title: Low Serum Levels of Prealbumin, Retinol Binding Protein, and Retinol Are Frequent in Adult Type 1 Diabetic Patients.
abstract: Aim.To determine the serum prealbumin (PA), retinol binding protein (RBP), and retinol levels in adult patients with type 1 diabetes (T1D) and to analyze some factors related to those levels.Methods.A total of 93 patients (47 women) were studied. Age, gender, BMI, duration of diabetes, chronic complications, HbA1c, lipid profile, creatinine, albumin, PA, RBP, and retinol were recorded. High and low parameter groups were compared by Mann-WhitneyUandχ2tests. Correlation between parameters was analyzed by Spearman's test. Odds of low levels were analyzed by univariate logistic regression and included in the multivariate analysis when significant.Results.49.5%, 48.4%, and 30.1% of patients displayed serum PA, RBP, and retinol levels below normal values, respectively. A high correlation (Rho > 0.8) between PA, RBP, and retinol serum levels was found. Patients presenting low levels of any of them were predominantly women, normal-weighted, and with lower levels of triglycerides and serum creatinine. No differences in age, macrovascular complications, duration of diabetes, or HbA1c values were observed when comparing low and normal parameter groups.Conclusion.Low serum levels of PA, RBP, and retinol are frequent in T1D adult patients. This alteration is influenced by female sex and serum creatinine and triglyceride levels.
authors.affiliation: Department of Endocrinology and Nutrition, Complejo Hospitalario de Navarra, Instituto de Investigación Sanitaria de Navarra (IdiSNA), Calle Irunlarrea 3, Pamplona, 31008 Navarra, Spain.
authors.forename: Luis
authors.identifier: 0000-0001-7789-133X
authors.initials: L
authors.lastname: Forga
authors.affiliation: Department of Digestive System, Complejo Hospitalario de Navarra, Calle Irunlarrea 3, Pamplona, 31008 Navarra, Spain.
authors.forename: Federico
authors.initials: F
authors.lastname: Bolado
authors.affiliation: Department of Endocrinology and Nutrition, Complejo Hospitalario de Navarra, Instituto de Investigación Sanitaria de Navarra (IdiSNA), Calle Irunlarrea 3, Pamplona, 31008 Navarra, Spain.
authors.forename: María José
authors.initials: MJ
authors.lastname: Goñi
authors.affiliation: Navarrabiomed, Fundación Miguel Servet, Calle Irunlarrea 3, Pamplona, 31008 Navarra, Spain.
authors.forename: Ibai
authors.initials: I
authors.lastname: Tamayo
authors.affiliation: Navarrabiomed, Fundación Miguel Servet, Red de Investigación en Servicios Sanitarios en Enfermedades Crónicas (REDISSEC), Calle Irunlarrea 3, Pamplona, 31008 Navarra, Spain.
authors.forename: Berta
authors.initials: B
authors.lastname: Ibáñez
authors.affiliation: Department of Digestive System, Complejo Hospitalario de Navarra, Calle Irunlarrea 3, Pamplona, 31008 Navarra, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Prieto
mesh_terms: D000328:Adult; D000367:Age Factors; D015992:Body Mass Index; D003404:Creatinine / Q000097:blood; D048909:Diabetes Complications / Q000097:blood*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D005260:Female; D006801:Humans; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011228:Prealbumin / Q000737:chemistry*; D054840:Retinol-Binding Proteins, Cellular / Q000097:blood*; D014280:Triglycerides / Q000097:blood; D014801:Vitamin A / Q000097:blood*
chemical_list: D011228:Prealbumin; C518456:RBP1 protein, human; D054840:Retinol-Binding Proteins, Cellular; D014280:Triglycerides; D014801:Vitamin A; D003404:Creatinine