title: Association of TCF7L2 and GCG Gene Variants with Insulin Secretion, Insulin Resistance, and Obesity in New-onset Diabetes.
abstract: This cohort study was designed to evaluate the association of transcription factor 7-like 2 (TCF7L2) and proglucagon gene (GCG) variants with disordered glucose metabolism and the incidence of type 2 diabetes mellitus (T2DM) in a rural adult Chinese population. A total of 7,751 non-T2DM participants ⋝18 years old genotyped at baseline were recruited. The same questionnaire interview and physical and blood biochemical examinations were performed at both baseline and follow-up. During a median 6 years of follow-up, T2DM developed in 227 participants. After adjustment for potential contributory factors, nominally significant associations were seen between TT genotype and the recessive model of TCF7L2 rs7903146 and increased risk of T2DM [hazard ratio (HR)=4.068, 95% confidence interval (CI): 1.270-13.026; HR=4.051, 95% CI: 1.268-12.946, respectively]. The TT genotype of rs7903146 was also significantly associated with higher fasting plasma insulin level and the homeostasis model assessment of insulin resistance in case of new-onset diabetes. In addition, the TCF7L2 rs290487 TT genotype was associated with abdominal obesity and the GCG rs12104705 CC genotype was associated with both general obesity and abdominal obesity in case of new-onset diabetes.
authors.affiliation: Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou 450000, Henan, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Preventive Medicine, Shenzhen University; Shenzhen University Health Science Center, Shenzhen 518060, Guangdong, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Discipline of Public Health and Preventive Medicine, Center of Preventive Medicine Research and Assessment, Henan University of Traditional Chinese Medicine, Zhengzhou 450016, Henan, China.
authors.forename: Jin Jin
authors.initials: JJ
authors.lastname: Wang
authors.affiliation: Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou 450000, Henan, China.
authors.forename: Chong Jian
authors.initials: CJ
authors.lastname: Wang
authors.affiliation: Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou 450000, Henan, China.
authors.forename: Yong Cheng
authors.initials: YC
authors.lastname: Ren
authors.affiliation: Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou 450000, Henan, China; Department of Preventive Medicine, Shenzhen University; Shenzhen University Health Science Center, Shenzhen 518060, Guangdong, China.
authors.forename: Bing Yuan
authors.initials: BY
authors.lastname: Wang
authors.affiliation: Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou 450000, Henan, China.
authors.forename: Hong Yan
authors.initials: HY
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou 450000, Henan, China.
authors.forename: Xiang Yu
authors.initials: XY
authors.lastname: Yang
authors.affiliation: Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou 450000, Henan, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou 450000, Henan, China.
authors.forename: Cheng Yi
authors.initials: CY
authors.lastname: Han
authors.affiliation: Department of Preventive Medicine, Shenzhen University; Shenzhen University Health Science Center, Shenzhen 518060, Guangdong, China.
authors.forename: Jun Mei
authors.initials: JM
authors.lastname: Zhou
authors.affiliation: Department of Prevention and Health Care, Military Hospital of Henan Province, Zhengzhou 450052, Henan, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Pang
authors.affiliation: Department of Prevention and Health Care, Military Hospital of Henan Province, Zhengzhou 450052, Henan, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Yin
authors.affiliation: Department of Prevention and Health Care, Military Hospital of Henan Province, Zhengzhou 450052, Henan, China.
authors.forename: Jing Zhi
authors.initials: JZ
authors.lastname: Zhao
authors.affiliation: Department of Preventive Medicine, Shenzhen University; Shenzhen University Health Science Center, Shenzhen 518060, Guangdong, China.
authors.forename: Xin Ping
authors.initials: XP
authors.lastname: Luo
authors.affiliation: Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou 450000, Henan, China; Department of Preventive Medicine, Shenzhen University; Shenzhen University Health Science Center, Shenzhen 518060, Guangdong, China.
authors.forename: Dong Sheng
authors.initials: DS
authors.lastname: Hu
mesh_terms: D000328:Adult; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000235:genetics*; D005260:Female; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance / Q000235:genetics*; D000078790:Insulin Secretion; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D052336:Proglucagon / Q000235:genetics*; D058118:Transcription Factor 7-Like 2 Protein / Q000235:genetics*
chemical_list: D007328:Insulin; C544894:TCF7L2 protein, human; D058118:Transcription Factor 7-Like 2 Protein; D052336:Proglucagon