title: Cross-Reactivity Between Heparin and Danaparoid Antibodies in Cardiac Surgery.
abstract: Management of heparin-induced thrombocytopenia (HIT) entails cessation of heparin and initiation of a nonheparin parenteral anticoagulant such as danaparoid. Danaparoid cross-reactivity with HIT antibodies is an uncommon complication of treatment of HIT. We report the case of confirmed HIT and in vivo cross-reactivity with danaparoid, complicating severe sepsis due to an infectious endocarditis treated by cardiac surgery.
authors.affiliation: Département Chirurgie Cardiaque, C.H.U. La Timone, APHM, Marseille, France.
authors.forename: Thibault
authors.initials: T
authors.lastname: Ronchard
authors.affiliation: Département Chirurgie Cardiaque, C.H.U. La Timone, APHM, Marseille, France; Service Cardiologie, C.H.U. La Timone, APHM, Marseille, France.
authors.forename: Erwan
authors.initials: E
authors.lastname: Salaun
authors.affiliation: Département Chirurgie Cardiaque, C.H.U. La Timone, APHM, Marseille, France.
authors.forename: Alexis
authors.initials: A
authors.lastname: Theron
authors.affiliation: Département Chirurgie Cardiaque, C.H.U. La Timone, APHM, Marseille, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Grisoli
authors.affiliation: Département Chirurgie Cardiaque, C.H.U. La Timone, APHM, Marseille, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Jaussaud
authors.affiliation: Département Chirurgie Cardiaque, C.H.U. La Timone, APHM, Marseille, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Collart
authors.affiliation: Service Cardiologie, C.H.U. La Timone, APHM, Marseille, France; Laboratoire d'Hématologie, C.H.U. La Timone, APHM, Marseille, France.
authors.forename: Gilbert
authors.initials: G
authors.lastname: Habib
authors.affiliation: Aix-Marseille Université, URMITE, UM63, CNRS 7278, Inserm U1095, Faculté de Médecine, Marseille, France; Laboratoire d'Hématologie, C.H.U. La Timone, APHM, Marseille, France. Electronic address: lcamoin@ap-hm.fr.
authors.forename: Laurence
authors.initials: L
authors.lastname: Camoin-Jau
mesh_terms: D000925:Anticoagulants / Q000276:immunology / Q000627:therapeutic use; D006348:Cardiac Surgical Procedures; D002809:Chondroitin Sulfates / Q000276:immunology* / Q000627:therapeutic use; D003429:Cross Reactions; D003871:Dermatan Sulfate / Q000276:immunology* / Q000627:therapeutic use; D006349:Heart Valve Diseases / Q000601:surgery*; D006493:Heparin / Q000009:adverse effects / Q000276:immunology*; D006497:Heparan Sulfate / Q000276:immunology* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D013921:Thrombocytopenia / Q000150:complications* / Q000276:immunology
chemical_list: D000925:Anticoagulants; D002809:Chondroitin Sulfates; D003871:Dermatan Sulfate; D006493:Heparin; D006497:Heparan Sulfate; C035838:danaparoid