title: A New Iridoid Dimer and Other Constituents from the Traditional Kurdish Plant Pterocephalus nestorianus Nábělek.
abstract: Accompanied by other rare compounds, a new iridoid dimer, named kurdnestorianoside (1), showing an unprecedented secologanol configuration, has been isolated for the first time from the Kurdish medicinal plant Pterocephalus nestorianus, which is used in Kurdistan for treating oral diseases and inflammation. The structure of 1 was established from 1D- and 2D-NMR spectroscopic data. Kaempferol 3-O-[3,6-di-O-(E)-p-coumaroyl]-β-d-glucopyranoside (7) showed a remarkable antiproliferative activity against several human tumor cell lines.
authors.affiliation: Department of Chemistry, College of Science, Salahaddin University, Kirkuk Road, Erbil, Kurdistan Region, Iraq.
authors.forename: Fuad O
authors.initials: FO
authors.lastname: Abdullah
authors.affiliation: Department of Chemistry, College of Science, Salahaddin University, Kirkuk Road, Erbil, Kurdistan Region, Iraq.
authors.forename: Faiq H S
authors.initials: FH
authors.lastname: Hussain
authors.affiliation: Dipartimento di Scienze e Innovazione Tecnologica, Università del Piemonte Orientale, Via T. Michel 11, 15121, Alessandria, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Clericuzio
authors.affiliation: Centro CEMEC and Dipartimento di Chimica, Università di Pavia, Via Taramelli 12, 27100, Pavia, Italy.
authors.forename: Alessio
authors.initials: A
authors.lastname: Porta
authors.affiliation: Centro CEMEC and Dipartimento di Chimica, Università di Pavia, Via Taramelli 12, 27100, Pavia, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Vidari
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D049917:Dipsacaceae / Q000737:chemistry* / Q000378:metabolism; D004354:Drug Screening Assays, Antitumor; D035264:Flowers / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D039823:Iridoids / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D044949:Kaempferols / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal / Q000737:chemistry / Q000378:metabolism
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D039823:Iridoids; D044949:Kaempferols; C000616371:kurdnestorianoside; C006552:kaempferol
keywords: 
  Pterocephalus nestorianus
  ; Cytotoxic activities; Dipsacaceae; Iridoid dimers; Kurdish medicinal plant