title: sm"FISH"ing for Hedgehog.
abstract: Patched (Ptch) receptors are critical negative regulators of Hedgehog signaling, where Ptch1 loss causes basal cell carcinoma and Ptch1;Ptch2 loss disrupts skin and hair follicle development. Adolphe et al. use single molecule fluorescent in situ hybridization to show quantitatively that Ptch receptors create a Hedgehog signaling gradient that may specify hair follicle development.
authors.affiliation: Department of Developmental and Cell Biology, University of California, Irvine, Irvine, California, USA.
authors.forename: Michael L
authors.initials: ML
authors.lastname: Drummond
authors.affiliation: Department of Developmental and Cell Biology, University of California, Irvine, Irvine, California, USA; Chao Family Comprehensive Cancer Center, University of California, Irvine, Irvine, California, USA. Electronic address: satwood@uci.edu.
authors.forename: Scott X
authors.initials: SX
authors.lastname: Atwood
mesh_terms: D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D004351:Drug Resistance / Q000235:genetics; D006201:Hair Diseases / Q000235:genetics / Q000473:pathology; D018859:Hair Follicle / Q000254:growth & development; D053823:Hedgehog Proteins / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D000072079:Patched Receptors / Q000235:genetics*; D015398:Signal Transduction; D012878:Skin Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology
chemical_list: D053823:Hedgehog Proteins; D000072079:Patched Receptors