title: Case Series Description and Genomic Characterization of Invasive Group A Streptococcal Infections in Pediatric Patients.
abstract: We report an unusual cluster of invasive group A Streptococcus infections in 6 pediatric patients and demonstrate that the strains were derived from diverse genetic backgrounds, confirming the occurrence of a community cluster rather than a clonal outbreak. Whole genome sequencing provided a rapid and comprehensive view of group A Streptococcus genotypes and helped guide our institutional response and public health maneuvers.
authors.affiliation: From the *Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, California; †Keck School of Medicine at the University of Southern California, Los Angeles, California; ‡Division of Infectious Diseases, Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, California; §Center for Molecular and Translational Human Infectious Diseases Research; and ¶Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Dien Bard
authors.forename: Kanokporn
authors.initials: K
authors.lastname: Mongkolrattanothai
authors.forename: Priyanka
authors.initials: P
authors.lastname: Kachroo
authors.forename: Stephen
authors.initials: S
authors.lastname: Beres
authors.forename: Randall J
authors.initials: RJ
authors.lastname: Olsen
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D016470:Bacteremia / Q000382:microbiology*; D002648:Child; D002675:Child, Preschool; D004269:DNA, Bacterial / Q000032:analysis* / Q000235:genetics; D005260:Female; D016680:Genome, Bacterial / Q000235:genetics*; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D017422:Sequence Analysis, DNA; D013290:Streptococcal Infections / Q000382:microbiology*; D013297:Streptococcus pyogenes / Q000187:drug effects / Q000235:genetics* / Q000472:pathogenicity
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial