title: Copy number alterations unmasked as enhancer hijackers.
abstract: Our understanding of how DNA copy number changes contribute to disease, including cancer, has to a large degree been focused on the changes in gene dosage that they generate and has neglected the effects of the DNA rearrangements that lead to their formation. A new study reports an innovative analytical framework for copy number alterations that are oncogenic primarily owing to the genomic rearrangements that underlie them.
authors.affiliation: Dana-Farber Cancer Institute, the Broad Institute of Harvard and MIT, and Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Rameen
authors.initials: R
authors.lastname: Beroukhim
authors.affiliation: Dana-Farber Cancer Institute, the Broad Institute of Harvard and MIT, and Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Xiaoyang
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Dana-Farber Cancer Institute, the Broad Institute of Harvard and MIT, and Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Matthew
authors.identifier: 0000-0002-9133-8108
authors.initials: M
authors.lastname: Meyerson
mesh_terms: D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics / Q000378:metabolism; D002869:Chromosome Aberrations; D002883:Chromosomes, Human, Pair 14; D002896:Chromosomes, Human, Pair 6; D002898:Chromosomes, Human, Pair 8; D056915:DNA Copy Number Variations; D004742:Enhancer Elements, Genetic; D050989:GATA2 Transcription Factor / Q000235:genetics / Q000378:metabolism; D018628:Gene Dosage; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007335:Insulin-Like Growth Factor II / Q000235:genetics / Q000378:metabolism; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics / Q000378:metabolism; D000073942:T-Cell Acute Lymphocytic Leukemia Protein 1
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D050989:GATA2 Transcription Factor; D007335:Insulin-Like Growth Factor II; D011518:Proto-Oncogene Proteins; D016271:Proto-Oncogene Proteins c-myc; D000073942:T-Cell Acute Lymphocytic Leukemia Protein 1; C494711:GATA2 protein, human; C035170:IGF2 protein, human; C489427:MYC protein, human; C067143:TAL1 protein, human