title: Novel Therapy for the Treatment of Early-Onset Preeclampsia.
abstract: Preeclampsia is a multisystem disorder affecting 2% to 8% of pregnancies and a leading cause of maternal and perinatal morbidity and mortality worldwide. Recent investigations have improved our understanding of the pathogenesis of this potentially life-threatening disease, especially in its early-onset form of manifestation. Despite these advances, therapeutic options are still limited and no effective pharmacologic interventions are currently available. Ongoing lines of research indicate some potential novel treatments targeting specific pathogenic steps. In this article we provide an updated overview of the multiple therapeutic approaches under preclinical and clinical assessment for the treatment of early-onset preeclampsia.
authors.affiliation: *Department of Obstetrics and Gynecology, Foundation MBBM, University of Milano-Bicocca School of Medicine and Surgery, Monza, MB, Italy †Department of Obstetrics, Gynecology and Reproductive Sciences, Yale Women and Children's Center for Blood Disorders and Preeclampsia Advancement, Yale University School of Medicine, New Haven, Connecticut.
authors.forename: Sara
authors.initials: S
authors.lastname: Ornaghi
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Paidas
mesh_terms: D015195:Drug Design; D005260:Female; D006801:Humans; D008428:Maternal Mortality; D011225:Pre-Eclampsia / Q000188:drug therapy* / Q000503:physiopathology; D011247:Pregnancy