title: Role of Imaging Tools for the Diagnosis of Borderline Ovarian Tumors: A Systematic Review and Meta-Analysis.
abstract: Borderline ovarian tumors (BOTs) have a low malignant potential and occur most often in young women. Its preoperative diagnosis can improve surgical strategy and reproductive approach. This study systematically reviews the literature for the accuracy of transvaginal ultrasound (TVUS), magnetic resonance (MRI), and computed tomography (CT) in the diagnostic of BOTs. We conducted a search in PubMed/Medline of articles in English from the last 5 years and included 14 studies for systematic review, 9 of them in the meta-analysis. The pooled sensibility and specificity was respectively 77.0% and 83.0% for TVUS (5 studies) and 85% and 74% for MRI (4 studies) in differentiating benign from malignant BOTs. CT and positron emission tomography (PET)-CT techniques were heterogeneous between studies, so a meta-analysis was not performed for the 4 studies on CT and PET-CT. However, these 4 studies have also shown a high accuracy in differentiating BOTs from malignant ovarian cancers.
authors.affiliation: Department of Obstetrics and Gynecology, Hospital das Clínicas, Medical School, University of São Paulo, São Paulo, Brazil.
authors.forename: Giuliano Moysés
authors.initials: GM
authors.lastname: Borrelli
authors.affiliation: Department of Obstetrics and Gynecology, Hospital das Clínicas, Medical School, University of São Paulo, São Paulo, Brazil.
authors.forename: Leandro Accardo
authors.initials: LA
authors.lastname: de Mattos
authors.affiliation: Department of Obstetrics and Gynecology, Hospital das Clínicas, Medical School, University of São Paulo, São Paulo, Brazil.
authors.forename: Marina de Paula
authors.initials: MP
authors.lastname: Andres
authors.affiliation: Department of Obstetrics and Gynecology, Hospital das Clínicas, Medical School, University of São Paulo, São Paulo, Brazil.
authors.forename: Manoel Orlando
authors.initials: MO
authors.lastname: Gonçalves
authors.affiliation: Department of Obstetrics and Gynecology, Cleveland Clinic, Cleveland, Ohio.
authors.forename: Rosanne M
authors.initials: RM
authors.lastname: Kho
authors.affiliation: Department of Gynecology, Hospital das Clínicas, Medical School, University of São Paulo, São Paulo, Brazil. Electronic address: msabrao@mac.com.
authors.forename: Mauricio Simões
authors.initials: MS
authors.lastname: Abrão
mesh_terms: D062625:Cystadenofibroma / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000473:pathology; D049268:Positron-Emission Tomography / Q000379:methods; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods; D014463:Ultrasonography / Q000379:methods
keywords: Borderline ovarian tumors; Computed tomography; Diagnosis; MRI; PET-CT; Ultrasound