for Lung Cancer.
abstract: We herein report a rare case of acute bilateral renal and splenic infarctions occurring during chemotherapy for lung cancer. A 60-year-old man presented with acute and intensive upper abdominal and back pain during chemotherapy with cisplatin and etoposide for lung cancer. Contrast-enhanced computed tomography (CT) revealed bilateral renal and splenic infarctions. After the administration of unfractionated heparin his pain was relieved with a clearance of the infarctions in the CT findings and a recovery of renal dysfunction. Enhanced coagulation by lung cancer and arterial ischemia by chemotherapy may therefore contribute to the development of these infarctions.
authors.affiliation: The Second Department of Internal Medicine, Nara Medical University, Japan.
authors.forename: Noriko
authors.initials: N
authors.lastname: Koyama
authors.forename: Koichi
authors.initials: K
authors.lastname: Tomoda
authors.forename: Masayuki
authors.initials: M
authors.lastname: Matsuda
authors.forename: Yukio
authors.initials: Y
authors.lastname: Fujita
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Shigeto
authors.initials: S
authors.lastname: Hontsu
authors.forename: Masato
authors.initials: M
authors.lastname: Tasaki
authors.forename: Masanori
authors.initials: M
authors.lastname: Yoshikawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kimura
mesh_terms: D015746:Abdominal Pain / Q000209:etiology; D000925:Anticoagulants / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001416:Back Pain / Q000209:etiology; D002945:Cisplatin / Q000009:adverse effects / Q000627:therapeutic use; D005047:Etoposide / Q000009:adverse effects / Q000627:therapeutic use; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D007238:Infarction / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology; D007668:Kidney / Q000098:blood supply; D007674:Kidney Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology; D008175:Lung Neoplasms / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D013154:Spleen / Q000098:blood supply; D013158:Splenic Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants; D000970:Antineoplastic Agents; D005047:Etoposide; D006493:Heparin; D002945:Cisplatin