title: Autologous bone marrow concentrate combined with platelet-rich plasma enhance bone allograft potential to induce spinal fusion.
abstract: Bone marrow cells concentrate (BMCs) is a source of osteoprogenitor cells and platelet-rich plasma (PRP) is a source of growth factors. The objective of the study was to determine whether BMC and PRP could increase the potential of bone allograft to induce posterolateral-lumbar spinal fusion compared to the bone allograft alone. A prospective nonrandomized radiographic study has been conduced on 10 patients with posterolateral instrumented fusion for degenerative lumbar disease with 1-year follow-up using CT scan. A fresh frozen bone allograft alone and bone allograft with a mixture of autologous BMC and PRP blended with thrombin were apposed in the right and left posterolateral side, respectively. CT showed good right fusion masses (allograft alone) in 4 patients and poor in 6; good left masses (BMC and PRP plus allograft) in 9 patients and poor in 1. The differences detected between right-side and left-side masses show an advantage in adding BMC and PRP to the bone allograft to increase spinal fusion rate.
authors.affiliation: Department of Orthopaedic and Trauma Surgery, Campus Bio-Medico University of Rome, Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Vadalà
authors.affiliation: Department of Orthopaedic and Trauma Surgery, Campus Bio-Medico University of Rome, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Di Martino
authors.affiliation: Department of Orthopaedic and Trauma Surgery, Campus Bio-Medico University of Rome, Rome, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Russo
authors.affiliation: Department of Transfusion Medicine and Cell Therapy, Campus Bio-Medico University of Rome, Rome, Italy.
authors.forename: M C
authors.initials: MC
authors.lastname: Tirindelli
authors.affiliation: Department of Molecular Medicine, Sapienza University, Rome, Italy.
authors.forename: L
authors.initials: L
authors.lastname: De Felice
authors.affiliation: Rome Transplant Network, Stem Cell Transplant Unit, Tor Vergata University, Rome, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Agostini
authors.affiliation: Department of Orthopaedic and Trauma Surgery, Campus Bio-Medico University of Rome, Rome, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Papalia
authors.affiliation: Department of Orthopaedic and Trauma Surgery, Campus Bio-Medico University of Rome, Rome, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Denaro
mesh_terms: D064591:Allografts; D001853:Bone Marrow; D016025:Bone Transplantation / Q000379:methods*; D006801:Humans; D008159:Lumbar Vertebrae; D053657:Platelet-Rich Plasma; D011446:Prospective Studies; D013123:Spinal Fusion / Q000379:methods*; D016896:Treatment Outcome