title: Assessment of the left atrial appendage structure and morphology: comparison of real-time three-dimensional transesophageal echocardiography and computed tomography.
abstract: In this study, the left atrial appendage (LAA) structure and morphology were assessed using real-time three-dimensional transesophageal echocardiography (RT3D-TEE) and enhanced cardiac computed tomography (CT) scanning, and the two measurements obtained using these different techniques were compared. Two hundred nonvalvular atrial fibrillation (NVAF) patients who were prepared to undergo radiofrequency ablation were enrolled, and 62 controls were enrolled prospectively. RT3D-TEE and CT were performed, and the following parameters were measured: LAA orifice diameter, area, depth, maximum volume, and emptying velocity. The differences between the NVAF patients and controls were compared, and the differences and correlations in the LAA parameters between the two imaging techniques were assessed. The NVAF patients had significantly bigger orifice sizes, orifice areas, and maximum volumes, and lower emptying rates. The AF cohort had roughly equal proportions of the four morphological types, whereas the controls predominantly had the windsock type. A Bland-Altman analysis demonstrated that the LAA measurements obtained using RT3D-TEE were lower than those obtained with the CT. However, linear regression analysis showed the good correlations between the RT3D-TEE and CT measurements of the LAA orifice area, depth and volume (r = 0.86, 0.63, and 0.75, respectively). The use of RT3D-TEE for the visualization and quantitative analysis of LAA parameters is feasible, and the obtained measurements correlate well with those obtained with cardiac CT. This technique may be an ideal tool for guiding LAA occlusion procedures, and combining these two methods may enhance the accuracy of LAA measurements.
authors.affiliation: Department of Cardiology, West China Hospital of Sichuan University, No. 37 Guo Xue Street, Chengdu, Sichuan, 610041, China.
authors.forename: Wenjuan
authors.initials: W
authors.lastname: Bai
authors.affiliation: Department of Cardiology, West China Hospital of Sichuan University, No. 37 Guo Xue Street, Chengdu, Sichuan, 610041, China.
authors.forename: Zhongxiu
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of Cardiology, West China Hospital of Sichuan University, No. 37 Guo Xue Street, Chengdu, Sichuan, 610041, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Tang
authors.affiliation: Department of Cardiology, West China Hospital of Sichuan University, No. 37 Guo Xue Street, Chengdu, Sichuan, 610041, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Radiology, West China Hospital of Sichuan University, NO. 37 Guo Xue Street, Chengdu, Sichuan, 610041, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Cheng
authors.affiliation: Department of Cardiology, West China Hospital of Sichuan University, No. 37 Guo Xue Street, Chengdu, Sichuan, 610041, China. 27484197@qq.com.
authors.forename: Li
authors.initials: L
authors.lastname: Rao
mesh_terms: D000328:Adult; D000368:Aged; D020517:Atrial Appendage / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000601:surgery; D001281:Atrial Fibrillation / Q000175:diagnosis* / Q000503:physiopathology / Q000601:surgery; D016279:Atrial Function, Left; D016022:Case-Control Studies; D017115:Catheter Ablation; D016009:Chi-Square Distribution; D002681:China; D018619:Echocardiography, Doppler, Pulsed; D019560:Echocardiography, Three-Dimensional; D017548:Echocardiography, Transesophageal; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D011237:Predictive Value of Tests; D011446:Prospective Studies; D015203:Reproducibility of Results; D014057:Tomography, X-Ray Computed
keywords: Computed tomography; Left atrial appendage; Nonvalvular atrial fibrillation; Real-time three-dimensional transesophageal echocardiography