title: Alpinumisoflavone induces apoptosis in esophageal squamous cell carcinoma by modulating miR-370/PIM1 signaling.
abstract: Esophageal squamous cell carcinoma (ESCC) is the most prevalent type of esophageal cancer and accumulating evidence has confirmed the role of miRNAs in ESCC. One such miRNA, miR-370, was found to be aberrantly downregulated in various human malignancies. This study showed that the expression of miR-370 was significantly lower in ESCC tissues and cell lines, and miR-370 functioned as a tumor suppressor in ESCC. Moreover, this is the first report that showed miR-370 suppresses cell proliferation and tumor growth by directly targeting Pim family kinases 1 (PIM1). Furthermore, alpinumisoflavone, a naturally occurring flavonoid, could inhibit tumor growth of ESCC by targeting miR-370/PIM1 signaling.
authors.affiliation: Qingdao University Qingdao 266071, Shandong, China.
authors.forename: Yantao
authors.initials: Y
authors.lastname: Han
authors.affiliation: Qingdao University Affiliated Hospital Qingdao 266071, Shandong, China.
authors.forename: Xiuwei
authors.initials: X
authors.lastname: Yang
authors.affiliation: Qingdao University Affiliated Hospital Qingdao 266071, Shandong, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Zhao
authors.affiliation: College of Life Sciences, Chongqing Normal University Chongqing 401331, China.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Peng
authors.affiliation: Qingdao University Qingdao 266071, Shandong, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Gao
authors.affiliation: 92196 Military Hospital Qingdao 266011, Shandong, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Qiu
keywords: ESCC; PIM1; alpinumisoflavone; miR-370