title: Cognitive deficits in non-demented diabetic elderly appear independent of brain amyloidosis.
abstract: BACKGROUND
  To determine the effects of Type 2 diabetes (DM2) on levels of brain amyloidosis and cognition in a community-dwelling cohort of nondemented elderly individuals.
  
  
  METHODS
  33 subjects (16 DM2, 17 nondiabetic) were prospectively recruited. Subjects underwent a PET scan using the amyloid tracer, Pittsburgh Compound B, and a neuropsychological evaluation. Associations between DM2, brain amyloidosis, and cognition were assessed using multivariate regressions, adjusting for age and APOE4 status.
  
  
  RESULTS
  DM2 subjects had lower global cognitive function (p=0.018), as measured by the Repeatable Battery for the Assessment of Neuropsychological Status. There was no difference in brain amyloidosis between groups (p=0.25).
  
  
  CONCLUSIONS
  Community-dwelling, nondemented individuals with DM2 had greater cognitive deficits, which do not appear to be mediated by brain amyloidosis. Further studies exploring potential mediators of these cognitive deficits should be performed.
authors.affiliation: Department of Radiology, Division of Neuroradiology, Weill Cornell Medical College, NewYork-Presbyterian Hospital, New York, NY, United States. Electronic address: gcc9004@med.cornell.edu.
authors.forename: Gloria C
authors.initials: GC
authors.lastname: Chiang
authors.affiliation: Department of Radiology, Division of Neuroradiology, Weill Cornell Medical College, NewYork-Presbyterian Hospital, New York, NY, United States.
authors.forename: Eileen
authors.initials: E
authors.lastname: Chang
authors.affiliation: Department of Radiology, Division of Neuroradiology, Weill Cornell Medical College, NewYork-Presbyterian Hospital, New York, NY, United States.
authors.forename: Sneha
authors.initials: S
authors.lastname: Pandya
authors.affiliation: Department of Radiology, Division of Neuroradiology, Weill Cornell Medical College, NewYork-Presbyterian Hospital, New York, NY, United States.
authors.forename: Amy
authors.initials: A
authors.lastname: Kuceyeski
authors.affiliation: Department of Radiology, Division of Neuroradiology, Weill Cornell Medical College, NewYork-Presbyterian Hospital, New York, NY, United States.
authors.forename: James
authors.initials: J
authors.lastname: Hu
authors.affiliation: Department of Neurology, Weill Cornell Medical College, NewYork-Presbyterian Hospital, New York, NY, United States.
authors.forename: Richard
authors.initials: R
authors.lastname: Isaacson
authors.affiliation: Department of Nursing, Hunter-Bellevue School of Nursing, New York, NY, United States.
authors.forename: Christine
authors.initials: C
authors.lastname: Ganzer
authors.affiliation: Department of Medicine, Division of Endocrinology, Weill Cornell Medical College, NewYork-Presbyterian Hospital, New York, NY, United States.
authors.forename: Aaron
authors.initials: A
authors.lastname: Schulman
authors.affiliation: Department of Medicine, Division of Endocrinology, Weill Cornell Medical College, NewYork-Presbyterian Hospital, New York, NY, United States.
authors.forename: Vivian
authors.initials: V
authors.lastname: Sobel
authors.affiliation: Department of Radiology, Division of Neuroradiology, Weill Cornell Medical College, NewYork-Presbyterian Hospital, New York, NY, United States.
authors.forename: Shankar
authors.initials: S
authors.lastname: Vallabhajosula
authors.affiliation: Department of Neurology, Weill Cornell Medical College, NewYork-Presbyterian Hospital, New York, NY, United States.
authors.forename: Lisa
authors.initials: L
authors.lastname: Ravdin
mesh_terms: D000368:Aged; D000686:Amyloidosis / Q000150:complications* / Q000000981:diagnostic imaging*; D000814:Aniline Compounds / Q000378:metabolism; D001921:Brain / Q000000981:diagnostic imaging*; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000209:etiology*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005260:Female; D006801:Humans; D057187:Independent Living; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D049268:Positron-Emission Tomography; D013844:Thiazoles / Q000378:metabolism
chemical_list: C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D000814:Aniline Compounds; D013844:Thiazoles
keywords: Beta-amyloid; Cognition; Positron emission tomography; Type 2 diabetes