title: Synthesis and antimicrobial evaluation of novel analogues of dehydroabietic acid prepared by CH-Activation.
abstract: Dehydroabietic acid (DHAA) plays an important role in drug discovery. Its modification at chemically reactive positions has been exploited to a large extent over the last decades, generating a wide range of analogues. In contrast, introduction of substituents at chemically inert positions remains a sizeable challenge. Hereby we wish to report the synthesis of a first series of C-19-arylated DHAA-analogues by application of a simple CH activation protocol, as well as their antimicrobial activity against methicillin resistant Staphylococcus aureus (MRSA).
authors.affiliation: Institute of Organic Chemistry, University of Vienna, Währinger Straße 38, 1090 Vienna, Austria.
authors.forename: Martin
authors.initials: M
authors.lastname: Berger
authors.affiliation: Center of X-ray Structure Analysis, University of Vienna, Währinger Straße 42, 1090 Vienna, Austria.
authors.forename: Alexander
authors.initials: A
authors.lastname: Roller
authors.affiliation: Institute of Organic Chemistry, University of Vienna, Währinger Straße 38, 1090 Vienna, Austria. Electronic address: nuno.maulide@univie.ac.at.
authors.forename: Nuno
authors.initials: N
authors.lastname: Maulide
mesh_terms: D045784:Abietanes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D060326:Chemistry Techniques, Synthetic; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects
chemical_list: D045784:Abietanes; D000900:Anti-Bacterial Agents; C013913:dehydroabietic acid
keywords: Antimicrobial; CH-activation; Dehydroabietic acid; Directing group; MRSA