title: Synthesis, Characterization, and Bactericidal Evaluation of Chitosan/Guanidine Functionalized Graphene Oxide Composites.
abstract: In response to the wide spread of microbial contamination induced by bacterial pathogens, the development of novel materials with excellent antibacterial activity is of great interest. In this study, novel antibacterial chitosan (CS) and polyhexamethylene guanidine hydrochloride (PHGC) dual-polymer-functionalized graphene oxide (GO) (GO-CS-PHGC) composites were designed and easily fabricated. The as-prepared materials were characterized by Fourier transform infrared (FTIR), X-ray photoelectron spectrometer (XPS), field emission scanning electron microscopy (FE-SEM), transmission electron microscope (TEM), thermogravimetric analysis (TGA) and Raman spectroscopy. Their antibacterial capability towards bacterial strains was also studied by incubating both Gram-negative bacteria and Gram-positive bacteria in their presence. More significantly, the synergistic antibacterial action of the three components was assayed, and the findings implied that the as-prepared GO-CS-PHGC shows enhanced antibacterial activity when compared to its single components (GO, CS, PHGC or CS-PHGC) and the mixture of individual components. Not only Gram-negative bacteria but also Gram-positive bacteria are greatly inhibited by GO-CS-PHGC composites. The minimum inhibitory concentration (MIC) value of GO-CS-PHGC againstE. coliwas 32 μg/mL. With the powerful antibacterial activity as well as its low cost and facile preparation, GO-CS-PHGC has potential applications as a novel antibacterial agent in a wide range of biomedical uses.
authors.affiliation: College of Chemistry, Jilin University, Changchun 130021, China. lping19@126.com.
authors.forename: Ping
authors.initials: P
authors.lastname: Li
authors.affiliation: College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, China. tangyu2209@163.com.
authors.forename: Yangyang
authors.initials: Y
authors.lastname: Gao
authors.affiliation: College of Chemistry, Jilin University, Changchun 130021, China. liuzhenguang1234@163.com.
authors.forename: Zijia
authors.initials: Z
authors.lastname: Sun
authors.affiliation: College of Chemistry, Jilin University, Changchun 130021, China. changdan15@mails.jlu.edu.cn.
authors.forename: Dan
authors.initials: D
authors.lastname: Chang
authors.affiliation: College of Chemistry, Jilin University, Changchun 130021, China. gaoge@jlu.edu.cn.
authors.forename: Ge
authors.initials: G
authors.lastname: Gao
authors.affiliation: College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, China. dongali@imu.edu.cn.
authors.forename: Alideertu
authors.initials: A
authors.lastname: Dong
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D048271:Chitosan / Q000737:chemistry / Q000494:pharmacology*; D004357:Drug Synergism; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D006108:Graphite / Q000737:chemistry / Q000494:pharmacology*; D006146:Guanidines / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D010087:Oxides; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development
chemical_list: D000900:Anti-Bacterial Agents; D006146:Guanidines; D010087:Oxides; C060540:polyhexamethyleneguanidine; D006108:Graphite; D048271:Chitosan
keywords: antibacterial activity; chitosan; graphene oxide; polyhexamethylene guanidine hydrochloride