title: Evaluation of serum interleukin- 35 level in children with persistent asthma.
abstract: BACKGROUND
  IL-35 is a novel cytokine suppressing the immune response through the expansion of regulatory T cells and suppression of Th17 cell development. Few studies have been done on the effect of this cytokine in a different disease. Asthma is a complex disease that many inflammatory cells and cytokines play a role in.
  
  
  OBJECTIVE
  We decide to determine the difference between serum level of IL-35 in childhood asthma & healthy children.
  
  
  METHODS
  We obtained serum samples from 44 asthmatic children between 2 and 15 years as a case group and from healthy children as a control group. IL-35 serum concentration was determined by ELISA method in both groups.
  
  
  RESULTS
  Mean serum level is 30.9 pg/ml in the case group and 30.2 pg/ml in the control group. There is no significant difference between serum level of IL-35 in asthmatic & healthy children.
  
  
  CONCLUSIONS
  Our data reveal no relation between childhood asthma and serum level of IL35. So, further study will be needed to clarify effects of this cytokine in human allergic diseases.
authors.affiliation: Allergy Research Center, Mashhad University of Medical Sciences, Mashhad , Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Khoshkhui
authors.affiliation: Shiraz Allergy Research Center, Shiraz University of Medical Sciences.Shiraz ,Iran.
authors.forename: Soheyla
authors.initials: S
authors.lastname: Alyasin
authors.affiliation: AutoImmune disease Research Center, Shiraz University of Medical Sciences.
authors.forename: Eskandar Kamali
authors.initials: EK
authors.lastname: Sarvestani
authors.affiliation: Department of Allergy and Clinical Immunology, Shiraz University of Medical sciences ,Shiraz, Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Amin
authors.affiliation: Allergy Research Center, Mashhad University of Medical Sciences, Shiraz, Iran.
authors.forename: Nazila
authors.initials: N
authors.lastname: Ariaee
mesh_terms: D000293:Adolescent; D001249:Asthma / Q000097:blood* / Q000145:classification; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005541:Forced Expiratory Volume; D064368:Healthy Volunteers; D006801:Humans; D007378:Interleukins / Q000097:blood*; D008297:Male
chemical_list: D007378:Interleukins; C532417:interleukin-35, human