title: Discovery and Characterization of a Peptoid with Antifungal Activity againstCryptococcus neoformans.
abstract: Studies show there is an increasing rate of fungal infections, especially in immunocompromised patients and treatments for fungal genera, such asAspergillus,Candida, andCryptococcus, carry significant cytotoxicity with an increasing prevalence of antifungal resistance. We have previously reported a high-throughput assay for identifying peptoids with antimicrobial properties from combinatorial libraries. Here we report the application of this assay in identifying a peptoid with antifungal properties againstCryptococcus neoformans. Termed AEC5, this peptoid has comparable potency to existing clinical antifungal agents, excellent stability, and minimal cytotoxicity in mammalian cells.
authors.affiliation: Department of Chemistry and Department of Biology, Middle Tennessee State University , 1301 East Main Street, Murfreesboro, Tennessee 37132, United States.
authors.forename: Ashley E
authors.initials: AE
authors.lastname: Corson
authors.affiliation: Department of Chemistry and Department of Biology, Middle Tennessee State University , 1301 East Main Street, Murfreesboro, Tennessee 37132, United States.
authors.forename: Scott A
authors.initials: SA
authors.lastname: Armstrong
authors.affiliation: Department of Chemistry and Department of Biology, Middle Tennessee State University , 1301 East Main Street, Murfreesboro, Tennessee 37132, United States.
authors.forename: Matthew E
authors.initials: ME
authors.lastname: Wright
authors.affiliation: Department of Chemistry and Department of Biology, Middle Tennessee State University , 1301 East Main Street, Murfreesboro, Tennessee 37132, United States.
authors.forename: Erin E
authors.initials: EE
authors.lastname: McClelland
authors.affiliation: Department of Chemistry and Department of Biology, Middle Tennessee State University , 1301 East Main Street, Murfreesboro, Tennessee 37132, United States.
authors.forename: Kevin L
authors.initials: KL
authors.lastname: Bicker
keywords: Cryptococcus neoformans; Peptoids; fungal infections; high-throughput screening