title: Analytical and clinical comparison of Elecsys syphilis (Roche®) - Architect syphilis TP and reformulated Architect syphilis TP (Abbott®) assay.
abstract: The performance of Elecsys Syphilis was compared to Architect Syphilis TP and Reformulated Architect Syphilis TP. The overall sensitivity and specificity were 98.4% and 99.5%, 97.7% and 97.1%, and 99.2% and 99.7% respectively. The assays are comparable and considered adequate for syphilis screening.
authors.affiliation: Department of Laboratory Medicine, AZ Alma, Eeklo, Belgium.
authors.forename: Steven
authors.initials: S
authors.lastname: De Keukeleire
authors.affiliation: Department of Microbiology and Immunology, University Hospitals Leuven, Leuven, Belgium.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Desmet
authors.affiliation: Department of Microbiology and Immunology, University Hospitals Leuven, Leuven, Belgium.
authors.forename: Katrien
authors.initials: K
authors.lastname: Lagrou
authors.affiliation: Department of Microbiology and Immunology, University Hospitals Leuven, Leuven, Belgium.
authors.forename: Julie
authors.initials: J
authors.lastname: Oosterlynck
authors.affiliation: Department of Laboratory Medicine, AZ St Jan Bruges, Bruges, Belgium.
authors.forename: Manon
authors.initials: M
authors.lastname: Verhulst
authors.affiliation: Department of Laboratory Medicine, AZ St Jan Bruges, Bruges, Belgium.
authors.forename: Jessica
authors.initials: J
authors.lastname: Van Besien
authors.affiliation: Department of Microbiology and Immunology, University Hospitals Leuven, Leuven, Belgium.
authors.forename: Veroniek
authors.initials: V
authors.lastname: Saegeman
authors.affiliation: Department of Laboratory Medicine, AZ St Jan Bruges, Bruges, Belgium. Electronic address: marijke.reynders@azsintjan.be.
authors.forename: Marijke
authors.initials: M
authors.lastname: Reynders
mesh_terms: D001431:Bacteriological Techniques / Q000379:methods; D001681:Biological Assay; D006386:Hemagglutination Tests / Q000379:methods*; D006801:Humans; D007118:Immunoassay / Q000379:methods*; D016133:Polymerase Chain Reaction / Q000379:methods*; D011933:Reagent Kits, Diagnostic; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013587:Syphilis / Q000175:diagnosis*; D014210:Treponema pallidum / Q000276:immunology*
chemical_list: D011933:Reagent Kits, Diagnostic
keywords: Architect syphilis TP assay; EIA; Elecsys syphilis assay; Reformulated architect syphilis TP assay; Sensitivity; Specificity; Syphilis