title: Expression of Extracellular Signal-regulated Kinase 5 and Ankyrin Repeat Domain 1 in Composite Pheochromocytoma and Ganglioneuroblastoma Detected Incidentally in the Adult Adrenal Gland.
abstract: Composite pheochromocytoma (cPC) is extremely rare, arising in the adrenal medulla as a mixture of PC and other tumors of neural origin. We herein report on a case of adrenal incidentaloma post-operatively diagnosed as cPC with ganglioneuroblastoma (GNBL). The PC component had 7 points on the PASS, a Ki-67 index of 5.1%, a focal absence of sustentacular cells, and no genetic aberrations in succinate dehydrogenase subunit B. The GNBL component exhibited no N-myc amplification. Tumor cells of both components were stained positively for extracellular signal-regulated kinase 5 and ankyrin repeat domain 1. The aberrant activation of growth signaling may play a role in the marginal malignancy of cPC.
authors.affiliation: Department of Urology, Yamagata University Faculty of Medicine, Japan.
authors.forename: Shinta
authors.initials: S
authors.lastname: Suenaga
authors.forename: Osamu
authors.initials: O
authors.lastname: Ichiyanagi
authors.forename: Hiromi
authors.initials: H
authors.lastname: Ito
authors.forename: Sei
authors.initials: S
authors.lastname: Naito
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Kato
authors.forename: Akira
authors.initials: A
authors.lastname: Nagaoka
authors.forename: Tomoya
authors.initials: T
authors.lastname: Kato
authors.forename: Mitsunori
authors.initials: M
authors.lastname: Yamakawa
authors.forename: Yutaro
authors.initials: Y
authors.lastname: Obara
authors.forename: Norihiko
authors.initials: N
authors.lastname: Tsuchiya
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D000313:Adrenal Medulla / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology; D000315:Adrenalectomy; D005260:Female; D005500:Follow-Up Studies; D018305:Ganglioneuroblastoma / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D006801:Humans; D033162:Incidental Findings; D008875:Middle Aged; D048054:Mitogen-Activated Protein Kinase 7 / Q000378:metabolism*; D009124:Muscle Proteins / Q000378:metabolism*; D009687:Nuclear Proteins / Q000378:metabolism*; D010673:Pheochromocytoma / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D012097:Repressor Proteins / Q000378:metabolism*; D015398:Signal Transduction; D013385:Succinate Dehydrogenase / Q000235:genetics; D016896:Treatment Outcome
chemical_list: C491304:ANKRD1 protein, human; D009124:Muscle Proteins; D009687:Nuclear Proteins; D012097:Repressor Proteins; C491545:SDHD protein, human; D013385:Succinate Dehydrogenase; C481581:MAPK7 protein, human; D048054:Mitogen-Activated Protein Kinase 7