title: Skeletal Scintigraphy in Radiation-Induced Fibrosis With Lymphedema.
abstract: Despite increasing reliance on CT, MRI, and FDG PET/CT for oncological imaging, whole-body skeletal scintigraphy remains a frontline modality for staging and surveillance of osseous metastatic disease. We present a 54-year-old woman with metastatic breast cancer who received palliative external-beam radiation to the left ilium. Serial follow-up Tc-MDP bone scans demonstrated progressive soft-tissue uptake in her left lower extremity, extending from thigh to leg, with associated enlargement and skin thickening, consistent with lymphedema related to radiation-induced fibrosis. Correlative abdominopelvic CT scans confirmed fibrotic changes in the left thigh.
authors.affiliation: From the *University of Kentucky College of Medicine; †Department of Radiology, University of Kentucky College of Medicine; and ‡Division of Nuclear Medicine & Molecular Imaging, Department of Radiology, University of Kentucky College of Medicine, Lexington, KY.
authors.forename: Jieqi
authors.initials: J
authors.lastname: Wang
authors.forename: Arya M
authors.initials: AM
authors.lastname: Iranmanesh
authors.forename: M Elizabeth
authors.initials: ME
authors.lastname: Oates
mesh_terms: D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary; D001943:Breast Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D005260:Female; D005355:Fibrosis / Q000000981:diagnostic imaging / Q000209:etiology; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008209:Lymphedema / Q000000981:diagnostic imaging* / Q000209:etiology; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D000072078:Positron Emission Tomography Computed Tomography; D019275:Radiopharmaceuticals; D011878:Radiotherapy / Q000009:adverse effects; D013669:Technetium Tc 99m Medronate
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D013669:Technetium Tc 99m Medronate