title: The small GTPase ARF6 regulates protein trafficking to control cellular function during development and in disease.
abstract: The activation of the small GTPase ARF6 has been implicated in promoting several pathological processes related to vascular instability and tumor formation, growth, and metastasis. ARF6 also plays a vital role during embryonic development. Recent studies have suggested that ARF6 carries out these disparate functions primarily by controlling protein trafficking within the cell. ARF6 helps direct proteins to intracellular or extracellular locations where they function in normal cellular responses during development and in pathological processes later in life. This transport of proteins is accomplished through a variety of mechanisms, including endocytosis and recycling, microvesicle release, and as yet uncharacterized processes. This Commentary will explore the functions of ARF6, while focusing on the role of this small GTPase in development and postnatal physiology, regulating barrier function and diseases associated with its loss, and tumor formation, growth, and metastasis.
authors.affiliation: a Department of Medicine , Program in Molecular Medicine, University of Utah , Salt Lake City , UT , USA.|b Department of Pathology , University of Utah , Salt Lake City , UT , USA.|c ARUP Laboratories, University of Utah , Salt Lake City , UT , USA.
authors.forename: Allie H
authors.initials: AH
authors.lastname: Grossmann
authors.affiliation: a Department of Medicine , Program in Molecular Medicine, University of Utah , Salt Lake City , UT , USA.
authors.forename: Helong
authors.initials: H
authors.lastname: Zhao
authors.affiliation: a Department of Medicine , Program in Molecular Medicine, University of Utah , Salt Lake City , UT , USA.
authors.forename: Noah
authors.initials: N
authors.lastname: Jenkins
authors.affiliation: a Department of Medicine , Program in Molecular Medicine, University of Utah , Salt Lake City , UT , USA.|d Department of Medicine , Division of Cardiovascular Medicine, University of Utah , Salt Lake City , UT , USA.
authors.forename: Weiquan
authors.initials: W
authors.lastname: Zhu
authors.affiliation: a Department of Medicine , Program in Molecular Medicine, University of Utah , Salt Lake City , UT , USA.|e Department of Oncological Sciences , University of Utah , Salt Lake City , UT , USA.
authors.forename: Jackson R
authors.identifier: 0000-0001-5725-7761
authors.initials: JR
authors.lastname: Richards
authors.affiliation: a Department of Medicine , Program in Molecular Medicine, University of Utah , Salt Lake City , UT , USA.|e Department of Oncological Sciences , University of Utah , Salt Lake City , UT , USA.
authors.forename: Jae Hyuk
authors.initials: JH
authors.lastname: Yoo
authors.affiliation: a Department of Medicine , Program in Molecular Medicine, University of Utah , Salt Lake City , UT , USA.
authors.forename: Jacob M
authors.initials: JM
authors.lastname: Winter
authors.affiliation: a Department of Medicine , Program in Molecular Medicine, University of Utah , Salt Lake City , UT , USA.
authors.forename: Bianca
authors.initials: B
authors.lastname: Rich
authors.affiliation: a Department of Medicine , Program in Molecular Medicine, University of Utah , Salt Lake City , UT , USA.
authors.forename: Tara M
authors.initials: TM
authors.lastname: Mleynek
authors.affiliation: a Department of Medicine , Program in Molecular Medicine, University of Utah , Salt Lake City , UT , USA.|d Department of Medicine , Division of Cardiovascular Medicine, University of Utah , Salt Lake City , UT , USA.|e Department of Oncological Sciences , University of Utah , Salt Lake City , UT , USA.|f Department of Human Genetics , University of Utah , Salt Lake City , UT , USA.|g Sichuan Provincial Key Laboratory for Human Disease Gene Study , Sichuan Provincial People's Hospital, Chinese Academy of Sciences , Chengdu , China.|h Department of Cardiology , VA Salt Lake City Health Care System , Salt Lake City , UT , USA.|i Navigen Inc. , Salt Lake City , UT , USA.
authors.forename: Dean Y
authors.initials: DY
authors.lastname: Li
authors.affiliation: a Department of Medicine , Program in Molecular Medicine, University of Utah , Salt Lake City , UT , USA.|d Department of Medicine , Division of Cardiovascular Medicine, University of Utah , Salt Lake City , UT , USA.|j Department of Neurobiology and Anatomy , University of Utah , Salt Lake City , UT , USA.
authors.forename: Shannon J
authors.initials: SJ
authors.lastname: Odelberg
mesh_terms: D000089982:ADP-Ribosylation Factor 6; D020727:ADP-Ribosylation Factors / Q000502:physiology*; D000818:Animals; D047108:Embryonic Development; D004730:Endothelium, Vascular / Q000502:physiology; D006801:Humans; D009369:Neoplasms / Q000201:enzymology / Q000473:pathology; D021381:Protein Transport
chemical_list: D000089982:ADP-Ribosylation Factor 6; D020727:ADP-Ribosylation Factors; C000715348:ARF6 protein, human
keywords: ARF6, barrier function; adenosine diphosphate ribosylation factor 6; cancer; development; metastasis; postnatal physiology; protein trafficking; tumor growth; vascular stability