title: Self-Assembly of Discrete RuII8Molecular Cages and Their in Vitro Anticancer Activity.
abstract: Four new octanuclear Ru(II) cages (OC-1-OC-4) were synthesized from dinuclear p-cymene ruthenium(II) acceptors [Ru2(μ-η4-C2O4)(CH3OH)2(η6-p-cymene)2](O3SCF3)2(A1), [Ru2(μ-η4-C6H2O4)(CH3OH)2(η6-p-cymene)2](O3SCF3)2(A2), [Ru2(dhnq)(H2O)2(η6-p-cymene)2](O3SCF3)2(A3), and [Ru2(dhtq)(H2O)2(η6-p-cymene)2](O3SCF3)2(A4) separately with a tetradentate pyridyl ligand (L1) in methanol using coordination-driven self-assembly [L1= N,N,N',N'-tetra(pyridin-4-yl)benzene-1,4-diamine]. The octanuclear cages are fully characterized by various spectroscopic techniques including single-crystal X-ray diffraction analysis of OC-4. The self-assembled cages show strong in vitro anticancer activity against human lung adenocarcinoma A549 and human cervical cancer HeLa cell lines as observed from the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Of all the octanuclear cages, OC-3 exhibits remarkable anticancer activity against both cancer cell lines and is more active than that reported for cisplatin. The excellent anticancer activity of OC-3 and OC-4 highlights the importance of the synergistic effects of the spacer component of the dinuclear p-cymene Ru(II) acceptor clips.
authors.affiliation: Department of Inorganic and Physical Chemistry and †Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science , Bangalore 560012, India.
authors.forename: Aderonke
authors.initials: A
authors.lastname: Ajibola Adeyemo
authors.affiliation: Department of Inorganic and Physical Chemistry and †Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science , Bangalore 560012, India.
authors.forename: Abhijith
authors.initials: A
authors.lastname: Shettar
authors.affiliation: Department of Inorganic and Physical Chemistry and †Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science , Bangalore 560012, India.
authors.forename: Imtiyaz Ahmad
authors.initials: IA
authors.lastname: Bhat
authors.affiliation: Department of Inorganic and Physical Chemistry and †Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science , Bangalore 560012, India.
authors.forename: Paturu
authors.initials: P
authors.lastname: Kondaiah
authors.affiliation: Department of Inorganic and Physical Chemistry and †Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science , Bangalore 560012, India.
authors.forename: Partha Sarathi
authors.identifier: http://orcid.org/0000-0001-6891-6697
authors.initials: PS
authors.lastname: Mukherjee
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D000081007:Cymenes; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D039821:Monoterpenes / Q000737:chemistry / Q000494:pharmacology*; D012428:Ruthenium / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D000081007:Cymenes; D039821:Monoterpenes; C007210:4-cymene; D012428:Ruthenium