title: Zwitterionic Iron Oxide (γ-Fe2O3) Nanoparticles Based on P(2VP-grad-AA) Copolymers.
abstract: This study presents the synthesis and characterization of zwitterionic core-shell hybrid nanoparticles consisting of a core of iron oxide multicore nanoparticles (MCNPs, γ-Fe2O3) and a shell of sultonated poly(2-vinylpyridine-grad-acrylic acid) copolymers. The gradient copolymers are prepared by reversible addition fragmentation chain transfer polymerization of 2-vinylpyridine (2VP), followed by the addition of tert-butyl acrylate and subsequent hydrolysis. Grafting of P(2VP-grad-AA) onto MCNP results in P(2VP-grad-AA)@MCNP, followed by quaternization using 1,3-propanesultone-leading to P(2VPS-grad-AA)@MCNP with a zwitterionic shell. The resulting particles are characterized by transmission electron microscopy, dynamic light scattering, and thermogravimetric analysis measurements, showing particle diameters of ≈70-90 nm and an overall content of the copolymer shell of ≈10%. Turbidity measurements indicate increased stability toward secondary aggregation after coating if compared to the pristine MCNP and additional cytotoxicity tests do not reveal any significant influence on cell viability.
authors.affiliation: Laboratory of Organic and Macromolecular Chemistry, Friedrich-Schiller-University Jena, Humboldtstraße 10, D-07743, Jena, Germany.|Jena Center for Soft Matter (JCSM), Friedrich-Schiller-University Jena, Philosophenweg 7, D-07743, Jena, Germany.
authors.forename: Mark
authors.initials: M
authors.lastname: Billing
authors.affiliation: Klinik für Innere Medizin II, Abteilung Hämatologie und Internistische Onkologie, Universitätsklinikum Jena, Am Klinikum 1, D.07747, Jena, Germany.
authors.forename: Christine
authors.initials: C
authors.lastname: Gräfe
authors.affiliation: Laboratory of Organic and Macromolecular Chemistry, Friedrich-Schiller-University Jena, Humboldtstraße 10, D-07743, Jena, Germany.|Jena Center for Soft Matter (JCSM), Friedrich-Schiller-University Jena, Philosophenweg 7, D-07743, Jena, Germany.
authors.forename: Adrian
authors.initials: A
authors.lastname: Saal
authors.affiliation: Laboratory of Organic and Macromolecular Chemistry, Friedrich-Schiller-University Jena, Humboldtstraße 10, D-07743, Jena, Germany.|Jena Center for Soft Matter (JCSM), Friedrich-Schiller-University Jena, Philosophenweg 7, D-07743, Jena, Germany.
authors.forename: Philip
authors.initials: P
authors.lastname: Biehl
authors.affiliation: Jena Center for Soft Matter (JCSM), Friedrich-Schiller-University Jena, Philosophenweg 7, D-07743, Jena, Germany.|Klinik für Innere Medizin II, Abteilung Hämatologie und Internistische Onkologie, Universitätsklinikum Jena, Am Klinikum 1, D.07747, Jena, Germany.
authors.forename: Joachim H
authors.initials: JH
authors.lastname: Clement
authors.affiliation: Institute of Biomedical Engineering and Informatics, Technische Universität Ilmenau, Gustav-Kirchhoff-Str. 2, D.98693, Ilmenau, Germany.
authors.forename: Silvio
authors.initials: S
authors.lastname: Dutz
authors.affiliation: Bundesanstalt für Materialforschung und -prüfung (BAM), Richard-Willstätter-Str. 11, D-12489, Berlin, Germany.
authors.forename: Steffen
authors.initials: S
authors.lastname: Weidner
authors.affiliation: Laboratory of Organic and Macromolecular Chemistry, Friedrich-Schiller-University Jena, Humboldtstraße 10, D-07743, Jena, Germany.|Jena Center for Soft Matter (JCSM), Friedrich-Schiller-University Jena, Philosophenweg 7, D-07743, Jena, Germany.
authors.forename: Felix H
authors.initials: FH
authors.lastname: Schacher
mesh_terms: D000180:Acrylic Resins / Q000138:chemical synthesis / Q000737:chemistry*; D005290:Ferric Compounds / Q000737:chemistry*; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D011145:Polyvinyls / Q000138:chemical synthesis / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D000180:Acrylic Resins; D005290:Ferric Compounds; D011145:Polyvinyls; C000499:ferric oxide
keywords: block copolymer; controlled radical polymerization; hybrid nanoparticles; iron oxide nanoparticles; sulfobetaines