title: Cramp-fasciculation syndrome associated with monofocal motor neuropathy.
abstract: BACKGROUND
  Cramp-fasciculation syndrome is a peripheral nerve hyperexcitability disorder, which could be caused by inflammatory neuropathy.
  
  
  METHODS
  We describe a 51-year-old woman who presented with a 4- to 5-year history of fasciculations and painful cramping of the right thenar eminence.
  
  
  RESULTS
  Electrophysiological studies showed motor conduction block in the right median nerve between the axilla and the elbow with fasciculation potentials and cramp discharges on electromyography in the right abductor pollicis brevis muscle. High titers of serum anti-GM1 immunoglobulin M antibodies were detected.
  
  
  CONCLUSIONS
  Monofocal motor neuropathy of the right median nerve was diagnosed. Intravenous immunoglobulin treatment led to significant improvement of symptoms and signs. Although fasciculations and cramps have been reported in multifocal motor neuropathy and are considered supporting criteria for the diagnosis, the occurrence of cramp-fasciculation syndrome as the presenting feature and predominant manifestation in monofocal motor neuropathy, a variant of multifocal motor neuropathy, is unique. Muscle Nerve 56: 828-832, 2017.
authors.affiliation: Neuromuscular Reference Center, Cliniques universitaires Saint-Luc Avenue Hippocrate 10/13.11 1200 Brussels, Belgium.|Department of Neurology, University Hospitals St-Luc, University of Louvain, Brussels, Belgium.
authors.forename: Nicolas J
authors.initials: NJ
authors.lastname: Dubuisson
authors.affiliation: Department of Neurology, University Hospitals St-Luc, University of Louvain, Brussels, Belgium.
authors.forename: Vincent
authors.initials: V
authors.lastname: Van Pesch
authors.affiliation: Neuromuscular Reference Center, Cliniques universitaires Saint-Luc Avenue Hippocrate 10/13.11 1200 Brussels, Belgium.|Department of Neurology, University Hospitals St-Luc, University of Louvain, Brussels, Belgium.
authors.forename: Peter Y K
authors.initials: PYK
authors.lastname: Van Den Bergh
mesh_terms: D004576:Electromyography; D005260:Female; D006801:Humans; D008475:Median Nerve / Q000503:physiopathology*; D008875:Middle Aged; D009468:Neuromuscular Diseases / Q000175:diagnosis* / Q000503:physiopathology* / Q000628:therapy
keywords: cramp-fasciculation syndrome; monofocal motor neuropathy; motor conduction block; multifocal motor neuropathy; peripheral nerve hyperexcitability