title: Total Synthesis of the Labdane Diterpenes Galanal A and B from Geraniol.
abstract: The first total synthesis of galanal A and B has been achieved from naturally occurring geraniol. Key steps in this synthesis are the use of a Lewis acid assisted chiral Brønsted acid (chiral LBA) mediated cationic polyene cyclization and a titanocene-mediated radical cyclization for the asymmetric assembly of the "AB" ring and the construction of the all-carbon quaternary center at the junction of the "BC" ring, respectively.
authors.affiliation: Department of Chemistry, National Taiwan University , Taipei 106, Taiwan.
authors.forename: Shih-Che
authors.initials: SC
authors.lastname: Lin
authors.forename: Rong-Jie
authors.identifier: 0000-0002-0119-8288
authors.initials: RJ
authors.lastname: Chein
mesh_terms: D000080462:Acyclic Monoterpenes; D004224:Diterpenes / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism; D013729:Terpenes / Q000737:chemistry*
chemical_list: D000080462:Acyclic Monoterpenes; D004224:Diterpenes; D013729:Terpenes; C476264:galanal A; C476265:galanal B; C007836:geraniol