title: Achievements, Challenges, and Opportunities in DNA-Encoded Library Research: An Academic Point of View.
abstract: DNA-encoded chemical libraries (DECLs) are pools of DNA-tagged small molecules that enable facile screening and identification of bio-macromolecule binders. The successful development of DECLs has led to their increasingly important role in drug development, and screening hits have entered clinical trials. In this review, we summarize the development and currently active research areas of DECLs with a focus on contributions from groups at academic institutes. We further look at opportunities and future directions of DECL research in medicinal chemistry and chemical biology based on the symbiotic relationship between academia and industry. Challenges associated with the application of DECLs in academic drug discovery are further discussed.
authors.affiliation: Department of Medicinal Chemistry, University of Utah, 30 S 2000 E, Salt Lake City, UT, 84113, USA.
authors.forename: Lik Hang
authors.identifier: 0000-0002-7011-6485
authors.initials: LH
authors.lastname: Yuen
authors.affiliation: Department of Medicinal Chemistry, University of Utah, 30 S 2000 E, Salt Lake City, UT, 84113, USA.
authors.forename: Raphael M
authors.identifier: 0000-0001-6772-5119
authors.initials: RM
authors.lastname: Franzini
mesh_terms: D000047:Academies and Institutes; D020650:Combinatorial Chemistry Techniques; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D055808:Drug Discovery; D057166:High-Throughput Screening Assays; D019151:Peptide Library; D012106:Research; D054852:Small Molecule Libraries / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D019151:Peptide Library; D054852:Small Molecule Libraries; D004247:DNA
keywords: chemical biology; combinatorial chemistry; drug discovery; encoded libraries; high-throughput screening