title: Ribosome Assembly in Trypanosomatids: A Novel Therapeutic Target.
abstract: In Liu et al., the authors present a 2.5-Å structure of the Trypanosoma cruzi 60S ribosomal subunit and propose a model for the stepwise assembly of the large-subunit ribosomal RNA (rRNA). Based on this study, we discuss how the unique features of trypanosomatid ribosome assembly offer potential drug targets.
authors.affiliation: Department of Microbiology and Immunology and Witebsky Center for Microbial Pathogenesis and Immunology, University at Buffalo, Buffalo, NY 14214, USA.
authors.forename: Anyango D
authors.initials: AD
authors.lastname: Kamina
authors.affiliation: Department of Microbiology and Immunology and Witebsky Center for Microbial Pathogenesis and Immunology, University at Buffalo, Buffalo, NY 14214, USA. Electronic address: nw1@buffalo.edu.
authors.forename: Noreen
authors.initials: N
authors.lastname: Williams
mesh_terms: D000981:Antiprotozoal Agents / Q000494:pharmacology / Q000627:therapeutic use; D016503:Drug Delivery Systems; D055808:Drug Discovery; D055503:Protein Multimerization / Q000187:drug effects; D012270:Ribosomes / Q000737:chemistry* / Q000378:metabolism*; D014351:Trypanosomatina / Q000187:drug effects / Q000502:physiology*; D014352:Trypanosomiasis / Q000188:drug therapy
chemical_list: D000981:Antiprotozoal Agents
keywords: rRNA processing; ribosome assembly; ribosome structure.; trypanosomatids