title: Autophagy, a key mechanism of oncogenesis and resistance in leukemia.
abstract: Autophagy is a lysosomal pathway involved in degradation of intracellular material. It appears as an adaptation mechanism that is essential for cellular homeostasis in response to various stress conditions. Over the past decade, many studies have linked alteration of autophagy with cancer initiation and progression, autoimmune, inflammatory, metabolic, and degenerative diseases. This review highlights recent findings on the impact of autophagy on leukemic transformation of normal hematopoietic stem cells and summarizes its role on leukemic cell response to chemotherapy.
authors.affiliation: INSERM U1065, Centre Méditerranéen de Médecine Moléculaire, Université Côte d'Azur, Nice, France; and.
authors.forename: Patrick
authors.identifier: 0000-0002-2481-8275
authors.initials: P
authors.lastname: Auberger
authors.affiliation: INSERM Unité Mixte de Recherche 944, Institut Universitaire d'Hématologie, Hôpital St Louis, Paris, France.
authors.forename: Alexandre
authors.identifier: 0000-0002-3997-9282
authors.initials: A
authors.lastname: Puissant
mesh_terms: D000818:Animals; D000969:Antinematodal Agents / Q000494:pharmacology / Q000627:therapeutic use; D001343:Autophagy / Q000187:drug effects; D063646:Carcinogenesis / Q000187:drug effects / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000187:drug effects / Q000473:pathology*; D019008:Drug Resistance, Neoplasm; D006412:Hematopoietic Stem Cells / Q000187:drug effects / Q000473:pathology*; D006801:Humans; D007938:Leukemia / Q000188:drug therapy / Q000473:pathology*
chemical_list: D000969:Antinematodal Agents