title: A neural mass model of basal ganglia nuclei simulates pathological beta rhythm in Parkinson's disease.
abstract: An increase in beta oscillations within the basal ganglia nuclei has been shown to be associated with movement disorder, such as Parkinson's disease. The motor cortex and an excitatory-inhibitory neuronal network composed of the subthalamic nucleus (STN) and the external globus pallidus (GPe) are thought to play an important role in the generation of these oscillations. In this paper, we propose a neuron mass model of the basal ganglia on the population level that reproduces the Parkinsonian oscillations in a reciprocal excitatory-inhibitory network. Moreover, it is shown that the generation and frequency of these pathological beta oscillations are varied by the coupling strength and the intrinsic characteristics of the basal ganglia. Simulation results reveal that increase of the coupling strength induces the generation of the beta oscillation, as well as enhances the oscillation frequency. However, for the intrinsic properties of each nucleus in the excitatory-inhibitory network, the STN primarily influences the generation of the beta oscillation while the GPe mainly determines its frequency. Interestingly, describing function analysis applied on this model theoretically explains the mechanism of pathological beta oscillations.
authors.affiliation: School of Electrical Engineering and Automation, Tianjin University, 300072 Tianjin, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Liu
authors.affiliation: School of Electrical Engineering and Automation, Tianjin University, 300072 Tianjin, China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Wang
authors.affiliation: School of Electrical Engineering and Automation, Tianjin University, 300072 Tianjin, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Liu
authors.affiliation: School of Automation and Electrical Engineering, Tianjin University of Technology and Educations, 300222 Tianjin, China.
authors.forename: Huiyan
authors.initials: H
authors.lastname: Li
authors.affiliation: School of Electrical Engineering and Automation, Tianjin University, 300072 Tianjin, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Deng
authors.affiliation: Department of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, Ohio 44106, USA.
authors.forename: Chris
authors.initials: C
authors.lastname: Fietkiewicz
authors.affiliation: Department of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, Ohio 44106, USA.
authors.forename: Kenneth A
authors.initials: KA
authors.lastname: Loparo
mesh_terms: D001479:Basal Ganglia; D001611:Beta Rhythm; D005917:Globus Pallidus; D006801:Humans; D010300:Parkinson Disease; D020531:Subthalamic Nucleus