title: Skin fragility in the wild-derived, inbred mouse strain Mus pahari/EiJ.
abstract: Mus pahari is a wild-derived, inbred mouse strain. M. pahari colony managers observed fragility of this strain's skin resulting in separation of tail skin from the mouse if handled incorrectly. Tail skin tension testing of M. pahari resulted in significantly lowered force threshold for caudal skin rupture and loss in comparison to closely related inbred mouse species and subspecies and even more than a model for junctional epidermolysis bullosa. Histologically, the tail skin separated at the subdermal level with the dermis firmly attached to the epidermis, excluding the epidermolysis bullosa complex of diseases. The dermal collagen bundles were abnormally thickened and branched. Elastin fiber deposition was focally altered in the dermis adjacent to the hair follicle. Collagens present in the skin could not be differentiated between the species in protein gels following digestion with pepsin. Together these data suggest that M. pahari have altered extracellular matrix development resulting in separation of the skin below the level of the dermis with moderate force similar to the African spiny mouse (Acomys spp.).
authors.affiliation: The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609-1500, USA. Electronic address: Herbert.Pratt@jax.org.
authors.forename: C
authors.initials: C
authors.lastname: Herbert Pratt
authors.affiliation: The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609-1500, USA.
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Potter
authors.affiliation: Dept. of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Raoul V
authors.initials: RV
authors.lastname: Kuiper
authors.affiliation: The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609-1500, USA.
authors.forename: Son Yong
authors.initials: SY
authors.lastname: Karst
authors.affiliation: Dept. of Dermatology, University of Connecticut Health Center, Farmington, CT, USA; Dept. of Genetics/Developmental Biology, University of Connecticut Health Center, Farmington, CT, USA.
authors.forename: Soheil S
authors.initials: SS
authors.lastname: Dadras
authors.affiliation: The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609-1500, USA.
authors.forename: Derry C
authors.initials: DC
authors.lastname: Roopenian
authors.affiliation: The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609-1500, USA.
authors.forename: John P
authors.initials: JP
authors.lastname: Sundberg
mesh_terms: D000818:Animals; D003094:Collagen / Q000378:metabolism; D020405:Dermis / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D004548:Elasticity; D004549:Elastin / Q000378:metabolism; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D012867:Skin / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology*; D013045:Species Specificity; D013623:Tail
chemical_list: D003094:Collagen; D004549:Elastin
keywords: Collagen; Elastin fibers; Inbred; Mouse; Skin fragility; Wild-derived