title: Gogadget: An R Package for Interpretation and Visualization of GO Enrichment Results.
abstract: Gene expression profiling followed by gene ontology (GO) term enrichment analysis can generate long lists of significant GO terms. To interpret these results and get biological insight in the data, filtering and rearranging these long lists of GO terms might be desirable. The R package gogadget provides functions to modify GO analysis results, with a simple filter strategy. Furthermore, it groups redundant GO terms with hierarchical clustering and presents the results in a colorful heatmap. The filtered GO term enrichment results can also be exported by the package for subsequent analysis in Cytoscape Enrichment Map. The R package is freely available under the terms of the GNU GPLv3 at https://sourceforge.net/projects/gogadget/.
authors.affiliation: Department of Research Facilities, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Nota
mesh_terms: D016000:Cluster Analysis; D019295:Computational Biology / Q000379:methods; D020869:Gene Expression Profiling / Q000379:methods; D063990:Gene Ontology; D017422:Sequence Analysis, DNA / Q000379:methods*; D012984:Software
keywords: GO; Gene ontology; RNA-Seq; gene expression