title: Exploring the Reactivity of 2-Trichloromethylbenzoxazoles for Access to Substituted Benzoxazoles.
abstract: The reactivity of 2-trichloromethylbenzoxazoles toward various nucleophiles, under metal-free or iron-catalyzed conditions, for the synthesis of substituted benzoxazoles is described. These methods allow for selective substitution at either the 2- or 2'-position of the benzoxazoles using the same starting materials/reagents. This approach allows for the controlled synthesis of a variety of key derivatives from a single 2-trichloromethylbenzoxazole starting material.
authors.affiliation: School of Chemistry, University of Nottingham , Nottingham NG7 2RD, United Kingdom.
authors.forename: Roy P
authors.initials: RP
authors.lastname: Lester
authors.affiliation: Department of Chemical Sciences, University of Huddersfield , Queensgate, Huddersfield, HD1 3DH, United Kingdom.
authors.forename: Travis
authors.initials: T
authors.lastname: Bham
authors.affiliation: Department of Chemical Sciences, University of Huddersfield , Queensgate, Huddersfield, HD1 3DH, United Kingdom.
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Bousfield
authors.affiliation: School of Chemistry, University of Nottingham , Nottingham NG7 2RD, United Kingdom.
authors.forename: William
authors.identifier: 0000-0001-7103-6981
authors.initials: W
authors.lastname: Lewis
authors.affiliation: School of Chemistry, University of Nottingham , Nottingham NG7 2RD, United Kingdom.|Department of Chemical Sciences, University of Huddersfield , Queensgate, Huddersfield, HD1 3DH, United Kingdom.
authors.forename: Jason E
authors.identifier: 0000-0001-7394-2101
authors.initials: JE
authors.lastname: Camp