title: Obese individuals with more components of the metabolic syndrome and/or prediabetes demonstrate decreased activation of reward-related brain centers in response to food cues in both the fed and fasting states: a preliminary fMRI study.
abstract: It remains unknown whether obese individuals with more components of the metabolic syndrome and/or prediabetes demonstrate altered activation of brain centers in response to food cues. We examined obese individuals with prediabetes (n=26) vs obese individuals without prediabetes (n=11) using fMRI. We also performed regression analyses on the basis of the number of MetS components per subject. Obese individuals with prediabetes have decreased activation of the reward-related putamen in the fasting state and decreased activation of the salience- and reward-related insula after eating. Obese individuals with more components of MetS demonstrate decreased activation of the putamen while fasting. All these activations remain significant when corrected for BMI, waist circumference (WC), HbA1c and gender. Decreased activation in the reward-related central nervous system areas among the obese is more pronounced in subjects with prediabetes and MetS. Prospective studies are needed to quantify their contributions to the development of prediabetes/MetS and to study whether they may predispose to the exacerbation of obesity and the development of comorbidities over time.
authors.affiliation: Division of Endocrinology, Department of Medicine, Beth-Israel Deaconess Medical Center/Harvard Medical School, Boston, MAUSA.
authors.forename: O M
authors.initials: OM
authors.lastname: Farr
authors.affiliation: Division of Endocrinology, Department of Medicine, Beth-Israel Deaconess Medical Center/Harvard Medical School, Boston, MAUSA.
authors.forename: C S
authors.initials: CS
authors.lastname: Mantzoros
mesh_terms: D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D003463:Cues; D005215:Fasting / Q000502:physiology*; D005260:Female; D005502:Food; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications* / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000473:pathology / Q000503:physiopathology*; D010775:Photic Stimulation; D011236:Prediabetic State / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D011446:Prospective Studies; D012201:Reward; D012307:Risk Factors; D055105:Waist Circumference
chemical_list: D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human