title: Biopsy of the sentinel node in lung cancer.
abstract: OBJECTIVE
  Mediastinal lymph node involvement can be understaged in cases of lung cancer (up to 20% in stage i). Sentinel node detection is a standard technique recommended in breast cancer and melanoma action guidelines, and could also be useful in cases of lung cancer.
  
  
  METHODS
  Considering the detection of the sentinel node in non-small cell lung cancer (NSCLC) as feasible, a prospective cohort study was carried out on 48 patients with resectable NSCLC, using the intraoperative injection of colloid sulphate technetium-99.
  
  
  RESULTS
  The radioisotope migrated in all cases. The procedure's sensitivity was 88.24%, its accuracy was 95.83%, its negative predictive value was 93.94% and the false negative rate was 11.76%. No complications were associated with this technique.
  
  
  CONCLUSIONS
  The detection of a sentinel node in NSCLC with the intraoperative injection of the isotope is feasible and safe, and allows for detection and sensitivity rates comparable to those of other tumour types.
authors.affiliation: Servicio de Cirugía Torácica, Hospital Universitario de Cruces, Barakaldo, Vizcaya, España. Electronic address: naia.uribe-etxebarrialugariza-aresti@osakidetza.eus.
authors.forename: Naia
authors.initials: N
authors.lastname: Uribe-Etxebarria Lugariza-Aresti
authors.affiliation: Servicio de Oncología Médica, Hospital Universitario de Basurto, Bilbao, Vizcaya, España.
authors.forename: Ramón
authors.initials: R
authors.lastname: Barceló Galíndez
authors.affiliation: Servicio de Cirugía Torácica, Hospital Universitario de Cruces, Barakaldo, Vizcaya, España.
authors.forename: Joaquín
authors.initials: J
authors.lastname: Pac Ferrer
authors.affiliation: Servicio de Cirugía General, Hospital Universitario de Basurto, Bilbao, Vizcaya, España.
authors.forename: Jaime
authors.initials: J
authors.lastname: Méndez Martín
authors.affiliation: Servicio de Medicina Nuclear, Hospital Universitario de Cruces, Barakaldo, Vizcaya, España.
authors.forename: Jose
authors.initials: J
authors.lastname: Genollá Subirats
authors.affiliation: Servicio de Cirugía Torácica, Hospital Universitario de Cruces, Barakaldo, Vizcaya, España.
authors.forename: Juan
authors.initials: J
authors.lastname: Casanova Viudez
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007430:Intraoperative Care / Q000379:methods*; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D008207:Lymphatic Metastasis; D008297:Male; D008482:Mediastinum; D008875:Middle Aged; D011446:Prospective Studies; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012680:Sensitivity and Specificity; D021701:Sentinel Lymph Node Biopsy / Q000379:methods*; D013671:Technetium Tc 99m Sulfur Colloid
chemical_list: D019275:Radiopharmaceuticals; D013671:Technetium Tc 99m Sulfur Colloid
keywords: Cáncer de pulmón; Ganglio centinela; Lung cancer; Micrometastasis; Micrometástasis; Sentinel node; Skip metastases; Skip metástasis