title: Synthesis and physical chemical properties of 2-amino-4-(trifluoromethoxy)butanoic acid - a CF3O-containing analogue of natural lipophilic amino acids.
abstract: 2-Amino-2-(trifluoromethoxy)butanoic acid (O-trifluoromethyl homoserine) was synthesized as a racemate and in both enantiomeric forms. The measured pKaand log D values establish the compound as a promising analogue of natural aliphatic amino acids.
authors.affiliation: Enamine Ltd, Chervonotkatska St 78, Kyiv, 02094, Ukraine. vanya_ko@mail.ru and Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine, Murmanska Str. 1, Kyiv, 02660, Ukraine.
authors.forename: Ivan S
authors.initials: IS
authors.lastname: Kondratov
authors.affiliation: Enamine Ltd, Chervonotkatska St 78, Kyiv, 02094, Ukraine. vanya_ko@mail.ru and Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine, Murmanska Str. 1, Kyiv, 02660, Ukraine.
authors.forename: Ivan G
authors.initials: IG
authors.lastname: Logvinenko
authors.affiliation: Enamine Ltd, Chervonotkatska St 78, Kyiv, 02094, Ukraine. vanya_ko@mail.ru and Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine, Murmanska Str. 1, Kyiv, 02660, Ukraine.
authors.forename: Nataliya A
authors.initials: NA
authors.lastname: Tolmachova
authors.affiliation: Enamine Ltd, Chervonotkatska St 78, Kyiv, 02094, Ukraine. vanya_ko@mail.ru.
authors.forename: Roman N
authors.initials: RN
authors.lastname: Morev
authors.affiliation: Enamine Ltd, Chervonotkatska St 78, Kyiv, 02094, Ukraine. vanya_ko@mail.ru.
authors.forename: Maria A
authors.initials: MA
authors.lastname: Kliachyna
authors.affiliation: Organisch-Chemisches Institut, Universität Münster, Corrensstraße 40, Münster 48149, Germany. haufe@uni-muenster.de.
authors.forename: Florian
authors.initials: F
authors.lastname: Clausen
authors.affiliation: Organisch-Chemisches Institut, Universität Münster, Corrensstraße 40, Münster 48149, Germany. haufe@uni-muenster.de.
authors.forename: Constantin G
authors.initials: CG
authors.lastname: Daniliuc
authors.affiliation: Organisch-Chemisches Institut, Universität Münster, Corrensstraße 40, Münster 48149, Germany. haufe@uni-muenster.de and Cells-in-Motion Cluster of Excellence, Universität Münster, Waldeyerstraße 15, 48149 Münster, Germany.
authors.forename: Günter
authors.identifier: http://orcid.org/0000-0001-8437-9035
authors.initials: G
authors.lastname: Haufe
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry*; D002087:Butyrates / Q000138:chemical synthesis* / Q000737:chemistry*; D002627:Chemistry, Physical; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D008958:Models, Molecular; D015394:Molecular Structure
chemical_list: C000626551:2-amino-4-(trifluoromethoxy)butanoic acid; D000596:Amino Acids; D002087:Butyrates; D006845:Hydrocarbons, Fluorinated