title: 1D-spectral editing and 2D multispectral in vivo1H-MRS and1H-MRSI - Methods and applications.
abstract: This article reviews the methodological aspects of detecting low-abundant J-coupled metabolites via 1D spectral editing techniques and 2D nuclear magnetic resonance (NMR) methods applied in vivo, in humans, with a focus on the brain. A brief explanation of the basics of J-evolution will be followed by an introduction to 1D spectral editing techniques (e.g., J-difference editing, multiple quantum coherence filtering) and 2D-NMR methods (e.g., correlation spectroscopy, J-resolved spectroscopy). Established and recently developed methods will be discussed and the most commonly edited J-coupled metabolites (e.g., neurotransmitters, antioxidants, onco-markers, and markers for metabolic processes) will be briefly summarized along with their most important applications in neuroscience and clinical diagnosis.
authors.affiliation: High-Field MR Center, Department of Biomedical Imaging and Image-guided Therapy, Medical University Vienna, Vienna, Austria. Electronic address: wolfgang.bogner@meduniwien.ac.at.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Bogner
authors.affiliation: High-Field MR Center, Department of Biomedical Imaging and Image-guided Therapy, Medical University Vienna, Vienna, Austria. Electronic address: gilbert.hangel@meduniwien.ac.at.
authors.forename: Gilbert
authors.initials: G
authors.lastname: Hangel
authors.affiliation: Department of Circulation and Medical Imaging, NTNU, Norwegian University of Science and Technology, Trondheim, Norway; Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Electronic address: m.esmaeili@ntnu.no.
authors.forename: Morteza
authors.initials: M
authors.lastname: Esmaeili
authors.affiliation: Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Electronic address: ovidiu@nmr.mgh.harvard.edu.
authors.forename: Ovidiu C
authors.initials: OC
authors.lastname: Andronesi
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*
chemical_list: D015415:Biomarkers
keywords: 2D NMR spectroscopy; Correlation spectroscopy; J-difference editing; J-resolved NMR spectroscopy; Multiple quantum coherence filtering; Spectral editing