title: β-Dihydroagarofuran-Type Sesquiterpenes from the Seeds of Celastrus monospermus and Their Lifespan-Extending Effects on the Nematode Caenorhabditis elegans.
abstract: Seventeen β-dihydroagarofuran-type sesquiterpenes were isolated from the seeds of Celastrus monospermus, and, among them, 15 (1-15) were identified as new natural products. Nine isolates were evaluated for their lifespan-extending effect using the standard model animal nematode Caenorhabditis elegans. As a result, all of the tested compounds prolonged the lifespan of C. elegans when compared to the blank control group (p < 0.0001). Among them, celaspermin E (5) extended the average lifespan and maximum lifespan of C. elegans, with effects similar to those of rapamycin, a positive control that has been found experimentally to delay the aging process of yeasts, worms, fruit flies, and mice.
authors.affiliation: Department of Natural Product Chemistry and State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203, People's Republic of China.|University of Chinese Academy of Sciences , Beijing 100049, People's Republic of China.
authors.forename: Lei
authors.initials: L
authors.lastname: Gao
authors.affiliation: Department of Natural Product Chemistry and State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203, People's Republic of China.
authors.forename: Rujun
authors.initials: R
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animals for Disease Study, Model Animal Research Center, Nanjing University , Nanjing 210061, People's Republic of China.
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Lan
authors.affiliation: Department of Natural Product Chemistry and State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203, People's Republic of China.|University of Chinese Academy of Sciences , Beijing 100049, People's Republic of China.
authors.forename: Ruonan
authors.initials: R
authors.lastname: Ning
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animals for Disease Study, Model Animal Research Center, Nanjing University , Nanjing 210061, People's Republic of China.
authors.forename: Di
authors.initials: D
authors.lastname: Wu
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animals for Disease Study, Model Animal Research Center, Nanjing University , Nanjing 210061, People's Republic of China.
authors.forename: Di
authors.initials: D
authors.lastname: Chen
authors.affiliation: Department of Natural Product Chemistry and State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203, People's Republic of China.
authors.forename: Weimin
authors.identifier: http://orcid.org/0000-0001-8879-069X
authors.initials: W
authors.lastname: Zhao
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000187:drug effects*; D031247:Celastrus / Q000737:chemistry*; D008136:Longevity / Q000187:drug effects; D015394:Molecular Structure; D012639:Seeds / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D012717:Sesquiterpenes; C079978:dihydroagarofuran