title: Pleiotropic effects of oxidized phospholipids.
abstract: Oxidized phospholipids (OxPLs) are increasingly recognized to play a role in a variety of normal and pathological states. OxPLs were implicated in regulation of inflammation, thrombosis, angiogenesis, endothelial barrier function, immune tolerance and other important processes. Rapidly accumulating evidence suggests that OxPLs are biomarkers of atherosclerosis and other pathologies. In addition, successful application of experimental drugs based on structural scaffold of OxPLs in animal models of inflammation was recently reported. This review briefly summarizes current knowledge on generation, methods of quantification and biological activities of OxPLs. Furthermore, receptor and cellular mechanisms of these effects are discussed. The goal of the review is to give a broad overview of this class of lipid mediators inducing pleiotropic biological effects.
authors.affiliation: Institute of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, University of Graz, Austria. Electronic address: valery.bochkov@uni-graz.at.
authors.forename: Valery
authors.initials: V
authors.lastname: Bochkov
authors.affiliation: Institute of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, University of Graz, Austria.
authors.forename: Bernd
authors.initials: B
authors.lastname: Gesslbauer
authors.affiliation: Institute of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, University of Graz, Austria.
authors.forename: Christina
authors.initials: C
authors.lastname: Mauerhofer
authors.affiliation: Signaling Laboratory, Department of Biomedicine, Basel University Hospital, Basel, Switzerland.
authors.forename: Maria
authors.initials: M
authors.lastname: Philippova
authors.affiliation: Signaling Laboratory, Department of Biomedicine, Basel University Hospital, Basel, Switzerland.
authors.forename: Paul
authors.initials: P
authors.lastname: Erne
authors.affiliation: Institute of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, University of Graz, Austria. Electronic address: o.oskolkova@uni-graz.at.
authors.forename: Olga V
authors.initials: OV
authors.lastname: Oskolkova
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D015415:Biomarkers / Q000378:metabolism; D004727:Endothelium / Q000276:immunology / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D007108:Immune Tolerance; D007249:Inflammation; D009389:Neovascularization, Pathologic / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D010084:Oxidation-Reduction; D010539:Permeability; D010743:Phospholipids / Q000737:chemistry / Q000145:classification / Q000276:immunology / Q000378:metabolism*; D049312:Receptors, Lysophospholipid / Q000235:genetics / Q000276:immunology; D013927:Thrombosis / Q000276:immunology / Q000378:metabolism* / Q000473:pathology
chemical_list: D015415:Biomarkers; D010743:Phospholipids; D049312:Receptors, Lysophospholipid
keywords: Analytics of oxidized phospholipids; Biological activities; Oxidized phospholipids; Receptors of oxidized phospholipids