title: Sumoylation in Cellular Senescence and Aging.
abstract: Sumoylation is a reversible post-translational modification that conjugates small peptide SUMO (small ubiquitin-like modifier) to a target protein. Global protein sumoylation and expression of components in sumoylation pathway were recently found to be altered in the process of organismal aging. In addition, key factors controlling cellular senescence are known to be sumoylated. This review will summarize current information on the function of sumoylation in cellular senescence and aging.
authors.forename: L
authors.initials: L
authors.lastname: Gong
authors.forename: Q
authors.initials: Q
authors.lastname: Sun
authors.affiliation: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, #54 Xianlie South Road, Guangzhou, Guangdong 510060,. China.
authors.forename: D W-C
authors.initials: DW
authors.lastname: Li
mesh_terms: D000375:Aging / Q000235:genetics*; D016922:Cellular Senescence / Q000235:genetics*; D006801:Humans; D011499:Protein Processing, Post-Translational; D015398:Signal Transduction / Q000235:genetics*; D058207:Sumoylation / Q000235:genetics*; D025801:Ubiquitin / Q000235:genetics
chemical_list: D025801:Ubiquitin
keywords: RB; Sumoylation; aging; p53; senescence