title: Direct Assembly of Prenylated Heteroarenes through a Cascade Minisci Reaction/Dehydration Sequence.
abstract: The prenyl group is an important component in bioactive compounds. Herein, we report the assembly of prenylated heteroarenes through a cascade Minisci reaction and acid-promoted dehydration sequence. The use of potassium (3-hydroxy-3-methylbut-1-yl)trifluoroborate as a new coupling reagent allows the direct introduction of prenyl and 3-hydroxy-3-methylbutyl groups to a wide variety of electron-deficient heteroarenes. Synthetic application is also demonstrated.
authors.affiliation: School of Pharmaceutical Sciences Sun Yat-sen University Guangzhou 510006 P. R. China.
authors.forename: Dong-Hang
authors.initials: DH
authors.lastname: Tan
authors.affiliation: School of Pharmaceutical Sciences Sun Yat-sen University Guangzhou 510006 P. R. China.
authors.forename: Yao-Fu
authors.initials: YF
authors.lastname: Zeng
authors.affiliation: School of Pharmaceutical Sciences Sun Yat-sen University Guangzhou 510006 P. R. China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Liu
authors.affiliation: School of Pharmaceutical Sciences Sun Yat-sen University Guangzhou 510006 P. R. China.
authors.forename: Wen-Xin
authors.initials: WX
authors.lastname: Lv
authors.affiliation: School of Pharmaceutical Sciences Sun Yat-sen University Guangzhou 510006 P. R. China.
authors.forename: Qingjiang
authors.initials: Q
authors.lastname: Li
authors.affiliation: School of Pharmaceutical Sciences Sun Yat-sen University Guangzhou 510006 P. R. China.
authors.forename: Honggen
authors.identifier: 0000-0002-9648-6759
authors.initials: H
authors.lastname: Wang
keywords: Minisci reaction; dehydration; heteroarenes; prenylation; radical addition