title: Cytokine response to Hantaan virus infection in patients with hemorrhagic fever with renal syndrome.
abstract: Hantaan virus (HTNV) infection of the human body causes a severe acute infectious disease known as hemorrhagic fever renal syndrome (HFRS). The aim of this study was to correlate patient cytokine profiles to HFRS severity. In this study, we discuss the clinical significance of evaluating HFRS treatment outcomes using cytokine information. The levels of 18 cytokines were quantitatively determined in three groups: 34 HTNV IgM+ cases, 63 HTNV IgM- negative cases, and 78 healthy volunteers. The level of 14 serum cytokines were higher in the patient group than that in the healthy control group. In the 34 HTNV IgM+ patient sera, a set of 27 cytokines was further assessed. The cytokines of TNF-β, IL-1ra, and IL-6 were detected at higher level in the IgM+ group than that in the IgM- group. The deterioration of HFRS was accompanied with multiple cytokines increased, such as IL-1ra, IL-12p70, IL-10, IP-10, IL-17, IL-2, and IL-6. Our data indicate that serum cytokine levels are associated with the progression of HFRS.
authors.affiliation: Department of Immunology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China.|Department of Immunology, School of Medicine, Ji Shou University, Hunan, China.
authors.forename: Jing
authors.identifier: 0000-0002-7266-7707
authors.initials: J
authors.lastname: Guo
authors.affiliation: Department of Immunology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
authors.forename: Xuli
authors.initials: X
authors.lastname: Guo
authors.affiliation: Department of Immunology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Immunology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Tian
authors.affiliation: Department of Immunology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
authors.forename: Weiguang
authors.initials: W
authors.lastname: Luo
authors.affiliation: Department of Immunology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China.|The Cooperative Innovation Center of Engineering and New Products for Developmental Biology of Hunan Province, Hunan, China.
authors.forename: Yizhou
authors.initials: Y
authors.lastname: Zou
mesh_terms: D000328:Adult; D016207:Cytokines / Q000096:biosynthesis / Q000097:blood* / Q000276:immunology; D018450:Disease Progression; D005260:Female; D018063:Hantaan virus / Q000276:immunology*; D006480:Hemorrhagic Fever with Renal Syndrome / Q000097:blood / Q000188:drug therapy / Q000276:immunology* / Q000821:virology; D006760:Hospitalization; D006801:Humans; D007124:Immunoenzyme Techniques; D007075:Immunoglobulin M / Q000097:blood; D053590:Interleukin 1 Receptor Antagonist Protein / Q000097:blood; D016753:Interleukin-10 / Q000097:blood; D020381:Interleukin-17 / Q000097:blood / Q000276:immunology; D007376:Interleukin-2 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index
chemical_list: D016207:Cytokines; C508609:IL10 protein, human; C508717:IL17A protein, human; C507763:IL1RN protein, human; D007075:Immunoglobulin M; D053590:Interleukin 1 Receptor Antagonist Protein; D020381:Interleukin-17; D007376:Interleukin-2; D015850:Interleukin-6; D016753:Interleukin-10
keywords: cytokine; hantavirus; hemorrhagic fever renal syndrome