title: Ibuprofen loaded PVA/chitosan membranes: A highly efficient strategy towards an improved skin wound healing.
abstract: During wound healing, an early inflammation can cause an increase of the wound size and the healing process can be considerably belated if a disproportionate inflammatory response occurs. (S)-ibuprofen (IBP), a non-steroidal anti-inflammatory agent, has been used for muscle healing and to treat venous leg ulcers, but its effect in skin wound healing has not been thoroughly studied thus far. Herein, IBP-β-cyclodextrins carriers were designed to customise the release profile of IBP from poly(vinyl alcohol)/chitosan (PVA/CS) dressings in order to promote a faster skin regeneration. The dressings were produced using supercritical carbon dioxide (scCO2)-assisted technique. In vitro IBP release studies showed that β-cyclodextrins allowed a controlled drug release from the hydrogels which is crucial for their application in wound management. Moreover, the in vivo assays revealed that the presence of PVA/CS membranes containing IBP-β-cyclodextrins carriers avoided scab formation and an excessive inflammation, enabling an earlier skin healing.
authors.affiliation: LAQV-REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, Campus de Caparica, 2829-516 Caparica, Portugal; CICS UBI, Centro de Investigação em Ciências da Saúde, Faculdade de Ciências da Saúde, Universidade da Beira Interior, Av. Infante D Henrique, 6200-506 Covilhã, Portugal.
authors.forename: Patrícia I
authors.initials: PI
authors.lastname: Morgado
authors.affiliation: CICS UBI, Centro de Investigação em Ciências da Saúde, Faculdade de Ciências da Saúde, Universidade da Beira Interior, Av. Infante D Henrique, 6200-506 Covilhã, Portugal.
authors.forename: Sónia P
authors.initials: SP
authors.lastname: Miguel
authors.affiliation: CICS UBI, Centro de Investigação em Ciências da Saúde, Faculdade de Ciências da Saúde, Universidade da Beira Interior, Av. Infante D Henrique, 6200-506 Covilhã, Portugal. Electronic address: icorreia@fcsaude.ubi.pt.
authors.forename: Ilídio J
authors.initials: IJ
authors.lastname: Correia
authors.affiliation: LAQV-REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, Campus de Caparica, 2829-516 Caparica, Portugal. Electronic address: air@fct.unl.pt.
authors.forename: Ana
authors.initials: A
authors.lastname: Aguiar-Ricardo
mesh_terms: D000818:Animals; D001458:Bandages / Q000592:standards; D002478:Cells, Cultured; D048271:Chitosan / Q000737:chemistry*; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000737:chemistry*; D011142:Polyvinyl Alcohol / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000293:injuries*; D014945:Wound Healing
chemical_list: D011142:Polyvinyl Alcohol; D048271:Chitosan; D007052:Ibuprofen
keywords: Composite membranes; Drug delivery systems; Ibuprofen; In vivo assays; Supercritical carbon dioxide; Wound dressings