title: Multifunctional near-infrared dye-magnetic nanoparticles for bioimaging and cancer therapy.
abstract: Theranostics based on nanoparticles have developed rapidly in the past decade and have been widely used in the diagnosis and treatment of liver cancer, breast cancer, and other tumors. However, for skin cancers, there are limited studies. In the present study, we successfully synthesized a theranostic nanoparticle by grating IR820 onto the surface of chitosan-coated magnetic iron oxide, IR820-CS-Fe3O4, showing an excellent magnetic resonance imaging (MRI) capability and cytotoxic effects against melanoma under irradiation with a near-infrared (NIR) laser (808 nm) in vitro. Furthermore, good stability for up to 8 days and negligible cytotoxicity were observed. These characteristics are important for biomedical applications of nanoparticles. In conclusion, we provide a novel and potential theranostic platform for melanoma treatment and detection.
authors.affiliation: Department of Dermatology, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, China.
authors.forename: Xiaoyang
authors.initials: X
authors.lastname: Hou
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Centre for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, China.
authors.forename: Huige
authors.initials: H
authors.lastname: Zhou
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Centre for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, China.
authors.forename: Liming
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Dermatology, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, China.
authors.forename: Jianqin
authors.initials: J
authors.lastname: Tang
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Centre for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, China. Electronic address: chenchy@nanoctr.cn.
authors.forename: Chunying
authors.initials: C
authors.lastname: Chen
authors.affiliation: Department of Dermatology, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, China. Electronic address: dr.guanjiang@gmail.com.
authors.forename: Guan
authors.initials: G
authors.lastname: Jiang
authors.affiliation: Department of Dermatology, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, China.
authors.forename: Yanqun
authors.initials: Y
authors.lastname: Liu
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000528:radiation effects; D003287:Contrast Media / Q000737:chemistry; D005434:Flow Cytometry; D006358:Hot Temperature; D006801:Humans; D007208:Indocyanine Green / Q000031:analogs & derivatives / Q000737:chemistry; D007259:Infrared Rays; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use*; D008545:Melanoma / Q000628:therapy*; D046529:Microscopy, Electron, Transmission
chemical_list: D003287:Contrast Media; C541053:IR 820; D058185:Magnetite Nanoparticles; D007208:Indocyanine Green
keywords: Magnetic resonance imaging (MRI); Melanoma; Nanoparticles; Phototherapy; Theranostics