title: Percutaneous CT-fluoroscopic-guided radioisotope seed placement for the management of adenoid cystic carcinoma of the trachea.
abstract: Tracheal and paratracheal malignancies present challenges in radiotherapeutic management due to their proximity to sensitive structures, central location, and because of the potential for catastrophic radiation induced fistula. The use of external beam radiation therapy and intraluminal brachytherapy has a limited number of reports in the literature. We have searched for a technique for treating tracheal and paratracheal malignancies allowing application of a high dose of radiation while minimizing dose to normal tissues. Our group has considerable experience in the use of percutaneous CT-guided radioisotope seed implants for intrathoracic malignancies. We have previously reported our technique for percutaneous CT-fluoroscopic-guided radioisotope seed implants in the management of thoracic malignancies. We have now treated several tracheal and paratracheal malignancies with our technique and report our results here. This is to our knowledge the first report of treatment of tracheal malignancy with CT-guided permanent seed implant.
  
  
  
  Three patients with tracheal adenoid cystic carcinoma were implanted with103Pd under CT-fluoroscopic guidance utilizing percutaneous approach.
  
  
  
  All patients tolerated the procedure well, and at 9-month average followup, all show disease regression, symptom improvement, and no sign of toxicity.
  
  
  
  We believe this to be the first published series on CT-directed permanent seed brachytherapy for tracheal malignancies. Review of PubMed literature to 1990 discloses no prior writings on the use of permanent seed implantation for tracheal cancers. Tracheal malignancies provide a vexing radiation therapy challenge to stay within the therapeutic window. CT-directed permanent seed brachytherapy allows a high dose to be delivered to the tumor with a rapid falloff to the surrounding tissues. Short-term results from seed implant are excellent. Our 3 patients responded well in the short term to permanent seed brachytherapy with no chronic side effects and with reduction or relief of cough and pain. CT-fluoro-guided permanent seed implantation is an effective and low morbidity treatment for tracheal malignancies. Long-term followup is needed to further elucidate durability of response and toxicity.
authors.affiliation: Radiation Oncology, Mission Regional Medical Center, Mission Viejo, CA. Electronic address: drdoggett@nocancer.com.
authors.forename: Stephen
authors.initials: S
authors.lastname: Doggett
authors.affiliation: Thoracic Surgery, Mission Regional Medical Center, Mission Viejo, CA.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Chino
authors.affiliation: Interventional Radiology, Mission Regional Medical Center, Mission Viejo, CA.
authors.forename: Todd
authors.initials: T
authors.lastname: Lempert
authors.affiliation: Interventional Radiology, Mission Regional Medical Center, Mission Viejo, CA.
authors.forename: Jay
authors.initials: J
authors.lastname: Federhart
mesh_terms: D000368:Aged; D001918:Brachytherapy / Q000379:methods*; D003528:Carcinoma, Adenoid Cystic / Q000532:radiotherapy*; D005260:Female; D005471:Fluoroscopy; D006801:Humans; D008297:Male; D008875:Middle Aged; D010165:Palladium / Q000627:therapeutic use*; D011868:Radioisotopes / Q000627:therapeutic use*; D015642:Radiology, Interventional; D061089:Radiotherapy, Image-Guided / Q000379:methods*; D014057:Tomography, X-Ray Computed; D014134:Tracheal Neoplasms / Q000532:radiotherapy*
chemical_list: D011868:Radioisotopes; D010165:Palladium; C000615531:Palladium-103
keywords: Adenoid cystic carcinoma; Brachytherapy; CT; Permanent seed; Trachea neoplasm