title: Effect of intrahepatic cholestasis of pregnancy on maternal serum screening tests.
abstract: OBJECTIVE
  In this study, we aimed to evaluate whether the changes in the first and second trimester maternal serum biochemical markers used for prenatal screening are associated with euploid pregnancies complicated by intrahepatic cholestasis of pregnancy (ICP).
  
  
  METHODS
  A total of 94 pregnant women were included in this retrospective comparative study. Thirty-seven women whose pregnancy was complicated with ICP constituted the study group whereas 57 of them constituted the control group. All hospital records were examined in terms of combined first trimester screening test and second trimester triple test parameters. Perinatal outcomes were also recorded.
  
  
  RESULTS
  No significant difference was observed between the two groups in term of age, BMI, and obstetric history (all p > 0.05). Mean serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and serum bile acid concentrations in the study group were significantly higher than in the controls (p < 0.001). There were no significant differences between the two groups in terms of first and second trimester serum biochemical markers. Newborn gender, route of birth, and NICU admission rates were also similar in the two groups. Mean birth weight of the control group was statistically significantly higher than the ICP group (p = 0.012).
  
  
  CONCLUSIONS
  We report no significant differences between pregnancies complicated by ICP and healthy pregnancies in terms of first and second trimester maternal serum screening test results.
authors.forename: G G
authors.initials: GG
authors.lastname: Türkmen
authors.forename: H
authors.initials: H
authors.lastname: Timur
authors.forename: Z
authors.initials: Z
authors.lastname: Yilmaz
authors.forename: A
authors.initials: A
authors.lastname: Kirbas
authors.forename: K
authors.initials: K
authors.lastname: Daglar
authors.forename: A
authors.initials: A
authors.lastname: Tokmak
authors.forename: D
authors.initials: D
authors.lastname: Uygur
authors.forename: N
authors.initials: N
authors.lastname: Danişman
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000378:metabolism; D001219:Aspartate Aminotransferases / Q000378:metabolism; D001647:Bile Acids and Salts / Q000378:metabolism; D016022:Case-Control Studies; D002780:Cholestasis, Intrahepatic / Q000378:metabolism*; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000378:metabolism*; D004964:Estriol / Q000378:metabolism*; D005260:Female; D006801:Humans; D062145:Maternal Serum Screening Tests; D048208:Nuchal Translucency Measurement; D011247:Pregnancy; D011248:Pregnancy Complications / Q000378:metabolism*; D011266:Pregnancy-Associated Plasma Protein-A / Q000378:metabolism*; D012189:Retrospective Studies; D000509:alpha-Fetoproteins / Q000378:metabolism*
chemical_list: D001647:Bile Acids and Salts; D018997:Chorionic Gonadotropin, beta Subunit, Human; D000509:alpha-Fetoproteins; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D011266:Pregnancy-Associated Plasma Protein-A; D004964:Estriol
keywords: Maternal serum screening tests; intrahepatic cholestasis; perinatal outcome; pregnancy