title: Clinical, angiographic, IVUS, and OCT predictors for irregular protrusion after coronary stenting.
abstract: OBJECTIVE
  Irregular protrusion identified by optical coherence tomography (OCT) immediately following stent implantation has been reported as an independent predictor for adverse cardiac events at one year. However, baseline characteristics for the development of irregular protrusion are unknown. The aim of the study was to identify predictors for irregular protrusion following stent implantation.
  
  
  RESULTS
  A total of 900 lesions in 786 patients who had post-stent OCT imaging were analysed. The patients were divided into two groups: those with (484 lesions, 456 patients) and those without (416 lesions, 330 patients) irregular protrusion. Baseline characteristics (n=786) as well as pre-stent angiogram (n=786), intravascular ultrasound (IVUS; n=31) and OCT (n=159) findings were compared between the two groups. Multivariate analysis showed that patients with irregular protrusion had higher low-density lipoprotein (LDL) cholesterol levels and lesions with greater stent length, greater percent atheroma volume on IVUS, greater lipid content and a higher prevalence of thrombus on OCT before stent implantation.
  
  
  CONCLUSIONS
  Irregular protrusion was found more frequently in patients with higher LDL cholesterol levels. In addition, lesions treated with longer stents, with greater plaque burden, larger lipid content and a higher prevalence of thrombus were identified as predictors for irregular protrusion following stent implantation.
authors.affiliation: Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
authors.forename: Krzysztof L
authors.initials: KL
authors.lastname: Bryniarski
authors.forename: Seung-Jea
authors.initials: SJ
authors.lastname: Tahk
authors.forename: So-Yeon
authors.initials: SY
authors.lastname: Choi
authors.forename: Tsunenari
authors.initials: T
authors.lastname: Soeda
authors.forename: Takumi
authors.initials: T
authors.lastname: Higuma
authors.forename: Erika
authors.initials: E
authors.lastname: Yamamoto
authors.forename: Lei
authors.initials: L
authors.lastname: Xing
authors.forename: Jiannan
authors.initials: J
authors.lastname: Dai
authors.forename: Thomas
authors.initials: T
authors.lastname: Zanchin
authors.forename: Hang
authors.initials: H
authors.lastname: Lee
authors.forename: Ik-Kyung
authors.initials: IK
authors.lastname: Jang
mesh_terms: D000368:Aged; D008078:Cholesterol, LDL / Q000097:blood; D017023:Coronary Angiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects*; D015607:Stents / Q000009:adverse effects*; D041623:Tomography, Optical Coherence / Q000379:methods*; D018084:Ultrasonography, Interventional / Q000379:methods*
chemical_list: D008078:Cholesterol, LDL