title: Effect of ATP-binding Cassette Transporter A1 (ABCA1) Gene Polymorphisms on Plasma Lipid Variables and Common Demographic Parameters in Greek Nurses.
abstract: OBJECTIVE
  The present study is on line with our previous studies evaluating the influence of ATP-binding cassette transporter A1 (ABCA1) gene polymorphisms on the lipid variables of Greek student-nurses. The current study was undertaken to (1) estimate the influence of variant(s) such as rs2066715 (V825I), R219K, R1587K, I883M ofABCA1gene on lipid variables and (2) evaluate the effect of all fourABCA1polymorphisms on common demographic parameters.
  
  
  METHODS
  The study population involved 432 unrelated nurses (86 men) who were genotyped forABCA1polymorphisms and correlated according to lipid variables [total cholesterol (TC), triglycerides (TGs), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and apolipoprotein (apo) A] and demographic parameters (age, gender, BMI, waist circumference).
  
  
  RESULTS
  According to lipid variables concentration there was no difference between genotypes and alleles of V825I, R219K and I883M polymorphisms. The LDL-C concentration was 13% lower in RR compared with RK genotype (100.7vs. 113.9 mg/dl, p=0.013) of R1587K gene polymorphism. In regression analysis the effects of age, gender and only R1587K gene polymorphism on LDL-C concentrations were proved significant. Additionally, LDL-C was increased (by 1.29 mg/dl on average) by every year of increase of age. Moreover, females had lower LDL-C concentrations as compared with males.
  
  
  CONCLUSIONS
  Findings suggested that only R1587K polymorphism ofABCA1gene was associated with lipid variables, age, and gender of Greek nurses. These findings may be helpful in assessing the risk factors for premature coronary heart disease and distinct individuals with lower/higher atherosclerotic burden.
authors.affiliation: Molecular Immunology Laboratory, Onassis Cardiac Surgery Center, Athens, Greece.
authors.forename: Vana
authors.initials: V
authors.lastname: Kolovou
authors.affiliation: Molecular Immunology Laboratory, Onassis Cardiac Surgery Center, Athens, Greece.
authors.forename: Apostolia
authors.initials: A
authors.lastname: Marvaki
authors.affiliation: Cardiology Department, Onassis Cardiac Surgery Center, Athens, Greece.
authors.forename: Maria
authors.initials: M
authors.lastname: Boutsikou
authors.affiliation: Department of Nursing, A' Technological Educational Institute of Athens, Greece.
authors.forename: Georgios
authors.initials: G
authors.lastname: Vasilopoulos
authors.affiliation: Molecular Immunology Laboratory, Onassis Cardiac Surgery Center, Athens, Greece.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Degiannis
authors.affiliation: Department of Nursing, A' Technological Educational Institute of Athens, Greece.
authors.forename: Christina
authors.initials: C
authors.lastname: Marvaki
authors.affiliation: Cardiology Department, Onassis Cardiac Surgery Center, Athens, Greece.
authors.forename: Genovefa
authors.initials: G
authors.lastname: Kolovou
keywords: ABCA1 gene polymorphisms; ATP-binding cassette transporter A1; I883M; R1587K; R219K; V825I