title: Differences in hippocampal serotonergic activity in a mouse single prolonged stress paradigm impact discriminant fear acquisition and retention.
abstract: A mouse model of traumatic stress provided insight into a mechanism of individual differences in conditioned fear responding. Hippocampal serotonergic activity (metabolic turnover) was associated with increased behavioral freezing during fear acquisition in a portion of trauma-exposed subjects. These subjects later displayed enhanced fear to the neutral cue during retention. An inability to discriminate fear responses may underlie dysfunctional fear memories in a sub-population of individuals with Posttraumatic Stress Disorder, with contributions from the hippocampal serotonin system.
authors.affiliation: Research & Development Service, John D. Dingell VA Medical Center, 4646 John R St., Detroit, MI 48201, United States; Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 3901 Chrysler Service Drive, Detroit, MI 48201, United States.
authors.forename: Deane E
authors.initials: DE
authors.lastname: Aikins
authors.affiliation: Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 3901 Chrysler Service Drive, Detroit, MI 48201, United States.
authors.forename: John A
authors.initials: JA
authors.lastname: Strader
authors.affiliation: Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 3901 Chrysler Service Drive, Detroit, MI 48201, United States.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Kohler
authors.affiliation: Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 3901 Chrysler Service Drive, Detroit, MI 48201, United States.
authors.forename: Nina
authors.initials: N
authors.lastname: Bihani
authors.affiliation: Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 3901 Chrysler Service Drive, Detroit, MI 48201, United States. Electronic address: sperrine@med.wayne.edu.
authors.forename: Shane A
authors.initials: SA
authors.lastname: Perrine
mesh_terms: D000818:Animals; D003214:Conditioning, Classical / Q000502:physiology*; D003463:Cues; D004195:Disease Models, Animal; D005108:Extinction, Psychological / Q000502:physiology*; D005239:Fear / Q000502:physiology*; D006624:Hippocampus / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D008810:Mice, Inbred C57BL; D012153:Retention, Psychology; D013313:Stress Disorders, Post-Traumatic / Q000503:physiopathology
keywords: Fear conditioning; Hippocampus; PTSD