title: Chemoenzymatic Dynamic Kinetic Resolution of Secondary Alcohols Using an Air- and Moisture-Stable Iron Racemization Catalyst.
abstract: Herein, we report on a metalloenzymatic dynamic kinetic resolution of sec-alcohols employing an iron-based racemization catalyst together with a lipase. The iron catalyst was evaluated in racemization and then used in dynamic kinetic resolution of a number of sec-alcohols to give enantiomerically pure products in good to high yields. The iron catalyst is air and moisture stable and is readily accessible.
authors.affiliation: Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, 10691, Stockholm, Sweden.
authors.forename: Karl P J
authors.initials: KP
authors.lastname: Gustafson
authors.affiliation: Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, 10691, Stockholm, Sweden.
authors.forename: Arnar
authors.initials: A
authors.lastname: Guðmundsson
authors.affiliation: Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, 10691, Stockholm, Sweden.
authors.forename: Kayla
authors.initials: K
authors.lastname: Lewis
authors.affiliation: Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, 10691, Stockholm, Sweden.
authors.forename: Jan-E
authors.identifier: http://orcid.org/0000-0001-8462-4176
authors.initials: JE
authors.lastname: Bäckvall
keywords: dynamic kinetic resolution; enzyme catalysis; iron catalysis; racemization; secondary alcohols