title: Evaluation of JC and Cytomegalo Viruses in Glioblastoma Tissue
abstract: Glioblastoma multiforme (GBM) is the most aggressive of the gliomas, a collection of tumors arising from glia
  in the central nervous system. Possible associations between the human cytomegalovirus (HCMV) and the JC virus
  with GBM are now attracting interest. Our present aim was to investigate the prevalence of the two viruses in Iranian
  patients from Kerman’s cities in the south of Iran. In addition, the expression rates of pp65, large T antigen and p53
  proteins were assessed and their relation with GBM evaluated using reverse transcription real time PCR (rReal Time
  PCR) . A total of 199 patients with GBM cancer were enrolled, with mean±SD ages of 50.0±19.5 and 50.7±19.6 years
  for males and females, respectively. The P53 rate was dramatically low suggesting an aetiological role,. Large T antigen
  expression was found in JC positive samples, while the PP65 antigen was observed in patients positive for CMV and
  JC . HCMV products and JC virus with oncogenic potential may induce the development of various tumors including
  glioblastomas. The JC virus produces an early gene product, T-antigen, which has the ability to associate with and
  functionally inactivate well-studied tumor suppressor proteins including p53 and pRB .
authors.affiliation: Research Center for Tropical and Infectious Disease, Kerman University of Medical Sciences, Kerman, Iran. Email: hamid2008kmu@gmail.com
authors.forename: Reza
authors.initials: R
authors.lastname: Malekpour Afshar
authors.forename: Hamid Reza
authors.initials: HR
authors.lastname: Mollaei
authors.forename: Bahare
authors.initials: B
authors.lastname: Zandi
authors.forename: Maryam
authors.initials: M
authors.lastname: Iranpour
keywords: Glioblastoma; HCMV; JC Virus; P53; large T Antigen