title: Prognostic value of MMP-2 for patients with ovarian epithelial carcinoma: a systematic review and meta-analysis.
abstract: BACKGROUND
  The reported roles of matrix metalloproteinase 2 (MMP-2) on the prognosis of patients with epithelial ovarian cancers (EOCs) are inconsistent.
  
  
  OBJECTIVE
  This meta-analysis was performed to evaluate the prognostic significance of MMP-2 for patients with EOCs by analyzing 11 studies.
  
  
  METHODS
  We systematically searched articles in the Cochrane Library, Pubmed, Embase, China National Knowledge Infrastructure (CNKI), Wanfang Database, and Chinese Biological Medical (CBM) Database, updated to February 1st2015, with the following search terms: ovarian neoplasm OR ovarian tumor OR ovarian carcinoma OR ovarian malignance OR ovarian cancer AND matrix metalloproteinase-2 OR MMP-2.
  
  
  RESULTS
  A total of 11 studies involving 1058 patients with EOCs were in accordance with the inclusion criteria. The pooled HR was 1.09 (95% CI 0.32-1.86, p = 0.006) in patients with overexpression of stromal MMP-2 with significant heterogeneity (I2= 53.1%, p = 0.074) between studies. For patients with MMP-2 overexpression in tumor cells, the pooled HR was 1.42 (95% CI 1.14-1.70, p = 0.000) with no significant heterogeneity (I2= 43.4%, p = 0.078) between studies. Sensitivity analyses were stable.
  
  
  CONCLUSIONS
  MMP-2 overexpression in tumor cells rather than stroma was significantly associated with poor prognosis in patient with endothelial ovarian cancer; however, the result remains to be confirmed with additional high-quality studies.
authors.affiliation: Shandong Provincial Hospital Affiliated to Shandong University, No. 324, Road Jing Wu Wei Qi, Jinan, 250021, Shandong, China.
authors.forename: Honglei
authors.initials: H
authors.lastname: Jia
authors.affiliation: Qilu Hospital Affiliated to Shandong University, Jinan, 250012, Shandong, China.
authors.forename: Qingyu
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Shandong Provincial Hospital Affiliated to Shandong University, No. 324, Road Jing Wu Wei Qi, Jinan, 250021, Shandong, China.
authors.forename: Fanxiao
authors.initials: F
authors.lastname: Liu
authors.affiliation: Shandong Provincial Hospital Affiliated to Shandong University, No. 324, Road Jing Wu Wei Qi, Jinan, 250021, Shandong, China. cycsubmission618@sina.com.
authors.forename: Dongsheng
authors.initials: D
authors.lastname: Zhou
mesh_terms: D000077216:Carcinoma, Ovarian Epithelial; D005260:Female; D006801:Humans; D020778:Matrix Metalloproteinase 2 / Q000032:analysis*; D009375:Neoplasms, Glandular and Epithelial / Q000201:enzymology* / Q000401:mortality; D010051:Ovarian Neoplasms / Q000201:enzymology* / Q000401:mortality; D011379:Prognosis
chemical_list: C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2
keywords: MMP-2; Meta-analysis; Ovarian epithelial carcinoma; Prognostic value