title: Stimuli-responsive nanocomposites for magnetic targeting synergistic multimodal therapy and T1/T2-weighted dual-mode imaging.
abstract: Anticancer drug doxorubicin hydrochloride (DOX)-loaded photothermal nanocomposite MnFe2O4@mSiO2with magnetic targeting and T1/T2-weighted dual-mode magnetic resonance imaging of MnFe2O4core and NIR/pH-coupling sensitive mesoporous silica shell nanocarriers was designed and synthesized successfully. The anticancer drug DOX can be absorbed into mesoporous layer of MnFe2O4@mSiO2nanocomposite, which shows obvious photothermal/chemo dual-modal synergistic therapies triggered by NIR/pH. Under 808 nm irradiation, MnFe2O4can transform light into thermo, which can not only ablate tumor cells directly but also promote chemotherapy drugs releasing from mesoporous layer to kill tumor cells. The lower pH can also promote DOX releasing from mesoporous layer to enhance tumor inhibitory effect. It is confirmed that biocompatible DOX-MnFe2O4@mSiO2nanocomposites can act as a potential multifunctional platform for effective magnetic targeting photothermal/chemo dual-modal synergistic therapies with enhanced anti-tumor efficacy and T1/T2-weighted dual-mode magnetic resonance imaging (MRI) applications in vivo.
authors.affiliation: State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, PR China; University of the Chinese Academy of Sciences, Beijing, PR China.
authors.forename: Yinyin
authors.initials: Y
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, PR China; University of the Chinese Academy of Sciences, Beijing, PR China.
authors.forename: Xiaoran
authors.initials: X
authors.lastname: Deng
authors.affiliation: State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, PR China. Electronic address: cxli@ciac.ac.cn.
authors.forename: Chunxia
authors.initials: C
authors.lastname: Li
authors.affiliation: State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, PR China; University of the Chinese Academy of Sciences, Beijing, PR China.
authors.forename: Fei
authors.initials: F
authors.lastname: He
authors.affiliation: State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, PR China; University of the Chinese Academy of Sciences, Beijing, PR China.
authors.forename: Bei
authors.initials: B
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, PR China.
authors.forename: Zhiyao
authors.initials: Z
authors.lastname: Hou
authors.affiliation: State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, PR China.
authors.forename: Ziyong
authors.initials: Z
authors.lastname: Cheng
authors.affiliation: School of Physical & Mathematical Sciences, Nanyang Technological University, Singapore.
authors.forename: Bengang
authors.initials: B
authors.lastname: Xing
authors.affiliation: State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, PR China. Electronic address: jlin@ciac.ac.cn.
authors.forename: Jun
authors.initials: J
authors.lastname: Lin
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D003131:Combined Modality Therapy / Q000379:methods; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000627:therapeutic use; D004317:Doxorubicin / Q000008:administration & dosage* / Q000627:therapeutic use; D016503:Drug Delivery Systems / Q000379:methods*; D005290:Ferric Compounds / Q000737:chemistry* / Q000627:therapeutic use; D006367:HeLa Cells; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods; D060526:Magnetic Fields; D008279:Magnetic Resonance Imaging / Q000379:methods*; D017895:Manganese Compounds / Q000737:chemistry* / Q000627:therapeutic use; D051379:Mice; D053761:Nanocomposites / Q000737:chemistry* / Q000627:therapeutic use / Q000648:ultrastructure; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000628:therapy*; D010789:Phototherapy / Q000379:methods; D012822:Silicon Dioxide / Q000737:chemistry* / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D005290:Ferric Compounds; D017895:Manganese Compounds; C551151:manganese ferrite; D012822:Silicon Dioxide; D004317:Doxorubicin
keywords: Dual-mode imaging; Magnetic targeting; Stimuli-responsive; Synergistic therapy