title: Alterations of Intestinal Labile Zinc and Cytokine Production Following Subarachnoid Hemorrhage in Rats.
abstract: Intestinal mucosal injury can be frequently observed in the patients suffering from subarachnoid hemorrhage (SAH). Labile zinc and inflammatory mediators participate in many pathophysiological processes. This study aimed to investigate the increase of intestinal labile zinc, wet/dry weight ratio, and the expression of inflammatory mediators after SAH. As a result, SAH caused a gradual increase of intestinal labile zinc as demonstrated by fluorescence staining with Zinpyr-4 (ZP4). The levels of TNF-α and IL-6 and the intestinal wet/dry weight ratios were higher in the SAH groups compared to the control group following SAH (p<0.05). The results suggest that SAH induces increases of labile zinc and inflammatory mediators in gut, which may participate in the pathogenesis of acute intestinal mucosal injury.
authors.affiliation: Department of Neurosurgery, Wuxi Second Hospital Affiliated Nanjing Medical University, Nanjing, Jiangsu Province, China.
authors.forename: Xudong
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of Neurosurgery, Wuxi Second Hospital Affiliated Nanjing Medical University, Nanjing, Jiangsu Province, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Neurosurgery, Wuxi Second Hospital Affiliated Nanjing Medical University, Nanjing, Jiangsu Province, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhu
authors.affiliation: Department of Neurosurgery, Wuxi Second Hospital Affiliated Nanjing Medical University, Nanjing, Jiangsu Province, China luxiaojie1966@aliyun.com.
authors.forename: Xiaojie
authors.initials: X
authors.lastname: Lu
mesh_terms: D000818:Animals; D005452:Fluoresceins / Q000378:metabolism; D005453:Fluorescence; D007249:Inflammation / Q000473:pathology; D015850:Interleukin-6 / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism* / Q000473:pathology; D008297:Male; D009929:Organ Size; D051381:Rats; D017207:Rats, Sprague-Dawley; D013345:Subarachnoid Hemorrhage / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*; D015032:Zinc / Q000378:metabolism*
chemical_list: D005452:Fluoresceins; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; C501988:Zinpyr-4; D015032:Zinc