title: Investigation on the association between IL-10 C819T gene polymorphisms and susceptibility to gastric cancer.
abstract: We conducted a case-control study to investigate the association between the interleukin-10 (IL-10) C819T polymorphism and susceptibility to gastric cancer in a Chinese population. A total of 157 patients with gastric cancer and 249 controls were consecutively enrolled from the Guizhou Provincial People's Hospital between October 2012 and February 2015. The polymerase chain reaction-restriction fragment length polymorphism technique was used to genotype for IL-10 C819T. As determined by χ2-test, there was a significant difference in genotype distributions of IL-10 C819T between gastric cancer patients and controls (χ2= 7.09; P = 0.03). Based on unconditional logistic regression analysis, the TT genotype of IL-10 C819T was significantly associated with increased risk of gastric cancer when compared with that of the CC genotype [odds ratio (OR) = 2.24; 95% confidence interval (CI) = 1.17-4.26; P = 0.008]. In a dominant model, we found that the CT + TT genotype of IL-10 C819T was associated with susceptibility to gastric cancer compared to that of the CC genotype (OR = 1.63; 95%CI = 1.02-2.64). In a recessive model, the TT genotype of IL-10 C819T was correlated with a higher risk of gastric cancer when compared with that of the CC + CT genotype (OR = 1.75; 95%CI = 1.01-3.02). In conclusion, our study suggests that the IL-10 C819T polymorphism is associated with an increased risk of gastric cancer in co-dominant, dominant, and recessive models.
authors.affiliation: Gastrointestinal Department of Internal Medicine, Guizhou Provincial People's Hospital, Guiyang, China lilangc@163.com.
authors.forename: L
authors.initials: L
authors.lastname: Li
authors.affiliation: Gastrointestinal Department of Internal Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
authors.forename: X Y
authors.initials: XY
authors.lastname: Tang
authors.affiliation: Gastrointestinal Department of Internal Medicine, Guizhou Provincial People's Hospital, Guiyang, China.
authors.forename: L M
authors.initials: LM
authors.lastname: Ye
authors.affiliation: Gastrointestinal Department of Internal Medicine, Guizhou Provincial People's Hospital, Guiyang, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Yang
authors.affiliation: Gastrointestinal Department of Internal Medicine, Guizhou Provincial People's Hospital, Guiyang, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Li
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012044:Regression Analysis; D013274:Stomach Neoplasms / Q000235:genetics*
chemical_list: C508609:IL10 protein, human; D016753:Interleukin-10