title: Prostate cancer diagnosis: Efficacy of a simple electromagnetic MRI-TRUS fusion method to target biopsies.
abstract: OBJECTIVE
  To assess that transrectal ultrasound guidance (TRUS) targeted biopsies (TB) aimed with an easy to use electronic real-time fusion registration device have a higher rate of prostate cancer (PC) detection than standard biopsies (SB).
  
  
  METHODS
  This prospective study included 130 patients referred for TRUS biopsies after suspicious MRI. They underwent 16-core SB and 2 to 3 cores in each MRI suspicious area, using a fusion software. We noted SB and TB positivity for PC and Gleason score (GS). We used the McNemar test to compare SB and TB, with a statistical significance p<0.05.
  
  
  RESULTS
  Among 130 patients, 68.5% had PC. Additional time due to the fusion registration was 3.3 min. One hundred fifteen patients (88.4%) had pathological findings on the histological analysis (prostate cancer n=89, others n=26). TB diagnosed PC in 75 patients with negative SB. Positivity rate for PC was significantly higher for TB than SB (p=0.03). Among highly suspicious MRI lesions, detection rate of histological abnormalities using SB and TB was 96% with 79.7% of PC. Most PC that TB diagnosed alone were clinically significant (86.3%).
  
  
  CONCLUSIONS
  TRUS biopsies performed with a simple MRI and US electronic fusion is an unrestrainedly method to increase PC diagnosis.
authors.affiliation: Department of Radiology B, University Hospital of Strasbourg, New Civil Hospital, 1, place de l' hôpital BP 426, 67091, Strasbourg Cedex, France.
authors.forename: Amina
authors.initials: A
authors.lastname: Jelidi
authors.affiliation: Department of Radiology B, University Hospital of Strasbourg, New Civil Hospital, 1, place de l' hôpital BP 426, 67091, Strasbourg Cedex, France.
authors.forename: Mickael
authors.initials: M
authors.lastname: Ohana
authors.affiliation: Department of Radiology B, University Hospital of Strasbourg, New Civil Hospital, 1, place de l' hôpital BP 426, 67091, Strasbourg Cedex, France.
authors.forename: Aïssam
authors.initials: A
authors.lastname: Labani
authors.affiliation: Department of Radiology B, University Hospital of Strasbourg, New Civil Hospital, 1, place de l' hôpital BP 426, 67091, Strasbourg Cedex, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Alemann
authors.affiliation: Department of Urology, University Hospital of Strasbourg, New Civil Hospital, 1, place de l'hôpital BP 426, 67091, Strasbourg Cedex, France.
authors.forename: Herve
authors.initials: H
authors.lastname: Lang
authors.affiliation: Department of Radiology B, University Hospital of Strasbourg, New Civil Hospital, 1, place de l' hôpital BP 426, 67091, Strasbourg Cedex, France. Electronic address: catherine.roy@chru-strasbourg.fr.
authors.forename: Catherine
authors.initials: C
authors.lastname: Roy
mesh_terms: D000368:Aged; D062005:Biopsy, Large-Core Needle / Q000379:methods; D055590:Electromagnetic Phenomena; D006801:Humans; D061705:Image-Guided Biopsy / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D053783:Magnetic Resonance Imaging, Interventional / Q000379:methods; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D011446:Prospective Studies; D011467:Prostate / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000473:pathology*; D012984:Software
keywords: Biopsy; Diagnosis; Interventional; Magnetic resonance imaging; Neoplasms; Prostate; Ultrasonography