title: In VitroCharacterization of Human Mesenchymal Stem Cells Isolated from Different Tissues with a Potential to Promote Complex Bone Regeneration.
abstract: Bone tissue regeneration is a major, worldwide medical need, and several strategies have been developed to support the regeneration of extensive bone defects, including stem cell based bone grafts. In addition to the application of stem cells with high osteogenic potential, it is important to maintain proper blood flow in a bone graft to avoid inner graft necrosis. Mesenchymal stem cells (MSCs) may form both osteocytes and endothelial cells; therefore we examined the combinedin vitroosteogenic and endothelial differentiation capacities of MSCs derived from adipose tissue, Wharton's jelly, and periodontal ligament. Based on a detailed characterization presented here, MSCs isolated from adipose tissue and periodontal ligament may be most appropriate for generating vascularized bone grafts.
authors.affiliation: Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary; Creative Cell Ltd., Budapest, Hungary.
authors.forename: Áron
authors.identifier: 0000-0002-1662-4083
authors.initials: Á
authors.lastname: Szepesi
authors.affiliation: Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary.
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Matula
authors.affiliation: Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary; Creative Cell Ltd., Budapest, Hungary.
authors.forename: Anna
authors.initials: A
authors.lastname: Szigeti
authors.affiliation: Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary.
authors.forename: György
authors.initials: G
authors.lastname: Várady
authors.affiliation: Department of Dentistry, Oral and Maxillofacial Surgery, University of Pécs Medical School, Pécs, Hungary.
authors.forename: József
authors.initials: J
authors.lastname: Szalma
authors.affiliation: Department of Dentistry, Oral and Maxillofacial Surgery, University of Pécs Medical School, Pécs, Hungary.
authors.forename: Gyula
authors.initials: G
authors.lastname: Szabó
authors.affiliation: National Blood Service, Budapest, Hungary.
authors.forename: Ferenc
authors.initials: F
authors.lastname: Uher
authors.affiliation: Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary; Molecular Biophysics Research Group of the Hungarian Academy of Sciences, Semmelweis University, Budapest, Hungary.
authors.forename: Balázs
authors.initials: B
authors.lastname: Sarkadi
authors.affiliation: Creative Cell Ltd., Budapest, Hungary.
authors.forename: Katalin
authors.initials: K
authors.lastname: Német