title: Drug-induced ototoxicity: Mechanisms, Pharmacogenetics, and protective strategies.
abstract: Drug ototoxicity limits the quality of life of patients after treatment, having serious consequences, especially for psychosocial development of children. Although the ototoxicity of many drugs resolves after treatment discontinuation, the use of platinum derivatives and aminoglycosides is associated with permanent hearing loss. In this review, we have listed ototoxic drugs and the mechanisms by which they damage the ears. Moreover, possible protective strategies and important methods for early detection of ototoxic effects are discussed.
authors.affiliation: Department of Pediatric Hematology and Oncology, University Children's Hospital of Muenster, Muenster, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Lanvers-Kaminsky
authors.affiliation: Department of Phoniatrics and Pedaudiology, University Hospital of Muenster, Muenster, Germany.
authors.forename: Ag Am
authors.initials: AA
authors.lastname: Zehnhoff-Dinnesen
authors.affiliation: Department of Phoniatrics and Pedaudiology, University Hospital of Muenster, Muenster, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Parfitt
authors.affiliation: Experimental Nephrology, Department of Internal Medicine D, University Hospital of Muenster, Muenster, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Ciarimboli
mesh_terms: D000617:Aminoglycosides / Q000009:adverse effects; D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects; D002648:Child; D064420:Drug-Related Side Effects and Adverse Reactions / Q000453:epidemiology / Q000235:genetics* / Q000517:prevention & control*; D004423:Ear / Q000503:physiopathology; D034381:Hearing Loss / Q000139:chemically induced* / Q000453:epidemiology / Q000235:genetics / Q000503:physiopathology* / Q000517:prevention & control*; D006801:Humans; D010597:Pharmacogenetics
chemical_list: D000617:Aminoglycosides; D000970:Antineoplastic Agents