title: Secondary Metabolites from Cissampelos, A Possible Source for New Leads with Anti-Inflammatory Activity.
abstract: The genus Cissampelos comprises of 21 species which have a wide global distribution and various pharmacological activities such as analgesic and antipyretic, antiinflammatory, anti-allergic, bronchodilation, and immunomodulation among others. Several compounds, mainly alkaloids with differing biological activities have been isolated from this genus. We will highlight antipyretic activities, anti-inflammatory, antiallergic, bronchodilatory, and immunomodulatory activities. In addition, we applied ligand-based-virtual screening associated with structure-based-virtual screening of a small dataset of 63 secondary metabolites from the Cissampelos genus of an in-house data bank, in order to select compounds with potential anti-inflammatory activity. Affinities were observed for hayatine (26), isochondrondendrine (30), pelosine (52), sepeerine (59), and warifteine (63) to the inhibiting enzymes MAPK p38 alpha, PKC beta, PKC theta and PKC zeta. The cissampeloflavone compound (8) alone showed no potential inhibitory activity for PKC zeta, or affinity for the PKC alpha. The compounds can be used as starting points for further studies on structures with potential anti-inflammatory activity.
authors.affiliation: Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa - PB, Brazil.
authors.forename: Mateus F
authors.initials: MF
authors.lastname: Alves
authors.affiliation: Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa - PB, Brazil.
authors.forename: Marcus T
authors.initials: MT
authors.lastname: Scotti
authors.affiliation: Health Sciences Center, Federal University of Paraíba, Campus I, 58051-970, João Pessoa- PB, Brazil.
authors.forename: Luciana
authors.initials: L
authors.lastname: Scotti
authors.affiliation: Laboratory of Synthesis and Drug Delivery, Department of Biological Science, State University of Paraiba, João Pessoa, PB, Brazil.
authors.forename: Francisco Jaime Bezerra
authors.initials: FJB
authors.lastname: Mendonça
authors.affiliation: Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa - PB, Brazil.
authors.forename: José M B
authors.initials: JMB
authors.lastname: Filho
authors.affiliation: Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa - PB, Brazil.
authors.forename: Sílvia A L
authors.initials: SAL
authors.lastname: de Melo
authors.affiliation: Research Institute for Drugs and Medicines, Federal University of Paraíba, João Pessoa - PB, Brazil.
authors.forename: Sócrates G
authors.initials: SG
authors.lastname: Dos Santos
authors.affiliation: Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa - PB, Brazil.
authors.forename: Margareth
authors.initials: M
authors.lastname: de F F M Diniz
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism; D001665:Binding Sites; D031606:Cissampelos / Q000737:chemistry* / Q000378:metabolism; D062105:Molecular Docking Simulation; D011493:Protein Kinase C / Q000037:antagonists & inhibitors / Q000378:metabolism; D021122:Protein Subunits / Q000037:antagonists & inhibitors / Q000378:metabolism; D048051:p38 Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D000470:Alkaloids; D000893:Anti-Inflammatory Agents; D021122:Protein Subunits; D011493:Protein Kinase C; D048051:p38 Mitogen-Activated Protein Kinases
keywords: Cissampelos; anti-inflammatory activity; asthma; multi-target; secondary metabolites; virtual screening