title: Circulating miRNAs and miRNA shuttles as biomarkers: Perspective trajectories of healthy and unhealthy aging.
abstract: Human aging is a lifelong process characterized by a continuous trade-off between pro-and anti-inflammatory responses, where the best-adapted and/or remodeled genetic/epigenetic profile may develop a longevity phenotype. Centenarians and their offspring represent such a phenotype and their comparison to patients with age-related diseases (ARDs) is expected to maximize the chance to unravel the genetic makeup that better associates with healthy aging trajectories. Seemingly, such comparison is expected to allow the discovery of new biomarkers of longevity together with risk factor for the most common ARDs. MicroRNAs (miRNAs) and their shuttles (extracellular vesicles in particular) are currently conceived as those endowed with the strongest ability to provide information about the trajectories of healthy and unhealthy aging. We review the available data on miRNAs in aging and underpin the evidence suggesting that circulating miRNAs (and cognate shuttles), especially those involved in the regulation of inflammation (inflamma-miRs) may constitute biomarkers capable of reliably depicting healthy and unhealthy aging trajectories.
authors.affiliation: Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Via Tronto 10/A, Ancona, Italy; Center of Clinical Pathology and Innovative Therapy, Italian National Research Center on Aging, INRCA-IRCCS, Ancona, Italy.
authors.forename: Fabiola
authors.initials: F
authors.lastname: Olivieri
authors.affiliation: DIMES- Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum, Via S. Giacomo, 12, Bologna, Italy; CIG, Interdepartmental Center "L. Galvani", Alma Mater Studiorum, Pzza Porta S. Donato, 1, Bologna, Italy. Electronic address: miriam.capri@unibo.it.
authors.forename: Miriam
authors.initials: M
authors.lastname: Capri
authors.affiliation: DIMES- Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum, Via S. Giacomo, 12, Bologna, Italy.
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Bonafè
authors.affiliation: DIMES- Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum, Via S. Giacomo, 12, Bologna, Italy; CIG, Interdepartmental Center "L. Galvani", Alma Mater Studiorum, Pzza Porta S. Donato, 1, Bologna, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Morsiani
authors.affiliation: Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, United States.
authors.forename: Hwa Jin
authors.initials: HJ
authors.lastname: Jung
authors.affiliation: Center of Clinical Pathology and Innovative Therapy, Italian National Research Center on Aging, INRCA-IRCCS, Ancona, Italy.
authors.forename: Liana
authors.initials: L
authors.lastname: Spazzafumo
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Valencia. INCLIVA Avda, Blasco Ibañez 15, 46010 Valencia, Spain.
authors.forename: Jose
authors.initials: J
authors.lastname: Viña
authors.affiliation: Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, United States.
authors.forename: Yousin
authors.initials: Y
authors.lastname: Suh
mesh_terms: D000375:Aging / Q000097:blood* / Q000235:genetics / Q000473:pathology; D000818:Animals; D015415:Biomarkers / Q000097:blood; D000067128:Extracellular Vesicles / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000235:genetics; D035683:MicroRNAs / Q000097:blood* / Q000235:genetics
chemical_list: D015415:Biomarkers; D035683:MicroRNAs
keywords: Aging trajectories; Centenarians; Circulating microRNAs; Offspring of centenarians; miR-21-5p