title: [Identification of a novel HLA allele A*29:49 using sequence based typing].
abstract: OBJECTIVE
  To report on a novel HLA-A allele, A*29:49, identified in a Chinese Han population by sequence based typing (SBT).
  
  
  METHODS
  A donor from China Marrow Donor Programme (CMDP) was typed with a bi-allelic PCR-SBT kit, and no full matched result was obtained for the HLA-A locus. The novel HLA allele was verified with an allele-specific amplification SBT kit.
  
  
  RESULTS
  A novel HLA-A allele was identified, which has differed by one nucleotide from the closest matched allele, HLA-A*29:01:01:01, at position 368(A→T), codon 99 (TAT→TTT), resulting in an amino acid substitution (Y→F). Another allele was verified as A*02:06:01.
  
  
  CONCLUSIONS
  A novel HLA-A allele was identified and officially named as HLA-A*29:49 by the WHO Nomenclature Committee for Factors of the HLA System.
authors.affiliation: Blood Center of Shandong Province, Jinan, Shandong 250014, China. sdhla@aliyun.com.
authors.forename: Yan
authors.initials: Y
authors.lastname: Chen
authors.forename: Yujie
authors.initials: Y
authors.lastname: Li
authors.forename: Xiaojie
authors.initials: X
authors.lastname: Xu
authors.forename: Peicong
authors.initials: P
authors.lastname: Zhai
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Chuanfu
authors.initials: C
authors.lastname: Zhu
mesh_terms: D000483:Alleles; D019943:Amino Acid Substitution / Q000235:genetics; D001483:Base Sequence; D002681:China; D015234:HLA-A Antigens / Q000235:genetics*; D006801:Humans; D017422:Sequence Analysis, DNA / Q000379:methods
chemical_list: D015234:HLA-A Antigens; C035524:HLA-A29 antigen