title: Cognitive fatigue in patients with myasthenia gravis.
abstract: Cognitive fatigue has frequently been reported in myasthenia gravis (MG). However, objective assessment of cognitive fatigability has never been evaluated.
  
  
  
  Thirty-three MG patients with stable generalized disease and 17 healthy controls underwent a test battery including repeated testing of attention and concentration (d2-R) and Paced Auditory Serial Addition Test. Fatigability was based on calculation of linear trend (LT) reflecting dynamic performance within subsequent constant time intervals. Additionally, fatigue questionnaires were used.
  
  
  
  MG patients showed a negative LT in second d2-R testing, indicating cognitive fatigability. This finding significantly differed from stable cognitive performance in controls (P < 0.05). Results of Paced Auditory Serial Addition Test testing did not differ between groups. Self-assessed fatigue was significantly higher in MG patients compared with controls (P < 0.001), but did not correlate with LT.
  
  
  
  LT quantifies cognitive fatigability as an objective measurement of performance decline in MG patients. Self-assessed cognitive fatigue is not correlated with objective findings. Muscle Nerve 56: 449-457, 2017.
authors.affiliation: Department of Neurology, Martin-Luther-University Halle, Ernst-Grube-Strasse 40, 06097, Halle/Saale, Germany.
authors.forename: Berit
authors.initials: B
authors.lastname: Jordan
authors.affiliation: Institute of Psychology, Martin-Luther-University Halle, Halle/Saale, Germany.
authors.forename: Tabea L K
authors.initials: TLK
authors.lastname: Schweden
authors.affiliation: Department of Neurology, Martin-Luther-University Halle, Ernst-Grube-Strasse 40, 06097, Halle/Saale, Germany.
authors.forename: Theresa
authors.initials: T
authors.lastname: Mehl
authors.affiliation: Institute of Psychology, Martin-Luther-University Halle, Halle/Saale, Germany.
authors.forename: Uwe
authors.initials: U
authors.lastname: Menge
authors.affiliation: Department of Neurology, Martin-Luther-University Halle, Ernst-Grube-Strasse 40, 06097, Halle/Saale, Germany.
authors.forename: Stephan
authors.initials: S
authors.lastname: Zierz
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003071:Cognition / Q000502:physiology; D003072:Cognition Disorders / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology*; D005221:Fatigue / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018763:Muscle Fatigue / Q000502:physiology; D009157:Myasthenia Gravis / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology*; D009483:Neuropsychological Tests; D055815:Young Adult
keywords: cognition; d2-R testing; fatigability; fatigue; linear trend; myasthenia gravis