title: Sinonasal Renal Cell-Like Carcinoma: Case Report and Review of the Literature.
abstract: The differential diagnosis for clear cell neoplasms of the sinonasal tract is wide but critical to understand. In this paper, we describe a case of renal cell-like adenocarcinoma (SNRCLA) presenting as a paranasal sinus mass with clear cell morphology. The relevant literature is reviewed and the workup for clear cell neoplasms described. SNRCLA is a rarely encountered low grade glandular malignancy of the paranasal sinuses. Despite its morphologic mimicry of renal cell carcinoma, SNRCLA demonstrates a seromucinous phenotype and is associated with a favorable prognosis and low recurrence rates after surgical resection.
authors.affiliation: Department of Otolaryngology, Center for Cranial Base Surgery, University of Pittsburgh Medical Center, 200 Lothrop Street, EEI 521, Pittsburgh, PA, 15213, USA. kubikmw@upmc.edu.
authors.forename: Mark
authors.identifier: http://orcid.org/0000-0002-8646-9920
authors.initials: M
authors.lastname: Kubik
authors.affiliation: Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Barasch
authors.affiliation: Department of Otolaryngology, Center for Cranial Base Surgery, University of Pittsburgh Medical Center, 200 Lothrop Street, EEI 521, Pittsburgh, PA, 15213, USA.
authors.forename: Garret
authors.initials: G
authors.lastname: Choby
authors.affiliation: Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
authors.forename: Raja
authors.initials: R
authors.lastname: Seethala
authors.affiliation: Department of Otolaryngology, Center for Cranial Base Surgery, University of Pittsburgh Medical Center, 200 Lothrop Street, EEI 521, Pittsburgh, PA, 15213, USA.
authors.forename: Carl
authors.initials: C
authors.lastname: Snyderman
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000473:pathology*; D000369:Aged, 80 and over; D002292:Carcinoma, Renal Cell / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D010255:Paranasal Sinus Neoplasms / Q000473:pathology*
keywords: Clear Cell; Clear Cell Carcinoma; Clear Cell Renal Cell Carcinoma; Paranasal Sinus; Renal Cell Carcinoma