title: Transarterial Yttrium-90 Radioembolization Treatment of Patients with Liver-Dominant Metastatic Renal Cell Carcinoma.
abstract: OBJECTIVE
  To evaluate safety and efficacy of transarterial hepatic radioembolization treatment of patients with liver-dominant metastatic renal cell carcinoma (RCC).
  
  
  METHODS
  From July 2010 to December 2014, 18 patients with liver-dominant metastatic RCC were treated with yttrium-90 glass microsphere radioembolization. Retrospective review of medical records and imaging studies was performed to evaluate toxicities, treatment response, and overall survival. The median follow-up period from radioembolization treatment was 17.8 months (range, 3-54.4 months).
  
  
  RESULTS
  Median overall survival from RCC diagnosis was 64 months (95% confidence interval [CI], 0-144.1 months), from diagnosis of liver metastasis was 29 months (95% CI, 7.2-50.8 months), and from radioembolization treatment was 22.8 months (95% CI, 13.2-32.3 months). After treatment, 10 patients reported grade 1 clinical toxicities, and 8 patients had grade 1 or 2 biochemical toxicities. The best radiographic responses of 17 patients who underwent contrast-enhanced cross-sectional imaging showed complete response in 16 patients and partial response in 1 patient evaluated by modified Response Evaluation Criteria in Solid Tumors (mRECIST) criteria. The last available imaging of these 17 patients demonstrated complete response in 14 patients, partial response in 1 patient, and progression of disease in 2 patients. Images of a patient who underwent noncontrast CT showed stable disease as best response and stable disease on the last available imaging evaluated by RECIST.
  
  
  CONCLUSIONS
  Radioembolization is safe and effective and led to improved hepatic disease control and overall survival in patients with liver-dominant metastatic RCC.
authors.affiliation: Diagnostic Imaging and Interventional Radiology, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612. Electronic address: bela.kis@moffitt.org.
authors.forename: Bela
authors.initials: B
authors.lastname: Kis
authors.affiliation: Diagnostic Imaging and Interventional Radiology, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612.
authors.forename: Jehan
authors.initials: J
authors.lastname: Shah
authors.affiliation: Diagnostic Imaging and Interventional Radiology, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612.
authors.forename: Junsung
authors.initials: J
authors.lastname: Choi
authors.affiliation: Diagnostic Imaging and Interventional Radiology, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612.
authors.forename: Ghassan
authors.initials: G
authors.lastname: El-Haddad
authors.affiliation: Diagnostic Imaging and Interventional Radiology, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Sweeney
authors.affiliation: Diagnostic Imaging and Interventional Radiology, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Biebel
authors.affiliation: Radiation Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612.
authors.forename: Eric
authors.initials: E
authors.lastname: Mellon
authors.affiliation: Radiation Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612.
authors.forename: Jessica M
authors.initials: JM
authors.lastname: Frakes
authors.affiliation: Radiation Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612.
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Hoffe
authors.affiliation: Genitourinary Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612.
authors.forename: Mayer N
authors.initials: MN
authors.lastname: Fishman
authors.affiliation: Radiation Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612; Radiation Oncology, Florida Hospital Orlando, Orlando, Florida.
authors.forename: Ravi
authors.initials: R
authors.lastname: Shridhar
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002292:Carcinoma, Renal Cell / Q000000981:diagnostic imaging / Q000401:mortality / Q000556:secondary* / Q000628:therapy*; D004621:Embolization, Therapeutic / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D007680:Kidney Neoplasms / Q000401:mortality / Q000473:pathology*; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000401:mortality / Q000556:secondary* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D019275:Radiopharmaceuticals / Q000008:administration & dosage* / Q000009:adverse effects; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D015021:Yttrium Radioisotopes / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D019275:Radiopharmaceuticals; D015021:Yttrium Radioisotopes