title: The RNA Epistructurome: Uncovering RNA Function by Studying Structure and Post-Transcriptional Modifications.
abstract: A large fraction of higher metazoan genomes transcribe RNA molecules whose functions extend far beyond carrying instructions for protein synthesis. Although RNA is apparently a simple molecule, the ways in which it performs many of its functions have remained highly elusive for decades. As learned from studying ribosomal and transfer RNAs, two of the key features influencing the function of RNA are its structure and post-transcriptional modifications. A deep understanding of RNA function therefore requires rapid and straightforward approaches to study the complex and intricate landscape of RNA structures and modifications. In this review we summarize and discuss the most recent methods and findings in the field of RNA biology, with an eye toward new frontiers and open questions.
authors.affiliation: Human Genetics Foundation (HuGeF), Via Nizza 52, 10126 Torino, Italy; Dipartimento di Scienze della Vita e Biologia dei Sistemi, Università di Torino, Via Accademia Albertina 13, Torino, Italy. Electronic address: danny.incarnato@hugef-torino.org.
authors.forename: Danny
authors.initials: D
authors.lastname: Incarnato
authors.affiliation: Human Genetics Foundation (HuGeF), Via Nizza 52, 10126 Torino, Italy; Dipartimento di Scienze della Vita e Biologia dei Sistemi, Università di Torino, Via Accademia Albertina 13, Torino, Italy. Electronic address: salvatore.oliviero@hugef-torino.org.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Oliviero
mesh_terms: D000818:Animals; D004926:Escherichia coli / Q000235:genetics; D057166:High-Throughput Screening Assays; D006801:Humans; D051379:Mice; D009690:Nucleic Acid Conformation; D012313:RNA / Q000737:chemistry* / Q000378:metabolism*; D059370:RNA Folding; D012323:RNA Processing, Post-Transcriptional; D015003:Yeasts / Q000235:genetics
chemical_list: D012313:RNA
keywords: RNA folding; RNA structure; epistructurome; high-throughput sequencing; post-transcriptional modifications