title: Resolving the cadherin-F-actin connection.
abstract: Cadherin adhesion complexes have recently emerged as sensors of tissue tension that regulate key developmental processes. Super-resolution microscopy experiments now unravel the spatial organization of the interface between cadherins and the actin cytoskeleton and reveal how vinculin, a central component in cadherin mechanotransduction, is regulated by mechanical and biochemical signals.
authors.affiliation: Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, 3584 CG, Utrecht, The Netherlands.
authors.forename: Mitchell K L
authors.initials: MK
authors.lastname: Han
authors.affiliation: Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, 3584 CG, Utrecht, The Netherlands.
authors.forename: Johan
authors.initials: J
authors.lastname: de Rooij
mesh_terms: D008841:Actin Cytoskeleton / Q000378:metabolism; D000199:Actins / Q000378:metabolism*; D000205:Actomyosin / Q000378:metabolism; D000818:Animals; D015820:Cadherins / Q000378:metabolism*; D002448:Cell Adhesion; D051379:Mice; D008954:Models, Biological
chemical_list: D000199:Actins; D015820:Cadherins; D000205:Actomyosin