title: Can Differences in Vascularity Serve as a Diagnostic Aid in Fibro-Osseous Lesions of the Jaws?
abstract: OBJECTIVE
  Different lesions in the fibro-osseous group share microscopic features; thus, establishing a definitive diagnosis based on microscopic features alone can be a challenge. There is a need for additional microscopic tools to aid in differentiating these lesions. This study compared parameters related to vascularity among 3 lesions in the fibro-osseous group: fibrous dysplasia (FD), central ossifying fibroma (COF), and cemento-osseous dysplasia (COD).
  
  
  METHODS
  This study was a cross-sectional analysis of biopsied lesions retrieved from 3 medical centers over a 14-year period. The primary predictor variables were the vascularity parameters (number, perimeter, and area). The outcome variables were diagnoses of FD, COF, and COD. Diagnosis was based on clinical, microscopic, and radiologic correlations. From each histopathologic slide, 5 representative fields were captured with a computerized digital camera. The number of blood vessels was counted, and the surface area and vascular perimeter were measured by tracing the perimeter of each vessel. Data were statistically analyzed using analysis of variance with logarithmic transformation and a Tukey adjustment.
  
  
  RESULTS
  Sixty-six cases were included in the study (26 in FD group, 26 in COF group, and 14 in COD group). The mean number of vessels showed only a tendency to be larger in the FD group compared with the COF and COD groups (5.4 ± 2.6, 3.7 ± 2.3, and 3.6 ± 1.7, respectively), but the results did not reach the threshold for significance. The mean vascular perimeter was 1,385.8 ± 859.2 pixels in the FD group and 742.6 ± 661.8 in COF group after logarithmic transformation (P = .012). The perimeter in the COD group was smaller (941.1 ± 502) compared with that in the FD group, but the difference did not reach the threshold for significance. The mean area was 25,061 ± 24,875.6 in the FD group and 11,773.8 ± 21,734.4 in the COF group after logarithmic transformation (P = .004). The perimeter in the COD group was smaller (13,011.1 ± 8,338.3) compared with the FD group, but the difference did not reach the threshold for significance.
  
  
  CONCLUSIONS
  The vascular content of the FD group was markedly higher than of the COF group. These vascular changes can aid in differentiating these lesions microscopically.
authors.affiliation: Resident, Department of Oral and Maxillofacial Surgery, Rabin Medical Center, Petach-Tikva, Israel. Electronic address: Tom_sh01@walla.co.il.
authors.forename: Tom
authors.initials: T
authors.lastname: Shmuly
authors.affiliation: Senior, Department of Oral and Maxillofacial Surgery, Rabin Medical Center, Petach-Tikva; Professor, Department of Oral and Maxillofacial Surgery, Goldschleger School of Dental Medicine, Tel-Aviv University, Tel-Aviv, Israel.
authors.forename: Dror M
authors.initials: DM
authors.lastname: Allon
authors.affiliation: Professor and Head, Department of Oral Pathology and Medicine, Goldschleger School of Dental Medicine, Tel-Aviv University, Tel-Aviv, Israel.
authors.forename: Marilena
authors.initials: M
authors.lastname: Vered
authors.affiliation: Head, Department of Oral and Maxillofacial Surgery, Rabin Medical Center, Petach-Tikva; Professor and Head, Department of Oral and Maxillofacial Surgery, Goldschleger School of Dental Medicine, Tel-Aviv University, Tel-Aviv, Israel.
authors.forename: Gavriel
authors.initials: G
authors.lastname: Chaushu
authors.affiliation: Head, Unit of Oral and Maxillofacial Surgery, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Shlomi
authors.affiliation: Head of Oral Pathology Service, Institute of Pathology, Rabin Medical Center, Petach-Tikva; Head of Oral Pathology Service, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel. Clinical Professor, Department of Oral Pathology and Medicine, Goldschleger School of Dental Medicine, and Clinical Professor, Department of Pathology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
authors.forename: Ilana
authors.initials: I
authors.lastname: Kaplan
mesh_terms: D000328:Adult; D001706:Biopsy; D002485:Cementoma / Q000098:blood supply* / Q000175:diagnosis*; D003430:Cross-Sectional Studies; D005260:Female; D018214:Fibroma, Ossifying / Q000098:blood supply* / Q000175:diagnosis*; D005357:Fibrous Dysplasia of Bone / Q000175:diagnosis*; D006801:Humans; D007571:Jaw Diseases / Q000175:diagnosis*; D007573:Jaw Neoplasms / Q000098:blood supply* / Q000175:diagnosis*; D008297:Male