title: Multi-template imprinted polymers for simultaneous selective solid-phase extraction of six phenolic compounds in water samples followed by determination using capillary electrophoresis.
abstract: Novel multi-template molecularly imprinted polymers (mt-MIPs) with six phenolic compounds as the template, namely phenol, 4-chlorophenol (4-CP), 2,4,6-trichlorophenol (2,4,6-TCP), 2,4-dichlorophenol (2,4-DCP), 2-chlorophenol (2-CP) and 2,6-dichlorophenol (2,6-DCP), were prepared by precipitation polymerization and used as the adsorbents of solid-phase extraction (SPE), and coupled with capillary electrophoresis (CE) for the simultaneous selective extraction, separation and determination of trace phenolic compounds in water samples. The resultant mt-MIPs exhibited uniform spherical morphology, large specific surface area and high thermal stability, and offered high selectivity towards the six template phenolic compounds. Various parameters affecting the molecularly imprinted SPE (MISPE) efficiency were investigated in detail, and excellent CE separation was realized within 7min. Good linearity was obtained in the range of 1-200μgL-1for phenol and 4-CP, and 1-300μgL-1for 2,4,6-TCP, 2,4-DCP, 2-CP and 2,6-DCP. High sensitivity was attained with low limits of detection and quantification ranging from 0.17 to 0.31μgL-1and 0.57 to 1.03μgL-1, respectively. Satisfactory recoveries for spiked reservoir water, river water, tannery wastewater and tap water samples were achieved in the range of 82.13-105.63% with relative standard deviations within 1.68-6.96%. The developed MISPE-CE method proved practically feasible for simultaneous selective extraction/enrichment, separation and sensitive determination of multiple targets in complicated aqueous matrices.
authors.affiliation: National Engineering Laboratory for Clean Technology of Leather Manufacture, Sichuan University, Chengdu 610065, China; Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China.
authors.forename: Wenhui
authors.initials: W
authors.lastname: Lu
authors.affiliation: Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Wang
authors.affiliation: Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China.
authors.forename: Xiaqing
authors.initials: X
authors.lastname: Wu
authors.affiliation: Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China.
authors.forename: Dongyan
authors.initials: D
authors.lastname: Liu
authors.affiliation: Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China.
authors.forename: Jinhua
authors.initials: J
authors.lastname: Li
authors.affiliation: Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China; School of Chemistry and Chemical Engineering, Yantai University, Yantai 264005, China. Electronic address: lxchen@yic.ac.cn.
authors.forename: Lingxin
authors.initials: L
authors.lastname: Chen
authors.affiliation: National Engineering Laboratory for Clean Technology of Leather Manufacture, Sichuan University, Chengdu 610065, China. Electronic address: zhangxinshen@126.com.
authors.forename: Xinshen
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000327:Adsorption; D011232:Chemical Precipitation; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D019075:Electrophoresis, Capillary / Q000379:methods*; D006863:Hydrogen-Ion Concentration; D008855:Microscopy, Electron, Scanning; D054802:Molecular Imprinting / Q000379:methods*; D010636:Phenols / Q000032:analysis / Q000302:isolation & purification*; D058105:Polymerization; D011108:Polymers / Q000737:chemistry*; D052616:Solid Phase Extraction / Q000379:methods*; D012997:Solvents; D017550:Spectroscopy, Fourier Transform Infrared; D014867:Water / Q000737:chemistry*
chemical_list: D010636:Phenols; D011108:Polymers; D012997:Solvents; D014867:Water
keywords: Capillary electrophoresis; Molecularly imprinted polymers; Multi-template imprinting; Phenolic compounds; Solid-phase extraction