title: Delta Opioid Receptors: Learning and Motivation.
abstract: Delta opioid receptor (DOR) displays a unique, highly conserved, structure and an original pattern of distribution in the central nervous system, pointing to a distinct and specific functional role among opioid peptide receptors. Over the last 15 years, in vivo pharmacology and genetic models have allowed significant advances in the understanding of this role. In this review, we will focus on the involvement of DOR in modulating different types of hippocampal- and striatal-dependent learning processes as well as motor function, motivation, and reward. Remarkably, DOR seems to play a key role in balancing hippocampal and striatal functions, with major implications for the control of cognitive performance and motor function under healthy and pathological conditions.
authors.affiliation: Physiologie de la Reproduction et des Comportements, INRA UMR-0085, CNRS UMR-7247, INSERM, Université François Rabelais, IFCE, 37380, Nouzilly, France.
authors.forename: L P
authors.initials: LP
authors.lastname: Pellissier
authors.affiliation: Département de Neurosciences, Institut de Génomique fonctionnelle, INSERM U-661, CNRS UMR-5203, 34094, Montpellier, France.
authors.forename: C N
authors.initials: CN
authors.lastname: Pujol
authors.affiliation: Physiologie de la Reproduction et des Comportements, INRA UMR-0085, CNRS UMR-7247, INSERM, Université François Rabelais, IFCE, 37380, Nouzilly, France.
authors.forename: J A J
authors.initials: JAJ
authors.lastname: Becker
authors.affiliation: Physiologie de la Reproduction et des Comportements, INRA UMR-0085, CNRS UMR-7247, INSERM, Université François Rabelais, IFCE, 37380, Nouzilly, France. Julie.lemerrer@tours.inra.fr.
authors.forename: J
authors.initials: J
authors.lastname: Le Merrer
mesh_terms: D000818:Animals; D006801:Humans; D007858:Learning / Q000187:drug effects / Q000502:physiology*; D009042:Motivation / Q000187:drug effects / Q000502:physiology*; D017465:Receptors, Opioid, delta / Q000096:biosynthesis / Q000187:drug effects / Q000502:physiology*; D012201:Reward
chemical_list: D017465:Receptors, Opioid, delta
keywords: Associative learning; Drug–context associations; GPR88; Hippocampus; Procedural learning; Striatum