title: Association of betatrophin with metabolic characteristics in overweight/obese and lean women with PCOS.
abstract: As a new hormone, betatrophin has gained attention as a potential new target to combat insulin resistance (IR) and diabetes. Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder among women of the reproductive age with long term sequelae which include IR and metabolic syndrome. The aim of this study is to evaluate the circulating plasma betatrophin levels in overweight/obese or lean women with or without PCOS and also to elucidate possible correlations with anthropometric and metabolic parameters. Thirty-two patients with PCOS as well as fifty-three control subjects were enrolled after obtaining informed written consent. Clinical and biochemical parameters of all subjects were determined. Plasma adiponectin, GLP-1 and betatrophin levels were measured by ELISA. Plasma betatrophin levels were significantly increased in lean patients with PCOS compared with lean and obese controls. Moreover, in PCOS group, betatrophin levels were significantly negatively correlated with waist hip ratio (WHR), fasting insulin level (FINS) and HOMA-IR, whereas, significantly positively correlated with adiponectin level. Multiple regression analysis showed that HOMA-IR was an independent factor influencing serum betatrophin levels. Further follow-up studies are needed to highlight whether and how increased betatrophin secretion play an important role in IR and carbohydrates metabolism in patients with PCOS.
authors.affiliation: a Department of Obstetrics and Gynecology , Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai , China.
authors.forename: Linxia
authors.initials: L
authors.lastname: Li
authors.affiliation: b State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University , Shanghai , China.|c Clinical Laboratory, the Third Affiliated Hospital, Nantong University , Wuxi , China.
authors.forename: Feng
authors.initials: F
authors.lastname: Zhang
authors.affiliation: d Department of Obstetrics and Gynecology , Traditional Chinese Medicine Hospital of Kunshan , Jiangsu , China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Cui
authors.affiliation: e Department of Endocrinology and Metabolism , Qidong People's Hospital , Jiangsu , China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Shi
authors.affiliation: a Department of Obstetrics and Gynecology , Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai , China.
authors.forename: Jiangdong
authors.initials: J
authors.lastname: Xiang
authors.affiliation: a Department of Obstetrics and Gynecology , Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai , China.
authors.forename: Xuejiao
authors.initials: X
authors.lastname: Wang
authors.affiliation: f Department of Public Health and Community Medicine , Tufts University School of medicine , MA , USA , and.
authors.forename: Naisi
authors.initials: N
authors.lastname: Zhao
authors.affiliation: g Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University , Medford , MA , USA.
authors.forename: Qingwu
authors.initials: Q
authors.lastname: Yan
authors.affiliation: g Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University , Medford , MA , USA.
authors.forename: Andrew S
authors.initials: AS
authors.lastname: Greenberg
authors.affiliation: a Department of Obstetrics and Gynecology , Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai , China.
authors.forename: Yongde
authors.initials: Y
authors.lastname: Peng
authors.affiliation: a Department of Obstetrics and Gynecology , Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai , China.|g Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University , Medford , MA , USA.
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Ding
mesh_terms: D052242:Adiponectin / Q000097:blood; D000293:Adolescent; D000328:Adult; D000091306:Angiopoietin-Like Protein 8; D000075802:Angiopoietin-like Proteins; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002681:China; D003430:Cross-Sectional Studies; D005260:Female; D052216:Glucagon-Like Peptide 1 / Q000097:blood; D006801:Humans; D007333:Insulin Resistance; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000150:complications / Q000378:metabolism; D050177:Overweight / Q000097:blood* / Q000150:complications / Q000378:metabolism; D036361:Peptide Hormones / Q000097:blood* / Q000378:metabolism; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications / Q000378:metabolism; D017697:Premenopause; D013851:Thinness / Q000097:blood / Q000150:complications / Q000378:metabolism; D049629:Waist-Hip Ratio; D055815:Young Adult
chemical_list: C499918:ADIPOQ protein, human; C576683:ANGPTL8 protein, human; D052242:Adiponectin; D000091306:Angiopoietin-Like Protein 8; D000075802:Angiopoietin-like Proteins; D015415:Biomarkers; D036361:Peptide Hormones; D052216:Glucagon-Like Peptide 1
keywords: Betatrophin; insulin resistance; lean; obese; polycystic ovary syndrome