title: A 12-week intervention with nonivamide, a TRPV1 agonist, prevents a dietary-induced body fat gain and increases peripheral serotonin in moderately overweight subjects.
abstract: A bolus administration of 0.15 mg nonivamide has previously been demonstrated to reduce energy intake in moderately overweight men. This 12-week intervention investigated whether a daily consumption of nonivamide in a protein-based product formulation promotes a reduction in body weight in healthy overweight subjects and affects outcome measures associated with mechanisms regulating food intake, e.g. plasma concentrations of (an)orexigenic hormones, energy substrates as well as changes in fecal microbiota.
  
  
  
  Nineteen overweight subjects were randomly assigned to either a control (C) or a nonivamide (NV) group. Changes in the body composition and plasma concentrations of satiating hormones were determined at fasting and 15, 30, 60, 90, and 120 min after a glucose load. Participants were instructed to consume 0.15 mg nonivamide per day in 450 mL of a milk shake additionally to their habitual diet. After treatment, a group difference in body fat mass change (-0.61 ± 0.36% in NV and +1.36 ± 0.38% in C) and an increase in postprandial plasma serotonin were demonstrated. Plasma metabolome and fecal microbiome read outs were not affected.
  
  
  
  A daily intake of 0.15 mg nonivamide helps to support to maintain a healthy body composition.
authors.affiliation: Christian Doppler Laboratory for Bioactive Aroma Compounds, University of Vienna, Vienna, Austria.
authors.forename: Christina M
authors.initials: CM
authors.lastname: Hochkogler
authors.affiliation: Christian Doppler Laboratory for Bioactive Aroma Compounds, University of Vienna, Vienna, Austria.|Department of Nutritional and Physiological Chemistry, Faculty of Chemistry, University of Vienna, Vienna, Austria.
authors.forename: Barbara
authors.initials: B
authors.lastname: Lieder
authors.affiliation: Department of Nutritional Sciences, Faculty of Life Sciences, University of Vienna, Vienna, Austria.
authors.forename: Petra
authors.initials: P
authors.lastname: Rust
authors.affiliation: Division of Microbial Ecology, Department of Microbiology and Ecosystem Science, Faculty of Life Sciences, University of Vienna, Vienna, Austria.
authors.forename: David
authors.initials: D
authors.lastname: Berry
authors.affiliation: Department of Analytical Chemistry, Faculty of Chemistry, University of Vienna, Austria.
authors.forename: Samuel M
authors.initials: SM
authors.lastname: Meier
authors.affiliation: Department of Nutritional and Physiological Chemistry, Faculty of Chemistry, University of Vienna, Vienna, Austria.
authors.forename: Marc
authors.initials: M
authors.lastname: Pignitter
authors.affiliation: Division of Microbial Ecology, Department of Microbiology and Ecosystem Science, Faculty of Life Sciences, University of Vienna, Vienna, Austria.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Riva
authors.affiliation: Christian Doppler Laboratory for Bioactive Aroma Compounds, University of Vienna, Vienna, Austria.
authors.forename: Alina
authors.initials: A
authors.lastname: Leitinger
authors.affiliation: Christian Doppler Laboratory for Bioactive Aroma Compounds, University of Vienna, Vienna, Austria.
authors.forename: Anne
authors.initials: A
authors.lastname: Bruk
authors.affiliation: Department of Nutritional Sciences, Faculty of Life Sciences, University of Vienna, Vienna, Austria.
authors.forename: Simone
authors.initials: S
authors.lastname: Wagner
authors.affiliation: Symrise AG, Holzminden, Germany.
authors.forename: Joachim
authors.initials: J
authors.lastname: Hans
authors.affiliation: Symrise AG, Holzminden, Germany.
authors.forename: Sabine
authors.initials: S
authors.lastname: Widder
authors.affiliation: Symrise AG, Holzminden, Germany.
authors.forename: Jakob P
authors.initials: JP
authors.lastname: Ley
authors.affiliation: Symrise AG, Holzminden, Germany.
authors.forename: Gerhard E
authors.initials: GE
authors.lastname: Krammer
authors.affiliation: Christian Doppler Laboratory for Bioactive Aroma Compounds, University of Vienna, Vienna, Austria.|Department of Nutritional and Physiological Chemistry, Faculty of Chemistry, University of Vienna, Vienna, Austria.
authors.forename: Veronika
authors.initials: V
authors.lastname: Somoza
mesh_terms: D052242:Adiponectin / Q000097:blood; D050154:Adiposity / Q000187:drug effects; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D001823:Body Composition; D015992:Body Mass Index; D001835:Body Weight; D002211:Capsaicin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D002784:Cholesterol / Q000097:blood; D004032:Diet; D004041:Dietary Fats / Q000009:adverse effects*; D005260:Female; D005768:Gastrointestinal Hormones / Q000097:blood; D000069196:Gastrointestinal Microbiome / Q000187:drug effects; D006801:Humans; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood; D008297:Male; D050177:Overweight / Q000188:drug therapy*; D019518:Postprandial Period; D012527:Satiation; D018689:Sensory System Agents / Q000008:administration & dosage; D012701:Serotonin / Q000097:blood*; D050916:TRPV Cation Channels / Q000819:agonists*; D014280:Triglycerides / Q000097:blood; D015430:Weight Gain / Q000187:drug effects*; D055815:Young Adult
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D004041:Dietary Fats; D005768:Gastrointestinal Hormones; D007328:Insulin; D020738:Leptin; D018689:Sensory System Agents; D050916:TRPV Cation Channels; C494482:TRPV1 protein, human; D014280:Triglycerides; D012701:Serotonin; D002784:Cholesterol; D002211:Capsaicin; C040937:nonivamide
keywords: Body composition; Capsaicin; Nonivamide; Peripheral serotonin; Satiety