title: Nanotechnology in Neuroscience and its Perspective as Gene Carrier.
abstract: Gene therapy has a strong potential in neuroscience by suppressing or replacing abnormalities in genetic materials. The employment of nano-gene carrier for neurological disorders is comparatively young and restricted since the aim to effectively deliver therapeutic agents into the central nervous system (CNS) commonly has confronted difficulties of several natural occurring barriers in the body and unfavorable characteristics of pharmaceutical agents. Two major anatomical and biochemical barriers are blood-brain barrier (BBB) and blood-cerebrospinal fluid barrier (BCSFB), which significantly prevent permeation of most drugs and genes to brain parenchyma. In this concern, nanotechnology emerges as an innovative method for transporting therapeutics to the CNS. Diverse nano-systems have been closely investigated, some of which have demonstrated initial success for in vivo studies. The perspectives of nanotechnology for gene therapy would be a promising field to be further explored in the near future.
authors.affiliation: University of Connecticut. United States.
authors.forename: T M T
authors.initials: TMT
authors.lastname: Khanh
authors.affiliation: School of Medicine, Deakin University, Waurn Ponds, Victoria. Australia.
authors.forename: D
authors.initials: D
authors.lastname: Wei
authors.affiliation: School of Medicine, Deakin University, Waurn Ponds, Victoria. Australia.
authors.forename: P H L
authors.initials: PHL
authors.lastname: Tran
authors.affiliation: Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City. Vietnam.|Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Vietnam.
authors.forename: Thao T D
authors.initials: TTD
authors.lastname: Tran
mesh_terms: D002490:Central Nervous System / Q000187:drug effects; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D018014:Gene Transfer Techniques; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology; D009488:Neurosciences
chemical_list: D004337:Drug Carriers
keywords: Nanoparticles; blood-brain barrier; gene therapy; neurological disorders