title: Age of Transfused Blood Impacts Perioperative Outcomes Among Patients Who Undergo Major Gastrointestinal Surgery.
abstract: To evaluate the impact of transfused packed red blood cell (PRBC) age on perioperative morbidity among patients undergoing major gastrointestinal surgery.
  
  
  
  Patients undergoing major surgery often receive PRBC transfusions. The effect of PRBC age (ie, storage duration before transfusion) on perioperative surgical outcomes remains poorly defined.
  
  
  
  In this study, 1365 patients were identified who underwent a hepato-pancreatic or colorectal resection and received ≥1 unit of PRBCs between 2009 and 2014 at the Johns Hopkins Hospital. Data regarding the storage duration of PRBCs, clinicopathologic characteristics, and perioperative outcomes were obtained and analyzed. Multivariable modified Poisson regression analyses were performed to assess the effect of PRBC age on perioperative morbidity.
  
  
  
  A total of 5901 PRBC units were transfused for a median of 2 (interquartile range 2-4) units transfused per patient. In all, 936 (68.6%) patients received only units of blood that had been stored for less than 35 days ("fresh" blood), whereas 429 (31.4%) patients received at least 1 unit of PRBC that had been stored for ≥35 days ("older" blood). Overall postoperative morbidity was 32.8%. The incidence of postoperative complications (42.7% vs 28.3%) was higher among patients who received "older" vs "fresh" blood (P < 0.001). After adjusting for confounders on multivariable analysis, transfusion of "older" blood remained independently associated with an increased risk of perioperative morbidity (Relative Risk 1.20, P = 0.03).
  
  
  
  The use of "older" blood was an independent predictor of postoperative morbidity among patients undergoing hepato-pancreatic or colorectal procedures. Transfusion of "older" blood products may contribute to a higher risk of postoperative complications.
authors.affiliation: *Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD †The Johns Hopkins University School of Medicine, Baltimore, MD ‡Department of Surgery, University of Illinois Hospital and Health Sciences System, Chicago, IL §Department of Anesthesiology, The Johns Hopkins University School of Medicine, Baltimore, MD ¶Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, MD.
authors.forename: Yuhree
authors.initials: Y
authors.lastname: Kim
authors.forename: Neda
authors.initials: N
authors.lastname: Amini
authors.forename: Faiz
authors.initials: F
authors.lastname: Gani
authors.forename: Doris
authors.initials: D
authors.lastname: Wagner
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Johnson
authors.forename: Andrew
authors.initials: A
authors.lastname: Scott
authors.forename: Aslam
authors.initials: A
authors.lastname: Ejaz
authors.forename: Georgios A
authors.initials: GA
authors.lastname: Margonis
authors.forename: Li
authors.initials: L
authors.lastname: Xu
authors.forename: Stefan
authors.initials: S
authors.lastname: Buettner
authors.forename: Jack O
authors.initials: JO
authors.lastname: Wasey
authors.forename: Ruchika
authors.initials: R
authors.lastname: Goel
authors.forename: Steven M
authors.initials: SM
authors.lastname: Frank
authors.forename: Timothy M
authors.initials: TM
authors.lastname: Pawlik
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001793:Blood Preservation / Q000009:adverse effects* / Q000379:methods; D016208:Databases, Factual; D013505:Digestive System Surgical Procedures; D017707:Erythrocyte Transfusion; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D017063:Outcome Assessment, Health Care; D019990:Perioperative Care; D016012:Poisson Distribution; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology*; D012307:Risk Factors; D055815:Young Adult