title: Cutaneous Exophiala oligosperma Infection in a Patient with Bullous Pemphigoid with a Review of the Literature.
abstract: Phaeohyphomycosis is an infection caused by a heterogeneous group of melanized fungi. Human infections due to members of genus Exophiala are rare but may occur at any part of the body. We herein report a case of an 85-year-old male with a history of bullous pemphigoid who presented with a chronic, non-healing wound on his right dorsal hand for a month. Direct microscopy of a pus sample from the base of the ulcer revealed strands of pigmented, moniliform hyphae. The isolate was identified as E. oligosperma based on morphological characters and sequencing of the rDNA internal transcribed spacers (ITS) and partial beta-tubulin gene. The patient received a three-month course of oral itraconazole with no recurrence.
authors.affiliation: Department of Dermatology, Chang Gung Memorial Hospital, Linko, Taipei, Keelung, Taiwan.|College of Medicine, Chang Gung University, Taoyuan, Taiwan.|Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan.
authors.forename: Chau Yee
authors.initials: CY
authors.lastname: Ng
authors.affiliation: CBS-KNAW Fungal Biodiversity Centre, Utrecht, The Netherlands.
authors.forename: Sybren
authors.initials: S
authors.lastname: de Hoog
authors.affiliation: Department of Dermatology, Chang Gung Memorial Hospital, Linko, Taipei, Keelung, Taiwan.|College of Medicine, Chang Gung University, Taoyuan, Taiwan.
authors.forename: Hua-En
authors.initials: HE
authors.lastname: Li
authors.affiliation: Department of Dermatology, Chang Gung Memorial Hospital, Linko, Taipei, Keelung, Taiwan.|College of Medicine, Chang Gung University, Taoyuan, Taiwan.
authors.forename: Yung-Yi
authors.initials: YY
authors.lastname: Lee
authors.affiliation: Department of Dermatology, Chang Gung Memorial Hospital, Linko, Taipei, Keelung, Taiwan.|College of Medicine, Chang Gung University, Taoyuan, Taiwan.
authors.forename: Chun-Bing
authors.initials: CB
authors.lastname: Chen
authors.affiliation: Department of Dermatology, Chang Gung Memorial Hospital, Linko, Taipei, Keelung, Taiwan. sunfungus@gmail.com.|College of Medicine, Chang Gung University, Taoyuan, Taiwan. sunfungus@gmail.com.|Department of Dermatology, Chang Gung Memorial Hospital, Linkou Branch, No. 5, Fushin Street, Taoyuan, Taiwan. sunfungus@gmail.com.
authors.forename: Pei-Lun
authors.initials: PL
authors.lastname: Sun
mesh_terms: D000369:Aged, 80 and over; D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D021903:DNA, Ribosomal Spacer / Q000737:chemistry / Q000235:genetics; D005093:Exophiala / Q000302:isolation & purification*; D006225:Hand / Q000473:pathology; D006801:Humans; D008297:Male; D008828:Microbiological Techniques; D008853:Microscopy; D010391:Pemphigoid, Bullous / Q000209:etiology* / Q000473:pathology*; D060446:Phaeohyphomycosis / Q000175:diagnosis* / Q000473:pathology*; D010802:Phylogeny; D017422:Sequence Analysis, DNA; D014404:Tubulin / Q000235:genetics
chemical_list: D004271:DNA, Fungal; D021903:DNA, Ribosomal Spacer; D014404:Tubulin
keywords: Bullous pemphigoid; Exophiala oligosperma; Fungal infection; Phaeohyphomycosis; Skin