title: Therapeutic effect of mesenchymal stem cells on experimentally induced hypertensive cardiomyopathy in adult albino rats.
abstract: Hypertensive heart diseases affect millions of people worldwide. We aimed to investigate the hypertensive left ventricular histological changes and assess the effectiveness of bone marrow derived mesenchymal stem cells (MSCs) therapy in the treatment of hypertensive cardiomyopathy. Adult male albino rats were assigned into two groups: group I (control), group II (Experimental) subdivided into subgroup IIa (hypertensive) and subgroup IIb (stem cell therapy). Left ventricles (LVs) were processed for light and electron microscope. Mallory's trichrome and immunostaining for caspase-3 and desmin were carried out. Hypertension caused left ventricular histological and immunohistochemical changes that had been effectively improved by MSCs therapy.
authors.affiliation: a Department of Histology and Cell Biology, Faculty of Medicine , Zagazig University , Zagazig , Egypt.
authors.forename: Nariman A
authors.initials: NA
authors.lastname: Khater
authors.affiliation: a Department of Histology and Cell Biology, Faculty of Medicine , Zagazig University , Zagazig , Egypt.
authors.forename: Sally A
authors.initials: SA
authors.lastname: Selim
authors.affiliation: a Department of Histology and Cell Biology, Faculty of Medicine , Zagazig University , Zagazig , Egypt.
authors.forename: Samia A
authors.initials: SA
authors.lastname: Abd El-Baset
authors.affiliation: a Department of Histology and Cell Biology, Faculty of Medicine , Zagazig University , Zagazig , Egypt.
authors.forename: Samar H
authors.initials: SH
authors.lastname: Abd El Hameed
mesh_terms: D000818:Animals; D009202:Cardiomyopathies / Q000209:etiology / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D053148:Caspase 3 / Q000378:metabolism; D002478:Cells, Cultured; D003893:Desmin / Q000378:metabolism; D004195:Disease Models, Animal; D006352:Heart Ventricles / Q000378:metabolism / Q000503:physiopathology* / Q000648:ultrastructure; D006978:Hypertension, Renovascular / Q000150:complications* / Q000503:physiopathology; D017379:Hypertrophy, Left Ventricular / Q000209:etiology / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D007150:Immunohistochemistry; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation; D046529:Microscopy, Electron, Transmission; D051381:Rats; D012038:Regeneration; D013194:Staining and Labeling / Q000379:methods; D016277:Ventricular Function, Left; D020257:Ventricular Remodeling
chemical_list: D003893:Desmin; C505410:Casp3 protein, rat; D053148:Caspase 3
keywords: Cardiac muscle; hypertension; mesenchymal stem cells; rat