title: Mechanisms of pluripotency maintenance in mouse embryonic stem cells.
abstract: Mouse embryonic stem cells (mESCs), characterized by their pluripotency and capacity for self-renewal, are driven by a complex gene expression program composed of several regulatory mechanisms. These mechanisms collaborate to maintain the delicate balance of pluripotency gene expression and their disruption leads to loss of pluripotency. In this review, we provide an extensive overview of the key pillars of mESC pluripotency by elaborating on the various essential transcription factor networks and signaling pathways that directly or indirectly support this state. Furthermore, we consider the latest developments in the role of epigenetic regulation, such as noncoding RNA signaling or histone modifications.
authors.affiliation: Institute of Biomedical Sciences, Academia Sinica, IBMS Rm.417, 128 Academia Road, Section 2, Nankang, Taipei, 115, Taiwan.
authors.forename: Chen-Yun
authors.initials: CY
authors.lastname: Chen
authors.affiliation: Institute of Biomedical Sciences, Academia Sinica, IBMS Rm.417, 128 Academia Road, Section 2, Nankang, Taipei, 115, Taiwan.|Institute of Life Sciences, National Defense Medical Center, Taipei, 114, Taiwan.
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Cheng
authors.affiliation: Institute of Biomedical Sciences, Academia Sinica, IBMS Rm.417, 128 Academia Road, Section 2, Nankang, Taipei, 115, Taiwan.
authors.forename: Christopher Y T
authors.initials: CY
authors.lastname: Yen
authors.affiliation: Institute of Biomedical Sciences, Academia Sinica, IBMS Rm.417, 128 Academia Road, Section 2, Nankang, Taipei, 115, Taiwan. phsieh@ibms.sinica.edu.tw.|Institute of Life Sciences, National Defense Medical Center, Taipei, 114, Taiwan. phsieh@ibms.sinica.edu.tw.|Institute of Medical Genomics and Proteomics, Institute of Clinical Medicine and Department of Surgery, National Taiwan University and Hospital, Taipei, 100, Taiwan. phsieh@ibms.sinica.edu.tw.|Institute of Clinical Medicine, National Cheng Kung University, Tainan, 701, Taiwan. phsieh@ibms.sinica.edu.tw.
authors.forename: Patrick C H
authors.initials: PC
authors.lastname: Hsieh
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D049109:Cell Proliferation; D042002:Chromatin Assembly and Disassembly; D044127:Epigenesis, Genetic; D018507:Gene Expression Regulation, Developmental; D053263:Gene Regulatory Networks; D042421:Histone Code; D051379:Mice; D000066450:Mouse Embryonic Stem Cells / Q000166:cytology / Q000378:metabolism*; D022661:RNA, Untranslated / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D015533:Transcriptional Activation
chemical_list: D022661:RNA, Untranslated; D014157:Transcription Factors
keywords: Epigenetic regulation; Mouse embryonic stem cells; Pluripotency; Transcriptional regulation