title: Environmental water chemistry and possible correlation with Kaschin-Beck Disease (KBD) in northwestern Sichuan, China.
abstract: During the past several decades, etiological and geochemical studies tend to link the Kaschin-Beck Disease (KBD) to the deficiency of some specific trace elements (e.g., selenium and iodine) in the environment; however the link has been proven inconclusive. In this work, we have investigated the relationship between KBD and the environment in a broader scope by examining comprehensively the chemistry of the surface waters in northwestern Sichuan, China, in relation to the KBD prevalence. The surface waters in the study area were found to be near neutral to slightly alkaline (pH6.70 to 8.85 with a mean of 7.91) and mostly soft (total hardness 35.2 to 314.3mg/L, mean 118.8mg/L) with low salinity (total dissolved solids (TDS) 44.5mg/L to 376.6mg/L, mean 146.6mg/L). The waters were dominated by cations Ca2+and Mg2+and anion HCO3-; whereas the alkali metal ions K+and Na+and the anions Cl-and S042-were relatively scarce. Spatially, the hardness/salinity of the surface waters exhibited a characteristic of being lower towards the center of the study area where most severe KBD endemic has been observed. Even though it is not conclusive at this stage, a correlation between KBD prevalence and the salinity/hardness of the surface waters of an area has been demonstrated. As a postulate, the long-term consumption of such low salinity waters may lead to a deficiency of some essential elements such as Ca, Mg, Se and I in humans, which may be a factor in inducing KBD. However, other factors such as high altitude and cold climate, poor nutrition and sanitary conditions may play an important role in the disease endemic.
authors.affiliation: College of Earth Sciences, Chengdu University of Technology, 1 Erxianqiao 3rd Street E., Chengdu, Sichuan 610059, China; Sichuan Province Key Laboratory of Nuclear Techniques in Geosciences, Chengdu, China.
authors.forename: Zeming
authors.initials: Z
authors.lastname: Shi
authors.affiliation: College of Earth Sciences, Chengdu University of Technology, 1 Erxianqiao 3rd Street E., Chengdu, Sichuan 610059, China. Electronic address: Pujing.Pan@outlook.com.
authors.forename: Pujing
authors.initials: P
authors.lastname: Pan
authors.affiliation: College of Earth Sciences, Chengdu University of Technology, 1 Erxianqiao 3rd Street E., Chengdu, Sichuan 610059, China.
authors.forename: Yanwei
authors.initials: Y
authors.lastname: Feng
authors.affiliation: Sichuan Institute of Geological Survey, Chengdu 610081, China.
authors.forename: Zezhong
authors.initials: Z
authors.lastname: Kan
authors.affiliation: Sichuan Institute of Geological Survey, Chengdu 610081, China.
authors.forename: Zhonghui
authors.initials: Z
authors.lastname: Li
authors.affiliation: College of Earth Sciences, Chengdu University of Technology, 1 Erxianqiao 3rd Street E., Chengdu, Sichuan 610059, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Wei
mesh_terms: D002681:China / Q000453:epidemiology; D060766:Drinking Water / Q000737:chemistry*; D006801:Humans; D057767:Kashin-Beck Disease / Q000139:chemically induced / Q000453:epidemiology*; D015995:Prevalence
chemical_list: D060766:Drinking Water
keywords: Kaschin-Beck Disease (KBD); NW Sichuan; Water chemistry; Water hardness and salinity