title: Enantioselective Tandem Oxidation/Michael-Aldol Approaches to Tetrasubstituted Cyclohexanes.
abstract: Enantioselective tandem Michael-aldol and oxidative Michael-aldol approaches have been achieved for the formation of diversely substituted cyclohexanes in total regio-, diastereo- and enantioselective fashion. The presence of nitro, hydroxy and keto groups in the product provides a wide scope for further structural transformations. Furthermore, the utility of the catalytic process is demonstrated in the context of enantioselective formal synthesis of ABT-341, a DPP4 inhibitor.
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhopal, M.P.-, 462 066, India.
authors.forename: Nirmal K
authors.initials: NK
authors.lastname: Rana
authors.affiliation: Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur, U.P.-, 208 016, India.
authors.forename: Harshit
authors.initials: H
authors.lastname: Joshi
authors.affiliation: Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur, U.P.-, 208 016, India.
authors.forename: Rupesh K
authors.initials: RK
authors.lastname: Jha
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhopal, M.P.-, 462 066, India.|Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur, U.P.-, 208 016, India.
authors.forename: Vinod K
authors.initials: VK
authors.lastname: Singh
keywords: ABT-341; Michael-aldol; asymmetric synthesis; oxidation; tetrasubstituted cyclohexane