title: High Dietary Fructose Intake on Cardiovascular Disease Related Parameters in Growing Rats.
abstract: The objective of this study was to determine the effects of a high-fructose diet on cardiovascular disease (CVD)-related parameters in growing rats. Three-week-old female Sprague Dawley rats were randomly assigned to four experimental groups; a regular diet group (RD: fed regular diet based on AIN-93G,n= 8), a high-fructose diet group (30Frc: fed regular diet with 30% fructose,n= 8), a high-fat diet group (45Fat: fed regular diet with 45 kcal% fat,n= 8) or a high fructose with high-fat diet group (30Frc + 45Fat, fed diet 30% fructose with 45 kcal% fat,n= 8). After an eight-week treatment period, the body weight, total-fat weight, serum glucose, insulin, lipid profiles and pro-inflammatory cytokines, abdominal aortic wall thickness, and expressions of eNOS and ET-1 mRNA were analyzed. The result showed that total-fat weight was higher in the 30Frc, 45Fat, and 30Frc + 45Fat groups compared to the RD group (p< 0.05). Serum triglyceride (TG) levels were highest in the 30Frc group than the other groups (p< 0.05). The abdominal aorta of 30Frc, 45Fat, and 30Frc + 45Fat groups had higher wall thickness than the RD group (p< 0.05). Abdominal aortic eNOS mRNA level was decreased in 30Frc, 45Fat, and 30Frc + 45Fat groups compared to the RD group (p< 0.05), and also 45Fat and 30Frc + 45Fat groups had decreased mRNA expression of eNOS compared to the 30Frc group (p< 0.05). ET-1 mRNA level was higher in 30Frc, 45Fat, and 30Frc + 45Fat groups than the RD group (p< 0.05). Both high fructose consumption and high fat consumption in growing rats had similar negative effects on CVD-related parameters.
authors.affiliation: Department of Medical Nutrition, Kyung Hee University, 1732 Deogyeong-daero, Giheung-gu, Yongin 17104, Korea. sooyeon928@hanmail.net.
authors.forename: SooYeon
authors.initials: S
authors.lastname: Yoo
authors.affiliation: Department of Medical Nutrition, Kyung Hee University, 1732 Deogyeong-daero, Giheung-gu, Yongin 17104, Korea. hjahn@khu.ac.kr.
authors.forename: Hyejin
authors.initials: H
authors.lastname: Ahn
authors.affiliation: Department of Medical Nutrition, Kyung Hee University, 1732 Deogyeong-daero, Giheung-gu, Yongin 17104, Korea. ypark@khu.ac.kr.|Research Institute of Medical Nutrition, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea. ypark@khu.ac.kr.
authors.forename: Yoo Kyoung
authors.initials: YK
authors.lastname: Park
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D002318:Cardiovascular Diseases / Q000503:physiopathology*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D059305:Diet, High-Fat; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D004041:Dietary Fats / Q000008:administration & dosage; D004044:Dietary Proteins / Q000008:administration & dosage; D002149:Energy Intake; D005260:Female; D005632:Fructose / Q000008:administration & dosage* / Q000009:adverse effects; D007328:Insulin / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D052250:Nitric Oxide Synthase Type III / Q000235:genetics / Q000378:metabolism; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D014280:Triglycerides / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004044:Dietary Proteins; D007328:Insulin; D015850:Interleukin-6; D017395:Plasminogen Activator Inhibitor 1; D012333:RNA, Messenger; D014280:Triglycerides; D014409:Tumor Necrosis Factor-alpha; D005632:Fructose; D052250:Nitric Oxide Synthase Type III; C496316:Nos3 protein, rat
keywords: cardiovascular disease (CVD); growing rat; high fructose diet