title: One Health proof of concept: Bringing a transdisciplinary approach to surveillance for zoonotic viruses at the human-wild animal interface.
abstract: As the world continues to react and respond inefficiently to emerging infectious diseases, such as Middle Eastern Respiratory Syndrome and the Ebola and Zika viruses, a growing transdisciplinary community has called for a more proactive and holistic approach to prevention and preparedness - One Health. Such an approach presents important opportunities to reduce the impact of disease emergence events and also to mitigate future emergence through improved cross-sectoral coordination. In an attempt to provide proof of concept of the utility of the One Health approach, the US Agency for International Development's PREDICT project consortium designed and implemented a targeted, risk-based surveillance strategy based not on humans as sentinels of disease but on detecting viruses early, at their source, where intervention strategies can be implemented before there is opportunity for spillover and spread in people or food animals. Here, we share One Health approaches used by consortium members to illustrate the potential for successful One Health outcomes that can be achieved through collaborative, transdisciplinary partnerships. PREDICT's collaboration with partners around the world on strengthening local capacity to detect hundreds of viruses in wild animals, coupled with a series of cutting-edge virological and analytical activities, have significantly improved our baseline knowledge on the zoonotic pool of viruses and the risk of exposure to people. Further testament to the success of the project's One Health approach and the work of its team of dedicated One Health professionals are the resulting 90 peer-reviewed, scientific publications in under 5 years that improve our understanding of zoonoses and the factors influencing their emergence. The findings are assisting in global health improvements, including surveillance science, diagnostic technologies, understanding of viral evolution, and ecological driver identification. Through its One Health leadership and multi-disciplinary partnerships, PREDICT has forged new networks of professionals from the human, animal, and environmental health sectors to promote global health, improving our understanding of viral disease spillover from wildlife and implementing strategies for preventing and controlling emerging disease threats.
authors.affiliation: One Health Institute & Karen C. Drayer Wildlife Health Center, School of Veterinary Medicine, 1089 Veterinary Medicine Drive, University of California, Davis, CA, 95616, USA. Electronic address: trkelly@ucdavis.edu.
authors.forename: Terra R
authors.initials: TR
authors.lastname: Kelly
authors.affiliation: EcoHealth Alliance, 460 West 34th Street, 17th Floor, New York, NY, 10001, USA. Electronic address: karesh@ecohealthalliance.org.
authors.forename: William B
authors.initials: WB
authors.lastname: Karesh
authors.affiliation: One Health Institute & Karen C. Drayer Wildlife Health Center, School of Veterinary Medicine, 1089 Veterinary Medicine Drive, University of California, Davis, CA, 95616, USA. Electronic address: ckjohnson@ucdavis.edu.
authors.forename: Christine Kreuder
authors.initials: CK
authors.lastname: Johnson
authors.affiliation: One Health Institute & Karen C. Drayer Wildlife Health Center, School of Veterinary Medicine, 1089 Veterinary Medicine Drive, University of California, Davis, CA, 95616, USA. Electronic address: kvgilardi@ucdavis.edu.
authors.forename: Kirsten V K
authors.initials: KV
authors.lastname: Gilardi
authors.affiliation: EcoHealth Alliance, 460 West 34th Street, 17th Floor, New York, NY, 10001, USA; Center for Infection and Immunity, Mailman School of Public Health, Columbia University, 722 West 168th Street, New York, NY, 10032, USA. Electronic address: sja2127@cumc.columbia.edu.
authors.forename: Simon J
authors.initials: SJ
authors.lastname: Anthony
authors.affiliation: One Health Institute & Karen C. Drayer Wildlife Health Center, School of Veterinary Medicine, 1089 Veterinary Medicine Drive, University of California, Davis, CA, 95616, USA. Electronic address: tgoldstein@ucdavis.edu.
authors.forename: Tracey
authors.initials: T
authors.lastname: Goldstein
authors.affiliation: Wildlife Conservation Society, 2300 Southern Blvd., Bronx, New York, NY, 10460, USA. Electronic address: solson@wcs.org.
authors.forename: Sarah H
authors.initials: SH
authors.lastname: Olson
authors.affiliation: EcoHealth Alliance, 460 West 34th Street, 17th Floor, New York, NY, 10001, USA. Electronic address: Machalaba@ecohealthalliance.org.
authors.forename: Catherine
authors.initials: C
authors.lastname: Machalaba
authors.affiliation: One Health Institute & Karen C. Drayer Wildlife Health Center, School of Veterinary Medicine, 1089 Veterinary Medicine Drive, University of California, Davis, CA, 95616, USA. Electronic address: jkmazet@ucdavis.edu.
authors.forename: Jonna A K
authors.initials: JA
authors.lastname: Mazet
mesh_terms: D000818:Animals; D000835:Animals, Wild; D021821:Communicable Diseases, Emerging / Q000453:epidemiology / Q000209:etiology / Q000662:veterinary*; D014943:Global Health; D006801:Humans; D018571:Sentinel Surveillance / Q000662:veterinary*; D015047:Zoonoses / Q000453:epidemiology* / Q000209:etiology
keywords: Emerging infectious disease; Human-wildlife interface; One Health; Surveillance; Wildlife; Zoonotic