title: Kidney volume and ambulatory blood pressure in children.
abstract: Low nephron number has been shown to be a risk factor for hypertension (HTN) in adulthood. Kidney volume may serve as a surrogate marker for nephron mass. The relationship between kidney volume and ambulatory blood pressure (BP) in the pediatric population is not known. A retrospective chart review of children younger than 21 years who were evaluated for HTN was performed. Twenty-four-hour BP and ultrasonography data were obtained. Multiple regression was used to examine associations between BP and kidney volume. Of 84 children (mean age 13.87 years, 72.6% males), 54 had HTN. Systolic BP index during the awake, sleep, and 24-hour periods (all P≤.05) was found to be positively correlated with total kidney volume. Greater total kidney volume was found to be a positive predictor of 24-hour and sleep systolic index (P≤.05). It failed to serve as a predictor of HTN, pre-HTN, or white-coat HTN. Contrary to expectation, total kidney volume was positively associated with systolic BP indices.
authors.affiliation: Division of Pediatric Nephrology, Department of Pediatrics, Cohen Children's Medical Center of New York, New Hyde Park, NY, USA.
authors.forename: Shari
authors.initials: S
authors.lastname: Gurusinghe
authors.affiliation: Department of Radiology, Northwell Health, New Hyde Park, NY, USA.
authors.forename: Arkadiy
authors.initials: A
authors.lastname: Palvanov
authors.affiliation: Division of Pediatric Radiology, NYU Langone Medical Center, New York, NY, USA.
authors.forename: Mark E
authors.initials: ME
authors.lastname: Bittman
authors.affiliation: Division of Pediatric Nephrology, Department of Pediatrics, Cohen Children's Medical Center of New York, New Hyde Park, NY, USA.
authors.forename: Pamela
authors.initials: P
authors.lastname: Singer
authors.affiliation: Division of Pediatric Nephrology, Department of Pediatrics, Cohen Children's Medical Center of New York, New Hyde Park, NY, USA.
authors.forename: Rachel
authors.initials: R
authors.lastname: Frank
authors.affiliation: Division of Pediatric Nephrology, Department of Pediatrics, Cohen Children's Medical Center of New York, New Hyde Park, NY, USA.
authors.forename: Nataliya
authors.initials: N
authors.lastname: Chorny
authors.affiliation: Division of Pediatric Nephrology, Department of Pediatrics, Cohen Children's Medical Center of New York, New Hyde Park, NY, USA.
authors.forename: Lulette
authors.initials: L
authors.lastname: Infante
authors.affiliation: Division of Pediatric Nephrology, Department of Pediatrics, Cohen Children's Medical Center of New York, New Hyde Park, NY, USA.
authors.forename: Christine B
authors.initials: CB
authors.lastname: Sethna
mesh_terms: D000293:Adolescent; D001794:Blood Pressure / Q000502:physiology*; D018660:Blood Pressure Monitoring, Ambulatory / Q000379:methods*; D002648:Child; D002940:Circadian Rhythm / Q000502:physiology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000145:classification / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology*; D007668:Kidney / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008297:Male; D009399:Nephrons / Q000166:cytology / Q000000981:diagnostic imaging*; D012189:Retrospective Studies; D012307:Risk Factors; D013599:Systole; D014463:Ultrasonography / Q000379:methods; D059466:White Coat Hypertension / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology
keywords: ambulatory blood pressure; hypertension; kidney volume; pediatric