title: A cluster of coxsackievirus A21 associated acute respiratory illness: the evidence of efficient transmission of CVA21.
abstract: In March 2016, a cluster of unexplained respiratory illnesses was reported by the acute respiratory infections (ARI) surveillance system of Guangdong Province, China. Twenty-three high school students and one teacher from the four neighboring classes were admitted to a hospital. CVA21 was found in eight of fourteen patients. Phylogenetic analysis suggested that the CVA21 outbreak was most likely caused by transmission of the virus from person to person. This is the first report of an ARI outbreak caused by CVA21, which suggests that CVA21 has the potential to be transmitted efficiently from person to person and should be closely monitored by clinicians and public health agencies.
authors.affiliation: Guangdong Provincial Centre for Disease Control and Prevention, Guangdong, 514300, China.
authors.forename: Lirong
authors.initials: L
authors.lastname: Zou
authors.affiliation: Guangdong Provincial Centre for Disease Control and Prevention, Guangdong, 514300, China.|Guangdong Provincial Institutes of Public Health, Guangdong Provincial Centre for Disease Control and Prevention, Guangdong, 514300, China.
authors.forename: Lina
authors.initials: L
authors.lastname: Yi
authors.affiliation: Guangdong Provincial Centre for Disease Control and Prevention, Guangdong, 514300, China.
authors.forename: Yingchao
authors.initials: Y
authors.lastname: Song
authors.affiliation: Guangdong Provincial Centre for Disease Control and Prevention, Guangdong, 514300, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Guangdong Provincial Centre for Disease Control and Prevention, Guangdong, 514300, China.
authors.forename: Lijun
authors.initials: L
authors.lastname: Liang
authors.affiliation: Guangdong Provincial Centre for Disease Control and Prevention, Guangdong, 514300, China.
authors.forename: Hanzhong
authors.initials: H
authors.lastname: Ni
authors.affiliation: Guangdong Provincial Centre for Disease Control and Prevention, Guangdong, 514300, China.
authors.forename: Changwen
authors.initials: C
authors.lastname: Ke
authors.affiliation: Guangdong Provincial Centre for Disease Control and Prevention, Guangdong, 514300, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Wu
authors.affiliation: Guangdong Provincial Centre for Disease Control and Prevention, Guangdong, 514300, China. Jimlu0331@163.com.|Guangdong Provincial Institutes of Public Health, Guangdong Provincial Centre for Disease Control and Prevention, Guangdong, 514300, China. Jimlu0331@163.com.
authors.forename: Jing
authors.initials: J
authors.lastname: Lu
mesh_terms: D000208:Acute Disease; D002681:China / Q000453:epidemiology; D003384:Coxsackievirus Infections / Q000453:epidemiology / Q000635:transmission / Q000821:virology*; D004196:Disease Outbreaks; D030015:Enterovirus C, Human / Q000145:classification / Q000235:genetics / Q000302:isolation & purification* / Q000502:physiology; D006801:Humans; D010802:Phylogeny; D012141:Respiratory Tract Infections / Q000453:epidemiology / Q000635:transmission / Q000821:virology*