title: Influence of T1-Weighted Signal Intensity on FSL Voxel-Based Morphometry and FreeSurfer Cortical Thickness.
abstract: The effect of T1 signal on FSL voxel-based morphometry modulated GM density and FreeSurfer cortical thickness is explored. The techniques rely on different analyses, but both are commonly used to detect spatial changes in GM. Standard pipelines show FSL voxel-based morphometry is sensitive to T1 signal alterations within a physiologic range, and results can appear discordant between FSL voxel-based morphometry and FreeSurfer cortical thickness. Care should be taken in extrapolating results to the effect on brain volume.
authors.affiliation: From the Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, and Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, New York.
authors.forename: S
authors.identifier: 0000-0002-1132-900X
authors.initials: S
authors.lastname: Chung
authors.affiliation: From the Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, and Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, New York.
authors.forename: X
authors.identifier: 0000-0001-6356-3386
authors.initials: X
authors.lastname: Wang
authors.affiliation: From the Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, and Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, New York. yvonne.lui@nyumc.org.
authors.forename: Y W
authors.identifier: 0000-0002-9984-9164
authors.initials: YW
authors.lastname: Lui
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D059906:Neuroimaging / Q000379:methods*