title: Recurrent nephrolithiasis associated with keratinizing desquamative squamous metaplasia.
abstract: Keratinizing desquamative squamous metaplasia (KDSM) in the renal pelvis is a rare condition with unclear malignant potential. Recent reports suggest it is likely benign and favor endoscopic treatment approaches. Medical record review was completed on two cases at our center to obtain history, physical examination, radiographic findings, and management. A literature review was completed to identify all published cases of KDSM. Both patients at our center suffered recurrent urolithiasis, hypothesized to be secondary to KDSM. Both were managed with a percutaneous approach to ensure complete stone and KDSM plaque removal. Our cases highlight that percutaneous surgery is an excellent management option for stone and KDSM eradication from the collecting system. This approach also allows adequate oncologic surveillance of the underlying urothelium.
authors.affiliation: Division of Urology, Department of Surgery, The Ottawa Hospital and University of Ottawa, Ottawa, Ontario, Canada.
authors.forename: Ryan
authors.initials: R
authors.lastname: Fitzpatrick
authors.forename: Luke F
authors.initials: LF
authors.lastname: Reynolds
authors.forename: James D
authors.initials: JD
authors.lastname: Watterson
authors.forename: Luke T
authors.initials: LT
authors.lastname: Lavallée
authors.forename: Trevor A
authors.initials: TA
authors.lastname: Flood
mesh_terms: D001706:Biopsy / Q000379:methods; D005260:Female; D006801:Humans; D007633:Keratins / Q000378:metabolism; D007682:Kidney Pelvis / Q000000981:diagnostic imaging / Q000473:pathology; D008096:Lithotripsy / Q000379:methods; D008297:Male; D008679:Metaplasia; D008875:Middle Aged; D053040:Nephrolithiasis / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery; D012008:Recurrence; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome; D019459:Urothelium / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology
chemical_list: D007633:Keratins