title: Tetracyclines metal complexation: Significance and fate of mutual existence in the environment.
abstract: Concern over tetracyclines (TCs) complexation with metals in the environment is growing as a new class of emerging contaminants. TCs exist as a different net charged species depending on their dissociation constants, pH and the surrounding environment. One of the key concerns about TCs is its strong tendency to interact with various metal ions and form metal complexes. Moreover, co-existence of TCs and metals in the environment and their interactions has shown increased antibiotic resistance. Despite extensive research on TCs complexation, investigations on their antibiotic efficiency and pharmacological profile in bacteria have been limited. In addition, the current knowledge on TCs metal complexation, their fate and risk assessment in the environment are inadequate to obtain a clear understanding of their consequences on living systems. This indicates that vital and comprehensive studies on TCs-metal complexation, especially towards growing antibiotic resistance trends are required. This review summarizes the role of TCs metal complexation on the development of antibiotic resistance. Furthermore, impact of metal complexation on degradation, toxicity and the fate of TCs in the environment are discussed and future recommendations have been made.
authors.affiliation: INRS-ETE, Université du Québec, 490, Rue de la Couronne, Québec G1K 9A9, Canada.
authors.forename: Rama
authors.initials: R
authors.lastname: Pulicharla
authors.affiliation: INRS-ETE, Université du Québec, 490, Rue de la Couronne, Québec G1K 9A9, Canada.
authors.forename: Krishnamoorthy
authors.initials: K
authors.lastname: Hegde
authors.affiliation: INRS-ETE, Université du Québec, 490, Rue de la Couronne, Québec G1K 9A9, Canada. Electronic address: satinder.brar@ete.inrs.ca.
authors.forename: Satinder Kaur
authors.initials: SK
authors.lastname: Brar
authors.affiliation: Department of Civil Engineering, University of Nebraska-Lincoln, N104 SEC PO Box 886105, Lincoln, NE 68588-6105, USA.
authors.forename: Rao Y
authors.initials: RY
authors.lastname: Surampalli
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry*; D056831:Coordination Complexes / Q000737:chemistry*; D004785:Environmental Pollutants / Q000737:chemistry*; D007477:Ions; D008670:Metals; D013754:Tetracyclines / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D056831:Coordination Complexes; D004785:Environmental Pollutants; D007477:Ions; D008670:Metals; D013754:Tetracyclines
keywords: Complexation; Environment; Metals; Resistance; Tetracyclines; Toxicity