title: Lipasin/betatrophin is differentially expressed in liver and white adipose tissue without association with insulin resistance in Wistar and Goto-Kakizaki rats.
abstract: Lipasin is a recently identified lipokine expressed predominantly in liver and in adipose tissue. It was linked to insulin resistance in mice and to type 1 and type 2 diabetes (T1D, T2D) in humans. No metabolic studies concerning lipasin were performed yet in rats. Therefore, we used rat model of T2D and insulin resistance, Goto-Kakizaki (GK) rats, to determine changes of lipasin expression in liver and in white adipose tissue (WAT) over 52 weeks in the relation to glucose tolerance, peripheral tissue insulin sensitivity and adiposity. GK rats were grossly glucose intolerant since the age of 6 weeks and developed peripheral insulin resistance at the age of 20 weeks. Expression of lipasin in the liver did not differ between GK and Wistar rats, declining with age, and it was not related to hepatic triacylglycerol content. In WAT, the lipasin expression was significantly higher in Wistar rats where it correlated positively with adiposity. No such correlation was found in GK rats. In conclusion, lipasin expression was associated neither with a mild age-related insulin resistance (Wistar), nor with severe genetically-based insulin resistance (GK).
authors.affiliation: Centre for Experimental Medicine, Department of Metabolism and Diabetes, Institute for Clinical and Experimental Medicine, Prague, Czech Republic. monika.cahova@ikem.cz.
authors.forename: M
authors.initials: M
authors.lastname: Cahová
authors.forename: D
authors.initials: D
authors.lastname: Habart
authors.forename: T
authors.initials: T
authors.lastname: Olejár
authors.forename: Z
authors.initials: Z
authors.lastname: Berková
authors.forename: Z
authors.initials: Z
authors.lastname: Papáčková
authors.forename: H
authors.initials: H
authors.lastname: Daňková
authors.forename: A
authors.initials: A
authors.lastname: Lodererova
authors.forename: M
authors.initials: M
authors.lastname: Heczková
authors.forename: F
authors.initials: F
authors.lastname: Saudek
mesh_terms: D052436:Adipose Tissue, White / Q000378:metabolism*; D000091306:Angiopoietin-Like Protein 8; D000075802:Angiopoietin-like Proteins / Q000378:metabolism*; D000818:Animals; D005786:Gene Expression Regulation / Q000502:physiology; D007333:Insulin Resistance / Q000502:physiology*; D008099:Liver / Q000378:metabolism*; D009928:Organ Specificity / Q000502:physiology; D036361:Peptide Hormones / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013045:Species Specificity
chemical_list: D000091306:Angiopoietin-Like Protein 8; D000075802:Angiopoietin-like Proteins; C000634101:Angptl8 protein, rat; D036361:Peptide Hormones