title: Do cannabinoids have a role to play in Tourettes syndrome?
abstract: It has been suggested that the use of cannabinoids might play a role in the treatment of Tourettes syndrome, but there is no consensus. Searching in Epistemonikos database, which is maintained by screening multiple databases, we identified seven systematic reviews including two randomized trials addressing the question of this article. We extracted data, combined the evidence using meta-analysis and generated a summary of findings following the GRADE approach. We concluded it is not clear whether cannabinoids reduce tics in Tourettes syndrome, and they are probably associated to frequent adverse effects.
authors.affiliation: Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Proyecto Epistemonikos, Santiago, Chile. E-mail: radagabriel@epistemonikos.org. Address: Facultad de Medicina, Pontificia Universidad Católica de Chile, Lira 63, Santiago Centro, Chile.
authors.forename: Karen
authors.initials: K
authors.lastname: García
authors.affiliation: Proyecto Epistemonikos, Santiago, Chile; Programa de Salud Basada en Evidencia, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Departamento de Medicina Interna, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; GRADE working group; The Cochrane Collaboration.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Rada
mesh_terms: D002186:Cannabinoids / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D020323:Tics / Q000188:drug therapy* / Q000209:etiology; D005879:Tourette Syndrome / Q000188:drug therapy* / Q000503:physiopathology; D016896:Treatment Outcome
chemical_list: D002186:Cannabinoids