title: Sex chromosome abnormalities and psychiatric diseases.
abstract: Excesses of sex chromosome abnormalities in patients with psychiatric diseases have recently been observed. It remains unclear whether sex chromosome abnormalities are related to sex differences in some psychiatric diseases. While studies showed evidence of susceptibility loci over many sex chromosomal regions related to various mental diseases, others demonstrated that the sex chromosome aneuploidies may be the key to exploring the pathogenesis of psychiatric disease. In this review, we will outline the current evidence on the interaction of sex chromosome abnormalities with schizophrenia, autism, ADHD and mood disorders.
authors.affiliation: Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China.
authors.forename: Xinzhu
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Beijing, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Yang
authors.affiliation: Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China.|Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Beijing, China.
authors.forename: Yuhong
authors.initials: Y
authors.lastname: Li
authors.affiliation: Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China.|Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Beijing, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Ma
authors.affiliation: Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China.|Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Beijing, China.|Center for Hormone Advanced Science and Education, Roskamp Institute, Sarasota, FL, USA.
authors.forename: Rena
authors.initials: R
authors.lastname: Li
mesh_terms: D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics*; D001321:Autistic Disorder / Q000235:genetics*; D041321:Chromosomes, Human, X / Q000235:genetics; D041322:Chromosomes, Human, Y / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics*; D012729:Sex Chromosome Aberrations
keywords: ADHD; autism; depression; gender; schizophrenia