title: Neonatal Soft Tissue Reconstruction Using a Bioengineered Skin Substitute.
abstract: Total parenteral nutrition (TPN) can be a lifesaving intervention for premature neonates and it is often delivered through peripheral access in this unique population. However, extravasation and tissue damage can result. Current literature lacks strong evidence regarding the treatment and reconstruction of such injuries in this age group. The authors present a patient with a 30-week gestational age premature newborn whom suffered an extravasation injury with peripherally administered TPN leading to full thickness skin and soft tissue necrosis of the dorsum of the right hand. This was serially debrided and ultimately repaired using Apligraf (Graftskin, Living Skin Equivalent, LSE; Organogenesis Inc, Canton, MA), which rapidly facilitated secondary healing.
authors.affiliation: Division of Plastic and Reconstructive Surgery, Department of Surgery, Virginia Commonwealth University School of Medicine, Richmond, VA.
authors.forename: Scott D
authors.initials: SD
authors.lastname: Hirsch
authors.forename: Jeremy M
authors.initials: JM
authors.lastname: Powers
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Rhodes
mesh_terms: D003094:Collagen; D062109:Dermatologic Surgical Procedures / Q000379:methods*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D010289:Parenteral Nutrition, Total / Q000009:adverse effects*; D017768:Skin, Artificial; D017695:Soft Tissue Injuries / Q000209:etiology / Q000601:surgery*; D014945:Wound Healing
chemical_list: C117898:Apligraf; D003094:Collagen