title: Spirodalesol, an NLRP3 Inflammasome Activation Inhibitor.
abstract: Autoimmune and inflammatory diseases are associated with inappropriate activation of the NOD-like receptor protein 3 (NLRP3) inflammasome, but suitable inhibitors against such improper activations remain scarce. Here, spirodalesol (1) from Daldinia eschscholzii was structurally characterized and is biosynthetically proposed as an NLRP3 inflammasome activation inhibitor with an unprecedented carbon skeleton.
authors.affiliation: Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University , Nanjing 210046, China.|State Key Laboratory of Elemento-organic Chemistry, Nankai University , Tianjin 300071, China.
authors.forename: Ai Hua
authors.initials: AH
authors.lastname: Zhang
authors.affiliation: Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University , Nanjing 210046, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Liu
authors.affiliation: School of Pharmacy, Nanjing Medical University , Nanjing 210029, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Jiang
authors.affiliation: Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University , Nanjing 210046, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Xu
authors.affiliation: Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University , Nanjing 210046, China.|School of Pharmacy, Nanjing University of Chinese Medicine , Nanjing 210023, China.
authors.forename: Ren Xiang
authors.identifier: 0000-0001-6532-6261
authors.initials: RX
authors.lastname: Tan
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D058847:Inflammasomes / Q000037:antagonists & inhibitors* / Q000378:metabolism; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D008958:Models, Molecular; D015394:Molecular Structure; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein / Q000037:antagonists & inhibitors* / Q000378:metabolism; D061065:Polyketides / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013098:Xylariales / Q000737:chemistry*
chemical_list: D058847:Inflammasomes; D008070:Lipopolysaccharides; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; C492716:Nlrp3 protein, mouse; D061065:Polyketides; C000627747:spirodalesol