title: Robotic assisted laparoscopic radical prostatectomy following transrectal compared to transperineal prostate biopsy: surgical, oncological and functional outcomes.
abstract: To assess if transperineal prostate (TP) biopsy affects th e outcome of robotic-assisted laparoscopic prostatectomy (RALP), with particular reference to perioperative complications, oncological results and functional outcomes in the early postoperative setting.
  
  
  
  We identified 61 men who had undergone RALP after TP biopsies, from June 2012 to June 2014 and a control group of 120 men who had undergone RALP after conventional TRUS biopsy in the same period. Data was compared from the pre-operative biopsy, peri- and postoperative period, procedural outcomes including histological, oncological and functional outcomes between the groups.
  
  
  
  The groups had comparable demographics, with matched median ages and PSA levels. There was a higher incidence of Gleason 6 disease detected in the TRUS group (P=0.01). Mean operative time (146 minutes TRUS vs. 158 minutes TP, P=0.133), blood loss (250 mL TRUS vs. 288 mL TP, P=0.462) and intraoperative complications were not significantly different between groups. Median length of stay (1 day) and median catheter duration (7 days) were identical in both cohorts. PSA failure rate at 6 months was similar (11.7% TRUS vs. 9.8% TP, P=0.904). There were no differences in functional outcomes (potency or continence) between groups at 6 month s follow-up.
  
  
  
  RALP is safe after TP biopsy with no adverse impact on oncological or short-term functional outcomes.
authors.affiliation: CamPARI Clinic, Addenbrookes Hospital and University of Cambridge, Cambridge, UK - Kwadhwa@doctors.org.uk.|Department of Urology, Addenbrooke's Hospital, Cambridge, UK - Kwadhwa@doctors.org.uk.
authors.forename: Karan
authors.initials: K
authors.lastname: Wadhwa
authors.affiliation: Department of Urology, Addenbrooke's Hospital, Cambridge, UK.
authors.forename: Giulio
authors.initials: G
authors.lastname: Patruno
authors.affiliation: Department of Radiology, Addenbrooke's Hospital and University of Cambridge, Cambridge, UK.
authors.forename: Andrew
authors.initials: A
authors.lastname: Patterson
authors.affiliation: CamPARI Clinic, Addenbrookes Hospital and University of Cambridge, Cambridge, UK.|Department of Radiology, Addenbrooke's Hospital and University of Cambridge, Cambridge, UK.
authors.forename: Tristan
authors.initials: T
authors.lastname: Barrett
authors.affiliation: Department of Urology, Addenbrooke's Hospital, Cambridge, UK.
authors.forename: Chandni
authors.initials: C
authors.lastname: Dalia
authors.affiliation: Department of Radiology, Addenbrooke's Hospital and University of Cambridge, Cambridge, UK.
authors.forename: Brendan C
authors.initials: BC
authors.lastname: Koo
authors.affiliation: Department of Radiology, Addenbrooke's Hospital and University of Cambridge, Cambridge, UK.
authors.forename: Ferdia A
authors.initials: FA
authors.lastname: Gallagher
authors.affiliation: Department of Radiology, Addenbrooke's Hospital and University of Cambridge, Cambridge, UK.
authors.forename: Eva
authors.initials: E
authors.lastname: Serrao
authors.affiliation: Department of Histopathology, Addenbrooke's Hospital and University of Cambridge, Cambridge, UK.
authors.forename: Anne
authors.initials: A
authors.lastname: Warren
authors.affiliation: CamPARI Clinic, Addenbrookes Hospital and University of Cambridge, Cambridge, UK.|Department of Urology, Addenbrooke's Hospital, Cambridge, UK.
authors.forename: Vincent
authors.initials: V
authors.lastname: Gnanapragasam
authors.affiliation: CamPARI Clinic, Addenbrookes Hospital and University of Cambridge, Cambridge, UK.|Department of Urology, Addenbrooke's Hospital, Cambridge, UK.
authors.forename: Nimish
authors.initials: N
authors.lastname: Shah
authors.affiliation: CamPARI Clinic, Addenbrookes Hospital and University of Cambridge, Cambridge, UK.|Department of Urology, Addenbrooke's Hospital, Cambridge, UK.
authors.forename: Andrew
authors.initials: A
authors.lastname: Doble
authors.affiliation: CamPARI Clinic, Addenbrookes Hospital and University of Cambridge, Cambridge, UK.|Department of Urology, Addenbrooke's Hospital, Cambridge, UK.
authors.forename: Christof
authors.initials: C
authors.lastname: Kastner
mesh_terms: D000368:Aged; D001706:Biopsy / Q000379:methods; D006801:Humans; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D011468:Prostatectomy / Q000379:methods*; D011471:Prostatic Neoplasms / Q000601:surgery*; D020127:Recovery of Function; D065287:Robotic Surgical Procedures; D016896:Treatment Outcome