title: Alterations of the gut microbiome in Chinese patients with systemic lupus erythematosus.
abstract: BACKGROUND
  Systemic lupus erythematosus (SLE) in patients from Spain is associated with intestinal dysbiosis. This study explores whether the alteration of the gut microbiome in SLE patients from China is consistent with the intestinal dysbiosis of SLE patients from Spain.
  
  
  RESULTS
  The depletion of Firmicutes and the enrichment of Bacteroidetes in SLE patients from China were consistent with the SLE patients from Spain. Furthermore, we found that nine genera of gut microbiota were SLE-related microorganisms in Chinese subjects. GeneraRhodococcus,Eggerthella,Klebsiella,Prevotella,Eubacterium, FlavonifractorandIncertae sediswere significantly enriched, while generaDialisterandPseudobutyrivibriowere significantly depleted in SLE patients. Receiver operating characteristic analysis indicated that the nine genera have the potential to distinguish SLE patients from healthy controls.
  
  
  CONCLUSIONS
  Comparing the dysbiosis of the gut microbiome among SLE patients from China or Spain, may indicate that the gut microbiome profiles of SLE patients are more influenced by disease than ethnicity.
authors.affiliation: College of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou, 310053 China.
authors.forename: Zhixing
authors.initials: Z
authors.lastname: He
authors.affiliation: College of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou, 310053 China.
authors.forename: Tiejuan
authors.initials: T
authors.lastname: Shao
authors.affiliation: College of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou, 310053 China.
authors.forename: Haichang
authors.initials: H
authors.lastname: Li
authors.affiliation: College of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou, 310053 China.
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Xie
authors.affiliation: College of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou, 310053 China.
authors.forename: Chengping
authors.initials: C
authors.lastname: Wen
keywords: Chinese patients; Genus level; Gut microbiome; Illumina Miseq; Systemic lupus erythematosus