title: An Interesting Case of Basal Cell Carcinoma with Raynaud's Phenomenon Following Chronic Arsenic Exposure.
abstract: Arsenic is commonly known to be associated with squamous cell carcinoma. Among the lesser known associations is basal cell carcinoma and even rarer is its effect on blood vessels causing peripheral vascular disease. Here we present a case of a 55 yr old man with ulceroproliferative lesions on scalp and forehead along with several hyperpigmented patches on trunk and extremities. He had symptoms suggestive of Raynaud's phenomenon that eventually led to digital gangrene. FNAC was done which was suggestive of basal cell carcinoma. On further enquiry, he was found to reside in an arsenic endemic zone and was investigated for blood arsenic level which was elevated. Punch biopsy from different lesions from body confirmed nodular basal cell carcinoma. Presently the patient has stopped drinking water from the local tubewell. On follow-up he shows improvement of Raynaud's phenomenon and skin lesions.
authors.affiliation: Department of Pathology, NRS Medical College, Kolkata, India.
authors.forename: S
authors.initials: S
authors.lastname: Gulshan
authors.affiliation: Department of Urology, Regional Institute of Medical Sciences, Imphal, India.
authors.forename: M J
authors.initials: MJ
authors.lastname: Rahman
authors.affiliation: Department of Pathology, NRS Medical College, Kolkata, India.
authors.forename: R
authors.initials: R
authors.lastname: Sarkar
authors.affiliation: Department of Pathology, NRS Medical College, Kolkata, India.
authors.forename: S
authors.initials: S
authors.lastname: Ghosh
authors.affiliation: Department of Pathology, NRS Medical College, Kolkata, India.
authors.forename: R
authors.initials: R
authors.lastname: Hazra
mesh_terms: D001151:Arsenic / Q000097:blood / Q000633:toxicity*; D001706:Biopsy; D002280:Basal Cell Carcinoma / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011928:Raynaud Disease / Q000139:chemically induced*; D012867:Skin / Q000187:drug effects / Q000473:pathology; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000473:pathology; D014874:Water Pollutants, Chemical / Q000633:toxicity*; D014881:Water Supply
chemical_list: D014874:Water Pollutants, Chemical; D001151:Arsenic
keywords: basal cell carcinoma; chronic arsenic exposure; raynaud's phenomenon.