title: Haploidentical transplantation of hematopoietic stem cells.
abstract: OBJECTIVE
  To review and discuss the literature on hematopoietic stem cell transplantation (HSCT) with haploidentical donors in Brazil.
  
  
  METHODS
  Literature review.
  
  
  RESULTS
  The haploidentical hematopoietic stem cell transplantations have become a safe option in hematology since the 80s, with the possibility of ex-vivo T-cell depletion. However, its broad use worldwide occurred with the advent of haploidentical nonmyeloablative transplants using in vivo T-cell depletion with the administration of post-transplant cyclophosphamide. The results were encouraging, despite the increased risk of infection and post-transplantation recurrence. Recent publications on acute myeloid leukemia, myelodysplastic syndrome and Hodgkin's lymphoma have shown similar results among haploidentical, unrelated and related full-match transplants. Obviously, these findings of retrospective studies should be confirmed by clinical trials.
  
  
  CONCLUSIONS
  Transplantation with haploidentical donor has shown to be feasible in Brazil and the first publications and results are showing encouraging results.
authors.affiliation: Universidade de São Paulo, Brazil.
authors.forename: Nelson
authors.initials: N
authors.lastname: Hamerschlak
mesh_terms: D001938:Brazil; D046148:Donor Selection / Q000379:methods*; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods* / Q000401:mortality; D006648:Histocompatibility; D006801:Humans; D018570:Risk Assessment; D013997:Time Factors; D014019:Tissue Donors; D016896:Treatment Outcome