title: Glomerular Lesions in Proteinuric Miniature Schnauzer Dogs.
abstract: Miniature Schnauzer dogs are predisposed to idiopathic hypertriglyerceridemia, which increases risk for diseases such as pancreatitis and gallbladder mucocele. Recently, elevated triglyceride concentrations have been associated with proteinuria in this breed, although it is difficult to determine which abnormality is primary. Retrospective review of renal tissue from 27 proteinuric Miniature Schnauzers revealed that 20 dogs had ultrastructural evidence of osmophilic globules consistent with lipid in glomerular tufts. Seven of these dogs had lipid thromboemboli in glomerular capillary loops that distorted their shape and compressed circulating erythrocytes. Triglyceride concentrations were reported in 6 of these 7 dogs, and all were hypertriglyceridemic. In addition, glomerular lipidosis (defined as accumulation of foam cells within peripheral capillary loops) was identified in a single dog. The remaining 12 dogs had smaller amounts of lipid that could only be identified ultrastructurally. Neither signalment data nor clinicopathologic parameters (serum albumin, serum creatinine, urine protein-to-creatinine ratio, and blood pressure) differed among the various types of lipid lesions. During the time course of this study, all dogs diagnosed with glomerular lipid thromboemboli were Miniature Schnauzers, underscoring the importance of recognizing these clear spaces within capillary loops as lipid.
authors.affiliation: 1 Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, Minneapolis, MN, USA.
authors.forename: E
authors.initials: E
authors.lastname: Furrow
authors.affiliation: 2 Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA.
authors.forename: G E
authors.initials: GE
authors.lastname: Lees
authors.affiliation: 3 Athens Veterinary Diagnostic Laboratory, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.
authors.forename: C A
authors.initials: CA
authors.lastname: Brown
authors.affiliation: 4 Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA.
authors.forename: R E
authors.initials: RE
authors.lastname: Cianciolo
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005260:Female; D015228:Hypertriglyceridemia / Q000473:pathology / Q000662:veterinary; D007678:Kidney Glomerulus / Q000473:pathology*; D008297:Male; D011507:Proteinuria / Q000473:pathology / Q000662:veterinary*; D012189:Retrospective Studies; D014280:Triglycerides / Q000097:blood
chemical_list: D014280:Triglycerides
keywords: dogs; glomerulonephropathy; hyperlipidemia; hypertriglyceridemia; proteinuria