title: In VitroActivity of Posaconazole against Talaromyces marneffei by Broth Microdilution and Etest Methods and Comparison to Itraconazole, Voriconazole, and Anidulafungin.
abstract: We determined the susceptibilities of 57Talaromyces marneffeistrains to anidulafungin, itraconazole, voriconazole, and posaconazole with MICs of 2 to 8, 0.002 to 0.004, 0.016 to 0.063, and 0.001 to 0.002 μg/ml by broth microdilution and >32, ≤0.002 to 0.008, ≤0.002 to 0.008, and ≤0.002 μg/ml by Etest, respectively, at yeast phase; MICs at mycelial phase for anidulafungin and posaconazole were 1 to 2 and 0.004 to 0.063 μg/ml, respectively. The results suggest promising activities of posaconazole. Etest can be used for testing of azoles againstT. marneffei.
authors.affiliation: State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China skplau@hku.hk pcywoo@hku.hk.|Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong, China.|Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong, China.|Department of Microbiology, The University of Hong Kong, Hong Kong, China.
authors.forename: Susanna K P
authors.initials: SK
authors.lastname: Lau
authors.affiliation: Department of Microbiology, The University of Hong Kong, Hong Kong, China.
authors.forename: George C S
authors.identifier: 0000-0001-9325-4322
authors.initials: GC
authors.lastname: Lo
authors.affiliation: Hong Kong Sanatorium Hospital, Hong Kong, China.
authors.forename: Clare S K
authors.initials: CS
authors.lastname: Lam
authors.affiliation: Department of Microbiology, The University of Hong Kong, Hong Kong, China.
authors.forename: Wang-Ngai
authors.identifier: 0000-0003-1275-2464
authors.initials: WN
authors.lastname: Chow
authors.affiliation: Department of Microbiology, The University of Hong Kong, Hong Kong, China.
authors.forename: Antonio H Y
authors.initials: AH
authors.lastname: Ngan
authors.affiliation: Department of Pathology, Pamela Youde Nethersole Eastern Hospital, Hong Kong, China.
authors.forename: Alan K L
authors.initials: AK
authors.lastname: Wu
authors.affiliation: Department of Pathology, Queen Elizabeth Hospital, Hong Kong, China.
authors.forename: Dominic N C
authors.initials: DN
authors.lastname: Tsang
authors.affiliation: Department of Pathology, Kwong Wah Hospital, Hong Kong, China.
authors.forename: Cindy W S
authors.initials: CW
authors.lastname: Tse
authors.affiliation: Department of Pathology, Tuen Mun Hospital, Hong Kong, China.
authors.forename: Tak-Lun
authors.initials: TL
authors.lastname: Que
authors.affiliation: Hong Kong Sanatorium Hospital, Hong Kong, China.
authors.forename: Bone S F
authors.initials: BS
authors.lastname: Tang
authors.affiliation: State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China skplau@hku.hk pcywoo@hku.hk.|Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong, China.|Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong, China.|Department of Microbiology, The University of Hong Kong, Hong Kong, China.
authors.forename: Patrick C Y
authors.initials: PC
authors.lastname: Woo
mesh_terms: D000077612:Anidulafungin; D000935:Antifungal Agents / Q000494:pharmacology*; D052978:Disk Diffusion Antimicrobial Tests; D054714:Echinocandins / Q000494:pharmacology*; D006801:Humans; D017964:Itraconazole / Q000494:pharmacology*; D010407:Penicillium / Q000187:drug effects / Q000254:growth & development; D011934:Reagent Strips; D032901:Talaromyces / Q000187:drug effects* / Q000254:growth & development / Q000302:isolation & purification; D014230:Triazoles / Q000494:pharmacology*; D065819:Voriconazole / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D011934:Reagent Strips; D014230:Triazoles; D017964:Itraconazole; C101425:posaconazole; D000077612:Anidulafungin; D065819:Voriconazole
keywords: Etest; Penicillium; Talaromyces marneffei; anidulafungin; itraconazole; posaconazole; susceptibility; voriconazole