title: High expression of heat shock protein 10 correlates negatively with estrogen/progesterone receptor status and predicts poor prognosis in invasive ductal breast carcinoma.
abstract: Heat shock proteins (HSPs) usually are associated with stress response and tolerance. HSP10 is a co-chaperone for HSP60, which is involved in the mitochondrial protein-folding machinery. To the best of our knowledge, the expression of HSP10 in invasive ductal breast carcinoma (IDBC) has never been reported. In the present study, HSP10 expression in 242 cases of IDBC and 46 cases of noncancerous breast tissues was detected by immunohistochemistry staining. High expression was significantly more common in IDBC than in noncancerous breast tissues (P<.001). Also, high expression was significantly more common in poorly differentiated than in well- and moderately differentiated IDBC (P=.023). Furthermore, high expression correlated negatively with estrogen receptor and progesterone receptor expression (P=.031 and P=.042, respectively). The most interesting result of the study was that high expression of HSP10 was significantly associated with shorter overall survival by both univariate and multivariate analyses (P=.013 and P=.036, respectively). In conclusion, we report for the first time that high expression of HSP10 is negatively associated with estrogen receptor/progesterone receptor status and might be a novel independent biomarker for poor prognosis in IDBC.
authors.affiliation: Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
authors.forename: Shuzhou
authors.initials: S
authors.lastname: Chu
authors.affiliation: Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
authors.forename: Qiuyuan
authors.initials: Q
authors.lastname: Wen
authors.affiliation: Department of Oncology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
authors.forename: Zhenzhen
authors.initials: Z
authors.lastname: Qing
authors.affiliation: Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
authors.forename: Jiadi
authors.initials: J
authors.lastname: Luo
authors.affiliation: Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
authors.forename: Weiyuan
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
authors.forename: Lingjiao
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Feng
authors.affiliation: Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
authors.forename: Lina
authors.initials: L
authors.lastname: Xu
authors.affiliation: Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
authors.forename: Hongjing
authors.initials: H
authors.lastname: Zang
authors.affiliation: Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China. Electronic address: fansongqing2003@hotmail.com.
authors.forename: Songqing
authors.initials: S
authors.lastname: Fan
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D001706:Biopsy; D001943:Breast Neoplasms / Q000737:chemistry* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D018270:Carcinoma, Ductal, Breast / Q000737:chemistry* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D002454:Cell Differentiation; D018835:Chaperonin 10 / Q000032:analysis*; D016009:Chi-Square Distribution; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D016016:Proportional Hazards Models; D011960:Receptors, Estrogen / Q000032:analysis*; D011980:Receptors, Progesterone / Q000032:analysis*; D012307:Risk Factors; D013997:Time Factors; D015854:Up-Regulation
chemical_list: D014408:Biomarkers, Tumor; D018835:Chaperonin 10; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone
keywords: Biomarkers; Heat shock protein 10; Heat shock proteins; Invasive ductal breast carcinoma; Prognosis