title: Copper(II)-Catalyzed Benzylic C(sp3)-H Aerobic Oxidation of (Hetero)Aryl Acetimidates: Synthesis of Aryl-α-ketoesters.
abstract: A straightforward method is developed in this paper for the synthesis of α-ketoesters through copper-catalyzed aerobic oxidation of (hetero)aryl acetimidates using molecular oxygen as a sustainable oxidant. The reaction represents the first example of the direct synthesis of aryl-α-ketoesters from arylacetimidates through the aerobic oxidation of a benzylic C(sp3)-H (C═O) bond in moderate to good yield. This transformation occurs under mild reaction conditions with a wide range of substrates and utilizes a readily available oxidant and catalyst. The synthetic utility of this transformation is demonstrated through scaled-up synthesis. A plausible reaction mechanism is also proposed.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Patna , Bihta 801103, Bihar, India.
authors.forename: Yogesh
authors.initials: Y
authors.lastname: Kumar
authors.affiliation: Department of Chemistry, Indian Institute of Technology Patna , Bihta 801103, Bihar, India.
authors.forename: Yogesh
authors.initials: Y
authors.lastname: Jaiswal
authors.affiliation: Department of Chemistry, Indian Institute of Technology Patna , Bihta 801103, Bihar, India.
authors.forename: Amit
authors.identifier: 0000-0002-1683-7740
authors.initials: A
authors.lastname: Kumar