title: Hydrogen donors and acceptors and basic amino acids jointly contribute to carcinogenesis.
abstract: A hypothesis is postulated that high content of hydrogen donors and acceptors, and basic amino acids cause the intracellular trapping of the H+and Cl-ions, which increases cancer risks as local formation of HCl is mutagenic to DNA. Other cations such as Ca2+, and weak acids such as short-chain organic acids may attenuate the intracellular gathering of the H+and Cl-, two of the most abundant ions in the cells. Current data on increased cancer risks in diabetic and obese patients are consistent with the assumption that hydrogen bonding propensity on glucose, triglycerides and other molecules is among the causative factors.
authors.affiliation: State Key Laboratory of Biocontrol, MOE Key Laboratory of Aquatic Product Safety, The Key Laboratory of Gene Engineering of Ministry of Education, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
authors.forename: Man
authors.initials: M
authors.lastname: Tang
authors.affiliation: State Key Laboratory of Biocontrol, MOE Key Laboratory of Aquatic Product Safety, The Key Laboratory of Gene Engineering of Ministry of Education, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
authors.forename: Yanchao
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: State Key Laboratory of Biocontrol, MOE Key Laboratory of Aquatic Product Safety, The Key Laboratory of Gene Engineering of Ministry of Education, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
authors.forename: Yiqi
authors.initials: Y
authors.lastname: Li
authors.affiliation: State Key Laboratory of Biocontrol, MOE Key Laboratory of Aquatic Product Safety, The Key Laboratory of Gene Engineering of Ministry of Education, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
authors.forename: Juntong
authors.initials: J
authors.lastname: Zou
authors.affiliation: State Key Laboratory of Biocontrol, MOE Key Laboratory of Aquatic Product Safety, The Key Laboratory of Gene Engineering of Ministry of Education, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
authors.forename: Beicheng
authors.initials: B
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Biocontrol, MOE Key Laboratory of Aquatic Product Safety, The Key Laboratory of Gene Engineering of Ministry of Education, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
authors.forename: Li
authors.initials: L
authors.lastname: Cai
authors.affiliation: College of Life Sciences, Jilin University, Changchun 130012, China.
authors.forename: Xuelan
authors.initials: X
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Biocontrol, MOE Key Laboratory of Aquatic Product Safety, The Key Laboratory of Gene Engineering of Ministry of Education, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China. Electronic address: lsslqy@mail.sysu.edu.cn.
authors.forename: Qiuyun
authors.initials: Q
authors.lastname: Liu
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D024361:Amino Acids, Basic; D000818:Animals; D000838:Anions; D002118:Calcium / Q000737:chemistry; D063646:Carcinogenesis / Q000378:metabolism*; D002482:Cellulose / Q000737:chemistry; D002713:Chlorine / Q000737:chemistry; D004247:DNA / Q000032:analysis; D005947:Glucose / Q000737:chemistry; D006801:Humans; D006851:Hydrochloric Acid / Q000737:chemistry; D006859:Hydrogen / Q000737:chemistry*; D006860:Hydrogen Bonding; D051379:Mice; D008819:Mice, Nude; D008822:Mice, Transgenic; D016296:Mutagenesis; D009211:Myoglobin / Q000378:metabolism; D010455:Peptides / Q000737:chemistry; D011522:Protons; D014280:Triglycerides / Q000737:chemistry
chemical_list: D000596:Amino Acids; D024361:Amino Acids, Basic; D000838:Anions; D009211:Myoglobin; D010455:Peptides; D011522:Protons; D014280:Triglycerides; D002713:Chlorine; D006859:Hydrogen; D002482:Cellulose; D004247:DNA; D005947:Glucose; D006851:Hydrochloric Acid; D002118:Calcium
keywords: Basic amino acids; Cancer risks; H(+) and Cl(−) ions; Hydrogen donors and acceptors