title: Correlation of PET/CT and Image-Guided Biopsies of Pediatric Malignancies.
abstract: OBJECTIVE
  The purpose of this study was to evaluate an early experience with correlation of PET/CT findings and image-guided biopsy results in pediatric patients.
  
  
  METHODS
  In a single-center retrospective case series, the inclusion criterion was performance of image-guided biopsy within 6 weeks of PET/CT, either before or after the biopsy.
  
  
  RESULTS
  Forty-five patients (23 boys, 22 girls; age range, 4-17 years; median, 10.5 years; weight range, 14.6-86.2 kg; median, 48 kg) underwent 47 PET/CT examinations and biopsies. Nineteen patients (20 biopsies) had known malignancy, and 26 patients had suspected malignancy. The results were malignant in 24 cases, benign in 16, and inadequate or normal in 7 cases. Thirty-nine of 47 PET/CT examinations had positive results, and eight had negative results. Final analysis of 37 of the 47 cases (confounders excluded) showed concordant results between biopsy and PET in 36 cases and discordant results in one case.
  
  
  CONCLUSIONS
  PET/CT can be used for disease staging and follow-up. In the future PET/CT can play a valuable role in directing image-guided biopsies of children.
authors.affiliation: 1 Department of Radiology, Prince Sultan Military Medical City, PO Box 7897, Riyadh 11159, Kingdom of Saudi Arabia.|2 Division of Image Guided Therapy, Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, ON, Canada.
authors.forename: Saeed
authors.initials: S
authors.lastname: Nihayah
authors.affiliation: 3 Division of Nuclear Medicine, Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, ON, Canada.
authors.forename: Amer
authors.initials: A
authors.lastname: Shammas
authors.affiliation: 3 Division of Nuclear Medicine, Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, ON, Canada.
authors.forename: Reza
authors.initials: R
authors.lastname: Vali
authors.affiliation: 2 Division of Image Guided Therapy, Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, ON, Canada.
authors.forename: Dimitri
authors.initials: D
authors.lastname: Parra
authors.affiliation: 4 Department of Hematology and Oncology, The Hospital for Sick Children, Toronto, ON, Canada.
authors.forename: Sarah
authors.initials: S
authors.lastname: Alexander
authors.affiliation: 4 Department of Hematology and Oncology, The Hospital for Sick Children, Toronto, ON, Canada.
authors.forename: Joao
authors.initials: J
authors.lastname: Amaral
authors.affiliation: 2 Division of Image Guided Therapy, Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, ON, Canada.
authors.forename: Bairbre
authors.initials: B
authors.lastname: Connolly
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D061705:Image-Guided Biopsy / Q000379:methods*; D008297:Male; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D000072078:Positron Emission Tomography Computed Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013223:Statistics as Topic
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: PET/CT; children's malignancies; image-guided biopsy; malignancies