title: Liver Cancer Checks in When Bile Acid Clocks Out.
abstract: In this issue of Cancer Cell, Kettner et al. identify the disruption of normal circadian rhythmicity as an independent risk factor for hepatocellular carcinoma (HCC) in experimental animals and reveal opposing roles for the nuclear receptors FXR and CAR in disease progression from non-alcoholic fatty liver disease (NAFLD) to HCC.
authors.affiliation: Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
authors.forename: Ting
authors.initials: T
authors.lastname: Fu
authors.affiliation: Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
authors.forename: Xuan
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA; Howard Hughes Medical Institute, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: evans@salk.edu.
authors.forename: Ronald M
authors.initials: RM
authors.lastname: Evans
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism*; D006528:Carcinoma, Hepatocellular / Q000453:epidemiology*; D002940:Circadian Rhythm; D018450:Disease Progression; D006801:Humans; D015994:Incidence; D008113:Liver Neoplasms / Q000453:epidemiology*; D065626:Non-alcoholic Fatty Liver Disease / Q000150:complications* / Q000378:metabolism; D012307:Risk Factors
chemical_list: D001647:Bile Acids and Salts