title: Demonstrating test-retest reliability of electrophysiological measures for healthy adults in a multisite study of biomarkers of antidepressant treatment response.
abstract: Growing evidence suggests that loudness dependency of auditory evoked potentials (LDAEP) and resting EEG alpha and theta may be biological markers for predicting response to antidepressants. In spite of this promise, little is known about the joint reliability of these markers, and thus their clinical applicability. New standardized procedures were developed to improve the compatibility of data acquired with different EEG platforms, and used to examine test-retest reliability for the three electrophysiological measures selected for a multisite project-Establishing Moderators and Biosignatures of Antidepressant Response for Clinical Care (EMBARC). Thirty-nine healthy controls across four clinical research sites were tested in two sessions separated by about 1 week. Resting EEG (eyes-open and eyes-closed conditions) was recorded and LDAEP measured using binaural tones (1000 Hz, 40 ms) at five intensities (60-100 dB SPL). Principal components analysis of current source density waveforms reduced volume conduction and provided reference-free measures of resting EEG alpha and N1 dipole activity to tones from auditory cortex. Low-resolution electromagnetic tomography (LORETA) extracted resting theta current density measures corresponding to rostral anterior cingulate (rACC), which has been implicated in treatment response. There were no significant differences in posterior alpha, N1 dipole, or rACC theta across sessions. Test-retest reliability was .84 for alpha, .87 for N1 dipole, and .70 for theta rACC current density. The demonstration of good-to-excellent reliability for these measures provides a template for future EEG/ERP studies from multiple testing sites, and an important step for evaluating them as biomarkers for predicting treatment response.
authors.affiliation: Department of Psychiatry, Columbia University College of Physicians & Surgeons and New York State Psychiatric Institute, New York, NY, USA.
authors.forename: Craig E
authors.initials: CE
authors.lastname: Tenke
authors.affiliation: Department of Psychiatry, Columbia University College of Physicians & Surgeons and New York State Psychiatric Institute, New York, NY, USA.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Kayser
authors.affiliation: Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont, Massachusetts, USA.
authors.forename: Pia
authors.initials: P
authors.lastname: Pechtel
authors.affiliation: Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont, Massachusetts, USA.
authors.forename: Christian A
authors.initials: CA
authors.lastname: Webb
authors.affiliation: Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont, Massachusetts, USA.
authors.forename: Daniel G
authors.initials: DG
authors.lastname: Dillon
authors.affiliation: Center For Depression, Anxiety and Stress Research, McLean Hospital, Belmont, Massachusetts, USA.
authors.forename: Franziska
authors.initials: F
authors.lastname: Goer
authors.affiliation: Center For Depression, Anxiety and Stress Research, McLean Hospital, Belmont, Massachusetts, USA.
authors.forename: Laura
authors.initials: L
authors.lastname: Murray
authors.affiliation: Departments of Psychology and Psychiatry, University of Michigan Health System, Ann Arbor, Michigan, USA.
authors.forename: Patricia
authors.initials: P
authors.lastname: Deldin
authors.affiliation: Department of Psychiatry, UT Southwestern Medical Center, Dallas, Texas, USA.
authors.forename: Benji T
authors.initials: BT
authors.lastname: Kurian
authors.affiliation: Department of Psychiatry, Columbia University College of Physicians & Surgeons and New York State Psychiatric Institute, New York, NY, USA.
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: McGrath
authors.affiliation: Department of Psychiatry, SUNY Stony Brook, Stony Brook, New York, USA.
authors.forename: Ramin
authors.initials: R
authors.lastname: Parsey
authors.affiliation: Department of Psychiatry, UT Southwestern Medical Center, Dallas, Texas, USA.
authors.forename: Madhukar
authors.initials: M
authors.lastname: Trivedi
authors.affiliation: Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont, Massachusetts, USA.|Depression Clinical and Research Program, Massachusetts General Hospital, Boston, Massachusetts, USA.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Fava
authors.affiliation: Department of Psychiatry, Columbia University College of Physicians & Surgeons and New York State Psychiatric Institute, New York, NY, USA.
authors.forename: Myrna M
authors.initials: MM
authors.lastname: Weissman
authors.affiliation: Departments of Psychology and Psychiatry, University of Michigan Health System, Ann Arbor, Michigan, USA.
authors.forename: Melvin
authors.initials: M
authors.lastname: McInnis
authors.affiliation: Department of Psychiatry, Columbia University College of Physicians & Surgeons and New York State Psychiatric Institute, New York, NY, USA.
authors.forename: Karen
authors.initials: K
authors.lastname: Abraham
authors.affiliation: Department of Psychiatry, Columbia University College of Physicians & Surgeons and New York State Psychiatric Institute, New York, NY, USA.
authors.forename: Jorge
authors.initials: J
authors.lastname: E Alvarenga
authors.affiliation: Department of Psychiatry, Columbia University College of Physicians & Surgeons and New York State Psychiatric Institute, New York, NY, USA.
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Alschuler
authors.affiliation: Department of Psychiatry, UT Southwestern Medical Center, Dallas, Texas, USA.
authors.forename: Crystal
authors.initials: C
authors.lastname: Cooper
authors.affiliation: Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont, Massachusetts, USA.
authors.forename: Diego A
authors.initials: DA
authors.lastname: Pizzagalli
authors.affiliation: Department of Psychiatry, Columbia University College of Physicians & Surgeons and New York State Psychiatric Institute, New York, NY, USA.
authors.forename: Gerard E
authors.initials: GE
authors.lastname: Bruder
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D000513:Alpha Rhythm; D000928:Antidepressive Agents / Q000627:therapeutic use*; D001303:Auditory Cortex / Q000502:physiology; D015415:Biomarkers; D002540:Cerebral Cortex / Q000502:physiology*; D004569:Electroencephalography / Q000379:methods*; D005072:Evoked Potentials, Auditory; D005260:Female; D006179:Gyrus Cinguli / Q000502:physiology; D006801:Humans; D008297:Male; D025341:Principal Component Analysis; D015203:Reproducibility of Results; D012815:Signal Processing, Computer-Assisted; D013826:Theta Rhythm
chemical_list: D000928:Antidepressive Agents; D015415:Biomarkers
keywords: Biomarkers; EEG; Evoked potentials; LORETA; Reliability; Surface Laplacian