title: Extra-acral cutaneous sclerosing perineurioma with CD34 fingerprint pattern.
abstract: Sclerosing perineuroma is a variant of extraneural perineurioma that, as a rule, occurs in acral sites. However, it has also been occasionally reported in non-acral regions. Recently, CD34 expression in a pattern reminiscent of the human fingerprint has been observed in a subset of perineuriomas, but this immunohistochemical finding has not been documented in non-acral sclerosing perineuriomas. We report a case of sclerosing perineurioma presenting CD34 expression in a fingerprint-like pattern on the skin of the neck (a previously unreported site for this neoplasm) of a 56-year-old man. In addition, alpha smooth-muscle actin showed a similar pattern of expression, suggesting that the cell population implicated in the remarkable immunolabeling is most probably fibroblastic/myofibroblastic. Other immunohistochemical findings included epithelial membrane antigen and claudin1-positive lesional cells, and the absence of S100, glucose transporter protein 1, MUC4 and desmin.
authors.affiliation: Hospital Israelita Albert Einstein, Pathology Department and Instituto do Cancer do Estado de São Paulo (ICESP), Anatomic Pathology Division, São Paulo, Brazil.
authors.forename: Ricardo S
authors.identifier: http://orcid.org/0000-0002-4140-4998
authors.initials: RS
authors.lastname: Macarenco
authors.affiliation: Dermatology Department, Instituto do Cancer do Estado de São Paulo (ICESP), São Paulo, Brazil.
authors.forename: Jade
authors.initials: J
authors.lastname: Cury-Martins
mesh_terms: D018952:Antigens, CD34 / Q000378:metabolism*; D006258:Head and Neck Neoplasms / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000378:metabolism*; D018317:Nerve Sheath Neoplasms / Q000378:metabolism / Q000473:pathology; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology
chemical_list: D018952:Antigens, CD34; D009363:Neoplasm Proteins
keywords: CD34 fingerprint; cutaneous perineurioma; dermoscopy; fibroblast; sclerosing perineurioma