title: Nano-Micelle of Moringa Oleifera Seed Oil Triggers Mitochondrial Cancer Cell Apoptosis
abstract: Cancer, a worldwide epidemic disease with diverse origins, involves abnormal cell growth with the potential to
  invade other parts of the body. Globally, it is the main cause of mortality and morbidity. To overcome the drawbacks
  of the commercially available chemotherapies, natural products-loaded nano-composites are recommended to improve
  cancer targetability and decrease the harmful impact on normal cells. This study aimed at exploring the anti-cancer
  impacts of Moringa oleifera seed oil in its free- (MO) and nano-formulations (MOn) through studying whether it
  mechanistically promotes mitochondrial apoptosis-mediating cell death. Mitochondrial-based cytotoxicity and flow
  cytometric-based apoptosis analyses were performed on cancer HepG2, MCF7, HCT 116, and Caco-2 cell lines against
  normal kidney BHK-21 cell line. The present study resulted that MOn triggered colorectal cancer Caco-2 and HCT
  116 cytotoxicity via mitochondrial dysfunction more powerful than its free counterpart (MO). On the other side, MOn
  and MO remarkably induces HCT 116 mitochondrial apoptosis, while sparing normal BHK-21 cells with minimal
  cytotoxic effect. The present results concluded that nano-micelle of Moringa oleifera seed oil (MOn) can provide a
  novel therapeutic approach for colorectal and breast cancers via mitochondrial-mediated apoptosis, while sparing normal
  and even liver cancer cells a bit healthy or with minimal harmful effect. Intriguingly, MOn induced breast cancer not
  hepatocellular carcinoma cell death.
authors.affiliation: Hormones Department, Medical Research Division, National Research Centre, 12622 Cairo, Egypt. Email: ahmedchemia87@yahoo.com
authors.forename: Ahmed A
authors.initials: AA
authors.lastname: Abd-Rabou
authors.forename: Khairy M
authors.initials: KhM
authors.lastname: A Zoheir
authors.forename: Mohamed S
authors.initials: MS
authors.lastname: Kishta
authors.forename: Aziza B
authors.initials: AB
authors.lastname: Shalby
authors.forename: Mohamed I
authors.initials: MI
authors.lastname: Ezzo
keywords: Moringa oleifera; seed oil; Nano-micelle; mitochondrial apoptosis; cancer