title: The CD24 surface antigen in neural development and disease.
abstract: A cell's surface molecular signature enables its reciprocal interactions with the associated microenvironments in development, tissue homeostasis and pathological processes. The CD24 surface antigen (heat-stable antigen, nectadrin; small cell lung cancer antigen cluster-4) represents a prime example of a neural surface molecule that has long been known, but whose diverse molecular functions in intercellular communication we have only begun to unravel. Here, we briefly summarize the molecular fundamentals of CD24 structure and provide a comprehensive review of CD24 expression and functional studies in mammalian neural developmental systems and disease models (rodent, human). Striving for an integrated view of the intracellular signaling processes involved, we discuss the most pertinent routes of CD24-mediated signaling pathways and functional networks in neurobiology (neural migration, neurite extension, neurogenesis) and pathology (tumorigenesis, multiple sclerosis).
authors.affiliation: Emmy Noether-Group for Stem Cell Biology, Department of Molecular Embryology, Institute of Anatomy and Cell Biology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
authors.forename: Daniel T
authors.initials: DT
authors.lastname: Gilliam
authors.affiliation: Emmy Noether-Group for Stem Cell Biology, Department of Molecular Embryology, Institute of Anatomy and Cell Biology, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Spemann Graduate School of Biology and Medicine and Faculty of Biology, University of Freiburg, Freiburg, Germany.
authors.forename: Vishal
authors.initials: V
authors.lastname: Menon
authors.affiliation: Department of Medicine, Division of Hematology, Harvard Medical School, Brigham & Women's Hospital, Boston, MA, USA.
authors.forename: Niko P
authors.initials: NP
authors.lastname: Bretz
authors.affiliation: Emmy Noether-Group for Stem Cell Biology, Department of Molecular Embryology, Institute of Anatomy and Cell Biology, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Center for Biological Signaling Studies (BIOSS), University of Freiburg, Freiburg, Germany; Institute for Cell and Gene Therapy, University Medical Center Freiburg, Freiburg, Germany. Electronic address: jan.pruszak@uniklinik-freiburg.de.
authors.forename: Jan
authors.initials: J
authors.lastname: Pruszak
mesh_terms: D000818:Animals; D051927:CD24 Antigen / Q000378:metabolism*; D006801:Humans; D009420:Nervous System / Q000254:growth & development / Q000378:metabolism; D009422:Nervous System Diseases / Q000378:metabolism; D009474:Neurons / Q000378:metabolism*
chemical_list: D051927:CD24 Antigen
keywords: Autoimmune; CD molecule; CD24; Cancer; Cell signaling; Cluster of differentiation; Development; Heat stable antigen; Nectadrin; Neurobiology; Small cell lung cancer antigen cluster-4