title: Indirect Effects of Pneumococcal Conjugate Vaccines in National Immunization Programs for Children on Adult Pneumococcal Disease.
abstract: The pneumococcal conjugate vaccine (PCV) was developed to overcome the limitations of the pneumococcal polysaccharide vaccine, which produces poor immunogenicity in infants younger than 2 years. As many countries have included PCVs in national immunization programs for children, the incidence of invasive pneumococcal disease caused by vaccine type Streptococcus pneumoniae has declined markedly, not only among the vaccinated pediatric population, but also among unvaccinated adults. In this review, we present a concise overview of the indirect effects of mass pediatric PCV immunization on unvaccinated adults.
authors.affiliation: Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
authors.forename: Young Keun
authors.identifier: http://orcid.org/0000-0002-2120-6265
authors.initials: YK
authors.lastname: Kim
authors.affiliation: Division of Pulmonary, Allergy, and Critical Care, University of Alabama at Birmingham, Birmingham, AL, USA.
authors.forename: David
authors.identifier: http://orcid.org/0000-0001-5174-1931
authors.initials: D
authors.lastname: LaFon
authors.affiliation: Division of Pulmonary, Allergy, and Critical Care, University of Alabama at Birmingham, Birmingham, AL, USA. nahm@uab.edu.
authors.forename: Moon H
authors.initials: MH
authors.lastname: Nahm
keywords: Herd; Immunity; Mass vaccination; Pneumococcal infections; Pneumococcal vaccines