title: Biomonitoring of gasoline station attendants exposed to benzene: Effect of gender.
abstract: Women are employed in increasing numbers as gasoline station attendants, a work category with risk of exposure to benzene. We have assessed the effect of gender on biomarkers of occupational benzene exposure. Gasoline station attendants (20 men and 20 women) and 40 control individuals (20 men and 20 women) with no history of occupational benzene exposure were evaluated. Benzene exposure was monitoring by environmental and biological measurements. Urinary trans,trans-muconic acid levels, well-known genetic and hematological alterations linked to benzene exposure, and non-cancer effects on the immune, hepatic, and renal systems were investigated. Our results suggest a potential effect of gender on some effects of occupational benzene exposure, particularly the hematological parameters and trans,trans-muconic acid levels. Despite limitations of our study, our findings provide important considerations about occupational exposure of women to benzene and may contribute to the development of occupational protection standards.
authors.affiliation: Laboratory of Toxicology (LATOX), Department of Analysis, Pharmacy Faculty, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil; Specialized Faculty in the Health Area of Rio Grande do Sul (FASURGS), Passo Fundo, RS, Brazil.
authors.forename: Angela M
authors.initials: AM
authors.lastname: Moro
authors.affiliation: Laboratory of Toxicology (LATOX), Department of Analysis, Pharmacy Faculty, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Natália
authors.initials: N
authors.lastname: Brucker
authors.affiliation: Laboratory of Toxicology (LATOX), Department of Analysis, Pharmacy Faculty, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Mariele F
authors.initials: MF
authors.lastname: Charão
authors.affiliation: Laboratory of Toxicology (LATOX), Department of Analysis, Pharmacy Faculty, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Marília
authors.initials: M
authors.lastname: Baierle
authors.affiliation: Laboratory of Toxicology (LATOX), Department of Analysis, Pharmacy Faculty, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil; Post-graduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Elisa
authors.initials: E
authors.lastname: Sauer
authors.affiliation: Laboratory of Toxicology (LATOX), Department of Analysis, Pharmacy Faculty, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil; Post-graduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Goethel
authors.affiliation: Laboratory of Toxicology (LATOX), Department of Analysis, Pharmacy Faculty, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Anelise
authors.initials: A
authors.lastname: Barth
authors.affiliation: Laboratory of Toxicology (LATOX), Department of Analysis, Pharmacy Faculty, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil; Post-graduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Sabrina N
authors.initials: SN
authors.lastname: Nascimento
authors.affiliation: Laboratory of Toxicology (LATOX), Department of Analysis, Pharmacy Faculty, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil; Post-graduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Bruna
authors.initials: B
authors.lastname: Gauer
authors.affiliation: Laboratory of Toxicology (LATOX), Department of Analysis, Pharmacy Faculty, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Juliano
authors.initials: J
authors.lastname: Durgante
authors.affiliation: Chemistry Department, Pontifical Catholic University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Beatriz S
authors.initials: BS
authors.lastname: Amaral
authors.affiliation: Chemistry Institute, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Francisco R A
authors.initials: FR
authors.lastname: Neto
authors.affiliation: Chemistry Department, Pontifical Catholic University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Adriana
authors.initials: A
authors.lastname: Gioda
authors.affiliation: Laboratory of Toxicology (LATOX), Department of Analysis, Pharmacy Faculty, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil; Post-graduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil. Electronic address: solange.garcia@ufrgs.br.
authors.forename: Solange C
authors.initials: SC
authors.lastname: Garcia
mesh_terms: D001554:Benzene / Q000633:toxicity*; D004784:Environmental Monitoring / Q000379:methods*; D005260:Female; D005742:Gasoline; D006801:Humans; D008297:Male; D016273:Occupational Exposure
chemical_list: D005742:Gasoline; D001554:Benzene
keywords: Gasoline station attendants; Gender; Genotoxicity; Hematotoxicity; Non-cancer effects; Occupational benzene exposure