title: Aspergillusmarch: from ABPA to aspergilloma to subacute invasive aspergillosis.
abstract: BACKGROUND
  Aspergillusis a ubiquitous fungus responsible for allergic as well as saprophytic and invasive manifestations depending on host's immune status. The following case report demonstrates progression of allergic manifestations ofAspergillusto its invasive form in an individual with decreasing immunity. This can lead to uncertainties in diagnosis and management.
  
  
  METHODS
  A 28-year-old male, non smoker, known case of ABPA (allergic bronchopulmonary aspergillosis) was admitted with complaints of cough for 1 month, associated with recurrent episodes of hemoptysis for last 5 days. CT Thorax revealed homogenous dense round opacity in right upper lobe which replaced previous fibrocalcific bronchiectatic lesion with cavity and aspergilloma, bulging across the major fissure with fibrotic strands extending to periphery in all directions. Post-pneumonectomy microscopic examination revealedAspergillushyphae invading blood vessels.
  
  
  CONCLUSIONS
  There is a need for close clinical and radiologic follow up of patients withAspergillusand our patient demonstrated overlap of complete spectrum ofAspergillusdisease with march from one end to the other end.
authors.affiliation: Rajiv Gandhi Superspeciality Hospital, Tahirpur, Delhi, 110093 India ; Metro Center for Respiratory Diseases, Metro Multispeciality Hospital, Sector 11, Noida, Uttar Pradesh India.
authors.forename: Vikas
authors.initials: V
authors.lastname: Dogra
authors.affiliation: Metro Center for Respiratory Diseases, Metro Multispeciality Hospital, Sector 11, Noida, Uttar Pradesh India.
authors.forename: Ankit Kumar
authors.initials: AK
authors.lastname: Sinha
authors.affiliation: Metro Center for Respiratory Diseases, Metro Multispeciality Hospital, Sector 11, Noida, Uttar Pradesh India.
authors.forename: Rajat
authors.initials: R
authors.lastname: Saxena
authors.affiliation: Metro Center for Respiratory Diseases, Metro Multispeciality Hospital, Sector 11, Noida, Uttar Pradesh India.
authors.forename: Deepak
authors.initials: D
authors.lastname: Talwar
keywords: Aspergilloma; Aspergillus; Asthma