title: Amine bridges grafted mesoporous silica, as a prolonged/controlled drug release system for the enhanced therapeutic effect of short life drugs.
abstract: Hybrid mesoporous silica SBA-15, with surface incorporated cross-linked long hydrophobic organic bridges was synthesized using stepwise synthesis. The synthesized materials were characterized by elemental analysis, infrared spectroscopy, nuclear magnetic resonance spectroscopy, nitrogen adsorption, X-rays diffraction, thermogravimetry and scanning and transmission electron microscopy. The functionalized material showed highly ordered mesoporous network with a surface area of 629.0m2g-1. The incorporation of long hydrophobic amine chains on silica surface resulted in high drug loading capacity (21% Mass/Mass) and prolonged release of ibuprofen up till 75.5h. The preliminary investigations suggests that the synthesized materials could be proposed as controlled release devices to prolong the therapeutic effect of short life drugs such as ibuprofen to increase its efficacy and to reduce frequent dosage.
authors.affiliation: Institute of Chemistry, University of Campinas, UNICAMP, P.O. Box 6154, 13084-971 Campinas, SP, Brazil; Interdisciplinary Research Centre in Biomedical Materials (IRCBM), COMSATS Institute of Information Technology, Lahore, Pakistan. Electronic address: foziaics@yahoo.com.
authors.forename: Fozia
authors.initials: F
authors.lastname: Rehman
authors.affiliation: Institute of Chemistry, University of Campinas, UNICAMP, P.O. Box 6154, 13084-971 Campinas, SP, Brazil.
authors.forename: Khalid
authors.initials: K
authors.lastname: Ahmed
authors.affiliation: Institute of Chemistry, University of Campinas, UNICAMP, P.O. Box 6154, 13084-971 Campinas, SP, Brazil.
authors.forename: Claudio
authors.initials: C
authors.lastname: Airoldi
authors.affiliation: UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.
authors.forename: Simon
authors.initials: S
authors.lastname: Gaisford
authors.affiliation: UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.
authors.forename: Asma
authors.initials: A
authors.lastname: Buanz
authors.affiliation: Interdisciplinary Research Centre in Biomedical Materials (IRCBM), COMSATS Institute of Information Technology, Lahore, Pakistan.
authors.forename: Abdur
authors.initials: A
authors.lastname: Rahim
authors.affiliation: Interdisciplinary Research Centre in Biomedical Materials (IRCBM), COMSATS Institute of Information Technology, Lahore, Pakistan.
authors.forename: Nawshad
authors.initials: N
authors.lastname: Muhammad
authors.affiliation: Institute of Chemistry, University of Campinas, UNICAMP, P.O. Box 6154, 13084-971 Campinas, SP, Brazil.
authors.forename: Pedro L O
authors.initials: PLO
authors.lastname: Volpe
mesh_terms: D000327:Adsorption; D000588:Amines / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D057927:Hydrophobic and Hydrophilic Interactions; D007052:Ibuprofen / Q000737:chemistry* / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D016062:Porosity; D053838:Scattering, Small Angle; D012822:Silicon Dioxide / Q000737:chemistry*; D013818:Thermogravimetry; D014961:X-Ray Diffraction
chemical_list: D000588:Amines; D004337:Drug Carriers; D012822:Silicon Dioxide; D007052:Ibuprofen
keywords: Ibuprofen and controlled drug release; Mesoporous silica; Surface modification