title: Plasmodium vivax Controlled Human Malaria Infection - Progress and Prospects.
abstract: Modern controlled human malaria infection (CHMI) clinical trials have almost entirely focussed on Plasmodium falciparum, providing a highly informative means to investigate host-pathogen interactions as well as assess potential new prophylactic and therapeutic interventions. However, in recent years, there has been renewed interest in Plasmodium vivax, with CHMI models developed by groups in Colombia, the USA, and Australia. This review summarizes the published experiences, and examines the advantages and disadvantages of the different models that initiate infection either by mosquito bite or using a blood-stage inoculum. As for P. falciparum, CHMI studies with P. vivax will provide a platform for early proof-of-concept testing of drugs and vaccines, accelerating the development of novel interventions.
authors.affiliation: The Jenner Institute Laboratories, Old Road Campus Research Building, University of Oxford, Oxford, OX3 7DQ, UK; The Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Oxford, OX3 7LE, UK. Electronic address: ruth.payne@ndm.ox.ac.uk.
authors.forename: Ruth O
authors.initials: RO
authors.lastname: Payne
authors.affiliation: QIMR Berghofer Medical Research Institute, 300 Herston Rd, Herston, Queensland 4006, Australia; Q-Pharm Pty Ltd, Brisbane, Australia; Department of Medicine and Infectious Diseases, Mater Hospital and Mater Medical Research Institute, Brisbane, Australia; The University of Queensland, Brisbane, Australia.
authors.forename: Paul M
authors.initials: PM
authors.lastname: Griffin
authors.affiliation: QIMR Berghofer Medical Research Institute, 300 Herston Rd, Herston, Queensland 4006, Australia; The University of Queensland, Brisbane, Australia.
authors.forename: James S
authors.initials: JS
authors.lastname: McCarthy
authors.affiliation: The Jenner Institute Laboratories, Old Road Campus Research Building, University of Oxford, Oxford, OX3 7DQ, UK. Electronic address: simon.draper@ndm.ox.ac.uk.
authors.forename: Simon J
authors.initials: SJ
authors.lastname: Draper
mesh_terms: D000818:Animals; D054884:Host-Pathogen Interactions / Q000276:immunology / Q000502:physiology*; D006801:Humans; D016778:Malaria, Falciparum / Q000517:prevention & control; D016780:Malaria, Vivax / Q000503:physiopathology / Q000517:prevention & control*; D008954:Models, Biological; D010963:Plasmodium falciparum / Q000502:physiology; D010966:Plasmodium vivax / Q000502:physiology
keywords: CHMI; IBSM; malaria; vivax