title: Metabolic enzymes: key modulators of functionality in cancer stem-like cells.
abstract: Cancer Stem-like Cells (CSCs) are a subpopulation of cancer cells with self-renewal capacity and are important for the initiation, progression and recurrence of cancer diseases. The metabolic profile of CSCs is consistent with their stem-like properties. Studies have indicated that enzymes, the main regulators of cellular metabolism, dictate functionalities of CSCs in both catalysis-dependent and catalysis-independent manners. This paper reviews diverse studies of metabolic enzymes, and describes the effects of these enzymes on metabolic adaptation, gene transcription and signal transduction, in CSCs.
authors.affiliation: Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Bo-Wen
authors.initials: BW
authors.lastname: Dong
authors.affiliation: Department of Clinical Laboratory Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Guang-Ming
authors.initials: GM
authors.lastname: Qin
authors.affiliation: School of Basic Medical Sciences, Zhejiang University, Hangzhou, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Jian-Shan
authors.initials: JS
authors.lastname: Mao
mesh_terms: D000818:Animals; D006801:Humans; D014411:Neoplastic Stem Cells / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
keywords: cancer stem-like cells; enzymes; mechanism; metabolism; stemness