title: Does Postoperative Erythropoietin Reduce Transfusions and Hemodynamic Instability Following Liposuction, Either Alone or Associated with Abdominoplasty or Mammaplasty? A Comparative, Prospective Study of 50 Consecutive Patients.
abstract: BACKGROUND
  Erythropoietin (EPO) is a hematopoietic growth factor and an alternative to avoid blood transfusion in high-blood-loss surgeries. We evaluate EPO efficacy to reduce clinically relevant anemia and dehydration in patients undergoing liposuction.
  
  
  METHODS
  We prospectively evaluated 50 consecutive patients subjected to liposuction greater than 2.5 L and alternately assigned into two comparable groups (25 patients each), except for the postoperative administration of erythropoietin (4000 UI per day subcutaneously) during five consecutive days. Incidence data for blood transfusion or parenteral hydration were collected. Statistical analyses were performed with significance at p value <5%.
  
  
  RESULTS
  There was no significant difference between groups related to any preoperative feature or the incidence of dehydration (p = 0.1099) or transfusion (p = 1.0).
  
  
  CONCLUSIONS
  Postoperative erythropoietin administration was not effective in preventing blood transfusion for anemia or parenteral hydration for hemodynamic instability in patients undergoing major liposuction.
  
  
  METHODS
  This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors http://www.springer.com/00266.
authors.affiliation: Rosique Plastic Surgery, Antonio Diederichsen Street, 400, Suite 1204, Ribeirão Preto, São Paulo, 14020-250, Brazil. Rodrigo@rosique.com.br.
authors.forename: Rodrigo G
authors.initials: RG
authors.lastname: Rosique
authors.affiliation: Rosique Plastic Surgery, Antonio Diederichsen Street, 400, Suite 1204, Ribeirão Preto, São Paulo, 14020-250, Brazil.
authors.forename: Marina J F
authors.initials: MJ
authors.lastname: Rosique
authors.affiliation: Rosique Plastic Surgery, Antonio Diederichsen Street, 400, Suite 1204, Ribeirão Preto, São Paulo, 14020-250, Brazil.
authors.forename: Mariana Quintino
authors.initials: MQ
authors.lastname: Rabelo
mesh_terms: D061645:Abdominoplasty / Q000009:adverse effects* / Q000379:methods; D000328:Adult; D000368:Aged; D000740:Anemia / Q000188:drug therapy* / Q000209:etiology; D001803:Blood Transfusion / Q000706:statistics & numerical data*; D015992:Body Mass Index; D016022:Case-Control Studies; D003131:Combined Modality Therapy; D003681:Dehydration / Q000188:drug therapy* / Q000209:etiology; D004921:Erythropoietin / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007279:Injections, Subcutaneous; D015187:Lipectomy / Q000009:adverse effects* / Q000379:methods; D008875:Middle Aged; D011182:Postoperative Care / Q000379:methods; D011446:Prospective Studies; D012016:Reference Values; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D004921:Erythropoietin
keywords: Erythropoietin; Hemodynamic instability; Liposuction; Transfusion