title: Extracellular vesicles in liver diseases.
abstract: Extracellular vesicles (EVs) are membrane-bound vesicles that are released by cells into their extracellular environment, have selective enrichment of specific proteins and RNA, and can mediate intercellular communication. In this review we highlight recent observations of the role of EVs in liver injury, viral hepatitis, alcoholic or nonalcoholic liver disease, biliary tract disease, and liver cancers. Potential applications as markers of diseases or for therapeutic applications are outlined to emphasize the new opportunities that are arising from the study of EVs.
authors.affiliation: Department of Transplantation and Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida.
authors.forename: Sayantan
authors.initials: S
authors.lastname: Maji
authors.affiliation: Department of Transplantation and Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida.
authors.forename: Akiko
authors.initials: A
authors.lastname: Matsuda
authors.affiliation: Department of Transplantation and Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida.
authors.forename: Irene K
authors.initials: IK
authors.lastname: Yan
authors.affiliation: Department of Transplantation and Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida.
authors.forename: Mansi
authors.initials: M
authors.lastname: Parasramka
authors.affiliation: Department of Transplantation and Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida patel.tushar@mayo.edu.
authors.forename: Tushar
authors.initials: T
authors.lastname: Patel
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D002450:Cell Communication / Q000502:physiology*; D055354:Exosomes / Q000378:metabolism; D000067128:Extracellular Vesicles / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000378:metabolism*; D008107:Liver Diseases / Q000378:metabolism*; D035683:MicroRNAs / Q000378:metabolism
chemical_list: D015415:Biomarkers; D035683:MicroRNAs
keywords: cancer; extracellular vesicles; liver diseases; microRNA