title: PLGA-PNIPAM Microspheres Loaded with the Gastrointestinal Nutrient NaB Ameliorate Cardiac Dysfunction by Activating Sirt3 in Acute Myocardial Infarction.
abstract: Acute myocardial infarction (AMI) is the death of cardiomyocytes caused by a lack of energy due to ischemia. Nutrients supplied by the blood are the main source of cellular energy for cardiomyocytes. Sodium butyrate (NaB), a gastrointestinal nutrient, is a short-chain fatty acid (butyric acid) that may act as an energy source in AMI therapy. Poly(lactic-co-glycolic acid)-Poly (N-isopropylacrylamide) microspheres loaded with NaB (PP-N) are synthesized to prolong the release of NaB and are injected into ischemic zones in a Sprague-Dawley rat AMI model. Here, this study shows that PP-N can significantly ameliorate cardiac dysfunction in AMI, and NaB can specially bind to Sirt3 structure, activating its deacetylation ability and inhibiting the generation of reactive oxygen species, autophagy, and angiogenesis promotion. The results indicate that NaB, acting as a nutrient, can protect cardiomyocytes in AMI. These results suggest that the gastrointestinal nutrient NaB may be a new therapy for AMI treatment, and PP-N may be the ideal therapeutic regimen.
authors.affiliation: Department of Anatomy National & Regional Engineering Laboratory of Tissue Engineering State and Local Joint Engineering Laboratory For Vascular Implants, Key Lab for Biomechanics and Tissue Engineering of Chongqing Third Military Medical University Chongqing 400038 China.
authors.forename: Panke
authors.initials: P
authors.lastname: Cheng
authors.affiliation: Department of Anatomy National & Regional Engineering Laboratory of Tissue Engineering State and Local Joint Engineering Laboratory For Vascular Implants, Key Lab for Biomechanics and Tissue Engineering of Chongqing Third Military Medical University Chongqing 400038 China.
authors.forename: Wen
authors.initials: W
authors.lastname: Zeng
authors.affiliation: Department of Anatomy National & Regional Engineering Laboratory of Tissue Engineering State and Local Joint Engineering Laboratory For Vascular Implants, Key Lab for Biomechanics and Tissue Engineering of Chongqing Third Military Medical University Chongqing 400038 China.
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Anatomy National & Regional Engineering Laboratory of Tissue Engineering State and Local Joint Engineering Laboratory For Vascular Implants, Key Lab for Biomechanics and Tissue Engineering of Chongqing Third Military Medical University Chongqing 400038 China.
authors.forename: Da
authors.initials: D
authors.lastname: Huo
authors.affiliation: Department of Anatomy National & Regional Engineering Laboratory of Tissue Engineering State and Local Joint Engineering Laboratory For Vascular Implants, Key Lab for Biomechanics and Tissue Engineering of Chongqing Third Military Medical University Chongqing 400038 China.
authors.forename: Lingqing
authors.initials: L
authors.lastname: Zeng
authors.affiliation: Department of Anatomy National & Regional Engineering Laboratory of Tissue Engineering State and Local Joint Engineering Laboratory For Vascular Implants, Key Lab for Biomechanics and Tissue Engineering of Chongqing Third Military Medical University Chongqing 400038 China.
authors.forename: Ju
authors.initials: J
authors.lastname: Tan
authors.affiliation: Department of Anatomy National & Regional Engineering Laboratory of Tissue Engineering State and Local Joint Engineering Laboratory For Vascular Implants, Key Lab for Biomechanics and Tissue Engineering of Chongqing Third Military Medical University Chongqing 400038 China.
authors.forename: Jingting
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Department of Anatomy National & Regional Engineering Laboratory of Tissue Engineering State and Local Joint Engineering Laboratory For Vascular Implants, Key Lab for Biomechanics and Tissue Engineering of Chongqing Third Military Medical University Chongqing 400038 China.
authors.forename: Jiansen
authors.initials: J
authors.lastname: Sun
authors.affiliation: Department of Anatomy National & Regional Engineering Laboratory of Tissue Engineering State and Local Joint Engineering Laboratory For Vascular Implants, Key Lab for Biomechanics and Tissue Engineering of Chongqing Third Military Medical University Chongqing 400038 China.
authors.forename: Ge
authors.initials: G
authors.lastname: Liu
authors.affiliation: Department of Anatomy National & Regional Engineering Laboratory of Tissue Engineering State and Local Joint Engineering Laboratory For Vascular Implants, Key Lab for Biomechanics and Tissue Engineering of Chongqing Third Military Medical University Chongqing 400038 China.
authors.forename: Yanzhao
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Anatomy National & Regional Engineering Laboratory of Tissue Engineering State and Local Joint Engineering Laboratory For Vascular Implants, Key Lab for Biomechanics and Tissue Engineering of Chongqing Third Military Medical University Chongqing 400038 China.
authors.forename: Ge
authors.initials: G
authors.lastname: Guan
authors.affiliation: Department of Anatomy National & Regional Engineering Laboratory of Tissue Engineering State and Local Joint Engineering Laboratory For Vascular Implants, Key Lab for Biomechanics and Tissue Engineering of Chongqing Third Military Medical University Chongqing 400038 China.
authors.forename: Yuxin
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Anatomy National & Regional Engineering Laboratory of Tissue Engineering State and Local Joint Engineering Laboratory For Vascular Implants, Key Lab for Biomechanics and Tissue Engineering of Chongqing Third Military Medical University Chongqing 400038 China.
authors.forename: Chuhong
authors.initials: C
authors.lastname: Zhu
keywords: Sirt3; fatty acids; ischemia; microspheres