title: CHOROIDAL MORPHOLOGY IN EYES WITH POLYPOIDAL CHOROIDAL VASCULOPATHY AND NORMAL OR SUBNORMAL SUBFOVEAL CHOROIDAL THICKNESS.
abstract: OBJECTIVE
  To subsegment the choroid in patients with polypoidal choroidal vasculopathy and to determine whether the ratio of choriocapillaris/Sattler layer thickness to total choroidal thickness is decreased at sites of polypoidal pathology.
  
  
  METHODS
  Retrospective, observational, cross-sectional study. A total of 320 eyes of 305 patients with polypoidal choroidal vasculopathy were studied with optical coherence tomography and dye angiography. The ratio of choriocapillaris/Sattler layer thickness to total choroidal thickness was calculated at polypoidal lesion sites in eyes with subfoveal choroidal thickness (SFCT) ≤200 μm.
  
  
  RESULTS
  Mean SFCT was 267.7 ± 118.5 μm for the entire cohort. Mean SFCT was 151.2 ± 35.0 μm in eyes with SFCT ≤200 μm (n = 124, 39%). In this subgroup, dilated Haller vessels (pachyvessels) were identified under the site of neovascular ingrowth in 117 eyes (94%). Choroidal thickness in the pachyvessel zone was greater (213.3 ± 52.2 μm) than SFCT (P < 0.001) with a significantly lower choriocapillaris/Sattler layer to total thickness ratio (P < 0.001). Qualitative alterations of the retinal pigment epithelium were observed in 60 eyes (51%).
  
  
  CONCLUSIONS
  Eyes with normal or subnormal SFCT exhibited extrafoveal choroidal thickening at sites of polypoidal disease. The choriocapillaris and Sattler layers were attenuated at these locations, but Haller vessels were markedly dilated. These changes were topographically associated with sites of neovascular ingrowth and support the classification of polypoidal choroidal vasculopathy as a pachychoroid disorder.
authors.affiliation: *Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul; †Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, Nebraska; ‡Moorfields Eye Hospital, London, United Kingdom; §Vitreous Retina Macula Consultants of New York, New York, New York; ¶LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York; and **Department of Ophthalmology, New York University School of Medicine, New York, New York.
authors.forename: Won Ki
authors.initials: WK
authors.lastname: Lee
authors.forename: Jiwon
authors.initials: J
authors.lastname: Baek
authors.forename: Kunal K
authors.initials: KK
authors.lastname: Dansingani
authors.forename: Jae Hyung
authors.initials: JH
authors.lastname: Lee
authors.forename: K Bailey
authors.initials: KB
authors.lastname: Freund
mesh_terms: D000368:Aged; D002829:Choroid / Q000098:blood supply / Q000473:pathology*; D020256:Choroidal Neovascularization / Q000473:pathology*; D003430:Cross-Sectional Studies; D005260:Female; D005451:Fluorescein Angiography / Q000379:methods; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence