title: Real world epidemiology of myeloproliferative neoplasms: a population based study in Korea 2004-2013.
abstract: Myeloproliferative neoplasms (MPNs), with an expected increment in number, impose substantial economic and social burdens. To this end, we conducted a nationwide population-based descriptive epidemiology study. We also investigated medical cost associated with MPNs. Prevalence was the highest for essential thrombocythemia (ET) (range 4.1-9.0 per 100,000), followed by polycythemia vera (PV) (range 2.8-5.4 per 100,000) and primary myelofibrosis (PMF) (range 0.5-0.9 per 100,000). ET incurred the highest cumulative total cost at US$35 million and the most frequent hospital visits, while PMF incurred the highest average cost per person at US$5000. The mean hemoglobin level was 16.9 ± 2.2 g/dL for PV males and 15.5 ± 2.7 g/dL for PV females. Further analyses on hemoglobin levels showed the true positive rate of PV from the significantly elevated hemoglobin group (defined as >18.5 g/dL for men and >16.5 g/dL for women) was 3.01% and that of MPNs was 3.1%. Here, we provide the biggest population-based report on MPN epidemiology that can readily be used as a representative Asian data.
authors.affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
authors.forename: Ja Min
authors.initials: JM
authors.lastname: Byun
authors.affiliation: Department of Laboratory Medicine, Kyung Hee University School of Medicine, 23, Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, Republic of Korea.
authors.forename: Young Jin
authors.initials: YJ
authors.lastname: Kim
authors.affiliation: Research Institute, National Health Insurance Service Ilsan Hospital, Seoul, Republic of Korea.
authors.forename: Taemi
authors.initials: T
authors.lastname: Youk
authors.affiliation: Yangpyeong Public Health Center, Yangpyeong, Republic of Korea.
authors.forename: John Jeongseok
authors.initials: JJ
authors.lastname: Yang
authors.affiliation: Department of Laboratory Medicine, National Health Insurance Service Ilsan Hospital, 100, Ilsan-ro, Ilsandong-gu, Goyang, 10444, Republic of Korea. jhyooken@gmail.com.
authors.forename: Jongha
authors.initials: J
authors.lastname: Yoo
authors.affiliation: Department of Laboratory Medicine, Kyung Hee University School of Medicine, 23, Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, Republic of Korea. 153jesus@hanmail.net.
authors.forename: Tae Sung
authors.initials: TS
authors.lastname: Park
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009196:Myeloproliferative Disorders / Q000175:diagnosis* / Q000453:epidemiology*; D011159:Population Surveillance / Q000379:methods; D015995:Prevalence; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies
keywords: Asia; Epidemiology; Medical cost; Myeloproliferative neoplasm