title: Clinical Presentation and Outcomes of Stage III or Stage IV Retinoblastoma in 80 Asian Indian Patients.
abstract: OBJECTIVE
  To describe the clinical features and outcomes of patients with stage III or IV retinoblastoma.
  
  
  METHODS
  This was a retrospective study of 80 patients.
  
  
  RESULTS
  Based on the International Retinoblastoma Staging System (IRSS), the tumors (n = 81) belonged to stage IIIa (n = 38, 47%), IIIb (n = 1, 1%), IVa2 (n = 10, 12%), IVb1 (n = 14, 17%), and IVb3 (n = 18, 22%). Of 80 patients, 42 (53%) were compliant to treatment and 38 (47%) were non-compliant. All 38 patients who were non-compliant to treatment died of the disease at a mean duration of 13 months from diagnosis. Of the 42 patients compliant to treatment, 22 (52%) died before completion of treatment. Twenty patients with stage III disease (25%) could complete the multimodal treatment and 17 (71%) were alive and well at a median follow-up duration of 77 months.
  
  
  CONCLUSIONS
  Compliant multimodality treatment is beneficial in patients with IRSS stage III disease. IRSS stage IV retinoblastoma has poor prognosis despite treatment. [J Pediatr Ophthalmol Strabismus. 2017;54(3):177-184.].
authors.forename: Swathi
authors.initials: S
authors.lastname: Kaliki
authors.forename: Anamika
authors.initials: A
authors.lastname: Patel
authors.forename: Sadiya
authors.initials: S
authors.lastname: Iram
authors.forename: Vijay Anand Reddy
authors.initials: VAR
authors.lastname: Palkonda
mesh_terms: D044466:Asian People / Q000208:ethnology*; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007194:India / Q000453:epidemiology; D007223:Infant; D008297:Male; D009367:Neoplasm Staging / Q000379:methods*; D019572:Retinal Neoplasms / Q000175:diagnosis / Q000208:ethnology* / Q000628:therapy; D012175:Retinoblastoma / Q000175:diagnosis / Q000208:ethnology* / Q000628:therapy; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends