title: Comparative analysis of human milk and infant formula derived peptides following in vitro digestion.
abstract: It has long been recognised that there are differences between human milk and infant formulas which lead to differences in health and nutrition for the neonate. In this study we examine and compare the peptide profile of human milk and an exemplar infant formula. The study identifies both similarities and differences in the endogenous and postdigestion peptide profiles of human milk and infant formula. This includes differences in the protein source of these peptides but also with the region within the protein producing the dominant proteins. Clustering of similar peptides around regions of high sequence identity and known bioactivity was also observed. Together the data may explain some of the functional differences between human milk and infant formula, while identifying some aspects of conserved function between bovine and human milks which contribute to the effectiveness of modern infant formula as a substitute for human milk.
authors.affiliation: State Key Laboratory of Dairy Biotechnology, Dairy Research Institute, Bright Dairy & Food Co., Ltd., Shanghai, China.
authors.forename: M-Y
authors.initials: MY
authors.lastname: Su
authors.affiliation: AgResearch Ltd, Ruakura Research Centre, Hamilton, New Zealand.
authors.forename: M
authors.initials: M
authors.lastname: Broadhurst
authors.affiliation: State Key Laboratory of Dairy Biotechnology, Dairy Research Institute, Bright Dairy & Food Co., Ltd., Shanghai, China.
authors.forename: C-P
authors.initials: CP
authors.lastname: Liu
authors.affiliation: AgResearch Ltd, Cnr Springs Road and Gerald Street, Private Bag 4749, Christchurch 8140, New Zealand.
authors.forename: J
authors.initials: J
authors.lastname: Gathercole
authors.affiliation: State Key Laboratory of Dairy Biotechnology, Dairy Research Institute, Bright Dairy & Food Co., Ltd., Shanghai, China.
authors.forename: W-L
authors.initials: WL
authors.lastname: Cheng
authors.affiliation: State Key Laboratory of Dairy Biotechnology, Dairy Research Institute, Bright Dairy & Food Co., Ltd., Shanghai, China.
authors.forename: X-Y
authors.initials: XY
authors.lastname: Qi
authors.affiliation: AgResearch Ltd, Cnr Springs Road and Gerald Street, Private Bag 4749, Christchurch 8140, New Zealand; Biomolecular Interaction Centre, University of Canterbury, Christchurch, New Zealand.
authors.forename: S
authors.initials: S
authors.lastname: Clerens
authors.affiliation: AgResearch Ltd, Cnr Springs Road and Gerald Street, Private Bag 4749, Christchurch 8140, New Zealand; Biomolecular Interaction Centre, University of Canterbury, Christchurch, New Zealand; Riddet Institute, based at Massey University, Palmerston North, New Zealand; Wine, Food & Molecular Biosciences, Lincoln University, Lincoln, New Zealand.
authors.forename: J M
authors.initials: JM
authors.lastname: Dyer
authors.affiliation: AgResearch Ltd, Grasslands Research Centre, Tennent Drive, Palmerston North 4442, New Zealand.
authors.forename: L
authors.initials: L
authors.lastname: Day
authors.affiliation: AgResearch Ltd, Ruakura Research Centre, Hamilton, New Zealand. Electronic address: brendan.haigh@agresearch.co.nz.
authors.forename: B
authors.initials: B
authors.lastname: Haigh
mesh_terms: D000818:Animals; D002417:Cattle; D004063:Digestion; D006801:Humans; D007223:Infant; D041943:Infant Formula / Q000737:chemistry*; D007231:Infant, Newborn; D008895:Milk, Human / Q000737:chemistry*; D010455:Peptides / Q000032:analysis*
chemical_list: D010455:Peptides
keywords: Bioactivity; Human milk; Infant formula; Peptides; Simulated digestion