title: Reprogramming of glucose metabolism in hepatocellular carcinoma: Progress and prospects.
abstract: Hepatocellular carcinoma (HCC) is one of the most lethal cancers, and its rate of incidence is rising annually. Despite the progress in diagnosis and treatment, the overall prognoses of HCC patients remain dismal due to the difficulties in early diagnosis and the high level of tumor invasion, metastasis and recurrence. It is urgent to explore the underlying mechanism of HCC carcinogenesis and progression to find out the specific biomarkers for HCC early diagnosis and the promising target for HCC chemotherapy. Recently, the reprogramming of cancer metabolism has been identified as a hallmark of cancer. The shift from the oxidative phosphorylation metabolic pathway to the glycolysis pathway in HCC meets the demands of rapid cell proliferation and offers a favorable microenvironment for tumor progression. Such metabolic reprogramming could be considered as a critical link between the different HCC genotypes and phenotypes. The regulation of metabolic reprogramming in cancer is complex and may occurviagenetic mutations and epigenetic modulations including oncogenes, tumor suppressor genes, signaling pathways, noncoding RNAs, and glycolytic enzymesetc. Understanding the regulatory mechanisms of glycolysis in HCC may enrich our knowledge of hepatocellular carcinogenesis and provide important foundations in the search for novel diagnostic biomarkers and promising therapeutic targets for HCC.
authors.affiliation: Run-Ze Shang, Shi-Bin Qu, De-Sheng Wang, Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China.
authors.forename: Run-Ze
authors.initials: RZ
authors.lastname: Shang
authors.affiliation: Run-Ze Shang, Shi-Bin Qu, De-Sheng Wang, Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China.
authors.forename: Shi-Bin
authors.initials: SB
authors.lastname: Qu
authors.affiliation: Run-Ze Shang, Shi-Bin Qu, De-Sheng Wang, Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China.
authors.forename: De-Sheng
authors.initials: DS
authors.lastname: Wang
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000378:metabolism*; D044127:Epigenesis, Genetic; D016147:Genes, Tumor Suppressor; D005947:Glucose / Q000378:metabolism*; D006019:Glycolysis / Q000235:genetics*; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism*; D009154:Mutation; D009857:Oncogenes; D010085:Oxidative Phosphorylation; D022661:RNA, Untranslated; D015398:Signal Transduction
chemical_list: D022661:RNA, Untranslated; D005947:Glucose
keywords: Aerobic glycolysis; Glucose metabolism; Hepatocellular carcinoma; Metabolic reprogramming; Noncoding RNAs