title: Roles of Caspases in Necrotic Cell Death.
abstract: Caspases were originally identified as important mediators of inflammatory response and apoptosis. Recent discoveries, however, have unveiled their roles in mediating and suppressing two regulated forms of necrotic cell death, termed pyroptosis and necroptosis, respectively. These recent advances have significantly expanded our understanding of the roles of caspases in regulating development, adult homeostasis, and host defense response.
authors.affiliation: Department of Cell Biology, Harvard Medical School, 240 Longwood Ave., Boston, MA 02115, USA; Ludwig Cancer Center, Harvard Medical School, 240 Longwood Ave., Boston, MA 02115, USA. Electronic address: jyuan@hms.harvard.edu.
authors.forename: Junying
authors.initials: J
authors.lastname: Yuan
authors.affiliation: Department of Cell Biology, Harvard Medical School, 240 Longwood Ave., Boston, MA 02115, USA; Ludwig Cancer Center, Harvard Medical School, 240 Longwood Ave., Boston, MA 02115, USA.
authors.forename: Ayaz
authors.initials: A
authors.lastname: Najafov
authors.affiliation: CIRI, Inserm U1111, Université Claude Bernard Lyon 1, CNRS UMR5308, École Normale Supérieure de Lyon, Université de Lyon, 69007 Lyon, France.
authors.forename: Bénédicte F
authors.initials: BF
authors.lastname: Py
mesh_terms: D000818:Animals; D017209:Apoptosis; D020169:Caspases / Q000378:metabolism*; D006801:Humans; D007239:Infections / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D007249:Inflammation / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D009336:Necrosis / Q000201:enzymology / Q000378:metabolism*; D000069292:Pyroptosis
chemical_list: D020169:Caspases