title: Serum miR-92a-3p as a New Potential Biomarker for Diagnosis of Kawasaki Disease with Coronary Artery Lesions.
abstract: Recent studies have suggested that serum microRNAs (miRNAs) are novel biomarkers for many cardiovascular diseases, but their role in Kawasaki disease (KD) is still unclear. We demonstrated that serum miR-92a-3p levels were significantly higher in children with KD compared with children with fever and controls (both P < 0.05). When the disease recovered, miR-92a-3p levels returned to those of controls. Clinical and pathological data showed that high levels of miR-92a-3p were significantly associated with coronary artery lesions (CALs). Analysis of the receiver operating characteristic (ROC) curve showed that serum miR-92a-3p had a sensitivity of 81.8% and a specificity of 66.7% for distinguishing KD with CALs from KD without CALs. The area under the curve was 0.816 (P < 0.05, 95% CI 0.669-0.962). Therefore, the miRNA miR-92a-3p may be used as a potential biomarker for diagnosis of KD and KD with coronary artery lesions.
authors.affiliation: Children's Heart Center, the Second Affiliated Hospital & Yuying Children's Hospital, Institute of Cardiovascular Development and Translational Medicine, Wenzhou Medical University, Wenzhou, 325027, Zhejiang, China.
authors.forename: Xing
authors.initials: X
authors.lastname: Rong
authors.affiliation: Department of Second Pediatrics, The People's Hospital of Langfang City, Langfang, 065000, Hebei, China.
authors.forename: Lianhong
authors.initials: L
authors.lastname: Jia
authors.affiliation: Children's Heart Center, the Second Affiliated Hospital & Yuying Children's Hospital, Institute of Cardiovascular Development and Translational Medicine, Wenzhou Medical University, Wenzhou, 325027, Zhejiang, China.
authors.forename: Lanlan
authors.initials: L
authors.lastname: Hong
authors.affiliation: Children's Heart Center, the Second Affiliated Hospital & Yuying Children's Hospital, Institute of Cardiovascular Development and Translational Medicine, Wenzhou Medical University, Wenzhou, 325027, Zhejiang, China.
authors.forename: Lulu
authors.initials: L
authors.lastname: Pan
authors.affiliation: Department of Microbiology and Immunology, Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China.
authors.forename: Xiangyang
authors.initials: X
authors.lastname: Xue
authors.affiliation: Department of Biomedical Engineering, School of Medicine, The University of Alabama at Birmingham, Birmingham, AL, 35233, USA.
authors.forename: Chunxiang
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Pediatrics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015, Zhejiang, China.
authors.forename: Jiacheng
authors.initials: J
authors.lastname: Lu
authors.affiliation: Department of Pediatrics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015, Zhejiang, China.
authors.forename: Zengyou
authors.initials: Z
authors.lastname: Jin
authors.affiliation: Children's Heart Center, the Second Affiliated Hospital & Yuying Children's Hospital, Institute of Cardiovascular Development and Translational Medicine, Wenzhou Medical University, Wenzhou, 325027, Zhejiang, China.
authors.forename: Huixian
authors.initials: H
authors.lastname: Qiu
authors.affiliation: Children's Heart Center, the Second Affiliated Hospital & Yuying Children's Hospital, Institute of Cardiovascular Development and Translational Medicine, Wenzhou Medical University, Wenzhou, 325027, Zhejiang, China. wrz71@hotmail.com.
authors.forename: Rongzhou
authors.initials: R
authors.lastname: Wu
authors.affiliation: Children's Heart Center, the Second Affiliated Hospital & Yuying Children's Hospital, Institute of Cardiovascular Development and Translational Medicine, Wenzhou Medical University, Wenzhou, 325027, Zhejiang, China. chmping@126.com.
authors.forename: Maoping
authors.initials: M
authors.lastname: Chu
mesh_terms: D019540:Area Under Curve; D016022:Case-Control Studies; D002478:Cells, Cultured; D002675:Child, Preschool; D003324:Coronary Artery Disease / Q000097:blood* / Q000175:diagnosis / Q000209:etiology / Q000235:genetics; D005260:Female; D005819:Genetic Markers; D061307:Human Umbilical Vein Endothelial Cells / Q000378:metabolism; D006801:Humans; D007223:Infant; D008297:Male; D035683:MicroRNAs / Q000097:blood* / Q000235:genetics; D009080:Mucocutaneous Lymph Node Syndrome / Q000097:blood* / Q000150:complications / Q000175:diagnosis / Q000235:genetics; D011237:Predictive Value of Tests; D012372:ROC Curve
chemical_list: D005819:Genetic Markers; C541874:MIRN92 microRNA, human; D035683:MicroRNAs
keywords: Biomarker; Coronary artery lesion; Kawasaki disease; MicroRNA