title: Integrative Characterization of Toxic Response of Zebra Fish(Danio rerio)to Deltamethrin Based on AChE Activity and Behavior Strength.
abstract: In order to characterize the toxic response of zebra fish (Danio rerio) to Deltamethrin (DM), behavior strength (BS) and muscle AChE activity of zebra fish were investigated. The results showed that the average values of both BS and AChE activity showed a similarly decreased tendency as DM concentration increased, which confirmed the dose-effect relationship, and high and low levels of AChE and BS partly matched low and high levels of exposure concentrations in self-organizing map. These indicated that AChE and BS had slight different aspects of toxicity although overall trend was similar. Behavior activity suggested a possibility of reviving circadian rhythm in test organisms after exposure to the chemical in lower concentration (0.1 TU). This type of rhythm disappeared in higher concentrations (1.0 TU and 2.0 TU). Time series trend analysis of BS and AChE showed an evident time delayed effect of AChE, and a 2 h AChE inhibition delay with higher correlation coefficients (r) in different treatments was observed. It was confirmed that muscle AChE inhibition of zebra fish is a factor for swimming behavior change, though there was a 2 h delay, and other factors should be investigated to illustrate the detailed behavior response mechanism.
authors.affiliation: Institute of Environment and Ecology, Shandong Normal University, Ji'nan 250014, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Ren
authors.affiliation: Institute of Environment and Ecology, Shandong Normal University, Ji'nan 250014, China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Institute of Environment and Ecology, Shandong Normal University, Ji'nan 250014, China.
authors.forename: Shangge
authors.initials: S
authors.lastname: Li
authors.affiliation: Institute of Environment and Ecology, Shandong Normal University, Ji'nan 250014, China.
authors.forename: Zongming
authors.identifier: 0000-0001-5396-7272
authors.initials: Z
authors.lastname: Ren
authors.affiliation: Institute of Environment and Ecology, Shandong Normal University, Ji'nan 250014, China.
authors.forename: Meiyi
authors.initials: M
authors.lastname: Yang
authors.affiliation: Institute of Environment and Ecology, Shandong Normal University, Ji'nan 250014, China.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Pan
authors.affiliation: Institute of Environment and Ecology, Shandong Normal University, Ji'nan 250014, China.
authors.forename: Shiguo
authors.initials: S
authors.lastname: Xu
authors.affiliation: Management College, Ocean University of China, Qingdao 266100, China.
authors.forename: Li
authors.initials: L
authors.lastname: Qi
authors.affiliation: Department of Biological Sciences, Pusan National University, Busan 609735, Republic of Korea; Ecology and Future Research Association, Busan 609802, Republic of Korea.
authors.forename: Tae-Soo
authors.initials: TS
authors.lastname: Chon
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D009570:Nitriles / Q000633:toxicity*; D011722:Pyrethrins / Q000633:toxicity*; D013997:Time Factors; D015027:Zebrafish / Q000378:metabolism*; D029961:Zebrafish Proteins / Q000378:metabolism*
chemical_list: D009570:Nitriles; D011722:Pyrethrins; D029961:Zebrafish Proteins; C017180:decamethrin; D000110:Acetylcholinesterase