title: Structural, Functional and Evolutionary Aspects of Seed Globulins.
abstract: Globulins are a major class of seed storage proteins which were thought to be enzymatically inactive. These proteins belong to the most ancient cupin superfamily. They can be graded into 11S legumin type and 7S vicilin type based on their sedimentation coefficients. Members from both classes share structural homology are thought to have evolved from either one-domain germin predecessor by duplication or by horizontal gene transfer of two-domain gene from bacteria to eukaryotes. Globulins are known to define the nutritional quality of the seeds, however, they are also involved in sucrose binding, desiccation, defense against microbes, hormone binding and oxidative stress etc. Major drawback with globulins is their tendency to bind to IgE. Studying structural-functional behavior of such protein can help in modifying proteins for enhanced functionality in food processing industries.
authors.forename: Pooja
authors.initials: P
authors.lastname: Kesari
authors.lastname: Neetu
authors.forename: Anchal
authors.initials: A
authors.lastname: Sharma
authors.forename: Madhusudhanarao
authors.initials: M
authors.lastname: Katiki
authors.forename: Pramod
authors.initials: P
authors.lastname: Kumar
authors.forename: Bhola R
authors.initials: BR
authors.lastname: Gurjar
authors.forename: Shailly
authors.initials: S
authors.lastname: Tomar
authors.forename: Ashwani K
authors.initials: AK
authors.lastname: Sharma
authors.affiliation: Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand-247667, India.
authors.forename: Pravindra
authors.initials: P
authors.lastname: Kumar
mesh_terms: D005075:Biological Evolution; D020440:Gene Duplication; D015870:Gene Expression; D022761:Gene Transfer, Horizontal; D005916:Globulins / Q000235:genetics / Q000378:metabolism; D006023:Glycoproteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007073:Immunoglobulin E / Q000235:genetics / Q000378:metabolism; D010940:Plant Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D010944:Plants / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D011485:Protein Binding; D054730:Protein Interaction Domains and Motifs; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D055314:Seed Storage Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D012639:Seeds / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D000097793:Legumins
chemical_list: D005916:Globulins; D006023:Glycoproteins; D007073:Immunoglobulin E; D010940:Plant Proteins; D055314:Seed Storage Proteins; D000097793:Legumins; C058814:germin; C015575:vicilin protein, plant
keywords: 11S legumin; 7S vicilin; Globulins; cupin superfamily; evolution; seed storage protein