title: Long-Term Effect of Adrenalectomy on Cardiovascular Remodeling in Patients With Pheochromocytoma.
abstract: Catecholamines may contribute to the accumulation of collagen fibers and extracellular matrix in the arterial and myocardial wall due to various mechanisms. Reversibility of this process has not been studied on both structures simultaneously.
  
  
  
  To clarify the long-term effect of excess normalization of catecholamines on carotid and myocardial wall changes in patients with pheochromocytoma or functional paraganglioma (PHEO) after tumor removal.
  
  
  
  Carotid intima-media thickness (IMT) and the left ventricular (LV) mass index were studied in 50 patients with PHEO before tumor removal and 5 years after tumor removal, and in 50 blood pressure- and age-matched essential hypertensive patients before follow-up and after 5 years of follow-up.
  
  
  
  Common carotid artery (CCA)-IMT and LV mass indexed to lean body mass (LBM).
  
  
  
  Elimination of catecholamine excess in the PHEO group resulted in a significant decrease in CCA-IMT and LV mass index from 0.86 ± 0.17 to 0.83 ± 0.18 mm (P < 0.05) and from 3.2 ± 0.9 to 2.9 ± 0.9 g/LBM (P < 0.001), respectively. In contrast, CCA-IMT and LV mass index increased significantly from 0.78 ± 0.14 to 0.81 ± 0.15 mm (P < 0.05) and from 3.1 ± 0.7 to 3.2 ± 0.6 g/LBM (P < 0.05), respectively, in patients with essential hypertension.
  
  
  
  In patients with PHEO, carotid IMT and LV mass index can significantly regress after tumor removal, in contrast to the impairment of these parameters in essential hypertensive patients during the same long-term period.
authors.affiliation: Department of Cardiology, Regional Hospital in Carlsbad and First Faculty of Medicine, Charles University, 12108 Prague, Czech Republic.
authors.forename: Bohumil
authors.initials: B
authors.lastname: Majtan
authors.affiliation: Third Medical Department.
authors.forename: Tomáš
authors.initials: T
authors.lastname: Zelinka
authors.affiliation: Third Medical Department.
authors.forename: Ján
authors.initials: J
authors.lastname: Rosa
authors.affiliation: Third Medical Department.
authors.forename: Ondrej
authors.initials: O
authors.lastname: Petrák
authors.affiliation: Third Medical Department.
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Krátká
authors.affiliation: Third Medical Department.
authors.forename: Branislav
authors.initials: B
authors.lastname: Štrauch
authors.affiliation: Third Medical Department.
authors.forename: Vladimír
authors.initials: V
authors.lastname: Tuka
authors.affiliation: Third Medical Department.
authors.forename: Alice
authors.initials: A
authors.lastname: Vránková
authors.affiliation: First Department of Surgery, and.
authors.forename: David
authors.initials: D
authors.lastname: Michalský
authors.affiliation: Department of Urology, General University Hospital and First Faculty of Medicine, Charles University, 12808 Prague, Czech Republic.
authors.forename: Kvetoslav
authors.initials: K
authors.lastname: Novák
authors.affiliation: Department of Cardiology, Institute for Clinical and Experimental Medicine, 14021 Prague, Czech Republic.
authors.forename: Dan
authors.initials: D
authors.lastname: Wichterle
authors.affiliation: Third Medical Department.
authors.forename: Jirí
authors.initials: J
authors.lastname: Widimský
authors.affiliation: Third Medical Department.
authors.forename: Robert
authors.initials: R
authors.lastname: Holaj
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000601:surgery*; D000315:Adrenalectomy; D000328:Adult; D000368:Aged; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging*; D059168:Carotid Intima-Media Thickness; D000075222:Essential Hypertension; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000150:complications*; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D010673:Pheochromocytoma / Q000601:surgery*; D020257:Ventricular Remodeling