title: Acute, 28days sub acute and genotoxic profiling of Quercetin-Magnesium complex in Swiss albino mice.
abstract: Quercetin-Magnesium complex is one of the youngest alkaline rare earth metal (Magnesium) complexes with flavonoids (Quercetin) in organo-metalic family. Earlier studies describe the details of the complex formation, characterization and antioxidant study of the complex but toxicity profile is still under darkness. The present study was taken up to investigate the oral acute toxicity, 28days repeated oral sub-acute toxicity study and genotoxicity study of Quercetin-Magnesium complex in Swiss albino mice. Quercetin-Magnesium complex showed mortality at a dose of 185mg/kg in the Swiss albino mice. In 28days repeated oral toxicity study, Quercetin-Magnesium complex was administered to both sex of Swiss albino mice at dose levels of 150, 130 and 100mg/kg body weight respectively. Where 150mg/kg dose shows increased levels of white blood cells and changes in total protein, serum creatinine and blood urea nitrogen. Histopathological study of Quercetin-Magnesium complex shows minor structural alteration in kidney at 150mg/kg dose. No observed toxic level found in 130mg/kg or below doses. No genotoxic effect found in any doses of the complex. Therefore 130mg/kg or below dose level could be better for further study.
authors.affiliation: Department of Pharmacology & Toxicology, GRD (PG) IMT, Pharmacy, Rajpur road, Dehradun 248001, Uttarakhand, India.
authors.forename: Nilanjan
authors.initials: N
authors.lastname: Ghosh
authors.affiliation: Department of Pharmacology, Krupanidhi College of Pharmacy, Bengaluru 560035, Karnataka, India. Electronic address: drrajendra1972@gmail.com.
authors.forename: Rajendra
authors.initials: R
authors.lastname: Sandur
authors.affiliation: Department of Pharmacology & Toxicology, GRD (PG) IMT, Pharmacy, Rajpur road, Dehradun 248001, Uttarakhand, India.
authors.forename: Deepanwita
authors.initials: D
authors.lastname: Ghosh
authors.affiliation: Department of Pharmacology, NSHM College of Pharmaceutical Technology, Kolkata 700053, West Bengal, India.
authors.forename: Souvik
authors.initials: S
authors.lastname: Roy
authors.affiliation: Department of Pharmacology, Acharya & BM Reddy College of Pharmacy, Bengaluru 560107, Karnataka, India. Electronic address: sureshjanadri@gmail.com.
authors.forename: Suresh
authors.initials: S
authors.lastname: Janadri
mesh_terms: D000818:Animals; D004249:DNA Damage / Q000187:drug effects* / Q000502:physiology; D005260:Female; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008274:Magnesium / Q000633:toxicity*; D008297:Male; D051379:Mice; D011794:Quercetin / Q000633:toxicity*; D011897:Random Allocation; D013997:Time Factors; D023382:Toxicity Tests, Acute / Q000379:methods*
chemical_list: D011794:Quercetin; D008274:Magnesium
keywords: Acute toxicity; Ames text; Bone marrow micro nucleus assay; Chromosomal aberration test; Quercetin-Magnesium complex; Repeated oral dose toxicity