title: Circulating tumor markers: harmonizing the yin and yang of CTCs and ctDNA for precision medicine.
abstract: Current trajectory of clinical care is heading in the direction of personalized medicine. In an ideal scenario, clinicians can obtain extensive diagnostic and prognostic information via minimally-invasive assays. Information available in the peripheral blood has the potential to bring us closer to this goal. In this review we highlight the contributions of circulating tumor cells and circulating tumor DNA and RNA (ctDNA/ctRNA) towards cancer therapeutic field. We discuss clinical relevance, summarize available and upcoming technologies, and hypothesize how future care could be impacted by a combined study.
authors.affiliation: Department of Pediatrics - Research, The University of Texas MD Anderson Cancer Center, Houston, USA.
authors.forename: I S
authors.initials: IS
authors.lastname: Batth
authors.affiliation: Department of Pediatrics - Research, The University of Texas MD Anderson Cancer Center, Houston, USA.
authors.forename: A
authors.initials: A
authors.lastname: Mitra
authors.affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA.
authors.forename: S
authors.initials: S
authors.lastname: Manier
authors.affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA.
authors.forename: I M
authors.initials: IM
authors.lastname: Ghobrial
authors.affiliation: Department of Gastrointestinal (GI) Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA.
authors.forename: D
authors.initials: D
authors.lastname: Menter
authors.affiliation: Department of Gastrointestinal (GI) Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA.
authors.forename: S
authors.initials: S
authors.lastname: Kopetz
authors.affiliation: Department of Pediatrics - Research, The University of Texas MD Anderson Cancer Center, Houston, USA.
authors.forename: S
authors.initials: S
authors.lastname: Li
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D000074141:Circulating Tumor DNA / Q000097:blood*; D004273:DNA, Neoplasm / Q000235:genetics; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000097:blood* / Q000235:genetics; D009360:Neoplastic Cells, Circulating / Q000378:metabolism*; D057285:Precision Medicine
chemical_list: D014408:Biomarkers, Tumor; D000074141:Circulating Tumor DNA; D004273:DNA, Neoplasm
keywords: cell free DNA; cell free RNA; circulating tumor DNA; circulating tumor RNA; circulating tumor cells; exosomes