title: Characterization of synthesized NANO-encapsulated drug for bone loss on hind limb suspension rat model by NMR and micro-CT.
abstract: A formulation of nano-encapsulated enantiomer of (+) promethazine with desired release rate has been synthesized for establish a localized drug delivery system. It was tested on a hind limb suspension (HLS) disuse rat model, and by using a non-destructive Nuclear Magnetic Resonance (NMR) relaxation technique, and micro computed tomography (Micro-CT) analysis technique to qualitatively evaluate the effectiveness of the new bone formations as well as to compare the current commercial anti-bone loss drug Alendeonate. Our studies suggest that nano-encapsulated (+) promethazine in controlled release formulations conjugating bone-targeting functional groups are effective in promoting bone growth in a disuse rat model.
authors.affiliation: Southwest Research Institute, San Antonio, TX, USA; Texas A&M International University, Laredo, TX, USA.
authors.forename: Qingwen
authors.initials: Q
authors.lastname: Ni
authors.affiliation: Southwest Research Institute, San Antonio, TX, USA.
authors.forename: Hong
authors.initials: H
authors.lastname: Dixon
authors.affiliation: Southwest Research Institute, San Antonio, TX, USA.
authors.forename: Gloria
authors.initials: G
authors.lastname: Gutierrez
authors.affiliation: State University of New York at Stony Brook, Stony Brook NY, USA.
authors.forename: Long
authors.initials: L
authors.lastname: Bi
authors.affiliation: State University of New York at Stony Brook, Stony Brook NY, USA.
authors.forename: Yi-Xian
authors.initials: YX
authors.lastname: Qin
keywords: Bone; Micro-CT; NMR; Nano-Encapsulation