title: Suspected immune-mediated neutropenia and corticosteroid responsive pancytopenia in a Portuguese water dog.
abstract: An 8-year-old spayed Portuguese water dog was presented with dysuria, lethargy, and anorexia. A profound neutropenia and pancytopenia were identified. Bone marrow aspirates revealed neutrophilic hyperplasia, a significant left shift, and toxic changes, suggesting immune-mediated destruction as a likely underlying mechanism. Immunosuppressive therapy was instituted and clinical signs improved.
authors.affiliation: Ontario Veterinary College, University of Guelph, 50 Stone Road East Guelph, Ontario N1G 2W1.
authors.forename: Ellen B
authors.initials: EB
authors.lastname: Denstedt
mesh_terms: D000818:Animals; D003907:Dexamethasone / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy / Q000276:immunology*; D004285:Dogs; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D009503:Neutropenia / Q000188:drug therapy / Q000662:veterinary*; D010198:Pancytopenia / Q000188:drug therapy / Q000662:veterinary*; D011241:Prednisone / Q000627:therapeutic use*
chemical_list: D005938:Glucocorticoids; D003907:Dexamethasone; D011241:Prednisone