title: Effects of glutathione S-transferase M1 andT1 deletions on bipolar disorder risk among a Tunisian population.
abstract: Glutathione S-transferases (GSTs) enzymes are involved in the detoxification of several endogenous and exogenous substances. In this study, we evaluated the effects of two glutathione S-transferase polymorphisms, (GSTM1 and GSTT1) on bipolar disorder (BPD) risk susceptibility in a Tunisian population. These polymorphisms were analyzed in 229 healthy subjects and 109 patients with BPD, using a polymerase chain reaction. Statistical analysis was performed using SPSS 18.0. The relative associations between the GSTs genotypes and BPD were assessed by calculating odds ratios (ORs) and 95% confidence intervals (CLs). The study results demonstrated that individuals with GSTM1 [OR=1.51, 95% CI: 0.93-2.45, p=0.081] or GSTT1 [OR=1.65, 95% CI: 0.95-2.88, p=0.060] were not associated with the risk of BPD, whereas a significant association was found between individuals with both GSTM1/T1 null genotype and BPD risk [OR=2.96, 95% CI (1.26-7.03), p=0.005]. These genotyping finding revealed that the absence of both GSTM1 and GSTT1 activity could be a contributor factor for the development of BPD.
authors.affiliation: Metabolic Biophysics, Professional Toxicology and Applied Environmental Laboratory, Department of Biophysics, Medicine Faculty of Sousse, Sousse University, Sousse 4002, Tunisia. Electronic address: chahra.chbili@yahoo.com.
authors.forename: Chahra
authors.initials: C
authors.lastname: Chbili
authors.affiliation: Laboratory of Genetics, Biodiversity and Valorization of Bio-resources, Higher Institute of Biotechnology of Monastir, University of Monastir, Monastir, Tunisia.
authors.forename: Ahlem
authors.initials: A
authors.lastname: Elouaer
authors.affiliation: Metabolic Biophysics, Professional Toxicology and Applied Environmental Laboratory, Department of Biophysics, Medicine Faculty of Sousse, Sousse University, Sousse 4002, Tunisia.
authors.forename: Neila
authors.initials: N
authors.lastname: Fathallah
authors.affiliation: Metabolic Biophysics, Professional Toxicology and Applied Environmental Laboratory, Department of Biophysics, Medicine Faculty of Sousse, Sousse University, Sousse 4002, Tunisia.
authors.forename: Manel
authors.initials: M
authors.lastname: Nouira
authors.affiliation: Laboratory of Genetics, Biodiversity and Valorization of Bio-resources, Higher Institute of Biotechnology of Monastir, University of Monastir, Monastir, Tunisia.
authors.forename: Besma Bel Hadj
authors.initials: BB
authors.lastname: Jrad
authors.affiliation: Laboratory of Psychiatry and Vulnerability to Psychosis-CHU Fattouma Bourguiba Monastir, University of Monastir, Monastir, Tunisia.
authors.forename: Lotfi
authors.initials: L
authors.lastname: Gaha
authors.affiliation: Metabolic Biophysics, Professional Toxicology and Applied Environmental Laboratory, Department of Biophysics, Medicine Faculty of Sousse, Sousse University, Sousse 4002, Tunisia. Electronic address: khaled_saguem@yahoo.fr.
authors.forename: Saad
authors.initials: S
authors.lastname: Saguem
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D014416:Tunisia; D055815:Young Adult
chemical_list: D005982:Glutathione Transferase; C413545:glutathione S-transferase T1
keywords: Bipolar disorder; Genetic polymorphisms; Glutathione S-transferase M1; Glutathione S-transferase T1