title: Radical Desulfur-Fragmentation and Reconstruction of Enol Triflates: Facile Access to α-Trifluoromethyl Ketones.
abstract: We report an efficient oxidative radical desulfur-fragmentation and reconstruction of enol triflates for the synthesis of α-CF3ketones. Preliminary mechanistic studies disclosed that oxidative fragmentation to release a CF3radical from the triflyl group of enol triflate and subsequent addition of the CF3radical to another enol triflate form the desired α-CF3ketones. This method provides a new approach to α-CF3ketones, featuring the utilization of catalytic amount of oxidants, broad substrate scope, and potential to control the regioselectivity.
authors.affiliation: Department of Chemistry, Fuzhou University, Fuzhou, 350116, China.
authors.forename: Xiaolong
authors.initials: X
authors.lastname: Su
authors.affiliation: Department of Chemistry, Fuzhou University, Fuzhou, 350116, China.
authors.forename: Honggui
authors.initials: H
authors.lastname: Huang
authors.affiliation: Department of Chemistry, Fuzhou University, Fuzhou, 350116, China.
authors.forename: Yaofeng
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: Department of Chemistry, Fuzhou University, Fuzhou, 350116, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Li
keywords: enol triflates; ketones; radical fragmentation; synthetic methods; trifluoromethylation