title: The Emerging Role of MicroRNA-155 in Cardiovascular Diseases.
abstract: MicroRNAs have been demonstrated to be involved in human diseases, including cardiovascular diseases. Growing evidences suggest that microRNA-155, a typical multifunctional microRNA, plays a crucial role in hematopoietic lineage differentiation, immunity, inflammation, viral infections, and vascular remodeling, which is linked to cardiovascular diseases such as coronary artery disease, abdominal aortic aneurysm, heart failure, and diabetic heart disease. The effects of microRNA-155 in different cell types through different target genes result in different mechanisms in diseases. MicroRNA-155 has been intensively studied in atherosclerosis and coronary artery disease. Contradictory results of microRNA-155 either promoting or preventing the pathophysiological process of atherosclerosis illustrate the complexity of this pleiotropic molecule. Therefore, more comprehensive studies of the underlying mechanisms of microRNA-155 involvement in cardiovascular diseases are required. Furthermore, a recent clinical trial of Miravirsen targeting microRNA-122 sheds light on exploiting microRNA-155 as a novel target to develop effective therapeutic strategies for cardiovascular diseases in the near future.
authors.affiliation: Laboratory of Immunology, Shanghai Xuhui Central Hospital/Shanghai Zhongshan-Xuhui Hospital, Fudan University/Shanghai Clinical Research Center, Chinese Academy of Sciences, 966 Middle Huaihai Road, Shanghai 200031, China.
authors.forename: Richard Y
authors.identifier: 0000-0002-8743-9125
authors.initials: RY
authors.lastname: Cao
authors.affiliation: Department of Rehabilitation, Shanghai Xuhui Central Hospital/Shanghai Zhongshan-Xuhui Hospital, Fudan University/Shanghai Clinical Research Center, Chinese Academy of Sciences, 966 Middle Huaihai Road, Shanghai 200031, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Li
authors.affiliation: Clinical Laboratory, Shanghai Xuhui Central Hospital/Shanghai Zhongshan-Xuhui Hospital, Fudan University/Shanghai Clinical Research Center, Chinese Academy of Sciences, 966 Middle Huaihai Road, Shanghai 200031, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Miao
authors.affiliation: Department of Rehabilitation, Shanghai Xuhui Central Hospital/Shanghai Zhongshan-Xuhui Hospital, Fudan University/Shanghai Clinical Research Center, Chinese Academy of Sciences, 966 Middle Huaihai Road, Shanghai 200031, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Rehabilitation, Shanghai Xuhui Central Hospital/Shanghai Zhongshan-Xuhui Hospital, Fudan University/Shanghai Clinical Research Center, Chinese Academy of Sciences, 966 Middle Huaihai Road, Shanghai 200031, China.
authors.forename: Wenchao
authors.initials: W
authors.lastname: Yuan
authors.affiliation: Department of Rehabilitation, Shanghai Xuhui Central Hospital/Shanghai Zhongshan-Xuhui Hospital, Fudan University/Shanghai Clinical Research Center, Chinese Academy of Sciences, 966 Middle Huaihai Road, Shanghai 200031, China.
authors.forename: Li
authors.initials: L
authors.lastname: Fan
authors.affiliation: Department of Rehabilitation, Shanghai Xuhui Central Hospital/Shanghai Zhongshan-Xuhui Hospital, Fudan University/Shanghai Clinical Research Center, Chinese Academy of Sciences, 966 Middle Huaihai Road, Shanghai 200031, China.
authors.forename: Gongliang
authors.initials: G
authors.lastname: Liu
authors.affiliation: School of Life Sciences, Shanghai University, 99 Shangda Road, Shanghai 200444, China.
authors.forename: Qiongyao
authors.initials: Q
authors.lastname: Mi
authors.affiliation: Department of Rehabilitation, Shanghai Xuhui Central Hospital/Shanghai Zhongshan-Xuhui Hospital, Fudan University/Shanghai Clinical Research Center, Chinese Academy of Sciences, 966 Middle Huaihai Road, Shanghai 200031, China.
authors.forename: Jian
authors.identifier: 0000-0003-2679-9095
authors.initials: J
authors.lastname: Yang
mesh_terms: D002318:Cardiovascular Diseases / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000627:therapeutic use; D058990:Molecular Targeted Therapy
chemical_list: C524942:MIRN155 microRNA, human; D035683:MicroRNAs