title: MyD 88 Polymorphisms in Children Diagnosed with Sepsis.
abstract: BACKGROUND
  Myeloid differentiation primary response gene 88 (MyD 88) is an intracellular adapter protein that mediates the early immune response to pathogens. Toll-like receptors (except TLR-3) induce the immune response through a MyD 88-dependent signal pathway.
  
  
  OBJECTIVE
  We aimed to investigate the MyD 88 polymorphisms that play important roles in the immune response in septic children and to evaluate whether or not they were risk factors in the development of sepsis.
  
  
  METHODS
  Case-control study.
  
  
  METHODS
  Sixty-five patients diagnosed with sepsis in the Pediatric Intensive Care Unit during the period from April 2010 to January 2012 were included as the study group. Sixty-five children without sepsis were included as controls. After DNA was obtained from blood samples in the study and control groups, MyD 88 polymorphisms were analyzed. According to the genotype and allele frequencies, the distributions of MyD 88 polymorphisms [Single nucleotide polymorphism (SNP) - 938 C/A (rs4988453), MyD 88 SNP 1944 C/G (rs4988457)] were analyzed in both the study and control groups.
  
  
  RESULTS
  The C/C genotype of MyD 88 SNP -938 was significantly more common than the C/A genotype in the patient group (p=0.002). No statistically significant difference in the frequency of the MyD 88 SNP 1944 genotype was found between the study and control groups (p=0.272).
  
  
  CONCLUSIONS
  Gene polymorphism studies could elucidate our understanding of sepsis in terms of prevalence and the management of treatment. It was shown in this study that children with the MyD 88 SNP -938 C/C genotype had a greater tendency toward sepsis. However, additional studies should be performed.
authors.affiliation: Deparment of Pediatrics, Çukurova University School of Medicine, Adana, Turkey.
authors.forename: Sinem Sarı
authors.initials: SS
authors.lastname: Gökay
authors.affiliation: Deparment of Pediatric Intensive Care, Çukurova University School of Medicine, Adana, Turkey.
authors.forename: Rıza Dinçer
authors.initials: RD
authors.lastname: Yıldızdaş
authors.affiliation: Deparment of Pediatrics, Çukurova University School of Medicine, Adana, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Yılmaz
authors.affiliation: Department of Biochemistry, Çukurova University School of Medicine, Adana, Turkey.
authors.forename: Kıymet
authors.initials: K
authors.lastname: Aksoy
authors.affiliation: Department of Biochemistry, Çukurova University School of Medicine, Adana, Turkey.
authors.forename: Ali Erdinç
authors.initials: AE
authors.lastname: Yalın
authors.affiliation: Department of Biostatistics, Çukurova University School of Medicine, Adana, Turkey.
authors.forename: Yaşar
authors.initials: Y
authors.lastname: Sertdemir
authors.affiliation: Department of Pediatric Immunology Laboratory, Çukurova University School of Medicine, Adana, Turkey.
authors.forename: Gülsüm
authors.initials: G
authors.lastname: Uçar
authors.affiliation: Deparment of Pediatric Intensive Care, Çukurova University School of Medicine, Adana, Turkey.
authors.forename: Özden Özgür
authors.initials: ÖÖ
authors.lastname: Horoz
authors.affiliation: Deparment of Pediatrics, Çukurova University School of Medicine, Adana, Turkey.
authors.forename: Fatma Derya
authors.initials: FD
authors.lastname: Özduran
authors.affiliation: Deparment of Pediatrics, Çukurova University School of Medicine, Adana, Turkey.
authors.forename: Hayri Levent
authors.initials: HL
authors.lastname: Yılmaz
keywords: Children; MyD 88 gene polymorphism; sepsis