title: The impact of KIR2DS4 gene on clinical outcome after hematopoietic stem cell transplantation.
abstract: Killer cell immunoglobulin-like receptors (KIR) are a family of inhibitory/activating receptors expressed on NK cells. Interactions of KIR receptors with KIR ligands have been shown to modify hematopoietic stem cell transplantation (HSCT) outcome. The aim of this research was to determine the KIR2DS4 allele variants distribution among 111 patients with different hematological malignancy who underwent HSCT and their donors, and to evaluate KIR2DS4 alleles' impact on HSCT outcome. The KIR gene frequency analysis showed a significantly higher incidence of full-length KIR2DS4 alleles among patients. The impact of KIR2DS4 alleles on transplantation outcomes revealed that donors' full-length KIR2DS4 alleles is associated with lower overall survival rates, higher risk of GVHD and higher relapse incidence. The expression of full-length KIR2DS4 allele variants may contribute to a worse clinical outcome after HSCT. KIR typing for KIR2DS4 could be used as an additional criterion for selecting suitable donors in cases when more than one HLA identical donor is identified for a specific patient.
authors.affiliation: Tissue Typing Centre, Clinical Department for Transfusion Medicine and Transplantation Biology, University Hospital Centre Zagreb, Zagreb, Croatia. Electronic address: mburek@kbc-zagreb.hr.
authors.forename: Marija
authors.initials: M
authors.lastname: Burek Kamenaric
authors.affiliation: Tissue Typing Centre, Clinical Department for Transfusion Medicine and Transplantation Biology, University Hospital Centre Zagreb, Zagreb, Croatia. Electronic address: katarinastingl@gmail.com.
authors.forename: Katarina
authors.initials: K
authors.lastname: Stingl Jankovic
authors.affiliation: Tissue Typing Centre, Clinical Department for Transfusion Medicine and Transplantation Biology, University Hospital Centre Zagreb, Zagreb, Croatia. Electronic address: zgrubic@kbc-zagreb.hr.
authors.forename: Zorana
authors.initials: Z
authors.lastname: Grubic
authors.affiliation: Department of Hematology, Internal Clinic, University Hospital Center Zagreb, Zagreb, Croatia.
authors.forename: Ranka
authors.initials: R
authors.lastname: Serventi Seiwerth
authors.affiliation: Tissue Typing Centre, Clinical Department for Transfusion Medicine and Transplantation Biology, University Hospital Centre Zagreb, Zagreb, Croatia. Electronic address: marija.maskalan@kbc-zagreb.hr.
authors.forename: Marija
authors.initials: M
authors.lastname: Maskalan
authors.affiliation: Department of Hematology, Internal Clinic, University Hospital Center Zagreb, Zagreb, Croatia.
authors.forename: Damir
authors.initials: D
authors.lastname: Nemet
authors.affiliation: Croatian Bone Marrow Donor Registry, University Hospital Center Zagreb, Zagreb, Croatia. Electronic address: mmikulic@kbc-zagreb.hr.
authors.forename: Mirta
authors.initials: M
authors.lastname: Mikulic
authors.affiliation: Tissue Typing Centre, Clinical Department for Transfusion Medicine and Transplantation Biology, University Hospital Centre Zagreb, Zagreb, Croatia. Electronic address: rzunec@kbc-zagreb.hr.
authors.forename: Renata
authors.initials: R
authors.lastname: Zunec
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D002648:Child; D002675:Child, Preschool; D046148:Donor Selection; D005260:Female; D005787:Gene Frequency; D006086:Graft vs Host Disease / Q000235:genetics; D006239:Haplotypes; D019337:Hematologic Neoplasms / Q000235:genetics* / Q000276:immunology; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007223:Infant; D007694:Killer Cells, Natural; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000235:genetics* / Q000276:immunology; D054340:Receptors, KIR / Q000235:genetics / Q000276:immunology*; D055815:Young Adult
chemical_list: C473953:KIR2DS4 protein, human; D054340:Receptors, KIR
keywords: Croatian population; Hematopoietic stem cell transplantation (HSCT); KIR2DS4 alleles; Killer cell immunoglobulin-like receptors (KIR)