title: Adult neurogenesis beyond the niche: its potential for driving brain plasticity.
abstract: Adult neurogenesis emerges as a tremendous form of plasticity with the continuous addition and loss of neurons in the adult brain. It is unclear how preexisting adult circuits generated during development are capable of modifying existing connections to accommodate the thousands of new synapses formed and exchanged each day. Here we first make parallels with sensory deprivation studies and its ability to induce preexisting non-neurogenic adult circuits to undergo massive reorganization. We then review recent studies that show high structural and synaptic plasticity in circuits directly connected to adult-born neurons. Finally, we propose future directions in the field to decipher how host circuits can accommodate new neuron integration and to determine the impact of adult neurogenesis on global brain plasticity.
authors.affiliation: Laboratory for Perception and Memory, Pasteur Institute, F-75015 Paris, France; Centre National de la Recherche Scientifique (CNRS), Unité de Recherche Associée (UMR3571), F-75015 Paris, France.
authors.forename: Kurt A
authors.initials: KA
authors.lastname: Sailor
authors.affiliation: Laboratory of Neuronal Plasticity, Leloir Institute (IIBBA - CONICET), Av. Patricias Argentinas 435, Buenos Aires C1405BWE, Argentina.
authors.forename: Alejandro F
authors.initials: AF
authors.lastname: Schinder
authors.affiliation: Laboratory for Perception and Memory, Pasteur Institute, F-75015 Paris, France; Centre National de la Recherche Scientifique (CNRS), Unité de Recherche Associée (UMR3571), F-75015 Paris, France. Electronic address: pmlledo@pasteur.fr.
authors.forename: Pierre-Marie
authors.initials: PM
authors.lastname: Lledo
mesh_terms: D001921:Brain / Q000502:physiology*; D055495:Neurogenesis / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D013569:Synapses / Q000502:physiology