title: Portal Vein Stenting Combined with Iodine-125 Seeds Endovascular Implantation Followed by Transcatheter Arterial Chemoembolization for Treatment of Hepatocellular Carcinoma Patients with Portal Vein Tumor Thrombus.
abstract: Aim was to assess the therapeutic value of portal vein stenting (PVS) combined with iodine-125 seed (125I seed) strand endovascular implantation followed by transcatheter arterial chemoembolization (TACE) for treating patients with hepatocellular carcinoma (HCC) and portal vein tumor thrombus (PVTT). This was a retrospective study of 34 patients aged 29-81 years, diagnosed HCC with PVTT, and treated with PVS combined with125I seed strand endovascular implantation followed by TACE between January 2012 and August 2014. Survival, stent patency, technical success rate, complications related to the procedure, and adverse events were recorded. The technical success rate was 100%. No serious procedure-related adverse event was recorded. The median survival was 147 days. The cumulative survival rates and stent patency rates at 90, 180, and 360 days were 94.1%, 61.8%, and 32.4% and 97.1% (33/34), 76.9% (24/34), and 29.4% (10/34), respectively. PVS combined with125I seed strand endovascular implantation followed by TACE is feasible for patients with HCC and PVTT. It resulted in appropriate survival and stent patency, with no procedure-related adverse effects.
authors.affiliation: Department of Hepatobiliary and Pancreatic Interventional Center, The First Affiliated Hospital, School of Medicine, Zhejiang University and Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, Zhejiang 310003, China.
authors.forename: Jun-Hui
authors.identifier: 0000-0003-1947-8330
authors.initials: JH
authors.lastname: Sun
authors.affiliation: Department of Hepatobiliary and Pancreatic Interventional Center, The First Affiliated Hospital, School of Medicine, Zhejiang University and Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, Zhejiang 310003, China.
authors.forename: Tanyang
authors.initials: T
authors.lastname: Zhou
authors.affiliation: Department of Hepatobiliary and Pancreatic Interventional Center, The First Affiliated Hospital, School of Medicine, Zhejiang University and Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, Zhejiang 310003, China.
authors.forename: Tongyin
authors.initials: T
authors.lastname: Zhu
authors.affiliation: Department of Hepatobiliary and Pancreatic Interventional Center, The First Affiliated Hospital, School of Medicine, Zhejiang University and Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, Zhejiang 310003, China.
authors.forename: Yuelin
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Hepatobiliary and Pancreatic Interventional Center, The First Affiliated Hospital, School of Medicine, Zhejiang University and Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, Zhejiang 310003, China.
authors.forename: Chunhui
authors.initials: C
authors.lastname: Nie
authors.affiliation: Department of Ophthalmology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310009, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Ai
authors.affiliation: Department of Hepatobiliary and Pancreatic Interventional Center, The First Affiliated Hospital, School of Medicine, Zhejiang University and Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, Zhejiang 310003, China.
authors.forename: Guanhui
authors.initials: G
authors.lastname: Zhou
authors.affiliation: Department of Hepatobiliary and Pancreatic Interventional Center, The First Affiliated Hospital, School of Medicine, Zhejiang University and Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, Zhejiang 310003, China.
authors.forename: Aibin
authors.initials: A
authors.lastname: Zhang
authors.affiliation: Department of Nuclear Medicine, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China.
authors.forename: Meng-Jie
authors.initials: MJ
authors.lastname: Dong
authors.affiliation: Department of Hepatobiliary and Pancreatic Interventional Center, The First Affiliated Hospital, School of Medicine, Zhejiang University and Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, Zhejiang 310003, China.
authors.forename: Wei-Lin
authors.initials: WL
authors.lastname: Wang
authors.affiliation: Department of Hepatobiliary and Pancreatic Interventional Center, The First Affiliated Hospital, School of Medicine, Zhejiang University and Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, Zhejiang 310003, China.
authors.forename: Shu-Sen
authors.identifier: 0000-0003-1459-8261
authors.initials: SS
authors.lastname: Zheng
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000401:mortality / Q000628:therapy; D002404:Catheterization; D016461:Chemoembolization, Therapeutic / Q000379:methods*; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007457:Iodine Radioisotopes / Q000008:administration & dosage*; D008113:Liver Neoplasms / Q000401:mortality / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011169:Portal Vein / Q000601:surgery*; D012189:Retrospective Studies; D015607:Stents; D015996:Survival Rate; D020246:Venous Thrombosis / Q000401:mortality / Q000628:therapy
chemical_list: D007457:Iodine Radioisotopes