title: Using comparative biology to understand how aging affects mitochondrial metabolism.
abstract: Lifespan varies considerably among even closely related species, as exemplified by rodents and primates. Despite these disparities in lifespan, most studies have focused on intra-specific aging pathologies, primarily within a select few systems. While mice have provided much insight into aging biology, it is unclear if such a short-lived species lack defences against senescence that may have evolved in related longevous species. Many age-related diseases have been linked to mitochondrial dysfunction that are measured by decreased energy generation, structural damage to cellular components, and even cell death. Post translational modifications (PTMs) orchestrate many of the pathways associated with cellular metabolism, and are thought to be a key regulator in biological senescence. We propose hyperacylation as one such modification that may be implicated in numerous mitochondrial impairments affecting energy metabolism.
authors.affiliation: Department of Biomolecular Chemistry, University of Wisconsin- Madison, Madison, WI 53715, USA. Electronic address: rdhillon2@wisc.edu.
authors.forename: Rashpal S
authors.initials: RS
authors.lastname: Dhillon
authors.affiliation: Department of Biomolecular Chemistry, University of Wisconsin- Madison, Madison, WI 53715, USA.
authors.forename: John M
authors.initials: JM
authors.lastname: Denu
mesh_terms: D000215:Acylation; D000818:Animals; D031204:Caloric Restriction; D002952:Citric Acid Cycle / Q000235:genetics; D045222:Electron Transport Chain Complex Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008136:Longevity / Q000235:genetics*; D051379:Mice; D008928:Mitochondria / Q000378:metabolism*; D063154:Mitochondrial Dynamics / Q000235:genetics; D019577:Mole Rats / Q000235:genetics* / Q000254:growth & development; D011499:Protein Processing, Post-Translational; D056566:Sirtuin 3 / Q000235:genetics / Q000378:metabolism; D013045:Species Specificity
chemical_list: D045222:Electron Transport Chain Complex Proteins; C466093:SIRT3 protein, human; D056566:Sirtuin 3
keywords: Acylation; Aging; Comparative biology; Mitochondria; Mitochondria Aging.; Sirtuin 3