title: Vitamin E supplementation modulates the biological effects of omega-3 fatty acids in naturally aged rats.
abstract: Omega-3 fatty acids are well-known class of nutraceuticals with established health benefits. Recently, the oxidation products of these fatty acids are gaining attention, as they are likely to disturb body redox balance. Therefore, the efficacy of omega-3 fats under conditions of diminished antioxidant status, such as aging, is always a concern. Present study assessed the effects of omega-3 fats (DHA and EPA) together with or without vitamin-E in naturally aged rats. It was found that in omega-3 fats alone consumed rats the lipid profile was improved, while in omega-3 fat with vitamin-E-consumed group (OMVE), the hepato protective and antioxidant properties were pronounced, especially the redox status of brain tissue. It is possible that vitamin-E might have reduced the peroxidation of omega-3 fats, thereby allowing their synergistic effects. Hence, the use of vitamin-E along with omega-3 fat may be beneficial under aged conditions.
authors.affiliation: a Department of Biochemistry , Amala Cancer Research Centre (recognized by University of Calicut) , Thrissur , Kerala , India.
authors.forename: Arunaksharan
authors.initials: A
authors.lastname: Narayanankutty
authors.affiliation: a Department of Biochemistry , Amala Cancer Research Centre (recognized by University of Calicut) , Thrissur , Kerala , India.
authors.forename: Anagha
authors.initials: A
authors.lastname: Kottekkat
authors.affiliation: a Department of Biochemistry , Amala Cancer Research Centre (recognized by University of Calicut) , Thrissur , Kerala , India.
authors.forename: Shaji E
authors.initials: SE
authors.lastname: Mathew
authors.affiliation: a Department of Biochemistry , Amala Cancer Research Centre (recognized by University of Calicut) , Thrissur , Kerala , India.
authors.forename: Soorya P
authors.initials: SP
authors.lastname: Illam
authors.affiliation: a Department of Biochemistry , Amala Cancer Research Centre (recognized by University of Calicut) , Thrissur , Kerala , India.
authors.forename: Indu M
authors.initials: IM
authors.lastname: Suseela
authors.affiliation: a Department of Biochemistry , Amala Cancer Research Centre (recognized by University of Calicut) , Thrissur , Kerala , India.
authors.forename: Achuthan C
authors.initials: AC
authors.lastname: Raghavamenon
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D004357:Drug Synergism; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D017208:Rats, Wistar; D014810:Vitamin E / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D015525:Fatty Acids, Omega-3; D014810:Vitamin E
keywords: Omega-3 fatty acid; aging; antioxidants; oxidative stress; vitamin E