title: Quinolines: Microwave-assisted synthesis and their antifungal, anticancer and radical scavenger properties.
abstract: An efficient method for the synthesis of quinolines using microwave irradiation was developed providing 28 quinolines with good yields. The reaction procedures are environmentally friendly, convenient, mild and of easy work-up. Quinolines were evaluated for their antifungal, anticancer and antioxidant properties and exhibited high activities in all tests performed.
authors.affiliation: Grupo de Química Supramolecular e Biomimética (GQSB), Departamento de Química, Universidade Federal de Viçosa, Viçosa, MG 36570-900, Brazil.
authors.forename: Natália Aparecida
authors.initials: NA
authors.lastname: Liberto
authors.affiliation: Grupo de Química Supramolecular e Biomimética (GQSB), Departamento de Química, Universidade Federal de Viçosa, Viçosa, MG 36570-900, Brazil.
authors.forename: Juliana Baptista
authors.initials: JB
authors.lastname: Simões
authors.affiliation: Grupo de Química Supramolecular e Biomimética (GQSB), Departamento de Química, Universidade Federal de Viçosa, Viçosa, MG 36570-900, Brazil.
authors.forename: Sarah
authors.initials: S
authors.lastname: de Paiva Silva
authors.affiliation: Grupo de Estudos em Bioquímica de Plantas (GEBioPlan), Departamento de Botânica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG 31270-901, Brazil.
authors.forename: Cristiane Jovelina
authors.initials: CJ
authors.lastname: da Silva
authors.affiliation: Grupo de Estudos em Bioquímica de Plantas (GEBioPlan), Departamento de Botânica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG 31270-901, Brazil.
authors.forename: Luzia Valentina
authors.initials: LV
authors.lastname: Modolo
authors.affiliation: Grupo de Estudos em Química Orgânica e Biológica (GEQOB), Departamento de Química, ICEx, Universidade Federal de Minas Gerais, Belo Horizonte, MG 31270-901, Brazil.
authors.forename: Ângelo
authors.initials: Â
authors.lastname: de Fátima
authors.affiliation: Laboratório de Biologia Celular, Fundação Ezequiel Dias, Belo Horizonte, MG, Brazil.
authors.forename: Luciana Maria
authors.initials: LM
authors.lastname: Silva
authors.affiliation: Farmacognosia, Facultad de Ciencias Bioquimicas y Farmacuticas, Universidad Nacional de Rosario, Argentina.
authors.forename: Marcos
authors.initials: M
authors.lastname: Derita
authors.affiliation: Farmacognosia, Facultad de Ciencias Bioquimicas y Farmacuticas, Universidad Nacional de Rosario, Argentina.
authors.forename: Susana
authors.initials: S
authors.lastname: Zacchino
authors.affiliation: Centro de Investigación y Desarrollo en Ciencias Aplicadas 'Dr. Jorge J. Ronco' (CINDECA-CONICET-CCT-La Plata), Universidad Nacional de La Plata, Calle 47 No. 257, B1900AJK La Plata, Argentina.
authors.forename: Omar Miguel Portilla
authors.initials: OMP
authors.lastname: Zuñiga
authors.affiliation: Centro de Investigación y Desarrollo en Ciencias Aplicadas 'Dr. Jorge J. Ronco' (CINDECA-CONICET-CCT-La Plata), Universidad Nacional de La Plata, Calle 47 No. 257, B1900AJK La Plata, Argentina.
authors.forename: Gustavo Pablo
authors.initials: GP
authors.lastname: Romanelli
authors.affiliation: Grupo de Química Supramolecular e Biomimética (GQSB), Departamento de Química, Universidade Federal de Viçosa, Viçosa, MG 36570-900, Brazil. Electronic address: santonio@ufv.br.
authors.forename: Sergio Antonio
authors.initials: SA
authors.lastname: Fernandes
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D003455:Cryptococcus neoformans / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D008872:Microwaves; D015394:Molecular Structure; D011804:Quinolines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000935:Antifungal Agents; D016166:Free Radical Scavengers; D011804:Quinolines
keywords: Anticancer; Antifungal; Antioxidant; Calix[n]arenes; Quinoline