title: Actin-based motility and cell-to-cell spread of bacterial pathogens.
abstract: Subversion of the host actin cytoskeleton is a critical virulence mechanism used by a variety of intracellular bacterial pathogens during their infectious life cycles. These pathogens manipulate host actin to promote actin-based motility and coordinate motility with cell-to-cell spread. Growing evidence suggests that the tactics employed by pathogens are surprisingly diverse. Here, we review recent advances suggesting that bacterial surface proteins exhibit divergent biochemical mechanisms of actin polymerization and recruit distinct host protein networks to drive motility, and that bacteria deploy secreted effector proteins that alter host cell mechanotransduction pathways to enable spread. Further investigation into the divergent strategies used by bacterial pathogens to mobilize actin will reveal new insights into pathogenesis and cytoskeleton regulation.
authors.affiliation: Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA. Electronic address: rlamason@berkeley.edu.
authors.forename: Rebecca L
authors.initials: RL
authors.lastname: Lamason
authors.affiliation: Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA. Electronic address: welch@berkeley.edu.
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Welch
mesh_terms: D008841:Actin Cytoskeleton / Q000502:physiology*; D000199:Actins / Q000502:physiology*; D000818:Animals; D001419:Bacteria / Q000378:metabolism / Q000472:pathogenicity*; D001424:Bacterial Infections / Q000382:microbiology*; D018407:Bacterial Physiological Phenomena; D001426:Bacterial Proteins / Q000378:metabolism*; D003593:Cytoplasm / Q000382:microbiology; D054884:Host-Pathogen Interactions; D008124:Locomotion; D051379:Mice; D008870:Microtubules; D014774:Virulence
chemical_list: D000199:Actins; D001426:Bacterial Proteins