title: Association of human leukocyte A, B, and DR antigens in Colombian patients with diagnosis of spondyloarthritis.
abstract: There is substantial evidence that non-B27 major histocompatibility complex (MHC) genes are associated with spondyloarthritis (SpA). Studies in Mexican and Tunisian populations demonstrated the association of SpA and human leukocyte antigen (HLA) B15. The purpose of this study was to evaluate the association of HLA-A, B, and DR antigens in a group of Colombian patients with a diagnosis of SpA. A total of 189 patients and 100 healthy subjects were included in the present study. All subjects underwent a complete characterization of HLA alleles A, B, and DR. Of the 189 studied patients, 35 were reactive arthritis (ReA), 87 were ankylosing spondylitis (AS), and 67 undifferentiated SpA (uSpA). According to the Assessment of Spondyloarthritis International Society (ASAS) criteria, 167 were axial SpA (axSpA) and 171 were peripheral SpA (pSpA). 63.8% were men, with a mean age of 35.9 ± 12.7 years. 40.7% (77/189) of patients were HLA-B27 positive of which 52.9% had AS and 42.5% axSpA. 23.2% (44/189) of patients were HLA-B15 positive: 23.8% were uSpA, 12.57% were axSpA, and 11.7% were pSpA. In addition, HLA-DRB1*01 was associated with AS (58.6%) and axSpA (42.5%). Also, HLA-DRB1*04 was present in 62 patients with AS (71.2%) and in 26 with axSpA (15.5%). In this population, we found a strong association between the presence of HLA-B27 and the diagnosis of axSpA and AS, but the HLA-B15 is also significantly associated with all subtypes of the disease, predominantly with pSpA. Additionally, HLA-DR1 and DR4 were associated in a cohort of patients with SpA from Colombia.
authors.affiliation: Department of Rheumatology, Universidad de La Sabana-Hospital Militar Central, Km 7, Autopista Norte de Bogota, Chia, Colombia.
authors.forename: Ana M
authors.initials: AM
authors.lastname: Santos
authors.affiliation: Department of Rheumatology, Universidad de La Sabana-Hospital Militar Central, Km 7, Autopista Norte de Bogota, Chia, Colombia.
authors.forename: Paola
authors.initials: P
authors.lastname: Peña
authors.affiliation: Department of Rheumatology, Universidad de La Sabana-Hospital Militar Central, Km 7, Autopista Norte de Bogota, Chia, Colombia.
authors.forename: Mabel
authors.initials: M
authors.lastname: Avila
authors.affiliation: Faculty of Medicine, Grupo Genética Humana, Universidad de La Sabana, Chia, Colombia.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Briceño
authors.affiliation: Department of Biological Sciences, Universidad de Los Andes, Bogota, Colombia.
authors.forename: Carlos
authors.initials: C
authors.lastname: Jaramillo
authors.affiliation: Interventional Genetic Study Group in Cardiovascular Diseases, Department of Molecular Biology, National Institute of Cardiology Ignacio Chávez, Mexico, DF, Mexico.
authors.forename: Gilberto
authors.initials: G
authors.lastname: Vargas-Alarcon
authors.affiliation: Department of Rheumatology, Universidad de La Sabana-Hospital Militar Central, Km 7, Autopista Norte de Bogota, Chia, Colombia.
authors.forename: Juan C
authors.initials: JC
authors.lastname: Rueda
authors.affiliation: Department of Rheumatology, Universidad de La Sabana-Hospital Militar Central, Km 7, Autopista Norte de Bogota, Chia, Colombia.
authors.forename: Eugenia-Lucia
authors.initials: EL
authors.lastname: Saldarriaga
authors.affiliation: Department of Rheumatology, Universidad de La Sabana-Hospital Militar Central, Km 7, Autopista Norte de Bogota, Chia, Colombia.
authors.forename: Jose-Ignacio
authors.initials: JI
authors.lastname: Angarita
authors.affiliation: Community Health Research Department, Ministry of Health (SSA), Hospital Infantil de México Federico Gomez, Mexico, DF, Mexico.
authors.forename: Nancy
authors.initials: N
authors.lastname: Martinez-Rodriguez
authors.affiliation: Department of Rheumatology, Universidad de La Sabana-Hospital Militar Central, Km 7, Autopista Norte de Bogota, Chia, Colombia. john.londono@unisabana.edu.co.
authors.forename: John
authors.initials: J
authors.lastname: Londono
mesh_terms: D000328:Adult; D016918:Arthritis, Reactive / Q000175:diagnosis / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D059910:HLA-B15 Antigen / Q000235:genetics*; D015796:HLA-B27 Antigen / Q000235:genetics*; D059811:HLA-DRB1 Chains / Q000235:genetics*; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D000091402:Prohibitins; D013167:Spondylitis, Ankylosing / Q000175:diagnosis / Q000235:genetics*; D055815:Young Adult
chemical_list: D059910:HLA-B15 Antigen; D015796:HLA-B27 Antigen; D059811:HLA-DRB1 Chains; C000717331:PHB2 protein, human; D000091402:Prohibitins
keywords: Allele frequency; Colombia; Genetics; HLA-B15; Humans; Spondyloarthritis