title: Systemic Treatment of Adult Atopic Dermatitis: A Review.
abstract: Atopic dermatitis (AD) is a common chronic inflammatory skin disease that predominantly affects children. However, it can persist in adulthood and/or start at older ages. Due to its chronic nature and frequently occurring relapses, AD has a substantial effect on patients' quality of life, often requiring long-term systemic treatment, especially in adult patients, who are more frequently refractory to adequate topical treatment with mid- to high-potent corticosteroids and/or calcineurin inhibitors. Therefore, treatment with systemic therapies is often needed to take control of the disease, prevent exacerbations and improve quality of life. However, data regarding systemic treatment effectiveness and long-term safety in adult patients with AD are insufficient. Indeed, standardized international guidelines are lacking, and the treatment approach widely differs among diverse countries. This review focuses on the use of systemic treatments in adult AD patients analyzing published literature.
authors.affiliation: Department of Dermatology, University of Naples Federico II, Naples, Italy. mat24@libero.It.
authors.forename: Matteo
authors.initials: M
authors.lastname: Megna
authors.affiliation: Department of Dermatology, University of Naples Federico II, Naples, Italy.
authors.forename: Maddalena
authors.initials: M
authors.lastname: Napolitano
authors.affiliation: Department of Dermatology, University of Naples Federico II, Naples, Italy.
authors.forename: Cataldo
authors.initials: C
authors.lastname: Patruno
authors.affiliation: Department of Dermatology, University of Naples Federico II, Naples, Italy.
authors.forename: Alessia
authors.initials: A
authors.lastname: Villani
authors.affiliation: Department of Dermatology, University of Naples Federico II, Naples, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Balato
authors.affiliation: Department of Dermatology, University of Naples Federico II, Naples, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Monfrecola
authors.affiliation: Department of Dermatology, University of Naples Federico II, Naples, Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Ayala
authors.affiliation: Department of Dermatology, University of Naples Federico II, Naples, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Balato
keywords: Adult atopic dermatitis; Atopic dermatitis; Biologics; Systemic treatments