title: Differentiated thyroid cancer in patients with prolactinoma.
abstract: OBJECTIVE
  Increasing evidence is available about the role of prolactin in the development of various cancers. The purpose of this study is to evaluate the frequency of thyroid cancer in patients with prolactinoma followed at a single site.
  
  
  METHODS
  The medical records of 182 patients diagnosed with prolactinoma were reviewed retrospectively. Serum prolactin, antithyroglobulin, antithyroid peroxidase antibody, thyroid-stimulating hormone, free T4, and free T3 values and pituitary gland magnetic resonance imaging and thyroid ultrasound reports were evaluated.
  
  
  RESULTS
  Forty-five (39.5%) patients were found to have a thyroid nodule (13 solitary, 32 multiple). Ten patients were administered a thyroidectomy, and differentiated thyroid cancer (DTC) was detected in 6 of these patients (6/114, 5.3%). One patient had lung metastasis. The control group consisted of 113 individuals (101 females, 12 males with a mean age of 32.1 ± 9.1). In the ultrasound reports, 28 of these individuals (24.8%) had a thyroid nodule (5 solitary, 23 multiple), and one individual (1/113, 0.8%) had DTC.
  
  
  CONCLUSIONS
  When compared to the control group, thyroid volume and thyroid nodularity were significantly higher in patients with prolactinoma (P < 0.001, P = 0.018, respectively); however, no statistically significant difference existed for the incidence of thyroid cancer (P = 0.196).
authors.affiliation: Department of Endocrinology and Metabolism, Atatürk Training and Research Hospital, Ankara, Turkey.
authors.forename: Abbas Ali
authors.initials: AA
authors.lastname: Tam
authors.affiliation: Department of Endocrinology and Metabolism, Atatürk Training and Research Hospital, Ankara, Turkey.
authors.forename: Cafer
authors.initials: C
authors.lastname: Kaya
authors.affiliation: Department of Endocrinology and Metabolism, Atatürk Training and Research Hospital, Ankara, Turkey.
authors.forename: Cevdet
authors.initials: C
authors.lastname: Aydın
authors.affiliation: Department of Endocrinology and Metabolism, Faculty of Medicine, Yıldırım Beyazıt University, Ankara, Turkey.
authors.forename: Reyhan
authors.initials: R
authors.lastname: Ersoy
authors.affiliation: Department of Endocrinology and Metabolism, Faculty of Medicine, Yıldırım Beyazıt University, Ankara, Turkey.
authors.forename: Bekir
authors.initials: B
authors.lastname: Çakır
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D015175:Prolactinoma; D013964:Thyroid Neoplasms; D013965:Thyroidectomy; D013972:Thyrotropin; D055815:Young Adult
chemical_list: D013972:Thyrotropin
keywords: Prolactinoma; prolactin; thyroid cancer; thyroid nodule; thyroid volume