title: The Efficacy of Intraoperative Frozen Section Analysis During Breast-Conserving Surgery for Patients with Ductal Carcinoma In Situ.
abstract: BACKGROUND
  Recently, the incidence of ductal carcinoma in situ (DCIS), a noninvasive breast malignancy, has increased. This has resulted in an increase in the incidence of breast-conserving surgery (BCS). Numerous studies have suggested that intraoperative frozen section analysis (IFSA) could reduce the rate of additional excisions required to obtain adequate resection margins. However, DCIS is a known risk factor for positive margin status during BCS. Furthermore, some authors have concluded that IFSA may not be reliable for the detection of DCIS.
  
  
  OBJECTIVE
  The aim of this study was to evaluate the safety and efficacy of IFSA in patients with DCIS.
  
  
  METHODS
  The operative and pathological reports of patients with DCIS, who underwent BCS at our institute between 2006 and 2015, were retrospectively reviewed. The results of IFSA and the pathological findings of final reanalyzed frozen tissue specimens were analyzed.
  
  
  RESULTS
  In total, 25 patients were included in our analysis. None of the patients required additional operations. The correct diagnosis rate for IFSA was 89.6%, with a sensitivity and specificity of 60.0% and 95.8%, respectively.
  
  
  CONCLUSIONS
  IFSA could be beneficial for determining safety resection margins in patients with DCIS.
authors.affiliation: Department of General Surgery, Presbyterian Medical Center, Jeonju, Korea.
authors.forename: Mi Jin
authors.initials: MJ
authors.lastname: Kim
authors.affiliation: Department of General Surgery, Presbyterian Medical Center, Jeonju, Korea.
authors.forename: Cheol Seung
authors.initials: CS
authors.lastname: Kim
authors.affiliation: Department of General Surgery, Presbyterian Medical Center, Jeonju, Korea.
authors.forename: Young Sam
authors.initials: YS
authors.lastname: Park
authors.affiliation: Department of General Surgery, Presbyterian Medical Center, Jeonju, Korea.
authors.forename: Eun Hye
authors.initials: EH
authors.lastname: Choi
authors.affiliation: Department of General Surgery, Presbyterian Medical Center, Jeonju, Korea.
authors.forename: Kyu Dam
authors.initials: KD
authors.lastname: Han
keywords: breast-conserving surgery; ductal carcinoma in situ; intraoperative frozen section analysis