title: Reflex arc of the teeth clenching-induced pressor response in rats.
abstract: Although "teeth clenching" induces pressor response, the reflex tracts of the response are unknown. In this study, dantrolene administration inhibited teeth clenching generated by electrical stimulation of the masseter muscles and completely abolished the pressor response. In addition, trigeminal ganglion block or hexamethonium administration completely abolished the pressor response. Local anesthesia of molar regions significantly reduced the pressor response to 27 ± 10%. Gadolinium (mechanoreceptor blocker of group III muscle afferents) entrapment in masticatory muscles also significantly reduced the pressor response to 62 ± 7%. Although atropine methyl nitrate administration did not change the pressor response, a significant dose-dependent augmentation of heart rate was observed. These results indicate that both periodontal membrane and mechanoreceptors in masticatory muscles are the receptors for the pressor response, and that the afferent and efferent pathways of the pressor response pass through the trigeminal afferent nerves and sympathetic nerves, respectively.
authors.affiliation: Department of Physiology, National Defense Medical College, Namiki 3-2, Tokorozawa, Saitama, 3598513, Japan. doc00035@ndmc.ac.jp.|Department of Oral and Maxillofacial Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan. doc00035@ndmc.ac.jp.
authors.forename: Ichiro
authors.initials: I
authors.lastname: Shoji
authors.affiliation: Department of Physiology, National Defense Medical College, Namiki 3-2, Tokorozawa, Saitama, 3598513, Japan.
authors.forename: Takehito
authors.initials: T
authors.lastname: Kemuriyama
authors.affiliation: Department of Physiology, National Defense Medical College, Namiki 3-2, Tokorozawa, Saitama, 3598513, Japan.
authors.forename: Megumi
authors.initials: M
authors.lastname: Tandai-Hiruma
authors.affiliation: Pharmacochemical Section, Aeromedical Laboratory, Japan Air Self Defense Force, Tachikawa, Tokyo, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Maruyama
authors.affiliation: Department of Physiology, National Defense Medical College, Namiki 3-2, Tokorozawa, Saitama, 3598513, Japan.
authors.forename: Akimasa
authors.initials: A
authors.lastname: Tashiro
authors.affiliation: Department of Oral and Maxillofacial Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan.
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Yokoe
authors.affiliation: Department of Physiology, National Defense Medical College, Namiki 3-2, Tokorozawa, Saitama, 3598513, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Nishida
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology*; D003620:Dantrolene / Q000008:administration & dosage; D004558:Electric Stimulation / Q000379:methods; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D008297:Male; D009475:Neurons, Afferent / Q000187:drug effects / Q000502:physiology; D009476:Neurons, Efferent / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012018:Reflex / Q000187:drug effects / Q000502:physiology*; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000502:physiology; D014070:Tooth / Q000187:drug effects / Q000502:physiology*; D012668:Trigeminal Ganglion / Q000187:drug effects / Q000502:physiology
chemical_list: D003620:Dantrolene
keywords: Mechanoreceptor; Periodontal membrane; Pressor response; Sympathetic nerve; Teeth clenching; Trigeminal afferent nerve