title: A Breakdown in Cooperativity Leads to Cardiac Identity Crisis.
abstract: Using induced pluripotent stem cells, Ang et al. elucidate how a mutation in the transcription factor GATA4 causes congenital heart disease. They find that, although the recruitment of GATA4 to cardiac super-enhancers is retained, it no longer functions in partnership with another key transcription factor, leading to misexpression of non-cardiomyocyte genes.
authors.affiliation: Department of Stem Cell and Regenerative Biology and the Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
authors.forename: Ana
authors.initials: A
authors.lastname: Vujic
authors.affiliation: Department of Stem Cell and Regenerative Biology and the Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
authors.forename: Ahmed I
authors.initials: AI
authors.lastname: Mahmoud
authors.affiliation: Department of Stem Cell and Regenerative Biology and the Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA. Electronic address: richard_lee@harvard.edu.
authors.forename: Richard T
authors.initials: RT
authors.lastname: Lee
mesh_terms: D050991:GATA4 Transcription Factor / Q000235:genetics*; D006321:Heart; D006801:Humans; D007063:Identity Crisis; D032383:Myocytes, Cardiac / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics
chemical_list: D050991:GATA4 Transcription Factor; D014157:Transcription Factors