title: Perceived Cognition after Percutaneous Coronary Intervention: Association with Quality of Life, Mood and Fatigue in the THORESCI Study.
abstract: Percutaneous coronary intervention (PCI) is a common invasive procedure for the treatment of coronary artery diseases. Long-term cognitive functioning after PCI and its association with health-related quality of life (HRQL) and psychological factors is relatively unknown. The aim of this study is to examine whether perceived cognitive functioning during the year after PCI is associated with HRQL over this time period, and whether mood, fatigue, and age are associated with changes in perceived cognition and HRQL.
  
  
  
  Patients undergoing PCI (n = 384, 79% male, mean age = 63, SD = 10) were recruited in the observational Tilburg Health Outcome Registry of Emotional Stress after Coronary Intervention (THORESCI) cohort study. Perceived concentration and attention problems, HRQL, mood, and fatigue were assessed at baseline, at 1-month and 12-month follow-up.
  
  
  
  General linear mixed modeling analysis showed that across time, between- and within-subject differences in perceived concentration problems were associated with a reduced HRQL in all domains independent of clinical and demographic covariates. Only a part of this association could be explained by negative mood, fatigue, and older age. Similar findings were found for between-subject differences in perceived attention problems.
  
  
  
  Between-subject differences and within-subject changes in perceived cognition in PCI patients were strongly associated with HRQL across time, such that poorer perceived cognition was associated with poorer HRQL, independent of demographic and clinical variables. Most of the associations were also independent of mood and fatigue. The results should increase the awareness of clinicians for the role of cognition in the cardiac rehabilitation and recovery post-PCI.
authors.affiliation: Department of Medical and Clinical Psychology, CoRPS-Centre of Research on Psychological and Somatic Diseases, Tilburg University, Tilburg, the Netherlands.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Duijndam
authors.affiliation: Department of Medical and Clinical Psychology, CoRPS-Centre of Research on Psychological and Somatic Diseases, Tilburg University, Tilburg, the Netherlands.
authors.forename: Johan
authors.initials: J
authors.lastname: Denollet
authors.affiliation: Department of Medical and Clinical Psychology, CoRPS-Centre of Research on Psychological and Somatic Diseases, Tilburg University, Tilburg, the Netherlands.
authors.forename: Ivan
authors.initials: I
authors.lastname: Nyklíček
authors.affiliation: Department of Medical and Clinical Psychology, CoRPS-Centre of Research on Psychological and Somatic Diseases, Tilburg University, Tilburg, the Netherlands. h.m.kupper@tilburguniversity.edu.
authors.forename: Nina
authors.identifier: 0000-0001-8721-5239
authors.initials: N
authors.lastname: Kupper
mesh_terms: D000339:Affect; D000368:Aged; D003071:Cognition; D015331:Cohort Studies; D003324:Coronary Artery Disease / Q000628:therapy; D005221:Fatigue / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008603:Mental Health; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D010465:Perception; D062645:Percutaneous Coronary Intervention; D011788:Quality of Life; D012042:Registries; D013315:Stress, Psychological
keywords: Age; Cognition; Fatigue; Mood; Percutaneous coronary intervention; Quality of life