title: Improvement of Intestinal Immune Cell Function by Lactic Acid Bacteria for Dairy Products.
abstract: Lactic acid bacteria (LAB) form a major component of gut microbiota and are often used as probiotics for fermented foods, such as yoghurt. In this study, we aimed to evaluate immunomodulatory activity of LAB, especially that ofLactobacillus bulgaricusME-552 (ME552) andStreptococcus thermophilusME-553 (ME553). In vivo/in vitro assay was performed in order to investigate their effects on T cell function. After oral administration of ME553 to C57BL/6 mice, the amount of both interferon γ (IFN-γ) and interleukin 17 (IL-17) produced by cluster of differentiation (CD) 4⁺ T cells from Peyer's patches (PPs) were significantly enhanced. On the other hand, ME552 only up-regulated the production of IL-17 from PP cells. The extent of induction for IFN-γ production differed between ME552 and ME553. These results suggest that LAB modulate T cell effector functions and mucosal immunity.
authors.affiliation: Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki 305-8566, Japan. t-kamiya@aist.go.jp.
authors.forename: Tomonori
authors.initials: T
authors.lastname: Kamiya
authors.affiliation: Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki 305-8566, Japan. yohei-watanabe@aist.go.jp.
authors.forename: Yohei
authors.initials: Y
authors.lastname: Watanabe
authors.affiliation: Food Science Research Laboratories, Meiji Corporation, 540 Naruda, Odawara, Kanagawa 250-0862, Japan. seiya.makino@meiji.com.
authors.forename: Seiya
authors.initials: S
authors.lastname: Makino
authors.affiliation: Food Science Research Laboratories, Meiji Corporation, 540 Naruda, Odawara, Kanagawa 250-0862, Japan. hiroshi.kano@meiji.com.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kano
authors.affiliation: Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki 305-8566, Japan. nmtsuji@aist.go.jp.
authors.forename: Noriko M
authors.initials: NM
authors.lastname: Tsuji
keywords: Dendritic cells; Interferon γ; Interleukin 17; Lactic acid bacteria; Lactobacillus bulgaricus; Mucosal immunity; Peyer’s patches; Probiotics; Streptococcus thermophilus; T helper cells