title: Hum-mPLoc 3.0: prediction enhancement of human protein subcellular localization through modeling the hidden correlations of gene ontology and functional domain features.
abstract: Protein subcellular localization prediction has been an important research topic in computational biology over the last decade. Various automatic methods have been proposed to predict locations for large scale protein datasets, where statistical machine learning algorithms are widely used for model construction. A key step in these predictors is encoding the amino acid sequences into feature vectors. Many studies have shown that features extracted from biological domains, such as gene ontology and functional domains, can be very useful for improving the prediction accuracy. However, domain knowledge usually results in redundant features and high-dimensional feature spaces, which may degenerate the performance of machine learning models.
  
  
  
  In this paper, we propose a new amino acid sequence-based human protein subcellular location prediction approach Hum-mPLoc 3.0, which covers 12 human subcellular localizations. The sequences are represented by multi-view complementary features, i.e. context vocabulary annotation-based gene ontology (GO) terms, peptide-based functional domains, and residue-based statistical features. To systematically reflect the structural hierarchy of the domain knowledge bases, we propose a novel feature representation protocol denoted as HCM (Hidden Correlation Modeling), which will create more compact and discriminative feature vectors by modeling the hidden correlations between annotation terms. Experimental results on four benchmark datasets show that HCM improves prediction accuracy by 5-11% and F 1 by 8-19% compared with conventional GO-based methods. A large-scale application of Hum-mPLoc 3.0 on the whole human proteome reveals proteins co-localization preferences in the cell.
  
  
  
  www.csbio.sjtu.edu.cn/bioinf/Hum-mPLoc3/.
  
  
  
  hbshen@sjtu.edu.cn.
  
  
  
  Supplementary data are available at Bioinformatics online.
authors.affiliation: Institute of Image Processing and Pattern Recognition, Shanghai Jiao Tong University, Ministry of Education of China, Shanghai, China.|Key Laboratory of System Control and Information Processing, Ministry of Education of China, Shanghai, China.
authors.forename: Hang
authors.initials: H
authors.lastname: Zhou
authors.affiliation: Department of Computer Science and Engineering, Shanghai Jiao Tong University, Shanghai, China.|Key Laboratory of Shanghai Education Commission for Intelligent Interaction and Cognitive Engineering, Shanghai, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Institute of Image Processing and Pattern Recognition, Shanghai Jiao Tong University, Ministry of Education of China, Shanghai, China.|Key Laboratory of System Control and Information Processing, Ministry of Education of China, Shanghai, China.
authors.forename: Hong-Bin
authors.initials: HB
authors.lastname: Shen
mesh_terms: D000465:Algorithms; D002451:Cell Compartmentation; D019295:Computational Biology / Q000379:methods*; D063990:Gene Ontology; D006801:Humans; D000069550:Machine Learning; D008954:Models, Biological; D021381:Protein Transport; D011506:Proteins / Q000378:metabolism*; D012984:Software
chemical_list: D011506:Proteins