title: Copper-Catalyzed C-H Oxidative Radical Functionalization and Annulation of Aniline-Linked 1,7-Enynes: Evidence for a 1,5-Hydride Shift Mechanism.
abstract: A new copper-catalyzed tandem C-H oxidative radical functionalization and annulation of aniline-linked 1,7-enynes with alkyl nitriles or acetone is described. This reaction allows the selective construction of 1H-cyclopenta[c]quinolines and benzo[j]phenanthridin-6(5H)-ones which rely on the substitution effect at the 2-position of the acrylamide moiety. The mechanism involving a 1,5-hydride shift process is proposed according to the control deuterium-labeled experiment.
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University , Changsha 410082, China.|Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle, Nanchang Hangkong University , Nanchang 330063, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Hu
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University , Changsha 410082, China.|Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle, Nanchang Hangkong University , Nanchang 330063, China.
authors.forename: Hua-Xu
authors.initials: HX
authors.lastname: Zou
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University , Changsha 410082, China.|Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle, Nanchang Hangkong University , Nanchang 330063, China.
authors.forename: Ren-Jie
authors.initials: RJ
authors.lastname: Song
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University , Changsha 410082, China.|Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle, Nanchang Hangkong University , Nanchang 330063, China.
authors.forename: Jian-Nan
authors.initials: JN
authors.lastname: Xiang
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University , Changsha 410082, China.|Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle, Nanchang Hangkong University , Nanchang 330063, China.
authors.forename: Jin-Heng
authors.identifier: 0000-0001-7215-7152
authors.initials: JH
authors.lastname: Li