title: Deregulation of Adenosine Receptors in Psoriatic Epidermis: An Option for Therapeutic Treatment.
abstract: Purinergic signaling is involved in psoriasis, a chronic skin disease characterized by increased epidermis cell growth. In particular, Andrés et al. focus on the keratinocyte biology modulated by adenosine receptors providing evidence that the A2Bsubtype plays a prominent role in the reduction of keratinocyte proliferation whereas A2Aand A2Bagonists have antiinflammatory effects independent of adenosine receptors. The authors report that psoriatic epidermis presents a deregulated adenosine receptor expression profile with reduced A2Band increased A2A.
authors.affiliation: Department of Medical Sciences, University of Ferrara, Via Fossato di Mortara, Ferrara, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Merighi
authors.affiliation: Department of Medical Sciences, University of Ferrara, Via Fossato di Mortara, Ferrara, Italy. Electronic address: bpa@unife.it.
authors.forename: Pier Andrea
authors.initials: PA
authors.lastname: Borea
authors.affiliation: Department of Medical Sciences, University of Ferrara, Via Fossato di Mortara, Ferrara, Italy. Electronic address: vrk@unife.it.
authors.forename: Katia
authors.initials: K
authors.lastname: Varani
authors.affiliation: Department of Medical Sciences, University of Ferrara, Via Fossato di Mortara, Ferrara, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Gessi
mesh_terms: D000241:Adenosine / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects / Q000235:genetics; D002478:Cells, Cultured; D015536:Down-Regulation; D004817:Epidermis / Q000187:drug effects / Q000473:pathology; D005786:Gene Expression Regulation; D006801:Humans; D015603:Keratinocytes / Q000166:cytology / Q000187:drug effects*; D058990:Molecular Targeted Therapy; D011565:Psoriasis / Q000188:drug therapy / Q000235:genetics*; D058906:Purinergic P1 Receptor Agonists / Q000494:pharmacology*; D018047:Receptors, Purinergic P1 / Q000235:genetics*
chemical_list: D058906:Purinergic P1 Receptor Agonists; D018047:Receptors, Purinergic P1; D000241:Adenosine