title: Proteinuria during dengue fever in children.
abstract: OBJECTIVE
  This study aimed to investigate proteinuria occurring during dengue disease in children and assess if measurement of this parameter can help physicians in the clinical management of patients.
  
  
  METHODS
  Proteinuria was assessed by dipstick and quantified by urine protein:creatinine ratio (UPCR) in samples from patients hospitalized with a confirmed dengue infection and in healthy controls.
  
  
  RESULTS
  The dipstick tested positive in 42.9% of the patients presenting at hospital with dengue versus 20.0% in healthy controls. UPCR increased during the critical phase of the disease; peaking one week after fever onset then decreasing as the patients recovered. Patients with warnings signs or severe dengue were more likely to present with proteinuria detected by UPCR at the time of hospital admission compared to patients without warning signs. The sensitivity of this marker, however, was limited as only 16.1% of the patients with warning signs had proteinuria.
  
  
  CONCLUSIONS
  Urine dipstick and UPCR do not seem to be very valuable for the triage of the patients at the time of the initial consultation but the observation of a decrease of the UPCR during the course of the illness appears to indicate an evolution towards recovery.
authors.affiliation: Institut Pasteur in Cambodia, International Network of Pasteur Institutes, Virology Unit, Phnom Penh, Cambodia.
authors.forename: Anne-Claire
authors.initials: AC
authors.lastname: Andries
authors.affiliation: Institut Pasteur in Cambodia, International Network of Pasteur Institutes, Virology Unit, Phnom Penh, Cambodia.
authors.forename: Veasna
authors.initials: V
authors.lastname: Duong
authors.affiliation: Institut Pasteur in Cambodia, International Network of Pasteur Institutes, Epidemiology and Public Health Unit, Phnom Penh, Cambodia; Centre de coopération internationale en recherche agronomique pour le développement (CIRAD), Département ES, Unité AGIRs, Montpellier, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Cappelle
authors.affiliation: Institut Pasteur in Cambodia, International Network of Pasteur Institutes, Virology Unit, Phnom Penh, Cambodia.
authors.forename: Sivuth
authors.initials: S
authors.lastname: Ong
authors.affiliation: Institut Pasteur in Cambodia, International Network of Pasteur Institutes, Medical laboratory, Phnom Penh, Cambodia.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Kerleguer
authors.affiliation: Institut Pasteur in Cambodia, International Network of Pasteur Institutes, Epidemiology and Public Health Unit, Phnom Penh, Cambodia.
authors.forename: Sowath
authors.initials: S
authors.lastname: Ly
authors.affiliation: Institut Pasteur in Cambodia, International Network of Pasteur Institutes, Epidemiology and Public Health Unit, Phnom Penh, Cambodia.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Tarantola
authors.affiliation: Institut Pasteur in Cambodia, International Network of Pasteur Institutes, Virology Unit, Phnom Penh, Cambodia.
authors.forename: Paul F
authors.initials: PF
authors.lastname: Horwood
authors.affiliation: Institut Pasteur, Functional Genetics of Infectious Diseases Unit, Paris, France; Centre National de la Recherche Scientifique, Unité de recherche Associée 3012, Paris, France.
authors.forename: Anavaj
authors.initials: A
authors.lastname: Sakuntabhai
authors.affiliation: Institut Pasteur in Cambodia, International Network of Pasteur Institutes, Virology Unit, Phnom Penh, Cambodia.
authors.forename: Philippe
authors.initials: P
authors.lastname: Dussart
authors.affiliation: Institut Pasteur in Cambodia, International Network of Pasteur Institutes, Virology Unit, Phnom Penh, Cambodia; GlaxoSmithKline, Vaccines R&D, Scientific Affairs and Public Health, Singapore. Electronic address: philippe.x.buchy@gsk.com.
authors.forename: Philippe
authors.initials: P
authors.lastname: Buchy
mesh_terms: D019540:Area Under Curve; D015415:Biomarkers / Q000652:urine; D002160:Cambodia; D002648:Child; D003404:Creatinine / Q000652:urine; D003715:Dengue / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D011446:Prospective Studies; D011507:Proteinuria / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism
chemical_list: D015415:Biomarkers; D003404:Creatinine
keywords: Dengue; UPCR; dipstick; proteinuria; urine; urine electrophoresis