title: Chemical constituents and antileukemic activity of Eugenia dysenterica.
abstract: The study about Eugenia dysenterica led to the isolation of 3-acetyl-urs-12-en-28-oic (1), 3-acetyl-olean-12-en-28-oic acid (2) and isoquercetin (3) from the stem barks, and of 3-O-β-glucopyranosyl-β-sitosterol (4), methyl 3-hydroxy-4-methoxybenzoate (5), methyl 4-hydroxyphenyl propionate (6), E-methyl-4-hydroxycinnamate (7), quercetin-3-O-(6ꞌꞌ-O-galloyl)-β-d-glucopyranoside (8) and quercetin-3-O-β-d-galactopyranoside (9) from the leaves. The structures 1-9 were set through the analysis of their NMR spectroscopic data. Compounds 2, 3 and 5-8 were reported for the first time in the Eugenia genus. Compound 8 reduced cell viability and presented IC50values 40.3 and 36.7 μM, for the CCRF-CEM and the Kasumi-1 cells, respectively.
authors.affiliation: a Programa de Pós-Graduação em Química , Universidade Federal de Mato Grosso , Cuiabá , Brazil.
authors.forename: Renan
authors.initials: R
authors.lastname: Vitek
authors.affiliation: a Programa de Pós-Graduação em Química , Universidade Federal de Mato Grosso , Cuiabá , Brazil.
authors.forename: Leice M R
authors.initials: LMR
authors.lastname: de Novais
authors.affiliation: b Departamento de Bioquímica , Universidade Federal de São Paulo , São Paulo , Brazil.
authors.forename: Heron F V
authors.initials: HFV
authors.lastname: Torquato
authors.affiliation: b Departamento de Bioquímica , Universidade Federal de São Paulo , São Paulo , Brazil.|c Centro Interdisciplinar de Investigação Bioquı́mica , Universidade de Mogi das Cruzes , Mogi das Cruzes , Brazil.
authors.forename: Edgar J
authors.initials: EJ
authors.lastname: Paredes-Gamero
authors.affiliation: d Departamento de Química , Universidade Federal Rural do Rio de Janeiro , Seropédica, Rio de Janeiro , Brazil.
authors.forename: Mário G
authors.initials: MG
authors.lastname: de Carvalho
authors.affiliation: a Programa de Pós-Graduação em Química , Universidade Federal de Mato Grosso , Cuiabá , Brazil.
authors.forename: Paulo T
authors.initials: PT
authors.lastname: de Sousa
authors.affiliation: a Programa de Pós-Graduação em Química , Universidade Federal de Mato Grosso , Cuiabá , Brazil.
authors.forename: Marcos J
authors.initials: MJ
authors.lastname: Jacinto
authors.affiliation: a Programa de Pós-Graduação em Química , Universidade Federal de Mato Grosso , Cuiabá , Brazil.
authors.forename: Virgínia C
authors.initials: VC
authors.lastname: da Silva
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D000068856:Eugenia / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology; D005697:Galactosides / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D007938:Leukemia / Q000188:drug therapy*; D009682:Magnetic Resonance Spectroscopy; D009828:Oleanolic Acid / Q000737:chemistry; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D011794:Quercetin / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; D005697:Galactosides; D010936:Plant Extracts; C508165:quercetin-3-O-beta-D-galactopyranoside; D009828:Oleanolic Acid; D011794:Quercetin
keywords: Eugenia dysenterica; cell cycle arrest; cell death; cell differentiation; galloyl flavonol; leukemia