title: Overexpression and clinical significance of MYC-associated zinc finger protein in pancreatic carcinoma.
abstract: This study aimed to investigate the expression and clinical significance of MYC-associated zinc finger protein (MAZ) in pancreatic carcinoma (PC), and the biological functions of MAZ in PC cells. MAZ expression was detected in 57 PC tissues and 41 paired adjacent nontumor tissues by immunohistochemistry. Compared to the expression in adjacent nontumor tissues, MAZ was significantly higher expressed in PC tissues (P<0.0001). In addition, MAZ expression had a significant correlation with certain clinical characteristics of PC patients, such as age, tumor diameter, tumor number, and the serum level of CA199 (P<0.05). The survival analysis showed that the survival time of PC patients with high expression of MAZ was significantly lower than patients with low expression of MAZ (P=0.0365). After MAZ was knocked down in PANC-1 cells by RNA interference, the cells' ability to proliferate, invade, and migrate was decreased significantly (P<0.01). Moreover, MAZ expression was found to be associated with Ki-67, a cell proliferation marker, in PC tissues, further supporting the idea that MAZ promotes PC cell proliferation. Our study clarifies an oncogenic role of MAZ in pathogenesis of PC and provides MAZ as a biomarker in the treatment and prognosis of PC.
authors.affiliation: School of Public Health, Guilin Medical University, Guilin, People's Republic of China.
authors.forename: Xiaonian
authors.initials: X
authors.lastname: Zhu
authors.affiliation: Department of Hepatobiliary Surgery, The Affiliated Hospital of Guilin Medical University, Guilin, People's Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: Luo
authors.affiliation: Department of Hepatobiliary Surgery, The Affiliated Hospital of Guilin Medical University, Guilin, People's Republic of China.
authors.forename: Wenjin
authors.initials: W
authors.lastname: Liang
authors.affiliation: Department of Hepatology, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guilin, People's Republic of China.
authors.forename: Fen
authors.initials: F
authors.lastname: Tang
authors.affiliation: School of Public Health, Guilin Medical University, Guilin, People's Republic of China.
authors.forename: Chunhua
authors.initials: C
authors.lastname: Bei
authors.affiliation: School of Public Health, Guilin Medical University, Guilin, People's Republic of China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Ren
authors.affiliation: School of Public Health, Guilin Medical University, Guilin, People's Republic of China.
authors.forename: Linyuan
authors.initials: L
authors.lastname: Qin
authors.affiliation: School of Public Health, Guilin Medical University, Guilin, People's Republic of China.
authors.forename: Chao
authors.initials: C
authors.lastname: Tan
authors.affiliation: School of Public Health, Guilin Medical University, Guilin, People's Republic of China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: School of Public Health, Guilin Medical University, Guilin, People's Republic of China.
authors.forename: Shengkui
authors.initials: S
authors.lastname: Tan
keywords: MYC-associated zinc finger protein; cell proliferation; pancreatic carcinoma; prognosis