title: Agmatine ameliorates adjuvant induced arthritis and inflammatory cachexia in rats.
abstract: The present study investigated the pharmacological effect of agmatine in Complete Freud Adjuvant (CFA) induced arthritis and cachexia in rats. The rats were injected with CFA (0.1ml/rat) to induced symptoms of arthritis. Day 8 onwards of CFA administration, rats were injected daily with agmatine for next 7days, and arthritis score, body weights and food intake were monitored daily (g). Since cachexia is known to produce severe inflammation, malnutrition and inhibition of albumin gene expression, we have also monitored the total proteins, albumin, TNF-α and IL-6 levels in arthritic rats and its modulation by agmatine. In the present study, CFA treated rats showed a progressive reduction in both food intake and body weight. In addition analysis of blood serum of arthritis animals showed a significant reduction in proteins and albumin and significant elevation in tumor necrosis factor (TNF)-α and Interleukins (IL)-6. Chronic agmatine (20-40mg/kg, ip) treatment not only attenuated the signs of arthritis but also reverses anorexia and body weight loss in CFA treated rats. In addition, agmatine restored total protein and albumin and reduces TNF-α and IL-6 levels in arthritis rats. These results suggest that agmatine administration can prevent the body weights loss and symptoms of arthritis via inhibition of inflammatory cytokines.
authors.affiliation: Division of Neuroscience, Department of Pharmacology, Shrimati Kishoritai Bhoyar College of Pharmacy, New Kamptee, Nagpur, (Maharashtra), 441 002, India, India.
authors.forename: Brijesh G
authors.initials: BG
authors.lastname: Taksande
authors.affiliation: Division of Neuroscience, Department of Pharmacology, Shrimati Kishoritai Bhoyar College of Pharmacy, New Kamptee, Nagpur, (Maharashtra), 441 002, India, India.
authors.forename: Dinesh Y
authors.initials: DY
authors.lastname: Gawande
authors.affiliation: Division of Neuroscience, Department of Pharmacology, Shrimati Kishoritai Bhoyar College of Pharmacy, New Kamptee, Nagpur, (Maharashtra), 441 002, India, India.
authors.forename: Chandrabhan T
authors.initials: CT
authors.lastname: Chopde
authors.affiliation: Division of Neuroscience, Department of Pharmacology, Shrimati Kishoritai Bhoyar College of Pharmacy, New Kamptee, Nagpur, (Maharashtra), 441 002, India, India.
authors.forename: Milind J
authors.initials: MJ
authors.lastname: Umekar
authors.affiliation: Division of Neuroscience, Department of Pharmacology, Shrimati Kishoritai Bhoyar College of Pharmacy, New Kamptee, Nagpur, (Maharashtra), 441 002, India, India; Government Colleges of Pharmacy, Kathora Naka, Amravati 444604, Maharashtra, India. Electronic address: nandukotagale@gmail.com.
authors.forename: Nandkishor R
authors.initials: NR
authors.lastname: Kotagale
mesh_terms: D000376:Agmatine / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D001169:Arthritis, Experimental / Q000188:drug therapy* / Q000473:pathology; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D002100:Cachexia / Q000188:drug therapy* / Q000473:pathology; D007249:Inflammation / Q000188:drug therapy / Q000473:pathology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000376:Agmatine
keywords: Agmatine; Arthritis; Cachexia; Complete freud adjuvant; Interleukin; TNF-α