title: Renoprotection: focus on TRPV1, TRPV4, TRPC6 and TRPM2.
abstract: Members of the transient receptor potential (TRP) cation channel receptor family have unique sites of regulatory function in the kidney which enables them to promote regional vasodilatation and controlled Ca2+influx into podocytes and tubular cells. Activated TRP vanilloid 1 receptor channels (TRPV1) have been found to elicit renoprotection in rodent models of acute kidney injury following ischaemia/reperfusion. Transient receptor potential cation channel, subfamily C, member 6 (TRPC6) in podocytes is involved in chronic proteinuric kidney disease, particularly in focal segmental glomerulosclerosis (FSGS). TRP vanilloid 4 receptor channels (TRPV4) are highly expressed in the kidney, where they induce Ca2+influx into endothelial and tubular cells. TRP melastatin (TRPM2) non-selective cation channels are expressed in the cytoplasm and intracellular organelles, where their inhibition ameliorates ischaemic renal pathology. Although some of their basic properties have been recently identified, the renovascular role of TRPV1, TRPV4, TRPC6 and TRPM2 channels in disease states such as obesity, hypertension and diabetes is largely unknown. In this review, we discuss recent evidence for TRPV1, TRPV4, TRPC6 and TRPM2 serving as potential targets for acute and chronic renoprotection in chronic vascular and metabolic disease.
authors.affiliation: Experimental and Clinical Research Center, A Joint Cooperation Between the Charité Medical Faculty and the Max-Delbrück Center (MDC) for Molecular Medicine, Berlin, Germany.
authors.forename: L
authors.initials: L
authors.lastname: Markó
authors.affiliation: Experimental and Clinical Research Center, A Joint Cooperation Between the Charité Medical Faculty and the Max-Delbrück Center (MDC) for Molecular Medicine, Berlin, Germany.|Charité Campus Virchow, Nephrology/Intensive Care, Berlin, Germany.|German Institute of Human Nutrition, Potsdam-Rehbrücke, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Mannaa
authors.affiliation: Experimental and Clinical Research Center, A Joint Cooperation Between the Charité Medical Faculty and the Max-Delbrück Center (MDC) for Molecular Medicine, Berlin, Germany.|German Institute of Human Nutrition, Potsdam-Rehbrücke, Germany.
authors.forename: T N
authors.initials: TN
authors.lastname: Haschler
authors.affiliation: German Institute of Human Nutrition, Potsdam-Rehbrücke, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Krämer
authors.affiliation: Experimental and Clinical Research Center, A Joint Cooperation Between the Charité Medical Faculty and the Max-Delbrück Center (MDC) for Molecular Medicine, Berlin, Germany.|Charité Campus Virchow, Nephrology/Intensive Care, Berlin, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Gollasch
mesh_terms: D058186:Acute Kidney Injury / Q000378:metabolism*; D000818:Animals; D006801:Humans; D050052:TRPC Cation Channels / Q000378:metabolism*; D050053:TRPM Cation Channels / Q000378:metabolism*; D050916:TRPV Cation Channels / Q000378:metabolism*
chemical_list: D050052:TRPC Cation Channels; D050053:TRPM Cation Channels; D050916:TRPV Cation Channels
keywords: TRPC6; TRPM2; TRPV1; TRPV4; capsaicin; hyperforin