title: Physiological Study on Association between Nicotinamide N-Methyltransferase Gene Polymorphisms and Hyperlipidemia.
abstract: Nicotinamide N-methyltransferase (NNMT) catalyzes the methylation of nicotinamide. Our previous works indicate that NNMT is involved in the body mass index and energy metabolism, and recently the association between a SNP (rs694539) ofNNMTand a variety of cardiovascular diseases was reported. At present, more than 200NNMTsingle nucleotide polymorphisms (SNPs) have been identified in the databases of the human genome projects; however, the association between rs694539 variation and hyperlipidemia has not been reported yet, and whether there are any SNPs inNNMTsignificantly associated with hyperlipidemia is still unclear. In this paper, we selected 19 SNPs inNNMTas the tagSNPs using Haploview software (Haploview 4.2) first and then performed a case-control study to observe the association between these tagSNPs and hyperlipidemia and finally applied physiological approaches to explore the possible mechanisms through which theNNMTpolymorphism induces hyperlipidemia. The results show that a SNP (rs1941404) inNNMTis significantly associated with hyperlipidemia, and the influence of rs1941404 variation on the resting energy expenditure may be the possible mechanism for rs1941404 variation to induce hyperlipidemia.
authors.affiliation: Key Lab of Training, Monitoring and Intervention of Aquatic Sports of General Administration of Sport of China, Institute of Physical Education, Jiangxi Normal University, Nanchang, China.
authors.forename: Xiao-Juan
authors.initials: XJ
authors.lastname: Zhu
authors.affiliation: Key Lab of Training, Monitoring and Intervention of Aquatic Sports of General Administration of Sport of China, Institute of Physical Education, Jiangxi Normal University, Nanchang, China.
authors.forename: Ya-Jun
authors.initials: YJ
authors.lastname: Lin
authors.affiliation: Key Lab of Training, Monitoring and Intervention of Aquatic Sports of General Administration of Sport of China, Institute of Physical Education, Jiangxi Normal University, Nanchang, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.affiliation: Key Lab of Training, Monitoring and Intervention of Aquatic Sports of General Administration of Sport of China, Institute of Physical Education, Jiangxi Normal University, Nanchang, China.
authors.forename: Ya-Hui
authors.initials: YH
authors.lastname: Wang
authors.affiliation: Key Lab of Training, Monitoring and Intervention of Aquatic Sports of General Administration of Sport of China, Institute of Physical Education, Jiangxi Normal University, Nanchang, China.
authors.forename: Li-Qiang
authors.initials: LQ
authors.lastname: Qiu
authors.affiliation: Key Lab of Training, Monitoring and Intervention of Aquatic Sports of General Administration of Sport of China, Institute of Physical Education, Jiangxi Normal University, Nanchang, China.
authors.forename: Can-Xin
authors.initials: CX
authors.lastname: Cai
authors.affiliation: Key Lab of Training, Monitoring and Intervention of Aquatic Sports of General Administration of Sport of China, Institute of Physical Education, Jiangxi Normal University, Nanchang, China.
authors.forename: Qun
authors.initials: Q
authors.lastname: Xiong
authors.affiliation: Key Lab of Training, Monitoring and Intervention of Aquatic Sports of General Administration of Sport of China, Institute of Physical Education, Jiangxi Normal University, Nanchang, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Chen
authors.affiliation: Key Lab of Training, Monitoring and Intervention of Aquatic Sports of General Administration of Sport of China, Institute of Physical Education, Jiangxi Normal University, Nanchang, China.
authors.forename: Li-Hui
authors.initials: LH
authors.lastname: Chen
authors.affiliation: Key Lab of Training, Monitoring and Intervention of Aquatic Sports of General Administration of Sport of China, Institute of Physical Education, Jiangxi Normal University, Nanchang, China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Zhou
authors.affiliation: Key Lab of Training, Monitoring and Intervention of Aquatic Sports of General Administration of Sport of China, Institute of Physical Education, Jiangxi Normal University, Nanchang, China; Key Laboratory of Functional Small Organic Molecule, Ministry of Education, Jiangxi Normal University, Nanchang, China.
authors.forename: Jiang-Hua
authors.identifier: 0000-0001-9221-0387
authors.initials: JH
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D030541:Databases, Genetic; D004734:Energy Metabolism / Q000235:genetics*; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000201:enzymology / Q000235:genetics / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D050903:Nicotinamide N-Methyltransferase / Q000235:genetics / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D012984:Software
chemical_list: C494406:NNMT protein, human; D050903:Nicotinamide N-Methyltransferase