title: The additional effects of a probiotic mix on abdominal adiposity and antioxidant Status: A double-blind, randomized trial.
abstract: To investigate whether a probiotic mix has additional effects when compared with an isolated dietary intervention on the body composition, lipid profile, endotoxemia, inflammation, and antioxidant profile.
  
  
  
  Women who had excess weight or obesity were recruited to a randomized, double-blind trial and received a probiotic mix (Lactobacillus acidophilus and casei; Lactococcus lactis; Bifidobacterium bifidum and lactis; 2 × 1010colony-forming units/day) (n = 21) or placebo (n = 22) for 8 weeks. Both groups received a dietary prescription. Body composition was assessed by anthropometry and dual-energy X-ray absorptiometry. The lipid profile, lipid accumulation product, plasma fatty acids, lipopolysaccharide, interleukin-6, interleukin-10, tumor necrosis factor-α, adiponectin, and the antioxidant enzymes activities were analyzed.
  
  
  
  In comparison with the dietary intervention group, the dietary intervention + probiotic mix group showed a greater reduction in the waist circumference (-3.40% vs. -5.48%, P = 0.03), waist-height ratio (-3.27% vs. -5.00%, P = 0.02), conicity index (-2.43% vs. -4.09% P = 0.03), and plasma polyunsaturated fatty acids (5.65% vs. -18.63%, P = 0.04) and an increase in the activity of glutathione peroxidase (-16.67% vs. 15.62%, P < 0.01).
  
  
  
  Supplementation of a probiotic mix reduced abdominal adiposity and increased antioxidant enzyme activity in a more effective way than an isolated dietary intervention.
authors.affiliation: Clinical and Sports Nutrition Research Laboratory (Labince), Faculty of Nutrition, Federal University of Goiás, Goiânia, Goiás, Brazil.
authors.forename: Aline Corado
authors.initials: AC
authors.lastname: Gomes
authors.affiliation: Clinical and Sports Nutrition Research Laboratory (Labince), Faculty of Nutrition, Federal University of Goiás, Goiânia, Goiás, Brazil.
authors.forename: Rávila Graziany Machado
authors.initials: RG
authors.lastname: de Sousa
authors.affiliation: Clinical and Sports Nutrition Research Laboratory (Labince), Faculty of Nutrition, Federal University of Goiás, Goiânia, Goiás, Brazil.
authors.forename: Patrícia Borges
authors.initials: PB
authors.lastname: Botelho
authors.affiliation: Clinical and Sports Nutrition Research Laboratory (Labince), Faculty of Nutrition, Federal University of Goiás, Goiânia, Goiás, Brazil.
authors.forename: Tatyanne Letícia Nogueira
authors.initials: TL
authors.lastname: Gomes
authors.affiliation: School of Applied Sciences, State University of Campinas, Campinas, São Paulo, Brazil.
authors.forename: Patrícia Oliveira
authors.initials: PO
authors.lastname: Prada
authors.affiliation: Clinical and Sports Nutrition Research Laboratory (Labince), Faculty of Nutrition, Federal University of Goiás, Goiânia, Goiás, Brazil.
authors.forename: João Felipe
authors.initials: JF
authors.lastname: Mota
mesh_terms: D050154:Adiposity / Q000187:drug effects*; D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage*; D015992:Body Mass Index; D004038:Diet, Reducing / Q000379:methods; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D056128:Obesity, Abdominal / Q000188:drug therapy* / Q000517:prevention & control; D019936:Probiotics / Q000008:administration & dosage*
chemical_list: D000975:Antioxidants