title: Perspectives of In Vivo Bioluminescence Imaging: Application to Basic and Translational Neuroscience.
abstract: In vivo bioluminescence imaging has been used extensively for screening assays and for qualitative determination of localization of cells, in particular in cancer studies.
  
  
  
  In this review we show the potential of this noninvasive molecular imaging modality to investigate gene activity, dynamic processes, and translational disease processes, all under true in vivo conditions with the specific focus on brain.
  
  
  
  We demonstrate a range of applications of bioluminescence imaging in basic and translational neuroscience. Here, emphasis is on the contribution of bioluminescence imaging of the brain to the elucidation of cellular and genetic mechanisms, understanding of dynamic processes, and to the discussion of disease characterization and therapeutic strategies.
authors.affiliation: In-vivo-NMR Laboratory, Max Planck Institute for Metabolism Research, Cologne. Germany.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Vogel
authors.affiliation: In-vivo-NMR Laboratory, Max Planck Institute for Metabolism Research, Cologne. Germany.
authors.forename: Franziska M
authors.initials: FM
authors.lastname: Collmann
authors.affiliation: In-vivo-NMR Laboratory, Max Planck Institute for Metabolism Research, Gleuelerstrasse 50, D-50931 Cologne. Germany.
authors.forename: Mathias
authors.initials: M
authors.lastname: Hoehn
mesh_terms: D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008163:Luminescent Measurements; D057054:Molecular Imaging; D009488:Neurosciences / Q000379:methods*; D057170:Translational Research, Biomedical / Q000379:methods*
keywords: In vivo bioluminescence imaging; biological cycles; cerebral disease mechanisms; dynamic processes; neuroscience; noninvasive
  molecular imaging