title: Corneal Biomechanical Properties After Penetrating Keratoplasty or Deep Anterior Lamellar Keratoplasty Using the Ocular Response Analyzer: A Meta-Analysis.
abstract: OBJECTIVE
  To evaluate the corneal biomechanical properties of patients who have undergone penetrating keratoplasty (PK) or deep anterior lamellar keratoplasty (DALK) using the ocular response analyzer.
  
  
  METHODS
  Stata 13.0 SE was used for this meta-analysis. Studies in the literature that focused on corneal hysteresis (CH) or corneal resistance factor (CRF) after PK or DALK were retrieved by searching PubMed, Embase, Ovid, and Cochrane databases. We present the results as weighted mean difference (WMD) with a corresponding 95% confidence interval (CI).
  
  
  RESULTS
  Eight studies with a total of 750 eyes were included in the post-PK versus control group, and 4 studies with a total of 218 eyes were included in the post-DALK versus control group. The pooled results showed that CH and CRF were significantly reduced (P < 0.00001) for patients who have undergone PK (WMD = -1.16, 95% CI: -1.73 to -0.60 and WMD = -1.00, 95% CI: -1.61 to -0.40). No significant differences were found in both CH and CRF for patients who have undergone DALK (WMD = -0.27, 95% CI: -0.64 to -0.09 and WMD = -0.15, 95% CI: -0.53 to 0.23).
  
  
  CONCLUSIONS
  This meta-analysis suggested that both CH and CRF had better recovery after corneal transplantation with DALK than PK.
authors.affiliation: *Engineering Research Center of Optical Instruments and Systems, Ministry of Education, Shanghai Key Lab of Modern Optical Systems, University of Shanghai for Science and Technology, Shanghai, China; and †Department of Biomedical Engineering, Florida International University, Miami, FL.
authors.forename: Min-Shan
authors.initials: MS
authors.lastname: Jiang
authors.forename: Jing-Yuan
authors.initials: JY
authors.lastname: Zhu
authors.forename: Xue
authors.initials: X
authors.lastname: Li
authors.forename: Nan-Nan
authors.initials: NN
authors.lastname: Zhang
authors.forename: Xue-Dian
authors.initials: XD
authors.lastname: Zhang
mesh_terms: D001696:Biomechanical Phenomena; D003315:Cornea / Q000503:physiopathology* / Q000601:surgery; D003316:Corneal Diseases / Q000503:physiopathology / Q000601:surgery*; D016039:Corneal Transplantation; D003941:Diagnostic Techniques, Ophthalmological; D004548:Elasticity / Q000502:physiology*; D006801:Humans; D015948:Keratoplasty, Penetrating; D020127:Recovery of Function / Q000502:physiology; D014792:Visual Acuity / Q000502:physiology