title: Comparison of canaloplasty and trabeculectomy for open angle glaucoma: a Meta-analysis.
abstract: OBJECTIVE
  To evaluate the advantage of canaloplasty compared to trabeculectomy for patients with open angle glaucoma.
  
  
  METHODS
  Potentially relevant studies were systematically searched using various databases from inception until December 2015. The outcome analyses performed automatically using Revman 5.3 included intraocular pressure reduction (IOPR), postoperative success rate, anti-glaucoma medications reduction and the incidence of adverse events.
  
  
  RESULTS
  We included four qualified studies incorporating a total of 215 eyes for quantitative synthesis. The weighted mean difference (WMD) of IOPR between canaloplasty and trabeculectomy from baseline to 12mo was -2.33 (95%CI: -4.00, -0.66). There was not significant improvement in the complete or qualified success rate (OR: 0.58, 95%CI: 0.26, 1.31; OR: 0.50, 95%CI: 0.10, 2.44, respectively). Similarly, no statistically significance was observed in anti-glaucoma mediations reduction (WMD: -0.54, 95%CI: -1.18, 0.09). Sensitivity analysis of the primary outcome estimate confirmed the stability of the Meta-analysis result.
  
  
  CONCLUSIONS
  Trabeculectomy seems to be more effective in lowering IOP up to 12mo when comparing with canaloplasty. Canaloplasty does not seem to be inferior to trabeculectomy considering the postoperative success rate or the number of postoperative anti-glaucoma medications. Meanwhile, it has an advantage of less bleb related complications.
authors.affiliation: Department of Ophthalmology, Ruijin Hospital Affiliated Medical School, Shanghai Jiao Tong University, Shanghai 200025, China.
authors.forename: Zhong-Jing
authors.initials: ZJ
authors.lastname: Lin
authors.affiliation: Department of Ophthalmology, Ruijin Hospital Affiliated Medical School, Shanghai Jiao Tong University, Shanghai 200025, China.
authors.forename: Shuo
authors.initials: S
authors.lastname: Xu
authors.affiliation: Department of Ophthalmology, Ruijin Hospital Affiliated Medical School, Shanghai Jiao Tong University, Shanghai 200025, China.
authors.forename: Shou-Yue
authors.initials: SY
authors.lastname: Huang
authors.affiliation: Department of Ophthalmology, Hubei University of Science and Technology, Xianning 437100, Hubei Province, China.
authors.forename: Xiao-Bin
authors.initials: XB
authors.lastname: Zhang
authors.affiliation: Department of Ophthalmology, Ruijin Hospital Affiliated Medical School, Shanghai Jiao Tong University, Shanghai 200025, China.
authors.forename: Yi-Sheng
authors.initials: YS
authors.lastname: Zhong
keywords: Meta-analysis; canaloplasty; open angle glaucoma; trabeculectomy