title: Investigation of the First Seven Reported Cases of Candida auris, a Globally Emerging Invasive, Multidrug-Resistant Fungus-United States, May 2013-August 2016.
abstract: November 11, 2016/65(44);1234-1237. What is already known about this topic? Candida auris is an emerging pathogenic fungus that has been reported from at least a dozen countries on four continents during 2009-2015. The organism is difficult to identify using traditional biochemical methods, some isolates have been found to be resistant to all three major classes of antifungal medications, and C. auris has caused health care-associated outbreaks. What is added by this report? This is the first description of C. auris cases in the United States. C. auris appears to have emerged in the United States only in the last few years, and U.S. isolates are related to isolates from South America and South Asia. Evidence from U.S. case investigations suggests likely transmission of the organism occurred in health care settings. What are the implications for public health practice? It is important that U.S. laboratories accurately identify C. auris and for health care facilities to implement recommended infection control practices to prevent the spread of C. auris. Local and state health departments and CDC should be notified of possible cases of C. auris and of isolates of C. haemulonii and Candida spp. that cannot be identified after routine testing.
authors.affiliation: Mycotic Diseases Branch, Division of Food Water and Environmental Diseases, CDC, Atlanta, GA.
authors.forename: S
authors.initials: S
authors.lastname: Vallabhaneni
authors.affiliation: Division of Healthcare Quality Promotion, CDC, Atlanta, GA.
authors.forename: A
authors.initials: A
authors.lastname: Kallen
authors.affiliation: Mycotic Diseases Branch, Division of Food Water and Environmental Diseases, CDC, Atlanta, GA.|Epidemic Intelligence Service, Center for Surveillance, Epidemiology and Laboratory Services, CDC, Atlanta, GA.
authors.forename: S
authors.initials: S
authors.lastname: Tsay
authors.affiliation: Mycotic Diseases Branch, Division of Food Water and Environmental Diseases, CDC, Atlanta, GA.
authors.forename: N
authors.initials: N
authors.lastname: Chow
authors.affiliation: Mycotic Diseases Branch, Division of Food Water and Environmental Diseases, CDC, Atlanta, GA.
authors.forename: R
authors.initials: R
authors.lastname: Welsh
authors.affiliation: Epidemic Intelligence Service, Center for Surveillance, Epidemiology and Laboratory Services, CDC, Atlanta, GA.|Chicago Department of Public Health, Chicago, IL.
authors.forename: J
authors.initials: J
authors.lastname: Kerins
authors.affiliation: Chicago Department of Public Health, Chicago, IL.
authors.forename: S K
authors.initials: SK
authors.lastname: Kemble
authors.affiliation: Chicago Department of Public Health, Chicago, IL.
authors.forename: M
authors.initials: M
authors.lastname: Pacilli
authors.affiliation: Chicago Department of Public Health, Chicago, IL.
authors.forename: S R
authors.initials: SR
authors.lastname: Black
authors.affiliation: University of Chicago, Chicago, IL.
authors.forename: E
authors.initials: E
authors.lastname: Landon
authors.affiliation: University of Chicago, Chicago, IL.
authors.forename: J
authors.initials: J
authors.lastname: Ridgway
authors.affiliation: National Institutes of Health Clinical Center, Bethesda, MD.
authors.forename: T N
authors.initials: TN
authors.lastname: Palmore
authors.affiliation: National Institutes of Health Clinical Center, Bethesda, MD.
authors.forename: A
authors.initials: A
authors.lastname: Zelzany
authors.affiliation: New York State Department of Health, New York, NY.
authors.forename: E H
authors.initials: EH
authors.lastname: Adams
authors.affiliation: New York State Department of Health, New York, NY.
authors.forename: M
authors.initials: M
authors.lastname: Quinn
authors.affiliation: New York State Department of Health, New York, NY.
authors.forename: S
authors.initials: S
authors.lastname: Chaturvedi
authors.affiliation: New York State Department of Health, New York, NY.
authors.forename: J
authors.initials: J
authors.lastname: Greenko
authors.affiliation: New York State Department of Health, New York, NY.
authors.forename: R
authors.initials: R
authors.lastname: Fernandez
authors.affiliation: New York State Department of Health, New York, NY.
authors.forename: K
authors.initials: K
authors.lastname: Southwick
authors.affiliation: Columbia University College of Physicians & Surgeons, New York, NY.
authors.forename: E Y
authors.initials: EY
authors.lastname: Furuya
authors.affiliation: Weill Cornell Medicine, New York, NY.
authors.forename: D P
authors.initials: DP
authors.lastname: Calfee
authors.affiliation: Mount Sinai Health System/Icahn School of Medicine at Mount Sinai, New York, NY.
authors.forename: C
authors.initials: C
authors.lastname: Hamula
authors.affiliation: Mount Sinai Health System/Icahn School of Medicine at Mount Sinai, New York, NY.
authors.forename: G
authors.initials: G
authors.lastname: Patel
authors.affiliation: New Jersey Department of Health, Trenton, NJ.
authors.forename: P
authors.initials: P
authors.lastname: Barrett
authors.affiliation: Robert Wood Johnson University Hospital, New Brunswick, NJ.
authors.forename: P
authors.initials: P
authors.lastname: Lafaro
authors.affiliation: Mycotic Diseases Branch, Division of Food Water and Environmental Diseases, CDC, Atlanta, GA.
authors.forename: E L
authors.initials: EL
authors.lastname: Berkow
authors.affiliation: Division of Healthcare Quality Promotion, CDC, Atlanta, GA.
authors.forename: H
authors.initials: H
authors.lastname: Moulton-Meissner
authors.affiliation: Division of Healthcare Quality Promotion, CDC, Atlanta, GA.
authors.forename: J
authors.initials: J
authors.lastname: Noble-Wang
authors.affiliation: Division of Healthcare Quality Promotion, CDC, Atlanta, GA.
authors.forename: R P
authors.initials: RP
authors.lastname: Fagan
authors.affiliation: Mycotic Diseases Branch, Division of Food Water and Environmental Diseases, CDC, Atlanta, GA.
authors.forename: B R
authors.initials: BR
authors.lastname: Jackson
authors.affiliation: Mycotic Diseases Branch, Division of Food Water and Environmental Diseases, CDC, Atlanta, GA.
authors.forename: S R
authors.initials: SR
authors.lastname: Lockhart
authors.affiliation: Mycotic Diseases Branch, Division of Food Water and Environmental Diseases, CDC, Atlanta, GA.
authors.forename: A P
authors.initials: AP
authors.lastname: Litvintseva
authors.affiliation: Mycotic Diseases Branch, Division of Food Water and Environmental Diseases, CDC, Atlanta, GA.
authors.forename: T M
authors.initials: TM
authors.lastname: Chiller
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D002175:Candida / Q000187:drug effects / Q000302:isolation & purification*; D002177:Candidiasis / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology*; D021821:Communicable Diseases, Emerging; D026141:Drug Resistance, Multiple, Fungal; D014943:Global Health; D006801:Humans; D011379:Prognosis; D012307:Risk Factors; D013997:Time Factors; D014481:United States
chemical_list: D000935:Antifungal Agents