title: Sinusoidal CD30+ diffuse large B-cell lymphoma can masquerade as anaplastic large cell lymphoma in pediatric posttransplant lymphoproliferative disorders.
abstract: Posttransplant lymphoproliferative disorder (PTLD) is a known complication of solid organ transplantation. Diffuse large B-cell lymphoma (DLBCL) is frequently seen in this setting. However, CD30+ DLBCL with sinusoidal pattern of involvement has not been reported in pediatric PTLD. We are reporting a 9-year-old female child presented with diffuse lymphadenopathy postheart transplantation. The pattern of involvement was suggestive of anaplastic large cell lymphoma, but the malignant cells were positive for B-cell markers and negative for anaplastic lymphoma kinase. The patient was treated aggressively with multiagent chemotherapy and rituximab. Accurate diagnosis in PTLD is paramount in making management decisions.
authors.affiliation: Department of Pediatric Hematology/Oncology/BMT, Medical College of Wisconsin, Milwaukee, Wisconsin.
authors.forename: Neel S
authors.initials: NS
authors.lastname: Bhatt
authors.affiliation: Department of Pediatric Hematology/Oncology/BMT, Medical College of Wisconsin, Milwaukee, Wisconsin.
authors.forename: Michael E
authors.initials: ME
authors.lastname: Kelly
authors.affiliation: Department of Pathology, Children's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, Wisconsin.
authors.forename: Bjorn
authors.initials: B
authors.lastname: Batdorf
authors.affiliation: Department of Pathology, Children's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, Wisconsin.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Gheorghe
mesh_terms: D002648:Child; D003937:Diagnosis, Differential; D020031:Epstein-Barr Virus Infections / Q000150:complications; D005260:Female; D016027:Heart Transplantation / Q000009:adverse effects; D006801:Humans; D007150:Immunohistochemistry; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000209:etiology; D017728:Lymphoma, Large-Cell, Anaplastic / Q000175:diagnosis*; D008232:Lymphoproliferative Disorders / Q000150:complications; D011183:Postoperative Complications / Q000175:diagnosis*
keywords: diffuse large B-cell lymphoma; posttransplant lymphoproliferative disorder; solid organ transplantation