title: Top-down modulation of olfactory-guided behaviours by the anterior olfactory nucleus pars medialis and ventral hippocampus.
abstract: Olfactory processing is thought to be actively modulated by the top-down input from cortical regions, but the behavioural function of these signals remains unclear. Here we find that cortical feedback from the anterior olfactory nucleus pars medialis (mAON) bidirectionally modulates olfactory sensitivity and olfaction-dependent behaviours. To identify a limbic input that tunes this mAON switch, we further demonstrate that optogenetic stimulation of ventral hippocampal inputs to the mAON is sufficient to alter olfaction-dependent behaviours.
authors.affiliation: Department of Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, Ontario, Canada M5S 3G5.
authors.forename: Afif J
authors.initials: AJ
authors.lastname: Aqrabawi
authors.affiliation: Department of Psychology, University of Toronto, 100 St. George Street, Toronto, Ontario, Canada M5S 3G3.
authors.forename: Caleb J
authors.initials: CJ
authors.lastname: Browne
authors.affiliation: Department of Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, Ontario, Canada M5S 3G5.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Dargaei
authors.affiliation: Department of Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, Ontario, Canada M5S 3G5.
authors.forename: Danielle
authors.initials: D
authors.lastname: Garand
authors.affiliation: Department of Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, Ontario, Canada M5S 3G5.
authors.forename: C Sahara
authors.initials: CS
authors.lastname: Khademullah
authors.affiliation: Department of Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, Ontario, Canada M5S 3G5.
authors.forename: Melanie A
authors.identifier: 0000-0003-2984-8630
authors.initials: MA
authors.lastname: Woodin
authors.affiliation: Department of Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, Ontario, Canada M5S 3G5.|Department of Psychology, University of Toronto, 100 St. George Street, Toronto, Ontario, Canada M5S 3G3.
authors.forename: Jun Chul
authors.initials: JC
authors.lastname: Kim
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D003485:Cyanates / Q000494:pharmacology; D049452:Green Fluorescent Proteins / Q000235:genetics / Q000378:metabolism; D006624:Hippocampus / Q000502:physiology*; D008164:Luminescent Proteins / Q000235:genetics / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D066194:Olfactory Cortex / Q000502:physiology*; D009833:Olfactory Pathways / Q000187:drug effects / Q000502:physiology; D062308:Optogenetics; D012903:Smell / Q000502:physiology*; D000097573:Red Fluorescent Protein
chemical_list: D001426:Bacterial Proteins; D003485:Cyanates; D049452:Green Fluorescent Proteins; D008164:Luminescent Proteins; D000097573:Red Fluorescent Protein; C054562:yellow fluorescent protein, Bacteria