title: Triterpenoids with Antiplatelet Aggregation Activity from the Roots of Ilex pubescens.
abstract: Two new triterpenes and five new triterpene saponins, named ilexpusons A-G (1-7), as well as eight known compounds were isolated fromIlex pubescens. The structures of the new compounds were established by a combination of chemical and spectroscopic methods, including HRESIMS,1H-NMR,13C-NMR,1H-1H COSY, HSQC, HMBC, and NOESY. Additionally, the biological activity of compounds1-15against adenosine diphosphate-induced platelet aggregation in rabbit plasma was determined. Among the tested compounds,1, 2, 5, 6, 8, 13, 14, and15exhibited significant inhibition of platelet aggregationin vitro.
authors.affiliation: School of Chinese Materia medica, Guangzhou University of Chinese Medicine, Guangzhou, China.|Second affiliation hospital, Guangzhou University of Chinese Medicine, Guangzhou, China.
authors.forename: Qinglong
authors.initials: Q
authors.lastname: Tan
authors.affiliation: School of Chinese Materia medica, Guangzhou University of Chinese Medicine, Guangzhou, China.
authors.forename: Maosong
authors.initials: M
authors.lastname: Qiu
authors.affiliation: School of Chinese Materia medica, Guangzhou University of Chinese Medicine, Guangzhou, China.
authors.forename: Di
authors.initials: D
authors.lastname: Cao
authors.affiliation: School of Chinese Materia medica, Guangzhou University of Chinese Medicine, Guangzhou, China.
authors.forename: Tianqin
authors.initials: T
authors.lastname: Xiong
authors.affiliation: School of Chinese Materia medica, Guangzhou University of Chinese Medicine, Guangzhou, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: School of Chinese Materia medica, Guangzhou University of Chinese Medicine, Guangzhou, China.
authors.forename: Lian
authors.initials: L
authors.lastname: Zhou
authors.affiliation: School of Chinese Materia medica, Guangzhou University of Chinese Medicine, Guangzhou, China.
authors.forename: Li
authors.initials: L
authors.lastname: Rong
authors.affiliation: School of Chinese Materia medica, Guangzhou University of Chinese Medicine, Guangzhou, China.
authors.forename: Jinsong
authors.initials: J
authors.lastname: Zhou
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Jin
authors.affiliation: School of Chinese Materia medica, Guangzhou University of Chinese Medicine, Guangzhou, China.
authors.forename: Zhongxiang
authors.initials: Z
authors.lastname: Zhao
mesh_terms: D000818:Animals; D002681:China; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D030017:Ilex / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011817:Rabbits; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D004365:Drugs, Chinese Herbal; D010975:Platelet Aggregation Inhibitors; D014315:Triterpenes