title: Organelle transport during mouse oocyte differentiation in germline cysts.
abstract: During mammalian oogenesis, germ cells undergo oocyte differentiation and oocyte development to form mature oocytes that contain essential components for supporting early embryogenesis. However, only a small fraction of germ cells become mature oocytes and the mechanism of this massive germ cell loss has been unclear. Our recent studies suggested that the formation of functional oocytes and germ cell loss are interlinked by a 'nursing' process in germline cysts during oocyte differentiation in mouse fetal ovaries. 80% of the fetal germ cells sacrifice themselves by donating their cytoplasmic contents to the remaining sister germ cells that differentiate into primary oocytes with augmented developmental potential. In this review, we will summarize the process of mouse oocyte differentiation with a particular focus on organelle transport in germline cysts.
authors.affiliation: Department of Cell and Developmental Biology, University of Michigan Medical School, 109 Zina Pitcher Place, BSRB 3045, Ann Arbor, MI 48109, United States.
authors.forename: Kanako
authors.initials: K
authors.lastname: Ikami
authors.affiliation: Department of Cell and Developmental Biology, University of Michigan Medical School, 109 Zina Pitcher Place, BSRB 3045, Ann Arbor, MI 48109, United States.
authors.forename: Nafisa
authors.initials: N
authors.lastname: Nuzhat
authors.affiliation: Department of Cell and Developmental Biology, University of Michigan Medical School, 109 Zina Pitcher Place, BSRB 3045, Ann Arbor, MI 48109, United States. Electronic address: leile@med.umich.edu.
authors.forename: Lei
authors.initials: L
authors.lastname: Lei
mesh_terms: D000818:Animals; D001692:Biological Transport; D002454:Cell Differentiation; D003593:Cytoplasm / Q000378:metabolism; D005260:Female; D005854:Germ Cells; D051379:Mice; D009865:Oocytes / Q000166:cytology*; D009866:Oogenesis; D015388:Organelles / Q000378:metabolism*