title: The impact of calcineurin inhibitors and mammalian target of rapamycininhibitors on anxiety and depression scores in kidney transplant patients.
abstract: OBJECTIVE
  Depression and anxiety are prevalent symptoms in kidney transplant patients. We aimed to evaluate the frequency and the severity of depression and anxiety symptoms in kidney transplant recipients using the Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI). The data were compared between the patients on CNI-based and mTORi-based maintenance immunosuppressive regimens.
  
  
  METHODS
  A total of 94 kidney transplant patients were enrolled in the study after exclusion of the patients already taking neuropsychiatric medications or unwilling to participate in the study. Participants were asked to self-report the inventories.
  
  
  RESULTS
  Analysis of data showed that 62 (66%) recipients had BDI scores that indicated depression. The patients on CNI-based regimens (n = 74) had increased total BDI scores compared those on mTORi-based regimens [18 (8.75-28) vs. 6 (5.25-14.25), respectively, P < 0.001]. Regarding BAI scores, 79 patients (84%) had prominent anxiety symptoms. The patients on CNI-based regimens had significantly increased total BAI scores compared to those on mTORi-based regimens [21 (13-30.50) vs. 10.50 (8.25-14.75), respectively, P < 0.001].
  
  
  CONCLUSIONS
  Our results identified fewer side effects of mTORi-based maintenance immunosuppressive regimens regarding depression and anxiety symptoms compared to CNI-based regimens in kidney transplant patients.
authors.affiliation: Department of Nephrology, Dışkapı Yıldırım Beyazıt Education and Research Hospital, Ankara, Turkey.
authors.forename: Ebru
authors.initials: E
authors.lastname: Gök Oğuz
authors.affiliation: Department of Nephrology, Dışkapı Yıldırım Beyazıt Education and Research Hospital, Ankara, Turkey.
authors.forename: Gülay
authors.initials: G
authors.lastname: Ulusal Okyay
authors.affiliation: Department of Nephrology, Dışkapı Yıldırım Beyazıt Education and Research Hospital, Ankara, Turkey.
authors.forename: Güner
authors.initials: G
authors.lastname: Karaveli Gürsoy
authors.affiliation: Department of Nephrology, Dışkapı Yıldırım Beyazıt Education and Research Hospital, Ankara, Turkey.
authors.forename: Zafer
authors.initials: Z
authors.lastname: Ercan
authors.affiliation: Department of Nephrology, Dışkapı Yıldırım Beyazıt Education and Research Hospital, Ankara, Turkey.
authors.forename: Özgür
authors.initials: Ö
authors.lastname: Merhametsiz
authors.affiliation: Department of Nephrology, Dışkapı Yıldırım Beyazıt Education and Research Hospital, Ankara, Turkey.
authors.forename: Başol
authors.initials: B
authors.lastname: Canbakan
authors.affiliation: Department of Nephrology, Dışkapı Yıldırım Beyazıt Education and Research Hospital, Ankara, Turkey.
authors.forename: Mehmet Deniz
authors.initials: MD
authors.lastname: Aylı
mesh_terms: D001007:Anxiety; D065095:Calcineurin Inhibitors; D003863:Depression; D006801:Humans; D007166:Immunosuppressive Agents; D016030:Kidney Transplantation; D058570:TOR Serine-Threonine Kinases
chemical_list: D065095:Calcineurin Inhibitors; D007166:Immunosuppressive Agents; D058570:TOR Serine-Threonine Kinases
keywords: Anxiety; calcineurin inhibitors; depression; kidney transplantation; mammalian target of rapamycin inhibitors