title: [Progress of research on azole resistance inAspergillus fumigatus].
abstract: Being an important clinical fungal pathogen,Aspergillus(A.)fumigatuscan cause fatal invasive fungal infections. Azoles are the first line drugs in treating various Aspergillus-caused diseases. Worldwidely, reports related to azole resistance inA. fumigatushave been increasing which posing a threat on the effectiveness of clinically used azole and agricultural fungicides. Currently, it has become an important public health issue. In this review, we summarize findings from literature regarding the following areas: the occurrence of azole resistance inA. fumigatus, the molecular mechanisms of resistance, contributing factors for the emergence of azole resistance, evolution of resistant strains and related control and prevention measures.
authors.affiliation: Department of Hospital Infection Control, Institute of Disease Control and Prevention, Academy of Military Medical Science, Beijing 100071, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Hospital Infection Control, Institute of Disease Control and Prevention, Academy of Military Medical Science, Beijing 100071, China.
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Lu
authors.affiliation: Department of Bioinformatics, Institute of Biotechnology, Academy of Military Medical Science, Beijing 100071, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Jin
authors.affiliation: Department of Hospital Infection Control, Institute of Disease Control and Prevention, Academy of Military Medical Science, Beijing 100071, China.
authors.forename: L
authors.initials: L
authors.lastname: Han
authors.affiliation: Department of Infectious Disease, Institute of Disease Prevention and Control, Academy of Military Medical Science, Beijing 100071, China.
authors.forename: L Y
authors.initials: LY
authors.lastname: Huang
mesh_terms: D000935:Antifungal Agents; D001232:Aspergillus fumigatus; D001393:Azoles; D025141:Drug Resistance, Fungal; D006801:Humans
chemical_list: D000935:Antifungal Agents; D001393:Azoles