title: Association of serum organochlorine pesticides concentrations with reproductive hormone levels and polycystic ovary syndrome in a Chinese population.
abstract: To investigate the serum concentrations of organochlorine pesticides (OCPs) in patients with polycystic ovary syndrome (PCOS), a total of 178 women were studied. The concentrations of hexachlorocyclohexane (HCH) and dichlorodiphenyltrichloroethane (DDT) in serum were determined using Gas Chromatography Mass-Mass Spectrometer. No differences with statistical significance in the mean HCH, p,p'-DDD, p,p'-DDE concentrations were observed between the patients with PCOS and the control group. Serum p,p'-DDT (P = 0.016) and o,p'-DDT (P = 0.000) levels were significantly higher in patients with PCOS compared with the control group. The results of the association between OCPs levels and hormone levels indicated that o,p'-DDT may play a role in the pathogenesis of PCOS by affecting hormones levels. Further trials should be investigated with the findings in this study to obtain new pathogenesis of PCOS.
authors.affiliation: State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen 361102, China.
authors.forename: Zhizhun
authors.initials: Z
authors.lastname: Guo
authors.affiliation: Department of Gynaecology, The Affiliated Chenggong Hospital of Xiamen University, Xiamen 361002, China.
authors.forename: Huiling
authors.initials: H
authors.lastname: Qiu
authors.affiliation: Department of Gynaecology, The Affiliated Chenggong Hospital of Xiamen University, Xiamen 361002, China.
authors.forename: Lingling
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Gynaecology, The Affiliated Chenggong Hospital of Xiamen University, Xiamen 361002, China.
authors.forename: Lijun
authors.initials: L
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen 361102, China; Key Laboratory of Ministry of Education for Subtropical Wetland Ecosystem Research, Xiamen University, Xiamen 361102, China.
authors.forename: Chonggang
authors.initials: C
authors.lastname: Wang
authors.affiliation: Key Laboratory of Ministry of Education for Subtropical Wetland Ecosystem Research, Xiamen University, Xiamen 361102, China. Electronic address: mengchen@xmu.edu.cn.
authors.forename: Meng
authors.initials: M
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen 361102, China; Key Laboratory of Ministry of Education for Subtropical Wetland Ecosystem Research, Xiamen University, Xiamen 361102, China. Electronic address: zuozhenghong@xmu.edu.cn.
authors.forename: Zhenghong
authors.initials: Z
authors.lastname: Zuo
mesh_terms: D000328:Adult; D044466:Asian People; D002681:China; D003634:DDT / Q000097:blood*; D003633:Dichlorodiphenyl Dichloroethylene / Q000097:blood*; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000097:blood*; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D001556:Hexachlorocyclohexane / Q000097:blood*; D006728:Hormones / Q000097:blood; D006801:Humans; D010575:Pesticides / Q000097:blood*; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D055815:Young Adult
chemical_list: D004785:Environmental Pollutants; D006728:Hormones; D010575:Pesticides; D003633:Dichlorodiphenyl Dichloroethylene; D001556:Hexachlorocyclohexane; D003634:DDT
keywords: Endocrine disrupting; Organochlorine pesticides; Polycystic ovary syndrome; Serum