title: The promiscuous ectonucleotidase NPP1: molecular insights into substrate binding and hydrolysis.
authors.affiliation: PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical Sciences Bonn (PSB), Pharmaceutical Chemistry I, University of Bonn, Germany.
authors.forename: Vigneshwaran
authors.initials: V
authors.lastname: Namasivayam
authors.affiliation: PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical Sciences Bonn (PSB), Pharmaceutical Chemistry I, University of Bonn, Germany.
authors.forename: Sang-Yong
authors.initials: SY
authors.lastname: Lee
authors.affiliation: PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical Sciences Bonn (PSB), Pharmaceutical Chemistry I, University of Bonn, Germany. Electronic address: christa.mueller@uni-bonn.de.
authors.forename: Christa E
authors.initials: CE
authors.lastname: Müller
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000596:Amino Acids / Q000378:metabolism; D001665:Binding Sites / Q000502:physiology; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D015226:Dinucleoside Phosphates / Q000378:metabolism; D006801:Humans; D006868:Hydrolysis; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism*; D011485:Protein Binding / Q000502:physiology; D011755:Pyrophosphatases / Q000378:metabolism*; D013379:Substrate Specificity; D013938:Thymidine Monophosphate / Q000378:metabolism; D014544:Uridine Triphosphate / Q000378:metabolism
chemical_list: D000596:Amino Acids; D015226:Dinucleoside Phosphates; D013938:Thymidine Monophosphate; C020733:diadenosine tetraphosphate; D000255:Adenosine Triphosphate; D000242:Cyclic AMP; D010727:Phosphoric Diester Hydrolases; C065962:ectonucleotide pyrophosphatase phosphodiesterase 1; D011755:Pyrophosphatases; D006152:Cyclic GMP; D014544:Uridine Triphosphate
keywords: 2′,3″-cGAMP; Cancer immunotherapy; Nucleotide pyrophosphatase 1; Substrate promiscuity; cAMP