title: Analysis of metabolism-related indicators and MTHFR gene polymorphism in patients with H-type hypertension.
abstract: BACKGROUND
  This study aims to analyze the polymorphism of the methylene tetrahydrofolate reductase (MTHFR) gene in patients with hypertension, and explore the correlation between H-type hypertension and metabolic biochemical indicators such as homocysteine (Hcy).
  
  
  METHODS
  One hundred patients with H-type hypertension and 100 patients with common hypertension were selected as the study subjects. Plasma Hcy and blood lipids, blood glucose, and other biochemical indicators were detected in the two groups. Then, the polymorphism of the MTHFR gene was compared between these two groups.
  
  
  RESULTS
  Hcy, uric acid (UA) and creatinine (Cr) levels in the H-type hypertension group were significantly higher than those of the common hypertension group (t=4.832-14.989, P<0.05). The T allele was predominant in the MTHFR 677C/T genotype frequency distribution in the H-type hypertension group, while the C allele was predominantly in the frequency distribution in the common hypertension group (P<0.05).
  
  
  CONCLUSIONS
  High levels of Hcy, UA and Cr are closely related to the occurrence of H-type hypertension. Homozygous mutant TT genotype of 677C/T of the MTHFR gene may be an important genetic factor of H-type hypertension.
authors.affiliation: Department of Otolaryngology, First Affiliated Hospital of Jinan University, Guangzhou, China.|Department of Otolaryngology, Affiliated Hospital of Southern Medical University, First People's Hospital of Shunde, Shunde, China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Tang
authors.affiliation: Department of Medicine, Affiliated Hospital of the First People's Hospital of Shunde, Xingtan Hospital, Shunde, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Xiao
authors.affiliation: Department of Medicine, Affiliated Hospital of the First People's Hospital of Shunde, Xingtan Hospital, Shunde, China.
authors.forename: Ji-Qun
authors.initials: JQ
authors.lastname: Wang
authors.affiliation: Department of Otolaryngology, First Affiliated Hospital of Jinan University, Guangzhou, China - zhangtao0240@163.com.
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D001786:Blood Glucose; D003404:Creatinine / Q000097:blood*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006710:Homocysteine / Q000097:blood*; D006720:Homozygote; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000145:classification / Q000235:genetics*; D008055:Lipids / Q000097:blood; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D014527:Uric Acid / Q000097:blood*
chemical_list: D001786:Blood Glucose; D008055:Lipids; D006710:Homocysteine; D014527:Uric Acid; D003404:Creatinine; D042965:Methylenetetrahydrofolate Reductase (NADPH2)