title: [Increased expressions of peripheral PD-1+lymphocytes and CD4+CD25+FOXP3+T cells in gastric adenocarcinoma patients].
abstract: Objective To detect the frequencies of peripheral programmed death-1+(PD-1+) lymphocytes and CD4+CD25+FOXP3+regulatory T cells in patients with gastric adenocarcinoma. Methods The study enrolled 29 patients with gastric adenocarcinoma and 29 age- and sex-matched healthy controls. Frequencies of PD-1+lymphocytes and CD4+CD25+FOXP3+regulatory T cells were detected using flow cytometry. Results The number of PD-1+lymphocytes and CD4+CD25+FOXP3+regulatory T cells in peripheral blood was higher in patients with gastric adenocarcinoma than that in the control group. Moreover, linear correlation analysis indicated a positive correlation between PD-1 expression and frequency of CD4+CD25+FOXP3+regulatory T cells in peripheral blood of the patients. Conclusion Gastric adenocarcinoma patients present with increased PD-1+lymphocytes and CD4+CD25+FOXP3+regulatory T cells in the peripheral blood.
authors.affiliation: Team of Aviation Medical Examination, Air Force General Hospital PLA, Beijing 100142; Department of General Surgery, PLA General Hospital, Beijing 100853, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of General Surgery, PLA General Hospital, Beijing 100853, China.
authors.forename: Songyan
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of General Surgery, PLA General Hospital, Beijing 100853, China.
authors.forename: Shidong
authors.initials: S
authors.lastname: Hu
authors.affiliation: Department of General Surgery, PLA General Hospital, Beijing 100853, China.
authors.forename: Guijun
authors.initials: G
authors.lastname: Zou
authors.affiliation: Department of General Surgery, PLA General Hospital, Beijing 100853, China.
authors.forename: Zilong
authors.initials: Z
authors.lastname: Hu
authors.affiliation: Department of Nursing, Peking University International Hospital, Beijing 102206, China.
authors.forename: Huahua
authors.initials: H
authors.lastname: Wei
authors.affiliation: Admission office, PLA General Hospital, Beijing 100853, China.
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of General Surgery, PLA General Hospital, Beijing 100853, China. *Corresponding author, E-mail: duxiaohui301@sina.com.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Du
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism*; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism*; D005260:Female; D051858:Forkhead Transcription Factors / Q000378:metabolism*; D006801:Humans; D053645:Interleukin-2 Receptor alpha Subunit / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D061026:Programmed Cell Death 1 Receptor / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000378:metabolism*
chemical_list: C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; C508017:IL2RA protein, human; D053645:Interleukin-2 Receptor alpha Subunit; C105992:PDCD1 protein, human; D061026:Programmed Cell Death 1 Receptor