title: Pemetrexed for epithelioid haemangioendothelioma of the pleura.
abstract: A 31-year-old woman presented with a 2-month history of dull left back pain. Chest roentgenography revealed pleural thickening in the left lung apex, whereas chest computed tomography showed a left pleural effusion with diffuse pleural thickening. Based on these findings, malignant mesothelioma was suspected. Video-assisted thoracoscopic pleural biopsy was performed, and subsequent staining of the specimen revealed negative results for anti-cytokeratin antibodies and positive results for vascular endothelial immunohistochemical markers. Therefore, a diagnosis of epithelioid hemangioendothelioma (EHE) was made, and chemotherapy with carboplatin, pemetrexed, and bevacizumab was initiated. After the fourth course of treatment, the disease was well controlled with a 90% reduction of the left pleural effusion. This case is very rare in that the EHE originated from the pleura. Additionally, there has been no report of pemetrexed for treatment of EHE.
authors.affiliation: Department of Respiratory Medicine Hyogo College of Medicine Hyogo Japan.
authors.forename: Shingo
authors.initials: S
authors.lastname: Kanemura
authors.affiliation: Department of Respiratory Medicine Hyogo College of Medicine Hyogo Japan.
authors.forename: Kozo
authors.initials: K
authors.lastname: Kuribayashi
authors.affiliation: Department of Respiratory Medicine Hyogo College of Medicine Hyogo Japan.
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Moriya
authors.affiliation: Department of Pathology Hyogo College of Medicine Hyogo Japan.
authors.forename: Shigeki
authors.initials: S
authors.lastname: Shimizu
authors.affiliation: Department of Pathology Hyogo College of Medicine Hyogo Japan.
authors.forename: Tohru
authors.initials: T
authors.lastname: Tsujimura
authors.affiliation: Department of Respiratory Medicine Hyogo College of Medicine Hyogo Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakano
keywords: Epithelioid hemangioendothelioma; malignant pleural mesothelioma; pemetrexed; pleura; pleural effusion