title: Fabrication and evaluation of chitosan/NaYF4:Yb3+/Tm3+upconversion nanoparticles composite beads based on the gelling of Pickering emulsion droplets.
abstract: The rare earth ion doped upconversion nanoparticles (UCNPs) synthesized by hydrophobic organic ligands possess poor solubility and low fluorescence quantum yield in aqueous media. To conquer this issue, NaYF4:Yb3+/Tm3+UCNPs, synthesized by a hydrothermal method, were coated with F127 and then assembled with chitosan to fabricate the chitosan/NaYF4:Yb3+/Tm3+composite beads (CS/NaYF4:Yb3+/Tm3+CBs) by Pickering emulsion system. The characterization results revealed that the as-synthesized NaYF4:Yb3+/Tm3+UCNPs with an average size of 20nm exhibited spherical morphology, high crystallinity and characteristic emission upconversion fluorescence with an overall blue color output. The NaYF4:Yb3+/Tm3+UCNPs were successfully conjugated on the surface of chitosan beads by the gelling of emulsion droplets. The resultant CS/NaYF4:Yb3+/Tm3+CBs showed good upconversion luminescent property, drug-loading capacity, release performance and excellent biocompatibility, exhibiting great potentials in targeted drug delivery and tissue engineering with potential tracking capability and lasting release performance.
authors.affiliation: College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571100, China.
authors.forename: Huiqiong
authors.initials: H
authors.lastname: Yan
authors.affiliation: College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571100, China.
authors.forename: Xiuqiong
authors.initials: X
authors.lastname: Chen
authors.affiliation: College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571100, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Shi
authors.affiliation: College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571100, China.
authors.forename: Zaifeng
authors.initials: Z
authors.lastname: Shi
authors.affiliation: College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571100, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Sun
authors.affiliation: College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571100, China. Electronic address: linqianggroup@163.com.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Lin
authors.affiliation: College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571100, China.
authors.forename: Xianghui
authors.initials: X
authors.lastname: Wang
authors.affiliation: College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571100, China.
authors.forename: Zihao
authors.initials: Z
authors.lastname: Dai
mesh_terms: D048271:Chitosan / Q000737:chemistry*; D004353:Drug Evaluation, Preclinical; D004655:Emulsions; D005459:Fluorides / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D013932:Thulium / Q000737:chemistry*; D015018:Ytterbium / Q000737:chemistry*; D015019:Yttrium / Q000737:chemistry*
chemical_list: D004655:Emulsions; C525362:sodium yttriumtetrafluoride; D015019:Yttrium; D013932:Thulium; D048271:Chitosan; D015018:Ytterbium; D005459:Fluorides
keywords: Chitosan; Composite beads; Luminescent property; NaYF(4):Yb(3+)/Tm(3+); Pickering emulsion; Upconversion nanoparticles