title: Relationship between first trimester aneuploidy screening test serum analytes and placenta accreta.
abstract: OBJECTIVE
  The aim of this study is to determine whether there is a relationship between first trimester serum pregnancy-associated plasma protein A (PAPP-A) and free beta human chorionic gonadotropin (fβhCG) MoM values and placenta accreta in women who had placenta previa.
  
  
  METHODS
  A total of 88 patients with placenta previa who had first trimester aneuploidy screening test results were enrolled in the study. Nineteen of these patients were also diagnosed with placenta accreta. As probable markers of excessive placental invasion, serum PAPP-A and fβhCG MoM values were compared in two groups with and without placenta accreta.
  
  
  RESULTS
  Patients with placenta accreta had higher statistically significant serum PAPP-A (1.20 versus 0.865, respectively, p = 0.045) and fβhCG MoM (1.42 versus 0.93, respectively, p = 0.042) values than patients without accreta.
  
  
  CONCLUSIONS
  Higher first trimester serum PAPP-A and fβhCG MoM values seem to be associated with placenta accreta in women with placenta previa. Further studies are needed to use these promising additional tools for early detection of placenta accreta.
authors.affiliation: a Department of Gynecology and Obstetrics, Kayseri Training and Research Hospital , Kayseri , Turkey.
authors.forename: Barış
authors.initials: B
authors.lastname: Büke
authors.affiliation: a Department of Gynecology and Obstetrics, Kayseri Training and Research Hospital , Kayseri , Turkey.
authors.forename: Hatice
authors.identifier: http://orcid.org/0000-0002-9613-1712
authors.initials: H
authors.lastname: Akkaya
authors.affiliation: b Department of Gynecology and Obstetrics , Aksaray Ortaköy State Hospital , Aksaray , Turkey.
authors.forename: Sibel
authors.initials: S
authors.lastname: Demir
authors.affiliation: c Obstetrics and Gynecology Clinic , Ege University Faculty of Medicine , İzmir , Turkey.
authors.forename: Sermet
authors.initials: S
authors.lastname: Sağol
authors.affiliation: c Obstetrics and Gynecology Clinic , Ege University Faculty of Medicine , İzmir , Turkey.
authors.forename: Deniz
authors.initials: D
authors.lastname: Şimşek
authors.affiliation: d Department of Biochemistry , Ege University Faculty of Medicine , İzmir , Turkey.
authors.forename: Güneş
authors.initials: G
authors.lastname: Başol
authors.affiliation: d Department of Biochemistry , Ege University Faculty of Medicine , İzmir , Turkey.
authors.forename: Burcu
authors.initials: B
authors.lastname: Barutçuoğlu
mesh_terms: D000328:Adult; D000782:Aneuploidy; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood*; D005260:Female; D006801:Humans; D008403:Mass Screening; D062145:Maternal Serum Screening Tests; D010921:Placenta Accreta / Q000097:blood*; D011247:Pregnancy; D011266:Pregnancy-Associated Plasma Protein-A / Q000378:metabolism*; D012189:Retrospective Studies
chemical_list: D018997:Chorionic Gonadotropin, beta Subunit, Human; D011266:Pregnancy-Associated Plasma Protein-A; C579283:PAPPA protein, human
keywords: PAPP-A; excessive placentation; fβhCG; morbidly adherent placenta; placenta accreta