title: Patient-specific 3D hemodynamics modelling of left coronary artery under hyperemic conditions.
abstract: The purpose of this study is to investigate the effect of various degrees of percentage stenosis on hemodynamic parameters during the hyperemic flow condition. 3D patient-specific coronary artery models were generated based on the CT scan data using MIMICS-18. Numerical simulation was performed for normal and stenosed coronary artery models of 70, 80 and 90% AS (area stenosis). Pressure, velocity, wall shear stress and fractional flow reserve (FFR) were measured and compared with the normal coronary artery model during the cardiac cycle. The results show that, as the percentage AS increase, the pressure drop increases as compared with the normal coronary artery model. Considerable elevation of velocity was observed as the percentage AS increases. The results also demonstrate a recirculation zone immediate after the stenosis which could lead to further progression of stenosis in the flow-disturbed area. Highest wall shear stress was observed for 90% AS as compared to other models that could result in the rupture of coronary artery. The FFR of 90% AS is found to be considerably low.
authors.affiliation: Department of Mechanical Engineering, University of Malaya, Kuala Lumpur, 50603, Malaysia. sarfaraz.kamangar@gmail.com.
authors.forename: Sarfaraz
authors.initials: S
authors.lastname: Kamangar
authors.affiliation: Department of Mechanical Engineering, University of Malaya, Kuala Lumpur, 50603, Malaysia. irfan_magami@rediffmail.com.
authors.forename: Irfan Anjum
authors.initials: IA
authors.lastname: Badruddin
authors.affiliation: Department of Mechanical and Industrial Engineering, Mekelle University, Mekelle, Ethiopia.
authors.forename: Kalimuthu
authors.initials: K
authors.lastname: Govindaraju
authors.affiliation: Department of Mechanical Engineering, University of Malaya, Kuala Lumpur, 50603, Malaysia.
authors.forename: N
authors.initials: N
authors.lastname: Nik-Ghazali
authors.affiliation: Department of Mechanical Engineering, University of Malaya, Kuala Lumpur, 50603, Malaysia.
authors.forename: A
authors.initials: A
authors.lastname: Badarudin
authors.affiliation: Institute of Cellular Medicine, Newcastle University, PL68DH, Newcastle upon Tyne, UK.
authors.forename: Girish N
authors.initials: GN
authors.lastname: Viswanathan
authors.affiliation: Dept. of Mechanical and Industrial Engineering, Sultan Qaboos University, 33, Al-khoud, Muscat, 123, Oman.
authors.forename: N J Salman
authors.initials: NJS
authors.lastname: Ahmed
authors.affiliation: Department of Mechanical Engineering, University of Malaya, Kuala Lumpur, 50603, Malaysia.
authors.forename: T M Yunus
authors.initials: TMY
authors.lastname: Khan
mesh_terms: D001783:Blood Flow Velocity; D001794:Blood Pressure; D003198:Computer Simulation; D003326:Coronary Circulation; D023921:Coronary Stenosis / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D003331:Coronary Vessels / Q000503:physiopathology*; D053805:Fractional Flow Reserve, Myocardial; D006439:Hemodynamics; D006801:Humans; D006940:Hyperemia / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D021621:Imaging, Three-Dimensional; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D066230:Patient-Specific Modeling; D033081:Shear Strength; D013314:Stress, Mechanical
keywords: Coronary artery; FFR; Non-Newtonian flow; Stenosis