title: Ruthenium-Catalyzed Azide Alkyne Cycloaddition Reaction: Scope, Mechanism, and Applications.
abstract: The ruthenium-catalyzed azide alkyne cycloaddition (RuAAC) affords 1,5-disubstituted 1,2,3-triazoles in one step and complements the more established copper-catalyzed reaction providing the 1,4-isomer. The RuAAC reaction has quickly found its way into the organic chemistry toolbox and found applications in many different areas, such as medicinal chemistry, polymer synthesis, organocatalysis, supramolecular chemistry, and the construction of electronic devices. This Review discusses the mechanism, scope, and applications of the RuAAC reaction, covering the literature from the last 10 years.
authors.affiliation: Cardiovascular and Metabolic Diseases, Innovative Medicines and Early Development Biotech Unit, AstraZeneca , Pepparedsleden 1, SE-43183 Mölndal, Sweden.
authors.forename: Johan R
authors.initials: JR
authors.lastname: Johansson
authors.affiliation: Research Centre for Natural Sciences, Hungarian Academy of Sciences , Magyar tudósok krt. 2, H-1117 Budapest, Hungary.
authors.forename: Tamás
authors.initials: T
authors.lastname: Beke-Somfai
authors.affiliation: Chemistry and Biochemistry, Department of Chemistry and Chemical Engineering, Chalmers University of Technology , SE-41296 Göteborg, Sweden.
authors.forename: Anna
authors.initials: A
authors.lastname: Said Stålsmeden
authors.affiliation: Chemistry and Biochemistry, Department of Chemistry and Chemical Engineering, Chalmers University of Technology , SE-41296 Göteborg, Sweden.
authors.forename: Nina
authors.initials: N
authors.lastname: Kann