title: MiR-200c is a cMyc-activated miRNA that promotes nasopharyngeal carcinoma by downregulating PTEN.
abstract: The c-Myc transcription factor regulates a complex transcriptional program that leads to cellular transformation by targeting a large number of protein-encoding genes and non-coding RNAs. In this study, we show that a microRNA, miR-200c, is a novel c-Myc target that promotes cellular transformation and metastasis in nasopharyngeal carcinoma. MiR-200c achieves this oncogenic effect, at least in part, by targeting and inhibiting the tumor suppressor gene PTEN (phosphatase and tensin homolog), which is a key inhibitor of the AKT kinase signaling that promotes tumorigenesis in nasopharyngeal carcinoma. Our study thus identifies cMyc-miR-200c-PTEN-AKT as a functional module that promotes cellular transformation in nasopharyngeal carcinoma.
authors.affiliation: Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, China.|Key Laboratory of Carcinogenesis of Ministry of Health, Cancer Research Institute, Central South University, Xiangya Road, Changsha, Hunan 410078, China.
authors.forename: Pan
authors.initials: P
authors.lastname: Chen
authors.affiliation: Key Laboratory of Carcinogenesis of Ministry of Health, Cancer Research Institute, Central South University, Xiangya Road, Changsha, Hunan 410078, China.|Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL33612, USA.
authors.forename: Xiaofang
authors.initials: X
authors.lastname: Guo
authors.affiliation: Key Laboratory of Carcinogenesis of Ministry of Health, Cancer Research Institute, Central South University, Xiangya Road, Changsha, Hunan 410078, China.|The Department of Laboratory Medicine, Huaihua Medical College, Huaihua, Hunan 418000, China.
authors.forename: Liming
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Carcinogenesis of Ministry of Health, Cancer Research Institute, Central South University, Xiangya Road, Changsha, Hunan 410078, China.
authors.forename: Wenling
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL33612, USA.
authors.forename: Qingyu
authors.initials: Q
authors.lastname: Zhou
authors.affiliation: Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL33612, USA.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Tian
authors.affiliation: Key Laboratory of Carcinogenesis of Ministry of Health, Cancer Research Institute, Central South University, Xiangya Road, Changsha, Hunan 410078, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, China.|Key Laboratory of Carcinogenesis of Ministry of Health, Cancer Research Institute, Central South University, Xiangya Road, Changsha, Hunan 410078, China.
authors.forename: Qianjin
authors.initials: Q
authors.lastname: Liao
authors.affiliation: Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, China.|Key Laboratory of Carcinogenesis of Ministry of Health, Cancer Research Institute, Central South University, Xiangya Road, Changsha, Hunan 410078, China.
authors.forename: Heran
authors.initials: H
authors.lastname: Wang
authors.affiliation: Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, China.|Key Laboratory of Carcinogenesis of Ministry of Health, Cancer Research Institute, Central South University, Xiangya Road, Changsha, Hunan 410078, China.
authors.forename: Guiyuan
authors.initials: G
authors.lastname: Li
authors.affiliation: Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan 410078, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Huang
authors.affiliation: Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.
authors.forename: Xiayu
authors.initials: X
authors.lastname: Li
mesh_terms: D000818:Animals; D002277:Carcinoma / Q000235:genetics / Q000473:pathology*; D002453:Cell Cycle; D045744:Cell Line, Tumor; D002465:Cell Movement; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051379:Mice; D035683:MicroRNAs / Q000235:genetics*; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000235:genetics / Q000473:pathology*; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation; D051059:PTEN Phosphohydrolase / Q000235:genetics*; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics*; D015533:Transcriptional Activation; D015854:Up-Regulation
chemical_list: C533896:MIRN200 microRNA, human; C489427:MYC protein, human; D035683:MicroRNAs; D016271:Proto-Oncogene Proteins c-myc; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human
keywords: PTEN; c-Myc; miRNA-200c; nasopharyngeal carcinoma