title: L1 retrotransposition alters the hippocampal genomic landscape enabling memory formation.
abstract: Somatic LINE-1 (L1) retrotransposition is a source of genomic mosaicism and potential phenotypic diversity among neurons during brain development. In the adult brain, L1 expression can be triggered by different environmental alterations, but its functional role in this context remains unknown. Here we demonstrate a neural activation-dependent increase in the number of L1 retrotransposon insertions in the hippocampus. Using both pharmacologic and genetic approaches in mice, we demonstrate that L1 expression in the adult hippocampus enables long-term memory formation. These results provide experimental evidence that L1 retrotransposition-induced genomic mosaicism is involved in cognitive processes such as memory formation.
authors.affiliation: División de Neurociencias, Departamento de Fisiología, Anatomía y Biología Celular, Universidad Pablo de Olavide, Carretera de Utrera Km 1, 41013 Sevilla, Spain.
authors.forename: Sara
authors.initials: S
authors.lastname: Bachiller
authors.affiliation: División de Neurociencias, Departamento de Fisiología, Anatomía y Biología Celular, Universidad Pablo de Olavide, Carretera de Utrera Km 1, 41013 Sevilla, Spain.
authors.forename: Yaiza
authors.initials: Y
authors.lastname: Del-Pozo-Martín
authors.affiliation: División de Neurociencias, Departamento de Fisiología, Anatomía y Biología Celular, Universidad Pablo de Olavide, Carretera de Utrera Km 1, 41013 Sevilla, Spain. Electronic address: amancar@upo.es.
authors.forename: Ángel Manuel
authors.initials: ÁM
authors.lastname: Carrión
mesh_terms: D000818:Animals; D023281:Genomics; D006624:Hippocampus / Q000378:metabolism*; D020084:Long Interspersed Nucleotide Elements; D008297:Male; D057567:Memory, Long-Term; D051379:Mice; D009030:Mosaicism; D018626:Retroelements
chemical_list: D018626:Retroelements
keywords: Gene expression; Hippocampus; LINE1; Memory formation; Retrotransposition