title: Avascular Necrosis of the Hips With Increased Activity on 68Ga-DOTATATE PET/CT.
abstract: Prolonged exposure to cortisol is one of the major causes of avascular bone necrosis (AVN). We report on a case of a woman with Cushing syndrome attributed to ectopic adrenocorticotropic hormone-secreting tumor who was evaluated with whole-body PET/CT study using Ga-DOTATATE. The scan showed increased activity by both femoral heads, corresponding to the margins of bilateral AVN seen on MRI. The presented data suggests AVN-induced reactive inflammatory alterations adjacent to the necrotic segment of the bone, which can be effectively targeted using radiolabeled somatostatin (SST) analogs.
authors.affiliation: From the *Radiology and Imaging Sciences, Warren Grant Magnuson Clinical Center (CC), Bethesda; †PET Department, Clinical Center, National Institutes of Health (NIH), Bethesda, MD; ‡Department of Radiology, Medical School, University of Crete, Crete, Greece; and §Center for Research in Computer Vision (CRCV), Electrical and Computer Science Department, University of Central Florida (UCF), Orlando, FL.
authors.forename: Georgios Z
authors.initials: GZ
authors.lastname: Papadakis
authors.forename: Corina
authors.initials: C
authors.lastname: Millo
authors.forename: Apostolos H
authors.initials: AH
authors.lastname: Karantanas
authors.forename: Ulas
authors.initials: U
authors.lastname: Bagci
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Patronas
mesh_terms: D005260:Female; D006615:Hip / Q000000981:diagnostic imaging; D006801:Humans; D006854:Hydrocortisone / Q000009:adverse effects; D008875:Middle Aged; D009942:Organometallic Compounds; D010020:Osteonecrosis / Q000000981:diagnostic imaging* / Q000209:etiology; D000072078:Positron Emission Tomography Computed Tomography; D019275:Radiopharmaceuticals
chemical_list: D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; C513399:gallium Ga 68 dotatate; D006854:Hydrocortisone