title: The comparison of treatments with and without azithromycin in irritable bowel syndrome with diarrhea-predominant in gastrointestinal Clinic of Al-Zahra Hospital, Isfahan, Iran.
abstract: BACKGROUND
  Irritable bowel syndrome (IBS) is a common gastrointestinal disorder. Recent studies suggest the importance of gut flora in the pathophysiology of it. Therefore, antibiotics have demonstrated a substantial benefit to reduce gut flora. Having few side effects, and applying one-dose per day, we studied the effect of azithromycin to treat IBS.
  
  
  METHODS
  One hundred and twenty-six patients enrolled a randomized, double-blind, placebo-controlled study. The treatment group received azithromycin in addition to common treatment. Patients were followed for 12 weeks. Patients completed daily diaries documenting their symptoms.
  
  
  RESULTS
  One hundred and thirteen patients completed the study. The onset of relief occurred significantly sooner, and duration of relief was significantly longer in azithromycin group. Movement, abdominal pain, bloating, and gas were significantly better in azithromycin group. Monthly results showed superior relief in bloating, gas, overall symptom, and overall bloating during 3 months. Significantly more patients in azithromycin group felt relief in bloating and gas and had greater consistency relief in almost all weeks.
  
  
  CONCLUSIONS
  In our study, azithromycin significantly relieved most symptoms, such as abdominal pain, bloating, and gas. Overall symptom and overall bloating were relieved significantly in more patients in the intervention group in all weeks.
authors.affiliation: Department of Infectious Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Mohamadreza
authors.initials: M
authors.lastname: Yazdani
authors.affiliation: Department of Infectious Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Amirhossein
authors.initials: A
authors.lastname: Aramesh
authors.affiliation: Department of Internal Medicine, School of Medicine, Islamic University, Najafabad Branch, Isfahan, Iran.
authors.forename: Rahmatollah
authors.initials: R
authors.lastname: Rafiei
authors.affiliation: Integrative Functional Gastroenterology Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Hamed
authors.initials: H
authors.lastname: Daghaghzadeh
authors.affiliation: Integrative Functional Gastroenterology Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Peyman
authors.initials: P
authors.lastname: Adibi
keywords: Azithromycin; diarrhea-predominant; gastrointestinal; irritable bowel syndrome