title: Neural correlates of increased risk-taking propensity in sleep-deprived people along with a changing risk level.
abstract: Risky decision-making under a changing risk level is a complex process involving contextual information. The neural mechanism underlying how sleep deprivation (SD) influences risky decision-making behaviors with a changing risk level has yet to be elucidated. In this study, we used the Balloon Analogue Risk Task (BART) during functional magnetic resonance imaging to investigate the neural correlates of SD-induced changes on decision-making behaviors at different risk levels. Thirty-seven healthy male adults were recruited in this within-subjects, repeat-measure, counterbalanced study. These individuals were examined during a state of rested wakefulness state and after nearly 36 h of total SD. The results showed that SD increased the activation of risk modulation in the left inferior frontal gyrus and were positively correlated with risk-taking propensity after SD. Activation in the ventral striatum and thalamus during cash out was increased, and activation in the middle temporal gyrus after explosion (loss of money) was decreased in sleep-deprived subjects, providing additional evidence for greater risk-taking propensity after SD. These results extend our understanding of the neural mechanism underlying alteration of the risk-taking propensity in sleep-deprived individuals.
authors.affiliation: Beijing Institute of Basic Medical Sciences, 27 Taiping Road, Beijing, People's Republic of China.|Cognitive and Mental Health Research Center, Beijing, People's Republic of China.|Brain Science Center, Institute of Basic Medical Sciences, Beijing, People's Republic of China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Lei
authors.affiliation: Beijing Institute of Basic Medical Sciences, 27 Taiping Road, Beijing, People's Republic of China.|Cognitive and Mental Health Research Center, Beijing, People's Republic of China.
authors.forename: Lubin
authors.initials: L
authors.lastname: Wang
authors.affiliation: Beijing Institute of Basic Medical Sciences, 27 Taiping Road, Beijing, People's Republic of China.|Cognitive and Mental Health Research Center, Beijing, People's Republic of China.
authors.forename: Pinhong
authors.initials: P
authors.lastname: Chen
authors.affiliation: Beijing Institute of Basic Medical Sciences, 27 Taiping Road, Beijing, People's Republic of China.|Cognitive and Mental Health Research Center, Beijing, People's Republic of China.
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Radiology, PLA Army General Hospital, Beijing, People's Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: Han
authors.affiliation: Department of Radiology, PLA Army General Hospital, Beijing, People's Republic of China.
authors.forename: Mingmei
authors.initials: M
authors.lastname: Ge
authors.affiliation: Beijing Institute of Basic Medical Sciences, 27 Taiping Road, Beijing, People's Republic of China.|Cognitive and Mental Health Research Center, Beijing, People's Republic of China.
authors.forename: Liu
authors.initials: L
authors.lastname: Yang
authors.affiliation: Beijing Institute of Basic Medical Sciences, 27 Taiping Road, Beijing, People's Republic of China.|Cognitive and Mental Health Research Center, Beijing, People's Republic of China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Chen
authors.affiliation: School of Aerospace Medicine, Fourth Military Medical University, Xi'an, People's Republic of China. huwend@fmmu.edu.cn.
authors.forename: Wendong
authors.initials: W
authors.lastname: Hu
authors.affiliation: Department of Radiology, PLA Army General Hospital, Beijing, People's Republic of China. wuxinhuai_beijing@163.com.
authors.forename: Xinhuai
authors.initials: X
authors.lastname: Wu
authors.affiliation: Beijing Institute of Basic Medical Sciences, 27 Taiping Road, Beijing, People's Republic of China. yangz236@163.com.|Cognitive and Mental Health Research Center, Beijing, People's Republic of China. yangz236@163.com.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Yang
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001931:Brain Mapping; D003657:Decision Making / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D012146:Rest; D012309:Risk-Taking; D012892:Sleep Deprivation / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000523:psychology*; D014851:Wakefulness; D055815:Young Adult
keywords: BART; Inferior frontal cortex; Risky decision-making; Sleep deprivation; fMRI