title: Novel four-sided neural probe fabricated by a thermal lamination process of polymer films.
abstract: Ideally, neural probes should have channels with a three-dimensional (3-D) configuration to record the activities of 3-D neural circuits. Many types of 3-D neural probes have been developed; however, most of them were designed as an array of multiple shanks with electrodes located along one side of the shanks.
  
  
  
  We developed a novel liquid crystal polymer (LCP)-based neural probe with four-sided electrodes. This probe has electrodes on four sides of the shank, i.e., the front, back and two sidewalls. To generate the proposed configuration of the electrodes, we used a thermal lamination process involving LCP films and laser micromachining.
  
  
  
  The proposed novel four-sided neural probe, was used to successfully perform in vivo multichannel neural recording in the mouse primary somatosensory cortex.
  
  
  
  The multichannel neural recording showed that the proposed four-sided neural probe can record spiking activities from a more diverse neuronal population than single-sided probes. This was confirmed by a pairwise Pearson correlation coefficient (Pearson's r) analysis and a cross-correlation analysis.
  
  
  
  The developed four-sided neural probe can be used to record various signals from a complex neural network.
authors.affiliation: Department of Electrical and Computer Engineering, Seoul National University, Seoul, Republic of Korea; Inter-University Semiconductor Research Center, Seoul National University, Seoul, Republic of Korea.
authors.forename: Soowon
authors.initials: S
authors.lastname: Shin
authors.affiliation: Department of Biological Sciences, KAIST, Daejeon, Republic of Korea.
authors.forename: Jae-Hyun
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Department of Electrical and Computer Engineering, Seoul National University, Seoul, Republic of Korea; Inter-University Semiconductor Research Center, Seoul National University, Seoul, Republic of Korea.
authors.forename: Joonsoo
authors.initials: J
authors.lastname: Jeong
authors.affiliation: Department of Electrical and Computer Engineering, Seoul National University, Seoul, Republic of Korea; Inter-University Semiconductor Research Center, Seoul National University, Seoul, Republic of Korea.
authors.forename: Tae Mok
authors.initials: TM
authors.lastname: Gwon
authors.affiliation: Department of Biological Sciences, KAIST, Daejeon, Republic of Korea.
authors.forename: Seung-Hee
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Department of Electrical and Computer Engineering, Seoul National University, Seoul, Republic of Korea; Inter-University Semiconductor Research Center, Seoul National University, Seoul, Republic of Korea. Electronic address: kimsj@snu.ac.kr.
authors.forename: Sung June
authors.initials: SJ
authors.lastname: Kim
mesh_terms: D000200:Action Potentials; D000818:Animals; D017097:Electric Impedance; D004867:Equipment Design; D008810:Mice, Inbred C57BL; D008839:Microelectrodes; D008855:Microscopy, Electron, Scanning; D055616:Microtechnology; D009474:Neurons / Q000502:physiology; D011108:Polymers; D013003:Somatosensory Cortex / Q000502:physiology
chemical_list: D011108:Polymers; C422409:liquid crystal polymer
keywords: Liquid crystal polymer (LCP); Neural depth probe; Polymer-based depth probe; Three-dimensional neural probe