title: Disease drivers of aging.
abstract: It has long been known that aging, at both the cellular and organismal levels, contributes to the development and progression of the pathology of many chronic diseases. However, much less research has examined the inverse relationship-the contribution of chronic diseases and their treatments to the progression of aging-related phenotypes. Here, we discuss the impact of three chronic diseases (cancer, HIV/AIDS, and diabetes) and their treatments on aging, putative mechanisms by which these effects are mediated, and the open questions and future research directions required to understand the relationships between these diseases and aging.
authors.affiliation: National Institute on Aging, Bethesda, Maryland.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Hodes
authors.affiliation: National Institute on Aging, Bethesda, Maryland.
authors.forename: Felipe
authors.initials: F
authors.lastname: Sierra
authors.affiliation: Department of Biology, University of Alabama at Birmingham, Birmingham, Alabama.
authors.forename: Steven N
authors.initials: SN
authors.lastname: Austad
authors.affiliation: Department of Psychiatry, University of California, San Francisco, San Francisco, California.
authors.forename: Elissa
authors.initials: E
authors.lastname: Epel
authors.affiliation: Virginia Commonwealth University, Richmond, Virginia.
authors.forename: Gretchen N
authors.initials: GN
authors.lastname: Neigh
authors.affiliation: University of Colorado-Anschutz Medical Center, Aurora, Colorado.
authors.forename: Kristine M
authors.initials: KM
authors.lastname: Erlandson
authors.affiliation: Robert and Arlene Kogod Center on Aging and Department of Physical Medicine and Rehabilitation, Mayo Clinic College of Medicine, Rochester, Minnesota.
authors.forename: Marissa J
authors.initials: MJ
authors.lastname: Schafer
authors.affiliation: Robert and Arlene Kogod Center on Aging and Department of Physical Medicine and Rehabilitation, Mayo Clinic College of Medicine, Rochester, Minnesota.
authors.forename: Nathan K
authors.initials: NK
authors.lastname: LeBrasseur
authors.affiliation: Buck Institute for Research on Aging, Novato, California.
authors.forename: Christopher
authors.initials: C
authors.lastname: Wiley
authors.affiliation: Buck Institute for Research on Aging, Novato, California.
authors.forename: Judith
authors.initials: J
authors.lastname: Campisi
authors.affiliation: David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.
authors.forename: Mary E
authors.initials: ME
authors.lastname: Sehl
authors.affiliation: Department of Physiology and Cardiovascular Research Center, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania.
authors.forename: Rosario
authors.initials: R
authors.lastname: Scalia
authors.affiliation: Department of Physiology and Cardiovascular Research Center, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania.
authors.forename: Satoru
authors.initials: S
authors.lastname: Eguchi
authors.affiliation: Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, South Texas Veterans Health Care System, San Antonio, Texas.
authors.forename: Balakuntalam S
authors.initials: BS
authors.lastname: Kasinath
authors.affiliation: Division of Geriatric and Palliative Medicine, University of Michigan, Ann Arbor, Michigan.
authors.forename: Jeffrey B
authors.initials: JB
authors.lastname: Halter
authors.affiliation: Duke University School of Medicine, Durham, North Carolina.
authors.forename: Harvey Jay
authors.initials: HJ
authors.lastname: Cohen
authors.affiliation: University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham, Alabama.
authors.forename: Wendy
authors.initials: W
authors.lastname: Demark-Wahnefried
authors.affiliation: Memorial Sloan Kettering Cancer Center, New York, New York.
authors.forename: Tim A
authors.initials: TA
authors.lastname: Ahles
authors.affiliation: Institute for Aging Research, Albert Einstein College of Medicine, New York, New York.
authors.forename: Nir
authors.initials: N
authors.lastname: Barzilai
authors.affiliation: City of Hope National Medical Center, Duarte, California.
authors.forename: Arti
authors.initials: A
authors.lastname: Hurria
authors.affiliation: University of California, San Francisco, School of Medicine, San Francisco, California.
authors.forename: Peter W
authors.initials: PW
authors.lastname: Hunt
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D000375:Aging / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D002908:Chronic Disease; D003920:Diabetes Mellitus / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology
keywords: HIV; age-related; aging; cancer; chronic; diabetes; disease; pathology; prevention