title: Non-Deprotonative Primary and Secondary Amination of (Hetero)Arylmetals.
abstract: Herein we disclose a novel method for the facile transfer of primary (-NH2) and secondary amino groups (-NHR) to heteroaryl- as well as arylcuprates at low temperature without the need for precious metal catalysts, ligands, excess reagents, protecting and/or directing groups. This one-pot transformation allows unprecedented functional group tolerance and it is well-suited for the amination of electron-rich, electron-deficient as well as structurally complex (hetero)arylmetals. In some of the cases, only catalytic amounts of a copper(I) salt is required.
authors.affiliation: Department of Chemistry, Rice University , BioScience Research Collaborative, 6500 Main Street, Rm 380, Houston, Texas 77030, United States.
authors.forename: Zhe
authors.identifier: 0000-0003-1194-4026
authors.initials: Z
authors.lastname: Zhou
authors.affiliation: Department of Chemistry, Rice University , BioScience Research Collaborative, 6500 Main Street, Rm 380, Houston, Texas 77030, United States.
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Ma
authors.affiliation: Department of Chemistry, Rice University , BioScience Research Collaborative, 6500 Main Street, Rm 380, Houston, Texas 77030, United States.
authors.forename: Nicole Erin
authors.initials: NE
authors.lastname: Behnke
authors.affiliation: Department of Chemistry, Rice University , BioScience Research Collaborative, 6500 Main Street, Rm 380, Houston, Texas 77030, United States.
authors.forename: Hongyin
authors.initials: H
authors.lastname: Gao
authors.affiliation: Department of Chemistry, Rice University , BioScience Research Collaborative, 6500 Main Street, Rm 380, Houston, Texas 77030, United States.
authors.forename: László
authors.identifier: 0000-0002-3412-5894
authors.initials: L
authors.lastname: Kürti
mesh_terms: D000586:Amination; D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D003300:Copper / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*
chemical_list: D000588:Amines; D009942:Organometallic Compounds; D003300:Copper