title: Feasibility and clinical outcome after minimally invasive valve-sparing aortic root replacement.
abstract: This study aims to examine the feasibility and clinical course after minimally invasive David procedure compared with those via a conventional median sternotomy.
  
  
  
  One hundred and ninety-two consecutive patients who underwent elective valve-sparing aortic root replacement (David procedure) with or without additional cusp repair for aortic regurgitation ( n  = 17, 8.9%), dilatation of the aortic root ( n  = 95, 49.5%) or a combination of both pathologies ( n  = 80, 41.7%) were included. Patients with systemic disorders, such as Marfan's syndrome, and emergency cases were excluded. Assessment of quality of life was performed by modified Short Form Health Survey (SF-36) questionnaire. To minimize baseline differences, a matched pair analysis was conducted.
  
  
  
  One hundred and seventeen patients (60.9%) received a minimally invasive hemisternotomy (Group 1), 75 patients a conventional median sternotomy (39.1%, Group 2). Patients of Group 1 were significantly younger (56.5 ± 13.6 vs 64.8 ± 11.6, P  < 0.001). Understandably, concomitant cardiac procedures were more frequent in Group 2 ( n  = 7 [6.0%] vs n  = 48 [64.0%], P  < 0.001). In hospital, mortality was 0.9% in Group 1 (1/117) and 2.7% in Group 2 (2/75; P  = 0.562). Blood loss was significantly less in Group 1 (542.6 ± 441.8 vs 996.7 ± 822.6 ml, P  < 0.001). Duration of mechanical ventilation (10.2 ± 21.8 vs 26.9 ± 109.0 h, P  < 0.001) and ICU-stay (1.9 ± 3.6 vs 3.2 ± 5.6 days, P  < 0.001) were significantly shorter in the minimally invasive group, but this differences did not remain after matching. According to SF-36 questionnaire, patients in the minimally invasive group tend to have a higher quality of life.
  
  
  
  Minimally invasive valve-sparing aortic root replacement can be done safely via an upper partial sternotomy in experienced hands even if additional cusp repair is required.
authors.affiliation: Department of Cardiovascular Surgery, Robert-Bosch-Hospital, Stuttgart, Germany.
authors.forename: Kristina
authors.initials: K
authors.lastname: Wachter
authors.affiliation: Department of Cardiovascular Surgery, Robert-Bosch-Hospital, Stuttgart, Germany.
authors.forename: Ulrich F W
authors.initials: UF
authors.lastname: Franke
authors.affiliation: Department of Cardiac Surgery, Royal Brompton Hospital, London, United Kingdom.
authors.forename: Rashmi
authors.initials: R
authors.lastname: Yadav
authors.affiliation: Department of Cardiovascular Surgery, Robert-Bosch-Hospital, Stuttgart, Germany.
authors.forename: Ragi
authors.initials: R
authors.lastname: Nagib
authors.affiliation: Department of Cardiovascular Surgery, Robert-Bosch-Hospital, Stuttgart, Germany.
authors.forename: Adrian
authors.initials: A
authors.lastname: Ursulescu
authors.affiliation: Department of Cardiovascular Surgery, Robert-Bosch-Hospital, Stuttgart, Germany.
authors.forename: Samir
authors.initials: S
authors.lastname: Ahad
authors.affiliation: Department of Cardiovascular Surgery, Robert-Bosch-Hospital, Stuttgart, Germany.
authors.forename: Hardy
authors.initials: H
authors.lastname: Baumbach
mesh_terms: D000328:Adult; D000368:Aged; D001013:Aorta, Thoracic / Q000601:surgery*; D001021:Aortic Valve / Q000601:surgery*; D001022:Aortic Valve Insufficiency / Q000601:surgery*; D005240:Feasibility Studies; D005260:Female; D005858:Germany / Q000453:epidemiology; D019918:Heart Valve Prosthesis Implantation / Q000379:methods*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D019060:Minimally Invasive Surgical Procedures / Q000379:methods*; D011183:Postoperative Complications / Q000453:epidemiology*; D015996:Survival Rate / Q000639:trends; D016896:Treatment Outcome
keywords: Aortic aneurysm; Aortic valve insufficiency; Minimally invasive surgical procedures; Quality of life; Thoracic