title: Evaluation of ovarian reserve using anti-müllerian hormone and antral follicle count in Sjögren's syndrome: Preliminary study.
abstract: OBJECTIVE
  The aim of this study was to determine ovarian reserve status using anti-müllerian hormone (AMH) level and antral follicle count (AFC) in patients with Sjögren's syndrome (SS).
  
  
  METHODS
  Twenty-four women with SS diagnosed according to the classification criteria proposed by the American-European Consensus Group and 25 healthy women as controls were enrolled in this study. Ovarian reserve was assessed on clinical findings, AFC, and serum AMH and reproductive hormone levels.
  
  
  RESULTS
  Compared with the healthy controls, in the SS patients, the duration of menstrual cycle was significantly shorter (P = 0.043); serum AMH (P = 0.001) and AFC (P = 0.001) were significantly lower, and serum luteinizing hormone (LH) was significantly higher (P = 0.019). The right (P = 0.555) and left ovarian (P = 0.386) volumes were also lower but this did not reach statistical significance. Serum follicle-stimulating hormone (P = 0.327), estradiol (P = 0.241), and prolactin (P = 0.55) were similar between the two groups.
  
  
  CONCLUSIONS
  Ovarian reserve may be reduced in SS patients. For the assessment of ovarian reserve, serum AMH and ovarian AFC with serum LH may be useful. Further studies with long-term follow-up are required to determine the course of ovarian reserve abnormalities and best possible biomarkers of reduced ovarian reserve in SS patients.
authors.affiliation: Department of Obstetrics and Gynecology, Cumhuriyet University School of Medicine, Sivas, Turkey.
authors.forename: Savas
authors.initials: S
authors.lastname: Karakus
authors.affiliation: Department of Rheumatology, Cumhuriyet University School of Medicine, Sivas, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Sahin
authors.affiliation: Department of Rheumatology, Cumhuriyet University School of Medicine, Sivas, Turkey.
authors.forename: Yunus
authors.initials: Y
authors.lastname: Durmaz
authors.affiliation: Department of Biochemistry, Cumhuriyet University School of Medicine, Sivas, Turkey.
authors.forename: Huseyin
authors.initials: H
authors.lastname: Aydin
authors.affiliation: Department of Obstetrics and Gynecology, Cumhuriyet University School of Medicine, Sivas, Turkey.
authors.forename: Caglar
authors.initials: C
authors.lastname: Yildiz
authors.affiliation: Department of Obstetrics and Gynecology, Cumhuriyet University School of Medicine, Sivas, Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Akkar
authors.affiliation: Department of Otolaryngology, Cumhuriyet University School of Medicine, Sivas, Turkey.
authors.forename: Mansur
authors.initials: M
authors.lastname: Dogan
authors.affiliation: Department of Rheumatology, Cumhuriyet University School of Medicine, Sivas, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Cengiz
authors.affiliation: Department of Obstetrics and Gynecology, Cumhuriyet University School of Medicine, Sivas, Turkey.
authors.forename: Meral
authors.initials: M
authors.lastname: Cetin
authors.affiliation: Department of Obstetrics and Gynecology, Cumhuriyet University School of Medicine, Sivas, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Cetin
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D005260:Female; D006801:Humans; D006080:Ovarian Follicle; D065851:Ovarian Reserve; D012859:Sjogren's Syndrome / Q000097:blood* / Q000503:physiopathology*
chemical_list: D054304:Anti-Mullerian Hormone
keywords: Sjögren's syndrome; anti-müllerian hormone; ovarian reserve