title: Management of cardiovascular disease in aging persons with haemophilia.
abstract: With the aging of the haemophilia population, age related comorbidities become more and more a medical issue. Managing haemophilia patients with cardiovascular disease is a difficult task for many haemophilia-treating physicians. Over the years, insights on prevalence, risk factors and management of cardiovascular disease in haemophilia have improved substantially. It is now recognised that many risk factors, such as hypertension and overweight, occur quite frequently in patients with haemophilia. Several new insights in anticoagulation management of atrial fibrillation and coronary ischaemia in haemophilia have been suggested. This review provides an general overview of the current knowledge of these topics in literature.
authors.affiliation: Roger E. G. Schutgens, MD, PhD, MSc, Van Creveldkliniek, UMC Utrecht, Heidelberglaan 100 3584CX Utrecht, The Netherlands, Tel: +31 88 7558450, r.schutgens@umcutrecht.nl.
authors.forename: Roger E G
authors.initials: REG
authors.lastname: Schutgens
authors.forename: Michiel
authors.initials: M
authors.lastname: Voskuil
authors.forename: Evelien P
authors.initials: EP
authors.lastname: Mauser-Bunschoten
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000009:adverse effects / Q000627:therapeutic use; D001281:Atrial Fibrillation / Q000097:blood / Q000150:complications / Q000453:epidemiology / Q000628:therapy; D002318:Cardiovascular Diseases / Q000097:blood / Q000150:complications* / Q000453:epidemiology / Q000628:therapy*; D015897:Comorbidity; D003324:Coronary Artery Disease / Q000097:blood / Q000150:complications / Q000453:epidemiology / Q000628:therapy; D003430:Cross-Sectional Studies; D005164:Factor IX / Q000378:metabolism; D005169:Factor VIII / Q000378:metabolism; D006467:Hemophilia A / Q000097:blood / Q000150:complications* / Q000453:epidemiology / Q000628:therapy*; D006801:Humans; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000150:complications / Q000453:epidemiology / Q000628:therapy; D012307:Risk Factors
chemical_list: D000925:Anticoagulants; C078147:F8 protein, human; D005169:Factor VIII; D005164:Factor IX
keywords: anticoagulation; cardiovascular; haemophilia