title: Topical imiquimod clears invasive melanoma.
abstract: Malignant melanoma has continually shown a pattern of increased incidence and mortality in the last 50 years. Currently, wide local excision is the mainstay of treatment of primary cutaneous melanomas. Imiquimod has been shown to clear cases of melanoma in situ, but its role in the treatment of invasive cutaneous melanomas is unknown. We present the case of a patient who achieved complete histologic clearance of invasive melanoma following treatment with topical imiquimod.
authors.affiliation: DeBusk College of Osteopathic Medicine, Lincoln Memorial University, Harrogate, Tennessee, USA.
authors.forename: Brittany E
authors.initials: BE
authors.lastname: Grady
authors.affiliation: Icahn School of Medicine at Mount Sinai, New York, New York, and private practice, St. Petersburg, Florida, USA.
authors.forename: James M
authors.initials: JM
authors.lastname: Spencer
mesh_terms: D000279:Administration, Cutaneous; D000368:Aged; D000634:Aminoquinolines / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D000077271:Imiquimod; D008297:Male; D008545:Melanoma / Q000188:drug therapy* / Q000473:pathology; D012535:Scalp; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000634:Aminoquinolines; D000970:Antineoplastic Agents; D000077271:Imiquimod