title: Associations of serum fibroblast growth factor 23 levels with obesity and visceral fat accumulation.
abstract: Recent findings raise the possibility that fibroblast growth factor (FGF) 23 may be related with fat contents and distribution. The present study aimed to elucidate the associations of serum FGF23 levels with the fat contents and distribution.
  
  
  
  A total of 1599 normoglycemic individuals with preserved kidney function were enrolled. Serum levels of intact FGF23 were detected using a sandwich enzyme-linked immunosorbent assay. Overweight/obesity was defined by a body mass index of ≥25.0 kg/m2. Visceral fat area (VFA) was assessed by magnetic resonance imaging, and abdominal obesity was defined as VFA ≥80 cm2.
  
  
  
  Among the study population of 597 men, 411 premenopausal women, and 591 postmenopausal women, serum FGF23 levels were significantly increased in participants with overweight/obesity and abdominal obesity, respectively (both P < 0.001). Each one-unit increase in VFA was associated with a 0.028-pg/mL increase in serum FGF23 levels in men (P = 0.001) and a 0.051-pg/mL increase in serum FGF23 levels in postmenopausal women (P < 0.001). Whether in the presence of overweight/obesity or not, the presence of abdominal obesity was independently associated with the increase in serum FGF23 levels in men and postmenopausal women (all P < 0.05).
  
  
  
  Serum FGF23 levels are elevated in obese individuals, especially those with abdominal obesity. The independent associations between the presence of abdominal obesity and the increase in serum FGF23 levels in specific groups suggest that serum FGF23 levels may indicate the risk of metabolic and cardiovascular disease in men and postmenopausal women.
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China; Shanghai Clinical Center for Diabetes, Shanghai 200233, China; Shanghai Key Clinical Center for Metabolic Disease, Shanghai 200233, China; Shanghai Diabetes Institute, Shanghai 200233, China; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Hu
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China; Shanghai Clinical Center for Diabetes, Shanghai 200233, China; Shanghai Key Clinical Center for Metabolic Disease, Shanghai 200233, China; Shanghai Diabetes Institute, Shanghai 200233, China; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China.
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Ma
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China; Shanghai Clinical Center for Diabetes, Shanghai 200233, China; Shanghai Key Clinical Center for Metabolic Disease, Shanghai 200233, China; Shanghai Diabetes Institute, Shanghai 200233, China; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China.
authors.forename: Yuqi
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China; Shanghai Clinical Center for Diabetes, Shanghai 200233, China; Shanghai Key Clinical Center for Metabolic Disease, Shanghai 200233, China; Shanghai Diabetes Institute, Shanghai 200233, China; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China.
authors.forename: Yiting
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China; Shanghai Clinical Center for Diabetes, Shanghai 200233, China; Shanghai Key Clinical Center for Metabolic Disease, Shanghai 200233, China; Shanghai Diabetes Institute, Shanghai 200233, China; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Xiong
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China; Shanghai Clinical Center for Diabetes, Shanghai 200233, China; Shanghai Key Clinical Center for Metabolic Disease, Shanghai 200233, China; Shanghai Diabetes Institute, Shanghai 200233, China; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Pan
authors.affiliation: Department of Radiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
authors.forename: Yunfeng
authors.initials: Y
authors.lastname: Xiao
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China; Shanghai Clinical Center for Diabetes, Shanghai 200233, China; Shanghai Key Clinical Center for Metabolic Disease, Shanghai 200233, China; Shanghai Diabetes Institute, Shanghai 200233, China; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China. Electronic address: yqbao@sjtu.edu.cn.
authors.forename: Yuqian
authors.initials: Y
authors.lastname: Bao
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China; Shanghai Clinical Center for Diabetes, Shanghai 200233, China; Shanghai Key Clinical Center for Metabolic Disease, Shanghai 200233, China; Shanghai Diabetes Institute, Shanghai 200233, China; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China.
authors.forename: Weiping
authors.initials: W
authors.lastname: Jia
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000097:blood*; D006801:Humans; D050152:Intra-Abdominal Fat / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000453:epidemiology / Q000503:physiopathology; D055815:Young Adult
chemical_list: C000717427:FGF23 protein, human; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23
keywords: Abdominal obesity; Fibroblast growth factor 23; Visceral fat area