title: Easy access to triazolinedione-endcapped peptides for chemical ligation.
abstract: An efficient and easy route towards triazolinedione (TAD) endcapped peptides is described, in which a TAD-precursor was coupled to N-terminal amines on a solid support. Modified peptides readily reacted with diene end-functionalized poly(ε-caprolactone) of different molecular weights. The ligation proved to be orthogonal to a variety of functional groups present in natural amino acids.
authors.affiliation: Department of Chemistry, Laboratory for Organic Synthesis of Functional Systems, Humboldt-Universität zu Berlin, Brook-Taylor-Str. 2, 12489 Berlin, Germany. h.boerner@hu-berlin.de patrick.wilke@hu-berlin.de.
authors.forename: P
authors.initials: P
authors.lastname: Wilke
authors.affiliation: Department of Chemistry, Laboratory for Organic Synthesis of Functional Systems, Humboldt-Universität zu Berlin, Brook-Taylor-Str. 2, 12489 Berlin, Germany. h.boerner@hu-berlin.de patrick.wilke@hu-berlin.de.
authors.forename: T
authors.initials: T
authors.lastname: Kunde
authors.affiliation: Department of Organic and Macromolecular Chemistry, Polymer Chemistry Research Group, Ghent University, Krijgslaan 281 S4-bis B-9000, Ghent, Belgium.
authors.forename: S
authors.initials: S
authors.lastname: Chattopadhyay
authors.affiliation: Department of Chemistry, Laboratory for Organic Synthesis of Functional Systems, Humboldt-Universität zu Berlin, Brook-Taylor-Str. 2, 12489 Berlin, Germany. h.boerner@hu-berlin.de patrick.wilke@hu-berlin.de.
authors.forename: N
authors.initials: N
authors.lastname: Ten Brummelhuis
authors.affiliation: Department of Organic and Macromolecular Chemistry, Polymer Chemistry Research Group, Ghent University, Krijgslaan 281 S4-bis B-9000, Ghent, Belgium.
authors.forename: F E
authors.initials: FE
authors.lastname: Du Prez
authors.affiliation: Department of Chemistry, Laboratory for Organic Synthesis of Functional Systems, Humboldt-Universität zu Berlin, Brook-Taylor-Str. 2, 12489 Berlin, Germany. h.boerner@hu-berlin.de patrick.wilke@hu-berlin.de.
authors.forename: H G
authors.identifier: 0000-0001-9333-9780
authors.initials: HG
authors.lastname: Börner
mesh_terms: D008970:Molecular Weight; D010455:Peptides / Q000737:chemistry*; D011091:Polyesters / Q000737:chemistry; D014230:Triazoles / Q000737:chemistry*
chemical_list: D010455:Peptides; D011091:Polyesters; D014230:Triazoles; C016240:polycaprolactone