title: Safety and efficacy of intensity-modulated radiotherapy in the management of spermatic cord sarcoma.
abstract: OBJECTIVE
  Spermatic cord sarcoma is a rare disease, which management remains controversial due to the lack of guidelines. The standard therapeutic approach is surgical: wide soft-tissue resection with radical inguinal orchidectomy, The diagnosis is made during the analysis of the specimen. The high rate of local recurrence indicates adjuvant radiotherapy of the tumor bed. The aim of this series is to determine the efficacy and safety of postoperative intensity-modulated radiotherapy for spermatic cord sarcomas.
  
  
  METHODS
  Our series included five consecutive cases of spermatic cord sarcoma treated between 2011 and 2014. The indications for radiotherapy were: R1 status after initial surgery, R1 status after wide en bloc resection and orchiectomy, high French federation of cancer centers (FNCLCC) grade, tumor size over 5cm, tumor resection during surgery.
  
  
  RESULTS
  Median age at diagnosis was 66years (range 46-84years). Median follow-up was 18months (range 6-28months). Four patients had repeat surgery after incomplete removal. All surgeries were orchidectomy with primary ligation of testicular vessels. One patient did not have an in sano margin after the second surgical procedure. The median tumor size was 60mm (range 30-150mm). No recurrence was observed during the follow-up.
  
  
  CONCLUSIONS
  No grade 4 toxicities were reported and the most frequent acute toxicity was dermatitis. No recurrence was reported after adjuvant intensity-modulated radiotherapy. The treatment is feasible and well tolerated and seems to provide encouraging results regarding locoregional control of the disease. Dynamic or rotational intensity-modulated radiotherapy is now recommended to decrease acute toxicities while improving the efficacy of this approach.
authors.affiliation: Department of Radiation Oncology, CHU de Besançon, 3, boulevard Fleming, 25030 Besançon, France. Electronic address: tomcerd@gmail.com.
authors.forename: T
authors.initials: T
authors.lastname: Cerda
authors.affiliation: Department of Radiation Oncology, centre Georges-François-Leclerc, 1, rue du Professeur-Marion, 21000 Dijon, France.
authors.forename: É
authors.initials: É
authors.lastname: Martin
authors.affiliation: Department of Radiation Oncology, centre Georges-François-Leclerc, 1, rue du Professeur-Marion, 21000 Dijon, France.
authors.forename: G
authors.initials: G
authors.lastname: Truc
authors.affiliation: Department of Radiation Oncology, centre Georges-François-Leclerc, 1, rue du Professeur-Marion, 21000 Dijon, France; Medical Imaging group, laboratoire électronique, informatique et image (Le2I) UMR 6306, CNRS, allée Alain-Savary, 21000 Dijon, France; Le2I UMR 6306, Arts et Métiers, allée Alain-Savary, 21000 Dijon, France; Le2I UMR 6306, UFR Sciences et Techniques, université de Bourgogne-Franche-Comté, allée Alain-Savary, 21000 Dijon, France.
authors.forename: G
authors.initials: G
authors.lastname: Créhange
authors.affiliation: Department of Radiation Oncology, centre Georges-François-Leclerc, 1, rue du Professeur-Marion, 21000 Dijon, France.
authors.forename: P
authors.initials: P
authors.lastname: Maingon
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005500:Follow-Up Studies; D005834:Genital Neoplasms, Male / Q000532:radiotherapy* / Q000601:surgery; D006801:Humans; D007890:Leiomyosarcoma / Q000532:radiotherapy / Q000601:surgery; D008080:Liposarcoma / Q000532:radiotherapy* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009919:Orchiectomy; D058958:Organs at Risk; D011855:Radiodermatitis / Q000453:epidemiology / Q000209:etiology; D011879:Radiotherapy Dosage; D050397:Radiotherapy, Intensity-Modulated / Q000009:adverse effects / Q000379:methods; D012086:Reoperation; D012189:Retrospective Studies; D013085:Spermatic Cord; D016896:Treatment Outcome
keywords: Cordon spermatique; IMRT; Paratesticular tumor; RCMI; Radiotherapy; Radiothérapie; Sarcoma; Sarcome; Spermatic cord; Tumeur paratesticulaire