title: Induced pluripotent stem cells: An unlimited source of organs for transplantation.
abstract: Organ production outside the human body could address the shortage of organs for transplantation. However, in vitro organ production is still a faraway perspective, particularly because of the difficulty in establishing an effective vascularization. A new emerging technology proposes to use carrier animals for the development of human organs. In this approach, induced pluripotent stem cells (iPSC) are injected in animal embryos to produce chimeric animals that contain autologous human organs.
authors.affiliation: CHU de Montpellier, Institute for Regenerative Medicine and Biotherapy, hôpital Saint-Éloi, 80, avenue Augustin-Fliche, 34000 Montpellier cedex 5, France; Inserm, U1183, 34000 Montpellier, France; Université de Montpellier, UFR de médecine, 34000 Montpellier, France; CHU de Montpellier, Unit for Cellular Therapy, Hospital Saint-Éloi, 34000 Montpellier, France. Electronic address: john.devos@inserm.fr.
authors.forename: J
authors.initials: J
authors.lastname: De Vos
authors.affiliation: CHU de Montpellier, Institute for Regenerative Medicine and Biotherapy, hôpital Saint-Éloi, 80, avenue Augustin-Fliche, 34000 Montpellier cedex 5, France; Inserm, U1183, 34000 Montpellier, France; Université de Montpellier, UFR de médecine, 34000 Montpellier, France. Electronic address: said.assou@inserm.fr.
authors.forename: S
authors.initials: S
authors.lastname: Assou
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002678:Chimera; D033041:Embryo Research; D004622:Embryo, Mammalian; D006801:Humans; D057026:Induced Pluripotent Stem Cells; D016377:Organ Transplantation / Q000379:methods; D033581:Stem Cell Transplantation / Q000379:methods