title: Fabrication of novel magnesium-matrix composites and their mechanical properties prior to and during in vitro degradation.
abstract: In our previous study, we developed Mg-matrix composites with bredigite as the reinforcing phase and achieved improved degradation resistance in comparison with Mg. However, the effects of materials processing method and process parameters on the mechanical behavior of the composites before and during degradation were still unknown. This research was aimed at determining the mechanical properties of Mg-bredigite composites prior to and during degradation. It was found that by optimizing the process parameters of Pressure Assisted Sintering (PAS), low-porosity Mg-bredigite composites with strong interfaces between homogeneously distributed bredigite particles and the Mg matrix could be fabricated. By reinforcing Mg with 20vol% bredigite particles, the ultimate compressive strength and ductility of Mg increased by 67% and 111%, respectively. The in vitro degradation rate of the Mg-20% bredigite composite in a cell culture medium was 24 times lower than that of monolithic Mg. As a result of retarded degradation, the mechanical properties of the composite after 12 days of immersion in the cell culture medium were comparable to those of cortical bone. The encouraging results of this research warrant further investigations on the in vivo degradation behavior and mechanical properties of the composites.
authors.affiliation: Department of Biomechanical Engineering, Delft University of Technology, 2628 CD Delft, The Netherlands.
authors.forename: Sina Naddaf
authors.initials: SN
authors.lastname: Dezfuli
authors.affiliation: Department of Biomechanical Engineering, Delft University of Technology, 2628 CD Delft, The Netherlands.
authors.forename: Sander
authors.initials: S
authors.lastname: Leeflang
authors.affiliation: Biomaterials and Tissue Engineering Research Center, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China.
authors.forename: Zhiguang
authors.initials: Z
authors.lastname: Huan
authors.affiliation: Biomaterials and Tissue Engineering Research Center, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Chang
authors.affiliation: Department of Biomechanical Engineering, Delft University of Technology, 2628 CD Delft, The Netherlands.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhou
mesh_terms: D020341:Absorbable Implants; D001672:Biocompatible Materials / Q000032:analysis*; D002516:Ceramics / Q000032:analysis*; D019245:Compressive Strength; D008274:Magnesium / Q000032:analysis*; D008422:Materials Testing; D016062:Porosity; D013718:Tensile Strength
chemical_list: D001672:Biocompatible Materials; D008274:Magnesium
keywords: Bredigite; Degradation; Magnesium; Magnesium-matrix composites; Mechanical properties