title: Stimuli-Responsive Self-Assembled DNA Nanomaterials for Biomedical Applications.
abstract: Stimuli-responsive DNA-based materials represent a major class of remarkable functional nanomaterials for nano-biotechnological applications. In this review, recent progress in the development of stimuli-responsive systems based on self-assembled DNA nanostructures is introduced and classified. Representative examples are presented in terms of their design, working principles and mechanisms to trigger the response of the stimuli-responsive DNA system upon expose to a large variety of stimuli including pH, metal ions, oligonucleotides, small molecules, enzymes, heat, and light. Substantial in vitro studies have clearly revealed the advantages of the use of stimuli-responsive DNA nanomaterials in different biomedical applications, particularly for biosensing, drug delivery, therapy and diagnostic purposes in addition to bio-computing. Some of the challenges faced and suggestions for further development are also highlighted.
authors.affiliation: Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR, China.|Key Laboratory of Biochip Technology, Biotech and Health Centre, Shenzhen Research Institute of City University of Hong Kong, Shenzhen, 518057, China.
authors.forename: Ziwen
authors.initials: Z
authors.lastname: Dai
authors.affiliation: Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR, China.
authors.forename: Hoi Man
authors.initials: HM
authors.lastname: Leung
authors.affiliation: Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR, China.|Key Laboratory of Biochip Technology, Biotech and Health Centre, Shenzhen Research Institute of City University of Hong Kong, Shenzhen, 518057, China.
authors.forename: Pik Kwan
authors.initials: PK
authors.lastname: Lo
mesh_terms: D020811:Biomedical Technology / Q000379:methods*; D015374:Biosensing Techniques; D004247:DNA / Q000737:chemistry*; D016503:Drug Delivery Systems; D006801:Humans; D049329:Nanostructures / Q000737:chemistry*
chemical_list: D004247:DNA
keywords: DNA nanostructures; biomedical; responsive; stimuli; triggers