title: Monoolein Cubic Phase Gels and Cubosomes Doped with Magnetic Nanoparticles-Hybrid Materials for Controlled Drug Release.
abstract: Hybrid materials consisting of a monoolein lipidic cubic phase (LCP) incorporating two types of magnetic nanoparticles (NP) were designed as addressable drug delivery systems. The materials, prepared in the form of a gel, were subsequently used as a macroscopic layer modifying an electrode and, after dispersion to nanoscale, as magnetocubosomes. These two LCPs were characterized by small-angle X-ray scattering (SAXS), cross-polarized microscopy, magnetic measurements, and phase diagrams. The magnetic dopants were hydrophobic NPoleicand hydrophilic NPcitric, characterized by dynamic light scattering (DLS) and transmission electron microscopy (TEM), and their influence on the properties of the cubic phases was investigated. The removal of the anticancer drug, Doxorubicin (Dox) from the hybrid cubic phase gels was studied by electrochemical methods. The advantages of incorporating magnetic nanoparticles into the self-assembled lipid liquid crystalline phases include the ability to address the cubic phase nanoparticle containing large amounts of drug and to control the kinetics of the drug release.
authors.affiliation: Faculty of Chemistry, University of Warsaw , Pasteura 1, PL 02-093 Warsaw, Poland.
authors.forename: Monika
authors.initials: M
authors.lastname: Szlezak
authors.affiliation: Faculty of Chemistry, University of Warsaw , Pasteura 1, PL 02-093 Warsaw, Poland.
authors.forename: Dorota
authors.initials: D
authors.lastname: Nieciecka
authors.affiliation: Faculty of Chemistry, University of Warsaw , Pasteura 1, PL 02-093 Warsaw, Poland.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Joniec
authors.affiliation: Faculty of Chemistry, University of Warsaw , Pasteura 1, PL 02-093 Warsaw, Poland.
authors.forename: Marek
authors.initials: M
authors.lastname: Pękała
authors.affiliation: Faculty of Chemistry, University of Warsaw , Pasteura 1, PL 02-093 Warsaw, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Gorecka
authors.affiliation: Université de Lorraine/CNRS , SRSMC, UMR7565, Vandoeuvre-lès-Nancy CEDEX F54506, France.
authors.forename: Mélanie
authors.initials: M
authors.lastname: Emo
authors.affiliation: Université de Lorraine/CNRS , SRSMC, UMR7565, Vandoeuvre-lès-Nancy CEDEX F54506, France.
authors.forename: Marie J
authors.initials: MJ
authors.lastname: Stébé
authors.affiliation: Faculty of Chemistry, University of Warsaw , Pasteura 1, PL 02-093 Warsaw, Poland.
authors.forename: Paweł
authors.initials: P
authors.lastname: Krysiński
authors.affiliation: Faculty of Chemistry, University of Warsaw , Pasteura 1, PL 02-093 Warsaw, Poland.
authors.forename: Renata
authors.identifier: http://orcid.org/0000-0003-0058-3691
authors.initials: R
authors.lastname: Bilewicz
mesh_terms: D065546:Drug Liberation; D005782:Gels; D005989:Glycerides; D058185:Magnetite Nanoparticles; D053838:Scattering, Small Angle; D014961:X-Ray Diffraction
chemical_list: D005782:Gels; D005989:Glycerides; D058185:Magnetite Nanoparticles; C005953:monoolein
keywords: doxorubicin; lipidic cubic phase; liquid crystalline phase; magnetic nanoparticles; magnetocubosome