title: Development of "[11C]kits" for a fast, efficient and reliable production of carbon-11 labeled radiopharmaceuticals for Positron Emission Tomography.
abstract: Translation of carbon-11 labeled PET tracers to clinical settings is currently impeded by the technical difficulties associated with [11C]CO2conversion into the highly reactive methylating agents [11C]CH3I and [11C]CH3OTf using automated modules relying on stationary valves. Here we describe development of the first in its kind "[11C]kit" for production of carbon-11 radiotracer using disposable manifolds. This method proved to be very reliable and allows for consecutive production of PET tracers with minimal intervals between the syntheses.
authors.affiliation: Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, Canada H3A2B4.
authors.forename: Dean
authors.initials: D
authors.lastname: Jolly
authors.affiliation: Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, Canada H3A2B4.
authors.forename: Robert
authors.initials: R
authors.lastname: Hopewell
authors.affiliation: Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, Canada H3A2B4.
authors.forename: Miriam
authors.initials: M
authors.lastname: Kovacevic
authors.affiliation: Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, Canada H3A2B4.
authors.forename: Qian Ying
authors.initials: QY
authors.lastname: Li
authors.affiliation: Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, Canada H3A2B4; Concordia-PERFORM Centre, Concordia University, Montreal, Canada.
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Soucy
authors.affiliation: Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, Canada H3A2B4.
authors.forename: Alexey
authors.initials: A
authors.lastname: Kostikov
mesh_terms: D001331:Automation / Q000295:instrumentation / Q000379:methods; D002250:Carbon Radioisotopes / Q000737:chemistry / Q000302:isolation & purification*; D004867:Equipment Design; D017743:Equipment Reuse; D006801:Humans; D007553:Isotope Labeling / Q000295:instrumentation / Q000379:methods*; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D002250:Carbon Radioisotopes; C000615233:Carbon-11; D019275:Radiopharmaceuticals
keywords: Automated radiolabeling; Carbon-11 radiotracers; Kit-like production; Positron Emission Tomography