title: CDC Reaction and Subsequent Cyclization for the Synthesis of 2-Hydroxy-3-alkyl-1,4-naphthoquinones and Pyranonaphthoquinones.
abstract: The metal-free cross-dehydrogenative coupling (CDC) reaction and subsequent cyclization of 2-hydroxy-1,4-naphthoquinone (lawsone) and 1,3-diarylpropene promoted by DDQ has been developed. 2-Hydroxy-3-alkyl-1,4-naphthoquinones and pyranonaphthoquinones with potential pharmaceutical applications are obtained in moderate to good yields. The reaction is also compatible for 4-hydroxycoumarins.
authors.affiliation: College of Pharmaceutical Science, Zhejiang University of Technology , Hangzhou 310014, P. R. China.
authors.forename: Dongping
authors.identifier: 0000-0001-6354-1726
authors.initials: D
authors.lastname: Cheng
authors.affiliation: College of Pharmaceutical Science, Zhejiang University of Technology , Hangzhou 310014, P. R. China.
authors.forename: Lijun
authors.initials: L
authors.lastname: Wu
authors.affiliation: College of Pharmaceutical Science, Zhejiang University of Technology , Hangzhou 310014, P. R. China.
authors.forename: Huawei
authors.initials: H
authors.lastname: Lv
authors.affiliation: College of Chemical Engineering, Zhejiang University of Technology , Hangzhou 310014, P. R. China.
authors.forename: Xiaoliang
authors.initials: X
authors.lastname: Xu
authors.affiliation: College of Pharmaceutical Science, Zhejiang University of Technology , Hangzhou 310014, P. R. China.
authors.forename: Jizhong
authors.initials: J
authors.lastname: Yan