title: Liposome-based drug co-delivery systems in cancer cells.
abstract: Combination therapy and nanotechnology offer a promising therapeutic method in cancer treatment. By improving drug's pharmacokinetics, nanoparticulate systems increase the drug's therapeutic effects while decreasing its adverse side effects related to high dosage. Liposomes are extensively used as drug delivery systems and several liposomal nanomedicines have been approved for clinical applications. In this regard, liposome-based combination chemotherapy (LCC) opens a novel avenue in drug delivery research and has increasingly become a significant approach in clinical cancer treatment. This review paper focuses on LCC strategies including co-delivery of: two chemotherapeutic drugs, chemotherapeutic agent with anti-cancer metals, and chemotherapeutic agent with gene agents and ligand-targeted liposome for co-delivery of chemotherapeutic agents. Definitely, the multidisciplinary method may help improve the efficacy of cancer therapy. An extensive literature review was performed mainly using PubMed.
authors.affiliation: Chronic Kidney Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Sepideh
authors.initials: S
authors.lastname: Zununi Vahed
authors.affiliation: Chronic Kidney Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Drug Applied Research Center, Tabriz University of Medical Science, Tabriz, Iran.
authors.forename: Roya
authors.initials: R
authors.lastname: Salehi
authors.affiliation: Chronic Kidney Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Drug Applied Research Center, Tabriz University of Medical Science, Tabriz, Iran.
authors.forename: Soodabeh
authors.initials: S
authors.lastname: Davaran
authors.affiliation: Drug Applied Research Center, Tabriz University of Medical Science, Tabriz, Iran; Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: sharifi.ghazi@gmail.com.
authors.forename: Simin
authors.initials: S
authors.lastname: Sharifi
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D006801:Humans; D008081:Liposomes; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D008081:Liposomes
keywords: Cancer treatment; Chemotherapy; Co-delivery; Combination therapy; Liposome