title: The potential role of oxytocin and perinatal factors in the pathogenesis of autism spectrum disorders - review of the literature.
abstract: Autism Spectrum Disorders (ASD) are characterized by: social and communication impairments, and by restricted repetitive behaviors. The aim of the present paper is to review abnormalities of oxytocin (OXT) and related congenital malformations in ASD. A literature search was conducted in the PubMed database up to 2016 for articles related to the pathomechanism of ASD, abnormalities of OXT and the OXT polymorphism in ASD. The pathomechanism of ASD has yet to be. The development of ASD is suggested to be related to abnormalities of the oxytocin-arginin-vasopressin system. Previous results suggest that OXT and arginine vasopressin (AVP) may play a role in the etiopathogenesis of ASD.
authors.affiliation: Department of Obstetrics and Gynaecology, Albert Szent-Gyorgyi Clinical Centre, University of Szeged, Szeged, Hungary; KF TFK Health Research and Health Promotion Research Group, Kecskemet, Hungary. Electronic address: vmelinda74@gmail.com.
authors.forename: Melinda
authors.initials: M
authors.lastname: Vanya
authors.affiliation: Division of Adolescent Psychiatry, Department of Paediatrics, Albert Szent-Gyorgyi Clinical Centre, University of Szeged, Szeged, Hungary.
authors.forename: Szabina
authors.initials: S
authors.lastname: Szucs
authors.affiliation: Division of Adolescent Psychiatry, Department of Paediatrics, Albert Szent-Gyorgyi Clinical Centre, University of Szeged, Szeged, Hungary.
authors.forename: Agnes
authors.initials: A
authors.lastname: Vetro
authors.affiliation: Department of Obstetrics and Gynaecology, Albert Szent-Gyorgyi Clinical Centre, University of Szeged, Szeged, Hungary.
authors.forename: Gyorgy
authors.initials: G
authors.lastname: Bartfai
mesh_terms: D000067877:Autism Spectrum Disorder / Q000209:etiology* / Q000235:genetics; D005260:Female; D005492:Folic Acid / Q000009:adverse effects; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D008297:Male; D009481:Neurophysins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D047928:Premature Birth / Q000523:psychology*; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced / Q000523:psychology*; D011498:Protein Precursors / Q000235:genetics*; D018045:Receptors, Oxytocin / Q000235:genetics*; D014667:Vasopressins / Q000235:genetics*
chemical_list: C438657:AVP protein, human; D009481:Neurophysins; C569600:OXTR protein, human; D011498:Protein Precursors; D018045:Receptors, Oxytocin; D014667:Vasopressins; D005492:Folic Acid
keywords: Autism spectrum disorder, behavior; Cesarean section, oxytocin, oxytocin-receptor polymorphism; Gene