title: Women With Polycystic Ovary Syndrome Have Comparable Hip Bone Geometry to Age-Matched Control Women.
abstract: Polycystic ovary syndrome (PCOS) is an endocrine disorder affecting women of reproductive age manifesting with polycystic ovaries, menstrual irregularities, hyperandrogenism, hirsutism, and insulin resistance. The oligomenorrhea and amenorrhea characteristic to PCOS are associated with low bone mineral density (BMD); conversely, the hyperandrogenism and hyperinsulinemia may elicit a protective effect on BMD. As bone geometric properties provide additional information about bone strength, the objective of this study was to compare measures of hip geometry in women with PCOS to a healthy female population. Using dual-energy X-ray absorptiometry, BMD and measures of hip geometry were determined in women with PCOS (n = 60) and healthy controls (n = 60) aged 18-35 years. Clinical biochemical measures were also determined in women with PCOS. Measures of hip geometry, including cross-sectional area, cross-sectional moment of inertia, subperiosteal width (SPW), and section modulus, were similar between groups following correction for body mass index (BMI) (all p > 0.05) with intertrochanter SPW significantly lower in women with PCOS (p < 0.05). BMI-corrected whole body BMD as well as the lumbar spine and regions of proximal femur were also comparable between groups. In women with PCOS, BMI-corrected correlations were found between insulin and femoral shaft SPW (r = 0.322, p < 0.05), glucose and femoral neck (r = 0.301, p < 0.05), and trochanter BMD (0.348, p < 0.05), as well as between testosterone and femoral neck BMD (0.376, p < 0.05) and narrow neck cross-sectional area (0.306, p < 0.05). This study demonstrates that women with PCOS may have compromised intertrochanter SPW while oligomenorrhea appears to have no detrimental effect on bone density or geometry in women with PCOS.
authors.affiliation: College of Pharmacy and Nutrition, University of Saskatchewan, 110 Science Place, Saskatoon, SK S7N 5C9, Canada.
authors.forename: Laura E
authors.initials: LE
authors.lastname: McBreairty
authors.affiliation: College of Pharmacy and Nutrition, University of Saskatchewan, 110 Science Place, Saskatoon, SK S7N 5C9, Canada.
authors.forename: Gordon A
authors.initials: GA
authors.lastname: Zello
authors.affiliation: College of Kinesiology, Physical Activity Complex, University of Saskatchewan, 87 Campus Drive, Saskatoon, SK S7N 5B2, Canada.
authors.forename: Julianne J
authors.initials: JJ
authors.lastname: Gordon
authors.affiliation: Obstetrics, Gynecology and Reproductive Sciences, College of Medicine, 103 Hospital Drive, Saskatoon, SK S7N 0W8, Canada.
authors.forename: Shani B
authors.initials: SB
authors.lastname: Serrao
authors.affiliation: Obstetrics, Gynecology and Reproductive Sciences, College of Medicine, 103 Hospital Drive, Saskatoon, SK S7N 0W8, Canada.
authors.forename: Roger A
authors.initials: RA
authors.lastname: Pierson
authors.affiliation: Obstetrics, Gynecology and Reproductive Sciences, College of Medicine, 103 Hospital Drive, Saskatoon, SK S7N 0W8, Canada.
authors.forename: Donna R
authors.initials: DR
authors.lastname: Chizen
authors.affiliation: College of Kinesiology, Physical Activity Complex, University of Saskatchewan, 87 Campus Drive, Saskatoon, SK S7N 5B2, Canada. Electronic address: phil.chilbeck@usask.ca.
authors.forename: Philip D
authors.initials: PD
authors.lastname: Chilibeck
mesh_terms: D015502:Absorptiometry, Photon; D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D015519:Bone Density; D016022:Case-Control Studies; D018483:Diaphyses / Q000000981:diagnostic imaging / Q000503:physiopathology; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging* / Q000503:physiopathology; D005270:Femur Head / Q000000981:diagnostic imaging / Q000503:physiopathology; D005272:Femur Neck / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D007328:Insulin / Q000097:blood; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000503:physiopathology; D011085:Polycystic Ovary Syndrome / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D013739:Testosterone / Q000097:blood; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D007328:Insulin; D013739:Testosterone
keywords: Bone mineral density; hip geometry; polycystic ovary syndrome