title: Sinonasal adenocarcinoma: clinical outcomes and predictive factors.
abstract: A retrospective study of 39 patients treated for sinonasal adenocarcinoma between 1995 and 2010 was performed. Epidemiological, clinical, histological, and therapeutic aspects of this series of patients were analyzed statistically and their impact in terms of overall and disease-free survival established using the Kaplan-Meier method. A search for prognostic factors was made using a log-rank test. The male to female sex ratio was 6.8 to 1. The average age at diagnosis was 65.7 years (range 40.2-85.6 years). An occupational risk factor (wood dust, leather) was found for 19 patients (48.7%). The median patient follow-up was 51.9 months (range 8-180 months). Tumours were classified as T1 in 20.5%, T2 in 25.6%, T3 in 23.1%, and T4 in 30.8% of cases. Disease-free survival rates at 1, 5, and 10 years were 87.9%, 44.8%, and 39.2%, respectively; overall survival rates were 86.1%, 72.2%, and 50.3%, respectively. Overall survival was correlated with tumour status (TNM, American Joint Committee on Cancer) (P=0.004). Surgery followed by radiotherapy improved overall survival (P=0.012) and disease-free survival (P=0.028) when compared to other treatment modalities. When compared to surgery alone, surgery followed by radiotherapy improved disease-free survival regardless of tumour stage (P=0.049).
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Aix-Marseille University, La Conception University Hospital Centre, Marseille, France. Electronic address: justin.michel@ap-hm.fr.
authors.forename: J
authors.initials: J
authors.lastname: Michel
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Aix-Marseille University, La Conception University Hospital Centre, Marseille, France.
authors.forename: T
authors.initials: T
authors.lastname: Radulesco
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Aix-Marseille University, La Conception University Hospital Centre, Marseille, France.
authors.forename: M
authors.initials: M
authors.lastname: Penicaud
authors.affiliation: Department of Public Health and Medical Information, Aix-Marseille University, La Timone University Hospital Centre, Marseille, France.
authors.forename: J
authors.initials: J
authors.lastname: Mancini
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Aix-Marseille University, La Conception University Hospital Centre, Marseille, France.
authors.forename: P
authors.initials: P
authors.lastname: Dessi
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010255:Paranasal Sinus Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate
keywords: radiotherapy; sinus carcinoma; surgery