title: [Specificities of carcinomas in adolescents and young adults].
abstract: Carcinomas are rare tumors of the adolescent-young adult (AYA) with a different spectrum from those of adults. The most common sites outside of the thyroid is the nasopharynx, salivary gland, colon-rectum and ovaries. If nasopharyngeal carcinoma or salivary gland tumors are good prognosis, others are more reserved prognosis, such as digestive carcinomas, gynecological or midline. The revelation modes are non-specific and depend on the location: mass, tumor syndrome, pain, impaired general condition. The unusual of pediatric carcinomas led to propose a systematic oncogenetic exploration. The medical history of the family, the symptoms and the type of the carcinoma should guide the analysis. In the absence of guidance, analysis of TP53 gene and, for carcinomas of the expanded spectrum of the hereditary non-polyposis colorectal cancer (HNPCC) syndrome, the search for mutation of MMR genes (mismatch repair) seems essential. Because of the rarity of these diseases and the absence of homogeneous recommendations, members of the rare tumors committee of the SFCE recommended for the management of these AJA, an histological review by a pathologist familiar with carcinomas of the adult, a double discussion between pediatric and adult oncologists, analysis of adult standards with adaptation to pediatric data, especially in terms of risk of side effects. An advice to a national opinion (by a member of FRACTURE group) or European (group EXPERT) is sometimes necessary in the most complex situations.
authors.affiliation: Université Paris-Saclay, Institut Gustave-Roussy, département de cancérologie de l'enfant et de l'adolescent, 114, rue Édouard-Vaillant, 94800 Villejuif, France.
authors.forename: Brice
authors.initials: B
authors.lastname: Fresneau
authors.affiliation: Université Paris-Saclay, Institut Gustave-Roussy, département de cancérologie de l'enfant et de l'adolescent, 114, rue Édouard-Vaillant, 94800 Villejuif, France.
authors.forename: Marie-Emilie
authors.initials: ME
authors.lastname: Dourthe
authors.affiliation: Centre Oscar-Lambret, département de radiothérapie, 3, rue Frédéric-Combemale, 59000 Lille, France.
authors.forename: Anaïs
authors.initials: A
authors.lastname: Jouin
authors.affiliation: Institut Curie, département d'oncologie médicale, 26, rue d'Ulm, 75005 Paris, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Laurence
authors.affiliation: AP-HP, hôpitaux universitaires Paris Sud, hôpital Bicêtre, département de chirurgie pédiatrique, 78, rue du Général-Leclerc, 94270 Le Kremlin-Bicêtre, France.
authors.forename: Guénolée
authors.initials: G
authors.lastname: de Lambert
authors.affiliation: AP-HP, groupe hospitalier Pitié-Salpêtrière, hôpital La Pitié-Salpétrière, UF d'oncogénétique et d'angiogénétique, 47-83, boulevard de l'Hôpital, 75013 Paris, France.
authors.forename: Christelle
authors.initials: C
authors.lastname: Colas
authors.affiliation: CHU Pellegrin, service de chirurgie gynécologique, place Amélie-Raba-Léon, 33076 Bordeaux, France.
authors.forename: Mathilde
authors.initials: M
authors.lastname: Coret
authors.affiliation: Université Paul-Sabatier Toulouse III, 118, route de Narbonne, 31062 Toulouse, France; Institut universitaire du cancer de Toulouse-Oncopole, avenue Hubert-Curien, 31100 Toulouse, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Laprie
authors.affiliation: Fondation Adolphe-de-Rothschild, ENT and cervico-facial surgery department, 29, rue Manin, 75019 Paris, France.
authors.forename: Céleste
authors.initials: C
authors.lastname: Rebours
authors.affiliation: Institut Curie, département de pédiatrie - adolescents-jeunes adultes, Groupe français « FRACTURE » des tumeurs rares de l'enfant de la Société française des cancers de l'enfant (SFCE), 26, rue d'Ulm, 75005 Paris, France.
authors.forename: Daniel
authors.initials: D
authors.lastname: Orbach
authors.affiliation: Université Paris-Saclay, Institut Gustave-Roussy, U1018, centre d'épidémiologie et de santé des populations (CESP), Institut national de la santé et de la recherche médicale (Inserm), 114, rue Édouard-Vaillant, 94800 Villejuif, France. Electronic address: c.demoor@hotmail.fr.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Demoor-Goldschmidt
mesh_terms: D000293:Adolescent; D000367:Age Factors; D001943:Breast Neoplasms / Q000175:diagnosis / Q000628:therapy; D002277:Carcinoma / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000628:therapy; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000628:therapy; D008297:Male; D009303:Nasopharyngeal Neoplasms / Q000175:diagnosis / Q000628:therapy; D009369:Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000628:therapy; D011379:Prognosis; D012468:Salivary Gland Neoplasms / Q000175:diagnosis / Q000628:therapy; D012737:Sex Factors; D013953:Thymus Neoplasms / Q000175:diagnosis / Q000628:therapy; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000628:therapy; D055815:Young Adult
keywords: Adolescent; Breast cancer; Carcinoma; Carcinome; Carcinome colorectal; Carcinome des glandes salivaires; Carcinome du sein; Carcinome indifférencié du nasopharynx; Colorectal carcinoma; Salivary gland carcinoma; Undifferentiated carcinoma of the nasopharyngeal tract