title: Physcion induces apoptosis in hepatocellular carcinoma by modulating miR-370.
abstract: Hepatocellular carcinoma (HCC) is one of the most common and aggressive malignancies. The current study is designed to explore the role of physcion, a major active ingredient in several traditional herbal medicinal plants, for the treatment of HCC. HCC cell lines, SMMC7721 and HepG2, were treated with physcion and its apoptosis-inducing effect was examined. Both in vitro and in vivo results from the present study demonstrated that physcion treatment resulted in apoptotic cell death in HCC cells via upregulation of miR-370. Furthermore, our findings showed that the physcion modulated the level of miR-370 through AMPK/Sp1/DNMT1 signaling. Taken together, these results showed that physcion exerts anti-tumor effect against HCC, which may be a potential agent for the adjunct chemotherapy.
authors.affiliation: The People's Hospital of Wuhai Inner Mongolia, PR China.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Pan
authors.affiliation: The People's Hospital of Wuhai Inner Mongolia, PR China.
authors.forename: Haixia
authors.initials: H
authors.lastname: Wang
authors.affiliation: The People's Hospital of Wuhai Inner Mongolia, PR China.
authors.forename: Dongmeng
authors.initials: D
authors.lastname: Tong
authors.affiliation: The People's Hospital of Wuhai Inner Mongolia, PR China.
authors.forename: Chen
authors.initials: C
authors.lastname: Wang
authors.affiliation: The Mongolian medical & TCM Hospital of Wuhai Inner Mongolia, PR China.
authors.forename: Li
authors.initials: L
authors.lastname: Sun
authors.affiliation: The Mongolian medical & TCM Hospital of Wuhai Inner Mongolia, PR China.
authors.forename: Chunjuan
authors.initials: C
authors.lastname: Zhao
authors.affiliation: The People's Hospital of Wuhai Inner Mongolia, PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: The People's Hospital of Wuhai Inner Mongolia, PR China.
authors.forename: Lida
authors.initials: L
authors.lastname: Zhu
authors.affiliation: The People's Hospital of Wuhai Inner Mongolia, PR China.
authors.forename: Di
authors.initials: D
authors.lastname: Wu
keywords: DNMT1; Physcion; apoptosis; miR-370