title: Anti-TNF-α for necrotizing sarcoid granulomatosis of the liver.
abstract: We present a case of hepatosplenic necrotizing sarcoid granulomatosis, a variant form of "classical" sarcoidosis, that became clinically apparent in the form of multiple hepatic and splenic masses mimicking malignancy. Flow cytometry of intrahepatic T cells isolated from liver biopsy led to the targeted treatment with anti-tumor necrosis factor-alpha, which was highly effective in inducing remission. (Hepatology 2017;65:1410-1412).
authors.affiliation: 1st Department of Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
authors.forename: Marcial
authors.initials: M
authors.lastname: Sebode
authors.affiliation: Department of Pathology, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
authors.forename: Sören
authors.initials: S
authors.lastname: Weidemann
authors.affiliation: 1st Department of Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
authors.forename: Malte
authors.initials: M
authors.lastname: Wehmeyer
authors.affiliation: 1st Department of Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
authors.forename: Ansgar W
authors.initials: AW
authors.lastname: Lohse
authors.affiliation: 1st Department of Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Schramm
mesh_terms: D000328:Adult; D001707:Biopsy, Needle; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006099:Granuloma / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D000069285:Infliximab / Q000008:administration & dosage*; D007262:Infusions, Intravenous; D008107:Liver Diseases / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009336:Necrosis / Q000473:pathology; D011379:Prognosis; D012507:Sarcoidosis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
chemical_list: D014409:Tumor Necrosis Factor-alpha; D000069285:Infliximab