title: Simultaneous screening and detection of pharmaceutical co-crystals by the one-step DSC-FTIR microspectroscopic technique.
abstract: Various methods and analytical techniques for the preparation and identification of pharmaceutical co-crystals have been applied, but these operations require considerable time for the screening and preparation of co-crystals. In this review, a powerful method that combines Fourier-transform infrared (FTIR) microspectroscopy with thermal analysis is introduced. This unique one-step real-time differential scanning calorimetry (DSC)-FTIR microspectroscopic approach has been successfully applied to simultaneously and directly screen and detect pharmaceutical co-crystal formation in systems such as indomethacin-saccharin, indomethacin-nicotinamide, carbamazepine-glutaric-acid, metaxalone-succinic-acid and piroxicam-saccharin. This powerful one-step DSC-FTIR combined technique provides an easy and direct method for one-step screening and qualitative detection of co-crystal formation in real time.
authors.affiliation: Department of Biotechnology and Pharmaceutical Technology, Yuanpei University of Medical Technology, Hsin Chu, Taiwan, ROC. Electronic address: sylin@mail.ypu.edu.tw.
authors.forename: Shan-Yang
authors.initials: SY
authors.lastname: Lin
mesh_terms: D002152:Calorimetry, Differential Scanning / Q000379:methods*; D003460:Crystallization / Q000379:methods; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods*
chemical_list: D004364:Pharmaceutical Preparations