title: The impact of body mass index and height on the risk for glioblastoma and other glioma subgroups: a large prospective cohort study.
abstract: BACKGROUND
  Glioma comprises a heterogeneous group of mostly malignant brain tumors, whereof glioblastoma (GBM) represents the largest and most lethal subgroup. Body height and body mass index (BMI) are risk factors for other cancers, but no previous study has examined anthropometric data in relation to different glioma subgroups.
  
  
  METHODS
  This prospective cohort study includes 1.8 million Norwegian women and men between ages 14 and 80 years at baseline. Body weight and height were measured, and incident cases of glioma were identified by linkage to the National Cancer Registry. Cox regression analyses were performed to evaluate risk for different glioma subgroups in relation to anthropometric measures.
  
  
  RESULTS
  During 54 million person-years of follow-up, 4,382 gliomas were identified. Overweight and obesity were not associated with risk for any glioma subgroup. Height was positively associated with risk for GBM and all other gliomas (hazard ratio [HR] per 10 cm increase: 1.24; 95% confidence interval [CI], 1.17-1.31 and 1.18; 95% CI, 1.09-1.29) but not with the proxy for isocitrate dehydrogenase (IDH)-mutant glioma (HR, 1.09; 95% CI, 0.98-1.21). In further subgroup analyses, the effect of height on glioma risk varied significantly with positive associations for oligoastrocytoma (HR, 1.74; 95% CI, 1.20-2.53) and malignant glioma not otherwise specified (NOS) (HR, 1.42; 95% CI, 1.16-1.76, but not with diffuse astrocytoma (WHO grades II and III) or oligodendroglioma.
  
  
  CONCLUSIONS
  This epidemiologic study consolidates height as a risk factor for GBM and other gliomas. It further indicates that this association is not universal for gliomas but may differ between different glioma subgroups.
authors.affiliation: Department of Neurosurgery, Oslo University Hospital, Oslo, Norway; Oslo Centre for Biostatistics and Epidemiology, Research Support Services, Oslo University Hospital, Oslo, Norway; Neurosurgery Unit, Faculty of Medicine and Health Sciences, Macquarie University, Sydney,Australia; Crown Princess Mary Cancer Care Centre, Westmead Hospital, Sydney,Australia; NHMRC Clinical Trials Centre, Sydney,Australia; Department of Gynecological Cancer, Oslo University Hospital (Norwegian Radium Hospital), Oslo, Norway; The Cancer Registry of Norway, Oslo, Norway; Department of Public Health, Norwegian University of Science and Technology, Trondheim, Norway; FORMI and Department of Neurology, Oslo University Hospital (Ulleval),Oslo, Norway; Faculty of Medicine, University of Oslo, Oslo, Norway.
authors.forename: Markus K H
authors.initials: MKH
authors.lastname: Wiedmann
authors.affiliation: Department of Neurosurgery, Oslo University Hospital, Oslo, Norway; Oslo Centre for Biostatistics and Epidemiology, Research Support Services, Oslo University Hospital, Oslo, Norway; Neurosurgery Unit, Faculty of Medicine and Health Sciences, Macquarie University, Sydney,Australia; Crown Princess Mary Cancer Care Centre, Westmead Hospital, Sydney,Australia; NHMRC Clinical Trials Centre, Sydney,Australia; Department of Gynecological Cancer, Oslo University Hospital (Norwegian Radium Hospital), Oslo, Norway; The Cancer Registry of Norway, Oslo, Norway; Department of Public Health, Norwegian University of Science and Technology, Trondheim, Norway; FORMI and Department of Neurology, Oslo University Hospital (Ulleval),Oslo, Norway; Faculty of Medicine, University of Oslo, Oslo, Norway.
authors.forename: Cathrine
authors.initials: C
authors.lastname: Brunborg
authors.affiliation: Department of Neurosurgery, Oslo University Hospital, Oslo, Norway; Oslo Centre for Biostatistics and Epidemiology, Research Support Services, Oslo University Hospital, Oslo, Norway; Neurosurgery Unit, Faculty of Medicine and Health Sciences, Macquarie University, Sydney,Australia; Crown Princess Mary Cancer Care Centre, Westmead Hospital, Sydney,Australia; NHMRC Clinical Trials Centre, Sydney,Australia; Department of Gynecological Cancer, Oslo University Hospital (Norwegian Radium Hospital), Oslo, Norway; The Cancer Registry of Norway, Oslo, Norway; Department of Public Health, Norwegian University of Science and Technology, Trondheim, Norway; FORMI and Department of Neurology, Oslo University Hospital (Ulleval),Oslo, Norway; Faculty of Medicine, University of Oslo, Oslo, Norway.
authors.forename: Antonio
authors.initials: A
authors.lastname: Di Ieva
authors.affiliation: Department of Neurosurgery, Oslo University Hospital, Oslo, Norway; Oslo Centre for Biostatistics and Epidemiology, Research Support Services, Oslo University Hospital, Oslo, Norway; Neurosurgery Unit, Faculty of Medicine and Health Sciences, Macquarie University, Sydney,Australia; Crown Princess Mary Cancer Care Centre, Westmead Hospital, Sydney,Australia; NHMRC Clinical Trials Centre, Sydney,Australia; Department of Gynecological Cancer, Oslo University Hospital (Norwegian Radium Hospital), Oslo, Norway; The Cancer Registry of Norway, Oslo, Norway; Department of Public Health, Norwegian University of Science and Technology, Trondheim, Norway; FORMI and Department of Neurology, Oslo University Hospital (Ulleval),Oslo, Norway; Faculty of Medicine, University of Oslo, Oslo, Norway.
authors.forename: Kristina
authors.initials: K
authors.lastname: Lindemann
authors.affiliation: Department of Neurosurgery, Oslo University Hospital, Oslo, Norway; Oslo Centre for Biostatistics and Epidemiology, Research Support Services, Oslo University Hospital, Oslo, Norway; Neurosurgery Unit, Faculty of Medicine and Health Sciences, Macquarie University, Sydney,Australia; Crown Princess Mary Cancer Care Centre, Westmead Hospital, Sydney,Australia; NHMRC Clinical Trials Centre, Sydney,Australia; Department of Gynecological Cancer, Oslo University Hospital (Norwegian Radium Hospital), Oslo, Norway; The Cancer Registry of Norway, Oslo, Norway; Department of Public Health, Norwegian University of Science and Technology, Trondheim, Norway; FORMI and Department of Neurology, Oslo University Hospital (Ulleval),Oslo, Norway; Faculty of Medicine, University of Oslo, Oslo, Norway.
authors.forename: Tom B
authors.initials: TB
authors.lastname: Johannesen
authors.affiliation: Department of Neurosurgery, Oslo University Hospital, Oslo, Norway; Oslo Centre for Biostatistics and Epidemiology, Research Support Services, Oslo University Hospital, Oslo, Norway; Neurosurgery Unit, Faculty of Medicine and Health Sciences, Macquarie University, Sydney,Australia; Crown Princess Mary Cancer Care Centre, Westmead Hospital, Sydney,Australia; NHMRC Clinical Trials Centre, Sydney,Australia; Department of Gynecological Cancer, Oslo University Hospital (Norwegian Radium Hospital), Oslo, Norway; The Cancer Registry of Norway, Oslo, Norway; Department of Public Health, Norwegian University of Science and Technology, Trondheim, Norway; FORMI and Department of Neurology, Oslo University Hospital (Ulleval),Oslo, Norway; Faculty of Medicine, University of Oslo, Oslo, Norway.
authors.forename: Lars
authors.initials: L
authors.lastname: Vatten
authors.affiliation: Department of Neurosurgery, Oslo University Hospital, Oslo, Norway; Oslo Centre for Biostatistics and Epidemiology, Research Support Services, Oslo University Hospital, Oslo, Norway; Neurosurgery Unit, Faculty of Medicine and Health Sciences, Macquarie University, Sydney,Australia; Crown Princess Mary Cancer Care Centre, Westmead Hospital, Sydney,Australia; NHMRC Clinical Trials Centre, Sydney,Australia; Department of Gynecological Cancer, Oslo University Hospital (Norwegian Radium Hospital), Oslo, Norway; The Cancer Registry of Norway, Oslo, Norway; Department of Public Health, Norwegian University of Science and Technology, Trondheim, Norway; FORMI and Department of Neurology, Oslo University Hospital (Ulleval),Oslo, Norway; Faculty of Medicine, University of Oslo, Oslo, Norway.
authors.forename: Eirik
authors.initials: E
authors.lastname: Helseth
authors.affiliation: Department of Neurosurgery, Oslo University Hospital, Oslo, Norway; Oslo Centre for Biostatistics and Epidemiology, Research Support Services, Oslo University Hospital, Oslo, Norway; Neurosurgery Unit, Faculty of Medicine and Health Sciences, Macquarie University, Sydney,Australia; Crown Princess Mary Cancer Care Centre, Westmead Hospital, Sydney,Australia; NHMRC Clinical Trials Centre, Sydney,Australia; Department of Gynecological Cancer, Oslo University Hospital (Norwegian Radium Hospital), Oslo, Norway; The Cancer Registry of Norway, Oslo, Norway; Department of Public Health, Norwegian University of Science and Technology, Trondheim, Norway; FORMI and Department of Neurology, Oslo University Hospital (Ulleval),Oslo, Norway; Faculty of Medicine, University of Oslo, Oslo, Norway.
authors.forename: John A
authors.initials: JA
authors.lastname: Zwart
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001827:Body Height; D015992:Body Mass Index; D001932:Brain Neoplasms / Q000150:complications / Q000453:epidemiology*; D015331:Cohort Studies; D005260:Female; D005909:Glioblastoma / Q000150:complications / Q000453:epidemiology*; D005910:Glioma / Q000150:complications / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000453:epidemiology; D011446:Prospective Studies; D012307:Risk Factors; D055815:Young Adult
keywords: body mass index; cohort study; glioma; height; risk factor