title: Proteomic peptide scan of porphyromonas gingivalis fima type ii for searching potential b-cell epitopes.
abstract: OBJECTIVE
  To identify potential antigenic targets for Porphyromonas gingivalis vaccine development.
  
  
  METHODS
  In the present study, we analyzed the Porphyromonas gingivalis, fimA type II primary amino acid sequence and characterized the similarity to the human proteome at the pentapeptide level.
  
  
  RESULTS
  We found that exact peptide-peptide profiling of the fimbrial antigenversusthe human proteome shows that only 19 out of 344 fimA type II pentapeptides are uniquely owned by the bacterial protein.
  
  
  CONCLUSIONS
  The concept that protein immunogenicity is allocated in rare peptide sequences and the search the Porphyromonas gingivalis fimA type II sequence for peptides unique to the bacterial protein and absent in the human host, might be used in new therapeutical approaches as a significant adjunct to current periodontal therapies.
authors.affiliation: Multidisciplinary Department of Medical-Surgical and Odontostomatological Specialties, Second University of Naples SUN, Naples, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Lucchese
authors.affiliation: Postgraduate School in Oral Surgery, Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples "Federico II", Naples, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Guida
authors.affiliation: Department of Biosciences, Biotechnologies and Pharmacological Sciences, University of Bari, Bari, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Capone
authors.affiliation: Department of Experimental Medicine, Section of Microbiology and Clinical Microbiology, Second University of Naples, Naples, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Donnarumma
authors.affiliation: Multidisciplinary Department of Medical-Surgical and Odontostomatological Specialties, Second University of Naples SUN, Naples, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Laino
authors.affiliation: Interdisciplinary Department of Medicine (DIM) - Section of Dentistry, University "Aldo Moro" of Bari, Bari, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Petruzzi
authors.affiliation: Multidisciplinary Department of Medical-Surgical and Odontostomatological Specialties, Second University of Naples SUN, Naples, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Serpico
authors.affiliation: Departimento de Estomatologia, University of Valencia, Valencia, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Silvestre
authors.affiliation: Department of Clinical Sciences And Translational Medicine, University of Rome "Tor Vergata", Rome, Italy; Department of dentistry "Fra G.B. Orsenigo - Ospedale San Pietro F.B.F.", Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Gargari
keywords: bacterial versus human peptide overlap; low-similarity peptides; peptide vaccine; periodontitis