title: Prophylactic Total Gastrectomy for Hereditary Diffuse Gastric Cancer.
abstract: Germline mutations in theCDH1gene that produces E-cadherin have been implicated in the development of early-onset diffuse gastric cancer, termed hereditary diffuse gastric cancer. The mean age of gastric cancer diagnosis in affected individuals is 37 years. By age 80,CDH1mutation carriers who fulfill the clinical criteria for hereditary diffuse gastric cancer have an estimated lifetime risk of gastric cancer development of 67% for men and 83% for women. Data suggest that endoscopic surveillance for mutation carriers is largely ineffective. Prophylactic total gastrectomy between the ages of 18 and 40 years is recommended in carriers of germline-truncating E-cadherin mutations.
authors.affiliation: Department of Gastroenterology, Oklahoma State University, Tulsa, OK.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Shepard
authors.affiliation: Department of Gastroenterology, Cancer Treatment Centers of America, Schaumburg, IL.
authors.forename: Leon
authors.initials: L
authors.lastname: Yoder
authors.affiliation: Department of Pathology, Cancer Treatment Centers of America, Schaumburg, IL.
authors.forename: Cynthia
authors.initials: C
authors.lastname: Holmes