title: Clinical efficacy of four interventions in the reduction of dentinal hypersensitivity: A 2-month study.
abstract: OBJECTIVE
  Dentinal hypersensitivity is a relatively common problem experienced in clinical dental practice and is characterized by short, sharp pain in response to stimuli such as tactile, thermal, evaporative, osmotic, or chemical. Several agents and treatment modalities have been used in the treatment of this condition. This study was conducted to compare the efficacy of four commercially available toothpastes in the reduction of dentinal hypersensitivity (DH), based on the hypothesis that calcium sodium phosphosilicate (CSPS) group had a better efficacy of the four.
  
  
  METHODS
  This study design was a prospective, single-blind, randomized, parallel clinical design.
  
  
  METHODS
  A total of 160 cases (93 males and 67 females; aged 20-60 years) were randomly divided into four groups: Group 1 - toothpaste containing 5% potassium nitrate; Group 2 - toothpaste containing 5% CSPS (NovaMin); Group 3 - toothpaste containing 10% strontium chloride; and Group 4 - a herbal formulation. The patients' DH scores for tactile, thermal, and evaporative stimuli were recorded on a visual analog scale at baseline, 2 weeks, 1 month, and 2 months.
  
  
  METHODS
  The data were analyzed with Wilcoxon signed-rank test, Kruskal-Wallis test, and Mann-Whitney U-test (P < 0.05).
  
  
  RESULTS
  The four desensitizing kinds of toothpaste containing different active agents were effective in relieving dentinal hypersensitivity. However, CSPS group showed a better clinical response at the end of 2 months.
  
  
  CONCLUSIONS
  The CSPS group showed a better reduction in the symptoms of DH.
authors.affiliation: Department of Periodontics, GITAM Dental College, Visakhapatnam, Andhra Pradesh, India.
authors.forename: Priyanka
authors.initials: P
authors.lastname: Majji
authors.affiliation: Department of Periodontics, GITAM Dental College, Visakhapatnam, Andhra Pradesh, India.
authors.forename: K Raja Venkatesh
authors.initials: KR
authors.lastname: Murthy
mesh_terms: D000328:Adult; D002130:Calcium Phosphates / Q000627:therapeutic use; D003807:Dentin Sensitivity / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009566:Nitrates / Q000627:therapeutic use; D010147:Pain Measurement; D017680:Potassium Compounds / Q000627:therapeutic use; D011446:Prospective Studies; D017640:Silicates / Q000627:therapeutic use; D016037:Single-Blind Method; D013324:Strontium / Q000627:therapeutic use; D014100:Toothpastes / Q000627:therapeutic use*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D002130:Calcium Phosphates; D009566:Nitrates; D017680:Potassium Compounds; D017640:Silicates; D014100:Toothpastes; C076375:rhenanite; C025700:strontium chloride; C023844:potassium nitrate; D013324:Strontium