title: Additive Interaction of MTHFR C677T and MTRR A66G Polymorphisms with Being Overweight/Obesity on the Risk of Type 2 Diabetes.
abstract: Although both methylenetetrahydrofolate reductase (MTHFR) C677T and methionine synthase reductase (MTRR) A66G polymorphisms have been associated with type 2 diabetes (T2D), their interactions with being overweight/obesity on T2D risk remain unclear. To evaluate the associations of the two polymorphisms with T2D and their interactions with being overweight/obesity on T2D risk, a case-control study of 180 T2D patients and 350 healthy controls was conducted in northern China. Additive interaction was estimated using relative excess risk due to interaction (RERI), attributable proportion due to interaction (AP) and synergy index (S). After adjustments for age and gender, borderline significant associations of theMTHFRC677T andMTRRA66G polymorphisms with T2D were observed under recessive (OR = 1.43, 95% CI: 0.98-2.10) and dominant (OR = 1.43, 95% CI: 1.00-2.06) models, respectively. There was a significant interaction between theMTHFR677TT genotype and being overweight/obesity on T2D risk (AP = 0.404, 95% CI: 0.047-0.761), in addition to theMTRR66AG/GG genotypes (RERI = 1.703, 95% CI: 0.401-3.004; AP = 0.528, 95% CI: 0.223-0.834). Our findings suggest that individuals with theMTHFR677TT orMTRR66AG/GG genotypes are more susceptible to the detrimental effect of being overweight/obesity on T2D. Further large-scale studies are still needed to confirm our findings.
authors.affiliation: Research Center of Environment and Non-Communicable Disease, School of Public Health, China Medical University, Shenyang 110122, China. zhixy90smile@126.com.
authors.forename: Xueyuan
authors.initials: X
authors.lastname: Zhi
authors.affiliation: Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China. yangby23@mail.sysu.edu.cn.
authors.forename: Boyi
authors.initials: B
authors.lastname: Yang
authors.affiliation: Research Center of Environment and Non-Communicable Disease, School of Public Health, China Medical University, Shenyang 110122, China. fanfan0721ykl@163.com.
authors.forename: Shujun
authors.initials: S
authors.lastname: Fan
authors.affiliation: Research Center of Environment and Non-Communicable Disease, School of Public Health, China Medical University, Shenyang 110122, China. liyongfang_17@163.com.
authors.forename: Yongfang
authors.initials: Y
authors.lastname: Li
authors.affiliation: Research Center of Environment and Non-Communicable Disease, School of Public Health, China Medical University, Shenyang 110122, China. hemiao.cmu@gmail.com.
authors.forename: Miao
authors.initials: M
authors.lastname: He
authors.affiliation: Research Center of Environment and Non-Communicable Disease, School of Public Health, China Medical University, Shenyang 110122, China. dwang@cmu.edu.cn.
authors.forename: Da
authors.initials: D
authors.lastname: Wang
authors.affiliation: Division of Molecular Preventive Medicine, Shanghai Institute of Targeted Therapy and Molecular Medicine, Shanghai 200433, China. wangyanxun@genechina.com.
authors.forename: Yanxun
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Brain Disease Center, Tianjin Dagang Oil Field General Hospital, Tianjin 300280, China. weijiantianjin@163.com.
authors.forename: Jian
authors.initials: J
authors.lastname: Wei
authors.affiliation: Research Center of Environment and Non-Communicable Disease, School of Public Health, China Medical University, Shenyang 110122, China. qmzheng@cmu.edu.cn.
authors.forename: Quanmei
authors.initials: Q
authors.lastname: Zheng
authors.affiliation: Research Center of Environment and Non-Communicable Disease, School of Public Health, China Medical University, Shenyang 110122, China. gfsun@cmu.edu.cn.
authors.forename: Guifan
authors.initials: G
authors.lastname: Sun
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002681:China; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005287:Ferredoxin-NADP Reductase / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology / Q000235:genetics; D050177:Overweight / Q000453:epidemiology / Q000235:genetics*; D011110:Polymorphism, Genetic; D012306:Risk
chemical_list: C111241:methionine synthase reductase; D005287:Ferredoxin-NADP Reductase; D042965:Methylenetetrahydrofolate Reductase (NADPH2)
keywords: MTHFR C677T; MTRR A66G; additive interaction; obesity; overweight; type 2 diabetes