title: Post-exposure prophylaxis guidelines for children and adolescents potentially exposed to HIV.
abstract: UK guidelines for HIV post-exposure prophylaxis (PEP) in adults have recently been updated. Indications for PEP have been modified and there has been a change in the recommended antiretroviral therapy for adults to a combination of raltegravir with tenofovir and emtricitabine (Truvada). Raltegravir and tenofovir are now available in paediatric formulations and offer improved safety and tolerability over previously recommended ritonavir-boosted lopinavir with zidovudine. This guideline provides recommendations for those caring for children potentially exposed to HIV and other bloodborne viruses in primary care, emergency departments, secondary care and specialist paediatric HIV centres.
authors.affiliation: Department of Paediatric Infectious Diseases, Great Ormond Street Hospital for Children NHS Trust, London, UK.
authors.forename: Alasdair
authors.initials: A
authors.lastname: Bamford
authors.affiliation: Department of Paediatric Infectious Diseases, St Mary's Hospital, Imperial College Healthcare NHS Trust, London, UK.
authors.forename: Gareth
authors.initials: G
authors.lastname: Tudor-Williams
authors.affiliation: Department of Paediatric Infectious Diseases, St Mary's Hospital, Imperial College Healthcare NHS Trust, London, UK.
authors.forename: Caroline
authors.initials: C
authors.lastname: Foster
mesh_terms: D000293:Adolescent; D000359:Aftercare; D000553:Ambulatory Care; D019380:Anti-HIV Agents / Q000627:therapeutic use; D000932:Antiemetics / Q000627:therapeutic use; D002648:Child; D060085:Coinfection / Q000150:complications / Q000517:prevention & control; D017714:Community-Acquired Infections / Q000517:prevention & control; D003281:Contraceptives, Postcoital; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000517:prevention & control*; D019694:Hepatitis B, Chronic / Q000150:complications / Q000517:prevention & control; D019698:Hepatitis C, Chronic / Q000150:complications / Q000517:prevention & control; D006801:Humans; D016602:Needlestick Injuries / Q000517:prevention & control; D056990:Post-Exposure Prophylaxis / Q000379:methods*; D018570:Risk Assessment / Q000379:methods
chemical_list: D019380:Anti-HIV Agents; D000932:Antiemetics; D003281:Contraceptives, Postcoital
keywords: Children; Guideline; HIV; Post exposure; Prophylaxis