title: Increased oxidative stress is associated with insulin resistance and infertility in polycystic ovary syndrome.
abstract: The present study aims to investigate the role of oxidant-antioxidant status in young women with polycystic ovary syndrome (PCOS).
  
  
  
  Seventy-one women with PCOS and 53 healthy controls are compared in aspect of demographic characteristics, biochemical data, hormones, and oxidant-antioxidant status.
  
  
  
  The PCOS group had significantly lower zinc, higher malondialdehyde and gluthathione peroxidase and lower serum catalase levels than the control group (p = 0.016, p < 0.001, p = 0.043 and p = 0.025 respectively). The PCOS patients with IR had significantly higher malondialdehyde, lower catalase and serum zinc levels than the PCOS patients without IR (p = 0.015, p = 0.010, p = 0.001 respectively). The infertile PCOS patients had significantly higher malondialdehyde, lower catalase and serum zinc levels than the fertile PCOS patients (p = 0.022, p = 0.045,p = 0.001 respectively). There was a statistically significant and positive correlation between HOMA-IR and malondialdehyde values (r = 0.523, p = 0.001), between HOMA-IR and glutathione peroxidase values (r = 0.468, p = 0.001) and between HOMA-IR and zinc values (r = 0.601, p = 0.001). There was a statistically significant and negative correlation between HOMA-IR and catalase values (r = -0.493, p = 0.001).
  
  
  
  The patients with PCOS are under oxidative stress and this oxidative stress seems to be the highest in patients with IR and with infertility. Despite the prominent increase in the oxidative stress, there was a variation in the antioxidant response.
authors.affiliation: Sütçü Imam University, Turkey. dralevozer@gmail.com.
authors.forename: Alev
authors.initials: A
authors.lastname: Özer
authors.forename: Murat
authors.initials: M
authors.lastname: Bakacak
authors.forename: Hakan
authors.initials: H
authors.lastname: Kıran
authors.forename: Önder
authors.initials: Ö
authors.lastname: Ercan
authors.forename: Bülent
authors.initials: B
authors.lastname: Köstü
authors.forename: Mine
authors.initials: M
authors.lastname: Kanat-Pektaş
authors.forename: Metin
authors.initials: M
authors.lastname: Kılınç
authors.forename: Ferhat
authors.initials: F
authors.lastname: Aslan
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D016022:Case-Control Studies; D002374:Catalase / Q000097:blood; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D007247:Infertility, Female / Q000097:blood / Q000209:etiology*; D007333:Insulin Resistance; D008315:Malondialdehyde / Q000097:blood; D018384:Oxidative Stress; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications* / Q000175:diagnosis*; D014131:Trace Elements / Q000097:blood; D015032:Zinc / Q000097:blood
chemical_list: D015415:Biomarkers; D014131:Trace Elements; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D015032:Zinc
keywords: infertility; insulin resistance; oxidative stress; polycystic ovary syndrome