title: Effect of grape juice consumption on antioxidant activity and interleukin-6 concentration in lactating rats.
abstract: OBJECTIVE
  This study evaluated the effect of grape juice consumption on the antioxidant capacity and the interleukin-6 blood level of lactating rats.
  
  
  METHODS
  Eighteen Wistar rats, lactating females adult, were divided into two groups: control group (CG) and grape juice group (GJG). The antioxidant activity was determined by the method of 2,2-diphenyl-1-picrylhydrazyl (DPPH)-kidnapping of free radicals (DPPH) and oxygen radical absorbance capacity (ORAC), and the interleukin-6 was determined by Enzyme-Linked Immunosorbent Assay (ELISA) method. The data were presented as mean and standard deviation.
  
  
  RESULTS
  The antioxidant capacity was higher (p < 0.05) in the GJG (25.00 ± 3.08 µmol eq. Trolox/g) than in the CG (10.00 ± 3.11 µmol eq. Trolox/g), by the ORAC method. The interleukin-6 (pg/ml) level was lower in the grape juice group than in CG.
  
  
  CONCLUSIONS
  The consumption of grape juice during lactation improves the antioxidant capacity in lactating rats and seems capable to decrease the inflammatory activity.
authors.affiliation: Federal Fluminense University. Rio de Janeiro, Brazil. vilma.blondet@gmail.com.
authors.forename: Sabrina Baptista Alves
authors.initials: SB
authors.lastname: Faria
authors.forename: Vanessa
authors.initials: V
authors.lastname: Rosse
authors.forename: Juliana Furtado
authors.initials: JF
authors.lastname: Dias
authors.forename: Nara
authors.initials: N
authors.lastname: Moreira Xavier
authors.forename: Vilma Blondet
authors.initials: VB
authors.lastname: Azeredo
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001628:Beverages; D015415:Biomarkers / Q000097:blood; D005260:Female; D015850:Interleukin-6 / Q000097:blood*; D007774:Lactation / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D027843:Vitis
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D015850:Interleukin-6; C577686:interleukin-6, mouse
keywords: Lactation. Grape  juice. Antioxidant  activity. Interleukin-6.  Wistar rats.