title: Treatments and Outcomes of Patients With Extranodal Natural Killer/T-Cell Lymphoma Diagnosed Between 2000 and 2013: A Cooperative Study in Japan.
abstract: Purpose To elucidate the management and outcomes of patients with extranodal natural killer/T-cell lymphoma, nasal type (ENKL), who were diagnosed between 2000 and 2013 in Japan. Patients and Methods Data from 358 patients with ENKL diagnosed between 2000 and 2013 from 31 institutes were retrospectively analyzed. Results Patients' median age was 58 years, and 257 (72%) had localized disease. The most common first-line treatment was radiotherapy with dexamethasone, etoposide, ifosfamide, and carboplatin (RT-DeVIC) (66%) for localized ENKL and L-asparaginase-containing chemotherapy (30%) for advanced ENKL. With a median follow-up of 5.8 years, overall survival (OS) rates at 5 years for localized and advanced ENKL were 68% and 24%, respectively. The prognostic index of natural killer lymphoma was validated in our study, although only 4% of patients with localized ENKL were classified as high risk. With a median follow-up of 5.6 years, OS and progression-free survival at 5 years in the 150 patients who received RT-DeVIC in clinical practice were 72% (95% CI, 63% to 78%) and 61% (95% CI, 52% to 69%), respectively. Toxicities of RT-DeVIC were comparable to those in a previous trial. Multivariate analysis in patients with localized ENKL who received RT-DeVIC identified elevated soluble interleukin-2 receptor as an independent predictive factor for worse OS and progression-free survival (adjusted hazard ratios, 2.28 and 2.46; 95% CI, 1.24 to 4.23 and 1.42 to 4.28; P = .008 and .0014, respectively). Conclusion Favorable OS in response to new treatments was demonstrated in a large number of patients. Improved treatment approaches are needed for localized ENKL exhibiting elevated pretreatment soluble interleukin-2 receptor.
authors.affiliation: Motoko Yamaguchi, Kana Miyazaki, Noriko Ii, and Naoyuki Katayama, Mie University Graduate School of Medicine, Tsu; Ritsuro Suzuki, Shimane University Hospital, Izumo; Masahiko Oguchi and Kyoko Ueda, Cancer Institute Hospital of the Japanese Foundation for Cancer Research; Yukio Kobayashi and Jun Itami, National Cancer Center Hospital; Bungo Saito, Showa University School of Medicine, Tokyo; Naoko Asano, Nagano Prefectural Suzaka Hospital, Suzaka; Jun Amaki and Takeshi Akiba, Tokai University School of Medicine, Isehara; Takeshi Maeda and Satoshi Itasaka, Kurashiki Central Hospital, Kurashiki; Nobuko Kubota and Yoshihiro Saito, Saitama Cancer Center, Ina; Naoto Tomita, Yokohama City University Graduate School of Medicine, Yokohama; Nodoka Sekiguchi, Shinshu University School of Medicine, Matsumoto; Jun Takizawa, Niigata University Faculty of Medicine, Niigata; Tohru Murayama, Hyogo Cancer Center, Akashi; Toshihiko Ando, Saga University, Saga; Hideho Wada, Kawasaki Medical School, Kurashiki; Rie Hyo, Nagoya University Graduate School of Medicine, Nagoya; Yasuo Ejima, Kobe University, Kobe; and Masatoshi Hasegawa, Nara Medical University, Kashihara, Japan.
authors.forename: Motoko
authors.initials: M
authors.lastname: Yamaguchi
authors.affiliation: Motoko Yamaguchi, Kana Miyazaki, Noriko Ii, and Naoyuki Katayama, Mie University Graduate School of Medicine, Tsu; Ritsuro Suzuki, Shimane University Hospital, Izumo; Masahiko Oguchi and Kyoko Ueda, Cancer Institute Hospital of the Japanese Foundation for Cancer Research; Yukio Kobayashi and Jun Itami, National Cancer Center Hospital; Bungo Saito, Showa University School of Medicine, Tokyo; Naoko Asano, Nagano Prefectural Suzaka Hospital, Suzaka; Jun Amaki and Takeshi Akiba, Tokai University School of Medicine, Isehara; Takeshi Maeda and Satoshi Itasaka, Kurashiki Central Hospital, Kurashiki; Nobuko Kubota and Yoshihiro Saito, Saitama Cancer Center, Ina; Naoto Tomita, Yokohama City University Graduate School of Medicine, Yokohama; Nodoka Sekiguchi, Shinshu University School of Medicine, Matsumoto; Jun Takizawa, Niigata University Faculty of Medicine, Niigata; Tohru Murayama, Hyogo Cancer Center, Akashi; Toshihiko Ando, Saga University, Saga; Hideho Wada, Kawasaki Medical School, Kurashiki; Rie Hyo, Nagoya University Graduate School of Medicine, Nagoya; Yasuo Ejima, Kobe University, Kobe; and Masatoshi Hasegawa, Nara Medical University, Kashihara, Japan.
authors.forename: Ritsuro
authors.initials: R
authors.lastname: Suzuki
authors.affiliation: Motoko Yamaguchi, Kana Miyazaki, Noriko Ii, and Naoyuki Katayama, Mie University Graduate School of Medicine, Tsu; Ritsuro Suzuki, Shimane University Hospital, Izumo; Masahiko Oguchi and Kyoko Ueda, Cancer Institute Hospital of the Japanese Foundation for Cancer Research; Yukio Kobayashi and Jun Itami, National Cancer Center Hospital; Bungo Saito, Showa University School of Medicine, Tokyo; Naoko Asano, Nagano Prefectural Suzaka Hospital, Suzaka; Jun Amaki and Takeshi Akiba, Tokai University School of Medicine, Isehara; Takeshi Maeda and Satoshi Itasaka, Kurashiki Central Hospital, Kurashiki; Nobuko Kubota and Yoshihiro Saito, Saitama Cancer Center, Ina; Naoto Tomita, Yokohama City University Graduate School of Medicine, Yokohama; Nodoka Sekiguchi, Shinshu University School of Medicine, Matsumoto; Jun Takizawa, Niigata University Faculty of Medicine, Niigata; Tohru Murayama, Hyogo Cancer Center, Akashi; Toshihiko Ando, Saga University, Saga; Hideho Wada, Kawasaki Medical School, Kurashiki; Rie Hyo, Nagoya University Graduate School of Medicine, Nagoya; Yasuo Ejima, Kobe University, Kobe; and Masatoshi Hasegawa, Nara Medical University, Kashihara, Japan.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Oguchi
authors.affiliation: Motoko Yamaguchi, Kana Miyazaki, Noriko Ii, and Naoyuki Katayama, Mie University Graduate School of Medicine, Tsu; Ritsuro Suzuki, Shimane University Hospital, Izumo; Masahiko Oguchi and Kyoko Ueda, Cancer Institute Hospital of the Japanese Foundation for Cancer Research; Yukio Kobayashi and Jun Itami, National Cancer Center Hospital; Bungo Saito, Showa University School of Medicine, Tokyo; Naoko Asano, Nagano Prefectural Suzaka Hospital, Suzaka; Jun Amaki and Takeshi Akiba, Tokai University School of Medicine, Isehara; Takeshi Maeda and Satoshi Itasaka, Kurashiki Central Hospital, Kurashiki; Nobuko Kubota and Yoshihiro Saito, Saitama Cancer Center, Ina; Naoto Tomita, Yokohama City University Graduate School of Medicine, Yokohama; Nodoka Sekiguchi, Shinshu University School of Medicine, Matsumoto; Jun Takizawa, Niigata University Faculty of Medicine, Niigata; Tohru Murayama, Hyogo Cancer Center, Akashi; Toshihiko Ando, Saga University, Saga; Hideho Wada, Kawasaki Medical School, Kurashiki; Rie Hyo, Nagoya University Graduate School of Medicine, Nagoya; Yasuo Ejima, Kobe University, Kobe; and Masatoshi Hasegawa, Nara Medical University, Kashihara, Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Asano
authors.affiliation: Motoko Yamaguchi, Kana Miyazaki, Noriko Ii, and Naoyuki Katayama, Mie University Graduate School of Medicine, Tsu; Ritsuro Suzuki, Shimane University Hospital, Izumo; Masahiko Oguchi and Kyoko Ueda, Cancer Institute Hospital of the Japanese Foundation for Cancer Research; Yukio Kobayashi and Jun Itami, National Cancer Center Hospital; Bungo Saito, Showa University School of Medicine, Tokyo; Naoko Asano, Nagano Prefectural Suzaka Hospital, Suzaka; Jun Amaki and Takeshi Akiba, Tokai University School of Medicine, Isehara; Takeshi Maeda and Satoshi Itasaka, Kurashiki Central Hospital, Kurashiki; Nobuko Kubota and Yoshihiro Saito, Saitama Cancer Center, Ina; Naoto Tomita, Yokohama City University Graduate School of Medicine, Yokohama; Nodoka Sekiguchi, Shinshu University School of Medicine, Matsumoto; Jun Takizawa, Niigata University Faculty of Medicine, Niigata; Tohru Murayama, Hyogo Cancer Center, Akashi; Toshihiko Ando, Saga University, Saga; Hideho Wada, Kawasaki Medical School, Kurashiki; Rie Hyo, Nagoya University Graduate School of Medicine, Nagoya; Yasuo Ejima, Kobe University, Kobe; and Masatoshi Hasegawa, Nara Medical University, Kashihara, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Amaki
authors.affiliation: Motoko Yamaguchi, Kana Miyazaki, Noriko Ii, and Naoyuki Katayama, Mie University Graduate School of Medicine, Tsu; Ritsuro Suzuki, Shimane University Hospital, Izumo; Masahiko Oguchi and Kyoko Ueda, Cancer Institute Hospital of the Japanese Foundation for Cancer Research; Yukio Kobayashi and Jun Itami, National Cancer Center Hospital; Bungo Saito, Showa University School of Medicine, Tokyo; Naoko Asano, Nagano Prefectural Suzaka Hospital, Suzaka; Jun Amaki and Takeshi Akiba, Tokai University School of Medicine, Isehara; Takeshi Maeda and Satoshi Itasaka, Kurashiki Central Hospital, Kurashiki; Nobuko Kubota and Yoshihiro Saito, Saitama Cancer Center, Ina; Naoto Tomita, Yokohama City University Graduate School of Medicine, Yokohama; Nodoka Sekiguchi, Shinshu University School of Medicine, Matsumoto; Jun Takizawa, Niigata University Faculty of Medicine, Niigata; Tohru Murayama, Hyogo Cancer Center, Akashi; Toshihiko Ando, Saga University, Saga; Hideho Wada, Kawasaki Medical School, Kurashiki; Rie Hyo, Nagoya University Graduate School of Medicine, Nagoya; Yasuo Ejima, Kobe University, Kobe; and Masatoshi Hasegawa, Nara Medical University, Kashihara, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Akiba
authors.affiliation: Motoko Yamaguchi, Kana Miyazaki, Noriko Ii, and Naoyuki Katayama, Mie University Graduate School of Medicine, Tsu; Ritsuro Suzuki, Shimane University Hospital, Izumo; Masahiko Oguchi and Kyoko Ueda, Cancer Institute Hospital of the Japanese Foundation for Cancer Research; Yukio Kobayashi and Jun Itami, National Cancer Center Hospital; Bungo Saito, Showa University School of Medicine, Tokyo; Naoko Asano, Nagano Prefectural Suzaka Hospital, Suzaka; Jun Amaki and Takeshi Akiba, Tokai University School of Medicine, Isehara; Takeshi Maeda and Satoshi Itasaka, Kurashiki Central Hospital, Kurashiki; Nobuko Kubota and Yoshihiro Saito, Saitama Cancer Center, Ina; Naoto Tomita, Yokohama City University Graduate School of Medicine, Yokohama; Nodoka Sekiguchi, Shinshu University School of Medicine, Matsumoto; Jun Takizawa, Niigata University Faculty of Medicine, Niigata; Tohru Murayama, Hyogo Cancer Center, Akashi; Toshihiko Ando, Saga University, Saga; Hideho Wada, Kawasaki Medical School, Kurashiki; Rie Hyo, Nagoya University Graduate School of Medicine, Nagoya; Yasuo Ejima, Kobe University, Kobe; and Masatoshi Hasegawa, Nara Medical University, Kashihara, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Maeda
authors.affiliation: Motoko Yamaguchi, Kana Miyazaki, Noriko Ii, and Naoyuki Katayama, Mie University Graduate School of Medicine, Tsu; Ritsuro Suzuki, Shimane University Hospital, Izumo; Masahiko Oguchi and Kyoko Ueda, Cancer Institute Hospital of the Japanese Foundation for Cancer Research; Yukio Kobayashi and Jun Itami, National Cancer Center Hospital; Bungo Saito, Showa University School of Medicine, Tokyo; Naoko Asano, Nagano Prefectural Suzaka Hospital, Suzaka; Jun Amaki and Takeshi Akiba, Tokai University School of Medicine, Isehara; Takeshi Maeda and Satoshi Itasaka, Kurashiki Central Hospital, Kurashiki; Nobuko Kubota and Yoshihiro Saito, Saitama Cancer Center, Ina; Naoto Tomita, Yokohama City University Graduate School of Medicine, Yokohama; Nodoka Sekiguchi, Shinshu University School of Medicine, Matsumoto; Jun Takizawa, Niigata University Faculty of Medicine, Niigata; Tohru Murayama, Hyogo Cancer Center, Akashi; Toshihiko Ando, Saga University, Saga; Hideho Wada, Kawasaki Medical School, Kurashiki; Rie Hyo, Nagoya University Graduate School of Medicine, Nagoya; Yasuo Ejima, Kobe University, Kobe; and Masatoshi Hasegawa, Nara Medical University, Kashihara, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Itasaka
authors.affiliation: Motoko Yamaguchi, Kana Miyazaki, Noriko Ii, and Naoyuki Katayama, Mie University Graduate School of Medicine, Tsu; Ritsuro Suzuki, Shimane University Hospital, Izumo; Masahiko Oguchi and Kyoko Ueda, Cancer Institute Hospital of the Japanese Foundation for Cancer Research; Yukio Kobayashi and Jun Itami, National Cancer Center Hospital; Bungo Saito, Showa University School of Medicine, Tokyo; Naoko Asano, Nagano Prefectural Suzaka Hospital, Suzaka; Jun Amaki and Takeshi Akiba, Tokai University School of Medicine, Isehara; Takeshi Maeda and Satoshi Itasaka, Kurashiki Central Hospital, Kurashiki; Nobuko Kubota and Yoshihiro Saito, Saitama Cancer Center, Ina; Naoto Tomita, Yokohama City University Graduate School of Medicine, Yokohama; Nodoka Sekiguchi, Shinshu University School of Medicine, Matsumoto; Jun Takizawa, Niigata University Faculty of Medicine, Niigata; Tohru Murayama, Hyogo Cancer Center, Akashi; Toshihiko Ando, Saga University, Saga; Hideho Wada, Kawasaki Medical School, Kurashiki; Rie Hyo, Nagoya University Graduate School of Medicine, Nagoya; Yasuo Ejima, Kobe University, Kobe; and Masatoshi Hasegawa, Nara Medical University, Kashihara, Japan.
authors.forename: Nobuko
authors.initials: N
authors.lastname: Kubota
authors.affiliation: Motoko Yamaguchi, Kana Miyazaki, Noriko Ii, and Naoyuki Katayama, Mie University Graduate School of Medicine, Tsu; Ritsuro Suzuki, Shimane University Hospital, Izumo; Masahiko Oguchi and Kyoko Ueda, Cancer Institute Hospital of the Japanese Foundation for Cancer Research; Yukio Kobayashi and Jun Itami, National Cancer Center Hospital; Bungo Saito, Showa University School of Medicine, Tokyo; Naoko Asano, Nagano Prefectural Suzaka Hospital, Suzaka; Jun Amaki and Takeshi Akiba, Tokai University School of Medicine, Isehara; Takeshi Maeda and Satoshi Itasaka, Kurashiki Central Hospital, Kurashiki; Nobuko Kubota and Yoshihiro Saito, Saitama Cancer Center, Ina; Naoto Tomita, Yokohama City University Graduate School of Medicine, Yokohama; Nodoka Sekiguchi, Shinshu University School of Medicine, Matsumoto; Jun Takizawa, Niigata University Faculty of Medicine, Niigata; Tohru Murayama, Hyogo Cancer Center, Akashi; Toshihiko Ando, Saga University, Saga; Hideho Wada, Kawasaki Medical School, Kurashiki; Rie Hyo, Nagoya University Graduate School of Medicine, Nagoya; Yasuo Ejima, Kobe University, Kobe; and Masatoshi Hasegawa, Nara Medical University, Kashihara, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Saito
authors.affiliation: Motoko Yamaguchi, Kana Miyazaki, Noriko Ii, and Naoyuki Katayama, Mie University Graduate School of Medicine, Tsu; Ritsuro Suzuki, Shimane University Hospital, Izumo; Masahiko Oguchi and Kyoko Ueda, Cancer Institute Hospital of the Japanese Foundation for Cancer Research; Yukio Kobayashi and Jun Itami, National Cancer Center Hospital; Bungo Saito, Showa University School of Medicine, Tokyo; Naoko Asano, Nagano Prefectural Suzaka Hospital, Suzaka; Jun Amaki and Takeshi Akiba, Tokai University School of Medicine, Isehara; Takeshi Maeda and Satoshi Itasaka, Kurashiki Central Hospital, Kurashiki; Nobuko Kubota and Yoshihiro Saito, Saitama Cancer Center, Ina; Naoto Tomita, Yokohama City University Graduate School of Medicine, Yokohama; Nodoka Sekiguchi, Shinshu University School of Medicine, Matsumoto; Jun Takizawa, Niigata University Faculty of Medicine, Niigata; Tohru Murayama, Hyogo Cancer Center, Akashi; Toshihiko Ando, Saga University, Saga; Hideho Wada, Kawasaki Medical School, Kurashiki; Rie Hyo, Nagoya University Graduate School of Medicine, Nagoya; Yasuo Ejima, Kobe University, Kobe; and Masatoshi Hasegawa, Nara Medical University, Kashihara, Japan.
authors.forename: Yukio
authors.initials: Y
authors.lastname: Kobayashi
authors.affiliation: Motoko Yamaguchi, Kana Miyazaki, Noriko Ii, and Naoyuki Katayama, Mie University Graduate School of Medicine, Tsu; Ritsuro Suzuki, Shimane University Hospital, Izumo; Masahiko Oguchi and Kyoko Ueda, Cancer Institute Hospital of the Japanese Foundation for Cancer Research; Yukio Kobayashi and Jun Itami, National Cancer Center Hospital; Bungo Saito, Showa University School of Medicine, Tokyo; Naoko Asano, Nagano Prefectural Suzaka Hospital, Suzaka; Jun Amaki and Takeshi Akiba, Tokai University School of Medicine, Isehara; Takeshi Maeda and Satoshi Itasaka, Kurashiki Central Hospital, Kurashiki; Nobuko Kubota and Yoshihiro Saito, Saitama Cancer Center, Ina; Naoto Tomita, Yokohama City University Graduate School of Medicine, Yokohama; Nodoka Sekiguchi, Shinshu University School of Medicine, Matsumoto; Jun Takizawa, Niigata University Faculty of Medicine, Niigata; Tohru Murayama, Hyogo Cancer Center, Akashi; Toshihiko Ando, Saga University, Saga; Hideho Wada, Kawasaki Medical School, Kurashiki; Rie Hyo, Nagoya University Graduate School of Medicine, Nagoya; Yasuo Ejima, Kobe University, Kobe; and Masatoshi Hasegawa, Nara Medical University, Kashihara, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Itami
authors.affiliation: Motoko Yamaguchi, Kana Miyazaki, Noriko Ii, and Naoyuki Katayama, Mie University Graduate School of Medicine, Tsu; Ritsuro Suzuki, Shimane University Hospital, Izumo; Masahiko Oguchi and Kyoko Ueda, Cancer Institute Hospital of the Japanese Foundation for Cancer Research; Yukio Kobayashi and Jun Itami, National Cancer Center Hospital; Bungo Saito, Showa University School of Medicine, Tokyo; Naoko Asano, Nagano Prefectural Suzaka Hospital, Suzaka; Jun Amaki and Takeshi Akiba, Tokai University School of Medicine, Isehara; Takeshi Maeda and Satoshi Itasaka, Kurashiki Central Hospital, Kurashiki; Nobuko Kubota and Yoshihiro Saito, Saitama Cancer Center, Ina; Naoto Tomita, Yokohama City University Graduate School of Medicine, Yokohama; Nodoka Sekiguchi, Shinshu University School of Medicine, Matsumoto; Jun Takizawa, Niigata University Faculty of Medicine, Niigata; Tohru Murayama, Hyogo Cancer Center, Akashi; Toshihiko Ando, Saga University, Saga; Hideho Wada, Kawasaki Medical School, Kurashiki; Rie Hyo, Nagoya University Graduate School of Medicine, Nagoya; Yasuo Ejima, Kobe University, Kobe; and Masatoshi Hasegawa, Nara Medical University, Kashihara, Japan.
authors.forename: Kyoko
authors.initials: K
authors.lastname: Ueda
authors.affiliation: Motoko Yamaguchi, Kana Miyazaki, Noriko Ii, and Naoyuki Katayama, Mie University Graduate School of Medicine, Tsu; Ritsuro Suzuki, Shimane University Hospital, Izumo; Masahiko Oguchi and Kyoko Ueda, Cancer Institute Hospital of the Japanese Foundation for Cancer Research; Yukio Kobayashi and Jun Itami, National Cancer Center Hospital; Bungo Saito, Showa University School of Medicine, Tokyo; Naoko Asano, Nagano Prefectural Suzaka Hospital, Suzaka; Jun Amaki and Takeshi Akiba, Tokai University School of Medicine, Isehara; Takeshi Maeda and Satoshi Itasaka, Kurashiki Central Hospital, Kurashiki; Nobuko Kubota and Yoshihiro Saito, Saitama Cancer Center, Ina; Naoto Tomita, Yokohama City University Graduate School of Medicine, Yokohama; Nodoka Sekiguchi, Shinshu University School of Medicine, Matsumoto; Jun Takizawa, Niigata University Faculty of Medicine, Niigata; Tohru Murayama, Hyogo Cancer Center, Akashi; Toshihiko Ando, Saga University, Saga; Hideho Wada, Kawasaki Medical School, Kurashiki; Rie Hyo, Nagoya University Graduate School of Medicine, Nagoya; Yasuo Ejima, Kobe University, Kobe; and Masatoshi Hasegawa, Nara Medical University, Kashihara, Japan.
authors.forename: Kana
authors.initials: K
authors.lastname: Miyazaki
authors.affiliation: Motoko Yamaguchi, Kana Miyazaki, Noriko Ii, and Naoyuki Katayama, Mie University Graduate School of Medicine, Tsu; Ritsuro Suzuki, Shimane University Hospital, Izumo; Masahiko Oguchi and Kyoko Ueda, Cancer Institute Hospital of the Japanese Foundation for Cancer Research; Yukio Kobayashi and Jun Itami, National Cancer Center Hospital; Bungo Saito, Showa University School of Medicine, Tokyo; Naoko Asano, Nagano Prefectural Suzaka Hospital, Suzaka; Jun Amaki and Takeshi Akiba, Tokai University School of Medicine, Isehara; Takeshi Maeda and Satoshi Itasaka, Kurashiki Central Hospital, Kurashiki; Nobuko Kubota and Yoshihiro Saito, Saitama Cancer Center, Ina; Naoto Tomita, Yokohama City University Graduate School of Medicine, Yokohama; Nodoka Sekiguchi, Shinshu University School of Medicine, Matsumoto; Jun Takizawa, Niigata University Faculty of Medicine, Niigata; Tohru Murayama, Hyogo Cancer Center, Akashi; Toshihiko Ando, Saga University, Saga; Hideho Wada, Kawasaki Medical School, Kurashiki; Rie Hyo, Nagoya University Graduate School of Medicine, Nagoya; Yasuo Ejima, Kobe University, Kobe; and Masatoshi Hasegawa, Nara Medical University, Kashihara, Japan.
authors.forename: Noriko
authors.initials: N
authors.lastname: Ii
authors.affiliation: Motoko Yamaguchi, Kana Miyazaki, Noriko Ii, and Naoyuki Katayama, Mie University Graduate School of Medicine, Tsu; Ritsuro Suzuki, Shimane University Hospital, Izumo; Masahiko Oguchi and Kyoko Ueda, Cancer Institute Hospital of the Japanese Foundation for Cancer Research; Yukio Kobayashi and Jun Itami, National Cancer Center Hospital; Bungo Saito, Showa University School of Medicine, Tokyo; Naoko Asano, Nagano Prefectural Suzaka Hospital, Suzaka; Jun Amaki and Takeshi Akiba, Tokai University School of Medicine, Isehara; Takeshi Maeda and Satoshi Itasaka, Kurashiki Central Hospital, Kurashiki; Nobuko Kubota and Yoshihiro Saito, Saitama Cancer Center, Ina; Naoto Tomita, Yokohama City University Graduate School of Medicine, Yokohama; Nodoka Sekiguchi, Shinshu University School of Medicine, Matsumoto; Jun Takizawa, Niigata University Faculty of Medicine, Niigata; Tohru Murayama, Hyogo Cancer Center, Akashi; Toshihiko Ando, Saga University, Saga; Hideho Wada, Kawasaki Medical School, Kurashiki; Rie Hyo, Nagoya University Graduate School of Medicine, Nagoya; Yasuo Ejima, Kobe University, Kobe; and Masatoshi Hasegawa, Nara Medical University, Kashihara, Japan.
authors.forename: Naoto
authors.initials: N
authors.lastname: Tomita
authors.affiliation: Motoko Yamaguchi, Kana Miyazaki, Noriko Ii, and Naoyuki Katayama, Mie University Graduate School of Medicine, Tsu; Ritsuro Suzuki, Shimane University Hospital, Izumo; Masahiko Oguchi and Kyoko Ueda, Cancer Institute Hospital of the Japanese Foundation for Cancer Research; Yukio Kobayashi and Jun Itami, National Cancer Center Hospital; Bungo Saito, Showa University School of Medicine, Tokyo; Naoko Asano, Nagano Prefectural Suzaka Hospital, Suzaka; Jun Amaki and Takeshi Akiba, Tokai University School of Medicine, Isehara; Takeshi Maeda and Satoshi Itasaka, Kurashiki Central Hospital, Kurashiki; Nobuko Kubota and Yoshihiro Saito, Saitama Cancer Center, Ina; Naoto Tomita, Yokohama City University Graduate School of Medicine, Yokohama; Nodoka Sekiguchi, Shinshu University School of Medicine, Matsumoto; Jun Takizawa, Niigata University Faculty of Medicine, Niigata; Tohru Murayama, Hyogo Cancer Center, Akashi; Toshihiko Ando, Saga University, Saga; Hideho Wada, Kawasaki Medical School, Kurashiki; Rie Hyo, Nagoya University Graduate School of Medicine, Nagoya; Yasuo Ejima, Kobe University, Kobe; and Masatoshi Hasegawa, Nara Medical University, Kashihara, Japan.
authors.forename: Nodoka
authors.initials: N
authors.lastname: Sekiguchi
authors.affiliation: Motoko Yamaguchi, Kana Miyazaki, Noriko Ii, and Naoyuki Katayama, Mie University Graduate School of Medicine, Tsu; Ritsuro Suzuki, Shimane University Hospital, Izumo; Masahiko Oguchi and Kyoko Ueda, Cancer Institute Hospital of the Japanese Foundation for Cancer Research; Yukio Kobayashi and Jun Itami, National Cancer Center Hospital; Bungo Saito, Showa University School of Medicine, Tokyo; Naoko Asano, Nagano Prefectural Suzaka Hospital, Suzaka; Jun Amaki and Takeshi Akiba, Tokai University School of Medicine, Isehara; Takeshi Maeda and Satoshi Itasaka, Kurashiki Central Hospital, Kurashiki; Nobuko Kubota and Yoshihiro Saito, Saitama Cancer Center, Ina; Naoto Tomita, Yokohama City University Graduate School of Medicine, Yokohama; Nodoka Sekiguchi, Shinshu University School of Medicine, Matsumoto; Jun Takizawa, Niigata University Faculty of Medicine, Niigata; Tohru Murayama, Hyogo Cancer Center, Akashi; Toshihiko Ando, Saga University, Saga; Hideho Wada, Kawasaki Medical School, Kurashiki; Rie Hyo, Nagoya University Graduate School of Medicine, Nagoya; Yasuo Ejima, Kobe University, Kobe; and Masatoshi Hasegawa, Nara Medical University, Kashihara, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Takizawa
authors.affiliation: Motoko Yamaguchi, Kana Miyazaki, Noriko Ii, and Naoyuki Katayama, Mie University Graduate School of Medicine, Tsu; Ritsuro Suzuki, Shimane University Hospital, Izumo; Masahiko Oguchi and Kyoko Ueda, Cancer Institute Hospital of the Japanese Foundation for Cancer Research; Yukio Kobayashi and Jun Itami, National Cancer Center Hospital; Bungo Saito, Showa University School of Medicine, Tokyo; Naoko Asano, Nagano Prefectural Suzaka Hospital, Suzaka; Jun Amaki and Takeshi Akiba, Tokai University School of Medicine, Isehara; Takeshi Maeda and Satoshi Itasaka, Kurashiki Central Hospital, Kurashiki; Nobuko Kubota and Yoshihiro Saito, Saitama Cancer Center, Ina; Naoto Tomita, Yokohama City University Graduate School of Medicine, Yokohama; Nodoka Sekiguchi, Shinshu University School of Medicine, Matsumoto; Jun Takizawa, Niigata University Faculty of Medicine, Niigata; Tohru Murayama, Hyogo Cancer Center, Akashi; Toshihiko Ando, Saga University, Saga; Hideho Wada, Kawasaki Medical School, Kurashiki; Rie Hyo, Nagoya University Graduate School of Medicine, Nagoya; Yasuo Ejima, Kobe University, Kobe; and Masatoshi Hasegawa, Nara Medical University, Kashihara, Japan.
authors.forename: Bungo
authors.initials: B
authors.lastname: Saito
authors.affiliation: Motoko Yamaguchi, Kana Miyazaki, Noriko Ii, and Naoyuki Katayama, Mie University Graduate School of Medicine, Tsu; Ritsuro Suzuki, Shimane University Hospital, Izumo; Masahiko Oguchi and Kyoko Ueda, Cancer Institute Hospital of the Japanese Foundation for Cancer Research; Yukio Kobayashi and Jun Itami, National Cancer Center Hospital; Bungo Saito, Showa University School of Medicine, Tokyo; Naoko Asano, Nagano Prefectural Suzaka Hospital, Suzaka; Jun Amaki and Takeshi Akiba, Tokai University School of Medicine, Isehara; Takeshi Maeda and Satoshi Itasaka, Kurashiki Central Hospital, Kurashiki; Nobuko Kubota and Yoshihiro Saito, Saitama Cancer Center, Ina; Naoto Tomita, Yokohama City University Graduate School of Medicine, Yokohama; Nodoka Sekiguchi, Shinshu University School of Medicine, Matsumoto; Jun Takizawa, Niigata University Faculty of Medicine, Niigata; Tohru Murayama, Hyogo Cancer Center, Akashi; Toshihiko Ando, Saga University, Saga; Hideho Wada, Kawasaki Medical School, Kurashiki; Rie Hyo, Nagoya University Graduate School of Medicine, Nagoya; Yasuo Ejima, Kobe University, Kobe; and Masatoshi Hasegawa, Nara Medical University, Kashihara, Japan.
authors.forename: Tohru
authors.initials: T
authors.lastname: Murayama
authors.affiliation: Motoko Yamaguchi, Kana Miyazaki, Noriko Ii, and Naoyuki Katayama, Mie University Graduate School of Medicine, Tsu; Ritsuro Suzuki, Shimane University Hospital, Izumo; Masahiko Oguchi and Kyoko Ueda, Cancer Institute Hospital of the Japanese Foundation for Cancer Research; Yukio Kobayashi and Jun Itami, National Cancer Center Hospital; Bungo Saito, Showa University School of Medicine, Tokyo; Naoko Asano, Nagano Prefectural Suzaka Hospital, Suzaka; Jun Amaki and Takeshi Akiba, Tokai University School of Medicine, Isehara; Takeshi Maeda and Satoshi Itasaka, Kurashiki Central Hospital, Kurashiki; Nobuko Kubota and Yoshihiro Saito, Saitama Cancer Center, Ina; Naoto Tomita, Yokohama City University Graduate School of Medicine, Yokohama; Nodoka Sekiguchi, Shinshu University School of Medicine, Matsumoto; Jun Takizawa, Niigata University Faculty of Medicine, Niigata; Tohru Murayama, Hyogo Cancer Center, Akashi; Toshihiko Ando, Saga University, Saga; Hideho Wada, Kawasaki Medical School, Kurashiki; Rie Hyo, Nagoya University Graduate School of Medicine, Nagoya; Yasuo Ejima, Kobe University, Kobe; and Masatoshi Hasegawa, Nara Medical University, Kashihara, Japan.
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Ando
authors.affiliation: Motoko Yamaguchi, Kana Miyazaki, Noriko Ii, and Naoyuki Katayama, Mie University Graduate School of Medicine, Tsu; Ritsuro Suzuki, Shimane University Hospital, Izumo; Masahiko Oguchi and Kyoko Ueda, Cancer Institute Hospital of the Japanese Foundation for Cancer Research; Yukio Kobayashi and Jun Itami, National Cancer Center Hospital; Bungo Saito, Showa University School of Medicine, Tokyo; Naoko Asano, Nagano Prefectural Suzaka Hospital, Suzaka; Jun Amaki and Takeshi Akiba, Tokai University School of Medicine, Isehara; Takeshi Maeda and Satoshi Itasaka, Kurashiki Central Hospital, Kurashiki; Nobuko Kubota and Yoshihiro Saito, Saitama Cancer Center, Ina; Naoto Tomita, Yokohama City University Graduate School of Medicine, Yokohama; Nodoka Sekiguchi, Shinshu University School of Medicine, Matsumoto; Jun Takizawa, Niigata University Faculty of Medicine, Niigata; Tohru Murayama, Hyogo Cancer Center, Akashi; Toshihiko Ando, Saga University, Saga; Hideho Wada, Kawasaki Medical School, Kurashiki; Rie Hyo, Nagoya University Graduate School of Medicine, Nagoya; Yasuo Ejima, Kobe University, Kobe; and Masatoshi Hasegawa, Nara Medical University, Kashihara, Japan.
authors.forename: Hideho
authors.initials: H
authors.lastname: Wada
authors.affiliation: Motoko Yamaguchi, Kana Miyazaki, Noriko Ii, and Naoyuki Katayama, Mie University Graduate School of Medicine, Tsu; Ritsuro Suzuki, Shimane University Hospital, Izumo; Masahiko Oguchi and Kyoko Ueda, Cancer Institute Hospital of the Japanese Foundation for Cancer Research; Yukio Kobayashi and Jun Itami, National Cancer Center Hospital; Bungo Saito, Showa University School of Medicine, Tokyo; Naoko Asano, Nagano Prefectural Suzaka Hospital, Suzaka; Jun Amaki and Takeshi Akiba, Tokai University School of Medicine, Isehara; Takeshi Maeda and Satoshi Itasaka, Kurashiki Central Hospital, Kurashiki; Nobuko Kubota and Yoshihiro Saito, Saitama Cancer Center, Ina; Naoto Tomita, Yokohama City University Graduate School of Medicine, Yokohama; Nodoka Sekiguchi, Shinshu University School of Medicine, Matsumoto; Jun Takizawa, Niigata University Faculty of Medicine, Niigata; Tohru Murayama, Hyogo Cancer Center, Akashi; Toshihiko Ando, Saga University, Saga; Hideho Wada, Kawasaki Medical School, Kurashiki; Rie Hyo, Nagoya University Graduate School of Medicine, Nagoya; Yasuo Ejima, Kobe University, Kobe; and Masatoshi Hasegawa, Nara Medical University, Kashihara, Japan.
authors.forename: Rie
authors.initials: R
authors.lastname: Hyo
authors.affiliation: Motoko Yamaguchi, Kana Miyazaki, Noriko Ii, and Naoyuki Katayama, Mie University Graduate School of Medicine, Tsu; Ritsuro Suzuki, Shimane University Hospital, Izumo; Masahiko Oguchi and Kyoko Ueda, Cancer Institute Hospital of the Japanese Foundation for Cancer Research; Yukio Kobayashi and Jun Itami, National Cancer Center Hospital; Bungo Saito, Showa University School of Medicine, Tokyo; Naoko Asano, Nagano Prefectural Suzaka Hospital, Suzaka; Jun Amaki and Takeshi Akiba, Tokai University School of Medicine, Isehara; Takeshi Maeda and Satoshi Itasaka, Kurashiki Central Hospital, Kurashiki; Nobuko Kubota and Yoshihiro Saito, Saitama Cancer Center, Ina; Naoto Tomita, Yokohama City University Graduate School of Medicine, Yokohama; Nodoka Sekiguchi, Shinshu University School of Medicine, Matsumoto; Jun Takizawa, Niigata University Faculty of Medicine, Niigata; Tohru Murayama, Hyogo Cancer Center, Akashi; Toshihiko Ando, Saga University, Saga; Hideho Wada, Kawasaki Medical School, Kurashiki; Rie Hyo, Nagoya University Graduate School of Medicine, Nagoya; Yasuo Ejima, Kobe University, Kobe; and Masatoshi Hasegawa, Nara Medical University, Kashihara, Japan.
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Ejima
authors.affiliation: Motoko Yamaguchi, Kana Miyazaki, Noriko Ii, and Naoyuki Katayama, Mie University Graduate School of Medicine, Tsu; Ritsuro Suzuki, Shimane University Hospital, Izumo; Masahiko Oguchi and Kyoko Ueda, Cancer Institute Hospital of the Japanese Foundation for Cancer Research; Yukio Kobayashi and Jun Itami, National Cancer Center Hospital; Bungo Saito, Showa University School of Medicine, Tokyo; Naoko Asano, Nagano Prefectural Suzaka Hospital, Suzaka; Jun Amaki and Takeshi Akiba, Tokai University School of Medicine, Isehara; Takeshi Maeda and Satoshi Itasaka, Kurashiki Central Hospital, Kurashiki; Nobuko Kubota and Yoshihiro Saito, Saitama Cancer Center, Ina; Naoto Tomita, Yokohama City University Graduate School of Medicine, Yokohama; Nodoka Sekiguchi, Shinshu University School of Medicine, Matsumoto; Jun Takizawa, Niigata University Faculty of Medicine, Niigata; Tohru Murayama, Hyogo Cancer Center, Akashi; Toshihiko Ando, Saga University, Saga; Hideho Wada, Kawasaki Medical School, Kurashiki; Rie Hyo, Nagoya University Graduate School of Medicine, Nagoya; Yasuo Ejima, Kobe University, Kobe; and Masatoshi Hasegawa, Nara Medical University, Kashihara, Japan.
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Hasegawa
authors.affiliation: Motoko Yamaguchi, Kana Miyazaki, Noriko Ii, and Naoyuki Katayama, Mie University Graduate School of Medicine, Tsu; Ritsuro Suzuki, Shimane University Hospital, Izumo; Masahiko Oguchi and Kyoko Ueda, Cancer Institute Hospital of the Japanese Foundation for Cancer Research; Yukio Kobayashi and Jun Itami, National Cancer Center Hospital; Bungo Saito, Showa University School of Medicine, Tokyo; Naoko Asano, Nagano Prefectural Suzaka Hospital, Suzaka; Jun Amaki and Takeshi Akiba, Tokai University School of Medicine, Isehara; Takeshi Maeda and Satoshi Itasaka, Kurashiki Central Hospital, Kurashiki; Nobuko Kubota and Yoshihiro Saito, Saitama Cancer Center, Ina; Naoto Tomita, Yokohama City University Graduate School of Medicine, Yokohama; Nodoka Sekiguchi, Shinshu University School of Medicine, Matsumoto; Jun Takizawa, Niigata University Faculty of Medicine, Niigata; Tohru Murayama, Hyogo Cancer Center, Akashi; Toshihiko Ando, Saga University, Saga; Hideho Wada, Kawasaki Medical School, Kurashiki; Rie Hyo, Nagoya University Graduate School of Medicine, Nagoya; Yasuo Ejima, Kobe University, Kobe; and Masatoshi Hasegawa, Nara Medical University, Kashihara, Japan.
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Katayama
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D001215:Asparaginase / Q000008:administration & dosage; D016190:Carboplatin / Q000008:administration & dosage; D059248:Chemoradiotherapy / Q000009:adverse effects; D003907:Dexamethasone / Q000009:adverse effects; D018572:Disease-Free Survival; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D007564:Japan; D054391:Lymphoma, Extranodal NK-T-Cell / Q000097:blood / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011878:Radiotherapy / Q000009:adverse effects; D015375:Receptors, Interleukin-2 / Q000097:blood; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D015375:Receptors, Interleukin-2; D005047:Etoposide; D003907:Dexamethasone; D016190:Carboplatin; D001215:Asparaginase; D007069:Ifosfamide