title: Genotypic carriers of the obesity-associated FTO polymorphism exhibit different cardiometabolic profiles after an intervention.
abstract: Children and adolescents with at-risk genotypes (AA/AT) of the rs9939609 polymorphism in FTO, a fat mass and obesity-associated gene, may exhibit different cardiometabolic profile responses than subjects with the TT genotype after an interdisciplinary intervention.
  The sample consisted of 36 school children from southern Brazil. We used DNA quantitation and real-time polymerase chain reaction (PCR) for polymorphism genotyping. We measured anthropometric parameters (body mass index (BMI), waist circumference, hip circumference, waist-hip ratio, body fat percentage and skinfold sum), biochemical parameters (glucose, lipid profile, ultra-sensitive C-reactive protein, uric acid, alanine aminotransferase, aspartate aminotransferase, insulin and adiponectin) and blood pressure. The 4-month intervention consisted of physical education classes, nutritional counseling, and postural and oral health counseling.
  We observed no significant differences among the groups (AA, AT and TT) after the intervention. However, we observed improvements in three parameters (waist circumference, hip circumference and C-reactive protein) in the AT/AA genotype group and in two parameters (hip circumference and uric acid) in the TT genotype group.
  After an intervention program, carriers of at-risk genotypes for obesity (AA/AT) do not exhibit differences in biochemical parameters, blood pressure and anthropometric parameters compared with carriers of the TT genotype.
authors.affiliation: Postgraduate Program in Health Promotion, University of Santa Cruz do Sul, Av. Independência, 2293, Bloco 42, Sala 4206, Bairro Universitário, 96815-900 Santa Cruz do Sul, RS, Brazil.
authors.forename: Greice G
authors.initials: GG
authors.lastname: Moraes
authors.affiliation: Physical Education and Health Department, University of Santa Cruz do Sul, Av. Independência, 2293, Bloco 42, Sala 4201, Bairro Universitário, 96815-900 Santa Cruz do Sul, RS, Brazil.
authors.forename: Cézane P
authors.initials: CP
authors.lastname: Reuter
authors.affiliation: Postgraduate Program in Health Promotion, University of Santa Cruz do Sul, Av. Independência, 2293, Bloco 42, Sala 4206, Bairro Universitário, 96815-900 Santa Cruz do Sul, RS, Brazil.
authors.forename: Jane D P
authors.initials: JD
authors.lastname: Renner
authors.affiliation: Postgraduate Program in Health Promotion, University of Santa Cruz do Sul, Av. Independência, 2293, Bloco 42, Sala 4206, Bairro Universitário, 96815-900 Santa Cruz do Sul, RS, Brazil.
authors.forename: Elisa I
authors.initials: EI
authors.lastname: Klinger
authors.affiliation: Department of Biology and Pharmacy. University of Santa Cruz do Sul, Av. Independência, 2293, Bloco 35, Bairro Universitário, 96815-900 Santa Cruz do Sul, RS, Brazil.
authors.forename: Michele B
authors.initials: MB
authors.lastname: Ferreira
authors.affiliation: Postgraduate Program in Child and Adolescent Health, Federal University of Rio Grande do Sul, Av. Ramiro Barcellos, 2400, Bairro Santana, 90035-903 Porto Alegre, RS, Brazil.
authors.forename: Elza D DE
authors.initials: ED
authors.lastname: Mello
authors.affiliation: Postgraduate Program in Health Promotion, University of Santa Cruz do Sul, Av. Independência, 2293, Bloco 42, Sala 4206, Bairro Universitário, 96815-900 Santa Cruz do Sul, RS, Brazil.
authors.forename: Andréia DE M
authors.initials: AM
authors.lastname: Valim
authors.affiliation: Postgraduate Program in Health Promotion, University of Santa Cruz do Sul, Av. Independência, 2293, Bloco 42, Sala 4206, Bairro Universitário, 96815-900 Santa Cruz do Sul, RS, Brazil.
authors.forename: Miria S
authors.initials: MS
authors.lastname: Burgos
mesh_terms: D000293:Adolescent; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO / Q000235:genetics*; D015992:Body Mass Index; D001938:Brazil; D002648:Child; D005081:Exercise Therapy; D005838:Genotype; D006801:Humans; D063766:Pediatric Obesity / Q000235:genetics* / Q000378:metabolism / Q000628:therapy; D020641:Polymorphism, Single Nucleotide; D012885:Skinfold Thickness; D055105:Waist Circumference; D049629:Waist-Hip Ratio
chemical_list: D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human