title: A One-pot Condensation for Synthesis 2-methyl-4-phenylpyrano[3, 2-c] chromen-5(4H)-one and Synthesis of Warfarin by Ionic Liquid Catalysis.
abstract: The anticoagulant racemic warfarin is synthesized by the Michael addition of 4-hydroxycoumarin with benzalacetone in the present of equimolar amounts of imidazolium based ionic liquids [bmim] BF4and [bmim] Br and other reaction solvents such as H2O, pyridine and ammonia in five different tests. Also synthesis of a derivative of warfarin (2-methyl-4-phenyl pyrano [3, 2-c] chromen-5(4H)-one) under solvent-free condition is reported. In this paper, we show the potential that ionic liquid have for the development of green methods for the formation of the C-C bond by reaction condensations without catalysts and organic solvents. A،green method,according to the well-known principles, must reduce or eliminate the use or generation of unsafe substances. The work-up procedures were fairly simple and the products don›t require further purification.
authors.affiliation: Department of Chemistry, Payame-Noor University, P. O. Box 19395-3697, Tehran, Iran.
authors.forename: Aazam
authors.initials: A
authors.lastname: Monfared
authors.affiliation: Department of Chemistry, Payame-Noor University, P. O. Box 19395-3697, Tehran, Iran.
authors.forename: Zohreh
authors.initials: Z
authors.lastname: Esmaeeli
keywords: Ionic liquid; Michael addition; close-ring; warfarin