title: Toxicokinetics of chlordecone in goats: Implications for risk management in French West Indies.
abstract: The former use of chlordecone (CLD) in the French West Indies has resulted in long-term pollution of soils. CLD is known to be potentially transferred towards animal products of animals reared outdoors, mainly through accidental soil ingestion. Several studies indicate that soil bound CLD is bioavailable when administered to farm animals. Currently there is a need to quantify the level of CLD absorption and its toxicokinetic characteristics in the ruminant and particularly in the goat. These are considered as important farm species in the French West Indies. The objective of this study was to evaluate the absorption rate and the half-life of CLD in the non-lactating goat. The goats were administered either intravenously (i.v., n = 6) or orally (p.o., n = 6) one dose (1 mg kg-1body weight) of CLD. Blood samples were collected at defined times up to 160 days post-dosing. CLD was analyzed in serum by high-resolution gas chromatography. A comparison of the area under the serum concentration-time curves (AUC) showed that the i.v. route is equivalent to the oral route. Thus, CLD is considered almost completely absorbed after p.o. administration, as shown by the mean absolute bioavailability. The comparison between the pharmacokinetic profiles of CLD following oral and intravenous dose showed a difference during the first 14 days and a similar kinetic after this period. The half-life of CLD in serum was close to 20 days. These results highlight a possible strategy of decontamination due to the short half-life of CLD, obtained in dry goats that did not excrete fat matter.
authors.affiliation: Université de Lorraine, INRA, USC 340, UR AFPA, 2 avenue de la Forêt de Haye, TSA 40602, 54518, Vandœuvre-lès-Nancy Cedex, France. Electronic address: agnes.fournier@univ-lorraine.fr.
authors.forename: Agnès
authors.initials: A
authors.lastname: Fournier
authors.affiliation: Université de Lorraine, INRA, USC 340, UR AFPA, 2 avenue de la Forêt de Haye, TSA 40602, 54518, Vandœuvre-lès-Nancy Cedex, France.
authors.forename: Cyril
authors.initials: C
authors.lastname: Feidt
authors.affiliation: Université de Lorraine, INRA, USC 340, UR AFPA, 2 avenue de la Forêt de Haye, TSA 40602, 54518, Vandœuvre-lès-Nancy Cedex, France.
authors.forename: Marie-Laure
authors.initials: ML
authors.lastname: Lastel
authors.affiliation: INRA, URZ, UR 143, Domaine Duclos, F-97170, Petit-Bourg, Guadeloupe, France.
authors.forename: Harry
authors.initials: H
authors.lastname: Archimede
authors.affiliation: Université de Liège, LEAE-CART, Allée du 6 Août, 11, 4000, Liège, Belgium.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Thome
authors.affiliation: INRA, URZ, UR 143, Domaine Duclos, F-97170, Petit-Bourg, Guadeloupe, France.
authors.forename: Maurice
authors.initials: M
authors.lastname: Mahieu
authors.affiliation: Université de Lorraine, INRA, USC 340, UR AFPA, 2 avenue de la Forêt de Haye, TSA 40602, 54518, Vandœuvre-lès-Nancy Cedex, France.
authors.forename: Guido
authors.initials: G
authors.lastname: Rychen
mesh_terms: D000818:Animals; D007631:Chlordecone / Q000097:blood / Q000493:pharmacokinetics* / Q000633:toxicity*; D005260:Female; D006041:Goats / Q000097:blood / Q000378:metabolism; D006207:Half-Life; D007306:Insecticides / Q000097:blood / Q000493:pharmacokinetics* / Q000633:toxicity*; D018570:Risk Assessment; D012989:Soil Pollutants / Q000097:blood / Q000493:pharmacokinetics* / Q000633:toxicity*; D066007:Toxicokinetics; D014900:West Indies
chemical_list: D007306:Insecticides; D012989:Soil Pollutants; D007631:Chlordecone
keywords: Absorption; CLD; Goat; Half-life; Serum