title: Implementation of Arithmetic Functions on a Simple and Universal Molecular Beacon Platform.
abstract: Diverse advanced logic circuitsare fabricated to implement arithmetic functions based on a simple and single molecular beacon platform, including half adder, half subtractor, full adder, full subtractor, and a digital comparator. Dual fluorescence outputs are generated in parallel and a constant threshold value is set to build all the logic circuits. The developed enzyme-free DNA system provides a novel prototype for the design of high-level molecular logic circuits on a biomolecular platform.
authors.affiliation: State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied Chemistry Changchun 130022 China; Graduate School of the Chinese Academy of Sciences Beijing 100039 China; Department of Nanomedicine Houston Methodist Research Institute Houston TX 77030 USA; Department of Cell and Developmental Biology Weill Medical College of Cornell University NY 10065 USA.
authors.forename: Hailong
authors.initials: H
authors.lastname: Li
authors.affiliation: State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied Chemistry Changchun 130022 China; Graduate School of the Chinese Academy of Sciences Beijing 100039 China.
authors.forename: Shaojun
authors.initials: S
authors.lastname: Guo
authors.affiliation: State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied Chemistry Changchun 130022 China; Graduate School of the Chinese Academy of Sciences Beijing 100039 China.
authors.forename: Qinghui
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Department of Nanomedicine Houston Methodist Research Institute Houston TX 77030 USA; Department of Cell and Developmental Biology Weill Medical College of Cornell University NY 10065 USA.
authors.forename: Lidong
authors.initials: L
authors.lastname: Qin
authors.affiliation: State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied Chemistry Changchun 130022 China; Graduate School of the Chinese Academy of Sciences Beijing 100039 China.
authors.forename: Shaojun
authors.initials: S
authors.lastname: Dong
authors.affiliation: State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied Chemistry Changchun 130022 China; Graduate School of the Chinese Academy of Sciences Beijing 100039 China.
authors.forename: Yaqing
authors.initials: Y
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied Chemistry Changchun 130022 China; Graduate School of the Chinese Academy of Sciences Beijing 100039 China.
authors.forename: Erkang
authors.initials: E
authors.lastname: Wang
keywords: DNA nanotechnology; adders; biomaterials; molecular computing; subtractors