title: Emerging cardiac non-coding landscape: The importance of meta-analysis.
abstract: The invention of transcriptome-wide deep sequencing technology has fundamentally changed our understanding of the complex networks that mediate cardiac functions. Since its inception, researchers have uncovered various novel pathways and transcripts that could be one day used for therapeutics and diagnostics. The characterization of various non-protein coding RNAs (ncRNAs) has aided the study of cardiac manifestation in more detail. Although numerous studies have unearthed the importance of miRNA and lncRNA, the existence and importance of other ncRNAs have been neglected due to their unusual behaviors and outdated ideologies. Recent studies focused on these neglected molecules have proven that these molecules are functional and of great potential. This review brings into focus some of those ncRNAs that were once thought to be futile and not expressed in the heart with an emphasis on the use of meta-data.
authors.affiliation: Cardiac Hypertrophy Laboratory, Department of Molecular Biology, School of Biological Sciences, Madurai Kamaraj University, Madurai 625 021, Tamilnadu, India. Electronic address: kshanmugharajan101@gmail.com.
authors.forename: K Shanmugha
authors.initials: KS
authors.lastname: Rajan
authors.affiliation: Cardiac Hypertrophy Laboratory, Department of Molecular Biology, School of Biological Sciences, Madurai Kamaraj University, Madurai 625 021, Tamilnadu, India. Electronic address: subbiahr@nrcbsmku.org.
authors.forename: Subbiah
authors.initials: S
authors.lastname: Ramasamy
authors.affiliation: Department of Clinical & Experimental Medicine, University Linkoping, Linkoping Sweden.
authors.forename: J N
authors.initials: JN
authors.lastname: George-William
authors.affiliation: Department of Genetics, School of Biological Sciences, Madurai Kamaraj University, Madurai 625 021, Tamilnadu, India.
authors.forename: Jeyaprakash
authors.initials: J
authors.lastname: Rajendhran
mesh_terms: D005786:Gene Expression Regulation; D053263:Gene Regulatory Networks; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D035683:MicroRNAs / Q000096:biosynthesis / Q000235:genetics; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D062085:RNA, Long Noncoding / Q000096:biosynthesis / Q000235:genetics; D022661:RNA, Untranslated / Q000096:biosynthesis* / Q000235:genetics; D059467:Transcriptome / Q000235:genetics*
chemical_list: D035683:MicroRNAs; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated
keywords: Cardiology; Meta-analysis; Non-coding RNA; piRNA; snoRNA