title: One Niche to Rule Both Maintenance and Loss of Stemness in HSCs.
abstract: Hemato-lymphopoiesis initiated by hematopoietic stem cells (HSCs) is tightly regulated by factors present in the bone marrow (BM) niche. Using genetically modified mice, Gomes et al. (2016) show that IL-7 is produced by HSC niche-forming cells and find that the same niche that controls HSC self-renewal can also support differentiation.
authors.affiliation: Department of Molecular Immunology, Toho University School of Medicine, Tokyo 143-8540, Japan. Electronic address: motonari.kondo@med.toho-u.ac.jp.
authors.forename: Motonari
authors.initials: M
authors.lastname: Kondo
mesh_terms: D000818:Animals; D001853:Bone Marrow; D001854:Bone Marrow Cells / Q000166:cytology*; D002454:Cell Differentiation; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D038041:Lymphopoiesis; D051379:Mice