title: Protein tyrosine phosphatase 1B inhibitors as antidiabetic agents - A brief review.
abstract: Diabetes mellitus and obesity are one of the most common health issues spread throughout world and raised the medical attention to find the new effective agents to treat these disease state. Occurrence of the drug resistance to the insulin and leptin receptor is also challenging major issues. The molecules that can overcome this resistance problem could be effective for the treatment of both type II diabetes and obesity. Protein Tyrosine Phosphatase (PTP) has emerged as new promising targets for therapeutic purpose in recent years. Protein Tyrosine Phosphatase 1B (PTP 1B) act as a negative regulator of insulin and leptin receptor signalling pathways. Several approaches have been successfully applied to find out potent and selective inhibitors. This article reviews PTP 1B inhibitors; natural, synthetic and semi-synthetic that showed inhibition towards enzyme as a major target for the management of type II diabetes. These studies could be contributing the future development of PTP 1B inhibitors as drugs.
authors.affiliation: Department of Pharmaceutical Technology, Meerut Institute of Engineering & Technology, Baghpat By-pass Crossing, NH-58, Delhi-Haridwar Highway, Meerut 250005, India. Electronic address: mansi7184@gmail.com.
authors.forename: Mansi
authors.initials: M
authors.lastname: Verma
authors.affiliation: Department of Chemistry, Indian Institute of Chemical Biology (CSIR), 4, Raja S.C. Mullick Road, Jadavpur, Kolkata 700032, W.B., India.
authors.forename: Shyam Ji
authors.initials: SJ
authors.lastname: Gupta
authors.affiliation: Department of Pharmaceutical Technology, Meerut Institute of Engineering & Technology, Baghpat By-pass Crossing, NH-58, Delhi-Haridwar Highway, Meerut 250005, India.
authors.forename: Anurag
authors.initials: A
authors.lastname: Chaudhary
authors.affiliation: Department of Pharmaceutical Technology, Meerut Institute of Engineering & Technology, Baghpat By-pass Crossing, NH-58, Delhi-Haridwar Highway, Meerut 250005, India.
authors.forename: Vipin K
authors.initials: VK
authors.lastname: Garg
mesh_terms: D000818:Animals; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000201:enzymology; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007004:Hypoglycemic Agents / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D010946:Plants, Medicinal / Q000737:chemistry; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D001688:Biological Products; D004791:Enzyme Inhibitors; D007004:Hypoglycemic Agents; C516607:PTPN1 protein, human; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1
keywords: Antidiabetic; Diabetes; Inhibitors; Insulin; PTP 1B; Phosphatase