title: TTF-1 Expression in Rectal Adenocarcinoma: A Case Report and Review of the Literature.
abstract: Thyroid transcription factor 1 (TTF-1) is considered a highly sensitive and specific marker for primary lung adenocarcinoma. However, in recent years retrospective studies of tumor samples have confirmed that, although rare, TTF-1 can also be expressed in colorectal adenocarcinoma. There are a few case reports of patients with TTF-1-positive colon adenocarcinoma in the medical literature but none of TTF-1-positive rectal adenocarcinoma. Here, we present a case of rectal adenocarcinoma with lung metastasis found to be TTF-1 positive on immunohistochemistry. A review and discussion of the available literature is also included.
authors.affiliation: Department of Hematology and Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USA.
authors.forename: Astrid
authors.initials: A
authors.lastname: Belalcazar
authors.affiliation: Department of Pathology, Emory University, Atlanta, GA, USA.
authors.forename: Uma
authors.initials: U
authors.lastname: Krishnamurti
authors.affiliation: Department of Hematology and Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USA.
authors.forename: Walid
authors.initials: W
authors.lastname: Shaib
keywords: Colorectal adenocarcinoma; Colorectal cancer; Immunohistochemistry; Rectal adenocarcinoma; Rectal cancer; TTF; TTF-1; Thyroid transcription factor