title: Clinicopathological Implication of Insulin-like Growth Factor-II mRNA-Binding Protein 3 (IMP3) Expression in Gastric Cancer.
abstract: The clinicopathological significance of oncofetal mRNA-binding protein, human insulin-like growth factor II mRNA-binding protein 3 (IMP3), in gastric carcinoma (GC) is not fully understood.
  
  
  
  Tissue microarray blocks with specimens from 346 patients with GC were constructed to evaluate the clinicopathological role of IMP3 expression in GC. These results were validated with an online dataset of 876 patients from the Kaplan-Meier Plotter. Sera from 15 controls and 57 patients with GC were collected in order to compare the levels of serum IMP3 between groups.
  
  
  
  High expression of IMP3 was significantly associated with poor prognosis. Survival curves from the Kaplan-Meier Plotter showed that high IMP3 expression was significantly related to worse disease-free survival and overall survival.
  
  
  
  Tissue overexpression of IMP3 might be used as a predictor of advanced disease or lymph node metastasis, and is associated with poorer prognosis in GCs.
authors.affiliation: Department of Pathology, Ajou University School of Medicine, Suwon, Republic of Korea.
authors.forename: Dakeun
authors.initials: D
authors.lastname: Lee
authors.affiliation: Department of Pathology, Ajou University School of Medicine, Suwon, Republic of Korea.
authors.forename: Eun Ji
authors.initials: EJ
authors.lastname: Yu
authors.affiliation: Department of Surgery, Ajou University School of Medicine, Suwon, Republic of Korea.|Brain Korea 21 Plus Research Center for Biomedical Science, Ajou University, Suwon, Republic of Korea.
authors.forename: In-Hye
authors.initials: IH
authors.lastname: Ham
authors.affiliation: Department of Surgery, Ajou University School of Medicine, Suwon, Republic of Korea hhcmc75@naver.com hhcmc75@ajou.ac.kr.|Brain Korea 21 Plus Research Center for Biomedical Science, Ajou University, Suwon, Republic of Korea.
authors.forename: Hoon
authors.initials: H
authors.lastname: Hur
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000097:blood; D016022:Case-Control Studies; D016208:Databases, Factual; D018572:Disease-Free Survival; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005743:Gastrectomy; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D016601:RNA-Binding Proteins / Q000032:analysis* / Q000097:blood; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000097:blood / Q000737:chemistry* / Q000401:mortality / Q000601:surgery; D013997:Time Factors; D046888:Tissue Array Analysis; D016896:Treatment Outcome; D015854:Up-Regulation; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; C498780:IGF2BP3 protein, human; D016601:RNA-Binding Proteins
keywords: Gastric cancer; insulin-like growth factor-II mRNA-binding protein 3; prognosis