title: A 2-month-old boy with hemolytic anemia and reticulocytopenia following intravenous immunoglobulin therapy for Kawasaki disease: a case report and literature review.
abstract: Herein, we report a rare case of hemolytic anemia with reticulocytopenia following intravenous immunoglobulin therapy in a young infant treated for Kawasaki disease. A 2-month-old boy presented with fever lasting 3 days, conjunctival injection, strawberry tongue, erythematous edema of the hands, and macular rash, symptoms and signs suggestive of incomplete Kawasaki disease. His fever resolved 8 days after treatment with aspirin and high dose infusion of intravenous immunoglobulin. The hemoglobin and hematocrit decreased from 9.7 g/dL and 27.1% to 7.4 g/dL and 21.3%, respectively. The patient had normocytic hypochromic anemia with anisocytosis, poikilocytosis, immature neutrophils, and nucleated red blood cells. The direct antiglobulin test result was positive, and the reticulocyte count was 1.39%. The patient had an uneventful recovery. However, reticulocytopenia persisted 1 month after discharge.
authors.affiliation: Department of Pediatrics, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
authors.forename: Na Yeon
authors.initials: NY
authors.lastname: Kim
authors.affiliation: Department of Pediatrics, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
authors.forename: Joon Hwan
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Department of Pediatrics, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
authors.forename: Jin Suk
authors.initials: JS
authors.lastname: Park
authors.affiliation: Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University, Seoul, Korea.
authors.forename: Soo Hyun
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University, Seoul, Korea.
authors.forename: Yeon Kyung
authors.initials: YK
authors.lastname: Cho
authors.affiliation: Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University, Seoul, Korea.
authors.forename: Dong Hyun
authors.initials: DH
authors.lastname: Cha
authors.affiliation: Department of Pediatrics, CHA Gangnam Medical Center, CHA University, Seoul, Korea.
authors.forename: Ki Eun
authors.initials: KE
authors.lastname: Kim
authors.affiliation: Department of Laboratory Medicine, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
authors.forename: Myung Suh
authors.initials: MS
authors.lastname: Kang
authors.affiliation: Department of Pediatrics, CHA Gangnam Medical Center, CHA University, Seoul, Korea.
authors.forename: Kyung Ah
authors.initials: KA
authors.lastname: Lim
authors.affiliation: Department of Pediatrics, CHA Gangnam Medical Center, CHA University, Seoul, Korea.
authors.forename: Youn Ho
authors.initials: YH
authors.lastname: Sheen
keywords: Anemia; Hemolysis; Kawasaki disease; Reticulocytes