title: Biochemical Changes in the Niche Following Tumor Cell Invasion.
abstract: Metastatic cancer is the leading cause of all cancer related deaths. Prostate cancer (PCa) metastasizes preferentially to the bone marrow, specifically within the endosteal niche. Endosteal cells secrete homing molecules that may recruit PCa cells to the bone marrow. Once there, the biochemical signature of this niche regulates PCa fate including cellular dormancy or cell cycle arrest, reactivation and resistance to chemotherapeutics. Growth factors, interleukins, adhesion molecules, as well as extra-cellular matrix proteins can collectively change the phenotype of PCa cells. Understanding the biochemical signature of endosteal niche parasitism by PCa is imperative for the establishment of new and innovative therapeutic strategies. This review seeks to summarize these important niche signatures and the potential therapeutic approaches to target metastatic PCa within the bone marrow hematopoietic stem cell (HSC) niche. J. Cell. Biochem. 118: 1956-1964, 2017. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan.
authors.forename: A M
authors.initials: AM
authors.lastname: Decker
authors.affiliation: Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan.|Division of Hematology and Oncology, Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, Michigan.
authors.forename: F C
authors.initials: FC
authors.lastname: Cackowski
authors.affiliation: Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan.
authors.forename: Y
authors.initials: Y
authors.lastname: Jung
authors.affiliation: Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan.
authors.forename: R S
authors.initials: RS
authors.lastname: Taichman
mesh_terms: D001853:Bone Marrow / Q000276:immunology / Q000473:pathology*; D019046:Bone Marrow Neoplasms / Q000235:genetics* / Q000276:immunology / Q000556:secondary; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000276:immunology; D002465:Cell Movement; D016326:Extracellular Matrix Proteins / Q000235:genetics / Q000276:immunology; D015972:Gene Expression Regulation, Neoplastic; D006412:Hematopoietic Stem Cells / Q000276:immunology / Q000473:pathology*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics / Q000276:immunology; D007378:Interleukins / Q000235:genetics / Q000276:immunology; D008297:Male; D009360:Neoplastic Cells, Circulating / Q000276:immunology / Q000473:pathology; D010521:Periosteum / Q000276:immunology / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D015398:Signal Transduction; D055153:Stem Cell Niche / Q000235:genetics* / Q000276:immunology
chemical_list: D015815:Cell Adhesion Molecules; D016326:Extracellular Matrix Proteins; D036341:Intercellular Signaling Peptides and Proteins; D007378:Interleukins
keywords: DISSEMINATED TUMOR CELL (DTC); METASTASIS; NICHE; OSTEOBLAST; PROSTATE CANCER (PCa)