title: Strontium Ranelate Effect on the Repair of Bone Defects and Molecular Components of the Cortical Bone of Rats.
abstract: This study was conducted to evaluate the effects of treatment with strontium ranelate (SR) on the repair of bone defects and molecular components of bones in femurs. Adult female rats (n=27) were subjected to ovariectomy (OVX) or Sham surgery. Thirty days after surgery, a defect was made in the femur and the animals were then divided into three groups: OVX, SHAM and OVX+SR. Euthanasia was performed four weeks after the bone defect surgery. Repair in bone defect was assessed by computed microtomography (μCT) and chemical composition of cortical bone was analyzed by Fourier transform infrared (FTIR) spectroscopy and energy dispersive X-ray spectroscopy (EDS). The trabecular thickness (Tb.Th) of the newly formed bone in the OVX+SR group was significantly higher than that for the OVX group. The collagen maturity in the OVX+SR group was smaller than in the other two groups. In this group, a significant increase in the amount of strontium (Sr) and a decrease in the amount of calcium (Ca) embedded to bone tissue were also observed. Systemic treatment with SR improved microarchitecture of the newly formed bone inside the defect, but decreased cross-linking of mature collagen in cortical bone.
authors.affiliation: Department of Stomatology, Dental School, USP - Universidade de São Paulo, São Paulo, SP, Brazil.
authors.forename: Jucely Aparecida da
authors.initials: JA
authors.lastname: Rosa
authors.affiliation: Institute for Research and Development, UNIVAP - Universidade do Vale do Paraíba, SP, Brazil.
authors.forename: Kumiko Koibuchi
authors.initials: KK
authors.lastname: Sakane
authors.affiliation: Department of Stomatology, Dental School, USP - Universidade de São Paulo, São Paulo, SP, Brazil.
authors.forename: Karina Cecília Panelli
authors.initials: KC
authors.lastname: Santos
authors.affiliation: Department of Orthopaedic Surgery, New York University School of Medicine, New York, NY, USA.
authors.forename: Vivian Bradaschia
authors.initials: VB
authors.lastname: Corrêa
authors.affiliation: Department of Biomaterials and Oral Biology, Dental School, USP - Universidade de São Paulo, São Paulo, SP, Brazil.
authors.forename: Victor Elias
authors.initials: VE
authors.lastname: Arana-Chavez
authors.affiliation: Department of Stomatology, Dental School, USP - Universidade de São Paulo, São Paulo, SP, Brazil.
authors.forename: Jefferson Xavier de
authors.initials: JX
authors.lastname: Oliveira
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000187:drug effects*; D005260:Female; D010052:Ovariectomy; D051381:Rats; D017208:Rats, Wistar; D017550:Spectroscopy, Fourier Transform Infrared; D013057:Spectrum Analysis / Q000379:methods; D013876:Thiophenes / Q000494:pharmacology*
chemical_list: D013876:Thiophenes; C081587:strontium ranelate