title: Toward a better understanding on the role of prediction error on memory processes: From bench to clinic.
abstract: Experimental psychology defines Prediction Error (PE) as a mismatch between expected and current events. It represents a unifier concept within the memory field, as it is the driving force of memory acquisition and updating. Prediction error induces updating of consolidated memories in strength or content by memory reconsolidation. This process has two different neurobiological phases, which involves the destabilization (labilization) of a consolidated memory followed by its restabilization. The aim of this work is to emphasize the functional role of PE on the neurobiology of learning and memory, integrating and discussing different research areas: behavioral, neurobiological, computational and clinical psychiatry.
authors.affiliation: Laboratorio de Neurofarmacología de los Procesos de Memoria, Cátedra de Farmacología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956, 5(to)piso, Buenos Aires, Argentina. Electronic address: mc.krawczyk1985@gmail.com.
authors.forename: María C
authors.initials: MC
authors.lastname: Krawczyk
authors.affiliation: Laboratorio de Neurobiología de la Memoria, Departamento de Fisiología y Biología Molecular y Celular, IFIBYNE-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina. Pab. II, 2(do)piso, Buenos Aires, Argentina. Electronic address: rodrigofernandez@fbmc.fcen.uba.ar.
authors.forename: Rodrigo S
authors.initials: RS
authors.lastname: Fernández
authors.affiliation: Laboratorio de Neurobiología de la Memoria, Departamento de Fisiología y Biología Molecular y Celular, IFIBYNE-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina. Pab. II, 2(do)piso, Buenos Aires, Argentina. Electronic address: mpedreira@fbmc.fcen.uba.ar.
authors.forename: María E
authors.initials: ME
authors.lastname: Pedreira
authors.affiliation: Laboratorio de Neurofarmacología de los Procesos de Memoria, Cátedra de Farmacología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956, 5(to)piso, Buenos Aires, Argentina. Electronic address: mboccia@ffyb.uba.ar.
authors.forename: Mariano M
authors.initials: MM
authors.lastname: Boccia
mesh_terms: D000818:Animals; D006801:Humans; D007858:Learning / Q000502:physiology*; D008568:Memory / Q000502:physiology*; D000069077:Memory Consolidation / Q000502:physiology*; D001523:Mental Disorders / Q000523:psychology
keywords: Accommodation; Anxiety disorders; Assimilation; Destabilization; Psychiatry; Schizophrenia