title: Clinical, Histopathological and Molecular Characteristics of Metastatic Breast Cancer in North-Eastern Kazakhstan: a 10 Year Retrospective Study
abstract: Background: Breast cancer (BC) is the top cancer among women worldwide and has been the most frequent
  malignancy among Kazakhstan women over the past few decades. Information on clinical and histopathological
  features of metastatic breast cancer (MBC), as well as the distribution of molecular subtypes is limited for Kazakh
  people. Materials and Methods: The present observational retrospective study was carried out at Regional Oncologic
  Dispensaries in the North-East Region of Kazakhstan (in Semey and Pavlodar cities). Сlinical and histopathological
  data were obtained for a total of 570 MBC patients in the 10 year period from 2004-2013, for whom data on molecular
  subtype were available for 253. Data from hospital charts were entered into SPSS 20 for analysis by one-way ANOVA
  analysis of associations of different variables with 1-5 year survival. Pearson correlation and linear regression models
  were used to examine the relation between parameters with a p-value < 0.05 considered statistically significant. Results:
  No significant relationships were evident between molecular subtype and survival, site of metastases, stage or ethnicity.
  Young females below the age of 44 were slightly more likely to have triple negative lesions. While the ductal type
  greatly predomonated, luminal A and B cases had a higher percentage with lobular morphology. Conclusions: In this
  select group of metastatice brease cancer, no links were noted for survival with molecular subtype, in contrast to much
  of the literature.
authors.affiliation: Semey State Medical University, Semey,Kazakhstan. Email:ai_samina@mail.ru
authors.forename: Aizhan
authors.initials: A
authors.lastname: Abiltayeva
authors.forename: Malcolm Anthony
authors.initials: MA
authors.lastname: Moore
authors.forename: Ayan
authors.initials: A
authors.lastname: Myssayev
authors.forename: Tasbolat
authors.initials: T
authors.lastname: Adylkhanov
authors.forename: Ainur
authors.initials: A
authors.lastname: Baissalbayeva
authors.forename: Kuantkan
authors.initials: K
authors.lastname: Zhabagin
authors.forename: Eldar
authors.initials: E
authors.lastname: Beysebayev
keywords: Breast cancer; molecular subtypes; mortality; metastasis; North-East Kazakhstan