title: Neurologic Complications after Allogeneic Hematopoietic Stem Cell Transplantation.
abstract: Neurologic complications after hematopoietic stem cell transplantation are frequently life-threatening, and their clinical management can be highly challenging. A wide spectrum of causative factors-including drug-related toxicities; infections sustained by virus, bacteria, or invasive molds; metabolic encephalopathy; cerebrovascular disorders; immune-mediated disorders; and disease recurrence-may lead to potentially lethal complications. Moreover, given that some neurologic complications are not uncommonly diagnosed post mortem, their overall incidence is likely to be underestimated. Their prompt recognition and timely treatment are of paramount importance to reduce the risk for transplantation-related death.
authors.affiliation: Department of Oncology, AOU Città della Salute e della Scienza di Torino, Presidio Molinette, Torino, Italy; Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.
authors.forename: Enrico
authors.initials: E
authors.lastname: Maffini
authors.affiliation: Department of Oncology, AOU Città della Salute e della Scienza di Torino, Presidio Molinette, Torino, Italy; Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.
authors.forename: Moreno
authors.initials: M
authors.lastname: Festuccia
authors.affiliation: Department of Oncology, AOU Città della Salute e della Scienza di Torino, Presidio Molinette, Torino, Italy; Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.
authors.forename: Lucia
authors.initials: L
authors.lastname: Brunello
authors.affiliation: Department of Oncology, AOU Città della Salute e della Scienza di Torino, Presidio Molinette, Torino, Italy; Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Boccadoro
authors.affiliation: Department of Oncology, AOU Città della Salute e della Scienza di Torino, Presidio Molinette, Torino, Italy; Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.
authors.forename: Luisa
authors.initials: L
authors.lastname: Giaccone
authors.affiliation: Department of Oncology, AOU Città della Salute e della Scienza di Torino, Presidio Molinette, Torino, Italy; Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy. Electronic address: benedetto.bruno@unito.it.
authors.forename: Benedetto
authors.initials: B
authors.lastname: Bruno
mesh_terms: D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects* / Q000401:mortality; D006801:Humans; D015994:Incidence; D009422:Nervous System Diseases / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D014184:Transplantation, Homologous
keywords: Central nervous system; Cerebral aspergillosis; Cyclosporine; Hematopoietic stem cell transplantation; Neurological complications; Viral encephalitis