title: An Outbreak of Diarrhea in Mandera, Kenya, Due toEscherichia coliSerogroup O-Nontypable Strain That Had a Coding Gene for EnteroaggregativeE. coliHeat-Stable Enterotoxin 1.
abstract: In an outbreak of gastroenteritis in December 2009, in Mandera, Kenya,Escherichia coliO-nontypable (ONT) strain was isolated from stool specimens of patients (18/24, 75%). TheE. coliONT organisms could not be assigned to any of the recognized diarrheagenic groups ofE. coliHowever, they possessed the enteroaggregativeE. coliheat-stable enterotoxin-1 gene. The cell-free culture filtrates of theE. coliONT strain isolated from the outbreak cases induced considerable amount of fluid accumulation in suckling mouse intestine, indicating production of an enterotoxic factor(s). These results identifyE. colithat did not have any diarrheagenic characteristics exceptastAas the etiological agent of the diarrheal outbreak in Mandera. It is however considered necessary to characterize the fluid accumulation factor(s) to determine whether any novel toxins were responsible for the fluid accumulation. Moreover, it is important to study dissemination of strains producing the enterotoxic factor(s) to assess their public health significance distribution in the environment.
authors.affiliation: Fujita Health University, Toyoake, Japan.
authors.forename: Sadayuki
authors.initials: S
authors.lastname: Ochi
authors.affiliation: Nagasaki University Institute of Tropical Medicine, Kenya Research Station, Nairobi, Kenya.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Shah
authors.affiliation: Nagasaki University Institute of Tropical Medicine, Kenya Research Station, Nairobi, Kenya.
authors.forename: Erick
authors.initials: E
authors.lastname: Odoyo
authors.affiliation: Nagasaki University Institute of Tropical Medicine, Kenya Research Station, Nairobi, Kenya.
authors.forename: Martin
authors.initials: M
authors.lastname: Bundi
authors.affiliation: Nagasaki University Institute of Tropical Medicine, Kenya Research Station, Nairobi, Kenya.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Miringu
authors.affiliation: Kenya Medical Research Institute, Nairobi, Kenya.
authors.forename: Sora
authors.initials: S
authors.lastname: Guyo
authors.affiliation: Nagasaki University Institute of Tropical Medicine, Kenya Research Station, Nairobi, Kenya.
authors.forename: Ernest
authors.initials: E
authors.lastname: Wandera
authors.affiliation: Nagasaki University Institute of Tropical Medicine, Kenya Research Station, Nairobi, Kenya.
authors.forename: Cyrus
authors.initials: C
authors.lastname: Kathiiko
authors.affiliation: Kenya Medical Research Institute, Nairobi, Kenya.
authors.forename: Samuel
authors.initials: S
authors.lastname: Kariuki
authors.affiliation: Kenya Medical Research Institute, Nairobi, Kenya.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Karama
authors.affiliation: Nagasaki University Institute of Tropical Medicine, Kenya Research Station, Nairobi, Kenya.
authors.forename: Takao
authors.initials: T
authors.lastname: Tsuji
authors.affiliation: Nagasaki University Institute of Tropical Medicine, Kenya Research Station, Nairobi, Kenya. ichinose@nagasaki-u.ac.jp.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Ichinose
mesh_terms: D003967:Diarrhea / Q000453:epidemiology*; D004196:Disease Outbreaks; D004768:Enterotoxins / Q000235:genetics*; D004926:Escherichia coli / Q000235:genetics* / Q000302:isolation & purification*; D004927:Escherichia coli Infections / Q000453:epidemiology* / Q000235:genetics*; D006801:Humans; D007630:Kenya / Q000453:epidemiology; D065288:Serogroup; D014774:Virulence
chemical_list: D004768:Enterotoxins