title: A non-chiral lithium aluminate reagent for the determination of enantiomeric excess of chiral alcohols.
abstract: Here we illustrate a new method for the rapid determination of ee's of chiral alcohols using the thermally-stable, non-chiral lithium aluminate reagent [EtAl(6-Me-2-py)3Li] (1). In situ reaction of the alcohols with 1 produces robust dimers in solution, present as diastereomeric pairs (SS/RR and RS) with distinct resonances in their1H and7Li NMR spectra. The ee can be calculated simply from integration of the1H and/or7Li NMR spectra.
authors.affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK. rg489@cam.ac.uk.
authors.forename: Raúl
authors.initials: R
authors.lastname: García-Rodríguez
authors.affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK. rg489@cam.ac.uk.
authors.forename: Schirin
authors.identifier: http://orcid.org/0000-0003-2624-7872
authors.initials: S
authors.lastname: Hanf
authors.affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK. rg489@cam.ac.uk.
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Bond
authors.affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK. rg489@cam.ac.uk.
authors.forename: Dominic S
authors.initials: DS
authors.lastname: Wright