title: In Vivo Detoxification of Lipopolysaccharide by Antimicrobial Peptides.
abstract: Abundant lipopolysaccharide (LPS) can result in sepsis and septic shock, indicating a serious Gram-negative bacterial contamination. We have developed a novel strategy based on dendritic antimicrobial peptides that can detoxify LPS. The dendritic antimicrobial peptides bind to LPS at the surface of Gram-negative bacteria, killing the bacteria but removing the LPS from the cell wall of dead Gram-negative bacteria, hence detoxifying pathogenic bacteria in its host cells and effectively improving survival of animals infected with Pseudomonas aeruginosa. Our findings provide a way to detoxify bacterial contamination.
authors.affiliation: Key Laboratory for Advanced Materials & Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology , Shanghai 200237, China.
authors.forename: Wenxu
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Key Laboratory for Advanced Materials & Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology , Shanghai 200237, China.
authors.forename: Jiangcheng
authors.initials: J
authors.lastname: He
authors.affiliation: Key Laboratory for Advanced Materials & Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology , Shanghai 200237, China.
authors.forename: Junchen
authors.identifier: 0000-0002-2200-0269
authors.initials: J
authors.lastname: Wu
authors.affiliation: Institute for Organic Chemistry University of Duisburg-Essen , 47057 Essen, Germany.
authors.forename: Carsten
authors.initials: C
authors.lastname: Schmuck
mesh_terms: D000072283:A549 Cells; D000595:Amino Acid Sequence; D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008070:Lipopolysaccharides / Q000378:metabolism* / Q000633:toxicity*; D051379:Mice; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000378:metabolism / Q000502:physiology
chemical_list: D023181:Antimicrobial Cationic Peptides; D008070:Lipopolysaccharides