title: The relationship between MRI quantitative parameters and the expression of hypoxia inducible factor-1 alpha in cerebral astrocytoma.
abstract: OBJECTIVE
  Astrocytoma is the common type of glioma. But the MRI scanning for astrocytoma preoperation pathological diagnosis is not exact. The purpose of this study was to use the MRI multi quantitative parameters to improve the diagnosis of astrocytoma and exploit their molecular mechanism related to the expression of HIF-1α.
  
  
  METHODS
  Superconducting MR scanner and its work station were used to calculate the MRI multi quantitative parameters of the selected patients in this experiment. Scion Image Beta4.03 software was used to get the cellular density of tumor tissue. The expression of HIF-1α in astrocytoma specimens was detected by immunohistochemistry method. The correlation of MRI multi quantitative parameters and the expression of HIF-1α was analyzed by statistical software.
  
  
  RESULTS
  The values of ADC, RSIGd, EP, EI, cellular density and the expression of HIF-1α were changed with the malignant degree of astrocytoma to some extent, but not every quantitative parameter was related to the expression of HIF-1α.
  
  
  CONCLUSIONS
  The MRI multi quantitative parameters binding with conventional MRI imaging can significantly raise the diagnostic accuracy of astrocytoma preoperatively. MRI features could indirectly reflect the biological behavior of astrocytoma. The peritumoral edema can't be explained by only one theory.
authors.affiliation: Medical College of Nankai University, Tianjin, 300071, China. Electronic address: klyyshch@sina.com.
authors.forename: Chang
authors.initials: C
authors.lastname: Shu
authors.affiliation: Medical College of Nankai University, Tianjin, 300071, China; Department of Neurosurgery, Tianjin Huan Hu Hospital, Tianjin, 300060, China. Electronic address: wangjinhuanfch@163.com.
authors.forename: Jinhuan
authors.initials: J
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001254:Astrocytoma / Q000000981:diagnostic imaging* / Q000378:metabolism*; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism*; D005260:Female; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000378:metabolism*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D051795:Hypoxia-Inducible Factor 1, alpha Subunit
keywords: Astrocytoma; Cellular density; Diffusion-weighted imaging; Hypoxia inducible factor-α; Magnetic resonance imaging; Peritumoral edema