title: Genetic association study of P2x7 A1513C (rs 3751143) polymorphism and susceptibility to pulmonary tuberculosis: A meta-analysis based on the findings of 11 case-control studies.
abstract: To summarize the precise association between pulmonary tuberculosis (PTB) and P2x7 A1513C gene polymorphism.
  
  
  
  PubMed and Google Scholar web-databases were searched for the studies reporting the association of P2x7 A1513C polymorphism and PTB risk. A meta-analysis was performed for the selected case-control studies and pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated for all the genetic models.
  
  
  
  Eleven studies comprising 2678 controls and 2113 PTB cases were included in this meta-analysis. We observed overall no significant risk in all the five genetic models. When stratified population by the ethnicity, Caucasian population failed to show any risk of PTB in all the genetics models. In Asian ethnicity, variant allele (C vs. A: P = 0.001; OR = 1.375, 95% CI = 1.159-1.632) and heterozygous genotype (AC vs. AA: P = 0.001; OR = 1.570, 95% CI = 1.269-1.944) demonstrated significant increased risk of PTB. Likewise, recessive genetic model (CC + AC vs. AA: P = 0.001; OR = 1.540, 95% CI = 1.255-1.890) also demonstrated increased risk of PTB in Asians.
  
  
  
  Our meta-analysis did not suggest the association of P2x7 A1513C polymorphism with PTB risk in overall or separately in Caucasian population. However, it plays a significant risk factor for predisposing PTB in Asians. Future larger sample and expression studies are needed to validate this association.
authors.affiliation: Department of Clinical Nutrition, College of Applied Medical Sciences, University of Ha'il, Ha'il 2440, Saudi Arabia.
authors.forename: Eyad M A
authors.initials: EM
authors.lastname: Alshammari
authors.affiliation: Research and Scientific Studies Unit, College of Nursing & Allied Health Sciences, Jazan University, Jazan 45142, Saudi Arabia.
authors.forename: Raju K
authors.initials: RK
authors.lastname: Mandal
authors.affiliation: Research and Scientific Studies Unit, College of Nursing & Allied Health Sciences, Jazan University, Jazan 45142, Saudi Arabia.
authors.forename: Mohd
authors.initials: M
authors.lastname: Wahid
authors.affiliation: Research and Scientific Studies Unit, College of Nursing & Allied Health Sciences, Jazan University, Jazan 45142, Saudi Arabia; The University College of Medical Sciences & GTB Hospital (University of Delhi), Delhi 110095, India.
authors.forename: Sajad A
authors.initials: SA
authors.lastname: Dar
authors.affiliation: Research and Scientific Studies Unit, College of Nursing & Allied Health Sciences, Jazan University, Jazan 45142, Saudi Arabia.
authors.forename: Arshad
authors.initials: A
authors.lastname: Jawed
authors.affiliation: Research and Scientific Studies Unit, College of Nursing & Allied Health Sciences, Jazan University, Jazan 45142, Saudi Arabia.
authors.forename: Mohammed Y
authors.initials: MY
authors.lastname: Areeshi
authors.affiliation: Department of Clinical Nutrition, College of Applied Medical Sciences, University of Ha'il, Ha'il 2440, Saudi Arabia.
authors.forename: Saif
authors.initials: S
authors.lastname: Khan
authors.affiliation: Centre for Life Sciences, Central University of Jharkhand, Brambe, Ranchi 835205, Jharkhand, India.
authors.forename: Md Ekhlaque Ahmed
authors.initials: ME
authors.lastname: Khan
authors.affiliation: Centre for Life Sciences, Central University of Jharkhand, Brambe, Ranchi 835205, Jharkhand, India.
authors.forename: Aditya K
authors.initials: AK
authors.lastname: Panda
authors.affiliation: Research and Scientific Studies Unit, College of Nursing & Allied Health Sciences, Jazan University, Jazan 45142, Saudi Arabia. Electronic address: shafiul.haque@hotmail.com.
authors.forename: Shafiul
authors.initials: S
authors.lastname: Haque
keywords: Genetic model; Meta-analysis; P2x7 gene; Polymorphism; Pulmonary tuberculosis