title: Radio frequency-mediated local thermotherapy for destruction of pancreatic tumors using Ni-Au core-shell nanowires.
abstract: We present a novel method of radio frequency (RF)-mediated thermotherapy in tumors by remotely heating nickel (Ni)-gold (Au) core-shell nanowires (CSNWs). Ectopic pancreatic tumors were developed in nude mice to evaluate the thermotherapeutic effects on tumor progression. Tumor ablation was produced by RF-mediated thermotherapy via activation of the paramagnetic properties of the Ni-Au CSNWs. Histopathology demonstrated that heat generated by RF irradiation caused significant cellular death with pyknotic nuclei and nuclear fragmentation dispersed throughout the tumors. These preliminary results suggest that thermotherapy ablation induced via RF activation of nanowires provides a potential alternative therapy for cancer treatment.
authors.affiliation: Department of Chemical and Materials Engineering, University of Idaho, Moscow, ID 83844, USA.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Hopkins
authors.forename: Waqas Amin
authors.initials: WA
authors.lastname: Gill
authors.forename: Rosemarie
authors.initials: R
authors.lastname: Kringel
authors.forename: Guankui
authors.initials: G
authors.lastname: Wang
authors.forename: Jamie
authors.initials: J
authors.lastname: Hass
authors.forename: Suresh
authors.initials: S
authors.lastname: Acharya
authors.forename: Jungrae
authors.initials: J
authors.lastname: Park
authors.forename: In Tak
authors.initials: IT
authors.lastname: Jeon
authors.forename: Boo Hyun
authors.initials: BH
authors.lastname: An
authors.forename: Ji Sung
authors.initials: JS
authors.lastname: Lee
authors.forename: Jong Eun
authors.initials: JE
authors.lastname: Ryu
authors.forename: Rod
authors.initials: R
authors.lastname: Hill
authors.forename: David
authors.initials: D
authors.lastname: McIlroy
authors.forename: Young Keun
authors.initials: YK
authors.lastname: Kim
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Choi
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D018450:Disease Progression; D006046:Gold / Q000737:chemistry; D006801:Humans; D006979:Hyperthermia, Induced / Q000295:instrumentation / Q000379:methods*; D058185:Magnetite Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D008297:Male; D051379:Mice; D008819:Mice, Nude; D053770:Nanowires / Q000008:administration & dosage* / Q000737:chemistry; D009532:Nickel / Q000737:chemistry; D010190:Pancreatic Neoplasms / Q000473:pathology / Q000628:therapy*; D061208:Pulsed Radiofrequency Treatment / Q000295:instrumentation* / Q000379:methods*; D023041:Xenograft Model Antitumor Assays
chemical_list: D058185:Magnetite Nanoparticles; D006046:Gold; D009532:Nickel