title: CT-guided percutaneous laser ablation of metastatic lung cancer: three cases report and literature review.
abstract: OBJECTIVE
  To report the efficacy and safety of CT-guided percutaneous laser ablation (PLA) for metastatic lung tumors.
  
  
  METHODS
  Three cases of metastatic lung cancer underwent CT-guided PLA, and we searched for previously published articles on the minimally invasive CT-guided RFA or MWA for lung tumors in recent five years.
  
  
  RESULTS
  With the guidance of CT, all lesions had good prognosis under laser ablation. Case 1 suffering from severe pulmonary dysfunction and diffuse pulmonary bullae, had small pneumothorax. CT scan obtained four months following the ablation showed two lesions had complete responses and one partial response. Case 2 had successful complete response with absent lung mass, and also had a good postoperative condition without any discomfort in the two-month follow-up. Case 3 showed partial response and improved greatly after five months. 962 cases (mean age of 45.7 years, 62.2% male) of 1297 lung tumors with detailed information were identified from 27 articles. Of these cases, the minority manifested complications such as pneumothorax, hemoptysis, hemothorax, pneumonia, pain and fever.
  
  
  CONCLUSIONS
  Percutaneous CT-guided PLA could be a safe and promising minimally invasive treatment for patients with primary lung cancer or unresectable pulmonary metastases, especially multineedle PLA in large tumors, which still needs more large-scale prospective studies to convince this method in the future.
authors.affiliation: Department of Ultrasonography, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Qiyu
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Guo
authors.initials: G
authors.lastname: Tian
authors.affiliation: Department of Hepatobiliary Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Fen
authors.initials: F
authors.lastname: Chen
authors.affiliation: Department of Ultrasonography, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Liyun
authors.initials: L
authors.lastname: Zhong
authors.affiliation: Department of Ultrasonography, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Tian'an
authors.initials: T
authors.lastname: Jiang
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000601:surgery*; D017115:Catheter Ablation / Q000379:methods; D005260:Female; D006801:Humans; D053685:Laser Therapy / Q000379:methods*; D008175:Lung Neoplasms / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D025321:Surgery, Computer-Assisted / Q000379:methods*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
keywords: CT-guided; computed tomography; laser ablation; lung; lung cancer