title: Association between Polymorphism of Exportin-5 and Susceptibility to Lead Poisoning in a Chinese Population.
abstract: Lead (Pb) is one of the major contaminants in many industries, and imposes hazardous effects on multiple human organs and systems. Studies have shown that lead is able to induce the alteration of microRNA (miRNA) expression in serum and organs. In this study we investigated whether polymorphisms in miRNA-regulating genes were associated with the risk of lead exposure. We genotyped seven single-nucleotide polymorphisms (SNPs) in 113 lead-sensitive and 113 lead-resistant lead-related Chinese workers by Taqman analysis. The lead-sensitive group showed a significantly higher blood lead level (BLL) than the resistant group based on unconditional logistic regression results. One SNP inXPO5extron (rs2257082) was significantly associated with lead-poisoning (p= 0.022, odds rate (OR) = 1.63, 95% confidence interval (CI) = 1.07-2.47 in the C allele compared to the T allele). There were no significant associations between the other six SNPs and the blood lead levels. Therefore, polymorphism rs2257082 could be used to distinguish lead-resistant and lead-susceptible populations, and to develop more specific and accurate preventions.
authors.affiliation: Department of Toxicology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, No. 199 Renai Road, Suzhou Industrial Park, Suzhou 215123, China. hd-zhang@263.net.|Institute of Occupational Disease Prevention, Jiangsu Provincial Center for Disease Control and Prevention and Control, Nanjing 210028, China. hd-zhang@263.net.
authors.forename: Hengdong
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Institute of Occupational Disease Prevention, Jiangsu Provincial Center for Disease Control and Prevention and Control, Nanjing 210028, China. sosolou@126.com.
authors.forename: Ming
authors.initials: M
authors.lastname: Xu
authors.affiliation: School of Public Health, Southeast University, Nanjing 210009, China. firetadeas@foxmail.com.
authors.forename: Qiuni
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: Department of Emergency Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210009, China. sunkai1212@126.com.
authors.forename: Kai
authors.initials: K
authors.lastname: Sun
authors.affiliation: Institute of Occupational Disease Prevention, Jiangsu Provincial Center for Disease Control and Prevention and Control, Nanjing 210028, China. fat3760@163.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Gong
authors.affiliation: Institute of Occupational Disease Prevention, Jiangsu Provincial Center for Disease Control and Prevention and Control, Nanjing 210028, China. qycdc@163.com.
authors.forename: Qiaoyun
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Institute of Occupational Disease Prevention, Jiangsu Provincial Center for Disease Control and Prevention and Control, Nanjing 210028, China. zhbl5888@sina.com.cn.|School of Public Health, Southeast University, Nanjing 210009, China. zhbl5888@sina.com.cn.
authors.forename: Baoli
authors.initials: B
authors.lastname: Zhu
authors.affiliation: Department of Toxicology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, No. 199 Renai Road, Suzhou Industrial Park, Suzhou 215123, China. dranyan@126.com.
authors.forename: Yan
authors.initials: Y
authors.lastname: An
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D028884:Karyopherins / Q000235:genetics*; D007855:Lead Poisoning / Q000097:blood / Q000235:genetics*; D008297:Male; D035683:MicroRNAs / Q000235:genetics; D008875:Middle Aged; D009784:Occupational Diseases / Q000235:genetics; D016273:Occupational Exposure / Q000032:analysis; D020641:Polymorphism, Single Nucleotide; D012306:Risk
chemical_list: D028884:Karyopherins; D035683:MicroRNAs; C446511:XPO5 protein, human
keywords: XPO5 polymorphism; blood leads level; lead-sensitive and resistant; miRNA regulation