title: Selected flavonoid compounds as promising inhibitors of protein kinase CK2α and CK2α', the catalytic subunits of CK2.
abstract: CK2 is a ubiquitous protein kinase involved in many cell functions. During the last years it became an interesting target in cancer research. A series of flavonoid compounds was tested as inhibitors of protein kinase CK2. Several substances were found to be highly active against both catalytic subunits with IC50values below 1 μM in case of CK2α'. The most promising inhibitor we identified is chrysoeriol with IC50values of 250 and 34 nM for CK2α and CK2α', respectively.
authors.affiliation: Department of Molecular Biology, The John Paul II Catholic University of Lublin, ul. Konstantynów 1i, 20-708 Lublin, Poland. Electronic address: baier@kul.pl.
authors.forename: Andrea
authors.initials: A
authors.lastname: Baier
authors.affiliation: Department of Medical Chemistry, Medical University of Białystok, ul. Mickiewicza 2a, 15-089 Białystok, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Galicka
authors.affiliation: Department of Pharmacognosy, Medical University of Białystok, ul. Mickiewicza 2a, 15-089 Białystok, Poland.
authors.forename: Jolanta
authors.initials: J
authors.lastname: Nazaruk
authors.affiliation: Department of Molecular Biology, The John Paul II Catholic University of Lublin, ul. Konstantynów 1i, 20-708 Lublin, Poland.
authors.forename: Ryszard
authors.initials: R
authors.lastname: Szyszka
mesh_terms: D000595:Amino Acid Sequence; D047390:Casein Kinase II / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D020134:Catalytic Domain; D047309:Flavones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure
chemical_list: D047309:Flavones; C570325:CSNK2A1 protein, human; D047390:Casein Kinase II; C007054:chrysoeriol
keywords: Chrysoeriol; Flavonoids; Inhibitors; Protein kinase CK2