title: Galangin, a dietary flavonoid, improves antioxidant status and reduces hyperglycemia-mediated oxidative stress in streptozotocin-induced diabetic rats.
abstract: OBJECTIVE
  To examine the effect of galangin on hyperglycemia-mediated oxidative stress in streptozotocin (STZ)-induced diabetic rats.
  
  
  METHODS
  Diabetes was induced by intraperitoneal administration of low-dose STZ (40 mg/kg body weight (BW)) into male albino Wistar rats. Galangin (8 mg/kg BW) or glibenclamide (600 µg/kg BW) was given orally, once daily for 45 days to normal and STZ-induced diabetic rats.
  
  
  RESULTS
  Diabetic rats showed significantly increased levels of plasma glucose, thiobarbituric acid reactive substances, lipid hydroperoxides, and conjugated dienes. The levels of insulin and non-enzymatic antioxidants (vitamin C, vitamin E, reduced glutathione) and the activity of enzymatic antioxidants (superoxide dismutase, catalase, glutathione peroxidase, and glutathione-S-transferase (GST)) were decreased significantly in diabetic control rats. These altered plasma glucose, insulin, lipid peroxidation products, enzymatic and non-enzymatic antioxidants ions were reverted to near-normal level after the administration of galangin and glibenclamide.
  
  
  CONCLUSIONS
  The present study shows that galangin decreased oxidative stress and increased antioxidant status in diabetic rats, which may be due to its antidiabetic and antioxidant potential.
authors.affiliation: a Department of Food Sciences and Nutrition , College of Food and Agriculture Sciences, King Saud University , Riyadh , Saudi Arabia.
authors.forename: Amal A
authors.initials: AA
authors.lastname: Aloud
authors.affiliation: b Department of Community Health Sciences , College of Applied Medical Sciences, King Saud University , Riyadh , Saudi Arabia.
authors.forename: Chinnadurai
authors.initials: C
authors.lastname: Veeramani
authors.affiliation: b Department of Community Health Sciences , College of Applied Medical Sciences, King Saud University , Riyadh , Saudi Arabia.
authors.forename: Chandramohan
authors.initials: C
authors.lastname: Govindasamy
authors.affiliation: b Department of Community Health Sciences , College of Applied Medical Sciences, King Saud University , Riyadh , Saudi Arabia.
authors.forename: Mohammed A
authors.initials: MA
authors.lastname: Alsaif
authors.affiliation: b Department of Community Health Sciences , College of Applied Medical Sciences, King Saud University , Riyadh , Saudi Arabia.
authors.forename: Ahmed S
authors.initials: AS
authors.lastname: El Newehy
authors.affiliation: b Department of Community Health Sciences , College of Applied Medical Sciences, King Saud University , Riyadh , Saudi Arabia.
authors.forename: Khalid S
authors.initials: KS
authors.lastname: Al-Numair
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001205:Ascorbic Acid / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000378:metabolism; D005419:Flavonoids / Q000627:therapeutic use*; D006943:Hyperglycemia / Q000188:drug therapy* / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D010084:Oxidation-Reduction / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin / Q000633:toxicity; D014810:Vitamin E / Q000378:metabolism
chemical_list: D000975:Antioxidants; D005419:Flavonoids; D014810:Vitamin E; C037032:galangin; D013311:Streptozocin; D001205:Ascorbic Acid
keywords: Streptozotocin; antioxidant; diabetes; galangin; lipid peroxidation