title: Tandem Addition/Cyclization for Access to Isoquinolines and Isoquinolones via Catalytic Carbopalladation of Nitriles.
abstract: The first example of the palladium-catalyzed sequential nucleophilic addition followed by an intramolecular cyclization of functionalized nitriles with arylboronic acids has been achieved, providing an efficient synthetic pathway to access structurally diverse isoquinolines and isoquinolones. This methodology has also been successfully applied to the total synthesis of the topoisomerase I inhibitor CWJ-a-5 (free base).
authors.affiliation: College of Chemistry & Materials Engineering, Wenzhou University , Wenzhou, Zhejiang 325035, P. R. China.
authors.forename: Linjun
authors.initials: L
authors.lastname: Qi
authors.affiliation: College of Chemistry & Materials Engineering, Wenzhou University , Wenzhou, Zhejiang 325035, P. R. China.
authors.forename: Kun
authors.initials: K
authors.lastname: Hu
authors.affiliation: College of Chemistry & Materials Engineering, Wenzhou University , Wenzhou, Zhejiang 325035, P. R. China.
authors.forename: Shuling
authors.initials: S
authors.lastname: Yu
authors.affiliation: College of Chemistry & Materials Engineering, Wenzhou University , Wenzhou, Zhejiang 325035, P. R. China.
authors.forename: Jianghe
authors.initials: J
authors.lastname: Zhu
authors.affiliation: College of Chemistry & Materials Engineering, Wenzhou University , Wenzhou, Zhejiang 325035, P. R. China.
authors.forename: Tianxing
authors.initials: T
authors.lastname: Cheng
authors.affiliation: College of Chemistry & Materials Engineering, Wenzhou University , Wenzhou, Zhejiang 325035, P. R. China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Wang
authors.affiliation: College of Chemistry & Materials Engineering, Wenzhou University , Wenzhou, Zhejiang 325035, P. R. China.
authors.forename: Jiuxi
authors.identifier: 0000-0001-6666-9813
authors.initials: J
authors.lastname: Chen
authors.affiliation: College of Chemistry & Materials Engineering, Wenzhou University , Wenzhou, Zhejiang 325035, P. R. China.
authors.forename: Huayue
authors.identifier: 0000-0003-3431-561X
authors.initials: H
authors.lastname: Wu