title: [Pancreatic cancer microenvironment].
abstract: Pancreatic cancer remains one of the deadliest solid tumors in humans and an unsolved problem of today's medicine. Experimental studies reveal that the heterogeneous and complex pancreatic cancer microenvironment is responsible, not only for cancer growth, spread, development of metastases, but also for cancer recurrence and chemotherapy resistance. Chemotherapy affecting the cancer stroma is still under clinical and experimental research and remains hope for cure of pancreatic cancer. We present the cancer microenvironment characteristics and summary of experimental studies with use of agents affecting pancreatic cancer stroma.
authors.affiliation: Pomeranian Medical University of Szczecin, Poland: Department of Gastroenterology.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Dąbkowski
authors.affiliation: Pomeranian Medical University of Szczecin, Poland: Department of Gastroenterology.
authors.forename: Barbara
authors.initials: B
authors.lastname: Bogacka
authors.affiliation: Pomeranian Medical University of Szczecin, Poland: Department of Physiology.
authors.forename: Maciej
authors.initials: M
authors.lastname: Tarnowski
authors.affiliation: Pomeranian Medical University of Szczecin, Poland: Department of Gastroenterology.
authors.forename: Teresa
authors.initials: T
authors.lastname: Starzyńska
mesh_terms: D019008:Drug Resistance, Neoplasm; D006801:Humans; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D010190:Pancreatic Neoplasms / Q000473:pathology / Q000503:physiopathology*; D059016:Tumor Microenvironment
keywords: pancreatic cancer; pancreatic stellate cells; tumor microenvironment