title: Iodocyclization of N-Arylpropynamides Mediated by Hypervalent Iodine Reagent: Divergent Synthesis of Iodinated Quinolin-2-ones and Spiro[4,5]trienones.
abstract: PhI(OCOCF3)2acts as both a nonmetal oxidant and an iodination reagent to trigger iodocyclization of N-arylpropynamides while selectively affording iodinated quinolin-2-ones or the spiro[4,5]trienone skeleton, depending on the substituent pattern. In cases where the N-arylpropynamide bears a para-fluorine on the aniline ring, the spiro compound is formed via an exclusive defluorination process; otherwise, the product was quinolin-2-one.
authors.affiliation: School of Pharmaceutical Science and Technology, Tianjin University , Tianjin 300072, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: School of Pharmaceutical Science and Technology, Tianjin University , Tianjin 300072, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhang
authors.affiliation: School of Pharmaceutical Science and Technology, Tianjin University , Tianjin 300072, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: School of Pharmaceutical Science and Technology, Tianjin University , Tianjin 300072, China.
authors.forename: Linxin
authors.initials: L
authors.lastname: Ruan
authors.affiliation: School of Pharmacy, Tianjin Medical University , Tianjin 300070, China.
authors.forename: Jiacheng
authors.initials: J
authors.lastname: Zhang
authors.affiliation: School of Pharmaceutical Science and Technology, Tianjin University , Tianjin 300072, China.
authors.forename: Daisy
authors.initials: D
authors.lastname: Zhang-Negrerie
authors.affiliation: School of Pharmaceutical Science and Technology, Tianjin University , Tianjin 300072, China.
authors.forename: Yunfei
authors.identifier: 0000-0002-0213-2854
authors.initials: Y
authors.lastname: Du