title: Factors associated with changes in exposure to anticholinergic and sedative medications in elderly hospitalized patients: multicentre longitudinal study.
abstract: Elderly patients exposed to drugs with anticholinergic or sedative properties may have an increased risk of adverse events. This study aimed to assess the relationship between patient characteristics and changes of exposure to anticholinergic and sedative medications during their hospital stay.
  
  
  
  A multicentre longitudinal study was set up on hospitalized patients (aged ≥65 years) using at least one drug at admission. The primary outcome was change of exposure to anticholinergic and sedative drugs between admission and discharge. Sociodemographic characteristics of the patients, comorbidities, life habits and information about the hospital stay (origin of admission, reasons for hospitalization) were collected.
  
  
  
  The study included 337 patients (mean age, 85.4 years) with an average hospital stay of 30.1 ± 37.5 days. The drug burden index increased during the hospital stay among males (P = 0.03), patients for whom the reason for hospitalization was either a stroke (P = 0.001) or inability to stay in their own home (P = 0.001), and patients with diabetes mellitus (P = 0.009). In the adjusted model, drug burden index increased among patients hospitalized for stroke, inability to stay in their own home or post-surgery, and for patients with diabetes mellitus or hypertension.
  
  
  
  The drug management of elderly patients during hospital stays may increase exposure to anticholinergic and sedative drugs. Although the anticholinergic and sedative properties may be in relation to the therapeutic purpose, they also represent an unexpected risk. Physicians and clinical pharmacists should consider performing optimization of the drug prescriptions for patients at risk.
authors.affiliation: Centre Mémoire de Ressources et de Recherche (CMRR) de Lyon, Hôpital des Charpennes, Hospices Civils de Lyon, Villeurbanne.|Centre de Recherche Clinique-Vieillissement-Cerveau-Fragilité), Hôpital des Charpennes, Hospices Civils de Lyon, Villeurbanne.
authors.forename: V
authors.initials: V
authors.lastname: Dauphinot
authors.affiliation: Groupement Hospitalier Edouard Herriot, Service Pharmaceutique, Hospices Civils de Lyon, Lyon.
authors.forename: R
authors.initials: R
authors.lastname: Faure
authors.affiliation: Groupement Hospitalier de Gériatrie, Service Pharmaceutique, Hospices Civils de Lyon, Lyon.|ISPB - Faculté de Pharmacie de Lyon, Université Lyon 1, Lyon.
authors.forename: L
authors.initials: L
authors.lastname: Bourguignon
authors.affiliation: Groupement Hospitalier de Gériatrie, Service Pharmaceutique, Hospices Civils de Lyon, Lyon.|ISPB - Faculté de Pharmacie de Lyon, Université Lyon 1, Lyon.
authors.forename: S
authors.initials: S
authors.lastname: Goutelle
authors.affiliation: Centre Mémoire de Ressources et de Recherche (CMRR) de Lyon, Hôpital des Charpennes, Hospices Civils de Lyon, Villeurbanne.|Centre de Recherche Clinique-Vieillissement-Cerveau-Fragilité), Hôpital des Charpennes, Hospices Civils de Lyon, Villeurbanne.|U1028, INSERM, Université Lyon 1, Lyon.|UMR CNRS 5292, Centre de Recherche en Neurosciences de Lyon, Lyon.
authors.forename: P
authors.initials: P
authors.lastname: Krolak-Salmon
authors.affiliation: Centre de Recherche Clinique-Vieillissement-Cerveau-Fragilité), Hôpital des Charpennes, Hospices Civils de Lyon, Villeurbanne.|Groupement Hospitalier de Gériatrie, Service Pharmaceutique, Hospices Civils de Lyon, Lyon.|UMR CNRS 5558, Laboratoire de Biométrie et Biologie Evolutive, Université Lyon 1, Villeurbanne, France.
authors.forename: C
authors.initials: C
authors.lastname: Mouchoux
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D018680:Cholinergic Antagonists / Q000009:adverse effects* / Q000627:therapeutic use; D048909:Diabetes Complications / Q000523:psychology; D005260:Female; D006760:Hospitalization; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects* / Q000627:therapeutic use; D007902:Length of Stay; D008019:Life Style; D008137:Longitudinal Studies; D008297:Male; D018570:Risk Assessment; D012959:Socioeconomic Factors; D016896:Treatment Outcome
chemical_list: D018680:Cholinergic Antagonists; D006993:Hypnotics and Sedatives
keywords: anticholinergic drugs; hospitalization; older people; sedatives; stroke