title: Anion Recognition as a Supramolecular Switch of Cell Internalization.
abstract: The cell internalization of designed oligoarginine peptides equipped with six glutamic acid residues and an anionic pyranine at the N-terminus is triggered upon addition of a supramolecular host. This host binds specifically to the pyranine moiety, enabling the complex to traverse the cell membrane. Interestingly, none of the components, neither the host nor the guest, are able to cross the cell membrane on their own.
authors.affiliation: Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS) and Departamento de Química Orgánica, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
authors.forename: Jéssica
authors.initials: J
authors.lastname: Rodríguez
authors.affiliation: Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS) and Departamento de Química Orgánica, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.|Department of Chemistry, The University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.
authors.forename: Jesús
authors.initials: J
authors.lastname: Mosquera
authors.affiliation: Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS) and Departamento de Química Orgánica, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
authors.forename: José R
authors.initials: JR
authors.lastname: Couceiro
authors.affiliation: Department of Chemistry, The University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.
authors.forename: Jonathan R
authors.initials: JR
authors.lastname: Nitschke
authors.affiliation: Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS) and Departamento de Química Orgánica, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
authors.forename: M Eugenio
authors.initials: ME
authors.lastname: Vázquez
authors.affiliation: Department of Chemistry, The University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.
authors.forename: José L
authors.initials: JL
authors.lastname: Mascareñas
mesh_terms: D000818:Animals; D000838:Anions / Q000737:chemistry; D002462:Cell Membrane / Q000737:chemistry*; D002522:Chlorocebus aethiops; D046911:Macromolecular Substances / Q000737:chemistry*; D015394:Molecular Structure; D014709:Vero Cells
chemical_list: D000838:Anions; D046911:Macromolecular Substances