title: Validation of a protein panel for the noninvasive detection of recurrent non-muscle invasive bladder cancer.
abstract: BACKGROUND
  About 50-70% of patients with non-muscle invasive bladder cancer (NMIBC) experience relapse of disease.
  
  
  OBJECTIVE
  To establish a panel of protein biomarkers incorporated in a multiplexed microarray (BCa chip) and a classifier for diagnosing recurrent NMIBC.
  
  
  METHODS
  Urine samples from 45 patients were tested. Diagnostic performance was evaluated by receiver operating characteristic (ROC) analysis.
  
  
  RESULTS
  A multi biomarker panel (ECadh, IL8, MMP9, EN2, VEGF, past recurrences, BCG therapies and stage at diagnosis) was identified yielding an area under the curve of 0.96.
  
  
  CONCLUSIONS
  This biomarker panel represents a potential diagnostic tool for noninvasive diagnosis of recurrent NMIBC.
authors.affiliation: a Health and Environment Department, Bioresources Unit, AIT Austrian Institute of Technology GmbH , Tulln , Austria.
authors.forename: Selma
authors.initials: S
authors.lastname: Gogalic
authors.affiliation: a Health and Environment Department, Bioresources Unit, AIT Austrian Institute of Technology GmbH , Tulln , Austria.
authors.forename: Ursula
authors.initials: U
authors.lastname: Sauer
authors.affiliation: a Health and Environment Department, Bioresources Unit, AIT Austrian Institute of Technology GmbH , Tulln , Austria.
authors.forename: Sara
authors.initials: S
authors.lastname: Doppler
authors.affiliation: b Emergentec Biodevelopment GmbH , Vienna , Austria.
authors.forename: Andreas
authors.initials: A
authors.lastname: Heinzel
authors.affiliation: b Emergentec Biodevelopment GmbH , Vienna , Austria.
authors.forename: Paul
authors.initials: P
authors.lastname: Perco
authors.affiliation: b Emergentec Biodevelopment GmbH , Vienna , Austria.
authors.forename: Arno
authors.initials: A
authors.lastname: Lukas
authors.affiliation: c Department of Oncology, Faculty of Health and Medical Sciences , Leggett Building, University of Surrey , Surrey , UK.
authors.forename: Guy
authors.initials: G
authors.lastname: Simpson
authors.affiliation: c Department of Oncology, Faculty of Health and Medical Sciences , Leggett Building, University of Surrey , Surrey , UK.
authors.forename: Hardev
authors.initials: H
authors.lastname: Pandha
authors.affiliation: c Department of Oncology, Faculty of Health and Medical Sciences , Leggett Building, University of Surrey , Surrey , UK.
authors.forename: Andras
authors.initials: A
authors.lastname: Horvath
authors.affiliation: a Health and Environment Department, Bioresources Unit, AIT Austrian Institute of Technology GmbH , Tulln , Austria.
authors.forename: Claudia
authors.initials: C
authors.lastname: Preininger
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000592:standards / Q000652:urine*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis*; D012372:ROC Curve; D012008:Recurrence; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor
keywords: ECadh; EN2; IL8; MMP9; Recurrent bladder cancer; VEGF