title: Sister Mary Joseph's nodule as initial pancreatic cancer manifestation.
abstract: We report the case of an 85-year-old female patient who presented with umbilical pain associated with an indurated growth, the whole being apparently consistent with incarcerated umbilical hernia, which prompted an urgent surgical procedure for its removal. The pathology study revealed dermal infiltration by a malignancy. Gland tumor cells expressed an immunohistochemical profile initially consistent with a pancreatic origin. In view of these findings a CT scan was performed, which revealed a pancreatic tail tumor as well as multiple hepatic metastasis. Skin metastasis is a rare sign usually reflecting a carcinoma of unknown origin. Umbilical skin metastasis, called Sister Mary Joseph´s nodule, reflect an intra-abdominal tumor, being pancreatic cancer strange.
authors.affiliation: Cirugía General y del Aparato Digestivo, Hospital Universitario Miguel Servet, España.
authors.forename: Cristina
authors.initials: C
authors.lastname: Vallejo Bernad
authors.affiliation: Cirugía General y del Aparato Digestivo, Hospital Universitario Miguel Servet.
authors.forename: María Carmen
authors.initials: MC
authors.lastname: Casamayor Franco
authors.affiliation: Anatomía Patológica, Hospital Universitario Miguel Servet.
authors.forename: Sofía
authors.initials: S
authors.lastname: Hakim Alonso
mesh_terms: D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D058288:Sister Mary Joseph's Nodule / Q000000981:diagnostic imaging / Q000473:pathology*; D014057:Tomography, X-Ray Computed