title: [Acute tubule-interstitial nephritis].
abstract: Acute tubule-interstitial nephritis is a heterogeneous group of inflammatory diseases which affect renal parenchyma and tubules, mostly as a result of the immune-mediated injury. They are the important cause of acute kidney injury accounting for 5-15% of all its causes. In subsequent years, with the development of pharmacotherapy, the incidence of drug-induced nephrotoxicity has been increasing. The other causes of the acute tubule-interstitial nephritis are autoimmune and inflammatory diseases, infections, neoplasms and electrolyte abnormalities. The diagnostics are complex and treatment of the disease is not always easy. The following overview provides a summary of causes of acute tubule-interstitial nephritis, clinical picture of the disease, the diagnosis and treatment.
authors.affiliation: Katedra i Klinika Nefrologii, Dializoterapii i Chorób Wewnętrznych WUM, Warszawa, Polska, lniemczyk@wum.edu.pl.
authors.forename: Longin
authors.initials: L
authors.lastname: Niemczyk
authors.affiliation: Katedra i Klinika Nefrologii, Dializoterapii i Chorób Wewnętrznych WUM, Warszawa, Polska.
authors.forename: Mirosław
authors.initials: M
authors.lastname: Jędras
mesh_terms: D000208:Acute Disease / Q000628:therapy*; D058186:Acute Kidney Injury / Q000139:chemically induced / Q000209:etiology* / Q000628:therapy*; D006801:Humans; D009395:Nephritis, Interstitial / Q000139:chemically induced / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy*
keywords:  TINU syndrome ;  drug induced nephropathy; acute tubule-interstitial nephritis