title: Reactivation of Latent HPV Infections After Renal Transplantation.
abstract: Female renal transplant recipients (RTRs) have an increased risk for developing human papillomavirus (HPV)-related (pre)malignant lesions of the genital tract. This study aims to assess the genital prevalence of HPV before and after renal transplantation (RT). In female patients who were counseled for RT at the Radboud University Medical Center Nijmegen, the Netherlands, gynecological examination was performed at first visit, and 1 and 2 years later. HPV self-sampling and questionnaires on sexual behavior were performed every 3 months. In 65 patients who underwent RT, the high-risk human papillomavirus (hrHPV) prevalence as assessed with the highly sensitive SPF10-LiPA25test increased significantly from 19% before to 31% after RT (p = 0.045). Based upon the clinically validated Cobas 4800 HPV test, the hrHPV prevalence increased from 10% before to 14% after RT (p = 0.31). During follow-up, no changes in sexual behavior were reported. Thirty-three patients who did not undergo RT showed a hrHPV prevalence of 21% at study entry and of 27% after 12 months with the sensitive test, and a stable prevalence of 16% with the clinically validated test. The results of this study indicate that activation of latent HPV infections may contribute to the increased risk of HPV-related (pre)malignant lesions in female RTRs.
authors.affiliation: Department of Obstetrics and Gynecology, Radboud University Medical Center, Nijmegen, the Netherlands.
authors.forename: F
authors.initials: F
authors.lastname: Hinten
authors.affiliation: Department of Nephrology, Radboud University Medical Center, Nijmegen, the Netherlands.
authors.forename: L B
authors.initials: LB
authors.lastname: Hilbrands
authors.affiliation: Department of Dermatology, Radboud University Medical Center, Nijmegen, the Netherlands.
authors.forename: K A P
authors.initials: KAP
authors.lastname: Meeuwis
authors.affiliation: Department of Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: IntHout
authors.affiliation: Delft Diagnostic Laboratory, Rijswijk, the Netherlands.
authors.forename: W G V
authors.initials: WGV
authors.lastname: Quint
authors.affiliation: Department of Nephrology, Radboud University Medical Center, Nijmegen, the Netherlands.
authors.forename: A J
authors.initials: AJ
authors.lastname: Hoitsma
authors.affiliation: Department of Obstetrics and Gynecology, Radboud University Medical Center, Nijmegen, the Netherlands.
authors.forename: L F A G
authors.initials: LFAG
authors.lastname: Massuger
authors.affiliation: Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, the Netherlands.
authors.forename: W J G
authors.initials: WJG
authors.lastname: Melchers
authors.affiliation: Department of Obstetrics and Gynecology, Radboud University Medical Center, Nijmegen, the Netherlands.
authors.forename: J A
authors.initials: JA
authors.lastname: de Hullu
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006801:Humans; D007676:Kidney Failure, Chronic / Q000601:surgery / Q000821:virology*; D007677:Kidney Function Tests; D016030:Kidney Transplantation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D027383:Papillomaviridae / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000821:virology; D015995:Prevalence; D011379:Prognosis; D012307:Risk Factors; D012725:Sexual Behavior; D066027:Transplant Recipients; D014775:Virus Activation; D055815:Young Adult
keywords: cancer/malignancy/neoplasia; clinical research/practice; infection and infectious agents; kidney transplantation/nephrology; obstetrics and gynecology; preventive healthcare; viral: papillomavirus