title: Synthesis and Single Crystal Structures of Substituted-1,3-Selenazol-2-amines.
abstract: The synthesis and X-ray single crystal structures of a series of new 4-substituted-1,3-selenazol-2-amines is reported. The efficient preparation of these compounds was carried out by two-component cyclization of the selenoureas with equimolar amounts of α-haloketones. The selenoureas were obtained from the reaction of Woollins' reagent with cyanamides, followed by hydrolysis with water. All new compounds have been characterized by IR spectroscopy, multi-NMR (¹H,13C,77Se) spectroscopy, accurate mass measurement and single crystal X-ray structure analysis.
authors.affiliation: EaStCHEM School of Chemistry, University of St. Andrews, St. Andrews, Fife KY16 9ST, UK. gh15@st-andrews.ac.uk.
authors.forename: Guoxiong
authors.initials: G
authors.lastname: Hua
authors.affiliation: EaStCHEM School of Chemistry, University of St. Andrews, St. Andrews, Fife KY16 9ST, UK. liangfengzhiyi@163.com.
authors.forename: Junyi
authors.initials: J
authors.lastname: Du
authors.affiliation: EaStCHEM School of Chemistry, University of St. Andrews, St. Andrews, Fife KY16 9ST, UK. amzs@st-andrews.ac.uk.
authors.forename: Alexandra M Z
authors.initials: AM
authors.lastname: Slawin
authors.affiliation: EaStCHEM School of Chemistry, University of St. Andrews, St. Andrews, Fife KY16 9ST, UK. jdw3@st-andrews.ac.uk.
authors.forename: J Derek
authors.initials: JD
authors.lastname: Woollins
mesh_terms: D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry*; D018360:Crystallography, X-Ray; D007659:Ketones / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D016566:Organoselenium Compounds / Q000737:chemistry; D014508:Urea / Q000031:analogs & derivatives / Q000737:chemistry
chemical_list: D000588:Amines; D007659:Ketones; D016566:Organoselenium Compounds; C081959:selenourea; D014508:Urea
keywords: Woollins’ reagent; cyanamides; haloketones; selenazol-2-amines; selenoureas