title: Development and characterization of a novel porous small intestine submucosa-hydroxyapatite scaffold for bone regeneration.
abstract: The fabricated small intestine submucosa (SIS) - hydroxyapatite (HAp) sponges can act as biomimetic scaffolds to be utilized in tissue engineering and regeneration. Here we developed SIS-HAp sponges and investigated their mechanical, physical and chemical characteristics using scanning electron microscopy, Fourier transformed infrared spectroscopy, uniaxial compression, porosity, and swelling testing techniques. The results demonstrated mechanical properties superior to comparable bone substitutes fabricated with similar methods. SIS-HAp scaffolds possess an interconnected macroporosity, similar to that of trabecular bone, hence presenting a novel biomaterial that may serve as a superior bone substitute and tissue scaffold.
authors.affiliation: Biomedical Engineering Department, Universidad de los Andes, Carrera 1A No. 18A - 12, Bogota, Colombia. Electronic address: ma.castilla964@uniandes.edu.co.
authors.forename: Maria Alejandra
authors.initials: MA
authors.lastname: Castilla Bolaños
authors.affiliation: Biomedical Engineering Department, Universidad de los Andes, Carrera 1A No. 18A - 12, Bogota, Colombia.
authors.forename: Josef
authors.initials: J
authors.lastname: Buttigieg
authors.affiliation: Biomedical Engineering Department, Universidad de los Andes, Carrera 1A No. 18A - 12, Bogota, Colombia.
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Briceño Triana
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology; D001861:Bone Regeneration / Q000187:drug effects; D019245:Compressive Strength; D017886:Durapatite / Q000737:chemistry*; D007413:Intestinal Mucosa / Q000737:chemistry* / Q000502:physiology; D008855:Microscopy, Electron, Scanning; D016062:Porosity; D017550:Spectroscopy, Fourier Transform Infrared; D013552:Swine; D023822:Tissue Engineering; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D017886:Durapatite
keywords: Artificial trabecular bone; Bone tissue regeneration; Hydroxyapatite; Scaffold; Small intestine submucosa