title: The Prevalence of Eosinophilic Esophagitis in Pediatric Patients with IgE-Mediated Food Allergy.
abstract: BACKGROUND
  Eosinophilic esophagitis (EoE) is an allergic inflammatory disease that is triggered by food allergens and characterized by progressive esophageal dysfunction. Recently, EoE has been identified in patients who underwent oral immunotherapy (OIT) for IgE-mediated food allergy, suggesting an association.
  
  
  OBJECTIVE
  We sought to ascertain whether significant associations exist between IgE-mediated food allergies and EoE.
  
  
  METHODS
  Using the analysis of electronic medical record data and manual chart review, we examined our subspecialty care network of 35,528 children and adolescents to identify and characterize patients with IgE-mediated and EoE food allergy. The most common food allergens were defined, and the prevalence of EoE in patients with IgE-mediated food allergy was determined. Logistic regression was used to measure the extent to which IgE-mediated food allergy to specific foods is associated with EoE.
  
  
  RESULTS
  The most common causes of EoE were milk, soy, egg, grains, and meats, an allergen pattern that is distinct from that of IgE-mediated food allergy. The prevalence of EoE in patients with IgE-mediated food allergy was higher than that reported in the general population (4.7% vs 0.04%). The distribution of IgE-mediated food allergens in patients with EoE was similar to that of the general population, and IgE-mediated allergy to egg (2.27; 1.91-2.64), milk (4.19; 3.52-4.97), or shellfish (1.55; 1.24-1.92) was significantly associated with an EoE diagnosis.
  
  
  CONCLUSIONS
  Our findings support a clinical association between these conditions that has implications for the management of children with food allergy, and particular relevance to patients undergoing OIT.
authors.affiliation: Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa; Division of Allergy and Immunology, The Children's Hospital of Philadelphia, Philadelphia, Pa.
authors.forename: David A
authors.initials: DA
authors.lastname: Hill
authors.affiliation: Department of Biomedical and Health Informatics, The Children's Hospital of Philadelphia, Philadelphia, Pa.
authors.forename: Jesse W
authors.initials: JW
authors.lastname: Dudley
authors.affiliation: Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa; Division of Allergy and Immunology, The Children's Hospital of Philadelphia, Philadelphia, Pa. Electronic address: spergel@email.chop.edu.
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Spergel
mesh_terms: D000293:Adolescent; D000485:Allergens / Q000276:immunology; D002648:Child; D015331:Cohort Studies; D003888:Desensitization, Immunologic; D057286:Electronic Health Records; D057765:Eosinophilic Esophagitis / Q000453:epidemiology*; D004947:Esophagus / Q000276:immunology*; D005260:Female; D005512:Food Hypersensitivity / Q000453:epidemiology*; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology*; D008297:Male; D015995:Prevalence; D014481:United States
chemical_list: D000485:Allergens; D007073:Immunoglobulin E
keywords: Eosinophilic esophagitis; Food allergy; IgE; Oral immunotherapy; Prevalence