title: Thyroid hormone level is associated with the frequency and severity of Guillain-Barré syndrome.
abstract: OBJECTIVE
  Guillain-Barré syndrome (GBS) is a neurodegenerative and inflammatory demyelination disorder, and oxidative stress is concerned with the pathogenesis of the disease. Also, we found that thyroid hormone level is correlated to the oxidative and antioxidant status in previous studies. Our study was aimed to find the possible relationship between the frequency and severity of GBS and thyroid hormone levels.
  
  
  METHODS
  We measured serum levels of thyroid-stimulating hormone (TSH), free thyroxine (FT4) and free triiodothyronine (FT3) in 238 individuals, including 90 GBS, 44 multiple sclerosis and 104 healthy controls.
  
  
  RESULTS
  Our findings demonstrate that the patients with GBS had lower TSH and higher FT4,FT4/FT3than healthy controls in the normal range. Furthermore, it was also shown in our study that TSH levels in patients with GBS were correlated with disease severity measured by the Hughes Functional Grading Scale.
  
  
  CONCLUSIONS
  Lower TSH, higher FT4and FT4/FT3stand for the oxidative status and are associated with the incidence and severity of GBS.
authors.affiliation: a Department of Neurology , The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Huang
authors.affiliation: b Department of Respiratory and Critical Care Medicine , The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.
authors.forename: Zhaojian
authors.initials: Z
authors.lastname: Ying
authors.affiliation: a Department of Neurology , The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.
authors.forename: Zhibo
authors.initials: Z
authors.lastname: Chen
authors.affiliation: a Department of Neurology , The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Xiang
authors.affiliation: a Department of Neurology , The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.
authors.forename: Zhongqian
authors.initials: Z
authors.lastname: Su
authors.affiliation: a Department of Neurology , The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Quan
authors.affiliation: a Department of Neurology , The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.
authors.forename: Yiyun
authors.initials: Y
authors.lastname: Weng
authors.affiliation: a Department of Neurology , The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.
authors.forename: Xu
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D020275:Guillain-Barre Syndrome / Q000097:blood / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood / Q000175:diagnosis; D012720:Severity of Illness Index; D013960:Thyroid Function Tests; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000097:blood*; D014284:Triiodothyronine / Q000097:blood*
chemical_list: D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine
keywords: FT4; FT4/FT3; Guillain–Barré syndrome; TSH; oxidative stress