title: The effect of three-dimensional conformal radiotherapy on locally recurrent nasopharyngeal carcinoma and on the expression of succinate dehydrogenase B.
abstract: Investigate the effect of three-dimensional conformal radiotherapy (3DCRT) on locally recurrent nasopharyngeal carcinoma (NPC) on the expression of succinate dehydrogenase B (SDHB).
  
  
  
  Eighty-six patients diagnosed with locally recurrent NPC in our hospital were selected and divided into the control group (43 cases) and observation group (43 cases). Conventional two-dimensional radiotherapy was applied in the control group, and 3DCRT was adopted in the observation group. The curative effect of both groups was compared.
  
  
  
  The effective rate and the degree of alleviation of the observation group were higher than those of the control group, and the differences were statistically significant (p<0.05). There were no differences in the occurrence rate of complications from radiotherapy between the two groups (p>0.05). The survival rate and median survival time of the observation group were significantly higher than those of the control group (p<0.05). The positive expression rate of SDHB in the observation group after radiotherapy was significantly higher than that of the control group (p<0.05), and the median survival time of patients with positive expression of SDHB was significantly higher than patients with negative expression (p<0.05).
  
  
  
  3DCRT applied for treatment of locally recurrent NPC was safe and effective. It also improved the positive expression rate of SDHB, which was associated with increased survival time.
authors.affiliation: Department of Otolaryngology, Ji'ning First People's Hospital of Shandong Province, Shandong, China. aynur.ersahin@hotmail.com.
authors.forename: C-X
authors.initials: CX
authors.lastname: Liu
authors.forename: H
authors.initials: H
authors.lastname: Wang
authors.forename: X-M
authors.initials: XM
authors.lastname: Qian
authors.forename: F-X
authors.initials: FX
authors.lastname: Lu
authors.forename: S-F
authors.initials: SF
authors.lastname: Zhuang
authors.forename: M-X
authors.initials: MX
authors.lastname: Yang
authors.forename: F-L
authors.initials: FL
authors.lastname: Wang
authors.forename: Y-T
authors.initials: YT
authors.lastname: Wang
mesh_terms: D002277:Carcinoma / Q000628:therapy*; D016022:Case-Control Studies; D006801:Humans; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000628:therapy*; D020266:Radiotherapy, Conformal; D013385:Succinate Dehydrogenase / Q000187:drug effects* / Q000378:metabolism; D015996:Survival Rate
chemical_list: C491545:SDHD protein, human; D013385:Succinate Dehydrogenase