title: Dynamic chromatin regulation at Notch target genes.
abstract: RBPJ is the central transcription factor that controls the Notch-dependent transcriptional response by coordinating repressing histone H3K27 deacetylation and activating histone H3K4 methylation. Here, we discuss the molecular mechanisms how RBPJ interacts with opposing NCoR/HDAC-corepressing or KMT2D/UTX-coactivating complexes and how this is controlled by phosphorylation of chromatin modifiers.
authors.affiliation: a Institute of Biochemistry, Justus Liebig University , Giessen , Germany.
authors.forename: Benedetto Daniele
authors.initials: BD
authors.lastname: Giaimo
authors.affiliation: b Department of Internal Medicine I , Center for Internal Medicine, University Medical Center Ulm , Ulm , Germany.
authors.forename: Franz
authors.initials: F
authors.lastname: Oswald
authors.affiliation: a Institute of Biochemistry, Justus Liebig University , Giessen , Germany.
authors.forename: Tilman
authors.initials: T
authors.lastname: Borggrefe
mesh_terms: D000107:Acetylation; D000818:Animals; D002843:Chromatin / Q000378:metabolism*; D005786:Gene Expression Regulation; D053263:Gene Regulatory Networks; D006657:Histones / Q000737:chemistry; D006801:Humans; D051819:Immunoglobulin J Recombination Signal Sequence-Binding Protein / Q000378:metabolism*; D008745:Methylation; D046912:Multiprotein Complexes / Q000378:metabolism; D010766:Phosphorylation; D011485:Protein Binding; D051880:Receptors, Notch / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D002843:Chromatin; D006657:Histones; D051819:Immunoglobulin J Recombination Signal Sequence-Binding Protein; D046912:Multiprotein Complexes; D051880:Receptors, Notch
keywords: KMT2D; NCoR; NICD; Notch; RBPJ; SHARP; casein kinase 2; chromatin; transcription; transcriptional activation; transcriptional repression