title: Urinary Cross-linked N-terminal Telopeptide of Type I Collagen Levels of Infants with Osteogenesis Imperfecta and Healthy Infants.
abstract: The urinary cross-linked N-terminal telopeptide of type I collagen (uNTx) levels in infantile osteogenesis imperfecta (OI) have not been well studied. Here we investigated the levels of uNTx in infants with OI and healthy infants. We collected spot urine samples from 30 infants with OI (male/female, 14/16; Sillence classification, I/II/III/IV: 15/3/6/6; age, 5.2±4.4 months) and 120 healthy infants (male/female, 75/45; age, 5.1±4.1 months) for the measurement of uNTx levels. The uNTx levels of the OI infants were significantly lower than those of the healthy infants (mean±SD, 1,363.7±530.1 vs. 2,622.2±1,202.6 nmol BCE/mmol Cr; p＜0.001). The uNTx levels of the infants with type I OI were significantly lower than those of the age-matched healthy infants, although an overlap was observed between the 2 groups. Among the 1-month-old infants, the uNTx levels of the infants with types I, III or IV OI were significantly lower than those of the healthy infants, without overlap (1,622.5±235.8 vs. 3,781.0±1,027.1 nmol BCE/mmol Cr; p＜0.001). These results indicate that uNTx levels are significantly lower in infants with OI than in healthy infants, and they suggest that uNTx might be useful as a reference for diagnosing OI.
authors.affiliation: Department of Pediatrics, Okayama University Hospital, Okayama 700-8558, Japan.
authors.forename: Miho
authors.initials: M
authors.lastname: Yamashita
authors.forename: Kosei
authors.initials: K
authors.lastname: Hasegawa
authors.forename: Yousuke
authors.initials: Y
authors.lastname: Higuchi
authors.forename: Takayuki
authors.initials: T
authors.lastname: Miyai
authors.forename: Ayumi
authors.initials: A
authors.lastname: Okada
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tanaka
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Tsukahara
mesh_terms: D015415:Biomarkers; D001862:Bone Resorption / Q000378:metabolism / Q000652:urine; D001842:Bone and Bones / Q000378:metabolism; D016022:Case-Control Studies; D024042:Collagen Type I / Q000652:urine*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010013:Osteogenesis Imperfecta / Q000378:metabolism / Q000652:urine*; D010455:Peptides / Q000652:urine*; D012621:Seasons
chemical_list: D015415:Biomarkers; D024042:Collagen Type I; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide