title: The effect of ethephon on immune system in male offspring of mice.
abstract: Ethephon can liberate ethylene which could interfere the plant growth process. The aim of the present study was to determine the effect of ethephon on developing immune system of male offspring. Ethephon could enhance NK cell activity in male mice. For 4-week-old male mice, lymphocytes of peripheral blood increased while the hemolytic plaque number decreased. Delayed type hypersensitivity(DTH) was inhibited in all groups. The expression of protein Bcl11b and p-p38 in thymus of treatment groups were lower than control group. Our results indicated that cellular immunity of male offspring is more sensitive to ethephon when exposed in pregnancy and lactation period. It should be emphasized that exposure to ethephon during the in utero stage and lactation stage still could damage the immune function of animal in the period before fully mature even in the dosage that could not influence the immune function of adult animal.
authors.affiliation: Department of Toxicology, School of Public Health, Peking University, 100191, PR China; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Beijing 100191, PR China.
authors.forename: Siqi
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Toxicology, School of Public Health, Peking University, 100191, PR China; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Beijing 100191, PR China.
authors.forename: Haifeng
authors.initials: H
authors.lastname: Jin
authors.affiliation: Department of Toxicology, School of Public Health, Peking University, 100191, PR China; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Beijing 100191, PR China.
authors.forename: Qiuqiong
authors.initials: Q
authors.lastname: Tang
authors.affiliation: Department of Toxicology, School of Public Health, Peking University, 100191, PR China; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Beijing 100191, PR China.
authors.forename: Jun
authors.initials: J
authors.lastname: Fu
authors.affiliation: Department of Toxicology, School of Public Health, Peking University, 100191, PR China; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Beijing 100191, PR China.
authors.forename: Zeming
authors.initials: Z
authors.lastname: Ren
authors.affiliation: Department of Toxicology, School of Public Health, Peking University, 100191, PR China; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Beijing 100191, PR China.
authors.forename: Cike
authors.initials: C
authors.lastname: Peng
authors.affiliation: Department of Toxicology, School of Public Health, Peking University, 100191, PR China; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Beijing 100191, PR China.
authors.forename: Lanqin
authors.initials: L
authors.lastname: Shang
authors.affiliation: Department of Toxicology, School of Public Health, Peking University, 100191, PR China; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Beijing 100191, PR China.
authors.forename: Weidong
authors.initials: W
authors.lastname: Hao
authors.affiliation: Department of Toxicology, School of Public Health, Peking University, 100191, PR China; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Beijing 100191, PR China. Electronic address: weixt1010@gmail.com.
authors.forename: Xuetao
authors.initials: X
authors.lastname: Wei
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D005260:Female; D006462:Hemolytic Plaque Technique; D006968:Hypersensitivity, Delayed / Q000139:chemically induced; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology; D007774:Lactation / Q000276:immunology; D018655:Lymphocyte Count; D008297:Male; D008807:Mice, Inbred BALB C; D009943:Organophosphorus Compounds / Q000633:toxicity*; D010937:Plant Growth Regulators / Q000633:toxicity*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012097:Repressor Proteins / Q000378:metabolism; D013154:Spleen / Q000166:cytology / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects / Q000502:physiology; D013950:Thymus Gland / Q000187:drug effects / Q000378:metabolism; D025521:Tumor Suppressor Proteins / Q000378:metabolism; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism
chemical_list: C511143:Bcl11b protein, mouse; D009943:Organophosphorus Compounds; D010937:Plant Growth Regulators; D012097:Repressor Proteins; D025521:Tumor Suppressor Proteins; D048051:p38 Mitogen-Activated Protein Kinases; C005073:ethephon
keywords: DTH; Developmental immunotoxicity; Ethephon; Male pups