title: OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN PATIENTS WITH BEHÇET UVEITIS.
abstract: OBJECTIVE
  To describe optical coherence tomography angiography (OCTA) findings in eyes with Behçet uveitis (BU) and to compare these findings with those of fluorescein angiography (FA).
  
  
  METHODS
  Prospective, comparative, cross-sectional study. Patients presenting with clinically active BU involving the posterior segment were evaluated using FA, spectral domain optical coherence tomography (SD-OCT), and OCTA. Optical coherence tomography angiograms were reviewed and analyzed. Foveal avascular zone areas and vessel densities were also reported.
  
  
  RESULTS
  Twenty-five patients (44 eyes) were included. Perifoveal microvascular changes were more frequently observed on OCTA than on FA (95.5 vs 59.1%; P < 0.001). Disruption of the perifoveal capillary arcade, areas of retinal capillary nonperfusion/hypoperfusion, and perifoveal capillary abnormalities, including rarefied, dilated, or shunting vessels were observed more frequently using OCTA than FA (40.9 vs 25%; P = 0.039, 86.4 vs 34.1%; P < 0.001, and 84.1 vs 36.4%; P < 0.001, respectively). Areas of retinal capillary nonperfusion/hypoperfusion were more frequently observed in the deep than in the superficial capillary plexus (81.8 vs 63.6%; P = 0.039). Capillary abnormalities and disorganization of the normal architecture of the capillary network were more frequent in the deep than in the superficial capillary plexus (P < 0.001). Foveal avascular zone area was not significantly larger in eyes with BU than in control group in both the superficial and the deep capillary plexuses (0.4 vs 0.34 mm; P = 0.23 and 0.72 vs 0.53 mm; P = 0.053, respectively). Capillary vessel density was significantly lower in eyes with BU than in control group in the deep capillary plexus (13.7 vs 17.2 mm 21; P = 0.004).
  
  
  CONCLUSIONS
  OCTA allows better visualization and characterization of perifoveal microvascular changes than FA in eyes with active BU. The deep capillary plexus seemed to be more severely involved than the superficial capillary plexus.
authors.affiliation: *Department of Ophthalmology, Fattouma Bourguiba University Hospital, Faculty of Medicine, University of Monastir, Monastir, Tunisia; †Department of Ophthalmology, Créteil Hospital, University of Paris Est, Créteil, France; and ‡Odéon Ophthalmological Center, Paris, France.
authors.forename: Moncef
authors.initials: M
authors.lastname: Khairallah
authors.forename: Nesrine
authors.initials: N
authors.lastname: Abroug
authors.forename: Sana
authors.initials: S
authors.lastname: Khochtali
authors.forename: Anis
authors.initials: A
authors.lastname: Mahmoud
authors.forename: Bechir
authors.initials: B
authors.lastname: Jelliti
authors.forename: Gabriel
authors.initials: G
authors.lastname: Coscas
authors.forename: Marco
authors.initials: M
authors.lastname: Lupidi
authors.forename: Rim
authors.initials: R
authors.lastname: Kahloun
authors.forename: Salim
authors.initials: S
authors.lastname: Ben Yahia
mesh_terms: D000293:Adolescent; D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008297:Male; D055806:Microvessels / Q000000981:diagnostic imaging / Q000473:pathology; D008875:Middle Aged; D011446:Prospective Studies; D012171:Retinal Vessels / Q000000981:diagnostic imaging / Q000473:pathology; D041623:Tomography, Optical Coherence; D014605:Uveitis / Q000000981:diagnostic imaging / Q000473:pathology*; D055815:Young Adult