title: Selective Aryne Formation via Grob Fragmentation from the [2+2] Cycloadducts of 3-Triflyloxyarynes.
abstract: A chemoselective ring-opening protocol of the formal [2+2] cycloadducts of 3-triflyloxyarynes was developed to generate 2,3-aryne intermediate via Grob fragmentation. A variety of 1,3-di- and 1,2,3-trisubstituted arenes could be readily accessed through this [2+2] cycloaddition-2,3-aryne formation sequence. The regioselectivity in these transformations originates from the steric repulsion of the aliphatic chain.
authors.affiliation: School of Chemistry and Chemical Engineering, Chongqing University , 174 Shazheng Street, Chongqing 400030, P. R. China.
authors.forename: Jiarong
authors.initials: J
authors.lastname: Shi
authors.affiliation: School of Chemistry and Chemical Engineering, Chongqing University , 174 Shazheng Street, Chongqing 400030, P. R. China.
authors.forename: Hai
authors.initials: H
authors.lastname: Xu
authors.affiliation: School of Chemistry and Chemical Engineering, Chongqing University , 174 Shazheng Street, Chongqing 400030, P. R. China.
authors.forename: Dachuan
authors.initials: D
authors.lastname: Qiu
authors.affiliation: School of Chemistry and Chemical Engineering, Chongqing University , 174 Shazheng Street, Chongqing 400030, P. R. China.
authors.forename: Jia
authors.initials: J
authors.lastname: He
authors.affiliation: School of Chemistry and Chemical Engineering, Chongqing University , 174 Shazheng Street, Chongqing 400030, P. R. China.
authors.forename: Yang
authors.identifier: 0000-0002-0090-2894
authors.initials: Y
authors.lastname: Li