title: Synthesis and Biological Evaluation of Triazole linked Thiazolidenone Glycosides.
abstract: In a one pot procedure a series of novel triazole linked thiazolidinone derivatives 8a-g and 9a-g was prepared by condensation of (3aR,5S,6R,6aR)-6-((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-2,2-dimethyltetrahydro[2,3-d] [1,3]dioxole-5-carbaldehyde 7 with mercapto acids and primary amines in the presence of ZnCl2 under both microwave irradiation and conventional heating conditions. Compound 7 was prepared from diacetone D-glucose with oxidation followed by reduction, click reaction, primary acetonide deprotection and with oxidative cleavage. Characterization of new compounds has been done by means of IR, NMR, MS and elemental analysis. The nematicidal and antibacterial activity of the compounds has also been evaluated.
authors.forename: Srinivas
authors.initials: S
authors.lastname: Avula
authors.forename: Santhosh
authors.initials: S
authors.lastname: Madavarapu
authors.forename: Sunitha
authors.initials: S
authors.lastname: Malladi
authors.forename: Karthik
authors.initials: K
authors.lastname: Pulluri
authors.forename: Srinivas
authors.initials: S
authors.lastname: Kontham
authors.forename: Reddy K
authors.initials: RK
authors.lastname: Vasumathi
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D006027:Glycosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D009348:Nematoda / Q000187:drug effects; D013055:Spectrophotometry, Infrared; D053778:Thiazolidines / Q000737:chemistry*; D014230:Triazoles / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D006027:Glycosides; D053778:Thiazolidines; D014230:Triazoles