title: New lipid formulation of octenidine dihydrochloride.
abstract: Octenidine dihydrochloride is an effective antiseptic compound which mode of action is based on destabilization plasma membrane of microorganisms. This ensures that microorganisms cannot develop the drug resistance in a straightforward way, as the entire cellular structure, rather than specific molecular target is affected. Since the octenidine is a hydrophobic compound, it requires organic solvent such as phenoxyethanol in order to be effectively administered. However, the presence of phenoxyethanol has strong irritating effect, particularly when applied on open wounds and mucous membranes. Phospholipids are known as neutral excipients free of side effects and in their aggregated form may serve as solvent for octenidine. In this article, we propose a new antiseptic formulation composed of equimolar ratio of lipids and octenidine. The resulting particles are ∼4 nm in diameter showing that their topology is different from that known for liposomes. The new formulation has proven to be equally effective as octenidine dihydrochloride formulation marketed under the name of Octenisept®. The main advantage of the new formulation is that it does not contain phenoxyethanol, which opens new possibilities for broader application spectrum of octenidine, including treatments of mucous membranes and open wounds.
authors.affiliation: a Laboratory for Biophysics of Lipid Aggregates, Faculty of Fundamental Problems of Technology, Wroclaw University of Science and Technology , Wroclaw , Poland.|b Lipid Systems sp z o.o , Wroclaw , Poland , and.
authors.forename: Kamila
authors.initials: K
authors.lastname: Szostak
authors.affiliation: c Department of Cytobiochemistry , Faculty of Biotechnology, University of Wroclaw , Wroclaw, Poland.
authors.forename: Aleksander
authors.initials: A
authors.lastname: Czogalla
authors.affiliation: a Laboratory for Biophysics of Lipid Aggregates, Faculty of Fundamental Problems of Technology, Wroclaw University of Science and Technology , Wroclaw , Poland.|b Lipid Systems sp z o.o , Wroclaw , Poland , and.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Przybyło
authors.affiliation: a Laboratory for Biophysics of Lipid Aggregates, Faculty of Fundamental Problems of Technology, Wroclaw University of Science and Technology , Wroclaw , Poland.|b Lipid Systems sp z o.o , Wroclaw , Poland , and.
authors.forename: Marek
authors.initials: M
authors.lastname: Langner
mesh_terms: D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods*; D004926:Escherichia coli / Q000187:drug effects; D005026:Ethylene Glycols / Q000737:chemistry; D005456:Fluorescent Dyes; D007097:Imines; D008055:Lipids / Q000737:chemistry*; D009092:Mucous Membrane / Q000187:drug effects; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D011725:Pyridines / Q000008:administration & dosage / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry; D013499:Surface Properties
chemical_list: D000891:Anti-Infective Agents, Local; D005026:Ethylene Glycols; D005456:Fluorescent Dyes; D007097:Imines; D008055:Lipids; D011725:Pyridines; D012997:Solvents; C005398:phenoxyethanol; C034213:octenidine
keywords: Octenidine dihydrochloride; antiseptics; lipid aggregate; particulate antiseptics; phenoxyethanol