title: The effects of IL-1A and IL-6 genes polymorphisms on gene expressions, hormonal and biochemical parameters in polycystic ovary syndrome.
abstract: Polycystic ovary syndrome (PCOS) is a multifactorial disease characterised by chronic inflammation. We aimed to investigate an association between IL-1A and IL-6 gene polymorphisms and both hormonal/biochemical parameters and levels of IL-1A and IL-6. A total of 103 women diagnosed with PCOS according to ESHRE/ASRM criteria were investigated. The patients were divided into two groups as obese and non-obese. IL-1A and IL-6 genes polymorphisms as well as hormonal/biochemical parameters and levels of IL-1A and IL-6 were analysed in the same groups. Serum IL-1A and IL-6 levels were found to increase both in obese and non-obese groups. However, there was no association between IL-1A level and IL-1A polymorphism. A relationship was detected between H score, FSH, LH, total testosterone, HDL-C and TG levels and CG + GG genotypes of IL-6. Furthermore, an association was found between IL-6 levels and CC genotype of IL-6 in the obese PCOS patients. The abnormalities in hormonal/biochemical parameters detected in Turkish PCOS patients may be related with IL-6 gene polymorphism rather than IL-1A.
authors.affiliation: a Department of Medical Genetics, Faculty of Medicine , Balikesir University , Balikesir , Turkey.
authors.forename: Betul
authors.initials: B
authors.lastname: Eser
authors.affiliation: b Department of Gynecology and Obstetrics, Faculty of Medicine , Balikesir University , Balikesir , Turkey.
authors.forename: Mine
authors.initials: M
authors.lastname: Islimye Taskin
authors.affiliation: c Department of Biochemistry, Faculty of Medicine , Balikesir University , Balikesir , Turkey.
authors.forename: Adnan Adil
authors.initials: AA
authors.lastname: Hismiogullari
authors.affiliation: d Department of Biochemistry, Faculty of Veterinary Medicine , Balikesir University , Balikesir , Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Aksit
authors.affiliation: e Department of Public Health, Faculty of Medicine , Balikesir University , Balikesir , Turkey.
authors.forename: Abdurrahman Said
authors.initials: AS
authors.lastname: Bodur
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D015870:Gene Expression; D005787:Gene Frequency; D006801:Humans; D007333:Insulin Resistance; D053582:Interleukin-1alpha / Q000097:blood / Q000235:genetics*; D015850:Interleukin-6 / Q000097:blood / Q000235:genetics*; D007986:Luteinizing Hormone / Q000097:blood; D009765:Obesity / Q000150:complications / Q000503:physiopathology*; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D013739:Testosterone / Q000097:blood; D055815:Young Adult
chemical_list: D015415:Biomarkers; D053582:Interleukin-1alpha; D015850:Interleukin-6; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
keywords: Expression; gene polymorphisms; interleukins; polycystic ovary syndrome