title: Thromboembolic events in patients with inflammatory bowel disease.
abstract: OBJECTIVE
  Inflammatory bowel disease (ulcerative colitis and Crohn's disease) is characterized by a chronic inflammatory condition, and is accompanied by abnormalities in coagulation and a hyper-coagulable state. This study was conducted to examine the risk factors for developing Thromboembolic Events in Inflammatory Bowel Disease (IBD) in a population with prevalent consanguinity.
  
  
  METHODS
  Patients with a definitive diagnosis of IBD who were seen in the gastroenterology clinic of King Khalid University Hospital (Riyadh, Saudi Arabia) from 2010- to 2012, were asked to participate in this prospective cohort study, and were followed for one 1 year. Data was collected using specifically designed case report forms (CRF) by trained research personnel.
  
  
  RESULTS
  A total of 100 Saudi patients with IBD were studied. There were 51 (51%) women and the mean ± standard deviation (SD) age of the group was 31.24 ± 10.78 years. Those with Crohn's disease constituted 72% of the patients, and 28% had ulcerative colitis. Eight patients (8%) had at least one Thrombotic Event ([six deep venous thrombosis (DVT), and two pulmonary embolism (PE)]. Family history of deep venous thrombosis was present in 5%, and family history of pulmonary embolism (PE) in 4% of the patients. After adjusting for age and gender, a family history of Thrombotic event was identified as to be the only statistically significant predictor of thrombosis in IBD patients (RR = 9.22, 95% CI: 2.10--40.43).
  
  
  CONCLUSIONS
  In a population with high consanguinity, Thromboembolic events (DVT and PE) had a prevalence of 8% among IBD patients, positive family history of pulmonary embolism was a predictor of thrombosis. Further studies are needed to explore the role of genetic factors in this population.
authors.affiliation: Department of Medicine, Division of Hematology/Oncology, King Saud University College of Medicine and King Khalid University Hospital, Riyadh, Saudi Arabia.
authors.forename: Farjah H
authors.initials: FH
authors.lastname: Algahtani
authors.affiliation: Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: Youssef M K
authors.initials: YM
authors.lastname: Farag
authors.affiliation: Gastroenterology Division, King Saud University College of Medicine, Riyadh, Saudi Arabia.
authors.forename: Abdulrahman M
authors.initials: AM
authors.lastname: Aljebreen
authors.affiliation: Gastroenterology Division, King Saud University College of Medicine, Riyadh, Saudi Arabia.
authors.forename: Nahla A
authors.initials: NA
authors.lastname: Alazzam
authors.affiliation: Department of Medicine, Division of Hematology/Oncology, King Saud University College of Medicine and King Khalid University Hospital, Riyadh, Saudi Arabia.
authors.forename: Aamer S
authors.initials: AS
authors.lastname: Aleem
authors.affiliation: AlFaisal University College of Medicine, Riyadh, Saudi Arabia.
authors.forename: Fouad F
authors.initials: FF
authors.lastname: Jabri
authors.affiliation: AlFaisal University College of Medicine, Riyadh, Saudi Arabia.
authors.forename: Mohammad H
authors.initials: MH
authors.lastname: Rajab
authors.affiliation: AlFaisal University College of Medicine, Riyadh, Saudi Arabia.
authors.forename: Mohamed M
authors.initials: MM
authors.lastname: Shoukri
mesh_terms: D000328:Adult; D003241:Consanguinity; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications*; D008297:Male; D015995:Prevalence; D011446:Prospective Studies; D011655:Pulmonary Embolism / Q000453:epidemiology* / Q000209:etiology; D012307:Risk Factors; D012529:Saudi Arabia / Q000453:epidemiology; D020246:Venous Thrombosis / Q000453:epidemiology* / Q000209:etiology; D055815:Young Adult