title: Functional anatomy of the human thalamus at rest.
abstract: In the present work, we used resting state-fMRI to investigate the functional anatomy of the thalamus at rest by applying an Independent Component Analysis to delineate thalamic substructures into stable and reproducible parcels for the left and right thalamus. We determined 15 functionally distinct thalamic parcels, which differed in laterality and size but exhibited a correspondence with 18 cytoarchitectonally defined nuclei. We characterized their structural connectivity in determining DWI based cortical fiber pathways and found selected projections to different cortical areas. In contrast, the functional connections of these parcels were not confined to certain cortical areas or lobes. We, finally evaluated cortical projections and found particular subcortical and cortical pattern for each parcel, which partly exhibited a correspondence with the thalamo-cortical connectivity maps of the mouse.
authors.affiliation: Max Planck Institute for Biological Cybernetics, Tübingen, Germany.
authors.forename: Vinod Jangir
authors.initials: VJ
authors.lastname: Kumar
authors.affiliation: Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University Nijmegen, The Netherlands.
authors.forename: Erik
authors.initials: E
authors.lastname: van Oort
authors.affiliation: Max Planck Institute for Biological Cybernetics, Tübingen, Germany; Department of Biomedical Magnetic Resonance, University Clinic Tübingen, Germany.
authors.forename: Klaus
authors.initials: K
authors.lastname: Scheffler
authors.affiliation: Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University Nijmegen, The Netherlands; Radboud University Medical Centre, Department of Cognitive Neuroscience, Nijmegen, The Netherlands.
authors.forename: Christian F
authors.initials: CF
authors.lastname: Beckmann
authors.affiliation: Max Planck Institute for Biological Cybernetics, Tübingen, Germany. Electronic address: Wolfgang.Grodd@tuebingen.mpg.de.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Grodd
mesh_terms: D000328:Adult; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D005260:Female; D059907:Functional Neuroimaging / Q000379:methods*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D012146:Rest; D013788:Thalamus / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000502:physiology*
keywords: Cortical connectivity; Diffusion imaging; Histology; Resting state fMRI; Thalamus