title: Serum vitamin D levels during activation and remission periods of patients with juvenile idiopathic arthritis and familial Mediterranean fever.
abstract: The aim of this study was to determine the frequency of vitamin D deficiency and/or insufficiency in children with juvenile idiopathic arthritis (JIA) and familial Mediterranean fever (FMF) and to assess the relationship between vitamin D and disease activity. Sixty four patients with JIA, thirty six patients with FMF and one hundred healthy children were enrolled in this study. Vitamin D levels were measured during activation and remission periods in the patients with JIA and during attack and attack free periods in the patients with FMF. The mean vitamin D levels were found to be 18. 9±11 ng/ml and 18.6±9.2 ng/ml during activation and remission periods of disease, respectively, in the patients with JIA, 16±8.5 ng/ml and 13.1±6.4 ng/ml during attack and attack-free periods, respectively, in the patients with FMF and 26.7±10.5 ng/ml in the healthy children. There was no significant difference between vitamin D levels during activation and remission periods in the patients with JIA, whereas vitamin D levels during attack free periods were lower compared to attack periods in the patients with FMF. No significant relationship was found between disease activity and serum vitamin D levels. The vitamin D levels of the children with JIA and FMF were significantly lower compared to the healthy children. The frequency of vitamin D deficiency and insufficiency was considerably high among the patients with JIA and FMF.
authors.affiliation: Division of Pediatric Endocrinology, İstanbul University Cerrahpasa Faculty of Medicine, Istanbul, Turkey.
authors.forename: Aydilek
authors.initials: A
authors.lastname: Dağdeviren-Çakır
authors.affiliation: Division of Social Pediatrics an, İstanbul University Cerrahpasa Faculty of Medicine, Istanbul, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Arvas
authors.affiliation: Division of Pediatric Rheumatology, İstanbul University Cerrahpasa Faculty of Medicine, Istanbul, Turkey.
authors.forename: Kenan
authors.initials: K
authors.lastname: Barut
authors.affiliation: Division of Social Pediatrics an, İstanbul University Cerrahpasa Faculty of Medicine, Istanbul, Turkey.
authors.forename: Emel
authors.initials: E
authors.lastname: Gür
authors.affiliation: Division of Pediatric Rheumatology, İstanbul University Cerrahpasa Faculty of Medicine, Istanbul, Turkey.
authors.forename: Özgür
authors.initials: Ö
authors.lastname: Kasapçopur
mesh_terms: D000293:Adolescent; D001171:Arthritis, Juvenile / Q000097:blood* / Q000150:complications; D002648:Child; D003430:Cross-Sectional Studies; D010505:Familial Mediterranean Fever / Q000097:blood* / Q000150:complications; D005260:Female; D006801:Humans; D008297:Male; D015995:Prevalence; D014807:Vitamin D / Q000097:blood*; D014808:Vitamin D Deficiency / Q000097:blood / Q000453:epidemiology*
chemical_list: D014807:Vitamin D
keywords: children; disease activity; familial Mediterranean fever; juvenile idiopathic arthrtitis; vitamin D