title: Enantioselective Synthesis of Oxetanes Bearing All-Carbon Quaternary Stereocenters via Iridium-Catalyzed C-C Bond-Forming Transfer Hydrogenation.
abstract: Oxetanes bearing all-carbon quaternary stereocenters are readily prepared through the iridium-catalyzed anti-diastereo- and enantioselective C-C coupling of primary alcohols and isoprene oxide. Based on this methodology, an oxetane containing analogue of haloperidol was prepared. A related azetidine formation is also described.
authors.affiliation: University of Texas at Austin, Department of Chemistry, 1 University Station-A5300, Austin, TX, 78712-1167, USA.
authors.forename: Yi-An
authors.initials: YA
authors.lastname: Guo
authors.affiliation: University of Texas at Austin, Department of Chemistry, 1 University Station-A5300, Austin, TX, 78712-1167, USA.
authors.forename: Wonchul
authors.initials: W
authors.lastname: Lee
authors.affiliation: University of Texas at Austin, Department of Chemistry, 1 University Station-A5300, Austin, TX, 78712-1167, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Krische
keywords: enantioselectivity; iridium; oxetane; quaternary center; transfer hydrogenation