title: Role of nanostructured aggregation of chitosan derivatives on [5-methionine]enkephalin affinity.
abstract: Affinities of quaternary ammonium-chitosan conjugates, their thiolated derivatives and corresponding nanostructured aggregates towards the hydrophilic drug [5-methionine]enkephalin were compared by Nuclear Magnetic Resonance (NMR) spectroscopic methods based on proton selective relaxation rate measurements. Nanoaggregates showed enhanced drug affinity in comparison with corresponding polymers, especially in the case of thiolated systems.
authors.affiliation: Università di Pisa, Dipartimento di Chimica e Chimica Industriale, Via Giuseppe Moruzzi 13, 56124 Pisa, Italy. Electronic address: federica.aiello87@gmail.com.
authors.forename: Federica
authors.initials: F
authors.lastname: Aiello
authors.affiliation: Università di Pisa, Dipartimento di Chimica e Chimica Industriale, Via Giuseppe Moruzzi 13, 56124 Pisa, Italy. Electronic address: federica.balzano@unipi.it.
authors.forename: Federica
authors.initials: F
authors.lastname: Balzano
authors.affiliation: Università di Pisa, Dipartimento di Chimica e Chimica Industriale, Via Giuseppe Moruzzi 13, 56124 Pisa, Italy. Electronic address: lucarpita@hotmail.it.
authors.forename: Luca
authors.initials: L
authors.lastname: Carpita
authors.affiliation: Università di Pisa, Dipartimento di Farmacia, Via Bonanno Pisano 6, 56126 Pisa, Italy. Electronic address: angyfab@gmail.com.
authors.forename: Angela
authors.initials: A
authors.lastname: Fabiano
authors.affiliation: Università di Pisa, Dipartimento di Farmacia, Via Bonanno Pisano 6, 56126 Pisa, Italy. Electronic address: ylenia.zambito@unipi.it.
authors.forename: Ylenia
authors.initials: Y
authors.lastname: Zambito
authors.affiliation: Università di Pisa, Dipartimento di Chimica e Chimica Industriale, Via Giuseppe Moruzzi 13, 56124 Pisa, Italy. Electronic address: gloria.uccello.barretta@unipi.it.
authors.forename: Gloria
authors.initials: G
authors.lastname: Uccello Barretta
mesh_terms: D048271:Chitosan / Q000737:chemistry*; D004744:Enkephalin, Methionine / Q000737:chemistry*; D049329:Nanostructures
chemical_list: D004744:Enkephalin, Methionine; D048271:Chitosan
keywords: Chitosan conjugates; Nanoparticles; Nuclear magnetic resonance; Selective relaxation rate; [5-Methionine]enkephalin