title: Renal transplantation outcomes following heart and heart-lung transplantation.
abstract: BACKGROUND
  Chronic kidney disease is a frequent complication following heart and combined heart-lung transplantation. The aim of this study was to analyse the outcome of a subsequent renal transplant in heart, lung and heart-lung transplantation recipients.
  
  
  METHODS
  All heart, lung and heart-lung transplant recipients who received a subsequent renal transplant over a 27-year period in a national heart and lung transplant centre were included in this study.
  
  
  RESULTS
  A total of 18 patients who had previously undergone heart (n = 6), lung (n = 7) and heart-lung (n = 5) transplantation received a renal transplant. The mean duration to development of end-stage kidney disease (ESKD) was 115 ± 45.9 months. The most common contributor to ESKD was calcineurin inhibitor nephrotoxicity. The 5-year patient survival and graft survival rates were 91.7 and 85.6%, respectively. The median creatinine level at the most recent follow-up was 123 μmol/L, IQR 90.8-147.5.
  
  
  CONCLUSIONS
  The overall outcome of renal transplantation following previous non-renal solid organ transplantation is excellent considering the medical complexity and co-morbidities of this patient population. Renal transplantation represents an important treatment option for ESKD in non-renal solid organ transplant recipients.
authors.affiliation: Department of Nephrology, Mater Misericordiae University Hospital, Eccles Street, Dublin 7, Ireland. limywong@gmail.com.
authors.forename: L
authors.initials: L
authors.lastname: Wong
authors.affiliation: Department of Cardiothoracic Surgery, Mater Misericordiae University Hospital, Dublin, Ireland.
authors.forename: Y R
authors.initials: YR
authors.lastname: Chee
authors.affiliation: Department of Cardiothoracic Surgery, Mater Misericordiae University Hospital, Dublin, Ireland.
authors.forename: D G
authors.initials: DG
authors.lastname: Healy
authors.affiliation: Department of Respiratory Medicine, Mater Misericordiae University Hospital, Dublin, Ireland.
authors.forename: J J
authors.initials: JJ
authors.lastname: Egan
authors.affiliation: Department of Nephrology, Mater Misericordiae University Hospital, Eccles Street, Dublin 7, Ireland.
authors.forename: D M
authors.initials: DM
authors.lastname: Sadlier
authors.affiliation: Department of Nephrology, Mater Misericordiae University Hospital, Eccles Street, Dublin 7, Ireland.
authors.forename: Y M
authors.initials: YM
authors.lastname: O'Meara
mesh_terms: D005260:Female; D016027:Heart Transplantation / Q000379:methods* / Q000401:mortality; D016041:Heart-Lung Transplantation / Q000379:methods* / Q000401:mortality; D006801:Humans; D016030:Kidney Transplantation / Q000379:methods* / Q000401:mortality; D008297:Male; D051436:Renal Insufficiency, Chronic / Q000209:etiology*; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome
keywords: Heart; Lung; Outcomes; Renal transplant