title: Resveratrol as an anti-cancer agent: A review.
abstract: Owing to their antimicrobial, antioxidant, and anti-inflammatory activity, grapes (Vitis vinifera L.) are the archetypal paradigms of fruits used not only for nutritional purposes, but also for exclusive therapeutics. Grapes are a prominent and promising source of phytochemicals, especially resveratrol, a phytoalexin antioxidant found in red grapes which has both chemopreventive and therapeutic effects against various ailments. Resveratrol's role in reducing different human cancers, including breast, cervical, uterine, blood, kidney, liver, eye, bladder, thyroid, esophageal, prostate, brain, lung, skin, gastric, colon, head and neck, bone, ovarian, and cervical, has been reviewed. This review covers the literature that deals with the anti-cancer mechanism of resveratrol with special reference to antioxidant potential. Furthermore, this article summarizes the literature pertaining to resveratrol as an anti-cancer agent.
authors.affiliation: a Department of Chemistry , University of Swabi , Khyber Pakhtunkhwa , Pakistan.
authors.forename: Abdur
authors.initials: A
authors.lastname: Rauf
authors.affiliation: b Department of Diet and Nutritional Sciences , Imperial College of Business Studies , Lahore , Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Imran
authors.affiliation: c Faculty of Food, Nutrition and Home Sciences, Agriculture University of Faisalabad , Faisalabad , Pakistan.
authors.forename: Masood Sadiq
authors.initials: MS
authors.lastname: Butt
authors.affiliation: d Department of Environmental Sciences , COMSATS Institute of Information Technology , Vehari , Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Nadeem
authors.affiliation: e Department of Chemistry , Indiana University , Bloomington , Indiana , USA.
authors.forename: Dennis G
authors.initials: DG
authors.lastname: Peters
authors.affiliation: f Department of Chemistry , The University of Jordan , Amman , Jordan.
authors.forename: Mohammad S
authors.initials: MS
authors.lastname: Mubarak
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D045744:Cell Line, Tumor; D004195:Disease Models, Animal; D005638:Fruit; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000517:prevention & control*; D064209:Phytochemicals / Q000494:pharmacology; D000077185:Resveratrol; D012717:Sesquiterpenes / Q000494:pharmacology; D013267:Stilbenes / Q000494:pharmacology*; D027843:Vitis / Q000737:chemistry; D000094162:Phytoalexins
chemical_list: D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D064209:Phytochemicals; D012717:Sesquiterpenes; D013267:Stilbenes; D000077185:Resveratrol; D000094162:Phytoalexins
keywords: Resveratrol; chemopreventive agent; human cancers