title: Magnetic and fluorescent Gd2O3:Yb3+/Ln3+nanoparticles for simultaneous upconversion luminescence/MR dual modal imaging and NIR-induced photodynamic therapy.
abstract: The development of upconversion nanoparticles (UCNs) for theranostics application is a new strategy toward the accurate diagnosis and efficient treatment of cancer. Here, magnetic and fluorescent lanthanide-doped gadolinium oxide (Gd2O3) UCNs with bright upconversion luminescence (UCL) and high longitudinal relaxivity (r1) are used for simultaneous magnetic resonance imaging (MRI)/UCL dual-modal imaging and photodynamic therapy (PDT). In vitro and in vivo MRI studies show that these products can serve as good MRI contrast agents. The bright upconversion luminescence of the products allows their use as fluorescence nanoprobes for live cells imaging. We also utilized the luminescence-emission capability of the UCNs for the activation of a photosensitizer to achieve significant PDT results. To the best of our knowledge, this study is the first use of lanthanide-doped Gd2O3UCNs in a theranostics application. This investigation provides a useful platform for the development of Gd2O3-based UCNs for clinical diagnosis, treatment, and imaging-guided therapy of cancer.
authors.affiliation: School of Electronics and Information Technology and School of Physics.
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Oncology in South China, Imaging Diagnosis and Interventional Center; Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat-Sen University.
authors.forename: Long
authors.initials: L
authors.lastname: Huang
authors.affiliation: Department of Biomedical Engineering, Guangzhou Medical University.
authors.forename: Xiumei
authors.initials: X
authors.lastname: Tian
authors.affiliation: Department of Biomedical Engineering, Guangzhou Medical University.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Optoelectronic Materials and Technologies, Sun Yat-Sen University, Guangzhou, People's Republic of China.
authors.forename: Yuanzhi
authors.initials: Y
authors.lastname: Shao
authors.affiliation: Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat-Sen University.
authors.forename: Fukang
authors.initials: F
authors.lastname: Xie
authors.affiliation: School of Electronics and Information Technology and School of Physics.
authors.forename: Dihu
authors.initials: D
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Oncology in South China, Imaging Diagnosis and Interventional Center.
authors.forename: Li
authors.initials: L
authors.lastname: Li
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000737:chemistry / Q000627:therapeutic use; D005453:Fluorescence; D005682:Gadolinium / Q000737:chemistry*; D006801:Humans; D028581:Lanthanoid Series Elements / Q000737:chemistry* / Q000627:therapeutic use; D049449:Luminescence; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008807:Mice, Inbred BALB C; D053758:Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000737:chemistry / Q000627:therapeutic use; D023041:Xenograft Model Antitumor Assays / Q000379:methods; D015018:Ytterbium / Q000737:chemistry
chemical_list: D003287:Contrast Media; D028581:Lanthanoid Series Elements; D017319:Photosensitizing Agents; C030581:gadolinium oxide; D005682:Gadolinium; D015018:Ytterbium
keywords: MR imaging; photodynamic therapy; singlet oxygen; upconversion luminescence imaging; upconversion nanoparticles