title: Lower body mass index is associated with orthostatic hypotension in Parkinson's disease.
abstract: BACKGROUND
  Lower body mass index (BMI) is associated with orthostatic hypotension (OH) in the general population, especially in the elderly; however, no studies have addressed this issue in Parkinson's disease (PD).
  
  
  METHODS
  We investigated the results of the head-up tilt test and BMI of patients with PD, and evaluated whether BMI is related to orthostatic systolic blood pressure (SBP) change during the head-up tilt test. PD patients were divided into male and female groups, and further divided into middle-aged (age<65years) and elderly (age≥65years) subgroups in each sex.
  
  
  RESULTS
  OH was observed in 13 of 64 male and 12 of 75 female patients with PD. BMI was lower in patients with OH than in those without, in both men and women. In the elderly group, a significant correlation between BMI and orthostatic SBP change was found (men, r=0.47, p=0.006; women, r=0.43, p=0.005), and a BMI below mean-0.5 standard deviation increased OH odds (men: BMI<20.5; odds ratio, 6.79; 95% CI, 1.06-43.36; women: BMI<18.5; odds ratio, 5.11; 95% CI, 1.05-24.96).
  
  
  CONCLUSIONS
  Lower BMI is a predisposing factor of OH in elderly patients with PD.
authors.affiliation: Department of Neurology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan; Department of Laboratory Medicine, Nagoya University Hospital, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. Electronic address: tomohiko@med.nagoya-u.ac.jp.
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Nakamura
authors.affiliation: Department of Neurology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Suzuki
authors.affiliation: Department of Neurology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.
authors.forename: Miki
authors.initials: M
authors.lastname: Ueda
authors.affiliation: Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, 1-1-20 Daiko-Minami, Higashi-ku, Nagoya 461-8673, Japan.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Hirayama
authors.affiliation: Department of Neurology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. Electronic address: ka2no@med.nagoya-u.ac.jp.
authors.forename: Masahisa
authors.initials: M
authors.lastname: Katsuno
mesh_terms: D000367:Age Factors; D000368:Aged; D015992:Body Mass Index; D001835:Body Weight; D015331:Cohort Studies; D019468:Disease Management; D005260:Female; D006339:Heart Rate; D006801:Humans; D007024:Hypotension, Orthostatic / Q000175:diagnosis / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications*; D011187:Posture; D018667:Tilt-Table Test
keywords: Autonomic dysfunction; Body mass index; Orthostatic hypotension; Parkinson's disease; Sympathetic nervous system