title: Vaspin and selected indices of bone status in girls with anorexia nervosa.
abstract: BACKGROUND
  In vitro studies indicate that vaspin may act as a regulator of bone metabolism. The aim of the study was to evaluate the relationship between vaspin and bone metabolism in girls with anorexia nervosa (AN), as well as the potential involvement of OPG and RANKL in this relationship.
  
  
  METHODS
  Serum vaspin, OC, CTx, OPG, and sRANKL were determined by ELISA in 50 girls with AN and in 30 healthy controls aged 13 to 17 years.
  
  
  RESULTS
  Girls with AN exhibited significant reduction in body weight, BMI, and Cole index as well as a significant increase in serum level of vaspin compared to healthy participants. These changes were associated with a significant decrease in serum OC and CTx levels and a significant increase in OPG and sRANKL, while the OPG/sRANKL ratio was significantly decreased. BMI and Cole index correlated negatively and significantly with CTx levels in the control group (C), girls with AN, and all study participants (C+AN). Girls with AN showed a significant negative correlation between BMI, the Cole index, and OPG levels. The combination group (C+AN) showed a significant positive correlation between BMI, Cole index, and the OPG/sRANKL ratio. In this group of girls vaspin levels correlated positively and significantly with sRANKL and negatively with body weight, BMI, Cole index, and OPG/sRANKL ratio. Girls with AN showed a significant negative correlation between vaspin levels and the OPG/sRANKL ratio.
  
  
  CONCLUSIONS
  Undernourishment and associated deficit of adipose tissue may result in inadequate vaspin production and bone metabolism disorders in girls with AN. Vaspin acts as a coordinator of the dynamic balance between bone formation and resorption processes; its action is affected by the cytokines of the RANKL/RANK/OPG system. Changes in the relationships between vaspin, bone markers, OPG, and RANKL might contribute to the development of osteoporosis in girls with AN. (Endokrynol Pol 2016; 67 (6): 599-606).
authors.affiliation: Department of Medical and Molecular Biology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland. ozdrasiek@poczta.onet.pl.
authors.forename: Zofia
authors.initials: Z
authors.lastname: Ostrowska
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Ziora
authors.forename: Joanna
authors.initials: J
authors.lastname: Oświęcimska
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Świętochowska
authors.forename: Bogdan
authors.initials: B
authors.lastname: Marek
authors.forename: Dariusz
authors.initials: D
authors.lastname: Kajdaniuk
authors.forename: Joanna
authors.initials: J
authors.lastname: Strzelczyk
authors.forename: Karolina
authors.initials: K
authors.lastname: Gołąbek
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Morawiecka-Pietrzak
authors.forename: Kinga
authors.initials: K
authors.lastname: Wołkowska-Pokrywa
authors.forename: Beata
authors.initials: B
authors.lastname: Kos-Kudła
mesh_terms: D000293:Adolescent; D000856:Anorexia Nervosa / Q000097:blood / Q000378:metabolism* / Q000503:physiopathology; D016723:Bone Remodeling; D005260:Female; D006801:Humans; D053245:RANK Ligand / Q000097:blood; D015843:Serpins / Q000097:blood*
chemical_list: D053245:RANK Ligand; C507339:SERPINA12 protein, human; D015843:Serpins; C505688:TNFSF11 protein, human
keywords: OPG; OPG/sRANKL ratio; anorexia nervosa; bone metabolism; girls; sRANKL; vaspin