title: Topical interventions to prevent acute radiation dermatitis in head and neck cancer patients: a systematic review.
abstract: The purpose of the study is to evaluate the effects of pharmacological and non-pharmacological topical controls in the prevention of radiation dermatitis.
  
  
  
  Relevant clinical trials were identified through electronic searching databases CINAHL, CENTRAL, LILACS, PubMed, Scopus, and Web of Science. Handsearching and gray literature searches were also performed to find additional references. Primary outcomes of interest were the development of radiation dermatitis and the time of occurrence of radiation dermatitis.
  
  
  
  Thirteen randomized clinical trials were included in this review. The trials were published in Chinese, English, or French, from 1980 to 2015. Pharmacological interventions used in the trials were trolamine, aloe vera, allantoin, Lianbai liquid, sucralfate, Na-sucrose octasulfate, olive oil, hialuronic acid, and dexpanthenol. Non-pharmacological topical controls were usual care/institution routine, aqueous cream, mild soap, water thermal gel, placebo, and no intervention.
  
  
  
  There was no strong evidence that indicates differences between topical pharmacological interventions or non-pharmacological topical controls in the prevention of acute radiation dermatitis among patients with head and neck cancer undergoing radiotherapy.
authors.affiliation: Nursing Department, School of Health Sciences, University of Brasília, Darcy Ribeiro University Campus, Asa Norte, Brasilia, Federal District, Brazil. elaine.barrosf@gmail.com.
authors.forename: Elaine Barros
authors.initials: EB
authors.lastname: Ferreira
authors.affiliation: Nursing Department, School of Health Sciences, University of Brasília, Darcy Ribeiro University Campus, Asa Norte, Brasilia, Federal District, Brazil.
authors.forename: Christiane Inocêncio
authors.initials: CI
authors.lastname: Vasques
authors.affiliation: Hospital Sírio Libanês, Asa Sul, Brasília, DF, Brazil.
authors.forename: Rafael
authors.initials: R
authors.lastname: Gadia
authors.affiliation: FACN Royal Brisbane and Women's Hospital, Metro North Hospital and Health Service, Queensland University of Technology, QLD, Kelvin Grove, 4059, Australia.
authors.forename: Raymond Javan
authors.initials: RJ
authors.lastname: Chan
authors.affiliation: Nursing Department, School of Health Sciences, University of Brasília, Darcy Ribeiro University Campus, Asa Norte, Brasilia, Federal District, Brazil.
authors.forename: Eliete Neves Silva
authors.initials: EN
authors.lastname: Guerra
authors.affiliation: Federal University of Santa Catarina, Rua Engenheiro Agronômo Andrey Cristian Ferreira, Trindade, Florianópolis, Santa Catarina, Brazil.
authors.forename: Luis André
authors.initials: LA
authors.lastname: Mezzomo
authors.affiliation: Federal University of Santa Catarina, Rua Engenheiro Agronômo Andrey Cristian Ferreira, Trindade, Florianópolis, Santa Catarina, Brazil.
authors.forename: Graziela
authors.initials: G
authors.lastname: De Luca Canto
authors.affiliation: Nursing Department, School of Health Sciences, University of Brasília, Darcy Ribeiro University Campus, Asa Norte, Brasilia, Federal District, Brazil.
authors.forename: Paula Elaine Diniz
authors.initials: PE
authors.lastname: Dos Reis
mesh_terms: D000287:Administration, Topical; D003879:Dermatologic Agents / Q000008:administration & dosage; D006258:Head and Neck Neoplasms / Q000532:radiotherapy*; D006801:Humans; D011855:Radiodermatitis / Q000188:drug therapy / Q000517:prevention & control*; D016032:Randomized Controlled Trials as Topic; D017592:Skin Care / Q000379:methods
chemical_list: D003879:Dermatologic Agents
keywords: Head and neck cancer; Radiodermatitis; Radiotherapy; Skin care