title: Cerebrospinal Fluid Findings in Neurological Diseases Associated with Sjögren's Syndrome.
abstract: Sjögren's syndrome is a chronic autoimmune-mediated disease that can cause a variety of neurological manifestations.
  
  
  
  This study investigated characteristics of clinical and cerebrospinal fluid (CSF) features in patients with neurological diseases associated with Sjögren's syndrome. Eighty-two patients were examined separately according to the presence of Sjögren's syndrome alone or in combination with other autoimmune diseases.
  
  
  
  In the 47 patients with primary Sjögren's syndrome, peripheral neuropathy (57%) was found most frequently, followed by the involvement of the central nervous system (CNS; 17%), cranial neuropathy (15%), and myalgia (11%). These patients did not display consistent signs of inflammation in the CSF. Slight pleocytosis of 8-107 cells/µL was found in patients with peripheral neuropathy (9%), cranial neuropathy (20%), and CNS involvement (25%). Oligoclonal bands indicating intrathecal IgG synthesis occurred in 26% of patients with peripheral neuropathy, 20% of patients with cranial neuropathy, and 25% of patients with CNS involvement.
  
  
  
  In patients with Sjögren's syndrome and neurological manifestations, inflammatory CSF changes were rarely found and did not show a characteristic pattern irrespective of peripheral or central genesis of neurological deficits. Analysis of the CSF presents therefore an important diagnostic procedure to exclude other autoimmune and infectious diseases.
authors.affiliation: Clinical Neuroimmunology and Neurochemistry, Department of Neurology, Hannover Medical School, Hannover, Germany.
authors.forename: Kaweh
authors.initials: K
authors.lastname: Pars
authors.forename: Refik
authors.initials: R
authors.lastname: Pul
authors.forename: Philipp
authors.initials: P
authors.lastname: Schwenkenbecher
authors.forename: Kurt-Wolfram
authors.initials: KW
authors.lastname: Sühs
authors.forename: Ulrich
authors.initials: U
authors.lastname: Wurster
authors.forename: Torsten
authors.initials: T
authors.lastname: Witte
authors.forename: Paul
authors.initials: P
authors.lastname: Bronzlik
authors.forename: Martin
authors.initials: M
authors.lastname: Stangel
authors.forename: Thomas
authors.initials: T
authors.lastname: Skripuletz
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000134:cerebrospinal fluid* / Q000209:etiology*; D012859:Sjogren's Syndrome / Q000150:complications*