title: Successful Pregnancy Outcome in Women with Recurrent IVF Failure and Anti-hCG Autoimmunity: A Report of Three Cases.
abstract: We report three cases of effective management of infertility in women with a history of repeated unsuccessful IVF attempts, who have developed antibodies to hCG. A novel approach to conservative treatment of immunologic reproductive failure, suggested for selected patients, included membrane plasmapheresis, combined prednisolone, and intravenous immunoglobulin therapy. No adverse side effects were observed; all cases resulted in pregnancy and subsequent life births. In order to be given an adequate efficient treatment, women with recurrent implantation failure should be suspected for autoimmune factor of infertility and its possible association with anti-hCG autoimmunity.
authors.affiliation: Department of Assisted Reproduction Technologies, FSBI D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Saint Petersburg, Russia.
authors.forename: Valeria
authors.identifier: 0000-0002-0849-2607
authors.initials: V
authors.lastname: Muller
authors.affiliation: Department of Assisted Reproduction Technologies, FSBI D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Saint Petersburg, Russia.
authors.forename: Ksenia
authors.initials: K
authors.lastname: Ob'edkova
authors.affiliation: Department of Assisted Reproduction Technologies, FSBI D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Saint Petersburg, Russia.
authors.forename: Inna
authors.initials: I
authors.lastname: Krikheli
authors.affiliation: Department of Assisted Reproduction Technologies, FSBI D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Saint Petersburg, Russia.
authors.forename: Igor
authors.initials: I
authors.lastname: Kogan
authors.affiliation: Department of Assisted Reproduction Technologies, FSBI D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Saint Petersburg, Russia.
authors.forename: Irina
authors.initials: I
authors.lastname: Fedorova
authors.affiliation: Department of Assisted Reproduction Technologies, FSBI D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Saint Petersburg, Russia.
authors.forename: Elena
authors.initials: E
authors.lastname: Lesik
authors.affiliation: Department of Assisted Reproduction Technologies, FSBI D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Saint Petersburg, Russia.
authors.forename: Evgenia
authors.initials: E
authors.lastname: Komarova
authors.affiliation: Department of Assisted Reproduction Technologies, FSBI D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Saint Petersburg, Russia.
authors.forename: Alexandr
authors.initials: A
authors.lastname: Gzgzyan