title: [Regulatory roles of non-coding RNAs in cardiomyocyte differentiation].
abstract: Heart is the first organ to function during mammalian embryogenesis. The differentiation of embryonic stem cells (ESCs) into cardiomyocyte is complex and dynamic, which involves 4 differentiation stages including ESCs, mesoderm, cardiac precursor, and terminal cardiomyocytes. Abnormal expression of certain genes can lead to congenital heart diseases during cardiomyocyte differentiation. Epigenetic regulation plays a crucial role on the switch of gene activation and deactivation during cardiomyocyte differentiation. Non-coding RNA, particularly microRNA and long non-coding RNA, may significantly influence gene expression. Exploring the regulatory roles of non-coding RNA in cardiomyocyte differentiation may contribute to the understanding of the functions of myocardial cells and mechanism of congenital heart diseases.
authors.affiliation: Key Laboratory of Arrhythmias, Ministry of Education, Tongji University School of Medicine, Shanghai 200092, China. lilirz@tongji.edu.cn.
authors.forename: Yumei
authors.initials: Y
authors.lastname: Wang
authors.forename: Luying
authors.initials: L
authors.lastname: Peng
authors.forename: Li
authors.initials: L
authors.lastname: Li
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000235:genetics*; D004622:Embryo, Mammalian / Q000502:physiology; D053595:Embryonic Stem Cells / Q000502:physiology; D044127:Epigenesis, Genetic / Q000235:genetics; D006801:Humans; D032383:Myocytes, Cardiac / Q000502:physiology*; D062085:RNA, Long Noncoding / Q000235:genetics*
chemical_list: D062085:RNA, Long Noncoding