title: Metabolic roles of poly(ADP-ribose) polymerases.
abstract: Poly(ADP-ribosyl)ation (PARylation) is an evolutionarily conserved reaction that had been associated with numerous cellular processes such as DNA repair, protein turnover, inflammatory regulation, aging or metabolic regulation. The metabolic regulatory tasks of poly(ADP-ribose) polymerases (PARPs) are complex, it is based on the regulation of metabolic transcription factors (e.g. SIRT1, nuclear receptors, SREBPs) and certain cellular energy sensors. PARP over-activation can cause damage to mitochondrial terminal oxidation, while the inhibition of PARP-1 or PARP-2 can induce mitochondrial oxidation by enhancing the mitotropic tone of gene transcription and signal transduction. These PARP-mediated processes impact on higher order metabolic regulation that modulates lipid metabolism, circadian oscillations and insulin secretion and signaling. PARP-1, PARP-2 and PARP-7 are related to metabolic diseases such as diabetes, alcoholic and non-alcoholic fatty liver disease (AFLD, NAFLD), or on a broader perspective to Warburg metabolism in cancer or the metabolic diseases accompanying aging.
authors.affiliation: Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, 4032, Hungary; MTA-DE Lendület Laboratory of Cellular Metabolism, Debrecen, H-4032, Hungary.
authors.forename: András
authors.initials: A
authors.lastname: Vida
authors.affiliation: Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, 4032, Hungary.
authors.forename: Judit
authors.initials: J
authors.lastname: Márton
authors.affiliation: Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, 4032, Hungary; MTA-DE Lendület Laboratory of Cellular Metabolism, Debrecen, H-4032, Hungary.
authors.forename: Edit
authors.initials: E
authors.lastname: Mikó
authors.affiliation: Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, 4032, Hungary; MTA-DE Lendület Laboratory of Cellular Metabolism, Debrecen, H-4032, Hungary; Research Center for Molecular Medicine, Faculty of Medicine University of Debrecen, 4032, Hungary. Electronic address: baip@med.unideb.hu.
authors.forename: Péter
authors.initials: P
authors.lastname: Bai
mesh_terms: D000818:Animals; D004734:Energy Metabolism; D015971:Gene Expression Regulation, Enzymologic; D006706:Homeostasis; D006801:Humans; D008659:Metabolic Diseases / Q000201:enzymology; D008928:Mitochondria / Q000378:metabolism; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism*
chemical_list: D011065:Poly(ADP-ribose) Polymerases
keywords: ARTD; Diabetes; Metabolism; Mitochondria; Obesity; PARP