title: Assessment of tibial and common peroneal nerves in diabetic peripheral neuropathy by diffusion tensor imaging: a case control study.
abstract: OBJECTIVE
  To determine the diagnostic accuracy and interobserver performance of diffusion tensor imaging (DTI) in diabetic peripheral neuropathy (DPN) and detect correlations with electrophysiology.
  
  
  METHODS
  Twelve healthy volunteers (controls) and ten DPN patients were enrolled to undergo MR examinations. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values of tibial nerve (TN) and common peroneal nerve (CPN) were measured. Unpaired t test and Levene tests were performed to assess differences between the two groups. Receiver operating characteristic (ROC) analysis was performed for FA and ADC values. Pearson correlation coefficient was used to assess the correlation between DTI and electrophysiology parameters in the patient group.
  
  
  RESULTS
  The FA values of TN and CPN in the DPN group were significantly lower and ADC were higher than the control group (p < 0.05). Interobserver agreement was excellent. FA positively correlated and ADC negatively correlated with motor nerve conduction velocity (MCV) (p < 0.05). There were no significant differences between motor nerve conduction amplitude and DTI parameters (p > 0.05). Moderate diagnostic accuracy of DTI was seen in the diagnosis of DPN.
  
  
  CONCLUSIONS
  DTI demonstrates moderate diagnostic accuracy and excellent interobserver performance in the detection of DPN involving the TN and CPN. There is moderate correlation with MCV.
  
  
  CONCLUSIONS
  • FA values of TN and CPN are significantly lower in DPN. • ADC values of TN and CPN are significantly higher in DPN. • DTI demonstrates moderate diagnostic accuracy in detection of DPN. • There is excellent interobserver performance in DTI measurements. • Moderate correlation is seen between DTI parameters and MCV.
authors.affiliation: Department of MR, Shandong Medical Imaging Research Institute, Shandong University, 324, Jingwu Road, Jinan, Shandong, 250021, People's Republic of China.
authors.forename: Chao
authors.initials: C
authors.lastname: Wu
authors.affiliation: Department of MR, Shandong Medical Imaging Research Institute, Shandong University, 324, Jingwu Road, Jinan, Shandong, 250021, People's Republic of China.
authors.forename: Guangbin
authors.initials: G
authors.lastname: Wang
authors.affiliation: Department of Electromyogram, Shandong provincial Hospital Affiliated to Shandong University, Jinan, Shandong, 250021, People's Republic of China.
authors.forename: Yunxia
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of MR, Shandong Medical Imaging Research Institute, Shandong University, 324, Jingwu Road, Jinan, Shandong, 250021, People's Republic of China.
authors.forename: Wen
authors.initials: W
authors.lastname: Hao
authors.affiliation: Department of Radiology, Qilu Hospital Affiliated to Shandong University, Jinan, Shandong, 250012, People's Republic of China.
authors.forename: Lianxin
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Department of MR, Shandong Medical Imaging Research Institute, Shandong University, 324, Jingwu Road, Jinan, Shandong, 250021, People's Republic of China.
authors.forename: Xinjuan
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of MR, Shandong Medical Imaging Research Institute, Shandong University, 324, Jingwu Road, Jinan, Shandong, 250021, People's Republic of China.
authors.forename: Jinfeng
authors.initials: J
authors.lastname: Cao
authors.affiliation: Department of MR, Shandong Medical Imaging Research Institute, Shandong University, 324, Jingwu Road, Jinan, Shandong, 250021, People's Republic of China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Wang
authors.affiliation: Philips Healthcare, Shanghai, China.
authors.forename: Weibo
authors.initials: W
authors.lastname: Chen
authors.affiliation: Philips Healthcare, Shanghai, China.
authors.forename: Queenie
authors.initials: Q
authors.lastname: Chan
authors.affiliation: Department of MR, Shandong Medical Imaging Research Institute, Shandong University, 324, Jingwu Road, Jinan, Shandong, 250021, People's Republic of China. zhaobin_sdu@sina.com.
authors.forename: Bin
authors.identifier: http://orcid.org/0000-0001-6139-6561
authors.initials: B
authors.lastname: Zhao
authors.affiliation: UT southwestern Medical Center, Dallas, Tx, USA.
authors.forename: Avneesh
authors.initials: A
authors.lastname: Chhabra
mesh_terms: D000328:Adult; D000368:Aged; D016880:Anisotropy; D016022:Case-Control Studies; D003929:Diabetic Neuropathies / Q000000981:diagnostic imaging* / Q000503:physiopathology; D056324:Diffusion Tensor Imaging / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction; D015588:Observer Variation; D010523:Peripheral Nervous System Diseases / Q000000981:diagnostic imaging* / Q000503:physiopathology; D010543:Peroneal Nerve / Q000000981:diagnostic imaging*; D012372:ROC Curve; D013979:Tibial Nerve / Q000000981:diagnostic imaging*
keywords: Diabetes mellitus; Diabetic peripheral neuropathy; Diffusion tensor imaging; Electromyography; MRI