title: A new short daily brachytherapy schedule in postoperative endometrial carcinoma. Preliminary results.
abstract: To evaluate the preliminary results of vaginal-cuff relapses (VCR) and complications of a short brachytherapy (BT) schedule in postoperative endometrial carcinoma.
  
  
  
  From September 2011 to December 2014, 102 patients were treated with postoperative BT for endometrial carcinoma. Seventy-four patients received a single 7 Gy dose after external beam irradiation (Group 1), and 28 intermediate-risk patients received three daily fractions of 6 Gy (Group 2). The dose was prescribed at 5 mm from the applicator surface. Toxicity was prospectively evaluated after the objective late effects of normal tissues-subjective, objective, management, analytic scores for vagina and RTOG scores for rectum and bladder.
  
  
  
  χ2and Student's t tests.
  
  
  
  The mean followup was 28.85 months (9.6-58.5) in Group 1 and 31.19 months (7.7-62.3) in Group 2. No VCR was found during followup. Late toxicity: vagina toxicity was developed in 24.32% of the patients in Group 1 (G1-G2) and in 21.4% in Group 2 (G1-G2 but 1 G3). Rectal toxicity appeared in only 2.7% of patients in Group 1 (G1). Neither Group 1 nor Group 2 presented late bladder toxicity. No differences were found in late toxicity between Groups 1 and 2.
  
  
  
  The present short BT schedule was safe in relation to VCR and late toxicity for the followup period studied. These results are similar to those of two larger previous schedules performed in our center in relation to the same point of followup.
authors.affiliation: Radiation Oncology Department, Hospital Clinic I Universitari, Barcelona, Spain; Gynecological Cancer Unit, Hospital Clinic I Universitari, Barcelona, Spain. Electronic address: rovirosa@clinic.ub.es.
authors.forename: Ángeles
authors.initials: Á
authors.lastname: Rovirosa
authors.affiliation: Public Health Department, Faculty of Medicine, University of Barcelona, Barcelona, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Ascaso
authors.affiliation: Radiation Oncology Department, Hospital Clinic I Universitari, Barcelona, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Herreros
authors.affiliation: Economics Department, Hospital Clinic I Universitari, Barcelona, Spain.
authors.forename: Joan
authors.initials: J
authors.lastname: Sánchez
authors.affiliation: Radiation Oncology Department, Hospital Clinic I Universitari, Barcelona, Spain.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Holub
authors.affiliation: Radiation Oncology Department, Hospital San Joan de Reus, Reus, Spain.
authors.forename: Albert
authors.initials: A
authors.lastname: Camarasa
authors.affiliation: Radiation Oncology Department, Hospital General de Albacete, Albacete, Spain.
authors.forename: Sebastià
authors.initials: S
authors.lastname: Sabater
authors.affiliation: Radiation Oncology Department, Hospital Clinic I Universitari, Barcelona, Spain.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Oses
authors.affiliation: Radiation Oncology Department, Hospital Clinic I Universitari, Barcelona, Spain.
authors.forename: Julia
authors.initials: J
authors.lastname: García-Miguel
authors.affiliation: Radiation Oncology Department, Hospital Rebagliati, Lima, Peru.
authors.forename: Yamile
authors.initials: Y
authors.lastname: Rivera
authors.affiliation: Radiation Oncology Department, Hospital San Joan de Reus, Reus, Spain.
authors.forename: Meritxell
authors.initials: M
authors.lastname: Arenas
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000473:pathology / Q000532:radiotherapy*; D000368:Aged; D001918:Brachytherapy / Q000009:adverse effects / Q000379:methods*; D018269:Carcinoma, Endometrioid / Q000473:pathology / Q000532:radiotherapy*; D016889:Endometrial Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D007045:Hysterectomy, Vaginal; D008197:Lymph Node Excision; D008875:Middle Aged; D018297:Neoplasms, Cystic, Mucinous, and Serous / Q000473:pathology / Q000532:radiotherapy*; D010052:Ovariectomy; D011184:Postoperative Period; D011880:Radiotherapy Planning, Computer-Assisted; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects / Q000379:methods*; D012007:Rectum; D001743:Urinary Bladder; D014621:Vagina
keywords: High dose rate; Postoperative endometrial carcinoma; Vaginal-cuff brachytherapy