title: Breast Cancer Following Radiation for Hodgkin Lymphoma: Clinical Scenarios and Risk-Reducing Strategies.
abstract: Since most patients with Hodgkin lymphoma survive their disease, long-term issues such as development of second primary malignancies arise, especially in patients treated with multimodal therapy including radiation therapy plus chemotherapy. The risk of breast cancer is significantly elevated in women exposed to high-dose ionizing radiation to the chest before age 40. The case of a 48-year-old patient with a lump in her right breast is presented as a clinical scenario in this article. We review available strategies for screening and risk reduction through chemoprevention or risk-reducing surgery, as well as challenges for management of breast cancer in patients with prior exposure to radiation for Hodgkin lymphoma. The Children's Oncology Group clinical practice guidelines for long-term follow-up care of pediatric cancer survivors provide recommendations that have been endorsed by American and European oncologists.
authors.forename: Linda
authors.initials: L
authors.lastname: Overholser
authors.forename: Elena
authors.initials: E
authors.lastname: Shagisultanova
authors.forename: Rachel A
authors.initials: RA
authors.lastname: Rabinovitch
authors.forename: Nicole
authors.initials: N
authors.lastname: Kounalakis
authors.forename: Jennifer
authors.initials: J
authors.lastname: Diamond
authors.forename: Christina A
authors.initials: CA
authors.lastname: Finlayson
authors.forename: Christine M
authors.initials: CM
authors.lastname: Fisher
authors.forename: Peter
authors.initials: P
authors.lastname: Kabos
authors.forename: Anthony D
authors.initials: AD
authors.lastname: Elias
authors.forename: Virginia F
authors.initials: VF
authors.lastname: Borges
authors.forename: Jose
authors.initials: J
authors.lastname: Mayordomo
mesh_terms: D001943:Breast Neoplasms / Q000209:etiology / Q000517:prevention & control*; D005260:Female; D006689:Hodgkin Disease / Q000532:radiotherapy*; D006801:Humans; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000517:prevention & control*; D016609:Neoplasms, Second Primary / Q000209:etiology / Q000517:prevention & control*; D040242:Risk Reduction Behavior