title: Nitric oxide as a surgical adjuvant.
abstract: Advances in surgical technology have allowed for previously unconsidered therapeutic interventions. However, the complexity and invasiveness of surgical procedures are not without adverse consequences. Nitric oxide's fundamental role in a host of physiological processes, including angiogenesis, wound and bone healing, thromboresistance, smooth muscle relaxation and inflammation makes it a significant player in accelerating wound healing and mitigating the inflammation of ischemia reperfusion injury common to surgical procedures. In addition, the therapeutic properties of NO have been harnessed for the prophylactic treatment of implant infection and graft failure. In this article, we will discuss the mechanism by which NO mediates these processes, and its perioperative translational applications.
authors.affiliation: Department of Medicine (Division of Dermatology), Albert Einstein College of Medicine, Bronx, NY 10467, USA; Department of Medicine (Division of Dermatology), Albert Einstein College of Medicine, Bronx, NY 10467, USA.
authors.forename: Aimee
authors.initials: A
authors.lastname: Krausz
authors.affiliation: Department of Medicine (Division of Dermatology), Albert Einstein College of Medicine, Bronx, NY 10467, USA; Department of Physiology & Biophysics, Albert Einstein College of Medicine, Bronx, NY 10461, USA; George Washington School of Medicine & Health Sciences, WA, DC 20052, USA; Department of Medicine (Division of Dermatology), Albert Einstein College of Medicine, Bronx, NY 10467, USA; Department of Physiology & Biophysics, Albert Einstein College of Medicine, Bronx, NY 10461, USA; George Washington School of Medicine & Health Sciences, WA, DC 20052, USA.
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Friedman
keywords: blood-contacting devices; ischemia reperfusion injury; wound healing