title: Measuring blood-brain barrier penetration using the NeuroCart, a CNS test battery.
abstract: To systematically study the pharmacodynamics of a CNS drug early in the development process, we developed and validated a battery of drug-sensitive CNS tests, which we call NeuroCart. Using this test battery, data-intensive phase 1 studies in healthy subjects can be performed to demonstrate the specific, time- and dose-dependent, neurophysiological and/or neuropsychological effects of a compound, thereby confirming whether the test compound reaches its intended target in the CNS - or does not reach its intended target. We use this test battery to demonstrate that a compound passes the blood-brain barrier.
authors.affiliation: Centre for Human Drug Research, Zernikedreef 8, 2333CL Leiden, The Netherlands. Electronic address: ggroeneveld@chdr.nl.
authors.forename: Geert Jan
authors.initials: GJ
authors.lastname: Groeneveld
authors.affiliation: Centre for Human Drug Research, Zernikedreef 8, 2333CL Leiden, The Netherlands.
authors.forename: Justin Luke
authors.initials: JL
authors.lastname: Hay
authors.affiliation: Centre for Human Drug Research, Zernikedreef 8, 2333CL Leiden, The Netherlands.
authors.forename: Johannes Marinus
authors.initials: JM
authors.lastname: Van Gerven
mesh_terms: D001692:Biological Transport; D001812:Blood-Brain Barrier / Q000378:metabolism*; D002491:Central Nervous System Agents / Q000493:pharmacokinetics / Q000494:pharmacology; D055808:Drug Discovery; D006801:Humans; D009483:Neuropsychological Tests
chemical_list: D002491:Central Nervous System Agents