title: Circulating miR-181a as a Potential Novel Biomarker for Diagnosis of Acute Myocardial Infarction.
abstract: BACKGROUND
  In this study, we tested the hypothesis that miR-181a levels increase during acute myocardial infarction. We investigated circulating miR-181a as a potential novel biomarker for early diagnosis of acute myocardial infarction (AMI).
  
  
  METHODS
  From June 2014 to June 2016, 120 consecutive eligible patients with AMI (n = 60) or unstable angina (UA; n = 60) and 60 control subjects were enrolled. Plasma miR-181a levels were determined by quantitative reverse transcriptase-polymerase chain reaction.
  
  
  RESULTS
  Circulating miR-181a expression levels detected immediately after admission were higher in the AMI group than in the UA and control groups. Relative miR-181a levels in AMI patients were positively correlated with the concentrations of the creatine kinase-MB fraction and cardiac troponin I. Correlation analysis showed that plasma miR-181a was positively correlated with coronary Gensini score (r = 0.573, P < 0.05) and negatively correlated with left ventricular ejection fraction (r = -0.489, P < 0.05). Receiver operating characteristic curve analyses showed that plasma miR-181a was of significant diagnostic value for AMI (AUC, 0.834; 95% CI, 0.756-0.912, P < 0.05).
  
  
  CONCLUSIONS
  Circulating miR-181a levels in patients with AMI were significantly changed in a time-dependent manner, indicating the value of plasma miR-181a as a novel biomarker for diagnosing AMI.
authors.affiliation: Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.
authors.forename: Jianbing
authors.initials: J
authors.lastname: Zhu
authors.forename: Kang
authors.initials: K
authors.lastname: Yao
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.forename: Junjie
authors.initials: J
authors.lastname: Guo
authors.forename: Hongtao
authors.initials: H
authors.lastname: Shi
authors.forename: Leilei
authors.initials: L
authors.lastname: Ma
authors.forename: Haibo
authors.initials: H
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Gao
authors.forename: Yunzeng
authors.initials: Y
authors.lastname: Zou
authors.forename: Junbo
authors.initials: J
authors.lastname: Ge
mesh_terms: D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000097:blood* / Q000235:genetics; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000175:diagnosis* / Q000235:genetics; D018384:Oxidative Stress; D062645:Percutaneous Coronary Intervention
chemical_list: D015415:Biomarkers; C540193:MIrn181 microRNA, human; D035683:MicroRNAs