title: Both immune hormone IL-10 and parathormone tend to increase in serum of old osteoporotic people independently of 1, 25 dihydroxy vitamin D3.
abstract: BACKGROUND
  In this study, we determined the serum levels of IL-17A and IL-10 in context with 1, 2 dihydroxy vitamin D3, parathormone and Ca2+/Pi ions to investigate their pathological or protective roles respectively in bone metabolism.
  
  
  METHODS
  The bone mineral density (BMD) was determined for 1203 participants using energy X-ray absorptiometry. Subjects with a history of diseases and using bone metabolism medications were excluded and finally serum IL-10 was measured in 82 osteoporotic and 74 healthy individuals (mean age ±SD of 71.04±6.9 and 68.58±6.9 respectively). Also, the serum level of IL-17A was assessed in 42 osteoporotic and 39 non-osteoporotic subjects (mean age±SD of 69.40±6.7 and 70.77±7.1, respectively). Serum levels of 1, 25-dihydroxyvitamin D3, Ca2+/Pi ions and parathormone were extracted from AHAP cohort data bank.
  
  
  RESULTS
  IL-17A was detectable in 7.42(16.67%) osteoporotic subjects and 3.39(7.69%) normal subjects. Surprisingly, patient subjects exhibited a higher level of serum IL-10 than normal subjects (P=0.023). We found that the serum parathormone levels tend to increase in patient group (P=0.003) in comparison to normal control with no correlation with Il-10 levels. There was no significant difference between the two groups in the serum levels of 1, 25-dihydroxyvitamin D3, Ca2+and Piions.
  
  
  CONCLUSIONS
  In reaction to chronic inflammation old osteoporotic patients independent of 1, 25 dihydroxy vitamin D3 may produce a higher level of IL-10 to dampen production of inflammatory cytokines including IL-17A which in turn leads to speeding up parathormone production ultimately reaching a new homeostasis status in bone metabolism with normal serum Ca2+/Pi ions.
authors.affiliation: Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Mohamad
authors.initials: M
authors.lastname: Teimourian
authors.affiliation: Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Zeinab
authors.initials: Z
authors.lastname: Jafaraian
authors.affiliation: Immunology Department, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Seyed-Reza
authors.initials: SR
authors.lastname: Hosseini
authors.affiliation: Immunology Department, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Mahsa
authors.initials: M
authors.lastname: Rahmani
authors.affiliation: Immunology Department, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Mogjan
authors.initials: M
authors.lastname: Bagherzadeh
authors.affiliation: Immunology Department, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Azin
authors.initials: A
authors.lastname: Aghamajidi
authors.affiliation: Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Bijani
authors.affiliation: Department of Radiology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Hajighorban
authors.initials: H
authors.lastname: Nooreddini
authors.affiliation: Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Amrollah
authors.initials: A
authors.lastname: Mostafazadeh
keywords: 1; 25dihydroxy vitamin D3; Elderly; IL-10; IL-17A; Osteoporosis; Parathormone