title: Oral 30% glucose provides sufficient sedation in newborns during MRI.
abstract: OBJECTIVE
  Newborns are often sedated during MRI but sedation itself creates adverse events and management is more challenging in this environment. Oral glucose/sucrose administration has been studied in newborns during painful procedures; however, its effectiveness in keeping newborns sleepy and motionlessness during painless procedures has not been demonstrated. The objective of this study was to describe effectiveness of oral 30% glucose administration by comparing with intravenous midazolam sedation for newborns during MRI.
  
  
  METHODS
  One hundred twelve ASA II-III newborns who required care in the ICU and were scheduled for MRI with sedation were included. Group I received 30% glucose solution orally with 0.5-1 ml increments up to 2 ml/3 kg doses and group II received intravenous 0.1 mg/kg midazolam with 0.05 mg/kg repetition. The procedure was considered satisfactory when MRI images were not disturbed by patient movement after oral glucose or intravenous midazolam administration. The efficiency of the techniques, additional dose and rescue sedation requirements, blood glucose levels following oral 30% glucose suckling and presence of adverse events were recorded.
  
  
  RESULTS
  Demographic data was similar between groups. The efficiency of the procedures were similar between groups (78.9%, in group I and 66.1%, in group II). The blood glucose levels were within normal range in group I whereas transient desaturation and apnea occurred in 8 neonates in group II (p = 0.006).
  
  
  CONCLUSIONS
  Oral 30% glucose administration for newborns during MRI is as effective as standard sedation protocol with midazolam. Thereby, we recommend and support the integration of this safe and reliable technique into routine practice for newborns during MRI.
authors.affiliation: Department of Anesthesiology, Baskent University School of Medicine, Adana Research and Education Center, Dadaloglu Mah 4/A, 01250, Adana, Turkey. evreneker@yahoo.com.
authors.forename: H Evren
authors.identifier: http://orcid.org/0000-0002-7901-0185
authors.initials: HE
authors.lastname: Eker
authors.affiliation: Department of Anesthesiology, Baskent University School of Medicine, Adana Research and Education Center, Dadaloglu Mah 4/A, 01250, Adana, Turkey.
authors.forename: Oya Yalcin
authors.initials: OY
authors.lastname: Cok
authors.affiliation: Department of Pediatrics, Baskent University School of Medicine, Adana, Turkey.
authors.forename: Bilin
authors.initials: B
authors.lastname: Çetinkaya
authors.affiliation: Department of Anesthesiology, Baskent University School of Medicine, Adana, Turkey.
authors.forename: Anis
authors.initials: A
authors.lastname: Aribogan
mesh_terms: D000284:Administration, Oral; D000758:Anesthesia / Q000379:methods; D016292:Procedural Sedation / Q000379:methods; D004311:Double-Blind Method; D005260:Female; D005947:Glucose / Q000008:administration & dosage*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008874:Midazolam / Q000008:administration & dosage*; D011446:Prospective Studies
chemical_list: D006993:Hypnotics and Sedatives; D005947:Glucose; D008874:Midazolam
keywords: MRI; Newborns; Oral 30% glucose