title: Unusual Uptake of Prostate Specific Tracer68Ga-PSMA-HBED-CC in a Benign Thyroid Nodule.
abstract: 68Ga-Prostate specific membrane antigen-N,N'-bis[2-hydroxy-5-(carboxyethyl)benzyl]ethylenediamine-N,N'-diacetic acid- positron emission tomography/computed tomography or 68 Ga- HBED-CC-PSMA PET/CT, popularly known as PSMA PET/CT, is able to detect a small volume of recurrent prostate carcinoma (PC) when there is a prostate specific antigen (PSA) rise on follow-up after prostatectomy or other definitive treatment for PC. The use of PSMA PET/CT in the initial staging in PC is uncertain at this time. Clinical studies are underway to define its exact role in the management of the disease. At the same time it is important to be aware of unexpected sites of uptake of this ligand. We present here the case of a 62-year-old male patient who underwent prostatectomy for adenocarcinoma prostate. He also had a long-standing left solitary thyroid nodule (STN). Four months after surgery, he had a rising trend in serum PSA levels on three occasions, but the absolute value was less than 4 at all times. He underwent a68Ga-PSMA-HBED-CC PET/CT, but it did not reveal any recurrent/metastatic site of disease. However, there was increased tracer uptake in the left STN. Fine needle aspiration cytology revealed features of atypia of undetermined significance, Bethesda category III. The patient underwent a left hemithyroidectomy and the histopathology showed features of a follicular adenoma.
authors.affiliation: Department of Nuclear Medicine, A.I.I.M.S, New Delhi, India.
authors.forename: Nishikant Avinash
authors.initials: NA
authors.lastname: Damle
authors.affiliation: Department of Nuclear Medicine, A.I.I.M.S, New Delhi, India.
authors.forename: Madhavi
authors.initials: M
authors.lastname: Tripathi
authors.affiliation: Department of Nuclear Medicine, A.I.I.M.S, New Delhi, India.
authors.forename: Partha Sarathi
authors.initials: PS
authors.lastname: Chakraborty
authors.affiliation: Department of Nuclear Medicine, A.I.I.M.S, New Delhi, India.
authors.forename: Manas Kumar
authors.initials: MK
authors.lastname: Sahoo
authors.affiliation: Department of Nuclear Medicine, A.I.I.M.S, New Delhi, India.
authors.forename: Chandrasekhar
authors.initials: C
authors.lastname: Bal
authors.affiliation: Department of Pathology, A.I.I.M.S, New Delhi, India.
authors.forename: Shipra
authors.initials: S
authors.lastname: Aggarwal
authors.affiliation: Department of Nuclear Medicine, A.I.I.M.S, New Delhi, India.
authors.forename: Geetanjali
authors.initials: G
authors.lastname: Arora
authors.affiliation: Department of Nuclear Medicine, A.I.I.M.S, New Delhi, India.
authors.forename: Praveen
authors.initials: P
authors.lastname: Kumar
authors.affiliation: Department of Nuclear Medicine, A.I.I.M.S, New Delhi, India.
authors.forename: Rajeev
authors.initials: R
authors.lastname: Kumar
authors.affiliation: Department of Nuclear Medicine, A.I.I.M.S, New Delhi, India.
authors.forename: Ravikant
authors.initials: R
authors.lastname: Gupta
keywords: 68Gallium; PET/CT; PSMA; Prostate carcinoma