title: Familial diffuse pulmonary ossification: A possible genetic disorder.
abstract: Diffuse pulmonary ossification (DPO) is an uncommon disease that is characterized by the widespread formation of ectopic bone in the lungs. Herein, we describe two familial cases of DPO. The patients were a 47-year-old woman and her 76-year-old father. Both patients had a history of recurrent cough, and their chest images showed multiple nodules with ossification. No underlying diseases that might have caused DPO were evident; however, the female patient also had congenital finger hypoplasia and deformity. The present cases indicate the possibility that DPO might be partly associated with genetic disorders.
authors.affiliation: Department of Respiratory Medicine, Fukuoka University Hospital, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. Electronic address: yoshi-kino@umin.ac.jp.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Kinoshita
authors.affiliation: Division of Respiratory Medicine, Department of Internal Medicine, National Hospital Organization, Kokura Medical Center, 10-1 Harugaoka, Kokura-minamiku, Kitakyushu 802-8533, Japan. Electronic address: icchikom@yahoo.co.jp.
authors.forename: Ichiko
authors.initials: I
authors.lastname: Mizuguchi
authors.affiliation: Division of Respiratory Medicine, Department of Internal Medicine, National Hospital Organization, Kokura Medical Center, 10-1 Harugaoka, Kokura-minamiku, Kitakyushu 802-8533, Japan. Electronic address: hida@kokura2.hosp.go.jp.
authors.forename: Kouko
authors.initials: K
authors.lastname: Hidaka
authors.affiliation: Department of Respiratory Medicine, Fukuoka University Hospital, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. Electronic address: hishii@fukuoka-u.ac.jp.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ishii
authors.affiliation: Department of Respiratory Medicine, Fukuoka University Hospital, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. Electronic address: watanabe@fukuoka-u.ac.jp.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Watanabe
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology; D017563:Lung Diseases, Interstitial / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009999:Ossification, Heterotopic / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology; D014057:Tomography, X-Ray Computed
keywords: Diffuse pulmonary ossification; Ectopic bone formation; Familial occurrence; Nodular pulmonary ossification