title: Cuboid Vesicles Formed by Frame-Guided Assembly on DNA Origami Scaffolds.
abstract: We describe the use of a frame-guided assembly (FGA) strategy to construct cuboid and dumbbell-shaped hetero-vesicles on DNA origami nanostructure scaffolds. These are achieved by varying the design of the DNA origami scaffolds that direct the distribution of the leading hydrophobic groups (LHG). By careful selection of LHGs, different types of amphiphiles (both polymer and small-molecule surfactants) were guided to form hetero-vesicles, demonstrating the versatility of the FGA strategy and its potential to construct asymmetric and dynamic hetero-vesicle assemblies with complex DNA nano-scaffolds.
authors.affiliation: Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, 100084, China.
authors.forename: Yuanchen
authors.initials: Y
authors.lastname: Dong
authors.affiliation: School of Molecular Sciences and Center of Molecular Design & Biomimetics at Biodesign Institute, Arizona State University, Tempe, AZ, 85287, USA.
authors.forename: Yuhe Renee
authors.initials: YR
authors.lastname: Yang
authors.affiliation: Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, 100084, China.
authors.forename: Yiyang
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, 100084, China.
authors.forename: Dianming
authors.initials: D
authors.lastname: Wang
authors.affiliation: School of Molecular Sciences and Center of Molecular Design & Biomimetics at Biodesign Institute, Arizona State University, Tempe, AZ, 85287, USA.
authors.forename: Xixi
authors.initials: X
authors.lastname: Wei
authors.affiliation: School of Molecular Sciences and Center of Molecular Design & Biomimetics at Biodesign Institute, Arizona State University, Tempe, AZ, 85287, USA.
authors.forename: Saswata
authors.initials: S
authors.lastname: Banerjee
authors.affiliation: School of Molecular Sciences and Center of Molecular Design & Biomimetics at Biodesign Institute, Arizona State University, Tempe, AZ, 85287, USA.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, 100084, China.
authors.forename: Zhongqiang
authors.initials: Z
authors.lastname: Yang
authors.affiliation: School of Molecular Sciences and Center of Molecular Design & Biomimetics at Biodesign Institute, Arizona State University, Tempe, AZ, 85287, USA.
authors.forename: Hao
authors.initials: H
authors.lastname: Yan
authors.affiliation: Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, 100084, China.
authors.forename: Dongsheng
authors.initials: D
authors.lastname: Liu
mesh_terms: D004247:DNA / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D053769:Nanocapsules / Q000737:chemistry* / Q000648:ultrastructure; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D036103:Nanotechnology / Q000379:methods*; D009690:Nucleic Acid Conformation; D013501:Surface-Active Agents / Q000737:chemistry*
chemical_list: D053769:Nanocapsules; D013501:Surface-Active Agents; D004247:DNA
keywords: DNA nanotechnology; amphiphiles; frame-guided assembly; self-assembly