title: Indexes of Insulin Resistance in Hyperinsulinemic Polycystic Ovary Syndrome in a Macedonian Cohort of Women of Reproductive Age: A Cross-Sectional Study.
abstract: BACKGROUND
  Polycystic ovary syndrome (PCOS) is complex hormonal, metabolic and reproductive disorder and is a leading cause of female infertility. Hyperinsulinemia secondary to insulin resistance plays important role in the pathogenesis of PCOS.
  
  
  OBJECTIVE
  To assess the sensitivity of different indices of insulin resistance and their relevance in a clinical setting.
  
  
  METHODS
  A cross-sectional study of 43 patients with PCOS and 29 noromo ovulatory women as a control group was conducted. Standard clinical, anthropometrical and hormonal testing for hyperandrogenism was conducted, as well as oral glucose tolerance test with determination of basal and stimulated glucose and insulin values.
  
  
  RESULTS
  The dynamic I/G index showed the highest sensitivity and specificity, but the static indexes HOMA-IR and QUICKI, although based on only basal glycemic and insulinemic values, showed good sensitivity, 90.38% and 94.01% respectively. HOMA-IR showed significant positive correlation with the stimulated insulin values.
  
  
  CONCLUSIONS
  Our results support the use of static indexes in the evaluation of insulin resistance in women with PCOS in a clinical setting, offering a simple assessment of insulin resistance in PCOS, which holds great prognostic and treatment implications.
authors.affiliation: University Clinic of Endocrinology, Diabetes and Metabolic Disorders, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.
authors.forename: Sasha
authors.initials: S
authors.lastname: Jovanovska-Mishevska
authors.affiliation: University Clinic of Gynecology and Obstetrics, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Atanasova-Boshku
authors.affiliation: University Clinic of Endocrinology, Diabetes and Metabolic Disorders, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.
authors.forename: Iskra
authors.initials: I
authors.lastname: Bitoska
authors.affiliation: University Clinic of Endocrinology, Diabetes and Metabolic Disorders, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.
authors.forename: Irfan
authors.initials: I
authors.lastname: Ahmeti
authors.affiliation: University Clinic of Endocrinology, Diabetes and Metabolic Disorders, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.
authors.forename: Biljana
authors.initials: B
authors.lastname: Todorova
authors.affiliation: University Clinic of Endocrinology, Diabetes and Metabolic Disorders, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.
authors.forename: Gordana
authors.initials: G
authors.lastname: Pemovska
authors.affiliation: University Clinic of Endocrinology, Diabetes and Metabolic Disorders, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.
authors.forename: Tatjana
authors.initials: T
authors.lastname: Milenkovic
authors.affiliation: University Clinic of Endocrinology, Diabetes and Metabolic Disorders, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.
authors.forename: Brankica
authors.initials: B
authors.lastname: Krstevska
keywords: HOMA-IR; QUICKI; hyperinsulinemia; insulin resistance; polycystic ovary syndrome