title: Association between rs7901695 and rs7903146 polymorphisms of the TCF7L2 gene and gestational diabetes in the population of Southern Poland.
abstract: The etiology of gestational diabetes mellitus (GDM) remains to be fully elucidated. Elevated risk for type 2 diabetes in patients with history of GDM and for GDM in women with familial history of diabetes may suggest that GDM and type 2 diabetes share a common genetic and environmental background. The TCF7L2 (Transcription Factor 7 Like 2) gene is one of the most important genetic factors of the established correlation with type 2 diabetes, and it may also play a role in the pathophysiology of GDM. The aim of the study was to assess the influence of two polymorphisms of the TCF7L2 gene (rs7901695 and rs7903146), which are associated with the development of type 2 diabetes, in women with GDM.
  
  
  
  The study included 50 women with glucose tolerance disorders diagnosed for the first time during the current pregnancy. Single nucleotide polymorphisms (SNPs) were genotyped using allelic discrimination. The results were confirmed using the sequencing method. Selected clinical parameters were also analyzed.
  
  
  
  No correlation between the studied polymorphisms of the TCF7L2 gene and GDM was observed. Glycemic control with diet or diet and insulin was associated with better control of the weight gain during pregnancy.
  
  
  
  No correlation between rs7903146 and rs7901695 polymorphisms of the TCF7L2 gene and GDM was found. Glycemic control with diet or diet and insulin is associated with better control of the weight gain during pregnancy.
authors.affiliation: Department of Cancer Genetics, Medical University of Lublin, Poland. michalak.malgorzata@gmail.com.
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Michalak-Wojnowska
authors.forename: Daria
authors.initials: D
authors.lastname: Gorczyca-Siudak
authors.forename: Tomasz
authors.initials: T
authors.lastname: Gorczyca
authors.forename: Barbara
authors.initials: B
authors.lastname: Mosiewicz
authors.forename: Anna
authors.initials: A
authors.lastname: Kwaśniewska
authors.forename: Agata
authors.initials: A
authors.lastname: Filip
authors.forename: Jerzy
authors.initials: J
authors.lastname: Mosiewicz
mesh_terms: D000328:Adult; D000483:Alleles; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D016022:Case-Control Studies; D016640:Diabetes, Gestational / Q000175:diagnosis* / Q000178:diet therapy / Q000188:drug therapy / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage; D007328:Insulin / Q000008:administration & dosage; D011044:Poland; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D012307:Risk Factors; D058118:Transcription Factor 7-Like 2 Protein / Q000235:genetics*; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D007004:Hypoglycemic Agents; D007328:Insulin; C544894:TCF7L2 protein, human; D058118:Transcription Factor 7-Like 2 Protein
keywords: TCF7L2 gene; genetic polymorphism; gestational diabetes mellitus