title: Association of C1q/TNF-Related Protein-3 (CTRP3) and CTRP13 Serum Levels with Coronary Artery Disease in Subjects with and without Type 2 Diabetes Mellitus.
abstract: C1q/TNF-Related Protein-3 (CTRP3) and CTRP13 are two newly discovered adipokines regulating glucose and lipid metabolism. But their role in type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD) is still in infancy. The aim of this study was to investigate the associations of gene expression and serum levels of CTRP3 and CTRP13 with CAD, metabolic and inflammatory markers in patients with and without T2DM. Serum levels of CTRP3, CTRP13, adiponectin and inflammatory cytokines and their gene expression in peripheral blood mononuclear cells (PBMCs) were determined in 172 subjects categorized as group I (without T2DM and CAD), group II (with CAD but no T2DM), group III (with T2DM but no CAD) and group IV (with T2DM and CAD). Serum levels and gene expression of CTRP3, CTRP13 and adiponectin in the group I were higher compared to other groups. Inflammatory cytokines in the control group were lower than other groups too. CTRP3 serum levels have an independent association with BMI, smoking and CTRP3 gene expression; also CTRP13 serum levels has an independent association with BMI, HDL-C, insulin, HOMA-IR, HbA1c and TNF-α. Decreased serum levels of CTRP3 and CTRP13 were also associated with CAD. It appears that the decreased levels of CTRP3 and especially CTRP13 were associated with increased risk of T2DM and CAD. These findings suggest an emerging role of these adipokines in the pathogenesis of CAD, but further studies are necessary to establish this concept.
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.|Department of Clinical Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Fadaei
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Nariman
authors.initials: N
authors.lastname: Moradi
authors.affiliation: Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Baratchian
authors.affiliation: Interventional Cardiology Department, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Hassan
authors.initials: H
authors.lastname: Aghajani
authors.affiliation: Research Center for Prevention of Cardiovascular Disease, Institute of Endocrinology & Metabolism, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Mojtaba
authors.initials: M
authors.lastname: Malek
authors.affiliation: Department of Clinical Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Ali Akbar
authors.initials: AA
authors.lastname: Fazaeli
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.|Research Center of Pediatric Infectious Disease, Rasool Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Soudabeh
authors.initials: S
authors.lastname: Fallah
mesh_terms: D054392:Adipokines / Q000097:blood / Q000378:metabolism; D000368:Aged; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D015922:Complement C1q / Q000235:genetics / Q000378:metabolism*; D003324:Coronary Artery Disease / Q000097:blood* / Q000150:complications* / Q000235:genetics; D016207:Cytokines / Q000097:blood / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D048069:Tumor Necrosis Factors / Q000097:blood* / Q000235:genetics
chemical_list: D054392:Adipokines; D015415:Biomarkers; C000621176:C1QL3 protein, human; C506069:C1QTNF3 protein, human; D016207:Cytokines; D048069:Tumor Necrosis Factors; D015922:Complement C1q