title: PBIT: Pipeline Builder for Identification of drug Targets for infectious diseases.
abstract: PBIT (Pipeline Builder for Identification of drug Targets) is an online webserver that has been developed for screening of microbial proteomes for critical features of human drug targets such as being non-homologous to human proteome as well as the human gut microbiota, essential for the pathogen's survival, participation in pathogen-specific pathways etc. The tool has been validated by analyzing 57 putative targets of Candida albicans documented in literature. PBIT integrates various in silico approaches known for drug target identification and will facilitate high-throughput prediction of drug targets for infectious diseases, including multi-pathogenic infections.
  
  
  
  PBIT is freely accessible at http://www.pbit.bicnirrh.res.in/ .
  
  
  
  thomass@nirrh.res.in.
  
  
  
  Supplementary data are available at Bioinformatics online.
authors.affiliation: ICMR Biomedical Informatics Center, National Institute for Research in Reproductive Health, Mumbai, India.
authors.forename: Gauri
authors.initials: G
authors.lastname: Shende
authors.affiliation: ICMR Biomedical Informatics Center, National Institute for Research in Reproductive Health, Mumbai, India.
authors.forename: Harshala
authors.initials: H
authors.lastname: Haldankar
authors.affiliation: ICMR Biomedical Informatics Center, National Institute for Research in Reproductive Health, Mumbai, India.
authors.forename: Ram Shankar
authors.initials: RS
authors.lastname: Barai
authors.affiliation: ICMR Biomedical Informatics Center, National Institute for Research in Reproductive Health, Mumbai, India.
authors.forename: Mohammed Husain
authors.initials: MH
authors.lastname: Bharmal
authors.affiliation: ICMR Biomedical Informatics Center, National Institute for Research in Reproductive Health, Mumbai, India.
authors.forename: Vinit
authors.initials: V
authors.lastname: Shetty
authors.affiliation: ICMR Biomedical Informatics Center, National Institute for Research in Reproductive Health, Mumbai, India.
authors.forename: Susan
authors.initials: S
authors.lastname: Idicula-Thomas
mesh_terms: D002176:Candida albicans / Q000187:drug effects / Q000378:metabolism; D003141:Communicable Diseases / Q000188:drug therapy* / Q000382:microbiology; D019295:Computational Biology / Q000379:methods; D003198:Computer Simulation; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D020407:Internet; D064307:Microbiota / Q000187:drug effects*; D020543:Proteome / Q000187:drug effects*
chemical_list: D020543:Proteome