title: Fox transcription factors: from development to disease.
abstract: Forkhead box (Fox) transcription factors are evolutionarily conserved in organisms ranging from yeast to humans. They regulate diverse biological processes both during development and throughout adult life. Mutations in many Fox genes are associated with human disease and, as such, various animal models have been generated to study the function of these transcription factors in mechanistic detail. In many cases, the absence of even a single Fox transcription factor is lethal. In this Primer, we provide an overview of the Fox family, highlighting several key Fox transcription factor families that are important for mammalian development.
authors.affiliation: Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Maria L
authors.initials: ML
authors.lastname: Golson
authors.affiliation: Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA kaestner@mail.med.upenn.edu.
authors.forename: Klaus H
authors.identifier: 0000-0002-1228-021X
authors.initials: KH
authors.lastname: Kaestner
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000235:genetics*; D047108:Embryonic Development / Q000235:genetics*; D004734:Energy Metabolism / Q000235:genetics*; D051858:Forkhead Transcription Factors / Q000235:genetics*; D006801:Humans
chemical_list: D051858:Forkhead Transcription Factors
keywords: Foregut development; Forkhead; Fox; Language acquisition; Pioneer factors; Transcription factors