title: Visible-Light-Induced Direct Difluoroalkylation of Uracils, Pyridinones, and Coumarins.
abstract: An efficient and general method for the synthesis of difluoroalkylated uracils, pyridinones, and coumarins through visible-light-induced reaction with commercial materials is developed. The strategy proceeds with high efficiency under mild reaction conditions and shows excellent functional group compatibility, even toward bromide and hydroxyl group, thus demonstrates high potent application in a late-stage fluoroalkylation. Moreover, the difluoroalkylated products can be further transformed to a diverse variety of difluoroalkylated heterocycles, including molecules of potential biological activity.
authors.affiliation: School of Pharmacy, Zunyi Medical University , No. 6 West Xuefu Road, Zunyi, Guizhou 563003, China.
authors.forename: Chun-Yang
authors.identifier: 0000-0002-0599-7335
authors.initials: CY
authors.lastname: He
authors.affiliation: School of Pharmacy, Zunyi Medical University , No. 6 West Xuefu Road, Zunyi, Guizhou 563003, China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Kong
authors.affiliation: School of Pharmacy, Zunyi Medical University , No. 6 West Xuefu Road, Zunyi, Guizhou 563003, China.
authors.forename: Xuefei
authors.initials: X
authors.lastname: Li
authors.affiliation: School of Pharmacy, Zunyi Medical University , No. 6 West Xuefu Road, Zunyi, Guizhou 563003, China.
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Li
authors.affiliation: School of Pharmacy, Zunyi Medical University , No. 6 West Xuefu Road, Zunyi, Guizhou 563003, China.
authors.forename: Qiuli
authors.initials: Q
authors.lastname: Yao
authors.affiliation: School of Pharmacy, Zunyi Medical University , No. 6 West Xuefu Road, Zunyi, Guizhou 563003, China.
authors.forename: Fu-Ming
authors.initials: FM
authors.lastname: Yuan
mesh_terms: D000478:Alkylation / Q000528:radiation effects; D003374:Coumarins / Q000737:chemistry / Q000378:metabolism*; D005461:Fluorine / Q000737:chemistry*; D008027:Light; D015394:Molecular Structure; D011728:Pyridones / Q000737:chemistry / Q000378:metabolism*; D014498:Uracil / Q000737:chemistry / Q000378:metabolism*
chemical_list: D003374:Coumarins; D011728:Pyridones; D005461:Fluorine; D014498:Uracil