title: Symptoms of anxiety and depression during pregnancy and their association with low birth weight in Chinese women: a nested case control study.
abstract: This study is a nested case control study from a population-based cohort study conducted in Wuhan, China. The aim is to estimate the association between symptoms of depression during pregnancy (DDP), anxiety during pregnancy(ADP), and depression with anxiety during pregnancy (DADP) and low birth weight (LBW) and to examine the extent to which preterm birth (PTB) moderates these associations. Logistic regression analyses were used to model associations between DDP, ADP, and DADP and LBW. Models were stratified by the presence or absence of PTB to examine moderating effects. From the cohort study, 2853 had a LBW baby (cases); 5457 pregnant women served as controls. Women with DDP or ADP only were not at higher risk of having a LBW baby, but DADP was associated with increased risk of LBW (crude OR 1.41, 95% CI 1.17-1.70; adjusted OR 1.29, 95% CI 1.07-1.57), and the significant association was particularly evident between DADP and LBW in PTB, but not in full-term births. Our data suggests that DADP is related to an increased risk of LBW and that this association is most present in PTBs.
authors.affiliation: Wuhan Medical and Health Center for Women and Children, 100 Hongkong Road, Wuhan, Hubei, 430015, China.
authors.forename: Shaoping
authors.initials: S
authors.lastname: Yang
authors.affiliation: Wuhan Medical and Health Center for Women and Children, 100 Hongkong Road, Wuhan, Hubei, 430015, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Yang
authors.affiliation: Wuhan Environmental Monitoring Center, 422 Xinhua Road, Wuhan, Hubei, China, 430015.
authors.forename: Shengwen
authors.initials: S
authors.lastname: Liang
authors.affiliation: College for Public Health and Social Justice, Saint Louis University, 3545 Lafayette Avenue, Saint Louis, MO, 63104, USA.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.affiliation: College for Public Health and Social Justice, Saint Louis University, 3545 Lafayette Avenue, Saint Louis, MO, 63104, USA.
authors.forename: Nancy L
authors.initials: NL
authors.lastname: Weaver
authors.affiliation: Wuhan Environmental Monitoring Center, 422 Xinhua Road, Wuhan, Hubei, China, 430015.
authors.forename: Ke
authors.initials: K
authors.lastname: Hu
authors.affiliation: Wuhan Medical and Health Center for Women and Children, 100 Hongkong Road, Wuhan, Hubei, 430015, China.
authors.forename: Ronghua
authors.initials: R
authors.lastname: Hu
authors.affiliation: College for Public Health and Social Justice, Saint Louis University, 3545 Lafayette Avenue, Saint Louis, MO, 63104, USA.
authors.forename: Edwin
authors.initials: E
authors.lastname: Trevathan
authors.affiliation: Wuhan Environmental Monitoring Center, 422 Xinhua Road, Wuhan, Hubei, China, 430015.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Huang
authors.affiliation: Wuhan Medical and Health Center for Women and Children, 100 Hongkong Road, Wuhan, Hubei, 430015, China.
authors.forename: Yiming
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Wuhan Environmental Monitoring Center, 422 Xinhua Road, Wuhan, Hubei, China, 430015.
authors.forename: Ting
authors.initials: T
authors.lastname: Yin
authors.affiliation: College for Public Health and Social Justice, Saint Louis University, 3545 Lafayette Avenue, Saint Louis, MO, 63104, USA.
authors.forename: Jen Jen
authors.initials: JJ
authors.lastname: Chang
authors.affiliation: Wuhan Medical and Health Center for Women and Children, 100 Hongkong Road, Wuhan, Hubei, 430015, China.
authors.forename: Jinzhu
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Wuhan Environmental Monitoring Center, 422 Xinhua Road, Wuhan, Hubei, China, 430015.
authors.forename: Longjiao
authors.initials: L
authors.lastname: Shen
authors.affiliation: School of Public Health, Sun Yat-Sen University, 135 Xingang Xi Road, Guangzhou, 510080, China.
authors.forename: Guanghui
authors.initials: G
authors.lastname: Dong
authors.affiliation: School of Public Health, Brown University, Providence, RI, 02912, USA.
authors.forename: Tongzhang
authors.initials: T
authors.lastname: Zheng
authors.affiliation: Tongji Medical College, Huazhong University of Science and Technology, 13 Hang Kong Road, Wuhan, Hubei, 430030, China.
authors.forename: Shunqing
authors.initials: S
authors.lastname: Xu
authors.affiliation: College for Public Health and Social Justice, Saint Louis University, 3545 Lafayette Avenue, Saint Louis, MO, 63104, USA. zqian2@slu.edu.
authors.forename: Zhengmin
authors.initials: Z
authors.lastname: Qian
authors.affiliation: Wuhan Medical and Health Center for Women and Children, 100 Hongkong Road, Wuhan, Hubei, 430015, China. mchwhzb62@126.com.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
mesh_terms: D000328:Adult; D001007:Anxiety / Q000175:diagnosis / Q000208:ethnology* / Q000523:psychology; D044466:Asian People / Q000208:ethnology / Q000706:statistics & numerical data*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D003863:Depression / Q000175:diagnosis / Q000208:ethnology* / Q000523:psychology; D005260:Female; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D011159:Population Surveillance; D011247:Pregnancy; D037841:Pregnant People / Q000208:ethnology / Q000523:psychology*; D047928:Premature Birth; D012307:Risk Factors; D055815:Young Adult
keywords: Anxiety during pregnancy; Depression during pregnancy; Low birth weight; Preterm birth