title: The effect of melatonin on endothelial dysfunction in patient undergoing coronary artery bypass grafting surgery.
abstract: BACKGROUND
  In this study, we investigated the effect of melatonin administration on four markers of endothelial cell function including intercellular adhesion molecule (ICAM), vascular cell adhesion molecule (VCAM), C-reactive protein (CRP), and nitric oxide (NO) on patients with three vessels coronary disease.
  
  
  METHODS
  This double-blind, randomized, controlled trial study was conducted on 39 patients (32 men and 7 women) with three vessels coronary disease. The case group included 20 patients who received 10 mg oral melatonin 1 h before sleeping for 1 month. The control group included 19 patients who received placebo 1 h before sleeping for 1 month. The serum levels of CRP, ICAM, VCAM, and NO were compared after 1 month treatment.
  
  
  RESULTS
  After 1 month of melatonin treatment, the mean level of ICAM, VCAM, and CRP showed a statistically significant decrease in the case group. On the other hand, the mean level of VCAM increased significantly in the control group. The mean levels of CRP and ICAM were also increased in the control group, but the difference did not reach the significant threshold. With respect to NO, there was a statistically significant increase in the case group, while there was a statistically significant decrease in serum NO in the control group.
  
  
  CONCLUSIONS
  The results of this study suggested that melatonin may have beneficial effects on endothelial oxidative stress even in patient with severe and advanced atherosclerosis.
authors.affiliation: Department of Physiology, Physiology Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Shaghayegh Haghjooy
authors.initials: SH
authors.lastname: Javanmard
authors.affiliation: Department of Physiology, Physiology Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Kiyan
authors.initials: K
authors.lastname: Heshmat-Ghahdarijani
authors.affiliation: Department of Cardiac Surgery, Isfahan Medical School, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Mirmohammad-Sadeghi
authors.affiliation: Department of Physiology, Physiology Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Sayed Ali
authors.initials: SA
authors.lastname: Sonbolestan
authors.affiliation: Medical Student Research Center, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Amin
authors.initials: A
authors.lastname: Ziayi
keywords: Computer-aided design; endothelial dysfunction; intercellular adhesion molecule; melatonin; vascular cell adhesion molecule