title: Association of Serum Triglyceride Level and Gemfibrozil Consumption With Periodontal Status.
abstract: Hyperlipidemia is a major risk factor for cardiovascular diseases. Considering the suggested association between periodontal and cardiovascular diseases, this study sought to assess the association, if any, between serum triglyceride (TG) levels and gemfibrozil consumption with periodontal parameters.
  
  
  
  This cross-sectional study was conducted on 90 participants, including 30 individuals with a normal lipid profile (group H), 30 patients with hypertriglyceridemia and not on medication (group N), and 30 patients with hypertriglyceridemia and taking gemfibrozil over a 3-month period (group M). Periodontal parameters including probing depth (PD), clinical attachment level (CAL), bleeding on probing (BOP), and plaque index were measured at four sites of each tooth. Serum levels of total cholesterol (TC), TG, low-density lipoprotein, and high-density lipoprotein were measured.
  
  
  
  Mean values for PD and CAL in the two hypertriglyceridemic groups were significantly higher than those of the H group (P <0.001). After controlling for confounding variables, significant linear correlations were noted between PD and BOP, PD and TC, PD and TG, and CAL and TG in each group (P <0.01).
  
  
  
  Patients with hypertriglyceridemia had worse periodontal status than healthy controls. Patients with hypertriglyceridemia who were taking gemfibrozil did not show significant differences in CAL and PD compared with untreated patients with hypertriglyceridemia.
authors.affiliation: Department of Periodontics, Tehran Dental Branch, Islamic Azad University, Tehran, Iran.
authors.forename: Ferena
authors.initials: F
authors.lastname: Sayar
authors.affiliation: Department of Mathematics, South Tehran Branch, Islamic Azad University.
authors.forename: Nasrin
authors.initials: N
authors.lastname: Akhondi
authors.affiliation: Gastroenterology Department of Milad Hospital, Tehran, Iran.
authors.forename: Soltanali
authors.initials: S
authors.lastname: Fallah
authors.affiliation: Private practice, Tehran, Iran.
authors.forename: Amir Abbas
authors.initials: AA
authors.lastname: Moalemnia
authors.affiliation: Department of Periodontics, Tehran Dental Branch, Islamic Azad University, Tehran, Iran.
authors.forename: Azra
authors.initials: A
authors.lastname: Cheraghi
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D003774:Dental Plaque Index; D005260:Female; D015248:Gemfibrozil / Q000627:therapeutic use*; D006801:Humans; D015228:Hypertriglyceridemia / Q000150:complications / Q000188:drug therapy; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010510:Periodontal Diseases / Q000209:etiology*; D010512:Periodontal Index; D014280:Triglycerides / Q000097:blood*
chemical_list: D000960:Hypolipidemic Agents; D014280:Triglycerides; D015248:Gemfibrozil
keywords: Cardiovascular diseases; gemfibrozil; hyperlipidemias; hypertriglyceridemia; periodontal diseases; risk factors