title: Complete androgen insensitivity syndrome with concomitant seminoma and Sertoli cell adenoma: an unusual combination.
abstract: Androgen insensitivity syndrome is a rare disorder of sex development and its clinical manifestations vary from subtle male infertility to an overt complete androgen insensitivity syndrome (CAIS) with a female phenotype. CAIS is often diagnosed at puberty or in adolescence during investigation for primary amenorrhoea. Undiagnosed patients have an increased risk of development of malignancy in the harboured testes. Inguinal hernia is the commonest mode of presentation of CAIS in childhood and various screening methods are available during the initial herniorrhaphy procedure. Controversy exists in the need to screen and the methods of screening in all cases of premenstrual girls with inguinal hernia. Abnormal observation in a suspicious case requires karyotyping for confirmation. We describe a case of CAIS with simultaneous presence of seminoma and a Sertoli cell adenoma in a 17-year-old patient who had a history of surgery for inguinal hernia at age of 5 years.
authors.affiliation: Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Balamurugan
authors.initials: B
authors.lastname: Thirunavukkarasu
authors.affiliation: Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Asit Ranjan
authors.initials: AR
authors.lastname: Mridha
authors.affiliation: Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Neena
authors.initials: N
authors.lastname: Malhotra
authors.affiliation: Department of Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Sheragaru Hanumanthappa
authors.initials: SH
authors.lastname: Chandrashekhara
mesh_terms: D000236:Adenoma / Q000150:complications / Q000175:diagnosis*; D000293:Adolescent; D000568:Amenorrhea / Q000209:etiology; D013734:Androgen-Insensitivity Syndrome / Q000150:complications / Q000175:diagnosis*; D057210:Delayed Diagnosis; D005260:Female; D006552:Hernia, Inguinal / Q000150:complications; D006801:Humans; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000150:complications / Q000175:diagnosis*; D010386:Pelvic Neoplasms; D018239:Seminoma / Q000150:complications / Q000175:diagnosis*; D012707:Sertoli Cell Tumor / Q000150:complications / Q000175:diagnosis*; D013736:Testicular Neoplasms / Q000150:complications / Q000175:diagnosis*