title: Biotransformation of 20(R)-panaxatriol by Mucor racemosus and the anti-hepatic fibrosis activity of some products.
abstract: Biocatalysis of 20(R)-panaxatriol (PT) was performed by the fungus Mucor racemosus. Six metabolites (1-6) including five new compounds were obtained, and their structures were elucidated as 20(R),25-epoxy-12β,24β-dihydroxydammaran-3,6-dione (2), 20(R),25-epoxy-12β,22β-dihydroxydammaran-3,6-dione (3), 20(R),25-epoxy-23β-hydroxydammaran-3,6,12-trione (4), 20(R),25-epoxy-12β,23α- dihydroxydammaran-3,6-dione (5), and 20(R),25-epoxy-12β-hydroxydammaran-3,6,23-trione (6) by spectroscopic analysis. Pharmacological studies revealed that compounds 2, 3 and 5 exhibited significant antihepatic fibrosis activity, while 4 and 6 showed cytotoxicity against HSC-T6 cells.
authors.affiliation: a School of Pharmacy , Nantong University , Nantong , P.R. China.
authors.forename: Guangtong
authors.initials: G
authors.lastname: Chen
authors.affiliation: a School of Pharmacy , Nantong University , Nantong , P.R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.affiliation: a School of Pharmacy , Nantong University , Nantong , P.R. China.
authors.forename: Sensen
authors.initials: S
authors.lastname: Yan
authors.affiliation: a School of Pharmacy , Nantong University , Nantong , P.R. China.
authors.forename: Haijun
authors.initials: H
authors.lastname: Lin
authors.affiliation: b School of Medical , Nantong University , Nantong , P.R. China.
authors.forename: Juanjuan
authors.initials: J
authors.lastname: Wu
authors.affiliation: b School of Medical , Nantong University , Nantong , P.R. China.
authors.forename: Xuguang
authors.initials: X
authors.lastname: Zhai
authors.affiliation: a School of Pharmacy , Nantong University , Nantong , P.R. China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Song
authors.affiliation: a School of Pharmacy , Nantong University , Nantong , P.R. China.
authors.forename: Jianlin
authors.initials: J
authors.lastname: Li
mesh_terms: D001711:Biotransformation; D002460:Cell Line; D004353:Drug Evaluation, Preclinical / Q000379:methods; D036145:Ginsenosides / Q000493:pharmacokinetics*; D055166:Hepatic Stellate Cells / Q000187:drug effects / Q000473:pathology; D006801:Humans; D008103:Liver Cirrhosis / Q000188:drug therapy*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009089:Mucor / Q000378:metabolism*; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology*
chemical_list: C000625987:20(R),25-epoxy-12beta,23alpha- dihydroxydammaran-3,6-dione; D036145:Ginsenosides; D014315:Triterpenes; C004563:panaxatriol
keywords: 20(R)-panaxatriol; Biotransformation; Mucor racemosus; antihepatic fibrosis