title: 131I-labeled and DOX-loaded multifunctional nanoliposomes for radiotherapy and chemotherapy in brain gliomas.
abstract: The codelivery of different therapeutics is a promising option because of its synergetic effects of drugs. In this study, a new combination therapy that used the doxorubicin-loaded and131I-labeled nanoliposomes (131I-DOX-NL) was proposed to delay tumor growth of gliomas, which are characterized by significant mortality and morbidity.131I-DOX-NL was constructed based on bovine serum albumin (BSA)-tailor made hydrophobic maleimide-functionalized poly(ε-caprolactone) (PCL) (Fig. 1) and was evaluated by cellular viability in vitro and by U87 xenograft models in vivo. Compared with using131I-NL or DOX-NL alone, our experimental results show that131I-DOX-NL exhibits similar high cellular uptake but enhanced efficacy to cure gliomas because of its codelivery of131I and DOX. In the U87 mouse tumor models, the combination therapy resulted in higher survival rates of mice and smaller tumor sizes than monotherapy did alone. In conclusion, multifunctional nanoliposome131I-DOX-NL is a good candidate for the codelivery of131I-mediated radiotherapy and DOX-mediated chemotherapy due to its ability to inhibit U87 cell proliferation and tumor growth.131I-DOX-NL can be used as a promising effective therapy for malignant gliomas and deserves further investigation.
authors.affiliation: Department of Nuclear Medicine, Tianjin Medical University General Hospital, PR China.
authors.forename: Jingmei
authors.initials: J
authors.lastname: Gao
authors.affiliation: Department of Materials Laboratory, School of Life Sciences, Tianjin University, PR China.
authors.forename: Lei
authors.initials: L
authors.lastname: Fang
authors.affiliation: Department of Nuclear Medicine, Tianjin Medical University General Hospital, PR China.
authors.forename: Danyang
authors.initials: D
authors.lastname: Sun
authors.affiliation: Department of Nuclear Medicine, Tianjin Medical University General Hospital, PR China.
authors.forename: Yiming
authors.initials: Y
authors.lastname: Shen
authors.affiliation: Department of Nuclear Medicine, Tianjin Medical University General Hospital, PR China.
authors.forename: Yiming
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Department of Nuclear Medicine, Tianjin Medical University General Hospital, PR China.
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.affiliation: Department of Materials Laboratory, School of Life Sciences, Tianjin University, PR China.
authors.forename: Jin
authors.initials: J
authors.lastname: Chang
authors.affiliation: Department of Nuclear Medicine, Tianjin Medical University General Hospital, PR China. Electronic address: weiwei_tianjin@foxmail.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Nuclear Medicine, Tianjin Medical University General Hospital, PR China. Electronic address: tanpost@163.com.
authors.forename: Jian
authors.initials: J
authors.lastname: Tan
mesh_terms: D000818:Animals; D002208:Caproates / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002681:China; D004317:Doxorubicin / Q000494:pharmacology*; D004338:Drug Combinations; D016503:Drug Delivery Systems / Q000379:methods*; D005260:Female; D005910:Glioma / Q000188:drug therapy*; D007457:Iodine Radioisotopes / Q000494:pharmacology*; D007783:Lactones / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D053769:Nanocapsules / Q000627:therapeutic use; D053758:Nanoparticles / Q000008:administration & dosage; D049329:Nanostructures / Q000627:therapeutic use
chemical_list: D002208:Caproates; D004338:Drug Combinations; D007457:Iodine Radioisotopes; C000614965:Iodine-131; D007783:Lactones; D053769:Nanocapsules; C121056:caprolactone; D004317:Doxorubicin
keywords: Combination therapy; DOX chemotherapy; Malignant glioma; Nanoliposomes; Radioiodine therapy