title: Radiogenomic evaluation of lung cancer - Are there imaging characteristics associated with lung adenocarcinomas harboring BRAF mutations?
abstract: BACKGROUND
  We studied computed tomography (CT) features associated with BRAF mutated lung cancer.
  
  
  METHODS
  CT features of BRAF mutated lung cancers were compared to stage matched lesions without BRAF mutation.
  
  
  RESULTS
  47 (25%) patients with BRAF mutation and 141 (75%) without BRAF mutation were included. BRAF lesions were most frequently solid 37 (84%), spiculated 22 (50%), and peripheral 37 (84%). No feature of the primary tumor was significantly different between BRAF and non-BRAF groups. BRAF patients were more likely than KRAS patients to have pleural metastases [5 (11%) vs 0 (0%), p=0.045].
  
  
  CONCLUSIONS
  No feature of the primary tumor differentiates BRAF lesions from non-BRAF lesions.
authors.affiliation: Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. Electronic address: halpennd@mskcc.org.
authors.forename: Darragh F
authors.initials: DF
authors.lastname: Halpenny
authors.affiliation: Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Plodkowski
authors.affiliation: Department of Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
authors.forename: Gregory
authors.initials: G
authors.lastname: Riely
authors.affiliation: Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
authors.forename: Junting
authors.initials: J
authors.lastname: Zheng
authors.affiliation: Department of Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
authors.forename: Anya
authors.initials: A
authors.lastname: Litvak
authors.affiliation: Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
authors.forename: Chaya
authors.initials: C
authors.lastname: Moscowitz
authors.affiliation: Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
authors.forename: Michelle S
authors.initials: MS
authors.lastname: Ginsberg
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging* / Q000235:genetics / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000235:genetics / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009154:Mutation; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics*; D014057:Tomography, X-Ray Computed
chemical_list: D048493:Proto-Oncogene Proteins B-raf
keywords: BRAF mutation; Computed tomography; Lung carcinoma; Radiogenomics