title: A Rare Case of Hemophagocytic Lymphohistiocytosis Associated with Parvovirus B19 Infection.
abstract: Hemophagocytic lymphohistiocytosis (HLH) is a rare but life-threatening syndrome resulting from excessive immune activation. Secondarily, HLH is often associated with autoimmune disease, infection, and malignancy. The most common infectious trigger is Epstein-Barr virus (EBV) infection. HLH is rarely triggered by parvovirus B19. We discuss a case of a 62-year-old male who presented with multi-organ failure with presumed septic shock who eventually was diagnosed with HLH, with positive parvovirus B19 deoxyribonucleic acid (DNA) polymerase chain reaction (PCR). Prompt treatment with dexamethasone resulted in significant clinical resolution.
authors.affiliation: Internal Medicine Residency, Florida Hospital-Orlando.
authors.forename: Cai
authors.initials: C
authors.lastname: Yuan
authors.affiliation: Internal Medicine Residency, Florida Hospital-Orlando.
authors.forename: Fnu
authors.initials: F
authors.lastname: Asad-Ur-Rahman
authors.affiliation: Graduate Medical Education, Florida Hospital-Orlando.
authors.forename: Khalid
authors.initials: K
authors.lastname: Abusaada
keywords: hemophagocytic lymphohistiocytosis; multi-organ failure; parvovirus b 19