title: Relative contributions of testosterone deficiency and metabolism syndrome at the risk of reduced quality of life: A cross-sectional study among Chinese mid-aged and elderly men.
abstract: Testosterone deficiency and metabolism syndrome (MetS) are universal among ageing males, and they have been suggested responsible for poorer quality of life (QoL). We aimed to evaluate the relative contributions of reproductive hormones and components of MetS at the risk of reduced QoL among Chinese mid-aged and elderly men. A cross-sectional study recruited 2,364 males aged 40-79 years, and 2,165 was included for analysis eventually. The Chinese version of ageing male symptoms scale, 36-item Short Form and Beck Depression Inventory were applied to assess QoL. Bivariate correlation analysis and multiple linear regression analysis were used to assess the relative contributions of reproductive hormones and components of MetS at the risk of reduced QoL. Testosterone deficiency and MetS contributed to poorer QoL, of which higher fasting blood glucose made the primary contribution, lower total testosterone mainly contributed to poorer physical functioning.
authors.affiliation: Department of Andrology, Jingling Hospital, School of Medicine, Nanjing University, Nanjing, China.|Family Planning Research Institute/Center of Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: X R
authors.initials: XR
authors.lastname: Qing
authors.affiliation: Clinical laboratory, People's hospital of Jinhu County, Huai'an, China.
authors.forename: C C
authors.initials: CC
authors.lastname: Wan
authors.affiliation: Department of Andrology, Jingling Hospital, School of Medicine, Nanjing University, Nanjing, China.
authors.forename: X J
authors.initials: XJ
authors.lastname: Shang
authors.affiliation: Family Planning Research Institute/Center of Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: H G
authors.initials: HG
authors.lastname: Li
authors.affiliation: Family Planning Research Institute/Center of Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: C L
authors.initials: CL
authors.lastname: Xiong
authors.affiliation: Center of Reproductive Medicine, Xi'an No. 4 hospital/GuangRen hospital of Xi'an Jiaotong University, Xi'an, China.
authors.forename: X X
authors.initials: XX
authors.lastname: Zhan
authors.affiliation: Department of Andrology, Jingling Hospital, School of Medicine, Nanjing University, Nanjing, China.
authors.forename: D S
authors.initials: DS
authors.lastname: Mo
authors.affiliation: Department of Andrology, Jingling Hospital, School of Medicine, Nanjing University, Nanjing, China.
authors.forename: H C
authors.initials: HC
authors.lastname: Cai
authors.affiliation: Family Planning Research Institute/Center of Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: H P
authors.initials: HP
authors.lastname: Zhang
authors.affiliation: Family Planning Research Institute/Center of Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: H T
authors.initials: HT
authors.lastname: Guan
authors.affiliation: Center of Reproductive Medicine, The first affiliated hospital of Wenzhou Medical University, Wenzhou, China.
authors.forename: X B
authors.initials: XB
authors.lastname: Kong
authors.affiliation: Family Planning Research Institute/Center of Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Y P
authors.initials: YP
authors.lastname: Chen
authors.affiliation: Family Planning Research Institute/Center of Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: T H
authors.initials: TH
authors.lastname: Liu
authors.affiliation: Department of Urology, People's hospital of Jinhu County, Huai'an, China.
authors.forename: B J
authors.initials: BJ
authors.lastname: Hao
authors.affiliation: Clinical laboratory, People's hospital of Jinhu County, Huai'an, China.
authors.forename: S Y
authors.initials: SY
authors.lastname: Zong
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D003430:Cross-Sectional Studies; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications* / Q000523:psychology; D008875:Middle Aged; D011788:Quality of Life; D013739:Testosterone / Q000172:deficiency*
chemical_list: D013739:Testosterone
keywords: Chinese male; metabolism syndrome; quality of life; relative contribution; testosterone deficiency