title: Design and Synthesis of Tris-Heteroleptic Cyclometalated Iridium(III) Complexes Consisting of Three Different Nonsymmetric Ligands Based on Ligand-Selective Electrophilic Reactions via Interligand HOMO Hopping Phenomena.
abstract: In this article we report on the successful synthesis and isolation of cyclometalated Ir complexes having three different nonsymmetric ligands based on ligand-selective electrophilic reactions via interligand HOMO (highest occupied molecular orbital) hopping phenomena. It was hypothesized that the electrophilic substitution reactions of bis-heteroleptic Ir complexes having 8-benzenesulfonamidoquinoline as an ancillary ligand, 5a and 7, would proceed at the 5 position of the quinoline ring of these Ir complexes to afford 18 and 19, because their HOMOs are localized on the quinoline rings, as predicted by density functional theory (DFT) calculations. In these products, the HOMO is transferred to one of two ppy ligands, in which the phenyl group is trans to the Ir-N (1 position of quinoline) bond, and hence, the iodination or formylation of 18 and 19 occurs at the 5' position of the ppy ligand to provide 20a, 23, and 24. Furthermore, we carried out the functionalization of 20a using cross-coupling reactions to obtain tris-heteroleptic Ir complexes containing three different ligands in good yields with negligible diastereomer formation. Photochemical properties, especially dual emission, and response to pH change, of new dual-emissive tris-heteroleptic cyclometalated Ir complexes, 21-24, are also reported.
authors.affiliation: Faculty of Pharmaceutical Sciences, ‡Division of Medical Science-Engineering Cooperation, Research Institute for Science and Technology, and §Imaging Frontier Center, Research Institute for Science and Technology, Tokyo University of Science , 2641 Yamazaki, Noda, Chiba 278-8510, Japan.
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Hisamatsu
authors.affiliation: Faculty of Pharmaceutical Sciences, ‡Division of Medical Science-Engineering Cooperation, Research Institute for Science and Technology, and §Imaging Frontier Center, Research Institute for Science and Technology, Tokyo University of Science , 2641 Yamazaki, Noda, Chiba 278-8510, Japan.
authors.forename: Sarvendra
authors.initials: S
authors.lastname: Kumar
authors.affiliation: Faculty of Pharmaceutical Sciences, ‡Division of Medical Science-Engineering Cooperation, Research Institute for Science and Technology, and §Imaging Frontier Center, Research Institute for Science and Technology, Tokyo University of Science , 2641 Yamazaki, Noda, Chiba 278-8510, Japan.
authors.forename: Shin
authors.identifier: http://orcid.org/0000-0002-4287-6487
authors.initials: S
authors.lastname: Aoki