title: Posner-Schlossman syndrome.
abstract: Posner-Schlossman syndrome, or glaucomatocyclitic crisis, is a unilateral ocular condition characterized by recurrent attacks of nongranulomatous anterior uveitis and raised intraocular pressure that can result in chronic secondary glaucoma. This relatively rare disease is most likely the result of recurrent cytomegalovirus infection and affects predominantly middle-aged males. Diagnosis is largely clinical, with aqueous and blood sampling aiding the identification of any underlying infectious cause. Successful disease management is often achieved by topical treatment, although systemic therapy and even surgical intervention may be required. We discuss our current understanding of Posner-Schlossman syndrome, from its pathophysiology through to recommended treatment options.
authors.affiliation: Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom; Princess Alexandra Eye Pavilion, Edinburgh, United Kingdom. Electronic address: roly.megaw@ed.ac.uk.
authors.forename: Roly
authors.initials: R
authors.lastname: Megaw
authors.affiliation: Princess Alexandra Eye Pavilion, Edinburgh, United Kingdom.
authors.forename: Pankaj Kumar
authors.initials: PK
authors.lastname: Agarwal
mesh_terms: D019468:Disease Management; D005902:Glaucoma, Open-Angle / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D007429:Intraocular Pressure; D015863:Iridocyclitis / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D013577:Syndrome
keywords: Posner-Schlossman; cytomegalovirus; glaucoma; glaucomacyclitic crisis; iridocyclitis; uveitis