title: Reproducibility of superficial white matter tracts using diffusion-weighted imaging tractography.
abstract: Human brain connection map is far from being complete. In particular the study of the superficial white matter (SWM) is an unachieved task. Its description is essential for the understanding of human brain function and the study of pathogenesis triggered by abnormal connectivity. In this work we automatically created a multi-subject atlas of SWM diffusion-based bundles of the whole brain. For each subject, the complete cortico-cortical tractogram is first split into sub-tractograms connecting pairs of gyri. Then intra-subject shape-based fiber clustering performs compression of each sub-tractogram into a set of bundles. Proceeding further with shape-based clustering provides a match of the bundles across subjects. Bundles found in most of the subjects are instantiated in the atlas. To increase robustness, this procedure was performed with two independent groups of subjects, in order to discard bundles without match across the two independent atlases. Finally, the resulting intersection atlas was projected on a third independent group of subjects in order to filter out bundles without reproducible and reliable projection. The final multi-subject diffusion-based U-fiber atlas is composed of 100 bundles in total, 50 per hemisphere, from which 35 are common to both hemispheres.
authors.affiliation: Faculty of Engineering, University of Concepción, Concepción, Chile.
authors.forename: Miguel
authors.initials: M
authors.lastname: Guevara
authors.affiliation: Faculty of Engineering, University of Concepción, Concepción, Chile.
authors.forename: Claudio
authors.initials: C
authors.lastname: Román
authors.affiliation: Neurospin, I2BM, CEA, Gif-sur-Yvette, France; APHP, Pôle de Psychiatrie, DHU PePsy, INSERM U955 Eq. 15 "Psychiatrie Translationnelle", Université Paris Est, Créteil, France.
authors.forename: Josselin
authors.initials: J
authors.lastname: Houenou
authors.affiliation: CATI Multicenter Neuroimaging Platform, France; Neurospin, I2BM, CEA, Gif-sur-Yvette, France.
authors.forename: Delphine
authors.initials: D
authors.lastname: Duclap
authors.affiliation: CATI Multicenter Neuroimaging Platform, France; Neurospin, I2BM, CEA, Gif-sur-Yvette, France.
authors.forename: Cyril
authors.initials: C
authors.lastname: Poupon
authors.affiliation: CATI Multicenter Neuroimaging Platform, France; Neurospin, I2BM, CEA, Gif-sur-Yvette, France.
authors.forename: Jean François
authors.initials: JF
authors.lastname: Mangin
authors.affiliation: Faculty of Engineering, University of Concepción, Concepción, Chile. Electronic address: pguevara@udec.cl.
authors.forename: Pamela
authors.initials: P
authors.lastname: Guevara
mesh_terms: D000328:Adult; D001271:Atlases as Topic; D001921:Brain / Q000000981:diagnostic imaging*; D056324:Diffusion Tensor Imaging / Q000379:methods* / Q000592:standards; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods* / Q000592:standards; D008297:Male; D015203:Reproducibility of Results; D066127:White Matter / Q000000981:diagnostic imaging*; D055815:Young Adult
keywords: Bundle atlas; Diffusion MRI; Fiber clustering; Short association fibers; Tractography segmentation; White matter tracts