title: Non-Invasive Estimation Of Left Atrial Dominant Frequency In Atrial Fibrillation From Different Electrode Sites: Insight From Body Surface Potential Mapping.
abstract: The dominant driving sources of atrial fibrillation are often found in the left atrium, but the expression of left atrial activation on the body surface is poorly understood. Using body surface potential mapping and simultaneous invasive measurements of left atrial activation our aim was to describe the expression of the left atrial dominant fibrillation frequency across the body surface. 20 patients in atrial fibrillation were studied. The spatial distributions of the dominant atrial fibrillation frequency across anterior and posterior sites on the body surface were quantified. Their relationship with invasive left atrial dominant fibrillation frequency was assessed by linear regression analysis, and the coefficient of determination was calculated for each body surface site. The correlation between intracardiac and body surface dominant frequency was significantly higher with posterior compared with anterior sites (coefficient of determination 67±8% vs 48±2%, p<0.001). The site with largest coefficient of determination was 79.6% (p<0.001) and was a posterior site. In comparison with the site closest to lead V1 it had a coefficient of determination of 23.0% (p=0.033), and with the posterior body surface site closest to lead V9 had a coefficient of determination of 70.3% (p<0.001). Left atrial dominant fibrillation frequency was more closely represented at posterior body surface sites.
authors.affiliation: Marjan Bojarnejad, Institute of Cellular Medicine, Newcastle University, Medical School, Newcastle upon Tyne, NE2 4HH. James R Blake, Regional Medical Physics Department, Royal Victoria Infirmary, Newcastle upon Tyne, NE4 1LP. John Bourke, Cardiology Department, Freeman Hospital, Newcastle upon Tyne, NE7 7DN. Ewan Shepherd, Cardiology Department, Freeman Hospital, Newcastle upon Tyne, NE7 7DN. Alan Murray, Institute of Cellular Medicine, Newcastle University, Medical School, Newcastle upon Tyne, NE2 4HH. Philip Langley, School of Engineering, University of Hull, Hull, HU6 7RX.
authors.forename: Marjan
authors.initials: M
authors.lastname: Bojarnejad
authors.affiliation: Marjan Bojarnejad, Institute of Cellular Medicine, Newcastle University, Medical School, Newcastle upon Tyne, NE2 4HH. James R Blake, Regional Medical Physics Department, Royal Victoria Infirmary, Newcastle upon Tyne, NE4 1LP. John Bourke, Cardiology Department, Freeman Hospital, Newcastle upon Tyne, NE7 7DN. Ewan Shepherd, Cardiology Department, Freeman Hospital, Newcastle upon Tyne, NE7 7DN. Alan Murray, Institute of Cellular Medicine, Newcastle University, Medical School, Newcastle upon Tyne, NE2 4HH. Philip Langley, School of Engineering, University of Hull, Hull, HU6 7RX.
authors.forename: James R
authors.initials: JR
authors.lastname: Blake
authors.affiliation: Marjan Bojarnejad, Institute of Cellular Medicine, Newcastle University, Medical School, Newcastle upon Tyne, NE2 4HH. James R Blake, Regional Medical Physics Department, Royal Victoria Infirmary, Newcastle upon Tyne, NE4 1LP. John Bourke, Cardiology Department, Freeman Hospital, Newcastle upon Tyne, NE7 7DN. Ewan Shepherd, Cardiology Department, Freeman Hospital, Newcastle upon Tyne, NE7 7DN. Alan Murray, Institute of Cellular Medicine, Newcastle University, Medical School, Newcastle upon Tyne, NE2 4HH. Philip Langley, School of Engineering, University of Hull, Hull, HU6 7RX.
authors.forename: John
authors.initials: J
authors.lastname: Bourke
authors.affiliation: Marjan Bojarnejad, Institute of Cellular Medicine, Newcastle University, Medical School, Newcastle upon Tyne, NE2 4HH. James R Blake, Regional Medical Physics Department, Royal Victoria Infirmary, Newcastle upon Tyne, NE4 1LP. John Bourke, Cardiology Department, Freeman Hospital, Newcastle upon Tyne, NE7 7DN. Ewan Shepherd, Cardiology Department, Freeman Hospital, Newcastle upon Tyne, NE7 7DN. Alan Murray, Institute of Cellular Medicine, Newcastle University, Medical School, Newcastle upon Tyne, NE2 4HH. Philip Langley, School of Engineering, University of Hull, Hull, HU6 7RX.
authors.forename: Ewan
authors.initials: E
authors.lastname: Shepherd
authors.affiliation: Marjan Bojarnejad, Institute of Cellular Medicine, Newcastle University, Medical School, Newcastle upon Tyne, NE2 4HH. James R Blake, Regional Medical Physics Department, Royal Victoria Infirmary, Newcastle upon Tyne, NE4 1LP. John Bourke, Cardiology Department, Freeman Hospital, Newcastle upon Tyne, NE7 7DN. Ewan Shepherd, Cardiology Department, Freeman Hospital, Newcastle upon Tyne, NE7 7DN. Alan Murray, Institute of Cellular Medicine, Newcastle University, Medical School, Newcastle upon Tyne, NE2 4HH. Philip Langley, School of Engineering, University of Hull, Hull, HU6 7RX.
authors.forename: Alan
authors.initials: A
authors.lastname: Murray
authors.affiliation: Marjan Bojarnejad, Institute of Cellular Medicine, Newcastle University, Medical School, Newcastle upon Tyne, NE2 4HH. James R Blake, Regional Medical Physics Department, Royal Victoria Infirmary, Newcastle upon Tyne, NE4 1LP. John Bourke, Cardiology Department, Freeman Hospital, Newcastle upon Tyne, NE7 7DN. Ewan Shepherd, Cardiology Department, Freeman Hospital, Newcastle upon Tyne, NE7 7DN. Alan Murray, Institute of Cellular Medicine, Newcastle University, Medical School, Newcastle upon Tyne, NE2 4HH. Philip Langley, School of Engineering, University of Hull, Hull, HU6 7RX.
authors.forename: Philip
authors.initials: P
authors.lastname: Langley
keywords: Atrial Arrhythmia; Atrial Fibrillation; Body Surface Potential Mapping; Intra-Atrial Electrograms; Signal Processing