title: Cardiometabolic risk is associated with the severity of sleep-disordered breathing in children with obesity.
abstract: The alarming progression of pediatric obesity is associated with the development of sleep-disordered breathing (SDB), and both exhibit similar adverse cardiometabolic health outcomes. Physical activity level (PAL) may counteract sleep and metabolic disturbances. The present study investigates i) the association between the metabolic syndrome in childhood obesity and SDB, ii) the impact of SDB severity on cardiometabolic risk scores and PAL in children with obesity.
  
  
  
  Maturation status (Tanner stages), anthropometric (height, weight, body mass index, waist circumference, body adiposity index) and cardiometabolic characteristics (systolic and diastolic blood pressure, lipid and glycemic profiles) were assessed in 83 obese children (mean±SD, age: 10.7±2.7years). PAL and SDB were investigated with a step test and interviews, and an overnight sleep monitor, respectively. The presence or absence of metabolic syndrome (MS) was established and continuous cardiometabolic risk scores were calculated (MetScoreBMIand MetScoreWC).
  
  
  
  Obese children with (61.4%) and without (38.6%) MS present similar SDB. SDB severity is associated with increased insulin concentrations, MetScoreBMIand MetScoreWC(p<0.05) in obese children. There is no association between SDB and PAL.
  
  
  
  In a context where no consensus exists for SDB diagnosis in children, our results suggest the influence of SDB severity on cardiometabolic risk factors. Further studies are needed to explore the association between PAL and both metabolic and sleep alterations in obese children.
authors.affiliation: EA3920, Exercise Performance Health Innovation Platform, University of Bourgogne Franche-Comte, France, CHRU Jean Minjoz. Boulevard Fleming, F-25000 Besançon, France; Sports Science Faculty, University of Bourgogne Franche-Comte, France, 31 chemin de l'Epitaphe. F-25000 Besançon, France. Electronic address: laurie.isacco@univ-fcomte.fr.
authors.forename: Laurie
authors.initials: L
authors.lastname: Isacco
authors.affiliation: EA3920, Exercise Performance Health Innovation Platform, University of Bourgogne Franche-Comte, France, CHRU Jean Minjoz. Boulevard Fleming, F-25000 Besançon, France; Sports Science Faculty, University of Bourgogne Franche-Comte, France, 31 chemin de l'Epitaphe. F-25000 Besançon, France; Sleep and Health Medicine Center, Franois, France, Ellipse. 9 chemin des quatre Journaux, 25770 Franois, France. Electronic address: johanna.roche@edu.univ-fcomte.fr.
authors.forename: Johanna
authors.initials: J
authors.lastname: Roche
authors.affiliation: EA3920, Exercise Performance Health Innovation Platform, University of Bourgogne Franche-Comte, France, CHRU Jean Minjoz. Boulevard Fleming, F-25000 Besançon, France; Pediatric Obesity Prevention and Rehabilitation Department, Besançon, France, RéPPOP-FC-CHRU St Jacques, 2 place St Jacques, F-25000, Besançon cedex, France. Electronic address: s.quinart@free.fr.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Quinart
authors.affiliation: Laboratory of the Metabolic Adaptations to Exercise under Physiological and Pathological Conditions (AME2P), UE3533, Clermont Auvergne University, Clermont-Ferrand, Campus Universitaire des Cézeaux, 5 impasse Amélie Murat, 63178 Aubière cedex, France; Auvergne Research Center for Human Nutrition (CRNH), 58 Rue Montalembert, 63009 Clermont-Ferrand, France. Electronic address: thiveldavid@hotmail.com.
authors.forename: David
authors.initials: D
authors.lastname: Thivel
authors.affiliation: Sleep and Health Medicine Center, Franois, France, Ellipse. 9 chemin des quatre Journaux, 25770 Franois, France. Electronic address: vgillet@ellipse-sommeil.org.
authors.forename: Valérie
authors.initials: V
authors.lastname: Gillet
authors.affiliation: Pediatric Obesity Prevention and Rehabilitation Department, Besançon, France, RéPPOP-FC-CHRU St Jacques, 2 place St Jacques, F-25000, Besançon cedex, France. Electronic address: veronique-negre@wanadoo.fr.
authors.forename: Véronique
authors.initials: V
authors.lastname: Nègre
authors.affiliation: EA3920, Exercise Performance Health Innovation Platform, University of Bourgogne Franche-Comte, France, CHRU Jean Minjoz. Boulevard Fleming, F-25000 Besançon, France; Sports Science Faculty, University of Bourgogne Franche-Comte, France, 31 chemin de l'Epitaphe. F-25000 Besançon, France. Electronic address: fabienne.mougin-guillaume@univ-fcomte.fr.
authors.forename: Fabienne
authors.initials: F
authors.lastname: Mougin
mesh_terms: D000293:Adolescent; D000886:Anthropometry; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D002648:Child; D002675:Child, Preschool; D015444:Exercise; D005260:Female; D006331:Heart Diseases / Q000097:blood / Q000150:complications / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008659:Metabolic Diseases / Q000097:blood / Q000150:complications / Q000453:epidemiology*; D009765:Obesity / Q000097:blood / Q000150:complications / Q000453:epidemiology*; D012307:Risk Factors; D012720:Severity of Illness Index; D012891:Sleep Apnea Syndromes / Q000097:blood / Q000150:complications / Q000453:epidemiology*
chemical_list: D015415:Biomarkers
keywords: Children; MetScore; Obesity; Physical activity; Sleep