title: MetaboSignal: a network-based approach for topological analysis of metabotype regulation via metabolic and signaling pathways.
abstract: MetaboSignal is an R package that allows merging metabolic and signaling pathways reported in the Kyoto Encyclopaedia of Genes and Genomes (KEGG). It is a network-based approach designed to navigate through topological relationships between genes (signaling- or metabolic-genes) and metabolites, representing a powerful tool to investigate the genetic landscape of metabolic phenotypes.
  
  
  
  MetaboSignal is available from Bioconductor: https://bioconductor.org/packages/MetaboSignal/.
  
  
  
  m.dumas@imperial.ac.uk .
  
  
  
  Supplementary data are available at Bioinformatics online.
authors.affiliation: Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, SW7 2AZ London, UK.
authors.forename: Andrea
authors.initials: A
authors.lastname: Rodriguez-Martinez
authors.affiliation: Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, SW7 2AZ London, UK.
authors.forename: Rafael
authors.initials: R
authors.lastname: Ayala
authors.affiliation: Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, SW7 2AZ London, UK.
authors.forename: Joram M
authors.initials: JM
authors.lastname: Posma
authors.affiliation: Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, SW7 2AZ London, UK.
authors.forename: Ana L
authors.initials: AL
authors.lastname: Neves
authors.affiliation: Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, SW7 2AZ London, UK.|Sorbonne Universities, University Pierre & Marie Curie, University Paris Descartes, Sorbonne Paris Cité, INSERMUMR_S 1138, Cordeliers Research Centre, 75006 Paris, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Gauguier
authors.affiliation: Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, SW7 2AZ London, UK.
authors.forename: Jeremy K
authors.initials: JK
authors.lastname: Nicholson
authors.affiliation: Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, SW7 2AZ London, UK.
authors.forename: Marc-Emmanuel
authors.initials: ME
authors.lastname: Dumas
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D019295:Computational Biology / Q000379:methods*; D053858:Metabolic Networks and Pathways; D040641:Quantitative Trait Loci; D051381:Rats; D015398:Signal Transduction; D012984:Software