title: Palladium-Catalyzed, Multicomponent Approach to β-Lactams via Aryl Halide Carbonylation.
abstract: A palladium-catalyzed multicomponent method for the synthesis of β-lactams from imines, aryl halides, and CO has been developed. This transformation proceeds via two tandem catalytic carbonylation reactions mediated by Pd(PtBu3)2and provides a route to prepare these products from five separate reagents. A diverse range of polysubstituted β-lactams can be generated by systematic variation of the substrates. This methodology can also be extended to the use of iodo-substituted imines to produce novel spirocyclic β-lactams in good yields and selectivity.
authors.affiliation: Department of Chemistry, McGill University , 801 Sherbrooke Street West, Montreal, Quebec H3A 0B8, Canada.
authors.forename: Gerardo M
authors.initials: GM
authors.lastname: Torres
authors.affiliation: Department of Chemistry, McGill University , 801 Sherbrooke Street West, Montreal, Quebec H3A 0B8, Canada.
authors.forename: Maximiliano
authors.initials: M
authors.lastname: De La Higuera Macias
authors.affiliation: Department of Chemistry, McGill University , 801 Sherbrooke Street West, Montreal, Quebec H3A 0B8, Canada.
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Quesnel
authors.affiliation: Department of Chemistry, McGill University , 801 Sherbrooke Street West, Montreal, Quebec H3A 0B8, Canada.
authors.forename: Oliver P
authors.initials: OP
authors.lastname: Williams
authors.affiliation: Department of Chemistry, McGill University , 801 Sherbrooke Street West, Montreal, Quebec H3A 0B8, Canada.|Department of Chemistry, Texas A&M University at Qatar , Doha, Qatar.
authors.forename: Veeranna
authors.initials: V
authors.lastname: Yempally
authors.affiliation: Department of Chemistry, Texas A&M University at Qatar , Doha, Qatar.
authors.forename: Ashfaq A
authors.initials: AA
authors.lastname: Bengali
authors.affiliation: Department of Chemistry, McGill University , 801 Sherbrooke Street West, Montreal, Quebec H3A 0B8, Canada.
authors.forename: Bruce A
authors.initials: BA
authors.lastname: Arndtsen