title: Acute promyelocytic leukaemia with a novel translocation t(16;17)(q12;p13): a case report.
abstract: Acute promyelocytic leukaemia (APML) is characterised by the t(15;17)(q22;q21), that results in the fusion of the promyelocytic leukaemia (PML) gene at 15q22 with the retinoic acid α-receptor (RARA) gene at 17q21. The current case report describes a 13-year-old male with APML, who was negative for PML/RARA fusion signal but reported to have an atypical translocation t(16;17). To the best of our knowledge this is the first case report of APML responsive to ATRA with such a translocation.
authors.affiliation: Sheri-kashmir Institute of Medical Sciences (SKIMS), Department of Clinical Hematology, Srinagar, Jammu and Kashmir (J&K), India. bashirnusrat@ymail.
authors.forename: H
authors.initials: H
authors.lastname: Bhat
authors.forename: S
authors.initials: S
authors.lastname: Geelani
authors.forename: M
authors.initials: M
authors.lastname: Rashid
authors.forename: T
authors.initials: T
authors.lastname: Bhat
authors.forename: M
authors.initials: M
authors.lastname: Qadri
authors.forename: N
authors.initials: N
authors.lastname: Bashir N
authors.forename: F
authors.initials: F
authors.lastname: Manzoor
authors.forename: S
authors.initials: S
authors.lastname: Bhat
authors.forename: F
authors.initials: F
authors.lastname: Rather
authors.forename: J
authors.initials: J
authors.lastname: Rasool
mesh_terms: D000293:Adolescent; D002885:Chromosomes, Human, Pair 16 / Q000235:genetics*; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D015473:Leukemia, Promyelocytic, Acute / Q000235:genetics*; D008297:Male; D060888:Real-Time Polymerase Chain Reaction; D014178:Translocation, Genetic