title: [Vismodegib for basal cell carcinoma: targeted therapy in case of locally advanced or metastasised disease].
abstract: The development of the hedgehog pathway inhibitor vismodegib provides a new treatment option for metastasised and locally advanced basal cell carcinoma in which surgical excision or radiotherapy is contraindicated. Only a fraction of patients with basal cell carcinoma are eligible for this therapy, but it is effective in the majority of those who do receive vismodegib. However, development of tumour resistance is quite common and adverse events frequently lead to discontinuation of therapy. Intermittent treatment or combination therapy could reduce the occurrence of tumour resistance and diminish toxicity. We present three patients who were successfully treated with vismodegib: a 73-year-old man with locally advanced basal cell carcinoma, an 82-year-old man with basal cell carcinoma that had metastasised to the lungs, and a 42-year-old man with Gorlin syndrome.
authors.affiliation: MUMC+, Maastricht.
authors.forename: M G H C
authors.initials: MG
authors.lastname: Reinders
authors.forename: J B
authors.initials: JB
authors.lastname: Terra
authors.forename: A K L
authors.initials: AK
authors.lastname: Reyners
authors.forename: M J
authors.initials: MJ
authors.lastname: Aarts
authors.forename: E R M
authors.initials: ER
authors.lastname: de Haas
authors.forename: K
authors.initials: K
authors.lastname: Mosterd
mesh_terms: D000328:Adult; D000368:Aged; D000813:Anilides / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002280:Basal Cell Carcinoma / Q000188:drug therapy*; D019465:Craniofacial Abnormalities / Q000188:drug therapy; D018450:Disease Progression; D005124:Eye Abnormalities / Q000188:drug therapy; D005532:Foot Deformities, Congenital / Q000188:drug therapy; D006801:Humans; D008297:Male; D058990:Molecular Targeted Therapy; D011725:Pyridines / Q000627:therapeutic use*; D012878:Skin Neoplasms / Q000188:drug therapy*; D013576:Syndactyly / Q000188:drug therapy; D014071:Tooth Abnormalities / Q000188:drug therapy; D016896:Treatment Outcome
chemical_list: D000813:Anilides; D000970:Antineoplastic Agents; C538724:HhAntag691; D011725:Pyridines