title: Development of magneto-plasmonic nanoparticles for multimodal image-guided therapy to the brain.
abstract: Magneto-plasmonic nanoparticles are one of the emerging multi-functional materials in the field of nanomedicine. Their potential for targeting and multi-modal imaging is highly attractive. In this study, magnetic core/gold shell (MNP@Au) magneto-plasmonic nanoparticles were synthesized by citrate reduction of Au ions on magnetic nanoparticle seeds. Hydrodynamic size and optical properties of magneto-plasmonic nanoparticles synthesized with the variation of Au ions and reducing agent concentrations were evaluated. The synthesized magneto-plasmonic nanoparticles exhibited superparamagnetic properties, and their magnetic properties contributed to the concentration-dependent contrast in magnetic resonance imaging (MRI). The imaging contrast from the gold shell part of the magneto-plasmonic nanoparticles was also confirmed by X-ray computed tomography (CT). The transmigration study of the magneto-plasmonic nanoparticles using an in vitro blood-brain barrier (BBB) model proved enhanced transmigration efficiency without disrupting the integrity of the BBB, and showed potential to be used for brain diseases and neurological disorders.
authors.affiliation: Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida 33199, USA. nairm@fiu.edu.
authors.forename: Asahi
authors.identifier: http://orcid.org/0000-0002-1234-6047
authors.initials: A
authors.lastname: Tomitaka
authors.affiliation: Molecular Imaging Program at Stanford (MIPS), The James H Clark Center, Stanford University, Stanford, California 94305, USA and Department of Radiology, Stanford University School of Medicine, Stanford, California 94305, USA.
authors.forename: Hamed
authors.initials: H
authors.lastname: Arami
authors.affiliation: Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida 33199, USA. nairm@fiu.edu.
authors.forename: Andrea
authors.initials: A
authors.lastname: Raymond
authors.affiliation: Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida 33199, USA. nairm@fiu.edu.
authors.forename: Adriana
authors.initials: A
authors.lastname: Yndart
authors.affiliation: Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida 33199, USA. nairm@fiu.edu.
authors.forename: Ajeet
authors.initials: A
authors.lastname: Kaushik
authors.affiliation: Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida 33199, USA. nairm@fiu.edu.
authors.forename: Rahul Dev
authors.initials: RD
authors.lastname: Jayant
authors.affiliation: Department of Electrical and Computer Engineering, Yokohama National University, Yokohama 240-8501, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Takemura
authors.affiliation: Department of Chemistry & Biochemistry, Southeast Environmental Research Center, Florida International University, Miami, Florida 33199, USA.
authors.forename: Yong
authors.initials: Y
authors.lastname: Cai
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, Miami, Florida 33136, USA.
authors.forename: Michal
authors.initials: M
authors.lastname: Toborek
authors.affiliation: Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida 33199, USA. nairm@fiu.edu and Department of Immunology, Institute of NeuroImmune Pharmacology, Centre for Personalized Nanomedicine, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida 33199, USA.
authors.forename: Madhavan
authors.initials: M
authors.lastname: Nair
mesh_terms: D001253:Astrocytes / Q000166:cytology; D001812:Blood-Brain Barrier; D001921:Brain / Q000166:cytology / Q000000981:diagnostic imaging*; D002478:Cells, Cultured; D042783:Endothelial Cells / Q000166:cytology; D006046:Gold; D006801:Humans; D008279:Magnetic Resonance Imaging; D008280:Magnetics; D058185:Magnetite Nanoparticles; D008954:Models, Biological; D064847:Multimodal Imaging
chemical_list: D058185:Magnetite Nanoparticles; D006046:Gold