title: Meta-Analysis for the Therapeutic Effect of Neoadjuvant Therapy in Resectable Esophageal Cancer.
abstract: We aimed to review the therapeutic effects of neoadjuvant chemoradiotherapy (NCRT), chemotherapy (NCT), and radiotherapy (NRT) on patients with resectable Esophageal cancer (EsC) by comparison with surgery alone (SA). PubMed, EMBASE and Cochrane were searched for eligible studies published up to March 2015. Cochrane reviews were used for quality assessment. Eight primary outcomes were analyzed. Risk ratios (RRs)/ hazard ratios (HRs) and corresponding 95% confidence intervals (95% CIs) were calculated using the random- or fixed- effects model. Heterogeneity was assessed using the Chi-square-based Q statistic and the I2test. Publication bias was examined by the Begg's funnel plot. Totally 24 articles including 4718 EsC cases were eligible for this meta-analysis. The quality of the literatures was relatively high. Significant difference was found in five-year survival rate (RR = 1.45, 95% CI: 1.17-1.79, P < 0.01) between patients treated with NCT and SA, while the eight enrolled primary outcomes were all statistically different between NCRT and SA, and significant difference was identified in three-year survival between NCRT and NCT (RR = 1.35, 95% CI: 1.14-1.60, P < 0.01). No obvious publication bias was observed. NCRT and NCT provide an obvious benefit for EsC treatment over SA, and NCRT possesses a clear advantage compared with NCT.
authors.affiliation: Department of Gastroenterology, The Second People's Hospital of Liaocheng, Linqing, Shandong, 252600, China.
authors.forename: Yusen
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Department of Emergency, The Second People's Hospital of Liaocheng, Linqing, Shandong, 252600, China. minliu01@126.com.
authors.forename: Min
authors.initials: M
authors.lastname: Liu
authors.affiliation: Department of Gastroenterology, The Second People's Hospital of Liaocheng, Linqing, Shandong, 252600, China.
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Yun
authors.affiliation: Department of Gastroenterology, The Second People's Hospital of Liaocheng, Linqing, Shandong, 252600, China.
authors.forename: Dongmei
authors.initials: D
authors.lastname: Wang
authors.affiliation: Department of Gastroenterology, The Second People's Hospital of Liaocheng, Linqing, Shandong, 252600, China.
authors.forename: Yuhuan
authors.initials: Y
authors.lastname: Bai
authors.affiliation: Department of Gastroenterology, The Second People's Hospital of Liaocheng, Linqing, Shandong, 252600, China.
authors.forename: Guizhi
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Department of Gastroenterology, The Second People's Hospital of Liaocheng, Linqing, Shandong, 252600, China.
authors.forename: Bei
authors.initials: B
authors.lastname: Ji
authors.affiliation: Department of Gastroenterology, The Second People's Hospital of Liaocheng, Linqing, Shandong, 252600, China.
authors.forename: Changchun
authors.initials: C
authors.lastname: Jing
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D059248:Chemoradiotherapy / Q000379:methods; D017024:Chemotherapy, Adjuvant / Q000379:methods; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000628:therapy*; D006801:Humans; D008875:Middle Aged; D020360:Neoadjuvant Therapy / Q000379:methods; D018714:Radiotherapy, Adjuvant / Q000379:methods; D015996:Survival Rate
keywords: Esophageal cancer; Meta-analysis; Neoadjuvant chemoradiotherapy; Neoadjuvant chemotherapy; Neoadjuvant radiotherapy