title: Directed Zincation with TMPZnCl·LiCl and Further Functionalization of the Tropolone Scaffold.
abstract: The directed zincation of tropolone derivatives was achieved using TMPZnCl·LiCl. Various functionalizations of the zincated intermediates by halogenation, acylation, allylation, and Negishi cross-coupling were successfully performed. Additionally, 1,8-conjugate addition-elimination reactions with a variety of arylmagnesium and secondary alkylzinc reagents were carried out to further elaborate the tropolone core.
authors.affiliation: Department of Chemistry, Ludwig-Maximilians-University Munich , Butenandtstr. 5-13, 81377 Munich, Germany.
authors.forename: Diana
authors.initials: D
authors.lastname: Haas
authors.affiliation: Department of Chemistry, Ludwig-Maximilians-University Munich , Butenandtstr. 5-13, 81377 Munich, Germany.
authors.forename: Daniela
authors.initials: D
authors.lastname: Sustac-Roman
authors.affiliation: Department of Chemistry, Ludwig-Maximilians-University Munich , Butenandtstr. 5-13, 81377 Munich, Germany.
authors.forename: Sophia
authors.initials: S
authors.lastname: Schwarz
authors.affiliation: Department of Chemistry, Ludwig-Maximilians-University Munich , Butenandtstr. 5-13, 81377 Munich, Germany.
authors.forename: Paul
authors.identifier: 0000-0001-8167-272X
authors.initials: P
authors.lastname: Knochel