title: National Institutes of Health Hematopoietic Cell Transplantation Late Effects Initiative: Developing Recommendations to Improve Survivorship and Long-Term Outcomes.
abstract: Continual advances in hematopoietic cell transplantation (HCT) have greatly improved early transplantation-related mortality and broadened the applicability of this intense but curative therapy. With growing success there is increasing awareness of late complications, occurring ≥1 year after treatment, and their associated morbidity and mortality in HCT survivors. These late effects occur with a wide spectrum in terms of latency, intensity, reversibility, and lethality. There is a need to understand the biology, surveillance, management, and patient experience of HCT-related effects, as well as the health care and research infrastructure to manage this growing population. To address these needs, the National Cancer Institute and National Heart, Lung and Blood Institute cosponsored a 12-month initiative to identify barriers and knowledge gaps and to formulate research and practice recommendations. Six major areas of interest were identified: research methodology and study design, subsequent neoplasms, patient-centered outcomes, immune dysregulation and pathobiology, cardiovascular disease and associated risk factors, and health care delivery. These findings were presented during the 2016 workshop and revised based on public response. This report provides an overview of the National Institutes of Health HCT Late Effects Initiative process and recommendations.
authors.affiliation: Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland. Electronic address: battiwam@nhlbi.nih.gov.
authors.forename: Minoo
authors.initials: M
authors.lastname: Battiwalla
authors.affiliation: Mayo Clinic Transplant Center, Mayo Clinic, Rochester, Minnesota.
authors.forename: Shahrukh
authors.initials: S
authors.lastname: Hashmi
authors.affiliation: Blood and Marrow Transplant Program, Cleveland Clinic, Cleveland, Ohio.
authors.forename: Navneet
authors.initials: N
authors.lastname: Majhail
authors.affiliation: Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
authors.forename: Steven
authors.initials: S
authors.lastname: Pavletic
authors.affiliation: Hematology & Stem Cell Transplantation Section, Vanderbilt University Medical Center, Nashville, Tennessee.
authors.forename: Bipin N
authors.initials: BN
authors.lastname: Savani
authors.affiliation: Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Rockville, Maryland.
authors.forename: Nonniekaye
authors.initials: N
authors.lastname: Shelburne
mesh_terms: D003695:Delivery of Health Care; D006287:Health Planning Guidelines; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods / Q000639:trends; D006801:Humans; D000069451:Long Term Adverse Effects; D054547:National Cancer Institute (U.S.); D054555:National Heart, Lung, and Blood Institute (U.S.); D009316:National Institutes of Health (U.S.); D012107:Research Design; D013997:Time Factors; D014481:United States
keywords: Hematopoietic cell transplantation; Late effects; Survivorship