title: [Preliminary evaluation of PET-CT and DWI for the detection of lymphoma bone marrow infiltration].
abstract: Objective:To evaluate the clinical value of PET-CT and DWI for the detection of bone marrow infiltration of lymphoma.Methods:The bone marrow samples of 93 untreated patients with pathologically diagnosed lymphoma were retrospectively analyzed. 61 patients underwent PET-CT examination, and other 32 underwent DWI examination. With bone marrow biopsy results as "gold standard" , the rates and sites of bone marrow infiltration of various lymphoma subtypes were analyzed, and the detection rates of the two imaging techniques were compared according to different lymphoma subtypes.Results:39 patients were diagnosed as bone marrow infiltration based on pathological examination of bone marrow biopsies from routine sampling sites and bone marrow pathological examination of biopsies guided by PET-CT and DWI. The sensitivity, specificity, accuracy, positive and negative predictive values of PET-CT for lymphoma bone marrow infiltration were 80.8%, 88.6%, 85.3%, 84.0% and 86.1%, respectively; for DWI examination, these rates were 84.6%, 89.5%, 87.5%, 84.6% and 89.5%, respectively. The detection rates of the two imaging techniques for aggressive lymphoma were 37.5% (18/48) and 38.1% (8/21), respectively, which were slightly higher than those for the indolent lymphoma [23.1% (3/13) and 27.3% (3/11)], although the differences were not statistically significant (P=0.521,P=0.660). For both aggressive lymphoma and indolent lymphoma, the detection rates of DWI were numerically slightly higher than those of PET-CT(P=0.963,P=1.000).Conclusions:PET-CT and DWI have important and similar diagnostic value for bone marrow infiltration of lymphoma. None of PET-CT and DWI can replace bone marrow biopsy (BMB). However, image-guided bone marrow biopsies can improve the detection rate of bone marrow infiltration of lymphoma.
authors.affiliation: Department of Hematology, Shanxi Medical University Affiliated Tumor Hospital, Taiyuan 030013, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Hematology, Shanxi Medical University Affiliated Tumor Hospital, Taiyuan 030013, China.
authors.forename: L P
authors.initials: LP
authors.lastname: Su
authors.affiliation: Department of Radiology, Shanxi Medical University Affiliated Tumor Hospital, Taiyuan 030013, China.
authors.forename: X T
authors.initials: XT
authors.lastname: Yang
authors.affiliation: Department of Radiology, Shanxi Medical University Affiliated Tumor Hospital, Taiyuan 030013, China.
authors.forename: J X
authors.initials: JX
authors.lastname: Zhang
authors.affiliation: Department of Radiology, Shanxi Medical University Affiliated Tumor Hospital, Taiyuan 030013, China.
authors.forename: M
authors.initials: M
authors.lastname: Zhao
authors.affiliation: Department of Hematology, Shanxi Medical University Affiliated Tumor Hospital, Taiyuan 030013, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Hematology, Shanxi Medical University Affiliated Tumor Hospital, Taiyuan 030013, China.
authors.forename: T
authors.initials: T
authors.lastname: Guan
authors.affiliation: Department of Hematology, Shanxi Medical University Affiliated Tumor Hospital, Taiyuan 030013, China.
authors.forename: X L
authors.initials: XL
authors.lastname: Liu
authors.affiliation: Department of Hematology, Shanxi Medical University Affiliated Tumor Hospital, Taiyuan 030013, China.
authors.forename: Y P
authors.initials: YP
authors.lastname: Zheng
authors.affiliation: Department of Hematology, Shanxi Medical University Affiliated Tumor Hospital, Taiyuan 030013, China.
authors.forename: W E
authors.initials: WE
authors.lastname: Han
mesh_terms: D000328:Adult; D001706:Biopsy; D001853:Bone Marrow / Q000000981:diagnostic imaging* / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D008223:Lymphoma / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D000072078:Positron Emission Tomography Computed Tomography / Q000706:statistics & numerical data; D012189:Retrospective Studies; D012680:Sensitivity and Specificity