title: The effect of inhaled inactived Mycobacterium phlei as a treatment for asthma.
abstract: Allergic asthma is a chronic airway disorder characterized by airway inflammation, mucus hypersecretion, and airway hyperresponsiveness (AHR). A murine model of asthma was used to examine the antiasthmatic effect of inhaled inactived Mycobacterium phlei (M. phlei). AHR, neutrophil levels, eosinophil levels and levels of interleukin (IL)‑17 and IL‑23 receptor (IL‑23R) were monitored. The results demonstrated that inactivated M. phlei alleviates the IL‑17+γδT cell‑mediated immune response and attenuates airway inﬂammation and airway hyperresponsiveness in the asthmatic murine lung, partially through inhibiting the expression of IL‑23R. In conclusion, inactivated M. phlei may be an effective antiasthmatic treatment, regulating IL‑17‑producing γδT (IL‑17+γδT) cell‑mediated airway inﬂammation and airway hyperresponsiveness to relieve the symptoms of mice with asthma.
authors.affiliation: Department of Respiratory Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China.
authors.forename: Moyu
authors.initials: M
authors.lastname: Ming
authors.affiliation: Department of Respiratory Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China.
authors.forename: Chaoqian
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Respiratory Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China.
authors.forename: Zhixi
authors.initials: Z
authors.lastname: Luo
authors.affiliation: Department of Respiratory Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China.
authors.forename: Shengqiu
authors.initials: S
authors.lastname: Lv
authors.affiliation: Department of Respiratory Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China.
authors.forename: Qixiang
authors.initials: Q
authors.lastname: Sun
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D018927:Anti-Asthmatic Agents / Q000276:immunology* / Q000627:therapeutic use*; D001249:Asthma / Q000276:immunology / Q000628:therapy*; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D004195:Disease Models, Animal; D004804:Eosinophils / Q000166:cytology; D020381:Interleukin-17 / Q000378:metabolism; D008168:Lung / Q000276:immunology / Q000473:pathology; D008297:Male; D016210:Methacholine Chloride / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D008856:Microscopy, Fluorescence; D009168:Mycobacterium phlei / Q000276:immunology*; D009504:Neutrophils / Q000166:cytology; D010047:Ovalbumin / Q000276:immunology; D018123:Receptors, Interleukin / Q000378:metabolism; D015164:Vaccines, Inactivated / Q000276:immunology / Q000627:therapeutic use
chemical_list: D018927:Anti-Asthmatic Agents; C515500:IL23R protein, human; D020381:Interleukin-17; D018123:Receptors, Interleukin; D015164:Vaccines, Inactivated; D016210:Methacholine Chloride; D010047:Ovalbumin