title: Early Results of Pilot Study Using Hepatitis C Virus (HCV) Positive Kidneys to Transplant HCV Infected Patients with End-Stage Renal Disease Allowing for Successful Interferon-Free Direct Acting Antiviral Therapy after Transplantation.
abstract: BACKGROUND
  Hepatitis C virus (HCV) infection in kidney transplant (KTX) patients reduces long-term patient and graft survival. Direct-acting antivirals (DAA) are > 90% effective in achieving sustained viral response (SVR); however, DAAs are not routinely available to patients with end-stage renal disease (ESRD). The University of Utah Transplant Program developed a protocol to allow HCV-positive potential KTX recipients to accept HCV-positive donors' kidneys. Three months after successful KTX, they were eligible for DAA therapy.
  
  
  METHODS
  HCV-positive patients approved for KTX by the University of Utah Transplant Selection Committee were eligible to be enrolled in this study. Patients consented for the use of HCV-positive donor organs. Three to six months after successful KTX, these patients were treated for HCV with interferon-free direct-acting antiviral regimens according to viral genotype and prior treatment experience.
  
  
  RESULTS
  Between 2014-2015, 12 HCV-positive patients were listed for KTX. Eight patients were kidney only eligible, seven patients received HCV-positive deceased donor kidneys, and one received an HCV-negative organ. Currently, six patients have completed treatment, all have achieved sustained viral response (SVR), and one patient is currently awaiting treatment. All seven patients have functioning kidney grafts. Wait time for KTX was reduced amongst all blood groups from an average of 1,350 days to only 65 days.
  
  
  CONCLUSIONS
  HCV-positive patients with ESRD can successfully receive an HCV-positive donor's kidney. Once transplanted, these patients can receive DAA therapy and achieve SVR. Use of HCV-positive organs reduced time on the waitlist by greater than three years and expanded the donor organ pool.
authors.affiliation: Internal Medicine, Gastroenterology, University of Utah School of Medicine.
authors.forename: Juan F
authors.initials: JF
authors.lastname: Gallegos-Orozco
authors.affiliation: General Surgery, University of Utah School of Medicine.
authors.forename: Robin
authors.initials: R
authors.lastname: Kim
authors.affiliation: Department of Surgery, University of Utah School of Medicine.
authors.forename: Heather F
authors.initials: HF
authors.lastname: Thiesset
authors.affiliation: Internal Medicine, Gastroenterology, University of Utah School of Medicine.
authors.forename: Jenny
authors.initials: J
authors.lastname: Hatch
authors.affiliation: Internal Medicine, Gastroenterology, University of Utah School of Medicine.
authors.forename: Keisa
authors.initials: K
authors.lastname: Lynch
authors.affiliation: Division of Transplantation and Advanced Hepatobiliary Surgery, University of Utah School of Medicine.
authors.forename: Thomas
authors.initials: T
authors.lastname: Chaly
authors.affiliation: Internal Medicine, Nephrology, University of Utah School of Medicine.
authors.forename: Fuad
authors.initials: F
authors.lastname: Shihab
authors.affiliation: Internal Medicine, Nephrology, University of Utah School of Medicine.
authors.forename: Faris
authors.initials: F
authors.lastname: Ahmed
authors.affiliation: Internal Medicine, Nephrology, University of Utah School of Medicine.
authors.forename: Isaac
authors.initials: I
authors.lastname: Hall
authors.affiliation: Division of Transplantation and Advanced Hepatobiliary Surgery, University of Utah School of Medicine.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Campsen
keywords: hepatitis c; transplant