title: Expression of maspin in invasive fungal rhinosinusitis.
abstract: OBJECTIVE
  This study aimed to test the expression of maspin in invasive fungal rhinosinusitis and explore its value in diagnosing invasive fungal rhinosinusitis.
  
  
  METHODS
  Forty-two fungal rhinosinusitis cases (12 invasive and 30 non-invasive) were selected as the experimental group, and 30 chronic rhinosinusitis cases comprised the control group. Maspin expression was assessed in nasal mucous membrane specimens by immunohistochemical staining.
  
  
  RESULTS
  Compared with the control group, maspin expression was down-regulated in the fungal rhinosinusitis group (p < 0.05). Furthermore, the staining score for maspin was lowest in the invasive fungal rhinosinusitis group, as compared with both the non-invasive fungal rhinosinusitis group and the control group (p < 0.05). A maspin staining score of 5.70 was the critical value for diagnosis of invasive fungal rhinosinusitis, with sensitivity and specificity of 91.7 per cent and 88.3 per cent, respectively.
  
  
  CONCLUSIONS
  The results of this study suggest that the maspin staining score may be a biomarker for effective and rapid diagnosis of invasive fungal rhinosinusitis.
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery,PLA 118 Hospital,Wenzhou,Zhejiang Province.
authors.forename: Y D
authors.initials: YD
authors.lastname: Huang
authors.affiliation: ENT Department,Huzhou Central Hospital,Zhejiang Province.
authors.forename: H W
authors.initials: HW
authors.lastname: Yu
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery,PLA 118 Hospital,Wenzhou,Zhejiang Province.
authors.forename: S W
authors.initials: SW
authors.lastname: Xia
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery,PLA 118 Hospital,Wenzhou,Zhejiang Province.
authors.forename: Z H
authors.initials: ZH
authors.lastname: Kang
authors.affiliation: ENT Department,Huzhou Central Hospital,Zhejiang Province.
authors.forename: Y S
authors.initials: YS
authors.lastname: He
authors.affiliation: ENT Institute,PLA General Hospital,Beijing,China.
authors.forename: D Y
authors.initials: DY
authors.lastname: Han
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D000072742:Invasive Fungal Infections / Q000175:diagnosis / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000378:metabolism; D009297:Nasal Mucosa / Q000378:metabolism*; D012220:Rhinitis / Q000175:diagnosis / Q000378:metabolism*; D012680:Sensitivity and Specificity; D015843:Serpins / Q000378:metabolism*; D012852:Sinusitis / Q000175:diagnosis / Q000378:metabolism*; D055815:Young Adult
chemical_list: C085344:SERPIN-B5; D015843:Serpins
keywords: Immunohistochemistry; Invasive Fungal Infection; Maspin; Mycoses; Sinusitis