title: Considerations about gastric cancer proteomics.
abstract: The frequency of molecular studies aimed to analyze promoter methylation of tumor suppressor genes and global proteomics in gastric carcinogenesis is increasing. Nonetheless, only a few considered the different types of stomach cells, the tumor location and the influence of Helicobacter pylori and Epstein Barr virus infection (EBV). Molecular differences relating to anatomical and histological tumor areas were also recently described. The authors propose a molecular classification of gastric cancer, dividing it into four subtypes: tumors positive for EBV; microsatellite unstable tumors; genomically stable tumors and tumors with chromosomal instability. RESUMO A frequência de estudos moleculares visando a analisar os promotores de metilação de genes supressores de tumor e proteômica globais na carcinogênese gástrica está aumentando. No entanto, apenas alguns consideraram os diferentes tipos de células do estômago, a localização do tumor e a influência da infecção por Helicobacter pylori e pelo vírus Epstein-Barr (EBV). Diferenças moleculares relacionadas com áreas tumorais anatômicas e histológicas também foram recentemente descritas. Os autores propõem uma classificação molecular de câncer gástrico, dividindo-o em quatro subtipos: tumores positivos para o EBV; tumores microssatélite instáveis; tumores genomicamente estáveis ​​e tumores com instabilidade cromossômica.
authors.affiliation: Department of Pathology, Faculty of Medicine, Federal University of Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Carlos Eduardo
authors.initials: CE
authors.lastname: Carvalho
authors.affiliation: Department of Pathology, Faculty of Medicine, Federal University of Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Thaís Messias
authors.initials: TM
authors.lastname: McCormick
authors.affiliation: Laboratory for Proteomics and Protein Engineering, Instituto Carlos Chagas, Fiocruz, Curitiba, PR, Brazil.
authors.forename: Paulo Costa
authors.initials: PC
authors.lastname: Carvalho
authors.affiliation: Laboratory for Proteomics and Protein Engineering, Instituto Carlos Chagas, Fiocruz, Curitiba, PR, Brazil.
authors.forename: Juliana DE Saldanha DA Gama
authors.initials: JS
authors.lastname: Fischer
authors.affiliation: Institute Leônidas and Maria Deane, Fiocruz, Amazonas, AM, Brazil.
authors.forename: Priscila Ferreira DE
authors.initials: PF
authors.lastname: Aquino
authors.affiliation: Department of Surgery, Faculty of Medicine, Federal University of Rio de Janeiro, RJ, Brazil.
authors.forename: Guilherme Pinto
authors.initials: GP
authors.lastname: Bravo
authors.affiliation: Department of Pathology, Faculty of Medicine, Federal University of Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Maria DA Glória DA Costa
authors.initials: MD
authors.lastname: Carvalho
mesh_terms: D006801:Humans; D040901:Proteomics; D013274:Stomach Neoplasms / Q000145:classification*