title: The Influence of Lithium and/or Selenium Treatment on Homeostasis of Chosen Bioelements in Rats.
abstract: Lithium is widely used in medicine and the therapy is often long term. Apart from beneficial effects, its application can cause diverse side effects. The current study was performed with the aim of the evaluation of the effect of lithium and/or selenium administration on magnesium, calcium and silicon levels in rats. The study was performed on rats divided into four groups (six animals each): control-received saline, Li-received Li2CO3(2.7 mg Li/kg b.w.), Se-received Na2SeO3·H2O (0.5 mg Se/kg b.w.), and Li+Se-received simultaneously Li2CO3and Na2SeO3·H2O (2.7 and 0.5 mg Se/kg b.w.). The administration was performed in form of water solutions by a stomach tube once a day for 6 weeks. In the organs (liver, kidney, brain, spleen, heart, lung and femoral muscle), the concentrations of magnesium, calcium and silicon were determined. Lithium significantly increased Ca in the kidney, brain and spleen. Coadministration of selenium reversed this effect. No changes of magnesium in organs were observed. Silicon was affected only in spleen-an increase vs. control was observed in all studied groups. The beneficial influence of coadministration of selenium in case of calcium lets us suggest that an issue of its possible use as an adjuvant alleviating side effects in lithium-treated subjects is worth being continued.
authors.affiliation: Chair and Department of Medical Chemistry, Medical University of Lublin, Chodźki 4a, 20-093, Lublin, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Kiełczykowska
authors.affiliation: Chair and Department of Medical Chemistry, Medical University of Lublin, Chodźki 4a, 20-093, Lublin, Poland.
authors.forename: Irena
authors.initials: I
authors.lastname: Musik
authors.affiliation: Chair and Department of Medical Chemistry, Medical University of Lublin, Chodźki 4a, 20-093, Lublin, Poland.
authors.forename: Jacek
authors.initials: J
authors.lastname: Kurzepa
authors.affiliation: Chair and Department of Medical Chemistry, Medical University of Lublin, Chodźki 4a, 20-093, Lublin, Poland.
authors.forename: Renata
authors.initials: R
authors.lastname: Żelazowska
authors.affiliation: Chair and Department of Medical Chemistry, Medical University of Lublin, Chodźki 4a, 20-093, Lublin, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Lewandowska
authors.affiliation: Traumatic-Orthopaedic and Spine Surgery Ward of Independent Public Health Care Centre in Puławy, Józefa Bema 1, 24-100, Puławy, Poland.
authors.forename: Marek
authors.initials: M
authors.lastname: Paździor
authors.affiliation: Chair and Department of Medical Chemistry, Medical University of Lublin, Chodźki 4a, 20-093, Lublin, Poland. joanna.kocot@umlub.pl.
authors.forename: Joanna
authors.initials: J
authors.lastname: Kocot
mesh_terms: D000818:Animals; D002118:Calcium / Q000097:blood*; D008094:Lithium / Q000494:pharmacology; D016651:Lithium Carbonate / Q000494:pharmacology*; D008274:Magnesium / Q000097:blood*; D008297:Male; D009928:Organ Specificity / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012643:Selenium / Q000494:pharmacology; D012825:Silicon / Q000097:blood*; D018038:Sodium Selenite / Q000494:pharmacology*
chemical_list: D016651:Lithium Carbonate; D008094:Lithium; D012643:Selenium; D018038:Sodium Selenite; D008274:Magnesium; D002118:Calcium; D012825:Silicon
keywords: Calcium; Lithium; Magnesium; Male rats; Selenium; Silicon