title: The Effect of Immunonutrition on the Postoperative Complications in Thymoma with Myasthenia Gravis.
abstract: Object. To test whether preoperative immunonutrition is efficacious in reducing postoperative complications in patients of thymoma with myasthenia gravis (MG).Material and Methods. A total of 244 patients operated on for thymoma with myasthenia gravis were prospectively assigned to two groups, each receiving seven-day preoperative and seven-day postoperative nutrition. The patients in immunonutrition group were given oral immunonutrition (IN). The patients in control group received oral standard nutrition. Immunonutritional and inflammatory biomarkers (IgA, IgG, IgM, CD3t, CD4t, CD8t, CD4t/CD8t ratio, NK-cell, prealbumin, albumin, white blood cells counts, and C-reactive protein) and clinical variables (age, gender, BMI, performance status, type of thymoma, type of MG, operative time, pathology, operative approach, postoperative complications, quantity of drainage, hospital stays) were examined.Results. A significant reduction in the length of hospital stay, quantity of drainage, and postoperative complications was observed in the IN group (p< 0.05). An increase in the level of IgA, IgG, IgM, CD3+T, CD4+T, CD4+T/CD8+T, WBC, CRP, and NK-cell in the IN group was observed after thymectomy, while a decrease was seen with regard to prealbumin and albumin (p< 0.05).Conclusion. Preoperative immunonutrition support is effective in reducing postoperative complications in patients of thymoma with MG. It helps to lower the risk of postoperative infectious complications and hospital stays.
authors.affiliation: Department of Thoracic Surgery, The First Hospital of Jilin University, 71 Xinmin Street, Changchun 130021, China.
authors.forename: Yanzhong
authors.initials: Y
authors.lastname: Xin
authors.affiliation: Department of Thoracic Surgery, The First Hospital of Jilin University, 71 Xinmin Street, Changchun 130021, China.
authors.forename: Hongfei
authors.initials: H
authors.lastname: Cai
authors.affiliation: Institute for the Control of Agrochemicals, Ministry of Agriculture, Beijing 100125, China.
authors.forename: Lihui
authors.initials: L
authors.lastname: Wu
authors.affiliation: Department of Thoracic Surgery, The First Hospital of Jilin University, 71 Xinmin Street, Changchun 130021, China.
authors.forename: Youbin
authors.identifier: 0000-0002-7434-3888
authors.initials: Y
authors.lastname: Cui
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism; D017252:CD3 Complex / Q000378:metabolism; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000378:metabolism; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000378:metabolism; D007074:Immunoglobulin G / Q000378:metabolism; D007075:Immunoglobulin M / Q000378:metabolism; D007694:Killer Cells, Natural / Q000378:metabolism; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000178:diet therapy* / Q000601:surgery*; D011183:Postoperative Complications; D011184:Postoperative Period; D011300:Preoperative Care; D011446:Prospective Studies; D013934:Thymectomy; D013945:Thymoma / Q000178:diet therapy* / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D017252:CD3 Complex; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D002097:C-Reactive Protein