title: Palladium-Catalyzed, ortho-Selective C-H Halogenation of Benzyl Nitriles, Aryl Weinreb Amides, and Anilides.
abstract: A palladium-catalyzed, ortho-selective C-H halogenation methodology is reported herein. The highlight of the work is the highly selective C(sp2)-H functionalization of benzyl nitriles in the presence of activated C(sp3)-H bond, which results in good yields of the halogenated products with excellent regioselectivity. Along with benzyl nitriles, aryl Weinreb amides and anilides have been evaluated for the transformation using aprotic conditions. Mechanistic studies yield interesting aspects with respect to the pathway of the reaction and the directing group abilities.
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research (IISER) , Bhopal, Madhya Pradesh 462 066, India.
authors.forename: Riki
authors.initials: R
authors.lastname: Das
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research (IISER) , Bhopal, Madhya Pradesh 462 066, India.
authors.forename: Manmohan
authors.identifier: 0000-0003-2592-6726
authors.initials: M
authors.lastname: Kapur