title: Comparison between perfusion computed tomography and dynamic contrast-enhanced magnetic resonance imaging in assessing glioblastoma microvasculature.
abstract: OBJECTIVE
  Perfusion computed tomography (PCT) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) provide independent measurements of biomarkers related to tumor perfusion. The aim of this study was to compare the two techniques in assessing glioblastoma microvasculature.
  
  
  METHODS
  Twenty-five patients diagnosed with glioblastoma (14 males and 11 females; 51±11years old, ranging from 33 to 70 years) were includede in this prospective study. All patients underwent both PCT and DCE-MRI. Imaging was performed on a 256-slice CT scanner and a 3-T MRI system. PCT yielded permeability surface-area product (PS) using deconvolution physiological models; meanwhile, DCE-MRI determined volume transfer constant (Ktrans) using the Tofts-Kermode compartment model. All cases were submitted to surgical intervention, and CD105-microvascular density (CD105-MVD) was measured in each glioblastoma specimen. Then, Spearman's correlation coefficients and Bland-Altman plots were obtained for PS, Ktransand CD105-MVD. P<0.05 was considered statistically significant.
  
  
  RESULTS
  Tumor PS and Ktransvalues were correlated with CD105-MVD (r=0.644, P<0.001; r=0.683, P<0.001). In addition, PS was correlated with Ktransin glioblastoma (r=0.931, P<0.001). Finally, Bland-Altman plots showed no significant differences between PS and Ktrans(P=0.063).
  
  
  CONCLUSIONS
  PCT and DCE-MRI measurements of glioblastoma perfusion biomarkers have similar results, suggesting that both techniques may have comparable utility. Therefore, PCT may serve as an alternative modality to DCE-MRI for the in vivo evaluation of glioblastoma microvasculature.
authors.affiliation: Department of Radiology, Affiliated Hospital of Nantong University, No. 20 Xisi Road Nantong 226001, Jiangsu, People's Republic of China. Electronic address: jzz2397@163.com.
authors.forename: Zhong Zheng
authors.initials: ZZ
authors.lastname: Jia
authors.affiliation: Department of Neurosurgery, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong 226001, Jiangsu, People's Republic of China. Electronic address: sw740104@hotmail.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Shi
authors.affiliation: Department of Neurosurgery, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong 226001, Jiangsu, People's Republic of China. Electronic address: shij_ns@163.com.
authors.forename: Jin Long
authors.initials: JL
authors.lastname: Shi
authors.affiliation: Department of Radiology, Affiliated Hospital of Nantong University, No. 20 Xisi Road Nantong 226001, Jiangsu, People's Republic of China. Electronic address: 1021121084@qq.com.
authors.forename: Dan Dan
authors.initials: DD
authors.lastname: Shen
authors.affiliation: Department of Radiology, Affiliated Hospital of Nantong University, No. 20 Xisi Road Nantong 226001, Jiangsu, People's Republic of China. Electronic address: guhongmei71@163.com.
authors.forename: Hong Mei
authors.initials: HM
authors.lastname: Gu
authors.affiliation: Department of Radiology, Affiliated Hospital of Nantong University, No. 20 Xisi Road Nantong 226001, Jiangsu, People's Republic of China. Electronic address: 56516400@qq.com.
authors.forename: Xue Jun
authors.initials: XJ
authors.lastname: Zhou
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging / Q000473:pathology; D001932:Brain Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000473:pathology; D003287:Contrast Media; D005260:Female; D005909:Glioblastoma / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D055806:Microvessels / Q000000981:diagnostic imaging* / Q000473:pathology; D008875:Middle Aged; D011446:Prospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media
keywords: Comparison; Computed tomography; Dynamic contrast-enhanced; Glioblastoma; Magnetic resonance imaging; Perfusion