title: Poly(ε-caprolactone) (PCL) hybrid sheets containing polymeric micelles: Effects of inner structures on the material properties of the sheets.
abstract: In the present paper, we clarify the effects that the composition of three types of sheets-the PCL sheet, the PCL-BC (PCL-block copolymer composite) sheet, and the PCL-PM (PCL-polymeric micelle composite) sheet-can have on (1) the sheets' inner structure, (2) the dispersity of hydrophilic compounds in the sheets, (3) the sheets' mechanical properties, and (4) the sheets' degradability. Our results show that (1) the PCL-PM sheet can disperse hydrophilic compounds uniformly, (2) the molecular state (free or micellar) of a co-existing compound (PEG-b-PCL block copolymers) affects the strength and the inner structures of the sheets, whereas the presence of a co-existing compound affects the flexibility of the sheets, and (3) according to our degradation experiment, hard-to-handle PCL having extremely low hydrolysis could serve as materials with a controllable surface morphology by the effective use of co-existing compounds. The results obtained in this paper show that the PCL-CM sheet, with its uniformly dispersed polymeric micelles providing hydrophilic spaces, could be an effective biomaterial platform for incorporating hydrophilic polymers.
authors.affiliation: Department of Organic and Polymer Materials Chemistry, Faculty of Engineering, Tokyo University of Agriculture and Technology, Japan.
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Anzai
authors.affiliation: Department of Organic and Polymer Materials Chemistry, Faculty of Engineering, Tokyo University of Agriculture and Technology, Japan.
authors.forename: Taku
authors.initials: T
authors.lastname: Takami
authors.affiliation: Department of Organic and Polymer Materials Chemistry, Faculty of Engineering, Tokyo University of Agriculture and Technology, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Uchida
authors.affiliation: Department of Organic and Polymer Materials Chemistry, Faculty of Engineering, Tokyo University of Agriculture and Technology, Japan. Electronic address: muray@cc.tuat.ac.jp.
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Murakami
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry; D003911:Dextrans / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry; D055119:Elastic Modulus; D016650:Fluorescein-5-isothiocyanate / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D007783:Lactones / Q000737:chemistry; D008823:Micelles; D008853:Microscopy; D011091:Polyesters / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D003911:Dextrans; D004337:Drug Carriers; D007783:Lactones; D008823:Micelles; D011091:Polyesters; C521904:poly(ethylene glycol)-block-poly(epsilon-caprolactone); C016240:polycaprolactone; D011092:Polyethylene Glycols; D016650:Fluorescein-5-isothiocyanate
keywords: Poly(ethylene glycol); Poly(ε-caprolactone); Polymeric micelle; Sheet