title: Comparative evaluation of platelet-rich fibrin versus beta-tri-calcium phosphate in the treatment of Grade II mandibular furcation defects using cone-beam computed tomography.
abstract: OBJECTIVE
  The objective of the study was to evaluate clinically and radiographically the efficacy of platelet-rich fibrin (PRF) versus β-tri-calcium phosphate (β-TCP) in the treatment of Grade II mandibular furcation defects.
  
  
  METHODS
  Forty-five Grade II furcation defect in mandibular molars which were assigned to open flap debridement (OFD) with PRF Group I (n= 15), to OFD with β-TCP Group II (n= 15), and to OFD alone Group III (n= 15) were analyzed for clinical parameters (probing pocket depth [PPD], vertical clinical attachment level [VCAL], horizontal clinical attachment level [HCAL], gingival recession, relative vertical height of furcation [r-VHF], and relative horizontal depth of furcation [r-HDF]) and radiographical parameters (horizontal depth of furcation [H-DOF], vertical height of furcation [V-HOF]) using cone-beam computed tomography (CBCT) at 6 months interval.
  
  
  RESULTS
  For clinical parameters, reduction in PPD and gain in VCAL and HCAL were higher in Group II as compared to Group I. Change in r-VHF and r-HDF was greater in Group II as compared to Group I. Mean percentage clinical vertical defect fill was higher in Group II as compared to Group I (58.52% ± 11.68% vs. 53.24% ± 13.22%, respectively). On CBCT, mean change at 6 months for all parameters showed nonsignificant difference between the two experimental groups. Mean change in V-HOF was higher in Group I as compared to Group II, but mean change in H-DOF and furcation width was more in Group II as compared to Group I.
  
  
  CONCLUSIONS
  For both experimental and control groups, there was statistically significant improvement at 6 months follow-up from baseline values.
authors.affiliation: Department of Periodontology, Saraswati Dental College and Hospital, Lucknow, Uttar Pradesh, India.
authors.forename: Zeba Rahman
authors.initials: ZR
authors.lastname: Siddiqui
authors.affiliation: Department of Periodontology, Saraswati Dental College and Hospital, Lucknow, Uttar Pradesh, India.
authors.forename: Rajesh
authors.initials: R
authors.lastname: Jhingran
authors.affiliation: Department of Periodontology, Saraswati Dental College and Hospital, Lucknow, Uttar Pradesh, India.
authors.forename: Vivek Kumar
authors.initials: VK
authors.lastname: Bains
authors.affiliation: Department of Periodontology, Saraswati Dental College and Hospital, Lucknow, Uttar Pradesh, India.
authors.forename: Ruchi
authors.initials: R
authors.lastname: Srivastava
authors.affiliation: Department of Periodontology, Saraswati Dental College and Hospital, Lucknow, Uttar Pradesh, India.
authors.forename: Rohit
authors.initials: R
authors.lastname: Madan
authors.affiliation: Department of Periodontology, Saraswati Dental College and Hospital, Lucknow, Uttar Pradesh, India.
authors.forename: Iram
authors.initials: I
authors.lastname: Rizvi
keywords: Cone-beam computed tomography; Grade II furcation involvement; periodontal regeneration; platelet-rich fibrin; β-tri-calcium phosphate