title: Aberrant spontaneous low-frequency brain activity in amnestic mild cognitive impairment: A meta-analysis of resting-state fMRI studies.
abstract: Recent resting-state functional magnetic resonance imaging (rs-fMRI) studies have provided strong evidence of abnormal spontaneous brain activity in amnestic mild cognitive impairment (aMCI). However, the conclusions have been inconsistent. A meta-analysis of whole-brain rs-fMRI studies that measured differences in the amplitude of low-frequency fluctuations (ALFF) between aMCI patients and healthy controls was conducted using the Seed-based d Mapping software package. Twelve studies reporting 14 datasets were included in the meta-analysis. Compared to healthy controls, patients with aMCI showed decreased ALFFs in the bilateral precuneus/posterior cingulate cortices, bilateral frontoinsular cortices, left occipitotemporal cortex, and right supramarginal gyrus and increased ALFFs in the right lingual gyrus, left middle occipital gyrus, left hippocampus, and left inferior temporal gyrus. A meta-regression analysis demonstrated that the increased severity of cognitive impairment in aMCI patients was associated with greater decreases in ALFFs in the cuneus/precuneus cortices. Our comprehensive meta-analysis suggests that aMCI is associated with widespread aberrant regional spontaneous brain activity, predominantly involving the default mode, salience, and visual networks, which contributes to understanding its pathophysiology.
authors.affiliation: Department of Neurology, Drum Tower Hospital of Nanjing Medical University, Nanjing, PR China; Department of Neurology, The Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng, PR China.
authors.forename: PingLei
authors.initials: P
authors.lastname: Pan
authors.affiliation: Department of Neurology, Drum Tower Hospital of Nanjing Medical University, Nanjing, PR China; Department of Neurology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, PR China; Department of Immunology, Nanjing Medical University, Nanjing, PR China; The State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, Jiangsu, PR China; Jiangsu Key Laboratory for Molecular Medicine, Nanjing University Medical School, Nanjing, Jiangsu, PR China; Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, PR China; Nanjing Neuropsychiatry Clinic Medical Center, Nanjing, PR China.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhu
authors.affiliation: Department of Neurology, Drum Tower Hospital of Nanjing Medical University, Nanjing, PR China; Department of Neurology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, PR China; Department of Immunology, Nanjing Medical University, Nanjing, PR China; The State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, Jiangsu, PR China; Jiangsu Key Laboratory for Molecular Medicine, Nanjing University Medical School, Nanjing, Jiangsu, PR China; Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, PR China; Nanjing Neuropsychiatry Clinic Medical Center, Nanjing, PR China.
authors.forename: TingTing
authors.initials: T
authors.lastname: Yu
authors.affiliation: Department of Neurology, The Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng, PR China.
authors.forename: HaiCun
authors.initials: H
authors.lastname: Shi
authors.affiliation: Department of Radiology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, PR China.
authors.forename: Bing
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Drum Tower Hospital of Nanjing Medical University, Nanjing, PR China; Department of Neurology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, PR China; The State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, Jiangsu, PR China; Jiangsu Key Laboratory for Molecular Medicine, Nanjing University Medical School, Nanjing, Jiangsu, PR China; Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, PR China; Nanjing Neuropsychiatry Clinic Medical Center, Nanjing, PR China.
authors.forename: Ruomeng
authors.initials: R
authors.lastname: Qin
authors.affiliation: Department of Neurology, Drum Tower Hospital of Nanjing Medical University, Nanjing, PR China; Department of Neurology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, PR China; The State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, Jiangsu, PR China; Jiangsu Key Laboratory for Molecular Medicine, Nanjing University Medical School, Nanjing, Jiangsu, PR China; Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, PR China; Nanjing Neuropsychiatry Clinic Medical Center, Nanjing, PR China.
authors.forename: Xiaolei
authors.initials: X
authors.lastname: Zhu
authors.affiliation: Department of Neurology, Drum Tower Hospital of Nanjing Medical University, Nanjing, PR China; Department of Neurology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, PR China; The State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, Jiangsu, PR China; Jiangsu Key Laboratory for Molecular Medicine, Nanjing University Medical School, Nanjing, Jiangsu, PR China; Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, PR China; Nanjing Neuropsychiatry Clinic Medical Center, Nanjing, PR China.
authors.forename: Lai
authors.initials: L
authors.lastname: Qian
authors.affiliation: Department of Neurology, Drum Tower Hospital of Nanjing Medical University, Nanjing, PR China; Department of Neurology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, PR China; The State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, Jiangsu, PR China; Jiangsu Key Laboratory for Molecular Medicine, Nanjing University Medical School, Nanjing, Jiangsu, PR China; Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, PR China; Nanjing Neuropsychiatry Clinic Medical Center, Nanjing, PR China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhao
authors.affiliation: Department of Immunology, Nanjing Medical University, Nanjing, PR China. Electronic address: hzhou@njmu.edu.cn.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhou
authors.affiliation: Department of Neurology, Drum Tower Hospital of Nanjing Medical University, Nanjing, PR China; Department of Neurology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, PR China; Department of Immunology, Nanjing Medical University, Nanjing, PR China; The State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, Jiangsu, PR China; Jiangsu Key Laboratory for Molecular Medicine, Nanjing University Medical School, Nanjing, Jiangsu, PR China; Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, PR China; Nanjing Neuropsychiatry Clinic Medical Center, Nanjing, PR China. Electronic address: xuyun20042001@aliyun.com.
authors.forename: Yun
authors.initials: Y
authors.lastname: Xu
mesh_terms: D000647:Amnesia / Q000175:diagnosis / Q000209:etiology; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods*; D060825:Cognitive Dysfunction / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male
keywords: Amnestic mild cognitive impairment; Amplitude of low-frequency fluctuations; Default mode network; Meta-analysis; Resting-state functional magnetic resonance imaging; Seed-based d mapping