title: One-Pot Three-Component Synthesis of Enamine-Functionalized 1,2,3-Triazoles via Cu-Catalytic Azide-Alkyne Click (CuAAC) and Cu-Catalyzed Vinyl Nitrene Transfer Sequence.
abstract: A number of enamine-functionalized 1,2,3-triazole derivatives have been prepared via the Cu-catalyzed three-component reaction of terminal alkyne, azide, and 2H-azirine. The reaction proceeds through insertion of vinyl nitrene into the C-Cu bond of the triazolyl-Cu species, providing an efficient and step- and atom-economic approach to the enamine-bearing polysubstituted 1,2,3-triazoles. The resulting triazoles were easily transformed to trisubstituted pyrazoles in the presence of a Rh catalyst.
authors.affiliation: Department of Chemistry, Zhejiang University , Hangzhou 310013, China.|College of Pharmaceutical Science, Zhejiang University of Technology , Hangzhou 310014, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhou
authors.affiliation: Department of Chemistry, Zhejiang University , Hangzhou 310013, China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Chemistry, Zhejiang University , Hangzhou 310013, China.
authors.forename: Hanhui
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Chemistry, Zhejiang University , Hangzhou 310013, China.
authors.forename: Wanzhi
authors.identifier: 0000-0002-7076-1521
authors.initials: W
authors.lastname: Chen