title: Exploiting Old Pathogens to Create New Therapeutics.
abstract: Intestinal worms are well known for their potent immuno-modulatory capacity. In a recent study, Navarro et al. (2016) identify a secreted hookworm protein that can suppress allergic responses in both mice and humans. This represents an exciting strategy for treating chronic inflammatory disorders such as allergy.
authors.affiliation: Global Health Institute, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Vaud, Switzerland.
authors.forename: Tiffany
authors.initials: T
authors.lastname: Bouchery
authors.affiliation: Global Health Institute, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Vaud, Switzerland. Electronic address: nicola.harris@epfl.ch.
authors.forename: Nicola L
authors.initials: NL
authors.lastname: Harris
mesh_terms: D000723:Ancylostomatoidea / Q000276:immunology* / Q000472:pathogenicity; D000818:Animals; D015703:Antigens, CD; D001249:Asthma / Q000628:therapy; D015551:Autoimmunity / Q000276:immunology; D002908:Chronic Disease; D003713:Dendritic Cells / Q000276:immunology; D006373:Helminthiasis / Q000276:immunology; D006725:Hookworm Infections / Q000276:immunology* / Q000469:parasitology / Q000628:therapy*; D006790:Host-Parasite Interactions / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology* / Q000628:therapy*; D056724:Immunity, Humoral; D007113:Immunity, Innate; D056747:Immunomodulation / Q000276:immunology; D039001:Integrin alpha Chains; D007411:Intestinal Diseases, Parasitic / Q000276:immunology; D008168:Lung / Q000276:immunology; D008198:Lymph Nodes / Q000276:immunology; D051379:Mice; D011506:Proteins / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
chemical_list: D015703:Antigens, CD; D039001:Integrin alpha Chains; D011506:Proteins; C091367:alpha E integrins
keywords: allergy; asthma; dendritic cells; helminth; immunomodulation; protein therapeutics; regulatory T cells