title: Site-Specific and Stoichiometric Stealth Polymer Conjugates of Therapeutic Peptides and Proteins.
abstract: As potent and selective therapeutic agents, peptides and proteins are an important class of drugs, but they typically have suboptimal pharmacokinetic profiles. One approach to solve this problem is their conjugation with "stealth" polymers. Conventional methods for conjugation of this class of polymers to peptides and proteins are typically carried out by reactions that have poor yield and provide limited control over the site of conjugation and the stoichiometry of the conjugate. To address these limitations, new chemical and biological approaches have been developed that provide new molecular tools in the bioconjugation toolbox to create stealth polymer conjugates of peptides and proteins with exquisite control over their properties. This review article highlights these recent advances in the synthesis of therapeutic peptide- and protein-stealth polymer conjugates.
authors.affiliation: Department of Biomedical Engineering, Duke University , 101 Science Drive, Durham, North Carolina 27708, United States.
authors.forename: Imran
authors.identifier: 0000-0003-4663-5215
authors.initials: I
authors.lastname: Ozer
authors.affiliation: Department of Biomedical Engineering, Duke University , 101 Science Drive, Durham, North Carolina 27708, United States.
authors.forename: Ashutosh
authors.initials: A
authors.lastname: Chilkoti
mesh_terms: D000818:Animals; D060326:Chemistry Techniques, Synthetic / Q000379:methods; D006801:Humans; D008958:Models, Molecular; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D011506:Proteins / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use
chemical_list: D010455:Peptides; D011108:Polymers; D011506:Proteins