title: Use of Cellular Decapping Activators by Positive-Strand RNA Viruses.
abstract: Positive-strand RNA viruses have evolved multiple strategies to not only circumvent the hostile decay machinery but to trick it into being a priceless collaborator supporting viral RNA translation and replication. In this review, we describe the versatile interaction of positive-strand RNA viruses and the 5'-3' mRNA decay machinery with a focus on the viral subversion of decapping activators. This highly conserved viral trickery is exemplified with the plant Brome mosaic virus, the animal Flock house virus and the human hepatitis C virus.
authors.affiliation: Molecular Virology Laboratory, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona 08003, Spain. Jennifer.Jungfleisch@upf.edu.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Jungfleisch
authors.affiliation: Molecular Virology Laboratory, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona 08003, Spain. Bernat.Blasco@upf.edu.
authors.forename: Bernat
authors.initials: B
authors.lastname: Blasco-Moreno
authors.affiliation: Molecular Virology Laboratory, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona 08003, Spain. juana.diez@upf.edu.
authors.forename: Juana
authors.initials: J
authors.lastname: Díez
mesh_terms: D000818:Animals; D017795:Bromovirus / Q000502:physiology*; D004722:Endoribonucleases / Q000378:metabolism*; D016174:Hepacivirus / Q000502:physiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D030381:Nodaviridae / Q000502:physiology*; D014176:Protein Biosynthesis; D020871:RNA Stability; D014779:Virus Replication
chemical_list: C030052:mRNA decapping enzymes; D004722:Endoribonucleases
keywords: mRNA decay; positive strand RNA viruses; virus–host interactions