title: Moringa Oleifera leaf extract increases plasma antioxidant status associated with reduced plasma malondialdehyde concentration without hypoglycemia in fasting healthy volunteers.
abstract: OBJECTIVE
  To investigate the effect of Moringa Oleifera leaf extract (MOLE) on plasma glucose concentration and antioxidant status in healthy volunteers.
  
  
  METHODS
  A randomized crossover design was used in this study. Healthy volunteers were randomly assigned to receive either 200 mL of warm water (10 cases) or 200 mL of MOLE (500 mg dried extract, 10 cases). Blood samples were drawn at 0, 30, 60, 90, and 120 min for measuring fasting plasma glucose (FPG), ferric reducing ability of plasma (FRAP), Trolox equivalent antioxidant capacity (TEAC) and malondialdehyde (MDA).
  
  
  RESULTS
  FPG concentration was not signifificantly different between warm water and MOLE. The consumption of MOLE acutely improved both FRAP and TEAC, with increases after 30 min of 30 μmol/L FeSO4equivalents and 0.18 μmol/L Trolox equivalents, respectively. The change in MDA level from baseline was signifificantly lowered after the ingestion of MOLE at 30, 60, and 90 min. In addition, FRAP level was negatively correlated with plasma MDA level after an intake of MOLE.
  
  
  CONCLUSIONS
  MOLE increased plasma antioxidant capacity without hypoglycemia in human. The consumption of MOLE may reduce the risk factors associated with chronic degenerative diseases.
authors.affiliation: Department of Nutrition and Dietetics, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330, Thailand. amppam10@gmail.com.|Research Group of Herbal Medicine for Prevention and Therapeutic of Metabolic Diseases, Chulalongkorn University, Bangkok, 10330, Thailand. amppam10@gmail.com.
authors.forename: Sathaporn
authors.initials: S
authors.lastname: Ngamukote
authors.affiliation: Undergraduate Program in Nutrition and Dietetics, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.
authors.forename: Teerawat
authors.initials: T
authors.lastname: Khannongpho
authors.affiliation: Undergraduate Program in Nutrition and Dietetics, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.
authors.forename: Marent
authors.initials: M
authors.lastname: Siriwatanapaiboon
authors.affiliation: Department of Nutrition and Dietetics, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.
authors.forename: Sukrit
authors.initials: S
authors.lastname: Sirikwanpong
authors.affiliation: The Halal Science Center, Chulalongkorn University, Wangmai, Pathumwan, Bangkok, 10330, Thailand.
authors.forename: Winai
authors.initials: W
authors.lastname: Dahlan
authors.affiliation: Department of Nutrition and Dietetics, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.|Research Group of Herbal Medicine for Prevention and Therapeutic of Metabolic Diseases, Chulalongkorn University, Bangkok, 10330, Thailand.
authors.forename: Sirichai
authors.initials: S
authors.lastname: Adisakwattana
keywords: Moringa Oleifera; Trolox equivalent antioxidant capacity; antioxidant status; ferric reducing ability of plasma; malondialdehyde; plasma glucose