title: Role of LRV1 and RNAi in the Pathogenesis of Leishmania.
abstract: The recent paper by Brettmann et al. provides insight as to how an RNA virus can persistently coexist in a protozoan with RNAi activity and how these two entities work to maintain balance. The authors were also able to successfully remove the virus and examine the role of the virus in parasitemia and the pathogenesis of leishmaniasis.
authors.affiliation: Department of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, TX 78227,USA. Electronic address: jpatters@TxBiomed.org.
authors.forename: Jean L
authors.initials: JL
authors.lastname: Patterson
mesh_terms: D000818:Animals; D006801:Humans; D007891:Leishmania / Q000235:genetics / Q000821:virology*; D007896:Leishmaniasis / Q000235:genetics / Q000469:parasitology* / Q000503:physiopathology / Q000821:virology*; D018512:Parasitemia / Q000469:parasitology / Q000503:physiopathology* / Q000821:virology*; D034622:RNA Interference; D012328:RNA Viruses / Q000502:physiology*
keywords: LRV1; RNAi