title: Review: Effects of maternal micronutrient supplementation on placental function.
abstract: Pregnancy is a physiological challenge that may require additional nutritional support. Suboptimal micronutrient intakes and micronutrient deficiencies during pregnancy are a global problem, often leading to poor maternal and child outcomes. Micronutrient supplementation is commonly recommended during pregnancy to support and enhance maternal metabolism. Recent studies suggest that the use of multiple micronutrient supplements may be of benefit during a normal pregnancy and may significantly reduce the risk of preeclampsia, preterm delivery, gestational diabetes, and improve pregnancy outcomes. Given the crucial role that the placenta plays in mediating pregnancy outcomes, it is important to consider the impact of micronutrient supplementation on the mechanisms associated with placental function, as well as maternal and fetal homeostasis. This review will consider the role of key micronutrients in supporting pregnancy and the possible mechanisms by which multiple micronutrients influence placental function and modulate placental oxidative stress and inflammation.
authors.affiliation: Conjoint Endocrine Laboratory, Chemical Pathology, Pathology Queensland, Queensland Health, Herston, Qld 4029, Australia; School of Medicine, University of Queensland, Herston, Qld 4029, Australia; School of Biomedical Sciences, Queensland University of Technology, Brisbane, Qld 4000, Australia.
authors.forename: Kerry
authors.initials: K
authors.lastname: Richard
authors.affiliation: School of Medical Science, Menzies Health Institute Queensland, Griffith University, Gold Coast Campus Southport, Queensland, Australia. Electronic address: o.holland@griffith.edu.au.
authors.forename: Olivia
authors.initials: O
authors.lastname: Holland
authors.affiliation: Conjoint Endocrine Laboratory, Chemical Pathology, Pathology Queensland, Queensland Health, Herston, Qld 4029, Australia.
authors.forename: Kelly
authors.initials: K
authors.lastname: Landers
authors.affiliation: School of Medical Science, Menzies Health Institute Queensland, Griffith University, Gold Coast Campus Southport, Queensland, Australia.
authors.forename: Jessica J
authors.initials: JJ
authors.lastname: Vanderlelie
authors.affiliation: School of Medical Science, Menzies Health Institute Queensland, Griffith University, Gold Coast Campus Southport, Queensland, Australia.
authors.forename: Pierre
authors.initials: P
authors.lastname: Hofstee
authors.affiliation: School of Medical Science, Menzies Health Institute Queensland, Griffith University, Gold Coast Campus Southport, Queensland, Australia.
authors.forename: James S M
authors.initials: JSM
authors.lastname: Cuffe
authors.affiliation: School of Medical Science, Menzies Health Institute Queensland, Griffith University, Gold Coast Campus Southport, Queensland, Australia.
authors.forename: Anthony V
authors.initials: AV
authors.lastname: Perkins
mesh_terms: D019587:Dietary Supplements; D005260:Female; D006801:Humans; D018977:Micronutrients / Q000502:physiology*; D010920:Placenta / Q000502:physiology*; D011247:Pregnancy; D039401:Prenatal Nutritional Physiological Phenomena
chemical_list: D018977:Micronutrients
keywords: Maternal; Micronutrient; Nutrition; Placenta; Pregnancy; Supplement