title: Plasma DPP4 activity is associated with no-reflow and major bleeding events in Chinese PCI-treated STEMI patients.
abstract: Dipeptidyl peptidase-4 (DPP4) is an important regulator of incretins and inflammation, and it is involved in the pathophysiological process of myocardial infarction (MI). This study investigated the role of plasma DPP4 activity (DPP4a) in patients with ST-segment elevation myocardial infarction (STEMI) who had undergone percutaneous coronary intervention (PCI). We recruited 747 consecutive PCI-treated STEMI patients from a tertiary referral center from January 2014 to October 2015. The outcomes of interest were the rates of no-reflow, in-hospital major adverse cardiac or cerebrovascular events (iMACCE), in-hospital complications (IHC) and in-hospital major bleeding. The DPP4a was lower in STEMI patients compared with the controls (p < 0.0001). Multivariate logistic-regression analyses (adjusted for confounding variables) showed that a 1 U/L increase in DPP4a was associated with an increased rate of no-reflow events (odds ratio [OR]: 1.07; 95% CI: 1.02-1.11; p < 0.01) and a decreased rate of major bleeding events (OR: 0.90; 95% CI: 0.82-0.98; p = 0.02). There were no associations between DPP4a and either iMACCE or IHC. In conclusions, high levels of DPP4a are independently associated with an increased rate of no-reflow events and a decreased rate of major bleeding events in PCT-treated STEMI patients.
authors.affiliation: Department of Cardiology, People's Liberation Army General Hospital, Beijing, China.|Department of Cardiology, Xinqiao Hospital, Third Military Medical University, Chongqing, China.
authors.forename: Jing Wei
authors.initials: JW
authors.lastname: Li
authors.affiliation: Department of Cardiology, People's Liberation Army General Hospital, Beijing, China.
authors.forename: Yun Dai
authors.initials: YD
authors.lastname: Chen
authors.affiliation: Department of Cardiology, People's Liberation Army General Hospital, Beijing, China.
authors.forename: Wei Ren
authors.initials: WR
authors.lastname: Chen
authors.affiliation: Department of Cardiology, People's Liberation Army General Hospital, Beijing, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Jing
authors.affiliation: Department of Cardiology, People's Liberation Army General Hospital, Beijing, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Cardiology, People's Liberation Army General Hospital, Beijing, China.
authors.forename: Yong Qiang
authors.initials: YQ
authors.lastname: Yang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D003326:Coronary Circulation / Q000502:physiology; D018819:Dipeptidyl Peptidase 4 / Q000097:blood*; D005260:Female; D006470:Hemorrhage / Q000097:blood* / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000601:surgery; D062645:Percutaneous Coronary Intervention / Q000379:methods; D010949:Plasma / Q000378:metabolism*; D012307:Risk Factors; D000072657:ST Elevation Myocardial Infarction / Q000097:blood* / Q000601:surgery; D016896:Treatment Outcome
chemical_list: C042807:DPP4 protein, human; D018819:Dipeptidyl Peptidase 4