title: αvβ3-Isoform specific erbium complexes highly specific for bladder cancer imaging and photodynamic therapy.
abstract: We have synthesized a bifunctional erbium-porphyrin tumor imaging and PDT agent (Er-R3) that is capable of killing bladder cancer cells via its selective binding to the integrin αvβ3isoform overexpressed on the cell membrane.
authors.affiliation: Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China. wkwong@hkbu.edu.hk klwong@hkbu.edu.hk.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University, Hung Hum, Hong Kong SAR, China.
authors.forename: Chi-Fai
authors.initials: CF
authors.lastname: Chan
authors.affiliation: Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China. wkwong@hkbu.edu.hk klwong@hkbu.edu.hk.
authors.forename: Daniel W J
authors.initials: DW
authors.lastname: Kwong
authors.affiliation: Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University, Hung Hum, Hong Kong SAR, China.
authors.forename: Ga-Lai
authors.initials: GL
authors.lastname: Law
authors.affiliation: Department of Chemistry, Durham University, Durham, DH1 3LE, UK.
authors.forename: Steven
authors.initials: S
authors.lastname: Cobb
authors.affiliation: Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China. wkwong@hkbu.edu.hk klwong@hkbu.edu.hk.
authors.forename: Wai-Kwok
authors.initials: WK
authors.lastname: Wong
authors.affiliation: Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China. wkwong@hkbu.edu.hk klwong@hkbu.edu.hk.
authors.forename: Ka-Leung
authors.identifier: 0000-0002-3750-5980
authors.initials: KL
authors.lastname: Wong
mesh_terms: D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D004871:Erbium / Q000737:chemistry / Q000378:metabolism* / Q000627:therapeutic use*; D006801:Humans; D039302:Integrin alphaVbeta3 / Q000235:genetics / Q000378:metabolism*; D008665:Metalloporphyrins / Q000737:chemistry / Q000378:metabolism* / Q000627:therapeutic use*; D057054:Molecular Imaging; D010778:Photochemotherapy; D001749:Urinary Bladder Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000473:pathology
chemical_list: D039302:Integrin alphaVbeta3; D008665:Metalloporphyrins; D004871:Erbium