title: Translation and validation of Hyperhidrosis Disease Severity Scale.
abstract: BACKGROUND
  The evaluation of patients with hyperhidrosis (HH) can be accomplished, among other ways, through questionnaires and scales. The Hyperhidrosis Disease Severity Scale (HDSS) has been used as a simple and quick tool to perform this evaluation. Although HDSS has been well established in several languages, it has not been translated into Portuguese, restricting its specific use for Brazilian patients. The aim of this study was to translate HDSS into Portuguese and validate it in a sample of Brazilian subjects.
  
  
  METHODS
  290 Brazilian patients (69% women, with a mean age of 28.7±9.6 years and BMI 22.4±3.9 kg/m2) diagnosed with HH were evaluated using HDSS, Quality of Life Questionnaire (QLQ) and Sweating Evolution Questionnaire (SEQ) before and after a five-week oxybutynin treatment. Regarding validation, an association between HDSS results and two other questionnaires was performed. To analyze HDSS sensitivity, evaluation of effects pre- and post-treatment with oxybutynin was conducted. Furthermore, HDSS reproducibility was analyzed in a subsample in which the scale was applied again after 7 days of the first follow-up appointment.
  
  
  RESULTS
  There was statistical correlation between HDSS and QLQ and between HDSS and SEQ before treatment and after 5 weeks. Additionally, HDSS was reproducible and sensitive to clinical changes after the treatment period.
  
  
  CONCLUSIONS
  The Portuguese version of HDSS has been validated and shown to be reproducible in a Brazilian sample. Therefore it can be used as a tool to improve medical assistance in patients with HH.
authors.affiliation: Vascular Surgery Department, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
authors.forename: Andrea Yasbek Monteiro
authors.initials: AY
authors.lastname: Varella
authors.affiliation: Vascular Surgery Department, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
authors.forename: Juliana Maria
authors.initials: JM
authors.lastname: Fukuda
authors.affiliation: Vascular Surgery Department, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
authors.forename: Marcelo Passos
authors.initials: MP
authors.lastname: Teivelis
authors.affiliation: Vascular Surgery Department, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.|Vascular Surgery Department, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.
authors.forename: José Ribas Milanez DE
authors.initials: JR
authors.lastname: Campos
authors.affiliation: Vascular Surgery Department, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.|Vascular Surgery Department, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.
authors.forename: Paulo
authors.initials: P
authors.lastname: Kauffman
authors.affiliation: Vascular Surgery Department, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
authors.forename: Gabriel Grizzo
authors.initials: GG
authors.lastname: Cucato
authors.affiliation: Vascular Surgery Department, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.
authors.forename: Pedro
authors.initials: P
authors.lastname: Puech-Leão
authors.affiliation: Vascular Surgery Department, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.|Vascular Surgery Department, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.
authors.forename: Nelson
authors.initials: N
authors.lastname: Wolosker
mesh_terms: D000293:Adolescent; D000328:Adult; D001938:Brazil; D005260:Female; D006801:Humans; D006945:Hyperhidrosis / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D008333:Mandelic Acids / Q000627:therapeutic use*; D008875:Middle Aged; D011788:Quality of Life; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D014177:Translations; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D008333:Mandelic Acids; C005419:oxybutynin