title: Epilepsy and vitamin D: a comprehensive review of current knowledge.
abstract: Vitamin D has been considered as neurosteroid, and its pivotal role in neuroprotection, brain development, and immunomodulation has been noticed in studies; however, our knowledge regarding its role in neurological disorders is still developing. The potential role of vitamin D in the pathophysiology and treatment of epilepsy, as one the most prevalent neurological disorders, has received less attention in recent years. In this article, we review the possible relationship between vitamin D and epilepsy from different aspects, including the action mechanism of vitamin D in the central nervous system and ecological and epidemiological findings. We also present the outcome of studies that evaluated the level of vitamin D and the impact of administrating vitamin D in epileptic patients or animal subjects. We also review the current evidence on interactions between vitamin D and antiepileptic drugs.
authors.forename: Seyed Amir
authors.initials: SA
authors.lastname: Miratashi Yazdi
authors.forename: Mehdi
authors.initials: M
authors.lastname: Abbasi
authors.forename: Seyed Masoud
authors.initials: SM
authors.lastname: Miratashi Yazdi
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D004195:Disease Models, Animal; D004827:Epilepsy / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D018377:Neurotransmitter Agents / Q000627:therapeutic use*; D014807:Vitamin D / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D000927:Anticonvulsants; D018377:Neurotransmitter Agents; D014807:Vitamin D