title: Screening Breast MRI Outcomes in Routine Clinical Practice: Comparison to BI-RADS Benchmarks.
abstract: The BI-RADS Atlas 5th Edition includes screening breast magnetic resonance imaging (MRI) outcome benchmarks. However, the metrics are from expert practices and clinical trials of women with hereditary breast cancer predispositions, and it is unknown if they are appropriate for routine practice. We evaluated screening breast MRI audit outcomes in routine practice across a spectrum of elevated risk patients.
  
  
  
  This Institutional Review Board-approved, Health Insurance Portability and Accountability Act-compliant retrospective study included all consecutive screening breast MRI examinations from July 1, 2010 to June 30, 2013. Examination indications were categorized as gene mutation carrier (GMC), personal history (PH) breast cancer, family history (FH) breast cancer, chest radiation, and atypia/lobular carcinoma in situ (LCIS). Outcomes were determined by pathology and/or ≥12 months clinical and/or imaging follow-up. We calculated abnormal interpretation rate (AIR), cancer detection rate (CDR), positive predictive value of recommendation for tissue diagnosis (PPV2) and biopsy performed (PPV3), and median size and percentage of node-negative invasive cancers.
  
  
  
  Eight hundred and sixty examinations were performed in 566 patients with a mean age of 47 years. Indications were 367 of 860 (42.7%) FH, 365 of 860 (42.4%) PH, 106 of 860 (12.3%) GMC, 14 of 860 (1.6%) chest radiation, and 8 of 22 (0.9%) atypia/LCIS. The AIR was 134 of 860 (15.6%). Nineteen cancers were identified (13 invasive, 4 DCIS, two lymph nodes), resulting in CDR of 19 of 860 (22.1 per 1000), PPV2 of 19 of 88 (21.6%), and PPV3 of 19 of 80 (23.8%). Of 13 invasive breast cancers, median size was 10 mm, and 8 of 13 were node negative (61.5%).
  
  
  
  Performance outcomes of screening breast MRI in routine clinical practice across a spectrum of elevated risk patients met the American College of Radiology Breast Imaging Reporting and Data System benchmarks, supporting broad application of these metrics. The indication of a personal history of treated breast cancer accounted for a large proportion (42%) of our screening examinations, with breast MRI performance in this population at least comparable to that of other screening indications.
authors.affiliation: Department of Radiology, University of Wisconsin, 600 Highland Ave, Madison, WI 53792; Department of Medical Physics, University of Wisconsin, Madison, Wisconsin; Carbone Cancer Center, University of Wisconsin, Madison, Wisconsin. Electronic address: rstrigel@uwhealth.org.
authors.forename: Roberta M
authors.initials: RM
authors.lastname: Strigel
authors.affiliation: Department of Radiology, University of Wisconsin, 600 Highland Ave, Madison, WI 53792.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Rollenhagen
authors.affiliation: Department of Radiology, University of Wisconsin, 600 Highland Ave, Madison, WI 53792; Carbone Cancer Center, University of Wisconsin, Madison, Wisconsin.
authors.forename: Elizabeth S
authors.initials: ES
authors.lastname: Burnside
authors.affiliation: Department of Radiology, University of Wisconsin, 600 Highland Ave, Madison, WI 53792.
authors.forename: Mai
authors.initials: M
authors.lastname: Elezaby
authors.affiliation: Department of Radiology, University of Wisconsin, 600 Highland Ave, Madison, WI 53792; Department of Medical Physics, University of Wisconsin, Madison, Wisconsin; Carbone Cancer Center, University of Wisconsin, Madison, Wisconsin.
authors.forename: Amy M
authors.initials: AM
authors.lastname: Fowler
authors.affiliation: Department of Radiology, University of Wisconsin, 600 Highland Ave, Madison, WI 53792.
authors.forename: Frederick
authors.initials: F
authors.lastname: Kelcz
authors.affiliation: Department of Radiology, University of Wisconsin, 600 Highland Ave, Madison, WI 53792.
authors.forename: Lonie
authors.initials: L
authors.lastname: Salkowski
authors.affiliation: Department of Radiology, University of Wisconsin, 600 Highland Ave, Madison, WI 53792.
authors.forename: Wendy B
authors.initials: WB
authors.lastname: DeMartini
mesh_terms: D000328:Adult; D000368:Aged; D019985:Benchmarking / Q000379:methods*; D001706:Biopsy / Q000379:methods; D001940:Breast / Q000000981:diagnostic imaging / Q000473:pathology; D000071960:Breast Carcinoma In Situ / Q000175:diagnosis / Q000473:pathology; D001943:Breast Neoplasms / Q000175:diagnosis / Q000473:pathology; D018275:Carcinoma, Lobular / Q000175:diagnosis / Q000473:pathology; D055088:Early Detection of Cancer / Q000379:methods / Q000592:standards; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods / Q000592:standards; D008485:Medical Audit / Q000706:statistics & numerical data; D008875:Middle Aged; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D014922:Wisconsin
keywords: Screening breast MRI; benchmarks; outcomes