title: En bloc kidney transplantation from infant donors younger than 10 months into pediatric recipients.
abstract: Early graft loss and poor graft function limit the use of kidneys from infant donors. Six en bloc kidney transplantations were performed from infant donors younger than 10 months into pediatric recipients between November 2012 and September 2015 at our center. We retrospectively analyzed recipient and donor demographics, surgery procedures, complications, graft function and size, and patient and graft survival with a follow-up of 6-39 months (median 15.5 months). Donor age ranged from 1 to 10 months with weight ranging from 3.5 to 10 kg. Recipient age ranged from 10 to 16 years with weight ranging from 30 to 39 kg. One kidney was removed due to arterial thrombosis during surgery, while the other kidney of this en bloc graft remained viable. Urine leak followed by bilateral ureteral obstruction occurred in one recipient. All of the recipients showed immediate graft function. The size of the en bloc kidney increased from 4.2±0.6 cm to 7.6±0.6 cm 6 months after surgery. Patient and graft survival were both 100% at the last follow-up. Our results show that en bloc kidney transplantation from infant donors younger than 10 months into pediatric recipients is effective under the condition of experienced surgical techniques and perioperative management.
authors.affiliation: Organ Transplantation Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Hong-Yang
authors.initials: HY
authors.lastname: Wang
authors.affiliation: Organ Transplantation Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.affiliation: Organ Transplantation Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Long-Shan
authors.initials: LS
authors.lastname: Liu
authors.affiliation: Organ Transplantation Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Rong-Hai
authors.initials: RH
authors.lastname: Deng
authors.affiliation: Organ Transplantation Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Fu
authors.affiliation: Department of Urology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: Dicken Shiu-Chung
authors.initials: DS
authors.lastname: Ko
authors.affiliation: Organ Transplantation Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Huan-Xi
authors.initials: HX
authors.lastname: Zhang
authors.affiliation: Organ Transplantation Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Su-Xiong
authors.initials: SX
authors.lastname: Deng
authors.affiliation: Organ Transplantation Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.|Guangdong Provincial Key Laboratory on Organ Donation and Transplant Immunology, Guangzhou, China.
authors.forename: Chang-Xi
authors.initials: CX
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D001158:Arteries / Q000503:physiopathology; D001835:Body Weight; D002648:Child; D005260:Female; D005919:Glomerular Filtration Rate; D006085:Graft Survival; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007223:Infant; D007231:Infant, Newborn; D016030:Kidney Transplantation / Q000379:methods*; D008297:Male; D051437:Renal Insufficiency / Q000601:surgery*; D012189:Retrospective Studies; D013927:Thrombosis / Q000209:etiology; D014019:Tissue Donors; D016896:Treatment Outcome; D014517:Ureteral Obstruction / Q000209:etiology
chemical_list: D007166:Immunosuppressive Agents
keywords: en bloc kidney transplantation; infant donors; outcome; pediatric; surgical procedures