title: Comparison of lung damage in mice exposed to black carbon particles and 1,4-naphthoquinone coated black carbon particles.
abstract: Black carbon (BC) is a key component of atmospheric particles and has a significant effect on human health. BC can provide reactive sites and surfaces thus absorb quinones which were primarily generated from fossil fuel combustion and/or atmospheric photochemical conversions of PAHs. Oxidation could change the characteristics of BC and increase its toxicity. The comparison of lung damage in mice exposed to BC and 1,4-NQ-coated BC (1,4NQ-BC) particles is investigated in this study. Mice which were intratracheally instilled with particles have a higher expression of IL-1β, IL-6 and IL-33 in bronchoalveolar lavage fluid (BALF). Also, the IL-6, IL-33 mRNA expression in the lung tissue of mice instilled with 1,4NQ-BC were higher than that of mice instilled with BC. The pathology results showed that the lung tissue of mice instilled with 1,4NQ-BC particles have much more inflammatory cells infiltration than that of mice treated with BC. It is believed that the MAPK and PI3K-AKT pathway might be involved in the 1,4NQ-BC particles caused lung damage. Results indicated that 1,4NQ-BC particles in the atmosphere may cause more damage to health.
authors.affiliation: Department of Toxicology, School of Public Health, Peking University, Beijing, 100191, PR China; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Beijing, 100191, PR China.
authors.forename: Hongqian
authors.initials: H
authors.lastname: Chu
authors.affiliation: State Key Joint Laboratory of Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering, Peking University, Beijing 100871, PR China.
authors.forename: Jing
authors.initials: J
authors.lastname: Shang
authors.affiliation: Department of Toxicology, School of Public Health, Peking University, Beijing, 100191, PR China; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Beijing, 100191, PR China.
authors.forename: Ming
authors.initials: M
authors.lastname: Jin
authors.affiliation: State Key Joint Laboratory of Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering, Peking University, Beijing 100871, PR China.
authors.forename: Yueyue
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Toxicology, School of Public Health, Peking University, Beijing, 100191, PR China; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Beijing, 100191, PR China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Pan
authors.affiliation: Department of Toxicology, School of Public Health, Peking University, Beijing, 100191, PR China; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Beijing, 100191, PR China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Toxicology, School of Public Health, Peking University, Beijing, 100191, PR China; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Beijing, 100191, PR China.
authors.forename: Xi
authors.initials: X
authors.lastname: Tao
authors.affiliation: Department of Toxicology, School of Public Health, Peking University, Beijing, 100191, PR China; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Beijing, 100191, PR China.
authors.forename: Zhiyuan
authors.initials: Z
authors.lastname: Cheng
authors.affiliation: Department of Toxicology, School of Public Health, Peking University, Beijing, 100191, PR China; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Beijing, 100191, PR China.
authors.forename: Qinghe
authors.initials: Q
authors.lastname: Meng
authors.affiliation: State Key Joint Laboratory of Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering, Peking University, Beijing 100871, PR China; POTEN Environment Group Co., Ltd., Beijing 100082, PR China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, PR China.
authors.forename: Guang
authors.initials: G
authors.lastname: Jia
authors.affiliation: State Key Joint Laboratory of Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering, Peking University, Beijing 100871, PR China.
authors.forename: Tong
authors.initials: T
authors.lastname: Zhu
authors.affiliation: Department of Toxicology, School of Public Health, Peking University, Beijing, 100191, PR China; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Beijing, 100191, PR China. Electronic address: whao@bjmu.edu.cn.
authors.forename: Weidong
authors.initials: W
authors.lastname: Hao
authors.affiliation: Department of Toxicology, School of Public Health, Peking University, Beijing, 100191, PR China; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Beijing, 100191, PR China. Electronic address: weixt1010@gmail.com.
authors.forename: Xuetao
authors.initials: X
authors.lastname: Wei
mesh_terms: D000393:Air Pollutants / Q000009:adverse effects*; D000818:Animals; D001992:Bronchoalveolar Lavage Fluid; D002244:Carbon / Q000009:adverse effects*; D007249:Inflammation; D007378:Interleukins / Q000032:analysis; D008168:Lung / Q000187:drug effects / Q000473:pathology*; D051379:Mice; D009285:Naphthoquinones / Q000009:adverse effects*; D019869:Phosphatidylinositol 3-Kinases; D053260:Soot / Q000009:adverse effects*
chemical_list: D000393:Air Pollutants; D007378:Interleukins; D009285:Naphthoquinones; D053260:Soot; D002244:Carbon; D019869:Phosphatidylinositol 3-Kinases; C035342:1,4-naphthoquinone
keywords: 1,4NQ-BC; Black carbon; IL-33; Lung