title: The influence of teriparatide in induced tooth movement: A systematic review.
abstract: BACKGROUND
  Teriparatide is a synthetic drug similar than PTH (parathyroid hormone), which is currently used as long-term treatment option for patients with bone chronic diseases, as osteoporosis; and this drug can interfere in a positive way in orthodontic movement. Objectives: The medical literature was assessed in the present systematic review in order to determine the level of scientific evidence supporting the influence of teriparatide in induced tooth movement.
  
  
  METHODS
  The PRISMA Checklist was followed in this systematic review. Four electronic databases (PubMed; Scopus; ScienceDirect; OpenGrey) were searched without implementing restrictions of year, status, and language of publications. The inclusion criteria consisted of selecting only experimental studies comparing the influence of teriparatide in tooth movement of male Wistar rats. The exclusion criteria consisted of experiments with female rats or other experimental animals, and animals with pathologic conditions. The eligible studies were evaluated based on methodological quality. Two trained examiners performed all the research steps.
  
  
  RESULTS
  The initial sample comprised 700 studies, which was reduced to 664 after the exclusion of duplicates (n=36). Three articles were selected for the final qualitative analysis. The local administration of parathyroid hormone (PTH) 1-34 or PTH 1-84 revealed major effectiveness when compared with control groups and systematic administration. Additionally, the dilution of PTH 1-34 within methyl cellulose (MC) gel increased the time range for drug release, enabling to reduce the drug concentration without decreasing the effectiveness of tooth movement.
  
  
  CONCLUSIONS
  Teriparatide demonstrated potential acceleration of tooth movement in Wistar rats depending on the drug concentration; drug administration; and time for drug release.Key words:Teriparatide, tooth movement, parathyroid hormone, orthodontics.
authors.affiliation: Undergraduate student, Department of Dentistry, Federal University of Sergipe, Lagarto, SE, Brazil.
authors.forename: Bianca-Núbia
authors.initials: BN
authors.lastname: Souza-Silva
authors.affiliation: Undergraduate student, Department of Dentistry, Federal University of Sergipe, Lagarto, SE, Brazil.
authors.forename: José-Lucas-Sani-de Alcântara
authors.initials: JA
authors.lastname: Rodrigues
authors.affiliation: Undergraduate student, Department of Dentistry, Federal University of Sergipe, Lagarto, SE, Brazil.
authors.forename: Jefferson-Chaves
authors.initials: JC
authors.lastname: Moreira
authors.affiliation: DDS, MSc, Postgraduate Program in Dentistry, Federal University of Sergipe, Aracaju, SE, Brazil.
authors.forename: Felipe-de Souza
authors.initials: FS
authors.lastname: Matos
authors.affiliation: DDS, MSc, PhD, Professor, Department of Speech Therapy, Federal University of Sergipe, Lagarto, SE, Brazil.
authors.forename: Carla-Patrícia-Hernandez-Alves-Ribeiro
authors.initials: CP
authors.lastname: Cesar
authors.affiliation: DDS, MSc, PhD, Professor, Department of Dentistry, Federal University of Sergipe, Lagarto, SE, Brazil.
authors.forename: Carlos-Eduardo-Palanch
authors.initials: CE
authors.lastname: Repeke
authors.affiliation: DDS, MSc, PhD, Professor, Department of Dentistry, Federal University of Sergipe, Lagarto, SE, Brazil.
authors.forename: Luiz-Renato
authors.initials: LR
authors.lastname: Paranhos