title: Histological evaluation of mineral trioxide aggregate and enamel matrix derivative combination in direct pulp capping: Anin vivostudy.
abstract: OBJECTIVE
  The aim of this study is to evaluate the response of human pulp tissue to mineral trioxide aggregate (MTA), Emdogain (EMD), and combination of MTA/EMD.
  
  
  METHODS
  This study was performed on sixty intact first and second premolars of human maxillary and mandibular teeth. A standard pulpal exposure was done on all the teeth and was divided into three groups of twenty teeth each and was capped with MTA, EMD, and MTA/EMD combination. The final restoration was done with resin-modified glass ionomer cement. The teeth were then extracted on the 15thor 45thday and histological evaluation done.
  
  
  RESULTS
  Differences in inflammatory response and thickness of dentin bridge formation of the exposed pulp to the three different groups were statistically evaluated using Chi-square and Mann-Whitney tests and were found to be significant. No significant difference was found between MTA/EMD and MTA in terms of calcified bridge formation and pulp inflammatory response to the capping materials.
  
  
  CONCLUSIONS
  MTA and MTA/EMD combination produced a better quality hard tissue response compared with the use of EMD.
authors.affiliation: Department of Conservative Dentistry and Endodontics, St. Joseph Dental College and Hospital, Eluru, Andhra Pradesh, India.
authors.forename: Indira Priyadarshini
authors.initials: IP
authors.lastname: Bollu
authors.affiliation: Department of Conservative Dentistry and Endodontics, Lenora Institute of Dental Sciences, Rajahmundry, Andhra Pradesh, India.
authors.forename: L Deepa
authors.initials: LD
authors.lastname: Velagula
authors.affiliation: Department of Conservative Dentistry and Endodontics, Sibar Institute of Dental Sciences, Guntur, Andhra Pradesh, India.
authors.forename: Nagesh
authors.initials: N
authors.lastname: Bolla
authors.affiliation: Department of Oral and Maxillofacial Pathology, Sibar Institute of Dental Sciences, Guntur, Andhra Pradesh, India.
authors.forename: K Kiran
authors.initials: KK
authors.lastname: Kumar
authors.affiliation: Department of Periodontics, St. Joseph Dental College and Hospital, Eluru, Andhra Pradesh, India.
authors.forename: Archana
authors.initials: A
authors.lastname: Hari
authors.affiliation: Department of Conservative Dentistry and Endodontics, St. Joseph Dental College and Hospital, Eluru, Andhra Pradesh, India.
authors.forename: Jayaprakash
authors.initials: J
authors.lastname: Thumu
keywords: Calcific bridge; direct pulp capping; enamel matrix derivative; histological evaluation; inflammatory response; mineral trioxide aggregate