title: Maintenance immunosuppressants in the management of antibody-mediated renal allograft rejection: which regimen is best?
abstract: Antibody-mediated rejection (AMR) is a pivotal cause of long-term graft failure following renal transplantation. De novo donor-specific antibody reduction is essential to prevent AMR and improve long-term graft survival in renal transplant recipients. Although the number of early AMR episodes can be successfully controlled by attenuating de novo donor-specific antibodies, the long-term outcomes are unsatisfactory. Numerous studies have focused on new strategies to reverse AMR, but the available evidence suggests that maintenance immunosuppressive agents play important roles. This article reviews data on the use of various maintenance immunosuppressive strategies in the management of AMR, with a focus on antibody-mediated kidney transplant rejection. Its aim is to help provide options benefitting long-term graft survival in renal transplant recipients.
authors.affiliation: Medical Department, Shanghai Roche Pharmaceuticals Ltd, Shanghai 201203, China.
authors.forename: Yiqun
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Medical Department, Shanghai Roche Pharmaceuticals Ltd, Shanghai 201203, China.
authors.forename: Xiaolan
authors.initials: X
authors.lastname: Li
authors.affiliation: Medical Department, Shanghai Roche Pharmaceuticals Ltd, Shanghai 201203, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Renal Transplantation, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510530, China.
authors.forename: Qiquan
authors.initials: Q
authors.lastname: Sun
mesh_terms: D000818:Animals; D000920:Antibody-Dependent Cell Cytotoxicity; D006084:Graft Rejection / Q000276:immunology / Q000517:prevention & control*; D006085:Graft Survival; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D016030:Kidney Transplantation; D060046:Maintenance Chemotherapy; D014184:Transplantation, Homologous
chemical_list: D007166:Immunosuppressive Agents
keywords: antibody-mediated rejection; donor-specific antibody; graft failure; immunosuppressive agents; renal transplant