title: A multitrait GWAS sheds light on insulin resistance.
abstract: A genome-wide study of fasting insulin, HDL cholesterol and triglycerides, designed to depict insulin resistance, identified 53 independent loci associated with a limited capacity to store fat in a healthy way. The increased power of this multitrait approach provides insights into an otherwise difficult-to-grasp phenotype.
authors.affiliation: Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
authors.forename: Iris M
authors.initials: IM
authors.lastname: Heid
authors.affiliation: Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Winkler
mesh_terms: D050154:Adiposity / Q000235:genetics*; D001786:Blood Glucose / Q000378:metabolism; D008076:Cholesterol, HDL / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology; D005215:Fasting; D056426:Genetic Loci; D055106:Genome-Wide Association Study; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D009765:Obesity / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology; D010641:Phenotype; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D007328:Insulin; D014280:Triglycerides