title: Oral lichen planus: therapy and phenotype.
abstract: BACKGROUND
  Lichen planus (LP) is a mucocutaneous disease of chronic inflammatory nature. Although many therapeutic options are available, none are curative. The aim of this article was to describe a therapeutic algorithm that take into consideration the clinical futures of oral LP (OLP).
  
  
  METHODS
  Patients affected by symptomatic OLP were enrolled into three groups to receive cyclosporine mouthwash, retinoic acid lotion 0.05%, and autologous platelet-rich plasma (PRP) gel in the treatment of reticular, plaque-like, and erosive-type respectively. The products were applied as follows: retinoic acid BID for 8 weeks, cyclosporine mouthwash OD for 8 weeks, PRP once a week for 8 weeks. Patients were assessed at 2, 4, 8, and 12 weeks. Improvement was evaluated as complete response, partial response and no response.
  
  
  RESULTS
  A total of 20 Caucasian patients, 8 male and 12 female, mean age 56 years (range 40-74) concluded the study. Seven patients showed a complete response, 7 patients a partial response, and 6 patients no response.
  
  
  CONCLUSIONS
  We propose a therapeutic algorithm that take into consideration the clinical features and symptoms of OLP. Long-term experience on larger series of cases are necessary to confirm our data.
authors.affiliation: Department of Otolorology and Maxillofacial Surgery, F. Tappeiner Hospital, Merano, Bolzano, Italy.
authors.forename: Bruno
authors.initials: B
authors.lastname: Loré
authors.affiliation: Unit of Dermatology, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy - rositasaraceno@yahoo.it.
authors.forename: Rosita
authors.initials: R
authors.lastname: Saraceno
authors.affiliation: Department of Otolorology and Maxillofacial Surgery, F. Tappeiner Hospital, Merano, Bolzano, Italy.
authors.forename: Giulio
authors.initials: G
authors.lastname: Poladas
authors.affiliation: Department of Dermatology, Medical University of Tirana, Tirana, Albania.
authors.forename: Monika
authors.initials: M
authors.lastname: Fida
authors.affiliation: Department of Otolorology and Maxillofacial Surgery, F. Tappeiner Hospital, Merano, Bolzano, Italy.
authors.forename: Charbel
authors.initials: C
authors.lastname: Khoury
authors.affiliation: Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, Rome, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Arcuri
authors.affiliation: Department of Otolorology and Maxillofacial Surgery, F. Tappeiner Hospital, Merano, Bolzano, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Magnato
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000465:Algorithms; D016572:Cyclosporine / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D017676:Lichen Planus, Oral / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D010865:Pilot Projects; D053657:Platelet-Rich Plasma; D013997:Time Factors; D016896:Treatment Outcome; D014212:Tretinoin / Q000008:administration & dosage*
chemical_list: D007166:Immunosuppressive Agents; D014212:Tretinoin; D016572:Cyclosporine