title: Objective Predictive Score as a Feasible Biomarker for Short-term Survival in TerminalIy Ill Patients with Cancer.
abstract: In palliative care, prediction of life expectancy is one of the most crucial issues for patients, family and medical staff, in order to provide appropriate end-of-life care. The aim of this study was to formulate a new objective score to predict life expectancy within 1 week for terminally ill patients with cancer.
  
  
  
  Medical records were obtained from 187 terminally-ill patients with cancer who were admitted for palliative care. The biomarkers for a potential 'Objective Predictive Score' were assessed.
  
  
  
  Profiling of blood parameters demonstrated that elevated levels of alanine aminotransferase (ALT), total bilirubin (T-bil), blood urea nitrogen (BUN), creatinine (Cr) and a decreased platelet count were significantly correlated with death within 1 week in a training cohort. Our formulated Objective Predictive Score was able to predict death within 1 week with high accuracy in a training and a validation cohort.
  
  
  
  Our scoring system might enable the assessment of prognostication with higher accuracy in a terminal care setting.
authors.affiliation: Department of Surgery, Iga City General Hospital, Mie, Japan yoshinaga.okugawa@gmail.com harborne3030@gmail.com.|Department of Medical Oncology, Iga City General Hospital, Mie, Japan.|Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Mie, Japan.
authors.forename: Yoshinaga
authors.initials: Y
authors.lastname: Okugawa
authors.affiliation: Department of Nutrition, Iga City General Hospital, Mie, Japan.
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Shirai
authors.affiliation: Department of Nursing, Iga City General Hospital, Mie, Japan.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Nodono
authors.affiliation: Department of Nursing, Iga City General Hospital, Mie, Japan.
authors.forename: Fukumi
authors.initials: F
authors.lastname: Matsutani
authors.affiliation: Department of Nursing, Iga City General Hospital, Mie, Japan.
authors.forename: Mari
authors.initials: M
authors.lastname: Itoh
authors.affiliation: Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Asahi
authors.initials: A
authors.lastname: Hishida
authors.affiliation: Department of Medical Oncology, Iga City General Hospital, Mie, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Morimoto
authors.affiliation: Department of Medical Oncology, Iga City General Hospital, Mie, Japan.
authors.forename: Ryutaro
authors.initials: R
authors.lastname: Nishikawa
authors.affiliation: Department of Medical Oncology, Iga City General Hospital, Mie, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yokoe
authors.affiliation: Department of Medical Oncology, Iga City General Hospital, Mie, Japan.|Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Mie, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Tanaka
authors.affiliation: Department of Medical Oncology, Iga City General Hospital, Mie, Japan.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Urata
authors.affiliation: Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Mie, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Toiyama
authors.affiliation: Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Mie, Japan.
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Araki
authors.affiliation: Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Mie, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Inoue
authors.affiliation: Department of Medical Oncology, Iga City General Hospital, Mie, Japan.
authors.forename: Motoyoshi
authors.initials: M
authors.lastname: Tanaka
authors.affiliation: Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Mie, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Kusunoki
authors.affiliation: Department of Surgery, Iga City General Hospital, Mie, Japan yoshinaga.okugawa@gmail.com harborne3030@gmail.com.
authors.forename: Chikao
authors.initials: C
authors.lastname: Miki
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000410:Alanine Transaminase / Q000097:blood; D001663:Bilirubin; D015415:Biomarkers / Q000097:blood; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D008017:Life Expectancy; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood* / Q000628:therapy; D010166:Palliative Care; D010976:Platelet Count; D011379:Prognosis; D016016:Proportional Hazards Models; D012720:Severity of Illness Index; D013727:Terminal Care; D019452:Terminally Ill
chemical_list: D015415:Biomarkers; D003404:Creatinine; D000410:Alanine Transaminase; D001663:Bilirubin
keywords: Palliative care; advanced cancer; objective predictive scoring system; predictive biomarker; prognosis