title: A Facile and Versatile Method to Endow Biomaterial Devices with Zwitterionic Surface Coatings.
abstract: The surface modification of implantable biomaterials with zwitterionic phosphorylcholine polymer is demonstrated through mussel-mimetic catecholamine polymer thin films. Using this method, the surfaces of alginate hydrogel microspheres and polystyrene microbeads, a model material known to produce robust foreign body responses and fibrosis, are successfully modified to reduce the tissue reaction by reducing the fibrosis in immunocompetent C57BL/6J mice.
authors.affiliation: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.|Department of Anesthesiology, Boston Children's Hospital, Boston, MA, 02115, USA.
authors.forename: Volkan
authors.initials: V
authors.lastname: Yesilyurt
authors.affiliation: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.|Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
authors.forename: Omid
authors.initials: O
authors.lastname: Veiseh
authors.affiliation: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.|Department of Anesthesiology, Boston Children's Hospital, Boston, MA, 02115, USA.
authors.forename: Joshua C
authors.initials: JC
authors.lastname: Doloff
authors.affiliation: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.|Department of Anesthesiology, Boston Children's Hospital, Boston, MA, 02115, USA.
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.affiliation: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.|Department of Anesthesiology, Boston Children's Hospital, Boston, MA, 02115, USA.
authors.forename: Suman
authors.initials: S
authors.lastname: Bose
authors.affiliation: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
authors.forename: Xi
authors.initials: X
authors.lastname: Xie
authors.affiliation: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.|Department of Anesthesiology, Boston Children's Hospital, Boston, MA, 02115, USA.
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Bader
authors.affiliation: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.|Department of Anesthesiology, Boston Children's Hospital, Boston, MA, 02115, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Chen
authors.affiliation: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.|Department of Anesthesiology, Boston Children's Hospital, Boston, MA, 02115, USA.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Webber
authors.affiliation: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.|Department of Anesthesiology, Boston Children's Hospital, Boston, MA, 02115, USA.
authors.forename: Arturo J
authors.initials: AJ
authors.lastname: Vegas
authors.affiliation: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.|Department of Anesthesiology, Boston Children's Hospital, Boston, MA, 02115, USA.|Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.|Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Langer
authors.affiliation: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.|Department of Anesthesiology, Boston Children's Hospital, Boston, MA, 02115, USA.|Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.|Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
authors.forename: Daniel G
authors.initials: DG
authors.lastname: Anderson
mesh_terms: D000818:Animals; D002395:Catecholamines / Q000737:chemistry / Q000494:pharmacology; D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000494:pharmacology; D004343:Drug Implants / Q000737:chemistry / Q000494:pharmacology; D005355:Fibrosis; D005549:Foreign-Body Reaction / Q000517:prevention & control; D008567:Membranes, Artificial; D051379:Mice; D010767:Phosphorylcholine / Q000737:chemistry / Q000494:pharmacology
chemical_list: D002395:Catecholamines; D020099:Coated Materials, Biocompatible; D004343:Drug Implants; D008567:Membranes, Artificial; D010767:Phosphorylcholine
keywords: alginate; dopamine; fibrosis; foreign body response; zwitterionic polymers