title: Dependency of endothelial cell loss on anterior chamber depth within first 4 years after implantation of iris-supported phakic intraocular lenses to treat high myopia.
abstract: To evaluate the effect of the anterior chamber depth (ACD) on the central corneal endothelial cell density (ECD) in eyes after implantation of an iris-fixated phakic intraocular lens (pIOL).
  
  
  
  Department of Ophthalmology, Goethe-University, Frankfurt, Germany.
  
  
  
  Retrospective nonrandomized case series.
  
  
  
  An Artisan pIOL was implanted in eyes of highly myopic patients. Follow-up examinations at 1, 12, 24, 36, and 48 months included evaluation of ECD and adverse events. Three cohorts based on the ACD were established and their ECDs compared. All eyes had 1-year and 4-year postoperative ECD measurements available. Statistical analysis included linear regression analysis to evaluate the influence of ACD on ECD.
  
  
  
  The study comprised 95 eyes (52 patients). Four years after surgery the mean spherical equivalent changed from -11.06 diopters (D) ± 4.77 (SD) to -0.42 ± 0.47 D. Severe adverse events were not detected. There was a significantly higher ECD loss after 4 years in patients with an ACD of less than 3.00 mm than in those with an ACD greater than 3.40 mm (-224 cells/mm2) (P < .01). There was no significant difference in ECD between eyes with an ACD of 3.00 to 3.39 mm and eyes with an ACD less than 3.00 mm (P = .23) or more than 3.40 mm (P = .08).
  
  
  
  The iris-claw pIOL precisely and safely corrected high myopia. However, the loss in ECD can be considerable. Establishing stricter exclusion criteria for ACD might reduce this loss.
  
  
  
  Proprietary or commercial disclosures are listed after the references.
authors.affiliation: From the Department of Ophthalmology, Goethe-University, Frankfurt am Main, Germany.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Shajari
authors.affiliation: From the Department of Ophthalmology, Goethe-University, Frankfurt am Main, Germany.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Scheffel
authors.affiliation: From the Department of Ophthalmology, Goethe-University, Frankfurt am Main, Germany.
authors.forename: Michael Janusz
authors.initials: MJ
authors.lastname: Koss
authors.affiliation: From the Department of Ophthalmology, Goethe-University, Frankfurt am Main, Germany. Electronic address: kohnen@em.uni-frankfurt.de.
authors.forename: Thomas
authors.initials: T
authors.lastname: Kohnen
mesh_terms: D000867:Anterior Chamber; D002452:Cell Count; D015331:Cohort Studies; D042783:Endothelial Cells; D005500:Follow-Up Studies; D005858:Germany; D006801:Humans; D007498:Iris; D019654:Lens Implantation, Intraocular; D009216:Myopia / Q000628:therapy*; D054120:Phakic Intraocular Lenses; D012189:Retrospective Studies