title: Parasites Dampen Dendritic Cell Activation to Ensure Their Survival.
abstract: Dendritic cells (DCs) are critical for induction of protective immunity against Leishmania major. However, DC activation occurs only several weeks after parasite transmission. Parasites synthesize a macrophage-inducible C-type lectin (Mincle) ligand. Engagement of Mincle by the parasite ligand dampens DC activation, thus delaying induction of interferon-γ-producing T cells responsible for parasite eradication.
authors.affiliation: Department of Dermatology, University Medical Center, Johannes Gutenberg-University Mainz, Germany. Electronic address: vonstebu@uni-mainz.de.
authors.forename: Esther
authors.initials: E
authors.lastname: von Stebut
mesh_terms: D003713:Dendritic Cells / Q000276:immunology*; D037181:Lectins, C-Type / Q000378:metabolism; D007891:Leishmania / Q000276:immunology / Q000502:physiology*; D007896:Leishmaniasis / Q000276:immunology* / Q000469:parasitology* / Q000635:transmission; D008024:Ligands; D013601:T-Lymphocytes / Q000276:immunology / Q000469:parasitology
chemical_list: D037181:Lectins, C-Type; D008024:Ligands