title: Palladium-Catalyzed Tandem C-H Functionalization/Cyclization Strategy for the Synthesis of 5-Hydroxybenzofuran Derivatives.
abstract: A palladium-catalyzed benzoquinone C-H functionalization/cyclization strategy with terminal alkynes was employed for the synthesis of some biologically relevant 2,3-disubstituted 5-hydroxybenzofuran derivatives. The benzoquinone acts as a reactant as well as an oxidant. During the process, an additional alkyne functionality can be introduced at the C3 position of the benzofuran. Base, ligand, and external oxidant are not required in this protocol.
authors.affiliation: Department of Chemistry, National Taiwan Normal University , 88, Section 4, Ting-Chow Road, Taipei 116, Taiwan, R.O.C.
authors.forename: Sachin S
authors.initials: SS
authors.lastname: Ichake
authors.affiliation: Department of Chemistry, National Taiwan Normal University , 88, Section 4, Ting-Chow Road, Taipei 116, Taiwan, R.O.C.
authors.forename: Ashok
authors.initials: A
authors.lastname: Konala
authors.affiliation: Department of Chemistry, National Taiwan Normal University , 88, Section 4, Ting-Chow Road, Taipei 116, Taiwan, R.O.C.
authors.forename: Veerababurao
authors.initials: V
authors.lastname: Kavala
authors.affiliation: Department of Chemistry, National Taiwan Normal University , 88, Section 4, Ting-Chow Road, Taipei 116, Taiwan, R.O.C.
authors.forename: Chun-Wei
authors.initials: CW
authors.lastname: Kuo
authors.affiliation: Department of Chemistry, National Taiwan Normal University , 88, Section 4, Ting-Chow Road, Taipei 116, Taiwan, R.O.C.
authors.forename: Ching-Fa
authors.identifier: 0000-0002-8692-5156
authors.initials: CF
authors.lastname: Yao