title: Cerium oxide nanoparticles: the regenerative redox machine in bioenergetic imbalance.
abstract: Owing to their catalytic properties as reactive oxygen species scavengers, cerium oxide nanoparticles (nanoceria) have become an extremely promising candidate for medical applications, especially in the treatment of diseases where oxidative stress has been proposed as one of the main pathogenesis factors.
  
  
  
  In this work, nanoceria antioxidant power has been tested in primary cultured skin fibroblasts, derived from healthy individuals, by evaluating the mitochondrial function both in basal condition and after an oxidative insult.
  
  
  
  Combined with a clear lack of toxicity, antioxidant activity makes nanoceria promising in a wide range of clinical applications sharing the common signature of a global bioenergetic dysfunction.
authors.affiliation: Scuola Superiore Sant'Anna, The BioRobotics Institute, Viale Rinaldo Piaggio 34, 56025 Pontedera (Pisa), Italy.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Pezzini
authors.affiliation: Istituto Italiano di Tecnologia, Center for Micro-BioRobotics @SSSA, Viale Rinaldo Piaggio 34, 56025 Pontedera (Pisa), Italy.
authors.forename: Attilio
authors.initials: A
authors.lastname: Marino
authors.affiliation: CNR, Institute of Clinical Physiology, Via Moruzzi 1, 56124 Pisa, Italy.
authors.forename: Serena
authors.initials: S
authors.lastname: Del Turco
authors.affiliation: Molecular Medicine, IRCCS Stella Maris, Via dei Giacinti 3, 56128 Calambrone (Pisa), Italy.
authors.forename: Claudia
authors.initials: C
authors.lastname: Nesti
authors.affiliation: Molecular Medicine, IRCCS Stella Maris, Via dei Giacinti 3, 56128 Calambrone (Pisa), Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Doccini
authors.affiliation: Istituto Italiano di Tecnologia, Center for Nanotechnology Innovation @NEST, Piazza San Silvestro 12, 56127 Pisa, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Cappello
authors.affiliation: Istituto Italiano di Tecnologia, Center for Nanotechnology Innovation @NEST, Piazza San Silvestro 12, 56127 Pisa, Italy.
authors.forename: Mauro
authors.initials: M
authors.lastname: Gemmi
authors.affiliation: Istituto Italiano di Tecnologia, Center for Nanotechnology Innovation @NEST, Piazza San Silvestro 12, 56127 Pisa, Italy.|Scuola Normale Superiore, NEST, Piazza San Silvestro 12, 56127 Pisa, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Parlanti
authors.affiliation: Molecular Medicine, IRCCS Stella Maris, Via dei Giacinti 3, 56128 Calambrone (Pisa), Italy.
authors.forename: Filippo M
authors.initials: FM
authors.lastname: Santorelli
authors.affiliation: Istituto Italiano di Tecnologia, Center for Micro-BioRobotics @SSSA, Viale Rinaldo Piaggio 34, 56025 Pontedera (Pisa), Italy.
authors.forename: Virgilio
authors.initials: V
authors.lastname: Mattoli
authors.affiliation: Istituto Italiano di Tecnologia, Center for Micro-BioRobotics @SSSA, Viale Rinaldo Piaggio 34, 56025 Pontedera (Pisa), Italy.|Department of Mechanical & Aerospace Engineering, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, Italy.
authors.forename: Gianni
authors.initials: G
authors.lastname: Ciofani
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage* / Q000494:pharmacology*; D002478:Cells, Cultured; D002563:Cerium / Q000494:pharmacology / Q000627:therapeutic use*; D004337:Drug Carriers / Q000737:chemistry*; D004734:Energy Metabolism / Q000187:drug effects; D005260:Female; D005347:Fibroblasts / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010084:Oxidation-Reduction / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D000975:Antioxidants; D004337:Drug Carriers; D017382:Reactive Oxygen Species; D002563:Cerium; C030583:ceric oxide
keywords: bioenergetic dysfunction; cerium oxide nanoparticles; mitochondria