title: Epicenters of dynamic connectivity in the adaptation of the ventral visual system.
abstract: Neuronal responses adapt to familiar and repeated sensory stimuli. Enhanced synchrony across wide brain systems has been postulated as a potential mechanism for this adaptation phenomenon. Here, we used recently developed graph theory methods to investigate hidden connectivity features of dynamic synchrony changes during a visual repetition paradigm. Particularly, we focused on strength connectivity changes occurring at local and distant brain neighborhoods.
  
  
  
  We found that connectivity reorganization in visual modal cortex-such as local suppressed connectivity in primary visual areas and distant suppressed connectivity in fusiform areas-is accompanied by enhanced local and distant connectivity in higher cognitive processing areas in multimodal and association cortex. Moreover, we found a shift of the dynamic functional connections from primary-visual-fusiform to primary-multimodal/association cortex.
  
  
  
  These findings suggest that repetition-suppression is made possible by reorganization of functional connectivity that enables communication between low- and high-order areas. Hum Brain Mapp 38:1965-1976, 2017. © 2017 Wiley Periodicals, Inc.
authors.affiliation: Center of Neuroimmunology, Institut d'Investigacions Biomedica August Pi Sunyer, Barcelona, Spain.|Gordon Center For Medical Imaging, Department of Radiology, Division of Nuclear Medicine and Molecular Imaging, Harvard Medical School, Boston, Massachusetts.
authors.forename: Vesna
authors.identifier: 0000-0003-4536-2286
authors.initials: V
authors.lastname: Prčkovska
authors.affiliation: Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Boston, Massachusetts.|Department of Population Health Sciences, German Center for Neurodegenerative Diseases, Bonn, Germany.
authors.forename: Willem
authors.initials: W
authors.lastname: Huijbers
authors.affiliation: Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Boston, Massachusetts.
authors.forename: Aaron
authors.initials: A
authors.lastname: Schultz
authors.affiliation: Gordon Center For Medical Imaging, Department of Radiology, Division of Nuclear Medicine and Molecular Imaging, Harvard Medical School, Boston, Massachusetts.
authors.forename: Laura
authors.initials: L
authors.lastname: Ortiz-Teran
authors.affiliation: Gordon Center For Medical Imaging, Department of Radiology, Division of Nuclear Medicine and Molecular Imaging, Harvard Medical School, Boston, Massachusetts.
authors.forename: Cleofe
authors.initials: C
authors.lastname: Peña-Gomez
authors.affiliation: Center of Neuroimmunology, Institut d'Investigacions Biomedica August Pi Sunyer, Barcelona, Spain.|Department of Neurology, University of California, San Francisco, California.
authors.forename: Pablo
authors.initials: P
authors.lastname: Villoslada
authors.affiliation: Gordon Center For Medical Imaging, Department of Radiology, Division of Nuclear Medicine and Molecular Imaging, Harvard Medical School, Boston, Massachusetts.|Department of Neurology, Centre for Alzheimer Research and Treatment, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.|Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
authors.forename: Keith
authors.initials: K
authors.lastname: Johnson
authors.affiliation: Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Boston, Massachusetts.|Department of Neurology, Centre for Alzheimer Research and Treatment, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.|Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
authors.forename: Reisa
authors.initials: R
authors.lastname: Sperling
authors.affiliation: Gordon Center For Medical Imaging, Department of Radiology, Division of Nuclear Medicine and Molecular Imaging, Harvard Medical School, Boston, Massachusetts.|Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Boston, Massachusetts.
authors.forename: Jorge
authors.initials: J
authors.lastname: Sepulcre
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D000293:Adolescent; D000328:Adult; D001931:Brain Mapping; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008959:Models, Neurological; D017711:Nonlinear Dynamics; D010100:Oxygen / Q000097:blood; D010775:Photic Stimulation; D014793:Visual Cortex / Q000000981:diagnostic imaging / Q000502:physiology*; D014795:Visual Pathways / Q000000981:diagnostic imaging / Q000502:physiology*; D055815:Young Adult
chemical_list: D010100:Oxygen
keywords: adaptation; dynamic connectivity; face processing; graph theory; multimodal integration; repetition suppression; visual system