title: Size-dependent lymphatic uptake of nanoscale-tailored particles as tumor mass increases.
abstract: OBJECTIVE
  To investigate the size-dependent lymphatic uptake of nanoparticles in mice with rapidly growing syngeneic tumors.
  
  
  METHODS
  Mice were inoculated subcutaneously with EL4 lymphoma cells and on day 5 or day 6 of tumor growth, injected peritumorally with either 29 nm or 58 nm of ultra-small superparamagnetic iron oxide nanoparticles. Twenty-four hours later the animals were imaged using MRI.
  
  
  CONCLUSIONS
  The larger of the two particles can only be detected in the lymph node when injected in animals with 6-day-old tumors while the 29 nm ultra-small superparamagnetic iron oxide nanoparticle is observed on both time points. Tumor mass greatly impacts the size of particles that are transported to the lymph nodes.
authors.affiliation: Medical Radiation Physics, Department of Clinical Sciences, Lund University, Barngatan 2:1, SE-22185, Lund, Sweden; GeccoDots AB, Lund, Sweden; Medical Radiation Physics, Department of Clinical Sciences, Lund University, Barngatan 2:1, SE-22185, Lund, Sweden; GeccoDots AB, Lund, Sweden.
authors.forename: Pontus
authors.initials: P
authors.lastname: Kjellman
authors.affiliation: GeccoDots AB, Lund, Sweden; GeccoDots AB, Lund, Sweden.
authors.forename: Sarah
authors.initials: S
authors.lastname: Fredriksson
authors.affiliation: Hansa Medical AB, Lund, Sweden; Hansa Medical AB, Lund, Sweden.
authors.forename: Christian
authors.initials: C
authors.lastname: Kjellman
authors.affiliation: Medical Radiation Physics, Department of Clinical Sciences, Lund University, Barngatan 2:1, SE-22185, Lund, Sweden; Lund University Bioimaging Center, Lund University, Lund, Sweden; Medical Radiation Physics, Department of Clinical Sciences, Lund University, Barngatan 2:1, SE-22185, Lund, Sweden; Lund University Bioimaging Center, Lund University, Lund, Sweden.
authors.forename: Sven-Erik
authors.initials: SE
authors.lastname: Strand
authors.affiliation: GeccoDots AB, Lund, Sweden; Lund University Bioimaging Center, Lund University, Lund, Sweden; GeccoDots AB, Lund, Sweden; Lund University Bioimaging Center, Lund University, Lund, Sweden.
authors.forename: René In 't
authors.initials: RI
authors.lastname: Zandt
keywords: EL4-tumor; MRI; multimodal nanoparticles; sentinel lymph node