title: Identification of Triptophenolide fromTripterygium wilfordiias a Pan-antagonist of Androgen Receptor.
abstract: A compound, triptophenolide, derived fromTripterygium wilfordiiwas identified as an antiandrogen. Triptophenolide inhibits the activity of both wild-type and F876L mutant androgen receptors. Triptophenolide exhibits its antiandrogenic activity through competitive binding with androgen in the hormone-binding pocket, decreasing the expression of androgen receptor, and reducing the nuclear translocation of androgen receptor.
authors.affiliation: Institute of Medicinal Biotechnology, Chinese Academy of Medical Science , Beijing, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: He
authors.affiliation: Institute of Medicinal Biotechnology, Chinese Academy of Medical Science , Beijing, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Wu
authors.affiliation: Institute of Medicinal Biotechnology, Chinese Academy of Medical Science , Beijing, China.
authors.forename: Yangguang
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Institute of Medicinal Biotechnology, Chinese Academy of Medical Science , Beijing, China.
authors.forename: Quanjie
authors.initials: Q
authors.lastname: Li
authors.affiliation: Institute of Medicinal Biotechnology, Chinese Academy of Medical Science , Beijing, China.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Li
authors.affiliation: Institute of Medicinal Biotechnology, Chinese Academy of Medical Science , Beijing, China.
authors.forename: Laixing
authors.initials: L
authors.lastname: Hu
authors.affiliation: Institute of Medicinal Biotechnology, Chinese Academy of Medical Science , Beijing, China.
authors.forename: Shan
authors.initials: S
authors.lastname: Cen
authors.affiliation: Institute of Medicinal Biotechnology, Chinese Academy of Medical Science , Beijing, China.
authors.forename: Jinming
authors.initials: J
authors.lastname: Zhou
keywords: Androgen receptor; gene report system; traditional Chinese medicine; triptophenolide