title: Organ Atrophy Induced by Sorafenib and Sunitinib - Quantitative Computed Tomography (CT) Evaluation of the Pancreas, Thyroid Gland and Spleen.
abstract: BACKGROUND
  To evaluate organ atrophy induced by sorafenib and sunitinib, we retrospectively reviewed the CT scans of renal cell carcinoma (RCC) patients receiving molecular targeted therapy (MTT) using sorafenib or sunitinib, and performed volumetric analysis of the pancreas, thyroid gland, and spleen.
  
  
  METHODS
  Thirteen RCC patients receiving MTT were assigned as the evaluation cases (MTT group), while thirteen additional RCC patients not receiving MTT were retrieved as the Control group. We evaluated the baseline and follow-up CT studies. The volume of the three organs estimated by CT volumetry was compared between the baseline and follow-up CTs. The atrophic ratio of the organ volume in the follow-up CT to that in the baseline CT was calculated, and compared between the MTT and Control groups.
  
  
  RESULTS
  All measured organs in the MTT group showed statistically significant volume loss, while no significant change was observed in the Control group. Mean atrophic ratio in the MTT group was 0.74, 0.58, and 0.82 for the pancreas, thyroid and spleen, respectively. The differences in atrophic ratios between both groups were all statistically significant (P<0.05).
  
  
  CONCLUSIONS
  Single-agent sorafenib or sunitinib therapy induced statistically significant atrophy in the pancreas, thyroid, and spleen.
authors.affiliation: Department of Diagnostic and Interventional Radiology, University of Tsukuba, Faculty of Medicine, Ibaraki, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Takahashi
authors.affiliation: Department of Diagnostic and Interventional Radiology, University of Tsukuba, Faculty of Medicine, Ibaraki, Japan.
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Nasu
authors.affiliation: Department of Diagnostic and Interventional Radiology, University of Tsukuba, Faculty of Medicine, Ibaraki, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Minami
authors.affiliation: Department of Urology, University of Tsukuba, Faculty of Medicine, Ibaraki, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Kojima
authors.affiliation: Department of Urology, University of Tsukuba, Faculty of Medicine, Ibaraki, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nishiyama
authors.affiliation: Department of Diagnostic and Interventional Radiology, University of Tsukuba, Faculty of Medicine, Ibaraki, Japan.
authors.forename: Toshitaka
authors.initials: T
authors.lastname: Ishiguro
authors.affiliation: Department of Diagnostic and Interventional Radiology, University of Tsukuba, Faculty of Medicine, Ibaraki, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Konishi
keywords: Atrophy; Pancreas; Spleen; Thyroid Gland