title: Genomic effects of glucocorticoids.
abstract: Glucocorticoids and their receptor (GR) have been an important area of research because of their pleiotropic physiological functions and extensive use in the clinic. In addition, the association between GR and glucocorticoids, which is highly specific, leads to rapid nuclear translocation where GR associates with chromatin to regulate gene transcription. This simplified model system has been instrumental for studying the complexity of transcription regulation processes occurring at chromatin. In this review we discuss our current understanding of GR action that has been enhanced by recent developments in genome wide measurements of chromatin accessibility, histone marks, chromatin remodeling and 3D chromatin structure in various cell types responding to glucocorticoids.
authors.affiliation: The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Building 206, 5290002, Ramat-Gan, Israel.
authors.forename: Ivana
authors.initials: I
authors.lastname: Grbesa
authors.affiliation: The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Building 206, 5290002, Ramat-Gan, Israel. ofir.hakim@biu.ac.il.
authors.forename: Ofir
authors.identifier: http://orcid.org/0000-0003-0063-2721
authors.initials: O
authors.lastname: Hakim
mesh_terms: D000818:Animals; D001665:Binding Sites; D002843:Chromatin / Q000502:physiology*; D042002:Chromatin Assembly and Disassembly / Q000502:physiology*; D005786:Gene Expression Regulation / Q000502:physiology*; D005938:Glucocorticoids / Q000378:metabolism*; D006801:Humans; D051379:Mice; D011401:Promoter Regions, Genetic; D011485:Protein Binding; D011965:Receptors, Glucocorticoid / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D002843:Chromatin; D005938:Glucocorticoids; D011965:Receptors, Glucocorticoid
keywords: ChIP-seq; Chromatin; Chromatin accessibility; Enhancers; Glucocorticoid receptor; Glucocorticoids; Long-range interactions; Transcription; Transcription factor