title: Capsaicin and capsiate could be appropriate agents for treatment of obesity: A meta-analysis of human studies.
abstract: Consumption of capsaicin or its nonpungent analogues, capsinoids has been reported to affect energy expenditure and fat oxidation, although available data are still controversial. The aim of the present study was to conduct a meta-analysis regarding the effects of these substances on energy expenditure and respiratory quotient, with special emphasis on the role of body mass index (BMI) of the participants. Medical databases were systematically searched for papers. Of the 627 trials identified, 9 provided results suitable to be included in analysis. Data analysis showed that after ingestion of capsaicin or capsinoids the energy expenditure increased (245 kJ/day, 58.56 kcal/day, p = 0.030) and the respiratory quotient decreased (by 0.216; p = 0.031) indicating a rise in fat oxidation. Studies with mean BMI of the participants below 25 kg/m2failed to report any effect of capsaicin or capsinoids on the energy expenditure (p = 0.718) or on the respiratory quotient (p = 0.444), but studies with mean BMI exceeding 25 kg/m2demonstrated an increase in energy expenditure (292 kJ/day, 69.79 kcal/day, p = 0.023) and a marked decrease in respiratory quotient (-0.257, p = 0.036). Our data clearly suggest that capsaicin or capsiate could be a new therapeutic approach in obesity promoting a negative energy balance and increased fat oxidation.
authors.affiliation: a Institute for Translational Medicine, Medical School , University of Pécs , Pécs , Hungary.
authors.forename: Csaba
authors.initials: C
authors.lastname: Zsiborás
authors.affiliation: a Institute for Translational Medicine, Medical School , University of Pécs , Pécs , Hungary.
authors.forename: Róbert
authors.initials: R
authors.lastname: Mátics
authors.affiliation: a Institute for Translational Medicine, Medical School , University of Pécs , Pécs , Hungary.|b Hungarian Academy of Sciences - University of Szeged, Momentum Gastroenterology Multidisciplinary Research Group , Szeged , Hungary.|c Department of Translational Medicine, First Department of Medicine , University of Pécs , Pécs , Hungary.
authors.forename: Péter
authors.initials: P
authors.lastname: Hegyi
authors.affiliation: a Institute for Translational Medicine, Medical School , University of Pécs , Pécs , Hungary.
authors.forename: Márta
authors.initials: M
authors.lastname: Balaskó
authors.affiliation: a Institute for Translational Medicine, Medical School , University of Pécs , Pécs , Hungary.
authors.forename: Erika
authors.initials: E
authors.lastname: Pétervári
authors.affiliation: d Department of Gastroenterology, First Department of Medicine , University of Pécs , Pécs , Hungary.
authors.forename: Imre
authors.initials: I
authors.lastname: Szabó
authors.affiliation: c Department of Translational Medicine, First Department of Medicine , University of Pécs , Pécs , Hungary.
authors.forename: Patrícia
authors.initials: P
authors.lastname: Sarlós
authors.affiliation: a Institute for Translational Medicine, Medical School , University of Pécs , Pécs , Hungary.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Mikó
authors.affiliation: a Institute for Translational Medicine, Medical School , University of Pécs , Pécs , Hungary.
authors.forename: Judit
authors.initials: J
authors.lastname: Tenk
authors.affiliation: a Institute for Translational Medicine, Medical School , University of Pécs , Pécs , Hungary.
authors.forename: Ildikó
authors.initials: I
authors.lastname: Rostás
authors.affiliation: a Institute for Translational Medicine, Medical School , University of Pécs , Pécs , Hungary.
authors.forename: Dániel
authors.initials: D
authors.lastname: Pécsi
authors.affiliation: a Institute for Translational Medicine, Medical School , University of Pécs , Pécs , Hungary.
authors.forename: András
authors.identifier: http://orcid.org/0000-0003-2493-0571
authors.initials: A
authors.lastname: Garami
authors.affiliation: a Institute for Translational Medicine, Medical School , University of Pécs , Pécs , Hungary.
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Rumbus
authors.affiliation: e First Department of Surgery , Semmelweis University , Budapest , Hungary.
authors.forename: Orsolya
authors.initials: O
authors.lastname: Huszár
authors.affiliation: a Institute for Translational Medicine, Medical School , University of Pécs , Pécs , Hungary.
authors.forename: Margit
authors.initials: M
authors.lastname: Solymár
mesh_terms: D015992:Body Mass Index; D002211:Capsaicin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004734:Energy Metabolism / Q000187:drug effects; D006801:Humans; D050356:Lipid Metabolism / Q000187:drug effects; D009765:Obesity / Q000188:drug therapy*; D016032:Randomized Controlled Trials as Topic; D056152:Respiratory Rate / Q000187:drug effects
chemical_list: C470213:capsiate; D002211:Capsaicin
keywords: Capsaicinoid; energy expenditure; fat oxidation; metabolic rate; obesity management