title: BRAF-activated lncRNA predicts gastrointestinal cancer patient prognosis: a meta-analysis.
abstract: BRAF activated non-coding RNA (BANCR) is often dysregulated in cancer. We performed a meta-analysis to clarify its functions as a prognostic indicator in malignant tumors. We searched the PubMed, Medline, OVID, Cochrane Library, and Web of Science databases to identify BANCR-related studies. Nine original studies and 898 total patients were included in the meta-analysis. Hazard ratios (HR) and 95% confidence intervals (CI) were extracted from the included studies to determine the relationship between BANCR expression and patient overall survival (OS). Odds ratios (OR) were calculated using RevMan 5.3 software to assess associations between BANCR expression and pathological parameters. High BANCR expression correlated with lymph node metastasis (LNM) (OR = 3.41, 95% CI: 1.82-6.37, P = 0.0001), distant metastasis (DM) (OR = 2.98, 95% CI: 1.76-5.07, P < 0.0001), tumor stage (OR = 3.11, 95% CI: 1.89-5.12, Z = 3.25, P < 0.0001), and poor OS (pooled HR = 1.98, 95% CI: 1.20-3.27, P = 0.008) in gastrointestinal (GI) cancer patients, but not in non-GI cancer patients. Our results support the notion that BANCR as a promising prognostic biomarker in Chinese patients with GI cancer.
authors.affiliation: Department of Neurosurgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, People's Republic of China.
authors.forename: Yang-Hua
authors.initials: YH
authors.lastname: Fan
authors.affiliation: Department of Neurosurgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, People's Republic of China.
authors.forename: Min-Hua
authors.initials: MH
authors.lastname: Ye
authors.affiliation: Department of Neurosurgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, People's Republic of China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wu
authors.affiliation: Department of Neurosurgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, People's Republic of China.
authors.forename: Miao-Jing
authors.initials: MJ
authors.lastname: Wu
authors.affiliation: Department of Neurosurgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, People's Republic of China.
authors.forename: Shi-Gang
authors.initials: SG
authors.lastname: Lu
authors.affiliation: Department of Neurosurgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, People's Republic of China.
authors.forename: Xin-Gen
authors.initials: XG
authors.lastname: Zhu
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics*; D016009:Chi-Square Distribution; D002681:China; D005770:Gastrointestinal Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D009367:Neoplasm Staging; D016017:Odds Ratio; D010641:Phenotype; D062085:RNA, Long Noncoding / Q000235:genetics*; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: C000605290:BANCR long non-coding RNA, human; D014408:Biomarkers, Tumor; D062085:RNA, Long Noncoding
keywords: BANCR; biomarker; gastrointestinal cancer; long non-coding RNA; meta-analysis