title: The potential roles of dopamine in malignant glioma.
abstract: Despite the numerous promising discoveries in contemporary cancer research and the emerging innovative cancer treatment strategies, the global burden of malignant glioma is expected to increase, partially due to its poor prognosis and human aging. Dopamine, a monoamine catecholamine neurotransmitter, is currently regarded as an important endogenous regulator of tumor growth. Dopamine may be an important treatment for brain tumors and could impact the pathogenesis of glioma by regulating tumor angiogenesis and vasculogenesis. Additionally, dopamine might exert an anti-glioma, cytotoxic effect by modulating apoptosis and autophagy. Dopamine and its receptors are also known to influence the immune system, as it is related to the pathogenesis of glioma. Dopamine may also increase the efficacy of anti-cancer drugs. Here, we review the potential roles of dopamine in malignant glioma and further identify the previously unknown function of dopamine as a potent regulator in the pathogenesis of glioma. Currently, the precise mechanisms regarding the protective effect of dopamine on glioma are poorly understood. However, our experimental results strongly emphasize the importance of this topic in future investigations.
authors.affiliation: Department of Neurosurgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, 116027, People's Republic of China.|Department of Neurosurgery, The Third People's Hospital of Dalian, Non-Directly Affiliated Hospital of Dalian Medical University, Dalian, 116033, People's Republic of China.|Department of Pharmacy, Dalian Medical University, 9 Western District, Lvshun South Road, Dalian, 116044, People's Republic of China.|Department of Physiology, Dalian Medical University, 9 Western District, Lvshun South Road, Dalian, 116044, People's Republic of China.
authors.forename: Yu-Long
authors.initials: YL
authors.lastname: Lan
authors.affiliation: Department of Neurosurgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, 116027, People's Republic of China.|Department of Neurosurgery, The Third People's Hospital of Dalian, Non-Directly Affiliated Hospital of Dalian Medical University, Dalian, 116033, People's Republic of China.
authors.forename: Xun
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, 116027, People's Republic of China.
authors.forename: Jin-Shan
authors.initials: JS
authors.lastname: Xing
authors.affiliation: Department of Neurosurgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, 116027, People's Republic of China.
authors.forename: Jia-Cheng
authors.initials: JC
authors.lastname: Lou
authors.affiliation: Department of Pharmacy, Dalian Medical University, 9 Western District, Lvshun South Road, Dalian, 116044, People's Republic of China. maxc1978@163.com.
authors.forename: Xiao-Chi
authors.initials: XC
authors.lastname: Ma
authors.affiliation: Department of Neurosurgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, 116027, People's Republic of China. zhangbodl@126.com.
authors.forename: Bo
authors.initials: B
authors.lastname: Zhang
mesh_terms: D001932:Brain Neoplasms / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D005910:Glioma / Q000378:metabolism*; D006801:Humans
chemical_list: D004298:Dopamine
keywords: Dopamine; Malignant glioma; Mechanism; Treatment