title: Depression and Hypothyroidism in a Population-Based Study of Iranian Women.
abstract: BACKGROUND
  Recent biochemical and physiological investigations have focused on the fundament of mood disorders in thyroid dysfunction. The present study aimed to address depressive disorder in a sample of Iranian hypothyroid women compared to euthyroid individuals.
  
  
  METHODS
  Thirty consecutive hypothyroid female patients aged 25 to 40 years who referred to the Endocrinology and Metabolism Clinic at Rasoul-e-Akram Hospital in Tehran within a four-month period in 2015 were assessed. Thirty healthy euthyroid subjects matched for sex, age, and educational level were selected as the control. For assessment of depression status, Depression Anxiety Stress Scale-21 (DASS-21) was employed.
  
  
  RESULTS
  The study showed higher mean depression score in hypothyroid patients when compared to euthyroid ones (13.8 ± 9.5 versus 5.8 ± 5.2, p = 0.010). No significant association was revealed between mean depression score and patients' education level (p = 0.627), age (p = 0.967), occupation status (p = 0.211), and marital status (p = 0.556).
  
  
  CONCLUSIONS
  Hypothyroid women are predisposed to depressive symptoms independent of their baseline demographic and socioeconomic characteristics.
authors.forename: Abbas Tavalaei
authors.initials: AT
authors.lastname: Zavareh
authors.forename: Rohollah
authors.initials: R
authors.lastname: Jomhouri
authors.forename: Hadi Shahrad
authors.initials: HS
authors.lastname: Bejestani
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Arshad
authors.forename: Mohammadali
authors.initials: M
authors.lastname: Daneshmand
authors.forename: Hossein
authors.initials: H
authors.lastname: Ziaei
authors.forename: Neda
authors.initials: N
authors.lastname: Babadi
authors.forename: Marzieh
authors.initials: M
authors.lastname: Amiri
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003866:Depressive Disorder / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000523:psychology*; D007492:Iran; D012737:Sex Factors; D012959:Socioeconomic Factors