title: Comparison of medication adherence in diabetes mellitus patients on human versus analogue insulins.
abstract: Objetive: This study evaluated the results of treatment adherence scales in two cohorts of patients with diabetes mellitus treated either with human or analogue insulins.
  
  
  METHODS
  A cohort study was conducted in diabetes mellitus patients older than 18 that were being treated with human or analogue insulins. Two instruments were applied to each patient [medication possession ratio, Morisky-Green test] to evaluate treatment adherence.
  
  
  RESULTS
  A total of 238 patients, were included. The majority (69.4%) of the subjects had human insulin and 30.6% had insulin analogue prescriptions. Out of the total, 163 (68.5%) cases were classified as adherent to therapy, according to the type of insulin, as follows: 69.9% for conventional and 65.3% for analogues; without differences between the groups (CI95%:0.450-1.458). The adherence to treatment was more probable in patients with elementary-secondary education (OR:2.341; CI95%:1.199-4.568) and less probable for those in the age range of 31-45 years (OR:0.427; CI95%:0.187-0.971).
  
  
  CONCLUSIONS
  The results of this study show that there are no significant statistical differences in adherence when comparing human with analogue insulin therapy. Strategies to improve treatment adherence are particularly important since they improve the clinical results.
authors.affiliation: a Grupo de Investigación en Farmacoepidemiología y Farmacovigilancia , Universidad Tecnológica de Pereira-Audifarma S.A ., Pereira , Colombia.
authors.forename: Jorge Enrique
authors.initials: JE
authors.lastname: Machado-Alba
authors.affiliation: a Grupo de Investigación en Farmacoepidemiología y Farmacovigilancia , Universidad Tecnológica de Pereira-Audifarma S.A ., Pereira , Colombia.
authors.forename: Diego Alejandro
authors.initials: DA
authors.lastname: Medina-Morales
authors.affiliation: a Grupo de Investigación en Farmacoepidemiología y Farmacovigilancia , Universidad Tecnológica de Pereira-Audifarma S.A ., Pereira , Colombia.
authors.forename: Luis Felipe
authors.initials: LF
authors.lastname: Echeverri-Cataño
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D015331:Cohort Studies; D003920:Diabetes Mellitus / Q000188:drug therapy*; D004522:Educational Status; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D007328:Insulin / Q000008:administration & dosage* / Q000031:analogs & derivatives / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D055815:Young Adult; D016903:Drug Monitoring
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin
keywords: Diabetes Mellitus; insulin; medication adherence; pharmacoepidemiology. (MeSH)