title: PB@Au Core-Satellite Multifunctional Nanotheranostics for Magnetic Resonance and Computed Tomography Imaging in Vivo and Synergetic Photothermal and Radiosensitive Therapy.
abstract: To integrate multiple diagnostic and therapeutic strategies on a single particle through simple and effective methods is still challenging for nanotheranostics. Herein, we develop multifunctional nanotheranostic PB@Au core-satellite nanoparticles (CSNPs) based on Prussian blue nanoparticles (PBNPs) and gold nanoparticles (AuNPs), which are two kinds of intrinsic theranostic nanomaterials, for magnetic resonance (MR)-computed tomography (CT) imaging and synergistic photothermal and radiosensitive therapy (PTT-RT). PBNPs as cores enable T1- and T2-weighted MR contrast and strong photothermal effect, while AuNPs as satellites offer CT enhancement and radiosensitization. As revealed by both MR and CT imaging, CSNPs realized efficient tumor localization by passively targeted accumulation after intravenous injection. In vivo studies showed that CSNPs resulted in synergistic PTT-RT action to achieve almost entirely suppression of tumor growth without observable recurrence. Moreover, no obvious systemic toxicity of mice confirmed good biocompatibility of CSNPs. These results raise new possibilities for clinical nanotheranostics with multimodal diagnostic and therapeutic coalescent design.
authors.affiliation: School of Life Sciences, School of Material Science and Engineering, Tianjin University, Tianjin Engineering Center for Micro-Nano Biomaterials and Detection-Treatment Technology , Tianjin 300072, PR China.|Department of Radiology, Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital , Tianjin 300052, PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Dou
authors.affiliation: Department of Radiation Oncology and Department of Radiology, The Second Hospital of Tianjin Medical University , Tianjin 300211, PR China.
authors.forename: Xue
authors.initials: X
authors.lastname: Li
authors.affiliation: School of Life Sciences, School of Material Science and Engineering, Tianjin University, Tianjin Engineering Center for Micro-Nano Biomaterials and Detection-Treatment Technology , Tianjin 300072, PR China.
authors.forename: Weitao
authors.initials: W
authors.lastname: Yang
authors.affiliation: Department of Radiation Oncology and Department of Radiology, The Second Hospital of Tianjin Medical University , Tianjin 300211, PR China.
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Department of Radiation Oncology and Department of Radiology, The Second Hospital of Tianjin Medical University , Tianjin 300211, PR China.
authors.forename: Menglin
authors.initials: M
authors.lastname: Wu
authors.affiliation: School of Life Sciences, School of Material Science and Engineering, Tianjin University, Tianjin Engineering Center for Micro-Nano Biomaterials and Detection-Treatment Technology , Tianjin 300072, PR China.
authors.forename: Yajuan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Radiation Oncology and Department of Radiology, The Second Hospital of Tianjin Medical University , Tianjin 300211, PR China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Radiation Oncology and Department of Radiology, The Second Hospital of Tianjin Medical University , Tianjin 300211, PR China.
authors.forename: Xuening
authors.initials: X
authors.lastname: Zhang
authors.affiliation: School of Life Sciences, School of Material Science and Engineering, Tianjin University, Tianjin Engineering Center for Micro-Nano Biomaterials and Detection-Treatment Technology , Tianjin 300072, PR China.
authors.forename: Jin
authors.identifier: http://orcid.org/0000-0002-6752-8526
authors.initials: J
authors.lastname: Chang
mesh_terms: D000818:Animals; D006046:Gold; D008279:Magnetic Resonance Imaging; D053768:Metal Nanoparticles; D051379:Mice; D010789:Phototherapy; D000068936:Theranostic Nanomedicine
chemical_list: D006046:Gold
keywords: gold nanoparticles; multimodal imaging; nanotheranostics; prussian blue nanoparticles; synergistic therapy