title: Sleep changes without medial temporal lobe or brain cortical changes in community-dwelling individuals with subjective cognitive decline.
abstract: BACKGROUND
  Subjective cognitive decline (SCD) is a risk factor for mild cognitive impairment (MCI) and Alzheimer's disease (AD). Although sleep has been shown to be altered in MCI and AD, little is known about sleep in SCD.
  
  
  METHODS
  Seventy cognitively normal community-dwelling participants were classified as SCD (32) or controls (38) using the Subjective Cognitive Decline Questionnaire. Sleep was assessed using actigraphy and diaries. FreeSurfer was used for performing medial temporal lobes (MTLs) and brain cortical parcellation of 3T magnetic resonance images. Multiple regression models were used to assess the presence of sleep, MTL, or regional cortical differences between groups.
  
  
  RESULTS
  Objective sleep was disrupted in SCD participants, which showed increased nighttime wakefulness and reduced sleep efficiency. No group differences emerged in subjective sleep or magnetic resonance imaging outcomes.
  
  
  CONCLUSIONS
  Objective sleep resulted disrupted in community-dwelling SCD, without any subjective sleep or cortical change. Sleep assessment/intervention in SCD might help prevent/delay AD onset.
authors.affiliation: Department of Neuroscience, Imaging and Clinical Science, University "G. d'Annunzio" of Chieti-Pescara, Chieti, Italy; Institute for Advanced Biomedical Technologies, University "G. d'Annunzio" of Chieti-Pescara, Chieti, Italy; Department of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, CA, USA. Electronic address: mariella.lauriola@gmail.com.
authors.forename: Mariella
authors.initials: M
authors.lastname: Lauriola
authors.affiliation: Department of Neuroscience, Imaging and Clinical Science, University "G. d'Annunzio" of Chieti-Pescara, Chieti, Italy; Institute for Advanced Biomedical Technologies, University "G. d'Annunzio" of Chieti-Pescara, Chieti, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Esposito
authors.affiliation: Department of Neuroscience, Imaging and Clinical Science, University "G. d'Annunzio" of Chieti-Pescara, Chieti, Italy; Institute for Advanced Biomedical Technologies, University "G. d'Annunzio" of Chieti-Pescara, Chieti, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Delli Pizzi
authors.affiliation: Center for Health Sciences, SRI International, Menlo Park, CA, USA.
authors.forename: Massimiliano
authors.initials: M
authors.lastname: de Zambotti
authors.affiliation: Azienda Sanitaria Locale di Pescara (ASL), Centro di Salute Mentale Pescara Nord, Pescara, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Londrillo
authors.affiliation: Department of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, CA, USA.
authors.forename: Joel H
authors.initials: JH
authors.lastname: Kramer
authors.affiliation: Department of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, CA, USA.
authors.forename: Gil D
authors.initials: GD
authors.lastname: Rabinovici
authors.affiliation: Department of Neuroscience, Imaging and Clinical Science, University "G. d'Annunzio" of Chieti-Pescara, Chieti, Italy; Institute for Advanced Biomedical Technologies, University "G. d'Annunzio" of Chieti-Pescara, Chieti, Italy.
authors.forename: Armando
authors.initials: A
authors.lastname: Tartaro
mesh_terms: D000368:Aged; D060825:Cognitive Dysfunction / Q000175:diagnosis* / Q000523:psychology; D005260:Female; D006801:Humans; D057187:Independent Living; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D012890:Sleep / Q000502:physiology*; D011795:Surveys and Questionnaires; D013702:Temporal Lobe / Q000473:pathology*
keywords: Actigraphy; Alzheimer's disease; MRI; Medial temporal lobe; Risk factors; Sleep; Subjective cognitive decline