title: Reduced islet function contributes to impaired glucose homeostasis in fructose-fed mice.
abstract: Increased sugar consumption, particularly fructose, in the form of sweetened beverages and sweeteners in our diet adversely affects metabolic health. Because these effects are associated with features of the metabolic syndrome in humans, the direct effect of fructose on pancreatic islet function is unknown. Therefore, we examined the islet phenotype of mice fed excess fructose. Fructose-fed mice exhibited fasting hyperglycemia and glucose intolerance but not hyperinsulinemia, dyslipidemia, or hyperuricemia. Islet function was impaired, with decreased glucose-stimulated insulin secretion and increased glucagon secretion and high fructose consumption leading to α-cell proliferation and upregulation of the fructose transporter GLUT5, which was localized only in α-cells. Our studies demonstrate that excess fructose consumption contributes to hyperglycemia by affecting both β- and α-cells of islets in mice.
authors.affiliation: Department of Obstetrics and Gynecology, Washington University in St. Louis School of Medicine, St. Louis, Missouri; and.
authors.forename: Zeenat A
authors.initials: ZA
authors.lastname: Asghar
authors.affiliation: Department of Obstetrics and Gynecology, Washington University in St. Louis School of Medicine, St. Louis, Missouri; and.
authors.forename: Andrew
authors.initials: A
authors.lastname: Cusumano
authors.affiliation: Department of Medicine, Washington University in St. Louis School of Medicine, St. Louis, Missouri.
authors.forename: Zihan
authors.initials: Z
authors.lastname: Yan
authors.affiliation: Department of Medicine, Washington University in St. Louis School of Medicine, St. Louis, Missouri.
authors.forename: Maria S
authors.initials: MS
authors.lastname: Remedi
authors.affiliation: Department of Obstetrics and Gynecology, Washington University in St. Louis School of Medicine, St. Louis, Missouri; and moleyk@wudosis.wustl.edu.
authors.forename: Kelle H
authors.initials: KH
authors.lastname: Moley
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D004040:Dietary Carbohydrates / Q000494:pharmacology; D015536:Down-Regulation / Q000187:drug effects; D005632:Fructose / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism*; D018149:Glucose Intolerance / Q000378:metabolism; D006706:Homeostasis / Q000187:drug effects*; D007515:Islets of Langerhans / Q000187:drug effects* / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL
chemical_list: D004040:Dietary Carbohydrates; D005632:Fructose; D005947:Glucose