title: Paeoniflorin Attenuated Oxidative Stress in Rat COPD Model Induced by Cigarette Smoke.
abstract: Paeoniflorin (PF), a monoterpene glucoside, might have an effect on the oxidative stress. However, the mechanism is still unknown. In this study, we made the COPD model in Sprague-Dawley (SD) rats by exposing them to the smoke of 20 cigarettes for 1 hour/day and 6 days/week, for 12 weeks, 24 weeks, or 36 weeks. Our findings suggested that smoke inhalation can trigger the oxidative stress from the very beginning. A 24-week treatment of PF especially in the dosage of 40 mg/kg·d can attenuate oxygen stress by partially quenching reactive oxygen species (ROS) and upregulating antioxidant enzymes via an Nrf2-dependent mechanism.
authors.affiliation: Department of Integrative Medicine, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai 200040, China; The Academy of Integrative Medicine of Fudan University, Shanghai 20040, China.
authors.forename: Jinpei
authors.initials: J
authors.lastname: Lin
authors.affiliation: Department of Integrative Medicine, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai 200040, China; The Academy of Integrative Medicine of Fudan University, Shanghai 20040, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Xu
authors.affiliation: Department of Integrative Medicine, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai 200040, China; The Academy of Integrative Medicine of Fudan University, Shanghai 20040, China.
authors.forename: Genfa
authors.initials: G
authors.lastname: Wang
authors.affiliation: Department of Integrative Medicine, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai 200040, China; The Academy of Integrative Medicine of Fudan University, Shanghai 20040, China.
authors.forename: Lingwen
authors.initials: L
authors.lastname: Kong
authors.affiliation: Department of Integrative Medicine, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai 200040, China; The Academy of Integrative Medicine of Fudan University, Shanghai 20040, China.
authors.forename: Qingli
authors.identifier: 0000-0001-6173-353X
authors.initials: Q
authors.lastname: Luo
authors.affiliation: Department of Integrative Medicine, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai 200040, China; The Academy of Integrative Medicine of Fudan University, Shanghai 20040, China.
authors.forename: Yvbao
authors.initials: Y
authors.lastname: Lv
authors.affiliation: Department of Integrative Medicine, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai 200040, China; The Academy of Integrative Medicine of Fudan University, Shanghai 20040, China.
authors.forename: Jiaqi
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Integrative Medicine, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai 200040, China; The Academy of Integrative Medicine of Fudan University, Shanghai 20040, China.
authors.forename: Ying
authors.identifier: 0000-0002-7519-6867
authors.initials: Y
authors.lastname: Wei
authors.affiliation: Department of Integrative Medicine, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai 200040, China; The Academy of Integrative Medicine of Fudan University, Shanghai 20040, China.
authors.forename: Lulu
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Integrative Medicine, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai 200040, China; The Academy of Integrative Medicine of Fudan University, Shanghai 20040, China.
authors.forename: Hongying
authors.identifier: 0000-0002-0614-2152
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Integrative Medicine, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai 200040, China; The Academy of Integrative Medicine of Fudan University, Shanghai 20040, China.
authors.forename: Jingcheng
authors.identifier: 0000-0002-3645-0324
authors.initials: J
authors.lastname: Dong