title: Y chromothripsis?
abstract: Micronucleation of missegregated chromatin can lead to substantial chromosome rearrangements via chromothripsis. However, the molecular details of micronucleus-based chromothripsis are still unclear. Now, an elegant system that specifically induces missegregation of the Y chromosome provides insight into this process, including a role for non-homologous end joining.
authors.affiliation: Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N., Seattle, Washington 98109, USA.
authors.forename: Emily M
authors.initials: EM
authors.lastname: Hatch
mesh_terms: D002843:Chromatin / Q000378:metabolism; D041322:Chromosomes, Human, Y / Q000378:metabolism*; D000072837:Chromothripsis; D059766:DNA End-Joining Repair; D006801:Humans; D048629:Micronuclei, Chromosome-Defective; D008954:Models, Biological
chemical_list: D002843:Chromatin