title: Dacryoadenitis associated with IgG4-related disease in an Afro-Colombian adolescent.
abstract: IgG4-related disease (IgG4-RD) is a recently recognized clinical condition with multiple aspects not yet elucidated. It is characterized by a fibrous inflammatory process that involves multiple organs and clinical, serological and histopathological findings, which represent a major challenge for the clinician. Classically described as an expansive tumor lesion with storiform fibrosis, lymphoplasmacytic infiltration (IgG4-positive) and elevated serum IgG4. Clinical features are variable, and pancreatic as well as extrapancreatic involvement has been reported, more frequently in Asian men over 50 years and rarely described in black people. We report the case of an Afro-Colombian teenage woman, who had a unilateral ocular protrusion of unknown cause, with histopathologic findings that revealed infiltration of lymphocyte and plasma cells into the lacrimal gland. It was positive for IgG4, ruling out other conditions, and confirming IgG4-related dacryoadenitis.
authors.affiliation: Departamento de Medicina Interna, Universidad del Valle, Cali, Colombia.
authors.forename: Gabriel Sebastián
authors.initials: GS
authors.lastname: Díaz-Ramírez
authors.affiliation: Departamento de Medicina Interna, Universidad del Valle, Cali, Colombia; Medicina Interna-Reumatología, Universidad del Valle, Cali, Colombia.
authors.forename: Luis Fernando
authors.initials: LF
authors.lastname: Medina-Quintero
authors.affiliation: Departamento de Medicina Interna, Universidad del Valle, Cali, Colombia.
authors.forename: Alexander
authors.initials: A
authors.lastname: Salinas-César
authors.affiliation: Departamento de Medicina Interna, Universidad del Valle, Cali, Colombia; Departamento de Microbiología, Universidad del Valle, Cali, Colombia. Electronic address: andres.zea@correounivalle.edu.co.
authors.forename: Andrés Felipe
authors.initials: AF
authors.lastname: Zea-Vera
mesh_terms: D000293:Adolescent; D000349:Africa / Q000208:ethnology; D001379:Azathioprine / Q000627:therapeutic use; D001706:Biopsy; D003105:Colombia; D003607:Dacryocystitis / Q000000981:diagnostic imaging / Q000208:ethnology / Q000209:etiology* / Q000473:pathology; D003951:Diagnostic Errors; D005260:Female; D006104:Granuloma, Plasma Cell / Q000175:diagnosis; D006801:Humans; D000077733:Immunoglobulin G4-Related Disease / Q000150:complications* / Q000208:ethnology; D007765:Lacrimal Apparatus / Q000000981:diagnostic imaging / Q000473:pathology; D008214:Lymphocytes / Q000473:pathology; D008279:Magnetic Resonance Imaging; D010950:Plasma Cells / Q000473:pathology; D011241:Prednisone / Q000627:therapeutic use
chemical_list: D001379:Azathioprine; D011241:Prednisone
keywords: Adolescent; Adolescente; Dacrioadenitis; Dacryoadenitis; Enfermedad relacionada con IgG4; IgG4-related disease