title: Epigenetics and Common Ophthalmic Diseases.
abstract: The study of ocular diseases and epigenetic dysregulation is an emerging area of research. The knowledge from the epigenetic mechanisms of DNA methylation, histone modifications, chromatin remodeling, and non-coding RNAs regarding the pathogenesis of ocular diseases will be helpful for improved treatment modalities for our patients. In particular, we focus upon the how epigenetic regulatory mechanisms impact five common ocular diseases: age related macular degeneration, age-related cataract, pterygium, retinoblastoma, and uveal melanoma. Hence, the foundation of this research paves the way for future specific therapeutic targets to treat and prevent vision loss.
authors.affiliation: Department of Ophthalmology and Visual Science, Yale School of Medicine, New Haven, CT.
authors.forename: Wendy
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Ophthalmology and Visual Science, Yale School of Medicine, New Haven, CT.
authors.forename: Ji
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Ophthalmology and Visual Science, Yale School of Medicine, New Haven, CT.
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Galvin
mesh_terms: D002386:Cataract / Q000235:genetics; D019175:DNA Methylation / Q000235:genetics; D044127:Epigenesis, Genetic / Q000235:genetics*; D006801:Humans; D008545:Melanoma / Q000235:genetics; D011625:Pterygium / Q000235:genetics; D012175:Retinoblastoma / Q000235:genetics; D014604:Uveal Neoplasms / Q000235:genetics; D000098943:Uveal Melanoma
keywords: Age-related macular degeneration; cataract; epigenetics; pterygium; retinoblastoma; uveal melanoma