title: Attention bias in older women with remitted depression is associated with enhanced amygdala activity and functional connectivity.
abstract: Cognitive bias is a common characteristic of major depressive disorder (MDD) and is posited to remain during remission and contribute to recurrence risk. Attention bias may be related to enhanced amygdala activity or altered amygdala functional connectivity in depression. The current study examined attention bias, brain activity for emotional images, and functional connectivity in post-menopausal women with and without a history of major depression.
  
  
  
  Attention bias for emotionally valenced images was examined in 33 postmenopausal women with (n=12) and without (n=21) a history of major depression using an emotion dot probe task during fMRI. Group differences in amygdala activity and functional connectivity were assessed using fMRI and examined for correlations to attention performance.
  
  
  
  Women with a history of MDD showed greater attentional bias for negative images and greater activity in brain areas including the amygdala for both positive and negative images (pcorr <0.001) than women without a history of MDD. In all participants, amygdala activity for negative images was correlated with attention facilitation for emotional images. Women with a history of MDD had significantly greater functional connectivity between the amygdala and hippocampal complex. In all participants amygdala-hippocampal connectivity was positively correlated with attention facilitation for negative images.
  
  
  
  Small sample with unbalanced groups.
  
  
  
  These findings provide evidence for negative attentional bias in euthymic, remitted depressed individuals. Activity and functional connectivity in limbic and attention networks may provide a neurobiological basis for continued cognitive bias in remitted depression.
authors.affiliation: Center for Cognitive Medicine, Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, United States; University of Vermont, Burlington, VT, United States.
authors.forename: Kimberly
authors.initials: K
authors.lastname: Albert
authors.affiliation: Center for Cognitive Medicine, Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, United States.
authors.forename: Violet
authors.initials: V
authors.lastname: Gau
authors.affiliation: Center for Cognitive Medicine, Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, United States; Geriatric Research, Education, and Clinical Center, Tennessee Valley VA Health System, Nashville TN, United States.
authors.forename: Warren D
authors.initials: WD
authors.lastname: Taylor
authors.affiliation: Center for Cognitive Medicine, Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, United States; Geriatric Research, Education, and Clinical Center, Tennessee Valley VA Health System, Nashville TN, United States. Electronic address: Paul.Newhouse@Vanderbilt.edu.
authors.forename: Paul A
authors.initials: PA
authors.lastname: Newhouse
mesh_terms: D000368:Aged; D000679:Amygdala / Q000503:physiopathology*; D001288:Attention; D003865:Major Depressive Disorder / Q000503:physiopathology* / Q000523:psychology*; D004644:Emotions / Q000502:physiology; D005260:Female; D006624:Hippocampus / Q000503:physiopathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009434:Neural Pathways / Q000503:physiopathology*; D010775:Photic Stimulation; D011597:Psychomotor Performance
keywords: Attention; Brain imaging/neuroimaging; Cognition; Depression; Functional MRI