title: AllergoOncology - the impact of allergy in oncology: EAACI position paper.
abstract: Th2 immunity and allergic immune surveillance play critical roles in host responses to pathogens, parasites and allergens. Numerous studies have reported significant links between Th2 responses and cancer, including insights into the functions of IgE antibodies and associated effector cells in both antitumour immune surveillance and therapy. The interdisciplinary field of AllergoOncology was given Task Force status by the European Academy of Allergy and Clinical Immunology in 2014. Affiliated expert groups focus on the interface between allergic responses and cancer, applied to immune surveillance, immunomodulation and the functions of IgE-mediated immune responses against cancer, to derive novel insights into more effective treatments. Coincident with rapid expansion in clinical application of cancer immunotherapies, here we review the current state-of-the-art and future translational opportunities, as well as challenges in this relatively new field. Recent developments include improved understanding of Th2 antibodies, intratumoral innate allergy effector cells and mediators, IgE-mediated tumour antigen cross-presentation by dendritic cells, as well as immunotherapeutic strategies such as vaccines and recombinant antibodies, and finally, the management of allergy in daily clinical oncology. Shedding light on the crosstalk between allergic response and cancer is paving the way for new avenues of treatment.
authors.affiliation: The Interuniversity Messerli Research Institute, University of Veterinary Medicine Vienna, Medical University of Vienna, Vienna, Austria.|Institute of Pathophysiology & Allergy Research, Center of Pathophysiology, Infectiology & Immunology, Medical University Vienna, Vienna, Austria.
authors.forename: E
authors.identifier: http://orcid.org/0000-0003-4019-5765
authors.initials: E
authors.lastname: Jensen-Jarolim
authors.affiliation: Division of Genetics & Molecular Medicine, Faculty of Life Sciences and Medicine, St. John's Institute of Dermatology, King's College London, London, UK.|Division of Cancer Studies, Faculty of Life Sciences & Medicine, King's College London, Guy's Hospital, London, UK.
authors.forename: H J
authors.initials: HJ
authors.lastname: Bax
authors.affiliation: The Interuniversity Messerli Research Institute, University of Veterinary Medicine Vienna, Medical University of Vienna, Vienna, Austria.
authors.forename: R
authors.initials: R
authors.lastname: Bianchini
authors.affiliation: LIRIC-Unité Mixte de Recherche 995 INSERM, Université de Lille 2, CHRU de Lille, Lille, France.
authors.forename: M
authors.initials: M
authors.lastname: Capron
authors.affiliation: Division of Asthma, Allergy and Lung Biology, Medical Research Council and Asthma UK Centre in Allergic Mechanisms in Asthma, King's College London, London, UK.
authors.forename: C
authors.initials: C
authors.lastname: Corrigan
authors.affiliation: Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: M
authors.initials: M
authors.lastname: Castells
authors.affiliation: INSERM, CHU Lille, European Genomic Institute of Diabetes, Institut Pasteur de Lille, U1011 - récepteurs nucléaires, maladies cardiovasculaires et diabète, Université de Lille, Lille, France.
authors.forename: D
authors.initials: D
authors.lastname: Dombrowicz
authors.affiliation: Division of Surgical Oncology, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
authors.forename: T R
authors.initials: TR
authors.lastname: Daniels-Wells
authors.affiliation: The Interuniversity Messerli Research Institute, University of Veterinary Medicine Vienna, Medical University of Vienna, Vienna, Austria.|Institute of Pathophysiology & Allergy Research, Center of Pathophysiology, Infectiology & Immunology, Medical University Vienna, Vienna, Austria.
authors.forename: J
authors.initials: J
authors.lastname: Fazekas
authors.affiliation: Division of Gastroenterology, Hepatology and Nutrition Research, Department of Medicine Research, Children's University Hospital Boston, Boston, MA, USA.
authors.forename: E
authors.initials: E
authors.lastname: Fiebiger
authors.affiliation: LIRIC-Unité Mixte de Recherche 995 INSERM, Université de Lille 2, CHRU de Lille, Lille, France.
authors.forename: S
authors.initials: S
authors.lastname: Gatault
authors.affiliation: Division of Asthma, Allergy and Lung Biology, Medical Research Council and Asthma UK Centre in Allergic Mechanisms in Asthma, King's College London, London, UK.|Randall Division of Cell and Molecular Biophysics, King's College London, London, UK.|NIHR Biomedical Research Centre at Guy's and St. Thomas' Hospitals and King's College London, King's College London, Guy's Hospital, London, UK.
authors.forename: H J
authors.initials: HJ
authors.lastname: Gould
authors.affiliation: Center Pigmod, Institute of Animal Physiology and Genetics, Academy of Sciences of Czech Republic, Libechov, Czech Republic.
authors.forename: J
authors.initials: J
authors.lastname: Janda
authors.affiliation: Division of Genetics & Molecular Medicine, Faculty of Life Sciences and Medicine, St. John's Institute of Dermatology, King's College London, London, UK.|Division of Cancer Studies, Faculty of Life Sciences & Medicine, King's College London, Guy's Hospital, London, UK.
authors.forename: D H
authors.initials: DH
authors.lastname: Josephs
authors.affiliation: Division of Genetics & Molecular Medicine, Faculty of Life Sciences and Medicine, St. John's Institute of Dermatology, King's College London, London, UK.|NIHR Biomedical Research Centre at Guy's and St. Thomas' Hospitals and King's College London, King's College London, Guy's Hospital, London, UK.
authors.forename: P
authors.initials: P
authors.lastname: Karagiannis
authors.affiliation: Pharmacology and Experimental Therapeutics Unit, Faculty of Medicine, School of Pharmacy, The Institute for Drug Research, The Hebrew University of Jerusalem, Jerusalem, Israel.
authors.forename: F
authors.initials: F
authors.lastname: Levi-Schaffer
authors.affiliation: Institute of Pathophysiology & Allergy Research, Center of Pathophysiology, Infectiology & Immunology, Medical University Vienna, Vienna, Austria.
authors.forename: A
authors.initials: A
authors.lastname: Meshcheryakova
authors.affiliation: Institute of Pathophysiology & Allergy Research, Center of Pathophysiology, Infectiology & Immunology, Medical University Vienna, Vienna, Austria.
authors.forename: D
authors.initials: D
authors.lastname: Mechtcheriakova
authors.affiliation: Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
authors.forename: Y
authors.initials: Y
authors.lastname: Mekori
authors.affiliation: Institute of Pathophysiology & Allergy Research, Center of Pathophysiology, Infectiology & Immunology, Medical University Vienna, Vienna, Austria.
authors.forename: F
authors.initials: F
authors.lastname: Mungenast
authors.affiliation: IRCCS San Raffaele Scientific Institute, Milan, Italy.
authors.forename: E A
authors.initials: EA
authors.lastname: Nigro
authors.affiliation: Division of Surgical Oncology, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.|Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.|Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA, USA.
authors.forename: M L
authors.initials: ML
authors.lastname: Penichet
authors.affiliation: Division of Pharmacology, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.
authors.forename: F
authors.initials: F
authors.lastname: Redegeld
authors.affiliation: Division of Genetics & Molecular Medicine, Faculty of Life Sciences and Medicine, St. John's Institute of Dermatology, King's College London, London, UK.|Division of Cancer Studies, Faculty of Life Sciences & Medicine, King's College London, Guy's Hospital, London, UK.
authors.forename: L
authors.initials: L
authors.lastname: Saul
authors.affiliation: Institute of Pathophysiology & Allergy Research, Center of Pathophysiology, Infectiology & Immunology, Medical University Vienna, Vienna, Austria.
authors.forename: J
authors.initials: J
authors.lastname: Singer
authors.affiliation: Division of Cancer Studies, Faculty of Life Sciences & Medicine, King's College London, Guy's Hospital, London, UK.|NIHR Biomedical Research Centre at Guy's and St. Thomas' Hospitals and King's College London, King's College London, Guy's Hospital, London, UK.
authors.forename: J F
authors.initials: JF
authors.lastname: Spicer
authors.affiliation: IRCCS San Raffaele Scientific Institute, Milan, Italy.
authors.forename: A G
authors.initials: AG
authors.lastname: Siccardi
authors.affiliation: Immunological Engineering, Department of Engineering, Aarhus University, Aarhus, Denmark.
authors.forename: E
authors.initials: E
authors.lastname: Spillner
authors.affiliation: ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.|Universitat Pompeu Fabra (UPF), Barcelona, Spain.|CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.|McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa, ON, Canada.
authors.forename: M C
authors.initials: MC
authors.lastname: Turner
authors.affiliation: Institute of Pathophysiology & Allergy Research, Center of Pathophysiology, Infectiology & Immunology, Medical University Vienna, Vienna, Austria.
authors.forename: E
authors.initials: E
authors.lastname: Untersmayr
authors.affiliation: Department of Biomedical Sciences, Nazarbayev University School of Medicine, Astana, Kazakhstan.
authors.forename: L
authors.initials: L
authors.lastname: Vangelista
authors.affiliation: Division of Genetics & Molecular Medicine, Faculty of Life Sciences and Medicine, St. John's Institute of Dermatology, King's College London, London, UK.|NIHR Biomedical Research Centre at Guy's and St. Thomas' Hospitals and King's College London, King's College London, Guy's Hospital, London, UK.
authors.forename: S N
authors.initials: SN
authors.lastname: Karagiannis
mesh_terms: D000906:Antibodies; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D007073:Immunoglobulin E / Q000276:immunology; D007157:Immunologic Surveillance; D007167:Immunotherapy / Q000379:methods* / Q000639:trends; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy; D018418:Th2 Cells / Q000276:immunology
chemical_list: D000906:Antibodies; D007073:Immunoglobulin E
keywords: AllergoOncology; IgE; IgG4; allergy; atopy; biologics, desensitization; cancer; chemotherapeutic; clinical oncology; inflammation; tumor