title: Altered Gray Matter Volume in Stable Chronic Obstructive Pulmonary Disease with Subclinical Cognitive Impairment: an Exploratory Study.
abstract: Gray matter volume deficits have been identified in cognitively impaired patients with chronic obstructive pulmonary disease (COPD). However, it remains unknown whether the gray matter volume is altered in COPD patients with subclinical cognitive impairment. To determine whether any gray matter abnormalities are present in these patients, neuropsychological tests and structural MRI data were analyzed from 60 patients with COPD and 60 age-, gender-, education-, and handedness-matched normal controls (NCs). The COPD patients had similar Mini-Mental State Examination (MMSE) scores compared with the NCs. However, they had reduced Montreal Cognitive Assessment (MoCA) scores for visuospatial and executive and naming and memory functions (P < 0.001). Voxel-based morphometry (VBM) analysis revealed that the COPD patients had significantly lowered gray matter volumes in several brain regions, including the left precuneus (PrCU), bilateral calcarine (CAL), right superior temporal gyrus/middle temporal gyrus (STG/MTG), bilateral fusiform gyrus (FG), and right inferior parietal lobule (IPL) (P < 0.01, corrected). Importantly, the forced vital capacity (FVC) was found to be associated with the gray matter volume in the calcarine. The present study confirmed that brain structural changes were present in stable COPD patients with subclinical cognitive impairment. These findings may provide new insights into the pathogenesis of COPD.
authors.affiliation: Department of Radiology, Nanfang Hospital Affiliated to Southern Medical University, Guangzhou, Guangdong, 510515, China.|Department of Radiology, Nanshan Hospital Affiliated to Guangdong Medical University, Shenzhen, Guangdong, 518052, China.
authors.forename: Chunrong
authors.initials: C
authors.lastname: Wang
authors.affiliation: School of Information Science and Engineering, Shandong Normal University, Jinan, Shandong, 250014, China.
authors.forename: Yanhui
authors.initials: Y
authors.lastname: Ding
authors.affiliation: Department of Radiology, Nanshan Hospital Affiliated to Guangdong Medical University, Shenzhen, Guangdong, 518052, China.
authors.forename: Bixian
authors.initials: B
authors.lastname: Shen
authors.affiliation: Department of Radiology, Nanshan Hospital Affiliated to Guangdong Medical University, Shenzhen, Guangdong, 518052, China.
authors.forename: Dehong
authors.initials: D
authors.lastname: Gao
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510405, China.
authors.forename: Jie
authors.initials: J
authors.lastname: An
authors.affiliation: Department of Radiology, Nanshan Hospital Affiliated to Guangdong Medical University, Shenzhen, Guangdong, 518052, China.
authors.forename: Kewen
authors.initials: K
authors.lastname: Peng
authors.affiliation: Department of Radiology, Nanshan Hospital Affiliated to Guangdong Medical University, Shenzhen, Guangdong, 518052, China.
authors.forename: Gangqiang
authors.initials: G
authors.lastname: Hou
authors.affiliation: Department of Radiology, Nanshan Hospital Affiliated to Guangdong Medical University, Shenzhen, Guangdong, 518052, China.
authors.forename: Liqiu
authors.initials: L
authors.lastname: Zou
authors.affiliation: Department of Radiology, Nanshan Hospital Affiliated to Guangdong Medical University, Shenzhen, Guangdong, 518052, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Jiang
authors.affiliation: Department of Radiology, Nanfang Hospital Affiliated to Southern Medical University, Guangzhou, Guangdong, 510515, China. qiu-sj@163.com.|Department of Radiology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510405, China. qiu-sj@163.com.
authors.forename: Shijun
authors.initials: S
authors.lastname: Qiu
mesh_terms: D001284:Atrophy / Q000473:pathology; D001921:Brain / Q000473:pathology; D016022:Case-Control Studies; D060825:Cognitive Dysfunction / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D005260:Female; D066128:Gray Matter / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D059906:Neuroimaging; D009483:Neuropsychological Tests; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000473:pathology* / Q000503:physiopathology / Q000523:psychology*; D014797:Vital Capacity / Q000502:physiology
keywords: Brain; Chronic obstructive pulmonary disease (COPD); Cognitive impairment; Gray matter volume; Hypoxia; Voxel-based morphometry (VBM)