title: The regulation of the pentose phosphate pathway: Remember Krebs.
abstract: The changes in gene expression and posttranslational modifications of enzymes are comprised in the concept of "coarse control" of the oxidative phase of the pentose phosphate pathway. However, these changes are slow in its implementation. The defensive mechanism against oxidative stress requires a most rapid response, impossible to achieve with coarse regulation systems. Recently, it has been suggested that a quick acceleration mechanism of G6PD activity could be produced by the reduction of NADPH-inhibition of G6PD. The hypothesis opens new ways on possible mechanisms for rapid modulation that could be in accordance with results obtained in the 70s by Krebs. These results seemed outdated in view of the subsequent research. However, they deserve to be re-assessed at present.
authors.affiliation: Department of Biochemistry and Molecular Biology, School of Veterinary, University of Santiago de Compostela, Campus Terra, Lugo E-27002, Spain. Electronic address: juanignacio.ramos@usc.es.
authors.forename: Juan Ignacio
authors.initials: JI
authors.lastname: Ramos-Martinez
mesh_terms: D000818:Animals; D002952:Citric Acid Cycle; D015971:Gene Expression Regulation, Enzymologic; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D006801:Humans; D009249:NADP / Q000378:metabolism; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D010427:Pentose Phosphate Pathway / Q000502:physiology*; D055503:Protein Multimerization; D011499:Protein Processing, Post-Translational
chemical_list: D009249:NADP; D005954:Glucosephosphate Dehydrogenase
keywords: Krebs; Pentose phosphate pathway; Regulation