title: Effects of ibrutinib treatment on murine platelet function during inflammation and in primary hemostasis.
authors.affiliation: McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
authors.forename: Robert H
authors.initials: RH
authors.lastname: Lee
authors.affiliation: McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
authors.forename: Raymond
authors.initials: R
authors.lastname: Piatt
authors.affiliation: Portola Pharmaceuticals, South San Francisco, CA, USA.
authors.forename: Pamela B
authors.initials: PB
authors.lastname: Conley
authors.affiliation: McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA bergmeie@email.unc.edu.|Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, NC, USA.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Bergmeier
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives; D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D001792:Blood Platelets / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D003094:Collagen / Q000494:pharmacology; D003435:Crotalid Venoms / Q000494:pharmacology; D005786:Gene Expression Regulation; D006470:Hemorrhage / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D006487:Hemostasis / Q000187:drug effects*; D007249:Inflammation / Q000517:prevention & control; D037181:Lectins, C-Type / Q000235:genetics / Q000378:metabolism; D008070:Lipopolysaccharides / Q000494:pharmacology; D008168:Lung / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008562:Membrane Glycoproteins / Q000494:pharmacology; D051379:Mice; D009842:Oligopeptides / Q000494:pharmacology; D010880:Piperidines; D010974:Platelet Aggregation / Q000187:drug effects*; D010980:Platelet Membrane Glycoproteins / Q000819:agonists / Q000235:genetics / Q000378:metabolism; D047428:Protein Kinase Inhibitors / Q000494:pharmacology*; D011720:Pyrazoles / Q000494:pharmacology*; D011743:Pyrimidines / Q000494:pharmacology*; D058925:Receptors, Purinergic P2Y12 / Q000172:deficiency / Q000235:genetics / Q000378:metabolism; D012867:Skin / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D000098853:Podoplanin
chemical_list: D000225:Adenine; D000244:Adenosine Diphosphate; D003094:Collagen; D003435:Crotalid Venoms; D037181:Lectins, C-Type; D008070:Lipopolysaccharides; D008562:Membrane Glycoproteins; D009842:Oligopeptides; D010880:Piperidines; D010980:Platelet Membrane Glycoproteins; D047428:Protein Kinase Inhibitors; D011720:Pyrazoles; D011743:Pyrimidines; D058925:Receptors, Purinergic P2Y12; C529518:CLEC-2 protein, mouse; C490441:Pdpn protein, mouse; D000098853:Podoplanin; C548577:P2ry12 protein, mouse; C455901:alanyl-tyrosyl-prolyl-glycyl-lysyl-phenylalanine; C098341:platelet membrane glycoprotein VI; C551803:ibrutinib; C028890:convulxin