title: Emerging biopharmaceuticals from bioactive peptides derived from marine organisms.
abstract: Biologically active natural products are spontaneous medicinal entrants, which encourage synthetic access for enhancing and supporting drug discovery and development. Marine bioactive peptides are considered as a rich source of natural products that may provide long-term health, in addition to many prophylactic and curative medicinal drug treatments. The large literature concerning marine peptides has been collected, which shows high potential of nutraceutical and therapeutic efficacy encompassing wide spectra of bioactivities against a number of infection-causing agents. Their antimicrobial, antimalarial, antitumor, antiviral, and cardioprotective actions have achieved the attention of the pharmaceutical industry toward new design of drug formulations, for treatment and prevention of several infections. However, the mechanism of action of many peptide molecules has been still untapped. So in this regard, this paper reviews several peptide compounds by which they interfere with human pathogenesis. This knowledge is one of the key tools to be understood especially for the biotransformation of biomolecules into targeted medicines. The fact that different diseases have the capability to fight at different sites inside the body can lead to a new wave of increasing the chances to produce targeted medicines.
authors.affiliation: Ocean College, Zhejiang University, Hangzhou, China.
authors.forename: Komal
authors.initials: K
authors.lastname: Anjum
authors.affiliation: Faculty of Pharmacy, Gomal University, D.I. Khan, Khyber-Pakhtunkhwa, Pakistan.
authors.forename: Syed Qamar
authors.initials: SQ
authors.lastname: Abbas
authors.affiliation: Ocean College, Zhejiang University, Hangzhou, China.
authors.forename: Najeeb
authors.initials: N
authors.lastname: Akhter
authors.affiliation: Department of Zoology, Kohat University of Science and Technology (KUST), D.I. Khan, Khyber-Pakhtunkhwa, Pakistan.
authors.forename: Bibi Ibtesam
authors.initials: BI
authors.lastname: Shagufta
authors.affiliation: Ocean College, Zhejiang University, Hangzhou, China.
authors.forename: Sayed Asmat Ali
authors.initials: SAA
authors.lastname: Shah
authors.affiliation: Ocean College, Zhejiang University, Hangzhou, China.
authors.forename: Syed Shams Ul
authors.identifier: 0000-0001-5188-6540
authors.initials: SSU
authors.lastname: Hassan
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D059001:Aquatic Organisms / Q000378:metabolism*; D032407:Avicennia / Q000378:metabolism; D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000458:Cyanobacteria / Q000378:metabolism; D008870:Microtubules / Q000187:drug effects / Q000378:metabolism; D009369:Neoplasms / Q000188:drug therapy; D010455:Peptides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D011161:Porifera / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D001688:Biological Products; D010455:Peptides
keywords: antimicrobial; antitumor; marine peptides; natural products; novel drugs