title: Isolation and identification of a novel sildenafil analogue adulterant in herbal products.
abstract: A novel sildenafil analogue found in herbal products by a routine drug-adulteration screening programme was isolated by column chromatography. On the basis of extensive 1D- and 2D-nuclear magnetic resonance (NMR) spectroscopy and mass spectral analysis, the structure of a new compound YJ-07 was established as 1-[4-ethoxy-3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl) benzenesulfonamide. It common name is aminosildenafil.
authors.affiliation: a Division of Research and Analysis , Taiwan Food and Drug Administration , Taipei City , Taiwan (ROC).
authors.forename: Ya-Tze
authors.initials: YT
authors.lastname: Lin
authors.affiliation: a Division of Research and Analysis , Taiwan Food and Drug Administration , Taipei City , Taiwan (ROC).
authors.forename: Yen-Chun
authors.initials: YC
authors.lastname: Huang
authors.affiliation: a Division of Research and Analysis , Taiwan Food and Drug Administration , Taipei City , Taiwan (ROC).
authors.forename: Hui-Chun
authors.initials: HC
authors.lastname: Lee
authors.affiliation: a Division of Research and Analysis , Taiwan Food and Drug Administration , Taipei City , Taiwan (ROC).
authors.forename: Chen-Hsiang
authors.initials: CH
authors.lastname: Liao
authors.affiliation: b Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources , China Medical University , Taichung , Taiwan (ROC).
authors.forename: Yun-Lian
authors.initials: YL
authors.lastname: Lin
authors.affiliation: a Division of Research and Analysis , Taiwan Food and Drug Administration , Taipei City , Taiwan (ROC).
authors.forename: Chia-Fen
authors.initials: CF
authors.lastname: Tsai
authors.affiliation: a Division of Research and Analysis , Taiwan Food and Drug Administration , Taipei City , Taiwan (ROC).
authors.forename: Hwei-Fang
authors.initials: HF
authors.lastname: Cheng
mesh_terms: D004340:Drug Contamination; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D015394:Molecular Structure; D000068677:Sildenafil Citrate / Q000031:analogs & derivatives* / Q000032:analysis*
chemical_list: D004365:Drugs, Chinese Herbal; D000068677:Sildenafil Citrate
keywords: Sildenafil analogue; aminosildenafil; herbal products; nuclear magnetic resonance (NMR) apparatus