title: Single molecule based SNP detection using designed DNA carriers and solid-state nanopores.
abstract: Single nucleotide polymorphisms (SNPs) play a crucial role as molecular markers in medical and diagnostic application. We demonstrate a nanopore based method for SNP detection at the single molecule level. Designed DNA carriers are used to distinguish DNA strands containing only one single base difference and follow strand displacement kinetics.
authors.affiliation: Cavendish Laboratory, University of Cambridge, Cambridge, UK. ufk20@cam.ac.uk.
authors.forename: Jinglin
authors.identifier: 0000-0003-4549-0720
authors.initials: J
authors.lastname: Kong
authors.affiliation: Cavendish Laboratory, University of Cambridge, Cambridge, UK. ufk20@cam.ac.uk.
authors.forename: Jinbo
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Cavendish Laboratory, University of Cambridge, Cambridge, UK. ufk20@cam.ac.uk.
authors.forename: Ulrich F
authors.identifier: 0000-0003-3188-5414
authors.initials: UF
authors.lastname: Keyser
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D004247:DNA / Q000737:chemistry / Q000235:genetics*; D015342:DNA Probes / Q000737:chemistry; D007700:Kinetics; D008958:Models, Molecular; D058608:Nanopores; D036103:Nanotechnology; D009690:Nucleic Acid Conformation; D020641:Polymorphism, Single Nucleotide
chemical_list: D015342:DNA Probes; D004247:DNA