title: Using Oral and Colon Cancer Cells for Studying the Anticancer Properties of Antimicrobial Peptides.
abstract: Antimicrobial peptides (AMPs) are of importance in defense mechanism of many organisms and are potential candidate for treatment of infections in animals and humans. AMPs exhibit a wide range of immunomodulatory activities related to innate immunity, wound healing, and inflammation. AMPs also serve as drug delivery vectors, antitumor agents, and mitogenic agents. Here, we describe the investigation of anticancer and cytotoxic activities of antimicrobial peptides by colorimetric MTT assay using smooth muscle, dental pulp stem cell, human colon cancer cell line (SW620), and human oral squamous carcinoma cell line (HSC4).
authors.affiliation: Department of Medical Technology, Faculty of Allied Health Sciences, Thammasat University, 99 PaholyotinRoad, Pathumtani, 12121, Thailand. teerakul@tu.ac.th.
authors.forename: Teerakul
authors.initials: T
authors.lastname: Arpornsuwan
authors.affiliation: Department of Medical Technology, Faculty of Allied Health Sciences, Thammasat University, 99 PaholyotinRoad, Pathumtani, 12121, Thailand.
authors.forename: Wimolpak
authors.initials: W
authors.lastname: Sriwai
authors.affiliation: Department of Oral Biology, Faculty of Dentistry, Mahidol University, Bangkok, 10400, Thailand.
authors.forename: Hathaitip
authors.initials: H
authors.lastname: Sritanaudomchai
authors.affiliation: Genome Institute, National Center for Genetic Engineering and Biotechnology, Thailand Science Park, Pathumthani, 12121, Thailand.
authors.forename: Sittiruk
authors.initials: S
authors.lastname: Roytrakul
mesh_terms: D023181:Antimicrobial Cationic Peptides / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002452:Cell Count / Q000379:methods; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003110:Colonic Neoplasms; D003782:Dental Pulp / Q000166:cytology; D006801:Humans; D009062:Mouth Neoplasms; D009130:Muscle, Smooth / Q000166:cytology; D013234:Stem Cells / Q000187:drug effects / Q000378:metabolism
chemical_list: D023181:Antimicrobial Cationic Peptides; D000970:Antineoplastic Agents
keywords: Antimicrobial peptide; Dental pulp stem cell; Human colon cancer cell line (SW620); Human oral squamous carcinoma cell line (HSC4); Smooth muscle cell