title: Ostalactones A-C, β- and ε-Lactones with Lipase Inhibitory Activity from the Cultured Basidiomycete Stereum ostrea.
abstract: Ostalactones A-C (1-3), three new β- and ε-lactone natural products, were isolated from the culture broth of the basidiomycete Stereum ostrea. The structures were elucidated by interpretation of HRFABMS and 1D and 2D NMR data. The structures of 1 and 2 are characterized by the presence of a β-lactone containing a fused 4/5 bicyclic core structure. Compound 3 possesses a 2-oxepinone ring system, which is likely to be a biosynthetic precursor of compounds 1 and 2. Ostalactones A (1) and B (2) displayed potent inhibitory activity against human pancreatic lipase.
authors.affiliation: Department of Bio-industrial Technologies, Konkuk University , Seoul 05029, Korea.
authors.forename: Hahk-Soo
authors.identifier: http://orcid.org/0000-0001-9602-6042
authors.initials: HS
authors.lastname: Kang
authors.affiliation: Korea Research Institute of Bioscience and Biotechnology (KRIBB) , Cheongju, Chungbuk 28116, Korea.
authors.forename: Jong-Pyung
authors.initials: JP
authors.lastname: Kim
mesh_terms: D000818:Animals; D001487:Basidiomycota / Q000737:chemistry*; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008049:Lipase / Q000037:antagonists & inhibitors*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D000077403:Orlistat
chemical_list: D007783:Lactones; C000618112:ostalactone A; C000618113:ostalactone B; C000618114:ostalactone C; D000077403:Orlistat; D008049:Lipase; C518354:PNLIP protein, human