title: The psychometric properties of the Leicester Cough Questionnaire and Respiratory Symptoms in CF tool in cystic fibrosis: A preliminary study.
abstract: BACKGROUND
  There are few tools to quantify the impact of cough in cystic fibrosis (CF). The psychometric properties of the Leicester Cough Questionnaire (LCQ) and Respiratory Symptoms in CF (ReS-CF) tool were investigated in adults with CF.
  
  
  METHODS
  Validity and reliability were assessed in clinically stable participants who completed the questionnaires twice, along with the Cystic Fibrosis Questionnaire - Revised (CFQ-R). Responsiveness was assessed by change in questionnaires following treatment for an acute respiratory exacerbation.
  
  
  RESULTS
  Correlations between the LCQ and CFQ-R respiratory domain were moderate (n=59, rs=0.78, p<0.001). Correlations between ReS-CF and CFQ-R respiratory domain were fair (rs=-0.50, p<0.001). The LCQ total score was repeatable (ICC 0.92, 95%CI 0.87-0.96, n=50). In those reporting improvement in symptoms following treatment (n=36), LCQ total score had a mean change of 4.6 (SD 3.7) and effect size of 1.2.
  
  
  CONCLUSIONS
  The LCQ and ReS-CF appear to be valid, reliable and responsive in CF.
  
  
  BACKGROUND
  www.anzctr.org.au: ACTRN12615000262505.
authors.affiliation: Royal Adelaide Hospital, North Terrace, Adelaide 5000, Australia; La Trobe University, Melbourne 3004, Australia. Electronic address: nathan.ward2@sa.gov.au.
authors.forename: Nathan
authors.initials: N
authors.lastname: Ward
authors.affiliation: Central Adelaide Local Health Network, Adelaide 5000, Australia. Electronic address: kathy.stiller@sa.gov.au.
authors.forename: Kathy
authors.initials: K
authors.lastname: Stiller
authors.affiliation: Royal Adelaide Hospital, North Terrace, Adelaide 5000, Australia. Electronic address: hilary.rowe@sa.gov.au.
authors.forename: Hilary
authors.initials: H
authors.lastname: Rowe
authors.affiliation: La Trobe University, Melbourne 3004, Australia; Alfred Health, Commercial Road, Melbourne 3004, Australia. Electronic address: a.holland@latrobe.edu.au.
authors.forename: Anne E
authors.initials: AE
authors.lastname: Holland
mesh_terms: D000328:Adult; D001315:Australia; D003371:Cough / Q000503:physiopathology / Q000523:psychology; D003550:Cystic Fibrosis / Q000175:diagnosis / Q000503:physiopathology / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D011594:Psychometrics / Q000379:methods / Q000592:standards; D011788:Quality of Life; D015203:Reproducibility of Results; D012137:Respiratory System / Q000503:physiopathology; D011795:Surveys and Questionnaires
keywords: Cough; Cystic fibrosis; Leicester Cough Questionnaire; Signs and symptoms, respiratory; Surveys and questionnaires