title: Polymorphisms of TGFβ1T+869C and C-509T with Lung Cancer Risk: A Meta-analysis.
abstract: BACKGROUND
  Lung cancer is the most common malignancy worldwide. A better understanding of the mechanisms may contribute to early diagnosis and establishment of new therapeutic targets.
  
  
  OBJECTIVE
  A meta-analysis was performed to investigate the association of transforming growth factor-beta 1 (TGFβ1) T+869C and C-509T polymorphisms with lung cancer susceptibility.
  
  
  METHODS
  Relevant studies were identified through PubMed, Medline, Embase and CNKI databases. The pooled odds ratios (ORs) with its 95% confidence intervals (CIs) were employed to assess these associations in a fixedor random-effects model.
  
  
  RESULTS
  For the TGFβ1 T+869C polymorphism, 5 published case-control studies with 1167 cases and 1365 controls were included. Overall, no significant association was found between the TGFβ1 T+869C polymorphism and lung cancer susceptibility under any genetic models in the total population (p > 0.05). A subgroup analysis by ethnicity showed no significant association among the Asian population as well, while a significant association was observed in Caucasian descendants. For the TGFβ1 C-509T polymorphism, 4 studies were considered, including 1029 cases and 1133 controls. However, this polymorphism also did not increase the risk of lung cancer in all genetic comparison models.
  
  
  CONCLUSIONS
  This meta-analysis suggests that TGFβ1 T+869C and C-509T polymorphisms may not contribute to lung cancer risk in the total population, while the T+869C polymorphism may increase the risk of lung cancer in the Caucasian population. However, many studies are still required to evaluate these associations in large populations.
authors.affiliation: Department of Microbiology, West China School of Preclinical and Forensic Medicine, Sichuan University.
authors.forename: Zhaomin
authors.initials: Z
authors.lastname: Deng
authors.affiliation: Department of Microbiology, West China School of Preclinical and Forensic Medicine, Sichuan University.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Microbiology, West China School of Preclinical and Forensic Medicine, Sichuan University.
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Huang
authors.affiliation: Department of Microbiology, West China School of Preclinical and Forensic Medicine, Sichuan University.
authors.forename: Yu
authors.initials: Y
authors.lastname: Kuang
authors.affiliation: Department of Microbiology, West China School of Preclinical and Forensic Medicine, Sichuan University.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Qin
authors.affiliation: Department of Microbiology, West China School of Preclinical and Forensic Medicine, Sichuan University.
authors.forename: Baoning
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Microbiology, West China School of Preclinical and Forensic Medicine, Sichuan University.
authors.forename: Hongren
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Microbiology, West China School of Preclinical and Forensic Medicine, Sichuan University.
authors.forename: Mingyuan
authors.initials: M
authors.lastname: Li
mesh_terms: D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias; D012307:Risk Factors; D053773:Transforming Growth Factor beta1 / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D053773:Transforming Growth Factor beta1
keywords: lung cancer; meta-analysis; polymorphism; transforming growth factor-beta 1