title: MicroRNAs 142-3p, miR-155 and miR-203 Are Deregulated in Gastric MALT Lymphomas Compared to Chronic Gastritis.
abstract: Over the last years, our knowledge on pathogenesis of gastric MALT lymphoma has greatly improved, but its morphological diagnosis is still hampered by overlapping histological features with advanced chronic gastritis. MicroRNAs are deregulated in lymphomas, but their role and usefulness in gastric MALT lymphoma has not been extensively investigated.
  
  
  
  We analyzed the expression of 384 miRNAs using TaqMan microRNA assay in a training series of 10 gastric MALT lymphomas, 3 chronic gastritis and 2 reactive lymph nodes. Then, significantly deregulated miRNAs were individually assessed by real-time PCR in a validation series of 16 gastric MALT lymphomas and 12 chronic gastritis.
  
  
  
  Gastric MALT lymphoma is characterized by a specific miRNA expression profile. Among the differentially expressed miRNAs, a significant overexpression of miR-142-3p and miR-155 and down-regulation of miR-203 was observed in gastric MALT lymphoma when compared to chronic gastritis.
  
  
  
  miR-142-3p, miR-155 and miR-203 expression levels might be helpful biomarkers for the differential diagnosis between gastric MALT lymphomas and chronic gastritis.
authors.affiliation: Pathology Department, Hospital del Mar, Barcelona, Spain.|IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.|Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Concepción
authors.initials: C
authors.lastname: Fernández
authors.affiliation: Pathology Department, Hospital del Mar, Barcelona, Spain bbellosillo@parcdesalutmar.cat.|IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.|Universitat Pompeu Fabra, Barcelona, Spain.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Bellosillo
authors.affiliation: Universitat Autònoma de Barcelona, Barcelona, Spain.|Hematology Department, Hospital del Mar, Barcelona, Spain.
authors.forename: Mariana
authors.initials: M
authors.lastname: Ferraro
authors.affiliation: Digestive Department, Hospital del Mar, Barcelona, Spain.
authors.forename: Agustín
authors.initials: A
authors.lastname: Seoane
authors.affiliation: IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.|Hematology Department, Hospital del Mar, Barcelona, Spain.
authors.forename: Blanca
authors.initials: B
authors.lastname: Sánchez-González
authors.affiliation: Pathology Department, Hospital del Mar, Barcelona, Spain.|IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.
authors.forename: Silvia
authors.initials: S
authors.lastname: Pairet
authors.affiliation: IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.
authors.forename: Aina
authors.initials: A
authors.lastname: Pons
authors.affiliation: Digestive Department, Hospital del Mar, Barcelona, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Barranco
authors.affiliation: Pathology Department, Hospital del Mar, Barcelona, Spain.
authors.forename: María Carmen
authors.initials: MC
authors.lastname: Vela
authors.affiliation: IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.|Hematology Department, Hospital del Mar, Barcelona, Spain.
authors.forename: Eva
authors.initials: E
authors.lastname: Gimeno
authors.affiliation: Pathology Department, Hospital del Mar, Barcelona, Spain.
authors.forename: Lluís
authors.initials: L
authors.lastname: Colomo
authors.affiliation: IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.|Hematology Department, Hospital del Mar, Barcelona, Spain.
authors.forename: Carles
authors.initials: C
authors.lastname: Besses
authors.affiliation: Molecular Oncology and Embryology Laboratory, Human Anatomy Unit, School of Medicine, University of Barcelona, IDIBAPS, Barcelona, Spain.
authors.forename: Alfons
authors.initials: A
authors.lastname: Navarro
authors.affiliation: IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.|Universitat Autònoma de Barcelona, Barcelona, Spain.|Hematology Department, Hospital del Mar, Barcelona, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Salar
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers; D002908:Chronic Disease; D016000:Cluster Analysis; D005260:Female; D005756:Gastritis / Q000175:diagnosis / Q000235:genetics* / Q000382:microbiology; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000175:diagnosis / Q000235:genetics*; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D009367:Neoplasm Staging; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000235:genetics*; D059467:Transcriptome
chemical_list: D015415:Biomarkers; C555159:MIRN142 microRNA, human; C524942:MIRN155 microRNA, human; C546703:MIRN203 microRNA, human; D035683:MicroRNAs
keywords: MicroRNAs; chronic gastritis; gastric MALT lymphoma; miR-155; miR-203