title: Initial accuracy assessment of the modified S-LANSS for the detection of neuropathic orofacial pain conditions.
abstract: OBJECTIVE
  To evaluate the accuracy of a questionnaire modified for the identification of intraoral pain with neuropathic characteristics in a clinical orofacial pain sample population.
  
  
  METHODS
  136 participants with at least one of four orofacial pain diagnoses (temporomandibular disorders [TMD, n = 41], acute dental pain [ADP, n = 41], trigeminal neuralgia [TN, n = 19], persistent dentoalveolar pain disorder [PDAP, n = 14]) and a group of pain-free controls (n = 21) completed the modified S-LANSS, a previously adapted version of the original questionnaire devised to detected patients suffering from intraoral pain with neuropathic characteristics. Psychometric properties (sensitivity, specificity, positive predictive value [PPV], negative predictive value [NPV]) were calculated in two analyses with two different thresholds: (1) Detection of pain with neuropathic characteristics: PDAP + TN were considered positive, and TMD + ADP + controls were considered negative per gold standard (expert opinion). (2) Detection of PDAP: PDAP was considered positive and TMD + ADP were considered negative per gold standard. For both analyses, target values for adequate sensitivity and specificity were defined as ≥ 80%.
  
  
  RESULTS
  For detection of orofacial pain with neuropathic characteristics (PDAP + TN), the modified S-LANSS presented with the most optimistic threshold sensitivity of 52% (95% confidence interval [CI], 34-69), specificity of 70% (95% CI, 60-79), PPV of 35% (95% CI, 22-51), and NPV of 82% (95% CI, 72-89). For detection of PDAP only, with the most optimistic threshold sensitivity was 64% (95% CI, 35-87), specificity 63% (95% CI, 52-74), PPV 23% (95% CI, 11-39) and NPV 91% (95% CI, 81-97).
  
  
  CONCLUSIONS
  Based on a priori defined criteria, the modified S-LANSS did not show adequate accuracy to detect intraoral pain with neuropathic characteristics in a clinical orofacial pain sample.
authors.forename: Alberto
authors.initials: A
authors.lastname: Herrero Babiloni
authors.forename: Donald R
authors.initials: DR
authors.lastname: Nixdorf
authors.forename: Alan S
authors.initials: AS
authors.lastname: Law
authors.forename: Estephan J
authors.initials: EJ
authors.lastname: Moana-Filho
authors.forename: Sarah S
authors.initials: SS
authors.lastname: Shueb
authors.forename: Ruby H
authors.initials: RH
authors.lastname: Nguyen
authors.forename: Justin
authors.initials: J
authors.lastname: Durham
mesh_terms: D016022:Case-Control Studies; D005157:Facial Pain / Q000175:diagnosis* / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009437:Neuralgia / Q000175:diagnosis* / Q000209:etiology*; D010147:Pain Measurement / Q000379:methods*; D011594:Psychometrics; D015203:Reproducibility of Results