title: Triterpene saponins from the roots of Acacia albida Del. (Mimosaceae).
abstract: Seven previously undescribed bidesmosidic triterpenoid saponins named albidosides A - G, were isolated from a methanol extract of the roots of Acacia albida. Their structures were elucidated using 1D and 2D NMR spectroscopy and mass spectrometry and determined to be bidesmosides of oleanolic acid and of 16α-hydroxyoleanolic acid. Albidosides B - G were assayed for their cytotoxicity against HeLa and HL60 cells using MTT method and microscopic observation.
authors.affiliation: Department of Organic Chemistry, University of Yaounde 1, P.O. Box 812, Yaounde, Cameroon; Faculty of Agriculture, Yamagata University, 1-23, Wakaba-machi, Tsuruoka, Yamagata, 997-8555, Japan.
authors.forename: Abdou
authors.initials: A
authors.lastname: Tchoukoua
authors.affiliation: Department of Organic Chemistry, University of Yaounde 1, P.O. Box 812, Yaounde, Cameroon. Electronic address: ttabopda@yahoo.fr.
authors.forename: Turibio Kuiate
authors.initials: TK
authors.lastname: Tabopda
authors.affiliation: Laboratory of Chemical Biology, The United Graduate School of Agricultural Sciences, Iwate University, Morioka, Iwate 020-8550, Japan.
authors.forename: Shota
authors.initials: S
authors.lastname: Uesugi
authors.affiliation: Laboratory of Chemical Biology, The United Graduate School of Agricultural Sciences, Iwate University, Morioka, Iwate 020-8550, Japan.
authors.forename: Misa
authors.initials: M
authors.lastname: Ohno
authors.affiliation: Laboratory of Chemical Biology, The United Graduate School of Agricultural Sciences, Iwate University, Morioka, Iwate 020-8550, Japan; Graduate School of Agriculture, Iwate University, Morioka, Iwate 020-8550, Japan.
authors.forename: Ken-Ichi
authors.initials: KI
authors.lastname: Kimura
authors.affiliation: Research and Analytical Center for Giant Molecules, Graduate School of Science, Tohoku University, Sendai, Miyagi 980-8578, Japan.
authors.forename: Eunsang
authors.initials: E
authors.lastname: Kwon
authors.affiliation: Research and Analytical Center for Giant Molecules, Graduate School of Science, Tohoku University, Sendai, Miyagi 980-8578, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Momma
authors.affiliation: Department of Chemistry, Faculty of Science, Ege University, 35100, Bornova, İzmir, Turkey.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Horo
authors.affiliation: Department of Chemistry, Faculty of Science, Ege University, 35100, Bornova, İzmir, Turkey.
authors.forename: Özgen Alankuş
authors.initials: ÖA
authors.lastname: Çalişkan
authors.affiliation: Faculty of Agriculture, Yamagata University, 1-23, Wakaba-machi, Tsuruoka, Yamagata, 997-8555, Japan. Electronic address: yshiono@tds1.tr.yamagata-u.ac.jp.
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Shiono
authors.affiliation: Department of Organic Chemistry, University of Yaounde 1, P.O. Box 812, Yaounde, Cameroon; Department of Medicine and Traditional Pharmacopoeia, Faculty of Medicine and Biomedical Sciences, University of Yaounde 1, P.O. Box 1364, Yaoundé, Cameroon. Electronic address: ngadjuibt@yahoo.fr.
authors.forename: Bonaventure Tchaleu
authors.initials: BT
authors.lastname: Ngadjui
mesh_terms: D000045:Acacia / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002163:Cameroon; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins; C000614634:albidoside A; D009828:Oleanolic Acid
keywords: Acacia albida; Cytotoxicity; Mimosaceae; Triterpene saponins