title: Reversible RNA modifications in meiosis and pluripotency.
abstract: Post-transcriptional RNA modifications were discovered several decades ago, but the reversible nature of RNA modifications has only recently been discovered. Owing to technological advances, knowledge of epitranscriptomic marks and their writers, readers and erasers has recently advanced tremendously. Here we focus on the roles of the dynamic methylation and demethylation of internal adenosines in mRNA in germ cells and pluripotent stem cells.
authors.affiliation: Department of Microbiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.|Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.|Norwegian Center for Stem Cell Research, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
authors.forename: Arne
authors.initials: A
authors.lastname: Klungland
authors.affiliation: Department of Microbiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
authors.forename: John Arne
authors.identifier: 0000-0002-4375-2697
authors.initials: JA
authors.lastname: Dahl
authors.affiliation: Department of Gynecology, Section for Reproductive Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
authors.forename: Gareth
authors.initials: G
authors.lastname: Greggains
authors.affiliation: Department of Gynecology, Section for Reproductive Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
authors.forename: Peter
authors.initials: P
authors.lastname: Fedorcsak
authors.affiliation: Department of Microbiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.|Norwegian Center for Stem Cell Research, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
authors.forename: Adam
authors.initials: A
authors.lastname: Filipczyk
mesh_terms: D000818:Animals; D044127:Epigenesis, Genetic / Q000235:genetics*; D006801:Humans; D008540:Meiosis / Q000235:genetics*; D039904:Pluripotent Stem Cells / Q000166:cytology / Q000378:metabolism*; D012313:RNA / Q000737:chemistry* / Q000235:genetics*
chemical_list: D012313:RNA