title: Brain Vascular Imaging Techniques.
abstract: Recent major improvements in a number of imaging techniques now allow for the study of the brain in ways that could not be considered previously. Researchers today have well-developed tools to specifically examine the dynamic nature of the blood vessels in the brain during development and adulthood; as well as to observe the vascular responses in disease situations in vivo. This review offers a concise summary and brief historical reference of different imaging techniques and how these tools can be applied to study the brain vasculature and the blood-brain barrier integrity in both healthy and disease states. Moreover, it offers an overview on available transgenic animal models to study vascular biology and a description of useful online brain atlases.
authors.affiliation: Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, 75185 Uppsala, Sweden. barbara.lavina-siemsen@igp.uu.se.
authors.forename: Bàrbara
authors.initials: B
authors.lastname: Laviña
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000000981:diagnostic imaging*; D001921:Brain / Q000098:blood supply* / Q000000981:diagnostic imaging*; D006801:Humans; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging; D059906:Neuroimaging / Q000379:methods*; D049268:Positron-Emission Tomography; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed
keywords: animal models; brain atlas; brain vascular disorders; computed tomography (CT); imaging; magnetic resonance angiography (MRA); magnetic resonance angiography (MRI); molecular imaging; photoacoustic imaging (PAI); positron emission tomography (PET); vascular biology