title: Nutrigenomic Functions of PPARs in Obesogenic Environments.
abstract: Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that mediate the effects of several nutrients or drugs through transcriptional regulation of their target genes in obesogenic environments. This review consists of three parts. First, we summarize current knowledge regarding the role of PPARs in governing the development of white and brown/beige adipocytes from uncommitted progenitor cells. Next, we discuss the interactions of dietary bioactive molecules, such as fatty acids and phytochemicals, with PPARs for the modulation of PPAR-dependent transcriptional activities and metabolic consequences. Lastly, the effects of PPAR polymorphism on obesity and metabolic outcomes are discussed. In this review, we aim to highlight the critical role of PPARs in the modulation of adiposity and subsequent metabolic adaptation in response to dietary challenges and genetic modifications. Understanding the changes in obesogenic environments as a consequence of PPARs/nutrient interactions may help expand the field of individualized nutrition to prevent obesity and obesity-associated metabolic comorbidities.
authors.affiliation: Department of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE, USA.
authors.forename: Soonkyu
authors.initials: S
authors.lastname: Chung
authors.affiliation: Department of Food & Biotechnology, Korea University, Sejong, Republic of Korea.
authors.forename: Young Jun
authors.initials: YJ
authors.lastname: Kim
authors.affiliation: Department of Food and Nutrition, Seoul Women's University, Seoul, Republic of Korea.
authors.forename: Soo Jin
authors.identifier: 0000-0001-7892-7648
authors.initials: SJ
authors.lastname: Yang
authors.affiliation: Department of Food Science and Nutrition, Jeju National University, Jeju, Republic of Korea.
authors.forename: Yunkyoung
authors.identifier: 0000-0001-6453-769X
authors.initials: Y
authors.lastname: Lee
authors.affiliation: Department of Food and Nutrition and Research Institute of Obesity Science, Sungshin Women's University, Seoul, Republic of Korea.
authors.forename: Myoungsook
authors.identifier: 0000-0003-1344-6979
authors.initials: M
authors.lastname: Lee