title: Association Study of Polymorphisms of Epidermal Growth Factor and Epidermal Growth Factor Receptor With Benign Prostatic Hyperplasia in a Korean Population.
abstract: OBJECTIVE
  Recent studies have suggested that specific single-nucleotide polymorphisms (SNPs) contribute to the clinical features of benign prostatic hyperplasia (BPH). In this study, we investigated the relationships of genetic polymorphisms of the epidermal growth factor (EGF) gene and the epidermal growth factor receptor (EGFR) gene with BPH.
  
  
  METHODS
  A total of 218 patients with BPH were enrolled in this study. We evaluated the relationship between eight SNPs in theEGFandEGFRgenes and prostate volume, prostate-specific antigen (PSA), and International Prostate Symptom Score of BPH patients. Each SNP was genotyped by direct sequencing. Statistical analysis applying codominant, dominant, recessive, and log-additive models was performed via logistic regression.
  
  
  RESULTS
  The rs11568943 and rs11569017 SNPs in theEGFgene showed significant associations with prostate volume (rs11568943: P=0.038 in the log-additive model, P=0.024 in the allele distribution; rs11569017, P=0.031 in the dominant model, P=0.028 in the log-additive model, P=0.020 in the allele distribution). Additionally, the rs3756261, rs11568943, and rs11569017 SNPs of theEGFgene and the rs2293347 SNP of theEGFRgene were associated with PSA levels (P<0.05 in each model, respectively).
  
  
  CONCLUSIONS
  These results suggest that theEGFgene may affect prostate volume. In addition, theEGFandEGFRgenes may be associated with PSA levels in patients with BPH.
authors.affiliation: Kohwang Medical Research Institute, Kyung Hee University School of Medicine, Seoul, Korea.
authors.forename: Su Kang
authors.identifier: 0000-0001-6178-8514
authors.initials: SK
authors.lastname: Kim
authors.affiliation: Department of Emergency Medicine, Kyung Hee University School of Medicine, Seoul, Korea.
authors.forename: Hyun Kyung
authors.identifier: 0000-0002-8388-8783
authors.initials: HK
authors.lastname: Park
authors.affiliation: Department of Emergency Medicine, Kyung Hee University School of Medicine, Seoul, Korea.
authors.forename: Han Sung
authors.identifier: 0000-0003-1378-9533
authors.initials: HS
authors.lastname: Choi
authors.affiliation: Department of Urology, Kyung Hee University School of Medicine, Seoul, Korea.
authors.forename: Koo Han
authors.identifier: 0000-0001-7952-7902
authors.initials: KH
authors.lastname: Yoo
authors.affiliation: Kohwang Medical Research Institute, Kyung Hee University School of Medicine, Seoul, Korea.
authors.forename: Joo-Ho
authors.identifier: 0000-0003-3517-7175
authors.initials: JH
authors.lastname: Chung
keywords: Epidermal Growth Factor; Epidermal Growth Factor Receptor; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Prostatic Hyperplasia