title: Isotretinoin Use in Thick-Skinned Rhinoplasty Patients.
abstract: One of the characteristics of mestizo patients can be the thick sebaceous skin associated with a poor osteocartilaginous underlying nasal structure. In spite of using a proper structural approach where grafts and sutures are used to define the nasal tip, frequently the results are suboptimal. Surgical techniques have been described to reduce the thickness of the skin-soft tissue envelope, but these frequently give unreliable results. The monitored use of isotretinoin given orally as a complement after performing a rhinoplasty can adequately control the production of the sebaceous glands and thin the skin-subcutaneous tissue envelope in a uniform fashion without compromising the underlying bony and cartilaginous structures of the nose. Patients ideally should be treated jointly with a dermatologist and be followed closely to monitor hepatic function. Follow-up after 2 years with pre- and postoperative pictures shows improved definition of the nasal tip and dramatic improvement on sebaceous gland production.
authors.affiliation: Division of Facial Plastic Surgery, Department of Otolaryngology, Centro Medico Imbanaco, Cali, Colombia.
authors.forename: Roxana
authors.initials: R
authors.lastname: Cobo
authors.affiliation: Department of Otolaryngology, Rivas Clinic, Bogota, Colombia.
authors.forename: Liliana
authors.initials: L
authors.lastname: Vitery
mesh_terms: D000284:Administration, Oral; D003879:Dermatologic Agents / Q000494:pharmacology*; D005006:Ethnicity; D005260:Female; D006801:Humans; D015474:Isotretinoin / Q000494:pharmacology*; D008297:Male; D012189:Retrospective Studies; D012225:Rhinoplasty / Q000379:methods*; D012867:Skin / Q000033:anatomy & histology* / Q000187:drug effects; D016896:Treatment Outcome
chemical_list: D003879:Dermatologic Agents; D015474:Isotretinoin