title: Assessment of the liver and spleen in children with Gaucher disease type I with diffusion-weighted MR imaging.
abstract: To assess hepatic and splenic apparent diffusion coefficient (ADC) in children with Gaucher disease type I with diffusion-weighted MR imaging and to correlate hepatic and splenic ADC with parameters of disease severity.
  
  
  
  Prospective study was conducted upon 25 children (11 treated and 14 untreated) with Gaucher disease and 12 age and sex matched control children. They underwent diffusion-weighted MR imaging of abdomen. Hepatic and splenic ADC and volume were calculated.
  
  
  
  There was statistically difference in hepatic and splenic apparent diffusion coefficient (P=0.001) between patients and controls. The cutoff ADC of liver and spleen used to differentiate patients from controls were 0.47 and 0.39×10-3mm2with area and curve of 0.947 and 0.886 respectively. There was significant difference in hepatic and splenic ADC between untreated and treated patients (P=0.003 and 0.001). Hepatic ADC correlated with splenic volume (r=-0.721), hepatic volume (r=-0.555) and chitotriosidase (r=-0.413). Splenic ADC correlated with splenic volume (r=-0.652), hepatic volume (r=-0.544) and chitotriosidase (r=-0.355).
  
  
  
  Hepatic and splenic ADC can detect hepatic and splenic infiltration in Gaucher disease and correlated with some parameters of disease severity.
authors.affiliation: Department of Diagnostic Radiology, Mansoura Faculty of Medicine, Mansoura, Egypt. Electronic address: arazek@mans.edu.eg.
authors.forename: Ahmed Abdel Khalek Abdel
authors.initials: AAKA
authors.lastname: Razek
authors.affiliation: Gastroenterology and Hepatology Unit of Mansoura Children Hospital, Mansoura Faculty of Medicine, Mansoura, Egypt.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Abdalla
authors.affiliation: Gastroenterology and Hepatology Unit of Mansoura Children Hospital, Mansoura Faculty of Medicine, Mansoura, Egypt.
authors.forename: Tarik
authors.initials: T
authors.lastname: Barakat
authors.affiliation: Gastroenterology and Hepatology Unit of Mansoura Children Hospital, Mansoura Faculty of Medicine, Mansoura, Egypt.
authors.forename: Heba
authors.initials: H
authors.lastname: El-Taher
authors.affiliation: Department of Pathology, Mansoura Faculty of Medicine, Mansoura, Egypt.
authors.forename: Khadiga
authors.initials: K
authors.lastname: Ali
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D005776:Gaucher Disease / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D009929:Organ Size; D011446:Prospective Studies; D013154:Spleen / Q000000981:diagnostic imaging* / Q000473:pathology
keywords: Diffusion; Gaucher; Liver; MR imaging; Spleen