title: Impact of sleep apnea syndrome on survival in patients with multiple system atrophy.
abstract: Sleep apnea is very frequent in multiple system atrophy (MSA) and may contribute to the poor prognosis. The aim of the present study was to prospectively assess the relation between sleep apnea and survival in 30 consecutive MSA patients recruited at the French Reference Center for MSA.
  
  
  
  Patients with "probable" MSA according to current consensus diagnosis criteria were enrolled in this prospective cohort study. All patients received full polysomnography at baseline and were then followed for up to 4.5 years. The prognostic role of sleep apnea was assessed by a Cox model in an univariate analysis and then adjusted on other potential factors.
  
  
  
  Analyzable polysomnographic recordings were available for 28 patients. Sleep apnea was found in 11 patients. During follow-up, 15 patients died, including 9 with baseline sleep apnea. In an univariate analysis, sleep apnea, Unified MSA Rating Scale I + II score at baseline and at year one, and disease duration were associated with mortality. However, when adjusting for disease duration and baseline Unified MSA Rating Scale score, the association between sleep apnea and mortality was no longer significant.
  
  
  
  Sleep apnea was not an independent factor associated with mortality in this prospective cohort study.
authors.affiliation: Service de Neurologie, CHU de Bordeaux, F-33076 Bordeaux, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Flabeau
authors.affiliation: Department of Clinical Neurophysiology, University Hospital Bordeaux, France; CNRS, Institut de Neurosciences Cognitives et Intégratives d'Aquitaine, CNRS UMR 5287, Université de Bordeaux, Bordeaux, France.
authors.forename: Imad
authors.initials: I
authors.lastname: Ghorayeb
authors.affiliation: CHU de Bordeaux, Unité de Soutien Méthodologique à la Recherche Clinique (USMR), Pôle de santé publique, Bordeaux, France.
authors.forename: Paul
authors.initials: P
authors.lastname: Perez
authors.affiliation: CHU de Bordeaux, Unité de Soutien Méthodologique à la Recherche Clinique (USMR), Pôle de santé publique, Bordeaux, France.
authors.forename: Aline
authors.initials: A
authors.lastname: Maillard
authors.affiliation: Univ. Bordeaux, Sommeil, Attention et Neuropsychiatrie, USR 3413, F-33000 Bordeaux, France; CNRS, Sommeil, Attention et Neuropsychiatrie, USR 3413, F-33000 Bordeaux, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Taillard
authors.affiliation: Univ. Bordeaux, Sommeil, Attention et Neuropsychiatrie, USR 3413, F-33000 Bordeaux, France; CNRS, Sommeil, Attention et Neuropsychiatrie, USR 3413, F-33000 Bordeaux, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Philip
authors.affiliation: Service de Neurologie, CHU de Bordeaux, F-33076 Bordeaux, France; Univ. de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France; CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France; Centre de référence atrophie multisystématisée, CHU de Bordeaux, F-33076 Bordeaux, France.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Foubert-Samier
authors.affiliation: Service de Neurologie, CHU de Bordeaux, F-33076 Bordeaux, France; Univ. de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France; CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France; Centre de référence atrophie multisystématisée, CHU de Bordeaux, F-33076 Bordeaux, France.
authors.forename: François
authors.initials: F
authors.lastname: Tison
authors.affiliation: Service de Neurologie, CHU de Bordeaux, F-33076 Bordeaux, France; Univ. de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France; CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France; Centre de référence atrophie multisystématisée, CHU de Bordeaux, F-33076 Bordeaux, France. Electronic address: wassilios.meissner@chu-bordeaux.fr.
authors.forename: Wassilios G
authors.initials: WG
authors.lastname: Meissner
mesh_terms: D000368:Aged; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000175:diagnosis* / Q000401:mortality* / Q000503:physiopathology; D017286:Polysomnography / Q000639:trends; D011446:Prospective Studies; D012891:Sleep Apnea Syndromes / Q000175:diagnosis* / Q000401:mortality* / Q000503:physiopathology; D015996:Survival Rate / Q000639:trends
keywords: MSA; Polysomnography; Sleep apnea