title: Formulation and purification of therapeutic dose of90Y-labeled peptides: Some interesting radiochemistry aspects.
abstract: Yttrium-90 obtained from most of the90Sr/90Y generators contains90Sr impurity above permissible limit for human administration. A protocol has been optimized for formulation of therapeutic dose of90Y-DOTA-Tyr3-octreotate (90Y-DOTA-TATE) and removal of90Sr impurity from it. The radiochemical purity of90Y-DOTA-TATE was found to be >98% and it met the requirements for clinical use. The radiopharmaceutical was used in preliminary clinical investigation in patients with neuroendocrine tumors. This promising strategy would aid toward widespread clinical utilization of90Sr/90Y generators.
authors.affiliation: Isotope Production and Applications Division, Bhabha Atomic Research Centre, Mumbai 400085, India.
authors.forename: Rubel
authors.initials: R
authors.lastname: Chakravarty
authors.affiliation: Isotope Production and Applications Division, Bhabha Atomic Research Centre, Mumbai 400085, India. Electronic address: sudipta@barc.gov.in.
authors.forename: Sudipta
authors.initials: S
authors.lastname: Chakraborty
authors.affiliation: Isotope Production and Applications Division, Bhabha Atomic Research Centre, Mumbai 400085, India.
authors.forename: Ashutosh
authors.initials: A
authors.lastname: Dash
mesh_terms: D004339:Drug Compounding / Q000379:methods; D004340:Drug Contamination; D004355:Drug Stability; D006801:Humans; D018358:Neuroendocrine Tumors / Q000532:radiotherapy; D015282:Octreotide / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000627:therapeutic use; D009942:Organometallic Compounds / Q000302:isolation & purification* / Q000627:therapeutic use; D011854:Radiochemistry / Q000379:methods; D019275:Radiopharmaceuticals / Q000302:isolation & purification* / Q000627:therapeutic use; D013326:Strontium Radioisotopes / Q000302:isolation & purification; D015021:Yttrium Radioisotopes / Q000302:isolation & purification* / Q000627:therapeutic use
chemical_list: C539274:90Y-octreotate, DOTA(0)-Tyr(3)-Thr(8)-; D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; D013326:Strontium Radioisotopes; D015021:Yttrium Radioisotopes; C000615496:Yttrium-90; C000615490:Strontium-90; D015282:Octreotide
keywords: (90)Sr/(90)Y generator; (90)Y; DOTA-TATE; Neuroendocrine tumors; Radionuclidic purity; Therapeutic dose