title: Targeted Photodynamic Killing of Breast Cancer Cells Employing Heptamannosylated β-Cyclodextrin-Mediated Nanoparticle Formation of an Adamantane-Functionalized BODIPY Photosensitizer.
abstract: The targeted delivery of a photosensitizer (PS) into specific cancer cells is an effective way to enhance the efficacy and minimize the side effects of photodynamic therapy. Herein, heptamannosylated β-cyclodextrin (β-CD) was used to mediate the formation of an adamantane (Ad)-functionalized BODIPY PS nanoparticle via strong β-CD/Ad complexation. The mannose-functionalized PS nanoparticles are selectively internalized by mannose-receptor-rich MDA-MB-231 breast cancer cells via receptor-mediated endocytosis, facilitating singlet oxygen generation to trigger apoptosis in cancer cells upon red-light irradiation. These nanoparticles exhibit excellent targeted delivery of the PS, leading to cancer cell death after irradiation both in vitro and in vivo.
authors.affiliation: Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University , Wuxi 214122, P. R. China.|Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces , Potsdam-Golm 14476, Germany.
authors.forename: Quan
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University , Wuxi 214122, P. R. China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Cai
authors.affiliation: Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, School of Chemistry and Chemical Engineering, Jiangsu Normal University , Xuzhou 221116, P. R. China.
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Wang
authors.affiliation: Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, School of Chemistry and Chemical Engineering, Jiangsu Normal University , Xuzhou 221116, P. R. China.
authors.forename: Jia-Long
authors.initials: JL
authors.lastname: Xu
authors.affiliation: Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University , Wuxi 214122, P. R. China.|Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces , Potsdam-Golm 14476, Germany.
authors.forename: Zhou
authors.initials: Z
authors.lastname: Ye
authors.affiliation: Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University , Wuxi 214122, P. R. China.
authors.forename: Shengtao
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces , Potsdam-Golm 14476, Germany.
authors.forename: Peter H
authors.initials: PH
authors.lastname: Seeberger
authors.affiliation: Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University , Wuxi 214122, P. R. China.
authors.forename: Jian
authors.initials: J
authors.lastname: Yin
mesh_terms: D000218:Adamantane; D001896:Boron Compounds; D001943:Breast Neoplasms; D016923:Cell Death; D006801:Humans; D053758:Nanoparticles; D010778:Photochemotherapy; D017319:Photosensitizing Agents; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: C095489:4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; D001896:Boron Compounds; D017319:Photosensitizing Agents; D047392:beta-Cyclodextrins; D000218:Adamantane
keywords: BODIPY; mannose-mediated targeting; photodynamic therapy; photosensitizer; supramolecular chemistry