title: N,N,N-Trimethyl chitosan: An advanced polymer with myriad of opportunities in nanomedicine.
abstract: N,N,N-trimethyl chitosan (TMC), a quaternized hydrophilic derivative of chitosan (CHT), outperformed the well-known solubility issues raised by CHT. The excellent properties offered by TMC provide it a significant edge for nanoparticle (NP) formation over other nanocarrier materials. Recently, TMC NPs have been applied to various fields like pharmaceutical, biomedical, biomaterials, and biotechnological field. The aim of this review is, therefore, to bring the TMC into the limelight so as to appraise it as an attractive functional polymer for nanomedicine applications which is facing oversight, at present, by regulatory agencies and manufacturers. The versatility of surface-tailoring, the capability of further chemical modifications, and the feasibility of ligand-conjugations in TMC polymer will further assist the scientists for reaching new dimensions in the nano-assembly of novel structures based on TMC.
authors.affiliation: Industrial Pharmacy Laboratory, Department of Pharmaceutics, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra, India.
authors.forename: Abhijeet D
authors.initials: AD
authors.lastname: Kulkarni
authors.affiliation: Division of Computer Aided Drug Design, Department of Pharmaceutical Chemistry, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra, India.
authors.forename: Harun M
authors.initials: HM
authors.lastname: Patel
authors.affiliation: Department of Pharmacognosy, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra, India.
authors.forename: Sanjay J
authors.initials: SJ
authors.lastname: Surana
authors.affiliation: Medicinal Chemistry Laboratory, Department of Pharmaceutical Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, Karnataka, India.
authors.forename: Yogesh H
authors.initials: YH
authors.lastname: Vanjari
authors.affiliation: Department of Pharmaceutical Sciences, RTM Nagpur University, Nagpur, Maharashtra, India.
authors.forename: Veena S
authors.initials: VS
authors.lastname: Belgamwar
authors.affiliation: Industrial Pharmacy Laboratory, Department of Pharmaceutics, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra, India. Electronic address: chandrakantpardeshi11@gmail.com.
authors.forename: Chandrakantsing V
authors.initials: CV
authors.lastname: Pardeshi
mesh_terms: D048271:Chitosan / Q000737:chemistry*; D004337:Drug Carriers; D050997:Nanomedicine; D053758:Nanoparticles; D011108:Polymers
chemical_list: D004337:Drug Carriers; C118071:N-trimethyl chitosan chloride; D011108:Polymers; D048271:Chitosan
keywords: Chitosan; Mucoadhesion; Nanomedicine; Nasal vaccine; Tissue engineering; Trimethyl chitosan