title: Multiple alleles at a single locus control seed dormancy in SwedishArabidopsis.
abstract: Seed dormancy is a complex life history trait that determines the timing of germination and is crucial for local adaptation. Genetic studies of dormancy are challenging, because the trait is highly plastic and strongly influenced by the maternal environment. Using a combination of statistical and experimental approaches, we show that multiple alleles at the previously identified dormancy locusDELAY OF GERMINATION1jointly explain as much as 57% of the variation observed in SwedishArabidopsis thaliana, but give rise to spurious associations that seriously mislead genome-wide association studies unless modeled correctly. Field experiments confirm that the major alleles affect germination as well as survival under natural conditions, and demonstrate that locally adaptive traits can sometimes be dissected genetically.
authors.affiliation: Gregor Mendel Institute, Austrian Academy of Sciences, Vienna Biocenter, Vienna, Austria.
authors.forename: Envel
authors.identifier: 0000-0001-8667-6850
authors.initials: E
authors.lastname: Kerdaffrec
authors.affiliation: Gregor Mendel Institute, Austrian Academy of Sciences, Vienna Biocenter, Vienna, Austria.
authors.forename: Danièle L
authors.identifier: 0000-0002-2938-3071
authors.initials: DL
authors.lastname: Filiault
authors.affiliation: Gregor Mendel Institute, Austrian Academy of Sciences, Vienna Biocenter, Vienna, Austria.
authors.forename: Arthur
authors.identifier: 0000-0003-0831-1463
authors.initials: A
authors.lastname: Korte
authors.affiliation: Gregor Mendel Institute, Austrian Academy of Sciences, Vienna Biocenter, Vienna, Austria.
authors.forename: Eriko
authors.initials: E
authors.lastname: Sasaki
authors.affiliation: Gregor Mendel Institute, Austrian Academy of Sciences, Vienna Biocenter, Vienna, Austria.
authors.forename: Viktoria
authors.initials: V
authors.lastname: Nizhynska
authors.affiliation: Gregor Mendel Institute, Austrian Academy of Sciences, Vienna Biocenter, Vienna, Austria.
authors.forename: Ümit
authors.identifier: 0000-0003-4031-0428
authors.initials: Ü
authors.lastname: Seren
authors.affiliation: Gregor Mendel Institute, Austrian Academy of Sciences, Vienna Biocenter, Vienna, Austria.
authors.forename: Magnus
authors.identifier: 0000-0001-7178-9748
authors.initials: M
authors.lastname: Nordborg
mesh_terms: D000483:Alleles; D017360:Arabidopsis / Q000235:genetics* / Q000502:physiology*; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D057445:Plant Dormancy; D013548:Sweden
keywords: <i>a. thaliana</i>; Arabidopsis; DOG1; evolutionary biology; genetic architecture; genomics; germination; life history; local adaptation; plant biology; seed dormancy