title: Light-Enhancing Plasmonic-Nanopore Biosensor for Superior Single-Molecule Detection.
abstract: A stacked plasmonic nanowell-nanopore biosensor strongly suppresses the background fluorescence from the bulk and yields net more than tenfold enhancement of the fluorescence intensity. The device offers extremely high signal-to-background (S/B) ratio for single-molecule detection at ultralow excitation laser intensities, while maintaining extremely high temporal bandwidth for single-DNA sensing.
authors.affiliation: Department of Biomedical Engineering, The Technion -Israel Institute of Technology, Haifa, 32000, Israel.|Department of Biomedical Engineering, Boston University, Boston, MA, 02215, USA.
authors.forename: Ossama N
authors.initials: ON
authors.lastname: Assad
authors.affiliation: Department of Biomedical Engineering, The Technion -Israel Institute of Technology, Haifa, 32000, Israel.
authors.forename: Tal
authors.initials: T
authors.lastname: Gilboa
authors.affiliation: Department of Biomedical Engineering, The Technion -Israel Institute of Technology, Haifa, 32000, Israel.
authors.forename: Joshua
authors.initials: J
authors.lastname: Spitzberg
authors.affiliation: Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, Aachen, 52056, Germany.
authors.forename: Matyas
authors.initials: M
authors.lastname: Juhasz
authors.affiliation: Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, Aachen, 52056, Germany.
authors.forename: Elmar
authors.initials: E
authors.lastname: Weinhold
authors.affiliation: Department of Biomedical Engineering, The Technion -Israel Institute of Technology, Haifa, 32000, Israel.|Department of Biomedical Engineering, Boston University, Boston, MA, 02215, USA.
authors.forename: Amit
authors.initials: A
authors.lastname: Meller
mesh_terms: D015374:Biosensing Techniques; D004247:DNA; D008027:Light; D058608:Nanopores; D036103:Nanotechnology
chemical_list: D004247:DNA
keywords: DNA sequencing; fluorescence enhancement; plasmonic nanostructures; single-molecule sensing; solid-state nanopores