title: Tracking the formation of supramolecular G-quadruplexes via self-assembly enhanced emission.
abstract: We report the synthesis and self-assembly of two lipophilic 2'-deoxyguanosine (G) derivatives whose fluorescence intensity is modulated by self-assembly into supramolecular G-quadruplexes (SGQs). Whereas both derivatives self-assemble isostructurally, one shows up to 100% emission enhancement while the other shows an initial enhancement, followed by 10% quenching. Thus, the rotational restrictions resulting from self-assembly are enough to induce significant changes in emission, but it is critical to consider the specific interactions between fluorophores since they will determine the ultimate emission signature. These findings could open the door to the development of luminescent supramolecular sensors and probes.
authors.affiliation: Department of Chemistry and Molecular Sciences Research Center, University of Puerto Rico at Río Piedras, San Juan, 00926, Puerto Rico. riveralab.upr@gmail.com.
authors.forename: Diana
authors.initials: D
authors.lastname: Silva-Brenes
authors.affiliation: Department of Chemistry and Molecular Sciences Research Center, University of Puerto Rico at Río Piedras, San Juan, 00926, Puerto Rico. riveralab.upr@gmail.com.
authors.forename: Loruhama
authors.initials: L
authors.lastname: Delgado
authors.affiliation: Department of Chemistry and Molecular Sciences Research Center, University of Puerto Rico at Río Piedras, San Juan, 00926, Puerto Rico. riveralab.upr@gmail.com.
authors.forename: José M
authors.identifier: http://orcid.org/0000-0001-7089-7640
authors.initials: JM
authors.lastname: Rivera
mesh_terms: D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry; D005453:Fluorescence; D054856:G-Quadruplexes; D046911:Macromolecular Substances / Q000138:chemical synthesis / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure
chemical_list: D046911:Macromolecular Substances; D003849:Deoxyguanosine