title: Tissue resident memory T cells and viral immunity.
abstract: Tissue resident memory T cells (TRM) constitute a recently identified T cell lineage that is responsible for frontline defense against viral infections. In contrast to central and effector memory T cells, which constitutively recirculate between tissues and blood, TRMreside permanently within tissues. As the main surveyors of non-lymphoid tissues, TRMare positioned to rapidly respond upon reinfection at barrier sites. During a viral reinfection, TRMtrigger the local tissue environment to activate and recruit immune cells and establish an antiviral state. Consistent with this function, there is empirical evidence that TRMaccelerate control in the event of reinfection or possible reactivation of latent infections in solid organs and barrier tissues. Here we review recent literature highlighting the protective functions of TRMin multiple viral challenge models and contextualize the implications of these findings for vaccine development.
authors.affiliation: Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN 55455, United States; Center for Immunology, University of Minnesota, Minneapolis, MN 55455, United States.
authors.forename: Pamela C
authors.initials: PC
authors.lastname: Rosato
authors.affiliation: Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN 55455, United States; Center for Immunology, University of Minnesota, Minneapolis, MN 55455, United States.
authors.forename: Lalit K
authors.initials: LK
authors.lastname: Beura
authors.affiliation: Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN 55455, United States; Center for Immunology, University of Minnesota, Minneapolis, MN 55455, United States. Electronic address: masopust@umn.edu.
authors.forename: David
authors.initials: D
authors.lastname: Masopust
mesh_terms: D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D006801:Humans; D007156:Immunologic Memory; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D014777:Virus Diseases / Q000276:immunology*