title: Design of novel chemotherapeutic delivery systems for colon cancer therapy based on oral polymeric nanoparticles.
abstract: Oral delivery of cancer chemotherapeutic drugs (CCDs) is subject matter in the 21st century, which changes the dosage regimens of oncotherapy with enhancement in patient's life and deducts the cost of therapy. The present report explored on the nano-oncology such as polymeric nanoparticles (PNPs) as an oral CCDs delivery vehicle, showing great potential for colon cancer treatment. Proof-of-concept in vitro and in vivo results for delivery of CCDs using various oral PNPs are included in this review from the literatures. Subsequently, the gastrointestinal barriers for oral chemotherapy have been highlighted. Furthermore, PNPs achieving better accumulation in the cancer region by desirable quality of their passive- and active-targeting phenomena have also been highlighted.
authors.affiliation: Department of Pharmaceutics, Indian Institute of Technology (Banaras Hindu University), Varanasi 221005, UP, India.
authors.forename: Brahmeshwar
authors.initials: B
authors.lastname: Mishra
authors.affiliation: Formulation Research & Development, Complex Generics Division, Virchow Biotech Pvt. Ltd., Survey No. 172 Part, Gagillapur (V), Quthbullapur (M), R.R. Dist, Hyderabad 500043, Telangana, India.
authors.forename: Sundeep
authors.initials: S
authors.lastname: Chaurasia
mesh_terms: D003110:Colonic Neoplasms / Q000188:drug therapy*; D016503:Drug Delivery Systems; D006801:Humans; D053758:Nanoparticles; D011108:Polymers
chemical_list: D011108:Polymers
keywords: colon cancer; nanoparticles; oral chemotherapy; polymeric