title: Determinants of pre-transplantation pectoralis muscle area (PMA) and post-transplantation change in PMA in lung transplant recipients.
abstract: This study aimed to determine predictors of pectoralis muscle area (PMA) and assess change in PMA following lung transplantation and its relationship to outcomes.
  
  
  
  A retrospective review of 88 lung transplant recipients at a single center was performed. PMA was determined on a single axial slice from chest computerized tomography. Pectoralis muscle index (PMI) was calculated from the PMA divided by the height squared.
  
  
  
  PMI decreased post-transplantation (8.1±2.8 cm2/m2pre-transplantation, 7.5±2.9 cm2/m2at 6 months, and 7.6±2.7 cm2/m2at 12 months, P<.05). Chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD) were predictors of pre-transplant PMI (β=-2.3, P=.001 for COPD; β=2.1, P<.001 for ILD) and percent change in PMI at 12 months post-transplantation relative to baseline (β=19.2, P=.04 for COPD; β=-20.1, P=.01 for ILD). Patients in the highest quartile for PMI change at 12 months had fewer ventilator days compared with patients in the other quartiles (P=.03).
  
  
  
  Underlying diagnosis was a significant predictor of both pre-transplantation PMI and change in PMI post-transplantation. Further studies of PMI are needed to determine its clinical utility in predicting outcomes following lung transplantation.
authors.affiliation: Section of Pulmonary, Critical Care and Sleep, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
authors.forename: Van
authors.initials: V
authors.lastname: Hoang
authors.affiliation: Section of Pulmonary, Critical Care and Sleep, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
authors.forename: Gloria W
authors.initials: GW
authors.lastname: Li
authors.affiliation: Section of Pulmonary, Critical Care and Sleep, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.|USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, Houston, TX, USA.
authors.forename: Christina C
authors.initials: CC
authors.lastname: Kao
authors.affiliation: Section of Pulmonary, Critical Care and Sleep, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
authors.forename: Goutham
authors.initials: G
authors.lastname: Dronavalli
authors.affiliation: Section of Pulmonary, Critical Care and Sleep, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
authors.forename: Amit D
authors.identifier: 0000-0003-4828-4041
authors.initials: AD
authors.lastname: Parulekar
mesh_terms: D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008171:Lung Diseases / Q000601:surgery*; D016040:Lung Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D010369:Pectoralis Muscles / Q000000981:diagnostic imaging / Q000473:pathology*; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D014057:Tomography, X-Ray Computed / Q000379:methods; D066027:Transplant Recipients
keywords: body composition; body mass index; chronic obstructive pulmonary disease; interstitial lung disease; sarcopenia