title: Clinical and viro-immunological correlates of HIV associated neurocognitive disorders (HAND) in a cohort of antiretroviral-naïve HIV-infected patients.
abstract: The multifactorial pathogenesis of HIV-associated neurocognitive disorders may explain the inconsistent association between neurocognitive impairment and cerebrospinal fluid (CSF) HIV RNA. Clinical and viro-immunological (CSF and plasma HIV RNA, CSF/plasma HIV RNA ratio, circulating T-cell phenotypes) parameters were investigated in 155 HIV-infected, antiretroviral-naïve, asymptomatic study participants undergoing a neuropsychological evaluation. HIV associated neurocognitive disorders (HAND) was independently associated with AIDS events and a CSF/plasma ratio of at least one, after adjustment for CD4 nadir of less than 200 cells/mmc, suggesting a role for active central nervous system (CNS) viral replication in the pathogenesis of neurocognitive impairment.
authors.affiliation: aDepartment of Health Sciences, Clinic of Infectious Diseases and Tropical Medicine, S.Paolo Hospital, ASST Santi Paolo e Carlo, University of Milan, Milan bDepartment of Health Sciences, Unit of Clinical Psychology, S.Paolo Hospital, ASST Santi Paolo e Carlo, University of Milan, Milan cDepartment of Medical Sciences, Clinic of Infectious and Tropical Diseases, Amedeo di Savoia Hospital, University of Turin, Turin, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Bai
authors.forename: Francesca
authors.initials: F
authors.lastname: Iannuzzi
authors.forename: Esther
authors.initials: E
authors.lastname: Merlini
authors.forename: Lidia
authors.initials: L
authors.lastname: Borghi
authors.forename: Camilla
authors.initials: C
authors.lastname: Tincati
authors.forename: Mattia
authors.initials: M
authors.lastname: Trunfio
authors.forename: Teresa
authors.initials: T
authors.lastname: Bini
authors.forename: Antonella d'Arminio
authors.initials: AD
authors.lastname: Monforte
authors.forename: Giulia
authors.initials: G
authors.lastname: Marchetti
mesh_terms: D015526:AIDS Dementia Complex / Q000473:pathology*; D000328:Adult; D015415:Biomarkers / Q000032:analysis*; D002555:Cerebrospinal Fluid / Q000821:virology; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D016130:Immunophenotyping; D008297:Male; D008875:Middle Aged; D010949:Plasma / Q000276:immunology / Q000821:virology; D012367:RNA, Viral / Q000032:analysis; D016176:T-Lymphocyte Subsets / Q000276:immunology; D019562:Viral Load
chemical_list: D015415:Biomarkers; D012367:RNA, Viral