title: Cerebral open flow microperfusion (cOFM) an innovative interface to brain tissue.
abstract: Cerebral open flow microperfusion (cOFM) is a new in-vivo technique for continuous sampling of the interstitial fluid in brain tissue. cOFM can be used to monitor substance transport across the blood-brain barrier (pharmacokinetics) and to investigate metabolic changes in brain tissue after drug application (pharmacodynamics). The possibility of long-term implantation into the brain makes cOFM an outstanding tool in the development of brain relevant pharmaceutics.
authors.affiliation: Joanneum Research GmbH, HEALTH - Institute for Biomedicine and Health Sciences, Neue Stiftingtalstrasse 2, 8010 Graz, Austria. Electronic address: ca.health@joanneum.at.
authors.forename: Thomas
authors.initials: T
authors.lastname: Birngruber
authors.affiliation: Joanneum Research GmbH, HEALTH - Institute for Biomedicine and Health Sciences, Neue Stiftingtalstrasse 2, 8010 Graz, Austria; Medical University of Graz, Department of Internal Medicine, Division of Endocrinology and Diabetology, Auenbruggerplatz 15, 8036 Graz, Austria.
authors.forename: Frank
authors.initials: F
authors.lastname: Sinner
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D055616:Microtechnology / Q000295:instrumentation / Q000379:methods; D010477:Perfusion / Q000295:instrumentation / Q000379:methods*; D010599:Pharmacokinetics; D002620:Pharmacological and Toxicological Phenomena