title: Unraveling the Armor of a Killer: Evasion of Host Defenses by African Swine Fever Virus.
abstract: African swine fever is an acute hemorrhagic disease of pigs. Extensive recent spread in the Russian Federation and Eastern Europe has increased the risk to global pig production. The virus is a large DNA virus and is the only member of theAsfarviridaefamily. In pigs, the virus replicates predominantly in macrophages. We review how the virus overcomes the barriers to replication in the macrophage and the virus mechanism to inhibit key host defense pathways.
authors.affiliation: The Pirbright Institute, Ash Road Pirbright, Woking, Surrey, United Kingdom.
authors.forename: Ana Luisa
authors.initials: AL
authors.lastname: Reis
authors.affiliation: The Pirbright Institute, Ash Road Pirbright, Woking, Surrey, United Kingdom.
authors.forename: Chris
authors.initials: C
authors.lastname: Netherton
authors.affiliation: The Pirbright Institute, Ash Road Pirbright, Woking, Surrey, United Kingdom linda.dixon@pirbright.ac.uk.
authors.forename: Linda K
authors.initials: LK
authors.lastname: Dixon
mesh_terms: D000357:African Swine Fever / Q000473:pathology*; D000358:African Swine Fever Virus / Q000276:immunology* / Q000472:pathogenicity*; D000818:Animals; D054884:Host-Pathogen Interactions; D057131:Immune Evasion; D007113:Immunity, Innate; D008264:Macrophages / Q000821:virology; D013552:Swine
keywords: African swine fever; apoptosis; immune evasion; interferon; protein synthesis