title: Histopathological features of coeliac disease in a sample of Sudanese patients.
abstract: BACKGROUND
  Coeliac disease can occur at any age but is more common in children. Its diagnosis requires correlation between clinical presentations, serological results, endoscopic findings and histopathological classification using the modified Marsh grading system. This study of coeliac disease with biopsies received in the department of histopathology at Soba University Hospital, and Fedail Hospital aimed to gain insight into the demographic profile, clinical presentations and histopathological classification of patients with coeliac disease.
  
  
  METHODS
  This was a descriptive study carried out at Soba University Hospital and Fedail Hospital during the period from January 2010-December 2013. Haematoxylin & Eosin and CD3-stained slides of small intestinal biopsies of coeliac disease patients were reviewed for various histological features (1) intraepithelial lymphocytes (IEL) count per 100 enterocytes, (2) crypt hyperplasia and (3) degree of villous atrophy. Based on the histopathological findings, the cases were categorized according to the modified Marsh classification. Demographic and clinical data were obtained from the patient request forms. The data were analyzed using Statistical Package for Social Sciences Software (SPSS).
  
  
  RESULTS
  The study included 60 patients. Their age ranged from 2 to 70 years with a mean of 19.5 years (±15.7 SD). The most common age group was below 10 years old (41.6%). Male and female are equally affected. The most common clinical presentation was chronic diarrhoea (55.0%), followed by iron deficiency anemia (41.7%). The degree of villous atrophy ranged from complete atrophy (45.0%), marked atrophy (38.3%) to mild atrophy (16.6%). Marsh grade IIIC was the most common grade. The younger age-groups had a higher prevalence of iron deficiency anaemia and higher Marsh grade.
authors.affiliation: Al Neelain University, Faculty of Medicine, Histopathology Department, Soba University Hospital, Khartoum, Sudan. mdafaallah200@gmail.com.
authors.forename: M A N
authors.initials: MA
authors.lastname: Mokhtar
authors.forename: S O
authors.initials: SO
authors.lastname: Mekki
authors.forename: H M Y
authors.initials: HM
authors.lastname: Mudawi
authors.forename: S H
authors.initials: SH
authors.lastname: Sulaiman
authors.forename: M A
authors.initials: MA
authors.lastname: Tahir
authors.forename: M A
authors.initials: MA
authors.lastname: Tigani
authors.forename: I A
authors.initials: IA
authors.lastname: Omer
authors.forename: B M
authors.initials: BM
authors.lastname: Yousif
authors.forename: I A
authors.initials: IA
authors.lastname: Fragalla
authors.forename: Z
authors.initials: Z
authors.lastname: Mohammed
authors.forename: M
authors.initials: M
authors.lastname: Dafaalla
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018798:Anemia, Iron-Deficiency / Q000209:etiology; D002446:Celiac Disease / Q000150:complications / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D003967:Diarrhea / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013397:Sudan; D055815:Young Adult