title: Cellular defence or viral assist: the dilemma of HDAC6.
abstract: Histone deacetylase 6 (HDAC6) is a unique cytoplasmic deacetylase that regulates various important biological processes by preventing protein aggregation and deacetylating different non-histone substrates including tubulin, heat shock protein 90, cortactin, retinoic acid inducible gene I and β-catenin. Growing evidence has indicated a dual role for HDAC6 in viral infection and pathogenesis: HDAC6 may represent a host defence mechanism against viral infection by modulating microtubule acetylation, triggering antiviral immune response and stimulating protective autophagy, or it may be hijacked by the virus to enhance proinflammatory response. In this review, we will highlight current data illustrating the complexity and importance of HDAC6 in viral pathogenesis. We will summarize the structure and functional specificity of HDAC6, and its deacetylase- and ubiquitin-dependent activity in key cellular events in response to virus infection. We will also discuss how HDAC6 exerts its direct or indirect histone modification ability in viral lytic-latency switch.
authors.affiliation: Department of Pharmacy, School of Medicine, Shenzhen University, Shenzhen 518060, PR China.|College of Life Science and Technology, Guangzhou Jinan Biomedicine Research and Development Center, Jinan University, Guangzhou 510632, PR China.
authors.forename: Kai
authors.initials: K
authors.lastname: Zheng
authors.affiliation: Department of Pharmacy, School of Medicine, Shenzhen University, Shenzhen 518060, PR China.
authors.forename: Yingchun
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Department of Pharmacy, School of Medicine, Shenzhen University, Shenzhen 518060, PR China.
authors.forename: Zhendan
authors.initials: Z
authors.lastname: He
authors.affiliation: Division of Molecular Pharmacology of Infectious Agents, Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan.
authors.forename: Kaio
authors.initials: K
authors.lastname: Kitazato
authors.affiliation: College of Life Science and Technology, Guangzhou Jinan Biomedicine Research and Development Center, Jinan University, Guangzhou 510632, PR China.
authors.forename: Yifei
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000818:Animals; D002465:Cell Movement; D002467:Cell Nucleus / Q000821:virology; D000073864:Histone Deacetylase 6; D006655:Histone Deacetylases / Q000737:chemistry / Q000502:physiology*; D006657:Histones / Q000378:metabolism; D006801:Humans; D007111:Immunity, Cellular; D008870:Microtubules / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D025801:Ubiquitin / Q000378:metabolism; D014777:Virus Diseases / Q000201:enzymology* / Q000821:virology*; D018406:Virus Physiological Phenomena
chemical_list: D006657:Histones; D025801:Ubiquitin; C433811:HDAC6 protein, human; D000073864:Histone Deacetylase 6; D006655:Histone Deacetylases