title: Retrospective study of tadalafil for fetal growth restriction: Impact on maternal and perinatal outcomes.
abstract: OBJECTIVE
  The aim of this retrospective study was to assess tadalafil treatment in pregnant women with fetal growth restriction (FGR) in terms of maternal and perinatal outcomes.
  
  
  METHODS
  We retrospectively analyzed 11 Japanese singleton pregnant women with FGR who received tadalafil along with conventional management for FGR at Mie University Hospital from July 2015 to February 2016 (tadalafil group). These women were matched for maternal age, parity, gestational age, and estimated fetal weight at enrollment with 14 singleton pregnant women who received only the conventional management for FGR in 2014 (conventional management group). The conventional management for FGR was performed according to guidelines for obstetric practice in Japan.
  
  
  RESULTS
  Both birthweight and fetal growth velocity from enrollment to birth were significantly higher in the tadalafil group than in the conventional management group. The cesarean delivery rate was approximately twofold higher in the conventional management group than in the tadalafil group. Importantly, cesarean section due to non-reassuring fetal status was performed in seven pregnant women in the conventional management group (58.3%) but in none in the tadalafil group (P < 0.05, chi-squared test).
  
  
  CONCLUSIONS
  Tadalafil may improve perinatal outcome in FGR by modulating fetal growth through maintenance or improvement of fetal well-being.
authors.affiliation: Department of Obstetrics and Gynecology, Mie University Graduate School of Medicine, Tsu, Japan.
authors.forename: Michiko
authors.initials: M
authors.lastname: Kubo
authors.affiliation: Department of Obstetrics and Gynecology, Mie University Graduate School of Medicine, Tsu, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Umekawa
authors.affiliation: Department of Obstetrics and Gynecology, National Organization Mie Chuo Medical Center, Tsu, Japan.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Maekawa
authors.affiliation: Department of Obstetrics and Gynecology, Mie University Graduate School of Medicine, Tsu, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Tanaka
authors.affiliation: Department of Obstetrics and Gynecology, Mie University Graduate School of Medicine, Tsu, Japan.
authors.forename: Masafumi
authors.initials: M
authors.lastname: Nii
authors.affiliation: Department of Obstetrics and Gynecology, Mie University Graduate School of Medicine, Tsu, Japan.
authors.forename: Nao
authors.identifier: http://orcid.org/0000-0002-5799-6764
authors.initials: N
authors.lastname: Murabayashi
authors.affiliation: Department of Obstetrics and Gynecology, Mie University Graduate School of Medicine, Tsu, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Osato
authors.affiliation: Department of Obstetrics and Gynecology, Mie University Graduate School of Medicine, Tsu, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kamimoto
authors.affiliation: Department of Obstetrics and Gynecology, Mie University Graduate School of Medicine, Tsu, Japan.
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Ikeda
mesh_terms: D000328:Adult; D001724:Birth Weight / Q000187:drug effects*; D036861:Delivery, Obstetric; D005260:Female; D005317:Fetal Growth Retardation / Q000188:drug therapy*; D006801:Humans; D017063:Outcome Assessment, Health Care; D058986:Phosphodiesterase 5 Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D011247:Pregnancy; D012189:Retrospective Studies; D000068581:Tadalafil / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D058986:Phosphodiesterase 5 Inhibitors; D000068581:Tadalafil
keywords: fetal growth restriction; fetal growth velocity; phosphodiesterase 5 inhibitor; retrospective study; tadalafil