title: Development of a Modified Bouveault-Blanc Reduction for the Selective Synthesis of α,α-Dideuterio Alcohols.
abstract: A modified Bouveault-Blanc reduction has been developed for the synthesis of α,α-dideuterio alcohols from carboxylic acid esters. Sodium dispersions are used as the electron donor in this electron transfer reaction, and ethanol-d1is employed as the deuterium source. This reaction uses stable, cheap, and commercially available reagents, is operationally simple, and results in excellent deuterium incorporation across a broad range of aliphatic esters, which provides an attractive alternative to reactions mediated by expensive pyrophoric alkali metal deuterides.
authors.affiliation: College of Science, China Agricultural University , No. 2 Yuanmingyuan West Road, Beijing 100193, China.
authors.forename: Minhui
authors.initials: M
authors.lastname: Han
authors.affiliation: College of Science, China Agricultural University , No. 2 Yuanmingyuan West Road, Beijing 100193, China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Ma
authors.affiliation: College of Science, China Agricultural University , No. 2 Yuanmingyuan West Road, Beijing 100193, China.
authors.forename: Shangchu
authors.initials: S
authors.lastname: Yao
authors.affiliation: College of Science, China Agricultural University , No. 2 Yuanmingyuan West Road, Beijing 100193, China.
authors.forename: Yuxuan
authors.initials: Y
authors.lastname: Ding
authors.affiliation: College of Science, China Agricultural University , No. 2 Yuanmingyuan West Road, Beijing 100193, China.
authors.forename: Zihan
authors.initials: Z
authors.lastname: Yan
authors.affiliation: College of Science, China Agricultural University , No. 2 Yuanmingyuan West Road, Beijing 100193, China.
authors.forename: Adila
authors.initials: A
authors.lastname: Adijiang
authors.affiliation: College of Science, China Agricultural University , No. 2 Yuanmingyuan West Road, Beijing 100193, China.
authors.forename: Yufei
authors.initials: Y
authors.lastname: Wu
authors.affiliation: College of Science, China Agricultural University , No. 2 Yuanmingyuan West Road, Beijing 100193, China.
authors.forename: Hengzhao
authors.initials: H
authors.lastname: Li
authors.affiliation: College of Science, China Agricultural University , No. 2 Yuanmingyuan West Road, Beijing 100193, China.
authors.forename: Yuntong
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: College of Science, China Agricultural University , No. 2 Yuanmingyuan West Road, Beijing 100193, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Lei
authors.affiliation: College of Science, China Agricultural University , No. 2 Yuanmingyuan West Road, Beijing 100193, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Ling
authors.affiliation: College of Science, China Agricultural University , No. 2 Yuanmingyuan West Road, Beijing 100193, China.
authors.forename: Jie
authors.identifier: 0000-0002-1521-009X
authors.initials: J
authors.lastname: An