title: The effects of thyroid function on retinopathy of prematurity.
abstract: OBJECTIVE
  To assess whether TSH and fT4 have a role in the angiogenesis of vaso-obliteration and neovascularization which are the basic pathophysiology of ROP.
  
  
  METHODS
  In this retrospective case-control study, the control group (n = 56) included preterm newborns with risk for ROP while the laser group (n = 63) was recruited from cases who developed severe neovascularization and needed laser photocoagulation therapy. Considering the first (vaso-obliteration) and second (neovascularization) phases of the disease, in this study we researched the distribution of thyroid function tests between groups.
  
  
  RESULTS
  With regard to the first phase of the disease, TSH and fT4 showed no significant differences between the control and laser groups accordingly (P > 0.05). Likewise, in the second phase of ROP, there was no significant difference between the control and laser groups with respect to TSH and fT4 levels (P > 0.05).
  
  
  CONCLUSIONS
  We found that between the study groups, the levels of thyroid function tests did not have any significant differences, either in the first or the second phases of ROP which are the principal pathophysiology of the disease. Therefore, it was concluded that thyroid hormone values were not informative markers in the course of the disease in preterm babies at risk of developing ROP.
authors.affiliation: Division of Neonatology, Department of Pediatrics, Erciyes University Medical Faculty, Kayseri, Turkey.
authors.forename: Levent
authors.initials: L
authors.lastname: Korkmaz
authors.affiliation: Division of Neonatology, Department of Pediatrics, Erciyes University Medical Faculty, Kayseri, Turkey.
authors.forename: Osman
authors.initials: O
authors.lastname: Baştuğ
authors.affiliation: Bozok University, Faculty of Medicine, Department of Pediatrics, Yozgat, Turkey.
authors.forename: Ghaniya
authors.initials: G
authors.lastname: Daar
authors.affiliation: Division of Neonatology, Department of Pediatrics, Erciyes University Medical Faculty, Kayseri, Turkey.
authors.forename: Sabriye
authors.initials: S
authors.lastname: Korkut
authors.affiliation: Division of Neonatology, Department of Pediatrics, Erciyes University Medical Faculty, Kayseri, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Özdemir
authors.affiliation: Division of Neonatology, Department of Pediatrics, Erciyes University Medical Faculty, Kayseri, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Adnan Öztürk
authors.affiliation: Division of Neonatology, Department of Pediatrics, Erciyes University Medical Faculty, Kayseri, Turkey.
authors.forename: Tamer
authors.initials: T
authors.lastname: Güneş
authors.affiliation: Division of Neonatology, Department of Pediatrics, Erciyes University Medical Faculty, Kayseri, Turkey.|Division of Pediatric Endocrinology, Erciyes University Medical Faculty, Kayseri, Turkey.
authors.forename: Selim
authors.initials: S
authors.lastname: Kurtoğlu
mesh_terms: D001997:Bronchopulmonary Dysplasia / Q000453:epidemiology; D016022:Case-Control Studies; D015897:Comorbidity; D005260:Female; D006801:Humans; D062071:Infant, Extremely Premature; D007231:Infant, Newborn; D007234:Infant, Premature; D017075:Laser Coagulation; D008297:Male; D012127:Respiratory Distress Syndrome, Newborn / Q000453:epidemiology; D012178:Retinopathy of Prematurity / Q000097:blood* / Q000453:epidemiology / Q000601:surgery; D012189:Retrospective Studies; D013961:Thyroid Gland / Q000378:metabolism; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000097:blood*
chemical_list: D013972:Thyrotropin; D013974:Thyroxine
keywords: Retinopathy of prematurity; thyroid stimulating hormone; thyroxine; vascular endothelial growth factor