title: Synthetic Strategies Employed for the Construction of Fostriecin and Related Natural Products.
abstract: Fostriecin and related natural products present a significant challenge for synthetic chemists due to their structural complexity and chemical sensitivity. This review will chronicle the successful efforts of synthetic chemists in the construction of these biologically active molecules. Key carbon-carbon bond forming reactions will be highlighted, as well as the methods used to install the numerous stereocenters present in this class of compounds.
authors.affiliation: Department of Chemistry, Stanford University , Stanford, California 94305-5080, United States.
authors.forename: Barry M
authors.initials: BM
authors.lastname: Trost
authors.affiliation: Department of Chemistry, Trinity College , 300 Summit Street, Hartford, Connecticut 06106, United States.
authors.forename: Joshua D
authors.initials: JD
authors.lastname: Knopf
authors.affiliation: Department of Chemistry, Trinity College , 300 Summit Street, Hartford, Connecticut 06106, United States.
authors.forename: Cheyenne S
authors.initials: CS
authors.lastname: Brindle
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis; D001688:Biological Products / Q000138:chemical synthesis*; D003500:Cyclization; D061565:Cycloaddition Reaction; D006900:Hydroxylation; D007783:Lactones / Q000138:chemical synthesis; D011090:Polyenes / Q000138:chemical synthesis*; D011753:Pyrones / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D001688:Biological Products; D007783:Lactones; D011090:Polyenes; D011753:Pyrones; C040315:PD 113271; C040313:fostriecin