title: Pilot Study of Lamina Cribrosa Intensity Measurements in Glaucoma Using Swept-Source Optical Coherence Tomography.
abstract: OBJECTIVE
  To compare the lamina cribrosa (LC) intensity in glaucoma-suspect eyes and eyes with mild to moderate glaucoma using swept-source optical coherence tomography.
  
  
  METHODS
  Optic disc volume scans were collected using swept-source optical coherence tomography in 19 clinically defined glaucoma-suspect eyes and 29 eyes with mild to moderate glaucoma. LC intensity was measured using Image J software, and the resultant values were normalized using the retinal pigment epithelium and vitreous signal.
  
  
  RESULTS
  Mean age was 53.7±18.5 years in the glaucoma-suspect eyes and 63.0±16.1 years in the eyes with mild to moderate glaucoma (P=0.161). Significant differences in LC intensity were observed between the 2 groups, with median LC intensity values of 0.96 and 0.86 units in the glaucoma-suspect and the mild to moderate glaucoma groups, respectively (P<0.001). A weak positive correlation was found between mean deviation and normalized LC intensity (r=0.344; P=0.018).
  
  
  CONCLUSIONS
  Intensity measurement of the LC is a potential novel parameter which warrants further study in the setting of glaucoma.
authors.affiliation: *Doheny Image Reading Center, Doheny Eye Institute ‡Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles †Carl Zeiss Meditec Inc., Dublin, CA.
authors.forename: Sowmya
authors.initials: S
authors.lastname: Srinivas
authors.forename: Anna
authors.initials: A
authors.lastname: Dastiridou
authors.forename: Mary K
authors.initials: MK
authors.lastname: Durbin
authors.forename: Muneeswar G
authors.initials: MG
authors.lastname: Nittala
authors.forename: Alex A
authors.initials: AA
authors.lastname: Huang
authors.forename: James C H
authors.initials: JC
authors.lastname: Tan
authors.forename: Brian A
authors.initials: BA
authors.lastname: Francis
authors.forename: Srinivas R
authors.initials: SR
authors.lastname: Sadda
authors.forename: Vikas
authors.initials: V
authors.lastname: Chopra
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005902:Glaucoma, Open-Angle / Q000473:pathology*; D006068:Gonioscopy; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000473:pathology; D009898:Optic Disk / Q000473:pathology*; D010865:Pilot Projects; D011446:Prospective Studies; D055213:Retinal Pigment Epithelium / Q000473:pathology; D041623:Tomography, Optical Coherence / Q000379:methods*