title: Being "penny-wise but pound foolish" in cancer immunotherapy research: the urgent need for mouse cancer models to reflect human modifying factors.
abstract: Inbred mice are the mainstay for preclinical cancer assessment of potential therapeutics, especially immune-based approaches. However, the use of young, lean, inbred mice housed under specific-pathogen-free conditions does not mirror the human cancer scenario. This commentary discusses some of the issues in evaluating immunotherapeutics in mice given recent advances.
authors.affiliation: Departments of Dermatology and Internal Medicine, UC Davis School of Medicine, Sacramento, CA USA.
authors.forename: William J
authors.initials: WJ
authors.lastname: Murphy