title: Self-Reported Questionnaire Detects Family History of Cancer in a Pancreatic Cancer Screening Program.
abstract: Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer death; approximately 5-10% of PDAC is hereditary. Self-administered health history questionnaires (HHQs) may provide a low-cost method to detail family history (FH) of malignancy. Pancreas Center patients were asked to enroll in a registry; 149 with PDAC completed a HHQ which included FH data. Patients with FH of PDAC, or concern for inherited PDAC syndrome, were separately evaluated in a Prevention Program and additionally met with a genetic counselor (GC) to assess PDAC risk (n = 61). FH obtained through GC and HHQ were compared using Wilcoxon signed-rank sum and generalized linear mixed models with Poisson distribution. Agreement between GC and HHQ risk-assessment was assessed using kappa (κ) statistic. In the Prevention Program, HHQ was as precise in detecting FH of cancer as the GC (all p > 0.05). GC and HHQ demonstrated substantial agreement in risk-stratification of the Prevention Program cohort (κ = 0.73, 95% CI 0.59-0.87.) The sensitivity of the HHQ to detect a patient at elevated risk (i.e., moderate- or high-risk) of PDAC, compared to GC, was 82.9% (95% CI 67.3-92.3%) with a specificity of 95% (95% CI 73.1-99.7%). However, seven patients who were classified as average-risk by the HHQ were found to be at an elevated-risk of PDAC by the GC. In the PDAC cohort, 30/149 (20.1%) reported at least one first-degree relative (FDR) with PDAC. The limited sensitivity of the HHQ to detect patients at elevated risk of PDAC in the Prevention Program cohort suggests that a GC adds value in risk-assessment in this population. The HHQ may offer an opportunity to identify high-risk patients in a PDAC population.
authors.affiliation: Henry D. Janowitz Division of Gastroenterology, Samuel Bronfman Department of Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1069, New York, NY, 10029, USA. aimee.lucas@mssm.edu.
authors.forename: Aimee L
authors.initials: AL
authors.lastname: Lucas
authors.affiliation: Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, 10032, USA.
authors.forename: Adam
authors.initials: A
authors.lastname: Tarlecki
authors.affiliation: Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, 10032, USA.
authors.forename: Kellie
authors.initials: K
authors.lastname: Van Beck
authors.affiliation: Division of Gastroenterology, Department of Medicine, Columbia University, New York, NY, 10032, USA.
authors.forename: Casey
authors.initials: C
authors.lastname: Lipton
authors.affiliation: Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY, 10032, USA.
authors.forename: Arindam
authors.initials: A
authors.lastname: RoyChoudhury
authors.affiliation: Cancer Genetics Program, New York Presbyterian Hospital, New York, NY, 10032, USA.
authors.forename: Elana
authors.initials: E
authors.lastname: Levinson
authors.affiliation: National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.
authors.forename: Sheila
authors.initials: S
authors.lastname: Kumar
authors.affiliation: Division of Molecular Genetics, Department of Pediatrics, Columbia University, New York, NY, 10032, USA.|Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, 10032, USA.
authors.forename: Wendy K
authors.initials: WK
authors.lastname: Chung
authors.affiliation: Division of Gastroenterology, Department of Medicine, Columbia University, New York, NY, 10032, USA.
authors.forename: Harold
authors.initials: H
authors.lastname: Frucht
authors.affiliation: Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, 10032, USA.|Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, 10032, USA.
authors.forename: Jeanine M
authors.initials: JM
authors.lastname: Genkinger
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D055088:Early Detection of Cancer; D005260:Female; D006801:Humans; D008297:Male; D008487:Medical History Taking; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000517:prevention & control*; D057566:Self Report / Q000592:standards; D012680:Sensitivity and Specificity; D011795:Surveys and Questionnaires / Q000592:standards*
keywords: Genetic counselor; Health history questionnaire; Hereditary pancreatic cancer; Pancreatic cancer; Pancreatic ductal adenocarcinoma