title: Photoactive platinum diimine complexes showing induced cancer cell death by apoptosis.
abstract: Photoinduced cytotoxicity mediated by a triphenylenamine-modified platinum diimine complex in human breast adenocarcinoma cells has been studied by cell viability assay. The triphenylenamine-modified platinum diimine complex showed more potent cytotoxicity in light than its carboxylate-modified analogue. To gain insights into the mechanism of photodynamic activity of this class of platinum diimine complexes, flow cytometric analyses were performed. The results suggest that upon irradiation the two platinum diimine complexes studied could induce cell cycle arrest in G2/M or S phase, and both of them could induce cancer cell death by apoptosis.
authors.affiliation: Chemical Biology and Molecular Engineering Laboratory of Education Ministry, Institute of Molecular Science, Shanxi University, Taiyuan, Shanxi, 030006, China. zgzhang@sxu.edu.cn.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Chemical Biology and Molecular Engineering Laboratory of Education Ministry, Institute of Molecular Science, Shanxi University, Taiyuan, Shanxi, 030006, China.
authors.forename: Ruihui
authors.initials: R
authors.lastname: Dai
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D056831:Coordination Complexes / Q000008:administration & dosage / Q000737:chemistry; D006801:Humans; D008027:Light; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D017319:Photosensitizing Agents / Q000008:administration & dosage / Q000737:chemistry; D010984:Platinum / Q000008:administration & dosage* / Q000737:chemistry; D017671:Platinum Compounds / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D056831:Coordination Complexes; D017319:Photosensitizing Agents; D017671:Platinum Compounds; D010984:Platinum
keywords: Apoptosis; Cell cycle arrest; Cytotoxicity; Photodynamic therapy; Platinum diimine complex