title: The evaluation of physical properties of injection molded systems based on poly(ethylene oxide) (PEO).
abstract: The effect of product design parameters on the formation and properties of an injection molded solid dosage form consisting of poly(ethylene oxide)s (PEO) and two different active pharmaceutical ingredients (APIs) was studied. The product design parameters explored were melting temperature and the duration of melting, API loading degree and the molecular weight (Mw) of PEO. The solid form composition of the model APIs, theophylline and carbamazepine, was of specific interest, and its possible impact on the in vitro drug release behavior. Mwof PEO had the greatest impact on the release rate of both APIs. High Mwresulted in slower API release rate. Process temperature had two-fold effect with PEO 300,000g/mol. Firstly, higher process temperature transformed the crystalline part of the polymer into metastable folded form (more folded crystalline regions) and less into the more stable extended form (more extended crystalline regions), which lead to enhanced theophylline release rate. Secondly, the higher process temperature seemed to induce carbamazepine polymorphic transformation from p-monoclinic form III (carbamazepine (M)) into trigonal form II (carbamazepine (T)). The results indicated that the actual content of carbamazepine (T) affected drug release behavior more than the magnitude of transformation.
authors.affiliation: Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.
authors.forename: Jari
authors.initials: J
authors.lastname: Pajander
authors.affiliation: Laboratoire de Chimie Analytique, Département de Pharmacie, Université de Liège, Avenue de l'Hôpital 1, 4000 Liège, Belgium.
authors.forename: Alexia
authors.initials: A
authors.lastname: Rensonnet
authors.affiliation: Laboratory of Polymer Chemistry, Department of Chemistry, University of Helsinki, P.O. Box 55, 00014 HU, Finland.
authors.forename: Sami
authors.initials: S
authors.lastname: Hietala
authors.affiliation: Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.
authors.forename: Jukka
authors.initials: J
authors.lastname: Rantanen
authors.affiliation: Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark. Electronic address: stefania.baldursdottir@sund.ku.dk.
authors.forename: Stefania
authors.initials: S
authors.lastname: Baldursdottir
mesh_terms: D002152:Calorimetry, Differential Scanning; D002220:Carbamazepine / Q000737:chemistry; D002850:Chromatography, Gel; D004339:Drug Compounding / Q000379:methods*; D065546:Drug Liberation; D011092:Polyethylene Glycols / Q000737:chemistry*; D033362:Powder Diffraction; D017550:Spectroscopy, Fourier Transform Infrared; D013806:Theophylline / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D002220:Carbamazepine; D011092:Polyethylene Glycols; D013806:Theophylline
keywords: Dissolution; Hot melt processing; Injection molding; Poly(ethylene oxide) (PEO); Solid state transformation