title: A multicenter survey of stage T1 glottic cancer treated with radiotherapy delivered in 2.25-Gy fractions in clinical practice: An initial 5-year analysis.
abstract: The purpose of this study was to evaluate the acute and late toxicity as well as local control (LC) in T1 glottic cancer (GC) patients treated with hypofractionated radiotherapy (RT) in clinical practice. The Tokai Study Group for Therapeutic Radiology and Oncology started RT treatment with a dose of 2.25 Gy for T1 GC in 2011. Ten institutions combined data from 104 patients with T1 squamous cell carcinoma between 2011 and 2015. In total, 104 patients with T1 GC were irradiated with a standard radiation dose of 63 Gy in 28 fractions.The median follow-up duration was 18 (3.7-49.5) months. Acute grade 3 adverse events were observed in 7 patients, with 4 patients (5%) having dermatitis and 3 patients (4%) having mucositis. Late adverse events above grade 3 were not observed. Two patients developed local recurrence. The rates of acute adverse events in the present study were comparable to those in previous studies that have used 2 Gy fractions of RT.
authors.affiliation: Department of Radiology Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Itoh
authors.affiliation: Department of Radiology Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Seiji
authors.initials: S
authors.lastname: Kubota
authors.affiliation: Department of Radiology Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Mariko
authors.initials: M
authors.lastname: Kawamura
authors.affiliation: Department of Radiology Mie University Graduate School of Medicine, Tsu, Japan.
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Nomoto
authors.affiliation: Department of Radiation Oncology Ichinomiya Municipal Hospital, Ichinomiya, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Murao
authors.affiliation: Department of Radiology Tosei General Hospital, Seto, Japan.
authors.forename: Kouji
authors.initials: K
authors.lastname: Yamakawa
authors.affiliation: Department of Radiology Toyohashi Municipal Hospital, Toyohashi, Japan.
authors.forename: Shunichi
authors.initials: S
authors.lastname: Ishihara
authors.affiliation: Department of Radiation Oncology Japanese Red Cross Nagoya Daiichi Hospital, Nagoya, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Hirasawa
authors.affiliation: Department of Radiation Oncology Gifu Prefectural Tajimi Hospital, Tajimi, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Asano
authors.affiliation: Department of Radiation Oncology Nakatsugawa City Hospital, Nakatsugawa, Japan.
authors.forename: Shigeo
authors.initials: S
authors.lastname: Yanagawa
authors.affiliation: Department of Radiology Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Naganawa
keywords: T1 glottic cancer; fraction size; hypofractionation; radiotherapy