title: High-sensitivity Troponin T Assay in Asymptomatic High Cardiovascular Risk Patients. The TUSARC Registry.
abstract: OBJECTIVE
  High-sensitivity troponin T assays (Hs-TnT) have been carried out in selected populations in clinical trials and in registries of the general population with low cardiovascular risk (CVR). The aim of this study was to determine the proportion of individuals with detectable Hs-TnT and the proportion of individuals with elevated Hs-TnT in a Spanish population of asymptomatic individuals with very high CVR, as well as the parameters associated with Hs-TnT elevation.
  
  
  METHODS
  The study included 690 patients. Hs-TnT detection and Hs-TnT elevation (≥99th percentile value), as well the association of elevated Hs-TnT and clinical, analytical, and treatment data were analyzed.
  
  
  RESULTS
  Hs-TnT was analyzed in 646 patients and was detected in 645. Elevated TnT was detected in 212 patients (32.9%). On multivariate analysis, elevated TnT was independently associated with male sex (OR, 2.81; 95%CI, 1.67-4.73; P < .001), older age (OR, 1.06; 95%CI, 1.04-1.09; P < .001), a higher body mass index (OR, 1.07; 95%CI, 1.02-1.12; P < .002), insulin therapy (OR, 1.99; 95%CI, 1.15-3.46; P = .01), history of heart failure (OR, 3.92; 95%CI, 1.24-12.39; P = .02), and estimated glomerular filtration rate calculated by CKD-EPI (OR, 0.96; 95%CI, 0.95-0.97; P < .001).
  
  
  CONCLUSIONS
  In a Spanish population of asymptomatic individuals at very high CVR, Hs-TnT was associated with older age, male sex, higher body mass index, insulin therapy, history of heart failure, and lower glomerular filtration rate.
authors.affiliation: Medicina Familiar y Comunitaria, Hospital Santos Reyes, Aranda de Duero, Burgos, Spain.
authors.forename: Isabel
authors.initials: I
authors.lastname: Álvarez
authors.affiliation: Servicio de Medicina Interna, Hospital Santos Reyes, Aranda de Duero, Burgos, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Hernández
authors.affiliation: Servicio de Cardiología, Hospital Santos Reyes, Aranda de Duero, Burgos, Spain.
authors.forename: Héctor
authors.initials: H
authors.lastname: García
authors.affiliation: Laboratorio de Análisis Clínicos, Hospital Santos Reyes, Aranda de Duero, Burgos, Spain.
authors.forename: Vicente
authors.initials: V
authors.lastname: Villamandos
authors.affiliation: Laboratorio de Análisis Clínicos, Hospital Central de la Defensa Gómez Ulla, Madrid, Spain.
authors.forename: María Gracia
authors.initials: MG
authors.lastname: López
authors.affiliation: Servicio de Cardiología, Hospital Central de la Defensa Gómez Ulla, Madrid, Spain.
authors.forename: Jorge
authors.initials: J
authors.lastname: Palazuelos Molinero
authors.affiliation: Servicio de Cardiología, Hospital Santos Reyes, Aranda de Duero, Burgos, Spain. Electronic address: dmratinr@saludcastillayleon.es.
authors.forename: Diego
authors.initials: D
authors.lastname: Martín Raymondi
mesh_terms: D001681:Biological Assay; D015415:Biomarkers / Q000378:metabolism; D059347:Cardio-Renal Syndrome / Q000175:diagnosis / Q000453:epidemiology; D002318:Cardiovascular Diseases / Q000175:diagnosis* / Q000453:epidemiology; D042241:Early Diagnosis; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology; D006333:Heart Failure / Q000175:diagnosis / Q000453:epidemiology; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000175:diagnosis / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012042:Registries; D012307:Risk Factors; D012680:Sensitivity and Specificity; D013030:Spain / Q000453:epidemiology; D020107:Troponin T / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D020107:Troponin T
keywords: Alto riesgo cardiovascular; High cardiovascular risk; High-sensitivity troponin T; Registro; Registry; Troponina T ultrasensible