title: New insights into the antiangiogenic and proangiogenic properties of dietary polyphenols.
abstract: Polyphenols can be found in natural products of plant origin, including vegetables, fruits, and beverages. A large number of these plant origin compounds are an integral part of the human diet and in the past decade evidence has shown their beneficial properties in human health, by acting in several cell signaling pathways. Among other beneficial effects, polyphenols have been associated with angiogenesis. Increasing evidence highlighting the ability of dietary polyphenols to influence angiogenesis by interfering with multiple signaling pathways is debated. Particular emphasis is given to the mechanisms that ultimately may induce the formation of capillary-like structures (by increasing endothelial cell proliferation, migration, and invasion) or, conversely, may inhibit the steps of angiogenesis leading to the inhibition/regress of vascular development. Dietary polyphenols can, therefore, be viewed as promising nutraceuticals but important aspects have still to be further investigated, to deep knowledge concerning their concentration-mediated effects, effect of specific polyphenols, and respective metabolites, to ensure their appropriate and effective usefulness as proangiogenic or antiangiogenic nutraceuticals.
authors.affiliation: LAQV/REQUIMTE-Departamento de Ciências do Medicamento, Laboratório de Farmacologia, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal.
authors.forename: Carmen
authors.initials: C
authors.lastname: Diniz
authors.affiliation: Department of Human Nutrition and Hygiene, Poznan University of Life Sciences, Poznan, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Suliburska
authors.affiliation: LAQV/REQUIMTE-Departamento de Ciências Químicas, Laboratório de Bromatologia e Hidrologia, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal.
authors.forename: Isabel M P L V O
authors.initials: IMPLVO
authors.lastname: Ferreira
mesh_terms: D043925:Angiogenesis Inducing Agents / Q000494:pharmacology*; D020533:Angiogenesis Inhibitors / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D004032:Diet; D019587:Dietary Supplements; D042783:Endothelial Cells / Q000187:drug effects / Q000378:metabolism; D005638:Fruit / Q000737:chemistry; D006801:Humans; D059808:Polyphenols / Q000494:pharmacology*; D015398:Signal Transduction; D014675:Vegetables / Q000737:chemistry
chemical_list: D043925:Angiogenesis Inducing Agents; D020533:Angiogenesis Inhibitors; D059808:Polyphenols
keywords: Angiogenesis; Anti-angiogenic; Dietary polyphenols; Proangiogenic; Structure-activity relationships