title: The role of human epididymis secretory protein E4 in patients with endometrial cancer and premalignant endometrial lesions.
abstract: We evaluated the concentrations of human epididymis secretory protein E4 (HE4) and Ca-125 in relation to clinicopathologic features in patients with endometrial cancer and premalignant endometrial lesions. Women with abnormal uterine bleeding (n = 167) who underwent endometrial sampling were divided into four groups. Group 1: endometrial cancer (n = 68), group 2: atypical endometrial hyperplasia (n = 12), group 3: endometrial hyperplasia without atypia (n = 39) and group 4: controls (n = 48). Women with endometrial cancer exhibited higher concentrations of HE4 levels than controls (91.4 pmol/L vs. 46.2 pmol/L, p < 0.001). HE4 levels were significantly higher in patients with lymphatic involvement, deep myometrial invasion, lymphovascular space involvement and non-endometrioid histology (p < 0.001). The sensitivity, specificity, positive and negative predictive values for HE4 in detecting endometrial cancer were 72.7%, 84.4%, 80% and 78.4%, respectively. Preoperative HE4 levels are more elevated in women with endometrial cancer than those with benign endometrium as well as in women with prognostic high-risk factors with endometrial cancer. HE4 may be used as an additional marker in combination with other clinicopathologic features for planning the treatment.
authors.affiliation: a Department of Gynecology & Obstetrics , Selçuk University Faculty of Medicine , Konya , Turkey.
authors.forename: Setenay Arzu
authors.initials: SA
authors.lastname: Yılmaz
authors.affiliation: b Department of Gynecology & Obstetrics , Faculty of Adnan Menderes University , Aydın , Turkey.
authors.forename: Sündüz Özlem
authors.initials: SÖ
authors.lastname: Altınkaya
authors.affiliation: a Department of Gynecology & Obstetrics , Selçuk University Faculty of Medicine , Konya , Turkey.
authors.forename: Özlem Seçilmiş
authors.initials: ÖS
authors.lastname: Kerimoglu
authors.affiliation: a Department of Gynecology & Obstetrics , Selçuk University Faculty of Medicine , Konya , Turkey.
authors.forename: Aybike
authors.initials: A
authors.lastname: Tazegül Pekin
authors.affiliation: c Department of Biochemistry , Faculty of Selçuk University , Konya , Turkey.
authors.forename: Fikret
authors.initials: F
authors.lastname: Akyürek
authors.affiliation: a Department of Gynecology & Obstetrics , Selçuk University Faculty of Medicine , Konya , Turkey.
authors.forename: Tolgay Tuyan
authors.initials: TT
authors.lastname: Ilhan
authors.affiliation: a Department of Gynecology & Obstetrics , Selçuk University Faculty of Medicine , Konya , Turkey.
authors.forename: Nilgün
authors.initials: N
authors.lastname: Benzer
authors.affiliation: c Department of Biochemistry , Faculty of Selçuk University , Konya , Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Unlu
authors.affiliation: b Department of Gynecology & Obstetrics , Faculty of Adnan Menderes University , Aydın , Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Yuksel
authors.affiliation: a Department of Gynecology & Obstetrics , Selçuk University Faculty of Medicine , Konya , Turkey.
authors.forename: Cetin
authors.initials: C
authors.lastname: Celik
mesh_terms: D000368:Aged; D004714:Endometrial Hyperplasia / Q000097:blood* / Q000601:surgery; D016889:Endometrial Neoplasms / Q000097:blood* / Q000601:surgery; D004717:Endometrium / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D008875:Middle Aged; D011230:Precancerous Conditions / Q000097:blood* / Q000601:surgery; D011237:Predictive Value of Tests; D011379:Prognosis; D011506:Proteins / Q000032:analysis*; D012680:Sensitivity and Specificity; D000081102:WAP Four-Disulfide Core Domain Protein 2
chemical_list: D011506:Proteins; D000081102:WAP Four-Disulfide Core Domain Protein 2; C569698:WFDC2 protein, human
keywords: Endometrial cancer; atypical endometrial hyperplasia; endometrial hyperplasia; endometrial hyperplasia without atypia; human epididymis secretory protein E4