title: Optical coherence tomography: A quantitative tool to measure neurodegeneration and facilitate testing of novel treatments for tissue protection in multiple sclerosis.
abstract: Optical coherence tomography (OCT) is a relatively new imaging technology that has been introduced as a powerful biomarker in neurological disease, including multiple sclerosis. In this review, OCT as an imaging technique, its reproducibility and validation in multiple sclerosis, application to other neurodegenerative diseases and future technological directions are discussed.
authors.affiliation: Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore, MD, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Eliza
authors.initials: E
authors.lastname: Gordon-Lipkin
authors.affiliation: Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: pcalabr1@jhmi.edu.
authors.forename: Peter A
authors.initials: PA
authors.lastname: Calabresi
mesh_terms: D000818:Animals; D006801:Humans; D009103:Multiple Sclerosis / Q000000981:diagnostic imaging* / Q000628:therapy; D009410:Nerve Degeneration / Q000000981:diagnostic imaging* / Q000628:therapy; D009900:Optic Nerve / Q000000981:diagnostic imaging; D012160:Retina / Q000000981:diagnostic imaging*; D041623:Tomography, Optical Coherence / Q000379:methods* / Q000639:trends; D016896:Treatment Outcome
keywords: Multiple sclerosis; Neurodegeneration; Neuroimaging; Optical coherence tomography