title: The Relationship Between Health-Related Quality of Life and Survival in Metastatic Colorectal Cancer Patients Treated With Korean Medicine.
abstract: This study aimed to identify the relationship between health-related quality of life (HRQoL) measured by the Functional Assessment Cancer Therapy-General (FACT-G) and survival in metastatic colorectal cancer (mCRC) patients.
  
  
  
  The clinical characteristics and FACT-G scores were retrospectively reviewed in mCRC patients who visited the Cancer Center of Korean Medicine. The overall survival (OS) was calculated and compared using the Kaplan-Meier method and log-rank test. Univariate and multivariate Cox regression analyses were performed based on clinical characteristics and FACT-G scores. To identify significant differences in answer frequency, χ2tests and Fisher's exact tests were used.
  
  
  
  A total of 58 patients were reviewed. The proportion of patients who had an Eastern Cooperative Oncology Group-Performance Status ≥ 2 was 43.1%, multiple distant metastatic sites was 77.6%, liver metastases was 43.1%, been previously treated was 89.7%, and received more than the second-line chemotherapy was 75.5%. The mean total FACT-G score was 65.3 (median 65.6). The median OS was 7 months. There was no significant difference in OS between the 2 groups divided by the median values of FACT-G total and subscores. In univariate analyses, functional well-being (FWB) score had a significant impact on survival. In multivariate analyses, presence of liver metastasis, FACT-G total score, and FWB score were significant prognostic predictors of survival. No statistically different answer frequency was observed for any question regarding FWB.
  
  
  
  This study found that FACT-G total and FWB scores were potential prognostic factors for predicting OS in relapsed or refractory mCRC patients treated with Korean Medicine.
authors.affiliation: 1 Kyung Hee University, Seoul, Republic of Korea.
authors.forename: Sora
authors.initials: S
authors.lastname: Park
authors.affiliation: 1 Kyung Hee University, Seoul, Republic of Korea.
authors.forename: Wankyu
authors.initials: W
authors.lastname: Eo
authors.affiliation: 1 Kyung Hee University, Seoul, Republic of Korea.
authors.forename: Sookyung
authors.initials: S
authors.lastname: Lee
mesh_terms: D015670:Acupuncture Therapy; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use; D015179:Colorectal Neoplasms / Q000556:secondary* / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008113:Liver Neoplasms / Q000556:secondary / Q000628:therapy; D008297:Male; D055670:Medicine, Korean Traditional / Q000379:methods*; D008875:Middle Aged; D009071:Moxibustion; D008517:Phytotherapy; D011379:Prognosis; D011788:Quality of Life; D011878:Radiotherapy; D012189:Retrospective Studies; D013514:Surgical Procedures, Operative
chemical_list: D000970:Antineoplastic Agents
keywords: Korean medicine; colorectal neoplasm; neoplasm metastasis; quality of life; survival