title: The Snowballing Literature on Imiquimod-Induced Skin Inflammation in Mice: A Critical Appraisal.
abstract: Since 2009, the imiquimod- or Aldara-induced (3M Pharmaceuticals, St. Paul, MN) model of acute skin inflammation has become the most widely used mouse model in preclinical psoriasis studies. Although this model offers researchers numerous benefits, there are important limitations and possible confounding variables to consider. The imiquimod model requires careful consideration and warrants scrutiny of the data generated by its use. In this perspective, we provide an overview of the advantages and disadvantages of this mouse model and offer suggestions for its use in psoriasis research.
authors.affiliation: Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah, USA; Laboratory for Investigative Dermatology, Rockefeller University, New York, New York, USA.
authors.forename: Jason E
authors.initials: JE
authors.lastname: Hawkes
authors.affiliation: Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA.
authors.forename: Johann E
authors.initials: JE
authors.lastname: Gudjonsson
authors.affiliation: Department of Dermatology, Case Western Reserve University, Cleveland, Ohio, USA. Electronic address: nlw4@case.edu.
authors.forename: Nicole L
authors.initials: NL
authors.lastname: Ward
mesh_terms: D000634:Aminoquinolines; D000818:Animals; D003872:Dermatitis; D003880:Dermatology / Q000639:trends; D004195:Disease Models, Animal; D006801:Humans; D000077271:Imiquimod; D007249:Inflammation / Q000139:chemically induced*; D051379:Mice; D011565:Psoriasis / Q000139:chemically induced* / Q000628:therapy*; D012107:Research Design
chemical_list: D000634:Aminoquinolines; D000077271:Imiquimod