title: Dietary restriction and lifespan: Lessons from invertebrate models.
abstract: Dietary restriction (DR) is the most robust environmental manipulation known to increase active and healthy lifespan in many species. Despite differences in the protocols and the way DR is carried out in different organisms, conserved relationships are emerging among multiple species. Elegant studies from numerous model organisms are further defining the importance of various nutrient-signaling pathways including mTOR (mechanistic target of rapamycin), insulin/IGF-1-like signaling and sirtuins in mediating the effects of DR. We here review current advances in our understanding of the molecular mechanisms altered by DR to promote lifespan in three major invertebrate models, the budding yeast Saccharomyces cerevisiae, the nematode Caenorhabditis elegans, and the fruit fly Drosophila melanogaster.
authors.affiliation: Buck Institute for Research on Aging, Novato, CA, USA.
authors.forename: Pankaj
authors.initials: P
authors.lastname: Kapahi
authors.affiliation: Department of Pathology, University of Washington, Seattle, WA, USA.
authors.forename: Matt
authors.initials: M
authors.lastname: Kaeberlein
authors.affiliation: Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA. Electronic address: mhansen@sbpdiscovery.org.
authors.forename: Malene
authors.initials: M
authors.lastname: Hansen
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans; D031204:Caloric Restriction; D004330:Drosophila / Q000378:metabolism; D004331:Drosophila melanogaster; D007328:Insulin; D007334:Insulin-Like Growth Factor I; D008136:Longevity; D023421:Models, Animal; D011994:Recombinant Proteins; D012441:Saccharomyces cerevisiae; D015398:Signal Transduction; D037761:Sirtuins / Q000378:metabolism; D058570:TOR Serine-Threonine Kinases
chemical_list: C583557:IGF1 protein, human; D007328:Insulin; D011994:Recombinant Proteins; D007334:Insulin-Like Growth Factor I; C000604197:mecasermin; C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases; D037761:Sirtuins
keywords: Autophagy; Flies; Metabolism; Mitochondrial respiration; Sirtuins; Worms; Yeast