title: Retrospective study of unplanned hospital admission for metastatic cancer patients visiting the emergency department.
abstract: The purpose of the study was to identify factors that predict unplanned admission for metastatic cancer patients visiting the emergency department (ED).
  
  
  
  Patients visiting the ED of a general hospital from April 2012 to March 2013 were investigated retrospectively. Data including demographics, vital signs, and laboratory measurements were collected from a chart review for each patient. Factors related to emergency admission were identified by univariate and multivariate analyses.
  
  
  
  A total of 15,716 individuals visiting the ED during the study period included 1244 (7.9%) patients with cancer. Among the 491 cancer patients with metastasis, univariate analysis revealed that emergency admission was significantly associated with an age of ≥76 years; an altered mental status; fever (≥38 °C); a blood oxygen saturation of <90%; a white blood cell (WBC) count of ≤2000 or ≥10,000/μL; hypoalbuminemia (≤2.5 g/dL); and elevated levels of aspartate aminotransferase (≥100 IU/L), blood urea nitrogen (≥25 mg/dL), and C-reactive protein (CRP, ≥10 mg/dL). Multivariate analysis identified age, an altered mental status, hypoxemia, an abnormal WBC count, and elevated CRP as putative independent predictive factors for emergency admission. The number of these five factors present was also correlated with 30-day mortality (c-statistic = 0.72).
  
  
  
  Age, unconsciousness, hypoxemia, an abnormal WBC count, and elevated CRP were found to be associated with emergency admission and 30-day mortality for metastatic cancer patients. Prospective validation of a predictive scoring system based on these findings is warranted.
authors.affiliation: Department of Medical Oncology, Kishiwada Municipal Hospital, Kishiwada, Osaka, Japan.|Department of Respiratory Medicine, Kurashiki Central Hospital, Kurashiki, Okayama, Japan.
authors.forename: Tae
authors.initials: T
authors.lastname: Tanaka
authors.affiliation: Department of Biostatistics, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan.
authors.forename: Masataka
authors.initials: M
authors.lastname: Taguri
authors.affiliation: Department of Medical Oncology, Kishiwada Municipal Hospital, Kishiwada, Osaka, Japan.
authors.forename: Soichi
authors.initials: S
authors.lastname: Fumita
authors.affiliation: Department of Medical Oncology, Kishiwada Municipal Hospital, Kishiwada, Osaka, Japan.
authors.forename: Kunio
authors.initials: K
authors.lastname: Okamoto
authors.affiliation: Department of Emergency Medicine, Kishiwada Municipal Hospital, Kishiwada, Osaka, Japan.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Matsuo
authors.affiliation: Department of Medical Oncology, Kishiwada Municipal Hospital, Kishiwada, Osaka, Japan. hayashi_h@dotd.med.kindai.ac.jp.|Department of Medical Oncology, Kindai University Faculty of Medicine, 377-2 Ohno-higashi, Osaka-Sayama, Osaka, 589-8511, Japan. hayashi_h@dotd.med.kindai.ac.jp.
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Hayashi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000378:metabolism; D004636:Emergency Service, Hospital / Q000706:statistics & numerical data*; D005260:Female; D005334:Fever / Q000453:epidemiology; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D034141:Hypoalbuminemia / Q000453:epidemiology; D007564:Japan / Q000453:epidemiology; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000097:blood / Q000453:epidemiology* / Q000473:pathology / Q000628:therapy*; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D002097:C-Reactive Protein
keywords: 30-day mortality; Emergency department; Metastatic cancer; Predictive score; Unplanned admission