title: Versatile Flexible Graphene Multielectrode Arrays.
abstract: Graphene is a promising material possessing features relevant to bioelectronics applications. Graphene microelectrodes (GMEAs), which are fabricated in a dense array on a flexible polyimide substrate, were investigated in this work for their performance via electrical impedance spectroscopy. Biocompatibility and suitability of the GMEAs for extracellular recordings were tested by measuring electrical activities from acute heart tissue and cardiac muscle cells. The recordings show encouraging signal-to-noise ratios of 65 ± 15 for heart tissue recordings and 20 ± 10 for HL-1 cells. Considering the low noise and excellent robustness of the devices, the sensor arrays are suitable for diverse and biologically relevant applications.
authors.affiliation: Institute of Bioelectronics (PGI-8/ICS-8), Forschungszentrum Jülich, 52425 Jülich, Germany. d.kireev@fz-juelich.de.
authors.forename: Dmitry
authors.initials: D
authors.lastname: Kireev
authors.affiliation: Institute of Bioelectronics (PGI-8/ICS-8), Forschungszentrum Jülich, 52425 Jülich, Germany. s.seyock@fz-juelich.de.
authors.forename: Silke
authors.initials: S
authors.lastname: Seyock
authors.affiliation: Institute of Bioelectronics (PGI-8/ICS-8), Forschungszentrum Jülich, 52425 Jülich, Germany. m.ernst@fz-juelich.de.
authors.forename: Mathis
authors.initials: M
authors.lastname: Ernst
authors.affiliation: Institute of Bioelectronics (PGI-8/ICS-8), Forschungszentrum Jülich, 52425 Jülich, Germany. v.maybeck@fz-juelich.de.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Maybeck
authors.affiliation: Institute of Bioelectronics (PGI-8/ICS-8), Forschungszentrum Jülich, 52425 Jülich, Germany. bernhard.wolfrum@tum.de.|Neuroelectronics, Munich School of Bioengineering, Technical University of Munich (TUM), Germany & BCCN Munich, Boltzmannstr. 11, 85748 Garching, Germany. bernhard.wolfrum@tum.de.
authors.forename: Bernhard
authors.initials: B
authors.lastname: Wolfrum
authors.affiliation: Institute of Bioelectronics (PGI-8/ICS-8), Forschungszentrum Jülich, 52425 Jülich, Germany. a.offenhaeusser@fz-jueluch.de.
authors.forename: Andreas
authors.initials: A
authors.lastname: Offenhäusser
mesh_terms: D000818:Animals; D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods; D002460:Cell Line; D002478:Cells, Cultured; D058266:Dielectric Spectroscopy; D006108:Graphite; D008839:Microelectrodes; D032383:Myocytes, Cardiac / Q000502:physiology; D051381:Rats
chemical_list: D006108:Graphite
keywords: GMEA; cell-graphene interface; extracellular recordings; graphene; graphene electrodes