title: Termisoflavones A-C, Isoflavonoid Glycosides from Termite-Associated Streptomyces sp. RB1.
abstract: Three new isoflavonoid glycosides, termisoflavones A-C (1-3), and eight isoflavonoids (4-11) were isolated from termite-associated Streptomyces sp. RB1 recovered from the cuticle of the South African termite, Macrotermes natalensis. The structures of new compounds were determined by spectroscopic methods including 1D and 2D NMR and HR-MS analysis, as well as comparison of their NMR data with those of related isoflavonoid glycoside derivatives. The absolute configurations of the sugar moieties were clarified by chemical reactions. None of the isolates (1-11) displayed antifungal or antimicrobial activities (MICs > 100 μg/mL), whereas compounds 6 and 11 ameliorated cisplatin-induced kidney cell damage to 80% of the control value at a cisplatin dose of 25 μM.
authors.affiliation: School of Pharmacy, Sungkyunkwan University , Suwon 440-746, Republic of Korea.
authors.forename: Hee Rae
authors.initials: HR
authors.lastname: Kang
authors.affiliation: School of Pharmacy, Sungkyunkwan University , Suwon 440-746, Republic of Korea.
authors.forename: Dahae
authors.initials: D
authors.lastname: Lee
authors.affiliation: Leibniz Institute for Natural Product Research and Infection Biology e.V., Hans-Knöll-Institute (HKI) , Beutenbergstrasse 11a, 07745 Jena, Germany.
authors.forename: René
authors.initials: R
authors.lastname: Benndorf
authors.affiliation: Department of Systems Biotechnology, Chung-Ang University , Anseong, Gyeonggi-do 456-756, Republic of Korea.
authors.forename: Won Hee
authors.initials: WH
authors.lastname: Jung
authors.affiliation: Leibniz Institute for Natural Product Research and Infection Biology e.V., Hans-Knöll-Institute (HKI) , Beutenbergstrasse 11a, 07745 Jena, Germany.
authors.forename: Christine
authors.initials: C
authors.lastname: Beemelmanns
authors.affiliation: College of Korean Medicine, Gachon University , Seongnam 461-701, Republic of Korea.
authors.forename: Ki Sung
authors.initials: KS
authors.lastname: Kang
authors.affiliation: School of Pharmacy, Sungkyunkwan University , Suwon 440-746, Republic of Korea.
authors.forename: Ki Hyun
authors.identifier: http://orcid.org/0000-0002-5285-9138
authors.initials: KH
authors.lastname: Kim
mesh_terms: D000111:Acetylcysteine / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D002945:Cisplatin / Q000494:pharmacology; D003454:Cryptococcus / Q000187:drug effects; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification*; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification*; D020049:Isoptera / Q000382:microbiology*; D007668:Kidney / Q000166:cytology / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013019:South Africa; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D006027:Glycosides; D007529:Isoflavones; C000618071:termisoflavone A; C000618038:termisoflavone B; C000618039:termisoflavone C; D002945:Cisplatin; D000111:Acetylcysteine