title: Non classical Monocytes Levels, Increased by Subcutaneous Fat-Secretome, Are Associated with Less Rehospitalization after Heart Failure Admission.
abstract: Differential monocyte subsets are increased in obesity and heart failure (HF). We studied their role as predictors of rehospitalization for HF and their regulation by adipose tissue. Monocyte subsets and body fat composition were determined from 136 patients at the discharge after HF admission. Regulation of monocytes by SAT secretomes from obese/non-obese patients with HF was studied in a cell culture method. Proteomic analysis of secretome SAT was performed by LC-MALDI TOF/TOF. High CD14-CD16+monocyte levels indicated less rehospitalization for HF (p = 0.018). SAT secretomes from obese patients increased the CD14-CD16+monocytes (11.8 ± 5.3 vs 3.9 ± 2.6%; p < 0.01). Differential proteins were determined between obese and non-obese patients with HF. High levels of CD14-CD16+monocytes are associated with less rehospitalization for HF. This phenotype is upregulated by SAT secretome from obese patients with HF. This mechanism might help us to understand the obesity paradox in HF.
authors.affiliation: Cardiology Group, Health Research Institute, Santiago de Compostela, Spain. sonia.eiras.penas@sergas.es.|Laboratorio 6. IDIS. Planta-2, C/Choupana s/n, Complejo Hospitalario Universitario de Santiago de Compostela, 15706, Santiago de Compostela, Spain. sonia.eiras.penas@sergas.es.
authors.forename: Sonia
authors.initials: S
authors.lastname: Eiras
authors.affiliation: Cardiology Group, Health Research Institute, Santiago de Compostela, Spain.|Cardiovascular Area and Coronary Unit, University Clinical Hospital, Santiago de Compostela, Spain.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Varela-Román
authors.affiliation: Immunology Unit, University Clinical Hospital, Santiago de Compostela, Spain.
authors.forename: Mariléia Cháves
authors.initials: MC
authors.lastname: Andrade
authors.affiliation: Laboratory of Molecular and Cellular Endocrinology, Health Research Institute of Santiago de Compostela and CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Castro
authors.affiliation: Cardiovascular Area and Coronary Unit, University Clinical Hospital, Santiago de Compostela, Spain.
authors.forename: Rocío
authors.initials: R
authors.lastname: González-Ferreiro
authors.affiliation: Immunology Unit, University Clinical Hospital, Santiago de Compostela, Spain.
authors.forename: Juan E
authors.initials: JE
authors.lastname: Viñuela
authors.affiliation: Cardiology Group, Health Research Institute, Santiago de Compostela, Spain.
authors.forename: Ángel
authors.initials: Á
authors.lastname: Fernández-Trasancos
authors.affiliation: Laboratory of Molecular and Cellular Endocrinology, Health Research Institute of Santiago de Compostela and CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.
authors.forename: Marcos C
authors.initials: MC
authors.lastname: Carreira
authors.affiliation: Cardiology Group, Health Research Institute, Santiago de Compostela, Spain.
authors.forename: Ezequiel
authors.initials: E
authors.lastname: Álvarez
authors.affiliation: Laboratory of Molecular and Cellular Endocrinology, Health Research Institute of Santiago de Compostela and CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.
authors.forename: Felipe F
authors.initials: FF
authors.lastname: Casanueva
authors.affiliation: Cardiology Group, Health Research Institute, Santiago de Compostela, Spain.|Cardiovascular Area and Coronary Unit, University Clinical Hospital, Santiago de Compostela, Spain.
authors.forename: José R
authors.initials: JR
authors.lastname: González-Juanatey
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000378:metabolism; D002478:Cells, Cultured; D005260:Female; D058851:GPI-Linked Proteins / Q000378:metabolism; D006333:Heart Failure / Q000175:diagnosis / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D018950:Lipopolysaccharide Receptors / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000145:classification / Q000276:immunology* / Q000378:metabolism; D009765:Obesity / Q000175:diagnosis / Q000276:immunology* / Q000378:metabolism; D010343:Patient Admission; D010359:Patient Readmission; D010641:Phenotype; D011379:Prognosis; D040901:Proteomics / Q000379:methods; D017452:Receptors, IgG / Q000378:metabolism; D012307:Risk Factors; D050151:Subcutaneous Fat / Q000276:immunology* / Q000378:metabolism
chemical_list: D015415:Biomarkers; C428200:FCGR3B protein, human; D058851:GPI-Linked Proteins; D018950:Lipopolysaccharide Receptors; D017452:Receptors, IgG
keywords: Adipose tissue; Heart failure; Monocytes