title: Lead-Free Piezoelectric (Ba,Ca)(Zr,Ti)O3Thin Films for Biocompatible and Flexible Devices.
abstract: In this work, we report the synthesis of functional biocompatible piezoelectric (1 - x)Ba(Ti0.8Zr0.2)TiO3-x(Ba0.7Ca0.3)TiO3, x = 0.45 (BCZT45), thin films with high piezoelectric properties. Pulsed-laser-based techniques, classical pulsed-laser deposition and matrix-assisted pulsed-laser evaporation, were used to synthesize the BCZT45 thin films. The second technique was employed in order to ensure growth on polymer flexible Kapton substrates. The BCZT45 thin films grown by both techniques show similar structural properties and high piezoelectric coefficient coupling between the mechanical loading and electrical potential. While it has long been shown that the electrical potential favors biological processes like osteogenesis, the assessment of cell adhesion and osteogenic differentiation onto BCZT materials has not yet been demonstrated. We prove here for the first time that BCZT 45 coatings on Kapton polymer substrates provide optimal support for osteogenic differentiation of mesenchymal stem cells in the bone marrow.
authors.affiliation: National Institute for Laser, Plasma and Radiation Physics , 077125 Magurele, Romania.
authors.forename: N D
authors.initials: ND
authors.lastname: Scarisoreanu
authors.affiliation: CNR-ISC, Istituto dei Sistemi Complessi , Area della Ricerca di Roma-Tor Vergata, Via del Fosso del Cavaliere 100, I-00133 Rome, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Craciun
authors.affiliation: National Institute for Laser, Plasma and Radiation Physics , 077125 Magurele, Romania.
authors.forename: V
authors.initials: V
authors.lastname: Ion
authors.affiliation: National Institute for Laser, Plasma and Radiation Physics , 077125 Magurele, Romania.
authors.forename: R
authors.initials: R
authors.lastname: Birjega
authors.affiliation: National Institute for Laser, Plasma and Radiation Physics , 077125 Magurele, Romania.
authors.forename: A
authors.initials: A
authors.lastname: Bercea
authors.affiliation: National Institute for Laser, Plasma and Radiation Physics , 077125 Magurele, Romania.
authors.forename: V
authors.initials: V
authors.lastname: Dinca
authors.affiliation: National Institute for Laser, Plasma and Radiation Physics , 077125 Magurele, Romania.
authors.forename: M
authors.identifier: 0000-0001-7327-8714
authors.initials: M
authors.lastname: Dinescu
authors.affiliation: Institute of Biochemistry of the Romanian Academy , 296 Splaiul Independentei, 060031 Bucharest, Romania.
authors.forename: L E
authors.initials: LE
authors.lastname: Sima
authors.affiliation: Institute of Biochemistry of the Romanian Academy , 296 Splaiul Independentei, 060031 Bucharest, Romania.
authors.forename: M
authors.initials: M
authors.lastname: Icriverzi
authors.affiliation: Institute of Biochemistry of the Romanian Academy , 296 Splaiul Independentei, 060031 Bucharest, Romania.
authors.forename: A
authors.initials: A
authors.lastname: Roseanu
authors.affiliation: Medinsys Craiova , Calea Unirii 32, 200409 Craiova, Romania.|Faculty of Mechanics, University of Craiova , Alexandru Ioan Cuza 13, 200585 Craiova, Romania.
authors.forename: L
authors.initials: L
authors.lastname: Gruionu
authors.affiliation: Medinsys Craiova , Calea Unirii 32, 200409 Craiova, Romania.|Department of Surgery, Harvard Medical School and Massachusetts General Hospital , 55 Fruit Street White 506, Boston, Massachusetts 02114, United States.
authors.forename: G
authors.initials: G
authors.lastname: Gruionu
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D002448:Cell Adhesion; D007834:Lasers; D010012:Osteogenesis; D011108:Polymers
chemical_list: D001672:Biocompatible Materials; D011108:Polymers
keywords: biocompatible materials; laser processing; lead-free thin films; mesenchymal stem cells; osteogenic differentiation