title: Association of MRI-classified subventricular regions with survival outcomes in patients with anaplastic glioma.
abstract: OBJECTIVE
  To investigate the prognostic role of subventricular zone (SVZ) involvement in anaplastic glioma.
  
  
  METHODS
  The magnetic resonance imaging and clinical data of 160 patients with histopathologically confirmed anaplastic glioma treated at Beijing Tiantan hospital were retrospectively reviewed. The relationship between survival and the region of the SVZ involved was determined via univariate and multivariate analysis.
  
  
  RESULTS
  In the univariate analysis, SVZ involvement significantly correlated with progression-free survival (p=0.021) and overall survival (p<0.001). Multivariate analysis showed that SVZ involvement was an independent prognostic factor for unfavourable survival (p=0.016 for overall survival), as was the involvement of the occipital horn of the SVZ (p<0.001 for progression-free survival, and p=0.016 for overall survival).
  
  
  CONCLUSIONS
  The current study shows that SVZ involvement is a valid prognostic indicator in anaplastic glioma. It is associated with worse prognosis in patients with anaplastic gliomas, particularly those with tumours invading the occipital horn of the SVZ.
authors.affiliation: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
authors.forename: S
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
authors.forename: X
authors.initials: X
authors.lastname: Fan
authors.affiliation: Department of Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
authors.forename: J
authors.initials: J
authors.lastname: Ma
authors.affiliation: Department of Radiation Oncology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. Electronic address: ttyy6611@126.com.
authors.forename: X
authors.initials: X
authors.lastname: Qiu
authors.affiliation: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Beijing Neurosurgical Institute, Capital Medical University, Beijing, China; Center of Brain Tumour, Beijing Institute for Brain Disorders, Beijing, China. Electronic address: taojiang1964@163.com.
authors.forename: T
authors.initials: T
authors.lastname: Jiang
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D018572:Disease-Free Survival; D005260:Female; D005910:Glioma / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D011379:Prognosis; D015203:Reproducibility of Results; D012189:Retrospective Studies; D055815:Young Adult