title: Region-based diffuse optical tomography with registered atlas:in vivoacquisition of mouse optical properties.
abstract: The reconstruction quality in the model-based optical tomography modalities can greatly benefit froma prioriinformation of accurate tissue optical properties, which are difficult to be obtainedin vivowith a conventional diffuse optical tomography (DOT) system alone. One of the solutions is to applya priorianatomical structures obtained with anatomical imaging systems such as X-ray computed tomography (XCT) to constrain the reconstruction process of DOT. However, since X-ray offers low soft-tissue contrast, segmentation of abdominal organs from sole XCT images can be problematic. In order to overcome the challenges, the current study proposes a novel method of recoveringa prioriorgan-oriented tissue optical properties, where anatomical structures of anin vivomouse are approximately obtained by registering a standard anatomical atlas,i.e., the Digimouse, to the target XCT volume with the non-rigid image registration, and, in turn, employed to guide DOT for extracting the optical properties of inner organs. Simulative investigations have validated the methodological availability of such atlas-registration-based DOT strategy in revealing botha priorianatomical structures and optical properties. Further experiments have demonstrated the feasibility of the proposed method for acquiring the organ-oriented tissue optical properties ofin vivomice, making it as an efficient way of the reconstruction enhancement.
authors.affiliation: College of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China.
authors.forename: Wenbo
authors.initials: W
authors.lastname: Wan
authors.affiliation: College of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China.
authors.forename: Yihan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: College of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China; Cancer Institute and Hospital, Tianjin Medical University, Tianjin 300060, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Qi
authors.affiliation: College of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China.
authors.forename: Lingling
authors.initials: L
authors.lastname: Liu
authors.affiliation: Cancer Institute and Hospital, Tianjin Medical University, Tianjin 300060, China.
authors.forename: Wenjuan
authors.initials: W
authors.lastname: Ma
authors.affiliation: College of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China; Tianjin Key Laboratory of Biomedical Detecting Techniques and Instruments, Tianjin 300072, China.
authors.forename: Jiao
authors.initials: J
authors.lastname: Li
authors.affiliation: College of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China; Tianjin Key Laboratory of Biomedical Detecting Techniques and Instruments, Tianjin 300072, China.
authors.forename: Limin
authors.initials: L
authors.lastname: Zhang
authors.affiliation: College of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China; Tianjin Key Laboratory of Biomedical Detecting Techniques and Instruments, Tianjin 300072, China.
authors.forename: Zhongxing
authors.initials: Z
authors.lastname: Zhou
authors.affiliation: College of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China; Tianjin Key Laboratory of Biomedical Detecting Techniques and Instruments, Tianjin 300072, China.
authors.forename: Huijuan
authors.initials: H
authors.lastname: Zhao
authors.affiliation: College of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China; Tianjin Key Laboratory of Biomedical Detecting Techniques and Instruments, Tianjin 300072, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Gao
keywords: (110.2960) Image analysis; (170.3010) Image reconstruction techniques; (170.3880) Medical and biological imaging; (170.6960) Tomography