title: Application of optical coherence tomography angiography in assessment of posterior scleral reinforcement for pathologic myopia.
abstract: OBJECTIVE
  To investigate the effect of posterior scleral reinforcement (PSR) on circulation of pathologic myopia eyes with posterior staphyloma by optical coherence tomography angiography (OCTA).
  
  
  METHODS
  The study included 30 pathologic myopia eyes with posterior staphyloma which underwent PSR (PSR group) for 6 to 18mo ago, and 30 age and myopia matched eyes without PSR surgery as control group. Macular, choriocapillaris and radial peripapillary capillary (RPC) flow density were measured by OCTA, and the measurements were compared between groups.
  
  
  RESULTS
  OCTA found no significant differences in macular flow density between PSR and control groups. For the superficial flow, whole enface flow density (WED), fovea density (FD), and parafoveal density (PD) were 46.55%±5.19%vs47.29%±4.12% (P=0.542), 31.45%±6.35%vs31.17%±4.48% (P=0.841), and 48.82%±5.66%vs49.21%±4.15% (P=0.756) in PSR and control groups, respectively. For the deep flow, WED, FD, and PD were 52.07%±5.78%vs53.95%±4.62% (P=0.168), 29.62%±6.55%vs29.50%±6.38% (P=0.940), and 56.93%±6.17%vs58.15%±5.13% (P=0.407) in PSR and control groups, respectively. The choriocapillary flow density was 61.18±3.25% in PSR groupvs60.88%±2.56% in control group (P=0.692). Also, OCTA found no significant differences in RPCs flow density between PSR and control groups. The optic disc WED, inside disc flow density and peripapillary flow density were 48.47%±4.77%vs48.11%±4.57% (P=0.813), 45.47%±11.44%vs46.68%±9.02% (P=0.709), 54.32%±5.29%vs52.47%±6.62% (P=0.349) in PSR and control groups, respectively.
  
  
  CONCLUSIONS
  OCTA provides a non-invasive and quantitative approach for monitoring macular and papillary blood flow in pathologic myopia. PSR can not improve but may maintain the circulation of pathologic myopia eyes with posterior staphyloma.
authors.affiliation: Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Mo
authors.affiliation: Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
authors.forename: An-Li
authors.initials: AL
authors.lastname: Duan
authors.affiliation: Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
authors.forename: Szy-Yann
authors.initials: SY
authors.lastname: Chan
authors.affiliation: Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
authors.forename: Xue-Fei
authors.initials: XF
authors.lastname: Wang
authors.affiliation: Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China; Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing 100730, China.
authors.forename: Wen-Bin
authors.initials: WB
authors.lastname: Wei
keywords: optical coherence tomography angiography; pathologic myopia; posterior scleral reinforcement