title: Predictors of Paravalvular Regurgitation After Transcatheter Aortic Valve Implantation for Aortic Stenosis Using New-Generation Balloon-Expandable SAPIEN 3.
abstract: Paravalvular regurgitation (PVR) is a common and serious complication after transcatheter aortic valve implantation (TAVI). New-generation balloon-expandable SAPIEN 3 has an outer sealing skirt to minimize PVR. However, the predictors of PVR after SAPIEN 3 transcatheter heart valve (THV) implantation have not been well investigated. We sought to clarify the determinants of PVR after TAVI using SAPIEN 3 with quantitative multidetector computed tomography (MDCT) assessment. This study analyzed 281 patients with severe symptomatic aortic stenosis who underwent TAVI using SAPIEN 3. Quantitative assessment of aortic root dimensions and calcium volume for leaflet, annulus, and left ventricular outflow tract were retrospectively performed with MDCT. MDCT nominal area oversizing was calculated using the following formula: % oversizing = (THV nominal area/MDCT derived annular area - 1) × 100. Logistic regression analysis was performed to determine the predictors of PVR greater than or equal to mild. PVR greater than or equal to mild was observed in 19% (53 of 281). Quantity and asymmetry of aortic valve calcium of annulus, left ventricular outflow tract, and leaflet were associated with higher incidence of PVR greater than or equal to mild, except leaflet asymmetry. Lower percentage of THV oversizing was also associated with PVR. Multivariable logistic regression analysis showed that larger calcification volume of annulus and lower percentage of THV oversizing were independent predictors of PVR greater than or equal to mild. These results suggest that prosthesis/annulus incongruence and aortic annulus calcification predicted PVR greater than or equal to mild after TAVI using SAPIEN 3.
authors.affiliation: Heart Center Brandenburg, Department of Cardiology, Medical School Brandenburg, Bernau, Germany.
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Kaneko
authors.affiliation: Heart Center Brandenburg, Department of Cardiology, Medical School Brandenburg, Bernau, Germany.
authors.forename: Frank
authors.initials: F
authors.lastname: Hoelschermann
authors.affiliation: Heart Center Brandenburg, Department of Cardiology, Medical School Brandenburg, Bernau, Germany.
authors.forename: Grit
authors.initials: G
authors.lastname: Tambor
authors.affiliation: Department of Cardiology, Cedars Sinai Medical Center, Los Angeles, California.
authors.forename: Sung-Han
authors.initials: SH
authors.lastname: Yoon
authors.affiliation: Heart Center Brandenburg, Department of Cardiology, Medical School Brandenburg, Bernau, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Neuss
authors.affiliation: Heart Center Brandenburg, Department of Cardiology, Medical School Brandenburg, Bernau, Germany. Electronic address: c.butter@immanuel.de.
authors.forename: Christian
authors.initials: C
authors.lastname: Butter
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001021:Aortic Valve / Q000473:pathology* / Q000601:surgery; D001022:Aortic Valve Insufficiency / Q000000981:diagnostic imaging / Q000453:epidemiology*; D001024:Aortic Valve Stenosis / Q000453:epidemiology / Q000601:surgery*; D002114:Calcinosis / Q000453:epidemiology / Q000601:surgery*; D015897:Comorbidity; D004452:Echocardiography; D005260:Female; D006350:Heart Valve Prosthesis; D006801:Humans; D016015:Logistic Models; D008297:Male; D061330:Multidetector Computed Tomography; D015999:Multivariate Analysis; D011183:Postoperative Complications / Q000000981:diagnostic imaging / Q000453:epidemiology*; D011474:Prosthesis Design; D012189:Retrospective Studies; D012307:Risk Factors; D065467:Transcatheter Aortic Valve Replacement