title: [Mechanism of action of the SIRT1-FoxO1-AdipoR2 signaling pathway in alcoholic fatty liver disease].
abstract: Long-term alcohol stimulation may inhibit the expression of silent information regulator 1 in hepatocytes, which increases the acetylation level of forkhead box transcription factor O1, reduces nuclear localization, and reduces the binding capacity of DNA sequence. This further downregulates the expression of downstream adiponectin receptor 2 and microsomal triglyceride transfer protein, causes lipid metabolism disorders and triglyceride deposition in hepatocytes by affecting adiponectin signal transduction and synthesis of very-low-density lipoprotein, and finally promotes the development of alcoholic fatty liver disease.
authors.affiliation: Department of Infectious Disease, the Third Hospital of Hebei Medical University, Shijiazhuang 050051, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Sun
authors.forename: J Y
authors.initials: JY
authors.lastname: Zhou
mesh_terms: D052242:Adiponectin; D000818:Animals; D002352:Carrier Proteins; D000431:Ethanol; D005235:Fatty Liver, Alcoholic; D000071161:Forkhead Box Protein O1; D051858:Forkhead Transcription Factors / Q000502:physiology*; D022781:Hepatocytes; D006801:Humans; D052439:Lipid Metabolism Disorders; D008099:Liver; D015398:Signal Transduction / Q000502:physiology*; D056564:Sirtuin 1 / Q000502:physiology; D014157:Transcription Factors; D014280:Triglycerides; D015854:Up-Regulation / Q000502:physiology
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D002352:Carrier Proteins; D000071161:Forkhead Box Protein O1; D051858:Forkhead Transcription Factors; C467200:Foxo1 protein, mouse; D014157:Transcription Factors; D014280:Triglycerides; C106092:microsomal triglyceride transfer protein; D000431:Ethanol; D056564:Sirtuin 1