title: Dissonance Strikes a Chord in Stilbene Synthesizers.
abstract: In this issue of Cell Chemical Biology, Mori et al. (2016) combine X-ray crystallography and biochemistry to discover a new mechanism for stilbene synthesis in bacteria. The dialkyl-condensing enzyme StlD catalyzes formation of cyclohexanediones using a non-canonical β-ketosynthase active site. Aromatization by StlC completes production of the stilbene product.
authors.affiliation: Department of Biology, Washington University in St. Louis, One Brookings Drive, CB1137, St. Louis, MO 63130, USA.
authors.forename: Cynthia K
authors.initials: CK
authors.lastname: Holland
authors.affiliation: Department of Biology, Washington University in St. Louis, One Brookings Drive, CB1137, St. Louis, MO 63130, USA.
authors.forename: Barbara
authors.initials: B
authors.lastname: Cascella
authors.affiliation: Department of Biology, Washington University in St. Louis, One Brookings Drive, CB1137, St. Louis, MO 63130, USA. Electronic address: jjez@wustl.edu.
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Jez