title: The efficacy and safety of 2-μm continuous laser in the treatment of high-risk patients with benign prostatic hyperplasia.
abstract: Two-micrometer laser resection of prostate-tangerine technique dissects whole prostatic lobes off the surgical capsular, similar to peeling a tangerine. The present study aimed to evaluate the safety and efficacy of 2-μm continuous laser vaporization in the treatment of high-risk patients with benign prostatic hyperplasia (BPH) during the 24-month follow-up. The study included 248 patients with moderate to severe lower urinary tract symptoms who underwent 2-μm continuous laser vaporization of the prostate. All patients were accompanied with different degree comorbidities and 94 patients were taking oral anticoagulants. BPH was successfully treated with 2-μm continuous laser vaporization in all patients. Mean pre-operative prostate volume was 76 ± 25.3 ml and mean operative time was 49.8 ± 16.5 min. There were no major complications intra-operatively or postoperatively, and no blood transfusions were needed. About 20 patients (8.1%) needed bladder irrigation postoperatively. Average catheterization time was 2.0 ± 1.8 days (range 1-5 days). Four patients required reoperation due to enlarged prostates from residual adenoma. At 3-, 6-, 12-, and 24-month follow-ups, maximum urinary flow rates (Qmax) increased from 6.9 ± 1.7 to 19.1 ± 4.2, 19.5 ± 4.6, 19.4 ± 4.6, and 19.5 ± 4.1 ml/s, respectively. Mean International Prostate Symptom Scores (IPSS) decreased from 27.6 ± 5.1 (pre-operation) to 9.2 ± 2.6, 7.12 ± 1.42, 6.18 ± 1.32, and 6.25 ± 1.30 at 3-, 6-, 12-, and 24-month post-operation, respectively. Two-micrometer continuous laser vaporization is a safe and effective surgical endoscopic technique associated with low complication rate in BPH patients at high risk and those on anticoagulation therapy who have severe LUTS caused by BPH.
authors.affiliation: Department of Urology, The Second Affiliated Hospital of Soochow University, Suzhou, China. tw27024@163.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Tao
authors.affiliation: Department of Urology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Chuanyang
authors.initials: C
authors.lastname: Sun
authors.affiliation: Department of Urology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Boxin
authors.initials: B
authors.lastname: Xue
authors.affiliation: Department of Urology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Dongrong
authors.initials: D
authors.lastname: Yang
authors.affiliation: Department of Urology, The Sir Run Run Shaw Hospital, College of Medical Sciences, Zhejiang University, Hangzhou, China.
authors.forename: Mingchao
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Urology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Chunjie
authors.initials: C
authors.lastname: Cai
authors.affiliation: Department of Urology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Yuxi
authors.initials: Y
authors.lastname: Shan
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D007834:Lasers / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology; D011184:Postoperative Period; D011300:Preoperative Care; D011470:Prostatic Hyperplasia / Q000601:surgery*; D012307:Risk Factors; D016896:Treatment Outcome
keywords: 2-μm wave continuous laser; Anticoagulants; Benign prostatic hyperplasia; Laser surgery