title: Chiral Nanoparticle as a New Efficient Antimicrobial Nanoagent.
abstract: d-type functionalized nanoparticles (NPs) can bind to MurD ligase with high affinity and inhibit its peptidoglycan synthetic enzyme activity, and finally cause bacterial killing. In contrast, its L-type counterpart displays a negligible effect, indicating that the chiral structure of the functionalized NPs plays an essential role in their binding interaction with MurD and therefore the antibacterial activity.
authors.affiliation: CAS Center of Excellence for Nanoscience, CAS Key Laboratory for Nanosystem and Hierarchical Fabrication, National Center for Nanoscience and Technology, 11 Beiyitiao Zhongguancun, Beijing, 100190, P. R. China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Xin
authors.affiliation: CAS Center of Excellence for Nanoscience, CAS Key Laboratory for Nanosystem and Hierarchical Fabrication, National Center for Nanoscience and Technology, 11 Beiyitiao Zhongguancun, Beijing, 100190, P. R. China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Liu
authors.affiliation: CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, 11 Beiyitiao Zhongguancun, Beijing, 100190, P. R. China.
authors.forename: Lingling
authors.initials: L
authors.lastname: Geng
authors.affiliation: CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, 11 Beiyitiao Zhongguancun, Beijing, 100190, P. R. China.
authors.forename: Qiaojun
authors.initials: Q
authors.lastname: Fang
authors.affiliation: CAS Center of Excellence for Nanoscience, CAS Key Laboratory for Nanosystem and Hierarchical Fabrication, National Center for Nanoscience and Technology, 11 Beiyitiao Zhongguancun, Beijing, 100190, P. R. China.
authors.forename: Jian Ru
authors.initials: JR
authors.lastname: Gong
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D004926:Escherichia coli / Q000254:growth & development*; D053758:Nanoparticles / Q000737:chemistry*; D010453:Peptide Synthases / Q000737:chemistry / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000254:growth & development*
chemical_list: D000890:Anti-Infective Agents; D010453:Peptide Synthases; C053379:UDP-N-acetylmuramoylalanine-D-glutamate ligase
keywords: antimicrobial; chirality; graphene quantum dots; nanoparticles; selective toxicity