title: Low-Molecular-Weight Heparin for the Prevention of Placenta-mediated Pregnancy Complications.
abstract: During the past decade, prophylactic doses of low-molecular-weight heparin (LMWH) have been suggested to decrease the risk of placental-mediated complications. Herein, we review the prospective randomized trials that addressed the usefulness of LMWH in preventing placental-mediated complications in high-risk women. Inclusion criteria and results of these trials are heterogeneous. Unlike older trials (3 of 4 are single center), recent trials (all are multicenter) do not show beneficial effect of LMWH. There is certainly a need of complementary research before stating on the usefulness of LMWH in the prevention of placenta-mediated pregnancy complications in women at high risk.
authors.affiliation: *Department of Obstetrics, Gynecology, and Reproductive Medicine, University Paris Est Créteil, CRC Centre Hospitalier Intercommunal de Créteil, Créteil, France †Department of Obstetrics and Gynecology, Maternal-Fetal Medicine Division, McGovern Medical School at UT Health, Houston, Texas.
authors.forename: Bassam
authors.initials: B
authors.lastname: Haddad
authors.forename: Edouard
authors.initials: E
authors.lastname: Lecarpentier
authors.forename: Cyril
authors.initials: C
authors.lastname: Touboul
authors.forename: Baha M
authors.initials: BM
authors.lastname: Sibai
mesh_terms: D000925:Anticoagulants / Q000008:administration & dosage*; D005260:Female; D006495:Heparin, Low-Molecular-Weight / Q000008:administration & dosage*; D006801:Humans; D010920:Placenta; D010922:Placenta Diseases / Q000517:prevention & control*; D011225:Pre-Eclampsia / Q000517:prevention & control*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000517:prevention & control*; D016032:Randomized Controlled Trials as Topic
chemical_list: D000925:Anticoagulants; D006495:Heparin, Low-Molecular-Weight