title: Management of necrotizing scleritis after pterygium surgery with rituximab.
abstract: The authors present a case of necrotizing scleritis after pterygium excision successfully treated with rituximab after attempts with high doses of corticosteroids and immunosuppressive drugs. A literature review revealed case reports and a phase I/II dose-ranging randomized clinical trial using rituximab for necrotizing scleritis with or without association with autoimmune disease. This is the only case report on rituximab treatment for necrotizing scleritis after pterygium surgery. In cases with refractoriness to immunosuppressive drugs, a CD20 antibody can be used.
authors.affiliation: Departamento de Oftalmologia e Ciências Visuais, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.
authors.forename: Tania Sales de Alencar
authors.initials: TS
authors.lastname: Fidelix
authors.affiliation: Departamento de Oftalmologia e Ciências Visuais, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.
authors.forename: Luis Antonio
authors.initials: LA
authors.lastname: Vieira
authors.affiliation: Departamento de Oftalmologia e Ciências Visuais, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.
authors.forename: Virginia Fernandes Moca
authors.initials: VF
authors.lastname: Trevisani
mesh_terms: D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D008875:Middle Aged; D013508:Ophthalmologic Surgical Procedures / Q000009:adverse effects; D011183:Postoperative Complications / Q000188:drug therapy / Q000209:etiology; D011625:Pterygium / Q000601:surgery*; D015203:Reproducibility of Results; D000069283:Rituximab / Q000627:therapeutic use*; D012590:Sclera / Q000187:drug effects / Q000473:pathology; D015423:Scleritis / Q000188:drug therapy* / Q000209:etiology; D016896:Treatment Outcome
chemical_list: D007155:Immunologic Factors; D000069283:Rituximab