title: Facile and green synthesis of phytochemicals capped platinum nanoparticles and in vitro their superior antibacterial activity.
abstract: The increase in the severe infectious diseases and resistance of the majority of the bacterial pathogens to the available drug is a serious problem now a day. In order to overcome this problem it is necessary to develop new therapeutic agents which are non-toxic and more effective to inhibit these microbial pathogens. For this purpose the plant extract of highly active medicinal plant, Taraxacum laevigatum was used for the synthesis of platinum nanoparticles (PtNPs) to enhance its bio-activities. The surface plasmon resonance peak appeared at 283nm clearly represent the formation of PtNPs. The results illustrate that the bio-synthesized PtNPs were uniformly dispersed, small sized (2-7nm) and spherical in shape. The green synthesized PtNPs were characterized by UV-vis spectroscopy, XRD, TEM, SEM, EDX, DLS and FTIR. These nanoparticles were tested against gram positive bacteria (Bacillus subtilis) and gram negative bacteria (Pseudomonas aeruginosa). The bio-synthesized PtNPs were examined to be more effective against both of the bacteria. The results showed, that the zone of inhibition of PtNPs against P. aeruginosa was 15 (±0.5) mm and B. subtilis was 18 (±0.8) mm. The most significant outcome of this examination is that PtNPs exhibited strong antibacterial activity against P. aeruginosa and B. subtilis which have strong defensive system against several antibiotics.
authors.affiliation: State key laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, PR China; Institute of Chemical Sciences, Gomal University, D. I. Khan, KP, Pakistan.
authors.forename: Kamran
authors.initials: K
authors.lastname: Tahir
authors.affiliation: Institute of Chemical Sciences, Gomal University, D. I. Khan, KP, Pakistan.
authors.forename: Sadia
authors.initials: S
authors.lastname: Nazir
authors.affiliation: State key laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, PR China.
authors.forename: Aftab
authors.initials: A
authors.lastname: Ahmad
authors.affiliation: State key laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, PR China. Electronic address: bsli@mail.buct.edu.cn.
authors.forename: Baoshan
authors.initials: B
authors.lastname: Li
authors.affiliation: State key laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, PR China.
authors.forename: Arif Ullah
authors.initials: AU
authors.lastname: Khan
authors.affiliation: Department of Chemistry, University of Science and Technology, Bannu 28100, KP, Pakistan.
authors.forename: Zia Ul Haq
authors.initials: ZU
authors.lastname: Khan
authors.affiliation: State key laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, PR China.
authors.forename: Faheem Ullah
authors.initials: FU
authors.lastname: Khan
authors.affiliation: State key laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, PR China.
authors.forename: Qudrat Ullah
authors.initials: QU
authors.lastname: Khan
authors.affiliation: State key laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, PR China.
authors.forename: Abrar
authors.initials: A
authors.lastname: Khan
authors.affiliation: State key laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, PR China.
authors.forename: Aziz Ur
authors.initials: AU
authors.lastname: Rahman
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D066298:In Vitro Techniques; D053768:Metal Nanoparticles / Q000737:chemistry*; D008854:Microscopy, Electron; D064209:Phytochemicals / Q000138:chemical synthesis*; D010984:Platinum / Q000737:chemistry*; D013057:Spectrum Analysis; D014961:X-Ray Diffraction
chemical_list: D000900:Anti-Bacterial Agents; D064209:Phytochemicals; D010984:Platinum
keywords: Antibacterial activity; Green synthesis; Platinum nanoparticles; Taraxacum laevigatum