title: Exploiting Polydopamine Nanospheres to DNA Computing: A Simple, Enzyme-Free and G-Quadruplex-Free DNA Parity Generator/Checker for Error Detection during Data Transmission.
abstract: Molecular logic devices with various functions play an indispensable role in molecular data transmission/processing. However, during any kinds of data transmission, a constant and unavoidable circumstance is the appearance of bit errors, which have serious effects on the regular logic computation. Fortunately, these errors can be detected via plugging a parity generator (pG) at the transmitting terminal and a parity checker (pC) at the receiving terminal. Herein, taking advantage of the efficient adsorption/quenching ability of polydopamine nanospheres toward fluorophore-labeled single-stranded DNA, we explored this biocompatible nanomaterial to DNA logic computation and constructed the first simple, enzyme-free, and G-quadruplex-free DNA pG/pC for error detection through data transmission. Besides, graphene oxide (GO) was innovatively introduced as the "corrective element" to perform the output-correction function of pC. All the erroneous outputs were corrected to normal conditions completely, ensuring the regular operation of later logic computing. The total operation of this non-G4 pG/pC system (error checking/output-correction) could be completed within 1 h (about1/3of previous G4 platform) in a simpler and more efficient way. Notably, the odd pG/pC with analogous functions was also achieved through negative logic conversion to the fabricated even one. Furthermore, the same system could also perform three-input concatenated logic computation (XOR-INHIBIT), enriching the complexity of PDs-based logic computation.
authors.affiliation: State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun, Jilin 130022, China.|University of Chinese Academy of Sciences , Beijing 100039, China.
authors.forename: Daoqing
authors.initials: D
authors.lastname: Fan
authors.affiliation: State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun, Jilin 130022, China.|University of Chinese Academy of Sciences , Beijing 100039, China.
authors.forename: Erkang
authors.identifier: http://orcid.org/0000-0001-9843-1834
authors.initials: E
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun, Jilin 130022, China.|University of Chinese Academy of Sciences , Beijing 100039, China.
authors.forename: Shaojun
authors.identifier: http://orcid.org/0000-0003-3197-7204
authors.initials: S
authors.lastname: Dong
mesh_terms: D004247:DNA; D054856:G-Quadruplexes; D007211:Indoles; D054118:Nanospheres; D011108:Polymers
chemical_list: D007211:Indoles; D011108:Polymers; C568283:polydopamine; D004247:DNA
keywords: DNA parity generator/checker; G-quadruplex-free; enzyme-free; output-correction function; polydopamine nanosphere