title: Association of anti-aminoacyl-transfer RNA synthetase antibody and anti-melanoma differentiation-associated gene 5 antibody with the therapeutic response of polymyositis/dermatomyositis-associated interstitial lung disease.
abstract: BACKGROUND
  We attempted to clarify whether the presence of anti-aminoacyl-transfer RNA synthetase antibody (anti-ARS Ab) or anti-melanoma differentiation-associated gene 5 antibody (anti-MDA5 Ab) is associated with the therapeutic response of polymyositis/dermatomyositis-associated interstitial lung disease (PM/DM-ILD).
  
  
  METHODS
  We retrospectively investigated 22 patients with PM/DM-ILD (10 positive for anti-ARS Ab and nine positive for anti-MDA5 Ab) for whom antibody analysis of conserved serum was possible. We assessed mortality in the first three months as the therapeutic response in the acute phase and compared changes in clinical data for up to one year considered as the chronic phase. We classified the clinical changes over the year into three groups: Improvement (increased % vital capacity [%VC] or diffusing capacity of the lung for carbon monoxide [%DLCO]≥10 or 15%), deterioration (decreased %VC or %DLCO≥10 or 15%), and no change (remainder of the changes). The extent of abnormality demonstrated by high-resolution computed tomography (HRCT) was scored.
  
  
  RESULTS
  Positivity for anti-MDA5 Ab, but not for anti-ARS Ab, was associated with mortality in the first 3 months. Evaluation of the therapeutic response in the first year showed that positivity for the anti-ARS Ab, but not for the anti-MDA5 Ab, was associated with an improvement in %DLCOand a decline in the serum KL-6 levels. Positivity for the anti-ARS Ab or negativity for anti-MDA5 Ab was associated with a greater decrease in bronchial dilatation as seen by HRCT.
  
  
  CONCLUSIONS
  Anti-ARS and anti-MDA5 Abs are associated with the therapeutic response of PM/DM-ILD.
authors.affiliation: Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Asahi-machi 77, Kurume, Fukuoka 830-0011, Japan. Electronic address: qu_up_fl_o_wer@yahoo.co.jp.
authors.forename: Naomi
authors.initials: N
authors.lastname: Yoshida
authors.affiliation: Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Asahi-machi 77, Kurume, Fukuoka 830-0011, Japan. Electronic address: okamoto_masaki@med.kurume-u.ac.jp.
authors.forename: Masaki
authors.initials: M
authors.lastname: Okamoto
authors.affiliation: Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Asahi-machi 77, Kurume, Fukuoka 830-0011, Japan. Electronic address: kaieda@med.kurume-u.ac.jp.
authors.forename: Shinjiro
authors.initials: S
authors.lastname: Kaieda
authors.affiliation: Department of Radiology and Center for Diagnostic Imaging, Kurume University School of Medicine, Asahi-machi 77, Kurume, Fukuoka 830-0011, Japan. Electronic address: kimichan@med.kurume-u.ac.jp.
authors.forename: Kiminori
authors.initials: K
authors.lastname: Fujimoto
authors.affiliation: Department of Radiology and Center for Diagnostic Imaging, Kurume University School of Medicine, Asahi-machi 77, Kurume, Fukuoka 830-0011, Japan. Electronic address: ebata_tomohiro@med.kurume-u.ac.jp.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Ebata
authors.affiliation: Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Asahi-machi 77, Kurume, Fukuoka 830-0011, Japan. Electronic address: motajiri@med.kurume-u.ac.jp.
authors.forename: Morihiro
authors.initials: M
authors.lastname: Tajiri
authors.affiliation: Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Asahi-machi 77, Kurume, Fukuoka 830-0011, Japan. Electronic address: nakamura@med.kurume-u.ac.jp.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Nakamura
authors.affiliation: Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Asahi-machi 77, Kurume, Fukuoka 830-0011, Japan. Electronic address: tominaga_masaki@med.kurume-u.ac.jp.
authors.forename: Masaki
authors.initials: M
authors.lastname: Tominaga
authors.affiliation: Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Asahi-machi 77, Kurume, Fukuoka 830-0011, Japan. Electronic address: wakasugi_daisuke@kurume-u.ac.jp.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Wakasugi
authors.affiliation: Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Asahi-machi 77, Kurume, Fukuoka 830-0011, Japan. Electronic address: kawayama_tomotaka@med.kurume-u.ac.jp.
authors.forename: Tomotaka
authors.initials: T
authors.lastname: Kawayama
authors.affiliation: Department of Rheumatology and Clinical Immunology, Nippon Medical School, Sendagi 1-1-5, Bunkyo-ku, Tokyo 113-0022, Japan. Electronic address: kuwanam@nms.ac.jp.
authors.forename: Masataka
authors.initials: M
authors.lastname: Kuwana
authors.affiliation: Department of Rheumatology and Clinical Immunology, Kyoto University, Yoshidahon-machi, Sakyo-ku, Kyoto 606-8501, Japan. Electronic address: mimorit@kuhp.kyoto-u.ac.jp.
authors.forename: Tsuneyo
authors.initials: T
authors.lastname: Mimori
authors.affiliation: Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Asahi-machi 77, Kurume, Fukuoka 830-0011, Japan. Electronic address: ida@med.kurume-u.ac.jp.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Ida
authors.affiliation: Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Asahi-machi 77, Kurume, Fukuoka 830-0011, Japan. Electronic address: hoshino@med.kurume-u.ac.jp.
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Hoshino
mesh_terms: D000604:Amino Acyl-tRNA Synthetases / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood*; D003882:Dermatomyositis / Q000150:complications* / Q000276:immunology*; D005260:Female; D006801:Humans; D000072640:Interferon-Induced Helicase, IFIH1 / Q000276:immunology*; D017563:Lung Diseases, Interstitial / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D001323:Autoantibodies; D000072640:Interferon-Induced Helicase, IFIH1; D000604:Amino Acyl-tRNA Synthetases
keywords: Amyopathic dermatomyositis; Anti-aminoacyl-transfer RNA synthetase antibody; Anti-melanoma differentiation-associated gene 5 antibody; Interstitial lung disease; Polymyositis/dermatomyositis