title: PSMA Expression in Tumor Neovasculature Endothelial Cells of Follicular Thyroid Adenoma as Identified by Molecular Imaging Using 68Ga-PSMA Ligand PET/CT.
abstract: The prostate-specific membrane antigen (PSMA) is expressed by both prostate cancer and other neoplasms. We report the case of a 65-year-old man with castration-resistant metastatic prostate cancer who underwent Ga-PSMA ligand PET/CT for restaging of disease. Ga-PSMA ligand accumulation was noted in a thyroid lesion, suspicious for thyroid malignancy on complementary ultrasound. Subsequent resection and histopathological analysis showed follicular thyroid adenoma with PSMA expression in tumor neovasculature endothelial cells, but not in thyroid epithelial cells. It is important to be aware that both malignant and benign thyroid neoplasms may show PSMA expression to avoid misinterpretation.
authors.affiliation: From the *Department of Nuclear Medicine, and †Institute of Pathology, Hannover Medical School, Hannover; and ‡Department of Anatomy and Experimental Morphology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
authors.forename: Thorsten
authors.initials: T
authors.lastname: Derlin
authors.forename: Hans-Heinrich
authors.initials: HH
authors.lastname: Kreipe
authors.forename: Udo
authors.initials: U
authors.lastname: Schumacher
authors.forename: Bisharah
authors.initials: B
authors.lastname: Soudah
mesh_terms: D000236:Adenoma / Q000000981:diagnostic imaging*; D000368:Aged; D000954:Antigens, Surface / Q000235:genetics / Q000378:metabolism; D004492:Edetic Acid / Q000031:analogs & derivatives; D004730:Endothelium, Vascular / Q000000981:diagnostic imaging / Q000378:metabolism; D005709:Gallium Isotopes; D005710:Gallium Radioisotopes; D043425:Glutamate Carboxypeptidase II / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008297:Male; D009389:Neovascularization, Pathologic / Q000000981:diagnostic imaging*; D009842:Oligopeptides; D009942:Organometallic Compounds; D000072078:Positron Emission Tomography Computed Tomography; D019275:Radiopharmaceuticals; D013961:Thyroid Gland / Q000098:blood supply / Q000000981:diagnostic imaging / Q000473:pathology; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology
chemical_list: D000954:Antigens, Surface; D005709:Gallium Isotopes; D005710:Gallium Radioisotopes; D009842:Oligopeptides; D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; C000718244:gallium 68 PSMA-11; D004492:Edetic Acid; C473848:FOLH1 protein, human; D043425:Glutamate Carboxypeptidase II