title: Latency to vaginal mesh exposure with mesh placed abdominally versus vaginally in pelvic floor surgery: A retrospective comparative study.
abstract: The primary aim was to compare the difference in time to mesh exposure between mesh placed abdominally versus vaginally. This is a retrospective comparative study of patients presented with vaginal mesh exposure between January 2001 and July 2012. This study compares patients who had undergone vaginally placed mesh procedures to those who had had abdominally placed mesh. Kaplan-Meier survival analysis was used to measure the time to mesh exposure. There were 68 patients with mesh exposure in our cohort. Thirty eight patients had undergone vaginal placement of mesh and 30 patients had abdominal mesh. There was a statistically significant difference in time to mesh exposure between abdominal and vaginal meshes (p≤.0001). Mean time to vaginal mesh exposure with abdominal mesh was 59.8 months (95%CI 46.2-73.3) compared to 23 months (95%CI 15.9-30.2) for vaginal mesh. When controlling for age, BMI and surgeon at index surgery, the Hazard Ratio for mesh exposure in our Cox Regression model was 0.53 (95%CI 0.39-0.71) (p ≤.0001). The mean time to vaginal mesh exposure after abdominal mesh was longer compared to the time to exposure with vaginally placed mesh (60 versus 23 months, p ≤.0001). These results support the evolving evidence that mesh exposures can occur many years distant from the procedure and warrant some level of surveillance or provision of warning signs by the providers who perform procedures with mesh.
authors.affiliation: a Department of Obstetrics & Gynecology, Oregon Health & Science University , Portland , OR , USA.|b Department of Obstetrics & Gynecology, St John Hospital and Medical Center , Detroit , MI , USA.
authors.forename: Muhammad F
authors.initials: MF
authors.lastname: Aslam
authors.affiliation: a Department of Obstetrics & Gynecology, Oregon Health & Science University , Portland , OR , USA.
authors.forename: Mary Anna
authors.initials: MA
authors.lastname: Denman
authors.affiliation: a Department of Obstetrics & Gynecology, Oregon Health & Science University , Portland , OR , USA.
authors.forename: Sharon R
authors.initials: SR
authors.lastname: Edwards
authors.affiliation: a Department of Obstetrics & Gynecology, Oregon Health & Science University , Portland , OR , USA.
authors.forename: William T
authors.initials: WT
authors.lastname: Gregory
mesh_terms: D000005:Abdomen / Q000601:surgery; D000368:Aged; D005260:Female; D006801:Humans; D008875:Middle Aged; D059952:Pelvic Floor Disorders / Q000601:surgery*; D056887:Pelvic Organ Prolapse / Q000601:surgery*; D012189:Retrospective Studies; D053825:Suburethral Slings / Q000009:adverse effects; D013526:Surgical Mesh / Q000009:adverse effects*; D014549:Urinary Incontinence / Q000601:surgery; D014621:Vagina / Q000601:surgery
keywords: Mesh erosion; abdominal mesh; mesh exposure; time to mesh exposure; vaginal mesh