title: Genetic Analysis Workshop 19: methods and strategies for analyzing human sequence and gene expression data in extended families and unrelated individuals.
abstract: Genetic Analysis Workshop 19 provided a platform for developing and evaluating statistical methods to analyze whole-genome sequence and gene expression data from a pedigree-based sample, as well as whole-exome sequence data from a large cohort of unrelated individuals. In this article we present an overview of the data sets, the GAW experience, and summaries of the contributions arranged into nine methodological themes.
authors.affiliation: Department of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin, 610 Walnut Street, 707 WARF, Madison, WI 53726 USA.
authors.forename: Corinne D
authors.initials: CD
authors.lastname: Engelman
authors.affiliation: Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Côte Ste. Catherine, Montreal, QC H3T 1E2 Canada.
authors.forename: Celia M T
authors.initials: CM
authors.lastname: Greenwood
authors.affiliation: Department of Epidemiology, University of California Los Angeles Fielding School of Public Health, Box 951772, Los Angeles, CA 90095 USA.
authors.forename: Julia N
authors.initials: JN
authors.lastname: Bailey
authors.affiliation: Department of Human Genetics, David Geffen School of Medicine at UCLA, 695 Charles E. Young Dr, South, Los Angeles, CA 90024-7088 USA.
authors.forename: Rita M
authors.initials: RM
authors.lastname: Cantor
authors.affiliation: Department of Genetics, Texas Biomedical Research Institute, PO Box 760549, San Antonio, TX 78245-0549 USA.
authors.forename: Jack W
authors.initials: JW
authors.lastname: Kent
authors.affiliation: Institut für Medizinische Biometrie und Statistik, Universität zu Lübeck, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.
authors.forename: Inke R
authors.initials: IR
authors.lastname: König
authors.affiliation: Statistical Genetics Group, Institute of Medical Biometry and Informatics, University of Heidelberg, Im Neuenheimer Feld 305, 69120 Heidelberg, Germany.
authors.forename: Justo Lorenzo
authors.initials: JL
authors.lastname: Bermejo
authors.affiliation: Centre for Genetic Origins of Health and Disease, University of Western Australia, Perth, WA Australia.
authors.forename: Phillip E
authors.initials: PE
authors.lastname: Melton
authors.affiliation: Department of Mathematical & Statistical Sciences, University of Colorado-Denver, PO Box 173364, Denver, CO 80204 USA.
authors.forename: Stephanie A
authors.initials: SA
authors.lastname: Santorico
authors.affiliation: Institut für Medizinische Biometrie und Statistik, Universität zu Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany.
authors.forename: Arne
authors.initials: A
authors.lastname: Schillert
authors.affiliation: Department of Medicine, Department of Biostatistics, Division of Medical Genetics, University of Washington, Seattle, WA 98195 USA.
authors.forename: Ellen M
authors.initials: EM
authors.lastname: Wijsman
authors.affiliation: Department of Genetics, Texas Biomedical Research Institute, PO Box 760549, San Antonio, TX 78245-0549 USA.
authors.forename: Jean W
authors.initials: JW
authors.lastname: MacCluer
authors.affiliation: South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, San Antonio, TX 78229 USA.
authors.forename: Laura
authors.initials: L
authors.lastname: Almasy