title: Comparison between ultra-high and conventional mono b-value DWI for preoperative glioma grading.
abstract: To compare the efficacy of ultra-high and conventional mono-b-value DWI for glioma grading, in 109 pathologically confirmed glioma patients, ultra-high apparent diffusion coefficient (ADCuh)was calculated using a tri-exponential mode, distributed diffusion coefficients (DDCs) and α values were calculated using a stretched-exponential model, and conventional ADC values were calculated using a mono-exponential model. The efficacy and reliability of parameters for grading gliomas were investigated using receiver operating characteristic (ROC) curve and intra-class correlation (ICC) analyses, respectively. The ADCuh values differed (P < 0.001) between low-grade gliomas (LGGs; 0.436 ×10-3 mm2/sec) and high-grade gliomas (HGGs; 0.285 × 10-3 mm2/sec). DDC, a and various conventional ADC values were smaller in HGGs (all P ≤ 0.001, vs. LGGs). The ADCuh parameter achieved the highest diagnostic efficacy with an area under curve (AUC) of 0.993, 92.9% sensitivity and 98.8% specificity for glioma grading at a cutoff value of 0.362×10-3 mm2/sec. ADCuh measurement appears to be an easy-to-perform technique with good reproducibility (ICC = 0.9391, P < 0.001). The ADCuh value based in a tri-exponential model exhibited greater efficacy and reliability than other DWI parameters, making it a promising technique for glioma grading.
authors.affiliation: Department of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
authors.forename: Yu-Chuan
authors.initials: YC
authors.lastname: Hu
authors.affiliation: Department of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
authors.forename: Lin-Feng
authors.initials: LF
authors.lastname: Yan
authors.affiliation: Department of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Sun
authors.affiliation: Department of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
authors.forename: Zhi-Cheng
authors.initials: ZC
authors.lastname: Liu
authors.affiliation: Department of Pathology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
authors.forename: Shu-Mei
authors.initials: SM
authors.lastname: Wang
authors.affiliation: Department of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Han
authors.affiliation: Department of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Tian
authors.affiliation: Department of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
authors.forename: Ying-Zhi
authors.initials: YZ
authors.lastname: Sun
authors.affiliation: MR Research China, GE Healthcare China, Beijing, China.
authors.forename: Dan-Dan
authors.initials: DD
authors.lastname: Zheng
authors.affiliation: Department of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
authors.forename: Guang-Bin
authors.initials: GB
authors.lastname: Cui
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005910:Glioma / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D055815:Young Adult
keywords: MRI; apparent diffusion coefficient; diffusion-weighted imaging; glioma; grading