title: Clinical risk factors, bacterial aetiology, and outcome of urinary tract infection in children hospitalized with diarrhoea in Bangladesh.
abstract: Urinary tract infection (UTI) is common in children aged <5 years with diarrhoea, but little is known about risk factors, aetiology and outcome of such children. We aimed to evaluate these knowledge gaps of UTI in children aged <5 years with diarrhoea. We enrolled all children aged <5 years with diarrhoea admitted to Dhaka Hospital of the International Centre for Diarrhoeal Disease Research, Bangladesh, between May 2011 and April 2013, who had history of fever (⩾38 °C) and obtained a urine sample for culture. Diarrhoea with UTI (confirmed by culture) constituted cases (n = 26) and those without UTI constituted controls (n = 78). Threefold controls were randomly selected. The case-fatality rate was comparable in cases and controls (4% vs. 1%, P = 0·439). Escherichia coli (69%) and Klebsiella (15%) were the most commonly isolated pathogens. Persistent diarrhoea, pneumonia and prior antibiotics use were identified as risk factors for UTI in logistic regression analysis (P < 0·05 for all). Thus, children with diarrhoea presenting with persistent diarrhoea, pneumonia, and prior antibiotic use should be investigated for UTI for their prompt management that may reduce morbidity.
authors.affiliation: Nutrition and Clinical Services Division (NCSD),International Centre for Diarrhoeal Disease Research,Bangladesh (icddr,b), Mohakhali,Dhaka,Bangladesh.
authors.forename: R
authors.initials: R
authors.lastname: Das
authors.affiliation: Nutrition and Clinical Services Division (NCSD),International Centre for Diarrhoeal Disease Research,Bangladesh (icddr,b), Mohakhali,Dhaka,Bangladesh.
authors.forename: T
authors.initials: T
authors.lastname: Ahmed
authors.affiliation: Nutrition and Clinical Services Division (NCSD),International Centre for Diarrhoeal Disease Research,Bangladesh (icddr,b), Mohakhali,Dhaka,Bangladesh.
authors.forename: H
authors.initials: H
authors.lastname: Saha
authors.affiliation: Nutrition and Clinical Services Division (NCSD),International Centre for Diarrhoeal Disease Research,Bangladesh (icddr,b), Mohakhali,Dhaka,Bangladesh.
authors.forename: L
authors.initials: L
authors.lastname: Shahrin
authors.affiliation: Nutrition and Clinical Services Division (NCSD),International Centre for Diarrhoeal Disease Research,Bangladesh (icddr,b), Mohakhali,Dhaka,Bangladesh.
authors.forename: F
authors.initials: F
authors.lastname: Afroze
authors.affiliation: Nutrition and Clinical Services Division (NCSD),International Centre for Diarrhoeal Disease Research,Bangladesh (icddr,b), Mohakhali,Dhaka,Bangladesh.
authors.forename: A S M S B
authors.initials: AS
authors.lastname: Shahid
authors.affiliation: Nutrition and Clinical Services Division (NCSD),International Centre for Diarrhoeal Disease Research,Bangladesh (icddr,b), Mohakhali,Dhaka,Bangladesh.
authors.forename: K M
authors.initials: KM
authors.lastname: Shahunja
authors.affiliation: Nutrition and Clinical Services Division (NCSD),International Centre for Diarrhoeal Disease Research,Bangladesh (icddr,b), Mohakhali,Dhaka,Bangladesh.
authors.forename: P K
authors.initials: PK
authors.lastname: Bardhan
authors.affiliation: Nutrition and Clinical Services Division (NCSD),International Centre for Diarrhoeal Disease Research,Bangladesh (icddr,b), Mohakhali,Dhaka,Bangladesh.
authors.forename: M J
authors.identifier: 0000-0001-9958-3071
authors.initials: MJ
authors.lastname: Chisti
mesh_terms: D001419:Bacteria / Q000145:classification / Q000302:isolation & purification*; D001424:Bacterial Infections / Q000453:epidemiology* / Q000382:microbiology / Q000401:mortality; D001459:Bangladesh / Q000453:epidemiology; D002675:Child, Preschool; D003967:Diarrhea / Q000150:complications* / Q000473:pathology; D005260:Female; D006760:Hospitalization; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009026:Mortality; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome; D014552:Urinary Tract Infections / Q000453:epidemiology* / Q000382:microbiology / Q000401:mortality
keywords: Antibiotic use prior to admission; persistent diarrhoea; pneumonia; urinary tract infection