title: mMRI at 3.0 T as an Evaluation Tool of Therapeutic Response to Neoadjuvant CRT in Patients with Advanced-stage Rectal Cancer.
abstract: To assess whether multiparametric MRI (mMRI) can serve as a tool for evaluating response to chemoradiation therapy (CRT) in advanced-stage rectal cancer.
  
  
  
  Twenty-one patients underwent a mMRI protocol at 3T before and after CRT. Two experienced radiologists evaluated the MRI measurements and inter-reader correlation was assessed. Changes in functional parameters in relation to regression, as well as pT stage were analyzed. The perfusion parameters plasma flow (PF) and mean transit time (MTT) were calculated offline using the established UMM Perfusion tool.
  
  
  
  Apparent diffusion coefficient values were significantly different among the different tumor RGs before CRT (p=0.041). Changes of dynamic contrast enhanced (DCE) MRI values did not reflect treatment response (PF: p=0.5; MTT: p=0.74).
  
  
  
  The results of our study population indicate that a high initial apparent diffusion coefficient value may be predictive of response to therapy following CRT.
authors.affiliation: Institute of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
authors.forename: Ulrike I
authors.initials: UI
authors.lastname: Attenberger
authors.affiliation: Institute of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
authors.forename: Melissa M
authors.initials: MM
authors.lastname: Ong
authors.affiliation: Institute of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
authors.forename: Nils
authors.initials: N
authors.lastname: Rathmann
authors.affiliation: Department of Surgery, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
authors.forename: Fabian
authors.initials: F
authors.lastname: Doyon
authors.affiliation: Department of Surgery, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Kienle
authors.affiliation: Department of Oncology, University Medical Center Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
authors.forename: Ralf-Dieter
authors.initials: RD
authors.lastname: Hofheinz
authors.affiliation: Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
authors.forename: Lothar R
authors.initials: LR
authors.lastname: Pilz
authors.affiliation: Institute of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
authors.forename: Dietmar J
authors.initials: DJ
authors.lastname: Dinter
authors.affiliation: Institute of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
authors.forename: Stefan O
authors.initials: SO
authors.lastname: Schoenberg
authors.affiliation: Institute of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany daniel.hausmann@medma.uni-heidelberg.de.
authors.forename: Daniel
authors.initials: D
authors.lastname: Hausmann
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging* / Q000473:pathology / Q000628:therapy*; D000368:Aged; D059248:Chemoradiotherapy; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D012004:Rectal Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000628:therapy*; D016896:Treatment Outcome
keywords: Multi-parametric MRI; apparent diffusion coefficient; dynamic contrast enhancement; rectal cancer