title: Antiplasmodial dimeric chalcone derivatives from the roots of Uvaria siamensis.
abstract: Four dimeric chalcone derivatives, 8″,9″-dihydrowelwitschin H, uvarins A-C, a naphthalene derivative, 2-hydroxy-3-methoxy-6-(4'- hydroxyphenyl)naphthalene, and the known dimeric chalcones, dependensin and welwitschin E, flavonoids, a cyclohexane oxide derivative, an aromatic aldehyde were isolated from the roots of Uvaria siamensis (Annonaceae). The structures of the compounds were elucidated by spectroscopic analysis, as well as by comparison with literature data. The isolated compounds with a sufficient amount for biological assays were evaluated for their antimalarial, antimycobacterial, and cytotoxic activities. The dimeric chalcones 8″,9″-dihydrowelwitschin H, uvarins B and C, dependensin and welwitschin E showed strong antiplasmodial activity with IC50values of 3.10, 3.02, 3.09, 4.21 and 3.99 μg/mL, respectively. A possible biosynthesis pathway of the dimeric chalcones is discussed.
authors.affiliation: Laboratory of Natural Products Chemistry, Faculty of Science and Technology, Phuket Rajabhat University, Muang, Phuket 83000, Thailand. Electronic address: wahab_a@pkru.ac.th.
authors.forename: Abdul-Wahab
authors.initials: AW
authors.lastname: Salae
authors.affiliation: Laboratory of Natural Products Chemistry, Faculty of Science and Technology, Phuket Rajabhat University, Muang, Phuket 83000, Thailand.
authors.forename: Orapan
authors.initials: O
authors.lastname: Chairerk
authors.affiliation: Laboratory of Natural Products Chemistry, Faculty of Science and Technology, Phuket Rajabhat University, Muang, Phuket 83000, Thailand.
authors.forename: Piyanut
authors.initials: P
authors.lastname: Sukkoet
authors.affiliation: Laboratory of Natural Products Chemistry, Faculty of Science and Technology, Phuket Rajabhat University, Muang, Phuket 83000, Thailand.
authors.forename: Therdsak
authors.initials: T
authors.lastname: Chairat
authors.affiliation: Laboratory of Natural Products Chemistry, Faculty of Science and Technology, Phuket Rajabhat University, Muang, Phuket 83000, Thailand. Electronic address: umaprawat@pkru.ac.th.
authors.forename: Uma
authors.initials: U
authors.lastname: Prawat
authors.affiliation: Laboratory of Natural Products Chemistry, Faculty of Science and Technology, Phuket Rajabhat University, Muang, Phuket 83000, Thailand.
authors.forename: Pittaya
authors.initials: P
authors.lastname: Tuntiwachwuttikul
authors.affiliation: Thailand Institute of Scientific and Technological Research, Pathum Thani 12120, Thailand.
authors.forename: Piya
authors.initials: P
authors.lastname: Chalermglin
authors.affiliation: Chulabhorn Research Institute, Kamphaeng Phet 6 Road, Bangkok 10210, Thailand; Chulabhorn Graduate Institute, Center for Environmental Health and Toxicology (EHT), Kamphaeng Phet 6 Road, Bangkok 10210, Thailand.
authors.forename: Somsak
authors.initials: S
authors.lastname: Ruchirawat
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D047188:Chalcones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry*; D031046:Uvaria / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D000962:Antimalarials; D047188:Chalcones; D005419:Flavonoids
keywords: Annonaceae; Antimycobacterial; Antiplasmodial; Cytotoxicity; Dimeric chalcone; Uvaria siamensis