title: Estradiol and Cognition in the Cardiovascular Risk Factors, Aging and Dementia (CAIDE) Cohort Study.
abstract: Cardiovascular Risk factors, Aging and Dementia (CAIDE) is a Finnish population-based study. 731 cognitively normal women had self-reported hormone therapy (HT) data in 1998 as: no use, use ≤5 years, and >5 years. Information on type of HT was only available from 1995-1998 (Prescription Register). Cognition was assessed in 1998 and 2005-2008. Long-term (>5 years) HT use, especially use of estradiol alone among women having hysterectomy with bilateral oophorectomy, was associated with better episodic memory in 1998, but not in 2005-2008. Although a strong evidence for protective effect of estradiol on cognition was not observed in our study, improved global cognition among long-term users suggests that long-term postmenopausal HT may be beneficial for some cognitive domains.
authors.affiliation: Institute of Clinical Medicine-Neurology, University of Eastern Finland, Kuopio, Finland.
authors.forename: Bushra
authors.initials: B
authors.lastname: Imtiaz
authors.affiliation: Research Center for Comparative Effectiveness and Patient Safety (RECEPS) and School of Pharmacy, University of Eastern Finland, Kuopio, Finland.
authors.forename: Anna Maija
authors.initials: AM
authors.lastname: Tolppanen
authors.affiliation: Institute of Clinical Medicine-Neurology, University of Eastern Finland, Kuopio, Finland.|Karolinska Institutet Center for Alzheimer Research, Stockholm, Sweden.
authors.forename: Alina
authors.initials: A
authors.lastname: Solomon
authors.affiliation: Institute of Clinical Medicine-Neurology, University of Eastern Finland, Kuopio, Finland.|Neurocenter, Neurology, Kuopio University Hospital, Kuopio, Finland.
authors.forename: Hilkka
authors.initials: H
authors.lastname: Soininen
authors.affiliation: Department of Neurology, University of Eastern Finland, Kuopio, Finland.|National Institute for Health and Welfare, Helsinki, Finland.|Aging Research Center (ARC) and center for Alzheimer Research, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
authors.forename: Miia
authors.initials: M
authors.lastname: Kivipelto
mesh_terms: D000368:Aged; D000375:Aging / Q000187:drug effects* / Q000523:psychology; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D003071:Cognition / Q000187:drug effects*; D003704:Dementia / Q000453:epidemiology*; D004958:Estradiol / Q000627:therapeutic use*; D005260:Female; D005387:Finland; D005500:Follow-Up Studies; D020249:Hormone Replacement Therapy; D006801:Humans; D007044:Hysterectomy; D008137:Longitudinal Studies; D061212:Memory, Episodic; D009483:Neuropsychological Tests; D010052:Ovariectomy; D017698:Postmenopause; D011446:Prospective Studies; D012307:Risk Factors; D057566:Self Report
chemical_list: D004958:Estradiol
keywords: Cognition; dementia; estradiol; hormone therapy; menopause