title: The Ontario Neurodegenerative Disease Research Initiative (ONDRI).
abstract: Because individuals develop dementia as a manifestation of neurodegenerative or neurovascular disorder, there is a need to develop reliable approaches to their identification. We are undertaking an observational study (Ontario Neurodegenerative Disease Research Initiative [ONDRI]) that includes genomics, neuroimaging, and assessments of cognition as well as language, speech, gait, retinal imaging, and eye tracking. Disorders studied include Alzheimer's disease, amyotrophic lateral sclerosis, frontotemporal dementia, Parkinson's disease, and vascular cognitive impairment. Data from ONDRI will be collected into the Brain-CODE database to facilitate correlative analysis. ONDRI will provide a repertoire of endophenotyped individuals that will be a unique, publicly available resource.
authors.affiliation: 1Department of Biochemistry,Schulich School of Medicine & Dentistry,Western University,London,Canada.
authors.forename: Sali M K
authors.initials: SM
authors.lastname: Farhan
authors.affiliation: 2Robarts Research Institute,Western University,London,Canada.
authors.forename: Robert
authors.initials: R
authors.lastname: Bartha
authors.affiliation: 4Department of Medicine (Neurology),Sunnybrook Health Sciences Centre,LC Campbell Cognitive Neurology Research Unit,Hurvitz Brain Science Research Program,Sunnybrook Research Institute,University of Toronto,Toronto,Canada.
authors.forename: Sandra E
authors.initials: SE
authors.lastname: Black
authors.affiliation: 6Department of Cellular and Molecular Medicine, Faculty of Medicine,University of Ottawa,Ottawa,Canada.
authors.forename: Dale
authors.initials: D
authors.lastname: Corbett
authors.affiliation: 7Department of Clinical Neurological Sciences,Schulich School of Medicine & Dentistry,Western University,London,Canada.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Finger
authors.affiliation: 8Department of Medicine (Neurology),Baycrest Health Sciences and University of Toronto,Toronto,Ontario,Canada.
authors.forename: Morris
authors.initials: M
authors.lastname: Freedman
authors.affiliation: 10Toronto Dementia Research Alliance,University Health Network,Toronto,Canada.
authors.forename: Barry
authors.initials: B
authors.lastname: Greenberg
authors.affiliation: 11Department of Medicine,The Ottawa Hospital, Faculty of Medicine,University of Ottawa,Ottawa,Canada.
authors.forename: David A
authors.initials: DA
authors.lastname: Grimes
authors.affiliation: 1Department of Biochemistry,Schulich School of Medicine & Dentistry,Western University,London,Canada.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Hegele
authors.affiliation: 12School of Optometry & Vision Science,University of Waterloo,Waterloo,Canada.
authors.forename: Chris
authors.initials: C
authors.lastname: Hudson
authors.affiliation: 13Schulich School of Medicine & Dentistry,Western University,London,Canada.
authors.forename: Peter W
authors.initials: PW
authors.lastname: Kleinstiver
authors.affiliation: 14Morton and Gloria Shulman Movement Disorders Clinic and the Edmond J Safra Program in Parkinson's Disease,Toronto Western Hospital and the Department of Medicine,University of Toronto,Toronto,Canada.
authors.forename: Anthony E
authors.initials: AE
authors.lastname: Lang
authors.affiliation: 4Department of Medicine (Neurology),Sunnybrook Health Sciences Centre,LC Campbell Cognitive Neurology Research Unit,Hurvitz Brain Science Research Program,Sunnybrook Research Institute,University of Toronto,Toronto,Canada.
authors.forename: Mario
authors.initials: M
authors.lastname: Masellis
authors.affiliation: 15Department of Kinesiology,University of Waterloo,Waterloo,Canada.
authors.forename: William E
authors.initials: WE
authors.lastname: McIlroy
authors.affiliation: 13Schulich School of Medicine & Dentistry,Western University,London,Canada.
authors.forename: Paula M
authors.initials: PM
authors.lastname: McLaughlin
authors.affiliation: 16Gait and Brain Lab,Department of Medicine (Geriatrics) and Epidemiology and Biostatistics,Schulich School of Medicine & Dentistry,London,Canada.
authors.forename: Manuel
authors.initials: M
authors.lastname: Montero-Odasso
authors.affiliation: 17Keenan Research Centre for Biomedical Science of St. Michael's Hospital,Laboratory Medicine and Pathobiology,University of Toronto,Division of Pathology,St. Michael's Hospital,Toronto,Canada.
authors.forename: David G
authors.initials: DG
authors.lastname: Munoz
authors.affiliation: 18Centre for Neuroscience Studies,Queen's University,Kingston,Canada.
authors.forename: Douglas P
authors.initials: DP
authors.lastname: Munoz
authors.affiliation: 19Rotman Research Institute,Baycrest,Department of Medical Biophysics,University of Toronto,Toronto,Canada.
authors.forename: Stephen
authors.initials: S
authors.lastname: Strother
authors.affiliation: 20Department of Medicine (Neurology),L.C. Campbell Cognitive Neurology Research Unit,Hurvitz Brain Science Research Program,Sunnybrook Research Institute,Sunnybrook Health Sciences Centre,Institute of Medical Science, Faculty of Medicine,University of Toronto,Toronto,Canada.
authors.forename: Richard H
authors.identifier: http://orcid.org/0000-0003-2542-3512
authors.initials: RH
authors.lastname: Swartz
authors.affiliation: 21Department of Medical Imaging,Sunnybrook Health Sciences Centre,Toronto,Canada.
authors.forename: Sean
authors.initials: S
authors.lastname: Symons
authors.affiliation: 22Division of Neurology and Department of Medicine,University of Toronto. Tanz Centre for Research in Neurodegenerative Diseases,University of Toronto,Toronto,Canada.
authors.forename: Maria Carmela
authors.initials: MC
authors.lastname: Tartaglia
authors.affiliation: 4Department of Medicine (Neurology),Sunnybrook Health Sciences Centre,LC Campbell Cognitive Neurology Research Unit,Hurvitz Brain Science Research Program,Sunnybrook Research Institute,University of Toronto,Toronto,Canada.
authors.forename: Lorne
authors.initials: L
authors.lastname: Zinman
authors.affiliation: 2Robarts Research Institute,Western University,London,Canada.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Strong
mesh_terms: D006801:Humans; D008137:Longitudinal Studies; D019636:Neurodegenerative Diseases / Q000175:diagnosis*; D009864:Ontario
keywords: Alzheimer’s; Amyotrophic Lateral Sclerosis; Dementia; Frontotemporal Dementia; Neurodegeneration; Parkinson Disease; vascular cognitive impairment