title: Event-related potentials (ERP) and SGIP1 gene polymorphisms in alcoholics: relation to family history of alcoholism and drug usage.
abstract: The electrophysiological characteristics may serve as valuable biomarkers for the genetic vulnerability underlying alcoholism. The purpose of this study was to evaluate the potential associations between single nucleotide polymorphisms (SNPs) located in the SGIP1 gene and the theta ERP quantitative traits.
  
  
  
  The theta band (4-7 Hz) visual ERP occurring in the P300 response in the resting EEG were examined to explore the electrophysiological effects of alcohol on the brain in five regions: frontal, central, parietal, temporal and occipital in patients with alcohol addiction. In addition, we tested the potential associations between single nucleotide polymorphisms (SNPs) located in the SGIP1 gene and ERP quantitative traits.
  
  
  
  We found that the amplitude of the auditory P300 response differed considerably among groups of alcoholics in the frontal, central and temporal areas of the brain and it was lower in the studied brain regions in alcoholics in comparison to non-alcoholics. However, among subjects in the young adult group (GR-1) there was no statistical difference in amplitude of P300 response with control subjects in all studied brain regions in comparison with non-alcoholics. Moreover, we revealed that SNP rs10889635 had a significant effect on P300 amplitude in the central and temporal regions. The reduced P300 amplitude was in AA carriers in comparison to both carriers of GG and GA alleles.
  
  
  
  The present study demonstrated a possible association of target P300 evoked theta and of alcohol dependence with SNPs from the gene SGIP1 in the region of rs10889635, but further studies are required.
authors.affiliation: Department of Neurodegenerative Diseas, Institute of Rural Health, Lublin, Poland.
authors.forename: Roman
authors.initials: R
authors.lastname: Chwedorowicz
authors.affiliation: Department of Physiopathology, Institute of Rural Health, Lublin, Poland.
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Raszewski
authors.affiliation: Department of Molecular Biology and Translational Research, Institute of Rural Health, Lublin, Poland.
authors.forename: Lucyna
authors.initials: L
authors.lastname: Kapka-Skrzypczak
authors.affiliation: Department of Molecular Biology and Translational Research, Institute of Rural Health, Lublin, Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Sawicki
authors.affiliation: Department of Neurodegenerative Diseases, Institute of Rural Health, Lublin, Poland.
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Studziński
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000293:Adolescent; D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000235:genetics*; D015415:Biomarkers; D001921:Brain / Q000502:physiology*; D002352:Carrier Proteins / Q000235:genetics* / Q000378:metabolism; D004569:Electroencephalography; D005071:Evoked Potentials; D005260:Female; D015870:Gene Expression; D006801:Humans; D008297:Male; D008565:Membrane Proteins; D008875:Middle Aged; D011044:Poland; D020641:Polymorphism, Single Nucleotide; D019966:Substance-Related Disorders / Q000235:genetics; D055815:Young Adult
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D015415:Biomarkers; D002352:Carrier Proteins; D008565:Membrane Proteins; C523897:SGIP1 protein, human