title: Preoperative Acute Inflammatory Markers as Predictors for Postoperative Complications in Primary Total Knee Arthroplasty.
abstract: BACKGROUND
  C-reactive protein (CRP) has been suggested as an independent risk factor for cardiovascular pathology in the nonsurgical setting. While postoperative CRP and erythrocyte sedimentation rate (ESR) have an established role in aiding the diagnosis of periprosthetic joint infections, some authors suggest a link between preoperative CRP and postoperative complications in patients undergoing total joint arthroplasty.
  
  
  METHODS
  We conducted a retrospective cohort study of 351 patients who underwent unilateral primary total knee arthroplasty by a single surgeon during a 28-month period (January 2013 through April 2015). Patient medical records were reviewed for the following complications occurring within 90 days postoperatively: myocardial infarction, arrhythmia, pulmonary embolism, wound infection, acute renal failure, and reoperation.
  
  
  RESULTS
  We found no statistically significant link between postoperative complications and preoperative CRP levels (P=0.5005) or ESR levels (P=0.1610).
  
  
  CONCLUSIONS
  The results of this study do not support the routine inclusion of CRP and ESR analysis as part of the preoperative evaluation for elective total knee arthroplasty.
authors.affiliation: Department of Orthopedic Surgery, Ochsner Clinic Foundation, New Orleans, LA.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Godoy
authors.affiliation: Department of Orthopedic Surgery, Ochsner Clinic Foundation, New Orleans, LA.
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Sumarriva
authors.affiliation: Department of Orthopedic Surgery, Ochsner Clinic Foundation, New Orleans, LA.
authors.forename: J Lockwood
authors.initials: JL
authors.lastname: Ochsner
authors.affiliation: Department of Orthopedic Surgery, Ochsner Clinic Foundation, New Orleans, LA ; The University of Queensland School of Medicine, Ochsner Clinical School, New Orleans, LA.
authors.forename: George
authors.initials: G
authors.lastname: Chimento
authors.affiliation: Department of Infection Control, Ochsner Clinic Foundation, New Orleans, LA.
authors.forename: Dana
authors.initials: D
authors.lastname: Schmucker
authors.affiliation: Department of Orthopedics, Louisiana State University Health Sciences Center, New Orleans, LA.
authors.forename: Vinod
authors.initials: V
authors.lastname: Dasa
authors.affiliation: Department of Orthopedic Surgery, Ochsner Clinic Foundation, New Orleans, LA ; The University of Queensland School of Medicine, Ochsner Clinical School, New Orleans, LA.
authors.forename: Mark
authors.initials: M
authors.lastname: Meyer
keywords: Arthroplasty–replacement–knee; C-reactive protein; blood sedimentation; postoperative complications