title: Pyran Rings Containing Polyketides from Penicillium raistrickii.
abstract: Five new pyran rings containing polyketides, penicipyrans A-E (1-5), together with the known pestapyrone A (6), were isolated from the saline soil-derivedPenicillium raistrickii. Their structures were determined by interpretation of NMR and HRESIMS data. The absolute configurations of compounds4and5were established by the modified Mosher's method and single-crystal X-ray diffraction analysis, respectively. These compounds possessed high structural diversity including two α-pyrones (1,2), three isocoumarins (3,4,6), and one dihydropyran derivative (5). Among them, Compound5exhibited cytotoxicity against HL-60 and K562 cell lines with IC50values of 4.4 and 8.5 μM, respectively.
authors.affiliation: College of Pharmacy, Binzhou Medical College, Yantai 264003, China. maliyingbz@163.com.
authors.forename: Li-Ying
authors.initials: LY
authors.lastname: Ma
authors.affiliation: College of Pharmacy, Binzhou Medical College, Yantai 264003, China. desheng_liu@sina.com.
authors.forename: De-Sheng
authors.initials: DS
authors.lastname: Liu
authors.affiliation: The Hospital of Luzhong Mining Co., Ltd., Laiwu 271113, China. deguoli1983@sina.com.
authors.forename: De-Guo
authors.initials: DG
authors.lastname: Li
authors.affiliation: College of Pharmacy, Binzhou Medical College, Yantai 264003, China. huangyuling1979@163.com.
authors.forename: Yu-Ling
authors.initials: YL
authors.lastname: Huang
authors.affiliation: College of Pharmacy, Binzhou Medical College, Yantai 264003, China. kanghuihui_1993@126.com.
authors.forename: Hui-Hui
authors.initials: HH
authors.lastname: Kang
authors.affiliation: College of Pharmacy, Binzhou Medical College, Yantai 264003, China. chhwang77@163.com.
authors.forename: Chun-Hua
authors.initials: CH
authors.lastname: Wang
authors.affiliation: College of Pharmacy, Binzhou Medical College, Yantai 264003, China. lwz1963@163.com.
authors.forename: Wei-Zhong
authors.initials: WZ
authors.lastname: Liu
mesh_terms: D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray / Q000379:methods; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D018922:HL-60 Cells; D006801:Humans; D049934:Isocoumarins / Q000737:chemistry / Q000494:pharmacology; D020014:K562 Cells; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods; D010407:Penicillium / Q000737:chemistry*; D061065:Polyketides / Q000737:chemistry* / Q000494:pharmacology; D011714:Pyrans / Q000737:chemistry* / Q000494:pharmacology; D011753:Pyrones / Q000737:chemistry / Q000494:pharmacology; D014961:X-Ray Diffraction / Q000379:methods
chemical_list: D049934:Isocoumarins; D061065:Polyketides; D011714:Pyrans; D011753:Pyrones
keywords: Penicillium raistrickii; isocoumarin; polyketides; saline soil-derived fungus; α-pyrone