title: The distress thermometer as a predictor for survival in stage III lung cancer patients treated with chemotherapy.
abstract: BACKGROUND
  Depression and Health Related Quality of Life have been associated with prognosis in lung cancer. As the Distress Thermometer measures emotional problems and may share similarities with aspects of Health Related Quality of Life, we aimed to retrospectively assess the prognostic value of the Distress Thermometer in lung cancer patients treated with chemotherapy.
  
  
  METHODS
  Patients with stage III lung cancer who were treated at the day-care oncology unit with chemotherapy containing carboplatin from 2009 to 2014 and in whom a Distress Thermometer was performed at the time of the first cycle of chemotherapy were included in this study.
  
  
  RESULTS
  In total, one hundred and thirteen patients were included in the analysis. In the simple Cox regression analysis, overall survival did not significantly differ according to Distress Thermometer score. No significant differences in Distress Thermometer score according to stage, histology, (intended) treatment, age, sex, and comorbidity were observed. Also in a multivariable model the Distress Thermometer was not prognostic for overall survival, whereas sex and (intended) treatment was.
  
  
  CONCLUSIONS
  In this study no prognostic value of the Distress Thermometer could be established in patients with stage III lung cancer treated with carboplatin. Further research is warranted to address this issue.
authors.affiliation: Department of Pulmonary Medicine, Erasmus University Medical Centre, Rotterdam, The Netherlands.|Department of Pulmonary Medicine, Amphia Hospital, Breda, The Netherlands.
authors.forename: Mark
authors.initials: M
authors.lastname: de Mol
authors.affiliation: Department of Medical and Clinical Psychology, Centre of Research on Psychological and Somatic Disorders (CoRPS), Tilburg University, Tilburg, The Netherlands.
authors.forename: Brenda L
authors.initials: BL
authors.lastname: den Oudsten
authors.affiliation: Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht, The Netherlands.
authors.forename: Mieke
authors.initials: M
authors.lastname: Aarts
authors.affiliation: Department of Pulmonary Medicine, Erasmus University Medical Centre, Rotterdam, The Netherlands.|Department of Pulmonary Medicine, Amphia Hospital, Breda, The Netherlands.
authors.forename: Joachim G J V
authors.initials: JGJV
authors.lastname: Aerts
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003863:Depression; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000401:mortality* / Q000473:pathology / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D016016:Proportional Hazards Models; D011788:Quality of Life; D012189:Retrospective Studies; D013315:Stress, Psychological
keywords: cancer; chemotherapy; distress thermometer; health related quality of life; survival