title: Transmembrane Fluoride Transport: Direct Measurement and Selectivity Studies.
abstract: Fluoride has been overlooked as a target in the development of synthetic anion transporters despite natural fluoride transport channels being recently discovered. In this paper we report the direct measurement of fluoride transport across lipid bilayers facilitated by a series of strapped calix[4]pyrroles and show that these compounds facilitate transport via an electrogenic mechanism (determined using valinomycin and monensin coupled transport assays and an additional osmotic response assay). An HPTS transport assay was used to quantify this electrogenic process and assess the interference of naturally occurring fatty acids with the transport process and Cl-over H+/OH-transport selectivity.
authors.affiliation: Chemistry, University of Southampton , Southampton SO17 1BJ, U.K.
authors.forename: Harriet J
authors.initials: HJ
authors.lastname: Clarke
authors.affiliation: Chemistry, University of Southampton , Southampton SO17 1BJ, U.K.
authors.forename: Ethan N W
authors.initials: EN
authors.lastname: Howe
authors.affiliation: Chemistry, University of Southampton , Southampton SO17 1BJ, U.K.
authors.forename: Xin
authors.initials: X
authors.lastname: Wu
authors.affiliation: Department of Chemistry-Organic Chemistry, Kaiserslautern University of Technology , Erwin-Schrödinger-Straße, 67663 Kaiserslautern, Germany.
authors.forename: Fabian
authors.initials: F
authors.lastname: Sommer
authors.affiliation: Chemistry, University of Southampton , Southampton SO17 1BJ, U.K.
authors.forename: Masafumi
authors.initials: M
authors.lastname: Yano
authors.affiliation: Chemistry, University of Southampton , Southampton SO17 1BJ, U.K.
authors.forename: Mark E
authors.initials: ME
authors.lastname: Light
authors.affiliation: Department of Chemistry-Organic Chemistry, Kaiserslautern University of Technology , Erwin-Schrödinger-Straße, 67663 Kaiserslautern, Germany.
authors.forename: Stefan
authors.identifier: 0000-0003-0526-7014
authors.initials: S
authors.lastname: Kubik
authors.affiliation: Chemistry, University of Southampton , Southampton SO17 1BJ, U.K.
authors.forename: Philip A
authors.identifier: 0000-0001-9751-4910
authors.initials: PA
authors.lastname: Gale