title: Opportunities in low-level radiocarbon microtracing: applications and new technology.
abstract: 14C-radiolabeled (radiocarbon) drug studies are central to defining the disposition of therapeutics in clinical development. Concerns over radiation, however, have dissuaded investigators from conducting these studies as often as their utility may merit. Accelerator mass spectrometry (AMS), originally designed for carbon dating and geochronology, has changed the outlook for in-human radiolabeled testing. The high sensitivity of AMS affords human clinical testing with vastly reduced radiative (microtracing) and chemical exposures (microdosing). Early iterations of AMS were unsuitable for routine biomedical use due to the instruments' large size and associated per sample costs. The situation is changing with advances in the core and peripheral instrumentation. We review the important milestones in applied AMS research and recent advances in the core technology platform. We also look ahead to an entirely new class of14C detection systems that use lasers to measure carbon dioxide in small gas cells.
authors.affiliation: Sivvon Biolabs, 1520 E, Covell 311, Davis, CA 95618, USA; Sivvon Biolabs, 1520 E, Covell 311, Davis, CA 95618, USA.
authors.forename: Le Thuy
authors.initials: LT
authors.lastname: Vuong
authors.affiliation: Sivvon Biolabs, 1520 E, Covell 311, Davis, CA 95618, USA; Sivvon Biolabs, 1520 E, Covell 311, Davis, CA 95618, USA.
authors.forename: Qi
authors.initials: Q
authors.lastname: Song
authors.affiliation: BioCore Co., Ltd, Seoul, IT Mi-Rae Tower, 8F (33 Digitalro 9-ghil) #60-21 Gasan-dong, Geumcheon-gu, Seoul, South Korea 08511; BioCore Co., Ltd, Seoul, IT Mi-Rae Tower, 8F (33 Digitalro 9-ghil) #60-21 Gasan-dong, Geumcheon-gu, Seoul, South Korea 08511.
authors.forename: Hee Joo
authors.initials: HJ
authors.lastname: Lee
authors.affiliation: PRA Health Sciences, Stationsweg 163 9471 GP Zuidlaren, The Netherlands; PRA Health Sciences, Stationsweg 163 9471 GP Zuidlaren, The Netherlands.
authors.forename: Ad F
authors.initials: AF
authors.lastname: Roffel
authors.affiliation: College of Pharmacy, Chungnam National University College of Pharmacy, 99 Daehak-ro, Yuseong-gu, Daejeon, South Korea 305-764; College of Pharmacy, Chungnam National University College of Pharmacy, 99 Daehak-ro, Yuseong-gu, Daejeon, South Korea 305-764.
authors.forename: Seok-Ho
authors.initials: SH
authors.lastname: Shin
authors.affiliation: College of Pharmacy, Chungnam National University College of Pharmacy, 99 Daehak-ro, Yuseong-gu, Daejeon, South Korea 305-764; College of Pharmacy, Chungnam National University College of Pharmacy, 99 Daehak-ro, Yuseong-gu, Daejeon, South Korea 305-764.
authors.forename: Young G
authors.initials: YG
authors.lastname: Shin
authors.affiliation: Sivvon Biolabs, 1520 E, Covell 311, Davis, CA 95618, USA; BioCore Co., Ltd, Seoul, IT Mi-Rae Tower, 8F (33 Digitalro 9-ghil) #60-21 Gasan-dong, Geumcheon-gu, Seoul, South Korea 08511; College of Pharmacy, Chungnam National University College of Pharmacy, 99 Daehak-ro, Yuseong-gu, Daejeon, South Korea 305-764; Sivvon Biolabs, 1520 E, Covell 311, Davis, CA 95618, USA; BioCore Co., Ltd, Seoul, IT Mi-Rae Tower, 8F (33 Digitalro 9-ghil) #60-21 Gasan-dong, Geumcheon-gu, Seoul, South Korea 08511; College of Pharmacy, Chungnam National University College of Pharmacy, 99 Daehak-ro, Yuseong-gu, Daejeon, South Korea 305-764.
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Dueker
keywords: AMS; accelerator mass spectrometry; cavity ring-down spectroscopy; microdosing; microtracing; pediatrics; radiocarbon