title: Optimal thallium-201 dose in cadmium-zinc-telluride SPECT myocardial perfusion imaging.
abstract: BACKGROUND
  We aimed to determine the optimal thallium 201 chloride (thallium-201) dose using a novel ultrafast cardiac gamma camera with cadmium-zinc-telluride (CZT) solid-state semiconductor detectors (D-SPECT).
  
  
  RESULTS
  The optimal thallium-201 dose for obtaining left ventricular (LV) myocardial counts was determined from a phantom study. Consecutive 292 patients underwent stress myocardial perfusion imaging with a thallium-201 injection. Stress test comprised exercise or pharmacological (adenosine) provocation. We calculated an optimal thallium-201 dose that resulted in better LV myocardial counts during 6 minutes of acquisition time. We corrected the respective values according to the patient's age, sex, body mass index (BMI), and type of stress test. The lowest thallium-201 dose for obtaining acceptable imaging was 1.2 million counts. Radiopharmaceutical doses showed a positive correlation with the patient's age (P < .001), sex (P = .012), BMI (P < .001), and type of stress test (P < .001). Multivariate analysis revealed that the patient's BMI and the type of stress test were statistically significant factors for determining the correct radiopharmaceutical dose (P < .001 for both).
  
  
  CONCLUSIONS
  For clinical use of the CZT SPECT system, the optimal individual thallium-201 doses can be determined based on the patient's BMI and type of stress test.
authors.affiliation: Department of Radiology, Hyogo Brain and Heart Center at Himeji, Himeji, Japan.|Department of Quantum Medical Technology, Graduate School of Medical Sciences, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa, 920-0942, Japan.
authors.forename: Masaru
authors.initials: M
authors.lastname: Ishihara
authors.affiliation: Department of Cardiology, Hyogo Brain and Heart Center at Himeji, Himeji, Japan.
authors.forename: Yasuyo
authors.initials: Y
authors.lastname: Taniguchi
authors.affiliation: Department of Quantum Medical Technology, Graduate School of Medical Sciences, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa, 920-0942, Japan. onoguchi@staff.kanazawa-u.ac.jp.
authors.forename: Masahisa
authors.initials: M
authors.lastname: Onoguchi
authors.affiliation: Department of Quantum Medical Technology, Graduate School of Medical Sciences, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa, 920-0942, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Shibutani
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002104:Cadmium; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D055414:Myocardial Perfusion Imaging; D019047:Phantoms, Imaging; D019275:Radiopharmaceuticals / Q000008:administration & dosage*; D013691:Tellurium; D013794:Thallium Radioisotopes / Q000008:administration & dosage*; D015899:Tomography, Emission-Computed, Single-Photon; D016277:Ventricular Function, Left / Q000502:physiology; D015032:Zinc
chemical_list: C474490:CdZnTe; D019275:Radiopharmaceuticals; D013794:Thallium Radioisotopes; D002104:Cadmium; C000615114:Thallium-201; D015032:Zinc; D013691:Tellurium
keywords: Cadmium-zinc-telluride; Myocardial perfusion imaging; SPECT; Stress test; Thallium-201