title: A First Insight into the Genetic Diversity and Drug Susceptibility Pattern ofMycobacterium tuberculosisComplex in Zhejiang, China.
abstract: In this study, our aim was to determine the predominant genotypes among theMycobacterium tuberculosis(MTB) strains circulating in Zhejiang Province. In addition, we also sought to determine the potential associations between MTB genotypes and susceptibility to first-line drugs. Out of these isolates, 673 (71.6%) were classified into the Beijing genotype, while the other 267 (28.4%) were from non-Beijing families. The highest proportion of Beijing genotype was found in Huzhou (80.0%) and the lowest in Lishui (48.3%). Statistical analysis revealed that there was a significant difference in the prevalence of Beijing genotype among different regions (χ2= 17.57,P= 0.04). In addition, the overall proportions of drug resistance to INH, RIF, SM, and EMB were 13.2% (124/940), 21.8% (75/940), 3.4% (32/940), and 5.9% (55/940) in Zhejiang, respectively. Further comparison revealed that there was no significant difference in drug susceptibility profiles between Beijing and non-Beijing strains (P> 0.05). In conclusion, we describe the genetic diversity and drug susceptibility pattern of MTB in Zhejiang for the first time. Our data demonstrate that Beijing genotype is the predominant lineage in Zhejiang, while the distribution of Beijing-genotype strains shows geographic diversity. In addition, no correlation is observed between Beijing genotype and anti-TB drug resistance.
authors.affiliation: The Institute of TB Control, Zhejiang Provincial Center for Disease Control and Prevention, Zhejiang, China.
authors.forename: Zhengwei
authors.initials: Z
authors.lastname: Liu
authors.affiliation: National Center for TB Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Yu
authors.identifier: 0000-0002-4425-9124
authors.initials: Y
authors.lastname: Pang
authors.affiliation: The Institute of TB Control, Zhejiang Provincial Center for Disease Control and Prevention, Zhejiang, China.
authors.forename: Songhua
authors.initials: S
authors.lastname: Chen
authors.affiliation: The Institute of TB Control, Zhejiang Provincial Center for Disease Control and Prevention, Zhejiang, China.
authors.forename: Beibei
authors.initials: B
authors.lastname: Wu
authors.affiliation: The Institute of TB Control, Zhejiang Provincial Center for Disease Control and Prevention, Zhejiang, China.
authors.forename: Haibo
authors.initials: H
authors.lastname: He
authors.affiliation: The Institute of TB Control, Zhejiang Provincial Center for Disease Control and Prevention, Zhejiang, China.
authors.forename: Aizhen
authors.initials: A
authors.lastname: Pan
authors.affiliation: The Institute of TB Control, Zhejiang Provincial Center for Disease Control and Prevention, Zhejiang, China.
authors.forename: Xiaomeng
authors.identifier: 0000-0002-2409-2419
authors.initials: X
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D005260:Female; D014644:Genetic Variation; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000235:genetics*; D014376:Tuberculosis / Q000453:epidemiology / Q000235:genetics*