title: Coupling 1D modifications and 3D nuclear organization: data, models and function.
abstract: Over the past decade, advances in molecular methods have strikingly improved the resolution at which nuclear genome folding can be analyzed. This revealed a wealth of conserved features organizing the one dimensional DNA molecule into tridimensional nuclear domains. In this review, we briefly summarize the main findings and highlight how models based on polymer physics shed light on the principles underlying the formation of these domains. Finally, we discuss the mechanistic similarities allowing self-organization of these structures and the functional importance of these in the maintenance of transcriptional programs.
authors.affiliation: University Grenoble Alpes, CNRS, TIMC-IMAG lab, UMR 5525, Grenoble, F-38706 La Tronche, France.
authors.forename: Daniel
authors.initials: D
authors.lastname: Jost
authors.affiliation: Univ Lyon, ENS de Lyon, Univ Claude Bernard, CNRS, Laboratoire de Physique, F-69007 Lyon, France.
authors.forename: Cédric
authors.initials: C
authors.lastname: Vaillant
authors.affiliation: Cell Fate and Nuclear Organization, Institute of Cell Biology, University of Bern, CH-3012 Bern, Switzerland. Electronic address: peter.meister@izb.unibe.ch.
authors.forename: Peter
authors.initials: P
authors.lastname: Meister
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000737:chemistry*; D002843:Chromatin / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D005786:Gene Expression Regulation; D016678:Genome; D006801:Humans; D008958:Models, Molecular
chemical_list: D002843:Chromatin; D004247:DNA