title: Development and Structural Modification of BACE1 Inhibitors.
abstract: Alzheimer's disease (AD) is a progressive neurodegenerative disorder which usually occurs in the elderly. The accumulation of β-amyloid and the formation of neurofibrillary tangles are considered as the main pathogenies of AD. Research suggests that β-secretase 1 (BACE1) plays an important role in the formation of β-amyloid. Discovery of new BACE1 inhibitors has become a significant method to slow down the progression of AD or even cure this kind of disease. This review summarizes the different types and the structural modification of these new BACE1 inhibitors.
authors.affiliation: Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, China. guting1992@163.com.
authors.forename: Ting
authors.initials: T
authors.lastname: Gu
authors.affiliation: Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, China. 15150513147@163.com.
authors.forename: Wen-Yu
authors.initials: WY
authors.lastname: Wu
authors.affiliation: Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, China. dongzexi1215@163.com.
authors.forename: Ze-Xi
authors.initials: ZX
authors.lastname: Dong
authors.affiliation: Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, China. yushaopeng0405@163.com.
authors.forename: Shao-Peng
authors.initials: SP
authors.lastname: Yu
authors.affiliation: Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, China. 18260028601@163.com.
authors.forename: Ying
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, China. 18260028701@163.com.
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhong
authors.affiliation: Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, China. lyt1996tian@outlook.com.
authors.forename: Yu-Ting
authors.initials: YT
authors.lastname: Lu
authors.affiliation: Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, China. linianguang@njutcm.edu.cn.
authors.forename: Nian-Guang
authors.initials: NG
authors.lastname: Li
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis / Q000494:pharmacology; D000544:Alzheimer Disease / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D053829:Amyloid Precursor Protein Secretases / Q000037:antagonists & inhibitors* / Q000096:biosynthesis / Q000235:genetics; D016229:Amyloid beta-Peptides / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000235:genetics; D001224:Aspartic Acid / Q000737:chemistry / Q000378:metabolism; D016282:Aspartic Acid Endopeptidases / Q000037:antagonists & inhibitors* / Q000096:biosynthesis / Q000235:genetics; D003474:Curcumin / Q000138:chemical synthesis / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D015870:Gene Expression; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D018696:Neuroprotective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D057786:Peptidomimetics / Q000138:chemical synthesis* / Q000494:pharmacology; D010879:Piperazines / Q000138:chemical synthesis / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013729:Terpenes / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D000470:Alkaloids; D016229:Amyloid beta-Peptides; D004791:Enzyme Inhibitors; D018696:Neuroprotective Agents; D057786:Peptidomimetics; D010879:Piperazines; D013729:Terpenes; D001224:Aspartic Acid; D053829:Amyloid Precursor Protein Secretases; D016282:Aspartic Acid Endopeptidases; C509280:BACE1 protein, human; D003474:Curcumin
keywords: Alzheimer’s disease; BACE1; BACE1 inhibitors; structural modification; β-amyloid