title: [EFFICACY OF COMBINED USE OF ANTIOXIDATIVE AND PHOTOTHERAPY IN THE TREATMENT OF VITILIGO].
abstract: Despite of numerous investigations, carried out practically in all countries of the world for the study of vitiligo and the search for its new effective therapies, pathogenic mechanisms of vitiligo are still poorly understood, and the proposed treatments are not perfect. One of the most accepted theories of the pathogenesis of vitiligo is an oxidative stress theory, according to which a series of biochemical anomalies cause oxidative stress, leading to accumulation of melanocytotoxic substances and inhibition of natural processes of detoxification with subsequent destruction of melanocytes in vitiligo focus. On the other hand, the use of antioxidants in combination with ultraviolet therapy of dermatological diseases, has been theoretically proved by biophysical studies, according to which- the antioxidants inhibit the oxidation of products, formed in the skin after ultraviolet irradiation and greatly reduce erythema sensitivity (1.5-2 times). Due to this effect, the power of radiation exposure can be approximately increased many times. Based on the foregoing, the use of antioxidants during phototherapy of vitiligo pathogenetically is justified. The aim of the study was to evaluate the therapeutic efficacy of Se ACE in treatment of patients with various forms of vitiligo. 35 patients (23 women and 12 men) aged 18 to 40 years with duration of the pathological process from 2 months to 15 years were under observation. 17 of these were diagnosed with a form of non segmental vitiligo (NSV), 18- segmental vitiligo. In 11 patients onset of the disease was not connected with any other problem, 24 noted the appearance of white spots after stress. Vitiligo patients were divided into 2 groups: the study group and the group of comparison. The study group included 17 patients (9 women and 8 men) aged 18 to 40 years with duration of the disease from 2 months to 5 years. The comparison group consisted of 18 patients (10 women and 8 men). Distribution of patients in both groups was homologous by the sex, age, duration and clinical forms of dermatosis. All patients underwent phototherapy. In the study group Selenium was used as an antioxidant, which was administered at a dose of 1 capsule 2 times a day for a month. Phototherapy was performed by means of MEDlight OCTAderm (3 times per week, the course of treatment - 15 procedures). After a course of phototherapy in combination with Selenium (study group), 1 patient had complete regimentation, in 43.5%of patients with NSV whisk of regimentation was formed, in 60.9% of patients with partial NSV we observeda partial regimentation in the form of pigmented inclusions withinthe foci of depigmentation. In the group of comparison we did not reveal any case of full regimentation, the whisk of hyperpigmentation was observed only in 34.7%, formation of pigmented inclusions within the foci of depigmentationwere revealed in 29.1% of cases. Thus, the phototherapy of vitiligoin combination with Selenium gives a well pronounced therapeutic effect, the clinical picture of which can be described as the following: high frequency, fast enough occurrence (2-3 months), cosmetic favorability-regimentation has uniform character without noticeable hyperkeratosis and peeling, as well as without any redness and hyperpigmentation.
authors.affiliation: Tbilisi Medical University, Department of Dermatology and Venerology; "Georgian Assotiation of Vitiligo", Tbilisi, Georgia.
authors.forename: N I
authors.initials: NI
authors.lastname: Tsiskarishvili
authors.affiliation: Tbilisi Medical University, Department of Dermatology and Venerology; "Georgian Assotiation of Vitiligo", Tbilisi, Georgia.
authors.forename: A
authors.initials: A
authors.lastname: Katsitadze
authors.affiliation: Tbilisi Medical University, Department of Dermatology and Venerology; "Georgian Assotiation of Vitiligo", Tbilisi, Georgia.
authors.forename: N V
authors.initials: NV
authors.lastname: Tsiskarishvili
authors.affiliation: Tbilisi Medical University, Department of Dermatology and Venerology; "Georgian Assotiation of Vitiligo", Tbilisi, Georgia.
authors.forename: Ts
authors.initials: T
authors.lastname: Tsiskarishvili
authors.affiliation: Tbilisi Medical University, Department of Dermatology and Venerology; "Georgian Assotiation of Vitiligo", Tbilisi, Georgia.
authors.forename: L
authors.initials: L
authors.lastname: Chitanava
mesh_terms: D000293:Adolescent; D000328:Adult; D000975:Antioxidants / Q000627:therapeutic use*; D001205:Ascorbic Acid / Q000627:therapeutic use; D002338:Carotenoids / Q000627:therapeutic use; D003131:Combined Modality Therapy; D004338:Drug Combinations; D005260:Female; D006801:Humans; D000077276:Lycopene; D008297:Male; D010789:Phototherapy; D012643:Selenium / Q000627:therapeutic use; D016896:Treatment Outcome; D014466:Ultraviolet Rays; D014810:Vitamin E / Q000627:therapeutic use; D014820:Vitiligo / Q000188:drug therapy / Q000628:therapy*; D055815:Young Adult
chemical_list: D000975:Antioxidants; D004338:Drug Combinations; D014810:Vitamin E; D002338:Carotenoids; D012643:Selenium; D001205:Ascorbic Acid; D000077276:Lycopene