title: Access to Complex C2-Branched Glycoconjugates via Palladium-Catalyzed Aminocarbonylation Reaction of 2-Iodoglycals.
abstract: A convenient and straightforward synthesis of 2-amidoglycals through a palladium-catalyzed aminocarbonylation reaction between 2-iodoglycal partners and diverse amines in the presence of a "CO" source has been developed. Several amines such as aliphatics, benzylics, or aromatics are compatible with our reaction conditions as well as sulfonamides. Further deprotection steps have been successfully applied, leading to glycoside mimics. This method constitutes a new route to access original glycopeptide- and glycolipid-type analogues possessing a C-C bond at the C2-position.
authors.affiliation: Laboratoire de Chimie Biologique (LCB), Université de Cergy-Pontoise , EA 4505, 5 Mail Gay-Lussac, 95031 Cergy-Pontoise, France.
authors.forename: Andrea
authors.initials: A
authors.lastname: Bordessa
authors.affiliation: Laboratoire de Chimie Biologique (LCB), Université de Cergy-Pontoise , EA 4505, 5 Mail Gay-Lussac, 95031 Cergy-Pontoise, France.
authors.forename: Angélique
authors.initials: A
authors.lastname: Ferry
authors.affiliation: Laboratoire de Chimie Biologique (LCB), Université de Cergy-Pontoise , EA 4505, 5 Mail Gay-Lussac, 95031 Cergy-Pontoise, France.
authors.forename: Nadège
authors.identifier: 0000-0003-0713-9286
authors.initials: N
authors.lastname: Lubin-Germain