title: A Tri-Leaflet Nitinol Mesh Scaffold for Engineering Heart Valves.
abstract: The epidemiology of valvular heart disease has significantly changed in the past few decades with aging as one of the main contributing factors. The available options for replacement of diseased valves are currently limited to mechanical and bioprosthetic valves, while the tissue engineered ones that are under study are currently far from clinical approval. The main problem with the tissue engineered heart valves is their progressive deterioration that leads to regurgitation and/or leaflet thickening a few months after implantation. The use of bioresorbable scaffolds is speculated to be one factor affecting these valves' failure. We have previously developed a non-degradable superelastic nitinol mesh scaffold concept that can be used for heart valve tissue engineering applications. It is hypothesized that the use of a non-degradable superelastic nitinol mesh may increase the durability of tissue engineered heart valves, avoid their shrinkage, and accordingly prevent regurgitation. The current work aims to study the effects of the design features on mechanical characteristics of this valve scaffold to attain proper function prior to in vivo implantation.
authors.affiliation: The Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California, Irvine, 2400 Engineering Hall, Irvine, CA, 92697-2730, USA.|Department of Biomedical Engineering, University of California, Irvine, 3120 Natural Sciences II, Irvine, CA, 92697-2715, USA.
authors.forename: S Hamed
authors.initials: SH
authors.lastname: Alavi
authors.affiliation: Department of Mechanical and Aerospace Engineering, University of California, Irvine, 4200 Engineering Gateway, Irvine, CA, 92697-3975, USA.
authors.forename: Marc
authors.initials: M
authors.lastname: Soriano Baliarda
authors.affiliation: Department of Mechanical and Aerospace Engineering, University of California, Irvine, 4200 Engineering Gateway, Irvine, CA, 92697-3975, USA.
authors.forename: Noemi
authors.initials: N
authors.lastname: Bonessio
authors.affiliation: Department of Mechanical and Aerospace Engineering, University of California, Irvine, 4200 Engineering Gateway, Irvine, CA, 92697-3975, USA.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Valdevit
authors.affiliation: The Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California, Irvine, 2400 Engineering Hall, Irvine, CA, 92697-2730, USA. arashkh@uci.edu.|Department of Biomedical Engineering, University of California, Irvine, 3120 Natural Sciences II, Irvine, CA, 92697-2715, USA. arashkh@uci.edu.|Department of Mechanical and Aerospace Engineering, University of California, Irvine, 4200 Engineering Gateway, Irvine, CA, 92697-3975, USA. arashkh@uci.edu.
authors.forename: Arash
authors.identifier: http://orcid.org/0000-0003-3864-1359
authors.initials: A
authors.lastname: Kheradvar
mesh_terms: D000497:Alloys; D006349:Heart Valve Diseases / Q000503:physiopathology / Q000601:surgery; D006350:Heart Valve Prosthesis; D006801:Humans; D008955:Models, Cardiovascular; D011474:Prosthesis Design; D013526:Surgical Mesh; D054457:Tissue Scaffolds
chemical_list: D000497:Alloys; C013616:nitinol
keywords: Computational modeling; Heart valve; Hybrid heart valve; Hybrid tissue engineering approach; Nitinol mesh; Non-degradable; Scaffold