title: Impaired fasting blood glucose is associated to cognitive impairment and cerebral atrophy in middle-aged non-human primates.
abstract: Age-associated cognitive impairment is a major health and social issue because of increasing aged population. Cognitive decline is not homogeneous in humans and the determinants leading to differences between subjects are not fully understood. In middle-aged healthy humans, fasting blood glucose levels in the upper normal range are associated with memory impairment and cerebral atrophy. Due to a close evolutional similarity to Man, non-human primates may be useful to investigate the relationships between glucose homeostasis, cognitive deficits and structural brain alterations. In the grey mouse lemur,Microcebus murinus, spatial memory deficits have been associated with age and cerebral atrophy but the origin of these alterations have not been clearly identified. Herein, we showed that, on 28 female grey mouse lemurs (age range 2.4-6.1 years-old), age correlated with impaired fasting blood glucose (rs=0.37) but not with impaired glucose tolerance or insulin resistance. In middle-aged animals (4.1-6.1 years-old), fasting blood glucose was inversely and closely linked with spatial memory performance (rs=0.56) and hippocampus (rs=-0.62) or septum (rs=-0.55) volumes. These findings corroborate observations in humans and further support the grey mouse lemur as a natural model to unravel mechanisms which link impaired glucose homeostasis, brain atrophy and cognitive processes.
authors.affiliation: MECADEV UMR 7179, Centre National de la Recherche Scientifique, Muséum National d'Histoire Naturelle, 91800 Brunoy, France.|Université Sorbonne Paris Cité, 75013 Paris, France.
authors.forename: Fathia
authors.initials: F
authors.lastname: Djelti
authors.affiliation: Centre National de la Recherche Scientifique, Université Paris Sud, Université Paris Saclay, UMR 9199, Neurodegenerative Diseases Laboratory, 92265 Fontenay-aux-Roses, France.|Commissariat à l'Energie Atomique et aux Energies Alternatives (CEA), Direction de la Recherche Fondamentale (DRF), Institut d'Imagerie Biomédicale (I2BM), MIRCen, 92265 Fontenay-aux-Roses, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Dhenain
authors.affiliation: MECADEV UMR 7179, Centre National de la Recherche Scientifique, Muséum National d'Histoire Naturelle, 91800 Brunoy, France.
authors.forename: Jérémy
authors.initials: J
authors.lastname: Terrien
authors.affiliation: Laboratoire de Psychopathologie et de Neuropsychologie, EA 2027, Université Paris 8, 93200 Saint-Denis, France.
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Picq
authors.affiliation: MECADEV UMR 7179, Centre National de la Recherche Scientifique, Muséum National d'Histoire Naturelle, 91800 Brunoy, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Hardy
authors.affiliation: MECADEV UMR 7179, Centre National de la Recherche Scientifique, Muséum National d'Histoire Naturelle, 91800 Brunoy, France.
authors.forename: Delphine
authors.initials: D
authors.lastname: Champeval
authors.affiliation: MECADEV UMR 7179, Centre National de la Recherche Scientifique, Muséum National d'Histoire Naturelle, 91800 Brunoy, France.
authors.forename: Martine
authors.initials: M
authors.lastname: Perret
authors.affiliation: Institut de Recherches Servier, 78290 Croissy-sur-Seine, France.
authors.forename: Esther
authors.initials: E
authors.lastname: Schenker
authors.affiliation: MECADEV UMR 7179, Centre National de la Recherche Scientifique, Muséum National d'Histoire Naturelle, 91800 Brunoy, France.|Université Sorbonne Paris Cité, 75013 Paris, France.|Centre Psychiatrie & Neurosciences, UMR S894 INSERM, Université Paris Descartes, 75014 Paris, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Epelbaum
authors.affiliation: MECADEV UMR 7179, Centre National de la Recherche Scientifique, Muséum National d'Histoire Naturelle, 91800 Brunoy, France.
authors.forename: Fabienne
authors.initials: F
authors.lastname: Aujard
mesh_terms: D000367:Age Factors; D000818:Animals; D001284:Atrophy / Q000097:blood / Q000000981:diagnostic imaging / Q000473:pathology*; D001786:Blood Glucose / Q000032:analysis*; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000473:pathology*; D016565:Cheirogaleidae; D060825:Cognitive Dysfunction / Q000097:blood* / Q000000981:diagnostic imaging / Q000473:pathology; D005215:Fasting / Q000097:blood*; D005260:Female; D009929:Organ Size / Q000502:physiology; D065852:Spatial Memory / Q000502:physiology*
chemical_list: D001786:Blood Glucose
keywords: Microcebus murinus; blood glucose; hippocampal/septal atrophy; middle age; spatial memory performance; spontaneous models