title: Hybrid Markov chain models of S-I-R disease dynamics.
abstract: Deterministic epidemic models are attractive due to their compact nature, allowing substantial complexity with computational efficiency. This partly explains their dominance in epidemic modelling. However, the small numbers of infectious individuals at early and late stages of an epidemic, in combination with the stochastic nature of transmission and recovery events, are critically important to understanding disease dynamics. This motivates the use of a stochastic model, with continuous-time Markov chains being a popular choice. Unfortunately, even the simplest Markovian S-I-R model-the so-called general stochastic epidemic-has a state space of order [Formula: see text], where N is the number of individuals in the population, and hence computational limits are quickly reached. Here we introduce a hybrid Markov chain epidemic model, which maintains the stochastic and discrete dynamics of the Markov chain in regions of the state space where they are of most importance, and uses an approximate model-namely a deterministic or a diffusion model-in the remainder of the state space. We discuss the evaluation, efficiency and accuracy of this hybrid model when approximating the distribution of the duration of the epidemic and the distribution of the final size of the epidemic. We demonstrate that the computational complexity is [Formula: see text] and that under suitable conditions our approximations are highly accurate.
authors.affiliation: School of Mathematical Sciences and the ARC Centre of Excellence for Mathematical and Statistical Frontiers, University of Adelaide, Adelaide, SA, 5005, Australia. nicolas.rebuli@adelaide.edu.au.
authors.forename: Nicolas P
authors.initials: NP
authors.lastname: Rebuli
authors.affiliation: School of Mathematical Sciences and the ARC Centre of Excellence for Mathematical and Statistical Frontiers, University of Adelaide, Adelaide, SA, 5005, Australia.
authors.forename: N G
authors.initials: NG
authors.lastname: Bean
authors.affiliation: School of Mathematical Sciences and the ARC Centre of Excellence for Mathematical and Statistical Frontiers, University of Adelaide, Adelaide, SA, 5005, Australia.
authors.forename: J V
authors.initials: JV
authors.lastname: Ross
mesh_terms: D003141:Communicable Diseases / Q000453:epidemiology*; D058872:Epidemics / Q000706:statistics & numerical data*; D006801:Humans; D008390:Markov Chains; D008954:Models, Biological; D013269:Stochastic Processes
keywords: Diffusion approximation; Epidemiology; Fluid approximation; Markov population processes