title: Naphthofuranone derivatives and other constituents from Pachira aquatica with inhibitory activity on superoxide anion generation by neutrophils.
abstract: Two new naphthofuranone derivatives, 11-hydroxy-2-O-methylhibiscolactone A (1) and O-methylhibiscone D (2), have been isolated from the stems of Pachira aquatica, together with 18 known compounds (3-20). The structures of two new compounds were determined through spectroscopic and MS analyses. Among the isolated compounds, 11-hydroxy-2-O-methylhibiscolactone A (1), isohemigossylic acid lactone-7-methyl ether (4), gmelofuran (6), and 5-hydroxyauranetin (8) exhibited inhibition (IC50≤28.84μM) of superoxide anion generation by human neutrophils in response to N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP).
authors.affiliation: School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
authors.forename: Lin-Yang
authors.initials: LY
authors.lastname: Cheng
authors.affiliation: Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
authors.forename: Hsiang-Ruei
authors.initials: HR
authors.lastname: Liao
authors.affiliation: Department of Pharmacy, Tajen University, Pingtung 90741, Taiwan; Department of Pharmacy, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung 81342, Taiwan.
authors.forename: Li-Chai
authors.initials: LC
authors.lastname: Chen
authors.affiliation: Department of Medicine, Mackay Medical College, New Taipei City 25245, Taiwan.
authors.forename: Shih-Wei
authors.initials: SW
authors.lastname: Wang
authors.affiliation: Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 40402, Taiwan; Department of Biotechnology, Asia University, Taichung 41354, Taiwan.
authors.forename: Yueh-Hsiung
authors.initials: YH
authors.lastname: Kuo
authors.affiliation: School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
authors.forename: Mei-Ing
authors.initials: MI
authors.lastname: Chung
authors.affiliation: Department of Pharmacy, Tajen University, Pingtung 90741, Taiwan; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 40447, Taiwan. Electronic address: jjchen@tajen.edu.tw.
authors.forename: Jih-Jung
authors.initials: JJ
authors.lastname: Chen
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000302:isolation & purification; D035161:Bombacaceae / Q000737:chemistry*; D002478:Cells, Cultured; D005663:Furans / Q000737:chemistry* / Q000302:isolation & purification; D006801:Humans; D015394:Molecular Structure; D009240:N-Formylmethionine Leucyl-Phenylalanine; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D013481:Superoxides / Q000378:metabolism*; D055815:Young Adult
chemical_list: D000893:Anti-Inflammatory Agents; D005663:Furans; D010936:Plant Extracts; D013481:Superoxides; D009240:N-Formylmethionine Leucyl-Phenylalanine
keywords: Anti-inflammatory activity; Bombacaceae; Naphthofuranone; Pachira aquatica; Structure elucidation