title: Hints for control of infection in unique extrahepatic vertebral alveolar echinococcosis.
abstract: The prognosis of vertebral alveolar echinococcosis (AE) is poor. We report on the unique outcome of a patient with preexisting liver cirrhosis, in whom a diagnosis of vertebral AE was established on vertebral histopathology (D4 corporectomy in 2010 for paraplegia). Therapeutic drug monitoring of albendazole (ABZ) showed that a low dosage was appropriate. The patient recovered and ABZ withdrawal was decided in 2014, with no relapse 18 months later. In this patient, infection was purely or mainly localized in the dorsal spine, and this may have been favored by liver cirrhosis. A longer follow-up is, however, needed to confirm cure.
authors.affiliation: Service des maladies infectieuses et Tropicales, Centre Hospitalier Universitaire, Besançon, 25030, Besançon cedex, France. jffaucher@free.fr.
authors.forename: Jean-François
authors.identifier: http://orcid.org/0000-0002-1629-1194
authors.initials: JF
authors.lastname: Faucher
authors.affiliation: Service des maladies infectieuses et Tropicales, Centre Hospitalier Universitaire, Besançon, 25030, Besançon cedex, France.
authors.forename: Cécile
authors.initials: C
authors.lastname: Descotes-Genon
authors.affiliation: Service des maladies infectieuses et Tropicales, Centre Hospitalier Universitaire, Besançon, 25030, Besançon cedex, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Hoen
authors.affiliation: Service de neurochirurgie, Centre Hospitalier Universitaire, Besançon, France.
authors.forename: Joël
authors.initials: J
authors.lastname: Godard
authors.affiliation: Laboratoire d'anatomie et cytologie pathologique, Centre Hospitalier Universitaire, Besançon, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Félix
authors.affiliation: Service de radiologie ostéo-articulaire, Centre Hospitalier Universitaire, Besançon, France.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Aubry
authors.affiliation: Service de médecine nucléaire, Centre Hospitalier Universitaire, Besançon, France.
authors.forename: Oleg
authors.initials: O
authors.lastname: Blagosklonov
authors.affiliation: Laboratoire de parasitologie-mycologie, Centre Hospitalier Universitaire, Besançon, France.|WHO Collaborating Centre for Prevention and Treatment of Human Echinococcosis, Besançon, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Grenouillet
authors.affiliation: WHO Collaborating Centre for Prevention and Treatment of Human Echinococcosis, Besançon, France.|Laboratoire de pharmacologie clinique et toxicologie, Centre Hospitalier Universitaire, Besançon, France.
authors.forename: Marie-Pascale
authors.initials: MP
authors.lastname: Brientini
authors.affiliation: WHO Collaborating Centre for Prevention and Treatment of Human Echinococcosis, Besançon, France.|Service d'hépatologie, Centre Hospitalier Universitaire, Besançon, France.
authors.forename: Carine
authors.initials: C
authors.lastname: Richou
authors.affiliation: WHO Collaborating Centre for Prevention and Treatment of Human Echinococcosis, Besançon, France.
authors.forename: Solange
authors.initials: S
authors.lastname: Bresson-Hadni
authors.affiliation: Service des maladies infectieuses et Tropicales, Centre Hospitalier Universitaire, Besançon, 25030, Besançon cedex, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Chirouze
mesh_terms: D015766:Albendazole / Q000627:therapeutic use*; D000818:Animals; D000923:Anticestodal Agents / Q000627:therapeutic use*; D004443:Echinococcosis; D004444:Echinococcosis, Hepatic / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000469:parasitology; D048210:Echinococcus multilocularis / Q000502:physiology; D005602:France; D006801:Humans; D008103:Liver Cirrhosis / Q000209:etiology; D008297:Male; D008875:Middle Aged; D013122:Spinal Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000469:parasitology; D016896:Treatment Outcome
chemical_list: D000923:Anticestodal Agents; D015766:Albendazole
keywords: Alveolar echinococcosis; Cure; Therapeutic drug monitoring; Vertebral