title: HURTLE CELLS IMMUNOHISTOCHEMICAL ACTIVITIES IN HASHIMOTO THYROIDITIS PARENCHYMA.
abstract: The present study was designed to evaluate the participation and utility of Hǘrtle cells morphological requirment and transformation under Hashimoto autoimmune thyroiditis versus Riedel´s struma. Several markers have been evaluated to detect induced activities of Hǘrtle cells. Study subject - specimens (tissue fragments) collected from TG surgery (thyroidectomy) for mollecular (receptor) diagnosis of Hǘrtle cells activities using routine histological and immunohistochemical samples. 89 cases were selected in Hashimoto thyroiditis diagnosis with Hǘrtle cells history (adenoma and adenomatous grouth of oncocytes). Markers as: TSH receptors, TTF-1, S-100 protein, also anti-TPO and anti-TG levels in blood plasm were detected. It was shown that solid cell claster-nests like agregation of oncocytes and adenomatous growth foci in parafollicular areas with anti-TPO and anti-TG antibodies levels arising while Riedel´s struma shown only large intra- and extra glandular inflammatory proliferative fibrosing process. Large positive expression of TTF-1 and S-100 protein and the negative reaction of TSH receptor factor suggest that Thyroid parenchyma disorganization and mollecular biological atypia with Hǘrtle cells are proceses due to hypothyreoidismus, as well as neuroectodermal cells prominent activities in 70% of Hashimoto cases.
authors.affiliation: I. Javakhishvili Tbilisi State University, Alexandre Natishvili Institute of Morphology, Tbilisi, Georgia.
authors.forename: Z
authors.initials: Z
authors.lastname: Tsagareli
authors.affiliation: I. Javakhishvili Tbilisi State University, Alexandre Natishvili Institute of Morphology, Tbilisi, Georgia.
authors.forename: T
authors.initials: T
authors.lastname: Kvachadze
authors.affiliation: I. Javakhishvili Tbilisi State University, Alexandre Natishvili Institute of Morphology, Tbilisi, Georgia.
authors.forename: E
authors.initials: E
authors.lastname: Melikadze
authors.affiliation: I. Javakhishvili Tbilisi State University, Alexandre Natishvili Institute of Morphology, Tbilisi, Georgia.
authors.forename: L
authors.initials: L
authors.lastname: Metreveli
authors.affiliation: I. Javakhishvili Tbilisi State University, Alexandre Natishvili Institute of Morphology, Tbilisi, Georgia.
authors.forename: E
authors.initials: E
authors.lastname: Nikobadze
authors.affiliation: I. Javakhishvili Tbilisi State University, Alexandre Natishvili Institute of Morphology, Tbilisi, Georgia.
authors.forename: L
authors.initials: L
authors.lastname: Gogiashvili
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood; D001324:Autoantigens / Q000276:immunology; D005260:Female; D005355:Fibrosis; D050031:Hashimoto Disease / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007453:Iodide Peroxidase / Q000276:immunology; D033862:Iron-Binding Proteins / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009687:Nuclear Proteins / Q000378:metabolism; D024862:Oxyphil Cells / Q000378:metabolism*; D000072356:Parenchymal Tissue / Q000378:metabolism* / Q000473:pathology; D011989:Receptors, Thyrotropin / Q000378:metabolism; D009418:S100 Proteins / Q000378:metabolism; D013961:Thyroid Gland / Q000378:metabolism* / Q000473:pathology; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D033862:Iron-Binding Proteins; C000614412:NKX2-1 protein, human; D009687:Nuclear Proteins; D011989:Receptors, Thyrotropin; D009418:S100 Proteins; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors; C006606:anti-thyroglobulin; C056658:TPO protein, human; D007453:Iodide Peroxidase