title: Musical Electroacupuncture May Be a Better Choice than Electroacupuncture in a Mouse Model of Alzheimer's Disease.
abstract: Objectives. To compare musical electroacupuncture and electroacupuncture in a mouse model of Alzheimer's disease.Methods. In this study, 7.5-month-old male senescence-accelerated mouse prone 8 (SAMP8) mice were used as an Alzheimer's disease animal model. In the normal control paradigm, 7.5-month-old male SAMR1 mice were used as the blank control group (N group). After 15 days of treatment, using Morris water maze test, micro-PET, and immunohistochemistry, the differences among the musical electroacupuncture (MEA), electroacupuncture (EA), Alzheimer's disease (AD), and normal (N) groups were assessed.Results. The Morris water maze test, micro-PET, and immunohistochemistry revealed that MEA and EA therapies could improve spatial learning and memory ability, glucose metabolism level in the brain, and Aβamyloid content in the frontal lobe, compared with the AD group (P< 0.05). Moreover, MEA therapy performed better than EA treatment in decreasing amyloid-beta levels in the frontal lobe of mice with AD.Conclusion. MEA therapy may be superior to EA in treating Alzheimer's disease as demonstrated in SAMP8 mice.
authors.affiliation: Beijing University of Chinese Medicine, Beijing 100029, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Jiang
authors.affiliation: Community Health Service Center of Dongcheng District, Beijing 100010, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
authors.affiliation: Third Affiliated Hospital of Beijing University of Chinese Medicine, Beijing 100029, China.
authors.forename: Suhua
authors.identifier: 0000-0002-7641-5216
authors.initials: S
authors.lastname: Shi
authors.affiliation: Beijing University of Chinese Medicine, Beijing 100029, China.
authors.forename: Zhigang
authors.identifier: 0000-0003-0378-3496
authors.initials: Z
authors.lastname: Li
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism* / Q000628:therapy*; D016229:Amyloid beta-Peptides / Q000378:metabolism; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D000818:Animals; D002755:Choice Behavior / Q000502:physiology; D004195:Disease Models, Animal; D015671:Electroacupuncture / Q000379:methods; D006624:Hippocampus / Q000378:metabolism*; D006801:Humans; D008568:Memory / Q000502:physiology*; D051379:Mice; D009146:Music
chemical_list: D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor