title: Association of growth factor receptor-bound protein 10 gene polymorphism with superovulation traits in Changbaishan black cattle.
abstract: The application of assisted reproductive technology in animal production benefits the economy and conservation of biological resources. Single nucleotide polymorphism (SNPs) was used as predictive markers for breeding and reproduction. In the present study, we examined the association between a SNP of the grb10 gene and superovulation traits in cattle. Sequencing results indicated a point mutation and statistical analysis showed a significant association of the mutation with superovulation traits. The high number of embryos collected from the heterozygotes suggested that the mutation in the grb10 gene exerted a significant effect on the number of embryos recovered although the quality was not affected. The grb10 gene may serve as a useful biomarker for donor selection.
authors.affiliation: Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Shenzhen, China.|Graduate School, Guangzhou Medical University, Guangzhou, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Shenzhen, China.|Graduate School, Anhui Medical University, Hefei, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Laboratory Animal Center, College of Animal Sciences, Jilin University, Changchun, China zhangjiabao515@163.com.
authors.forename: J B
authors.initials: JB
authors.lastname: Zhang
authors.affiliation: Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Shenzhen, China zhangjiabao515@163.com.
authors.forename: Q
authors.initials: Q
authors.lastname: Deng
mesh_terms: D000818:Animals; D002417:Cattle; D046149:Embryo Culture Techniques; D005260:Female; D051383:GRB10 Adaptor Protein / Q000235:genetics*; D018507:Gene Expression Regulation, Developmental; D017354:Point Mutation; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci; D017422:Sequence Analysis, DNA; D013480:Superovulation / Q000235:genetics*
chemical_list: D051383:GRB10 Adaptor Protein