title: Silkworm Sericin: Properties and Biomedical Applications.
abstract: Silk sericin is a natural polymer produced by silkworm,Bombyx mori, which surrounds and keeps together two fibroin filaments in silk thread used in the cocoon. The recovery and reuse of sericin usually discarded by the textile industry not only minimizes environmental issues but also has a high scientific and commercial value. The physicochemical properties of the molecule are responsible for numerous applications in biomedicine and are influenced by the extraction method and silkworm lineage, which can lead to variations in molecular weight and amino acid concentration of sericin. The presence of highly hydrophobic amino acids and its antioxidant potential make it possible for sericin to be applied in the food and cosmetic industry. The moisturizing power allows indications as a therapeutic agent for wound healing, stimulating cell proliferation, protection against ultraviolet radiation, and formulating creams and shampoos. The antioxidant activity associated with low digestibility of sericin that expands the application in the medical field, such as antitumour, antimicrobial and anti-inflammatory agent, anticoagulant, acts in colon health, improving constipation and protects the body from obesity through improved plasma lipid profile. In addition, the properties of sericin allow its application as a culture medium and cryopreservation, in tissue engineering and for drug delivery, demonstrating its effective use, as an important biomaterial.
authors.affiliation: Department of Morphological Sciences, State University of Maringá, Av. Colombo, 5790, 87020-900 Maringá, PR, Brazil.
authors.forename: Regina Inês
authors.identifier: 0000-0003-1510-7022
authors.initials: RI
authors.lastname: Kunz
authors.affiliation: Center of Biological Sciences and Health, State University of Western Paraná, Rua Universitária, 2069, 85819-110 Cascavel, PR, Brazil.
authors.forename: Rose Meire Costa
authors.identifier: 0000-0002-5344-5076
authors.initials: RM
authors.lastname: Brancalhão
authors.affiliation: Center of Biological Sciences and Health, State University of Western Paraná, Rua Universitária, 2069, 85819-110 Cascavel, PR, Brazil.
authors.forename: Lucinéia de Fátima Chasko
authors.initials: LF
authors.lastname: Ribeiro
authors.affiliation: Department of Morphological Sciences, State University of Maringá, Av. Colombo, 5790, 87020-900 Maringá, PR, Brazil.
authors.forename: Maria Raquel Marçal
authors.identifier: 0000-0002-7486-2581
authors.initials: MR
authors.lastname: Natali
mesh_terms: D000825:Animal Structures / Q000033:anatomy & histology; D000818:Animals; D020811:Biomedical Technology / Q000379:methods*; D012831:Bombyx / Q000737:chemistry*; D016503:Drug Delivery Systems; D006801:Humans; D047030:Sericins / Q000096:biosynthesis / Q000378:metabolism*; D023822:Tissue Engineering
chemical_list: D047030:Sericins