title: OXTR polymorphism in depression and completed suicide-A study on a large population sample.
abstract: In the light of contradictory results concerning OXTR polymorphism rs53576 and depression, we decided to verify the potential association between the two on 1) a large, ethnically homogenous sample of 1185 individuals who completed the Beck Depression Inventory (BDI), as well as on 2) a sample of 763 suicide victims. In the population sample, AA males showed significantly lower BDI scores (p=0.005, pcor=0.030). Exploratory analyses suggested that this effect was limited to a subgroup within 0-9 BDI score range (p=0.0007, U-Mann Whitney test), whereas no main effect on depressive symptoms (BDI>9) was found. In the suicide sample no association with rs53576 genotype was present. Exploratory analyses in suicides revealed higher blood alcohol concentration (BAC) among AA than GG/GA males (p=0.014, U-Mann Whitney test). Our results show that the OXTR rs53576 variant modulates the mood in male individuals and may positively correlate with alcohol intake among male suicides, but is not associated with suicide or depression. The study adds to the growing knowledge on rs53576 genotype characteristics.
authors.affiliation: Department of Medical Genetics, Medical University of Warsaw, ul. Pawińskiego 3c, 02-106 Warsaw, Poland.
authors.forename: Krystyna
authors.initials: K
authors.lastname: Wasilewska
authors.affiliation: Department of Forensic Medicine, Medical University of Warsaw, ul. Oczki 1, 02-007 Warsaw, Poland; Department of Clinical Nursing, Medical University of Warsaw, ul. Erazma Ciołka 27, 01-445 Warsaw, Poland.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Pawlak
authors.affiliation: Department of Forensic Medicine, Medical University of Warsaw, ul. Oczki 1, 02-007 Warsaw, Poland.
authors.forename: Grażyna
authors.initials: G
authors.lastname: Kostrzewa
authors.affiliation: Department of General Biology and Parasitology, Medical University of Warsaw, ul. Chałubińskiego 5, 02-004 Warsaw, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Sobczyk-Kopcioł
authors.affiliation: Department of Forensic Medicine, Medical University of Warsaw, ul. Oczki 1, 02-007 Warsaw, Poland.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Kaczorowska
authors.affiliation: Department of Medical Genetics, Medical University of Warsaw, ul. Pawińskiego 3c, 02-106 Warsaw, Poland.
authors.forename: Jarosław
authors.initials: J
authors.lastname: Badowski
authors.affiliation: Department of Forensic Medicine, Medical University of Warsaw, ul. Oczki 1, 02-007 Warsaw, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Brzozowska
authors.affiliation: Department of Epidemiology, Cardiovascular Disease Prevention and Health Promotion, Institute of Cardiology, ul. Niemodlińska 33, 04-635 Warsaw, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Drygas
authors.affiliation: Department of Epidemiology, Cardiovascular Disease Prevention and Health Promotion, Institute of Cardiology, ul. Niemodlińska 33, 04-635 Warsaw, Poland.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Piwoński
authors.affiliation: Department of Social and Preventive Medicine, Medical University of Lodz, ul. Żeligowskiego 7/9, 90-752 Łódź, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Bielecki
authors.affiliation: Department of Medical Genetics, Medical University of Warsaw, ul. Pawińskiego 3c, 02-106 Warsaw, Poland. Electronic address: rploski@wp.pl.
authors.forename: Rafał
authors.initials: R
authors.lastname: Płoski
mesh_terms: D000328:Adult; D000339:Affect / Q000502:physiology; D000428:Alcohol Drinking / Q000235:genetics; D003866:Depressive Disorder / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D018045:Receptors, Oxytocin / Q000235:genetics*; D012737:Sex Factors; D013405:Suicide
chemical_list: D018045:Receptors, Oxytocin
keywords: Alcohol; Beck depression inventory; Depression; OXTR; Suicide; rs53576