title: High-Throughput Synthetic Chemistry Enabled by Organic Solvent Disintegrating Tablet.
abstract: Synthetic chemistry remains a time- and labor-intensive process of inherent hazardous nature. Our organic solvent disintegrating tablet (O-Tab) technology has shown potential to make industrial/synthetic chemistry more efficient. As is the case with pharmaceutical tablets, our reagent-containing O-Tabs are mechanically strong, but disintegrate rapidly when in contact with reaction media (organic solvents). For O-Tabs containing sensitive chemicals, they can be further coated to insulate them from air and moisture.
authors.affiliation: College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 2999 North Renmin Lu, Shanghai, 201620, China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Li
authors.affiliation: College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 2999 North Renmin Lu, Shanghai, 201620, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Xu
authors.affiliation: College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 2999 North Renmin Lu, Shanghai, 201620, China.
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Xing
authors.affiliation: College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 2999 North Renmin Lu, Shanghai, 201620, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Xu
keywords: industrial chemistry; organic solvent disintegrating tablet; pharmaceutical formulation; synthesis design; tablets