title: Helicobacter pylori infection is an independent risk factor for colonic adenomatous neoplasms.
abstract: Helicobacter pylori infection is considered to have a positive association with colorectal neoplasms. In this study, we evaluated the association between H. pylori infection and colorectal adenomas, based on the characteristics of these adenomas in Korea, where the prevalence of H. pylori infection is high and the incidence of colorectal cancer continues to increase.
  
  
  
  The study cohort consisted of 4,466 subjects who underwent colonoscopy and esophagogastroduodenoscopy during screening (1,245 colorectal adenomas vs. 3,221 polyp-free controls). We compared the rate of H. pylori infection between patients with adenoma and polyp-free control cases, using multivariable logistic regression analysis.
  
  
  
  The overall rate of positive H. pylori infection was higher in adenoma cases than in polyp-free control cases (55.0 vs. 48.5%, p < 0.001). The odds ratio (OR) of positive H. pylori infection in patients with adenoma compared to polyp-free controls was 1.28 (95% CI 1.11-1.47). The positive association of H. pylori infection with colorectal adenomas was more prominent in advanced adenomas (OR 1.84, 95% CI 1.25-2.70) and multiple adenomas (OR 1.72, 95% CI 1.26-2.35). Based on the location of these adenomas, the OR was significant only in patients with colonic adenomas (OR 1.31, 95% CI 1.13-1.52) and not in those with rectal adenoma (OR 0.85, 95% CI 0.58-1.24).
  
  
  
  Helicobacter pylori infection is an independent risk factor for colonic adenomas, especially in cases of advanced or multiple adenomas, but not for rectal adenomas.
authors.affiliation: Center for Cancer Prevention and Detection, National Cancer Center, Goyang-si, Republic of Korea.
authors.forename: Ji Hyung
authors.initials: JH
authors.lastname: Nam
authors.affiliation: Center for Cancer Prevention and Detection, National Cancer Center, Goyang-si, Republic of Korea. hong@ncc.re.kr.|Center for Colorectal Cancer, National Cancer Center, Goyang-si, Republic of Korea. hong@ncc.re.kr.
authors.forename: Chang Won
authors.initials: CW
authors.lastname: Hong
authors.affiliation: Center for Cancer Prevention and Detection, National Cancer Center, Goyang-si, Republic of Korea.|Center for Colorectal Cancer, National Cancer Center, Goyang-si, Republic of Korea.
authors.forename: Byung Chang
authors.initials: BC
authors.lastname: Kim
authors.affiliation: Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.|Molecular Epidemiology Branch, Research Institute, National Cancer Center, Goyang-si, Republic of Korea.
authors.forename: Aesun
authors.initials: A
authors.lastname: Shin
authors.affiliation: Center for Cancer Prevention and Detection, National Cancer Center, Goyang-si, Republic of Korea.
authors.forename: Kum Hei
authors.initials: KH
authors.lastname: Ryu
authors.affiliation: Center for Cancer Prevention and Detection, National Cancer Center, Goyang-si, Republic of Korea.
authors.forename: Bum Joon
authors.initials: BJ
authors.lastname: Park
authors.affiliation: Center for Cancer Prevention and Detection, National Cancer Center, Goyang-si, Republic of Korea.|Center for Colorectal Cancer, National Cancer Center, Goyang-si, Republic of Korea.
authors.forename: Bun
authors.initials: B
authors.lastname: Kim
authors.affiliation: Center for Cancer Prevention and Detection, National Cancer Center, Goyang-si, Republic of Korea.|Center for Colorectal Cancer, National Cancer Center, Goyang-si, Republic of Korea.
authors.forename: Dae Kyung
authors.initials: DK
authors.lastname: Sohn
authors.affiliation: Center for Cancer Prevention and Detection, National Cancer Center, Goyang-si, Republic of Korea.|Center for Colorectal Cancer, National Cancer Center, Goyang-si, Republic of Korea.
authors.forename: Kyung Su
authors.initials: KS
authors.lastname: Han
authors.affiliation: Molecular Epidemiology Branch, Research Institute, National Cancer Center, Goyang-si, Republic of Korea.
authors.forename: Jeongseon
authors.initials: J
authors.lastname: Kim
authors.affiliation: Center for Cancer Prevention and Detection, National Cancer Center, Goyang-si, Republic of Korea.
authors.forename: Chan Wha
authors.initials: CW
authors.lastname: Lee
mesh_terms: D000236:Adenoma / Q000453:epidemiology / Q000209:etiology*; D000328:Adult; D000368:Aged; D003110:Colonic Neoplasms / Q000453:epidemiology / Q000209:etiology*; D003111:Colonic Polyps / Q000453:epidemiology / Q000209:etiology*; D003113:Colonoscopy; D005260:Female; D016481:Helicobacter Infections / Q000150:complications* / Q000453:epidemiology; D016480:Helicobacter pylori; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D056910:Republic of Korea; D012307:Risk Factors
keywords: Adenoma; Colonoscopy; H. Pylori; Risk factor