title: Off-Label Use of Bone Morphogenetic Protein 2 in the Reconstructions of Mandibular Continuity Defects.
abstract: This paper describes 3 patients of off-label use of bone morphogenetic protein 2 (rhBMP-2) in the reconstruction of mandibular continuity defects. In the first patient, rhBMP-2 was associated with iliac crest bone graft for late mandibular reconstruction after resection of osteosarcoma. In the 2 other patients, rhBMP-2 was used alone. In 1 patient the mandibular continuity defect was due to resection for treatment of osteomyelitis and in the other patient a continuity defect was created by unsuccessful osteogenic distraction for correction of mandibular hypoplasia. Despite the good results in those patients, the off-label use of rhBMP-2 is associated with increased rate of complications, so more studies are needed to assess the predictability of the use of rhBMP-2 in mandibular continuity defects. Therefore, at the moment the off-label use of rhBMP-2 should be restricted to complicated bone defects in which the conventional alternatives of reconstruction were unsuccessful.
authors.affiliation: Araraquara Dental School, São Paulo State University (UNESP), Araraquara, Brazil.
authors.forename: Marina Reis
authors.initials: MR
authors.lastname: Oliveira
authors.forename: Luíz Fernando de Oliveira
authors.initials: LF
authors.lastname: Gorla
authors.forename: Marisa Aparecida Cabrini
authors.initials: MA
authors.lastname: Gabrielli
authors.forename: Valfrido Antonio
authors.initials: VA
authors.lastname: Pereira-Filho
mesh_terms: D000328:Adult; D055396:Bone Morphogenetic Protein 2 / Q000494:pharmacology*; D016025:Bone Transplantation / Q000379:methods*; D006801:Humans; D007085:Ilium / Q000637:transplantation; D007223:Infant; D007432:Intraoperative Period; D008297:Male; D008334:Mandible / Q000601:surgery*; D008339:Mandibular Neoplasms / Q000188:drug therapy / Q000601:surgery*; D063175:Mandibular Reconstruction / Q000379:methods*; D008875:Middle Aged; D056687:Off-Label Use; D012516:Osteosarcoma / Q000188:drug therapy / Q000601:surgery*; D011994:Recombinant Proteins / Q000494:pharmacology
chemical_list: C525718:BMP2 protein, human; D055396:Bone Morphogenetic Protein 2; D011994:Recombinant Proteins