title: The Effect of Local Rosuvastatin on Mandibular Fracture Healing.
abstract: Mandibular fracture is the most common injury seen in facial fractures and plays an important role for oral and maxillofacial surgery department. The purpose of this study is to investigate the potential of the local administration of rosuvastatin (RSV) on mandibular fracture healing in rats. Thirty-two rats were divided into 4 groups: group C-14 (control), group R-14, group C-28 (control), and group R-28. A unilateral standard vertical osteotomy was performed right side of the mandibula extending from the tooth to the mandibular basis for each animal. In groups C-14 and C-28 sterile saline treated absorbable collogen sponge was applied to the fracture area, in groups R-14 and R-28 absorbable collogen sponge with saline solution containing 1 mg RSV was applied to the fracture area. Animals in groups C-14 and R-14 were euthanized on the 14th day, groups C-28 and R-28 were euthanized on the 28th day after operation. Stereologic analyses were performed. New bone area and connective tissue volumes were measured. Stereologic analysis showed that group R-14 had significantly more new bone at 2 weeks compared with group C-14. Connective tissue volumes were also significantly higher in R-14. New bone and connective tissue volume differences were not statistically significant between groups C-28 and R-28. Locally administered RSV enhances early bone regeneration on mandibular fracture in rats.
authors.affiliation: *Department of Oral and Maxillofacial Surgery, Bülent Ecevit University, Zonguldak†Department of Oral and Maxillofacial Surgery‡Department of Histology and Embriology, Ondokuz Mayis University, Samsun, Turkey.
authors.forename: Akif
authors.initials: A
authors.lastname: Türer
authors.forename: Mustafa Cenk
authors.initials: MC
authors.lastname: Durmuşlar
authors.forename: Ismail
authors.initials: I
authors.lastname: Şener
authors.forename: Ahmet Ferhat
authors.initials: AF
authors.lastname: Misir
authors.forename: Mehmet Emin
authors.initials: ME
authors.lastname: Önger
mesh_terms: D000287:Administration, Topical; D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects*; D004195:Disease Models, Animal; D017102:Fracture Healing / Q000187:drug effects*; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage; D008337:Mandibular Fractures / Q000601:surgery*; D010027:Osteotomy / Q000379:methods*; D051381:Rats; D017208:Rats, Wistar; D000068718:Rosuvastatin Calcium / Q000008:administration & dosage*
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D000068718:Rosuvastatin Calcium