title: Contribution of serum adipocyte fatty acid-binding protein levels to the presence of microalbuminuria in a Chinese hyperglycemic population.
abstract: OBJECTIVE
  Individuals with type 2 diabetes mellitus are vulnerable to micro- and macrovascular complications in the presence of microalbuminuria. Adipocyte fatty acid-binding protein (A-FABP) was proposed as an indicator for albuminuria in patients with diabetes. The present study aimed to explore the associations between serum A-FABP levels and microalbuminuria in the hyperglycemic population.
  
  
  METHODS
  Serum A-FABP levels were detected using sandwich enzyme-linked immunosorbent assay. Microalbuminuria was identified by urinary albumin-to-creatinine ratio (UACR), when the value was between 30-300 mg/g. The participants were divided into the subgroups based on sex and the status of impaired glucose regulation or newly diagnosed type 2 diabetes mellitus.
  
  
  RESULTS
  A total of 939 participants, consisting of 436 men and 503 women, were enrolled. Serum levels of A-FABP were much higher in participants with microalbuminuria than those without microalbuminuria. This result held true for all subgroups (all P < 0.05). For Spearman's correlation analyses, serum A-FABP levels showed a positive relationship with the UACR in men and women (both P < 0.01). Multiple stepwise regression analysis showed that serum A-FABP levels were independently and positively correlated with UACR in both sexes (men: standardized β = 0.256, P < 0.001; women: standardized β = 0.155, P = 0.001). This relationship remained significant in every subgroup (all P < 0.01).
  
  
  CONCLUSIONS
  For hyperglycemic individuals, serum A-FABP levels increased in the presence of microalbuminuria. Serum A-FABP levels were identified as an independent factor positively associated with the UACR.
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.|Shanghai Clinical Center for Diabetes, Shanghai, China.|Shanghai Key Clinical Center for Metabolic Disease, Shanghai, China.|Shanghai Diabetes Institute, Shanghai, China.|Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Hu
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.|Shanghai Clinical Center for Diabetes, Shanghai, China.|Shanghai Key Clinical Center for Metabolic Disease, Shanghai, China.|Shanghai Diabetes Institute, Shanghai, China.|Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Ma
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.|Shanghai Clinical Center for Diabetes, Shanghai, China.|Shanghai Key Clinical Center for Metabolic Disease, Shanghai, China.|Shanghai Diabetes Institute, Shanghai, China.|Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.
authors.forename: Yuqi
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.|Shanghai Clinical Center for Diabetes, Shanghai, China.|Shanghai Key Clinical Center for Metabolic Disease, Shanghai, China.|Shanghai Diabetes Institute, Shanghai, China.|Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.
authors.forename: Yiting
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.|Shanghai Clinical Center for Diabetes, Shanghai, China.|Shanghai Key Clinical Center for Metabolic Disease, Shanghai, China.|Shanghai Diabetes Institute, Shanghai, China.|Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Xiong
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.|Shanghai Clinical Center for Diabetes, Shanghai, China.|Shanghai Key Clinical Center for Metabolic Disease, Shanghai, China.|Shanghai Diabetes Institute, Shanghai, China.|Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Pan
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.|Shanghai Clinical Center for Diabetes, Shanghai, China.|Shanghai Key Clinical Center for Metabolic Disease, Shanghai, China.|Shanghai Diabetes Institute, Shanghai, China.|Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.
authors.forename: Yuqian
authors.initials: Y
authors.lastname: Bao
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.|Shanghai Clinical Center for Diabetes, Shanghai, China.|Shanghai Key Clinical Center for Metabolic Disease, Shanghai, China.|Shanghai Diabetes Institute, Shanghai, China.|Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.
authors.forename: Weiping
authors.initials: W
authors.lastname: Jia
mesh_terms: D000328:Adult; D000419:Albuminuria / Q000097:blood* / Q000150:complications / Q000652:urine; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000150:complications*; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D055815:Young Adult
chemical_list: C493410:FABP4 protein, human; D050556:Fatty Acid-Binding Proteins
keywords: Adipocyte fatty acid-binding protein; Microalbuminuria; Urinary albumin-to-creatinine ratio