title: Recent advances on the encoding and selection methods of DNA-encoded chemical library.
abstract: DNA-encoded chemical library (DEL) has emerged as a powerful and versatile tool for ligand discovery in chemical biology research and in drug discovery. Encoding and selection methods are two of the most important technological aspects of DEL that can dictate the performance and utilities of DELs. In this digest, we have summarized recent advances on the encoding and selection strategies of DEL and also discussed the latest developments on DNA-encoded dynamic library, a new frontier in DEL research.
authors.affiliation: Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China; Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong Special Administrative Region.
authors.forename: Bingbing
authors.initials: B
authors.lastname: Shi
authors.affiliation: Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China; Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong Special Administrative Region.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong Special Administrative Region.
authors.forename: Yiran
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong Special Administrative Region.
authors.forename: Jianfu
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong Special Administrative Region. Electronic address: xiaoyuli@hku.hk.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Li
mesh_terms: D020650:Combinatorial Chemistry Techniques; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D055808:Drug Discovery; D057166:High-Throughput Screening Assays; D008024:Ligands; D009693:Nucleic Acid Hybridization; D054852:Small Molecule Libraries / Q000737:chemistry / Q000378:metabolism*
chemical_list: D008024:Ligands; D054852:Small Molecule Libraries; D004247:DNA
keywords: Combinatorial chemistry; DNA-encoded library; Drug discovery; Dynamic combinatorial library; High throughput screening