title: Acute pancreatitis patient registry to examine novel therapies in clinical experience (APPRENTICE): an international, multicenter consortium for the study of acute pancreatitis.
abstract: BACKGROUND
  We have established a multicenter international consortium to better understand the natural history of acute pancreatitis (AP) worldwide and to develop a platform for future randomized clinical trials.
  
  
  METHODS
  The AP patient registry to examine novel therapies in clinical experience (APPRENTICE) was formed in July 2014. Detailed web-based questionnaires were then developed to prospectively capture information on demographics, etiology, pancreatitis history, comorbidities, risk factors, severity biomarkers, severity indices, health-care utilization, management strategies, and outcomes of AP patients.
  
  
  RESULTS
  Between November 2015 and September 2016, a total of 20 sites (8 in the United States, 5 in Europe, 3 in South America, 2 in Mexico and 2 in India) prospectively enrolled 509 AP patients. All data were entered into the REDCap (Research Electronic Data Capture) database by participating centers and systematically reviewed by the coordinating site (University of Pittsburgh). The approaches and methodology are described in detail, along with an interim report on the demographic results.
  
  
  CONCLUSIONS
  APPRENTICE, an international collaboration of tertiary AP centers throughout the world, has demonstrated the feasibility of building a large, prospective, multicenter patient registry to study AP. Analysis of the collected data may provide a greater understanding of AP and APPRENTICE will serve as a future platform for randomized clinical trials.
authors.affiliation: Division of Gastroenterology and Hepatology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA (Georgios I. Papachristou, Jorge D. Machicado, Phil J. Greer, Mohannad Dugum, Efstratios Koutroumpakis Amir Gougol).
authors.forename: Georgios I
authors.initials: GI
authors.lastname: Papachristou
authors.affiliation: Division of Gastroenterology and Hepatology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA (Georgios I. Papachristou, Jorge D. Machicado, Phil J. Greer, Mohannad Dugum, Efstratios Koutroumpakis Amir Gougol).
authors.forename: Jorge D
authors.initials: JD
authors.lastname: Machicado
authors.affiliation: Cleveland Clinic Foundation, Cleveland, Ohio, USA (Tyler Stevens, Tiffany Chua).
authors.forename: Tyler
authors.initials: T
authors.lastname: Stevens
authors.affiliation: Apollo Gleneagles Hospitals Kolkata, Kolkata, India (Mahesh Kumar Goenka, Subhash Ch. Tewari).
authors.forename: Mahesh Kumar
authors.initials: MK
authors.lastname: Goenka
authors.affiliation: Hospital Nacional de Itauguá, Itaugua, Paraguay (Miguel Ferreira).
authors.forename: Miguel
authors.initials: M
authors.lastname: Ferreira
authors.affiliation: Hospital Nacional "Profesor Alejandro Posadas", Buenos Aires, Argentina (Silvia C. Gutierrez).
authors.forename: Silvia C
authors.initials: SC
authors.lastname: Gutierrez
authors.affiliation: Johns Hopkins Medical Institutions, Baltimore, Maryland, USA (Vikesh K. Singh Ayesha Kamal, Venkata Akshintalaf).
authors.forename: Vikesh K
authors.initials: VK
authors.lastname: Singh
authors.affiliation: Johns Hopkins Medical Institutions, Baltimore, Maryland, USA (Vikesh K. Singh Ayesha Kamal, Venkata Akshintalaf).
authors.forename: Ayesha
authors.initials: A
authors.lastname: Kamal
authors.affiliation: Universidad Autónoma de Nueva León, Monterrey, Mexico (Jose A. Gonzalez-Gonzalez).
authors.forename: Jose A
authors.initials: JA
authors.lastname: Gonzalez-Gonzalez
authors.affiliation: Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán-Universidad Autónoma de Mexico, Mexico City, Mexico (Mario Pelaez-Luna).
authors.forename: Mario
authors.initials: M
authors.lastname: Pelaez-Luna
authors.affiliation: Georgetown University Hospital, Washington, DC, USA (Aiste Gulla); Lithuanian University of Health Sciences, Kaunas, Lithuania (Aiste Gulla).
authors.forename: Aiste
authors.initials: A
authors.lastname: Gulla
authors.affiliation: Second Department of Surgery, University Emergency Hospital Bucharest, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania (Narcis O. Zarnescu).
authors.forename: Narcis O
authors.initials: NO
authors.lastname: Zarnescu
authors.affiliation: Attikon University General Hospital, Athens, Greece (Konstantinos Triantafyllou).
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Triantafyllou
authors.affiliation: University of Medicine and Pharmacy "Iuliu Hatieganu", Cluj-Napoca, Romania (Sorin T. Barbu).
authors.forename: Sorin T
authors.initials: ST
authors.lastname: Barbu
authors.affiliation: Indiana University School of Medicine, Indianapolis, Indiana, USA (Jeffrey Easler).
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Easler
authors.affiliation: Hospital General de Argudos "Dr. Cosme Argerich", Buenos Aires, Argentina (Carlos Ocampo).
authors.forename: Carlos
authors.initials: C
authors.lastname: Ocampo
authors.affiliation: Digestive and Liver Disease Unit, S. Andrea Hospital, Sapienza University of Rome, Rome, Italy (Gabriele Capurso, Livia Archibugi).
authors.forename: Gabriele
authors.initials: G
authors.lastname: Capurso
authors.affiliation: Digestive and Liver Disease Unit, S. Andrea Hospital, Sapienza University of Rome, Rome, Italy (Gabriele Capurso, Livia Archibugi).
authors.forename: Livia
authors.initials: L
authors.lastname: Archibugi
authors.affiliation: Medical University of South Carolina, Charleston, South Carolina, USA (Gregory A. Cote).
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Cote
authors.affiliation: University of Tennessee College of Medicine, Chattanooga, Tennessee, USA (Louis Lambiase).
authors.forename: Louis
authors.initials: L
authors.lastname: Lambiase
authors.affiliation: Postgraduate Institute of Medical Education and Research, Chandigarh, India (Rakesh Kochhar).
authors.forename: Rakesh
authors.initials: R
authors.lastname: Kochhar
authors.affiliation: Cleveland Clinic Foundation, Cleveland, Ohio, USA (Tyler Stevens, Tiffany Chua).
authors.forename: Tiffany
authors.initials: T
authors.lastname: Chua
authors.affiliation: Apollo Gleneagles Hospitals Kolkata, Kolkata, India (Mahesh Kumar Goenka, Subhash Ch. Tewari).
authors.forename: Subhash Ch
authors.initials: SC
authors.lastname: Tiwari
authors.affiliation: Eastern Maine Medical Center, Maine, Bangor, USA (Haq Nawaz).
authors.forename: Haq
authors.initials: H
authors.lastname: Nawaz
authors.affiliation: Stanford University, Stanford, California, USA (Walter G. Park).
authors.forename: Walter G
authors.initials: WG
authors.lastname: Park
authors.affiliation: Department of Gastroenterology, Hospital General Universitario de Alicante, Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL - Fundación FISABIO), Alicante, Spain (Enrique de-Madaria).
authors.forename: Enrique
authors.initials: E
authors.lastname: de-Madaria
authors.affiliation: University Hospitals Cleveland Medical Center, Ohio, USA (Peter J. Lee).
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Lee
authors.affiliation: Kaiser Permanente, Pasadena, California, USA (Bechien U. Wu).
authors.forename: Bechien U
authors.initials: BU
authors.lastname: Wu
authors.affiliation: Division of Gastroenterology and Hepatology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA (Georgios I. Papachristou, Jorge D. Machicado, Phil J. Greer, Mohannad Dugum, Efstratios Koutroumpakis Amir Gougol).
authors.forename: Phil J
authors.initials: PJ
authors.lastname: Greer
authors.affiliation: Division of Gastroenterology and Hepatology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA (Georgios I. Papachristou, Jorge D. Machicado, Phil J. Greer, Mohannad Dugum, Efstratios Koutroumpakis Amir Gougol).
authors.forename: Mohannad
authors.initials: M
authors.lastname: Dugum
authors.affiliation: Division of Gastroenterology and Hepatology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA (Georgios I. Papachristou, Jorge D. Machicado, Phil J. Greer, Mohannad Dugum, Efstratios Koutroumpakis Amir Gougol).
authors.forename: Efstratios
authors.initials: E
authors.lastname: Koutroumpakis
authors.affiliation: Johns Hopkins Medical Institutions, Baltimore, Maryland, USA (Vikesh K. Singh Ayesha Kamal, Venkata Akshintalaf).
authors.forename: Venkata
authors.initials: V
authors.lastname: Akshintala
authors.affiliation: Division of Gastroenterology and Hepatology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA (Georgios I. Papachristou, Jorge D. Machicado, Phil J. Greer, Mohannad Dugum, Efstratios Koutroumpakis Amir Gougol).
authors.forename: Amir
authors.initials: A
authors.lastname: Gougol
keywords: APPRENTICE; Acute pancreatitis; international multicenter consortium; methodology