title: Are the EQ-5D-3L and the ICECAP-O responsive among older adults with impaired mobility? Evidence from the Vancouver Falls Prevention Cohort Study.
abstract: Preference-based generic measures are gaining increased use in mobility research to assess health-related quality of life and wellbeing. Hence, we examined the responsiveness of these two measures among individuals at risk of mobility impairment among adults aged ≥70 years.
  
  
  
  We conducted a 12-month prospective cohort study of community-dwelling older adults (n = 288 to n = 341 depending on analysis) who were seen at the Vancouver Falls Prevention Clinic who had a history of at least one fall in the previous 12 months. We compared the responsiveness of the EuroQol-5 Domain-3 Level (EQ-5D-3L) and the index of capability for older adults (ICECAP-O) by examining changes in these measures over time (i.e., over 6 and 12 months) and by examining whether their changes varied as a function of having experienced 2 or more falls over 6 and 12 months.
  
  
  
  Only the ICECAP-O showed a significant change over time from baseline through 12 months; however, neither measure showed change that exceeded the standard error of the mean. Both measures were responsive to falls that occurred during the first 6 months of the study (p < .05). These effects appeared to be amplified among individuals identified as having mild cognitive impairment (MCI) at baseline (p < .01). Additionally, the EQ-5D-3L was responsive among fallers who did not have MCI as well as individuals with MCI who did not fall (p < .05).
  
  
  
  This study provides initial evidence suggesting that the EQ-5D-3L is generally more responsive, particularly during the first 6 months of falls tracking among older adults at risk of future mobility impairment.
authors.affiliation: Center for Hip Health and Mobility, Robert HN Ho Building 2635 Laurel St, Vancouver, BC, V5Z 1M9, Canada.
authors.forename: Jennifer C
authors.initials: JC
authors.lastname: Davis
authors.affiliation: Center for Hip Health and Mobility, Robert HN Ho Building 2635 Laurel St, Vancouver, BC, V5Z 1M9, Canada.
authors.forename: John R
authors.initials: JR
authors.lastname: Best
authors.affiliation: Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, V6T 2B5, Canada.
authors.forename: Larry
authors.initials: L
authors.lastname: Dian
authors.affiliation: Aging, Mobility, and Cognitive Neuroscience Lab, Department of Physical Therapy, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, V6T 2B5, Canada.|Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
authors.forename: Karim M
authors.initials: KM
authors.lastname: Khan
authors.affiliation: Center for Hip Health and Mobility, Robert HN Ho Building 2635 Laurel St, Vancouver, BC, V5Z 1M9, Canada.
authors.forename: Chun Liang
authors.initials: CL
authors.lastname: Hsu
authors.affiliation: Center for Hip Health and Mobility, Robert HN Ho Building 2635 Laurel St, Vancouver, BC, V5Z 1M9, Canada.
authors.forename: Wency
authors.initials: W
authors.lastname: Chan
authors.affiliation: Center for Hip Health and Mobility, Robert HN Ho Building 2635 Laurel St, Vancouver, BC, V5Z 1M9, Canada.
authors.forename: Winnie
authors.initials: W
authors.lastname: Cheung
authors.affiliation: Center for Hip Health and Mobility, Robert HN Ho Building 2635 Laurel St, Vancouver, BC, V5Z 1M9, Canada. teresa.ambrose@ubc.ca.|Aging, Mobility, and Cognitive Neuroscience Lab, Department of Physical Therapy, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, V6T 2B5, Canada. teresa.ambrose@ubc.ca.|Department of Medicine, University of British Columbia, Vancouver, BC, Canada. teresa.ambrose@ubc.ca.|Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, V6T 2B5, Canada. teresa.ambrose@ubc.ca.
authors.forename: Teresa
authors.initials: T
authors.lastname: Liu-Ambrose
mesh_terms: D000058:Accidental Falls / Q000517:prevention & control*; D000368:Aged; D000369:Aged, 80 and over; D001955:British Columbia; D015331:Cohort Studies; D005260:Female; D016330:Frail Elderly / Q000523:psychology*; D006299:Health Services for the Aged; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D051346:Mobility Limitation; D011446:Prospective Studies; D011788:Quality of Life; D015203:Reproducibility of Results
keywords: Falls; Mobility impairment; Older adults; Responsiveness