title: Drug-Loaded Mesoporous Tantalum Oxide Nanoparticles for Enhanced Synergetic Chemoradiotherapy with Reduced Systemic Toxicity.
abstract: Combining chemotherapy and radiotherapy (chemoradiotherapy) has been widely applied in many clinical practices, showing promises in enhancing therapeutic outcomes. Nontoxic nanocarriers that not only are able to deliver chemotherapeutics into tumors, but could also act as radiosensitizers to enhance radiotherapy would thus be of great interest in the development of chemoradiotherapies. To achieve this aim, herein mesoporous tantalum oxide (mTa2O5) nanoparticles with polyethylene glycol (PEG) modification are fabricated. Those mTa2O5-PEG nanoparticles could serve as a drug delivery vehicle to allow efficient loading of chemotherapeutics such as doxorubicin (DOX), whose release appears to be pH responsive. Meanwhile, owing to the interaction of Ta with X-ray, mTa2O5-PEG nanoparticles could offer an intrinsic radiosensitization effect to increase X-ray-induced DNA damages during radiotherapy. As a result, DOX-loaded mTa2O5-PEG (mTa2O5-PEG/DOX) nanoparticles can offer a strong synergistic therapeutic effect during the combined chemoradiotherapy. Furthermore, in chemoradiotherapy, such mTa2O5-PEG/DOX shows remarkably reduced side effects compared to free DOX, which at the same dose appears to be lethal to animals. This work thus presents a new type of mesoporous nanocarrier particularly useful for the delivery of safe and effective chemoradiotherapy.
authors.affiliation: Institute of Functional Nano and Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, the Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University, Suzhou, Jiangsu, 215123, China.
authors.forename: Yuyan
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Institute of Functional Nano and Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, the Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University, Suzhou, Jiangsu, 215123, China.
authors.forename: Guosheng
authors.initials: G
authors.lastname: Song
authors.affiliation: Institute of Functional Nano and Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, the Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University, Suzhou, Jiangsu, 215123, China.
authors.forename: Ziliang
authors.initials: Z
authors.lastname: Dong
authors.affiliation: School of Radiation Medicine and Protection and School for Radiological and Interdisciplinary Sciences (RAD-X), Medical College of Soochow University, Suzhou, Jiangsu, 215123, China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Yi
authors.affiliation: Institute of Functional Nano and Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, the Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University, Suzhou, Jiangsu, 215123, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Chao
authors.affiliation: Institute of Functional Nano and Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, the Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University, Suzhou, Jiangsu, 215123, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Liang
authors.affiliation: School of Radiation Medicine and Protection and School for Radiological and Interdisciplinary Sciences (RAD-X), Medical College of Soochow University, Suzhou, Jiangsu, 215123, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Yang
authors.affiliation: Institute of Functional Nano and Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, the Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University, Suzhou, Jiangsu, 215123, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Cheng
authors.affiliation: Institute of Functional Nano and Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, the Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University, Suzhou, Jiangsu, 215123, China.
authors.forename: Zhuang
authors.initials: Z
authors.lastname: Liu
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D059248:Chemoradiotherapy; D004195:Disease Models, Animal; D004317:Doxorubicin / Q000494:pharmacology*; D065546:Drug Liberation; D051379:Mice; D053758:Nanoparticles / Q000633:toxicity* / Q000648:ultrastructure; D010087:Oxides / Q000633:toxicity*; D016062:Porosity; D013635:Tantalum / Q000633:toxicity*; D018675:Toxicity Tests
chemical_list: D010087:Oxides; D013635:Tantalum; D004317:Doxorubicin; C078151:tantalum oxide
keywords: chemoradiotherapy; drug delivery; mesoporous tantalum oxide; systemic toxicity