title: Autologous blood preparations rich in platelets, fibrin and growth factors.
abstract: OBJECTIVE
  Bone regeneration is often needed prior to dental implant treatment due to the lack of adequate quantity and quality after infectious diseases. The greatest regenerative power was obtained with autologous tissue, primarily the bone alive, taken from the same site or adjacent sites, up to the use centrifugation of blood with the selection of the parts with the greatest potential regenerative. In fact, various techniques and technologies were chronologically successive to cope with an ever better preparation of these concentrates of blood. Our aim is to review these advances and discuss the ways in which platelet concentrates may provide such unexpected beneficial therapeutic effects.
  
  
  METHODS
  The research has been carried out in the MEDLINE and Cochrane Central Register of Controlled Trials database by choosing keywords as "platelet rich plasma", "platelet rich fibrin", "platelet growth factors", and "bone regeneration" and "dentistry".
  
  
  RESULTS
  Autologous platelet rich plasma is a safe and low cost procedure to deliver growth factors for bone and soft tissue healing.
  
  
  CONCLUSIONS
  The great heterogeneity of clinical outcomes can be explained by the different PRP products with qualitative and quantitative difference among substance.
authors.affiliation: Department of Clinical Science and Translational Medicine, "Tor Vergata" University of Rome, Rome, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Fioravanti
authors.affiliation: Department of Clinical Science and Translational Medicine, "Tor Vergata" University of Rome, Rome, Italy.
authors.forename: I
authors.initials: I
authors.lastname: Frustaci
authors.affiliation: Department of Clinical Science and Translational Medicine, "Tor Vergata" University of Rome, Rome, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Armellin
authors.affiliation: Department of Clinical Science and Translational Medicine, "Tor Vergata" University of Rome, Rome, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Condò
authors.affiliation: Department of Clinical Science and Translational Medicine, "Tor Vergata" University of Rome, Rome, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Arcuri
authors.affiliation: Department of Clinical Science and Translational Medicine, "Tor Vergata" University of Rome, Rome, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Cerroni
keywords: bone regeneration; platelet growth factors; platelet rich fibrin; platelet rich plasma