title: One-pot synthesis of injectable methylcellulose hydrogel containing calcium phosphate nanoparticles.
abstract: A thermo-sensitive hydrogel based on calcium phosphate nanoparticles was prepared using a novel one-pot method in which added precursor salts induced a salt-out effect in the methylcellulose (MC) solution. The calcium phosphate nanoparticles were synthesized in situ from precursor ions (Ca2+and HPO42-) in the hydrogel, and residual ions (HPO42-and Cl-) in the formation of the nanoparticles decreased the gelation temperature of the MC solution. This one-pot synthesis was an effective way to streamline the previous multi-step process and to easily prepare a thermo-sensitive hydrogel containing bioactive nanoparticles. The thermo-sensitive properties of different concentrations of MC hydrogels were characterized by a rheometer and infrared (IR) spectroscopy. The gelation behavior of MC according to the addition of various salts was monitored by rheometer. With respect to a selected concentration and precursor, the structure of the MC hydrogel containing calcium phosphate nanoparticles was analyzed by scanning electron microscopy (SEM), X-ray diffraction (XRD) and IR.
authors.affiliation: Department of Advanced Organic Materials and Textile Engineering System, Chungnam National University, Daejeon, South Korea.
authors.forename: Hanna
authors.initials: H
authors.lastname: Park
authors.affiliation: Department of Advanced Organic Materials and Textile Engineering System, Chungnam National University, Daejeon, South Korea.
authors.forename: Min Hee
authors.initials: MH
authors.lastname: Kim
authors.affiliation: Department of Advanced Organic Materials and Textile Engineering System, Chungnam National University, Daejeon, South Korea. Electronic address: yyipmk@cnu.ac.kr.
authors.forename: Young Il
authors.initials: YI
authors.lastname: Yoon
authors.affiliation: Department of Advanced Organic Materials and Textile Engineering System, Chungnam National University, Daejeon, South Korea. Electronic address: parkwh@cnu.ac.kr.
authors.forename: Won Ho
authors.initials: WH
authors.lastname: Park
mesh_terms: D002130:Calcium Phosphates / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*; D008747:Methylcellulose / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles / Q000737:chemistry*; D013696:Temperature; D014961:X-Ray Diffraction
chemical_list: D002130:Calcium Phosphates; D020100:Hydrogels; D008747:Methylcellulose
keywords: Calcium phosphate nanoparticles; In situ formation; Injectable gel; Methylcellulose; Thermo-sensitive hydrogel