title: Sulfonimidamides in Medicinal and Agricultural Chemistry.
abstract: The synthesis and evaluation of structural analogues and isosteres are of central importance in medicinal and agricultural chemistry. The sulfonamide functional group represents one of the most important amide isosteres in contemporary drug design, and about 500 such compounds have overcome both the pharmacological and regulatory hurdles that precede studies in humans. The mono aza analogues of sulfonamides, that is, sulfonimidamides, are rapidly gaining popularity as a novel functional group among synthetic chemists involved in the design of biologically active compounds for both pharmaceutical and agrochemical applications. Herein, we review these recent developments to showcase the promise of this functional group.
authors.affiliation: Catalysis and Peptide Research Unit, University of KwaZulu Natal, Durban, 4001, South Africa.
authors.forename: Praveen K
authors.initials: PK
authors.lastname: Chinthakindi
authors.affiliation: Catalysis and Peptide Research Unit, University of KwaZulu Natal, Durban, 4001, South Africa.
authors.forename: Tricia
authors.identifier: 0000-0002-7134-6258
authors.initials: T
authors.lastname: Naicker
authors.affiliation: Catalysis and Peptide Research Unit, University of KwaZulu Natal, Durban, 4001, South Africa.
authors.forename: Niranjan
authors.initials: N
authors.lastname: Thota
authors.affiliation: Catalysis and Peptide Research Unit, University of KwaZulu Natal, Durban, 4001, South Africa.
authors.forename: Thavendran
authors.identifier: 0000-0003-2511-2503
authors.initials: T
authors.lastname: Govender
authors.affiliation: Catalysis and Peptide Research Unit, University of KwaZulu Natal, Durban, 4001, South Africa.
authors.forename: Hendrik G
authors.identifier: 0000-0003-0606-2053
authors.initials: HG
authors.lastname: Kruger
authors.affiliation: Catalysis and Peptide Research Unit, University of KwaZulu Natal, Durban, 4001, South Africa.|Science for Life Laboratory, Drug Discovery and Development Platform and Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17177, Stockholm, Sweden.
authors.forename: Per I
authors.identifier: 0000-0002-9453-6812
authors.initials: PI
authors.lastname: Arvidsson
mesh_terms: D002622:Chemistry, Agricultural; D002626:Chemistry, Pharmaceutical; D015195:Drug Design; D006801:Humans; D015394:Molecular Structure; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D013449:Sulfonamides
keywords: agricultural chemistry; bioisosteres; drug design; medicinal chemistry; sulfonimidamides