title: Simple prediction model for unfavorable outcome in ischemic stroke after intravenous thrombolytic therapy.
abstract: OBJECTIVE
  We aimed to develop a model to predict unfavorable outcome in patients with acute ischemic stroke treated with intravenous thrombolytic therapy (IVT), based on simple variables present on admission.
  
  
  METHODS
  Retrospective analysis of acute ischemic stroke patients treated with IVT in a hospital in Rio de Janeiro. Clinical and radiographic variables were selected for analysis. Multivariate logistic regression was used to develop a predictive model.
  
  
  RESULTS
  We analyzed a total of 82 patients. Median National Institutes of Health Stroke Scale (NIHSS) on admission was 9 (3-22), 40.2% presented with a hyperdense artery sign (HAS), 62% had identifiable early parenchymal changes and 61.6% experienced a favorable outcome. An NIHSS score of > 12 on arrival, age > 70 and the presence of HAS were associated with the outcome, even after correction in a logistic regression model.
  
  
  CONCLUSIONS
  An NIHSS > 12 on arrival, presence of HAS and age > 70 years were predictors of unfavorable outcome at three months in patients with acute ischemic stroke treated with IVT.
authors.affiliation: Hospital Copa D´Or, Unidade de Cuidado Neurointensivo, Rio de Janeiro RJ, Brasil.|Universidade Federal Fluminense, Departamento de Neurologia, Rio de Janeiro RJ, Brasil.
authors.forename: Daniel
authors.initials: D
authors.lastname: Amitrano
authors.affiliation: Universidade Federal Fluminense, Departamento de Neurologia, Rio de Janeiro RJ, Brasil.|Unidade Neurointensiva, Americas Medical Center, Rio de Janeiro, Brazil.
authors.forename: Ivan Rocha Ferreira da
authors.initials: IR
authors.lastname: Silva
authors.affiliation: Hospital Copa D´Or, Unidade de Cuidado Neurointensivo, Rio de Janeiro RJ, Brasil.|Unidade Neurointensiva, Americas Medical Center, Rio de Janeiro, Brazil.
authors.forename: Bernardo B
authors.initials: BB
authors.lastname: Liberato
authors.affiliation: Hospital Copa D´Or, Unidade de Cuidado Neurointensivo, Rio de Janeiro RJ, Brasil.
authors.forename: Valéria
authors.initials: V
authors.lastname: Batistella
authors.affiliation: Hospital Copa D´Or, Unidade de Cuidado Neurointensivo, Rio de Janeiro RJ, Brasil.
authors.forename: Janaina
authors.initials: J
authors.lastname: Oliveira
authors.affiliation: Universidade Federal Fluminense, Departamento de Neurologia, Rio de Janeiro RJ, Brasil.
authors.forename: Osvaldo J M
authors.initials: OJ
authors.lastname: Nascimento
mesh_terms: D000208:Acute Disease; D061605:Administration, Intravenous; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D005544:Forecasting; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D020521:Stroke / Q000188:drug therapy*; D015912:Thrombolytic Therapy; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D005343:Fibrinolytic Agents