title: Relevant Discordance Between 68Ga-DOTATATE and 68Ga-DOTANOC in SDHB-Related Metastatic Paraganglioma: Is Affinity to Somatostatin Receptor 2 the Key?
abstract: Pheochromocytomas/paragangliomas are somatostatin receptor 2-overexpressing tumors. Ga-DOTA-peptide imaging has recently shown excellent results in the detection of metastatic lesions in these tumors. However, currently used Ga-DOTA peptides show different somatostatin receptor affinities. Here, we report the remarkable differences in a patient who was imaged with Ga-DOTANOC and Ga-DOTATATE PET/CT within a 7-month period. The patient presented with a nearly negative Ga-DOTANOC PET/CT scan, whereas on Ga-DOTATATE PET/CT, multiple highly positive lesions were identified.
authors.affiliation: From the *Section on Medical Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD; †Surgery Centre for Children, Mount Elizabeth Medical Centre, Singapore; and ‡Positron Emission Tomography Department, National Institutes of Health Clinical Center, National Institutes of Health, Bethesda, MD.
authors.forename: Ingo
authors.initials: I
authors.lastname: Janssen
authors.forename: Katherine I
authors.initials: KI
authors.lastname: Wolf
authors.forename: Chan H
authors.initials: CH
authors.lastname: Chui
authors.forename: Corina M
authors.initials: CM
authors.lastname: Millo
authors.forename: Karel
authors.initials: K
authors.lastname: Pacak
mesh_terms: D000008:Abdominal Neoplasms / Q000000981:diagnostic imaging* / Q000235:genetics / Q000473:pathology; D002648:Child; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary*; D009362:Neoplasm Metastasis; D009942:Organometallic Compounds; D010235:Paraganglioma / Q000000981:diagnostic imaging* / Q000235:genetics / Q000473:pathology; D000072078:Positron Emission Tomography Computed Tomography; D011485:Protein Binding; D019275:Radiopharmaceuticals; D017481:Receptors, Somatostatin / Q000378:metabolism*; D013385:Succinate Dehydrogenase / Q000235:genetics
chemical_list: C504894:68Ga-DOTANOC; D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; D017481:Receptors, Somatostatin; C513399:gallium Ga 68 dotatate; C093733:somatostatin receptor 2; C108095:SDHB protein, human; D013385:Succinate Dehydrogenase