title: Hepatoprotection of enzymatic-extractable mycelia zinc polysaccharides by Pleurotus eryngii var. tuoliensis.
abstract: The purpose of this work was designed to investigate the hepatoprotective and antioxidant effects of enzymatic-extractable mycelia zinc polysaccharides (En-MZPS) from Pleurotus eryngii var. tuoliensis on the hyperlipidemic mice induced by high-fat-high-cholesterol emulsion (HFHCM). The results showed that the supplementation of En-MZPS had potential anti-hyperlipidemia effects on reducing hepatic lipid levels by monitoring the serum enzyme activities (ALP, ALT and AST) and serum lipid levels (TC, TG, HDL-C, LDL-C and VLDL-C), enhancing the antioxidant enzymes (SOD, GSH-Px, CAT and T-AOC), and decreasing the lipid peroxidation (MDA and LPO). Furthermore, the in vitro scavenging results indicated that the inhibition effects of En-MZPS on hydroxyl radicals and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals reached 59.98±6.29% and 37.01±2.15%, respectively. These conclusions demonstrated that the En-MZPS might be suitable for functional foods and natural drugs in preventing the HFHCM-induced hyperlipidemia and non-alcoholic fatty liver.
authors.affiliation: Institute of Plant and Environment Protection, Beijing Academy of Agriculture and Forestry Sciences, Beijing Engineering Research Center for Edible Mushroom, Key Laboratory of Urban Agriculture (North), Ministry of Agriculture, Beijing, PR China; College of Life Science, Shandong Agricultural University, Taian, 271018, PR China.
authors.forename: Nuo
authors.initials: N
authors.lastname: Xu
authors.affiliation: College of Life Science, Shandong Agricultural University, Taian, 271018, PR China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Gao
authors.affiliation: College of Life Science, Shandong Agricultural University, Taian, 271018, PR China.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Zhang
authors.affiliation: College of Life Science, Shandong Agricultural University, Taian, 271018, PR China.
authors.forename: Huijuan
authors.initials: H
authors.lastname: Jing
authors.affiliation: College of Life Science, Shandong Agricultural University, Taian, 271018, PR China.
authors.forename: Shangshang
authors.initials: S
authors.lastname: Li
authors.affiliation: College of Life Science, Shandong Agricultural University, Taian, 271018, PR China.
authors.forename: Zhenzhen
authors.initials: Z
authors.lastname: Ren
authors.affiliation: Institute of Plant and Environment Protection, Beijing Academy of Agriculture and Forestry Sciences, Beijing Engineering Research Center for Edible Mushroom, Key Laboratory of Urban Agriculture (North), Ministry of Agriculture, Beijing, PR China. Electronic address: wangshouxian2002@163.com.
authors.forename: Shouxian
authors.initials: S
authors.lastname: Wang
authors.affiliation: College of Life Science, Shandong Agricultural University, Taian, 271018, PR China. Electronic address: jia__le@126.com.
authors.forename: Le
authors.initials: L
authors.lastname: Jia
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology; D008099:Liver / Q000187:drug effects*; D051379:Mice; D025282:Mycelium / Q000737:chemistry*; D020076:Pleurotus / Q000737:chemistry*; D011134:Polysaccharides / Q000302:isolation & purification / Q000494:pharmacology*; D015032:Zinc / Q000737:chemistry
chemical_list: D000975:Antioxidants; D011134:Polysaccharides; D015032:Zinc
keywords: Enzymatic-extractable; Hepatoprotective effects; Mycelia zinc polysaccharides; Pleurotus eryngii var. tuoliensis