title: Does complement Factor H-Related protein 5 Nephropathy (Troodos Nephropathy) protect from rickettsial infections?
abstract: Complement Factor H-Related protein 5 Nephropathy (CFHR5N) is an endemic hereditary renal disease in the island of Cyprus. Although only very recently recognized, it has provided insight into previously unknown genetic aspects of complement-mediated renal diseases and in fact it has contributed to the introduction of the new disease classification, 'C3 Glomerulopathy'. Herein, based on evidence from epidemiological, genetic, clinical and basic research studies, the hypothesis that CFHR5N could be protective from rickettsial infections is proposed. Confirming this hypothesis, could have significant implications for the study of Complement Factor- H Related Proteins (CFHRs) in renal diseases and rickettsial molecular microbiology.
authors.affiliation: Department of Nephrology, Nicosia General Hospital, Nicosia-Limassol Old Road, No 215, 2049 Nicosia, Cyprus. Electronic address: kousiosa@yahoo.gr.
authors.forename: Andreas
authors.initials: A
authors.lastname: Kousios
mesh_terms: D000818:Animals; D003176:Complement C3 / Q000378:metabolism*; D017242:Complement Factor H / Q000378:metabolism*; D003165:Complement System Proteins / Q000378:metabolism; D003535:Cyprus; D018450:Disease Progression; D005091:Exons; D005828:Genetics, Population; D006579:Heterozygote; D006801:Humans; D007674:Kidney Diseases / Q000378:metabolism*; D008962:Models, Theoretical; D009154:Mutation; D012281:Rickettsia / Q000378:metabolism; D012282:Rickettsia Infections / Q000378:metabolism*
chemical_list: C432223:CFHR5 protein, human; D003176:Complement C3; D017242:Complement Factor H; D003165:Complement System Proteins