title: Mesoporous silica nanoparticles functionalized with folic acid/methionine for active targeted delivery of docetaxel.
abstract: Mesoporous silica nanoparticles (MSNs) are known as carriers with high loading capacity and large functionalizable surface area for target-directed delivery. In this study, a series of docetaxel-loaded folic acid- or methionine-functionalized mesoporous silica nanoparticles (DTX/MSN-FA or DTX/MSN-Met) with large pores and amine groups at inner pore surface properties were prepared. The results showed that the MSNs were successfully synthesized, having good pay load and pH-sensitive drug release kinetics. The cellular investigation on MCF-7 cells showed better performance of cytotoxicity and cell apoptosis and an increase in cellular uptake of targeted nanoparticles. In vivo fluorescent imaging on healthy BALB/c mice proved that bare MSN-NH2are mostly accumulated in the liver but MSN-FA or MSN-Met are more concentrated in the kidney. Importantly, ex vivo fluorescent images of tumor-induced BALB/c mice organs revealed the ability of MSN-FA to reach the tumor tissues. In conclusion, DTX/MSNs exhibited a good anticancer activity and enhanced the possibility of targeted drug delivery for breast cancer.
authors.affiliation: Department of Pharmaceutics.
authors.forename: Pegah
authors.initials: P
authors.lastname: Khosravian
authors.affiliation: Department of Radiopharmacy.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Shafiee Ardestani
authors.affiliation: Department of Pharmaceutical Biomaterials.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Khoobi
authors.affiliation: Department of Pharmacology and Toxicology.
authors.forename: Seyed Naser
authors.initials: SN
authors.lastname: Ostad
authors.affiliation: Department of Pharmaceutics.
authors.forename: Farid Abedin
authors.initials: FA
authors.lastname: Dorkoosh
authors.affiliation: Department of Pharmaceutics.
authors.forename: Hamid
authors.initials: H
authors.lastname: Akbari Javar
authors.affiliation: Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center; Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Massoud
authors.initials: M
authors.lastname: Amanlou
keywords: docetaxel; folic acid; mesoporous silica nanoparticle; methionine; targeted delivery