title: Development and Cycloaddition Reactivity of a New Class of Pyridine-Based Mesoionic 1,3-Dipole.
abstract: We describe here the development and structural characterization of a new type of mesoionic 1,3-dipole, which can be generated in the one-step reaction of imines with pyridine- or quinoline-based acid chlorides. Coupling the formation of these dipoles with alkyne cycloaddition can open a general and modular route to synthesize indolizines from combinations of available and diversifiable building blocks.
authors.affiliation: Department of Chemistry, McGill University, 801 Sherbrooke St. W, Montreal, Quebec, H3A 0B8, Canada.
authors.forename: Huseyin
authors.initials: H
authors.lastname: Erguven
authors.affiliation: Department of Chemistry, McGill University, 801 Sherbrooke St. W, Montreal, Quebec, H3A 0B8, Canada.
authors.forename: David C
authors.initials: DC
authors.lastname: Leitch
authors.affiliation: Department of Chemistry, McGill University, 801 Sherbrooke St. W, Montreal, Quebec, H3A 0B8, Canada.
authors.forename: Evan N
authors.initials: EN
authors.lastname: Keyzer
authors.affiliation: Department of Chemistry, McGill University, 801 Sherbrooke St. W, Montreal, Quebec, H3A 0B8, Canada.
authors.forename: Bruce A
authors.identifier: 0000-0002-4915-9261
authors.initials: BA
authors.lastname: Arndtsen
keywords: 1,3 dipolar cycloaddition; heterocycles; indolizines; mesoionic dipoles; multicomponent reactions