title: The Initial Months of Antiretroviral Therapy and Its Influence on AGEs, HMGB1, and sRAGE Levels in Asymptomatic HIV-Infected Individuals.
abstract: The development of the typical comorbidities of aging which currently affects people living with HIV/AIDS (PLWHA) can be partially ascribed to the persistent immune activation and chronic inflammation characterizing these individuals. The aim of this study was to analyze the effect exerted by combined antiretroviral therapy (cART) administration on plasma levels of HMGB1 (high mobility group box protein-1), AGEs (advanced glycation end products), their soluble receptor sRAGE, cytokines, C-reactive protein (CRP), and some metabolic markers in asymptomatic PLWHA. Analyses were performed longitudinally in 30 PLWHA, before and about 6-12 months after cART initiation. We observed that lower levels of AGEs in post-cART group were accompanied by an increase of CRP and triglyceride levels already in the early months of therapy. Because of the current ever-earlier recommendations to start cART and its prolonged use, these and other markers should be investigated in order to monitor and postpone the appearance of non-AIDS comorbidities in PLWHA.
authors.affiliation: Department of Tropical Diseases, Botucatu Medical School (FMB), Universidade Estadual Paulista (UNESP), Botucatu, SP, Brazil.
authors.forename: Karen Ingrid
authors.identifier: 0000-0002-3664-3978
authors.initials: KI
authors.lastname: Tasca
authors.affiliation: Department of Tropical Diseases, Botucatu Medical School (FMB), Universidade Estadual Paulista (UNESP), Botucatu, SP, Brazil.
authors.forename: Juliana Trindade
authors.initials: JT
authors.lastname: Caleffi
authors.affiliation: Department of Pathology, FMB/UNESP, Botucatu, SP, Brazil.
authors.forename: Camila Renata
authors.identifier: 0000-0001-8493-5329
authors.initials: CR
authors.lastname: Correa
authors.affiliation: Department of Tropical Diseases, Botucatu Medical School (FMB), Universidade Estadual Paulista (UNESP), Botucatu, SP, Brazil.
authors.forename: Mariana
authors.initials: M
authors.lastname: Gatto
authors.affiliation: Department of Tropical Diseases, Botucatu Medical School (FMB), Universidade Estadual Paulista (UNESP), Botucatu, SP, Brazil.
authors.forename: Caio Cavassan
authors.initials: CC
authors.lastname: de Camargo
authors.affiliation: Department of Tropical Diseases, Botucatu Medical School (FMB), Universidade Estadual Paulista (UNESP), Botucatu, SP, Brazil.
authors.forename: Monica Bannwart
authors.initials: MB
authors.lastname: Mendes
authors.affiliation: Hemocenter, FMB/UNESP, Botucatu, SP, Brazil.
authors.forename: Marjorie de Assis
authors.initials: MA
authors.lastname: Golim
authors.affiliation: Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy.
authors.forename: Mara
authors.initials: M
authors.lastname: Biasin
authors.affiliation: Department of Tropical Diseases, Botucatu Medical School (FMB), Universidade Estadual Paulista (UNESP), Botucatu, SP, Brazil.
authors.forename: Lenice do Rosário
authors.initials: LD
authors.lastname: de Souza
mesh_terms: D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology; D015897:Comorbidity; D005260:Female; D017127:Glycation End Products, Advanced / Q000097:blood*; D015658:HIV Infections / Q000097:blood* / Q000188:drug therapy*; D024243:HMGB1 Protein / Q000097:blood*; D006801:Humans; D007249:Inflammation; D016753:Interleukin-10 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D000067759:Receptor for Advanced Glycation End Products / Q000097:blood*; D014280:Triglycerides / Q000378:metabolism; D055815:Young Adult
chemical_list: D044966:Anti-Retroviral Agents; D015415:Biomarkers; D002097:C-Reactive Protein; D017127:Glycation End Products, Advanced; D024243:HMGB1 Protein; D016753:Interleukin-10; D015850:Interleukin-6; D016209:Interleukin-8; D000067759:Receptor for Advanced Glycation End Products; D014280:Triglycerides; C508606:CXCL8 protein, human; C585491:HMGB1 protein, human; C508609:IL10 protein, human; C508600:IL6 protein, human; C000593871:AGER protein, human