title: Association Between TNF-α -308G/A Polymorphism and Risk of Immune Thrombocytopenia: A Meta-Analysis.
abstract: OBJECTIVE
  Previous studies have investigated the association between tumor necrosis factor-alpha (TNF-α) -308G/A polymorphism and risk of immune thrombocytopenia (ITP), but the reported results have been inconsistent. Thus, a systematic meta-analysis was performed to resolve this discrepancy.
  
  
  METHODS
  Electronic databases and the cited references of the obtained published articles were manually searched. Quality assessment of each study was conducted using the Newcastle-Ottawa Scale (NOS). All case-control studies were used to assess the strength of the association. Statistical analysis was performed using Stata version 12.0.
  
  
  RESULTS
  Eight high-quality studies, including 947 patients and 1911 controls, were selected for the final meta-analysis. There was no significant association between TNF-α -308G/A polymorphism and ITP in overall and Asian populations. However, a significant positive association was observed between them in the dominant genetic model (AA+AG versus GG) in the Caucasian population (OR = 1.35, 95% confidence interval [CI]: 1.07-1.71, PH= 0.173).
  
  
  CONCLUSIONS
  Our finding suggested that TNF-α -308G/A might be involved in development of ITP in the Caucasian population, but not in the Asian population. Among Caucasians the A allele (AA+AG) was associated with ITP. However, larger-scale studies are required to confirm our findings.
authors.affiliation: 1 Department of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University , Nanchang, China .
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: 1 Department of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University , Nanchang, China .
authors.forename: Qing-Hua
authors.initials: QH
authors.lastname: Min
authors.affiliation: 1 Department of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University , Nanchang, China .
authors.forename: Yan-Mei
authors.initials: YM
authors.lastname: Xu
authors.affiliation: 2 Institute of Translational Medicine, Nanchang University , Nanchang, China .
authors.forename: Li-Bing
authors.initials: LB
authors.lastname: Deng
authors.affiliation: 1 Department of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University , Nanchang, China .
authors.forename: Wei-Ming
authors.initials: WM
authors.lastname: Yang
authors.affiliation: 1 Department of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University , Nanchang, China .
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: 1 Department of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University , Nanchang, China .
authors.forename: Shu-Qi
authors.initials: SQ
authors.lastname: Li
authors.affiliation: 3 Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University , Nanchang, China .
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: 1 Department of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University , Nanchang, China .
authors.forename: Jing
authors.initials: J
authors.lastname: Lin
authors.affiliation: 1 Department of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University , Nanchang, China .
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.affiliation: 1 Department of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University , Nanchang, China .
authors.forename: Bo
authors.initials: B
authors.lastname: Huang
authors.affiliation: 1 Department of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University , Nanchang, China .
authors.forename: Fan
authors.initials: F
authors.lastname: Sun
authors.affiliation: 1 Department of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University , Nanchang, China .
authors.forename: Qiu-Fang
authors.initials: QF
authors.lastname: Gao
authors.affiliation: 2 Institute of Translational Medicine, Nanchang University , Nanchang, China .
authors.forename: Xin
authors.initials: X
authors.lastname: Wen
authors.affiliation: 1 Department of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University , Nanchang, China .
authors.forename: Xiao-Zhong
authors.initials: XZ
authors.lastname: Wang
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000235:genetics*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics* / Q000378:metabolism; D044465:White People / Q000235:genetics
chemical_list: D014409:Tumor Necrosis Factor-alpha
keywords: immune thrombocytopenia; single-nucleotide polymorphism; tumor necrosis factor-alpha