title: Beyond proneural: emerging functions and regulations of proneural proteins.
abstract: Proneural proteins, which include Ascl1, Atoh1 and Neurogenins épinière in vertebrates and Achaete-Scute proteins and Atonal in Drosophila, are expressed in the developing nervous system throughout the animal kingdom and have an essential and well-characterised role in specifying the neural identity of progenitors. New properties and additional roles of these factors have emerged in recent years, including the regulation of stem cell proliferation and the capacity to reprogram many types of cells into neurons. This review will focus on these recent findings. The review will also discuss the mechanisms that allow proneural proteins to induce the transcription of their target genes in different chromatin contexts and the phosphorylation events and other post-transcriptional mechanisms that regulate the proneural proteins themselves.
authors.affiliation: The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. Electronic address: francois.guillemot@crick.ac.uk.
authors.forename: François
authors.initials: F
authors.lastname: Guillemot
authors.affiliation: Sorbonne Universités, UPMC Univ Paris 06, Inserm, CNRS, Institut du Cerveau et la Moëlle Epinière (ICM) - Hôpital Pitié-Salpêtrière, Boulevard de l'hôpital, F-75013 Paris, France. Electronic address: bassem.hassan@icm-institute.org.
authors.forename: Bassem A
authors.initials: BA
authors.lastname: Hassan
mesh_terms: D000818:Animals; D018507:Gene Expression Regulation, Developmental; D009420:Nervous System / Q000196:embryology*; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D011498:Protein Precursors / Q000235:genetics* / Q000378:metabolism
chemical_list: D011498:Protein Precursors