title: A novel electrochemical sensor based on a molecularly imprinted polymer for the determination of epigallocatechin gallate.
abstract: A novel electrochemical sensor based on the molecularly imprinted polymer (MIP) was fabricated by electrochemical polymerization of β-cyclodextrins (β-CD) and epigallocatechin-gallate (EGCG) on the graphene oxide (GO) modified glassy carbon (GO/GC) electrode for the first time. The MIP/GO/GC electrode exhibits an excellent ability of specific binding of EGCG and a rapid electrochemical response, high sensitivity and selectivity for determination of EGCG. This prepared MIP sensor presents distinct advantages over conventional electrochemical methods for EGCG determination because it is a one-step preparation and the template molecule can be easily removed by cyclic voltammetry scans, and no elution reagent is required. Under the optimal experimental conditions, the linear response range for EGCG concentrations by the sensor was 3×10-8mol/L to 1×10-5mol/L and the detection limit was 8.78×10-9mol/L(S/N=3). The results demonstrate that the proposed MIP sensor can be a potential alternative for the determination of EGCG in tea samples.
authors.affiliation: College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210046, China.
authors.forename: Yanrui
authors.initials: Y
authors.lastname: Liu
authors.affiliation: College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210046, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Zhu
authors.affiliation: College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210046, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Hu
authors.affiliation: College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210046, China.
authors.forename: Xinsheng
authors.initials: X
authors.lastname: Peng
authors.affiliation: College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210046, China; Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Nanjing 210046, China. Electronic address: dujiangyan@njnu.edu.cn.
authors.forename: Jiangyan
authors.initials: J
authors.lastname: Du
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods*; D028241:Camellia sinensis / Q000737:chemistry; D002244:Carbon / Q000737:chemistry; D002392:Catechin / Q000031:analogs & derivatives* / Q000032:analysis; D055664:Electrochemical Techniques / Q000295:instrumentation / Q000379:methods*; D004566:Electrodes; D006108:Graphite / Q000737:chemistry; D057230:Limit of Detection; D054802:Molecular Imprinting / Q000379:methods*; D010087:Oxides; D018515:Plant Leaves / Q000737:chemistry; D058105:Polymerization; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D047392:beta-Cyclodextrins / Q000737:chemistry
chemical_list: D010087:Oxides; D011108:Polymers; D047392:beta-Cyclodextrins; D002244:Carbon; D006108:Graphite; D002392:Catechin; C045651:epigallocatechin gallate
keywords: EGCG; Electrochemical polymerization; Molecularly imprinted polymer; Sensor; β-CD