title: Combined use of ibandronate and eldecalcitol in postmenopausal Japanese women with osteoporosis.
abstract: To evaluate the effect of combined use of ibandronate and eldecalcitol for 6 to 12 months on bone mineral density (BMD) and bone strength of the proximal femur in postmenopausal Japanese women with osteoporosis.
  
  
  
  BMD and bone strength of the proximal femur were evaluated in 78 postmenopausal women (mean age, 73.6 years) who underwent treatment for osteoporosis with combined use of ibandronate and eldecalcitol for at least 6 months. BMD was measured at the lumbar spine, femoral neck, and total hip using dual-energy X-ray absorptiometry (DXA) at baseline and every 6 months thereafter. Hip structure analysis of the narrow neck and intertrochanter was performed by a radiologist using DXA images.
  
  
  
  Respectively for the lumbar spine, femoral neck, and total hip, BMD significantly increased (from baseline) by 4.54%, 2.31%, and 1.56% at 6 months and by 5.92%, 3.02%, and 2.70% at 12 months. In hip structure analysis, most parameters improved significantly. Respectively for the narrow neck and intertrochanter, BMD significantly increased (from baseline) by 2.37% and 2.71% at 6 months and by 3.46% and 3.52% at 12 months; cross-sectional area significantly increased by 1.83% and 3.39% at 6 months and by 2.91% and 3.46% at 12 months; section modulus significantly increased by 2.42% and 4.11% at 6 months and by 4.84% and 3.26% at 12 months; cortical thickness significantly increased by 2.49% and 3.33% at 6 months and by 3.73% and 3.37% at 12 months; and buckling ratio significantly decreased by 2.97% and 2.57% at 6 months and by 3.86% and 2.99% at 12 months.
  
  
  
  Combined use of ibandronate and eldecalcitol for 6 months significantly improved bone strength of the proximal femur in postmenopausal Japanese women with osteoporosis.
authors.affiliation: Kitago Orthopaedic Clinic, Sapporo, Japan & Department of Orthopaedic Surgery, Sapporo Medical University, Sapporo, Japan.
authors.forename: Junichi
authors.initials: J
authors.lastname: Takada
authors.affiliation: Wada Women's Clinic, Asahikawa, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Wada
authors.affiliation: Department of Orthopaedic Surgery, Sapporo Medical University, Sapporo, Japan.
authors.forename: Kousuke
authors.initials: K
authors.lastname: Iba
authors.affiliation: Asabu Orthopaedic Hospital, Sapporo, Japan.
authors.forename: Kouichi
authors.initials: K
authors.lastname: Sasaki
authors.affiliation: Department of Orthopaedic Surgery, Sapporo Medical University, Sapporo, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Dohke
authors.affiliation: Department of Orthopaedic Surgery, Sapporo Medical University, Sapporo, Japan.
authors.forename: Kumiko
authors.initials: K
authors.lastname: Kanaya
authors.affiliation: Kitago Orthopaedic Clinic, Sapporo, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Yoshizaki
authors.affiliation: Department of Orthopaedic Surgery, Sapporo Medical University, Sapporo, Japan.
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Yamashita
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D044466:Asian People; D015519:Bone Density; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D004164:Diphosphonates / Q000627:therapeutic use*; D005260:Female; D005269:Femur; D006801:Humans; D000077557:Ibandronic Acid; D007564:Japan; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000188:drug therapy*; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D014807:Vitamin D; C547512:eldecalcitol; D000077557:Ibandronic Acid
keywords: bone density; diphosphonates; eldecalcitol; ibandronic acid; osteoporosis, postmenopausal