title: Characterizations and bioactivities of abendazole sulfoxide-loaded thermo-sensitive hydrogel.
abstract: Albendazole (ABZ), a widely used anthelmintic, attributes its primary metabolite-albendazole sulfoxide (ABZSO)-as an effective agent against helminthes. For a purpose of long-lasting releasing ABZSO in a special lesion, the present study successfully manufactured ABZSO-loaded thermo-sensitive hydrogel, which was proved by FTIR and1H NMR, in the interim; in vitro and in vivo behaviors of the thermo-sensitive hydrogel containing ABZSO were studied too. The in vivo pharmacokinetics parameters indicated ABZSO-loaded hydrogel as a better choice for sustained release compared with simple ABZSO. Additionally, the effect of the prepared hydrogels against helminth was investigated by the lethality of Caenorhabditis elegans, the results indicated that the lethality of ABZSO-loaded hydrogel (1, 2, and 4 mg/ml, respectively) on C. elegans was higher than that of PLGA-PEG-PLGA group (P < 0.05). It suggested that the hydrogels loaded with albendazole sulfoxide could be considered highly effective against the nematode C. elegans.
authors.affiliation: Department of Pathogenic Biology, Chongqing Medical University, Chongqing, 400016, People's Republic of China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Feng
authors.affiliation: Department of Pathogenic Biology, Chongqing Medical University, Chongqing, 400016, People's Republic of China.
authors.forename: Fen
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Pathogenic Biology, Chongqing Medical University, Chongqing, 400016, People's Republic of China.
authors.forename: Xue-Wei
authors.initials: XW
authors.lastname: Zhang
authors.affiliation: Batch 2013, Clinical Medicine, College of Overseas Student, Chongqing Medical University, Chongqing, 400016, People's Republic of China.
authors.forename: Harshit
authors.initials: H
authors.lastname: Bhutani
authors.affiliation: Department of Pathogenic Biology, Chongqing Medical University, Chongqing, 400016, People's Republic of China. yebina@sohu.com.|Research Center for Molecule Medicine and Tumor, Chongqing Medical University, Chongqing, 400016, People's Republic of China. yebina@sohu.com.
authors.forename: Bin
authors.identifier: http://orcid.org/0000-0003-4174-9133
authors.initials: B
authors.lastname: Ye
mesh_terms: D015766:Albendazole / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000871:Anthelmintics / Q000737:chemistry* / Q000494:pharmacology*; D017173:Caenorhabditis elegans / Q000187:drug effects* / Q000502:physiology; D005260:Female; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry* / Q000494:pharmacology; D008297:Male; D011091:Polyesters / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry
chemical_list: D000871:Anthelmintics; D011091:Polyesters; C000589473:polyethylene glycol-poly(lactide-co-glycolide); D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011092:Polyethylene Glycols; D015766:Albendazole; C027186:albendazole sulfoxide
keywords: Albendazole sulfoxide; Caenorhabditis elegans; Drug release; PLGA-PEG-PLGA hydrogel