title: Evaluation of the biochemical, inflammatory and oxidative profile of obese patients given clinical treatment and bariatric surgery.
abstract: BACKGROUND
  We investigated the biochemical and inflammatory parameters as well as biomarkers of oxidative stress in morbidly obese patients before and after bariatric surgery and clinical treatment.
  
  
  METHODS
  This study was conducted using 60 individuals (10 men and 50 women) distributed into 3 groups: the control group, 20 non-diabetic obese patients given clinical treatment, the bariatric group, 20 non-diabetic obese patients given a Roux-en-Y bypass gastroplasty, and the bariatric diabetic group, 20 diabetic obese patients given a Roux-en-Y bypass gastroplasty. Measurements were made before and 1, 3, 6, and 12months after surgery and clinical treatment.
  
  
  RESULTS
  We showed a significant decrease in body weight, body mass index (BMI) and waist circumference, accompanied by a decrease in the lipid profile and glucose and glycated hemoglobin concentrations in the groups that received bariatric surgery. The concentrations of lipid peroxidation, carbonyl protein and NPSH, as well as superoxide dismutase (SOD) and catalase (CAT) activity, significantly decreased in both groups after surgery. The concentrations of inteleukin-6, inteleukin-1, TNF-α and resistin were also significantly lower, while adiponectin concentrations significantly increased 12months after bariatric surgery. No significant alterations were observed in the biochemical, inflammatory or oxidative parameters of the control group.
  
  
  CONCLUSIONS
  Our findings demonstrate a decrease in body mass and a subsequent improvement in biochemical, metabolic and anthropometric parameters in patients given bariatric surgery. This may contribute to the reduction of oxidative damage in these patients and consequently a reduction in the risk of the development and progression of multiple co-morbidities associated with obesity.
authors.affiliation: Programa de Pós Graduação em Bioquímica Toxicológica, Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, UFSM-RS, Brazil; Instituto Federal de Educação, Ciência e Tecnologia do Rio Grande do Sul, IFRS-Campus Ibirubá, RS, Brazil. Electronic address: betaschmatz@hotmail.com.
authors.forename: Roberta
authors.initials: R
authors.lastname: Schmatz
authors.affiliation: Hospital Universitário de Santa Maria, HUSM, Universidade Federal de Santa Maria, UFSM-RS, Brazil.
authors.forename: Mariana R
authors.initials: MR
authors.lastname: Bitencourt
authors.affiliation: Hospital Universitário de Santa Maria, HUSM, Universidade Federal de Santa Maria, UFSM-RS, Brazil.
authors.forename: Luciana D
authors.initials: LD
authors.lastname: Patias
authors.affiliation: Hospital Universitário de Santa Maria, HUSM, Universidade Federal de Santa Maria, UFSM-RS, Brazil.
authors.forename: Maristela
authors.initials: M
authors.lastname: Beck
authors.affiliation: Hospital Universitário de Santa Maria, HUSM, Universidade Federal de Santa Maria, UFSM-RS, Brazil.
authors.forename: Glauco
authors.initials: G
authors.lastname: da C Alvarez
authors.affiliation: Programa de Pós Graduação em Bioquímica Toxicológica, Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, UFSM-RS, Brazil.
authors.forename: Daniela
authors.initials: D
authors.lastname: Zanini
authors.affiliation: Programa de Pós Graduação em Bioquímica Toxicológica, Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, UFSM-RS, Brazil.
authors.forename: Jessié M
authors.initials: JM
authors.lastname: Gutierres
authors.affiliation: Hospital Universitário de Santa Maria, HUSM, Universidade Federal de Santa Maria, UFSM-RS, Brazil.
authors.forename: Lia Natália
authors.initials: LN
authors.lastname: Diehl
authors.affiliation: Programa de Pós Graduação em Bioquímica Toxicológica, Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, UFSM-RS, Brazil.
authors.forename: Luciane B
authors.initials: LB
authors.lastname: Pereira
authors.affiliation: Programa de Pós Graduação em Bioquímica Toxicológica, Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, UFSM-RS, Brazil.
authors.forename: Claudio Alberto
authors.initials: CA
authors.lastname: Leal
authors.affiliation: Programa de Pós Graduação em Bioquímica Toxicológica, Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, UFSM-RS, Brazil.
authors.forename: Marta Frescura
authors.initials: MF
authors.lastname: Duarte
authors.affiliation: Programa de Pós Graduação em Bioquímica Toxicológica, Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, UFSM-RS, Brazil.
authors.forename: Maria Rosa
authors.initials: MR
authors.lastname: Schetinger
authors.affiliation: Programa de Pós Graduação em Bioquímica Toxicológica, Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, UFSM-RS, Brazil.
authors.forename: Vera Maria
authors.initials: VM
authors.lastname: Morsch
mesh_terms: D000328:Adult; D002374:Catalase / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D016207:Cytokines / Q000097:blood; D003920:Diabetes Mellitus / Q000209:etiology / Q000378:metabolism / Q000601:surgery; D005260:Female; D015390:Gastric Bypass / Q000379:methods*; D006801:Humans; D007249:Inflammation / Q000378:metabolism* / Q000601:surgery; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000150:complications / Q000378:metabolism* / Q000601:surgery / Q000628:therapy*; D018384:Oxidative Stress; D013482:Superoxide Dismutase / Q000097:blood; D016896:Treatment Outcome
chemical_list: D008076:Cholesterol, HDL; D016207:Cytokines; D002374:Catalase; D013482:Superoxide Dismutase
keywords: Bariatric surgery; Clinical treatment; Inflammatory; Metabolism; Morbid obesity; Oxidative stress