title: Rats overexpressing the dopamine transporter display behavioral and neurobiological abnormalities with relevance to repetitive disorders.
abstract: The dopamine transporter (DAT) plays a pivotal role in maintaining optimal dopamine signaling. DAT-overactivity has been linked to various neuropsychiatric disorders yet so far the direct pathological consequences of it has not been fully assessed. We here generated a transgenic rat model that via pronuclear microinjection overexpresses the DAT gene. Our results demonstrate that DAT-overexpression induces multiple neurobiological effects that exceeded the expected alterations in the corticostriatal dopamine system. Furthermore, transgenic rats specifically exhibited behavioral and pharmaco-therapeutic profiles phenotypic of repetitive disorders. Together our findings suggest that the DAT rat model will constitute a valuable tool for further investigations into the pathological influence of DAT overexpression on neural systems relevant to neuropsychiatric disorders.
authors.affiliation: Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität, Dresden, Germany.
authors.forename: Ravit
authors.initials: R
authors.lastname: Hadar
authors.affiliation: Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität, Dresden, Germany.|International Graduate Program Medical Neurosciences, Charité Universitätsmedizin Berlin, Germany.
authors.forename: Henriette
authors.initials: H
authors.lastname: Edemann-Callesen
authors.affiliation: Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität, Dresden, Germany.
authors.forename: Claudia
authors.initials: C
authors.lastname: Reinel
authors.affiliation: Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität, Dresden, Germany.
authors.forename: Franziska
authors.initials: F
authors.lastname: Wieske
authors.affiliation: Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität, Dresden, Germany.|International Graduate Program Medical Neurosciences, Charité Universitätsmedizin Berlin, Germany.
authors.forename: Mareike
authors.initials: M
authors.lastname: Voget
authors.affiliation: Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.
authors.forename: Elena
authors.initials: E
authors.lastname: Popova
authors.affiliation: Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität, Dresden, Germany.
authors.forename: Reinhard
authors.initials: R
authors.lastname: Sohr
authors.affiliation: Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität, Dresden, Germany.
authors.forename: Yosef
authors.initials: Y
authors.lastname: Avchalumov
authors.affiliation: Department of Neuropsychiatry and Laboratory of Molecular Psychiatry, Charité Universitätsmedizin Berlin, Cluster of Excellence NeuroCure, BIH and DZNE, Berlin, Germany.
authors.forename: Josef
authors.initials: J
authors.lastname: Priller
authors.affiliation: Department of Neurology, Charité Universitätsmedizin Berlin, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: van Riesen
authors.affiliation: Klinik für Psychiatrie und Psychotherapie, Charité Universit, Berlin, Germany.
authors.forename: Imke
authors.initials: I
authors.lastname: Puls
authors.affiliation: Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.|Department of Endocrinology, Charité Universitätsmedizin Berlin, Germany.|Institute for Biology, University of Lübeck, Lübeck, Germany.|Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, Brazil.
authors.forename: Michael
authors.initials: M
authors.lastname: Bader
authors.affiliation: Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität, Dresden, Germany.
authors.forename: Christine
authors.initials: C
authors.lastname: Winter
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D050483:Dopamine Plasma Membrane Transport Proteins / Q000235:genetics*; D008297:Male; D051379:Mice; D008845:Microinjections; D009422:Nervous System Diseases / Q000235:genetics / Q000523:psychology*; D051381:Rats; D055647:Rats, Transgenic; D015854:Up-Regulation
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; C493215:Slc6a3 protein, mouse