title: PNIPAM grafted surfaces through ATRP and RAFT polymerization: Chemistry and bioadhesion.
abstract: Biomaterials surface design is critical for the control of materials and biological system interactions. Being regulated by a layer of molecular dimensions, bioadhesion could be effectively tailored by polymer surface grafting. Basically, this surface modification can be controlled by radical polymerization, which is a useful tool for this purpose. The aim of this review is to provide a comprehensive overview of the role of surface characteristics on bioadhesion properties. We place a particular focus on biomaterials functionalized with a brush surface, on presentation of grafting techniques for "grafting to" and "grafting from" strategies and on brush characterization methods. Since atom transfer radical polymerization (ATRP) and reversible addition-fragmentation chain transfer (RAFT) polymerization are the most frequently used grafting techniques, their main characteristics will be explained. Through the example of poly(N-isopropylacrylamide) (PNIPAM) which is a widely used polymer allowing tuneable cell adhesion, smart surfaces involving PNIPAM will be presented with their main modern applications.
authors.affiliation: CIRIMAT, University of Toulouse, CNRS, INPT, UPS, Université Paul Sabatier, Faculté de Pharmacie, 35 Chemin des Maraichers, 31062 Toulouse cedex 9, France.
authors.forename: G
authors.initials: G
authors.lastname: Conzatti
authors.affiliation: CIRIMAT, University of Toulouse, CNRS, INPT, UPS, Université Paul Sabatier, Faculté de Pharmacie, 35 Chemin des Maraichers, 31062 Toulouse cedex 9, France.
authors.forename: S
authors.initials: S
authors.lastname: Cavalie
authors.affiliation: CIRIMAT, Université de Toulouse, CNRS, INPT, UPS, ENSIACET, 4 allée Emile Monso, CS 44362, 31030 Toulouse cedex 4, France.
authors.forename: C
authors.initials: C
authors.lastname: Combes
authors.affiliation: Université Fédérale Midi-Pyrénées, Université de Toulouse III Paul Sabatier, Inserm U1037, CRCT de Toulouse, 2 avenue Hubert Curien CS 53717 31037 Toulouse Cedex 1, France.
authors.forename: J
authors.initials: J
authors.lastname: Torrisani
authors.affiliation: Université Fédérale Midi-Pyrénées, Université de Toulouse III Paul Sabatier, Inserm U1037, CRCT de Toulouse, 2 avenue Hubert Curien CS 53717 31037 Toulouse Cedex 1, France; Gastrointestinal Surgery Department, Purpan Hospital - CHU de Toulouse, Place du Dr Baylac, 31059 Toulouse, France.
authors.forename: N
authors.initials: N
authors.lastname: Carrere
authors.affiliation: CIRIMAT, University of Toulouse, CNRS, INPT, UPS, Université Paul Sabatier, Faculté de Pharmacie, 35 Chemin des Maraichers, 31062 Toulouse cedex 9, France. Electronic address: audrey.tourrette@univ-tlse3.fr.
authors.forename: A
authors.initials: A
authors.lastname: Tourrette
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000327:Adsorption; D001672:Biocompatible Materials / Q000737:chemistry*; D002448:Cell Adhesion; D006801:Humans; D007700:Kinetics; D008855:Microscopy, Electron, Scanning; D058105:Polymerization; D011108:Polymers / Q000737:chemistry; D013499:Surface Properties; D013696:Temperature; D023822:Tissue Engineering / Q000379:methods
chemical_list: D000180:Acrylic Resins; D001672:Biocompatible Materials; D011108:Polymers; C052970:poly-N-isopropylacrylamide
keywords: Atom transfer radical polymerization; Bioadhesion; Poly(N-isopropylacrylamide); Reversible addition fragmentation chain transfer polymerization; Surface functionalization