title: Dietary vitamin B2 intake and breast cancer risk: a systematic review and meta-analysis.
abstract: BACKGROUND
  Epidemiological studies assessing the relationship between dietary vitamin B2 and the risk of breast cancer have produced inconsistent results. Thus, we conducted this meta-analysis of epidemiologic studies to evaluate this association.
  
  
  METHODS
  We searched English-language MEDLINE publications and conducted a manual search to screen eligible articles. A random-effect model was used to pool study-specific risk estimates. Egger's linear regression test was also used to detect publication bias in meta-analysis.
  
  
  RESULTS
  In our meta-analysis, ten studies comprising totally 12,268 breast cancer patients were available in the analyses. Pooled relative risk (RR) comparing the highest to the lowest vitamin B2 intake and breast cancer incidence was 0.85 [95% confidence interval (CI) = 0.76-0.95]. No significant heterogeneity existed across the studies (P = 0.086, I2= 40.7%). No publication bias was found. The results of dose-response analysis also showed that an increment of 1 mg/day was inversely related to the risk of breast cancer (RR = 0.94; 95% CI = 0.90-0.99).
  
  
  CONCLUSIONS
  Results from our meta-analysis indicated that dietary vitamin B2 intake is weakly related to the reduced risk of breast cancer. Additional research is also necessary to further explore this association.
authors.affiliation: Department of Surgery, Changsha Hospital for Maternal and Child Health Care, Changsha, 410006, China. yu_lanting@sina.com.
authors.forename: Lanting
authors.initials: L
authors.lastname: Yu
authors.affiliation: Departments of General Surgery, The First College of Clinical Medical Science, China Three Gorges University, Yichang, 443003, China.
authors.forename: Yuyan
authors.initials: Y
authors.lastname: Tan
authors.affiliation: Departments of General Surgery, The Fourth Affiliated Hospital ZheJiang University School of Medicine, Yiwu, 322000, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhu
mesh_terms: D001943:Breast Neoplasms / Q000209:etiology / Q000517:prevention & control*; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D012256:Riboflavin / Q000008:administration & dosage*; D012306:Risk
chemical_list: D012256:Riboflavin
keywords: Breast cancer; Meta-analysis; Risk; Vitamin B2