title: Ligand trap for the activin type IIA receptor. The long-sought drug to overcome the calcification paradox in CKD?
abstract: The chronic kidney disease-mineral and bone disorder syndrome illustrates the association between a disturbed physiological bone turnover/mineralization and pathologic vascular mineralization; the so-called calcification paradox. This implies that treatments aimed at curing bone disorders might have serious implications for cardiovascular health and vice versa. Hence, there is an urgent need for treatments that are able to break through this cross-talk. Hereto, compounds such as those interfering with activin type IIA receptor signaling and acting upstream of the Wnt-β-catenin pathway are of particular interest.
authors.affiliation: Department of Biomedical Sciences, Antwerp University, Laboratory of Pathophysiology, Wilrijk, Belgium.
authors.forename: Anja
authors.initials: A
authors.lastname: Verhulst
authors.affiliation: Department of Immunology and Microbiology, Laboratory of Nephrology, KU Leuven, Leuven, Belgium; Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium.
authors.forename: Pieter
authors.initials: P
authors.lastname: Evenepoel
authors.affiliation: Department of Biomedical Sciences, Antwerp University, Laboratory of Pathophysiology, Wilrijk, Belgium. Electronic address: patrick.dhaese@uantwerpen.be.
authors.forename: Patrick C
authors.initials: PC
authors.lastname: D'Haese
mesh_terms: D029404:Activin Receptors; D028341:Activins; D002113:Calcification, Physiologic; D051436:Renal Insufficiency, Chronic; D061205:Vascular Calcification; D051176:beta Catenin
chemical_list: D051176:beta Catenin; D028341:Activins; D029404:Activin Receptors