title: Clinical Pharmacogenetic Testing and Application: Laboratory Medicine Clinical Practice Guidelines.
abstract: Pharmacogenetic testing for clinical applications is steadily increasing. Correct and adequate use of pharmacogenetic tests is important to reduce unnecessary medical costs and adverse patient outcomes. This document contains recommended pharmacogenetic testing guidelines for clinical application, interpretation, and result reporting through a literature review and evidence-based expert opinions for the clinical pharmacogenetic testing covered by public medical insurance in Korea. This document aims to improve the utility of pharmacogenetic testing in routine clinical settings.
authors.affiliation: Department of Laboratory Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.
authors.forename: Sollip
authors.initials: S
authors.lastname: Kim
authors.affiliation: Department of Laboratory Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.
authors.forename: Yeo Min
authors.initials: YM
authors.lastname: Yun
authors.affiliation: Department of Laboratory Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Hyo Jin
authors.initials: HJ
authors.lastname: Chae
authors.affiliation: Department of Laboratory Medicine, Konyang University Hospital, College of Medicine, Konyang University, Daejeon, Korea.
authors.forename: Hyun Jung
authors.initials: HJ
authors.lastname: Cho
authors.affiliation: Department of Laboratory Medicine, Veterans Health Service Medical Center, Seoul, Korea.
authors.forename: Misuk
authors.initials: M
authors.lastname: Ji
authors.affiliation: Department of Laboratory Medicine, School of Medicine, Pusan National University, Busan, Korea.
authors.forename: In Suk
authors.initials: IS
authors.lastname: Kim
authors.affiliation: Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Kyung A
authors.initials: KA
authors.lastname: Wee
authors.affiliation: Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea.
authors.forename: Woochang
authors.initials: W
authors.lastname: Lee
authors.affiliation: Department of Laboratory Medicine, Seoul National University Hospital and College of Medicine, Seoul, Korea.
authors.forename: Sang Hoon
authors.initials: SH
authors.lastname: Song
authors.affiliation: Department of Laboratory Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.
authors.forename: Hye In
authors.initials: HI
authors.lastname: Woo
authors.affiliation: Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. suddenbz@skku.edu.
authors.forename: Soo Youn
authors.initials: SY
authors.lastname: Lee
authors.affiliation: Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea. sailchun@amc.seoul.kr.
authors.forename: Sail
authors.initials: S
authors.lastname: Chun
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use; D000928:Antidepressive Agents / Q000627:therapeutic use; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D000995:Antitubercular Agents / Q000627:therapeutic use; D001191:Arylamine N-Acetyltransferase / Q000235:genetics; D000077144:Clopidogrel; D003324:Coronary Artery Disease / Q000188:drug therapy / Q000235:genetics; D065731:Cytochrome P-450 CYP2C19 / Q000235:genetics; D065729:Cytochrome P-450 CYP2C9 / Q000235:genetics; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics; D003866:Depressive Disorder / Q000188:drug therapy / Q000235:genetics; D005838:Genotype; D007538:Isoniazid / Q000627:therapeutic use; D007755:Laboratories, Hospital / Q000592:standards; D008780:Methyltransferases / Q000235:genetics; D000071185:Pharmacogenomic Testing / Q000379:methods* / Q000592:standards; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D011655:Pulmonary Embolism / Q000188:drug therapy / Q000235:genetics; D013988:Ticlopidine / Q000031:analogs & derivatives / Q000627:therapeutic use; D014376:Tuberculosis / Q000188:drug therapy / Q000235:genetics; D064417:Vitamin K Epoxide Reductases / Q000235:genetics; D014859:Warfarin / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D000928:Antidepressive Agents; D000964:Antimetabolites, Antineoplastic; D000995:Antitubercular Agents; D010975:Platelet Aggregation Inhibitors; D014859:Warfarin; D000077144:Clopidogrel; D065729:Cytochrome P-450 CYP2C9; D065731:Cytochrome P-450 CYP2C19; D019389:Cytochrome P-450 CYP2D6; C578523:VKORC1 protein, human; D064417:Vitamin K Epoxide Reductases; D008780:Methyltransferases; C022745:thiopurine methyltransferase; D001191:Arylamine N-Acetyltransferase; C478900:NAT2 protein, human; D013988:Ticlopidine; D007538:Isoniazid
keywords: Clinical laboratory; Korea; Pharmacogenetics; Practice guideline; Testing