title: Bronchoconstriction Induces Structural and Functional Airway Alterations in Non-sensitized Rats.
abstract: The impact of mechanical forces on pathogenesis of airway remodeling and the functional consequences in asthma remains to be fully established. In the present study, we investigated the effect of repeated bronchoconstriction induced by methacholine (MCh) on airway remodeling and airway hyperresponsiveness (AHR) in rats with or without sensitization to an external allergen. We provide evidence that repeated bronchoconstriction, using MCh, alone induces airway inflammation and remodeling as well as AHR in non-allergen-sensitized rats. Also, we found that the airways are structurally and functionally altered by bronchoconstriction induced by either allergen or MCh in allergen-sensitized animals. This finding provides a new animal model for the development of airway remodeling and AHR in mammals and can be used for studying the complex reciprocal relationship between bronchoconstriction and airway inflammation. Further studies on presented animal models are required to clarify the exact mechanisms underlying airway remodeling due to bronchoconstriction and the functional consequences.
authors.affiliation: Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Nasr Bridge, Jalal Al Ahmad Highway, Tehran, Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Eslami-Behroozi
authors.affiliation: Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Nasr Bridge, Jalal Al Ahmad Highway, Tehran, Iran.
authors.forename: Saeed
authors.initials: S
authors.lastname: Pazhoohan
authors.affiliation: Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Nasr Bridge, Jalal Al Ahmad Highway, Tehran, Iran.
authors.forename: Ehsan
authors.initials: E
authors.lastname: Aref
authors.affiliation: Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Nasr Bridge, Jalal Al Ahmad Highway, Tehran, Iran.
authors.forename: Leila
authors.initials: L
authors.lastname: Zare
authors.affiliation: Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Nasr Bridge, Jalal Al Ahmad Highway, Tehran, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Javan
authors.affiliation: Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Nasr Bridge, Jalal Al Ahmad Highway, Tehran, Iran.
authors.forename: Sohrab
authors.initials: S
authors.lastname: Hajizadeh
authors.affiliation: Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Nasr Bridge, Jalal Al Ahmad Highway, Tehran, Iran. raoufy@modares.ac.ir.|Chronic Respiratory Diseases Research Center (CRDRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. raoufy@modares.ac.ir.
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Raoufy
mesh_terms: D000199:Actins / Q000378:metabolism; D056151:Airway Remodeling / Q000187:drug effects*; D000485:Allergens / Q000276:immunology; D000818:Animals; D016084:Bronchoconstriction / Q000187:drug effects*; D016085:Bronchoconstrictor Agents / Q000494:pharmacology*; D004804:Eosinophils / Q000473:pathology; D007249:Inflammation / Q000139:chemically induced / Q000473:pathology*; D008168:Lung / Q000473:pathology; D008297:Male; D055595:Mechanical Phenomena; D016210:Methacholine Chloride / Q000494:pharmacology*; D010047:Ovalbumin / Q000276:immunology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012130:Respiratory Hypersensitivity / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology
chemical_list: D000199:Actins; D000485:Allergens; D016085:Bronchoconstrictor Agents; D016210:Methacholine Chloride; D010047:Ovalbumin; C498862:Acta2 protein, rat
keywords: Airway hyperresponsiveness; Airway remodeling; Asthma; Mechanical forces