title: In Vivo Imaging of Tau Aggregates in the Mouse Retina.
abstract: Aggregates of hyperphosphorylated tau can be observed in the human brain affected by various neurodegenerative disorders. The development of a noninvasive technique for the visualization of these protein accumulations is a promising task. In the following protocol, we describe a method to image fibrillar tau in the retina of a transgenic mouse model of frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17). This technique can be highly valuable for the preclinical in vivo testing of approaches that target tau aggregation.
authors.affiliation: Center for Neuropathology, Ludwig-Maximilian-University, Munich, Germany. christian.schoen@cup.uni-muenchen.de.|Department of Translational Brain Research, DZNE - German Centre for Neurodegenerative Diseases, Munich, Germany. christian.schoen@cup.uni-muenchen.de.
authors.forename: Christian
authors.initials: C
authors.lastname: Schön
authors.affiliation: Department of Translational Brain Research, DZNE - German Centre for Neurodegenerative Diseases, Munich, Germany.
authors.forename: Jochen
authors.initials: J
authors.lastname: Herms
mesh_terms: D000818:Animals; D003952:Diagnostic Imaging / Q000379:methods*; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D009154:Mutation / Q000235:genetics; D012160:Retina / Q000378:metabolism* / Q000473:pathology*; D024801:Tauopathies / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D016875:tau Proteins / Q000378:metabolism*
chemical_list: D016875:tau Proteins
keywords: Confocal scanning laser ophthalmoscopy; FSB; P301S mutant mice; Tau protein; Tauopathies