title: Role of Azoles in Cancer Prevention and Treatment: Present and Future Perspectives.
abstract: Cancer has gradually become one of the leading causes of death worldwide. The incidence of cancer among the population has increased alarmingly over the last two decades, primarily due to an increasing population of immune-compromised patients and the continuing rise in anti-cancer drug resistance. Azole found privileged structure in medicinal chemistry and pharmaceutical industry and also found to be showing antioxidant; antimicrobial, anthelmintic, anticancer, antiviral, anti-parasitic, anti-inflammatory, anti-HIV, and antihypertensive activities.
  
  
  
  In this review, we highlight some areas of current interest in context to azoles and their derivatives as potential chemotherapeutic agents and inhibitors.
  
  
  
  A comprehensive literature search was performed for writing this review. An updated view on different derivatives of azoles and use in cancer management has been discussed.
  
  
  
  Here we have discussed the present scenario of azoles and their derivatives as potential chemotherapeutic agents and inhibitors. Along with, the future perspectives of azoles in cancer prevention and treatment are also discussed.
  
  
  
  The information provided in this review might be useful to researchers in designing of novel and potent multifunctional azole analogues for the treatment of cancer and other multifactorial diseases.
authors.affiliation: National Bureau of Agriculturally Important Microorganisms, Kushmaur, Mau Nath Bhanjan-275103, Uttar Pradesh, India.
authors.forename: Khurshid
authors.initials: K
authors.lastname: Ahmad
authors.affiliation: Department of Bioengineering, Integral University, Lucknow-226026, India.
authors.forename: Mohd Kalim A
authors.initials: MKA
authors.lastname: Khan
authors.affiliation: Department of Medical Biotechnology, Yeungnam University, Gyeongsan, Korea.
authors.forename: Mohammad Hassan
authors.initials: MH
authors.lastname: Baig
authors.affiliation: Bioinformatics Division, Institute of Cytology and Preventive Oncology (ICMR), Noida, U.P, India.
authors.forename: Mohd
authors.initials: M
authors.lastname: Imran
authors.affiliation: Department of Pharmaceutical Chemistry, M. M. College of Pharmacy, Maharishi Markandeshwar University, Mullana, Ambala-133207, Haryana, India.
authors.forename: Girish Kumar
authors.initials: GK
authors.lastname: Gupta
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D001393:Azoles / Q000737:chemistry / Q000494:pharmacology*; D005346:Fibroblast Growth Factors / Q000037:antagonists & inhibitors / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D047428:Protein Kinase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D051057:Proto-Oncogene Proteins c-akt / Q000037:antagonists & inhibitors / Q000378:metabolism; D017468:Receptors, Fibroblast Growth Factor / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D001393:Azoles; D047428:Protein Kinase Inhibitors; D017468:Receptors, Fibroblast Growth Factor; D005346:Fibroblast Growth Factors; D051057:Proto-Oncogene Proteins c-akt
keywords: Azoles; anti-HIV; cancer; derivatives.; prevention; treatment