title: [Effects of genetic polymorphisms of GSTT1 and GSTM1 on metabolism of Polycyclic aromatic hydrocarbon in coal tar pitch workers].
abstract: Objective:To investigate the influence of genetic polymorphisms of GSTT1 and GSTM1 on metabolism of polycyclic aromatic hydrocarbon (PAHs) in coal tar pitch workers and to explore the effective bio-marker of occupational exposure to coal tar pitch.Methods:374 cases of workers exposed to coal tar pitch work at the enterprise which use and product coal tar pitch in Shan Dong province named as exposure group.The ad-ministrative and the support staff 135 cases were selected as control group.The concentration of the metabolic product in urine by HPLC/MC.The genetic polymorphisms of GSTT1 and GSTM1 were detected by multiple PCR method.Results:The content of metabolic product in smoke group were significantly higher than workers do not smoke (P<0.05) . The content of metabolic product in exposure group were significantly higher than control group (P<0.05) . The content of metabolic product in workers carry positive GSTT1 and GSTM1 were significantly high-er than workers carry negative one (P<0.05) . The content of metabolic product in different types of labor were significantly different (P<0.05) . The content of metabolic product were significantly higher in urine after work than before work (P<0.05) . The content of metabolic product and workers carry positive GSTT1 and GSTM1 had a positive correlation (P<0.05) .Conclusion:Carrying positive GSTT1 and GSTM1 promote polycyclic aromatic hydrocarbons in the body's metabolism.
authors.affiliation: School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Shandong Institute of Prevention and Control of Occupational Disease, Jinan250062, China.
authors.forename: X C
authors.initials: XC
authors.lastname: Sun
authors.forename: F
authors.initials: F
authors.lastname: Zhang
authors.forename: W
authors.initials: W
authors.lastname: Zhang
authors.forename: H
authors.initials: H
authors.lastname: Shao
authors.forename: Z X
authors.initials: ZX
authors.lastname: Wang
mesh_terms: D003033:Coal Tar; D005982:Glutathione Transferase / Q000378:metabolism*; D006801:Humans; D008297:Male; D016273:Occupational Exposure; D011084:Polycyclic Aromatic Hydrocarbons / Q000378:metabolism*; D011110:Polymorphism, Genetic; D012906:Smoke
chemical_list: D003033:Coal Tar; D005982:Glutathione Transferase; D011084:Polycyclic Aromatic Hydrocarbons; D012906:Smoke; C413545:glutathione S-transferase T1