title: Superficial Acral Fibromyxoma of the Toe: Unusual Location of the Mixoid Variant.
abstract: Superficial acral fibromyxoma (SAFM) is a rare soft tissue tumor that frequently involves the periungual and subungual regions of acral surfaces. Macroscopically, it appears as a flesh-colored dome-shaped solitary mass; microscopically, it consists of a moderately cellular proliferation of spindle-shaped fibroblast-like cells embedded in a myxocollagenous stroma and arranged in a loose storiform and focally fascicular pattern. The tumor cells are immunoreactive for CD34, epithelial membrane antigen, CD99, and CD10. In this study, we describe a case of SAFM on the fourth toe with predominantly myxoid stroma. Our case, in contrast of those reported in the literature, showed an unusual location for the myxoid variant. SAFM is often not recognized; it may resemble some benign and malignant mesenchymal neoplasm. The gold standard treatment is surgery. The tumor was completely excised, and no recurrence was evident at 1-year follow-up. Awareness of this entity facilitates its diagnosis and management, avoiding unwarranted concerns and additional procedures for the patient.
authors.affiliation: *Department of Medicine, Surgery and Neurosciences, Dermatology Section, University of Siena, Italy; and †Department of Human Pathology and Oncology, Pathological Anatomy Section, University of Siena, Italy.
authors.forename: Arianna
authors.initials: A
authors.lastname: Lamberti
authors.forename: Clelia
authors.initials: C
authors.lastname: Miracco
authors.forename: Michele
authors.initials: M
authors.lastname: Fimiani
authors.forename: Pietro
authors.initials: P
authors.lastname: Rubegni
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D005350:Fibroma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D012983:Soft Tissue Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D014034:Toes; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor