title: Diet-induced weight loss is sufficient to reduce senescent cell number in white adipose tissue of weight-cycled mice.
abstract: Previously, our laboratory reported that weight-cycled mice outlive their obese counterparts. To gain a better mechanistic understanding of these results, we evaluated cellular senescence in white adipose tissue (WAT) of lean, obese, and weight cycled mice. Our results show that at the end of a 28 day weight loss cycle cellular senescence is significantly reduced in multiple WAT depots compared to obese mice, which also corresponds to a reduction in circulating activin A (a marker of senescence). These findings suggest that a previously undescribed benefit to weight loss may be a reduction of cellular senescence in WAT.
authors.affiliation: Edison Biotechnology, Ohio University, Athens, OH, USA; Department of Specialty Medicine, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA; The Diabetes Institute, Ohio University, Athens, OH, USA.
authors.forename: Edward O
authors.initials: EO
authors.lastname: List
authors.affiliation: Edison Biotechnology, Ohio University , Athens, OH, USA.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Jensen
authors.affiliation: Edison Biotechnology, Ohio University , Athens, OH, USA.
authors.forename: Jesse
authors.initials: J
authors.lastname: Kowalski
authors.affiliation: Edison Biotechnology, Ohio University , Athens, OH, USA.
authors.forename: Mathew
authors.initials: M
authors.lastname: Buchman
authors.affiliation: Edison Biotechnology, Ohio University, Athens, OH, USA; The Diabetes Institute, Ohio University, Athens, OH, USA; Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA.
authors.forename: Darlene E
authors.initials: DE
authors.lastname: Berryman
authors.affiliation: Edison Biotechnology, Ohio University, Athens, OH, USA; The Diabetes Institute, Ohio University, Athens, OH, USA; Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA.
authors.forename: John J
authors.initials: JJ
authors.lastname: Kopchick
keywords: White adipose tissue; activin A; cellular senescence; obesity; weight cycling; weight loss; yo-yo diet