title: Neural Signature of DCD: A Critical Review of MRI Neuroimaging Studies.
abstract: The most common neurodevelopmental disorders (e.g., developmental dyslexia (DD), autism, attention-deficit hyperactivity disorder (ADHD)) have been the subject of numerous neuroimaging studies, leading to certain brain regions being identified as neural correlates of these conditions, referring to a neural signature of disorders. Developmental coordination disorder (DCD), however, remains one of the least understood and studied neurodevelopmental disorders. Given the acknowledged link between motor difficulties and brain features, it is surprising that so few research studies have systematically explored the brains of children with DCD. The aim of the present review was to ascertain whether it is currently possible to identify a neural signature for DCD, based on the 14 magnetic resonance imaging neuroimaging studies that have been conducted in DCD to date. Our results indicate that several brain areas are unquestionably linked to DCD: cerebellum, basal ganglia, parietal lobe, and parts of the frontal lobe (medial orbitofrontal cortex and dorsolateral prefrontal cortex). However, research has been too sparse and studies have suffered from several limitations that constitute a serious obstacle to address the question of a well-established neural signature for DCD.
authors.affiliation: URI Octogone-Lordat (EA 4156), Université Toulouse II Jean Jaurès , Toulouse , France.
authors.forename: Maëlle
authors.initials: M
authors.lastname: Biotteau
authors.affiliation: Toulouse NeuroImaging Center, INSERM, University of Toulouse Paul Sabatier, Toulouse, France; Children's Hospital, Toulouse-Purpan University Hospital, Toulouse, France.
authors.forename: Yves
authors.initials: Y
authors.lastname: Chaix
authors.affiliation: Toulouse NeuroImaging Center, INSERM, University of Toulouse Paul Sabatier , Toulouse , France.
authors.forename: Mélody
authors.initials: M
authors.lastname: Blais
authors.affiliation: Toulouse NeuroImaging Center, INSERM, University of Toulouse Paul Sabatier , Toulouse , France.
authors.forename: Jessica
authors.initials: J
authors.lastname: Tallet
authors.affiliation: Toulouse NeuroImaging Center, INSERM, University of Toulouse Paul Sabatier , Toulouse , France.
authors.forename: Patrice
authors.initials: P
authors.lastname: Péran
authors.affiliation: Toulouse NeuroImaging Center, INSERM, University of Toulouse Paul Sabatier , Toulouse , France.
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Albaret
keywords: brain; developmental coordination disorder; neural correlates; neurodevelopmental disorder; neuroimaging