title: Auditory changes in acromegaly.
abstract: OBJECTIVE
  The aim of this study is to determine the changes involving auditory system in cases with acromegaly.
  
  
  METHODS
  Otological examinations of 41 cases with acromegaly (uncontrolled n = 22, controlled n = 19) were compared with those of age and gender-matched 24 healthy subjects. Whereas the cases with acromegaly underwent examination with pure tone audiometry (PTA), speech audiometry for speech discrimination (SD), tympanometry, stapedius reflex evaluation and otoacoustic emission tests, the control group did only have otological examination and PTA. Additionally, previously performed paranasal sinus-computed tomography of all cases with acromegaly and control subjects were obtained to measure the length of internal acoustic canal (IAC).
  
  
  RESULTS
  PTA values were higher (p < 0.001 for right ears and p = 0.001 for left ears), and SD scores were (p = 0.002 for right ears and p = 0.002 for left ears) lower in acromegalic patients. IAC width in acromegaly group was narrower compared to that in control group (p = 0.03 for right ears and p = 0.02 for left ears). When only cases with acromegaly were taken into consideration, PTA values in left ears had positive correlation with growth hormone and insulin-like growth factor-1 levels (r = 0.4, p = 0.02 and r = 0.3, p = 0.03). Of all cases with acromegaly 13 (32%) had hearing loss in at least one ear, 7 (54%) had sensorineural type and 6 (46%) had conductive type hearing loss.
  
  
  CONCLUSIONS
  Acromegaly may cause certain changes in the auditory system in cases with acromegaly. The changes in the auditory system may be multifactorial causing both conductive and sensorioneural defects.
authors.affiliation: Division of Endocrinology and Diabetes, Department of Internal Medicine, Gaziantep University Medical Faculty, Gaziantep, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Tabur
authors.affiliation: Division of Endocrinology and Diabetes, Department of Internal Medicine, Endocrinology and Metabolic Disease, Edirne State Hospital, 22030, Edirne, Turkey. drhkorkmaz@yahoo.com.tr.
authors.forename: H
authors.initials: H
authors.lastname: Korkmaz
authors.affiliation: Department of Otorhinolaryngology, Inonu University Medical Faculty, Malatya, Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Baysal
authors.affiliation: Division of Endocrinology and Diabetes, Department of Internal Medicine, Biruni University, Istanbul, Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Hatipoglu
authors.affiliation: Department of Otorhinolaryngology, Mardin Midyat State Hospital, Mardin, Turkey.
authors.forename: I
authors.initials: I
authors.lastname: Aytac
authors.affiliation: Division of Endocrinology and Diabetes, Department of Internal Medicine, Gaziantep University Medical Faculty, Gaziantep, Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Akarsu
mesh_terms: D000172:Acromegaly / Q000150:complications*; D000328:Adult; D001301:Audiometry, Pure-Tone; D016022:Case-Control Studies; D005260:Female; D034381:Hearing Loss / Q000175:diagnosis* / Q000209:etiology* / Q000378:metabolism; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011379:Prognosis
chemical_list: C583557:IGF1 protein, human; D007334:Insulin-Like Growth Factor I
keywords: Acromegaly; Auditory; Hearing