title: Personalized Nanoparticles for Cancer Therapy: A Call for Greater Precision.
abstract: Nanotechnology has brought about the advent of personalized medicine in the era of targeted therapeutic strategies for cancer therapy. The ability to exploit tumor features for therapeutic gain has made it possible to manufacture more effective nanomedicines for cancer treatment. However, known obstacles, including the inability to overcome pathophysiological barriers of tumors, have impeded disease management. In spite of this, recent efforts have been made to develop more functionalized nanosystems that utilize the active-targeting approach. This article reviews the FDA-approved cancer drug delivery systems in the general framework of personalized nanomedicine. We discuss the latest efforts in the development of functionalized nano-systems, and summarize relevant ongoing preclinical and clinical trials.
authors.affiliation: Massachusetts College of Pharmacy and Health Sciences, 19 Foster St. Worcester, MA 01608, United States.
authors.forename: Nare
authors.initials: N
authors.lastname: Sahakyan
authors.affiliation: Massachusetts College of Pharmacy and Health Sciences, 19 Foster St. Worcester, MA 01608, United States.
authors.forename: Amir
authors.initials: A
authors.lastname: Haddad
authors.affiliation: Massachusetts College of Pharmacy and Health Sciences, 19 Foster St. Worcester, MA 01608, United States.
authors.forename: Shye
authors.initials: S
authors.lastname: Richardson
authors.affiliation: Massachusetts College of Pharmacy and Health Sciences, 19 Foster St. Worcester, MA 01608, United States.
authors.forename: Valery
authors.initials: V
authors.lastname: Forcha-Etieundem
authors.affiliation: Massachusetts College of Pharmacy and Health Sciences, 19 Foster St. Worcester, MA 01608, United States.
authors.forename: Lee
authors.initials: L
authors.lastname: Christopher
authors.affiliation: Massachusetts College of Pharmacy and Health Sciences, 19 Foster St. Worcester, MA 01608, United States.
authors.forename: Hanan
authors.initials: H
authors.lastname: Alharbi
authors.affiliation: Pharmaceutical Sciences, Massachusetts College of Pharmacy and Health Sciences, Department of Pharmaceutical Sciences, 19 Foster St. Worcester, MA 01608, United States.
authors.forename: Robert
authors.initials: R
authors.lastname: Campbell
mesh_terms: D006801:Humans; D053758:Nanoparticles / Q000627:therapeutic use*; D036103:Nanotechnology; D009369:Neoplasms / Q000188:drug therapy*; D057285:Precision Medicine
keywords: Personalized medicine; cancer therapy; drug delivery; nanoparticles; nanotechnology; tumor-targeted nanomedicines