title: Correlation analysis of oral lesion sizes by various standardized criteria.
abstract: OBJECTIVE
  Requirements of an NCI contract examining a novel treatment for leukoplakia were to compare standard bi-dimensional measurement of oral lesions to examine for correlation with Response Evaluation Criteria in Solid Tumors (RECIST) criteria, and to examine the feasibility of digital image analysis for automated measurements.
  
  
  METHODS
  Retrospective review.
  
  
  METHODS
  We examined 13 patients by bi-dimensional measurement and compared these measurements to 1) RECIST criteria, 2) scalar digital measurements using a standardized measuring device within the photograph, and 3) pixel number.
  
  
  RESULTS
  RECIST criteria correlated (r-squared=0.8535, p<0.0001) with bi-dimensional measurements. Digitized measures in photographs correlated with bi-dimensional measurements (r-squared=0.6661, p=0.0007), but were time consuming. There was minimal to no correlation between pixel number in Adobe Photoshop and the other measures.
  
  
  CONCLUSIONS
  Bi-dimensional measurement of oral leukoplakia and RECIST criteria are highly correlated. Digital photography measurements, though highly correlative, are very cumbersome. We recommend bi-dimensional or longest length measurement and a simple photograph as standard of documentation for leukoplakia lesions.
authors.affiliation: University of Minnesota, Department of Otolaryngology.
authors.forename: Carrie E
authors.initials: CE
authors.lastname: Flanagan
authors.affiliation: University of Minnesota, Division of Oral Medicine and Diagnosis, School of Dentistry, Department of Diagnostic and Biological Sciences.
authors.forename: Nelson L
authors.initials: NL
authors.lastname: Rhodus
authors.affiliation: University of Minnesota, Department of Otolaryngology; Clinical Trials Office, University of Minnesota Cancer Center.
authors.forename: Kate A
authors.initials: KA
authors.lastname: Cole
authors.affiliation: Lung & Upper Aerodigestive Cancer Research Group, Division of Cancer Prevention, NCI, NIH, Bethesda, MD.
authors.forename: Eva
authors.initials: E
authors.lastname: Szabo
authors.affiliation: University of Minnesota, Department of Otolaryngology. Electronic address: ondre002@umn.edu.
authors.forename: Frank G
authors.initials: FG
authors.lastname: Ondrey
mesh_terms: D006801:Humans; D007972:Leukoplakia, Oral / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology*; D047495:PPAR gamma / Q000037:antagonists & inhibitors; D010781:Photography; D015203:Reproducibility of Results; D012189:Retrospective Studies; D047368:Tumor Burden
chemical_list: D047495:PPAR gamma