title: Striatal Dopaminergic Innervation Regulates Subthalamic Beta-Oscillations and Cortical-Subcortical Coupling during Movements: Preliminary Evidence in Subjects with Parkinson's Disease.
abstract: Activation of the basal ganglia has been shown during the preparation and execution of movement. However, the functional interaction of cortical and subcortical brain areas during movement and the relative contribution of dopaminergic striatal innervation remains unclear. We recorded local field potential (LFP) activity from the subthalamic nucleus (STN) and high-density electroencephalography (EEG) signals in four patients with Parkinson's disease (PD) off dopaminergic medication during a multi-joint motor task performed with their dominant and non-dominant hand. Recordings were performed by means of a fully-implantable deep brain stimulation (DBS) device at 4 months after surgery. Three patients also performed a single-photon computed tomography (SPECT) with [123I]N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)nortropane (FP-CIT) to assess striatal dopaminergic innervation. Unilateral movement execution led to event-related desynchronization (ERD) followed by a rebound after movement termination event-related synchronization (ERS) of oscillatory beta activity in the STN and primary sensorimotor cortex of both hemispheres. Dopamine deficiency directly influenced movement-related beta-modulation, with greater beta-suppression in the most dopamine-depleted hemisphere for both ipsi- and contralateral hand movements. Cortical-subcortical, but not interhemispheric subcortical coherencies were modulated by movement and influenced by striatal dopaminergic innervation, being stronger in the most dopamine-depleted hemisphere. The data are consistent with a role of dopamine in shielding subcortical structures from an excessive cortical entrapment and cross-hemispheric coupling, thus allowing fine-tuning of movement.
authors.affiliation: Department of Neurology, University Hospital and Julius-Maximilian-University Wuerzburg, Germany.
authors.forename: Andrea
authors.initials: A
authors.lastname: Canessa
authors.affiliation: Department of Neurology, University Hospital and Julius-Maximilian-University Wuerzburg, Germany.
authors.forename: Nicolò G
authors.initials: NG
authors.lastname: Pozzi
authors.affiliation: Department of Neurology, University Hospital and Julius-Maximilian-University Wuerzburg, Germany.
authors.forename: Gabriele
authors.initials: G
authors.lastname: Arnulfo
authors.affiliation: Department of Nuclear Medicine, University Hospital and Julius-Maximilian-University Wuerzburg, Germany.
authors.forename: Joachim
authors.initials: J
authors.lastname: Brumberg
authors.affiliation: Department of Neurology, University Hospital and Julius-Maximilian-University Wuerzburg, Germany.
authors.forename: Martin M
authors.initials: MM
authors.lastname: Reich
authors.affiliation: Centro Parkinson, ASST G. Pini-CTO Milan, Italy.
authors.forename: Gianni
authors.initials: G
authors.lastname: Pezzoli
authors.affiliation: Department of Physiology, Pharmacology and Neuroscience, CUNY Medical School New York, NY, USA.
authors.forename: Maria F
authors.initials: MF
authors.lastname: Ghilardi
authors.affiliation: Department of Neurosurgery, University Hospital and Julius-Maximilian-University Wuerzburg, Germany.
authors.forename: Cordula
authors.initials: C
authors.lastname: Matthies
authors.affiliation: Department of Neurology, University Hospital and Julius-Maximilian-University Wuerzburg, Germany.
authors.forename: Frank
authors.initials: F
authors.lastname: Steigerwald
authors.affiliation: Department of Neurology, University Hospital and Julius-Maximilian-University Wuerzburg, Germany.
authors.forename: Jens
authors.initials: J
authors.lastname: Volkmann
authors.affiliation: Department of Neurology, University Hospital and Julius-Maximilian-University Wuerzburg, Germany.
authors.forename: Ioannis U
authors.initials: IU
authors.lastname: Isaias
keywords: Parkinson’s disease; beta oscillations; coherence analysis; imaging; motor control; movement disorders; subthalamic nucleus