title: Role of ABC transporters in the pathology of Alzheimer's disease.
abstract: The ATP-binding cassette (ABC) transporter superfamily is a large family of proteins that transport specific molecules across membranes. These proteins are associated with both cholesterol metabolism and Alzheimer's disease (AD). Cholesterol homeostasis has a key role in AD, and ABC transporters are important mediators of lipid transportation. Emerging evidence suggests that decreased expression and hypofunction of ABC transporters are crucial to the occurrence and development of AD. In the present article, we review the current knowledge regarding ABC transporters and speculate on their role in the pathogenesis of AD.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhao
authors.forename: Deren
authors.initials: D
authors.lastname: Hou
authors.forename: Xialu
authors.initials: X
authors.lastname: Feng
authors.forename: Fangbo
authors.initials: F
authors.lastname: Lin
authors.forename: Jing
authors.initials: J
authors.lastname: Luo
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000378:metabolism*; D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology*; D000818:Animals; D001921:Brain / Q000378:metabolism / Q000473:pathology*; D002784:Cholesterol / Q000378:metabolism; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D050356:Lipid Metabolism / Q000502:physiology*
chemical_list: D018528:ATP-Binding Cassette Transporters; D002784:Cholesterol