title: The Association between GSTM1, GSTT1 Genetic Variants and Gastric Carcinoma Susceptibility in Chinese: A Systematic Review Article.
abstract: BACKGROUND
  Glutathione S-transferases (GSTs) have been investigated as potential carcinoma susceptible genes. However, the relationship between GSTs (GSTM1,GSTT1) variants and gastric carcinoma (GC) risk has been controversial in Chinese population.
  
  
  METHODS
  A comprehensive literature search strategy (PubMed, Chinese Biomedical Database, Chinese National Knowledge Infrastructure, Wan fang Database, etc.) was launched. Crude odds ratios (ORs) and confidence intervals (95% CI) were applied to estimate the strength of the association.
  
  
  RESULTS
  Significant associations between GSTs genetic polymorphisms and GC were evidenced under random-effects model (ORGSTM1=1.56, 95% CI: 1.39 to 1.76, I2=50.7%,P<0.0001; ORGSTT1=1.24, 95% CI: 1.10 to 1.39, I2=43.6%,P=0.014; ORGSTM1-GSTT1=1.51, 95% CI: 1.26 to 1.81, I2=59.7%,P=0.004). The pooled ORs were not qualitatively changed when any single study was omitted by sensitivity analysis.
  
  
  CONCLUSIONS
  Our results indicated an increased GC risk in Chinese population withGSTM1andGSTT1null genotype andGSTM1-GSTT1dual null genotype. Further multi-center studies are needed to investigate the gene-gene and gene-environment interactions on the susceptibility of GC.
authors.affiliation: Dept. of Science and Technology, Kunming Medical University, Kunming, China.
authors.forename: Dingyun
authors.initials: D
authors.lastname: You
authors.affiliation: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, China.
authors.forename: Nanjia
authors.initials: N
authors.lastname: Lu
authors.affiliation: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, China.
authors.forename: Donghui
authors.initials: D
authors.lastname: Duan
authors.affiliation: Institute of Non-Communicable Disease Control and Prevention, Ningbo Municipal Center for Disease Control and Prevention, Ningbo, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.affiliation: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, China.
authors.forename: Wenhua
authors.initials: W
authors.lastname: Xing
keywords: GSTs; Gastric carcinoma; Glutathione S-transferase; Meta-analysis