title: Meta-Analysis of the Relationship between TNF-α (-308G/A) and IL-10 (-819C/T) Gene Polymorphisms and Susceptibility to Dengue.
abstract: OBJECTIVE
  This study determined whether tumor necrosis factor alpha (TNF-α) and Interleukin-10 (IL-10) polymorphisms are associated with susceptibility to dengue.
  
  
  METHODS
  a systematic review with meta-analysis was conducted of the associations between the TNF-α (-308G/A) and IL-10 (-819C/T) polymorphisms and dengue.
  
  
  RESULTS
  A total of eight case-controls studies involving 384 individuals with symptomatic dengue, 571 individuals with dengue hemorrhagic fever, and 995 healthy controls were considered in the meta-analysis. There was no significant association between TNF-α (-308G/A) and IL-10 (-819C/T) polymorphism and dengue in overall population. However, stratifying meta-analysis by groups, the meta-analysis revealed association between the TNF-α -308 G/G (OR: 1.62, CI: 1.02-2.57, p = 0.04) genotype and allele G (OR: 1.62, CI: 1.04-2.55, p = 0.03) that confers susceptibility to symptomatic dengue, while the TNF-α -308 G/A genotype (OR: 0.69, CI = 0.39-0.99, p = 0.04) and allele A (OR: 0.64, CI: 0.41-1.00, p = 0.05) confers protection to symptomatic dengue. No difference was observed for the TNF-α (-308) and IL-10 (-819C/T) polymorphisms in the comparisons of hemorrhagic dengue versus control and hemorrhagic dengue versus symptomatic dengue.
  
  
  CONCLUSIONS
  This meta-analysis showed that TNF-α (-308) polymorphism is associated with dengue symptomatic susceptibility.
authors.affiliation: a Institute of Biological and Health Sciences, Federal University of Alagoas , Maceio , Brazil.|b Laboratory of Molecular Biology and Gene Expression, Federal University of Alagoas , Maceio , Brazil.
authors.forename: Ana Caroline Melo Dos
authors.initials: AC
authors.lastname: Santos
authors.affiliation: b Laboratory of Molecular Biology and Gene Expression, Federal University of Alagoas , Maceio , Brazil.
authors.forename: Edilson Leite
authors.initials: EL
authors.lastname: de Moura
authors.affiliation: b Laboratory of Molecular Biology and Gene Expression, Federal University of Alagoas , Maceio , Brazil.
authors.forename: Jean Moisés
authors.initials: JM
authors.lastname: Ferreira
authors.affiliation: b Laboratory of Molecular Biology and Gene Expression, Federal University of Alagoas , Maceio , Brazil.
authors.forename: Barbara Rayssa Correia Dos
authors.initials: BR
authors.lastname: Santos
authors.affiliation: c Nursing Department , Federal University of Alagoas , Maceio , Brazil.
authors.forename: Verônica de Medeiros
authors.initials: VM
authors.lastname: Alves
authors.affiliation: b Laboratory of Molecular Biology and Gene Expression, Federal University of Alagoas , Maceio , Brazil.
authors.forename: Karol Fireman
authors.initials: KF
authors.lastname: de Farias
authors.affiliation: a Institute of Biological and Health Sciences, Federal University of Alagoas , Maceio , Brazil.|b Laboratory of Molecular Biology and Gene Expression, Federal University of Alagoas , Maceio , Brazil.
authors.forename: Elaine Virgínia Martins
authors.initials: EV
authors.lastname: de Souza Figueiredo
mesh_terms: D016022:Case-Control Studies; D003715:Dengue / Q000235:genetics*; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: C508609:IL10 protein, human; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10
keywords: Dengue; TNF-alpha; interleukin-10; meta-analysis; polymorphism