title: Development and validation of a multiclass method for the quantification of veterinary drug residues in honey and royal jelly by liquid chromatography-tandem mass spectrometry.
abstract: The aim of this study was to develop an analytical method for the analysis of a wide range of veterinary drugs in honey and royal jelly. A modified sample preparation procedure based on the quick, easy, cheap, effective, rugged and safe (QuEChERS) method was developed, followed by liquid chromatography tandem mass spectrometry determination. Use of the single sample preparation method for analysis of 42 veterinary drugs becomes more valuable because honey and royal jelly belong to completely different complex matrices. Another main advantage of the proposed method is its ability to identify and quantify 42 veterinary drugs with higher sensitivity than reference methods of China. This work has shown that the reported method was demonstrated to be convenient and reliable for the quick monitoring of veterinary drugs in honey and royal jelly samples.
authors.affiliation: Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, Beijing 100093, PR China; Bee Product Quality Supervision and Testing Center, Ministry of Agriculture, Beijing 100093, PRChina; Laboratory of Risk Assessment for Quality and Safety of Bee Products, Ministry of Agriculture, Beijing 100093, PRChina.
authors.forename: Yue
authors.initials: Y
authors.lastname: Jin
authors.affiliation: Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, Beijing 100093, PR China; Bee Product Quality Supervision and Testing Center, Ministry of Agriculture, Beijing 100093, PRChina; Laboratory of Risk Assessment for Quality and Safety of Bee Products, Ministry of Agriculture, Beijing 100093, PRChina.
authors.forename: Jinzhen
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, Beijing 100093, PR China; Bee Product Quality Supervision and Testing Center, Ministry of Agriculture, Beijing 100093, PRChina; Laboratory of Risk Assessment for Quality and Safety of Bee Products, Ministry of Agriculture, Beijing 100093, PRChina.
authors.forename: Wen
authors.initials: W
authors.lastname: Zhao
authors.affiliation: Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, Beijing 100093, PR China.
authors.forename: Wenwen
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, Beijing 100093, PR China; Bee Product Quality Supervision and Testing Center, Ministry of Agriculture, Beijing 100093, PRChina; Laboratory of Risk Assessment for Quality and Safety of Bee Products, Ministry of Agriculture, Beijing 100093, PRChina.
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.affiliation: Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, Beijing 100093, PR China; Bee Product Quality Supervision and Testing Center, Ministry of Agriculture, Beijing 100093, PRChina; Laboratory of Risk Assessment for Quality and Safety of Bee Products, Ministry of Agriculture, Beijing 100093, PRChina. Electronic address: zhoujinhui@caas.cn.
authors.forename: Jinhui
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, Beijing 100093, PR China; Bee Product Quality Supervision and Testing Center, Ministry of Agriculture, Beijing 100093, PRChina; Laboratory of Risk Assessment for Quality and Safety of Bee Products, Ministry of Agriculture, Beijing 100093, PRChina.
authors.forename: Yi
authors.initials: Y
authors.lastname: Li
mesh_terms: D000818:Animals; D001516:Bees; D002681:China; D002853:Chromatography, Liquid / Q000379:methods*; D004350:Drug Residues / Q000032:analysis*; D005227:Fatty Acids / Q000032:analysis*; D005506:Food Contamination; D006722:Honey / Q000032:analysis*; D053719:Tandem Mass Spectrometry / Q000379:methods*; D019155:Veterinary Drugs / Q000032:analysis*; D000099219:Royal Jelly
chemical_list: D005227:Fatty Acids; D019155:Veterinary Drugs; D000099219:Royal Jelly
keywords: HPLC–MS/MS; Honey; Multiclass residue; QuEChERS; Royal jelly; Veterinary drug