title: Correlation of Kisspeptin-10 level and fetal well-being in preeclamptic patients.
abstract: OBJECTIVE
  This study aims to evaluate the role of kisspeptin-10 in preeclampsia and check for possible relationship between its severity and fetal growth well-being. Kisspeptin-10 may participate in implantation of the embryo, placenta formation, and maintenance of pregnancy.
  
  
  METHODS
  One hundred women who completed 20 weeks of gestation with singleton pregnancies were divided into 60 peeclamptic and 40 normotensive control women. Kisspeptin-10 level estimation, and ultrasound and Doppler ultrasound studies for umbilical artery were performed during their second and third trimesters of pregnancy.
  
  
  RESULTS
  Plasma kisspeptin-10 level was lower in preeclamptic groups and inversely correlated with the severity of the disease. Its level directly correlated with estimated fetal weight in utero during both trimesters in patients with severe preeclampsia and with fetal birth weight in patients with mild preeclampsia, whereas an inverse correlation was observed in those with severe preeclampsia during their second trimester. Kisspeptin-10 level was directly related to the resistance index in the second trimester in patients with severe preeclampsia, while it inversely correlated with the systolic/diastolic ratio and resistance index in the third trimester in patients with mild preeclampsia.
  
  
  CONCLUSIONS
  Kisspeptin-10 level is useful in assessing the severity of preeclampsia and can be a novel marker downregulated in pregnant women with preeclampsia, especially in those who also developed impaired uteroplacental perfusion or intrauterine growth restriction.
authors.affiliation: Al-Imamian Al-Kadhimyian Medical City, Al-Kharkh Health Director, Baghdad, Iraq.
authors.forename: Maysoun A
authors.initials: MA
authors.lastname: Ziyaraa
authors.affiliation: Department of Physiology, College of Medicine, Al-Nahrain University, Baghdad, Iraq. Electronic address: farqadbhamdan@colmed-alnahrain.edu.iq.
authors.forename: Farqad B
authors.initials: FB
authors.lastname: Hamdan
authors.affiliation: Department of Obstetrics & Gynecology, College of Medicine, Al-Nahrain University, Baghdad, Iraq.
authors.forename: Liqaa R
authors.initials: LR
authors.lastname: Mousa
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D047109:Fetal Development; D020567:Fetal Weight; D005865:Gestational Age; D006801:Humans; D059648:Kisspeptins / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D011446:Prospective Studies; D012720:Severity of Illness Index; D016216:Ultrasonography, Prenatal; D014469:Umbilical Arteries / Q000098:blood supply* / Q000000981:diagnostic imaging; D055815:Young Adult
chemical_list: D015415:Biomarkers; C106628:KISS1 protein, human; D059648:Kisspeptins
keywords: intrauterine growth restriction; kisspeptin-10; preeclampsia; pregnancy