title: Sugar-sensitive dendrimer films as a sacrificial layer for the preparation of freestanding multilayer films.
abstract: Multilayer thin films composed of poly(vinyl alcohol) (PVA) and phenylboronic acid-bearing poly(amidoamine) dendrimer (PBA-PAMAM) were used as a sacrificial layer for constructing freestanding polyelectrolyte films consisting of poly(styrenesulfonate) (PSS) and poly(allylamine hydrochloride) (PAH). Freestanding (PSS/PAH)15films were successfully released from substrate by exposing composite (PVA/PBA-PAMAM)n/(PSS/PAH)15films (n=5 and 10) to sorbitol solutions under mild conditions at pH7.0-9.0. The film release was accelerated in solutions of higher sorbitol concentrations at pH9.0 as well as in solutions with lower concentration of NaCl. The results were rationalized based on the scission of boronate ester bonds between PBA-PAMAM and PVA in the (PVA/PBA-PAMAM)nlayer due to a competitive binding of sorbitol to PBA-PAMAM.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Tohoku University, Aramaki, Aoba-ku, Sendai 980-8578, Japan.
authors.forename: Fumiya
authors.initials: F
authors.lastname: Sato
authors.affiliation: Graduate School of Pharmaceutical Sciences, Tohoku University, Aramaki, Aoba-ku, Sendai 980-8578, Japan. Electronic address: junanzai@mail.pharm.tohoku.ac.jp.
authors.forename: Jun-Ichi
authors.initials: JI
authors.lastname: Anzai
mesh_terms: D001897:Boronic Acids / Q000737:chemistry; D050091:Dendrimers / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D018625:Microscopy, Atomic Force; D011073:Polyamines / Q000737:chemistry; D000071228:Polyelectrolytes / Q000737:chemistry; D011137:Polystyrenes / Q000737:chemistry; D011142:Polyvinyl Alcohol / Q000737:chemistry; D012965:Sodium Chloride / Q000737:chemistry; D013012:Sorbitol / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D001897:Boronic Acids; D050091:Dendrimers; C104700:PAMAM Starburst; D011073:Polyamines; D000071228:Polyelectrolytes; D011137:Polystyrenes; D012965:Sodium Chloride; D013012:Sorbitol; C003321:polystyrene sulfonic acid; D011142:Polyvinyl Alcohol; C010686:benzeneboronic acid
keywords: Dendrimer; Freestanding film; Layer-by-layer film; Sorbitol