title: A prospective intra-individual evaluation of silk compared to Biobrane for the treatment of superficial burns of the hand and face.
abstract: BACKGROUND
  An ever-increasing number of commercially available dressings have been applied to treat superficial burns with the aim to reduce pain and inflammation and lead to a fast wound healing and scar reduction. Nevertheless the search for cheap and effective wound dressing proceeds. Dressilk®consisting of silkworm silk showed good results for wound healing in regards to scarring, biocompatibility and reduction of inflammation and pain. Therefore it seemed to be an interesting product for the treatment of superficial burns.
  
  
  METHODS
  In a prospective intra-individual study the healing of superficial burns was evaluated after the treatment with Dressilk®and Biobrane®in 30 patients with burns of the hand and face. During wound healing pain, active bleeding, exudation, dressing change and inflammation were evaluated using the Verbal Rating Scale 1-10. Three months later scar appearance was assessed by VSS (Vancouver Scar Scale) and POSAS (Patient and Observer Scar Scale).
  
  
  RESULTS
  With regard to re-epithelialization, pain, inflammation and acute bleeding both dressings were equivalent. High subjective satisfaction rates were reported for both Dressilk®and Biobrane®dressings in regard to comfort and mobility of the face. Biobrane®, applied as a glove was subjectively preferred for burns of the hand. Regarding their cost efficiency Dressilk®was clearly superior to Biobrane®. Long-term results were similar.
  
  
  CONCLUSIONS
  The "ideal" wound dressing maximizes patients' comfort while reducing pain and promoting wound healing. Dressilk®and Biobrane®both provided an effective and safe healing environment, showing low overall complication rates with respect to infection and exudation on superficial burns of the hand and face. Therefore Dressilk®, being clearly superior to Biobrane®in cost efficiency is an interesting alternative especially for the treatment of superficial burns of faces.
authors.affiliation: Clinic of Plastic, Reconstructive, Hand and Burn Surgery, Hospital Cologne Merheim, University of Witten-Herdecke, Germany. Electronic address: schiefer.jennifer@gmail.com.
authors.forename: Jennifer Lynn
authors.initials: JL
authors.lastname: Schiefer
authors.affiliation: Clinic of Plastic, Reconstructive, Hand and Burn Surgery, Hospital Cologne Merheim, University of Witten-Herdecke, Germany.
authors.forename: Elena
authors.initials: E
authors.lastname: Arens
authors.affiliation: Clinic of Anesthesiology at the University Hospital Bonn, Germany.
authors.forename: Daniel
authors.initials: D
authors.lastname: Grigutsch
authors.affiliation: Clinic of General, Thorax and Transplantation Surgery, Katharinenhospital Stuttgart, Germany.
authors.forename: Rebekka
authors.initials: R
authors.lastname: Rath
authors.affiliation: Clinic of Plastic, Reconstructive, Hand and Burn Surgery, Hospital Cologne Merheim, University of Witten-Herdecke, Germany.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Hoffmann
authors.affiliation: Clinic of Plastic, Reconstructive, Hand and Burn Surgery, Hospital Cologne Merheim, University of Witten-Herdecke, Germany.
authors.forename: Paul Christian
authors.initials: PC
authors.lastname: Fuchs
authors.affiliation: Clinic of Plastic, Reconstructive, Hand and Burn Surgery, Hospital Cologne Merheim, University of Witten-Herdecke, Germany.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Schulz
mesh_terms: D000328:Adult; D001458:Bandages; D002056:Burns / Q000150:complications / Q000628:therapy*; D002921:Cicatrix / Q000209:etiology; D020099:Coated Materials, Biocompatible / Q000191:economics / Q000627:therapeutic use*; D003362:Cost-Benefit Analysis; D005122:Exudates and Transudates; D005151:Facial Injuries / Q000150:complications / Q000628:therapy*; D006230:Hand Injuries / Q000150:complications / Q000628:therapy*; D006470:Hemorrhage; D006801:Humans; D007249:Inflammation; D008297:Male; D008875:Middle Aged; D010146:Pain; D011446:Prospective Studies; D062326:Re-Epithelialization; D047011:Silk / Q000191:economics / Q000627:therapeutic use*; D014945:Wound Healing; D055815:Young Adult
chemical_list: C042816:Biobrane; D020099:Coated Materials, Biocompatible; D047011:Silk
keywords: Biobrane; Dressilk; Facial burns; Hand burns; Silk; Superficial burns