title: Acquired hemophagocytic syndrome in a patient with synovial sarcoma: a case report.
abstract: Hemophagocytic lymphohistiocytosis (HLH) is a syndrome characterized by severe hyperinflammation due to an overwhelming ineffective immune response to different triggers. Most important symptoms are fever, hepatosplenomegaly and cytopenias. Biochemical signs include elevated ferritin, hypertriglyceridemia and low fibrinogen. Hemophagocytosis in the bone marrow is a hallmark of this syndrome. Based on the pathogenetic mechanism, it can be classified into primary (inherited) or secondary (acquired) HLH. We report, to our knowledge, the first case of acquired hemophagocytic syndrome that arose in a 20-year-old man affected by synovial sarcoma as a complication during chemotherapy.
authors.affiliation: Medical Oncology, Azienda Ospedaliera Universitaria Integrata (A.O.U.I.), University of Verona, P.le L.A Scuro 10, 37134 Verona, Italy; Medical Oncology, Azienda Ospedaliera Universitaria Integrata (A.O.U.I.), University of Verona, P.le L.A Scuro 10, 37134 Verona, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Ciccarese
authors.affiliation: Medical Oncology, Azienda Ospedaliera Universitaria Integrata (A.O.U.I.), University of Verona, P.le L.A Scuro 10, 37134 Verona, Italy; Medical Oncology, Azienda Ospedaliera Universitaria Integrata (A.O.U.I.), University of Verona, P.le L.A Scuro 10, 37134 Verona, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Ferrara
authors.affiliation: Medical Oncology, Azienda Ospedaliera Universitaria Integrata (A.O.U.I.), University of Verona, P.le L.A Scuro 10, 37134 Verona, Italy; Medical Oncology, Azienda Ospedaliera Universitaria Integrata (A.O.U.I.), University of Verona, P.le L.A Scuro 10, 37134 Verona, Italy.
authors.forename: Emanuela
authors.initials: E
authors.lastname: Fantinel
authors.affiliation: Medical Oncology, Azienda Ospedaliera Universitaria Integrata (A.O.U.I.), University of Verona, P.le L.A Scuro 10, 37134 Verona, Italy; Medical Oncology, Azienda Ospedaliera Universitaria Integrata (A.O.U.I.), University of Verona, P.le L.A Scuro 10, 37134 Verona, Italy.
authors.forename: Camilla
authors.initials: C
authors.lastname: Zecchetto
authors.affiliation: Medical Oncology, Azienda Ospedaliera Universitaria Integrata (A.O.U.I.), University of Verona, P.le L.A Scuro 10, 37134 Verona, Italy; Medical Oncology, Azienda Ospedaliera Universitaria Integrata (A.O.U.I.), University of Verona, P.le L.A Scuro 10, 37134 Verona, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Simionato
authors.affiliation: Medical Oncology, Azienda Ospedaliera Universitaria Integrata (A.O.U.I.), University of Verona, P.le L.A Scuro 10, 37134 Verona, Italy; Medical Oncology, Azienda Ospedaliera Universitaria Integrata (A.O.U.I.), University of Verona, P.le L.A Scuro 10, 37134 Verona, Italy.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Grego
authors.affiliation: Medical Oncology, Azienda Ospedaliera Universitaria Integrata (A.O.U.I.), University of Verona, P.le L.A Scuro 10, 37134 Verona, Italy; Medical Oncology, Azienda Ospedaliera Universitaria Integrata (A.O.U.I.), University of Verona, P.le L.A Scuro 10, 37134 Verona, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Ortolani
authors.affiliation: Medical Oncology, Azienda Ospedaliera Universitaria Integrata (A.O.U.I.), University of Verona, P.le L.A Scuro 10, 37134 Verona, Italy; Medical Oncology, Azienda Ospedaliera Universitaria Integrata (A.O.U.I.), University of Verona, P.le L.A Scuro 10, 37134 Verona, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Caccese
authors.affiliation: Medical Oncology, Azienda Ospedaliera Universitaria Integrata (A.O.U.I.), University of Verona, P.le L.A Scuro 10, 37134 Verona, Italy; Medical Oncology, Azienda Ospedaliera Universitaria Integrata (A.O.U.I.), University of Verona, P.le L.A Scuro 10, 37134 Verona, Italy.
authors.forename: Davide
authors.initials: D
authors.lastname: Bimbatti
authors.affiliation: Medical Oncology, Azienda Ospedaliera Universitaria Integrata (A.O.U.I.), University of Verona, P.le L.A Scuro 10, 37134 Verona, Italy; Medical Oncology, Azienda Ospedaliera Universitaria Integrata (A.O.U.I.), University of Verona, P.le L.A Scuro 10, 37134 Verona, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Cingarlini
authors.affiliation: Department of Pathology & Diagnostic, Azienda Ospedaliera Universitaria Integrata (A.O.U.I.), University of Verona, Verona, Italy; Department of Pathology & Diagnostic, Azienda Ospedaliera Universitaria Integrata (A.O.U.I.), University of Verona, Verona, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Brunelli
authors.affiliation: Department of Medicine, Section of Hematology & Bone Marrow Transplant Unit, Azienda Ospedaliera Universitaria Integrata (A.O.U.I.), University of Verona, Verona, Italy; Department of Medicine, Section of Hematology & Bone Marrow Transplant Unit, Azienda Ospedaliera Universitaria Integrata (A.O.U.I.), University of Verona, Verona, Italy.
authors.forename: Angelo
authors.initials: A
authors.lastname: Andreini
authors.affiliation: Medical Oncology, Azienda Ospedaliera Universitaria Integrata (A.O.U.I.), University of Verona, P.le L.A Scuro 10, 37134 Verona, Italy; Medical Oncology, Azienda Ospedaliera Universitaria Integrata (A.O.U.I.), University of Verona, P.le L.A Scuro 10, 37134 Verona, Italy.
authors.forename: Giampaolo
authors.initials: G
authors.lastname: Tortora
authors.affiliation: Medical Oncology, Azienda Ospedaliera Universitaria Integrata (A.O.U.I.), University of Verona, P.le L.A Scuro 10, 37134 Verona, Italy; Medical Oncology, Azienda Ospedaliera Universitaria Integrata (A.O.U.I.), University of Verona, P.le L.A Scuro 10, 37134 Verona, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Massari
keywords: chemotherapy; hemophagocytic lymphohistiocytosis syndrome; synovial sarcoma