title: The role of bone resorption in the etiopathogenesis of acquired middle ear cholesteatoma.
abstract: Cholesteatoma is a destructive squamous epithelial lesion of the temporal bone which gradually expands and leads to serious complications by destruction of nearby bony structures. Erosion caused by bone resorption of the ossicular chain and bony labyrinth may result in hearing loss, vestibular dysfunction, facial paralysis, labyrinthine fistulae and intracranial complications. The exact underlying cellular and molecular mechanism of bone resorption in acquired cholesteatoma still remains unexplained. Pubmed database and China National Knowledge Infrastructure were screened for articles focusing on bone resorption in acquired cholesteatoma. Osteoclast activation, pressure necrosis, acid lysis, enzyme mediation, inflammatory mediators and several newly discovered biomolecules are outlined as main theories behind bone resorption in acquired cholesteatoma, aiming to facilitate the development of potential therapeutic targets for preventing intracranial and extracranial complications caused by bone resorption in acquired middle ear cholesteatoma.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, The Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
authors.forename: Shumin
authors.initials: S
authors.lastname: Xie
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
authors.forename: Jihao
authors.initials: J
authors.lastname: Ren
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China. lw-007@163.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
mesh_terms: D001862:Bone Resorption / Q000209:etiology / Q000517:prevention & control; D018424:Cholesteatoma, Middle Ear / Q000150:complications / Q000503:physiopathology; D004429:Ear Ossicles / Q000473:pathology; D007758:Ear, Inner / Q000473:pathology; D034381:Hearing Loss / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D013701:Temporal Bone / Q000473:pathology
keywords: Bone resorption; Cholesteatoma; Etiopathogenesis; Osteoclast