title: Venlafaxine intoxication in an adolescent presenting with severe lactic acidosis.
abstract: Venlafaxine is a selective serotonin noradrenaline reuptake inhibitor and commonly prescribed antidepressant in adults. Most patients overdosing with venlafaxine develop only mild symptoms. Severe toxicity is reported with the most common symptoms being CNS depression, serotonin toxicity, seizure, or cardiac conduction abnormalities. However, lactic acidosis is an uncommon adverse effect. Here, we present the first case in the literature reporting lactic acidosis due to venlafaxine overuse in an adolescent.
authors.affiliation: Division of Pediatric Gastroenterology, Department of Pediatrics, Ankara University Faculty of Medicine, Ankara, Turkey.
authors.forename: İrem
authors.initials: İ
authors.lastname: Eldem
authors.affiliation: Pediatric Intensive Care Unit, Ankara University Faculty of Medicine, Ankara, Turkey.
authors.forename: Tanıl
authors.initials: T
authors.lastname: Kendirli
authors.affiliation: Pediatric Intensive Care Unit, Ankara University Faculty of Medicine, Ankara, Turkey.
authors.forename: Ebru
authors.initials: E
authors.lastname: Azapağası
authors.affiliation: Division of Pediatric Gastroenterology, Department of Pediatrics, Ankara University Faculty of Medicine, Ankara, Turkey.
authors.forename: Gülşah
authors.initials: G
authors.lastname: Özdemir
authors.affiliation: Division of Pediatric Gastroenterology, Department of Pediatrics, Ankara University Faculty of Medicine, Ankara, Turkey.
authors.forename: Çisem
authors.initials: Ç
authors.lastname: Yıldız
authors.affiliation: Division of Pediatric Gastroenterology, Department of Pediatrics, Ankara University Faculty of Medicine, Ankara, Turkey.
authors.forename: Mehmet Mustafa
authors.initials: MM
authors.lastname: Yılmaz
authors.affiliation: Division of Pediatric Gastroenterology, Department of Pediatrics, Ankara University Faculty of Medicine, Ankara, Turkey.
authors.forename: Özlem
authors.initials: Ö
authors.lastname: Karataşoğlu
authors.affiliation: Division of Pediatric Gastroenterology, Department of Pediatrics, Ankara University Faculty of Medicine, Ankara, Turkey.
authors.forename: Elif
authors.initials: E
authors.lastname: Benderlioğlu
mesh_terms: D000140:Acidosis, Lactic / Q000139:chemically induced* / Q000188:drug therapy; D000293:Adolescent; D062787:Drug Overdose / Q000188:drug therapy; D005260:Female; D006801:Humans; D017367:Selective Serotonin Reuptake Inhibitors / Q000506:poisoning*; D000069470:Venlafaxine Hydrochloride / Q000506:poisoning*
chemical_list: D017367:Selective Serotonin Reuptake Inhibitors; D000069470:Venlafaxine Hydrochloride
keywords: adolescent; lactic acidosis; overdose; venlafaxine