title: The Multiple Roles of Exosomes in Metastasis.
abstract: Exosomes are important contributors to cell-cell communication and their role as diagnostic markers for cancer and the pathogenesis for cancer is under intensive investigation. Here, we focus on their role in metastasis-related processes. We discuss their impact regarding promotion of invasion and migration of tumor cells, conditioning of lymph nodes, generation of premetastatic niches and organotropism of metastasis. Furthermore, we highlight interactions of exosomes with bone marrow and stromal components such as fibroblasts, endothelial cells, myeloid- and other immune-related cells in the context of metastases. For all processes as described above, we outline molecular and cellular components for therapeutic intervention with metastatic processes.
authors.affiliation: Roche Innovation Center Munich, Roche Diagnostics GmbH, Penzberg, Germany.
authors.forename: Ulrich H
authors.initials: UH
authors.lastname: Weidle
authors.affiliation: Roche Innovation Center Basel, F. Hoffman La-Roche, Basel, Switzerland.
authors.forename: Fabian
authors.initials: F
authors.lastname: Birzele
authors.affiliation: Roche Innovation Center Munich, Roche Diagnostics GmbH, Penzberg, Germany.
authors.forename: Gwen
authors.initials: G
authors.lastname: Kollmorgen
authors.affiliation: Roche Innovation Center Munich, Roche Diagnostics GmbH, Penzberg, Germany ruediger.rueger@roche.com.
authors.forename: Rüdiger
authors.initials: R
authors.lastname: Rüger
mesh_terms: D017667:Adipocytes / Q000378:metabolism; D000818:Animals; D001253:Astrocytes / Q000378:metabolism; D002450:Cell Communication; D002465:Cell Movement; D004195:Disease Models, Animal; D042783:Endothelial Cells / Q000378:metabolism; D055354:Exosomes / Q000378:metabolism*; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism; D008175:Lung Neoplasms / Q000378:metabolism / Q000556:secondary; D008198:Lymph Nodes / Q000378:metabolism / Q000473:pathology; D008545:Melanoma / Q000378:metabolism / Q000473:pathology; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology*; D017154:Stromal Cells / Q000378:metabolism; D059016:Tumor Microenvironment
chemical_list: C112697:CD44v6 antigen; D018960:Hyaluronan Receptors
keywords: Exosome interaction with stromal cells; organ tropism of metastasis; pre- and metastatic niche; review