title: Cardiovascular profile in postural orthostatic tachycardia syndrome and Ehlers-Danlos syndrome type III.
abstract: The cardiovascular profile of postural orthostatic tachycardia syndrome + Ehlers-Danlos syndrome hypermobility type (POTS + EDSIII) has not been described, despite suggestions that it plays a role in orthostatic intolerance. We studied nine individuals diagnosed with POTS + EDSIII and found that the arterial stiffness and cardiac profiles of patients with POTS + EDSIII were comparable to those of age- and sex-matched controls, suggesting an alternate explanation for orthostatic intolerance.
authors.affiliation: Department of Kinesiology, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada.
authors.forename: Jem L
authors.initials: JL
authors.lastname: Cheng
authors.affiliation: Department of Kinesiology, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada.
authors.forename: Jason S
authors.initials: JS
authors.lastname: Au
authors.affiliation: Division of Cardiology, Department of Medicine, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4L8, Canada.
authors.forename: Juan C
authors.initials: JC
authors.lastname: Guzman
authors.affiliation: Division of Cardiology, Department of Medicine, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4L8, Canada.
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Morillo
authors.affiliation: Department of Kinesiology, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada. macdonmj@mcmaster.ca.
authors.forename: Maureen J
authors.initials: MJ
authors.lastname: MacDonald
mesh_terms: D000328:Adult; D002320:Cardiovascular Physiological Phenomena; D004535:Ehlers-Danlos Syndrome / Q000175:diagnosis / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D054972:Postural Orthostatic Tachycardia Syndrome / Q000175:diagnosis / Q000503:physiopathology*; D059289:Vascular Stiffness / Q000502:physiology*; D014661:Vasoconstriction / Q000502:physiology; D055815:Young Adult
keywords: Cardiovascular physiology; Echocardiography; Ehlers–Danlos syndrome type III; Postural orthostatic tachycardia syndrome; Vascular stiffness