title: Limited Accuracy of Colour Doppler Ultrasound Dynamic Tissue Perfusion Measurement in Diabetic Adults.
abstract: Dynamic tissue perfusion measurement (DTPM) is a pre-described and available method in pediatric ultrasound to quantify tissue perfusion in renal Doppler ultrasound by particular video analysis software. This study evaluates DTPM during single and between repeated visits after 6 months, calibrates repeated DTPM within different region of interest (ROI) and compares DTPM with kidney function markers in adult patients with early diabetic nephropathy (n = 17). During repeated measurements, no association of readings at the same patients in the same (n = 3 readings) as well as repeated visit (n = 2 visits) could be retrieved. No association between DTPM, MDRD-GFR, albuminuria, age and duration of diabetes was observed. These negative results are presumably related to inconsistency of DTPM due to non-fixed ROI position as could be shown in calibrating series. Further development of the method should be performed to enable reproducible DTPM readings in adults.
authors.affiliation: Dept. Nephrology and Kuratorium for Dialysis and Transplantation (KfH) Renal Unit Hospital St. Georg, Leipzig, Germany.
authors.forename: Felix
authors.initials: F
authors.lastname: Stoperka
authors.affiliation: Dept. Nephrology and Kuratorium for Dialysis and Transplantation (KfH) Renal Unit Hospital St. Georg, Leipzig, Germany.
authors.forename: Claudia
authors.initials: C
authors.lastname: Karger
authors.affiliation: Dept. Nephrology and Kuratorium for Dialysis and Transplantation (KfH) Renal Unit Hospital St. Georg, Leipzig, Germany.|Martin-Luther-University Halle/Wittenberg, Halle, Germany.
authors.forename: Joachim
authors.identifier: http://orcid.org/0000-0002-1907-825X
authors.initials: J
authors.lastname: Beige
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003928:Diabetic Nephropathies / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007668:Kidney / Q000098:blood supply / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D012039:Regional Blood Flow; D012680:Sensitivity and Specificity; D018615:Ultrasonography, Doppler, Color; D055815:Young Adult