title: Interleukin-33 Expression does not Correlate with Survival of Gastric Cancer Patients.
abstract: The aim of the study was to investigate IL-33 expression in gastric cancer (GC) and its association with the clinical characteristics and the prognosis. IL-33 protein in tumor and corresponding adjacent tissues were detected by immunohistochemistry in 179 GC patients and clinical features plus prognostic value were analyzed via Pearson's chi-square test and Kaplan-Meier test in Cox proportional hazards model, respectively. IL-33 protein levels were significantly lower in tumor tissues than adjacent tissues (29.05% vs. 78.77%, χ2= 89.05, P < 0.001). The positive rate of IL-33 in the ulcerative type group was the lowest among all groups (P < 0.05). IL-33 levels were correlated with age (P = 0.025) and invasion depth (P = 0.030) while not significantly associated with the overall survival of GC patients. IL-33 expression is associated with age and invasive depth of GC patients but not an independent risk factor of prognosis.
authors.affiliation: Department of Oncology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu Province, China.|Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu Province, China.|Jiangsu Engineering Research Center for Tumor Immunotherapy, Changzhou, China.
authors.forename: Wenwei
authors.initials: W
authors.lastname: Hu
authors.affiliation: Department of Oncology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu Province, China.|Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu Province, China.|Jiangsu Engineering Research Center for Tumor Immunotherapy, Changzhou, China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Pathology, The Third Affiliated Hospital of Soochow University, Changzhou, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Pathology, The Third Affiliated Hospital of Soochow University, Changzhou, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Tan
authors.affiliation: Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu Province, China.|Jiangsu Engineering Research Center for Tumor Immunotherapy, Changzhou, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Xu
authors.affiliation: Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu Province, China.
authors.forename: Quanqin
authors.initials: Q
authors.lastname: Xie
authors.affiliation: Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu Province, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Deng
authors.affiliation: Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
authors.forename: Binfeng
authors.initials: B
authors.lastname: Lu
authors.affiliation: Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu Province, China. jiangjingting@suda.edu.cn.|Jiangsu Engineering Research Center for Tumor Immunotherapy, Changzhou, China. jiangjingting@suda.edu.cn.
authors.forename: Jingting
authors.initials: J
authors.lastname: Jiang
authors.affiliation: Department of Oncology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu Province, China. wcpjjt@163.com.
authors.forename: Changping
authors.initials: C
authors.lastname: Wu
mesh_terms: D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D000067596:Interleukin-33 / Q000378:metabolism*; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging / Q000379:methods; D011379:Prognosis; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology*
chemical_list: C506536:IL33 protein, human; D000067596:Interleukin-33
keywords: Clinical characteristics; Gastric cancer; Interleukin-33; Survival