title: Comparative evaluation of different volumes of 70% alcohol in celiac plexus block for upper abdominal malignsancies.
abstract: BACKGROUND
  Celiac plexus block (CPB) (is an effective way to reduce cancer-associated pain in upper abdominal malignancies.
  
  
  OBJECTIVE
  To evaluate the efficacy and safety of different volumes of 70% alcohol in CPB.
  
  
  METHODS
  Prospective, randomized, controlled clinical study.
  
  
  METHODS
  Thirty patients of carcinoma gall bladder were randomly divided into three groups (n= 10) to receive 20, 30, and 40 ml of 70% alcohol in CPB.
  
  
  METHODS
  All the continuous data were assessed analysis of variance followed bypost-hoctests (Tukey's Honestly Significant Difference test). Ordinal data were compared using Kruskal-Wallis H-test followed by Mann-Whitney U-test. Categorical comparisons were performed using Chi-square test.
  
  
  RESULTS
  A significant difference in visual analog scale (VAS) score of Group I, Group I and Group III was observed from week 6 onward until the end of the study. At all these time intervals, VAS scores in Group I was higher than both Groups II and III during this time interval. VAS scores in Group III were significantly lower as compared to Group II from week 10 onward until the end of the study. As compared to baseline, at all the follow-up intervals, mean morphine requirement was significantly lower in Group II and Group III. A quality of life (QOL) score of Group III were higher as compared to Group I. Between Group II and Group III, significant difference was observed at week 16 only when Group III had a higher score as compared to Group II.
  
  
  CONCLUSIONS
  VAS score, QOL, and reduction in morphine consumption were increased on increasing the volume of alcohol in CPB, 40 ml being most effective.
authors.affiliation: Department of Anesthesiology, King George Medical University, Lucknow, Uttar Pradesh, India.
authors.forename: Archana
authors.initials: A
authors.lastname: Dolly
authors.affiliation: Department of Anesthesiology, King George Medical University, Lucknow, Uttar Pradesh, India.
authors.forename: Sarita
authors.initials: S
authors.lastname: Singh
authors.affiliation: Department of Anesthesiology, King George Medical University, Lucknow, Uttar Pradesh, India.
authors.forename: Ravi
authors.initials: R
authors.lastname: Prakash
authors.affiliation: Department of Anesthesiology, King George Medical University, Lucknow, Uttar Pradesh, India.
authors.forename: Jaishri
authors.initials: J
authors.lastname: Bogra
authors.affiliation: Department of Anesthesiology, King George Medical University, Lucknow, Uttar Pradesh, India.
authors.forename: Anita
authors.initials: A
authors.lastname: Malik
authors.affiliation: Department of Anesthesiology, King George Medical University, Lucknow, Uttar Pradesh, India.
authors.forename: Vinita
authors.initials: V
authors.lastname: Singh
keywords: Alcohol; celiac plexus; lignocaine; malignancy; neurolysis; pain; transdiscal