title: Image-guided stereotactic radiosurgery for treatment of spinal hemangioblastoma.
abstract: OBJECTIVE Stereotactic radiosurgery (SRS) has been an attractive treatment option for hemangioblastomas, especially for lesions that are surgically inaccessible and in patients with von Hippel-Lindau (VHL) disease and multiple lesions. Although there has been a multitude of studies examining the utility of SRS in intracranial hemangioblastomas, SRS has only recently been used for spinal hemangioblastomas due to technical limitations. The purpose of this study is to provide a long-term evaluation of the effectiveness of image-guided radiosurgery in halting tumor progression and providing symptomatic relief for spinal hemangioblastomas. METHODS Between 2001 and 2011, 46 spinal hemangioblastomas in 28 patients were treated using the CyberKnife image-guided radiosurgery system at the authors' institution. Fourteen of these patients also had VHL disease. The median age at treatment was 43.5 years (range 19-85 years). The mean prescription radiation dose to the tumor periphery was 21.6 Gy (range 15-35 Gy). The median tumor volume was 0.264 cm3(range 0.025-70.9 cm3). Tumor response was evaluated on serial, contrast-enhanced CT and MR images. Clinical response was evaluated by clinical and imaging evaluation. RESULTS The mean follow-up for the cohort was 54.3 months. Radiographic follow-up was available for 19 patients with 34 tumors; 32 (94.1%) tumors were radiographically stable or displayed signs of regression. Actuarial control rates at 1, 3, and 5 years were 96.1%, 92.3%, and 92.3%, respectively. Clinical evaluation on follow-up was available for 13 patients with 16 tumors; 13 (81.2%) tumors in 10 patients had symptomatic improvement. No patient developed any complications related to radiosurgery. CONCLUSIONS Image-guided SRS is safe and effective for the primary treatment of spinal hemangioblastomas and is an attractive alternative to resection, especially for those with VHL disease.
authors.affiliation: Departments of 1 Neurosurgery and.
authors.forename: James
authors.initials: J
authors.lastname: Pan
authors.affiliation: Departments of 1 Neurosurgery and.
authors.forename: Allen L
authors.initials: AL
authors.lastname: Ho
authors.affiliation: Departments of 1 Neurosurgery and.
authors.forename: Myreille
authors.initials: M
authors.lastname: D'Astous
authors.affiliation: Departments of 1 Neurosurgery and.
authors.forename: Eric S
authors.initials: ES
authors.lastname: Sussman
authors.affiliation: Departments of 1 Neurosurgery and.
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Thompson
authors.affiliation: Departments of 1 Neurosurgery and.
authors.forename: Armine T
authors.initials: AT
authors.lastname: Tayag
authors.affiliation: Departments of 1 Neurosurgery and.
authors.forename: Louisa
authors.initials: L
authors.lastname: Pangilinan
authors.affiliation: Radiation Oncology, Stanford University School of Medicine, Stanford, California.
authors.forename: Scott G
authors.initials: SG
authors.lastname: Soltys
authors.affiliation: Radiation Oncology, Stanford University School of Medicine, Stanford, California.
authors.forename: Iris C
authors.initials: IC
authors.lastname: Gibbs
authors.affiliation: Departments of 1 Neurosurgery and.
authors.forename: Steven D
authors.initials: SD
authors.lastname: Chang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D018325:Hemangioblastoma / Q000000981:diagnostic imaging* / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016634:Radiosurgery / Q000379:methods*; D012189:Retrospective Studies; D013125:Spinal Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery*; D025321:Surgery, Computer-Assisted / Q000379:methods*; D016896:Treatment Outcome; D055815:Young Adult
keywords: ARE = adverse radiation event; CyberKnife; Dmax = maximum point dose; LINAC = linear accelerator; SRS = stereotactic radiosurgery; VHL = von Hippel-Lindau; hemangioblastoma; stereotactic radiosurgery; von Hippel-Lindau