title: Blue Maize Extract Improves Blood Pressure, Lipid Profiles, and Adipose Tissue in High-Sucrose Diet-Induced Metabolic Syndrome in Rats.
abstract: The effect of blue maize extract in factors related to metabolic syndrome (MS) in Wistar rats was investigated. Total polyphenols, monomeric anthocyanins, and antioxidant activity were analyzed in blue maize. MS was induced in Wistar rats fed with high-sucrose (HS) diet for 12 weeks. During a period of 4 weeks, blue maize extract was administrated to HS groups fed with high-sucrose and high-cholesterol-high-sucrose (HS+C) diets. In the blue maize extract administered by orogastric cannulation, the levels of total polyphenols and anthocyanins were 9.97 and 2.92 mg/kg of weight, respectively. HS diet administered during a period of 12 weeks increased significantly systolic blood pressure, serum triglycerides, and decreased high-density lipoprotein cholesterol (HDL-C), alterations related to the MS. Abdominal adipose tissue was only increased in the HS + C group. Blue maize extract administration enhanced HDL-C and decreased systolic blood pressure, serum triglycerides, total cholesterol, and epididymal adipose tissue weight. The blue maize may represent a promising nutraceutical option for the treatment of MS.
authors.affiliation: 1 Basic Sciences Institute, University of Veracruz , Xalapa, Veracruz, México .
authors.forename: Rosa Isela
authors.initials: RI
authors.lastname: Guzmán-Gerónimo
authors.affiliation: 1 Basic Sciences Institute, University of Veracruz , Xalapa, Veracruz, México .
authors.forename: Tania Margarita
authors.initials: TM
authors.lastname: Alarcón-Zavaleta
authors.affiliation: 2 Food Research and Development Unit (UNIDA), Technological Institute of Veracruz , Veracruz, México .
authors.forename: Rosa María
authors.initials: RM
authors.lastname: Oliart-Ros
authors.affiliation: 3 Biomedical Research Center, University of Veracruz , Xalapa, Veracruz, Mexico .
authors.forename: José Enrique
authors.initials: JE
authors.lastname: Meza-Alvarado
authors.affiliation: 4 Institute of Psychological Research, University of Veracruz, Xalapa , Veracruz, Mexico .
authors.forename: Socorro
authors.initials: S
authors.lastname: Herrera-Meza
authors.affiliation: 5 The Interdisciplinary Research Center for Integrated Regional Development, Oaxaca Unit, National Polytechnic Institute , Oaxaca, México .
authors.forename: José Luis
authors.initials: JL
authors.lastname: Chávez-Servia
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D006801:Humans; D050356:Lipid Metabolism / Q000187:drug effects*; D008297:Male; D024821:Metabolic Syndrome / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology*; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013395:Sucrose / Q000009:adverse effects* / Q000378:metabolism; D003313:Zea mays / Q000737:chemistry* / Q000378:metabolism
chemical_list: D010936:Plant Extracts; D013395:Sucrose
keywords: adiposity; dietary-induced hyperlipidemia; hypertension; phenolic compounds