title: Probiotic: effectiveness nutrition in cancer treatment and prevention.
abstract: Among the neoplasias, colorectal cancer is one of the leading causes of cancer death in men and women. The increasing incidence of this type of cancer is due to the increase in the population's life expectancy, by the increase in chronic inflammatory bowel diseases, primarily ulcerative colitis and Crohn's disease, and the change in eating habits. The American Cancer Society (2011) shows that diet might be responsible for approximately 30% of cancer cases in developed countries, moreover when considering only colorectal cancer, the number can reach 30% to 50%. Probiotics are effective in the prevention and treatment of many bowel diseases as inflammatory bowel disease (IBD), diarrhea, irritable bowel syndrome, gluten intolerance, gastroenteritis, Helicobacter pyloriinfection, and colon cancer. Classical examples are strains from the Lactobacillus, and Bifidobacteriumgenus that have probiotic proprieties with a potential use in the prophylaxis, as well as in the treatment of a variety of gastrointestinal tract disorders. Researchers are focusing on extremely important studies regarding the possibility of using probiotics to promote a balanced microbiota composition, and a sufficient immunological surveillance system as a way to prevent cancer. Considering the fact that the human intestines host 100 trillion bacteria, including more than 1,000 species, there is still need to perform more in depth investigations in order to find probiotics with potential to prevent, and treat cancerous diseases, adding a very promising effect to this already successful panorama. This revision aims to conduct a review of the most recent studies correlating probiotics and its cancer preventing and treatment potential.
authors.affiliation: Laboratório de Cultura de Células. Programa de Pós-Graduação em Biotecnologia. Centro Universitário UNIVATES (UNIVATES). Lajeado, Rio Grande do Sul. Brasil. marcia.goettert@univates.br.
authors.forename: Débora Mara
authors.initials: DM
authors.lastname: Kich
authors.forename: Angélica
authors.initials: A
authors.lastname: Vincenzi
authors.forename: Fernanda
authors.initials: F
authors.lastname: Majolo
authors.forename: Claucia Fernanda
authors.initials: CF
authors.lastname: Volken de Souza
authors.forename: Márcia Inês
authors.initials: MI
authors.lastname: Goettert
mesh_terms: D000818:Animals; D006801:Humans; D009369:Neoplasms / Q000517:prevention & control* / Q000628:therapy*; D019936:Probiotics / Q000627:therapeutic use*
keywords: Colorectal cancer.  Inflammatory bowel  disease. Probiotics.  Intestinal microbiota.  Immune system.