title: [Toxic alcohol poisonings].
abstract: Accidental or intentional poisonings with ethylene glycol or methanol constitute a serious toxicological problem in many countries. Both alcohols are quickly metabolized by alcohol dehydrogenase to toxic metabolites responsible for high anion gap severe metabolic acidosis and profound neurological, cardiopulmonary, renal disturbances and death. In the early period, the competing inhibition the alcohol dehydrogenase with ethanol or fomepizol may successfully prevent the formation of the toxic metabolites. Once severe acidosis develops an emergency hemodialysis is required.
authors.affiliation: Katedra i Klinika Nefrologii, Dializoterapii i Chorób Wewnętrznych WUM, Warszawa, Polska, pkulicki@wp.pl.
authors.forename: Paweł
authors.initials: P
authors.lastname: Kulicki
authors.affiliation: Katedra i Klinika Nefrologii, Dializoterapii i Chorób Wewnętrznych WUM, Warszawa, Polska.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Głogowski
mesh_terms: D000437:Alcoholism / Q000150:complications*; D000431:Ethanol / Q000506:poisoning*; D019855:Ethylene Glycol / Q000506:poisoning*; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced* / Q000628:therapy*; D000432:Methanol / Q000506:poisoning*
chemical_list: D000431:Ethanol; D019855:Ethylene Glycol; D000432:Methanol
keywords:  ethanol;  ethylene glycol;  hemodialysis ;  metabolic acidosis;  methanol;  serum anion gap; toxic alcohols