title: Parkin and PINK1 functions in oxidative stress and neurodegeneration.
abstract: Loss-of-function mutations in the genes encoding Parkin and PINK1 are causally linked to autosomal recessive Parkinson's disease (PD). Parkin, an E3 ubiquitin ligase, and PINK1, a mitochondrial-targeted kinase, function together in a common pathway to remove dysfunctional mitochondria by autophagy. Presumably, deficiency for Parkin or PINK1 impairs mitochondrial autophagy and thereby increases oxidative stress due to the accumulation of dysfunctional mitochondria that release reactive oxygen species. Parkin and PINK1 likely have additional functions that may be relevant to the mechanisms by which mutations in these genes cause neurodegeneration, such as regulating inflammation, apoptosis, or dendritic morphogenesis. Here we briefly review what is known about functions of Parkin and PINK1 related to oxidative stress and neurodegeneration.
authors.affiliation: Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, The University of Alabama at Birmingham, Birmingham, AL 35294, United States.
authors.forename: Sandeep K
authors.initials: SK
authors.lastname: Barodia
authors.affiliation: Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, The University of Alabama at Birmingham, Birmingham, AL 35294, United States.
authors.forename: Rose B
authors.initials: RB
authors.lastname: Creed
authors.affiliation: Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, The University of Alabama at Birmingham, Birmingham, AL 35294, United States; Department of Neurobiology, The University of Alabama at Birmingham, Birmingham, AL 35294, United States. Electronic address: mattgoldberg@uab.edu.
authors.forename: Matthew S
authors.initials: MS
authors.lastname: Goldberg
mesh_terms: D000818:Animals; D001343:Autophagy / Q000235:genetics; D006801:Humans; D008928:Mitochondria / Q000378:metabolism; D009154:Mutation / Q000235:genetics; D019636:Neurodegenerative Diseases / Q000235:genetics; D018384:Oxidative Stress / Q000235:genetics / Q000502:physiology; D010300:Parkinson Disease / Q000235:genetics* / Q000378:metabolism; D011494:Protein Kinases / Q000235:genetics* / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D044767:Ubiquitin-Protein Ligases / Q000235:genetics* / Q000378:metabolism; D000099202:PTEN-Induced Putative Kinase
chemical_list: D011494:Protein Kinases; D017382:Reactive Oxygen Species; D044767:Ubiquitin-Protein Ligases; D000099202:PTEN-Induced Putative Kinase; C111567:parkin protein
keywords: Mitophagy; Neurodegeneration; Oxidative stress; PINK1; Parkin; Ubiquitin