title: In vitro and in vivo evaluation of in situ gelling systems for sustained topical ophthalmic delivery: state of the art and beyond.
abstract: In situ gelling delivery systems for the ocular administration of drugs has been a major focus of research over the past two decades, improving the treatment of diseases of the anterior segment of the eye by simple, safe, and reproducible drug administration. This drug delivery strategy results in high ocular bioavailability by avoiding rapid precorneal clearance resulting from nasolacrimal drainage and eye blinking. However, the development of such unconventional forms requires many parameters to be mastered, such as gelation time, viscoelastic behavior, mucoadhesion, and sustained release. In this review, we describe and assess the in vitro and in vivo methods available for in situ gelling ophthalmic delivery systems, highlighting the advantages of existing methods and, in some cases, the need for more relevant assays.
authors.affiliation: CNRS UMR 8258 (ex 8151) - Inserm U1022 - Chimie ParisTech, Paris Descartes University, 4 Av de L'Observatoire, Paris F-75006, France; Unither Développement Bordeaux, ZA Tech Espace, Av Toussaint Catros, Le Haillan F-33185, France.
authors.forename: Pierre-Louis
authors.initials: PL
authors.lastname: Destruel
authors.affiliation: Unither Pharmaceuticals, 41 Av de la Chaussée d'Antin, Paris F-75009, France.
authors.forename: Ni
authors.initials: N
authors.lastname: Zeng
authors.affiliation: Unither Pharmaceuticals, 41 Av de la Chaussée d'Antin, Paris F-75009, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Maury
authors.affiliation: CNRS UMR 8258 (ex 8151) - Inserm U1022 - Chimie ParisTech, Paris Descartes University, 4 Av de L'Observatoire, Paris F-75006, France. Electronic address: nathalie.mignet@parisdescartes.fr.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Mignet
authors.affiliation: CNRS UMR 8258 (ex 8151) - Inserm U1022 - Chimie ParisTech, Paris Descartes University, 4 Av de L'Observatoire, Paris F-75006, France; Mise au Point Galénique, Agence Générale des Equipements et Produits de Santé (AGEPS), AP-HP, 7 Rue du fer à Moulin, Paris F-75005, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Boudy
mesh_terms: D060433:Administration, Ophthalmic; D000818:Animals; D001682:Biological Availability; D003692:Delayed-Action Preparations / Q000008:administration & dosage* / Q000378:metabolism; D016503:Drug Delivery Systems / Q000379:methods; D005123:Eye / Q000187:drug effects*; D005782:Gels / Q000008:administration & dosage* / Q000378:metabolism; D006801:Humans; D009883:Ophthalmic Solutions / Q000008:administration & dosage / Q000378:metabolism
chemical_list: D003692:Delayed-Action Preparations; D005782:Gels; D009883:Ophthalmic Solutions