title: Breath Alkane as an index of severity for oral submucous fibrosis: A new perspective?
abstract: Oral submucous fibrosis (OSMF) is a devastating disease commonly seen in the Asian subcontinent that results in significant functional morbidity for patients and has a high potential for malignant transformation. Over the last three decades, different diagnostic methods have been described to quantify and grade OSMF severity. Some methods have been used with perceived favorable outcomes although recurrence and malignant transformation remains a problem in many cases, and OSMF presents a major therapeutic challenge. We present a simple, noninvasive and less time-consuming diagnostic method which measures the severity of OSMF, helping to predict its malignant transformation and monitoring the effect of medical therapy on this disease.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Navodaya Dental College and Hospital, Raichur, Karnataka, India. Electronic address: gururaj.arakeri@gmail.com.
authors.forename: Gururaj
authors.initials: G
authors.lastname: Arakeri
authors.affiliation: Department of Oral and Maxillofacial Surgery and Oral Disease of Arnaldo Viera de Carvalho Cancer Institute, SP, Brazil.
authors.forename: George
authors.initials: G
authors.lastname: Boraks
authors.affiliation: Department of Medical Oncology, HCG Cancer Hospital, Bangalore, India.
authors.forename: Abdulsalam S
authors.initials: AS
authors.lastname: Aljabab
authors.affiliation: King Fahad Medical City, Department of Dentistry, Faculty of Dentistry, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Shekar Gowda
authors.initials: SG
authors.lastname: Patil
authors.affiliation: Department of Oral and Maxillofacial Surgery, Radboud University Medical Centre, Nijmegen, The Netherlands.
authors.forename: M A W
authors.initials: MA
authors.lastname: Merkx
authors.affiliation: Department of Oral & Maxillofacial Surgery, Queen Alexandra Hospital, Cosham, Portsmouth PO6 3LY, United Kingdom.
authors.forename: Peter A
authors.initials: PA
authors.lastname: Brennan
mesh_terms: D000473:Alkanes / Q000737:chemistry*; D000818:Animals; D000975:Antioxidants / Q000737:chemistry; D015415:Biomarkers / Q000378:metabolism; D001944:Breath Tests / Q000379:methods*; D006801:Humans; D015227:Lipid Peroxidation; D009055:Mouth / Q000473:pathology; D009914:Oral Submucous Fibrosis / Q000175:diagnosis* / Q000378:metabolism; D018384:Oxidative Stress; D015203:Reproducibility of Results; D012720:Severity of Illness Index
chemical_list: D000473:Alkanes; D000975:Antioxidants; D015415:Biomarkers
keywords: Breath Alkane; Diagnosis; Oral submucous fibrosis; Oxidative stress