title: Effects of Alpha-Lipoic Acid Supplementation on Plasma Adiponectin Levels and Some Metabolic Risk Factors in Patients with Schizophrenia.
abstract: Adiponectin is an adipocyte-derived plasma protein with insulin-sensitizing and anti-inflammatory properties and is suggested to be a biomarker of metabolic disturbances. The aim of this study was to investigate the effects of alpha-lipoic acid (ALA) on plasma adiponectin and some metabolic risk factors in patients with schizophrenia. The plasma adipokine levels (adiponectin and leptin), routine biochemical and anthropometric parameters, markers of oxidative stress, and the serum phospholipid fatty acid profile in eighteen schizophrenic patients at baseline, in the middle, and at the end of a 3-month long supplementation period with ALA (500 mg daily) were determined. A significant increase in the plasma adiponectin concentrations, as well as a decrease in fasting glucose and aspartate aminotransferase activity (AST), was found. Baseline AST activity was independently correlated with the adiponectin concentrations. Our data show that ALA can improve plasma adiponectin levels and may play a potential role in the treatment of metabolic risk factor in patients with schizophrenia. Future randomized controlled trials are needed to confirm these preliminary investigations.
authors.affiliation: 1 Department of Bromatology, Faculty of Pharmacy, University of Belgrade , Belgrade, Serbia .
authors.forename: Bojana
authors.initials: B
authors.lastname: Vidović
authors.affiliation: 2 Faculty of Medicine, University of Belgrade , Belgrade, Serbia .|3 Clinic for Psychiatry, Clinical Centre of Serbia , Belgrade, Serbia .
authors.forename: Srđan
authors.initials: S
authors.lastname: Milovanović
authors.affiliation: 4 Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade , Belgrade, Serbia .
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Stefanović
authors.affiliation: 4 Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade , Belgrade, Serbia .
authors.forename: Jelena
authors.initials: J
authors.lastname: Kotur-Stevuljević
authors.affiliation: 5 Centre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, University of Belgrade , Belgrade, Serbia .
authors.forename: Marija
authors.initials: M
authors.lastname: Takić
authors.affiliation: 5 Centre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, University of Belgrade , Belgrade, Serbia .
authors.forename: Jasmina
authors.initials: J
authors.lastname: Debeljak-Martačić
authors.affiliation: 3 Clinic for Psychiatry, Clinical Centre of Serbia , Belgrade, Serbia .
authors.forename: Maja
authors.initials: M
authors.lastname: Pantović
authors.affiliation: 1 Department of Bromatology, Faculty of Pharmacy, University of Belgrade , Belgrade, Serbia .
authors.forename: Brižita
authors.initials: B
authors.lastname: Đorđević
mesh_terms: D054392:Adipokines / Q000097:blood; D052242:Adiponectin / Q000097:blood*; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D019587:Dietary Supplements / Q000032:analysis; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D008063:Thioctic Acid / Q000008:administration & dosage*; D055815:Young Adult
chemical_list: D054392:Adipokines; D052242:Adiponectin; D001786:Blood Glucose; D007328:Insulin; D020738:Leptin; D008063:Thioctic Acid
keywords: adipocytokines; antipsychotic drugs; metabolic disturbances; nutraceuticals