title: "Helix-in-Helix" Superstructure Formation through Encapsulation of Fullerene-Bound Helical Peptides within a Helical Poly(methyl methacrylate) Cavity.
abstract: A one-handed 310-helical hexapeptide is efficiently encapsulated within the helical cavity of st-PMMA when a fullerene (C60) derivative is introduced at the C-terminal end of the peptide. The encapsulation is accompanied by induction of a preferred-handed helical conformation in the st-PMMA backbone with the same-handedness as that of the hexapeptide to form a crystalline st-PMMA/peptide-C60inclusion complex with a unique optically active helix-in-helix structure. Although the st-PMMA is unable to encapsulate the 310-helical peptide without the terminal C60unit, the helical hollow space of the st-PMMA is almost filled by the C60-bound peptides. This result suggests that the C60moiety can serve as a versatile molecular carrier of specific molecules and polymers in the helical cavity of the st-PMMA for the formation of an inclusion complex, thus producing unique supramolecular soft materials that cannot be prepared by other methods.
authors.affiliation: Department of Molecular Design and Engineering, Graduate School of Engineering, Nagoya University, Chikusa-ku, Nagoya, 464-8603, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Ousaka
authors.affiliation: Department of Molecular Design and Engineering, Graduate School of Engineering, Nagoya University, Chikusa-ku, Nagoya, 464-8603, Japan.
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Mamiya
authors.affiliation: Department of Molecular Design and Engineering, Graduate School of Engineering, Nagoya University, Chikusa-ku, Nagoya, 464-8603, Japan.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Iwata
authors.affiliation: Institute for Molecular Science, 38 Nishigo-Naka, Myodaiji, Okazaki, 444-8585, Japan.
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Nishimura
authors.affiliation: Department of Molecular Design and Engineering, Graduate School of Engineering, Nagoya University, Chikusa-ku, Nagoya, 464-8603, Japan.
authors.forename: Eiji
authors.initials: E
authors.lastname: Yashima
mesh_terms: D037741:Fullerenes / Q000737:chemistry*; D046911:Macromolecular Substances / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry*; D019904:Polymethyl Methacrylate / Q000737:chemistry*
chemical_list: D037741:Fullerenes; D046911:Macromolecular Substances; D010455:Peptides; D019904:Polymethyl Methacrylate; C069837:fullerene C60
keywords: chirality; fullerenes; helical structures; peptides; supramolecular chemistry