title: Intramolecular Acylation of Unactivated Pyridines or Arenes via Multiple C-H Functionalizations: Synthesis of All Four Azafluorenones and Fluorenones.
abstract: An unprecedented intramolecular acylation of unactivated pyridines via multiple C(sp3/sp2)-H functionalizations of a methyl, hydroxymethyl, or aldehyde group has been developed providing a general access to all four azafluorenones. The application of this protocol is further demonstrated to the synthesis of azafluorenone related fused nitrogen heterocycles and fluorenones. In addition, design and synthesis of a novel fluorene based organic emitter for potential use in organic light emitting devices (OLEDs) is also reported.
authors.affiliation: Department of Pharmaceutical Technology (Process Chemistry), National Institute of Pharmaceutical Education and Research Sahibzada Ajit Singh Nagar, Punjab 160062, India.
authors.forename: Joydev K
authors.identifier: 0000-0003-0481-5891
authors.initials: JK
authors.lastname: Laha
authors.affiliation: Department of Pharmaceutical Technology (Process Chemistry), National Institute of Pharmaceutical Education and Research Sahibzada Ajit Singh Nagar, Punjab 160062, India.
authors.forename: Krupal P
authors.initials: KP
authors.lastname: Jethava
authors.affiliation: Department of Pharmaceutical Technology (Process Chemistry), National Institute of Pharmaceutical Education and Research Sahibzada Ajit Singh Nagar, Punjab 160062, India.
authors.forename: Sagarkumar
authors.initials: S
authors.lastname: Patel
authors.affiliation: Department of Pharmaceutical Technology (Process Chemistry), National Institute of Pharmaceutical Education and Research Sahibzada Ajit Singh Nagar, Punjab 160062, India.
authors.forename: Ketul V
authors.initials: KV
authors.lastname: Patel