title: Mildly Increased Mechanical Nociceptive Sensitivity in REV-ERBα Knock-out Mice.
abstract: Nociception is one of the most complex senses that is affected not only by external stimulation but also internal conditions. Previous studies have suggested that circadian rhythm is important in modulating nociception. REV-ERBα knock-out (KO) mice have disrupted circadian rhythm and altered mood-related phenotypes. In this study, we examined the role of REV-ERBα in inflammatory nociception. We found that the nociceptive sensitivity of KO mice was partially enhanced in mechanical nociception. However, this partial alteration was independent of the circadian rhythm. Taken together, deletion of REV-ERBα induced a mild change in mechanical nociceptive sensitivity but this alteration was not dependent on the circadian rhythm.
authors.affiliation: Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 08826, Korea.
authors.forename: Jaehyun
authors.initials: J
authors.lastname: Lee
authors.affiliation: Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 08826, Korea.
authors.forename: Hyoung-Gon
authors.initials: HG
authors.lastname: Ko
authors.affiliation: Department of Brain and Cognitive Science, DGIST, Daegu 42988, Korea.
authors.forename: Kyungjin
authors.initials: K
authors.lastname: Kim
authors.affiliation: Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 08826, Korea.
authors.forename: Bong-Kiun
authors.initials: BK
authors.lastname: Kaang
keywords: Circadian rhythm; Inflammatory pain; Nociception; REV-ERBα