title: Targeting Vascular Remodeling to Treat Pulmonary Arterial Hypertension.
abstract: Pulmonary arterial hypertension (PAH) describes a group of conditions with a common hemodynamic phenotype of increased pulmonary artery pressure, driven by progressive remodeling of small pulmonary arteries, leading to right heart failure and death. Vascular remodeling is the key pathological feature of PAH, but treatments targeting this process are lacking. In this review, we summarize important advances in our understanding of PAH pathogenesis from novel genetic and epigenetic factors, to cell metabolism and DNA damage. We show how these processes may integrate and highlight exploitable targets that could alter the relentless vascular remodeling in PAH.
authors.affiliation: Pulmonary Vascular Research Group, Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK.
authors.forename: A A Roger
authors.initials: AAR
authors.lastname: Thompson
authors.affiliation: Pulmonary Vascular Research Group, Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK. Electronic address: a.lawrie@sheffield.ac.uk.
authors.forename: Allan
authors.initials: A
authors.lastname: Lawrie
mesh_terms: D000818:Animals; D052006:Bone Morphogenetic Protein Receptors, Type II / Q000235:genetics / Q000378:metabolism; D055808:Drug Discovery; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology*; D000860:Hypoxia / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D058990:Molecular Targeted Therapy; D011651:Pulmonary Artery / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D015398:Signal Transduction / Q000187:drug effects; D066253:Vascular Remodeling / Q000187:drug effects
chemical_list: D035683:MicroRNAs; C498218:BMPR2 protein, human; D052006:Bone Morphogenetic Protein Receptors, Type II
keywords: BMPR2; hypoxia; miRNA; pulmonary hypertension; vascular remodeling