title: Effectiveness of Teriparatide on Fracture Healing: A Systematic Review and Meta-Analysis.
abstract: OBJECTIVE
  Nowadays, the efficacy of teriparatide in treating osteoporosis was widely accepted, but the discussion about using teriparatide to enhance fracture healing hasn't come to an agreement. This meta-analysis was conducted to evaluate the effectiveness of teriparatide for fracture healing.
  
  
  METHODS
  We searched PubMed, the Cochrane Library, and Embase in August 2016 for randomized controlled trials (RCTs) which concerned the treatment of teriparatide for fracture healing.
  
  
  RESULTS
  Finally, a total of 380 patients were randomly assigned in the 5 trials included in this meta-analysis. There was a significant effectiveness with regards to function improvement in patients following fracture, however, there was no significant effectiveness with regards to time of radiographic fracture healing, fracture healing rate and reduction in pain.
  
  
  CONCLUSIONS
  This analysis showed that administration of teriparatide following fracture lacked the effectiveness for fracture healing. Moreover, teriparatide administration had no apparent adverse effects. These results should be interpreted with caution because of some clear limitations. If we want to confirm whether teriparatide improves fracture healing, more high-quality randomized controlled trials are needed.
authors.affiliation: Department of Orthopaedics, Tianjin Medical University General Hospital, Tianjin, PR China.
authors.forename: Zhongju
authors.initials: Z
authors.lastname: Shi
authors.affiliation: Department of Orthopaedics, Tianjin Medical University General Hospital, Tianjin, PR China.
authors.forename: Hengxing
authors.initials: H
authors.lastname: Zhou
authors.affiliation: Department of Orthopaedics, Tianjin Medical University General Hospital, Tianjin, PR China.
authors.forename: Bin
authors.initials: B
authors.lastname: Pan
authors.affiliation: Department of Orthopaedics, Tianjin Medical University General Hospital, Tianjin, PR China.
authors.forename: Lu
authors.initials: L
authors.lastname: Lu
authors.affiliation: Department of Orthopaedics, Tianjin Medical University General Hospital, Tianjin, PR China.
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Orthopaedics, Tianjin Medical University General Hospital, Tianjin, PR China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Kang
authors.affiliation: Department of Orthopaedics, Tianjin Medical University General Hospital, Tianjin, PR China.
authors.forename: Xue
authors.initials: X
authors.lastname: Yao
authors.affiliation: Department of Orthopaedics, Tianjin Medical University General Hospital, Tianjin, PR China.
authors.forename: Shiqing
authors.initials: S
authors.lastname: Feng
mesh_terms: D005260:Female; D017102:Fracture Healing / Q000187:drug effects*; D006801:Humans; D008297:Male; D010146:Pain / Q000188:drug therapy*; D016032:Randomized Controlled Trials as Topic; D019379:Teriparatide / Q000627:therapeutic use*
chemical_list: D019379:Teriparatide