title: The central nervous system microenvironment influences the leukemia transcriptome and enhances leukemia chemo-resistance.
authors.affiliation: Department of Pediatrics, Division of Pediatric Hematology and Oncology, University of Minnesota Masonic Cancer Center, Minneapolis, MN, USA.
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Gaynes
authors.affiliation: Department of Pediatrics, Division of Pediatric Hematology and Oncology, University of Minnesota Masonic Cancer Center, Minneapolis, MN, USA.
authors.forename: Leslie M
authors.initials: LM
authors.lastname: Jonart
authors.affiliation: Department of Pediatrics, Division of Pediatric Hematology and Oncology, University of Minnesota Masonic Cancer Center, Minneapolis, MN, USA.
authors.forename: Edward A
authors.initials: EA
authors.lastname: Zamora
authors.affiliation: Department of Pediatrics, Division of Pediatric Hematology and Oncology, University of Minnesota Masonic Cancer Center, Minneapolis, MN, USA.
authors.forename: Jordan A
authors.initials: JA
authors.lastname: Naumann
authors.affiliation: Department of Pediatrics, Division of Pediatric Hematology and Oncology, University of Minnesota Masonic Cancer Center, Minneapolis, MN, USA.
authors.forename: Nathan P
authors.initials: NP
authors.lastname: Gossai
authors.affiliation: Department of Pediatrics, Division of Pediatric Hematology and Oncology, University of Minnesota Masonic Cancer Center, Minneapolis, MN, USA gord0047@umn.edu.
authors.forename: Peter M
authors.initials: PM
authors.lastname: Gordon
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D001854:Bone Marrow Cells / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D002490:Central Nervous System / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D018920:Coculture Techniques; D003561:Cytarabine / Q000494:pharmacology; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D015973:Gene Expression Regulation, Leukemic; D006801:Humans; D051379:Mice; D016688:Mice, Inbred NOD; D009363:Neoplasm Proteins / Q000235:genetics* / Q000378:metabolism; D009368:Neoplasm Transplantation; D009474:Neurons / Q000378:metabolism / Q000473:pathology; D000075062:Pre-B-Cell Leukemia Transcription Factor 1 / Q000235:genetics / Q000378:metabolism; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D012008:Recurrence; D015398:Signal Transduction; D059467:Transcriptome; D014183:Transplantation, Heterologous; D059016:Tumor Microenvironment / Q000235:genetics
chemical_list: D000970:Antineoplastic Agents; D009363:Neoplasm Proteins; D000075062:Pre-B-Cell Leukemia Transcription Factor 1; C083400:PBX1 protein, human; D003561:Cytarabine