title: Prevalence of HPV Infection in Racial-Ethnic Subgroups of Head and Neck Cancer Patients.
abstract: The landscape of HPV infection in racial/ethnic subgroups of head and neck cancer (HNC) patients has not been evaluated carefully. In this study, a meta-analysis examined the prevalence of HPV in HNC patients of African ancestry. Additionally, a pooled analysis of subject-level data was also performed to investigate HPV prevalence and patterns of p16 (CDNK2A) expression amongst different racial groups. Eighteen publications (N = 798 Black HNC patients) were examined in the meta-analysis, and the pooled analysis included 29 datasets comprised of 3,129 HNC patients of diverse racial/ethnic background. The meta-analysis revealed that the prevalence of HPV16 was higher among Blacks with oropharyngeal cancer than Blacks with non-oropharyngeal cancer. However, there was great heterogeneity observed among studies (Q test P<0.0001). In the pooled analysis, after adjusting for each study, year of diagnosis, age, gender and smoking status, the prevalence of HPV16/18 in oropharyngeal cancer patients was highest in Whites (61.1%), followed by 58.0% in Blacks and 25.2% in Asians (P<0.0001). There was no statistically significant difference in HPV16/18 prevalence in non-oropharyngeal cancer by race (P=0.682). With regard to the pattern of HPV16/18 status and p16 expression, White patients had the highest proportion of HPV16/18+/p16+ oropharyngeal cancer (52.3%), while Asians and Blacks had significantly lower proportions (23.0% and 22.6%, respectively) [P <0.0001]. Our findings suggest that the pattern of HPV16/18 status and p16 expression in oropharyngeal cancer appears to differ by race and this may contribute to survival disparities.
authors.affiliation: Cancer Prevention and Control Program, Fox Chase Cancer Center - Temple Health, Philadelphia, PA, USA Camille.ragin@fccc.edu.|Department of Epidemiology & Biostatistics, Temple University, College of Public Health, Philadelphia, PA, USA.
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authors.lastname: Ragin
authors.affiliation: Department of Otolaryngology, Temple University; and Fox Chase Cancer Center, Philadelphia, PA, USA.
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authors.lastname: Liu
authors.affiliation: Department of Epidemiology & Biostatistics, Temple University, College of Public Health, Philadelphia, PA, USA.
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authors.affiliation: Department of Pathology and Laboratory Medicine, Western Connecticut Health Network, Danbury Hospital, Danbury, CT, USA.
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authors.affiliation: Cancer Prevention and Control Program, Fox Chase Cancer Center - Temple Health, Philadelphia, PA, USA.
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authors.affiliation: Cancer Prevention and Control Program, Fox Chase Cancer Center - Temple Health, Philadelphia, PA, USA.
authors.forename: Rachel
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authors.lastname: Kennett
authors.affiliation: Department of Epidemiology & Biostatistics, Temple University, College of Public Health, Philadelphia, PA, USA.
authors.forename: Harry J M
authors.initials: HJ
authors.lastname: Groen
authors.affiliation: Cancer Prevention and Control Program, Fox Chase Cancer Center - Temple Health, Philadelphia, PA, USA.
authors.forename: Denise
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authors.lastname: Gibbs
authors.affiliation: Cancer Prevention and Control Program, Fox Chase Cancer Center - Temple Health, Philadelphia, PA, USA.|Department of Epidemiology & Biostatistics, Temple University, College of Public Health, Philadelphia, PA, USA.
authors.forename: Elizabeth
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authors.lastname: Blackman
authors.affiliation: Cancer Prevention and Control Program, Fox Chase Cancer Center - Temple Health, Philadelphia, PA, USA.
authors.forename: Michael
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authors.lastname: Esan
authors.affiliation: Department of Pathology and Anatomical Sciences, SUNY at the University at Buffalo, Buffalo, NY, USA.
authors.forename: Margaret S
authors.initials: MS
authors.lastname: Brandwein
authors.affiliation: Department of Biostatistics, Fox Chase Cancer Center - Temple Health, Philadelphia, PA, USA.
authors.forename: Karthik
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authors.affiliation: Institute of Otolaryngology, Università Cattolica del Sacro Cuore, Policlinico Agostino Gemelli, Rome, Italy.
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authors.lastname: Bussu
authors.affiliation: Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.
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authors.affiliation: Department of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
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authors.affiliation: Department of Surgery, Head and Neck Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
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authors.affiliation: Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.
authors.forename: El-Mofty
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authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
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authors.affiliation: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
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authors.affiliation: Genomic Medicine Institute, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA.
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authors.affiliation: Genomic Medicine Institute, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA.
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authors.lastname: Eng
authors.affiliation: Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA USA.
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authors.affiliation: Central Clinical School, The University of Sydney, Sydney, NSW, Australia.
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authors.affiliation: Department of Otolaryngology, Research Institute and Hospital, National Cancer Center, Gyeonggi-do, Korea.
authors.forename: Yuh-S
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authors.affiliation: Department of Oral and Maxillofacial Surgery - Plastic Surgery, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.
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authors.affiliation: Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN, 37232, USA.
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authors.affiliation: Department of Molecular Medicine, Unit of Pathology, University of Pavia, and à IRCCS Policlinico S. Matteo Foundation, Pavia, Italy.
authors.forename: Patrizia
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authors.affiliation: Department of Sciences of Public Health and Pediatrics, University of Turin, Turin, Italy.
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authors.affiliation: Department of Sciences of Public Health and Pediatrics, University of Turin, Turin, Italy.
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authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, GROW Institute, Maastricht University Medical Centre, Maastricht, The Netherlands.
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authors.affiliation: Department of Medical Microbiology, Faculty of Medicine, University of Debrecen, Hungary.
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authors.affiliation: Department of Immunology, Institute of Hematology and Blood Transfusion National Reference Laboratory for Papillomaviruses, Prague, Czech Republic.
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authors.affiliation: Department of Internal Medicine, Division of Hematology-Oncology, University of Michigan, Ann Arbor, MI, USA.
authors.forename: Francis P
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authors.affiliation: Department of Epidemiology & Biostatistics, Temple University, College of Public Health, Philadelphia, PA, USA.
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authors.affiliation: Non Communicable Diseases Research Programme, Kenya Medical Research Institute, Nairobi, Kenya.
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authors.affiliation: Departments of Population Health Science and Policy, of Thoracic Surgery, and Institute For Translational Epidemiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
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