title: Evaluation of peripheral fundus autofluorescence in eyes with wet age-related macular degeneration.
abstract: OBJECTIVE
  We aimed to evaluate the prevalence of abnormal peripheral fundus autofluorescence (FAF) in wet age-related macular degeneration (AMD) using wide-field imaging instrument.
  
  
  METHODS
  A retrospective, case-controlled study involving 66 eyes of 46 Japanese wet AMD patients and 32 eyes of 20 control patients was performed. Wide-field FAF images were obtained for typical AMD (37 eyes/28 patients), polypoidal choroidal vasculopathy (PCV) (22 eyes/20 patients), and retinal angiomatous proliferation (RAP) (seven eyes/four patients). Two masked ophthalmologists independently graded the images for mottled, granular, and nummular patterns. Main outcome measures were abnormal peripheral FAF frequencies and relative risks by disease subgroups and treatments.
  
  
  RESULTS
  Abnormal peripheral FAF patterns were found in 51.5% of wet AMD eyes compared with 18.8% of control eyes (P<0.001). Mottled, granular, and nummular patterns were found in 45.5%, 31.8%, and 16.7%, respectively, of wet AMD eyes. Each disease subgroup (typical AMD, 54.1%; PCV, 36.4%; and RAP, 85.7%) showed significantly higher frequencies of peripheral FAF (P<0.001,P=0.03, andP<0.001, respectively) than control eyes (18.8%). There were no significant differences (P=0.76) between the frequencies in untreated and treated eyes.
  
  
  CONCLUSIONS
  Eyes of Japanese wet AMD patients had a higher abnormal FAF prevalence compared with control eyes. Among the three disease subtypes, abnormal patterns were least prevalent in PCV eyes.
authors.affiliation: Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences; Department of Ophthalmology, General Kamiiida Daiichi Hospital.
authors.forename: Tetsuyuki
authors.initials: T
authors.lastname: Suetsugu
authors.affiliation: Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences.
authors.forename: Aki
authors.initials: A
authors.lastname: Kato
authors.affiliation: Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences.
authors.forename: Munenori
authors.initials: M
authors.lastname: Yoshida
authors.affiliation: Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Yasukawa
authors.affiliation: Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences; Nishiwaki Eye Clinic, Nagoya, Aichi, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Nishiwaki
authors.affiliation: Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences.
authors.forename: Norio
authors.initials: N
authors.lastname: Hasegawa
authors.affiliation: Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Usui
authors.affiliation: Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences.
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Ogura
keywords: age-related macular degeneration; fundus autofluorescence; polypoidal choroidal vasculopathy; retinal angiomatous proliferation