title: Tooth-Matrix Biomarkers to Reconstruct Critical Periods of Brain Plasticity.
abstract: Developmental brain plasticity involves complex, time-dependent dynamic molecular interactions that cannot be observed directly in humans. We propose that the shared evolutionary homology of teeth and the neurosensory system, and the archival nature of dentine microstructure, allows the development of 'biologic hard drives' that can characterize perinatal temporal dynamics in neuroplasticity.
authors.affiliation: Department of Psychiatry, Neuroscience, and Ophthalmology, Friedman Brain Institute, Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: hirofumi.morishita@mssm.edu.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Morishita
authors.affiliation: Division of Environmental Health, Department of Environmental Medicine and Public Health, Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: manish.arora@mssm.edu.
authors.forename: Manish
authors.initials: M
authors.lastname: Arora
mesh_terms: D000818:Animals; D005075:Biological Evolution; D001921:Brain / Q000254:growth & development* / Q000378:metabolism*; D003743:Dental Enamel / Q000254:growth & development / Q000378:metabolism; D003804:Dentin / Q000254:growth & development / Q000378:metabolism; D006801:Humans; D009473:Neuronal Plasticity / Q000502:physiology*; D014070:Tooth / Q000254:growth & development* / Q000378:metabolism*
keywords: biomarker; brain plasticity; critical period; teeth