title: HBV Infection Status and the Risk of Cholangiocarcinoma in Asia: A Meta-Analysis.
abstract: Background. The inconsistent finding was between hepatitis B virus (HBV) infections and cholangiocarcinoma (CCA). This meta-analysis is to explore this relationship in Asia.Methods. A literature search was performed using PubMed, Web of Science, and Cochrane Library to October 30, 2015. Pooled incidence rate and OR with 95% CI were calculated using STATA 11.0.Results. Thirty-nine studies were included. The pooled incidence rate of CCA patients with HBV infection was 31% (95% CI 22%-39%). The pooled OR showed increased risk of CCA incidence with HBV infection (OR = 2.72, 95% CI 1.90-3.88), especially in ICC (OR = 3.184, 95% CI 2.356-4.302), while it showed no risk in ECC (OR = 1.407, 95% CI 0.925-2.141). Also, the pooled OR showed increased risk of ICC and ECC incidence (OR = 6.857, 95% CI 4.421-10.633 and OR = 1.740, 95% CI 1.260-2.404) in patients with HBsAg+/HBcAb+. The pooled OR showed increased risk of ICC incidence (OR = 1.410, 95% CI 1.095-1.816) in patients with HBsAg-/HBcAb+.Conclusion. It is suggested that HBV infection is associated with an increased risk of CCA in Asia. Two HBV infection models (HBsAg+/HBcAb+ and HBsAg-/HBcAb+) increase the risk of CCA, and patients with HBsAg-/HBcAb+ also had a risk of ICC. This trial is registered with PROSPERO CRD42015029264.
authors.affiliation: Department of Infectious Diseases, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Yanjiang Road 151, Guangzhou 510120, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Laboratory Medicine, Dongguan Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Songshan Lake Avenue 22, Dongcheng District, Dongguan 523000, China.
authors.forename: Biqing
authors.initials: B
authors.lastname: Zhu
authors.affiliation: Department of Infectious Diseases, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Yanjiang Road 151, Guangzhou 510120, China.
authors.forename: He
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Infectious Diseases, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Yanjiang Road 151, Guangzhou 510120, China.
authors.forename: Jianxin
authors.initials: J
authors.lastname: Liang
authors.affiliation: Department of Infectious Diseases, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Yanjiang Road 151, Guangzhou 510120, China.
authors.forename: Wenting
authors.identifier: 0000-0003-2372-5066
authors.initials: W
authors.lastname: Zeng
mesh_terms: D001650:Bile Duct Neoplasms / Q000453:epidemiology / Q000821:virology; D018281:Cholangiocarcinoma / Q000453:epidemiology / Q000821:virology; D005260:Female; D006509:Hepatitis B / Q000453:epidemiology*; D006515:Hepatitis B virus; D006801:Humans; D015994:Incidence; D008297:Male; D008954:Models, Biological; D012307:Risk Factors