title: Correlation of florbetaben PET imaging and the amyloid peptide Aß42 in cerebrospinal fluid.
abstract: Today, the use of biomarkers such as amyloid-specific positron emission tomography (PET) tracers and information derived from cerebrospinal fluid (CSF) can support the diagnosis of Alzheimer's disease (AD) as an indicator for the presence of amyloid pathology. We here show that the PET signal of the18F-labelled tracer florbetaben (NeuraCeq™), that binds to amyloid-beta plaques, inversely correlates with CSF levels of Aß42, another biomarker for AD. Results from the two biomarkers were concordant in 35 out of 38 subjects. In 7 AD subjects (20%) at least one biomarker was inconsistent with the clinical diagnosis. This confirms known limitations of the clinical AD diagnosis and highlights the potential of biomarker-assisted diagnosis to improve accuracy.
authors.affiliation: Charité-Universitätsmedizin Berlin, Experimental and Clinical Research Center - ECRC, Berlin, Germany; Charité-Universitätsmedizin Berlin, Institute of Neuropathology, Berlin, Germany. Electronic address: carola.schipke@charite.de.
authors.forename: Carola G
authors.initials: CG
authors.lastname: Schipke
authors.affiliation: Piramal Imaging GmbH, Berlin, Germany.
authors.forename: Norman
authors.initials: N
authors.lastname: Koglin
authors.affiliation: Piramal Imaging GmbH, Berlin, Germany.
authors.forename: Santiago
authors.initials: S
authors.lastname: Bullich
authors.affiliation: Department of Psychiatry, Charité-Campus Benjamin Franklin, Berlin, Germany.
authors.forename: Lisa Katharina
authors.initials: LK
authors.lastname: Joachim
authors.affiliation: Charité-Universitätsmedizin Berlin, Experimental and Clinical Research Center - ECRC, Berlin, Germany; Department of Psychiatry, Charité-Campus Benjamin Franklin, Berlin, Germany.
authors.forename: Brigitte
authors.initials: B
authors.lastname: Haas
authors.affiliation: Molecular NeuroImaging, LLC (MNI), New Haven, CT, USA.
authors.forename: John
authors.initials: J
authors.lastname: Seibyl
authors.affiliation: Leipzig University, Department of Nuclear Medicine, Leipzig, Germany.
authors.forename: Henryk
authors.initials: H
authors.lastname: Barthel
authors.affiliation: Leipzig University, Department of Nuclear Medicine, Leipzig, Germany.
authors.forename: Osama
authors.initials: O
authors.lastname: Sabri
authors.affiliation: Charité-Universitätsmedizin Berlin, Experimental and Clinical Research Center - ECRC, Berlin, Germany; Department of Psychiatry, Charité-Campus Benjamin Franklin, Berlin, Germany.
authors.forename: Oliver
authors.initials: O
authors.lastname: Peters
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid / Q000175:diagnosis; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid*; D000814:Aniline Compounds; D015415:Biomarkers / Q000134:cerebrospinal fluid; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D010446:Peptide Fragments / Q000134:cerebrospinal fluid*; D049268:Positron-Emission Tomography / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013267:Stilbenes
chemical_list: D016229:Amyloid beta-Peptides; D000814:Aniline Compounds; D015415:Biomarkers; D010446:Peptide Fragments; D013267:Stilbenes; C075222:amyloid beta-protein (1-42); C527756:4-(N-methylamino)-4'-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)stilbene
keywords: Alzheimer's disease; Beta-amyloid; Biomarker; Cerebrospinal fluid; Florbetaben; PET-tracer