title: Micro-/nanofibers prepared via co-assembly of paclitaxel and dextran.
abstract: In this paper, we reported the preparation of micro-/nanofibers via co-assembly with paclitaxel (PTX) and dextran (DEX). The co-assembly fibers formed in PTX and DEX mixture solution via non-covalent interactions including hydrophilic/hydrophobic interactions and π-π stacking. The micro-/nanofibers could be obviously observed when the mixed solution became turbid and ivory-white in color. The properties of fibers were characterized by SEM, TEM, FTIR, DSC, XRD, in vitro release and MTT assay. The length of fibers could reach several centimeters. The diameter of microfibers and nanofibers was about 800nm and 80nm, respectively. In addition, the PTX loading efficiency was over 78% in co-assembly fibers and up to 84% when PTX and DEX (Mw: 40,000) both were 2mg/mL. The sustained drug release and low cytotoxicity in vitro of PTX/DEX fibers were also demonstrated. Therefore, we believe that PTX/DEX micro-/nanofibers would have great potential for drug delivery of PTX.
authors.affiliation: Instrumental Analysis Center, Shanghai Jiao Tong University, 200240 Shanghai, China; State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University, 201620 Shanghai, China; State Key Laboratory of Metal Matrix Composites, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 200240 Shanghai, China.
authors.forename: Tongtong
authors.initials: T
authors.lastname: Zhou
authors.affiliation: Instrumental Analysis Center, Shanghai Jiao Tong University, 200240 Shanghai, China; State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University, 201620 Shanghai, China. Electronic address: bshzhu@sjtu.edu.cn.
authors.forename: Bangshang
authors.initials: B
authors.lastname: Zhu
authors.affiliation: State Key Laboratory of Metal Matrix Composites, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 200240 Shanghai, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
authors.affiliation: Instrumental Analysis Center, Shanghai Jiao Tong University, 200240 Shanghai, China; State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University, 201620 Shanghai, China; State Key Laboratory of Metal Matrix Composites, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 200240 Shanghai, China.
authors.forename: Yongjia
authors.initials: Y
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Metal Matrix Composites, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 200240 Shanghai, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Ren
authors.affiliation: Instrumental Analysis Center, Shanghai Jiao Tong University, 200240 Shanghai, China; State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University, 201620 Shanghai, China; State Key Laboratory of Metal Matrix Composites, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 200240 Shanghai, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Tang
authors.affiliation: Instrumental Analysis Center, Shanghai Jiao Tong University, 200240 Shanghai, China; State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University, 201620 Shanghai, China; State Key Laboratory of Metal Matrix Composites, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 200240 Shanghai, China.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Ma
authors.affiliation: State Key Laboratory of Metal Matrix Composites, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 200240 Shanghai, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Su
authors.affiliation: State Key Laboratory of Metal Matrix Composites, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 200240 Shanghai, China.
authors.forename: Xinyuan
authors.initials: X
authors.lastname: Zhu
mesh_terms: D000818:Animals; D002460:Cell Line; D003911:Dextrans; D004337:Drug Carriers; D016503:Drug Delivery Systems; D006367:HeLa Cells; D006801:Humans; D051379:Mice; D008823:Micelles; D057139:Nanofibers; D017239:Paclitaxel / Q000008:administration & dosage*
chemical_list: D003911:Dextrans; D004337:Drug Carriers; D008823:Micelles; D017239:Paclitaxel
keywords: Co-assembly; Dextran; Micro-/nanofibers; Non-covalent interactions; Paclitaxel