title: Oxytocin is implicated in social memory deficits induced by early sensory deprivation in mice.
abstract: Early-life sensory input plays a crucial role in brain development. Although deprivation of orofacial sensory input at perinatal stages disrupts the establishment of the barrel cortex and relevant callosal connections, its long-term effect on adult behavior remains elusive. In this study, we investigated the behavioral phenotypes in adult mice with unilateral transection of the infraorbital nerve (ION) at postnatal day 3 (P3). Although ION-transected mice had normal locomotor activity, motor coordination, olfaction, anxiety-like behaviors, novel object memory, preference for social novelty and sociability, they presented deficits in social memory and spatial memory compared with control mice. In addition, the social memory deficit was associated with reduced oxytocin (OXT) levels in the hypothalamus and could be partially restored by intranasal administration of OXT. Thus, early sensory deprivation does result in behavioral alterations in mice, some of which may be associated with the disruption of oxytocin signaling.
authors.affiliation: Department of Histology and Embryology, Institute of Neuroscience, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, People's Republic of China.
authors.forename: Jin-Bao
authors.initials: JB
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Arrhythmias, Ministry of Education of China, East Hospital, Shanghai, 200092, People's Republic of China.|Department of Anatomy and Neurobiology, Collaborative Innovation Center for Brain Science, Tongji University School of Medicine, Shanghai, 200092, People's Republic of China.
authors.forename: Ling
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Histology and Embryology, Institute of Neuroscience, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, People's Republic of China.
authors.forename: Zhu-Man
authors.initials: ZM
authors.lastname: Lv
authors.affiliation: Department of Histology and Embryology, Institute of Neuroscience, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, People's Republic of China.
authors.forename: Xue-Yuan
authors.initials: XY
authors.lastname: Niu
authors.affiliation: Department of Histology and Embryology, Institute of Neuroscience, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, People's Republic of China.
authors.forename: Can-Can
authors.initials: CC
authors.lastname: Shao
authors.affiliation: Department of Histology and Embryology, Institute of Neuroscience, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, People's Republic of China.
authors.forename: Chan
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Arrhythmias, Ministry of Education of China, East Hospital, Shanghai, 200092, People's Republic of China.|Department of Anatomy and Neurobiology, Collaborative Innovation Center for Brain Science, Tongji University School of Medicine, Shanghai, 200092, People's Republic of China.|School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, Scotland, UK.
authors.forename: Michal
authors.initials: M
authors.lastname: Pruski
authors.affiliation: Key Laboratory of Arrhythmias, Ministry of Education of China, East Hospital, Shanghai, 200092, People's Republic of China.|Department of Anatomy and Neurobiology, Collaborative Innovation Center for Brain Science, Tongji University School of Medicine, Shanghai, 200092, People's Republic of China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Key Laboratory of Arrhythmias, Ministry of Education of China, East Hospital, Shanghai, 200092, People's Republic of China.|Department of Anatomy and Neurobiology, Collaborative Innovation Center for Brain Science, Tongji University School of Medicine, Shanghai, 200092, People's Republic of China.
authors.forename: Cong-Cong
authors.initials: CC
authors.lastname: Qi
authors.affiliation: Key Laboratory of Arrhythmias, Ministry of Education of China, East Hospital, Shanghai, 200092, People's Republic of China.|Department of Anatomy and Neurobiology, Collaborative Innovation Center for Brain Science, Tongji University School of Medicine, Shanghai, 200092, People's Republic of China.
authors.forename: Ning-Ning
authors.initials: NN
authors.lastname: Song
authors.affiliation: Key Laboratory of Arrhythmias, Ministry of Education of China, East Hospital, Shanghai, 200092, People's Republic of China.|Department of Anatomy and Neurobiology, Collaborative Innovation Center for Brain Science, Tongji University School of Medicine, Shanghai, 200092, People's Republic of China.|School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, Scotland, UK.
authors.forename: Bing
authors.initials: B
authors.lastname: Lang
authors.affiliation: Department of Histology and Embryology, Institute of Neuroscience, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, People's Republic of China. dingyuqiang@vip.163.com.|Key Laboratory of Arrhythmias, Ministry of Education of China, East Hospital, Shanghai, 200092, People's Republic of China. dingyuqiang@vip.163.com.|Department of Anatomy and Neurobiology, Collaborative Innovation Center for Brain Science, Tongji University School of Medicine, Shanghai, 200092, People's Republic of China. dingyuqiang@vip.163.com.
authors.forename: Yu-Qiang
authors.initials: YQ
authors.lastname: Ding
mesh_terms: D000818:Animals; D001007:Anxiety / Q000150:complications / Q000503:physiopathology; D001522:Behavior, Animal; D007031:Hypothalamus / Q000378:metabolism / Q000503:physiopathology; D018782:Maze Learning; D008569:Memory Disorders / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology*; D008810:Mice, Inbred C57BL; D009043:Motor Activity; D010121:Oxytocin / Q000008:administration & dosage / Q000378:metabolism* / Q000494:pharmacology; D012683:Sensory Deprivation; D012903:Smell; D012919:Social Behavior
chemical_list: D010121:Oxytocin
keywords: Autism; Infraorbital nerve; Oxytocin; Sensory deprivation; Social memory; Spatial memory