title: Imine reductases (IREDs).
abstract: Imine reductases (IREDs) have emerged as a valuable new set of biocatalysts for the asymmetric synthesis of optically active amines. The development of bioinformatics tools and searchable databases has led to the identification of a diverse range of new IRED biocatalysts that have been characterised and employed in different synthetic processes. This review describes the latest developments in the structural and mechanistic aspects of IREDs, together with synthetic applications of these enzymes, and identifies ongoing and future challenges in the field.
authors.affiliation: School of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester M1 7DN, UK.
authors.forename: Juan
authors.initials: J
authors.lastname: Mangas-Sanchez
authors.affiliation: School of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester M1 7DN, UK.
authors.forename: Scott P
authors.initials: SP
authors.lastname: France
authors.affiliation: School of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester M1 7DN, UK.
authors.forename: Sarah L
authors.initials: SL
authors.lastname: Montgomery
authors.affiliation: School of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester M1 7DN, UK.
authors.forename: Godwin A
authors.initials: GA
authors.lastname: Aleku
authors.affiliation: York Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York YO10 5DD, UK.
authors.forename: Henry
authors.initials: H
authors.lastname: Man
authors.affiliation: York Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York YO10 5DD, UK.
authors.forename: Mahima
authors.initials: M
authors.lastname: Sharma
authors.affiliation: School of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester M1 7DN, UK.
authors.forename: Jeremy I
authors.initials: JI
authors.lastname: Ramsden
authors.affiliation: York Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York YO10 5DD, UK.
authors.forename: Gideon
authors.initials: G
authors.lastname: Grogan
authors.affiliation: School of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester M1 7DN, UK. Electronic address: nicholas.turner@manchester.ac.uk.
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Turner
mesh_terms: D000586:Amination; D055162:Biocatalysis; D007097:Imines / Q000378:metabolism*; D010084:Oxidation-Reduction; D010088:Oxidoreductases / Q000737:chemistry / Q000378:metabolism*
chemical_list: D007097:Imines; D010088:Oxidoreductases