title: Impact of highly active antiretroviral therapy in the development and remission of oral plasmablastic lymphoma.
abstract: Plasmablastic lymphoma (PBL) represents a rare type of non-Hodgkin lymphoma associated with human immunodeficiency virus (HIV) infection. The impact of highly active antiretroviral therapy (HAART) in this tumor is poorly known due to its small incidence. This study reports a case of a 33-year-old HIV-positive woman who was referred to the Stomatology Department complaining about a painful gingival growth and cervical nodule both with 20 days of evolution. The lesions appeared 7 months after the patient stopped HAART. The final diagnosis was PBL. After resuming HAART for 45 days, the gingival lesion presented complete remission. The patient continued with HAART alongside chemotherapy. At 24 months follow-up, the patient was stable. The dental surgeon plays an essential role in orientation and retention in care of HIV patients once the adherence of HAART seems to play an important role in PBL development and response to treatment.
authors.affiliation: Department of Oral Pathology, School of Dentistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, 90035-003, Brazil.
authors.forename: Vivian Petersen
authors.initials: VP
authors.lastname: Wagner
authors.affiliation: Department of Oral Pathology, School of Dentistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, 90035-003, Brazil.
authors.forename: Lisley
authors.initials: L
authors.lastname: Ortiz
authors.affiliation: Department of Oral Pathology, School of Dentistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, 90035-003, Brazil.
authors.forename: Helena Pereira Rodrigues
authors.initials: HP
authors.lastname: da Silva
authors.affiliation: Department of Pathology, Universidade Federal do Rio Grande do Sul, Hospital de Clinicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, 90035-903, Brazil.
authors.forename: Luise
authors.initials: L
authors.lastname: Meurer
authors.affiliation: Department of Oral Surgery, School of Dentistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, 90035-003, Brazil.
authors.forename: João Julio
authors.initials: JJ
authors.lastname: da Cunha Filho
authors.affiliation: Department of Oral Diagnosis, Universidade Federal do Rio Grande do Sul, Hospital de Clinicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, 90035-903, Brazil.
authors.forename: Marco Antonio Trevizani
authors.initials: MA
authors.lastname: Martins
authors.affiliation: Department of Oral Pathology, School of Dentistry, Universidade Federal do Rio Grande do Sul; Department of Oral Diagnosis, Universidade Federal do Rio Grande do Sul, Hospital de Clinicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, 90035-903, Brazil.
authors.forename: Manoela Domingues
authors.initials: MD
authors.lastname: Martins
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D009062:Mouth Neoplasms / Q000188:drug therapy / Q000209:etiology*; D000069293:Plasmablastic Lymphoma / Q000188:drug therapy / Q000209:etiology*; D012074:Remission Induction
chemical_list: D019380:Anti-HIV Agents