title: Pathophysiology of Non Alcoholic Fatty Liver Disease.
abstract: The physiopathology of fatty liver and metabolic syndrome are influenced by diet, life style and inflammation, which have a major impact on the severity of the clinicopathologic outcome of non-alcoholic fatty liver disease. A short comprehensive review is provided on current knowledge of the pathophysiological interplay among major circulating effectors/mediators of fatty liver, such as circulating lipids, mediators released by adipose, muscle and liver tissues and pancreatic and gut hormones in relation to diet, exercise and inflammation.
authors.affiliation: Gastroenterology, Di.Bi.M.I.S Policlinic Paolo Giaccone Hospital, University of Palermo, PC 90127, Palermo, Italy. petsa@inwind.it.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Petta
authors.affiliation: Cardiometabolic Risk Unit-Institute of Clinical Physiology, CNR, PC 56124, Pisa, Italy. amalia@ifc.cnr.it.
authors.forename: Amalia
authors.initials: A
authors.lastname: Gastaldelli
authors.affiliation: Department of Clinical and Experimental Medicine, University of Pisa, PC 56122, Pisa, Italy. elenirebelos@gmail.com.
authors.forename: Eleni
authors.initials: E
authors.lastname: Rebelos
authors.affiliation: Gastroenterology and Hepatology, Department of Medical Sciences, Città della, Salute e della Scienza di Torino Hospital, University of Turin, PC 10122, Turin, Italy. ebugianesi@yahoo.it.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Bugianesi
authors.affiliation: Department of Nephrology, Urology and Renal Transplant-Fondazione IRCCS Ca', Granda, PC 20122 Milano, Italy. pmessa@policlinico.mi.it.
authors.forename: Piergiorgio
authors.initials: P
authors.lastname: Messa
authors.affiliation: Institute of Internal Medicine, Gastroenterology and Liver Diseases Unit, Fondazione Policlinico Gemelli, Catholic University of Rome, PC 00168, Rome, Italy. luca.miele@policlinicogemelli.it.
authors.forename: Luca
authors.initials: L
authors.lastname: Miele
authors.affiliation: Department of Gastroenterology 1 and Obesity 2, Polytechnic University of Marche, PC 60121, Ancona, Italy. gsvegliati@gmail.com.
authors.forename: Gianluca
authors.initials: G
authors.lastname: Svegliati-Baroni
authors.affiliation: Metabolic Liver Diseases-Università degli Studi Milano-Fondazione IRCCS Ca', Granda via F Sforza 35, PC 20122 Milano, Italy. luca.valenti@unimi.it.
authors.forename: Luca
authors.initials: L
authors.lastname: Valenti
authors.affiliation: Department of Clinical and Experimental Medicine, University of Pisa, PC 56122, Pisa, Italy. ferruccio.bonino@unipi.it.|Institute for Health, PC 53042, Chianciano Terme, Italy. ferruccio.bonino@unipi.it.
authors.forename: Ferruccio
authors.initials: F
authors.lastname: Bonino
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D005768:Gastrointestinal Hormones / Q000378:metabolism; D006801:Humans; D008055:Lipids / Q000097:blood; D009132:Muscles / Q000378:metabolism; D065626:Non-alcoholic Fatty Liver Disease / Q000097:blood / Q000503:physiopathology*; D010187:Pancreatic Hormones / Q000378:metabolism
chemical_list: D005768:Gastrointestinal Hormones; D008055:Lipids; D010187:Pancreatic Hormones
keywords: adiponectin; cholesterol; fatty liver; free fatty acids; ghrelin; glucagon; glucagon-like peptide 1; insulin; insulin resistance; irisin; leptin; selenoprotein P