title: Hodgkin's Lymphoma - evaluation of patients submitted to Autologous transplantation of hematopoietic cells in the Hematology Service of the Hospital Walter Cantídio - Fortaleza, Brazil.
abstract: The Autologous HSCT is an important alternative for refractory or recurrent HL patients in terms of survival and improved quality of life. This study analyzes the results of autologous BMT performed in HL patients in the Transplant Unit of the HUWC/ HEMOCE (Fortaleza - CE, Brazil). Fifty-two transplanted patients were studied from January 2009 to October 2015, among them, 30 men and 22 women, mean age of 28.2 years. All of them received GCS-F during the mobilization, in some cases associated with Vinorelbine or Plerixafor, with CD34 collection averaging 4.8 CD34/kg. The conditioning was performed with BEAC, NEAM or BEAM and the grafting with an average of 10 days. The evaluation on D + 100 showed: CR - 42 (82.7%), PR - 08 (13.5%) and 02 (3.8%) deaths, three and six days after cell infusion. After the D+100, 08 patients in CR showed HL recurrence from 06 to 36 months; 03 died and 05 are being treated with brentuximab; among the 08 patients in PR, 01 died due to HL activity, 04 months after BMT and 07 patients are undergoing treatment. The final evaluation of HL transplant patients showed an OS of 88.5% and a DFS of 61.5% in 6 years, with OS of the chemosensitive patients of 81% and of the chemoresistant ones, of 72.6%. It is possible to conclude that the Autologous HSCT has shown to be an excellent rescue therapy regarding tolerance, as well as the overall survival.
authors.affiliation: Service of Hematology, Bone-Marrow Transplant Unit and Cord Blood Bank, Brazil.
authors.forename: Fernando Barroso
authors.initials: FB
authors.lastname: Duarte
authors.affiliation: SH/HUWC, Brazil.
authors.forename: Mabel Gomes de Brito
authors.initials: MG
authors.lastname: Fernandes
authors.affiliation: Bone-Marrow Transplant Unit, Brazil.
authors.forename: Jacques
authors.initials: J
authors.lastname: Kaufmann
authors.affiliation: Bone-Marrow Transplant Unit, Brazil.
authors.forename: Karine Sampaio Nunes
authors.initials: KS
authors.lastname: Barroso
authors.affiliation: Bone-Marrow Transplant Unit, Brazil.
authors.forename: João Paulo de Vasconcelos
authors.initials: JP
authors.lastname: Leitão
authors.affiliation: Bone-Marrow Transplant Unit, Brazil.
authors.forename: Beatriz Stela Gomes de Souza Pitombeira
authors.initials: BS
authors.lastname: Araujo
authors.affiliation: Department of Internal Medicine, Faculdade de Medicina da UFC, Brazil.
authors.forename: Clara Maria Bastos Eloy da
authors.initials: CM
authors.lastname: Costa
authors.affiliation: SH/HUWC, Brazil.
authors.forename: Acy Teles
authors.initials: AT
authors.lastname: Quixadá-Medica
authors.affiliation: SH/HUWC, Brazil.
authors.forename: Jacqueline de Souza
authors.initials: JS
authors.lastname: Holanda
authors.affiliation: aff06, Brazil.
authors.forename: Samuel Vasconcelos
authors.initials: SV
authors.lastname: Landim
authors.affiliation: Department of Internal Medicine, Faculdade de Medicina da UFC, Brazil.
authors.forename: Maria Helena
authors.initials: MH
authors.lastname: Pitombeira
mesh_terms: D000293:Adolescent; D000328:Adult; D001938:Brazil; D018572:Disease-Free Survival; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods* / Q000401:mortality; D006689:Hodgkin Disease / Q000401:mortality / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D019172:Transplantation Conditioning / Q000379:methods; D014182:Transplantation, Autologous / Q000379:methods; D016896:Treatment Outcome; D055815:Young Adult