title: Plausible Role of Acute HIV Infection Mediated Immune Activation in Causing Renal Allograft Rejection: A Case Report.
abstract: Current research states that AIDS pathogenesis has its roots in a chronic activation of immune system secondary to human immunodeficiency virus (HIV)-induced proliferation of T cells, B cells, NK cells, and macrophages. Immune activation due to acute HIV infection can be highly detrimental to allograft survival in a renal transplant recipient. In this report, we describe a 32-year-old African-American male patient who underwent a second live donor renal transplant, following which he developed acute allograft rejection coincident with newly acquired HIV seropositivity.
authors.affiliation: Department of Transplant Program, North Shore University Hospital, New York.
authors.forename: Vivek
authors.initials: V
authors.lastname: Jayaschandran
authors.affiliation: Department of Transplant Program, North Shore University Hospital, New York.
authors.forename: Prejith P
authors.initials: PP
authors.lastname: Rajendran
authors.affiliation: Department of Transplant Program, North Shore University Hospital, New York.
authors.forename: Mamata
authors.initials: M
authors.lastname: Khanal
authors.affiliation: Department of Transplant Program, North Shore University Hospital, New York.
authors.forename: Prathik
authors.initials: P
authors.lastname: Krishnan
authors.affiliation: Department of Transplant Program, North Shore University Hospital, New York.
authors.forename: Poornima
authors.initials: P
authors.lastname: Ramadas
authors.affiliation: Department of Transplant Program, North Shore University Hospital, New York.
authors.forename: Asha
authors.initials: A
authors.lastname: Alex
authors.affiliation: Department of Transplant Program, North Shore University Hospital, New York.
authors.forename: Lakshmi
authors.initials: L
authors.lastname: Nambiar
authors.affiliation: Department of Infectious Disease Medicine, North Shore University Hospital, New York.
authors.forename: David A
authors.initials: DA
authors.lastname: Hirschwerk
authors.affiliation: Department of Infectious Disease Medicine, North Shore University Hospital, New York.
authors.forename: Joseph P
authors.initials: JP
authors.lastname: McGowan
authors.affiliation: Department of Transplant Program, North Shore University Hospital, New York.
authors.forename: Nicole
authors.initials: N
authors.lastname: Ali
authors.affiliation: Department of Transplant Program, North Shore University Hospital, New York.
authors.forename: Amit
authors.initials: A
authors.lastname: Basu
authors.affiliation: Department of Transplant Program, North Shore University Hospital, New York.
authors.forename: Madhu
authors.initials: M
authors.lastname: Bhaskaran
authors.affiliation: Department of Transplant Program, North Shore University Hospital, New York.
authors.forename: Ernesto P
authors.initials: EP
authors.lastname: Molmenti
keywords: AIDS; HIV; allograft; immunosuppression; renal transplant