title: Isoflurane Induces Transient Impairment of Retention of Spatial Working Memory in Rats.
abstract: Postoperative cognitive dysfunction (POCD) occurs in nearly one-third of patients after non-cardiac surgery. Many animal behavior studies have investigated the effect of general anesthesia on cognitive function. However, there have been no studies examining the effects on working memory specifically, with a focus on the retention of working memory. We demonstrate here that isoflurane anesthesia induces deficits in the retention of spatial working memory in rats, as revealed by an increase in isoflurane- induced across-phase errors in the delayed spatial win-shift (SWSh) task with a 30-min delay in an 8-arm radial arm maze on post-anesthesia days (PADs) 1,2,4, and 10. A post-hoc analysis revealed a significant increase in across-phase errors on PAD 1 and recovery on PAD 10 in the isoflurane group. In contrast, within-phase errors independent of the retention of working memory were unaffected by isoflurane. These results demonstrate that isoflurane anesthesia transiently impairs the retention of spatial working memory in rats.
authors.affiliation: Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan. masaaki-koc@umin.net.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Tanino
authors.forename: Motomu
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Sasaki
authors.forename: Ken
authors.initials: K
authors.lastname: Takata
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Takeda
authors.forename: Satoshi
authors.initials: S
authors.lastname: Mizobuchi
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Morita
authors.forename: Taku
authors.initials: T
authors.lastname: Nagai
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Morimatsu
mesh_terms: D018685:Anesthetics, Inhalation / Q000009:adverse effects*; D000818:Animals; D007530:Isoflurane / Q000009:adverse effects*; D008297:Male; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D065853:Spatial Learning / Q000187:drug effects / Q000502:physiology; D065852:Spatial Memory / Q000187:drug effects*; D013997:Time Factors
chemical_list: D018685:Anesthetics, Inhalation; D007530:Isoflurane