title: Cutaneous changes in internal malignancy: Study from a tertiary care center.
abstract: BACKGROUND
  A wide variety of systemic diseases and internal malignancies have cutaneous manifestations. In the context of internal malignancy, many cutaneous changes are highly specific to the underlying malignancy, while other changes are nonspecific. Some changes are also due to the modalities employed in the treatment of malignancies.
  
  
  METHODS
  Two hundred and fifty patients who were diagnosed with internal malignancy and who were attending the department of radiation oncology, were evaluated at the Department of Dermatology, Sexually Transmitted Diseases and Leprosy of Government Medical College, Srinagar. The study was conducted over a period of 5 months. Relevant investigations, wherever needed, were carried out.
  
  
  RESULTS
  Among the 250 cases examined, nonspecific cutaneous changes were seen in 39 (15.6%) cases, whereas specific skin lesions in the form of cutaneous metastases were seen in two (0.8%) patients. Nail changes and hair changes were also seen in some patients.
  
  
  CONCLUSIONS
  As this was a cross-sectional study and most of the patients were lost to follow up, we could not assess the outcome of the dermatological changes seen in the affected patients.
  
  
  CONCLUSIONS
  Many dermatological changes are noticed early in the course of malignancy, reflecting a strong association of the cutaneous change with malignancy. Few manifestations occur late in the course of the disease, indicating dissemination or immunosuppression. Some changes reflect radiation-induced or chemotherapy-induced toxicity, indicating the need for treatment modifications.
authors.affiliation: Department of Dermatology, Sexually Transmitted Diseases and Leprosy, Government Medical College Srinagar, University of Kashmir, Srinagar, Jammu and Kashmir, India.
authors.forename: Iffat
authors.initials: I
authors.lastname: Hassan
authors.affiliation: Department of Dermatology, Sexually Transmitted Diseases and Leprosy, Government Medical College Srinagar, University of Kashmir, Srinagar, Jammu and Kashmir, India.
authors.forename: Sumaya
authors.initials: S
authors.lastname: Zeerak
authors.affiliation: Department of Radiation Oncology, Government Medical College Srinagar, University of Kashmir, Srinagar, Jammu and Kashmir, India.
authors.forename: Sanaullah
authors.initials: S
authors.lastname: Kuchay
authors.affiliation: Department of Dermatology, Sexually Transmitted Diseases and Leprosy, Government Medical College Srinagar, University of Kashmir, Srinagar, Jammu and Kashmir, India.
authors.forename: Safia
authors.initials: S
authors.lastname: Bashir
authors.affiliation: Department of Dermatology, Sexually Transmitted Diseases and Leprosy, Government Medical College Srinagar, University of Kashmir, Srinagar, Jammu and Kashmir, India.
authors.forename: Yasmeen J
authors.initials: YJ
authors.lastname: Bhat
authors.affiliation: Department of Dermatology, Sexually Transmitted Diseases and Leprosy, Government Medical College Srinagar, University of Kashmir, Srinagar, Jammu and Kashmir, India.
authors.forename: Syed
authors.initials: S
authors.lastname: Mubashir
authors.affiliation: Department of Dermatology, Sexually Transmitted Diseases and Leprosy, Government Medical College Srinagar, University of Kashmir, Srinagar, Jammu and Kashmir, India.
authors.forename: Farhan
authors.initials: F
authors.lastname: Rasool
authors.affiliation: Department of Dermatology, Sexually Transmitted Diseases and Leprosy, Government Medical College Srinagar, University of Kashmir, Srinagar, Jammu and Kashmir, India.
authors.forename: Gousia
authors.initials: G
authors.lastname: Sheikh
authors.affiliation: Department of Dermatology, Sexually Transmitted Diseases and Leprosy, Government Medical College Srinagar, University of Kashmir, Srinagar, Jammu and Kashmir, India.
authors.forename: Peerzada
authors.initials: P
authors.lastname: Sajad
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000175:diagnosis / Q000453:epidemiology; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000453:epidemiology* / Q000556:secondary; D062606:Tertiary Care Centers / Q000639:trends*; D055815:Young Adult