title: Increased Invasive Pneumococcal Disease, North East England, UK.
abstract: Since April 2014, invasive pneumococcal disease incidence has increased substantially across North East England, United Kingdom, reversing the decline that followed the 2006 introduction of pneumococcal conjugate vaccines. Significant increases occurred in 23-valent polysaccharide vaccine serotypes and nonvaccine serotypes. Trends in other regions and long-term effects of multivalent vaccines require further investigation.
authors.forename: Catherine
authors.initials: C
authors.lastname: Houseman
authors.forename: Gareth J
authors.initials: GJ
authors.lastname: Hughes
authors.forename: Kaye E
authors.initials: KE
authors.lastname: Chapman
authors.forename: Deborah
authors.initials: D
authors.lastname: Wilson
authors.forename: Russell
authors.initials: R
authors.lastname: Gorton
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D062665:Epidemiological Monitoring; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D008875:Middle Aged; D011008:Pneumococcal Infections / Q000453:epidemiology* / Q000276:immunology / Q000517:prevention & control / Q000821:virology; D022242:Pneumococcal Vaccines / Q000008:administration & dosage*; D065288:Serogroup; D013296:Streptococcus pneumoniae / Q000145:classification* / Q000235:genetics; D006113:United Kingdom / Q000453:epidemiology; D014611:Vaccination / Q000706:statistics & numerical data*
chemical_list: C414006:23-valent pneumococcal capsular polysaccharide vaccine; D022242:Pneumococcal Vaccines
keywords: England; PCV13 vaccine; Streptococcus pneumoniae; United Kingdom; bacteria; incidence; invasive pneumococcal disease; pneumococcal infections; pneumococcal polysaccharide vaccine; vaccines