title: Heart targeted nanoliposomal/nanoparticles drug delivery: An updated review.
abstract: Nanoliposomes are type of nano-sized vesicles made of bi-layered phospholipid membranes with an aqueous interior. They have been demonstrated to deliver several materials like low molecular weight drugs, imaging agents, peptides, proteins, and nucleic acids. Nanoliposomes have been demonstrated to slowly release an encapsulated drug, thereby leading to sustained exposure to target region and improved efficacy. This ability of nano-liposomes can be harnessed to deliver therapeutic agents precisely to the infarcted heart. Accordingly, this article will review recent developments in the application of nano liposomes and nanoparticles as drug delivery systems to treat cardiovascular related disorders such as atherosclerosis, restenosis and myocardial infarction.
authors.affiliation: Department of Cardiology, Lorestan University of Medical Sciences, Khoramabad, Iran.
authors.forename: Mostafa
authors.initials: M
authors.lastname: Cheraghi
authors.affiliation: Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Babak
authors.initials: B
authors.lastname: Negahdari
authors.affiliation: Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran; Department of Medical Biotechnology, School of Medicine, Lorestan University of Medical sciences, Lorestan, Iran; Razi Herbal Medicine Research Center, Lorestan University of Medical Science, Iran.
authors.forename: Hadis
authors.initials: H
authors.lastname: Daraee
authors.affiliation: Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran; Department of Medical Biotechnology, School of Medicine, Lorestan University of Medical sciences, Lorestan, Iran; Razi Herbal Medicine Research Center, Lorestan University of Medical Science, Iran. Electronic address: a-eatemadi@razi.tums.ac.ir.
authors.forename: Ali
authors.initials: A
authors.lastname: Eatemadi
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000188:drug therapy; D003692:Delayed-Action Preparations / Q000008:administration & dosage; D016503:Drug Delivery Systems / Q000379:methods; D006321:Heart / Q000187:drug effects*; D006801:Humans; D008081:Liposomes / Q000008:administration & dosage*; D008970:Molecular Weight; D053758:Nanoparticles / Q000008:administration & dosage*; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*
chemical_list: D003692:Delayed-Action Preparations; D008081:Liposomes; D004364:Pharmaceutical Preparations
keywords: Atherosclerosis; Myocardial infarction; Nano-liposomes; Nanoparticles