title: Non-coding RNAs as antibiotic targets.
abstract: Antibiotics inhibit a wide range of essential processes in the bacterial cell, including replication, transcription, translation and cell wall synthesis. In many instances, these antibiotics exert their effects through association with non-coding RNAs. This review highlights many classical antibiotic targets (e.g. rRNAs and the ribosome), explores a number of emerging targets (e.g. tRNAs, RNase P, riboswitches and small RNAs), and discusses the future directions and challenges associated with non-coding RNAs as antibiotic targets.
authors.affiliation: Department of Biology and Institute for Infectious Disease Research, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4K1, Canada.
authors.forename: Savannah
authors.initials: S
authors.lastname: Colameco
authors.affiliation: Department of Biology and Institute for Infectious Disease Research, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4K1, Canada. Electronic address: melliot@mcmaster.ca.
authors.forename: Marie A
authors.initials: MA
authors.lastname: Elliot
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000378:metabolism*; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D012343:RNA, Transfer / Q000235:genetics / Q000378:metabolism*; D022661:RNA, Untranslated / Q000235:genetics / Q000378:metabolism*; D058928:Riboswitch / Q000187:drug effects / Q000502:physiology
chemical_list: D000900:Anti-Bacterial Agents; D022661:RNA, Untranslated; D058928:Riboswitch; D012343:RNA, Transfer
keywords: Antibiotic; Non-coding RNA; Ribosome; Riboswitch; tRNA