title: Histological and Metabolic State of Dams Suckling Small Litter or MSG-Treated Pups.
abstract: Lactation is an important function that is dependent on changes in the maternal homeostasis and sustained by histological maternal adjustments. We evaluated how offspring manipulations during the lactational phase can modulate maternal morphologic aspects in the mammary gland, adipose tissue, and pancreatic islets of lactating dams. Two different models of litter-manipulation-during-lactation were used: litter sizes, small litters (SL) or normal litters (NL) and subcutaneous injections in the puppies of monosodium glutamate (MSG), or saline (CON). SL Dams and MSG Dams presented an increase in WAT content and higher plasma levels of glucose, triglycerides, and insulin, in relation to NL Dams and CON Dams, respectively. The MG of SL Dams and MSG Dams presented a high adipocyte content and reduced alveoli development and the milk of the SL Dams presented a higher calorie and triglyceride content, compared to that of the NL Dams. SL Dams presented a reduction in islet size and greater lipid droplet accumulation in BAT, in relation to NL Dams. SL Dams and MSG Dams present similar responses to offspring manipulation during lactation, resulting in changes in metabolic parameters. These alterations were associated with higher fat accumulation in BAT and changes in milk composition only in SL Dams.
authors.affiliation: Department of General Biology, University of Ponta Grossa, Ponta Grossa, PR, Brazil.
authors.forename: Claudia Regina
authors.initials: CR
authors.lastname: Capriglioni Cancian
authors.affiliation: Department of Structural and Functional Biology, University of Campinas, Campinas, SP, Brazil.
authors.forename: Nayara Carvalho
authors.identifier: 0000-0003-4436-6947
authors.initials: NC
authors.lastname: Leite
authors.affiliation: Department of General Biology, University of Ponta Grossa, Ponta Grossa, PR, Brazil.
authors.forename: Elisangela Gueiber
authors.initials: EG
authors.lastname: Montes
authors.affiliation: Department of General Biology, University of Ponta Grossa, Ponta Grossa, PR, Brazil.
authors.forename: Stefani Valeria
authors.initials: SV
authors.lastname: Fisher
authors.affiliation: Department of General Biology, University of Ponta Grossa, Ponta Grossa, PR, Brazil.
authors.forename: Leticia
authors.initials: L
authors.lastname: Waselcoski
authors.affiliation: Department of General Biology, University of Ponta Grossa, Ponta Grossa, PR, Brazil.
authors.forename: Emily Caroline
authors.initials: EC
authors.lastname: Lopes Stal
authors.affiliation: Department of General Biology, University of Ponta Grossa, Ponta Grossa, PR, Brazil.
authors.forename: Renata Zanardini
authors.initials: RZ
authors.lastname: Christoforo
authors.affiliation: Department of Physiology, University of West Parana, Cascavel, PR, Brazil.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Grassiolli
mesh_terms: D000273:Adipose Tissue / Q000033:anatomy & histology; D000818:Animals; D004285:Dogs; D005260:Female; D007515:Islets of Langerhans / Q000033:anatomy & histology; D007774:Lactation / Q000378:metabolism*; D008098:Litter Size; D008321:Mammary Glands, Animal / Q000033:anatomy & histology; D008892:Milk / Q000737:chemistry*; D012970:Sodium Glutamate / Q000008:administration & dosage*
chemical_list: D012970:Sodium Glutamate