title: Cu-Catalyzed electrophilic amination of internal alkynes via hydroalumination.
abstract: A straightforward and efficient method for the synthesis of 1,2-diaryl-substituted enamines through the Cu-catalyzed electrophilic amination reaction of O-benzoyl hydroxylamines with vinylaluminum reagents generated in situ from the Ni-catalyzed hydroalumination of readily accessible internal aryl acetylenes is described. The amination is catalyzed by 1 mol% CuCl without any additive at ambient temperature to afford new versatile enamines in good yield (61-91%) with high selectivity (>98% E-enamine).
authors.affiliation: Department of Chemistry, Kwangwoon University, Seoul 01897, Republic of Korea. ymlee@kw.ac.kr.
authors.forename: Hongju
authors.initials: H
authors.lastname: Yoon
authors.affiliation: Department of Chemistry, Kwangwoon University, Seoul 01897, Republic of Korea. ymlee@kw.ac.kr.
authors.forename: Yuna
authors.initials: Y
authors.lastname: Kim
authors.affiliation: Department of Chemistry, Kwangwoon University, Seoul 01897, Republic of Korea. ymlee@kw.ac.kr.
authors.forename: Yunmi
authors.identifier: http://orcid.org/0000-0003-1315-4001
authors.initials: Y
authors.lastname: Lee