title: Allimacrosides A-E, new steroidal glycosides from Allium macrostemon Bunge.
abstract: A new pregnane-type steroidal glycoside (1), two new spirostane-type steroidal glycosides (2, 3), and two new furostane-type steroidal glycosides (4, 5), named allimacrosides A-E, together with four known compounds (6-9) were isolated from a 80% MeOH extract of Allium macrostemon Bunge. The identification and structural elucidation of these compounds were based on their 1D- and 2D-NMR spectra, and HR-FAB-MS data analysis. The isolated compounds were tested for cytotoxicity against four human tumor cell lines in vitro using the sulforhodamine B bioassay.
authors.affiliation: Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
authors.forename: Yun Sik
authors.initials: YS
authors.lastname: Kim
authors.affiliation: Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
authors.forename: Won Se
authors.initials: WS
authors.lastname: Suh
authors.affiliation: Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
authors.forename: Kyoung Jin
authors.initials: KJ
authors.lastname: Park
authors.affiliation: Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea.
authors.forename: Sang Un
authors.initials: SU
authors.lastname: Choi
authors.affiliation: Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea. Electronic address: krlee@skku.edu.
authors.forename: Kang Ro
authors.initials: KR
authors.lastname: Lee
mesh_terms: D000490:Allium / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006027:Glycosides / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012235:Rhodamines / Q000737:chemistry / Q000494:pharmacology; D013256:Steroids / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D006027:Glycosides; D012235:Rhodamines; D013256:Steroids; C022027:lissamine rhodamine B
keywords: Allium macrostemon; Cytotoxicity; Liliaceae; Steroidal glucosides