title: Incorporation of no-carrier added200,203Pb and200,201,202Tl in calcium alginate and hesperidin incorporated calcium alginate beads.
abstract: When radioisotopes are injected to human body, instantly free radicals are generated due to the interaction of ionizing radiation with water and fluids present in the body. The vehicle carrying radionuclides into human body should therefore be designed in a way which could also eliminate or reduce such possibilities. For the first time we have used free radical scavenger hesperidin, a polyphenolic compound having a benzo-γ-pyrone with a benzene ring moiety for extraction of no-carrier added (NCA)200,203Pb and200,201,202Tl. We have modified CA beads by incorporation of a polyphenol (hesperidin) (CA-Hes). This tailor made beads were characterized and tested for their efficacy towards extraction of no-carrier-added lead and thallium radioisotopes from 40MeV α particle irradiated Hg2Cl2target.
authors.affiliation: Department of Chemistry, University of Calcutta, 92, APC Road, Kolkata 700009, India.
authors.forename: Kangkana
authors.initials: K
authors.lastname: Sarkar
authors.affiliation: Chemical Sciences Division, Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata 700064, India. Electronic address: susanta.lahiri@saha.ac.in.
authors.forename: Susanta
authors.initials: S
authors.lastname: Lahiri
authors.affiliation: Department of Chemistry, University of Calcutta, 92, APC Road, Kolkata 700009, India.
authors.forename: Kamalika
authors.initials: K
authors.lastname: Sen
mesh_terms: D000464:Alginates / Q000008:administration & dosage; D004339:Drug Compounding / Q000379:methods; D020723:Glucuronic Acid / Q000008:administration & dosage; D006569:Hesperidin / Q000008:administration & dosage; D006603:Hexuronic Acids / Q000008:administration & dosage; D006801:Humans; D007856:Lead Radioisotopes / Q000008:administration & dosage* / Q000302:isolation & purification / Q000627:therapeutic use; D008855:Microscopy, Electron, Scanning; D011877:Radionuclide Imaging / Q000379:methods; D019275:Radiopharmaceuticals / Q000008:administration & dosage* / Q000302:isolation & purification / Q000627:therapeutic use; D013794:Thallium Radioisotopes / Q000008:administration & dosage* / Q000302:isolation & purification / Q000627:therapeutic use
chemical_list: D000464:Alginates; D006603:Hexuronic Acids; D007856:Lead Radioisotopes; C000615121:Lead-203; D019275:Radiopharmaceuticals; D013794:Thallium Radioisotopes; C000615113:Thallium-200; D020723:Glucuronic Acid; D006569:Hesperidin; C000615114:Thallium-201; C000615115:Thallium-202
keywords: (200),(203)Pb; (200,201,202)Tl; Calcium alginate; Extraction; Hesperidin