title: Validation of the Italian version of the Non Motor Symptoms Scale for Parkinson's disease.
abstract: To validate the adapted Italian version of the Non-Motor Symptoms Scale (NMSS), a tool to assess non-motor symptoms (NMS) in Parkinson's disease (PD).
  
  
  
  A cross cultural adaptation of the NMSS into Italian and a psychometric analysis of the translated version of the NMSS was carried out in patients with PD from two university centres-affiliated hospitals. The quality of data and the acceptability, reliability and construct validity of NMSS were analyzed. The following standard scales were also applied: Hoehn and Yahr staging, Unified Parkinson's Disease Rating Scale (UPDRS) part III, Montreal Cognitive Assessment, Beck Depression Inventory, Neuropsychiatric Inventory, Epworth Sleepiness Scale, Autonomic Scale for Outcomes in Parkinson's disease-Motor, Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale part I and Modified Cumulative Illness Rating Scale (CIRS). Levodopa equivalent daily dose (LEDD) was calculated.
  
  
  
  Seventy-one patients with PD were assessed (mean age years 69.8 ± 9.6 SD; 31% women; mean length of disease 6.3 ± 4.6 years; H&Y median: 2). Mean NMSS was 39.76 (SD 31.9; skewness 0.95). The total score of NMSS was free of floor or ceiling effects and showed a satisfactory reliability (Cronbach's alpha coefficient on total score was 0.72 [range for domains: 0.64-0.73], SEM value was 3.88 [½ SD = 31.90]). Significant positive correlations were found among total NMSS and other NMS standard tests, but no significant correlation appeared with UPDRS part III, CIRS and LEDD.
  
  
  
  The Italian NMSS is a comprehensive and helpful measure for NMS in native Italian patients with PD.
authors.affiliation: Institute of Clinical Neurology, Department of Clinical Sciences, ASST Fatebenefratelli-Sacco, "Luigi Sacco" University Hospital, Milan, Italy; Neurology Unit, Department of Health Sciences, ASST Santi Paolo e Carlo, "San Paolo" University Hospital, Milan, Italy. Electronic address: ilaria.cova@unimi.it.
authors.forename: I
authors.initials: I
authors.lastname: Cova
authors.affiliation: Department of Neurology and Psychiatry (Parkinson's Centre) and Research Centre of Social Diseases (CIMS), "Sapienza" University, Rome, Italy; Cognitive Impairment Center, Local Health Authority 9 of Treviso, Treviso, Italy.
authors.forename: M E
authors.initials: ME
authors.lastname: Di Battista
authors.affiliation: National Centre of Epidemiology, National Institute of Health, Rome, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Vanacore
authors.affiliation: Department of Neurology and Psychiatry (Parkinson's Centre) and Research Centre of Social Diseases (CIMS), "Sapienza" University, Rome, Italy.
authors.forename: C P
authors.initials: CP
authors.lastname: Papi
authors.affiliation: Department of Neurology and Psychiatry (Parkinson's Centre) and Research Centre of Social Diseases (CIMS), "Sapienza" University, Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Alampi
authors.affiliation: Department of Neurology and Psychiatry (Parkinson's Centre) and Research Centre of Social Diseases (CIMS), "Sapienza" University, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Rubino
authors.affiliation: Department of Neurology and Psychiatry (Parkinson's Centre) and Research Centre of Social Diseases (CIMS), "Sapienza" University, Rome, Italy; Parkinson's Clinical Trials Centre [Neurological Centre of Latium (NCL)], Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Valente
authors.affiliation: Department of Neurology and Psychiatry (Parkinson's Centre) and Research Centre of Social Diseases (CIMS), "Sapienza" University, Rome, Italy; Parkinson's Clinical Trials Centre [Neurological Centre of Latium (NCL)], Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Meco
authors.affiliation: Institute of Clinical Neurology, Department of Clinical Sciences, ASST Fatebenefratelli-Sacco, "Luigi Sacco" University Hospital, Milan, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Contri
authors.affiliation: National Centre of Epidemiology, National Institute of Health, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Di Pucchio
authors.affiliation: National Centre of Epidemiology, National Institute of Health, Rome, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Lacorte
authors.affiliation: Neurology Unit, Department of Health Sciences, ASST Santi Paolo e Carlo, "San Paolo" University Hospital, Milan, Italy; Department of Health Sciences, University of Milan, Fondazione IRCCS Ca' Granda, Milan, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Priori
authors.affiliation: Institute of Clinical Neurology, Department of Clinical Sciences, ASST Fatebenefratelli-Sacco, "Luigi Sacco" University Hospital, Milan, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Mariani
authors.affiliation: Institute of Clinical Neurology, Department of Clinical Sciences, ASST Fatebenefratelli-Sacco, "Luigi Sacco" University Hospital, Milan, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Pomati
mesh_terms: D000368:Aged; D000978:Antiparkinson Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007558:Italy; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000592:standards; D010300:Parkinson Disease / Q000150:complications* / Q000188:drug therapy; D011569:Psychiatric Status Rating Scales / Q000592:standards; D011594:Psychometrics / Q000379:methods / Q000592:standards; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D014175:Translating
chemical_list: D000978:Antiparkinson Agents; D007980:Levodopa
keywords: NMSS; Non Motor Symptoms; Parkinson's disease; Validation