title: Evaluation of folic acid tagged aminated starch/ZnO coated iron oxide nanoparticles as targeted curcumin delivery system.
abstract: The role of 'superparamagnetic iron oxide nanoparticles' has gained considerable interest in various biomedical applications. However extensive researches are still going on to modify the nanoparticle size, surface properties etc. in order to get full benefit of the material. In this study, iron oxide nanoparticles have been modified with folic acid tagged aminated starch/ZnO coating to formulate a targeted drug delivery system. The nanoparticles were characterized by Fourier Transform Infra-red Spectroscopy, X-ray Diffraction, Scanning Electron Microscopy and Transmission Electron Microscopy. Both the swelling and in vitro drug release was performed in both acidic and alkaline pH. The cytotoxicity of the drug loaded nanoparticles was analysed by MTT assay in human lymphocytes, HepG2 and MCF7 cell lines. The cell uptake efficiencies and Reactive Oxygen Species generation with the drug loaded nanoparticles was estimated in HepG2 cell lines. The uptake capacity of fluorescein isothiocyanate tagged nanoparticles was assessed by fluorescence microscope.
authors.affiliation: Department of Chemical Sciences, Tezpur University, Assam 784028, India.
authors.forename: Chinmayee
authors.initials: C
authors.lastname: Saikia
authors.affiliation: Department of Molecular Biology and Biotechnology, Tezpur University, Assam 784028, India.
authors.forename: Monoj K
authors.initials: MK
authors.lastname: Das
authors.affiliation: Department of Molecular Biology and Biotechnology, Tezpur University, Assam 784028, India.
authors.forename: Anand
authors.initials: A
authors.lastname: Ramteke
authors.affiliation: Department of Chemical Sciences, Tezpur University, Assam 784028, India. Electronic address: tkm@tezu.ernet.in.
authors.forename: Tarun K
authors.initials: TK
authors.lastname: Maji
mesh_terms: D003474:Curcumin / Q000008:administration & dosage*; D016503:Drug Delivery Systems; D005492:Folic Acid; D056945:Hep G2 Cells; D006801:Humans; D058185:Magnetite Nanoparticles; D046529:Microscopy, Electron, Transmission; D017550:Spectroscopy, Fourier Transform Infrared; D013213:Starch; D015034:Zinc Oxide
chemical_list: D058185:Magnetite Nanoparticles; D013213:Starch; D005492:Folic Acid; D003474:Curcumin; D015034:Zinc Oxide
keywords: Aminated starch; Drug delivery; Iron oxide; Zinc oxide