title: Construction of Chiral Tetraorganosilicons by Tandem Desymmetrization of Silacyclobutanes/Intermolecular Dehydrogenative Silylation.
abstract: We report a method to construct chiral tetraorganosilicons by tandem silacyclobutane (SCB) desymmetrization-dehydrogenative silylations. A wide array of dibenzosiloles with stereogenic quaternary silicon centers were obtained in good yields and enantioselectivities up to 93 % ee. Chiral TMS-segphos was found to be a superior ligand in terms of reactivity and enantioselectivity.
authors.affiliation: School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China.
authors.forename: Qing-Wei
authors.initials: QW
authors.lastname: Zhang
authors.affiliation: School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China.
authors.forename: Kun
authors.initials: K
authors.lastname: An
authors.affiliation: School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China.
authors.forename: Li-Chuan
authors.initials: LC
authors.lastname: Liu
authors.affiliation: School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China.
authors.forename: Huifang
authors.initials: H
authors.lastname: Guo
authors.affiliation: School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China.
authors.forename: Wei
authors.identifier: 0000-0001-8167-9155
authors.initials: W
authors.lastname: He
keywords: dibenzosiloles; enantioselectivity; silacyclobutanes; tetraorganosilicons