title: Immune Cell Intolerance for Excess Cholesterol.
abstract: Chronic metabolic challenges have severe consequences on physiological systems. In this issue of Immunity, Ito et al. (2016) show that defects in cholesterol metabolism in CD11c+immune cells result in impaired antigen presentation and ultimately in autoimmune disease.
authors.affiliation: Department of Genetics and Complex Diseases and Sabri Ülker Center, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
authors.forename: Scott B
authors.initials: SB
authors.lastname: Widenmaier
authors.affiliation: Department of Genetics and Complex Diseases and Sabri Ülker Center, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address: ghotamis@hsph.harvard.edu.
authors.forename: Gökhan S
authors.initials: GS
authors.lastname: Hotamışlıgil
mesh_terms: D017951:Antigen Presentation; D001327:Autoimmune Diseases; D002784:Cholesterol; D006801:Humans
chemical_list: D002784:Cholesterol