title: The role of prostate tumor overexpressed 1 in cancer progression.
abstract: Prostate-Tumor-Overexpressed-1 (PTOV1) is a conserved adaptor protein discovered as overexpressed in prostate cancer. Since its discovery, the number of binding partners and associated cellular functions has increased and helped to identify PTOV1 as regulator of gene expression at transcription and translation levels. Its overexpression is associated with increased tumor grade and proliferation in prostate cancer and other neoplasms, including breast, ovarian, nasopharyngeal, squamous laryngeal, hepatocellular and urothelial carcinomas. An important contribution to higher levels of PTOV1 in prostate tumors is given by the frequent rate of gene amplifications, also found in other tumor types. The recent resolution of the structure by NMR of the PTOV domain in PTOV2, also identified as Arc92/ACID1/MED25, has helped to shed light on the functions of PTOV1 as a transcription factor. In parallel, by studying its interaction with RACK1, we have discovered PTOV1 action in promoting mRNAs translation. Here, we will focus on the role of PTOV1 in cancer, re-examine its pro-oncogenic effects and re-evaluate the most relevant interactions and evidences of its cellular functions. The data are used to formulate a model for the mechanisms of action of PTOV1 in line with its recently described activities and cellular pathways modulated in cancer.
authors.affiliation: Biomedical Research Group of Urology, Vall d'Hebron Research Institute, Pg. Vall d'Hebron 119-129, 08035 Barcelona, Spain.|Universitat Autònoma de Barcelona, Spain.
authors.forename: Verónica
authors.initials: V
authors.lastname: Cánovas
authors.affiliation: Biomedical Research in Cancer Stem Cells, Vall d'Hebron Research Institute, Pg. Vall d'Hebron 119-129, 08035 Barcelona, Spain.|Universitat Autònoma de Barcelona, Spain.
authors.forename: Matilde
authors.initials: M
authors.lastname: Lleonart
authors.affiliation: Biomedical Research Group of Urology, Vall d'Hebron Research Institute, Pg. Vall d'Hebron 119-129, 08035 Barcelona, Spain.|Deparment of Urology, Vall d'Hebron Hospital, Pg. Vall d'Hebron 119-129, 08035 Barcelona, Spain.|Universitat Autònoma de Barcelona, Spain.
authors.forename: Juan
authors.initials: J
authors.lastname: Morote
authors.affiliation: Biomedical Research Group of Urology, Vall d'Hebron Research Institute, Pg. Vall d'Hebron 119-129, 08035 Barcelona, Spain.|Universitat Autònoma de Barcelona, Spain.
authors.forename: Rosanna
authors.initials: R
authors.lastname: Paciucci
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics* / Q000378:metabolism; D018450:Disease Progression; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008957:Models, Genetic; D009363:Neoplasm Proteins / Q000235:genetics* / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D011485:Protein Binding; D015398:Signal Transduction / Q000235:genetics; D048868:Adaptor Proteins, Signal Transducing
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; C425183:PTOV1 protein, human; D048868:Adaptor Proteins, Signal Transducing
keywords: PTOV1; cancer progression; cancer stem cells; prostate cancer; transcription