title: Metabolomics as a Functional Tool in Screening Gastro Intestinal Diseases: Where are we in High Throughput Screening?
abstract: Identifying novel bio markers in gastro intestinal disease is a promising method where a comprehensive analysis of the metabolome is performed. Metabolomics has evolved enormously in the past decade, paving a path in gastro intestinal disease research, especially diseases which lead to high morbidity and mortality. Metabolomics involves identifying metabolites such as anti-oxidants, and amino acids etc., which are screened in the urine, feces and tissue samples. Certain cases employ advanced tools like GC-MS, 1HNMR and GC-MS/SPME which reveal valuable information concerning disease severity and differentiation. In light of escalating health care costs and risky invasive procedures, metabolomics can be chosen as a safe yet precise method for screening diseases like ulcerative colitis, Crohns' disease, celiac disease, and gastro intestinal cancers. The present review focuses on major advancements in gastro intestinal metabolomics, giving attention to which parameters are assessed, and to recent changes in metabolite analysis.
authors.affiliation: Intestinal Mucosal Biology Laboratory, School of Health Sciences , University of Tasmania, Launceston, Launceston TAS 7250, Australia.
authors.forename: Rohit
authors.initials: R
authors.lastname: Gundamaraju
authors.affiliation: Intestinal Mucosal Biology Laboratory, School of Health Sciences , University of Tasmania, Launceston, Launceston TAS 7250, Australia.
authors.forename: Ravichandra
authors.initials: R
authors.lastname: Vemuri
authors.affiliation: Intestinal Mucosal Biology Laboratory, School of Health Sciences , University of Tasmania, Launceston, Launceston TAS 7250, Australia.
authors.forename: Rajaraman
authors.initials: R
authors.lastname: Eri
authors.affiliation: University of Western São Paulo (Unoeste), PresidentePrudente, SP, Brazil.
authors.forename: Hamilton M
authors.initials: HM
authors.lastname: Ishiki
authors.affiliation: UM Nueva Granada, Department of Chemistry, Nueva Granada Campus, Cajica, Colombia.
authors.forename: Ericsson
authors.initials: E
authors.lastname: Coy-Barrera
authors.affiliation: Institute of Science, GITAM University, Visakhapatnam, Andhra Pradesh, India.
authors.forename: Nagendra Sastry
authors.initials: NS
authors.lastname: Yarla
authors.affiliation: Federal University of Paraiba, Campus I 58051-970, Joao Pessoa, PB, Brazil.
authors.forename: Sócrates Golzio
authors.initials: SG
authors.lastname: Dos Santos
authors.affiliation: Federal University of Paraiba, Campus I 58051-970, Joao Pessoa, PB, Brazil.
authors.forename: Mateus Feitosa
authors.initials: MF
authors.lastname: Alves
authors.affiliation: Federal University of Paraiba, Campus I 58051-970, Joao Pessoa, PB, Brazil.
authors.forename: José Maria
authors.initials: JM
authors.lastname: Barbosa Filho
authors.affiliation: Federal University of Paraiba, Campus I 58051-970, Joao Pessoa, PB, Brazil.
authors.forename: Margareth F F M
authors.initials: MFFM
authors.lastname: Diniz
authors.affiliation: Federal University of Paraiba, Campus I 58051-970, Joao Pessoa, PB, Brazil.
authors.forename: Marcus T
authors.initials: MT
authors.lastname: Scotti
authors.affiliation: Federal University of Paraiba, Campus I 58051-970, Joao Pessoa, PB, Brazil.
authors.forename: Luciana
authors.initials: L
authors.lastname: Scotti
mesh_terms: D015415:Biomarkers; D005767:Gastrointestinal Diseases / Q000175:diagnosis* / Q000378:metabolism; D057166:High-Throughput Screening Assays / Q000379:methods; D006801:Humans; D055442:Metabolome; D055432:Metabolomics / Q000379:methods
chemical_list: D015415:Biomarkers
keywords: Celiac disease; Crohns’ disease; Metabolomics; Ulcerative colitis; analysis; gastrointestinal disorders; inflammatory bowel disease; metabolites