title: Evaluating the Correlation Between the Survival Rate of Patients with Esophageal Squamous Cell Carcinoma and Expression of p53 and Cyclin D1 Biomarkers Along with Other Prognostic Factors.
abstract: OBJECTIVE
  In the present study, we aimed to evaluate the relationship between the survival rate of patients with esophageal squamous cell carcinoma (SCC) and expression of two biomarkers along with age, gender, tumor margin, depth of invasion, site of tumor, tumor diameter, tumor grade, number of involved nodes, and vascular invasion.
  
  
  METHODS
  In this retrospective survey, medical records of patients referred to the Shohada-e Tajrish hospital during 2001 to 2005 were reviewed and subjects with definite diagnosis of SCC were included. Required data were extracted from the patients' records, and their prepared paraffin-embedded tissue blocks were collected under supervision of two pathologists. Immunohistochemistry (IHC) analysis was performed at the Firoozgar hospital in Tehran, Iran.
  
  
  RESULTS
  The studied population included 20 men (74%) and 7 women (26%). The mean age at diagnosis was 58 ± 22. Results showed significantly higher survival rates in women compared to men (85.7 vs. 40%) (p = 0.001) and in patients with well-differentiated tumors compared to poor-differentiated cases (20 vs. 5%) (p = 0.004). No significant relationship was found between p53 expression and prognostic factors like age, gender, the site, grade, and size of the tumor, depth of invasion, involvement of lymph nodes, and vascular invasion.
  
  
  CONCLUSIONS
  Positivity of p53 and cyclin D1 was not found to be predictive of survival in patients with esophageal SCC which might be due to the small sample size of the present survey. Further investigations with larger sample populations and longer follow-ups are required to evaluate this correlation.
authors.affiliation: Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences, Tehran, Iran.|Medical Biotechnology Department, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Nazanin
authors.initials: N
authors.lastname: Saemi
authors.affiliation: Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Jalaleddin
authors.initials: J
authors.lastname: Khoshnevis
authors.affiliation: Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Mohammad Esmaeil
authors.initials: ME
authors.lastname: Akbari
authors.affiliation: Community Medicine Department, Medical Faculty, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Alipasha
authors.initials: A
authors.lastname: Meysamie
authors.affiliation: Cellular and Molecular Research Center, Faculty of Allied Sciences, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Korourian
authors.affiliation: Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Barmak
authors.initials: B
authors.lastname: Gholizadeh
authors.affiliation: Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Leila
authors.initials: L
authors.lastname: Larijani
authors.affiliation: Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Afshin
authors.initials: A
authors.lastname: Moradi
authors.affiliation: Department of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Masoud
authors.initials: M
authors.lastname: Baikpour
authors.affiliation: Medical Biotechnology Department, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Baikpour
authors.affiliation: Medical Biotechnology Department, Iran University of Medical Sciences, Tehran, Iran. h_zham@yahoo.com.|Cancer Research Center (CRC), Tajrish Shohada Hospital, Dr. Sharieati street, Ghods square, Tehran, Iran. h_zham@yahoo.com.
authors.forename: Hanieh
authors.initials: H
authors.lastname: Zham
mesh_terms: D014408:Biomarkers, Tumor / Q000096:biosynthesis* / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D019938:Cyclin D1 / Q000096:biosynthesis* / Q000235:genetics; D004938:Esophageal Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D000077277:Esophageal Squamous Cell Carcinoma; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D015996:Survival Rate; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; C530104:CCND1 protein, human; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; D019938:Cyclin D1
keywords: Cyclin D1; Esophageal squamous cell carcinoma; Immunohistochemistry; p53