title: A highly selective and sensitive turn-on fluorescent probe for the detection of Al3+and its bioimaging.
abstract: A novel fluorescent sensor, 1-((2-hydroxynaphthalen-1-yl)methylene)urea (ocn) has been designed and applied as a highly selective and sensitive fluorescent probe for recognition of Al3+in Tris-HCl (pH = 7.20) solution. The probe ocn exhibits an excellent selectivity to Al3+over other examined metal ions, anions and amino acids with a prominent fluorescence 'turn-on' at 438 nm. ocn binds to Al3+with a 2:1 binding stoichiometry and the detection limit was 0.3 μM. Furthermore, its capability of biological application was evaluated and the results showed that the sensor could be used to detect Al3+in living cells.
authors.affiliation: School of Pharmacy, Jiangsu Provincial Key Laboratory of Coastal Wetland Bioresources and Environmental Protection, Yancheng Teachers' University, Yancheng, Jiangsu, People's Republic of China.|State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing, People's Republic of China.
authors.forename: Qingming
authors.initials: Q
authors.lastname: Wang
authors.affiliation: School of Pharmacy, Jiangsu Provincial Key Laboratory of Coastal Wetland Bioresources and Environmental Protection, Yancheng Teachers' University, Yancheng, Jiangsu, People's Republic of China.
authors.forename: Lei
authors.initials: L
authors.lastname: Yang
authors.affiliation: School of Pharmacy, Jiangsu Provincial Key Laboratory of Coastal Wetland Bioresources and Environmental Protection, Yancheng Teachers' University, Yancheng, Jiangsu, People's Republic of China.
authors.forename: Hua
authors.initials: H
authors.lastname: Wang
authors.affiliation: School of Pharmacy, Jiangsu Provincial Key Laboratory of Coastal Wetland Bioresources and Environmental Protection, Yancheng Teachers' University, Yancheng, Jiangsu, People's Republic of China.
authors.forename: Jialiang
authors.initials: J
authors.lastname: Song
authors.affiliation: School of Pharmacy, Jiangsu Provincial Key Laboratory of Coastal Wetland Bioresources and Environmental Protection, Yancheng Teachers' University, Yancheng, Jiangsu, People's Republic of China.
authors.forename: Hui
authors.initials: H
authors.lastname: Ding
authors.affiliation: School of Pharmacy, Jiangsu Provincial Key Laboratory of Coastal Wetland Bioresources and Environmental Protection, Yancheng Teachers' University, Yancheng, Jiangsu, People's Republic of China.
authors.forename: Xin-Hui
authors.initials: XH
authors.lastname: Tang
authors.affiliation: School of Pharmacy, Jiangsu Provincial Key Laboratory of Coastal Wetland Bioresources and Environmental Protection, Yancheng Teachers' University, Yancheng, Jiangsu, People's Republic of China.
authors.forename: Hongmiao
authors.initials: H
authors.lastname: Yao
mesh_terms: D000535:Aluminum / Q000032:analysis*; D001665:Binding Sites; D045744:Cell Line, Tumor; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D057230:Limit of Detection; D009682:Magnetic Resonance Spectroscopy; D008670:Metals; D057054:Molecular Imaging / Q000379:methods; D009281:Naphthalenes; D012680:Sensitivity and Specificity; D013050:Spectrometry, Fluorescence / Q000379:methods*; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D014508:Urea / Q000031:analogs & derivatives
chemical_list: C000626825:1-((2-hydroxynaphthalen-1-yl)methylene)urea; D005456:Fluorescent Dyes; D008670:Metals; D009281:Naphthalenes; D014508:Urea; D000535:Aluminum
keywords: Al3+ detection; bioimaging; chemosensor; naphthaldehyde derivative