title: On-Demand Drug Delivery System Using Micro-organogels with Gold Nanorods.
abstract: In this study, we designed a biocompatible drug carrier: micro-organogels prepared by emulsification using vegetable oils and self-assembled gelator fibers. Flurbiprofen was chosen as a hydrophobic model drug and is classified as a nonsteroidal anti-inflammatory drug. In the absence of NIR light, flurbiprofen encapsulated in micro-organogels with gold nanorods (GNRs) was released slowly, while release was accelerated in the presence of NIR light due to the increase in the temperature surrounding the GNRs that transforms the gels into liquid. These results suggest that our system can be efficiently used as a versatile scaffold for on-demand drug delivery systems.
authors.affiliation: Department of Chemistry and Department of Pharmacy, Sahmyook University , Hwarangro 815, Nowon-gu, Seoul 01795, Republic of Korea.
authors.forename: Honglual
authors.initials: H
authors.lastname: Park
authors.affiliation: Department of Chemistry and Department of Pharmacy, Sahmyook University , Hwarangro 815, Nowon-gu, Seoul 01795, Republic of Korea.
authors.forename: Soojung
authors.initials: S
authors.lastname: Yang
authors.affiliation: Department of Chemistry and Department of Pharmacy, Sahmyook University , Hwarangro 815, Nowon-gu, Seoul 01795, Republic of Korea.
authors.forename: Jin Yang
authors.initials: JY
authors.lastname: Kang
authors.affiliation: Department of Chemistry and Department of Pharmacy, Sahmyook University , Hwarangro 815, Nowon-gu, Seoul 01795, Republic of Korea.
authors.forename: Myoung-Hwan
authors.initials: MH
authors.lastname: Park
keywords: Micro-organogels; flurbiprofen; gold nanorods; near-infrared; on-demand drug delivery