title: Chemical Structure and Surface Modification of Dendritic Nanomaterials Tailored for Therapeutic and Diagnostic Applications.
abstract: Dendritic nanomaterials have attracted a great deal of scientific interest due to their high capacity for multifunctionalization and potential in various biomedical applications, such as drug/gene delivery and diagnostic systems. Depending on the molecular structure and starting monomers, several different types of dendrimers have been developed, including poly(amidoamine) (PAMAM), poly(propylenimine) (PPI), and poly(L-lysine) (PLL) dendrimers, in addition to modified dendritic nanomaterials, such as Janus dendrimers and dendritic block copolymers. The chemical structure and surface modification of dendritic nanomaterials have been found to play a critical role in governing their biological behaviors. In this review, we present a comprehensive overview focusing on the synthesis and chemical structures of dendrimers and modified dendritic nanomaterials that are currently being investigated for drug delivery, gene delivery, and diagnostic applications. In addition, the impact of chemical surface modification and functionalization to the dendritic nanomaterials on their therapeutic and diagnostic applications are highlighted.
authors.affiliation: Departments of a Biopharmaceutical Sciences and b Bioengineering, University of Illinois, Chicago, IL, 60612, United States.
authors.forename: Ja Hye
authors.initials: JH
authors.lastname: Myung
authors.affiliation: Departments of Biopharmaceutical Sciences and Bioengineering, University of Illinois, Chicago, IL, 60612, United States.
authors.forename: Hao-Jui
authors.initials: HJ
authors.lastname: Hsu
authors.affiliation: Departments of Biopharmaceutical Sciences and Bioengineering, University of Illinois, Chicago, IL, 60612, United States.
authors.forename: Jason
authors.initials: J
authors.lastname: Bugno
authors.affiliation: Departments of Biopharmaceutical Sciences and Bioengineering, University of Illinois, Chicago, IL, 60612, United States.
authors.forename: Kevin A
authors.initials: KA
authors.lastname: Tam
authors.affiliation: Department of Biopharmaceutical Sciences, University of Illinois, Chicago, IL, United States.|Department of Bioengineering, University of Illinois, Chicago, IL, United States.|Division of Integrated Science and Engineering, Yonsei University, Seoul, 120-749, Korea.|Department of Integrated OMICS for Biomedical Science, Yonsei University, Seoul, 120-749, Korea.|Pharmaceutical Sciences Division, University of Wisconsin, Madison, WI, 53705, USA.
authors.forename: Seungpyo
authors.initials: S
authors.lastname: Hong
mesh_terms: D000818:Animals; D050091:Dendrimers / Q000737:chemistry*; D019937:Diagnostic Techniques and Procedures; D016503:Drug Delivery Systems; D018014:Gene Transfer Techniques; D006801:Humans; D015394:Molecular Structure; D049329:Nanostructures / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D050091:Dendrimers
keywords: Dendrimers; Dendritic nanomaterials; Dendrons; Diagnostics; Drug delivery; Gene delivery