title: [Pathophysiology of immobilization osteoporosis.]
abstract: Enhancement of bone resorption and suppression of bone formation in response to reduced mechanical stress cause rapid bone loss. pharmacotherapy for immobilization osteoporosis in motor paralysis and long-term bedrest is effective therapy. Early intervention for rapid bone loss is important for immobilization osteoporosis.
authors.affiliation: Department of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, Japan.
authors.forename: Kunitaka
authors.initials: K
authors.lastname: Menuki
authors.affiliation: Department of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, Japan.
authors.forename: Akinori
authors.initials: A
authors.lastname: Sakai
mesh_terms: D000818:Animals; D015519:Bone Density; D050071:Bone Density Conservation Agents / Q000627:therapeutic use; D004195:Disease Models, Animal; D005081:Exercise Therapy; D006801:Humans; D010024:Osteoporosis / Q000378:metabolism / Q000503:physiopathology* / Q000628:therapy
chemical_list: D050071:Bone Density Conservation Agents