title: Intrinsic functional connectivity of fronto-temporal networks in adolescents with early psychosis.
abstract: Adults with psychotic disorders have abnormal connectivity of fronto-temporal networks. However, whether these abnormalities are present in adolescents with early psychosis has not been fully assessed. One-hundred and thirty-nine adolescents aged 12-18 underwent resting-state functional magnetic resonance imaging and diffusion tensor imaging. Following motion correction, data were available for 44 participants with a psychosis risk syndrome, 34 patients with a first episode psychosis (FEP) and 35 healthy controls. Independent component analysis was performed to assess functional networks showing a fronto-temporal scope; this identified a language and a salience network. Mean fractional anisotropy was measured in clusters showing between-group differences in intrinsic functional connectivity (iFC). For the language network, there was a group effect within the right middle/inferior frontal gyrus, explained by reduced iFC in patients with an FEP relative to healthy controls, while in participants with a psychosis risk syndrome values of iFC were intermediate. In this region, values of iFC were positively correlated with mean fractional anisotropy in patients with an FEP. No group differences were observed in the salience network. Reduced iFC of the language network, in association with disrupted white matter microstructure, may characterize FEP during adolescence.
authors.affiliation: August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Solé-Padullés
authors.affiliation: August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.|Department of Child and Adolescent Psychiatry and Psychology, SGR489, Institute of Neuroscience, Hospital Clínic of Barcelona, C/Villarroel 170, 08036, Barcelona, Spain.|Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain.|Biomedical Research Networking Centre Consortium (CIBERSAM), Madrid, Spain.
authors.forename: Josefina
authors.initials: J
authors.lastname: Castro-Fornieles
authors.affiliation: Biomedical Research Networking Centre Consortium (CIBERSAM), Madrid, Spain.
authors.forename: Elena
authors.initials: E
authors.lastname: de la Serna
authors.affiliation: Biomedical Research Networking Centre Consortium (CIBERSAM), Madrid, Spain.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Sánchez-Gistau
authors.affiliation: August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.|Department of Child and Adolescent Psychiatry and Psychology, SGR489, Institute of Neuroscience, Hospital Clínic of Barcelona, C/Villarroel 170, 08036, Barcelona, Spain.|Biomedical Research Networking Centre Consortium (CIBERSAM), Madrid, Spain.
authors.forename: Soledad
authors.initials: S
authors.lastname: Romero
authors.affiliation: Department of Child and Adolescent Psychiatry and Psychology, SGR489, Institute of Neuroscience, Hospital Clínic of Barcelona, C/Villarroel 170, 08036, Barcelona, Spain.
authors.forename: Olga
authors.initials: O
authors.lastname: Puig
authors.affiliation: August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.
authors.forename: Anna
authors.initials: A
authors.lastname: Calvo
authors.affiliation: Biomedical Research Networking Centre Consortium (CIBERSAM), Madrid, Spain.|Magnetic Resonance Imaging Core Facility, Hospital Clinic of Barcelona, Barcelona, Spain.|Centre for Diagnostic Imaging (CDI), Hospital Clinic of Barcelona, Barcelona, Spain.
authors.forename: Nuria
authors.initials: N
authors.lastname: Bargalló
authors.affiliation: August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.|Department of Child and Adolescent Psychiatry and Psychology, SGR489, Institute of Neuroscience, Hospital Clínic of Barcelona, C/Villarroel 170, 08036, Barcelona, Spain.|Biomedical Research Networking Centre Consortium (CIBERSAM), Madrid, Spain.
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Baeza
authors.affiliation: August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain. gernest@clinic.cat.|Department of Child and Adolescent Psychiatry and Psychology, SGR489, Institute of Neuroscience, Hospital Clínic of Barcelona, C/Villarroel 170, 08036, Barcelona, Spain. gernest@clinic.cat.|Biomedical Research Networking Centre Consortium (CIBERSAM), Madrid, Spain. gernest@clinic.cat.
authors.forename: Gisela
authors.initials: G
authors.lastname: Sugranyes
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D005625:Frontal Lobe / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D011618:Psychotic Disorders / Q000473:pathology / Q000523:psychology*
keywords: Child and adolescent psychiatry; Neuroimaging; Psychosis