title: Rheumatologic diseases as the cause of fever of unknown origin.
abstract: In 30% of patients with fever or inflammation of unknown origin (FUO/IUO), the cause is eventually found to be a rheumatologic disease such as autoimmune or granulomatous disease or vasculitis. Most of these patients suffer from an uncommon presentation of a common disease, instead of an uncommon disease. We demonstrate the diagnostic challenge with several cases. The workup of FUO is based on the identification of potential diagnostic clues (PDCs). In the absence of PDCs, a standardized diagnostic protocol should be followed, including early FDG-PET/CT. Other imaging techniques or invasive diagnostic techniques should be reserved for those in whom PDCs are present.
authors.affiliation: Department of Internal Medicine, Radboud University Medical Center, PO Box 9101, 6500 HB Nijmegen, The Netherlands. Electronic address: Karin.Mulders-Manders@radboudumc.nl.
authors.forename: C M
authors.initials: CM
authors.lastname: Mulders-Manders
authors.affiliation: Department of Internal Medicine, Radboud University Medical Center, PO Box 9101, 6500 HB Nijmegen, The Netherlands.
authors.forename: A
authors.initials: A
authors.lastname: Simon
authors.affiliation: Department of Internal Medicine, Radboud University Medical Center, PO Box 9101, 6500 HB Nijmegen, The Netherlands.
authors.forename: C P
authors.initials: CP
authors.lastname: Bleeker-Rovers
mesh_terms: D000368:Aged; D005260:Female; D005335:Fever of Unknown Origin / Q000175:diagnosis* / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012216:Rheumatic Diseases / Q000150:complications* / Q000175:diagnosis*
keywords: Autoimmune disease; FDG–PET; Fever of unknown origin; Inflammation of unknown origin; Rheumatology