title: Influence of air quality on the results of in vitro fertilization attempts: A retrospective study.
abstract: OBJECTIVE
  To assess the influence of air quality on the results of IVF.
  
  
  METHODS
  We performed a retrospective study on 292 patients who have undergone an IVF attempt from April 2012 to December 2015 in our French university hospital. Patients were included in the study if data on the air quality at home and at work were available and if they haven't been gone for more than 4days in a month. Data were recorded during the 3 months before oocyte collection and 1 month after embryo transfer. Air quality measurements were obtained from the Observatoire Régional de l'Air en Midi-Pyrénées (ORAMIP) and concerned the levels of nitrogen dioxide (NO2), ozone (O3), particulate matter PM10 and SO2measured every day.
  
  
  RESULTS
  Acute exposures to high levels NO2or PM10 were associated with lower results of IVF (ovarian response to stimulation, number of top embryos) while these parameters were enhanced when patients were exposed to high levels of O3during the first 2 months of folliculogenesis. These effects were found even for a short exposure (1day).
  
  
  CONCLUSIONS
  Air quality has an impact on global health and also on the reproductive function and public and authorities must be aware of environmental protection.
authors.affiliation: Médecine de la Reproduction, CHU Toulouse, 330 avenue de Grande Bretagne, 31059 Toulouse, France.
authors.forename: Julie
authors.initials: J
authors.lastname: Carré
authors.affiliation: Médecine de la Reproduction, CHU Toulouse, 330 avenue de Grande Bretagne, 31059 Toulouse, France; Groupe de Recherche en Fertilité Humaine EA 3694, Université Paul Sabatier, 31059 Toulouse, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Gatimel
authors.affiliation: Médecine de la Reproduction, CHU Toulouse, 330 avenue de Grande Bretagne, 31059 Toulouse, France.
authors.forename: Jessika
authors.initials: J
authors.lastname: Moreau
authors.affiliation: Médecine de la Reproduction, CHU Toulouse, 330 avenue de Grande Bretagne, 31059 Toulouse, France; Groupe de Recherche en Fertilité Humaine EA 3694, Université Paul Sabatier, 31059 Toulouse, France. Electronic address: parinaud.j@chu-toulouse.fr.
authors.forename: Jean
authors.initials: J
authors.lastname: Parinaud
authors.affiliation: Médecine de la Reproduction, CHU Toulouse, 330 avenue de Grande Bretagne, 31059 Toulouse, France; Groupe de Recherche en Fertilité Humaine EA 3694, Université Paul Sabatier, 31059 Toulouse, France.
authors.forename: Roger
authors.initials: R
authors.lastname: Leandri
mesh_terms: D000328:Adult; D000393:Air Pollutants / Q000633:toxicity; D000397:Air Pollution / Q000009:adverse effects*; D005260:Female; D005307:Fertilization in Vitro / Q000706:statistics & numerical data*; D006801:Humans; D009585:Nitrogen Dioxide / Q000633:toxicity; D010062:Ovulation Induction / Q000706:statistics & numerical data*; D010126:Ozone / Q000633:toxicity; D052638:Particulate Matter / Q000633:toxicity; D012189:Retrospective Studies
chemical_list: D000393:Air Pollutants; D052638:Particulate Matter; D010126:Ozone; D009585:Nitrogen Dioxide
keywords: Air quality; IVF; Implantation; Nitrogen dioxide; Ovarian function; Ozone; Particulate matter