title: [Analysis of clinical characteristics of perianal Crohn's disease in a single-center].
abstract: OBJECTIVE
  To discuss the clinical features of perianal Crohn disease (PCD).
  
  
  METHODS
  Clinical data of 52 PCD patients who were treated at the Department of Colorectal Surgery, Affiliated Hospital of Nanjing University of Chinese Medicine from June 2011 to October 2014 were analyzed retrospectively. Montreal classification, clinical symptoms, the subtype of perianal lesions, history of perianal surgery and medical treatment, disease active indexes, serum inflammation markers and nutritional indexes were included.
  
  
  RESULTS
  Among 52 patients, there were 40 males and 12 females with a mean age of (27.9±9.1) years. According to Montreal classification, 51.9%(27/52) of patients had ileocolic involvement and 75.0%(39/52) had inflammatory disease behavior. Thirteen (25.0%) and 15(28.8%) patients had abdominal pain and diarrhea respectively at admission. With respect to the subtype of perianal lesions, there were 32(61.5%) cases of anal fistula and 16(30.8%) cases of perianal abscess. Thirty-nine(75.0%) and 33(63.5%) patients had a history of perianal surgery and medical treatment before admission resepectively. Laboratory findings revealed high C-reaction protein level in 63.5%(33/52), high erythrocyte sedimentation rate in 61.5%(32/52), elevated platelet in 32.7%(17/52), low body weight in 44.2%(23/52), low albumin in 26.9%(14/52) and anemia in 42.3%(22/52) of patients.
  
  
  CONCLUSIONS
  The clinical features of PCD patients include male predominant, early onset disease, high prevalence of ileocolic involvement and inflammation disease behavior. Features prompting underlying PCD diagnosis include characteristic gastrointestinal symptoms, requiring multiple perianal surgery, and abnormality of inflammation markers and nutritional indexes.
authors.affiliation: First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210029, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Zhu
authors.affiliation: Department of Anorectal Surgery, Affiliated Hospital, Nanjing University of Chinese Medicine, Nanjing 210029, China.
authors.forename: Yugen
authors.initials: Y
authors.lastname: Chen
authors.affiliation: First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210029, China.
authors.forename: Yunfei
authors.initials: Y
authors.lastname: Gu
authors.affiliation: First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210029, China.
authors.forename: Hongjin
authors.initials: H
authors.lastname: Chen
authors.affiliation: First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210029, China.
authors.forename: Xiaohai
authors.initials: X
authors.lastname: An
authors.affiliation: First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210029, China.
authors.forename: Yingrui
authors.initials: Y
authors.lastname: Cheng
authors.affiliation: First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210029, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Department of Anorectal Surgery, Affiliated Hospital, Nanjing University of Chinese Medicine, Nanjing 210029, China. blyang1971@163.com.
authors.forename: Bolin
authors.initials: B
authors.lastname: Yang
mesh_terms: D015746:Abdominal Pain; D000038:Abscess; D000293:Adolescent; D000328:Adult; D001004:Anus Diseases; D003424:Crohn Disease; D003967:Diarrhea; D005260:Female; D006801:Humans; D008297:Male; D010502:Perineum; D012003:Rectal Fistula; D012189:Retrospective Studies; D055815:Young Adult