title: Influence of vitamin D signaling on hormone receptor status and HER2 expression in breast cancer.
abstract: OBJECTIVE
  Breast cancer is a significant global public health issue. It is the leading cause of death among women around the world, with an incidence increasing annually. In recent years, there has been more and more information in the literature regarding a protective role of vitamin D in cancer. Increasingly preclinical and clinical studies suggest that vitamin D optimal levels can reduce the risk of breast cancer development and regulate cancer-related pathways.
  
  
  METHODS
  In this review, we focus on the importance of vitamin D in breast cancers, discussing especially the influence of vitamin D signaling on estrogen receptor and human epidermal growth factor receptor 2 (HER2), two major biomarkers of breast cancer today.
  
  
  CONCLUSIONS
  We discuss the possibility of actual and future targeted therapeutic approaches for vitamin D signaling in breast cancer.
authors.affiliation: Brustzentrum der Universität München, Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Campus Innenstadt, Klinikum der Ludwig-Maximilians-Universität, Maistraße 11, 80337, Munich, Germany.
authors.forename: Xi
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Brustzentrum der Universität München, Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Campus Innenstadt, Klinikum der Ludwig-Maximilians-Universität, Maistraße 11, 80337, Munich, Germany.
authors.forename: Nadia
authors.initials: N
authors.lastname: Harbeck
authors.affiliation: Brustzentrum der Universität München, Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Campus Innenstadt, Klinikum der Ludwig-Maximilians-Universität, Maistraße 11, 80337, Munich, Germany.
authors.forename: Udo
authors.initials: U
authors.lastname: Jeschke
authors.affiliation: Brustzentrum der Universität München, Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Campus Innenstadt, Klinikum der Ludwig-Maximilians-Universität, Maistraße 11, 80337, Munich, Germany. sophie.doisneausixou@med.lmu.de.|Faculté des Sciences Pharmaceutiques, Université Paul Sabatier Toulouse III, 31062, Toulouse Cedex 09, France. sophie.doisneausixou@med.lmu.de.
authors.forename: Sophie
authors.initials: S
authors.lastname: Doisneau-Sixou
mesh_terms: D001943:Breast Neoplasms / Q000378:metabolism*; D005260:Female; D006801:Humans; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000096:biosynthesis*; D011960:Receptors, Estrogen / Q000096:biosynthesis*; D011980:Receptors, Progesterone / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D014807:Vitamin D / Q000378:metabolism*
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D014807:Vitamin D; C508053:ERBB2 protein, human
keywords: Breast cancer; Estrogen receptor; HER2; Vitamin D; Vitamin D receptor