title: JC polyomavirus nephropathy, a rare cause of transplant dysfunction: Case report and review of literature.
abstract: JC polyomavirus-associated nephropathy (JC-PVAN) is a rare but challenging cause of renal dysfunction. We report JC-PVAN in a renal allograft recipient and highlight the obstacles in definitive diagnosis of this disease entity. A deceased-donor renal transplant recipient was diagnosed with JC polyomavirus nephritis 4 years after transplantation. Immunosuppressive agents were subsequently reduced, resulting in an initial stabilization of renal function. We present this interesting case and discuss the challenges with diagnosing and treating this rare entity.
authors.affiliation: Department of Surgery, Albany Medical College, Albany, NY, USA.
authors.forename: Doyle
authors.initials: D
authors.lastname: Yang
authors.affiliation: Department of Surgery, Albany Medical College, Albany, NY, USA.
authors.forename: Brandon
authors.initials: B
authors.lastname: Keys
authors.affiliation: Division of Surgery, Section of Transplantation, Albany Medical Center, Albany, NY, USA.
authors.forename: David
authors.initials: D
authors.lastname: J Conti
authors.affiliation: Division of Pathology, Albany Medical Center, Albany, NY, USA.
authors.forename: Llewellyn
authors.initials: L
authors.lastname: Foulke
authors.affiliation: Center for Immunology and Microbial Diseases, Albany Medical College, Albany, NY, USA.
authors.forename: Kathleen
authors.initials: K
authors.lastname: Stellrecht
authors.affiliation: Department of Laboratory Medicine, University of Washington, Seattle, WA, USA.
authors.forename: Linda
authors.initials: L
authors.lastname: Cook
authors.affiliation: Division of Surgery, Section of Transplantation, Albany Medical Center, Albany, NY, USA.
authors.forename: Reynold I
authors.initials: RI
authors.lastname: Lopez-Soler
mesh_terms: D001739:BK Virus / Q000302:isolation & purification / Q000472:pathogenicity; D001706:Biopsy; D003404:Creatinine / Q000097:blood; D006084:Graft Rejection / Q000188:drug therapy / Q000473:pathology / Q000821:virology*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage / Q000627:therapeutic use; D007165:Immunosuppression Therapy / Q000009:adverse effects; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D015994:Incidence; D007555:Isoxazoles / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D007577:JC Virus / Q000302:isolation & purification* / Q000472:pathogenicity; D007676:Kidney Failure, Chronic / Q000601:surgery; D007677:Kidney Function Tests; D016030:Kidney Transplantation / Q000009:adverse effects*; D000077339:Leflunomide; D008297:Male; D008875:Middle Aged; D009173:Mycophenolic Acid / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D009393:Nephritis / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology / Q000821:virology*; D016133:Polymerase Chain Reaction; D027601:Polyomavirus Infections / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology / Q000821:virology*; D020123:Sirolimus / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D016559:Tacrolimus / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D014184:Transplantation, Homologous / Q000009:adverse effects; D014766:Viremia / Q000175:diagnosis / Q000453:epidemiology / Q000821:virology*
chemical_list: D016756:Immunoglobulins, Intravenous; D007166:Immunosuppressive Agents; D007555:Isoxazoles; D003404:Creatinine; D000077339:Leflunomide; D009173:Mycophenolic Acid; D020123:Sirolimus; D016559:Tacrolimus
keywords: JC virus; nephropathy; polyomavirus; renal transplant