title: AKT capture by feline leukemia virus.
abstract: Oncogene-containing retroviruses are generated by recombination events between viral and cellular sequences, a phenomenon called "oncogene capture". The captured cellular genes, referred to as "v-onc" genes, then acquire new oncogenic properties. We report a novel feline leukemia virus (FeLV), designated "FeLV-AKT", that has captured feline c-AKT1 in feline lymphoma. FeLV-AKT contains a gag-AKT fusion gene that encodes the myristoylated Gag matrix protein and the kinase domain of feline c-AKT1, but not its pleckstrin homology domain. Therefore, it differs structurally from the v-Akt gene of murine retrovirus AKT8. AKT may be involved in the mechanisms underlying malignant diseases in cats.
authors.affiliation: Laboratory of Molecular Immunology and Infectious Disease, The United Graduate School of Veterinary Science, Yamaguchi University, 1677-1 Yoshida, Yamaguchi, 753-8515, Japan.
authors.forename: Maki
authors.initials: M
authors.lastname: Kawamura
authors.affiliation: Laboratory of Molecular Immunology and Infectious Disease, Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677-1 Yoshida, Yamaguchi, 753-8515, Japan.
authors.forename: Daigo
authors.initials: D
authors.lastname: Umehara
authors.affiliation: Laboratory of Molecular Immunology and Infectious Disease, Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677-1 Yoshida, Yamaguchi, 753-8515, Japan.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Odahara
authors.affiliation: Laboratory of Molecular Immunology and Infectious Disease, Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677-1 Yoshida, Yamaguchi, 753-8515, Japan.
authors.forename: Ariko
authors.initials: A
authors.lastname: Miyake
authors.affiliation: Laboratory of Molecular Immunology and Infectious Disease, The United Graduate School of Veterinary Science, Yamaguchi University, 1677-1 Yoshida, Yamaguchi, 753-8515, Japan.
authors.forename: Minh Ha
authors.initials: MH
authors.lastname: Ngo
authors.affiliation: Kahotechno Co., Ltd, 680-41 Iizuka, Fukuoka, 820-0067, Japan.
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Ohsato
authors.affiliation: Laboratory of Internal Medicine 2, Veterinary Medicine, Azabu University, 1-17-71, Fuchinobe, Chuou-ku, Sagamihara, Kanagawa, 252-5201, Japan.
authors.forename: Masaharu
authors.initials: M
authors.lastname: Hisasue
authors.affiliation: Department of Molecular Biology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
authors.forename: Masa-Aki
authors.initials: MA
authors.lastname: Nakaya
authors.affiliation: Laboratory of Molecular Immunology and Infectious Disease, The United Graduate School of Veterinary Science, Yamaguchi University, 1677-1 Yoshida, Yamaguchi, 753-8515, Japan.
authors.forename: Shinya
authors.initials: S
authors.lastname: Watanabe
authors.affiliation: Laboratory of Molecular Immunology and Infectious Disease, The United Graduate School of Veterinary Science, Yamaguchi University, 1677-1 Yoshida, Yamaguchi, 753-8515, Japan. kaz@yamaguchi-u.ac.jp.|Laboratory of Molecular Immunology and Infectious Disease, Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677-1 Yoshida, Yamaguchi, 753-8515, Japan. kaz@yamaguchi-u.ac.jp.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Nishigaki
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000201:enzymology / Q000235:genetics* / Q000821:virology; D002415:Cats; D005256:Leukemia Virus, Feline / Q000235:genetics* / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt / Q000235:genetics* / Q000378:metabolism; D011995:Recombination, Genetic; D012192:Retroviridae Infections / Q000201:enzymology / Q000235:genetics / Q000662:veterinary* / Q000821:virology; D014412:Tumor Virus Infections / Q000201:enzymology / Q000235:genetics / Q000662:veterinary* / Q000821:virology
chemical_list: D051057:Proto-Oncogene Proteins c-akt
keywords: FeLV v-AKT; FeLV-AKT; Transduction; c-AKT1