title: MR Fingerprinting of Adult Brain Tumors: Initial Experience.
abstract: MR fingerprinting allows rapid simultaneous quantification of T1 and T2 relaxation times. This study assessed the utility of MR fingerprinting in differentiating common types of adult intra-axial brain tumors.
  
  
  
  MR fingerprinting acquisition was performed in 31 patients with untreated intra-axial brain tumors: 17 glioblastomas, 6 World Health Organization grade II lower grade gliomas, and 8 metastases. T1, T2 of the solid tumor, immediate peritumoral white matter, and contralateral white matter were summarized within each ROI. Statistical comparisons on mean, SD, skewness, and kurtosis were performed by using the univariate Wilcoxon rank sum test across various tumor types. Bonferroni correction was used to correct for multiple-comparison testing. Multivariable logistic regression analysis was performed for discrimination between glioblastomas and metastases, and area under the receiver operator curve was calculated.
  
  
  
  Mean T2 values could differentiate solid tumor regions of lower grade gliomas from metastases (mean, 172 ± 53 ms, and 105 ± 27 ms, respectively;P= .004, significant after Bonferroni correction). The mean T1 of peritumoral white matter surrounding lower grade gliomas differed from peritumoral white matter around glioblastomas (mean, 1066 ± 218 ms, and 1578 ± 331 ms, respectively;P= .004, significant after Bonferroni correction). Logistic regression analysis revealed that the mean T2 of solid tumor offered the best separation between glioblastomas and metastases with an area under the curve of 0.86 (95% CI, 0.69-1.00;P< .0001).
  
  
  
  MR fingerprinting allows rapid simultaneous T1 and T2 measurement in brain tumors and surrounding tissues. MR fingerprinting-based relaxometry can identify quantitative differences between solid tumor regions of lower grade gliomas and metastases and between peritumoral regions of glioblastomas and lower grade gliomas.
authors.affiliation: From the Department of Radiology (C.B., S.D., D.M., S.P., J.S., M.G., V.G.), University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, Ohio chaitra.badve@uhhospitals.org.
authors.forename: C
authors.identifier: 0000-0001-8547-8019
authors.initials: C
authors.lastname: Badve
authors.affiliation: School of Medicine (A.Y., M.R., Z.L.).
authors.forename: A
authors.identifier: 0000-0003-3422-4283
authors.initials: A
authors.lastname: Yu
authors.affiliation: From the Department of Radiology (C.B., S.D., D.M., S.P., J.S., M.G., V.G.), University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, Ohio.
authors.forename: S
authors.identifier: 0000-0003-0977-4080
authors.initials: S
authors.lastname: Dastmalchian
authors.affiliation: School of Medicine (A.Y., M.R., Z.L.).
authors.forename: M
authors.identifier: 0000-0001-7886-2223
authors.initials: M
authors.lastname: Rogers
authors.affiliation: From the Department of Radiology (C.B., S.D., D.M., S.P., J.S., M.G., V.G.), University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, Ohio.
authors.forename: D
authors.identifier: 0000-0003-1664-9579
authors.initials: D
authors.lastname: Ma
authors.affiliation: Department of Biomedical Engineering (Y.J., M.G., V.G.).
authors.forename: Y
authors.identifier: 0000-0001-5010-2265
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Department of Epidemiology and Biostatistics (S.M., M.S.), Case Western Reserve University, Cleveland, Ohio.
authors.forename: S
authors.identifier: 0000-0001-5663-8319
authors.initials: S
authors.lastname: Margevicius
authors.affiliation: From the Department of Radiology (C.B., S.D., D.M., S.P., J.S., M.G., V.G.), University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, Ohio.
authors.forename: S
authors.identifier: 0000-0002-3219-874X
authors.initials: S
authors.lastname: Pahwa
authors.affiliation: School of Medicine (A.Y., M.R., Z.L.).
authors.forename: Z
authors.identifier: 0000-0002-0003-9189
authors.initials: Z
authors.lastname: Lu
authors.affiliation: Department of Epidemiology and Biostatistics (S.M., M.S.), Case Western Reserve University, Cleveland, Ohio.
authors.forename: M
authors.identifier: 0000-0001-7803-0670
authors.initials: M
authors.lastname: Schluchter
authors.affiliation: From the Department of Radiology (C.B., S.D., D.M., S.P., J.S., M.G., V.G.), University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, Ohio.
authors.forename: J
authors.identifier: 0000-0002-3227-8715
authors.initials: J
authors.lastname: Sunshine
authors.affiliation: From the Department of Radiology (C.B., S.D., D.M., S.P., J.S., M.G., V.G.), University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, Ohio.|Department of Biomedical Engineering (Y.J., M.G., V.G.).
authors.forename: M
authors.identifier: 0000-0002-3011-6747
authors.initials: M
authors.lastname: Griswold
authors.affiliation: Departments of Neurosurgery and Pathology (A.S.), University Hospitals-Cleveland Medical Center, Seidman Cancer Center and the Case Comprehensive Cancer Center, Cleveland, Ohio.
authors.forename: A
authors.identifier: 0000-0001-9607-5063
authors.initials: A
authors.lastname: Sloan
authors.affiliation: From the Department of Radiology (C.B., S.D., D.M., S.P., J.S., M.G., V.G.), University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, Ohio.|Department of Biomedical Engineering (Y.J., M.G., V.G.).
authors.forename: V
authors.identifier: 0000-0003-0889-5999
authors.initials: V
authors.lastname: Gulani
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018709:Statistics, Nonparametric