title: Developmental Phases of Anticancer Screening Models.
abstract: The development of new screening models for cancer therapy is indispensable for the improvement of cancer treatment, and for the creation of alternative possibilities in the field of chemotherapy. Screening models are routinely used to reduce the cost and resources involved in anticancer drug development. The value of any screening model will ultimately be ascertained by its ability to reliably predict the clinical response. Traditional in vivo screening models have been replaced with cell-based screening assays, and these cell-based models are under constant development to better mimic in vivo conditions. In this review, the developmental phases of anticancer screening models are discussed and exemplified, including the two-dimensional, threedimensional, cancer stem cell, and non-mammalian screening models. In addition, the use of new virtual screening tools as a model for anticancer drug development is highlighted.
authors.affiliation: Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, University of Dammam, P.O. Box: 2435, Dammam 31441. Saudi Arabia.
authors.forename: Khaldoon
authors.initials: K
authors.lastname: Alsamman
authors.affiliation: Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, University of Dammam, Dammam. Saudi Arabia.
authors.forename: Omar S
authors.initials: OS
authors.lastname: El-Masry
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D004195:Disease Models, Animal; D004354:Drug Screening Assays, Antitumor / Q000379:methods*; D006801:Humans; D007109:Immunity / Q000187:drug effects; D009369:Neoplasms / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D014411:Neoplastic Stem Cells / Q000187:drug effects / Q000276:immunology / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents
keywords: Anticancer; Drosophila; Zebrafish; drug discovery; screening model; virtual screening; yeast