title: Machine learning based detection of age-related macular degeneration (AMD) and diabetic macular edema (DME) from optical coherence tomography (OCT) images.
abstract: Non-lethal macular diseases greatly impact patients' life quality, and will cause vision loss at the late stages. Visual inspection of the optical coherence tomography (OCT) images by the experienced clinicians is the main diagnosis technique. We proposed a computer-aided diagnosis (CAD) model to discriminate age-related macular degeneration (AMD), diabetic macular edema (DME) and healthy macula. The linear configuration pattern (LCP) based features of the OCT images were screened by the Correlation-based Feature Subset (CFS) selection algorithm. And the best model based on the sequential minimal optimization (SMO) algorithm achieved 99.3% in the overall accuracy for the three classes of samples.
authors.affiliation: Sino-Dutch Biomedical and Information Engineering School, Northeastern University, Shenyang, Liaoning 110169, China; Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong 518055, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Sino-Dutch Biomedical and Information Engineering School, Northeastern University, Shenyang, Liaoning 110169, China; College of Electronics and Information Engineering, Xi'an Siyuan University, Xi'an 710038, China; zhangyn@bmie.neu.edu.cn.
authors.forename: Yaonan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Sino-Dutch Biomedical and Information Engineering School, Northeastern University, Shenyang, Liaoning 110169, China; Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong 518055, China.
authors.forename: Zhaomin
authors.initials: Z
authors.lastname: Yao
authors.affiliation: College of Computer Science and Technology, Jilin University, Changchun, Jilin 130012, China; Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education, Jilin University, Changchun, Jilin 130012, China.
authors.forename: Ruixue
authors.initials: R
authors.lastname: Zhao
authors.affiliation: College of Computer Science and Technology, Jilin University, Changchun, Jilin 130012, China; Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education, Jilin University, Changchun, Jilin 130012, China; FengfengZhou@gmail.com; ffzhou@jlu.edu.cn; http://www.healthinformaticslab.org/ffzhou/.
authors.forename: Fengfeng
authors.initials: F
authors.lastname: Zhou
keywords: (100.0100) Image processing; (100.2960) Image analysis; (100.5010) Pattern recognition; (170.4470) Ophthalmology; (170.4500) Optical coherence tomography