title: Clinical and biochemical factors associated with preeclampsia in women with obesity.
abstract: To compare early pregnancy clinical and biomarker risk factors for later development of preeclampsia between women with obesity (body mass index, BMI ≥30 kg/m2) and those with a normal BMI (20-25 kg/m2).
  
  
  
  In 3,940 eligible nulliparous women from the Screening for Pregnancy Endpoints (SCOPE) study, a total of 53 biomarkers of glucose and lipid metabolism, placental function, and known markers of preeclampsia were measured at 14 to 16 weeks' gestation. Logistic regression was performed to identify clinical and biomarker risk factors for preeclampsia in women with and without obesity.
  
  
  
  Among 834 women with obesity and 3,106 with a normal BMI, 77 (9.2%) and 105 (3.4%) developed preeclampsia, respectively. In women with obesity, risk factors included a family history of thrombotic disease, low plasma placental growth factor, and higher uterine artery resistance index at 20 weeks. In women with a normal BMI, a family history of preeclampsia or gestational hypertension, mean arterial blood pressure, plasma endoglin and cystatin C, and uterine artery resistance index were associated with preeclampsia, while high fruit intake was protective.
  
  
  
  Women with obesity and a normal BMI have different early pregnancy clinical and biomarker risk factors for preeclampsia.
authors.affiliation: Division of Women's Health, Women's Health Academic Centre, King's College London and King's Health Partners, London, UK.
authors.forename: Matias C
authors.identifier: 0000-0002-8076-4275
authors.initials: MC
authors.lastname: Vieira
authors.affiliation: Division of Women's Health, Women's Health Academic Centre, King's College London and King's Health Partners, London, UK.
authors.forename: Lucilla
authors.initials: L
authors.lastname: Poston
authors.affiliation: Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
authors.forename: Elaine
authors.initials: E
authors.lastname: Fyfe
authors.affiliation: Division of Women's Health, Women's Health Academic Centre, King's College London and King's Health Partners, London, UK.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Gillett
authors.affiliation: The Irish Centre for Fetal and Neonatal Translational Research (INFANT), Department of Obstetrics and Gynaecology, University College Cork, Cork University Maternity Hospital, Wilton, Cork, Ireland.
authors.forename: Louise C
authors.initials: LC
authors.lastname: Kenny
authors.affiliation: Discipline of Obstetrics and Gynaecology, Robinson Research Institute, University of Adelaide, Adelaide, South Australia.
authors.forename: Claire T
authors.initials: CT
authors.lastname: Roberts
authors.affiliation: College of Medicine, Biological Sciences & Psychology, University of Leicester, UK.
authors.forename: Philip N
authors.initials: PN
authors.lastname: Baker
authors.affiliation: Division of Developmental Biology, School of Medical Sciences, The Faculty of Biology Medicine and Health, Manchester Academic Heath Science Centre, University of Manchester, UK.
authors.forename: Jenny E
authors.initials: JE
authors.lastname: Myers
authors.affiliation: Department of Obstetrics and Gynaecology, Leeds Institute of Biomedical & Clinical Sciences, University of Leeds, UK.
authors.forename: James J
authors.initials: JJ
authors.lastname: Walker
authors.affiliation: Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
authors.forename: Lesley M
authors.initials: LM
authors.lastname: McCowan
authors.affiliation: Division of Women's Health, Women's Health Academic Centre, King's College London and King's Health Partners, London, UK.
authors.forename: Robyn A
authors.initials: RA
authors.lastname: North
authors.affiliation: Division of Women's Health, Women's Health Academic Centre, King's College London and King's Health Partners, London, UK.
authors.forename: Dharmintra
authors.initials: D
authors.lastname: Pasupathy
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D005260:Female; D005865:Gestational Age; D006801:Humans; D009765:Obesity / Q000097:blood* / Q000150:complications* / Q000503:physiopathology; D010298:Parity; D000072483:Placenta Growth Factor / Q000097:blood; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D011257:Pregnancy Proteins; D012307:Risk Factors; D055988:Uterine Artery / Q000503:physiopathology; D014655:Vascular Resistance / Q000502:physiology
chemical_list: D015415:Biomarkers; D011257:Pregnancy Proteins; D000072483:Placenta Growth Factor