title: Complementary pharmacological and toxicological characterization data on the pharmacological profile ofN-(2,6-dichlorophenyl)-2-(4-methyl-1-piperidinyl) acetamide.
abstract: This text presents complementary data corresponding to pharmacological and toxicological characterization ofN-(2,6-dichlorophenyl)-2-(4-methyl-1-piperidinyl)acetamide (LIA) compound. These data support our research article entitled "Pharmacological profile ofN-(2,6-dichlorophenyl)-2-(4-methyl-1-piperidinyl)acetamide, a novel analog of lidocaine" Déciga-Campos M., Navarrete-Vázquez G., López-Muñoz F.J., Librowski T., Sánchez-Recillas A., Yañez-Pérez V., Ortiz-Andrade R. (2016) [1]. Toxicity was predicted through the ACD/ToxSuite software and evaluatedin vivousing brine shrimp larvae (Artemia salinaL.) and mice. Also, we used the micronucleus assay to determine genotoxicity. We used the platform admetSAR to predict absorption properties of LIA and lidocaine.
authors.affiliation: Sección de Estudios de Posgrado e Investigación de la Escuela Superior de Medicina, Instituto Politécnico Nacional, Ciudad de México, México.
authors.forename: Myrna
authors.initials: M
authors.lastname: Déciga-Campos
authors.affiliation: Facultad de Farmacia de la Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos, México.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Navarrete-Vázquez
authors.affiliation: Departamento de Farmacobiología, Cinvestav, Sede Sur, Ciudad de México, México.
authors.forename: Francisco Javier
authors.initials: FJ
authors.lastname: López-Muñoz
authors.affiliation: Departament of Pharmacodynamics, Medical College, Jagiellonian University, Medyczna 9, 30-688 Kraków, Poland.
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Librowski
authors.affiliation: Laboratorio de Farmacología, Facultad de Química, Universidad Autónoma de Mérida, Yucatán, México.
authors.forename: Amanda
authors.initials: A
authors.lastname: Sánchez-Recillas
authors.affiliation: Laboratorio de Farmacología, Facultad de Química, Universidad Autónoma de Mérida, Yucatán, México.
authors.forename: Victor
authors.initials: V
authors.lastname: Yañez-Pérez
authors.affiliation: Laboratorio de Farmacología, Facultad de Química, Universidad Autónoma de Mérida, Yucatán, México.
authors.forename: Rolffy
authors.initials: R
authors.lastname: Ortiz-Andrade
keywords: CYP-P450, cytochrome P-450; DBP, diastolic blood pressure; HR, heart rate; IC50, half maximal inhibitory concentration; LC50, half lethal concentration; LD50, half lethal dose; LIA, N-(2,6-dichlorophenyl)-2-(4-methyl-1-piperidinyl)acetamide; Lidocaine; MNPCE, micronucleated polychromatic erythrocytes; N-(2,6-dichlorophenyl)-2-(4-methyl-1-piperidinyl)acetamide; NCE, normochromatic erythrocytes; PCE, polychromatic erythrocytes; SBP, systolic blood pressure; Toxicity