title: SINGLE-SHOT TURBO SPIN ECHO PULSE SEQUENCE FINDINGS IN DOGS WITH AND WITHOUT PROGRESSIVE MYELOMALACIA.
abstract: Progressive myelomalacia is an uncommon type of ischemic, hemorrhagic spinal cord infarction. Diagnosis can be difficult, but prompt recognition is important. We hypothesized that cerebrospinal fluid signal attenuation on magnetic resonance (MR) images would be more extensive in dogs that developed progressive myelomalacia vs. control dogs. A retrospective analytic cohort study was designed. Dogs were included if they presented for acute paraplegia and loss of deep pain perception and had undergone MR imaging using both sagittal single-shot turbo spin echo (SSTSE) and standard sagittal T2-weighted fast spin echo (T2W) pulse sequences. Dogs were divided into progressive myelomalacia and control groups for comparisons. All MR examinations were evaluated by three reviewers blinded to patient outcome. Length of cerebrospinal fluid attenuation was recorded as a ratio to the length of the L2 vertebral body in SSTSE and T2W sequences (CSF:L2SSTSEand CSF:L2T2, respectively). Length of intramedullary spinal cord hyperintensity was recorded as a ratio to the length of the L2 vertebral body in T2W sequences. A total of 21 dogs were included (five in the progressive myelomalacia group and 16 in the control group). The mean CSF:L2SSTSEattenuation value was significantly higher in dogs that developed progressive myelomalacia (CSF:L2SSTSE= 10.7) compared to controls (CSF:L2SSTSE= 5.4; P = 0.015). A cut off ratio of attenuation >7.4 provided optimal differentiation between groups in this study. Findings supported the conclusion that dogs with CSF:L2SSTSE≤ 7.4 are unlikely to develop progressive myelomalacia while dogs with CSF:L2SSTSE> 7.4 are indeterminate for progressive myelomalacia.
authors.affiliation: Veterinary Clinical Sciences Department, College of Veterinary Medicine, Iowa State University, 1600 South 16th Street, Ames, IA, 50011.|Veterinary Large Animal Clinical Sciences, College of Veterinary Medicine, Texas A&M University, 4475 TAMU, College Station, TX, 77845-4475.
authors.forename: Lindsey J
authors.identifier: http://orcid.org/0000-0002-5521-8301
authors.initials: LJ
authors.lastname: Gilmour
authors.affiliation: Veterinary Clinical Sciences Department, College of Veterinary Medicine, Iowa State University, 1600 South 16th Street, Ames, IA, 50011.
authors.forename: Nick D
authors.initials: ND
authors.lastname: Jeffery
authors.affiliation: Veterinary Clinical Sciences Department, College of Veterinary Medicine, Iowa State University, 1600 South 16th Street, Ames, IA, 50011.
authors.forename: Kristina
authors.initials: K
authors.lastname: Miles
authors.affiliation: Veterinary Clinical Sciences Department, College of Veterinary Medicine, Iowa State University, 1600 South 16th Street, Ames, IA, 50011.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Riedesel
mesh_terms: D000818:Animals; D015331:Cohort Studies; D004283:Dog Diseases / Q000000981:diagnostic imaging*; D004285:Dogs; D005260:Female; D007238:Infarction / Q000000981:diagnostic imaging / Q000209:etiology / Q000662:veterinary*; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging*; D008279:Magnetic Resonance Imaging / Q000662:veterinary*; D008297:Male; D012189:Retrospective Studies; D013116:Spinal Cord / Q000098:blood supply* / Q000000981:diagnostic imaging; D013118:Spinal Cord Diseases / Q000000981:diagnostic imaging / Q000662:veterinary*
keywords: MRI; canine; progressive ascending myelomalacia; single-shot turbo spin echo; spinal cord