title: Poly(aryleneethynylene) Tongue That Identifies Nonsteroidal Anti-Inflammatory Drugs in Water: A Test Case for Combating Counterfeit Drugs.
abstract: We report a sensor array composed of a highly fluorescent positively charged poly(para-phenyleneethynylene) P1 and its complex C with a negatively charged pyridine-containing poly(para-aryleneethynylene) P2 (quencher) at pH 10 and pH 13; a sensor field composed of four elements, P1 (pH 10), P1 (pH 13), C (pH 10), and C (pH 13), results. The elements of this small sensor field experience either fluorescence turn on or fluorescence quenching upon exposure toward nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin, ibuprofen, diclofenac, or naproxen. The combined responses of the sensor field are analyzed by linear discriminant analysis (LDA). All of the NSAIDs were identified and discriminated, and the sensing mechanism, hydrophobic versus electrostatic, was discussed.
authors.affiliation: Organisch-Chemisches Institut, Ruprecht-Karls-Universität Heidelberg , Im Neuenheimer Feld 270, 69120 Heidelberg, Germany.
authors.forename: Jinsong
authors.initials: J
authors.lastname: Han
authors.affiliation: Organisch-Chemisches Institut, Ruprecht-Karls-Universität Heidelberg , Im Neuenheimer Feld 270, 69120 Heidelberg, Germany.
authors.forename: Benhua
authors.initials: B
authors.lastname: Wang
authors.affiliation: Organisch-Chemisches Institut, Ruprecht-Karls-Universität Heidelberg , Im Neuenheimer Feld 270, 69120 Heidelberg, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Bender
authors.affiliation: Organisch-Chemisches Institut, Ruprecht-Karls-Universität Heidelberg , Im Neuenheimer Feld 270, 69120 Heidelberg, Germany.
authors.forename: Soh
authors.initials: S
authors.lastname: Kushida
authors.affiliation: Organisch-Chemisches Institut, Ruprecht-Karls-Universität Heidelberg , Im Neuenheimer Feld 270, 69120 Heidelberg, Germany.
authors.forename: Kai
authors.initials: K
authors.lastname: Seehafer
authors.affiliation: Organisch-Chemisches Institut, Ruprecht-Karls-Universität Heidelberg , Im Neuenheimer Feld 270, 69120 Heidelberg, Germany.|CAM, Centre for Advanced Materials, Ruprecht-Karls-Universität Heidelberg , Im Neuenheimer Feld 225, 69120 Heidelberg, Germany.
authors.forename: Uwe H F
authors.identifier: http://orcid.org/0000-0002-9369-5387
authors.initials: UH
authors.lastname: Bunz
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D058110:Counterfeit Drugs; D004008:Diclofenac; D007052:Ibuprofen; D009288:Naproxen; D014867:Water
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D058110:Counterfeit Drugs; D014867:Water; D004008:Diclofenac; D009288:Naproxen; D007052:Ibuprofen
keywords: chemical tongue; conjugated polymer; linear discriminant analysis; nonsteroidal anti-inflammatory drugs; sensor