title: Directional Fluid Transport across Organ-Blood Barriers: Physiology and Cell Biology.
abstract: Directional fluid flow is an essential process for embryo development as well as for organ and organism homeostasis. Here, we review the diverse structure of various organ-blood barriers, the driving forces, transporters, and polarity mechanisms that regulate fluid transport across them, focusing on kidney-, eye-, and brain-blood barriers. We end by discussing how cross talk between barrier epithelial and endothelial cells, perivascular cells, and basement membrane signaling contribute to generate and maintain organ-blood barriers.
authors.affiliation: Margaret Dyson Vision Research Institute, Department of Ophthalmology, Weill Cornell Medical College, New York, New York 10065.
authors.forename: Paulo S
authors.initials: PS
authors.lastname: Caceres
authors.affiliation: Margaret Dyson Vision Research Institute, Department of Ophthalmology, Weill Cornell Medical College, New York, New York 10065.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Benedicto
authors.affiliation: Margaret Dyson Vision Research Institute, Department of Ophthalmology, Weill Cornell Medical College, New York, New York 10065.
authors.forename: Guillermo L
authors.initials: GL
authors.lastname: Lehmann
authors.affiliation: Margaret Dyson Vision Research Institute, Department of Ophthalmology, Weill Cornell Medical College, New York, New York 10065.
authors.forename: Enrique J
authors.initials: EJ
authors.lastname: Rodriguez-Boulan
mesh_terms: D001692:Biological Transport / Q000502:physiology*; D016764:Cell Polarity; D042783:Endothelial Cells / Q000166:cytology; D005109:Extracellular Matrix / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D015398:Signal Transduction