title: Rapid hemostatic and mild polyurethane-urea foam wound dressing for promoting wound healing.
abstract: A novel rapid hemostatic and mild polyurethane-urea foam (PUUF) wound dressing was prepared by the particle leaching method and vacuum freeze-drying method using 4, 4-Methylenebis(cyclohexyl isocyanate), 4,4-diaminodicyclohexylmethane and poly (ethylene glycol) as raw materials. And X-ray diffraction (XRD), tensile test, differential scanning calorimetry (DSC) and thermogravimetry (TG) were used to its crystallinity, stress and strain behavior, and thermal properties, respectively. Platelet adhesion, fibrinogen adhesion and blood clotting were performed to evaluate its hemostatic effect. And H&E staining and Masson Trichrome staining were used to its wound healing efficacy. The results revealed the pore size of PUUF is 50-130μm, and its porosity is 71.01%. Porous PUUF exhibited good water uptake that was benefit to adsorb abundant wound exudates to build a regional moist environment beneficial for wound healing. The PUUF wound dressing exhibit better blood coagulation effect than commercial polyurethane dressing (CaduMedi). Though both PUUF and CaduMedi facilitated wound healing generating full re-epithelialization within 13days, PUUF was milder and lead to more slight inflammatory response than CaduMedi. In addition, PUUF wound dressing exhibited lower cytotoxicity than CaduMedi against NIH3T3 cells. Overall, porous PUUF represents a novel mild wound dressing with excellent water uptake, hemostatic effect and low toxicity, and it can promote wound healing and enhance re-epithelialization.
authors.affiliation: College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, PR China; Nanshan District Key lab for Biopolymers and Safety Evaluation, Shenzhen 518060, PR China; Shenzhen Key Laboratory of Polymer Science and Technology, Shenzhen 518060, PR China; Guangdong Research Center for Interfacial Engineering of Functional Materials, Shenzhen 518060, PR China.
authors.forename: Xiangyu
authors.initials: X
authors.lastname: Liu
authors.affiliation: College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, PR China; Nanshan District Key lab for Biopolymers and Safety Evaluation, Shenzhen 518060, PR China; Shenzhen Key Laboratory of Polymer Science and Technology, Shenzhen 518060, PR China; Guangdong Research Center for Interfacial Engineering of Functional Materials, Shenzhen 518060, PR China.
authors.forename: Yuqing
authors.initials: Y
authors.lastname: Niu
authors.affiliation: Multidisciplinary Research Center, Shantou University, Shantou, Guangdong 515063, PR China.
authors.forename: Kevin C
authors.initials: KC
authors.lastname: Chen
authors.affiliation: College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, PR China; Nanshan District Key lab for Biopolymers and Safety Evaluation, Shenzhen 518060, PR China; Shenzhen Key Laboratory of Polymer Science and Technology, Shenzhen 518060, PR China; Guangdong Research Center for Interfacial Engineering of Functional Materials, Shenzhen 518060, PR China. Electronic address: csg@szu.edu.cn.
authors.forename: Shiguo
authors.initials: S
authors.lastname: Chen
mesh_terms: D000818:Animals; D001458:Bandages; D001777:Blood Coagulation / Q000187:drug effects*; D006489:Hemostatic Techniques; D006801:Humans; D051379:Mice; D041681:NIH 3T3 Cells; D011140:Polyurethanes / Q000737:chemistry / Q000494:pharmacology; D016062:Porosity; D014508:Urea / Q000737:chemistry / Q000494:pharmacology; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D011140:Polyurethanes; D014508:Urea
keywords: Foam wound dressing; Histological assessment; Polyurethane-urea; Rapid hemostatic