title: Histopathology and Florbetaben PET in Patients Incorrectly Diagnosed with Alzheimer's Disease.
abstract: Of 57 individuals diagnosed with Alzheimer's disease (AD) in a phase III study, 13 (23%) had amyloid-β (Aβ) levels on postmortem histopathology that did not explain the dementia. Based on postmortem histopathology, a wide range of different non-AD conditions was identified, including frontotemporal dementia, hippocampal sclerosis, and dementia with Lewy bodies. Of the histopathologically Aβ negative scored cases ante-mortem Florbetaben PET scans were classified as negative for Aβ in 11 patients based on visual analysis and in all 12 quantifiable cases based on composite standardized uptake value ratios. Thus, florbetaben PET can assist physicians in the differential diagnosis of neurodegenerative disorders by reliably excluding Aβ pathology.
authors.affiliation: Alzheimer's and Memory Disorders Division, Barrow Neurological Institute, Phoenix, AZ, USA.
authors.forename: Marwan N
authors.initials: MN
authors.lastname: Sabbagh
authors.affiliation: Formerly Piramal Imaging GmbH, Berlin, Germany.
authors.forename: Barbara
authors.initials: B
authors.lastname: Schäuble
authors.affiliation: Alzheimer's and Memory Disorders Division, Barrow Neurological Institute, Phoenix, AZ, USA.
authors.forename: Keshav
authors.initials: K
authors.lastname: Anand
authors.affiliation: Banner Sun Health Research Institute, Sun City, AZ, USA.
authors.forename: Danielle
authors.initials: D
authors.lastname: Richards
authors.affiliation: Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan.|Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
authors.forename: Shigeo
authors.initials: S
authors.lastname: Murayama
authors.affiliation: Fukushimura Hospital, Toyohashi, Japan.|Departments of Community-based Medicine and Neurology, Nagoya City University Graduate School of Medical Sciences, Nagoya City, Aichi, Japan.
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Akatsu
authors.affiliation: Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.|Mihara Memorial Hospital, Isesaki, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Takao
authors.affiliation: Austin Health, University of Melbourne, Melbourne, VIC, Australia.
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Rowe
authors.affiliation: The Florey Institute, The University of Melbourne, Australia.
authors.forename: Colin L
authors.initials: CL
authors.lastname: Masters
authors.affiliation: Department of Nuclear Medicine, Leipzig University, Leipzig, Germany.
authors.forename: Henryk
authors.initials: H
authors.lastname: Barthel
authors.affiliation: Department of Psychiatry, Leipzig University, Leipzig, Germany.
authors.forename: Hermann-Josef
authors.initials: HJ
authors.lastname: Gertz
authors.affiliation: Department of Psychiatry and Psychotherapy, Charité Berlin, Berlin, Germany.
authors.forename: Oliver
authors.initials: O
authors.lastname: Peters
authors.affiliation: Department of Psychiatry, Stanford School of Medicine, Stanford, USA.
authors.forename: Natalie
authors.initials: N
authors.lastname: Rasgon
authors.affiliation: Piramal Imaging GmbH, Berlin, Germany.
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Jovalekic
authors.affiliation: Department of Nuclear Medicine, Leipzig University, Leipzig, Germany.
authors.forename: Osama
authors.initials: O
authors.lastname: Sabri
authors.affiliation: Georg-August University Göttingen, Göttingen, Germany.
authors.forename: Walter J
authors.initials: WJ
authors.lastname: Schulz-Schaeffer
authors.affiliation: Molecular Neuroimaging, New Haven, CT, USA.
authors.forename: John
authors.initials: J
authors.lastname: Seibyl
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology*; D016229:Amyloid beta-Peptides / Q000378:metabolism; D000814:Aniline Compounds; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D013267:Stilbenes
chemical_list: D016229:Amyloid beta-Peptides; D000814:Aniline Compounds; D019275:Radiopharmaceuticals; D013267:Stilbenes; C527756:4-(N-methylamino)-4'-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)stilbene
keywords: Alzheimer’s disease; florbetaben PET; histopathology