title: Monascustin, an Unusual γ-Lactam from Red Yeast Rice.
abstract: Monascustin (1), an unusual γ-lactam, was isolated from an ethanol extract of the Monascus purpureus fermented rice. Its structure including the absolute configuration was determined by spectroscopic data analysis and confirmed by X-ray crystallography. A plausible biosynthetic pathway is discussed on the basis of amino acid derivatization. Compound 1 showed inhibitory activity against histone deacetylase 1.
authors.affiliation: Beiijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University , Beijing 100191, People's Republic of China.
authors.forename: Wendi
authors.initials: W
authors.lastname: Wei
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050, People's Republic of China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Lin
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050, People's Republic of China.
authors.forename: Minghua
authors.initials: M
authors.lastname: Chen
authors.affiliation: Lanzhou University First Affiliated Hospital , Gansu 730000, People's Republic of China.
authors.forename: Tianxi
authors.initials: T
authors.lastname: Liu
authors.affiliation: Beiijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University , Beijing 100191, People's Republic of China.
authors.forename: Ali
authors.initials: A
authors.lastname: Wang
authors.affiliation: Beiijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University , Beijing 100191, People's Republic of China.
authors.forename: Jinjie
authors.initials: J
authors.lastname: Li
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050, People's Republic of China.
authors.forename: Qinglan
authors.initials: Q
authors.lastname: Guo
authors.affiliation: Beiijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University , Beijing 100191, People's Republic of China.
authors.forename: Xiaoya
authors.identifier: 0000-0003-2193-1712
authors.initials: X
authors.lastname: Shang
mesh_terms: D001688:Biological Products / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D006655:Histone Deacetylases / Q000737:chemistry / Q000187:drug effects*; D007769:Lactams / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D032741:Monascus / Q000737:chemistry*
chemical_list: D001688:Biological Products; D004791:Enzyme Inhibitors; D007769:Lactams; C000621744:monascustin; C117343:red yeast rice; D006655:Histone Deacetylases