title: [Lipids and cerebrovascular disease - New therapeutic options in lowering LDL-cholesterol].
abstract: Stroke is the third most common cause of death worldwide following myocardial infaction and malignancies, furthermore, its functional outcome is the worst of all conditions. Cholesterol, especially LDL-cholesterol plays a key role in the formation of atherosclerotic plaques. It has been verified recently that escalating incidence and mortality of cerebrovascular diseases are proportional to increased levels of LDL-cholesterol. Statin therapy undeniably reduces the risk of stroke, however other methods for decreasing lipid levels have not been proved significantly effective. Preventive effect of high-dose statin treatment is without doubt, although administration of such high dosage might require special precautions for patients with prior intracerebral hemorrhage and it also risks development of incident diabetes. The recently published IMPROVE-IT study is the first to prove that the addition of ezetimibe as a non-statin type drug, to statin treatment contributes to further reduction of LDL-cholesterol. The combination treatment results in additional decrease in the incidence and mortality of cerebrovascular events, without any expansion in the number or adverse effects. These results confirm the importance of any further reduction of LDL-cholesterol levels. Achieving target values with statin-ezetimibe combination allows administration of low to moderate dose of statin, which decreases risks of adverse effects related to high-dose statin therapy. Orv. Hetil., 2016, 157(52), 2059-2065.
authors.affiliation: Klinikai Központ, Neurológiai Klinika, Stroke Tanszék, Pécsi Tudományegyetem, Általános Orvostudományi Kar Pécs.
authors.forename: Emese
authors.initials: E
authors.lastname: Lovadi
authors.affiliation: Klinikai Központ, Neurológiai Klinika, Stroke Tanszék, Pécsi Tudományegyetem, Általános Orvostudományi Kar Pécs.
authors.forename: Péter
authors.initials: P
authors.lastname: Csécsei
authors.affiliation: Klinikai Központ, Neurológiai Klinika, Stroke Tanszék, Pécsi Tudományegyetem, Általános Orvostudományi Kar Pécs.
authors.forename: Csenge
authors.initials: C
authors.lastname: Lovig
authors.affiliation: Klinikai Központ, Neurológiai Klinika, Stroke Tanszék, Pécsi Tudományegyetem, Általános Orvostudományi Kar Pécs.
authors.forename: Zsófia
authors.initials: Z
authors.lastname: Karádi
authors.affiliation: Klinikai Központ, Neurológiai Klinika, Stroke Tanszék, Pécsi Tudományegyetem, Általános Orvostudományi Kar Pécs.
authors.forename: László
authors.initials: L
authors.lastname: Szapáry
mesh_terms: D000924:Anticholesteremic Agents / Q000008:administration & dosage*; D002318:Cardiovascular Diseases / Q000517:prevention & control*; D008078:Cholesterol, LDL / Q000097:blood* / Q000187:drug effects; D004359:Drug Therapy, Combination; D000069438:Ezetimibe / Q000008:administration & dosage*; D006801:Humans; D006949:Hyperlipidemias / Q000188:drug therapy*; D012308:Risk Management
chemical_list: D000924:Anticholesteremic Agents; D008078:Cholesterol, LDL; D000069438:Ezetimibe
keywords: LDL cholesterol; LDL-koleszterin; ezetimib; ezetimibe; statinok; statins; stroke