title: Hemocompatibility evaluation of poly(1,8-octanediol citrate) blend polyethersulfone membranes.
abstract: In this study, poly (1,8-octanediol citrate) (POC) was used to modify polyethersulfone (PES)-based membrane to enhance its hemocompatibility. Different compositions of POC (0-3%) were added into the polyethersulfone (PES) dope solutions and polyvinylpyrrolidone (PVP) was used as pore forming agent. The hemocompatible POC modified PES membranes were fabricated through phase-inversion technique. The prepared membranes were characterized using attenuated total reflectance-Fourier transform infrared (ATR-FTIR), thermogravimetric analysis (TGA), scanning electron microscopy (SEM), Atomic-force microscopy (AFM), contact angle, Zeta-potential, membrane porosity and pore size and pure water flux (PWF) and BSA rejection. The hemocompatibility of the modified PES membranes was evaluated by human serum fibrinogen (FBG) protein adsorption, platelet adhesion, activated partial thromboplastin time (APTT) and prothrombin time (PT), and thrombin-antithrombin III (TAT), complement (C3a and C5a) activation and Ca2+absorption on membrane. Results showed that by increasing POC concentration, FBG adsorption was reduced, less platelets adhesion, prolonged APTT and PT, lower TAT, C5a and C3a activation and absorb more Ca2+ion. These results indicated that modification of PES with POC has rendered improved hemocompatibility properties for potential application in the field of blood purification, especially in hemodialysis. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 1510-1520, 2017.
authors.affiliation: Advanced Membrane Technology Research Center (AMTEC), Universiti Teknologi Malaysia, Skudai, Johor, 81310, Malaysia.
authors.forename: Muhamad Zulhilmi
authors.initials: MZ
authors.lastname: Zailani
authors.affiliation: Advanced Membrane Technology Research Center (AMTEC), Universiti Teknologi Malaysia, Skudai, Johor, 81310, Malaysia.
authors.forename: Ahmad Fauzi
authors.initials: AF
authors.lastname: Ismail
authors.affiliation: Faculty of Medicine, Institute of Medical Molecular and Biotechnology (IMMB), Universiti Teknologi MARA (UiTM), Sungai Buloh, Selangor, 47000, Malaysia.
authors.forename: Siti Hamimah
authors.initials: SH
authors.lastname: Sheikh Abdul Kadir
authors.affiliation: Advanced Membrane Technology Research Center (AMTEC), Universiti Teknologi Malaysia, Skudai, Johor, 81310, Malaysia.
authors.forename: Mohd Hafiz Dzarfan
authors.initials: MH
authors.lastname: Othman
authors.affiliation: Advanced Membrane Technology Research Center (AMTEC), Universiti Teknologi Malaysia, Skudai, Johor, 81310, Malaysia.
authors.forename: Pei Sean
authors.initials: PS
authors.lastname: Goh
authors.affiliation: Advanced Membrane Technology Research Center (AMTEC), Universiti Teknologi Malaysia, Skudai, Johor, 81310, Malaysia.
authors.forename: Hasrinah
authors.initials: H
authors.lastname: Hasbullah
authors.affiliation: Advanced Membrane Technology Research Center (AMTEC), Universiti Teknologi Malaysia, Skudai, Johor, 81310, Malaysia.
authors.forename: Mohd Sohaimi
authors.initials: MS
authors.lastname: Abdullah
authors.affiliation: Advanced Membrane Technology Research Center (AMTEC), Universiti Teknologi Malaysia, Skudai, Johor, 81310, Malaysia.
authors.forename: Be Cheer
authors.initials: BC
authors.lastname: Ng
authors.affiliation: Faculty of Medicine, Institute of Medical Molecular and Biotechnology (IMMB), Universiti Teknologi MARA (UiTM), Sungai Buloh, Selangor, 47000, Malaysia.
authors.forename: Fatmawati
authors.initials: F
authors.lastname: Kamal
mesh_terms: D000328:Adult; D001792:Blood Platelets / Q000378:metabolism*; D001798:Blood Proteins / Q000737:chemistry / Q000378:metabolism; D002951:Citrates / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D008297:Male; D008422:Materials Testing; D008567:Membranes, Artificial; D010973:Platelet Adhesiveness / Q000187:drug effects*; D011108:Polymers / Q000737:chemistry / Q000494:pharmacology; D006435:Renal Dialysis / Q000295:instrumentation / Q000379:methods; D013450:Sulfones / Q000737:chemistry / Q000494:pharmacology
chemical_list: D001798:Blood Proteins; D002951:Citrates; D008567:Membranes, Artificial; D011108:Polymers; D013450:Sulfones; C513817:poly(1,8-octanediol citrate); C022840:polyether sulfone
keywords: hemocompatible; hemodialysis membrane; poly(1,8-octanediol citrate) (POC); poly(diol citrates); polyethersulfone (PES)