title: Prenatal Alcohol Exposure in Rodents As a Promising Model for the Study of ADHD Molecular Basis.
abstract: A physiological parallelism, or even a causal effect relationship, can be deducted from the analysis of the main characteristics of the "Alcohol Related Neurodevelopmental Disorders" (ARND), derived from prenatal alcohol exposure (PAE), and the behavioral performance in the Attention-deficit/hyperactivity disorder (ADHD). These two clinically distinct disease entities, exhibits many common features. They affect neurological shared pathways, and also related neurotransmitter systems. We briefly review here these parallelisms, with their common and uncommon characteristics, and with an emphasis in the subjacent molecular mechanisms of the behavioral manifestations, that lead us to propose that PAE in rats can be considered as a suitable model for the study of ADHD.
authors.affiliation: Departamento de Ciencias Ambientales, Centro Universitario de Ciencias Biológicas y Agropecuarias, Instituto de Neurociencias, Universidad de Guadalajara Guadalajara, Mexico.
authors.forename: Argelia E
authors.initials: AE
authors.lastname: Rojas-Mayorquín
authors.affiliation: Departamento de Ciencias Ambientales, Centro Universitario de Ciencias Biológicas y Agropecuarias, Instituto de Neurociencias, Universidad de Guadalajara Guadalajara, Mexico.
authors.forename: Edgar
authors.initials: E
authors.lastname: Padilla-Velarde
authors.affiliation: Departamento de Biología Molecular y Genómica, Instituto de Investigación en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara Guadalajara, Mexico.
authors.forename: Daniel
authors.initials: D
authors.lastname: Ortuño-Sahagún
keywords: ADHD; alcohol; animal model; fetal alcohol spectrum disorders; prenatal alcohol exposure