title: A General Method for Selective Recognition of Monosaccharides and Oligosaccharides in Water.
abstract: Molecular recognition of carbohydrates plays vital roles in biology but has been difficult to achieve with synthetic receptors. Through covalent imprinting of carbohydrates in boroxole-functionalized cross-linked micelles, we prepared nanoparticle receptors for a wide variety of mono- and oligosaccharides. The boroxole functional monomer bound the sugar templates through cis-1,2-diol, cis-3,4-diol, and trans-4,6-diol. The protein-sized nanoparticles showed excellent selectivity for d-aldohexoses in water with submillimolar binding affinities and completely distinguished the three biologically important hexoses (glucose, mannose, and galactose). Glycosides with nonpolar aglycon showed stronger binding due to enhanced hydrophobic interactions. Oligosaccharides were distinguished on the basis of their monosaccharide building blocks, glycosidic linkages, chain length, as well as additional functional groups that could interact with the nanoparticles.
authors.affiliation: Department of Chemistry, Iowa State University , Ames, Iowa 50011-3111, United States.
authors.forename: Roshan W
authors.initials: RW
authors.lastname: Gunasekara
authors.affiliation: Department of Chemistry, Iowa State University , Ames, Iowa 50011-3111, United States.
authors.forename: Yan
authors.identifier: 0000-0003-1215-2565
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D006601:Hexoses / Q000737:chemistry; D054802:Molecular Imprinting; D015394:Molecular Structure; D009005:Monosaccharides / Q000737:chemistry*; D053758:Nanoparticles; D009844:Oligosaccharides / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
chemical_list: D006601:Hexoses; D009005:Monosaccharides; D009844:Oligosaccharides; D014867:Water