title: SRC-1 Regulates Blood Pressure and Aortic Stiffness in Female Mice.
abstract: Framingham Heart Study suggests that dysfunction of steroid receptor coactivator-1 may be involved in the development of hypertension. However, there is no functional evidence linking steroid receptor coactivator-1 to the regulation of blood pressure. We used immunohistochemistry to map the expression of steroid receptor coactivator-1 protein in mouse brain, especially in regions implicated in the regulation of blood pressure. Steroid receptor coactivator-1 protein was found in central amygdala, medial amygdala, supraoptic nucleus, arcuate nucleus, ventromedial, dorsomedial, paraventricular hypothalamus, and nucleus of the solitary tract. To determine the effects of steroid receptor coactivator-1 protein on cardiovascular system we measured blood pressures, blood flow velocities, echocardiographic parameters, and aortic input impedance in female steroid receptor coactivator-1 knockout mice and their wild type littermates. Steroid receptor coactivator-1 knockout mice had higher blood pressures and increased aortic stiffness when compared to female wild type littermates. Additionally, the hearts of steroid receptor coactivator-1 knockout mice seem to consume higher energy as evidenced by increased impedance and higher heart rate pressure product when compared to female wild type littermates. Our results demonstrate that steroid receptor coactivator-1 may be functionally involved in the regulation of blood pressure and aortic stiffness through the regulation of sympathetic activation in various neuronal populations.
authors.affiliation: Pediatrics-Children's Nutrition Research Center, Baylor College of Medicine, Houston, Texas, United States of America.
authors.forename: Antentor Othrell
authors.initials: AO
authors.lastname: Hinton
authors.affiliation: Pediatrics-Children's Nutrition Research Center, Baylor College of Medicine, Houston, Texas, United States of America.
authors.forename: Yongjie
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas, United States of America.|Cardiovascular Research Institute, Baylor College of Medicine, Houston, Texas, United States of America.
authors.forename: Ann P
authors.initials: AP
authors.lastname: Quick
authors.affiliation: Pediatrics-Children's Nutrition Research Center, Baylor College of Medicine, Houston, Texas, United States of America.
authors.forename: Pingwen
authors.initials: P
authors.lastname: Xu
authors.affiliation: Debakey High School for Health Professions, Houston, Texas, United States of America.
authors.forename: Chitra L
authors.initials: CL
authors.lastname: Reddy
authors.affiliation: Pediatrics-Children's Nutrition Research Center, Baylor College of Medicine, Houston, Texas, United States of America.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Yan
authors.affiliation: Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas, United States of America.|Cardiovascular Research Institute, Baylor College of Medicine, Houston, Texas, United States of America.|Advanced Technology/Core Laboratory, Baylor College of Medicine, Houston, Texas, United States of America.
authors.forename: Corey L
authors.initials: CL
authors.lastname: Reynolds
authors.affiliation: Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, United States of America.
authors.forename: Qingchun
authors.initials: Q
authors.lastname: Tong
authors.affiliation: Department of Gastroenterology, Union Hospital, Tongji Medical College and Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Liangru
authors.initials: L
authors.lastname: Zhu
authors.affiliation: Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America.
authors.forename: Jianming
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas, United States of America.|Cardiovascular Research Institute, Baylor College of Medicine, Houston, Texas, United States of America.
authors.forename: Xander H T
authors.initials: XH
authors.lastname: Wehrens
authors.affiliation: Pediatrics-Children's Nutrition Research Center, Baylor College of Medicine, Houston, Texas, United States of America.|Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America.
authors.forename: Yong
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Cardiovascular Research Institute, Baylor College of Medicine, Houston, Texas, United States of America.|Section of Cardiovascular Research, Department Medicine and DeBakey Heart Center, Baylor College of Medicine, Houston, Texas, United States of America.|Indus Instruments, Webster, Texas, United States of America.
authors.forename: Anilkumar K
authors.initials: AK
authors.lastname: Reddy
mesh_terms: D000818:Animals; D001794:Blood Pressure; D004452:Echocardiography; D005260:Female; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D056920:Nuclear Receptor Coactivator 1 / Q000502:physiology*; D059289:Vascular Stiffness / Q000502:physiology*
chemical_list: C538861:Ncoa1 protein, mouse; D056920:Nuclear Receptor Coactivator 1