title: [Influence of chromosomal polymorphisms on the clinical outcome of patients undergoing in vitro fertilization embryo transfer].
abstract: OBJECTIVE
  To explore the influence of chromosome polymorphisms on the outcome of in vitro fertilization embryo transfer (IVF-ET).
  
  
  METHODS
  Patients who completed the first cycle of in vitro fertilization fresh embryo transfer were retrospective studied. Patients with the chromosome polymorphisms were classified as to the study group (200 treatment cycles), all patients with normal chromosomes at the same period were classified as the control group (4777 treatment cycles).
  
  
  RESULTS
  No significant difference was found between the chromosome polymorphisms and the control groups in terms of clinical pregnancy rate (44.50% vs. 39.85%, P=0.750), early abortion rate (15.73% vs. 10.79%, P=0.163) and live birth rate per cycle (34.5% vs. 30.73%, P=0.437) except for fertilization rate (60.94% vs. 64.08%, P=0.001), cleavage rate (95.01% vs. 97.09%, P=0.000) and good quality embryo rate (53.8% vs. 58.2%, P=0.001).
  
  
  CONCLUSIONS
  Chromosomal polymorphisms appeared to have no adverse influence on the outcome of IVF-ET treatment.
authors.affiliation: Reproductive Medical Center of Xiangya Hospital, Central South University, Changsha, Hunan 410008, China. liyumei7511@163.com.
authors.forename: Yumei
authors.initials: Y
authors.lastname: Li
authors.forename: Donge
authors.initials: D
authors.lastname: Liu
authors.forename: Zhongyuan
authors.initials: Z
authors.lastname: Yao
authors.forename: Lingqian
authors.initials: L
authors.lastname: Wu
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000235:genetics*; D004624:Embryo Transfer / Q000379:methods; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D011247:Pregnancy; D011256:Pregnancy Outcome