title: Polyacetylenic Oleanane-Type Triterpene Saponins from the Roots of Panax japonicus.
abstract: Three new polyacetylenic oleanane-type triterpenoids, baisanqisaponins A-C (1-3), and one new oleanane-type triterpenoid, chikusetsusaponin-V ethyl ester (4), together with 19 known compounds (5-23), were isolated from the roots of Panax japonicus. The structures were elucidated on the basis of spectroscopic analyses and chemical methods. Compounds 1-3 feature a rare panaxytriol group containing a polyacetylene on the saponin skeleton. Neuroprotective activity was evaluated for compounds 1-17, and angiotensin II-induced vascular smooth muscle cell proliferation inhibition was tested for compounds 5-7 and 10-12.
authors.affiliation: TCM and Ethnomedicine Innovation & Development Laboratory, Sino-Luxemburg TCM Research Center, School of Pharmacy, Hunan University of Chinese Medicine , Changsha, 410208, People's Republic of China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.affiliation: National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, University of Mississippi , University, Mississippi 38677, United States.
authors.forename: Jianping
authors.initials: J
authors.lastname: Zhao
authors.affiliation: TCM and Ethnomedicine Innovation & Development Laboratory, Sino-Luxemburg TCM Research Center, School of Pharmacy, Hunan University of Chinese Medicine , Changsha, 410208, People's Republic of China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Chen
authors.affiliation: TCM and Ethnomedicine Innovation & Development Laboratory, Sino-Luxemburg TCM Research Center, School of Pharmacy, Hunan University of Chinese Medicine , Changsha, 410208, People's Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: TCM and Ethnomedicine Innovation & Development Laboratory, Sino-Luxemburg TCM Research Center, School of Pharmacy, Hunan University of Chinese Medicine , Changsha, 410208, People's Republic of China.
authors.forename: Bin
authors.initials: B
authors.lastname: Li
authors.affiliation: TCM and Ethnomedicine Innovation & Development Laboratory, Sino-Luxemburg TCM Research Center, School of Pharmacy, Hunan University of Chinese Medicine , Changsha, 410208, People's Republic of China.
authors.forename: Yuqing
authors.initials: Y
authors.lastname: Jian
authors.affiliation: Xinjiang Institute of Chinese Material Medica and Ethnomedicine , Urumqi, 830002, People's Republic of China.
authors.forename: Gulnar
authors.initials: G
authors.lastname: Sabir
authors.affiliation: TCM and Ethnomedicine Innovation & Development Laboratory, Sino-Luxemburg TCM Research Center, School of Pharmacy, Hunan University of Chinese Medicine , Changsha, 410208, People's Republic of China.
authors.forename: Shaowu
authors.initials: S
authors.lastname: Cheng
authors.affiliation: TCM and Ethnomedicine Innovation & Development Laboratory, Sino-Luxemburg TCM Research Center, School of Pharmacy, Hunan University of Chinese Medicine , Changsha, 410208, People's Republic of China.
authors.forename: Qinhui
authors.initials: Q
authors.lastname: Tuo
authors.affiliation: National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, University of Mississippi , University, Mississippi 38677, United States.
authors.forename: Ikhlas
authors.initials: I
authors.lastname: Khan
authors.affiliation: TCM and Ethnomedicine Innovation & Development Laboratory, Sino-Luxemburg TCM Research Center, School of Pharmacy, Hunan University of Chinese Medicine , Changsha, 410208, People's Republic of China.
authors.forename: Wei
authors.identifier: http://orcid.org/0000-0003-0876-2205
authors.initials: W
authors.lastname: Wang
mesh_terms: D000809:Angiotensins / Q000494:pharmacology; D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008297:Male; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D019906:Nuclear Magnetic Resonance, Biomolecular; D009828:Oleanolic Acid / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D016716:PC12 Cells; D005894:Panax / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry; D053279:Polyynes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000809:Angiotensins; D004365:Drugs, Chinese Herbal; D018696:Neuroprotective Agents; D012503:Saponins; C413246:oleanane; D053279:Polyynes; D009828:Oleanolic Acid