title: Intensive Care Unit Admission for Patients in the INTERACT2 ICH Blood Pressure Treatment Trial: Characteristics, Predictors, and Outcomes.
abstract: BACKGROUND
  Wide variation exists in criteria for accessing intensive care unit (ICU) facilities for managing patients with critical illnesses such as acute intracerebral hemorrhage (ICH). We aimed to determine the predictors of admission, length of stay, and outcome for ICU among participants of the main Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2).
  
  
  METHODS
  INTERACT2 was an international, open, blinded endpoint, randomized controlled trial of 2839 ICH patients (<6 h) and elevated systolic blood pressure (SBP) allocated to receive intensive (target SBP <140 mmHg within 1 h) or guideline-recommended (target SBP <180 mmHg) BP-lowering treatment. The primary outcome was death or major disability, defined by modified Rankin scale scores 3-6 at 90 days. Logistic regression and propensity score analyses were used to determine independent associations.
  
  
  RESULTS
  Predictors of ICU admission included younger age, recruitment in China, prior ischemic/undetermined stroke, high SBP, severe stroke [National Institute of Health stroke scale (NIHSS) score ≥15], large ICH volume (≥15 mL), intraventricular hemorrhage (IVH) extension, early neurological deterioration, intubation and surgery. Determinants of prolonged ICU stay (≥5 days) were prior antihypertensive use, NIHSS ≥15, large ICH volume, lobar ICH location, IVH, early neurological deterioration, intubation and surgery. ICU admission was associated with higher-risk major disability at 90-day assessment compared to those without ICU admission.
  
  
  CONCLUSIONS
  This study presents prognostic variables for ICU management and outcome of ICH patients included in a large international cohort. These data may assist in the selection and counseling of patients and families concerning ICU admission.
authors.affiliation: Neurointensive Care Unit, Martin-Luther-University Halle-Wittenberg, Halle, Germany.
authors.forename: Katja E
authors.initials: KE
authors.lastname: Wartenberg
authors.affiliation: Neurological and Mental Health Division, The George Institute for Global Health, University of Sydney, and Neurology Department, Royal Prince Alfred Hospital, PO Box M201, Missenden Road, Sydney, NSW, 2050, Australia.
authors.forename: Xia
authors.initials: X
authors.lastname: Wang
authors.affiliation: Neurological and Mental Health Division, The George Institute for Global Health, University of Sydney, and Neurology Department, Royal Prince Alfred Hospital, PO Box M201, Missenden Road, Sydney, NSW, 2050, Australia.|Neurology Service, Department of Medicine, Clínica Alemana de Santiago, Universidad del Desarrollo, Santiago, Chile.
authors.forename: Paula
authors.initials: P
authors.lastname: Muñoz-Venturelli
authors.affiliation: Department of Neurology, Mayo Clinic, Rochester, MN, USA.
authors.forename: Alejandro A
authors.initials: AA
authors.lastname: Rabinstein
authors.affiliation: Neurology Service, Department of Medicine, Clínica Alemana de Santiago, Universidad del Desarrollo, Santiago, Chile.|Universidad de Chile, Santiago, Chile.
authors.forename: Pablo M
authors.initials: PM
authors.lastname: Lavados
authors.affiliation: Neurological and Mental Health Division, The George Institute for Global Health, University of Sydney, and Neurology Department, Royal Prince Alfred Hospital, PO Box M201, Missenden Road, Sydney, NSW, 2050, Australia. canderson@georgeinstitute.org.au.|The George Institute, Peking University Health Sciences Center, Beijing, China. canderson@georgeinstitute.org.au.
authors.forename: Craig S
authors.initials: CS
authors.lastname: Anderson
authors.affiliation: Department of Cardiovascular Sciences and NIHR Biomedical Research Unit for Cardiovascular Diseases, University of Leicester, Leicester, UK.
authors.forename: Thompson
authors.initials: T
authors.lastname: Robinson
mesh_terms: D000368:Aged; D002543:Cerebral Hemorrhage / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D006973:Hypertension / Q000628:therapy*; D007362:Intensive Care Units / Q000706:statistics & numerical data*; D007902:Length of Stay / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care / Q000706:statistics & numerical data*; D010343:Patient Admission / Q000706:statistics & numerical data*; D012720:Severity of Illness Index; D016037:Single-Blind Method
keywords: Duration of stay; Intensive care unit; Intracranial hemorrhage; Mortality; Outcome predictors