title: Inflammation: A Novel Therapeutic Target/Direction in Atherosclerosis.
abstract: Over the past two decades, the viewpoint of atherosclerosis has been replaced gradually by a lipiddriven, chronic, low-grade inflammatory disease of the arterial wall. Current treatment of atherosclerosis is focused on limiting its risk factors, such as hyperlipidemia or hypertension. However, treatment targeting the inflammatory nature of atherosclerosis is still very limited and deserves further attention to fight atherosclerosis successfully. Here, we review the current development of inflammation and atherosclerosis to discuss novel insights and potential targets in atherosclerosis, and to address drug discovery based on anti-inflammatory strategy in atherosclerotic disease.
authors.affiliation: Department of Pharmacology, College of Pharmacy, Third Military Medical University, Chongqing 400038. China.
authors.forename: Bin
authors.initials: B
authors.lastname: Li
authors.affiliation: Assisted Reproductive Center, The First Affiliated Hospital, Chongqing Medical University, Chongqing 400016. China.
authors.forename: Weihong
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Pharmacology, College of Pharmacy, Third Military Medical University, Chongqing 400038. China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Pharmacology, College of Pharamacy, The Third Military Medical University, P.O. Box: 400038, Chongqing. China.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhou
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D050197:Atherosclerosis / Q000188:drug therapy* / Q000378:metabolism; D055808:Drug Discovery; D006801:Humans; D007249:Inflammation / Q000188:drug therapy*
chemical_list: D000893:Anti-Inflammatory Agents
keywords: Atherosclerosis; drug discovery; inflammation; target identification