title: Biocompatible electrospinning chitosan nanofibers: A novel delivery system with superior local cancer therapy.
abstract: In this study, an electrospinning technique was used for the fabrication of novel biomedicated nanofibers which are applied for preventing wound infections and local chemotherapy. CURs containing nanofibers with a crosslinking agent (Si-O-Si network) have been produced through functionalization of graphene oxide with APTES. In vitro drug release profile results showed the novel nanofibers could limit the drug's initial burst release and provide better sustainability in comparison with the blend nanofibers without modified GO. The novel delivery vehicle can inhibit the growth of MRSA and S. epidermidis up to 94% and 88%. Also in vitro cell toxicity experiments which were performed by XTT method on MCF-7, HEP G2 and L929 cell lines showed that anticancer activity of CUR remained intact even after loading into nanofibers. This result suggested that the fGO-Si-CUR including nanofibers were a promising candidate for postoperative chemotherapy.
authors.affiliation: Department of Polymer & Materials Chemistry, Faculty of Chemistry and Petroleum Sciences, Shahid Beheshti University, G.C, 1983969411, Tehran, Iran. Electronic address: r_sedghi@sbu.ac.ir.
authors.forename: Roya
authors.initials: R
authors.lastname: Sedghi
authors.affiliation: Department of Polymer & Materials Chemistry, Faculty of Chemistry and Petroleum Sciences, Shahid Beheshti University, G.C, 1983969411, Tehran, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Shaabani
authors.affiliation: Nanobiotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
authors.forename: Zohreh
authors.initials: Z
authors.lastname: Mohammadi
authors.affiliation: Nanobiotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
authors.forename: Fatemeh Yazdi
authors.initials: FY
authors.lastname: Samadi
authors.affiliation: Department of Microbiology, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: Elham
authors.initials: E
authors.lastname: Isaei
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000494:pharmacology / Q000592:standards; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D048271:Chitosan / Q000737:chemistry* / Q000494:pharmacology; D016503:Drug Delivery Systems / Q000592:standards*; D065546:Drug Liberation; D006801:Humans; D057139:Nanofibers / Q000737:chemistry*; D009369:Neoplasms / Q000628:therapy*
chemical_list: D000970:Antineoplastic Agents; D001672:Biocompatible Materials; D048271:Chitosan
keywords: Antibacterial activity; Anticancer activity; Curcumin; fGO-Si-CUR containing nanofibers