title: Transcatheter edge-to-edge mitral valve repair in heart failure.
abstract: Heart failure and severe mitral regurgitation (MR) are mutually dependent. Secondary MR is a consequence of chronic heart failure in patients with severely depressed left ventricular ejection fraction (LV-EF) and LV dilatation. Severe MR in heart failure patients worsens prognosis and accelerates LV dilatation and decline in LV-EF. Interventional therapies have changed clinical practice for heart failure patients with secondary MR. In this review we summarize the available data of patients with chronic heart failure undergoing transcatheter edge-to-edge mitral valve repair (TMVR) with the MitraClip® system for severe secondary mitral regurgitation. TMVR could be a therapeutic option with a favorable long-term outcome even in patients with severely depressed LV-EF. Selection criteria predicting mortality in patients undergoing TMVR comprise clinical, laboratory and echocardiographic parameters and can help for clinical decision-making. Ongoing randomized trials will influence the use of interventional treatment of MR in these high-risk patients.
authors.affiliation: Medizinische Klinik und Poliklinik I, Ludwig-Maximilians-Universität München, Munich, Germany - morban@med.lmu.de.
authors.forename: Mathias
authors.initials: M
authors.lastname: Orban
authors.affiliation: Medizinische Klinik und Poliklinik I, Ludwig-Maximilians-Universität München, Munich, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Orban
authors.affiliation: Medizinische Klinik und Poliklinik I, Ludwig-Maximilians-Universität München, Munich, Germany.
authors.forename: Daniel
authors.initials: D
authors.lastname: Braun
authors.affiliation: Medizinische Klinik und Poliklinik I, Ludwig-Maximilians-Universität München, Munich, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Nabauer
authors.affiliation: Medizinische Klinik und Poliklinik I, Ludwig-Maximilians-Universität München, Munich, Germany.|DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.
authors.forename: Steffen
authors.initials: S
authors.lastname: Massberg
authors.affiliation: Medizinische Klinik und Poliklinik I, Ludwig-Maximilians-Universität München, Munich, Germany.
authors.forename: Jörg
authors.initials: J
authors.lastname: Hausleiter
mesh_terms: D006328:Cardiac Catheterization / Q000379:methods; D002908:Chronic Disease; D004452:Echocardiography / Q000379:methods; D006333:Heart Failure / Q000150:complications / Q000601:surgery*; D006801:Humans; D008943:Mitral Valve / Q000473:pathology / Q000601:surgery*; D008944:Mitral Valve Insufficiency / Q000209:etiology / Q000601:surgery*; D018579:Patient Selection; D011379:Prognosis; D013318:Stroke Volume; D018487:Ventricular Dysfunction, Left / Q000209:etiology