title: Effect of an education program on knowledge, self-care behavior and handwashing competence on prevention of febrile neutropenia among breast cancer patients receiving Doxorubicin and Cyclophosphamide in Chemotherapy Day Centre.
abstract: OBJECTIVE
  To evaluate the efficacy of an education program on the prevention of febrile neutropenia (FN) among breast cancer patients receiving AC regimen.
  
  
  METHODS
  Randomized controlled trial with the repeated-measures design was conducted in a Chemotherapy Day Centre of an acute hospital in Hong Kong. Twenty-five subjects in the intervention group received an individual education session followed by three follow-up sessions and routine care. Twenty-four subjects in the control group received routine care. Primary outcomes included the incidence of admission due to FN, the self-care behavior adherence, the knowledge level on prevention of FN and the self-efficacy in self-management, handwashing competence were assessed by self-designed questionnaires, Chinese version of patient activation measure, and handwashing competence checklist.
  
  
  RESULTS
  No statistically significant difference between the intervention group and the control group on the incidence of admission due to FN, the self-efficacy in self-management, and the knowledge on prevention of FN. The self-care behavior adherence was significant at cycle 4 of AC regimen in favor of the intervention group (P= 0.036). Handwashing competence improved more significantly among subjects in the intervention group than the control group (P= 0.009).
  
  
  CONCLUSIONS
  The education program on the prevention of FN had significantly favorable effects on self-care behavior adherence and handwashing competence across time. However, the intervention did not lead to statistically significant improvement on the incidence of admission due to FN, the self-efficacy in self-management and the knowledge level on prevention of FN.
authors.affiliation: Department of Clinical Oncology, Prince of Wales Hospital, Hong Kong, SAR, China.
authors.forename: Wai Chi
authors.initials: WC
authors.lastname: Mak
authors.affiliation: School of Nursing, The Hong Kong Polytechnic University, Hong Kong, SAR, China.
authors.forename: Shirley Siu
authors.initials: SS
authors.lastname: Yin Ching
keywords: Chemotherapy; education; febrile neutropenia; neutropenia