title: Perceptually relevant remapping of human somatotopy in 24 hours.
abstract: Experience-dependent reorganisation of functional maps in the cerebral cortex is well described in the primary sensory cortices. However, there is relatively little evidence for such cortical reorganisation over the short-term. Using human somatosensory cortex as a model, we investigated the effects of a 24 hr gluing manipulation in which the right index and right middle fingers (digits 2 and 3) were adjoined with surgical glue. Somatotopic representations, assessed with two 7 tesla fMRI protocols, revealed rapid off-target reorganisation in the non-manipulated fingers following gluing, with the representation of the ring finger (digit 4) shifted towards the little finger (digit 5) and away from the middle finger (digit 3). These shifts were also evident in two behavioural tasks conducted in an independent cohort, showing reduced sensitivity for discriminating the temporal order of stimuli to the ring and little fingers, and increased substitution errors across this pair on a speeded reaction time task.
authors.affiliation: Oxford Centre for fMRI of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.|University College, Oxford, United Kingdom.
authors.forename: James
authors.identifier: 0000-0002-1599-6440
authors.initials: J
authors.lastname: Kolasinski
authors.affiliation: Oxford Centre for fMRI of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.|Institute of Cognitive Neuroscience, University College London, London, United Kingdom.
authors.forename: Tamar R
authors.identifier: 0000-0002-5816-8979
authors.initials: TR
authors.lastname: Makin
authors.affiliation: Oxford Centre for fMRI of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.
authors.forename: John P
authors.identifier: 0000-0002-4469-2948
authors.initials: JP
authors.lastname: Logan
authors.affiliation: Oxford Centre for fMRI of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.
authors.forename: Saad
authors.initials: S
authors.lastname: Jbabdi
authors.affiliation: Oxford Centre for fMRI of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.
authors.forename: Stuart
authors.initials: S
authors.lastname: Clare
authors.affiliation: Oxford Centre for fMRI of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.|Oxford Centre for Human Brain Activity, Department of Psychiatry, University of Oxford, Oxford, United Kingdom.
authors.forename: Charlotte J
authors.initials: CJ
authors.lastname: Stagg
authors.affiliation: Oxford Centre for fMRI of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.
authors.forename: Heidi
authors.initials: H
authors.lastname: Johansen-Berg
mesh_terms: D000328:Adult; D001931:Brain Mapping / Q000379:methods*; D005073:Evoked Potentials, Somatosensory / Q000502:physiology*; D005260:Female; D005385:Fingers / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010812:Physical Stimulation; D011930:Reaction Time / Q000502:physiology; D013003:Somatosensory Cortex / Q000033:anatomy & histology / Q000502:physiology*; D055698:Touch Perception / Q000502:physiology*
keywords: human; neuroscience; plasticity; somatosensory; topography