title: [Three cases of de novo multiple myeloma after kidney transplantation].
abstract: Light chain-associated kidney compromise is frequent in patients with monoclonal gammopathies; it affects the glomeruli or the tubules, and its most common cause is multiple myeloma. It may develop after a kidney transplant due to recurrence of a preexisting multiple myeloma or it can be a de novo disease manifesting as graft dysfunction and proteinuria. A kidney biopsy is always necessary to confirm the diagnosis.We describe three cases of kidney graft dysfunction due to multiple myeloma in patients without presence of the disease before the transplant.
authors.affiliation: Unidad de Nefrología y Trasplante Renal, Hospital Pablo Tobón Uribe, Universidad de Antioquia, Medellín, Colombia. johnfredynieto@gmail.com.
authors.forename: John Fredy
authors.initials: JF
authors.lastname: Nieto-Ríos
authors.forename: Mónica
authors.initials: M
authors.lastname: Zuluaga
authors.forename: Lina María
authors.initials: LM
authors.lastname: Serna
authors.forename: Arbey
authors.initials: A
authors.lastname: Aristizábal
authors.forename: Catalina
authors.initials: C
authors.lastname: Ocampo-Kohn
authors.forename: Kenny Mauricio
authors.initials: KM
authors.lastname: Gálvez
authors.forename: Adriana Alejandra
authors.initials: AA
authors.lastname: Flórez
authors.forename: Gustavo
authors.initials: G
authors.lastname: Zuluaga
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D016026:Bone Marrow Transplantation; D003131:Combined Modality Therapy; D017809:Fatal Outcome; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000032:analysis; D007166:Immunosuppressive Agents / Q000009:adverse effects; D007676:Kidney Failure, Chronic / Q000601:surgery; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D009194:Myeloma Proteins / Q000032:analysis; D055031:Primary Graft Dysfunction / Q000209:etiology*; D011507:Proteinuria / Q000209:etiology
chemical_list: D007147:Immunoglobulin Light Chains; D007166:Immunosuppressive Agents; D009194:Myeloma Proteins
keywords: kidney diseases; kidney transplantation; multiple myeloma; paraproteinemias