title: Bioactive glasses as delivery systems for antimicrobial agents.
abstract: Most biomaterial-associated infections are caused by opportunistic pathogens and bacteria that are regularly found within the microflora of the implant site. In addition, a biomaterial implant or device remains at risk of infection by hematogenous spread of bacteria disseminated from infections elsewhere in the body or from infected peri-implant tissue in revision surgery. The resulting infections are frequently accompanied by patient morbidity and discomfort and can lead to surgical replacement of the implant after lengthy, unsuccessful attempts to mitigate infections with antibiotic treatments. Therefore, extensive study is aiming to find new infection-resistant antimicrobial biomaterials and coatings for implants and devices to effectively reduce the incidence of biomaterial-associated infections. An overview of the in vitro and in vivo antimicrobial efficacies of the numerous biomaterials currently available is beyond the scope of this review. Herein, we provide a comprehensive review of bioactive glasses as biomaterial delivery systems for antimicrobial agents.
authors.affiliation: Interdisciplinary Materials Group-IESIING-UCASAL, INTECIN UBA-CONICET, A4400EDD, Salta, Argentina.
authors.forename: J
authors.initials: J
authors.lastname: Rivadeneira
authors.affiliation: Interdisciplinary Materials Group-IESIING-UCASAL, INTECIN UBA-CONICET, A4400EDD, Salta, Argentina.
authors.forename: A
authors.initials: A
authors.lastname: Gorustovich
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D000890:Anti-Infective Agents; D001672:Biocompatible Materials / Q000009:adverse effects* / Q000737:chemistry; D006801:Humans; D008670:Metals / Q000737:chemistry / Q000627:therapeutic use; D019736:Prostheses and Implants / Q000382:microbiology*; D016459:Prosthesis-Related Infections / Q000188:drug therapy / Q000517:prevention & control*; D012822:Silicon Dioxide / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D001672:Biocompatible Materials; D008670:Metals; D012822:Silicon Dioxide
keywords: antibacterial activity; antimicrobial agents; bioactive glasses; biomaterials; delivery systems; infection