title: Serum lipids modify periodontal infection - interleukin-6 association.
abstract: The aim of this study was to investigate whether the systemic response against a local inflammatory process in periodontium is dependent on the individual's serum lipid composition.
  
  
  
  This study was based on a subpopulation of the Health 2000 Survey that included 878 subjects who were aged between 45 and 64 years, dentate, non-diabetic and non-rheumatic. The inflammatory condition of periodontium was measured by means of the number of teeth with deepened (4 mm or deeper) periodontal pockets. Systemic inflammation was assessed by means of the serum levels of interleukin-6 (IL-6) and tumour necrosis factor alpha (TNF-α). The association between an inflammatory condition in the periodontium and the systemic inflammatory response was analysed using linear regression models.
  
  
  
  The number of teeth with deepened periodontal pockets was associated with elevated serum IL-6 levels among subjects with an unfavourable lipid composition (low-density lipoprotein cholesterol ≥3.7 mmol/l or high-density lipoprotein cholesterol <1.3 mmol/l). There was no association between serum TNF-α levels and the number of teeth with deepened periodontal pockets in these data.
  
  
  
  The systemic response against the inflammatory condition of periodontium varied between individuals. The variation appeared to be dependent on the serum lipid composition or related factors.
authors.affiliation: Institute of Dentistry, University of Eastern Finland, Kuopio, Finland.|City of Äänekoski, Public Health Centre, Oral Health Care Services, Äänekoski, Finland.
authors.forename: Anniina
authors.initials: A
authors.lastname: Haro
authors.affiliation: Institute of Dentistry, University of Eastern Finland, Kuopio, Finland.|Department of Oral and Maxillofacial Surgery, Kuopio University Hospital, Kuopio, Finland.|Institute of Dentistry, University of Oulu, Oulu, Finland.
authors.forename: Tuomas
authors.initials: T
authors.lastname: Saxlin
authors.affiliation: Institute of Dentistry, University of Eastern Finland, Kuopio, Finland.|Department of Oral and Maxillofacial Surgery, Kuopio University Hospital, Kuopio, Finland.|The Living Environment and Health Unit, National Institute for Health and Welfare, Kuopio, Finland.|The Health Monitoring Unit, National Institute for Health and Welfare, Helsinki, Finland.
authors.forename: Anna Liisa
authors.identifier: 0000-0002-8543-0055
authors.initials: AL
authors.lastname: Suominen
authors.affiliation: National Institute for Health and Welfare (THL), Turku, Finland.
authors.forename: Antti
authors.initials: A
authors.lastname: Jula
authors.affiliation: Institute of Dentistry, University of Oulu, Oulu, Finland.|Unit of Oral Health Sciences, Medical Research Center Oulu (MRC Oulu), Oulu University Hospital and Oulu University, Oulu, Finland.
authors.forename: Matti
authors.initials: M
authors.lastname: Knuuttila
authors.affiliation: Institute of Dentistry, University of Eastern Finland, Kuopio, Finland.|Department of Oral and Maxillofacial Surgery, Kuopio University Hospital, Kuopio, Finland.|Unit of Oral Health Sciences, Medical Research Center Oulu (MRC Oulu), Oulu University Hospital and Oulu University, Oulu, Finland.
authors.forename: Pekka
authors.initials: P
authors.lastname: Ylöstalo
mesh_terms: D000368:Aged; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000097:blood* / Q000382:microbiology; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha
keywords: interleukin-6; lipids; lipoproteins; periodontitis; tumour necrosis factor alpha