title: No Association of Obesity and Type 2 Diabetes Mellitus Related Genetic Variants With Colon Cancer.
abstract: BACKGROUND
  Obesity and type 2 diabetes mellitus (T2D) are known risk factors for colon cancer. Recent reports from a number of genome wide association studies (GWAS) have identified several single nucleotide polymorphisms (SNPs) associated with obesity and T2D. Here we tested the hypothesis that these SNPs may also be associated with risk of colon cancer.
  
  
  METHODS
  We genotyped nine SNPs reported in GWAS of obesity and/or T2D, including SNPs in HHEX, KCNJ11, SLC30A8, FTO, CDKN2, CDKAL1, TCF2, and the rs9300039 SNP in an intergenic region, in 561 colon cancer cases and 721 population controls.
  
  
  RESULTS
  None of these SNPs were statistically significantly associated with colon cancer in our sample.
  
  
  CONCLUSIONS
  Overall, these results suggest that these obesity and T2D genetic susceptibility loci are unlikely to influence the risk of colon cancer.
authors.affiliation: Departments of Family Medicine, Case Western Reserve University/University Hospitals of Cleveland, 10900 Euclid Ave, Cleveland, OH 44106, USA; Epidemiology and Biostatistics, Case Western Reserve University/University Hospitals of Cleveland, 10900 Euclid Ave, Cleveland, OH 44106, USA; The Case Center for Transdisciplinary Research on Energetics and Cancer, Case Comprehensive Cancer Center, 10900 Euclid Ave, Cleveland, OH 44106, USA.
authors.forename: Cheryl L
authors.initials: CL
authors.lastname: Thompson
authors.affiliation: Department of Preventive Medicine, University of Southern California, 1975 Zonal Ave, Los Angeles, CA 90089, USA.
authors.forename: Sarah J
authors.initials: SJ
authors.lastname: Plummer
authors.affiliation: Cancer Control Program, University of Kentucky, 2365 Harrodsburg Rd, Lexington, KY 40504, USA.
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Tucker
authors.affiliation: Department of Preventive Medicine, University of Southern California, 1975 Zonal Ave, Los Angeles, CA 90089, USA.
authors.forename: Graham
authors.initials: G
authors.lastname: Casey
authors.affiliation: Departments of Family Medicine, Case Western Reserve University/University Hospitals of Cleveland, 10900 Euclid Ave, Cleveland, OH 44106, USA; Epidemiology and Biostatistics, Case Western Reserve University/University Hospitals of Cleveland, 10900 Euclid Ave, Cleveland, OH 44106, USA; The Case Center for Transdisciplinary Research on Energetics and Cancer, Case Comprehensive Cancer Center, 10900 Euclid Ave, Cleveland, OH 44106, USA.
authors.forename: Li
authors.initials: L
authors.lastname: Li
keywords: Association; Colon cancer; Obesity; Single nucleotide polymorphisms; Type 2 diabetes