title: Genomic sequencing and precision medicine in head and neck cancers.
abstract: Head and neck squamous cell carcinoma (HNSCC) remains a common and deadly disease. Historically, surgical and chemoradiation treatments have been met with modest success, and understanding of genetic drivers of HNSCC has been limited. With recent next generation sequencing studies focused on HNSCC, we are beginning to understand the genetic landscape of HNSCCs and are starting to identify and advance targeted options for patients. In this review, we describe current knowledge and recent advances in sequencing studies of HNSCC, discuss current limitations and future directions for further genomic analysis, and highlight the translational advances being undertaken to treat this important disease.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA.
authors.forename: R C
authors.initials: RC
authors.lastname: Hoesli
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA.
authors.forename: M L
authors.initials: ML
authors.lastname: Ludwig
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA.
authors.forename: N L
authors.initials: NL
authors.lastname: Michmerhuizen
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA.
authors.forename: A J
authors.initials: AJ
authors.lastname: Rosko
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA; Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, USA.
authors.forename: M E
authors.initials: ME
authors.lastname: Spector
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA; Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, USA.
authors.forename: J C
authors.initials: JC
authors.lastname: Brenner
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA. Electronic address: abirkela@med.umich.edu.
authors.forename: A C
authors.initials: AC
authors.lastname: Birkeland
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000235:genetics*; D004252:DNA Mutational Analysis; D006258:Head and Neck Neoplasms / Q000188:drug therapy / Q000235:genetics*; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D058990:Molecular Targeted Therapy; D057285:Precision Medicine; D057170:Translational Research, Biomedical
chemical_list: D000970:Antineoplastic Agents
keywords: Genomics; HNSCC; Head and neck cancer; Personalized medicine; Precision medicine