title: Toward Production of Pure13C Hyperpolarized Metabolites Using Heterogeneous Parahydrogen-Induced Polarization of Ethyl[1-13C]acetate.
abstract: Here, we report the production of13C-hyperpolarized ethyl acetate via heterogeneously catalyzed pairwise addition of parahydrogen to vinyl acetate over TiO2-supported rhodium nanoparticles, followed by magnetic field cycling. Importantly, the hyperpolarization is demonstrated even at the natural abundance of13C isotope (ca. 1.1%) along with the easiest separation of the catalyst from the hyperpolarized liquid.
authors.affiliation: Laboratory of Magnetic Resonance Microimaging, International Tomography Center SB RAS, Institutskaya St. 3A, 630090 Novosibirsk, Russia; Novosibirsk State University, Pirogova St. 2, 630090 Novosibirsk, Russia.
authors.forename: K V
authors.initials: KV
authors.lastname: Kovtunov
authors.affiliation: Vanderbilt University, Institute of Imaging Science (VUIIS), Department of Radiology, Department of Biomedical Engineering, Vanderbilt-Ingram Cancer Center (VICC), Nashville, Tennessee, 37232-2310, USA.
authors.forename: D A
authors.initials: DA
authors.lastname: Barskiy
authors.affiliation: Laboratory of Magnetic Resonance Microimaging, International Tomography Center SB RAS, Institutskaya St. 3A, 630090 Novosibirsk, Russia; Novosibirsk State University, Pirogova St. 2, 630090 Novosibirsk, Russia.
authors.forename: O G
authors.initials: OG
authors.lastname: Salnikov
authors.affiliation: Vanderbilt University, Institute of Imaging Science (VUIIS), Department of Radiology, Department of Biomedical Engineering, Vanderbilt-Ingram Cancer Center (VICC), Nashville, Tennessee, 37232-2310, USA.
authors.forename: R V
authors.initials: RV
authors.lastname: Shchepin
authors.affiliation: Vanderbilt University, Institute of Imaging Science (VUIIS), Department of Radiology, Department of Biomedical Engineering, Vanderbilt-Ingram Cancer Center (VICC), Nashville, Tennessee, 37232-2310, USA.
authors.forename: A M
authors.initials: AM
authors.lastname: Coffey
authors.affiliation: Novosibirsk State University, Pirogova St. 2, 630090 Novosibirsk, Russia; Boreskov Institute of Catalysis SB RAS 5 Acad. Lavrentiev Pr., Novosibirsk, 630090 Russia.
authors.forename: L M
authors.initials: LM
authors.lastname: Kovtunova
authors.affiliation: Novosibirsk State University, Pirogova St. 2, 630090 Novosibirsk, Russia; Boreskov Institute of Catalysis SB RAS 5 Acad. Lavrentiev Pr., Novosibirsk, 630090 Russia.
authors.forename: V I
authors.initials: VI
authors.lastname: Bukhtiyarov
authors.affiliation: Laboratory of Magnetic Resonance Microimaging, International Tomography Center SB RAS, Institutskaya St. 3A, 630090 Novosibirsk, Russia; Novosibirsk State University, Pirogova St. 2, 630090 Novosibirsk, Russia.
authors.forename: I V
authors.initials: IV
authors.lastname: Koptyug
authors.affiliation: Vanderbilt University, Institute of Imaging Science (VUIIS), Department of Radiology, Department of Biomedical Engineering, Vanderbilt-Ingram Cancer Center (VICC), Nashville, Tennessee, 37232-2310, USA; Russian Academy of Sciences, Leninskiy Prospect 14, 119991 Moscow, Russia.
authors.forename: E Y
authors.initials: EY
authors.lastname: Chekmenev