title: Functionalized Nano-MoS2with Peroxidase Catalytic and Near-Infrared Photothermal Activities for Safe and Synergetic Wound Antibacterial Applications.
abstract: We have developed a biocompatible antibacterial system based on polyethylene glycol functionalized molybdenum disulfide nanoflowers (PEG-MoS2NFs). The PEG-MoS2NFs have high near-infrared (NIR) absorption and peroxidase-like activity, which can efficiently catalyze decomposition of low concentration of H2O2to generate hydroxyl radicals (·OH). The conversion of H2O2into ·OH can avoid the toxicity of high concentration of H2O2and the ·OH has higher antibacterial activity, making resistant bacteria more vulnerable and wounds more easily cured. The PEG-MoS2NFs combine the catalysis with NIR photothermal effect, providing a rapid and effective killing outcome in vitro for Gram-negative ampicillin resistant Escherichia coli (AmprE. coli) and Gram-positive endospore-forming Bacillus subtilis (B. subtilis) as compared to catalytic treatment or photothermal therapy (PTT) alone. Wound healing results indicate that the synergy antibacterial system could be conveniently used for wound disinfection in vivo. Interestingly, glutathione (GSH) oxidation can be accelerated due to the 808 nm irradiation induced hyperthermia at the presence of PEG-MoS2NFs proved by X-ray near-edge absorption spectra and X-ray spectroscopy. The accelerated GSH oxidation can result in bacterial death more easily. A mechanism based on ·OH-enhanced PTT is proposed to explain the antibacterial process.
authors.affiliation: Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences , Beijing, 100049, China.
authors.forename: Wenyan
authors.initials: W
authors.lastname: Yin
authors.affiliation: Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences , Beijing, 100049, China.|Key Laboratory of Polymer Science and Technology, School of Science, Northwestern Polytechnical University , Xi'an, Shaanxi 710129, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Yu
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences , Beijing, 100190, China.
authors.forename: Fengting
authors.initials: F
authors.lastname: Lv
authors.affiliation: Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences , Beijing, 100049, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Yan
authors.affiliation: Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences , Beijing, 100049, China.
authors.forename: Li Rong
authors.initials: LR
authors.lastname: Zheng
authors.affiliation: Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences , Beijing, 100049, China.
authors.forename: Zhanjun
authors.identifier: 0000-0003-3717-2423
authors.initials: Z
authors.lastname: Gu
authors.affiliation: Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences , Beijing, 100049, China.|Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China , Beijing, 100190, China.
authors.forename: Yuliang
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000900:Anti-Bacterial Agents; D004926:Escherichia coli; D006861:Hydrogen Peroxide / Q000737:chemistry; D053761:Nanocomposites; D009195:Peroxidase; D010544:Peroxidases
chemical_list: D000900:Anti-Bacterial Agents; D006861:Hydrogen Peroxide; D010544:Peroxidases; D009195:Peroxidase
keywords: MoS2; peroxidase-like activity; photothermal therapy; wound disinfection