title: Cardiovascular risk and prevention in patients with head and neck cancer treated with radiotherapy.
abstract: The underlying contributors to cardiovascular disease (CVD) in patients with head and neck squamous cell carcinoma (HNSCC) are poorly characterized.
  
  
  
  Patients with HNSCC who underwent definitive or adjuvant (chemo)radiation between 2011 and 2013 were retrospectively reviewed. The 10-year risk estimates for a CVD event were calculated according to the Framingham Risk Score (FRS).
  
  
  
  One hundred fifteen patients with predominantly stage III/IV HNSCC had a median follow-up of 2 years. At diagnosis, 23% of patients had CVD. The FRS was higher among patients with laryngeal cancer versus other sites (20.5% vs 14.4%). Twenty-four percent of all patients had uncontrolled blood pressure at diagnosis. Among the patients with CVD, 41% were not taking antiplatelet therapy and 30% were not taking statin therapy. Thirty-four percent of patients without CVD had indications for initiating statin therapy.
  
  
  
  Patients with HNSCC have a high baseline CVD risk and many do not receive optimal preventive care. © 2016 Wiley Periodicals, Inc. Head Neck 39: 527-532, 2017.
authors.affiliation: Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Case Western Reserve University, Cleveland, Ohio.
authors.forename: Christian C
authors.initials: CC
authors.lastname: Okoye
authors.affiliation: Department of Neurology, University Hospitals Cleveland Medical Center, Cleveland, Ohio.|Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio.
authors.forename: Jessica
authors.initials: J
authors.lastname: Bucher
authors.affiliation: Department of Neurology, University Hospitals Cleveland Medical Center, Cleveland, Ohio.|Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio.
authors.forename: Curtis
authors.initials: C
authors.lastname: Tatsuoka
authors.affiliation: Harrington Heart and Vascular Institute, Department of Internal Medicine - Cardiology, University Hospitals, Case Western Reserve University, Cleveland, Ohio.
authors.forename: Sahil A
authors.initials: SA
authors.lastname: Parikh
authors.affiliation: Onco-Cardiology Program, and Advanced Heart Failure and Transplant Center, Harrington Heart and Vascular Institute, Department of Internal Medicine, University Hospitals, Case Western Reserve University, Cleveland, Ohio.
authors.forename: Guilherme H
authors.initials: GH
authors.lastname: Oliveira
authors.affiliation: Division of Hematology and Oncology, Department of Medicine, University Hospitals, Case Western Reserve University, Cleveland, Ohio.
authors.forename: Michael K
authors.initials: MK
authors.lastname: Gibson
authors.affiliation: Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Case Western Reserve University, Cleveland, Ohio.
authors.forename: Mitchell
authors.initials: M
authors.lastname: Machtay
authors.affiliation: Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Case Western Reserve University, Cleveland, Ohio.
authors.forename: Min
authors.initials: M
authors.lastname: Yao
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, University Hospitals Seidman Cancer Center, Case Western Reserve University, Cleveland, Ohio.
authors.forename: Chad A
authors.initials: CA
authors.lastname: Zender
authors.affiliation: Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Case Western Reserve University, Cleveland, Ohio.
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Dorth
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000175:diagnosis / Q000532:radiotherapy*; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control*; D059248:Chemoradiotherapy / Q000009:adverse effects; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000150:complications / Q000175:diagnosis / Q000532:radiotherapy*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D050397:Radiotherapy, Intensity-Modulated / Q000009:adverse effects*; D012189:Retrospective Studies; D018570:Risk Assessment; D017678:Sex Distribution; D000077195:Squamous Cell Carcinoma of Head and Neck; D013997:Time Factors
keywords: cardiovascular disease; head and neck cancer; primary prevention; radiotherapy; risk factors