title: The changing phenotype of iodine deficiency disorders: a review of thirty-five years of research in north-eastern Sicily.
abstract: Iodine deficiency disorders (IDD) still represent a major public health problem, with almost 30% of the world population being exposed to the consequences of nutritional iodine deficiency (ID). In Italy, despite a sustained policy of iodine prophylaxis, more than 10% of people is still affected with goiter, and a presumably higher rate of subjects may suffer from minor cognitive deficits due to inadequate iodine supply during antenatal life. This review of systematic observational studies carried out over thirty-five years (1980-2015) in a sentinel ID area in North-eastern Sicily highlights the changing phenotypes of IDD in this region. Over the years profound improvements in nutritional iodine status in North-eastern Sicily has occurred, due to both silent and active iodine prophylaxis. Endemic cretinism, resulting from severe iodine deficiency, has been progressively replaced by less serious deficits of intellectual and cognitive abilities, which nevertheless deserve proper attention.
authors.affiliation: Dipartimento di Medicina Clinica e Sperimentale, Università di Messina, Messina, Italy.
authors.forename: Mariacarla
authors.initials: M
authors.lastname: Moleti
authors.affiliation: Dipartimento di Medicina Clinica e Sperimentale, Università di Messina, Messina, Italy.
authors.forename: Giacomo
authors.initials: G
authors.lastname: Sturniolo
authors.affiliation: Dipartimento di Medicina Clinica e Sperimentale, Università di Messina, Messina, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Trimarchi
authors.affiliation: Dipartimento di Medicina Clinica e Sperimentale, Università di Messina, Messina, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Vermiglio
mesh_terms: D003409:Congenital Hypothyroidism / Q000453:epidemiology; D003677:Deficiency Diseases / Q000178:diet therapy / Q000453:epidemiology*; D006801:Humans; D007455:Iodine / Q000172:deficiency*; D017613:Iodine Compounds / Q000627:therapeutic use; D010641:Phenotype; D012802:Sicily / Q000453:epidemiology
chemical_list: D017613:Iodine Compounds; D007455:Iodine