title: The Effectiveness of Anticholinergic Therapy for Overactive Bladders: Systematic Review and Meta-Analysis.
abstract: The overactive bladder (OAB) has a significant negative impact on the quality of life of patients. Antimuscarinics have become the pharmacological treatment of choice for this condition. The objective of this systematic review and meta-analysis is to examine the evidence from randomized clinical trials about the outcomes of the antimuscarinic drugs available in Brazil on OABs. We searched MEDLINE and the Cochrane Central Register of Controlled Trials from the inception of these databases through to September 2015. The primary outcome measures were the mean decrease in urge urinary incontinence episodes and the mean decrease in the frequency of micturition. The results suggest that there is a moderate to high amount of evidence supporting the benefit of using anticholinergic drugs in alleviating OAB symptoms when compared with placebo. It is still not clear whether any of the specific drugs that are available in Brazil offer advantages over the others. These drugs are associated with adverse effects (dry mouth and constipation), although they are not related to an increase in the number of withdrawals.
authors.affiliation: Urogynecology Division, Gynecology Discipline, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: Andrea Moura Rodrigues Maciel da
authors.initials: AM
authors.lastname: Fonseca
authors.affiliation: Urogynecology Division, Gynecology Discipline, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: Mariana Furtado
authors.initials: MF
authors.lastname: Meinberg
authors.affiliation: Urogynecology Division, Gynecology Discipline, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: Marilene Vale de Castro
authors.initials: MV
authors.lastname: Monteiro
authors.affiliation: Urogynecology Division, Gynecology Discipline, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: Matheus
authors.initials: M
authors.lastname: Roque
authors.affiliation: Urogynecology Division, Gynecology Discipline, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
authors.forename: Jorge Milhen
authors.initials: JM
authors.lastname: Haddad
authors.affiliation: Urogynecology Division, Gynecology Discipline, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors.forename: Rodrigo Aquino
authors.initials: RA
authors.lastname: Castro
mesh_terms: D006801:Humans; D018727:Muscarinic Antagonists / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome; D053201:Urinary Bladder, Overactive / Q000188:drug therapy*
chemical_list: D018727:Muscarinic Antagonists