title: Family history of diabetes and the risk of gestational diabetes mellitus in Iran: A systematic review and meta-analysis.
abstract: OBJECTIVE
  Gestational diabetes is the most prevalent metabolic disorder being firstly diagnosed during pregnancy. The relationship between the family history of diabetes and the gestational diabetes mellitus (GDM) has been investigated in several primary studies with a number of contradictions in the results. Hence, the purpose of the present study is to determine the relationship between the GDM and the family history of diabetes using the meta-analysis method.
  
  
  METHODS
  All published papers in main national and international databases were systematically searched with some specific keywords to find the related studies between 2000 and 2016. We calculated the odds ratio (OR) with 95% confidence interval (CI) in analysis for each study using a random-effect and Mantel-Haenzel method. We also determined heterogeneity among these 33 articles and their publication bias.
  
  
  RESULTS
  We entered 33 relevant studies of 2516 articles into the meta-analysis process including 2697 women with family history of diabetes mellitus as well as 29134 women without. Of them, 954 and 4372 subjects developed GDM respectively. Combining the results of the primary studies using the meta-analysis method, the overall odds ratio of family history for developing GDM was estimated as of 3.46 (95% CI: 2.80-4.27).
  
  
  CONCLUSIONS
  This meta-analysis study revealed that the family history of diabetes is an important risk factor for the gestational diabetes mellitus.
authors.affiliation: Health Sciences Research Center, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran.
authors.forename: Mahmood
authors.initials: M
authors.lastname: Moosazadeh
authors.affiliation: Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.
authors.forename: Zatollah
authors.initials: Z
authors.lastname: Asemi
authors.affiliation: Health Policy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Kamran B
authors.initials: KB
authors.lastname: Lankarani
authors.affiliation: Health Policy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Tabrizi
authors.affiliation: Health Policy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Najmeh
authors.initials: N
authors.lastname: Maharlouei
authors.affiliation: Physiology Research Center, Institute of Neuropharmacology,Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Naghibzadeh-Tahami
authors.affiliation: Cardiovascular Research Center, Institute of Neuropharmacology, Kerman, Iran.
authors.forename: Gholamreza
authors.initials: G
authors.lastname: Yousefzadeh
authors.affiliation: Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Sadeghi
authors.affiliation: Torbat Heydariyeh University of Medical Sciences Torbat Heydariyeh, Iran.
authors.forename: Seyed Reza
authors.initials: SR
authors.lastname: Khatibi
authors.affiliation: Faculty of Medicine, Zabol University of Medical Sciences, Zabol, Iran.
authors.forename: Mahdi
authors.initials: M
authors.lastname: Afshari
authors.affiliation: Gastroenterology and Liver Diseases Research Center, Baqiyatallah University of Medical Science, Tehran, Iran.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Khodadost
authors.affiliation: Health Policy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: M.akbari45@yahoo.com.
authors.forename: Maryam
authors.initials: M
authors.lastname: Akbari
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D016640:Diabetes, Gestational / Q000209:etiology*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007492:Iran; D011247:Pregnancy; D011379:Prognosis; D012307:Risk Factors
keywords: Diabetes; Family history of diabetes; Gestational diabetes mellitus; Meta-analysis