title: An elevated 1-h post- load glucose level during the oral glucose tolerance test detects prediabetes.
abstract: OBJECTIVE
  The objective of the study was to compare the diagnosis of dysglycemic states by conventional oral glucose tolerance test (OGTT) criteria (fasting and 2-h plasma glucose) with the 1-h post-load plasma glucose level.
  
  
  METHODS
  34 individuals (mean age: 55±13years; BMI: 27.7±6.3kg/m2) at risk for prediabetes were administered a 75g OGTT. Individuals with normal glucose tolerance (NGT) or prediabetes were identified according to fasting and/or 2-h plasma glucose (PG) concentrations. Subsequently, subjects were divided in 2 groups: group 1 (n=21) with a 1-h PG<155mg/dl and group 2 (n=13) with a 1-h PG≥155mg/dl. HOMA was performed to assess β-cell function and insulin sensitivity.
  
  
  RESULTS
  NGT or prediabetes based on conventional criteria correlated with the 1-h PG<or≥155mg/dl (p<0.001). Moreover, the 1-h PG≥155mg/dl was associated with higher HbA1clevels (6.1±0.5 vs. 5.5±0.3%, p<0.001) and significantly impaired insulin secretion and hyperbolic product (BxS) on HOMA test vs. 1-h PG<155mg/dl.
  
  
  CONCLUSIONS
  The 1-h post-load plasma glucose value ≥155mg/dl is strongly associated with conventional criteria for (pre)diabetes and alterations of β-cell function.
authors.affiliation: Cliniques Universitaires Saint-Luc, Service d'Endocrinologie et Nutrition, B-1200 Bruxelles, Belgium. Electronic address: martin.buysschaert@uclouvain.be.
authors.forename: Martin
authors.initials: M
authors.lastname: Buysschaert
authors.affiliation: NYU School of Medicine, Department of Medicine, Division of Endocrinology and Metabolism, NYU Langone Diabetes Prevention Program, 530 First Avenue, Schwartz East, New-York, NY10.016, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Bergman
authors.affiliation: Hôpital National Blaise Compaoré, Ouagadougou, Burkina Faso.
authors.forename: Donald
authors.initials: D
authors.lastname: Yanogo
authors.affiliation: NYU School of Medicine, Department of Population Health Center for Healthful Behavior Change, New York, NY 10016, USA.
authors.forename: Ram
authors.initials: R
authors.lastname: Jagannathan
authors.affiliation: Cliniques Universitaires Saint-Luc, Service d'Endocrinologie et Nutrition, B-1200 Bruxelles, Belgium.
authors.forename: Benoit
authors.initials: B
authors.lastname: Buysschaert
authors.affiliation: Cliniques Universitaires Saint-Luc, Service d'Endocrinologie et Nutrition, B-1200 Bruxelles, Belgium.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Preumont
mesh_terms: D000328:Adult; D000368:Aged; D015331:Cohort Studies; D005260:Female; D005951:Glucose Tolerance Test / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period; D011236:Prediabetic State / Q000097:blood / Q000175:diagnosis*
keywords: 1-h post-load glycemia; Diagnosis; HOMA; HbA(1c); OGTT; Prediabetes