title: To use or not to use the force: How B lymphocytes extract surface-tethered antigens.
abstract: Using an exquisite cell imaging approach based on DNA nanosensors, Spillane and Tolar (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201607064) explore how the physical properties of antigen-presenting cell surfaces affect how B cells internalize surface-tethered antigens. Soft and flexible surfaces promote mechanical force-mediated antigen extraction, whereas stiff surfaces lead to enzyme-mediated antigen release before subsequent internalization.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale U932, Institut Curie, 75005 Paris, France.
authors.forename: Paolo
authors.initials: P
authors.lastname: Pierobon
authors.affiliation: Institut National de la Santé et de la Recherche Médicale U932, Institut Curie, 75005 Paris, France ana-maria.lennon@curie.fr.
authors.forename: Ana-Maria
authors.initials: AM
authors.lastname: Lennon-Duménil
mesh_terms: D000938:Antigen-Presenting Cells; D000941:Antigens / Q000276:immunology; D000954:Antigens, Surface; D001402:B-Lymphocytes / Q000276:immunology; D006801:Humans; D011947:Receptors, Antigen, B-Cell / Q000276:immunology*
chemical_list: D000941:Antigens; D000954:Antigens, Surface; D011947:Receptors, Antigen, B-Cell