title: Clinical and Preclinical Cognitive Function Improvement after Oral Treatment of a Botanical Composition Composed of Extracts fromScutellaria baicalensisandAcacia catechu.
abstract: Dementia and cognitive impairment have become the major concerns worldwide due to a significantly aging population, increasing life span and lack of effective pharmacotherapy. In light of limited pharmaceutical drug choices and the socioeconomic implications of these conditions, the search for safe and effective alternatives from natural sources has gained many attractions within the medical food and dietary supplement industry. Two polyphenol extracts derived from roots ofScutellaria baicalensisand heartwoods ofAcacia catechucontaining free-B-ring flavonoids and flavans, respectively, were combined into a proprietary blend called UP326. A similar bioflavonoid composition, UP446, has been reported with modulation of pathways related to systemic inflammation. To test the effect of UP326 on memory and learning, a radial arm water maze (RAWM) and contextual fear conditioning (CF) were utilized in aged F344 rats fed with UP326 at doses of 3, 7, and 34 mg/kg for 11 weeks. The 7 and 34 mg/kg dosage groups had significantly fewer errors than aged vehicle control animals and their performance was equivalent to young animal controls. In a separate human clinical trial, test subjects orally given 300 mg of UP326 BID for 30 days showed marked improvement in speed and accuracy of processing complex information in computer tasks and reduced their standard deviation of performance compared to baseline and the placebo group. This data suggest that UP326 may help maintain memory, sustain speed of processing, and reduce the number or memory errors as we age.
authors.affiliation: Unigen, Inc., 3005 1st Ave., Seattle, WA 98121, USA.
authors.forename: Mesfin
authors.identifier: 0000-0001-5009-1586
authors.initials: M
authors.lastname: Yimam
authors.affiliation: Entera Health, Inc., 2000 Regency Parkway, Ste. 200, Cary, NC 27518, USA.
authors.forename: Bruce P
authors.identifier: 0000-0001-5800-6622
authors.initials: BP
authors.lastname: Burnett
authors.affiliation: Unigen, Inc., 3005 1st Ave., Seattle, WA 98121, USA.
authors.forename: Lidia
authors.initials: L
authors.lastname: Brownell
authors.affiliation: Unigen, Inc., 3005 1st Ave., Seattle, WA 98121, USA.
authors.forename: Qi
authors.initials: Q
authors.lastname: Jia
mesh_terms: D000045:Acacia; D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000818:Animals; D003071:Cognition / Q000187:drug effects*; D004195:Disease Models, Animal; D005419:Flavonoids / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy*; D007858:Learning / Q000187:drug effects*; D008568:Memory / Q000187:drug effects*; D008875:Middle Aged; D010936:Plant Extracts / Q000008:administration & dosage / Q000627:therapeutic use*; D011916:Rats, Inbred F344; D031364:Scutellaria baicalensis
chemical_list: D005419:Flavonoids; D010936:Plant Extracts; C499814:Scutellaria baicalensis extract