title: Analysis of treatment outcomes for primary tonsillar lymphoma.
abstract: OBJECTIVE
  Although each Waldeyer's ring sub-site is considered an independent prognostic factor, few studies have assessed the prognosis and treatment of tonsillar lymphoma. Treatment outcomes were analyzed in patients with primary tonsillar lymphoma who were treated with chemotherapy and radiotherapy (RT).
  
  
  METHODS
  Nineteen patients with diffuse large B-cell lymphoma were evaluated, with a median follow-up of 53 months. Age, sex, and histology, amongst other factors, were reviewed. Progression-free survival (PFS) and overall survival (OS) rates were analyzed.
  
  
  RESULTS
  Most patients had Ann Arbor stage I-II (94.7%), IPI score of 0 (89.5%), and complete remission after chemotherapy (89.5%). The 5-year PFS and OS rates were 74.6% and 80%, respectively. In univariate analysis, the rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) regimen resulted in a better PFS than the cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) regimen (88.9% vs. 50.0%; p = 0.053). RT dose was related to the survival outcome (p = 0.010 for PFS, p = 0.044 for OS). Patients were classified into the CHOP + RT (>40 Gy) group and R-CHOP + RT (≤40 Gy) group. The 5-year PFS rates were 50% in the CHOP + RT group, and 100 % in the R-CHOP + RT group (p = 0.018). The 5-year OS rates were 66.7% and 100%, respectively (p = 0.087).
  
  
  CONCLUSIONS
  Primary tonsillar lymphoma patients typically have favorable outcomes. Chemotherapy (R-CHOP) combined with relatively lower dose consolidative RT may be safe and effective for primary tonsillar lymphoma.
authors.affiliation: Department of Radiation Oncology, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, Korea.
authors.forename: Yun Hee
authors.initials: YH
authors.lastname: Lee
authors.affiliation: Department of Hematology, Catholic University Lymphoma Group (CULG), Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Seok Goo
authors.initials: SG
authors.lastname: Cho
authors.affiliation: Department of Radiology, Catholic University Lymphoma Group (CULG), Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Seung Eun
authors.initials: SE
authors.lastname: Jung
authors.affiliation: Department of Nuclear Medicine, Catholic University Lymphoma Group (CULG), Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Sung Hoon
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Department of Nuclear Medicine, Catholic University Lymphoma Group (CULG), Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Joo Hyun
authors.initials: JH
authors.lastname: O
authors.affiliation: Department of Pathology, Catholic University Lymphoma Group (CULG), Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Gyeong Sin
authors.initials: GS
authors.lastname: Park
authors.affiliation: Department of Ophthalmology, Catholic University Lymphoma Group (CULG), Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Suk Woo
authors.initials: SW
authors.lastname: Yang
authors.affiliation: Department of Internal Medicine, Catholic University Lymphoma Group (CULG), Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: In Seok
authors.initials: IS
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Catholic University Lymphoma Group (CULG), Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Chin Kook
authors.initials: CK
authors.lastname: Rhee
authors.affiliation: Department of Radiation Oncology, Catholic University Lymphoma Group (CULG), Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Byung Ock
authors.initials: BO
authors.lastname: Choi
keywords: Non-Hodgkin lymphoma; Palatine Tonsil; Radiotherapy