title: Three simultaneous cases of hypersensitivity pneumonitis and acute lung injury caused by dichloromethane.
abstract: Three middle-aged male patients were admitted to our hospital complaining of dry cough, dyspnoea, and fever. All three of them had cleaned a refrigerator at a Chinese noodle mill using paint remover containing dichloromethane (90%) the previous day. Chest X-rays revealed bilateral diffuse infiltrative shadows on the lungs. We performed transbronchial lung biopsies and bronchoalveolar lavage (BAL) via bronchoscopy for each patient. Bronchoalveolar lavage showed increased total cell count as well as lymphocyte and neutrophil fraction. Transbronchial lung biopsy revealed Masson bodies and slight lymphocyte infiltration into the alveolar septa. We diagnosed all three patients with hypersensitivity pneumonitis and acute lung injury caused by exposure to the paint remover containing dichloromethane. Two of these patients ultimately went into respiratory failure, requiring the administration of a corticosteroid. The third patient improved without the need of steroid therapy.
authors.affiliation: First Department of Medicine Obihiro Kosei General Hospital Obihiro Japan.
authors.forename: Kei
authors.initials: K
authors.lastname: Takamura
authors.affiliation: First Department of Medicine Obihiro Kosei General Hospital Obihiro Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Ogi
authors.affiliation: First Department of Medicine Obihiro Kosei General Hospital Obihiro Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Yamamoto
authors.affiliation: Department of Pathology Obihiro Kosei General Hospital Obihiro Japan.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Kikuchi
keywords: Acute lung injury; dichloromethane; hypersensitivity pneumonitis; simultaneous occurrence