title: Circulating thyroid stimulating hormone receptor messenger RNA and differentiated thyroid cancer: A diagnostic meta-analysis.
abstract: Thyroid stimulating hormone receptor messenger RNA (TSHR-mRNA) is over-expressed in thyroid cancer patients, which indicates that TSHR-mRNA is a potential biomarker of thyroid cancer. However, system evaluation for TSHR-mRNA as a diagnostic biomarker of thyroid cancer is deficient. The performance of TSHR-mRNA for thyroid cancer diagnosis was evaluated in this study. Three common international databases as well as a Chinese database were applied for literature researching. Quality assessment of the included literatures was conducted by the QUADAS-2 tool. Totally, 1027 patients from nine studies eligible for the meta-analysis were included in this study. Global sensitivity and specificity for the positivity of TSHR-mRNA in the thyroid cancer diagnosis is 72% and 82%. The value of AUC for this test performance was 0.84. Our meta-analysis suggests that TSHR-mRNA might be a potential biomarker to complete present diagnostic methods for early and precision diagnosis of thyroid cancer. Notably, this findings need validation thorough large-scale clinical studies.
authors.affiliation: Institute of Biomedical Sciences, Minhang Hospital, Fudan University, Shanghai, P.R. China.|School of Public Health Taishan Medical University, Shandong, P.R. China.
authors.forename: Zhen-Zhen
authors.initials: ZZ
authors.lastname: Zhang
authors.affiliation: School of Public Health Taishan Medical University, Shandong, P.R. China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Chen
authors.affiliation: Institute of Biomedical Sciences, Minhang Hospital, Fudan University, Shanghai, P.R. China.
authors.forename: Chao-Yue
authors.initials: CY
authors.lastname: Kong
authors.affiliation: Institute of Biomedical Sciences, Minhang Hospital, Fudan University, Shanghai, P.R. China.
authors.forename: Zhan-Ming
authors.initials: ZM
authors.lastname: Li
authors.affiliation: Institute of Biomedical Sciences, Minhang Hospital, Fudan University, Shanghai, P.R. China.
authors.forename: Li-Shun
authors.initials: LS
authors.lastname: Wang
mesh_terms: D019540:Area Under Curve; D014408:Biomarkers, Tumor / Q000097:blood / Q000235:genetics*; D000073888:Cell-Free Nucleic Acids / Q000097:blood / Q000235:genetics*; D016009:Chi-Square Distribution; D055088:Early Detection of Cancer / Q000379:methods*; D006801:Humans; D011237:Predictive Value of Tests; D011379:Prognosis; D012333:RNA, Messenger / Q000097:blood / Q000235:genetics*; D012334:RNA, Neoplasm / Q000097:blood / Q000235:genetics*; D012372:ROC Curve; D011988:Receptors, Thyroid Hormone / Q000097:blood / Q000235:genetics*; D015203:Reproducibility of Results; D013964:Thyroid Neoplasms / Q000097:blood / Q000235:genetics* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D000073888:Cell-Free Nucleic Acids; D012333:RNA, Messenger; D012334:RNA, Neoplasm; D011988:Receptors, Thyroid Hormone
keywords: diagnostic meta-analysis; thyroid cancer; thyroid stimulating hormone receptor