title: Association of lnc-LAMC2-1:1 rs2147578 and CASC8 rs10505477 Polymorphisms with Risk of Childhood Acute Lymphoblastic Leukemia
abstract: Long non-coding RNAs (lncRNAs) are a novel class of non-protein coding RNAs that are involved in a wide variety
  of biological processes. There are limited data regarding the impact of lnc-LAMC2-1:1 rs2147578 as well as CASC8
  rs10505477 T>C polymorphisms on cancer development. Here we examined for the first time whether rs2147578
  and rs10505477 polymorphisms are associated with childhood acute lymphoblastic leukemia (ALL) in a total of 110
  cases and 120 healthy controls. Genotyping was achieved by the polymerase chain reaction-restriction fragment length
  polymorphism (PCR-RFLP) method. The rs2147578 variant increased the risk of ALL in codominant (OR=4.33,
  95%CI=2.00-9.37, p<0.0001, CG vs CC, and OR=5.81, 95%CI=2.30-14.69, p=0.0002, GG vs CC), dominant (OR=4.63,
  95%CI=2.18-9.86, p<0.0001, CG+GG vs CC), overdominant (OR=1.74, 95%CI=1.02-2.97, p=0.0444, CG vs CC+GG)
  and allele (OR=1.91, 95%CI=1.32-2.77, p=0.0008, G vs C) inheritance models tested. No significant association was
  found between the CASC8 rs10505477 T>C variant and risk of childhood ALL. In conclusion, the present study revealed
  that the lnc-LAMC2-1:1 rs2147578 polymorphism may be a risk factor for developing childhood ALL. Further studies
  with larger sample sizes with different ethnicities are now required to confirm our findings.
authors.affiliation: Cellular and Molecular Research Center, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.|Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran. Email: mhd.hashemi@gmail.com, hashemim@zaums.ac.ir
authors.forename: Mohammad
authors.initials: M
authors.lastname: Hashemi
authors.forename: Gholamreza
authors.initials: G
authors.lastname: Bahari
authors.forename: Majid
authors.initials: M
authors.lastname: Naderi
authors.forename: Simin
authors.initials: S
authors.lastname: Sadeghi Bojd
authors.forename: Mohsen
authors.initials: M
authors.lastname: Taheri
keywords: Long non-coding RNA; lnc-LAMC2-1:1; CASC8; acute lymphoblastic leukemia; Polymorphism