title: Platelet-derived growth factor receptors (PDGFRs) fusion genes involvement in hematological malignancies.
abstract: OBJECTIVE
  To investigate oncogenic platelet-derived growth factor receptor(PDGFR) fusion genes involvement in hematological malignancies, the advances in the PDGFR fusion genes diagnosis and development of PDGFR fusions inhibitors.
  
  
  METHODS
  Literature search was done using terms "PDGFR and Fusion" or "PDGFR and Myeloid neoplasm" or 'PDGFR and Lymphoid neoplasm' or "PDGFR Fusion Diagnosis" or "PDGFR Fusion Targets" in databases including PubMed, ASCO.org, and Medscape.
  
  
  RESULTS
  Out of the 36 fusions detected, ETV6(TEL)-PDGFRB and FIP1L1-PDGFRA fusions were frequently detected, 33 are as a result of chromosomal translocation, FIP1L1-PDGFRA and EBF1-PDGFRB are the result of chromosomal deletion and CDK5RAP2- PDGFRΑ is the result of chromosomal insertion. Seven of the 34 rare fusions have detectable reciprocals.
  
  
  CONCLUSIONS
  RNA aptamers are promising therapeutic target of PDGFRs and diagnostic tools of PDGFRs fusion genes. Also, PDGFRs have variable prospective therapeutic strategies including small molecules, RNA aptamers, and interference therapeutics as well as development of adaptor protein Lnk mimetic drugs.
authors.affiliation: Department of Physiology, School of Medicine, Jiangsu University, No. 301 Xuefu Road, Zhenjiang, Jiangsu 212013, People's Republic of China; Department of Applied Biology, University for Development Studies, Navrongo, Ghana. Electronic address: kappiah@uds.ed.gh.
authors.forename: Kwaku
authors.initials: K
authors.lastname: Appiah-Kubi
authors.affiliation: Department of Physiology, School of Medicine, Jiangsu University, No. 301 Xuefu Road, Zhenjiang, Jiangsu 212013, People's Republic of China.
authors.forename: Ting
authors.initials: T
authors.lastname: Lan
authors.affiliation: Department of Physiology, School of Medicine, Jiangsu University, No. 301 Xuefu Road, Zhenjiang, Jiangsu 212013, People's Republic of China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Physiology, School of Medicine, Jiangsu University, No. 301 Xuefu Road, Zhenjiang, Jiangsu 212013, People's Republic of China.
authors.forename: Hai
authors.initials: H
authors.lastname: Qian
authors.affiliation: Department of Physiology, School of Medicine, Jiangsu University, No. 301 Xuefu Road, Zhenjiang, Jiangsu 212013, People's Republic of China.
authors.forename: Min
authors.initials: M
authors.lastname: Wu
authors.affiliation: Basic medical department, Changchun medical college, Changchun, Jilin 130013, People's Republic of China.
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Yao
authors.affiliation: Department of Physiology, School of Medicine, Jiangsu University, No. 301 Xuefu Road, Zhenjiang, Jiangsu 212013, People's Republic of China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Physiology, School of Medicine, Jiangsu University, No. 301 Xuefu Road, Zhenjiang, Jiangsu 212013, People's Republic of China. Electronic address: ycchen54@ujs.edu.cn.
authors.forename: Yongchang
authors.initials: Y
authors.lastname: Chen
mesh_terms: D019337:Hematologic Neoplasms / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D015514:Oncogene Proteins, Fusion / Q000235:genetics* / Q000378:metabolism; D011446:Prospective Studies; D017479:Receptors, Platelet-Derived Growth Factor / Q000235:genetics* / Q000378:metabolism; D014178:Translocation, Genetic
chemical_list: D015514:Oncogene Proteins, Fusion; D017479:Receptors, Platelet-Derived Growth Factor
keywords: Chromosomal translocation; Fusion genes; Lymphoid neoplasm; Myeloid neoplasm; PDGFRs