title: [Histopathological analysis of oral lichen planus with malignant transformation].
abstract: Objective:To estimate the histological features of oral lichen planus (OLP) which underwent malignant transformation and discuss the current problems in OLP pathological diagnosis.Methods:Using the modified WHO OLP criteria (2003), reevaluated the pathological changes of cases diagnosed initially as OLP and transformed into squamous cell carcinomas indicated by subsequent biopsies.Results:Among 3 721 cases of OLP clinically and pathologically diagnosed during 1984 and 2015, there were 19 cases (0.51%) having underwent malignant transformation. Reevaluation of the initial biopsies revealed that 10 cases did not meet the criteria of OLP, as without characteristic basal cell liquefaction, not exhibiting sufficient band-like lymphocytes infiltration, or presenting with epithelial dysplasia. There were 9 cases of OLP malignant transformation left after the reevaluation.Conclusions:Pathological diagnosis of OLP should fully fit the criteria i.e. basal cell liquefaction, typical band-like lymphocytes infiltration and absence of epithelial dysplasia, which is also a prerequisite for researches in malignant transformation of OLP.
authors.affiliation: Department of Oral Pathology, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Department of Oral Pathology, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.
authors.forename: H Y
authors.initials: HY
authors.lastname: Luo
mesh_terms: D001706:Biopsy; D002294:Carcinoma, Squamous Cell; D002471:Cell Transformation, Neoplastic; D006801:Humans; D017676:Lichen Planus, Oral; D009062:Mouth Neoplasms