title: Self-assembly of aromatic α-amino acids into amyloid inspired nano/micro scaled architects.
abstract: In the pursuit for design of novel bio inspired materials, aromatic α-amino acids (phenylalanine, tyrosine, tryptophan and histidine) have been investigated for the generation of well-ordered self-assembled architects such as fibrils, rods, ribbons and twisted nanosheets in varying solvent systems. These nano/micro scaled architects were thoroughly characterized using FE-SEM, confocal microscopy, optical microscopy,1H NMR, FTIR, XRD and TGA. These self-assembled architects were histologically stained with Congo red and thioflavin T dyes for investigation of amyloid morphology which revealed that the deposited state of ordered assemblies exhibit specific characteristic of amyloid deposits. The self-assembly of aromatic amino acids was observed to be driven by non-covalent forces such as π-π stacking, van der Waals and electrostatic interaction.
authors.affiliation: Centre for Nanoscience and Nanotechnology, Panjab University, Sector 14, Chandigarh 160014, India.
authors.forename: Prabhjot
authors.initials: P
authors.lastname: Singh
authors.affiliation: Department of Chemistry & Centre for Advanced Studies in Chemistry, Panjab University, Sector 14, Chandigarh 160014, India.
authors.forename: Surinder K
authors.initials: SK
authors.lastname: Brar
authors.affiliation: Department of Chemistry & Centre for Advanced Studies in Chemistry, Panjab University, Sector 14, Chandigarh 160014, India.
authors.forename: Manish
authors.initials: M
authors.lastname: Bajaj
authors.affiliation: Department of Chemistry & Centre for Advanced Studies in Chemistry, Panjab University, Sector 14, Chandigarh 160014, India.
authors.forename: Nikesh
authors.initials: N
authors.lastname: Narang
authors.affiliation: Department of Chemistry, Guru Nanak Dev University, Amritsar 143040, India.
authors.forename: Venus S
authors.initials: VS
authors.lastname: Mithu
authors.affiliation: University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India.
authors.forename: Om P
authors.initials: OP
authors.lastname: Katare
authors.affiliation: Department of Applied Sciences, University Institute of Engineering and Technology (U.I.E.T.), Panjab University, Sector 25, Chandigarh 160014, India. Electronic address: nishima@pu.ac.in.
authors.forename: Nishima
authors.initials: N
authors.lastname: Wangoo
authors.affiliation: Department of Chemistry & Centre for Advanced Studies in Chemistry, Panjab University, Sector 14, Chandigarh 160014, India. Electronic address: rohitksg@pu.ac.in.
authors.forename: Rohit K
authors.initials: RK
authors.lastname: Sharma
mesh_terms: D024322:Amino Acids, Aromatic / Q000737:chemistry* / Q000378:metabolism; D000682:Amyloid / Q000737:chemistry* / Q000378:metabolism; D052160:Benzothiazoles; D003224:Congo Red / Q000737:chemistry / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D018625:Microscopy, Atomic Force; D018613:Microscopy, Confocal; D049329:Nanostructures / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013818:Thermogravimetry; D013844:Thiazoles / Q000737:chemistry / Q000378:metabolism; D014867:Water / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D024322:Amino Acids, Aromatic; D000682:Amyloid; D052160:Benzothiazoles; D013844:Thiazoles; D014867:Water; C009462:thioflavin T; D003224:Congo Red
keywords: Amyloid; Aromatic amino acids; Nanostructures; Self-assembly; Supramolecular