title: Absorption of Orally Administered Hyaluronan.
abstract: Hyaluronan (HA) has been utilized as a supplement. However, the absorption of orally administrated HA remains controversial. The degradation and absorption of HA in the intestine were investigated in this study. HA excretion into the feces, degradation in the intestinal tract, absorption through the large intestine, and translocation to the blood and skin were examined. HA administered orally was not detected in rat feces. HA was degraded by cecal content, but not by artificial gastric juice and intestinal juice. Oligosaccharide HA passed through excised large intestine sacs. Furthermore, disaccharides, tetrasaccharides, and polysaccharides HA were distributed to the skin of rats following oral administration of high molecular weight HA (300 kDa). The results of the study suggest that orally administered HA is degraded to oligosaccharides by intestinal bacteria, and oligosaccharide HA is absorbed in the large intestine and is subsequently distributed throughout the tissues, including the skin.
authors.affiliation: 1 R&D Division, Kewpie Corporation , Sengawa Kewport, Tokyo, Japan .|2 Facility of Agriculture, Scleroprotein and Leather Research Institute, Tokyo University of Agriculture and Technology , Tokyo, Japan .
authors.forename: Mamoru
authors.initials: M
authors.lastname: Kimura
authors.affiliation: 1 R&D Division, Kewpie Corporation , Sengawa Kewport, Tokyo, Japan .
authors.forename: Takuya
authors.initials: T
authors.lastname: Maeshima
authors.affiliation: 1 R&D Division, Kewpie Corporation , Sengawa Kewport, Tokyo, Japan .
authors.forename: Takumi
authors.initials: T
authors.lastname: Kubota
authors.affiliation: 1 R&D Division, Kewpie Corporation , Sengawa Kewport, Tokyo, Japan .
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Kurihara
authors.affiliation: 1 R&D Division, Kewpie Corporation , Sengawa Kewport, Tokyo, Japan .
authors.forename: Yasunobu
authors.initials: Y
authors.lastname: Masuda
authors.affiliation: 2 Facility of Agriculture, Scleroprotein and Leather Research Institute, Tokyo University of Agriculture and Technology , Tokyo, Japan .
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Nomura
mesh_terms: D000818:Animals; D001419:Bacteria / Q000378:metabolism; D002432:Cecum / Q000378:metabolism; D019587:Dietary Supplements; D005243:Feces / Q000737:chemistry; D005753:Gastric Mucosa / Q000378:metabolism; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics*; D007408:Intestinal Absorption; D007422:Intestines / Q000382:microbiology; D008297:Male; D009844:Oligosaccharides / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000378:metabolism
chemical_list: D009844:Oligosaccharides; D006820:Hyaluronic Acid
keywords: degradation; intestine; oligosaccharides