title: Complete genome sequence of the actinomyceteActinoalloteichus hymeniacidonistype strain HPA 177Tisolated from a marine sponge.
abstract: Actinoalloteichus hymeniacidonisHPA 177Tis a Gram-positive, strictly aerobic, black pigment producing and spore-forming actinomycete, which forms branching vegetative hyphae and was isolated from the marine spongeHymeniacidon perlevis. Actinomycete bacteria are prolific producers of secondary metabolites, some of which have been developed into anti-microbial, anti-tumor and immunosuppressive drugs currently used in human therapy. Considering this and the growing interest in natural products as sources of new drugs, actinomycete bacteria from the hitherto poorly explored marine environments may represent promising sources for drug discovery. AsA. hymeniacidonis, isolated from the marine sponge, is a type strain of the recently described and rare genusActinoalloteichus, knowledge of the complete genome sequence enables genome analyses to identify genetic loci for novel bioactive compounds. This project, describing the 6.31 Mbp long chromosome, with its 5346 protein-coding and 73 RNA genes, will aid theGenomic Encyclopedia of Bacteria and Archaeaproject.
authors.affiliation: Technology Platform Genomics, CeBiTec, Bielefeld University, Bielefeld, Germany.
authors.forename: Lena
authors.initials: L
authors.lastname: Schaffert
authors.affiliation: Technology Platform Genomics, CeBiTec, Bielefeld University, Bielefeld, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Albersmeier
authors.affiliation: Technology Platform Genomics, CeBiTec, Bielefeld University, Bielefeld, Germany.
authors.forename: Anika
authors.initials: A
authors.lastname: Winkler
authors.affiliation: Technology Platform Genomics, CeBiTec, Bielefeld University, Bielefeld, Germany.
authors.forename: Jörn
authors.initials: J
authors.lastname: Kalinowski
authors.affiliation: Department of Pharmacognosy, University of Vienna, 1090 Vienna, Austria.
authors.forename: Sergey B
authors.initials: SB
authors.lastname: Zotchev
authors.affiliation: Technology Platform Genomics, CeBiTec, Bielefeld University, Bielefeld, Germany ; Sinkey Lab, Department of Biology, Massachusetts Institute of Technology, Cambridge, USA.
authors.forename: Christian
authors.identifier: 0000-0002-9722-4435
authors.initials: C
authors.lastname: Rückert
keywords: Actinoalloteichus; Branching vegetative hyphae; Gram-positive; Non-acid-fast; Non-motile; Secondary metabolite biosynthesis gene clusters; Spore forming; Strictly aerobic