title: Retrovirus Integration: Some Assembly Required?
abstract: Integration is a key feature of the retroviral life cycle. This process involves packaging of the viral genome into chromatin, which is often assumed to occur as a post-integration step. In this issue of Cell Host & Microbe, Wang and colleagues (Wang et al., 2016) show that chromatinization occurs before integration, raising new questions about the role of histones in retroviral integration and transcription.
authors.affiliation: The Gladstone Institutes, University of California, San Francisco, 1650 Owens Street, San Francisco, CA 94158, USA.
authors.forename: Ibraheem
authors.initials: I
authors.lastname: Ali
authors.affiliation: The Gladstone Institutes, University of California, San Francisco, 1650 Owens Street, San Francisco, CA 94158, USA.
authors.forename: Ryan J
authors.initials: RJ
authors.lastname: Conrad
authors.affiliation: The Gladstone Institutes, University of California, San Francisco, 1650 Owens Street, San Francisco, CA 94158, USA. Electronic address: mott@gladstone.ucsf.edu.
authors.forename: Melanie
authors.initials: M
authors.lastname: Ott
mesh_terms: D000107:Acetylation; D000818:Animals; D036022:Capsid Proteins / Q000378:metabolism; D045744:Cell Line, Tumor; D002843:Chromatin / Q000235:genetics / Q000821:virology; D004279:DNA, Viral / Q000235:genetics / Q000502:physiology; D054278:Embryonal Carcinoma Stem Cells / Q000821:virology; D057890:Epigenomics; D005347:Fibroblasts; D015967:Gene Expression Regulation, Viral; D006657:Histones / Q000378:metabolism / Q000502:physiology; D006801:Humans; D007239:Infections / Q000378:metabolism; D008018:Life Cycle Stages; D051379:Mice; D000066450:Mouse Embryonic Stem Cells / Q000821:virology; D019590:Nucleocapsid Proteins / Q000378:metabolism; D012190:Retroviridae / Q000235:genetics* / Q000254:growth & development*; D012192:Retroviridae Infections / Q000628:therapy / Q000821:virology; D014158:Transcription, Genetic; D019065:Virus Assembly; D016662:Virus Integration / Q000235:genetics* / Q000502:physiology
chemical_list: D036022:Capsid Proteins; D002843:Chromatin; D004279:DNA, Viral; D006657:Histones; D019590:Nucleocapsid Proteins