title: Spongian-16-one Diterpenes and Their Anatomical Distribution in the Australian Nudibranch Goniobranchus collingwoodi.
abstract: Six new (1-6) spongian-16-one analogues have been characterized from the Australian nudibranch species Goniobranchus collingwoodi, along with four known spongian-16-one derivatives. The structures and relative configuration were suggested by spectroscopic analyses informed by molecular modeling. Dissection of animal tissue revealed that the mantle and viscera differ in their terpene composition. Whole body extracts were not toxic to brine shrimp (Artemia sp.), but were unpalatable to palaemon shrimp (Palaemon serenus) at a concentration found within the nudibranch. Individual terpenes were not cytotoxic to human lung (NCIH-460), colorectal (SW620), and liver (HepG2) cancer cells.
authors.affiliation: School of Chemistry and Molecular Biosciences, ‡School of Biological Sciences, and §Institute for Molecular Bioscience, The University of Queensland , Brisbane, QLD 4072, Australia.
authors.forename: Louise C
authors.initials: LC
authors.lastname: Forster
authors.affiliation: School of Chemistry and Molecular Biosciences, ‡School of Biological Sciences, and §Institute for Molecular Bioscience, The University of Queensland , Brisbane, QLD 4072, Australia.
authors.forename: Anne E
authors.initials: AE
authors.lastname: Winters
authors.affiliation: School of Chemistry and Molecular Biosciences, ‡School of Biological Sciences, and §Institute for Molecular Bioscience, The University of Queensland , Brisbane, QLD 4072, Australia.
authors.forename: Karen L
authors.initials: KL
authors.lastname: Cheney
authors.affiliation: School of Chemistry and Molecular Biosciences, ‡School of Biological Sciences, and §Institute for Molecular Bioscience, The University of Queensland , Brisbane, QLD 4072, Australia.
authors.forename: Pradeep
authors.initials: P
authors.lastname: Dewapriya
authors.affiliation: School of Chemistry and Molecular Biosciences, ‡School of Biological Sciences, and §Institute for Molecular Bioscience, The University of Queensland , Brisbane, QLD 4072, Australia.
authors.forename: Robert J
authors.identifier: 0000-0002-8341-7754
authors.initials: RJ
authors.lastname: Capon
authors.affiliation: School of Chemistry and Molecular Biosciences, ‡School of Biological Sciences, and §Institute for Molecular Bioscience, The University of Queensland , Brisbane, QLD 4072, Australia.
authors.forename: Mary J
authors.identifier: 0000-0001-8670-1075
authors.initials: MJ
authors.lastname: Garson
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001315:Australia; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D049851:Gastropoda / Q000737:chemistry*; D056945:Hep G2 Cells; D006801:Humans; D015394:Molecular Structure
chemical_list: D000970:Antineoplastic Agents; D004224:Diterpenes