title: Clinicopathologic and prognostic factors in adenoid cystic carcinoma of head and neck minor salivary glands: A clinical analysis of 130 cases.
abstract: OBJECTIVE
  This study was to investigate clinicopathologic characteristics and prognostic factors in adenoid cystic carcinoma of head and neck minor salivary glands.
  
  
  METHODS
  We conducted a retrospective review of 130 patients with adenoid cystic carcinoma of head and neck minor salivary glands that were evaluated between 2000 and 2013 in Beijng Tongren Hospital.
  
  
  RESULTS
  Five-year overall survival and disease-free survival rates were 80.8% and 55.6%. Local recurrence rate was 40%, regional recurrence 3.8%, and distant metastasis was 28.5%. On univariate analysis, solid histological subtype, perineural invasion, positive surgical margins and advanced stages were found to be poor prognostic indicators. On multivariate analysis, solid histological subtype and positive surgical margins were significant prognostic factors of worse overall survival.
  
  
  CONCLUSIONS
  Solid histological subtype and positive surgical margins were the most important predictors of poor outcome in adenoid cystic carcinoma of minor salivary glands. Surgery with postoperative radiation were recommended treatment and offered durable local control.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Key Laboratory of Otolaryngology-Head and Neck Surgery, Ministry of Education, Capital Medical University, No.1, Dongjiaominxiang Street, Dongcheng District, Beijing 100730, PR China.
authors.forename: Shizhi
authors.initials: S
authors.lastname: He
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Key Laboratory of Otolaryngology-Head and Neck Surgery, Ministry of Education, Capital Medical University, No.1, Dongjiaominxiang Street, Dongcheng District, Beijing 100730, PR China.
authors.forename: Pingdong
authors.initials: P
authors.lastname: Li
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Key Laboratory of Otolaryngology-Head and Neck Surgery, Ministry of Education, Capital Medical University, No.1, Dongjiaominxiang Street, Dongcheng District, Beijing 100730, PR China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhong
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Key Laboratory of Otolaryngology-Head and Neck Surgery, Ministry of Education, Capital Medical University, No.1, Dongjiaominxiang Street, Dongcheng District, Beijing 100730, PR China.
authors.forename: Lizhen
authors.initials: L
authors.lastname: Hou
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Nanjing Tongren Hospital, Jiyin Road 2007, Nanjing, Jiangsu Province 211102, PR China.
authors.forename: Zhenkun
authors.initials: Z
authors.lastname: Yu
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Key Laboratory of Otolaryngology-Head and Neck Surgery, Ministry of Education, Capital Medical University, No.1, Dongjiaominxiang Street, Dongcheng District, Beijing 100730, PR China.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Huang
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Key Laboratory of Otolaryngology-Head and Neck Surgery, Ministry of Education, Capital Medical University, No.1, Dongjiaominxiang Street, Dongcheng District, Beijing 100730, PR China.
authors.forename: Xuejun
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Key Laboratory of Otolaryngology-Head and Neck Surgery, Ministry of Education, Capital Medical University, No.1, Dongjiaominxiang Street, Dongcheng District, Beijing 100730, PR China.
authors.forename: Jugao
authors.initials: J
authors.lastname: Fang
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Key Laboratory of Otolaryngology-Head and Neck Surgery, Ministry of Education, Capital Medical University, No.1, Dongjiaominxiang Street, Dongcheng District, Beijing 100730, PR China. Electronic address: trchxh@163.com.
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003528:Carcinoma, Adenoid Cystic / Q000473:pathology* / Q000601:surgery*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D000072662:Margins of Excision; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D011379:Prognosis; D012468:Salivary Gland Neoplasms / Q000473:pathology* / Q000601:surgery*; D012470:Salivary Glands, Minor / Q000473:pathology* / Q000601:surgery*; D015996:Survival Rate
keywords: Adenoid cystic carcinoma; Head and neck neoplasms; Minor salivary glands; Prognostic factors; Therapeutic modality