title: The therapeutic applications of antimicrobial peptides (AMPs): a patent review.
abstract: Antimicrobial peptides (AMPs) are small molecules with a broad spectrum of antibiotic activities against bacteria, yeasts, fungi, and viruses and cytotoxic activity on cancer cells, in addition to anti-inflammatory and immunomodulatory activities. Therefore, AMPs have garnered interest as novel therapeutic agents. Because of the rapid increase in drug-resistant pathogenic microorganisms, AMPs from synthetic and natural sources have been developed using alternative antimicrobial strategies. This article presents a broad analysis of patents referring to the therapeutic applications of AMPs since 2009. The review focuses on the universal trends in the effective design, mechanism, and biological evolution of AMPs.
authors.affiliation: Department of Biomedical Sciences, Chosun University, Gwangju, 61452, Republic of Korea.
authors.forename: Hee-Kyoung
authors.initials: HK
authors.lastname: Kang
authors.affiliation: Department of Bioinformatics, Kongju National University, Kongju, 32588, Republic of Korea.
authors.forename: Cheolmin
authors.initials: C
authors.lastname: Kim
authors.affiliation: Department of Bioinformatics, Kongju National University, Kongju, 32588, Republic of Korea.
authors.forename: Chang Ho
authors.initials: CH
authors.lastname: Seo
authors.affiliation: Department of Biomedical Sciences, Chosun University, Gwangju, 61452, Republic of Korea. y_k_park@chosun.ac.kr.|Research Center for Proteinaceous Materials, Chosun University, Gwangju, 61452, Republic of Korea. y_k_park@chosun.ac.kr.
authors.forename: Yoonkyung
authors.initials: Y
authors.lastname: Park
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D023181:Antimicrobial Cationic Peptides / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D001419:Bacteria / Q000187:drug effects*; D005658:Fungi / Q000187:drug effects*; D006801:Humans; D010330:Patents as Topic; D014780:Viruses / Q000187:drug effects*; D054804:Cathelicidins
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D023181:Antimicrobial Cationic Peptides; D054804:Cathelicidins
keywords: antimicrobial peptide; drug candidate; pathogenic bacteria; therapies