title: Limited potential of genetic predisposition scores to predict muscle mass and strength performance in Flemish Caucasians between 19 and 73 years of age.
abstract: Since both muscle mass and strength performance are polygenic in nature, the current study compared four genetic predisposition scores (GPS) in their ability to predict these phenotypes. Data were gathered within the framework of the first-generation Flemish Policy Research Centre "Sport, Physical Activity and Health" (2002-2004). Results are based on muscle characteristics data of 565 Flemish Caucasians (19-73 yr, 365 men). Skeletal muscle mass was determined from bioelectrical impedance. The Biodex dynamometer was used to measure isometric (PTstatic120°) and isokinetic strength (PTdynamic60°and PTdynamic240°), ballistic movement speed (S20%), and muscular endurance (Work) of the knee extensors. Genotyping was done for 153 gene variants, selected on the basis of a literature search and the expression quantitative trait loci of selected genes. Four GPS were designed: a total GPS (based on the sum of all 153 variants, each favorable allele = score 1), a data-driven and weighted GPS [respectively, the sum of favorable alleles of those variants with significant b-coefficients in stepwise regression (GPSdd), and the sum of these variants weighted with their respective partial r2(GPSw)], and an elastic net GPS (based on the variants that were selected by an elastic net regularization; GPSen). It was found that four different models for a GPS were able to significantly predict up to ~7% of the variance in strength performance. GPSenmade the best prediction of SMM and Work. However, this was not the case for the remaining strength performance parameters, where best predictions were made by GPSddand GPSw.
authors.affiliation: Faculty of Kinesiology and Rehabilitation Sciences, Department of Kinesiology, Physical Activity, Sports and Health Research Group, KU Leuven, Leuven, Belgium.
authors.forename: Ruben
authors.initials: R
authors.lastname: Charlier
authors.affiliation: Faculty of Kinesiology and Rehabilitation Sciences, Department of Kinesiology, Physical Activity, Sports and Health Research Group, KU Leuven, Leuven, Belgium.
authors.forename: Maarten
authors.initials: M
authors.lastname: Caspers
authors.affiliation: Faculty of Kinesiology and Rehabilitation Sciences, Department of Kinesiology, Physical Activity, Sports and Health Research Group, KU Leuven, Leuven, Belgium.
authors.forename: Sara
authors.initials: S
authors.lastname: Knaeps
authors.affiliation: Faculty of Physical Education and Physical Therapy, Department of Movement and Sport Sciences, Vrije Universiteit Brussel, Brussels, Belgium; and.
authors.forename: Evelien
authors.initials: E
authors.lastname: Mertens
authors.affiliation: Laboratory for Translational Genetics (Vesalius Research Center), Department of Oncology, VIB and KULeuven, Leuven, Belgium.
authors.forename: Diether
authors.initials: D
authors.lastname: Lambrechts
authors.affiliation: Faculty of Kinesiology and Rehabilitation Sciences, Department of Kinesiology, Physical Activity, Sports and Health Research Group, KU Leuven, Leuven, Belgium.
authors.forename: Johan
authors.initials: J
authors.lastname: Lefevre
authors.affiliation: Faculty of Kinesiology and Rehabilitation Sciences, Department of Kinesiology, Physical Activity, Sports and Health Research Group, KU Leuven, Leuven, Belgium martine.thomis@kuleuven.be.
authors.forename: Martine
authors.initials: M
authors.lastname: Thomis
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength / Q000235:genetics*; D009132:Muscles / Q000033:anatomy & histology* / Q000502:physiology*; D009929:Organ Size; D011110:Polymorphism, Genetic; D012044:Regression Analysis; D044465:White People / Q000235:genetics*; D055815:Young Adult
keywords: elastic net regularization; genetic predisposition score; muscle mass; polygenic nature; strength performance