title: Type 2 diabetes mellitus is associated with increased risks of sarcopenia and pre-sarcopenia in Chinese elderly.
abstract: Sarcopenia is a condition characterized by progressive and generalized loss of skeletal muscle mass and function. In this study, we used a cross-sectional study with 1090 community-dwelling Chinese citizens aged 60 years and older to evaluate the association of type 2 diabetes mellitus (T2DM) with the risk of sarcopenia and pre-sarcopenia. Sarcopenia was defined using the Asian Working Group for Sarcopenia (AWGS) criteria that include both muscle mass and muscle function/physical activity. Pre-sarcopenia was defined as having low skeletal muscle index but with normal muscle/physical activity. The prevalence of sarcopenia and pre-sarcopenia was significantly higher in T2DM patients than in healthy controls (14.8% vs. 11.2%, p = 0.035 for sarcopenia, and 14.4% vs. 8.4%, p = 0.002 for pre-sarcopenia). In multivariate logistic regression analyses adjusting by age, gender, anti-diabetic medication, energy intake, protein intake, physical activity, and visceral fat area, we found that Chinese elderly with T2DM exhibited significantly increased risks of sarcopenia (OR = 1.37, 95% CI = 1.02-2.03) and pre-sarcopenia (OR = 1.73, 95% CI = 1.10-2.83) compared to non-diabetic individuals. This is the first study to evaluate the association of T2DM with the risks of sarcopenia and pre-sarcopenia in China. Among a group of community-dwelling Chinese elderly, T2DM was significantly associated with increased risks of sarcopenia and pre-sarcopenia.
authors.affiliation: Department of Endocrinology and Clinical Nutrition, The Affiliated Hospital of Jiangsu University, Zhenjiang, China.
authors.forename: Taotao
authors.initials: T
authors.lastname: Wang
authors.affiliation: Department of Endocrinology and Clinical Nutrition, The Affiliated Hospital of Jiangsu University, Zhenjiang, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Feng
authors.affiliation: Department of Endocrinology and Clinical Nutrition, The Affiliated Hospital of Jiangsu University, Zhenjiang, China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Department of Endocrinology and Clinical Nutrition, The Affiliated Hospital of Jiangsu University, Zhenjiang, China.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Gong
authors.affiliation: Department of Endocrinology and Clinical Nutrition, The Affiliated Hospital of Jiangsu University, Zhenjiang, China.
authors.forename: Song
authors.initials: S
authors.lastname: Xia
authors.affiliation: Jiangsu University Library, Zhenjiang, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Wei
authors.affiliation: Department of Endocrinology and Clinical Nutrition, The Affiliated Hospital of Jiangsu University, Zhenjiang, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Hu
authors.affiliation: Department of Endocrinology and Clinical Nutrition, The Affiliated Hospital of Jiangsu University, Zhenjiang, China.
authors.forename: Ran
authors.initials: R
authors.lastname: Tao
authors.affiliation: Department of Endocrinology and Clinical Nutrition, The Affiliated Hospital of Jiangsu University, Zhenjiang, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Li
authors.affiliation: Pritzker School of Medicine, University of Chicago, USA.
authors.forename: Frank
authors.initials: F
authors.lastname: Qian
authors.affiliation: Department of Endocrinology and Clinical Nutrition, The Affiliated Hospital of Jiangsu University, Zhenjiang, China.
authors.forename: Li
authors.initials: L
authors.lastname: Yu
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D002681:China / Q000453:epidemiology; D048909:Diabetes Complications / Q000453:epidemiology*; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D055948:Sarcopenia / Q000453:epidemiology* / Q000209:etiology