title: Obesity: An Immunometabolic Perspective.
abstract: Obesity, characterized by chronic activation of inflammatory pathways, is a critical factor contributing to insulin resistance (IR) and type 2 diabetes (T2D). Free fatty acids (FFAs) are increased in obesity and are implicated as proximate causes of IR and induction of inflammatory signaling in adipose, liver, muscle, and pancreas. Cells of the innate immune system produce cytokines, and other factors that affect insulin signaling and result in the development of IR. In the lean state, adipose tissue is populated by adipose tissue macrophage of the anti-inflammatory M2 type (ATM2) and natural killer (NK) cells; this maintains the insulin-sensitive phenotype because ATM2 cells secrete IL10. In contrast, obesity induces lipolysis and release of pro-inflammatory FFAs and factors, such as chemokine (C-C motif) ligand 2 (CCL2) and tumor necrosis factor alpha (TNF-α), which recruit blood monocytes in adipose tissue, where they are converted to macrophages of the highly pro-inflammatory M1-type (ATM1). Activated ATM1 produce large amounts of pro-inflammatory mediators such as TNF-α, interleukin-1β, IL-6, leukotriene B4, nitric oxide (NO), and resistin that work in a paracrine fashion and cause IR in adipose tissue. In the liver, both pro-inflammatory Kupffer cells (M1-KCs) and recruited hepatic macrophages (Ly6Chigh) contribute to decreased hepatic insulin sensitivity. The present mini-review will update the bidirectional interaction between the immune system and obesity-induced changes in metabolism in adipose tissue and liver and the metabolic consequences thereof.
authors.affiliation: Machine Intelligence Unit, Indian Statistical Institute , Kolkata , India.
authors.forename: Indrani
authors.initials: I
authors.lastname: Ray
authors.affiliation: Metabolic Physiology & Ultrastructural Biology Laboratory, VA San Diego Healthcare System, La Jolla, CA, USA; Metabolic Physiology & Ultrastructural Biology Laboratory, University of California San Diego, La Jolla, CA, USA.
authors.forename: Sushil K
authors.initials: SK
authors.lastname: Mahata
authors.affiliation: Machine Intelligence Unit, Indian Statistical Institute , Kolkata , India.
authors.forename: Rajat K
authors.initials: RK
authors.lastname: De
keywords: ER stress; insulin resistance; macrophages; non-alcoholic fatty liver diseases; obesity; reactive oxygen species; type 2 diabetes