title: Quantitative analysis of tumor-associated tissue eosinophilia in different histological grades of oral squamous cell carcinoma.
abstract: OBJECTIVE
  Oral squamous cell carcinoma (OSCC) is the 8 th most common aggressive epithelial malignant neoplasm worldwide today. The eosinophil may be a "multifaceted cell" that can be associated with wound-healing processes, as well as to tissue damage which has increased the speculations around tumor-associated tissue eosinophilia in malignant tumors. The aim of this study was to detect the role and quantitative analysis of tumor-associated tissue eosinophils in different histological grades of OSCC.
  
  
  METHODS
  A retrospective study was carried out in sixty cases of histopathologically graded OSCCs. Tissue sections of 4 μ thickness were made from paraffin-embedded tissue blocks and were stained with hematoxylin and eosin. Eosinophils were counted under randomly selected twenty high-power (×40) fields. Data were subjected to statistical analysis using ANOVA test.
  
  
  RESULTS
  Higher mean eosinophils were recorded in well-differentiated squamous cell carcinoma (WDSCC) followed by moderately differentiated squamous cell carcinoma (MDSCC) and poorly differentiated squamous cell carcinoma (PDSCC) groups, respectively. The difference in mean eosinophils was found to be statistically significant between WDSCC and MDSCC (P < 0.001), as well as between WDSCC and PDSCC (P < 0.001).
  
  
  CONCLUSIONS
  Tumor-associated tissue eosinophil count is higher in WDSCC as compared to moderate and PDSCC.
authors.affiliation: Department of Service Clinic, Government Dental College and Research Institute, Bengaluru, Karnataka, India.
authors.forename: Rashmi
authors.initials: R
authors.lastname: Bankur
authors.affiliation: Department of Oral and Maxillofacial Pathology, MR Ambedkar Dental College, Bengaluru, Karnataka, India.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Rodrigues
authors.affiliation: ECHS Polyclinic, Changanassery, Kerala, India.
authors.forename: D
authors.initials: D
authors.lastname: Anjaly
authors.affiliation: Department of Oral and Maxillofacial Pathology, Sri Sankara Dental College, Akathumuri, Kerala, India.
authors.forename: Pillai Arun
authors.initials: PA
authors.lastname: Gopinathan
authors.affiliation: Department of Periodontology and Implantology, Guru Gobind Singh Institute of Dental Sciences, Burhanpur, Madhya Pradesh, India.
authors.forename: Praveen Kumar
authors.initials: PK
authors.lastname: Bankur
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000145:classification / Q000473:pathology*; D004802:Eosinophilia / Q000473:pathology*; D004804:Eosinophils / Q000473:pathology; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000145:classification / Q000473:pathology*; D060787:Neoplasm Grading / Q000379:methods; D016612:Paraffin Embedding; D012189:Retrospective Studies