title: Organocatalytic Enantioselective Amination of 2-Substituted Indolin-3-ones: A Strategy for the Synthesis of Chiral α-Hydrazino Esters.
abstract: An efficient enantioselective α-amination of 2-substituted 3-indolinones has been achieved for the first time using hydroquinidine as a chiral catalyst through an aza-Michael reaction. The desired α-hydrazino esters are obtained in excellent yields with high enantiomeric excess leading to a quaternary stereocenter with a broad substrate scope.
authors.affiliation: Centre for Semiochemicals and ‡Laboratory of X-ray Crystallography, CSIR-Indian Institute of Chemical Technology , Hyderabad, 500 007, India.
authors.forename: Suresh
authors.initials: S
authors.lastname: Yarlagadda
authors.affiliation: Centre for Semiochemicals and ‡Laboratory of X-ray Crystallography, CSIR-Indian Institute of Chemical Technology , Hyderabad, 500 007, India.
authors.forename: B
authors.initials: B
authors.lastname: Ramesh
authors.affiliation: Centre for Semiochemicals and ‡Laboratory of X-ray Crystallography, CSIR-Indian Institute of Chemical Technology , Hyderabad, 500 007, India.
authors.forename: C
authors.initials: C
authors.lastname: Ravikumar Reddy
authors.affiliation: Centre for Semiochemicals and ‡Laboratory of X-ray Crystallography, CSIR-Indian Institute of Chemical Technology , Hyderabad, 500 007, India.
authors.forename: L
authors.initials: L
authors.lastname: Srinivas
authors.affiliation: Centre for Semiochemicals and ‡Laboratory of X-ray Crystallography, CSIR-Indian Institute of Chemical Technology , Hyderabad, 500 007, India.
authors.forename: B
authors.initials: B
authors.lastname: Sridhar
authors.affiliation: Centre for Semiochemicals and ‡Laboratory of X-ray Crystallography, CSIR-Indian Institute of Chemical Technology , Hyderabad, 500 007, India.
authors.forename: B V
authors.initials: BV
authors.lastname: Subba Reddy