title: Does early onset cataract increase the risk of ischemic stroke? A nationwide retrospective cohort study.
abstract: This study was attempted to address the association between early onset cataract (EOC) and ischemic stroke. Using the Longitudinal Health Insurance Database 2000, we established an EOC cohort and a comparison cohort by using 4-fold propensity score matching according to age, gender and comorbidities to detect the incidence of ischemic stroke. A Cox model was used to express the risk of ischemic stroke for the EOC patients compared with the comparison cohort. After adjusting for age, gender and comorbidities of hypertension, diabetes mellitus, hyperlipidemia, coronary artery disease, asthma, chronic obstructive pulmonary disease, chronic kidney disease, heart failure, obesity, and atrial fibrillation, the EOC patients had a 1.48-fold higher risk of ischemic stroke than the comparison cohort, but it was not statistically significant. A non-significant increase in the risk of subsequent ischemic stroke development for the EOC patients is demonstrated in this study.
authors.affiliation: Graduate Institute of Basic Medical Science, China Medical University, Taichung, 40402, Taiwan.|Department of Health and Nutrition Biotechnology, Asia University, Taichung, 41354, Taiwan.
authors.forename: Chih-Yang
authors.initials: CY
authors.lastname: Huang
authors.affiliation: Graduate Institute of Basic Medical Science, China Medical University, Taichung, 40402, Taiwan.|Biomaterials Translational Research Center, China Medical University Hospital, Taichung, 40402, Taiwan.
authors.forename: Tung-Sheng
authors.initials: TS
authors.lastname: Chen
authors.affiliation: Management Office for Health Data, China Medical University Hospital, Taichung, 40447, Taiwan.
authors.forename: Cheng-Li
authors.initials: CL
authors.lastname: Lin
authors.affiliation: School of Medicine, College of Medicine, China Medical University, Taichung, 40402, Taiwan. weisyunhu@gmail.com.|Division of Cardiovascular Medicine, Department of Medicine, China Medical University Hospital, 2, Yuh-Der Road, Taichung, 40447, Taiwan. weisyunhu@gmail.com.
authors.forename: Wei-Syun
authors.initials: WS
authors.lastname: Hu
mesh_terms: D000328:Adult; D002386:Cataract / Q000150:complications* / Q000453:epidemiology; D015331:Cohort Studies; D015897:Comorbidity; D003324:Coronary Artery Disease / Q000453:epidemiology; D003920:Diabetes Mellitus / Q000453:epidemiology; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000453:epidemiology; D006973:Hypertension / Q000453:epidemiology; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D020521:Stroke / Q000453:epidemiology / Q000209:etiology*; D013624:Taiwan / Q000453:epidemiology
keywords: Early onset cataract; Incidence; Ischemic stroke