title: Near-Infrared Quantum Dot and89Zr Dual-Labeled Nanoparticles for in Vivo Cerenkov Imaging.
abstract: Cerenkov luminescence (CL) is an emerging imaging modality that utilizes the light generated during the radioactive decay of many clinical used isotopes. Although it is increasingly used for background-free imaging and deep tissue photodynamic therapy, in vivo applications of CL suffer from limited tissue penetration. Here, we propose to use quantum dots (QDs) as spectral converters that can transfer the CL UV-blue emissions to near-infrared light that is less scattered or absorbed in vivo. Experiments on tissue phantoms showed enhanced penetration depth and increased transmitted intensity for CL in the presence of near-infrared (NIR) QDs. To realize this concept for in vivo imaging applications, we developed three types of NIR QDs and89Zr dual-labeled nanoparticles based on lipid micelles, nanoemulsions, and polymeric nanoplatforms, which enable codelivery of the radionuclide and the QDs for maximized spectral conversion efficiency. We finally demonstrated the application of these self-illuminating nanoparticles for imaging of lymph nodes and tumors in a prostate cancer mouse model.
authors.affiliation: Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai , New York, New York 10029, United States.
authors.forename: Yiming
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Chemistry, Hunter College and the Graduate Center of the City University of New York , New York, New York 10065, United States.
authors.forename: Travis M
authors.initials: TM
authors.lastname: Shaffer
authors.forename: Sudeep
authors.initials: S
authors.lastname: Das
authors.affiliation: Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai , New York, New York 10029, United States.
authors.forename: Carlos
authors.initials: C
authors.lastname: Pérez-Medina
authors.affiliation: Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai , New York, New York 10029, United States.|Department of Medical Biochemistry, Academic Medical Center , Amsterdam, 1105 AZ, The Netherlands.
authors.forename: Willem J M
authors.initials: WJ
authors.lastname: Mulder
authors.affiliation: Pharmacology Program & Department of Radiology, Weill Cornell Medical College, Cornell University , New York, New York 10065, United States.
authors.forename: Jan
authors.identifier: 0000-0002-5282-9385
authors.initials: J
authors.lastname: Grimm
mesh_terms: D000818:Animals; D007259:Infrared Rays; D007554:Isotopes / Q000737:chemistry; D049449:Luminescence; D008163:Luminescent Measurements / Q000379:methods*; D008297:Male; D051379:Mice; D008819:Mice, Nude; D053758:Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000000981:diagnostic imaging*; D061848:Optical Imaging / Q000379:methods*; D045663:Quantum Dots / Q000737:chemistry*; D000071036:Sentinel Lymph Node / Q000000981:diagnostic imaging*; D015040:Zirconium / Q000737:chemistry*
chemical_list: D007554:Isotopes; D015040:Zirconium