title: Correlation between CT perfusion parameters and Fuhrman grade in pTlb renal cell carcinoma.
abstract: To evaluate the correlation of CT perfusion parameters with the Fuhrman grade in pT1b (4-7 cm) renal cell carcinoma (RCC).
  
  
  
  CT perfusion imaging and Fuhrman pathological grading of pT1b RCC were performed in 48 patients (10 grade 1, 27 grade 2, 9 grade 3, and 2 grade 4). Equivalent blood volume (BVEquiv), permeability surface area product (PS), and blood flow (BF) of tumors were measured. Grade 1 and 2 were defined as low-grade group (n = 37), meanwhile high-grade group (n = 11) included grade 3 and 4. Comparisons of CT perfusion parameters and tumor size of the two different groups were performed. Correlations between CT perfusion parameters, Fuhrman grade (grade 1, 2, 3, and 4), and tumor size were assessed.
  
  
  
  PS was significantly lower in high grade than in low-grade pT1b RCC (P = 0.004). However, no significant differences were found in BVEquivand BF between the two groups (P > 0.05 for both). The optimal threshold value, sensitivity, specificity, and the area under the ROC curve for distinguishing the two groups using PS were 68.8 mL/100 g/min, 0.7, 0.8, and 0.8, respectively. Negative significant correlation was observed between PS and Fuhrman grade (r = -0.338, P = 0.019).
  
  
  
  The PS of pT1b RCC had negative significant correlation with Fuhrman grade. CT perfusion appeared to be a non-invasive means to predict high Fuhrman grade of pT1b RCC preoperatively and guide the optimal treatment for the patient.
authors.affiliation: Department of Radiology, Changhai Hospital of Shanghai, The Second Military Medical University, 168 Changhai Rd, Shanghai, 200433, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Chen
authors.affiliation: Department of Radiology, Changhai Hospital of Shanghai, The Second Military Medical University, 168 Changhai Rd, Shanghai, 200433, China.
authors.forename: Qinqin
authors.initials: Q
authors.lastname: Kang
authors.affiliation: Department of Orthopaedics, Changhai Hospital of Shanghai, The Second Military Medical University, 168 Changhai Rd, Shanghai, 200433, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wei
authors.affiliation: Department of Radiology, Changhai Hospital of Shanghai, The Second Military Medical University, 168 Changhai Rd, Shanghai, 200433, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Xu
authors.affiliation: Hunan Tumor Hospital, PET-CT Center, 582 Xianjiahu Rd, Changsha, 410013, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Ye
authors.affiliation: Department of Radiology, Changhai Hospital of Shanghai, The Second Military Medical University, 168 Changhai Rd, Shanghai, 200433, China.
authors.forename: Tiegong
authors.initials: T
authors.lastname: Wang
authors.affiliation: Department of Radiology, Changhai Hospital of Shanghai, The Second Military Medical University, 168 Changhai Rd, Shanghai, 200433, China.
authors.forename: Yayun
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Department of Radiology, Changhai Hospital of Shanghai, The Second Military Medical University, 168 Changhai Rd, Shanghai, 200433, China. JianpingLu_1959@163.com.
authors.forename: Jianping
authors.initials: J
authors.lastname: Lu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002292:Carcinoma, Renal Cell / Q000000981:diagnostic imaging* / Q000473:pathology*; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods*; D047368:Tumor Burden
keywords: Computed tomography; Fuhrman grade; Perfusion imaging; Renal cell carcinoma