title: Changes in Serum Concentrations of Fibroblast Growth Factor 23 and Soluble Klotho in Hemodialysis Patients after Total Parathyroidectomy.
abstract: Background. We examined the changes in circulating fibroblast growth factor 23 (FGF23) and Klotho concentrations in hemodialysis patients after parathyroidectomy (PTX).Methods. We enrolled a cohort of hemodialysis patients who received PTX. Postoperatively, patients received calcium supplements and/or vitamin D analogue (calcitriol) to maintain serum calcium within 7.0-8.0 mg/dL. Information on clinical parameters including bone-mineral metabolic variables was collected pre-PTX and on days 5 and 90 after PTX. Concomitantly, serum full-length FGF23 andα-Klotho levels were measured. The relationship between FGF23 and clinical parameters was analyzed by single linear regression.Results. Forty-six participants (33 women; 13 men) were enrolled in the study. Their mean age was 56.49 years. Serum FGF23 andα-Klotho concentrations were elevated on days 5 and 90 after PTX compared to baseline (p> 0.05). Serum FGF23 concentrations negatively correlated with serum calcium concentrations pre-PTX (Beta -0.31;R20.0949;p= 0.040), day 5 post-PTX (Beta -0.31;R20.0982;p= 0.036), and day 90 post-PTX (Beta -0.39;R20.1528;p= 0.008).Conclusions. There was no change in circulating FGF23 and Klotho concentrations after PTX in hemodialysis patients given postoperative calcium supplements and/or vitamin D analogue. Serum FGF23 concentrations pre-PTX and at days 5 and 90 after PTX were inversely related to serum calcium concentrations.
authors.affiliation: Division of Nephrology, Kaohsiung Municipal Feng-Shan Hospital, Kaohsiung, Taiwan.
authors.forename: Shang-Chih
authors.initials: SC
authors.lastname: Liao
authors.affiliation: Department of Electronic Engineering, National Kaohsiung University of Applied Sciences, Kaohsiung, Taiwan.
authors.forename: Sin-Hua
authors.identifier: 0000-0002-4082-1909
authors.initials: SH
authors.lastname: Moi
authors.affiliation: Department of Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
authors.forename: Fong-Fu
authors.initials: FF
authors.lastname: Chou
authors.affiliation: Department of Electronic Engineering, National Kaohsiung University of Applied Sciences, Kaohsiung, Taiwan.
authors.forename: Cheng-Hong
authors.initials: CH
authors.lastname: Yang
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
authors.forename: Jin-Bor
authors.identifier: 0000-0003-4007-1455
authors.initials: JB
authors.lastname: Chen
mesh_terms: D000368:Aged; D002117:Calcitriol / Q000008:administration & dosage; D005260:Female; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000097:blood*; D005966:Glucuronidase / Q000097:blood*; D006801:Humans; D006961:Hyperparathyroidism / Q000097:blood* / Q000209:etiology / Q000628:therapy; D000090265:Klotho Proteins; D008297:Male; D008875:Middle Aged; D016105:Parathyroidectomy; D006435:Renal Dialysis; D051436:Renal Insufficiency, Chronic / Q000097:blood* / Q000150:complications / Q000628:therapy; D013997:Time Factors
chemical_list: C000717427:FGF23 protein, human; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D005966:Glucuronidase; D000090265:Klotho Proteins; D002117:Calcitriol