title: Treatment of hidradenitis suppurativa with intralesional photodynamic therapy with 5-aminolevulinic acid and 630nm laser beam.
abstract: BACKGROUND
  Hidradenitis suppurativa (HS) is a chronic relapsing inflammatory skin disease with multiple treatment options that have been used with mixed results.
  
  
  OBJECTIVE
  To evaluate the effectiveness, safety and tolerability of intralesional photodynamic therapy (I-PDT) in the management of HS. Also, to assess the effect of this technique on the different areas treated.
  
  
  METHODS
  Case series of 38 HS patients treated with I-PDT between 2011-2015 following a standardized protocol to assess response at the treated areas RESULTS: 29 patients achieved a complete response, while persistence was noted on 8 cases and only 1 suffered a recurrence. Difference between basal (median 28.5) and final (0) Hidradenitis Severity Score showed a significant reduction of 24.5 points (p<0.001, 95% OR 19.5-31). Basal (median 10) and final (1) Dermatology Life Quality Index scores reached a reduction of 10 points (p<0.001, 95%OR 8-12). Complete response was achieved in 68.2% of armpits, 88.5% of groins, 88.9% of buttocks and 100% of other locations. 18 out of 38 patients needed only a session to achieve a complete response, while maintaining a good tolerability.
  
  
  CONCLUSIONS
  We believe that I-PDT might be an alternative treatment option for localized HS lesions, achieving a high rate of remission with an adequate maintenance of response i and few complications.
authors.affiliation: Department of Dermatology, Complejo Asistencial Universitario de León, Spain. Electronic address: majesv88@gmail.com.
authors.forename: María Jesús
authors.initials: MJ
authors.lastname: Suárez Valladares
authors.affiliation: Department of Dermatology, Complejo Asistencial Universitario de León, Spain.
authors.forename: Noemi
authors.initials: N
authors.lastname: Eiris Salvado
authors.affiliation: Department of Dermatology, Complejo Asistencial Universitario de León, Spain.
authors.forename: Manuel Angel
authors.initials: MA
authors.lastname: Rodríguez Prieto
mesh_terms: D000328:Adult; D000622:Aminolevulinic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D017497:Hidradenitis Suppurativa / Q000188:drug therapy*; D006801:Humans; D015552:Injections, Intralesional; D007834:Lasers; D008297:Male; D010778:Photochemotherapy / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D011446:Prospective Studies; D012008:Recurrence; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D017319:Photosensitizing Agents; D000622:Aminolevulinic Acid
keywords: 5 aminolevulinic acid; 630 nm Laser; Hidradenitis suppurativa; Intralesional photodynamic therapy; Intralesional treatment; Treatment