title: Adhesion of mesenchymal stem cells to biomimetic polymers: A review.
abstract: The mesenchymal stem cells (MSCs) are promising candidates for cell therapy due to the self-renewal, multi-potency, ethically approved state and suitability for autologous transplantation. However, key issue for isolation and manipulation of MSCs is adhesion in ex-vivo culture systems. Biomaterials engineered for mimicking natural extracellular matrix (ECM) conditions which support stem cell adhesion, proliferation and differentiation represent a main area of research in tissue engineering. Some of them successfully enhanced cells adhesion and proliferation because of their biocompatibility, biomimetic texture, and chemistry. However, it is still in its infancy, therefore intensification and optimization of in vitro, in vivo, and preclinical studies is needed to clarify efficacies as well as applicability of those bioengineered constructs. The aim of this review is to discuss mechanisms related to the in-vitro adhesion of MSCs, surfaces biochemical, biophysical, and other factors (of cell's natural and artificial micro-environment) which could affect it and a review of previous research attempting for its bio-chemo-optimization.
authors.affiliation: Research Institute for Fundamental Sciences (RIFS), University of Tabriz, Tabriz, Iran.
authors.forename: Behnaz Banimohamad
authors.initials: BB
authors.lastname: Shotorbani
authors.affiliation: Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran; Drug Applied Research Center and Faculty of advanced Medical Science, Tabriz University of Medical Sciences, Tabriz, Iran; The Umbilical Cord Stem Cell Research Center (UCSRC), Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: Alizadehe@tbzmed.ac.ir.
authors.forename: Effat
authors.initials: E
authors.lastname: Alizadeh
authors.affiliation: Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran; Drug Applied Research Center and Faculty of advanced Medical Science, Tabriz University of Medical Sciences, Tabriz, Iran; The Umbilical Cord Stem Cell Research Center (UCSRC), Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Roya
authors.initials: R
authors.lastname: Salehi
authors.affiliation: Research Institute for Fundamental Sciences (RIFS), University of Tabriz, Tabriz, Iran; Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Abolfazl
authors.initials: A
authors.lastname: Barzegar
mesh_terms: D000818:Animals; D040761:Biomimetic Materials / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology*; D002448:Cell Adhesion; D049109:Cell Proliferation / Q000187:drug effects*; D005109:Extracellular Matrix / Q000737:chemistry*; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000378:metabolism*
keywords: Adhesion; Adhesion motifs; Biomimetic polymers; Mesenchymal stem cells; Microenvironment