title: Minimally Invasive Lymphadenectomy in Uterine Cervical Cancer: A Systematic Review.
abstract: The aim of this study was to review the current literature on the role of minimally invasive lymphadenectomy in the treatment of cervical cancer.
  
  
  
  Non-randomized control trials published between January 2007 to May 2016 were identified by searching the Pubmed, EMBASE and Cochrane Library databases. Primary endpoints included operative outcomes (operative time, intraoperative blood loss, number of transfused patients and conversion rates), postoperative outcomes (length of postoperative hospital stay, postoperative morbidity and postoperative in-hospital mortality), and oncological outcomes (number of harvested lymph nodes, tumor recurrence, disease-free rates and overall survival rates).
  
  
  
  A total of 17 studies with a total of 1,676 patients were included in the review. Compared to the open approach, minimally invasive lymphadenectomy demonstrated a significantly larger number of harvested lymph nodes, longer operative time, lower intraoperative blood loss and shorter postoperative hospital stay. No significant differences were observed between groups treated with an open, laparoscopic or robotic approach for the following criteria: lymph node metastasis, postoperative morbidity, tumor recurrence and postoperative mortality.
  
  
  
  Although a technically demanding and time-consuming procedure, minimally invasive lymphadenectomy appears to be safe and feasible and may offer an alternative approach in staging and treatment of cervical cancer. Multicentre randomized controlled trials investigating its long-term oncological outcomes and its cost-effectiveness are required to determine the advantages of this procedure over the open approach in cervical cancer.
authors.affiliation: First Department of Surgery, Laikon General Hospital, Athens, Greece.
authors.forename: Natasa
authors.initials: N
authors.lastname: Rizou
authors.affiliation: Lerner Research Institute, Cleveland Clinic, Cleveland, OH, U.S.A. dimmoris@yahoo.com.
authors.forename: Demetrios
authors.initials: D
authors.lastname: Moris
authors.affiliation: First Department of Surgery, Laikon General Hospital, Athens, Greece.
authors.forename: Emmanouil
authors.initials: E
authors.lastname: Pikoulis
authors.affiliation: First Department of Surgery, Laikon General Hospital, Athens, Greece.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Dimitrokallis
authors.affiliation: First Department of Surgery, Laikon General Hospital, Athens, Greece.
authors.forename: Eustratia
authors.initials: E
authors.lastname: Mpaili
authors.affiliation: First Department of Surgery, Laikon General Hospital, Athens, Greece.
authors.forename: Evangelos
authors.initials: E
authors.lastname: Felekouras
authors.affiliation: First Department of Surgery, Laikon General Hospital, Athens, Greece.
authors.forename: Alexandros
authors.initials: A
authors.lastname: Papalampros
mesh_terms: D005260:Female; D006801:Humans; D010535:Laparoscopy; D008197:Lymph Node Excision; D010388:Pelvis; D012371:Robotics; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000601:surgery*
keywords: Uterine cervical cancer; laparoscopy; lymphadenectomy; robotics