title: A new phenol glycoside from Physalis angulata.
abstract: A new phenol glycoside, physanguloside A (1), was isolated from Physalis angulata together with four known compounds. We report herein, for the first time, the presence of compounds 2-5 in the genus Physalis. The structures of all the compounds were established by NMR, IR, UV and HRESIMS spectroscopic analyses, and comparison with the literature data. All isolated compounds were assayed for inhibitory activity on nitric oxide production by LPS-induced in RAW 264.7 macrophages.
authors.affiliation: a Tianjin State Key Laboratory of Modern Chinese Medicine and School of Chinese Materia Medica , Tianjin University of Traditional Chinese Medicine , Tianjin , China.|b Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Department of Natural Products Chemistry , School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang , China.
authors.forename: Cheng-Peng
authors.initials: CP
authors.lastname: Sun
authors.affiliation: b Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Department of Natural Products Chemistry , School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang , China.
authors.forename: Xiu-Fang
authors.initials: XF
authors.lastname: Nie
authors.affiliation: a Tianjin State Key Laboratory of Modern Chinese Medicine and School of Chinese Materia Medica , Tianjin University of Traditional Chinese Medicine , Tianjin , China.
authors.forename: Ning
authors.initials: N
authors.lastname: Kang
authors.affiliation: c Key Laboratory of Molecular Pharmacology and Drug Evaluation, Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong , School of Pharmacy, Yantai University , Yantai , China.
authors.forename: Feng
authors.initials: F
authors.lastname: Zhao
authors.affiliation: b Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Department of Natural Products Chemistry , School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang , China.
authors.forename: Li-Xia
authors.initials: LX
authors.lastname: Chen
authors.affiliation: a Tianjin State Key Laboratory of Modern Chinese Medicine and School of Chinese Materia Medica , Tianjin University of Traditional Chinese Medicine , Tianjin , China.|b Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Department of Natural Products Chemistry , School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang , China.
authors.forename: Feng
authors.initials: F
authors.lastname: Qiu
mesh_terms: D000818:Animals; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D032321:Physalis / Q000737:chemistry*
chemical_list: D006027:Glycosides; D010636:Phenols; C000619994:physanguloside A; D009569:Nitric Oxide
keywords: Physalis angulata; nitric oxide; phenol glycoside