title: Xenobiotic Receptor-Mediated Regulation of Intestinal Barrier Function and Innate Immunity.
abstract: The molecular basis for the regulation of the intestinal barrier is a very fertile research area. A growing body of knowledge supports the targeting of various components of intestinal barrier function as means to treat a variety of diseases, including the inflammatory bowel diseases. Herein, we will summarize the current state of knowledge ofkey xenobiotic receptor regulatorsof barrier function, highlighting recent advances, such that the field and its future are succinctly reviewed. We posit that these receptors confer an additional dimension of host-microbe interaction in the gut, by sensing and responding to metabolites released from the symbiotic microbiota, in innate immunity and also in host drug metabolism. The scientific evidence for involvement of the receptors and its molecular basis for the control of barrier function and innate immunity regulation would serve as a rationale towards development of non-toxic probes and ligands as drugs.
authors.affiliation: Departments of Medicine and Genetics, The Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA.
authors.forename: Harmit S
authors.initials: HS
authors.lastname: Ranhotra
authors.affiliation: Departments of Physiology and Pharmacology, University of Calgary, 3330 Hospital Dr. NW, Health Sciences Room 1802, Calgary, Alberta T2N4N1.
authors.forename: Kyle L
authors.initials: KL
authors.lastname: Flannigan
authors.affiliation: Departments of Medicine and Genetics, The Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA.
authors.forename: Martina
authors.initials: M
authors.lastname: Brave
authors.affiliation: Departments of Medicine and Genetics, The Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA.
authors.forename: Subhajit
authors.initials: S
authors.lastname: Mukherjee
authors.affiliation: Departments of Medicine and Genetics, The Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA.
authors.forename: Dana J
authors.initials: DJ
authors.lastname: Lukin
authors.affiliation: Departments of Physiology and Pharmacology, University of Calgary, 3330 Hospital Dr. NW, Health Sciences Room 1802, Calgary, Alberta T2N4N1.
authors.forename: Simon A
authors.initials: SA
authors.lastname: Hirota
authors.affiliation: Departments of Medicine and Genetics, The Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA.
authors.forename: Sridhar
authors.initials: S
authors.lastname: Mani
keywords: Orphan nuclear receptors; barrier function; intestinal innate immunity; microbial metabolites; xenobiotics