title: Changed Hub and Corresponding Functional Connectivity of Subgenual Anterior Cingulate Cortex in Major Depressive Disorder.
abstract: Major depressive disorder (MDD) is one of the most prevalent mental disorders. In the brain, the hubs of the brain network play a key role in integrating and transferring information between different functional modules. However, whether the changed pattern in functional network hubs contributes to the onset of MDD remains unclear. Using resting-state functional magnetic resonance imaging (rs-fMRI) and graph theory methods, we investigated whether alterations of hubs can be detected in MDD. First, we constructed the whole-brain voxel-wise functional networks and calculated a functional connectivity strength (FCS) map in each subject in 34 MDD patients and 34 gender-, age- and education level-matched healthy controls (HCs). Next, the two-samplet-test was applied to compare the FCS maps between HC and MDD patients and identified significant decrease of FCS in subgenual anterior cingulate cortex (sgACC) in MDD patients. Subsequent functional connectivity analyses of sgACC showed disruptions in functional connectivity with posterior insula, middle and inferior temporal gyrus, lingual gyrus and cerebellum in MDD patients. Furthermore, the changed FCS of sgACC and functional connections to sgACC were significantly correlated with the Hamilton Depression Rating Scale (HDRS) scores in MDD patients. The results of the present study revealed the abnormal hub of sgACC and its corresponding disrupted frontal-limbic-visual cognitive-cerebellum functional networks in MDD. These findings may provide a new insight for the diagnosis and treatment of MDD.
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of ChinaChengdu, China; Department of Radiology, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital)Guangzhou, China.
authors.forename: Huawang
authors.initials: H
authors.lastname: Wu
authors.affiliation: Beijing Key Laboratory of Learning and Cognition, School of Education, Capital Normal University Beijing, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Sun
authors.affiliation: Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences Shenzhen, China.
authors.forename: Jinping
authors.initials: J
authors.lastname: Xu
authors.affiliation: Sichuan Applied Psychology Research Centre, Chengdu Medical College Chengdu, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wu
authors.affiliation: School of Psychology and Sociology, Shenzhen University Shenzhen, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.affiliation: Beijing Key Laboratory of Learning and Cognition, School of Education, Capital Normal University Beijing, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Xiao
authors.affiliation: Department of Psychiatry, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital) Guangzhou, China.
authors.forename: Shenglin
authors.initials: S
authors.lastname: She
authors.affiliation: Department of Radiology, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital) Guangzhou, China.
authors.forename: Jianwei
authors.initials: J
authors.lastname: Huang
authors.affiliation: Department of Radiology, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital) Guangzhou, China.
authors.forename: Wenjin
authors.initials: W
authors.lastname: Zou
authors.affiliation: Department of Clinical Psychology, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital) Guangzhou, China.
authors.forename: Hongjun
authors.initials: H
authors.lastname: Peng
authors.affiliation: Department of Psychiatry, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital) Guangzhou, China.
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Lu
authors.affiliation: Department of Radiology, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital) Guangzhou, China.
authors.forename: Guimao
authors.initials: G
authors.lastname: Huang
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China Chengdu, China.
authors.forename: Tianzi
authors.initials: T
authors.lastname: Jiang
authors.affiliation: Department of Neurology, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital) Guangzhou, China.
authors.forename: Yuping
authors.initials: Y
authors.lastname: Ning
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China Chengdu, China.
authors.forename: Jiaojian
authors.initials: J
authors.lastname: Wang
keywords: functional connectivity strength; hub; major depressive disorder; resting-state; subgenual anterior cingulate cortex