title: Irritable Bowel Syndrome: Pathophysiology and Current Therapeutic Approaches.
abstract: Irritable bowel syndrome (IBS) is a prevalent condition affecting 10-20% of adults in most countries; IBS results in significant morbidity and health care costs. IBS is a disorder of the brain-gut axis, and recent insights into the pathophysiological mechanisms include altered bile acid metabolism, neurohormonal regulation, immune dysfunction, alterations in the epithelial barrier, and secretory properties of the gut. There remains a significant unmet need for effective treatments, particularly for the pain component of IBS, although the introduction of drugs directed at secretion, motility, and a nonabsorbable antibiotic provides an option for the bowel dysfunction in IBS.
authors.affiliation: Department of Medicine, Pharmacology, and Physiology, Division of Gastroenterology, Mayo Clinic College of Medicine, Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.), 200 First Street S.W, Rochester, MN, 55905, USA. camilleri.michael@mayo.edu.
authors.forename: Michael
authors.initials: M
authors.lastname: Camilleri
authors.affiliation: Department of Gastroenterology and Honorary Consultant Gastroenterologist, Leeds Institute of Biomedical and Clinical Sciences, University of Leeds and Leeds Gastroenterology Institute, Leeds Teaching Hospitals Trust, Leeds, UK.
authors.forename: Alexander C
authors.initials: AC
authors.lastname: Ford
mesh_terms: D000818:Animals; D050528:Diet, Carbohydrate-Restricted; D055050:Diet, Gluten-Free; D004040:Dietary Carbohydrates / Q000009:adverse effects / Q000378:metabolism; D004043:Dietary Fiber / Q000008:administration & dosage; D017615:Enteric Nervous System / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D015444:Exercise; D005285:Fermentation; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000187:drug effects* / Q000294:innervation / Q000503:physiopathology*; D043183:Irritable Bowel Syndrome / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D040242:Risk Reduction Behavior; D016896:Treatment Outcome
chemical_list: D004040:Dietary Carbohydrates; D004043:Dietary Fiber; D005765:Gastrointestinal Agents
keywords: Irritable bowel syndrome; Pharmacotherapy