title: Lipoprotein-associated phospholipase A2 in coronary heart disease: Review and meta-analysis.
abstract: BACKGROUND
  Risk associations between lipoprotein-associated phospholipase A2 (Lp-PLA2) and adverse outcomes in patients with coronary heart disease (CHD) remain unclear. The aim of the meta-analysis was to investigate the association between Lp-PLA2 and prognosis of CHD.
  
  
  METHODS
  PubMed and Embase were examined for prospective studies published before June 2016. Multivariate-adjusted hazard ratios (HRs) with 95% confidence intervals (CIs) for the risk of adverse outcomes according to Lp-PLA2 activity or mass were extracted, pooled, and weighted using generic inverse-variance and random-effect modeling.
  
  
  RESULTS
  Fifteen studies with 30,857 participants were included. Overall, higher Lp-PLA2 activity or mass was not significantly related to increased risk of long-term all-cause mortality. However, higher Lp-PLA2 activity or mass was independently associated with an increased risk of long-term cardiovascular events, with pooled HR for cardiovascular events of 1.55 (95% CI, 1.08-2.23; P=0.018) and 1.62 (95% CI, 1.09-2.41; P=0.017), respectively. The prognostic value of Lp-PLA2 in predicting cardiovascular events was observed in patients with stable CHD who were not receiving therapies for inhibiting Lp-PLA2.
  
  
  CONCLUSIONS
  Greater Lp-PLA2 activity or mass was independently associated with cardiovascular events in patients with CHD, particularly in patients with stable CHD who were not receiving therapies for inhibiting Lp-PLA2.
authors.affiliation: Department of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Dongze
authors.initials: D
authors.lastname: Li
authors.affiliation: Department of Cardiology, Second Affiliated Hospital of Southwest Medical University, Luzhou, China.
authors.forename: Lizhi
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Yu
authors.affiliation: Department of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Rongsheng
authors.initials: R
authors.lastname: Du
authors.affiliation: Department of Pharmacology, Harbin Medical University, Harbin, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Emergency Medicine, First Affiliated Hospital of Southwest Medical University, Luzhou, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
authors.forename: You
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Zeng
authors.affiliation: Department of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Cao
authors.affiliation: Department of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Zeng
authors.affiliation: West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, China. Electronic address: zzw2002400@126.com.
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Zhao
authors.affiliation: West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, China. Electronic address: jw@scu.edu.cn.
authors.forename: Jiang
authors.initials: J
authors.lastname: Wu
mesh_terms: D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood; D003327:Coronary Disease / Q000188:drug therapy / Q000201:enzymology* / Q000401:mortality*; D006801:Humans; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase; C526684:PLA2G7 protein, human
keywords: Cardiovascular events; Coronary heart disease; Lipoprotein-associated phospholipase A2; Meta-analysis; Mortality