title: Gold nanoparticles increases UV and thermal stability of human serum albumin.
abstract: Ultraviolet (UV) radiation, temperature, and time can degrade proteins. Here, the authors show that gold nanoparticles significantly protect human serum albumin from denaturation when exposed to "stressing" conditions such as UV irradiation and sustained exposure in suboptimal conditions. In particular, the authors show that gold nanoparticles significantly reduce the decrease in secondary structure induced by UV irradiation or extended exposure to ambient temperature.
authors.affiliation: European Commission, DG Joint Research Centre, Via E. Fermi 2749, I-21027 Ispra (VA), Italy and UMR 5246 CNRS-Université Lyon 1-ICBMS, Université Claude Bernard Lyon 1, 43 Boulevard du 11 novembre 1918, 69622 Villeurbanne Cedex, France.
authors.forename: Robin
authors.initials: R
authors.lastname: Capomaccio
authors.affiliation: European Commission, DG Joint Research Centre, Via E. Fermi 2749, I-21027 Ispra (VA), Italy.
authors.forename: Inês
authors.initials: I
authors.lastname: Osório
authors.affiliation: European Commission, DG Joint Research Centre, Via E. Fermi 2749, I-21027 Ispra (VA), Italy.
authors.forename: Isaac
authors.initials: I
authors.lastname: Ojea-Jiménez
authors.affiliation: European Commission, DG Joint Research Centre, Via E. Fermi 2749, I-21027 Ispra (VA), Italy.
authors.forename: Giacomo
authors.initials: G
authors.lastname: Ceccone
authors.affiliation: European Commission, DG Joint Research Centre, Via E. Fermi 2749, I-21027 Ispra (VA), Italy.
authors.forename: Pascal
authors.initials: P
authors.lastname: Colpo
authors.affiliation: European Commission, DG Joint Research Centre, Via E. Fermi 2749, I-21027 Ispra (VA), Italy.
authors.forename: Douglas
authors.initials: D
authors.lastname: Gilliland
authors.affiliation: Diamond Light Source, Chilton, Didcot OX11 0DE, United Kingdom.
authors.forename: Rohanah
authors.initials: R
authors.lastname: Hussain
authors.affiliation: Diamond Light Source, Chilton, Didcot OX11 0DE, United Kingdom.
authors.forename: Giuliano
authors.initials: G
authors.lastname: Siligardi
authors.affiliation: European Commission, DG Joint Research Centre, Via E. Fermi 2749, I-21027 Ispra (VA), Italy.
authors.forename: Francois
authors.initials: F
authors.lastname: Rossi
authors.affiliation: UMR 5246 CNRS-Université Lyon 1-ICBMS, Université Claude Bernard Lyon 1, 43 Boulevard du 11 novembre 1918, 69622 Villeurbanne Cedex, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Ricard-Blum
authors.affiliation: European Commission, DG Joint Research Centre, Via E. Fermi 2749, I-21027 Ispra (VA), Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Calzolai
mesh_terms: D002942:Circular Dichroism; D006046:Gold; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D011487:Protein Conformation / Q000528:radiation effects; D011489:Protein Denaturation / Q000528:radiation effects*; D055550:Protein Stability; D012709:Serum Albumin / Q000737:chemistry*; D000075462:Serum Albumin, Human; D013696:Temperature; D013997:Time Factors; D014466:Ultraviolet Rays
chemical_list: C422455:ALB protein, human; D012709:Serum Albumin; D006046:Gold; D000075462:Serum Albumin, Human