title: Non-heme dioxygenases in tumor hypoxia: They're all bound with the same fate.
abstract: Tumor tissues are known to harbor hypoxic areas. The hypoxic microenvironment promotes angiogenesis. Hypoxic tumor cells also manifest genome instability. DNA damage repair pathways, such as double-strand break repair, mismatch repair and base excision repair are known to be altered during hypoxia. This review is focused on the non-heme Fe(II) and 2-oxoglutarate-dependent dioxygenases which are involved in repair of DNA alkylation adducts. Activities of these DNA repair enzymes are completely oxygen-dependent and little information is available about inhibition of these enzymes during hypoxia. While impairment of function of non-heme dioxygenase during tumor hypoxia has been implicated in different studies, the possible outcomes with respect to mutagenesis and genomic instability are explored here.
authors.affiliation: Department of Biotechnology, Indian Institute of Technology Hyderabad, Kandi 502285, Hyderabad, Telangana, India. Electronic address: anindya@iith.ac.in.
authors.forename: Roy
authors.initials: R
authors.lastname: Anindya
mesh_terms: D000478:Alkylation; D018736:DNA Adducts / Q000378:metabolism*; D045643:DNA Repair Enzymes / Q000378:metabolism*; D049308:Dioxygenases / Q000378:metabolism*; D042822:Genomic Instability; D006801:Humans; D007656:Ketoglutaric Acids; D000072258:Tumor Hypoxia
chemical_list: D018736:DNA Adducts; D007656:Ketoglutaric Acids; D049308:Dioxygenases; D045643:DNA Repair Enzymes
keywords: 1meA; 3meC; ALKBH2; ALKBH3; AlkB; Cancer; DNA repair; Fe(II)/2-oxoglutarate-dependent dioxygenase; Hypoxia; Non-heme dioxygenase; Tumor