title: Prognostic Differences: Epstein-Barr Virus-Associated Primary Leiomyosarcoma of the Spine Versus Spinal Leiomyosarcoma Metastases.
abstract: OBJECTIVE
  The authors studied 6 cases of osseous leiomyosarcoma of the spine. Two of these cases were of immunocompromised human immunodeficiency virus (HIV)-positive patients with Epstein-Barr virus (EBV)-associated primary vertebral leiomyosarcomas. The remaining 4 cases were of patients with leiomyosarcoma metastases to the spine.
  
  
  METHODS
  Each patient underwent surgical resection of their vertebral mass; however, the patients with the EBV-associated tumors had the best postoperative prognosis.
  
  
  RESULTS
  The HIV-positive patients have had no further local recurrence, while the other 4 patients had rapid local recurrences requiring multiple surgical interventions. Furthermore, the patients living with HIV have lived longer with fewer leiomyosarcoma-related health complications.
  
  
  CONCLUSIONS
  These findings suggest that EBV-associated vertebral leiomyosarcoma is of a less aggressive variety than metastatic leiomyosarcoma of the spine.
authors.affiliation: Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA; Department of Neurological Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
authors.forename: Nitin
authors.initials: N
authors.lastname: Agarwal
authors.affiliation: Department of Radiology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.
authors.forename: David R
authors.initials: DR
authors.lastname: Hansberry
authors.affiliation: Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA.
authors.forename: Ami
authors.initials: A
authors.lastname: Kavi
authors.affiliation: Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
authors.forename: Prateek
authors.initials: P
authors.lastname: Agarwal
authors.affiliation: Department of Pathology, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
authors.forename: Ada
authors.initials: A
authors.lastname: Baisre
authors.affiliation: Department of Neurological Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, USA. Electronic address: goldstir@njms.rutgers.edu.
authors.forename: Ira M
authors.initials: IM
authors.lastname: Goldstein
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002648:Child; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D000077143:Docetaxel; D020031:Epstein-Barr Virus Infections / Q000150:complications / Q000276:immunology; D005260:Female; D004854:Herpesvirus 4, Human; D006801:Humans; D016867:Immunocompromised Host; D007890:Leiomyosarcoma / Q000473:pathology / Q000556:secondary / Q000628:therapy* / Q000821:virology; D008297:Male; D008479:Mediastinal Neoplasms / Q000150:complications / Q000473:pathology / Q000628:therapy* / Q000821:virology; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011379:Prognosis; D012186:Retroperitoneal Neoplasms / Q000150:complications / Q000473:pathology / Q000628:therapy* / Q000821:virology; D013125:Spinal Neoplasms / Q000473:pathology / Q000556:secondary / Q000628:therapy* / Q000821:virology; D043823:Taxoids / Q000008:administration & dosage; D000093542:Gemcitabine
chemical_list: D043823:Taxoids; D003841:Deoxycytidine; D000077143:Docetaxel; D000093542:Gemcitabine
keywords: AIDS; Metastatic leiomyosarcoma; Spinal leiomyosarcoma; Spinal metastasis