title: Positive variation of the MRI signal via intramolecular inclusion complexation of a C-2 functionalized β-cyclodextrin.
abstract: The synthesis of a new contrast agent based on a β-cyclodextrin scaffold and bearing a flexible lipophilic spacer arm on its secondary face is reported. Intermolecular host-guest inclusion complexes were known to undergo an enhancement of the contrast imaging. We extend this concept to intramolecular complexation. Inter- and intramolecular interactions are compared by NMR spectroscopy, circular dichroism and magnetic resonance imaging using hydrocinnamic acid and adamantane carboxylic acid as external guests. This positive variation of the observed relaxivity is a key element of new strategies aiming at developing smart molecular MRI probes.
authors.affiliation: Normandie Univ, COBRA, UMR 6014, FR 3038, INSA Rouen, CNRS, IRIB IRCOF 1 rue Tesnière, 76821 Mont-Saint-Aignan, France. geraldine.gouhier@univ-rouen.fr.
authors.forename: I
authors.initials: I
authors.lastname: Zgani
authors.affiliation: Normandie Univ, COBRA, UMR 6014, FR 3038, INSA Rouen, CNRS, IRIB IRCOF 1 rue Tesnière, 76821 Mont-Saint-Aignan, France. geraldine.gouhier@univ-rouen.fr and Lebanese International University, Biological and Chemical Sciences, P.O. Box 146404 Mazraa, Mousaytbeh, Beyrouth, Lebanon.
authors.forename: H
authors.initials: H
authors.lastname: Idriss
authors.affiliation: Normandie Univ, COBRA, UMR 6014, FR 3038, INSA Rouen, CNRS, IRIB IRCOF 1 rue Tesnière, 76821 Mont-Saint-Aignan, France. geraldine.gouhier@univ-rouen.fr.
authors.forename: C
authors.identifier: http://orcid.org/0000-0002-2385-440X
authors.initials: C
authors.lastname: Barbot
authors.affiliation: University of Picardie Jules Verne, LG2A UMR CNRS 7378, France.
authors.forename: F
authors.initials: F
authors.lastname: Djedaïni-Pilard
authors.affiliation: Normandie Univ, SMS, EA 3233, Place E. Blondel, 76821 Mont Saint Aignan Cedex, France.
authors.forename: S
authors.identifier: http://orcid.org/0000-0002-2319-7307
authors.initials: S
authors.lastname: Petit
authors.affiliation: Normandie Univ, COBRA, UMR 6014, FR 3038, INSA Rouen, CNRS, IRIB IRCOF 1 rue Tesnière, 76821 Mont-Saint-Aignan, France. geraldine.gouhier@univ-rouen.fr.
authors.forename: M
authors.initials: M
authors.lastname: Hubert-Roux
authors.affiliation: Normandie Univ, COBRA, UMR 6014, FR 3038, INSA Rouen, CNRS, IRIB IRCOF 1 rue Tesnière, 76821 Mont-Saint-Aignan, France. geraldine.gouhier@univ-rouen.fr.
authors.forename: F
authors.initials: F
authors.lastname: Estour
authors.affiliation: Normandie Univ, COBRA, UMR 6014, FR 3038, INSA Rouen, CNRS, IRIB IRCOF 1 rue Tesnière, 76821 Mont-Saint-Aignan, France. geraldine.gouhier@univ-rouen.fr.
authors.forename: G
authors.identifier: http://orcid.org/0000-0002-3852-1827
authors.initials: G
authors.lastname: Gouhier
mesh_terms: D008279:Magnetic Resonance Imaging; D008958:Models, Molecular; D015394:Molecular Structure; D047392:beta-Cyclodextrins / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D047392:beta-Cyclodextrins