title: Post-pregnancy aspirin resistance appears not to be related with recurrent hypertensive disorders of pregnancy.
abstract: OBJECTIVE
  The FRUIT-RCT concluded that low-molecular-weight heparin added to aspirin compared to treatment with aspirin alone is beneficial in the prevention of early-onset hypertensive disorders of pregnancy (HD) in women with inheritable thrombophilia and prior HD and/or a small-for-gestational age (SGA) infant leading to delivery before 34 weeks gestation. The aim of this study is to answer the question whether aspirin resistance is associated with recurrent HD.
  
  
  METHODS
  Women with and without recurrent HD matched for age, study arm, and chronic hypertension were invited for this follow-up study 6-16 years after they participated in the FRUIT-RCT. Aspirin resistance was tested after 10days of aspirin intake using three complementary tests: PFA-200, VerifyNow®and serum thromboxane B2(TXB2). An independent t-test, Mann-Whitney U test, Fisher's Exact test and Chi2test were used for the statistical analyses.
  
  
  RESULTS
  Thirteen of 24 women with recurrent HD and 16 of 24 women without recurrent HD participated. The prevalence of laboratory aspirin resistance was 34.5% according to the PFA-200, 3.4% according to the VerifyNow®and 24.1% according to TXB2. The prevalence of aspirin resistance by any test was 51.7%. Aspirin resistance per individual test did not differ between women with and without recurrent HD. Aspirin resistance measured by any test occurred more frequently in women without recurrent HD (p<0.01), irrespective of low-molecular-weight heparin.
  
  
  CONCLUSIONS
  No relation could be demonstrated between recurrent HD and aspirin resistance per test, measured up to 16 years after pregnancy. On the contrary, complementary aspirin resistance measurements were encountered more frequently in women without recurrent HD.
authors.affiliation: Department of Obstetrics and Gynecology, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands. Electronic address: c.abheiden@vumc.nl.
authors.forename: Carolien N H
authors.initials: CNH
authors.lastname: Abheiden
authors.affiliation: Department of Internal Medicine, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands.
authors.forename: Wessel W
authors.initials: WW
authors.lastname: Fuijkschot
authors.affiliation: Department of Obstetrics and Gynecology, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands.
authors.forename: Arda
authors.initials: A
authors.lastname: Arduç
authors.affiliation: Department of Internal Medicine, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands.
authors.forename: Jeske J K
authors.initials: JJK
authors.lastname: van Diemen
authors.affiliation: Department of Clinical Pharmacology and Pharmacy, VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands.
authors.forename: Ankie M
authors.initials: AM
authors.lastname: Harmsze
authors.affiliation: Department of Obstetrics and Gynecology, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands.
authors.forename: Marjon A
authors.initials: MA
authors.lastname: de Boer
authors.affiliation: Department of Internal Medicine, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands.
authors.forename: Abel
authors.initials: A
authors.lastname: Thijs
authors.affiliation: Department of Obstetrics and Gynecology, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands.
authors.forename: Johanna I P
authors.initials: JIP
authors.lastname: de Vries
mesh_terms: D000328:Adult; D001241:Aspirin; D004351:Drug Resistance; D005260:Female; D005343:Fibrinolytic Agents; D005500:Follow-Up Studies; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000209:etiology*; D008875:Middle Aged; D011247:Pregnancy
chemical_list: D005343:Fibrinolytic Agents; D001241:Aspirin
keywords: Aspirin; Aspirin resistance; Hypertensive disorders of pregnancy; Low-molecular-weight heparin; Preeclampsia