title: Lymphocyte-to-monocyte ratio is associated with prognosis of diffuse large B-cell lymphoma: correlation with CD163 positive M2 type tumor-associated macrophages, not PD-1 positive tumor-infiltrating lymphocytes.
abstract: The research aims to examine the prognostic value of the lymphocyte-to-monocyte ratio (LMR), neutrophil-to- lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in diffuse large B-cell lymphoma (DLBCL). The relation of these hematologic indicators to poor antitumor immunity and prognosis must be investigated. Clinicopathologic data and survival information of 355 patients with DLBCL was retrospectively analyzed. Univariate analysis revealed that lower LMR (<2.71), higher NLR (≥2.81), CD163+ M2 tumor-associated macrophages (TAM) content ≥9.5% and programmed cell death 1 (PD-1)+ tumor-infiltrating lymphocytes (TILs) content < 4.5 cells per high power field(HPF) were significantly related to unfavorable overall survival (OS) and progression free survival (PFS). When considering the prognostic indexes of IPI, multivariate analysis confirmed that LMR of <2.71 and CD163+ M2 TAM content ≥9.5% significantly affected the prognosis of DLBCL. Spearman correlation test showed LMR was negatively correlated with CD163+ M2 TAM content. However, there were no correlation was found between LMR and PD-1+ TIL as well as between NLR and PD-1+ TIL content. These results indicated that decreased LMR lead to a weak anti-tumor immunity and could be used as a bad prognosis biomarker of DLBCL.
authors.affiliation: Department of Medical Oncology, The Third Affiliated Hospital of Harbin Medicial University, Harbin 150040, China.
authors.forename: Jingxuan
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Medical Oncology, The Third Affiliated Hospital of Harbin Medicial University, Harbin 150040, China.
authors.forename: Kun
authors.initials: K
authors.lastname: Gao
authors.affiliation: Department of Medical Oncology, The Third Affiliated Hospital of Harbin Medicial University, Harbin 150040, China.
authors.forename: Wanting
authors.initials: W
authors.lastname: Lei
authors.affiliation: Department of Medical Oncology, The Third Affiliated Hospital of Harbin Medicial University, Harbin 150040, China.
authors.forename: Lina
authors.initials: L
authors.lastname: Dong
authors.affiliation: Department of Medical Oncology, The Third Affiliated Hospital of Harbin Medicial University, Harbin 150040, China.
authors.forename: Qijia
authors.initials: Q
authors.lastname: Xuan
authors.affiliation: Department of Pathology, The Third Affiliated Hospital of Harbin Medical University, Harbin 150040, China.
authors.forename: Meiyan
authors.initials: M
authors.lastname: Feng
authors.affiliation: Department of Medical Oncology, The Third Affiliated Hospital of Harbin Medicial University, Harbin 150040, China.
authors.forename: Jinlu
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Medical Oncology, The Third Affiliated Hospital of Harbin Medicial University, Harbin 150040, China.
authors.forename: Xiangnan
authors.initials: X
authors.lastname: Ye
authors.affiliation: Department of Medical Oncology, The Third Affiliated Hospital of Harbin Medicial University, Harbin 150040, China.
authors.forename: Tuan
authors.initials: T
authors.lastname: Jin
authors.affiliation: Logistics University of People's Armed Police Force, Tianjin 300162, China.
authors.forename: Zhongbai
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Medical Oncology, The Third Affiliated Hospital of Harbin Medicial University, Harbin 150040, China.
authors.forename: Qingyuan
authors.initials: Q
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000276:immunology; D015214:Antigens, Differentiation, Myelomonocytic / Q000276:immunology; D019540:Area Under Curve; D014408:Biomarkers, Tumor / Q000276:immunology*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000276:immunology* / Q000473:pathology; D008264:Macrophages / Q000276:immunology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology / Q000473:pathology; D011379:Prognosis; D012372:ROC Curve; D011956:Receptors, Cell Surface / Q000276:immunology; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D055815:Young Adult; D000098902:CD163 Antigen
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D014408:Biomarkers, Tumor; D000098902:CD163 Antigen; D011956:Receptors, Cell Surface
keywords: diffuse large B-cell lymphoma (DLBCL); lymphocyte-to-monocyte ratio (LMR); neutrophil-to-lymphocyte ratio (NLR); programmed cell death-1 (PD-1); tumor-associated macrophages