title: [Clinical manifestations of organizing pneumonia].
abstract: Organizing pneumonia is a clinical entity asociated with nonspecific symptoms and radiological findings and abnormalities in pulmonary function tests. It is defined by the characteristic histopathological pattern: filling of alveoli and respiratory bronchioles by plugs of granulation tissue. It can be idiopathic (COP) or secondary to other causes (SOP). It is an unusual finding and the clinical and radiographic findings are nonspecific. For specific diagnosis an invasive procedure has to be done, but often empirical treatment is started when there's a clinical suspicion. We describe the clinical characteristics of 13 patients with histological diagnosis of organizing pneumonia. Data was obtained from their medical records. The median age was 76 years and the median time to diagnosis from the onset of symptoms was 31 days. In 10 cases the diagnosis was made by transbronchial biopsy. 8 patients required hospitalization, 4 of them received high doses of steroids and 3 required ventilatory support. One patient died from a cause attributable to this entity and 5 relapsed. Dyspnea, cough and fever were the most frequent symptoms. Most patients had more than one tomographic pattern being the most common ground glass opacities and alveolar consolidation. Nine patients were diagnosed with COP and 4 with SOP. The most frequent underlying cause of SOP was drug toxicity. The clinical characteristics of the reported cases are consistent with previously published series. As an interesting feature, there was a group of patients that needed high doses of steroids and ventilatory support.
authors.affiliation: Servicio de Clínica Médica, Instituto de Investigaciones Médicas Alfredo Lanari, Universidad de Buenos Aires, Argentina. E-mail: huntmart@gmail.com.
authors.forename: Martín
authors.initials: M
authors.lastname: Hunter
authors.affiliation: Servicio de Clínica Médica, Instituto de Investigaciones Médicas Alfredo Lanari, Universidad de Buenos Aires, Argentina.
authors.forename: Ana
authors.initials: A
authors.lastname: Ludueña
authors.affiliation: Servicio de Clínica Médica, Instituto de Investigaciones Médicas Alfredo Lanari, Universidad de Buenos Aires, Argentina.
authors.forename: Irene
authors.initials: I
authors.lastname: Telias
authors.affiliation: Servicio de Neumonología, Instituto de Investigaciones Médicas Alfredo Lanari, Universidad de Buenos Aires, Argentina.
authors.forename: Patricia
authors.initials: P
authors.lastname: Aruj
authors.affiliation: Servicio de Anatomía Patológica, Instituto de Investigaciones Médicas Alfredo Lanari, Universidad de Buenos Aires, Argentina.
authors.forename: Silvia
authors.initials: S
authors.lastname: Rausch
authors.affiliation: Servicio de Clínica Médica, Instituto de Investigaciones Médicas Alfredo Lanari, Universidad de Buenos Aires, Argentina.
authors.forename: Juan Pablo
authors.initials: JP
authors.lastname: Suárez
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D003371:Cough / Q000209:etiology; D018549:Cryptogenic Organizing Pneumonia / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology*; D004417:Dyspnea / Q000209:etiology; D005260:Female; D005334:Fever / Q000209:etiology; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D013906:Thoracoscopy; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000305:Adrenal Cortex Hormones
keywords: bronchiolitis obliterans organizing pneumonia; cryptogenic organizing pneumonia