title: Independent prognostic role of PD-L1expression in patients with esophageal squamous cell carcinoma.
abstract: Accumulating evidence has shown that PD-L1 expression is associated with clinicopathological features in various human malignancies. We searched for correlations between PD-L1 expression and clinicopathological data in esophageal squamous cell carcinoma (ESCC) patients. PD-L1 expression in primary tumors from 278 patients was evaluated using immunohistochemistry (IHC) in ESCC tissue microarray. Survival curves were constructed by using the Kaplan-Meier method. Univariate and multivariate Cox proportional hazard regression models were performed to identify associations with outcome variables. Overall, tumoral PD-L1 expression (≥10%, 20% or 30% as cut-off value) was associated with favorable DFS and OS upon multivariate analysis. When the patients stratified into stage I-II (168, 60.4%) and stage III-IV (110, 39.6%), or with lymph node metastasis (133, 47.8%), the prognostic role was not consistent. In patients with stage I-II disease, tumoral PD-L1 expression (≥5%, 10%, 20% or 30%) was associated with better DFS and OS upon multivariate analysis. In patients without lymph node metastasis, tumoral PD-L1 expression (≥1%, 5%, 10%, 20%, or 30%) was associated with improved DFS and OS in univariate or multivariate analysis. However, PD-L1 expression was not correlated with prognosis in patients with stage III-IV disease or with lymph node metastasis. Our results for the first time showed the prognostic role of tumoral PD-L1 expression was variable in different stages and lymph node status of ESCC. Tumoral PD-L1 expression was independent favorable predictor in ESCC patients with Stage I-II disease or without lymph node metastasis, not in stage III-IV or lymph node metastasis.
authors.affiliation: Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China.
authors.forename: Dongxian
authors.initials: D
authors.lastname: Jiang
authors.affiliation: Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Song
authors.affiliation: Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China.
authors.forename: Haixing
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Huang
authors.affiliation: Department of thoracic surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Hou
authors.affiliation: Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China.
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China.
authors.forename: Yifan
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China.
authors.forename: Akesu
authors.initials: A
authors.lastname: Sujie
authors.affiliation: Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China.
authors.forename: Haiying
authors.initials: H
authors.lastname: Zeng
authors.affiliation: Department of thoracic surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China.
authors.forename: Lijie
authors.initials: L
authors.lastname: Tan
authors.affiliation: Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China.|Department of Pathology, School of Basic Medical Sciences & Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China.
authors.forename: Yingyong
authors.initials: Y
authors.lastname: Hou
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D060890:B7-H1 Antigen / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000276:immunology* / Q000401:mortality / Q000556:secondary / Q000628:therapy; D016009:Chi-Square Distribution; D018450:Disease Progression; D018572:Disease-Free Survival; D004938:Esophageal Neoplasms / Q000276:immunology* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D000077277:Esophageal Squamous Cell Carcinoma; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D046888:Tissue Array Analysis; D016896:Treatment Outcome
chemical_list: D060890:B7-H1 Antigen; D014408:Biomarkers, Tumor; C423236:CD274 protein, human
keywords: ESCC; PD-L1 expression; clinical stage; lymph node metastasis; prognostic marker