title: Goodpasture disease as a consequence of melioidosis.
abstract: We describe a case of anti-glomerular basement membrane (GBM) antibody-mediated disease in association with concomitant Burkholderia pseudomallei (melioidosis) bacteraemia. The temporal profile of the illness and initial absence of circulating anti-GBM antibodies, in light of the subsequent definitive histological diagnosis of anti-GBM disease, makes this case interesting and unusual. Additionally, there have been no prior case reports suggesting melioidosis as a cause of biopsy-proven glomerulonephritis.
authors.affiliation: Department of Medicine, Cairns Hospital, Cairns, Queensland, Australia.
authors.forename: D
authors.initials: D
authors.lastname: Mackintosh
authors.affiliation: Department of Nephrology, Cairns Hospital, Cairns, Queensland, Australia.
authors.forename: M
authors.initials: M
authors.lastname: Mantha
authors.affiliation: Department of Anatomical Pathology, Princess Alexandra Hospital, Brisbane, Queensland, Australia.
authors.forename: K
authors.initials: K
authors.lastname: Oliver
mesh_terms: D015746:Abdominal Pain; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D019867:Anti-Glomerular Basement Membrane Disease / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001323:Autoantibodies / Q000378:metabolism*; D023341:Chills; D005334:Fever; D005455:Fluorescent Antibody Technique; D006440:Hemofiltration / Q000379:methods*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000175:diagnosis* / Q000276:immunology / Q000503:physiopathology; D008297:Male; D008554:Melioidosis / Q000150:complications* / Q000276:immunology / Q000503:physiopathology; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D063806:Myalgia; D010951:Plasma Exchange / Q000379:methods; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D001323:Autoantibodies; C051951:antiglomerular basement membrane antibody; D008775:Methylprednisolone
keywords: Goodpasture syndrome; glomerulonephritis; melioidosis; renal biopsy