title: Role of lncRNAs in Cellular Aging.
abstract: Aging is a universal, intrinsic, and time-dependent biological decay that is linked to intricate cellular processes including cellular senescence, telomere shortening, stem cell exhaustion, mitochondrial dysfunction, and deregulated metabolism. Cellular senescence is accepted as one of the core processes of aging at the organism level. Understanding the molecular mechanism underlying senescence could facilitate the development of potential therapeutics for aging and age-related diseases. Recently, the discovery of long non-coding RNAs (lncRNA) provided insights into a novel regulatory layer that can intervene with cellular senescence. Increasing evidence indicates that targeting lncRNAs may impact on senescence pathways. In this review, we will focus on lncRNAs involved in mechanistic pathways governing cellular senescence.
authors.affiliation: Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore; Department of Biological Sciences, National University of Singapore, Singapore.
authors.forename: Ufuk
authors.initials: U
authors.lastname: Degirmenci
authors.affiliation: Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore; Programme in Cardiovascular and Metabolic Disorders, Duke-NUS, Singapore.
authors.forename: Sun
authors.initials: S
authors.lastname: Lei
keywords: PRC; SASP; aging; lncRNA; p16; p21; p53; senescence