title: Synthesis and biological properties of galactofuranosyl-containing fluorescent dyes.
abstract: Two fluorescent galactofuranosides were synthesized and their biological activities evaluated on non-infected and Leishmania infected macrophages. Both tagged scaffolds were able to penetrate macrophages. Compared to the activity of the parent octyl galactofuranoside used as a reference, the fluorescein-conjugate showed altered biological properties while the rhodamine 6G one synergistically acted with the lipid chain to significantly increase antiparasitic activity.
authors.affiliation: Ecole Nationale Supérieure de Chimie de Rennes, CNRS, UMR 6226, 11 Allée de Beaulieu, CS 50837, 35708 Rennes Cedex 7, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Legentil
authors.affiliation: INSERM U1085-IRSET (Institut de Recherche en Santé Environnement et Travail), Université Rennes 1, Rennes, France; Centre Hospitalier Universitaire de Rennes, Service de Parasitologie-Mycologie, Rennes, France.
authors.forename: Sorya
authors.initials: S
authors.lastname: Belaz
authors.affiliation: INSERM U1085-IRSET (Institut de Recherche en Santé Environnement et Travail), Université Rennes 1, Rennes, France; Centre Hospitalier Universitaire de Rennes, Service de Parasitologie-Mycologie, Rennes, France.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Gangneux
authors.affiliation: INSERM U1085-IRSET (Institut de Recherche en Santé Environnement et Travail), Université Rennes 1, Rennes, France; Centre Hospitalier Universitaire de Rennes, Service de Parasitologie-Mycologie, Rennes, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Robert-Gangneux
authors.affiliation: Ecole Nationale Supérieure de Chimie de Rennes, CNRS, UMR 6226, 11 Allée de Beaulieu, CS 50837, 35708 Rennes Cedex 7, France. Electronic address: vincent.ferrieres@ensc-rennes.fr.
authors.forename: Vincent
authors.initials: V
authors.lastname: Ferrières
mesh_terms: D000981:Antiprotozoal Agents / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D005452:Fluoresceins / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D005697:Galactosides / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D006801:Humans; D007893:Leishmania donovani / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects / Q000469:parasitology; D012235:Rhodamines / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity
chemical_list: C000622943:6-(rhodamineamino)-1-hexyl galactofuranoside; D000981:Antiprotozoal Agents; D005452:Fluoresceins; D005456:Fluorescent Dyes; D005697:Galactosides; D012235:Rhodamines
keywords: Carbohydrates; Fluorescence; Galactofuranosides; Leishmania; Macrophages