title: Acute and chronic Graft-versus-host disease after hematopoietic stem cell transplantation.
abstract: graft-versus-host disease (GVHD) is one of the main complications of hematopoietic stem cell transplantation, affecting about 50% to 80% of the patients. Acute GVHD and its clinical manifestations are discussed in this article, as well as the new NIH criteria for the diagnosis and classification of chronic GVHD. Therapy for both chronic and acute GVHD is an important field of discussion, as there is no proven superiority for the majority of therapies used after primary treatment has failed. Hence, this review is meant to be a useful consultation tool for hematologists dealing with this complex transplantation procedure complication.
authors.affiliation: Hematology and Technical Supervisor of Adult BMTS, Universidade Federal do Paraná, Brazil.
authors.forename: Vaneuza A M
authors.initials: VA
authors.lastname: Funke
authors.affiliation: Centro de Transplante de Medula Óssea, Instituto Nacional do Cancer, Brazil.
authors.forename: Maria Claudia Rodrigues
authors.initials: MC
authors.lastname: Moreira
authors.affiliation: Transplant Unit, UNICAMP, Brazil.
authors.forename: Afonso Celso
authors.initials: AC
authors.lastname: Vigorito
mesh_terms: D000208:Acute Disease; D002908:Chronic Disease; D005260:Female; D006086:Graft vs Host Disease / Q000145:classification / Q000209:etiology* / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008297:Male; D012307:Risk Factors; D012720:Severity of Illness Index