title: Determination of serum neutrophil gelatinase-associated lipocalin at the early stage of acute pancreatitis.
abstract: OBJECTIVE
  e aim of the study was to assess the diagnostic value of serum concentrations of neutrophil gelatinase-associated lipocalin (sNGAL) for the determination of the severity of acute pancreatitis (AP) at the early stage of the disease.
  
  
  METHODS
  The study group consisted of 65 patients(34 men and 31 women),aged 62.2 ± 16.0, admitted to the Surgery Department of the District Hospital in Sucha Beskidzka, Poland, with the diagnosis of AP according to the revised Atlanta classification (2012). sNGAL was measured with ELISA at 24, 48 and 72 hours following the onset of AP symptoms. The correlations were analyzed between sNGAL and clinical, as well as laboratory parameters, used for the assessment of AP severity.
  
  
  RESULTS
  Severe AP was associated with higher sNGAL at 24, 48 and 72 hours, while moderately severe AP was associated with higher sNGAL at 48 and 72 hours as compared to mild disease. The BISAP score ≥3 during the first 24 hours of hospital stay, and the duration of hospital stay were significantly correlated with sNGAL. Also, sNGAL positively correlated with white blood cells, C-reactive protein and fibrinogen and negatively with albumin throughout the study. The diagnostic accuracy of sNGAL for the differentiation between mild AP and more severe disease was 75%, 77% and 85% at 24, 48 and 72 hours, respectively.
  
  
  CONCLUSIONS
  Serum NGAL concentrations are associated with inflammatory markers, BISAP score and the severity of AP. sNGAL may serve as an additional prognostic biomarker in the early assessment of AP severity.
authors.affiliation: Department of Anatomy, Jagiellonian University Medical College, Kraków; Surgery Department, District Hospital, Sucha Beskidzka, Poland.
authors.forename: Mateusz
authors.initials: M
authors.lastname: Sporek
authors.forename: Paulina
authors.initials: P
authors.lastname: Dumnicka
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Gala-Błądzińska
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Mazur-Laskowska
authors.forename: Jerzy
authors.initials: J
authors.lastname: Walocha
authors.forename: Piotr
authors.initials: P
authors.lastname: Ceranowicz
authors.forename: Zygmunt
authors.initials: Z
authors.lastname: Warzecha
authors.forename: Artur
authors.initials: A
authors.lastname: Dembiński
authors.forename: Marek
authors.initials: M
authors.lastname: Kuźniewski
authors.forename: Rafał
authors.initials: R
authors.lastname: Olszanecki
authors.affiliation: Department of Diagnostics, Chair of Clinical Biochemistry, Jagiellonian University Medical College, Kraków, Poland. mbkusnie@cyf-kr.edu.pl.
authors.forename: Beata
authors.initials: B
authors.lastname: Kuśnierz-Cabala
mesh_terms: D000209:Acute-Phase Proteins / Q000378:metabolism*; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D015331:Cohort Studies; D042241:Early Diagnosis; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D000071068:Lipocalin-2 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000097:blood*; D011044:Poland; D012720:Severity of Illness Index
chemical_list: D000209:Acute-Phase Proteins; D015415:Biomarkers; C489506:LCN2 protein, human; D000071068:Lipocalin-2
keywords: acute pancreatitis; neutrophil gelatinase-associated lipocalin; prognostic markers