title: Half-Sandwich Ru(II) Halogenido, Valproato and 4-Phenylbutyrato Complexes Containing 2,2'-Dipyridylamine: Synthesis, Characterization, Solution Chemistry and In Vitro Cytotoxicity.
abstract: Halogenido and carboxylato Ru(II) half-sandwich complexes of the general composition [Ru(η⁶-p-cym)(dpa)X]PF₆ (1-5) were prepared and thoroughly characterized with various techniques (e.g., mass spectrometry, NMR spectroscopy and X-ray analysis); dpa = 2,2'-dipyridylamine;p-cym =p-cymene; X = Cl-(for1), Br-(for2), I-(for3), valproate(1-) (for4) or 4-phenylbutyrate(1-) (for5). A single-crystal X-ray analysis showed a pseudo-octahedral piano-stool geometry of [Ru(η⁶-p-cym)(dpa)I]PF₆ (3), with a η⁶-coordinatedp-cymene, bidentateN-donor dpa ligand and iodido ligand coordinated to the Ru(II) atom. The results of the ¹H-NMR solution behaviour studies proved that the complexes1-5hydrolyse were in the mixture of solvents used (10% MeOD-d₄/90% D₂O). Complexes1-5were in vitro inactive against the A2780 human ovarian carcinoma cell line, up to the highest tested concentration (IC50> 100 μM).
authors.affiliation: Department of Inorganic Chemistry & Regional Centre of Advanced Technologies and Materials, Faculty of Science, Palacký University in Olomouc, 17. listopadu 12, 771 46 Olomouc, Czech Republic. pavel.starha@upol.cz.
authors.forename: Pavel
authors.initials: P
authors.lastname: Štarha
authors.affiliation: Department of Inorganic Chemistry & Regional Centre of Advanced Technologies and Materials, Faculty of Science, Palacký University in Olomouc, 17. listopadu 12, 771 46 Olomouc, Czech Republic. zdenek.travnicek@upol.cz.
authors.forename: Zdeněk
authors.initials: Z
authors.lastname: Trávníček
authors.affiliation: Department of Inorganic Chemistry & Regional Centre of Advanced Technologies and Materials, Faculty of Science, Palacký University in Olomouc, 17. listopadu 12, 771 46 Olomouc, Czech Republic. radka.krikavova@upol.cz.
authors.forename: Radka
authors.initials: R
authors.lastname: Křikavová
authors.affiliation: Department of Cell Biology and Genetics & Regional Centre of Advanced Technologies and Materials, Faculty of Science, Palacký University in Olomouc, Šlechtitelů 27, 783 71 Olomouc, Czech Republic. zdenek.dvorak@upol.cz.
authors.forename: Zdeněk
authors.initials: Z
authors.lastname: Dvořák
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry*; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D015195:Drug Design; D005978:Glutathione / Q000737:chemistry; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy*; D066244:Proton Magnetic Resonance Spectroscopy; D012428:Ruthenium / Q000737:chemistry*; D012997:Solvents / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D012997:Solvents; D012428:Ruthenium; D005978:Glutathione
keywords: 2,2′-dipyridylamine; X-ray structure; half-sandwich; in vitro cytotoxicity; ruthenium; solution behaviour