title: Bisphenol A and Ovarian Reserve among Infertile Women with Polycystic Ovarian Syndrome.
abstract: To better understand possible effects of bisphenol A (BPA) exposure on ovarian reserve in women with polycystic ovary syndrome (PCOS), we measured creatinine adjusted urinary BPA (BPA_Cre) concentrations and used regression models to evaluate the association between urinary BPA level and antral follicle count (AFC), antimullerian hormone (AMH), day-3 follicle stimulating hormone levels (FSH) and inhibin B (INHB) in 268 infertile women diagnosed with PCOS. BPA was detected in all women with a median concentration of 2.35 ng/mL (the 25th and 75th percentiles of 1.47 ng/mL and 3.95 ng/mL). A unit increase in BPA_Cre was associated with a significant decrease of 0.34 in AFC (β = -0.34, 95% CI = -0.60, -0.08;p= 0.01). Likewise, BPA was negatively associated with AMH and day-3 FSH levels, but neither of them reached statistical significance. No association was observed between BPA and INHB. Our results suggest that in women with PCOS, BPA may affect ovarian follicles and, therefore, reduce ovarian reserve.
authors.affiliation: Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, School of Medicine, Shanghai Jiao-Tong University, Shanghai 200092, China. zzsmile12@163.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhou
authors.affiliation: Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, School of Medicine, Shanghai Jiao-Tong University, Shanghai 200092, China. fangfang19881106@163.com.
authors.forename: Fang
authors.initials: F
authors.lastname: Fang
authors.affiliation: Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, School of Medicine, Shanghai Jiao-Tong University, Shanghai 200092, China. windy5490@163.com.
authors.forename: Wenting
authors.initials: W
authors.lastname: Zhu
authors.affiliation: Center for Reproductive Medicine, Shandong Provincial Hospital, Shandong University, Shandong 250100, China. chenzijiang@vip.163.com.|Ministry of Education-The Key Laboratory of Reproductive Endocrinology, Shandong University, Shandong 250100, China. chenzijiang@vip.163.com.|Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China. chenzijiang@vip.163.com.|Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai 200092, China. chenzijiang@vip.163.com.
authors.forename: Zi-Jiang
authors.initials: ZJ
authors.lastname: Chen
authors.affiliation: Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China. yanzhidu@hotmail.com.|Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai 200092, China. yanzhidu@hotmail.com.
authors.forename: Yanzhi
authors.initials: Y
authors.lastname: Du
authors.affiliation: Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, School of Medicine, Shanghai Jiao-Tong University, Shanghai 200092, China. junjimzhang@sina.com.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000652:urine; D001559:Benzhydryl Compounds / Q000009:adverse effects* / Q000652:urine; D015415:Biomarkers / Q000652:urine; D002681:China; D003430:Cross-Sectional Studies; D052244:Endocrine Disruptors / Q000009:adverse effects* / Q000652:urine; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000150:complications* / Q000503:physiopathology* / Q000652:urine; D006080:Ovarian Follicle / Q000187:drug effects; D065851:Ovarian Reserve / Q000187:drug effects*; D010636:Phenols / Q000009:adverse effects* / Q000652:urine; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000652:urine; D000098826:Bisphenol A Compounds
chemical_list: D054304:Anti-Mullerian Hormone; D001559:Benzhydryl Compounds; D015415:Biomarkers; D052244:Endocrine Disruptors; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: antimullerian hormone; antral follicle count; bisphenol A; day-3 follicle stimulating hormone; ovarian reserve