title: Ambient ionization and miniature mass spectrometry system for chemical and biological analysis.
abstract: Ambien ionization and miniaturization of mass spectrometers are two fields in mass spectrometry that have advanced significantly in the last decade. The integration of the techniques developed in these two fields is leading to the development of complete miniature analytical systems that can be used for on-site or point-of-care analysis by non-expert users. In this review, we report the current status of development in ambient ionization and miniature mass spectrometers, with an emphasis on those techniques with potential impact on the point-of-care (POC) diagnostics. The challenges in the future development of the integrated systems are discussed with possible solutions presented.
authors.affiliation: Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47906.
authors.forename: Xiaoxiao
authors.initials: X
authors.lastname: Ma
authors.affiliation: Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47906.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Ouyang
keywords: Ambient ionization; Biomarker; Miniature mass spectrometer; Quantitative analysis; Therapeutic drug monitoring