title: Comparison of Conventional and Hypofractionated Radiotherapy in Breast Cancer Patients in Terms of 5-Year Survival, Locoregional Recurrence, Late Skin Complications and Cosmetic Results
abstract: Bckground: Adjuvant radiation therapy is commonly administered following breast-conserving surgery for breast
  cancer patients. Hypofractionated radiotherapy can significantly reduce the waiting time for radiotherapy, working
  load on machines, patient visits to radiotherapy departments and medical costs. Material/Methods: Fifty-two patients
  with operable breast cancer (pT1-3pN0M0) who underwent breast conservation surgery in Tehran Cancer Institute
  during January 2011 to January 2012, were randomly assigned to undergo radiotherapy in two arms (hypofractionated
  radiotherapy arm with 30 patients, dose 42.5 Gy in 16 fractions; and conventional radiotherapy arm with 22 patients,
  dose 50 Gy in 25 fractions). W compared these two groups in terms of overall survival, locoregional control, late skin
  complications and cosmetic results. Results: At a median follow-up of 52.4 months (range: 0–64 months), the follow-up
  rate was 82.6%. Overall, after 60 months, there was no detectable significant differences between groups regarding
  cosmetic results (p = 0.857), locoregional control or survival. Conclusions: The results confirm that hypofractionated
  radiotherapy with a subsequent boost is as effective as conventional radiotherapy, is well-tolerated and can be used as
  an alternative treatment method following breast conservation surgery.
authors.affiliation: Radiation Oncology Research Center, Tehran University of medical Sciences, Iran. Email: mohammadtahamtan@sbmu.ac.ir
authors.forename: Farnaz
authors.initials: F
authors.lastname: Amouzegar Hashemi
authors.forename: Mohammadreza
authors.initials: M
authors.lastname: Barzegartahamtan
authors.forename: Reza Ali
authors.initials: RA
authors.lastname: Mohammadpour
authors.forename: Ahmadreza
authors.initials: A
authors.lastname: Sebzari
authors.forename: Bita
authors.initials: B
authors.lastname: Kalaghchi
authors.forename: Peiman
authors.initials: P
authors.lastname: Haddad
keywords: Breast cancer; hypofractionated radiotherapy; late skin toxicity; survival