title: Exercise, adipokines and pediatric obesity: a meta-analysis of randomized controlled trials.
abstract: Adipokines are involved in the etiology of diabetes, insulin resistance, and the development of atherosclerosis and other latent-onset complications. The objective of this meta-analysis was to determine the effectiveness of exercise interventions on adipokines in pediatric obesity.
  
  
  
  A computerized search was made using three databases. The analysis was restricted to studies that examined the effect of exercise interventions on adipokines (adiponectin, leptin, resistin and visfatin) in pediatric obesity (6-18 years old). Fourteen randomized controlled trials (347 youths) were included. Weighted mean difference (WMD) and 95% confidence intervals were calculated.
  
  
  
  Exercise was associated with a significant increase in adiponectin (WMD=0.882 μg ml-1, 95% CI, 0.271-1.493) but did not alter leptin and resistin level. Likewise, exercise intensity and change in body fat; as well as total exercise program duration, duration of the sessions, and change in body fat all significantly influenced the effect of exercise on adiponectin and leptin, respectively.
  
  
  
  Exercise seems to increase adiponectin levels in childhood obesity. Our results also suggested that exercise on its own, without the concomitant presence of changes in body composition levels, does not affect leptin levels.
authors.affiliation: Laboratorio de Ciencias de la Actividad Física, el Deporte y la Salud, Universidad de Santiago de Chile, USACH, Santiago, Chile.
authors.forename: A
authors.initials: A
authors.lastname: García-Hermoso
authors.affiliation: Laboratorio de Ciencias de la Actividad Física, el Deporte y la Salud, Universidad de Santiago de Chile, USACH, Santiago, Chile.
authors.forename: R J M
authors.initials: RJ
authors.lastname: Ceballos-Ceballos
authors.affiliation: Laboratorio de Ciencias de la Actividad Física, el Deporte y la Salud, Universidad de Santiago de Chile, USACH, Santiago, Chile.
authors.forename: C E
authors.initials: CE
authors.lastname: Poblete-Aro
authors.affiliation: Endocrine Section-Applied Physiology Laboratory, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
authors.forename: A C
authors.initials: AC
authors.lastname: Hackney
authors.affiliation: CIAFEL-Research Centre in Physical Activity, Health and Leisure, Faculty of Sport, University of Porto, Porto, Portugal.
authors.forename: J
authors.initials: J
authors.lastname: Mota
authors.affiliation: Centro de Estudios para la Medición de la Actividad Física «CEMA», Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá D.C., Colombia.
authors.forename: R
authors.initials: R
authors.lastname: Ramírez-Vélez
mesh_terms: D054392:Adipokines / Q000378:metabolism*; D052242:Adiponectin / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism; D002648:Child; D015444:Exercise; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D063766:Pediatric Obesity / Q000378:metabolism* / Q000503:physiopathology / Q000517:prevention & control; D016032:Randomized Controlled Trials as Topic
chemical_list: C499918:ADIPOQ protein, human; D054392:Adipokines; D052242:Adiponectin; D001786:Blood Glucose