title: A return to the pore - dissecting Bacillus thuringiensis toxin mode of action via voltage clamp experiments.
abstract: Pore-forming toxins from Bacillus thuringiensis are increasingly used in crop protection, but evolution of resistance in crop pests threatens their continued deployment. A study by Tanaka et al. shows how voltage clamp experiments that quantify pore formation can be used to dissect toxin mode of action, thereby revealing unexpected complexities that could be exploited to counter resistance.
authors.affiliation: Department of Entomology, Max Planck Institute for Chemical Ecology, Jena, Germany.
authors.forename: David G
authors.initials: DG
authors.lastname: Heckel
mesh_terms: D001413:Bacillus thuringiensis; D001426:Bacterial Proteins; D004731:Endotoxins; D006460:Hemolysin Proteins
chemical_list: D001426:Bacterial Proteins; D004731:Endotoxins; D006460:Hemolysin Proteins