title: Impact of Chronic Obstructive Pulmonary Disease on Long-Term Outcome in Patients with Coronary Artery Disease Undergoing Percutaneous Coronary Intervention.
abstract: Objective. The aim of this study was to investigate the association between COPD and major adverse cardiovascular and cerebral events (MACCE) in patients undergoing percutaneous coronary intervention (PCI).Methods. 2,362 patients who underwent PCI were included in this study. Subjects were divided into 2 groups: with COPD (n= 233) and without COPD (n= 2,129). Cox proportional hazards models were analyzed to determine the effect of COPD on the incidence of MACCE.Results. The patients with COPD were older (P< 0.0001) and were more likely to be current smokers (P= 0.02) and have had hypertension (P= 0.02) and diabetes mellitus (P= 0.01). Prevalence of serious cardiovascular comorbidity was higher in the patients with COPD, including a history of MI (P= 0.02) and HF (P< 0.0001). Compared with non-COPD group, the COPD group showed a higher risk of all-cause death (hazard ratio (HR): 2.45,P< 0.0001), cardiac death (HR: 2.53,P= 0.0002), MI (HR: 1.387,P= 0.027), and HF (HR: 2.25,P< 0.0001).Conclusions. Patients with CAD and concomitant COPD are associated with a higher incidence of MACCE (all-cause death, cardiac death, MI, and HF) compared to patients without COPD. The patients with a history of COPD have higher in-hospital and long-term mortality rates than those without COPD after PCI.
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
authors.forename: Ming
authors.identifier: 0000-0003-2956-4056
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, The Eastern Hospital of the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
authors.forename: Yun-Jiu
authors.initials: YJ
authors.lastname: Cheng
authors.affiliation: Department of Cardiology, Provincial Clinical Medical College, Fujian Medical University, Fuzhou, China.
authors.forename: Wei-Ping
authors.initials: WP
authors.lastname: Zheng
authors.affiliation: Department of Endocrinology, Tongji Hospital, Tongji University, Shanghai 200065, China.
authors.forename: Guang-Hui
authors.initials: GH
authors.lastname: Liu
authors.affiliation: Intensive Care Unit, Shenzhen People's Hospital, The Second Clinical Hospital of Jinan University, Guangzhou, China.
authors.forename: Huai-Sheng
authors.initials: HS
authors.lastname: Chen
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Ning
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of Biostatistics, School of Public Health, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA.
authors.forename: Li-Xiao
authors.initials: LX
authors.lastname: Su
authors.affiliation: Department of Cardiology, The Eastern Hospital of the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
authors.forename: Li-Juan
authors.identifier: 0000-0001-8068-8498
authors.initials: LJ
authors.lastname: Liu
mesh_terms: D000368:Aged; D003324:Coronary Artery Disease / Q000150:complications / Q000401:mortality / Q000503:physiopathology* / Q000601:surgery; D003643:Death; D003920:Diabetes Mellitus / Q000401:mortality / Q000503:physiopathology; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000401:mortality / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000401:mortality / Q000503:physiopathology; D062645:Percutaneous Coronary Intervention; D016016:Proportional Hazards Models; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000401:mortality / Q000503:physiopathology* / Q000601:surgery; D012307:Risk Factors; D016896:Treatment Outcome