title: The clinical significance of brain microbleeds in patients with Alzheimer's disease: Preliminary study.
abstract: BACKGROUND
  Microbleeds (MBs) are observed frequently in Alzheimer's disease (AD) and suggested to play a crucial role in the pathophysiology, but their clinical significance remains unclear.
  
  
  METHODS
  The study recruited 100 patients with AD who were diagnosed at the memory clinic in Seoul Medical Center in 2014. For each patient, baseline characteristics, neuropsychological tests, cerebrovascular risk factors, medial temporal lobe atrophy (MTLA), and severity of small vessel disease (SVD) according to the existence of MBs were evaluated.
  
  
  RESULTS
  The prevalence of MBs in patients with AD was 33%. The percentage of male gender, the severity of SVD and MTLA were significantly increased in MB(+) group. The MB(+) group showed more severe MTLA and SVD than MB(-) group.
  
  
  CONCLUSIONS
  These results suggested that MBs might reflect the burden of amyloid and ischemic vascular pathology.
authors.affiliation: Department of Neurology, Seoul Medical Center, Chungrang-gu, Seoul 131-130, Korea.
authors.forename: Jae-Hyeok
authors.initials: JH
authors.lastname: Heo
authors.affiliation: Department of Neurology, Seoul Medical Center, Chungrang-gu, Seoul 131-130, Korea.
authors.forename: Dong-Gyu
authors.initials: DG
authors.lastname: Im
authors.affiliation: Department of Neurology, Seoul Medical Center, Chungrang-gu, Seoul 131-130, Korea.
authors.forename: Seung-Hyeon
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Department of Neurology, Seoul Medical Center, Chungrang-gu, Seoul 131-130, Korea.
authors.forename: Jin-Young
authors.initials: JY
authors.lastname: Ahn
keywords: Alzheimer disease; cognition; microbleeds