title: Curcumin-Loaded Amine-Functionalized Mesoporous Silica Nanoparticles Inhibit α-Synuclein Fibrillation and Reduce Its Cytotoxicity-Associated Effects.
abstract: This study aimed to develop a drug carrier based on amine-functionalized mesoporous silica nanoparticles (AAS-MSNPs) for a poorly water-soluble drug, curcumin (CUR), and to study its effects on α-synuclein (α-Syn) fibrillation and cytotoxicity. Here, we show that AAS-MSNPs possess high values of loading efficiency and capacity (33.5% and 0.45 mg drug/mg MSNPs, respectively) for CUR. It is also revealed that α-Syn species interact strongly with the CUR-loaded AAS-MSNPs, leading to a significant inhibition of the fibrillation process. Furthermore, these samples reduce the toxic effects of CUR. However, drug-loaded AAS-MSNPs do not affect the cytotoxic properties of the formed fibrils considerably. In addition, CUR loaded onto AAS-MSNPs shows enhanced stability in comparison with that of the free drug. These remarkable properties introduce AAS-MSNPs as a promising tool for the formulation of poorly water-soluble drugs such as CUR.
authors.affiliation: Department of Industrial and Environmental Biotechnology, National Institute of Genetic Engineering and Biotechnology (NIGEB) , Tehran-Karaj Highway, Tehran 1497716316, Iran.|Department of Chemical and Petroleum Engineering, Sharif University of Technology , Azadi Avenue, Tehran 1136511155, Iran.
authors.forename: Nayere
authors.initials: N
authors.lastname: Taebnia
authors.affiliation: Department of Industrial and Environmental Biotechnology, National Institute of Genetic Engineering and Biotechnology (NIGEB) , Tehran-Karaj Highway, Tehran 1497716316, Iran.
authors.forename: Dina
authors.initials: D
authors.lastname: Morshedi
authors.affiliation: Department of Chemical and Petroleum Engineering, Sharif University of Technology , Azadi Avenue, Tehran 1136511155, Iran.
authors.forename: Soheila
authors.initials: S
authors.lastname: Yaghmaei
authors.affiliation: Department of Industrial and Environmental Biotechnology, National Institute of Genetic Engineering and Biotechnology (NIGEB) , Tehran-Karaj Highway, Tehran 1497716316, Iran.
authors.forename: Farhang
authors.initials: F
authors.lastname: Aliakbari
authors.affiliation: Department of Industrial and Environmental Biotechnology, National Institute of Genetic Engineering and Biotechnology (NIGEB) , Tehran-Karaj Highway, Tehran 1497716316, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Rahimi
authors.affiliation: Department of Industrial and Environmental Biotechnology, National Institute of Genetic Engineering and Biotechnology (NIGEB) , Tehran-Karaj Highway, Tehran 1497716316, Iran.
authors.forename: Ayyoob
authors.initials: A
authors.lastname: Arpanaei
mesh_terms: D000588:Amines; D000818:Animals; D003474:Curcumin / Q000737:chemistry*; D004337:Drug Carriers; D053758:Nanoparticles; D016716:PC12 Cells; D051381:Rats; D012822:Silicon Dioxide; D051844:alpha-Synuclein / Q000037:antagonists & inhibitors*
chemical_list: D000588:Amines; D004337:Drug Carriers; D051844:alpha-Synuclein; D012822:Silicon Dioxide; D003474:Curcumin