title: NIR imaging-guided combined photodynamic therapy and chemotherapy by a pH-responsive amphiphilic polypeptide prodrug.
abstract: pH-Sensitive doxorubicin conjugated polymeric micelles entrapped with near infrared (NIR) photosensitizer BODIPY (which works as an imaging agent at the same time) were designed and synthesized by ring opening polymerization of N-carboxyanhydride with mPEG-NH2as the initiator, following reaction with doxorubicin to form the hydrazone-bond linker for pH responsiveness. Then the NIR dye (BODIPY) was loaded in the micelles for both bioimaging and photodynamic therapy (PDT). A significant cytotoxicity of NIR imaging-guided combined PDT and chemotherapy could be found by MTT assays, which was also confirmed with a fluorescence microscope, indicating a new kind of polymeric nanoparticle for potential theranostic treatment of cancers. In addition, the energy density of the laser for the PDT is extremely low.
authors.affiliation: CAS Key Laboratory of Soft Matter Chemistry, Hefei National Laboratory for Physical Sciences at the Microscale, iChEM, and Department of Chemical Physics, University of Science and Technology of China, Jinzai Road 96#, Hefei, 230026 Anhui, P.R. China. lfyan@ustc.edu.cn.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Ruan
authors.affiliation: CAS Key Laboratory of Soft Matter Chemistry, Hefei National Laboratory for Physical Sciences at the Microscale, iChEM, and Department of Chemical Physics, University of Science and Technology of China, Jinzai Road 96#, Hefei, 230026 Anhui, P.R. China. lfyan@ustc.edu.cn.
authors.forename: Le
authors.initials: L
authors.lastname: Liu
authors.affiliation: School of Life Sciences, University of Science and Technology of China, Hefei, 230027, Anhui, P.R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Jiang
authors.affiliation: School of Life Sciences, University of Science and Technology of China, Hefei, 230027, Anhui, P.R. China.
authors.forename: Shuya
authors.initials: S
authors.lastname: Li
authors.affiliation: School of Life Sciences, University of Science and Technology of China, Hefei, 230027, Anhui, P.R. China.
authors.forename: Yucai
authors.initials: Y
authors.lastname: Wang
authors.affiliation: CAS Key Laboratory of Soft Matter Chemistry, Hefei National Laboratory for Physical Sciences at the Microscale, iChEM, and Department of Chemical Physics, University of Science and Technology of China, Jinzai Road 96#, Hefei, 230026 Anhui, P.R. China. lfyan@ustc.edu.cn.
authors.forename: Lifeng
authors.identifier: http://orcid.org/0000-0002-6063-270X
authors.initials: L
authors.lastname: Yan
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D056945:Hep G2 Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy / Q000473:pathology; D051379:Mice; D008819:Mice, Nude; D010455:Peptides / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D010778:Photochemotherapy; D011355:Prodrugs / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D019265:Spectroscopy, Near-Infrared; D013501:Surface-Active Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D010455:Peptides; D011355:Prodrugs; D013501:Surface-Active Agents