title: Interrogating cellular perception and decision making with optogenetic tools.
abstract: Optogenetics promises to deepen our understanding of how cells perceive and respond to complex and dynamic signals and how this perception regulates normal and abnormal function. In this study, we present our vision for how these nascent tools may transform our view of fundamental cell biological processes.
authors.affiliation: Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158.
authors.forename: Lukasz J
authors.initials: LJ
authors.lastname: Bugaj
authors.affiliation: Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158.
authors.forename: Geoff P
authors.initials: GP
authors.lastname: O'Donoghue
authors.affiliation: Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158 wendell.lim@ucsf.edu.|Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158.|Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158.|Center for Systems and Synthetic Biology, University of California, San Francisco, San Francisco, CA 94158.
authors.forename: Wendell A
authors.initials: WA
authors.lastname: Lim
mesh_terms: D000818:Animals; D003585:Cell Biology / Q000639:trends*; D004059:Diffusion of Innovation; D005544:Forecasting; D053263:Gene Regulatory Networks; D006801:Humans; D062308:Optogenetics / Q000639:trends*; D060066:Protein Interaction Maps; D015398:Signal Transduction