title: Titanocenes as anticancer agents: recent insights.
abstract: BACKGROUND
  Enormous success of antitumor agent cisplatin initiated interest in other organometallic complexes. A subclass of organometallic compounds termed metallocenes, characterized by a transition metal central atom (M) bound to cyclopentadienide (Cp-/[C5H5]-) ligands with the basic formula Cp2M, has gained increasing interest as promising anticancer agents.
  
  
  OBJECTIVE
  This review is aimed at a progress in the development of organometallic titanium-based compounds focusing primarily on the evaluation of their cytotoxic activity and mechanism of action in relation to potential utilization as anticancer drugs.
  
  
  RESULTS
  Metallocenes bearing titanium as central atom were sorted according to their structure and modifications and their anticancer activity is further discussed.
  
  
  CONCLUSIONS
  Titanocenes represent family of promising compounds exerting cytostatic activity. We suggest that their application not only as separate agents, but also in combination with newly developed carriers, e.g. nanomaterials, may lead to improvement of their delivery into tumor cells and following utilization in cancer treatment.
authors.forename: Hana
authors.initials: H
authors.lastname: Skoupilova
authors.affiliation: RECAMO, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53, Brno, Czech Republic. Czech Republic.
authors.forename: Roman
authors.initials: R
authors.lastname: Hrstka
authors.forename: Martin
authors.initials: M
authors.lastname: Bartosik