title: Wide Morphologic Variability of Chromoblastomycosis in the Western Hemisphere.
abstract: Chromomycosis is an uncommon fungal disease seen in tropical and subtropical regions of the world. The disorder is most likely the result of traumatic percutaneous inoculation of one of several etiologic dematiaceous fungi. Causative organisms have been associated with dead wood, soil, and plants. Chromomycosis may present clinically in a wide variety of manners. We illustrate the characteristic morphologic appearances of mycosis as it was encountered in both Panama and Texas, including verrucous papules and nodules, scaly plaques, exophytic or ulcerative tumor-like masses, and cicatricial plaques of both small and large dimension. As is typical of this disease, all lesions in this series were located on the extremities, and all patients had frequent and intimate exposure to vegetation in hot, humid environments. Chromomycosis characteristically runs an indolent course and is rarely fatal. The patients described herein had experienced cutaneous lesions for many months to several decades prior to diagnosis. This mycosis is often difficult to treat. Successful therapy may involve one or more oral antifungal drugs (such as itraconazole and terbinafine) and/or use of physically ablative modalities (such as laser, photodynamic therapy, and cryosurgery).
authors.affiliation: University of Texas Health Science Center School of Medicine, San Antonio, TX.
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Mugleston
authors.affiliation: Division of Dermatology and Cutaneous Surgery and the Department of Family Medicine, University of Texas Health Science Center School of Medicine, San Antonio, TX; usatine@uthscsa.edu.
authors.forename: Richard P
authors.initials: RP
authors.lastname: Usatine
authors.affiliation: Department of Dermatology, Baylor College of Medicine, Houston, TX.
authors.forename: Ted
authors.initials: T
authors.lastname: Rosen
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D002862:Chromoblastomycosis / Q000473:pathology* / Q000628:therapy*; D003452:Cryosurgery; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D053685:Laser Therapy; D009281:Naphthalenes / Q000627:therapeutic use; D010176:Panama; D010778:Photochemotherapy; D000077291:Terbinafine; D013781:Texas
chemical_list: D000935:Antifungal Agents; D009281:Naphthalenes; D017964:Itraconazole; D000077291:Terbinafine