title: [Increased eosinophils in nasal exudation after allergic rhinitis nasal provocation are positively correlated with serum level of specific IgE].
abstract: Objective To study the relationship between specific nasal provocation test (SNPT) and serum specific IgE level in the patients with allergic rhinitis, and analyze the correlation between the eosinophil (EOS) percentage in nasal secretion and serum specific IgE level. Methods SNPT was performed in 80 cases of perennial allergic rhinitis due to dust mites. Specific IgE in the serum of those patients was detected by Unicap. EOS percentage in nasal secretions was recorded before and after SNPT. The correlation of EOS percentage and serum level of specific IgE was analyzed by Kendall's tau-b test. Results The positive result of SNPT had a concordance with serum specific IgE in recruited patients. And the increased EOS percentage in nasal secretions after SNPT had a positive correlation with the level of serum specific IgE. Conclusion Positive SNPT can be used as a diagnostic index of allergic rhinitis. And the increased percentage of EOS in nasal secretions after SNPT can also help evaluate the severity of allergic rhinitis.
authors.affiliation: Department of Allergy, Second Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260, China.
authors.forename: Yongping
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Allergy, Second Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260, China.
authors.forename: Yunguang
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Guangdong Provincial Key Laboratory of Allergy & Clinical Immunology, Guangzhou 510260, China.
authors.forename: Junbin
authors.initials: J
authors.lastname: Zheng
authors.affiliation: Department of Allergy, Second Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260; Guangdong Provincial Key Laboratory of Allergy & Clinical Immunology, Guangzhou 510260, China. *Corresponding author, E-mail: april0860@163.com.
authors.forename: Shan
authors.initials: S
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D004804:Eosinophils / Q000276:immunology*; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000276:immunology*; D009299:Nasal Provocation Tests / Q000379:methods; D065631:Rhinitis, Allergic / Q000097:blood / Q000276:immunology*; D055815:Young Adult
chemical_list: D007073:Immunoglobulin E