title: The new Bruch's membrane opening - minimum rim width classification improves optical coherence tomography specificity in tilted discs.
abstract: OBJECTIVE
  To investigate and compare the false-positive (FP) diagnostic classification of the Bruch's membrane opening - minimum rim width (BMO-MRW) and retinal nerve fiber layer (RNFL) thickness in healthy eyes with tilted optic disc.
  
  
  METHODS
  Fifty healthy eyes of 30 participants with tilted optic disc underwent BMO-MRW and RNFL scanning using Spectralis and macular Cirrus optical coherence tomography (OCT) scans.
  
  
  RESULTS
  The overall FP rate was significantly lower using BMO-MRW map compared with both RNFL map by Spectralis (8% vs 62%, respectively,P<0.001) and ganglion cell analysis (GCA) map by Cirrus (8% vs 50%, respectively,P<0.001). Specificity was significantly higher using BMO-MRW than RNFL in eyes with low (89.7% vs 41.4%,P<0.001) and moderate myopia (95.2% vs 33.3%,P<0.001).
  
  
  CONCLUSIONS
  OCT-derived BMO-MRW analysis provides significantly greater specificity than RNFL in tilted disc irrespectively of the refractive error, and it is more specific than GCA analysis in tilted disc with moderate myopia.
authors.affiliation: Department of Ophthalmology, Hospital Universitario Ramón y Cajal, Madrid, Spain.
authors.forename: Gema
authors.initials: G
authors.lastname: Rebolleda
authors.affiliation: Department of Ophthalmology, Hospital Universitario Ramón y Cajal, Madrid, Spain.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Casado
authors.affiliation: Department of Ophthalmology, Hospital Universitario Ramón y Cajal, Madrid, Spain.
authors.forename: Noelia
authors.initials: N
authors.lastname: Oblanca
authors.affiliation: Department of Ophthalmology, Hospital Universitario Ramón y Cajal, Madrid, Spain.
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Muñoz-Negrete
keywords: Bruch membrane; false-positive; optical coherence tomography; tilted disc