title: Metformin Attenuates Cognitive Impairments in Hypoxia-Ischemia Neonatal Rats via Improving Remyelination.
abstract: Perinatal hypoxia-ischemia (H/I) causes brain injury and myelination damage. Finding efficient methods to restore myelination is critical for the recovery of brain impairments. By applying an H/I rat model, we demonstrate that metformin (Met) treatment significantly ameliorates the loss of locomotor activity and cognition of H/I rat in the Morris water maze and open field task tests. After administration of Met to H/I rat, the proliferation of Olig2+ oligodendrocyte progenitor cells and the expression of myelin basic protein are obviously increased in the corpus callosum. Additionally, the myelin sheaths are more compact and the impairments are evidently attenuated. These data indicate that Met is beneficial for the amelioration of H/I-induced myelination and behavior deficits.
authors.affiliation: Medicine Intensive Care Unit, Xuzhou Children Hospital, Xuzhou, 221000, Jiangsu, People's Republic of China.
authors.forename: Boxiang
authors.initials: B
authors.lastname: Qi
authors.affiliation: Medicine Intensive Care Unit, Xuzhou Children Hospital, Xuzhou, 221000, Jiangsu, People's Republic of China.
authors.forename: Libao
authors.initials: L
authors.lastname: Hu
authors.affiliation: Medicine Intensive Care Unit, Xuzhou Children Hospital, Xuzhou, 221000, Jiangsu, People's Republic of China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhu
authors.affiliation: Medicine Intensive Care Unit, Xuzhou Children Hospital, Xuzhou, 221000, Jiangsu, People's Republic of China.
authors.forename: Lei
authors.initials: L
authors.lastname: Shang
authors.affiliation: Medicine Intensive Care Unit, Xuzhou Children Hospital, Xuzhou, 221000, Jiangsu, People's Republic of China.
authors.forename: Liping
authors.initials: L
authors.lastname: Sheng
authors.affiliation: Medicine Intensive Care Unit, Xuzhou Children Hospital, Xuzhou, 221000, Jiangsu, People's Republic of China.
authors.forename: Xuecheng
authors.initials: X
authors.lastname: Wang
authors.affiliation: Medicine Intensive Care Unit, Xuzhou Children Hospital, Xuzhou, 221000, Jiangsu, People's Republic of China.
authors.forename: Na
authors.initials: N
authors.lastname: Liu
authors.affiliation: Medicine Intensive Care Unit, Xuzhou Children Hospital, Xuzhou, 221000, Jiangsu, People's Republic of China.
authors.forename: Nana
authors.initials: N
authors.lastname: Wen
authors.affiliation: Xiangya Hospital of Centre-South University Pediatric Teaching and Research Section, 87 Xiangya Road, Changsha, 410008, Hunan, People's Republic of China.
authors.forename: Xiaohe
authors.initials: X
authors.lastname: Yu
authors.affiliation: Xiangya Hospital of Centre-South University Pediatric Teaching and Research Section, 87 Xiangya Road, Changsha, 410008, Hunan, People's Republic of China.
authors.forename: Qihong
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Xiangya Hospital of Centre-South University Pediatric Teaching and Research Section, 87 Xiangya Road, Changsha, 410008, Hunan, People's Republic of China. medyujiayang@126.com.
authors.forename: Yujia
authors.initials: Y
authors.lastname: Yang
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D060825:Cognitive Dysfunction / Q000378:metabolism* / Q000473:pathology / Q000517:prevention & control*; D020925:Hypoxia-Ischemia, Brain / Q000378:metabolism* / Q000473:pathology / Q000517:prevention & control*; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology; D008687:Metformin / Q000494:pharmacology / Q000627:therapeutic use*; D011897:Random Allocation; D051381:Rats; D000074586:Remyelination / Q000187:drug effects* / Q000502:physiology
chemical_list: D008687:Metformin
keywords: Cognitive deficit; Metformin; Oligodendrocyte progenitor cells; Perinatal hypoxia–ischemia