title: The regulation of acute immune responses to the bacterial lung pathogenLegionella pneumophila.
abstract: Legionella pneumophilacauses Legionnaires' disease, a severe and potentially fatal bacterial pneumonia in immunocompromised individuals. Despite the understanding that a robust inflammatory response is important for control ofL. pneumophilainfection, our understanding of the network of molecular and cellular events within the lung that function to clear the bacterium is not clearly understood. This review compiles our understanding of the various molecular and cellular pathways stimulated upon infection withL. pneumophilaand considers recently published advances that focus on the immune response toL. pneumophilain the lungs of mice. This includes a cooperative network of tissue-resident and inflammatory phagocytes, including alveolar macrophages (AM)s, neutrophils, and inflammatory monocytes/monocyte-derived cells (MC) that contribute to the acute inflammatory response and restrict the bacteria via distinct intracellular pathways. The understanding of this difference in cellular activity in response to infection provides insight into the innate immune responses within the tissues in general and may prompt novel means of clinical management of bacterial infections in an era of increasing emergence of antibiotic resistance.
authors.affiliation: Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, Victoria, Australia; and.
authors.forename: Andrew Stephen
authors.initials: AS
authors.lastname: Brown
authors.affiliation: Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
authors.forename: Chao
authors.initials: C
authors.lastname: Yang
authors.affiliation: Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
authors.forename: Elizabeth Louise
authors.initials: EL
authors.lastname: Hartland
authors.affiliation: Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, Victoria, Australia; and i.vandriel@unimelb.edu.au.
authors.forename: Ian Richard
authors.initials: IR
authors.lastname: van Driel
mesh_terms: D000208:Acute Disease; D000818:Animals; D006801:Humans; D007109:Immunity; D016952:Legionella pneumophila / Q000502:physiology*; D008168:Lung / Q000276:immunology* / Q000382:microbiology*; D010586:Phagocytes / Q000378:metabolism; D051192:Receptors, Pattern Recognition / Q000378:metabolism
chemical_list: D051192:Receptors, Pattern Recognition
keywords: Legionnaires disease; dendritic cells; macrophages; monocytes; neutrophils