title: Update on the use of immunoglobulin in human disease: A review of evidence.
abstract: Human immunoglobulin preparations for intravenous or subcutaneous administration are the cornerstone of treatment in patients with primary immunodeficiency diseases affecting the humoral immune system. Intravenous preparations have a number of important uses in the treatment of other diseases in humans as well, some for which acceptable treatment alternatives do not exist. We provide an update of the evidence-based guideline on immunoglobulin therapy, last published in 2006. Given the potential risks and inherent scarcity of human immunoglobulin, careful consideration of its indications and administration is warranted.
authors.affiliation: Allergy Associates of the Palm Beaches, North Palm Beach, Fla. Electronic address: eperez@pballergy.com.
authors.forename: Elena E
authors.initials: EE
authors.lastname: Perez
authors.affiliation: Department of Pediatrics, Section of Immunology Allergy and Rheumatology, Center for Human Immunobiology, Texas Children's Hospital and Baylor College of Medicine, Houston, Tex.
authors.forename: Jordan S
authors.initials: JS
authors.lastname: Orange
authors.affiliation: Department of Pediatrics, Clinical Immunology Program, Children's Hospital Boston and Harvard Medical School, Boston, Mass.
authors.forename: Francisco
authors.initials: F
authors.lastname: Bonilla
authors.affiliation: Department of Pediatrics, Section of Immunology Allergy and Rheumatology, Center for Human Immunobiology, Texas Children's Hospital and Baylor College of Medicine, Houston, Tex.
authors.forename: Javier
authors.initials: J
authors.lastname: Chinen
authors.affiliation: Department of Pediatrics, Section of Immunology Allergy and Rheumatology, Center for Human Immunobiology, Texas Children's Hospital and Baylor College of Medicine, Houston, Tex.
authors.forename: Ivan K
authors.initials: IK
authors.lastname: Chinn
authors.affiliation: Department of Pediatrics, Allergy, Immunology and BMT Division, Benioff Children's Hospital and University of California, San Francisco, Calif.
authors.forename: Morna
authors.initials: M
authors.lastname: Dorsey
authors.affiliation: Department of Pediatrics, Pediatric Allergy and Immunology Unit, Children's Hospital and Ain Shams University, Cairo, Egypt.
authors.forename: Yehia
authors.initials: Y
authors.lastname: El-Gamal
authors.affiliation: Departments of Pathology and Laboratory Services and Pediatrics, University of Arkansas, Little Rock, Ark.
authors.forename: Terry O
authors.initials: TO
authors.lastname: Harville
authors.affiliation: Department of Pediatrics, Pediatric Allergy and Immunology Unit, Children's Hospital and Ain Shams University, Cairo, Egypt.
authors.forename: Elham
authors.initials: E
authors.lastname: Hossny
authors.affiliation: Department of Pediatrics, Allergy and Immunology, Montreal Children's Hospital and McGill University, Montreal, Quebec, Canada.
authors.forename: Bruce
authors.initials: B
authors.lastname: Mazer
authors.affiliation: Department of Medicine and Pediatrics, Division of Hematology and Oncology and Stem Cell Transplantation, Riley Hospital, Indiana University School of Medicine and the IU Melvin and Bren Simon Cancer Center, Indianapolis, Ind.
authors.forename: Robert
authors.initials: R
authors.lastname: Nelson
authors.affiliation: Department of Pediatrics, Wayne State University, Children's Hospital of Michigan, Detroit, Mich.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Secord
authors.affiliation: Nephrology & Transplant Immunology, Kidney Transplant Program, David Geffen School of Medicine at UCLA and Cedars-Sinai Medical Center, Los Angeles, Calif.
authors.forename: Stanley C
authors.initials: SC
authors.lastname: Jordan
authors.affiliation: Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, Calif.
authors.forename: E Richard
authors.initials: ER
authors.lastname: Stiehm
authors.affiliation: Transplant Immunotherapy Program, Comprehensive Transplant Center, Kidney Transplant Program, Cedars-Sinai Medical Center, Los Angeles, Calif.
authors.forename: Ashley A
authors.initials: AA
authors.lastname: Vo
authors.affiliation: Department of Pediatrics, Division of Allergy & Immunology, University of South Florida, Morsani College of Medicine, Johns Hopkins All Children's Hospital, St Petersburg, Fla.
authors.forename: Mark
authors.initials: M
authors.lastname: Ballow
mesh_terms: D000818:Animals; D019317:Evidence-Based Medicine; D006801:Humans; D056724:Immunity, Humoral; D007136:Immunoglobulins / Q000627:therapeutic use*; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D007153:Immunologic Deficiency Syndromes / Q000276:immunology / Q000628:therapy*; D056747:Immunomodulation; D007279:Injections, Subcutaneous; D017410:Practice Guidelines as Topic
chemical_list: D007136:Immunoglobulins; D016756:Immunoglobulins, Intravenous
keywords: IGIV; IVIG; Immune globulin; SCIG; adverse events; autoimmunity; immune modulating; immunoglobulin; immunomodulation; primary immunodeficiency; transfusion