title: Impact of diabetes on mortality in peripheral artery disease: a meta-analysis.
abstract: BACKGROUND
  There are accumulating studies showing the association between diabetes and all-cause mortality in peripheral vascular disease. However, the results in these studies are conflicting regarding the impact of diabetes on outcome.
  
  
  OBJECTIVE
  Diabetes is associated with increased risk of mortality in peripheral artery disease.
  
  
  METHODS
  Using MEDLINE and Scopus, we searched for studies published before January 2016. Additionally, studies were identified by manual search of references of original articles or review studies on this topic. Of the 1072 initially identified records, 21 studies with 15,857 patients were included in the final analysis.
  
  
  RESULTS
  Diabetes was associated with a statistically significant increased risk of all-cause mortality (odds ratio: 1.89, 95% confidence interval: 1.51-2.35, P < 0.001), without detected publication bias (Egger bias = 0.75, P = 0.631). The stronger effect on outcome was obtained in patients with critical limb ischemia (odds ratio: 2.38, 95% confidence interval: 1.22-4.63, P < 0.001) as the most severe form of peripheral vascular disease.
  
  
  CONCLUSIONS
  Diabetes is associated with an increased risk of mortality in peripheral vascular disease, and the effect is even more pronounced in patients with critical limb ischemia.
authors.affiliation: University of Zagreb, School of Medicine, Zagreb, Croatia.|Department of Vascular Medicine, Cardiovascular Center, Sisters of Charity University Hospital Center, Zagreb, Croatia.
authors.forename: Mislav
authors.initials: M
authors.lastname: Vrsalovic
authors.affiliation: Department of Nephrology, University Hospital Merkur, Zagreb, Croatia.
authors.forename: Ksenija
authors.initials: K
authors.lastname: Vucur
authors.affiliation: Faculty of Chemical Engineering and Technology, University of Zagreb, Zagreb, Croatia.
authors.forename: Ana
authors.initials: A
authors.lastname: Vrsalovic Presecki
authors.affiliation: Department of Cardiology, University Hospital Centre Split, School of Medicine, University of Split, Split, Croatia.
authors.forename: Damir
authors.initials: D
authors.lastname: Fabijanic
authors.affiliation: University of Zagreb, School of Medicine, Zagreb, Croatia.|Andrija Stampar School of Public Health, Zagreb, Croatia.
authors.forename: Milan
authors.initials: M
authors.lastname: Milosevic
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002423:Cause of Death; D016638:Critical Illness; D003920:Diabetes Mellitus / Q000401:mortality*; D005260:Female; D006801:Humans; D007511:Ischemia / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D058729:Peripheral Arterial Disease / Q000401:mortality*; D011379:Prognosis; D018570:Risk Assessment; D012307:Risk Factors
keywords: critical limb ischemia; diabetes; meta-analysis; mortality; peripheral artery disease