title: Identification and characterization of cancer stem cells in canine mammary tumors.
abstract: Cancer stem cells (CSC) represent a small subpopulation of cells in malignant tumors that possess the unique ability to self-renew, differentiate and resist chemo- and radiotherapy. These cells have been postulated to be the basis for some of the difficulties in treating cancer, and therefore, numerous approaches have been developed to specifically target and eliminate CSC in diverse types of cancer, including breast cancer. Spontaneously occurring mammary tumors in canines share clinical and molecular similarities with the human counterpart, making the dog a potentially powerful model for the study of human breast cancer and clinical trials. Studies focused on canine mammary CSC might therefore enhance our understanding of the biology and possible treatment of the disease in both dogs and humans. In this review, we discuss various approaches currently in use to isolate and characterize canine mammary CSC.
authors.affiliation: Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Warsaw, Poland. rybicka.agt@gmail.com.
authors.forename: Agata
authors.identifier: http://orcid.org/0000-0002-7749-8850
authors.initials: A
authors.lastname: Rybicka
authors.affiliation: Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Warsaw, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Król
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000473:pathology; D004195:Disease Models, Animal; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005260:Female; D006801:Humans; D015674:Mammary Neoplasms, Animal / Q000473:pathology*; D014411:Neoplastic Stem Cells / Q000473:pathology*
keywords: Cancer stem cells; Canine mammary tumor; Translational medicine