title: Multiple Roles of WNT5A in Breast Cancer.
abstract: Breast cancer is one of the most common malignant tumors of women. Modern combinatorial therapeutic regimens can reduce patient tumor burdens to undetectable levels, yet in many cases these tumors will relapse. Understanding of breast cancer biology, developing more potent therapeutic approaches, and overcoming resistance are of great importance. WNT5A is a non-canonical signaling member of the WNT family. Its role in breast cancer still remains unclear. Most of the evidence shows that WNT5A is a suppressor in breast cancer and loss of its expression is associated with poor prognosis, while some evidence suggests the tumorigenicity of WNT5A. WNT signaling molecules are potent targets for treatment of cancer. Therefore, understanding the role of WNT5A in breast cancer may provide new ideas and methods for breast cancer treatment. We review the evidence concerning WNT5A and breast cancer involving the signaling pathways and the molecular-targeted therapy of WNT5A. Our results show that the role WNT5A plays depends on the availability of key receptors and intercellular interactions among different cell types.
authors.affiliation: Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, China (mainland).
authors.forename: Ruolan
authors.initials: R
authors.lastname: Zeng
authors.affiliation: Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, China (mainland).
authors.forename: Junhui
authors.initials: J
authors.lastname: Huang
authors.affiliation: Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, China (mainland).
authors.forename: Mei-Zuo
authors.initials: MZ
authors.lastname: Zhong
authors.affiliation: Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, China (mainland).
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Oncology, The First People's Hospital of Chenzhou, University of South China, Chenzhou, Hunan, China (mainland).
authors.forename: Guorong
authors.initials: G
authors.lastname: Yang
authors.affiliation: 32th Department, Hunan Tumor Hospital, The Affiliated Tumor Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China (mainland).
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Cardiothoracic Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China (mainland).
authors.forename: Yin
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, China (mainland).
authors.forename: Xiaoyi
authors.initials: X
authors.lastname: Yao
authors.affiliation: Department of Oncology, Xiangya Hospital, Central South University,, Changsha, Hunan, China (mainland).
authors.forename: Jing
authors.initials: J
authors.lastname: Shi
authors.affiliation: Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, China (mainland).
authors.forename: Zhifu
authors.initials: Z
authors.lastname: Wu
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000628:therapy; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D058990:Molecular Targeted Therapy; D015398:Signal Transduction; D051153:Wnt Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D051153:Wnt Proteins