title: The Emerging Zika Virus Threat: A Guide for Dermatologists.
abstract: We provide a guide for dermatologists to follow if they encounter patients with a rash and clinical history suspicious of Zika virus infection, including diagnostic testing and management options. We also provide an illustrative case report of a patient from Brazil who was diagnosed with Zika virus infection after presenting with a generalized pruritic rash. One of the most prominent symptoms of Zika virus infection is a cutaneous eruption. As such, it is especially necessary for dermatologists to understand this virus so that they may appropriately recognize this entity as a diagnostic consideration in the clinic. The rash associated with Zika virus infection is most commonly an erythematous maculopapular eruption that presents after an initial 3-4 days of fever, headache, and arthralgia or myalgia. The rash typically lasts for an average of 6 days, and can spread to involve any part of the body, including the face, torso, extremities, palms, and soles.
authors.affiliation: Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. ahe1@jhmi.edu.
authors.forename: Alice
authors.identifier: http://orcid.org/0000-0002-1938-0619
authors.initials: A
authors.lastname: He
authors.affiliation: Acute Febrile Illnesses Laboratory, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil.
authors.forename: Patrícia
authors.initials: P
authors.lastname: Brasil
authors.affiliation: Acute Febrile Illnesses Laboratory, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil.
authors.forename: Andre M
authors.initials: AM
authors.lastname: Siqueira
authors.affiliation: Acute Febrile Illnesses Laboratory, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil.
authors.forename: Guilherme A
authors.initials: GA
authors.lastname: Calvet
authors.affiliation: Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Shawn G
authors.initials: SG
authors.lastname: Kwatra
mesh_terms: D000082:Acetaminophen / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001938:Brazil; D021821:Communicable Diseases, Emerging / Q000150:complications / Q000473:pathology* / Q000628:therapy*; D000072085:Dermatologists; D004196:Disease Outbreaks; D005076:Exanthema / Q000473:pathology* / Q000628:therapy* / Q000821:virology; D005440:Fluid Therapy; D006633:Histamine Antagonists / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D017410:Practice Guidelines as Topic; D011537:Pruritus / Q000473:pathology* / Q000628:therapy* / Q000821:virology; D012367:RNA, Viral / Q000302:isolation & purification; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014481:United States; D000071244:Zika Virus / Q000302:isolation & purification*; D000071243:Zika Virus Infection / Q000150:complications / Q000473:pathology* / Q000628:therapy*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D006633:Histamine Antagonists; D012367:RNA, Viral; D000082:Acetaminophen