title: Pd-Catalyzed Dimethylation of Tyrosine-Derived Picolinamide for Synthesis of (S)-N-Boc-2,6-dimethyltyrosine and Its Analogues.
abstract: A short and efficient synthesis of (S)-N-Boc-2,6-dimethyltyrosine utilizing palladium-catalyzed directed C-H functionalization is described. This represents the first general method for the ortho-dimethylation of tyrosine derivatives and offers a practical approach for preparing this synthetically important building block. Notably, throughout the reaction sequence no racemization occurs at the susceptible α-chiral centers.
authors.affiliation: Shenyang Pharmaceutical University , 103 Wenhua Lu, Shenyang 110016, China.
authors.forename: Xuning
authors.initials: X
authors.lastname: Wang
authors.affiliation: Shenyang Pharmaceutical University , 103 Wenhua Lu, Shenyang 110016, China.
authors.forename: Songtao
authors.initials: S
authors.lastname: Niu
authors.affiliation: State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , 345 Lingling Lu, Shanghai 200032, China.
authors.forename: Lanting
authors.initials: L
authors.lastname: Xu
authors.affiliation: State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , 345 Lingling Lu, Shanghai 200032, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , 345 Lingling Lu, Shanghai 200032, China.
authors.forename: Lingxing
authors.initials: L
authors.lastname: Meng
authors.affiliation: Shenyang Pharmaceutical University , 103 Wenhua Lu, Shenyang 110016, China.
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , 345 Lingling Lu, Shanghai 200032, China.
authors.forename: Dawei
authors.identifier: 0000-0002-1721-7551
authors.initials: D
authors.lastname: Ma