title: Correlations between serum adipocytokine concentrations, disease stage, radiological status and total body fat content in the patients with primary knee osteoarthritis.
abstract: The study was designed to investigate whether serum concentrations of leptin, resistin and adiponectin in obese and normal-weight patients with primary knee osteoarthritis (OA) correlate with clinical and radiological stages of the disease and percentage of total body fat.
  
  
  
  Seventy-three patients with knee OA, divided into obese and normal-weight groups, were clinically evaluated according to the Knee Society Score (KSS), and radiologically assessed using Kellgren and Lawrence scale. The percentage of total body fat and some anthropometric data were also given. Serum leptin, resistin and adiponectin concentrations were measured by Elisa and were correlated with the clinical, radiological and anthropometric parameters.
  
  
  
  Leptin concentrations were significantly higher (p = 0.001) in the obese patients and positively correlated (R = 0.63) with radiologically assessed OA grade, but only in the normal-weight group. Resistin and adiponectin concentrations were identical in obese and normal-weight patients and negatively correlated (R = -0.41) with the clinical status of obese patients. In both groups, percentage of total body fat positively correlated (R = 0.29 and R = 0.53 for obese and normal-weight respectively) with radiologically assessed OA grade. However, no correlations were found with clinical status of the patients.
  
  
  
  It was found that in the obese patients with knee OA, increased percentage of total body fat and elevated serum leptin concentration might favour the advancement of clinical but not radiologically assessed changes in the joint structures, while in normal-weight patients it correlates only with radiologically assessed changes but does not affect to an appreciable extent the clinical status of the patients.
authors.affiliation: Department of Orthopaedics and Traumatology, Poznan University of Medical Sciences, 28 Czerwca 1956 St., 135/147, 61-545, Poznan, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Richter
authors.affiliation: Department of Orthopaedics and Traumatology, Poznan University of Medical Sciences, 28 Czerwca 1956 St., 135/147, 61-545, Poznan, Poland. doktortrzeciak@gmail.com.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Trzeciak
authors.affiliation: Faculty of Chemistry, Adam Mickiewicz University, Poznan, Poland.|Wielkopolska Centre of Advanced Technologies, Adam Mickiewicz University, Poznan, Poland.
authors.forename: Jakub Dalibor
authors.initials: JD
authors.lastname: Rybka
authors.affiliation: Greater Poland Cancer Centre, Radiobiology Laboratory, Poznan, Poland.|Department of Electroradiology, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Wiktoria
authors.initials: W
authors.lastname: Suchorska
authors.affiliation: Greater Poland Cancer Centre, Radiobiology Laboratory, Poznan, Poland.|The Postgraduate School of Molecular Medicine, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Ewelina
authors.initials: E
authors.lastname: Augustyniak
authors.affiliation: Greater Poland Cancer Centre, Radiobiology Laboratory, Poznan, Poland.|The Postgraduate School of Molecular Medicine, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Michał
authors.initials: M
authors.lastname: Lach
authors.affiliation: Department of Orthopaedics and Traumatology, Poznan University of Medical Sciences, 28 Czerwca 1956 St., 135/147, 61-545, Poznan, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Kaczmarek
authors.affiliation: Department of Orthopaedics and Traumatology, Poznan University of Medical Sciences, 28 Czerwca 1956 St., 135/147, 61-545, Poznan, Poland.
authors.forename: Jacek
authors.initials: J
authors.lastname: Kaczmarczyk
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000273:Adipose Tissue / Q000503:physiopathology*; D000368:Aged; D000886:Anthropometry; D015992:Body Mass Index; D001835:Body Weight; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007719:Knee Joint / Q000503:physiopathology; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000150:complications; D020370:Osteoarthritis, Knee / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D052243:Resistin / Q000097:blood*
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D020738:Leptin; C499624:RETN protein, human; D052243:Resistin
keywords: Adiponectin; Leptin; Obesity; Osteoarthritis; Resistin