title: Back to the Roots: Deep View into the Evolutionary History of ADP-Ribosylation Opened by the DNA-Targeting Toxin-Antitoxin Module DarTG.
abstract: In this issue of Molecular Cell, Jankevicius et al. (2016) characterize the DarTG toxin-antitoxin module in which the DarT toxin ADP-ribosylates single-stranded DNA and the DarG antitoxin counteracts DarT by direct binding and by enzymatic removal of the ADP-ribosylation.
authors.affiliation: Center of Excellence for Bacterial Stress Response and Persistence, Department of Biology, University of Copenhagen, 2200 Copenhagen N, Denmark.
authors.forename: Alexander
authors.initials: A
authors.lastname: Harms
authors.affiliation: Center of Excellence for Bacterial Stress Response and Persistence, Department of Biology, University of Copenhagen, 2200 Copenhagen N, Denmark. Electronic address: kgerdes@bio.ku.dk.
authors.forename: Kenn
authors.initials: K
authors.lastname: Gerdes
mesh_terms: D000244:Adenosine Diphosphate; D000246:Adenosine Diphosphate Ribose; D037361:Adenylate Cyclase Toxin; D000992:Antitoxins; D004247:DNA; D004277:DNA, Single-Stranded; D006801:Humans
chemical_list: D037361:Adenylate Cyclase Toxin; D000992:Antitoxins; D004277:DNA, Single-Stranded; D000246:Adenosine Diphosphate Ribose; D000244:Adenosine Diphosphate; D004247:DNA
keywords: ADP-ribosylation; DarG; DarT; bacterial persistence; restriction-modification system; toxin-antitoxin module