title: Dietary Supplement Use in Older People Attending Memory Clinics in Australia.
abstract: Dietary supplement use is common in older adults. There has been limited research in people attending memory clinics.
  
  
  
  To explore the use of dietary supplements in older people attending Australian memory clinics.
  
  
  
  Cross-sectional analysis of baseline data from the Prospective Research In MEmory clinics (PRIME) study.
  
  
  
  Community-dwelling older people who attended nine memory clinics and had a diagnosis of mild cognitive impairment (MCI) or dementia.
  
  
  
  Dietary supplement was defined as a product that contains one or more: vitamin, mineral, herb or other botanical, amino acid or other dietary substance. Non-prescribed supplement was defined as a supplement that is not usually prescribed by a medical practitioner. Polypharmacy was defined as use of five or more medications.
  
  
  
  964 patients, mean age 77.6 years, were included. Dietary supplements were used by 550 (57.1%) patients; 353 (36.6%) used two or more. Non-prescribed supplements were used by 364 (36.8%) patients. Supplement use was associated with older age (OR: 1.12, 95% CI: 1.03-1.21), lower education level (OR: 1.53, 95% CI: 1.01-2.32) and a diagnosis of MCI rather than dementia (OR: 1.52, 95% CI: 1.05-2.21). Potential drug-supplement interactions were identified in 107 (11.1%) patients. Supplement users had increased prevalence of polypharmacy compared to non-users (80.5% vs. 48.1%, p<0.001).
  
  
  
  Dietary supplements, including non-prescribed supplements, were commonly used by people attending memory clinics. Supplement use increased the prevalence of polypharmacy and resulted in potential supplement-drug interactions. Further research is required to assess the clinical outcomes of supplement use.
authors.affiliation: Rohan A Elliott. Pharmacy Department, Austin Health, PO Box 5555, Heidelberg, VIC, 3084, Australia. Phone: +61 3 9496 2334. Fax: +61 3 9496 5900, Email: rohan.elliott@austin.org.au.
authors.forename: A J
authors.initials: AJ
authors.lastname: Cross
authors.forename: J
authors.initials: J
authors.lastname: George
authors.forename: M C
authors.initials: MC
authors.lastname: Woodward
authors.forename: D
authors.initials: D
authors.lastname: Ames
authors.forename: H
authors.initials: H
authors.lastname: Brodaty
authors.forename: R A
authors.initials: RA
authors.lastname: Elliott
mesh_terms: D000368:Aged; D001315:Australia; D003072:Cognition Disorders / Q000175:diagnosis / Q000188:drug therapy; D003430:Cross-Sectional Studies; D003704:Dementia / Q000175:diagnosis / Q000188:drug therapy; D019587:Dietary Supplements; D006801:Humans; D016015:Logistic Models; D008568:Memory / Q000187:drug effects*; D015999:Multivariate Analysis; D019338:Polypharmacy; D014131:Trace Elements / Q000008:administration & dosage; D014815:Vitamins / Q000008:administration & dosage
chemical_list: D014131:Trace Elements; D014815:Vitamins