title: The rs4646 and rs12592697 Polymorphisms inCYP19A1Are Associated with Disease Progression among Patients with Breast Cancer from Different Racial/Ethnic Backgrounds.
abstract: Given the racial/ethnic disparities in breast cancer, we evaluated the association betweenCYP19A1single nucleotide polymorphisms (SNPs) on disease progression in women with breast cancer from different racial/ethnic backgrounds. This is a cross-sectional analysis of data from 327 women with breast cancer in the Expanded Breast Cancer Registry program of the University of New Mexico. Stored DNA samples were analyzed forCYP19A1SNPs using a custom designed microarray panel. Genotype-phenotype correlations were analyzed. Of the 384 SNPs, 2 were associated with clinically significant outcomes, the rs4646 and rs12592697. The T allele for the rs4646 was associated with advanced stage of the disease at the time of presentation (odds ratio [OR]:1.8, confidence intervals [CI]: 1.05-3.13,p< 0.05) and a more progressive disease (OR: 2.1 [CI: 1.1-4.0],p= 0.04). For the rs12592697, the variant T allele was more frequent in Hispanic women and associated with a more progressive disease (OR: 2.05 [CI: 1.0-4.0],p= 0.04). However, further analysis according to menopausal status showed that the association between these 2 SNPs with disease progression or the stage at diagnosis are confined only to postmenopausal women. The odds ratios of disease progression among postmenopausal women carrying the T allele for the rs4646 and rs12592697 are 3.05 (1.21, 7.74,p= 0.02) and 3.80 (1.24, 11.6,p= 0.02), respectively. Regardless, differences in disease progression among the different genotypes for both SNPs disappeared after adjustment for treatment. In summary, the rs4646 and the rs12592697 SNPs inCYP19A1are associated with differences in disease progression in postmenopausal women. However, treatment appears to mitigate the differences in genetic risk.
authors.affiliation: Department of Internal Medicine, Baylor College of MedicineHouston, TX, USA; Department of Internal Medicine, Michael E. DeBakey VA Medical CenterHouston, TX, USA.
authors.forename: Reina
authors.initials: R
authors.lastname: Armamento-Villareal
authors.affiliation: Department of Biochemistry and Molecular Biology, University of New Mexico Health Science CenterAlbuquerque, NM, USA; New Mexico Tumor Registry, University of New Mexico Health Sciences CenterAlbuquerque, NM, USA.
authors.forename: Vallabh O
authors.initials: VO
authors.lastname: Shah
authors.affiliation: Department of Internal Medicine, New Mexico VA Health Care System Albuquerque, NM, USA.
authors.forename: Lina E
authors.initials: LE
authors.lastname: Aguirre
authors.affiliation: New Mexico Tumor Registry, University of New Mexico Health Sciences Center Albuquerque, NM, USA.
authors.forename: Angela L W
authors.initials: AL
authors.lastname: Meisner
authors.affiliation: Department of Mathematics, University of New Mexico Health Science Center Albuquerque, NM, USA.
authors.forename: Clifford
authors.initials: C
authors.lastname: Qualls
authors.affiliation: New Mexico Tumor Registry, University of New Mexico Health Sciences Center Albuquerque, NM, USA.
authors.forename: Melanie E
authors.initials: ME
authors.lastname: Royce
keywords: CYP19A1 polymorphisms; aromatase; breast cancer; racial disparity; women