title: Thrombosis RelatedABO,F5,MTHFR,andFGGGene Polymorphisms in Morbidly Obese Patients.
abstract: Objective. Obesity is a well-known risk factor for thrombotic complications. The aim of the present study was to determine the frequency of thrombosis relatedABO,F5,MTHFR,andFGGgene polymorphisms in morbidly obese patients and compare them with the group of nonobese individuals.Methods. Gene polymorphisms were analyzed in 320 morbidly obese patients (BMI > 40 kg/m2) and 303 control individuals (BMI < 30 kg/m2) of European descent.ABOC>T (rs505922),F5C>G (rs6427196),MTHFRC>T (rs1801133), andFGGC>T (rs6536024) SNPs were genotyped by RT-PCR.Results. We observed a tendency forMTHFRrs1801133 TT genotype to be linked with morbid obesity when compared to CC genotype; however, the difference did not reach the significantPvalue (OR 1.84, 95% CI 0.83-4.05,P= 0.129). Overall, the genotypes and alleles of rs505922, rs6427196, rs1801133, and rs6536024 SNPs had similar distribution between morbidly obese and nonobese control individuals. Distribution of height and weight means among individuals carrying different rs505922, rs6427196, rs1801133, and rs6536024 genotypes did not differ significantly.Conclusions. Gene polymorphismsABOC>T (rs505922),F5C>G (rs6427196),MTHFRC>T (rs1801133), andFGGC>T (rs6536024) were not associated with height, weight, or morbid obesity among European subjects.
authors.affiliation: Department of Anesthesiology, Lithuanian University of Health Sciences, Eiveniu Str. 2, LT-50009 Kaunas, Lithuania.
authors.forename: Kristina
authors.initials: K
authors.lastname: Kupcinskiene
authors.affiliation: Institute for Digestive Research, Lithuanian University of Health Sciences, Eiveniu Str. 2, LT-50009 Kaunas, Lithuania.
authors.forename: Martyna
authors.initials: M
authors.lastname: Murnikovaite
authors.affiliation: Institute for Digestive Research, Lithuanian University of Health Sciences, Eiveniu Str. 2, LT-50009 Kaunas, Lithuania.
authors.forename: Greta
authors.initials: G
authors.lastname: Varkalaite
authors.affiliation: Institute for Digestive Research, Lithuanian University of Health Sciences, Eiveniu Str. 2, LT-50009 Kaunas, Lithuania.
authors.forename: Simonas
authors.initials: S
authors.lastname: Juzenas
authors.affiliation: Department of Anesthesiology, Lithuanian University of Health Sciences, Eiveniu Str. 2, LT-50009 Kaunas, Lithuania.
authors.forename: Darius
authors.initials: D
authors.lastname: Trepenaitis
authors.affiliation: Department of Gastroenterology, Lithuanian University of Health Sciences, Eiveniu Str. 2, LT-50009 Kaunas, Lithuania.
authors.forename: Ruta
authors.initials: R
authors.lastname: Petereit
authors.affiliation: Department of Surgery, Lithuanian University of Health Sciences, Eiveniu Str. 2, LT-50009 Kaunas, Lithuania.
authors.forename: Almantas
authors.initials: A
authors.lastname: Maleckas
authors.affiliation: Institute for Digestive Research, Lithuanian University of Health Sciences, Eiveniu Str. 2, LT-50009 Kaunas, Lithuania; Department of Gastroenterology, Lithuanian University of Health Sciences, Eiveniu Str. 2, LT-50009 Kaunas, Lithuania.
authors.forename: Juozas
authors.identifier: 0000-0002-8760-7416
authors.initials: J
authors.lastname: Kupcinskas
authors.affiliation: Department of Anesthesiology, Lithuanian University of Health Sciences, Eiveniu Str. 2, LT-50009 Kaunas, Lithuania.
authors.forename: Andrius
authors.identifier: 0000-0002-4048-3065
authors.initials: A
authors.lastname: Macas
mesh_terms: D000017:ABO Blood-Group System / Q000235:genetics*; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005165:Factor V / Q000235:genetics*; D005260:Female; D005340:Fibrinogen / Q000235:genetics*; D006801:Humans; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D009767:Obesity, Morbid / Q000097:blood / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D013927:Thrombosis / Q000235:genetics*
chemical_list: D000017:ABO Blood-Group System; D005165:Factor V; D005340:Fibrinogen; C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)