title: Cell Division: Flipping the Mitotic Switches.
abstract: Alternation between DNA replication in the mother cell (S phase) and equal partitioning of the replicated chromosomes to the daughter cells (M phase) during eukaryotic cell division is governed by switches that flip protein kinases on and off. New work reveals that the M-phase promoting kinase is opposed by a phosphatase that also participates in a bistable switching mechanism.
authors.affiliation: Max-Planck-Institute of Biochemistry, Martinsried, Germany. Electronic address: zachar@biochem.mpg.de.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Zachariae
authors.affiliation: Department of Biological Sciences, Virginia Tech, Blacksburg, VA, USA. Electronic address: tyson@vt.edu.
authors.forename: John J
authors.initials: JJ
authors.lastname: Tyson
mesh_terms: D000818:Animals; D002455:Cell Division / Q000502:physiology*; D002875:Chromosomes / Q000502:physiology*; D004261:DNA Replication; D005057:Eukaryotic Cells; D015971:Gene Expression Regulation, Enzymologic / Q000502:physiology*; D011494:Protein Kinases / Q000235:genetics / Q000378:metabolism*; D016196:S Phase / Q000502:physiology*
chemical_list: D011494:Protein Kinases