title: Difference in fatty acids composition of breast adipose tissue in women with breast cancer and benign breast disease.
abstract: BACKGROUND
  Breast cancer is the second most common cancer in the world, and the most frequent cancer among women. Moreover, there are factors that influence the risk for breast cancer including the age, genetic and endocrine factors, and lifestyle.
  
  
  OBJECTIVE
  To evaluate the consumption of fatty acids; compare the fatty acids composition in the breast adipose tissue of women with breast cancer and benign breast disease as well as potential risk factors; and describe the genotypic frequency of the Pro12Ala PPARγ polymorphism.
  
  
  METHODS
  A hospital-based case-control study was conducted including incident cases (n= 38 breast cancer; n= 75 benign breast disease; n= 166 control). Lifestyle features, socioeconomic issues, dietary intake, anthropometry, and blood and tissue data were assessed.
  
  
  RESULTS
  No differences were observed for fatty acids intake. Interestingly, lauric acid (p = 0.001), myristic acid (p = 0.036), stearic acid (p = 0.031), and total saturated fatty acids (SFAs) (p = 0.048) had lower concentrations in BC than in BBD women, while palmitoleic acid (p = 0.022), erucic acid (p = 0.002), total monounsaturated fatty acids (MUFAs) (p = 0.039) and oleic acid/stearic acid ratio (p = 0.015) increased. There was no significant association between PPARγ polymorphism and studied groups (p = 0.977). The age at first full pregnancy (p = 0.004) was significantly associated with the development BC, whereas BMI (p = 0.005); percentage of body fat (p = 0.024); physical activity (p = 0.036); and age at menarche (p = 0.008), at first full pregnancy (p < 0.001), and of first mammogram (p = 0.018) were significantly associated with the development of BBD.
  
  
  CONCLUSIONS
  The results suggest a different fatty acids composition of breast adipose tissue, a biomarker of long-term dietary intake, particularly for SFAs, MUFA and 18: 1 n-9/18: 00 ratio. Our findings also show that are differences in the factors related to the development of BC and BBC.
authors.affiliation: Department of Nutrition and Health. Laboratory of Nutritional Biochemistry. Universidade Federal de Viçosa. Viçosa, MG. lisianelopes@yahoo.com.br.
authors.forename: Lisiane Lopes da
authors.initials: LL
authors.lastname: Conceição
authors.forename: Mariana De Moura
authors.initials: MM
authors.lastname: Dias
authors.forename: Milene Cristine
authors.initials: MC
authors.lastname: Pessoa
authors.forename: Geórgia Das Graças
authors.initials: GD
authors.lastname: Pena
authors.forename: Maria Carolina Santos
authors.initials: MC
authors.lastname: Mendes
authors.forename: Cristiane Vilas Boas
authors.initials: CV
authors.lastname: Neves
authors.forename: Helen Hermana Miranda
authors.initials: HH
authors.lastname: Hermsdorff
authors.forename: Renata Nascimento
authors.initials: RN
authors.lastname: Freitas
authors.forename: Maria do Carmo Gouveia
authors.initials: MD
authors.lastname: Peluzio
mesh_terms: D000273:Adipose Tissue / Q000737:chemistry / Q000378:metabolism*; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001940:Breast / Q000737:chemistry / Q000378:metabolism*; D001941:Breast Diseases / Q000378:metabolism*; D001943:Breast Neoplasms / Q000378:metabolism*; D016022:Case-Control Studies; D004032:Diet; D005227:Fatty Acids / Q000032:analysis / Q000378:metabolism*; D005260:Female; D005838:Genotype; D006801:Humans; D008875:Middle Aged
chemical_list: D015415:Biomarkers; D005227:Fatty Acids
keywords: Fatty acids. Breast  cancer. Benign breast  disease.  PPARγ.  Dietary intake.