title: Establish Albumin-creatinine Ratio Reference Valueof Adults in the Rural Area of Hebei Province.
abstract: Objective To establish albumin-creatinine ratio (ACR) reference value of the rural population in Hebei province.Methods This study enrolled 5154 participants. By excluding subjects with hypertension, diabetes, dyslipidemia, cardiovascular and cerebrovascular diseases, kidney diseases, and overweight condition, as well as those with an estimated glomerular filtration rate (eGFR)<60 ml/(min·1.73 m2), apparently healthy subjects (1168) were selected. Urine albumin was measured by using the immunoturbidimetic method, serum creatinine was measured by using Jaffe's kinetic method on a morning spot-urine sample, and ACR was calculated. The 95th percentile of ACR in the healthy subjects was used as the normal upper limit.Results The normal upper limit of ACR was 28.71 mg/g (3.25 mg/mmol) for males and 31.85 mg/g (3.60 mg/mmol) for females. Based on this ACR reference value, the age-gender standardized prevalence of albuminuria in the rural areas of Hebei province was 12.9%.Conclusion The ACR reference value in the rural of Hebei province is higher than that of the Western population.
authors.affiliation: Department of Nephrology, Capital Medical University, Beijing 100730, China.
authors.forename: Qiao-Jing
authors.initials: QJ
authors.lastname: Liang
authors.affiliation: Department of Nephrology, Capital Medical University, Beijing 100730, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Huang
authors.affiliation: Department of Nephrology, Capital Medical University, Beijing 100730, China.
authors.forename: Guo-Juan
authors.initials: GJ
authors.lastname: Zhang
authors.affiliation: Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
authors.forename: Ning-Li
authors.initials: NL
authors.lastname: Wang
mesh_terms: D000328:Adult; D000418:Albumins / Q000032:analysis*; D000419:Albuminuria; D003404:Creatinine / Q000032:analysis*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007674:Kidney Diseases; D008297:Male
chemical_list: D000418:Albumins; D003404:Creatinine