title: HIV Drug Resistance and Phylogeny Profile in Naïve and Antiretroviral-Experienced Patients in Tehran, Iran.
abstract: BACKGROUND
  Increasing the accessibility of antiretroviral therapy (ART) has caused the emergence of drug resistance in patients receiving ART and in naïve patients. The aim of this study was to evaluate HIV subtype and drug resistance between naïve patients and ART-experienced patients.
  
  
  METHODS
  Blood samples were collected from 78 antiretroviral and naïve HIV-1 patients; antiretroviral-resistant mutations and subtyping were then determined by sequencing pol regions.
  
  
  RESULTS
  Phylogenetic analysis revealed that 96.1% of sequences belong to the CRF35-AD subtype. Transmitted drug resistance was determined in 14% of drug-naïve patients and 40% of ART-experienced patients.
  
  
  CONCLUSIONS
  The findings of this study illustrated the importance of resistance testing before and during ART treatment. This study can be used to set up a best medicine strategy in Iranian guidelines.
authors.affiliation: Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Molood
authors.initials: M
authors.lastname: Farrokhi
authors.forename: Samaneh
authors.initials: S
authors.lastname: Moallemi
authors.forename: Kazem
authors.initials: K
authors.lastname: Baesi
authors.forename: Sara
authors.initials: S
authors.lastname: Ahsani-Nasab
authors.forename: Mohammad
authors.initials: M
authors.lastname: Gholami
authors.forename: Leila
authors.initials: L
authors.lastname: Sadeghi
authors.forename: Minoo
authors.initials: M
authors.lastname: Mohraz
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000494:pharmacology / Q000627:therapeutic use*; D060085:Coinfection / Q000453:epidemiology / Q000821:virology; D003430:Cross-Sectional Studies; D024882:Drug Resistance, Viral / Q000235:genetics*; D005260:Female; D015751:Genes, pol; D005838:Genotype; D015658:HIV Infections / Q000188:drug therapy / Q000453:epidemiology / Q000821:virology*; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics*; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009154:Mutation; D010802:Phylogeny; D017422:Sequence Analysis, DNA; D055815:Young Adult
chemical_list: D019380:Anti-HIV Agents