title: Serum Progranulin Levels in Type 2 Diabetic Patients with Metabolic Syndrome.
abstract: BACKGROUND
  The role of progranulin in individuals with metabolic syndrome is not exactly clear.We aimed to assess the serum level of progranulin in type 2 diabetic patients with and without metabolic syndrome and compare them with healthy controls.
  
  
  METHODS
  The study included 60 patients with type 2 diabetes and 30 healthy individuals as control groups. Biochemical parameters and progranulin levels were determined.
  
  
  RESULTS
  Subjects with metabolic syndrome showed significantly higher levels of triglyceride, waist circumference, BMI, systolic and diastolic blood pressure than subjects without metabolic syndrome and the control groups, while HDL-cholesterol level was significantly lower in subjects with metabolic syndrome. Fasting blood sugar was significantly higher in type 2 diabetic patients than in the control groups. Serum level of progranulin was slightly increased in subjects with metabolic syndrome. Serum progranulin level had no significant relationship with metabolic syndrome components.
  
  
  CONCLUSIONS
  Serum progranulin was also not dependent on cardiometabolic risk factors for subjects with metabolic syndrome, but it could be considered for the management of type 2 diabetes mellitus. Further studies are recommended to explain the effect of progranulin on the pathogenesis of metabolic risk factors.
authors.forename: Azam
authors.initials: A
authors.lastname: Shafaei
authors.forename: Abdoljalal
authors.initials: A
authors.lastname: Marjani
authors.forename: Masoud
authors.initials: M
authors.lastname: Khoshnia
mesh_terms: D000328:Adult; D001786:Blood Glucose; D001794:Blood Pressure; D015992:Body Mass Index; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D007492:Iran; D008055:Lipids / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000150:complications; D008875:Middle Aged; D000077153:Progranulins
chemical_list: D001786:Blood Glucose; C492314:GRN protein, human; D036341:Intercellular Signaling Peptides and Proteins; D008055:Lipids; D000077153:Progranulins