title: [Regulation of hypnosis in Propofol anesthesia administration based on non-linear control strategy].
abstract: Continuous adjustment of Propofol in manual delivery of anesthesia for conducting a surgical procedure overburdens the workload of an anesthetist who is working in a multi-tasking scenario. Going beyond manual administration and Target Controlled Infusion, closed-loop control of Propofol infusion has the potential to offer several benefits in terms of handling perturbations and reducing the effect of inter-patient variability. This paper proposes a closed-loop automated drug administration approach to control Depth Of Hypnosis in anesthesia. In contrast with most of the existing research on anesthesia control which makes use of linear control strategies or their improved variants, the novelty of the present research lies in applying robust control strategy i.e. Sliding Mode Control to accurately control drug infusion. Based on the derived patient's model, the designed controller uses measurements from EEG to regulate DOH on Bispectral Index by controlling infusion rate of Propofol. The performance of the controller is investigated and characterized with real dataset of 8 patients undergoing surgery. Results of this in silico study indicate that for all the patients, with 0% overshoot observed, the steady state error lies in between ±5. Clinically, this implies that in all the cases, without any overdose, the controller maintains the desired DOH level for smooth conduction of surgical procedures.
authors.affiliation: COMSATS Institute of Information Technology, Department of Electrical Engineering, Chak Shahzad, Paquistão.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Ilyas
authors.affiliation: COMSATS Institute of Information Technology, Department of Electrical Engineering, Chak Shahzad, Paquistão.
authors.forename: Ali
authors.initials: A
authors.lastname: Khaqan
authors.affiliation: National University of Computer and Emerging Sciences (FAST-NU), Department of Electrical Engineering, Islamabad, Paquistão. Electronic address: jamshed.iqbal@nu.edu.pk.
authors.forename: Jamshed
authors.initials: J
authors.lastname: Iqbal
authors.affiliation: COMSATS Institute of Information Technology, Department of Electrical Engineering, Chak Shahzad, Paquistão.
authors.forename: Raja Ali
authors.initials: RA
authors.lastname: Riaz
mesh_terms: D000328:Adult; D000771:Anesthesia, Intravenous / Q000379:methods*; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D007262:Infusions, Intravenous; D008297:Male; D008962:Models, Theoretical; D015742:Propofol / Q000008:administration & dosage*
chemical_list: D006993:Hypnotics and Sedatives; D015742:Propofol
keywords: Anestesia de circuito fechado; Biocontrol; Biocontrole; Closed‐loop anesthesia; Controle moderno; Farmacocinética; Farmacodinâmica; Modern control; Pharmacodynamics; Pharmacokinetics