title: Facile synthesis of thietanes via ring expansion of thiiranes.
abstract: Thietanes are pharmaceutically important cores of some biological compounds and intermediates of organic synthesis. Various thietanes were prepared from thiiranes via ring expansion through a reaction with trimethyloxosulfonium iodide in the presence of sodium hydride. The reaction process is a nucleophilic ring-opening reaction of thiiranes with dimethyloxosulfonium methylide, generated from trimethyloxosulfonium iodide and sodium hydride, and subsequent intramolecular displacement (cyclization) of thiolates to the dimethyloxosulfonium moiety. The current method provides a new strategy for efficient preparation of thietanes from readily available thiiranes.
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Department of Organic Chemistry, Faculty of Science, Beijing University of Chemical Technology, Beijing 100029, People's Republic of China. jxxu@mail.buct.edu.cn.
authors.forename: Jun
authors.initials: J
authors.lastname: Dong
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Department of Organic Chemistry, Faculty of Science, Beijing University of Chemical Technology, Beijing 100029, People's Republic of China. jxxu@mail.buct.edu.cn.
authors.forename: Jiaxi
authors.initials: J
authors.lastname: Xu