title: Utility of Microdialysis in Infectious Disease Drug Development and Dose Optimization.
abstract: Adequate drug penetration to a site of infection is absolutely imperative to ensure sufficient antimicrobial treatment. Microdialysis is a minimally invasive, versatile technique, which can be used to study the penetration of an antiinfective agent in virtually any tissue of interest. It has been used to investigate drug distribution and pharmacokinetics in variable patient populations, as a tool in dose optimization, a potential utility in therapeutic drug management, and in the study of biomarkers of disease progression. While all of these applications have not been fully explored in the field of antiinfectives, this review provides an overview of how microdialysis has been applied in various phases of drug development, a focus on the specific applications in the subspecialties of infectious disease (treatment of bacterial, fungal, viral, parasitic, and mycobacterial infections), and developing applications (biomarkers and therapeutic drug management).
authors.affiliation: Department of Pharmaceutics, University of Florida, 1345 Center Drive, PO Box 100494, Gainesville, Florida, 32610, USA.
authors.forename: Amelia N
authors.initials: AN
authors.lastname: Deitchman
authors.affiliation: Department of Pharmaceutics, University of Florida, 1345 Center Drive, PO Box 100494, Gainesville, Florida, 32610, USA.
authors.forename: M Tobias
authors.initials: MT
authors.lastname: Heinrichs
authors.affiliation: Department of Pharmaceutics, University of Florida, 1345 Center Drive, PO Box 100494, Gainesville, Florida, 32610, USA.
authors.forename: Vipada
authors.initials: V
authors.lastname: Khaowroongrueng
authors.affiliation: Department of Pharmaceutics, University of Florida, 1345 Center Drive, PO Box 100494, Gainesville, Florida, 32610, USA.
authors.forename: Satyawan B
authors.initials: SB
authors.lastname: Jadhav
authors.affiliation: Department of Pharmaceutics, University of Florida, 1345 Center Drive, PO Box 100494, Gainesville, Florida, 32610, USA. hartmut@ufl.edu.
authors.forename: Hartmut
authors.initials: H
authors.lastname: Derendorf
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D015415:Biomarkers / Q000378:metabolism; D003141:Communicable Diseases / Q000188:drug therapy / Q000382:microbiology; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D006801:Humans; D017551:Microdialysis / Q000379:methods*; D014018:Tissue Distribution
chemical_list: D000890:Anti-Infective Agents; D015415:Biomarkers
keywords: antibiotics; antivirals; drug penetration; pharmacodynamics; pharmacokinetics