title: Age- and time-dependent prevalence and incidence of hepatitis C virus infection in drug users in France, 2004-2011: model-based estimation from two national cross-sectional serosurveys.
abstract: Hepatitis C virus (HCV) infection is a public health issue worldwide. Injecting drug use remains the major mode of transmission in developed countries. Monitoring the HCV transmission dynamic over time is crucial, especially to assess the effect of harm reduction measures in drug users (DU). Our objective was to estimate the prevalence and incidence of HCV infection in DU in France using data from a repeated cross-sectional survey conducted in 2004 and 2011. Age- and time-dependent HCV prevalence was estimated through logistic regression models adjusted for HIV serostatus or injecting practices. HCV incidence was estimated from a mathematical model linking prevalence and incidence. HCV prevalence decreased from 58·2% [95% confidence interval (CI) 49·7-66·8] in 2004 to 43·2% (95% CI 38·8-47·7) in 2011. HCV incidence decreased from 7·9/100 person-years (95% CI 6·4-9·4) in 2004 to 4·4/100 person-years (95% CI 3·3-5·9) in 2011. HCV prevalence and incidence were significantly associated with age, calendar time, HIV serostatus and injecting practices. In 2011, the highest estimated incidence was in active injecting DU (11·2/100 person-years). Given the forthcoming objective of generalizing access to new direct antiviral agents for HCV infection, our results contribute to decision-making and policy development regarding treatment scale-up and disease prevention in the DU population.
authors.affiliation: Santé publique France,French National Public Health Agency,Saint-Maurice,France.
authors.forename: L
authors.initials: L
authors.lastname: Leon
authors.affiliation: Santé publique France,French National Public Health Agency,Saint-Maurice,France.
authors.forename: S
authors.initials: S
authors.lastname: Kasereka
authors.affiliation: Centre National de Référence du VIH & INSERM UMR966,Centre Hospitalier Universitaire & Université François-Rabelais,Tours,France.
authors.forename: F
authors.initials: F
authors.lastname: Barin
authors.affiliation: Santé publique France,French National Public Health Agency,Saint-Maurice,France.
authors.forename: C
authors.initials: C
authors.lastname: Larsen
authors.affiliation: Santé publique France,French National Public Health Agency,Saint-Maurice,France.
authors.forename: L
authors.initials: L
authors.lastname: Weill-Barillet
authors.affiliation: Santé publique France,French National Public Health Agency,Saint-Maurice,France.
authors.forename: X
authors.initials: X
authors.lastname: Pascal
authors.affiliation: Department of Virology,Hôpital Henri Mondor,Centre National de Référence des Hépatites B,C et Delta,Créteil,France.
authors.forename: S
authors.initials: S
authors.lastname: Chevaliez
authors.affiliation: Santé publique France,French National Public Health Agency,Saint-Maurice,France.
authors.forename: J
authors.initials: J
authors.lastname: Pillonel
authors.affiliation: Santé publique France,French National Public Health Agency,Saint-Maurice,France.
authors.forename: M
authors.initials: M
authors.lastname: Jauffret-Roustide
authors.affiliation: Santé publique France,French National Public Health Agency,Saint-Maurice,France.
authors.forename: Y
authors.initials: Y
authors.lastname: LE Strat
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D003430:Cross-Sectional Studies; D055030:Drug Users; D005260:Female; D005602:France / Q000453:epidemiology; D015658:HIV Infections / Q000150:complications; D006526:Hepatitis C / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D015995:Prevalence; D015819:Substance Abuse, Intravenous / Q000150:complications*; D013997:Time Factors; D055815:Young Adult
keywords: Drug users; hepatitis C virus; incidence; mixture model; prevalence