title: NFAT1 promotes cell motility through MMP-3 in esophageal squamous cell carcinoma.
abstract: Esophageal squamous cell carcinoma (ESCC) is one of the most common malignant tumors and the prognosis of patients remains poor. Increasing evidence suggests that nuclear factor of activated T cell (NFAT1) plays an important role in the development and progression of cancers. Herein, we show that NFAT1 was overexpressed in human ESCC, which was significantly associated with advanced tumor stage and lymph node metastasis. Functional studies found that NFAT1 silencing could suppress cell migration and invasion through MMP-3. The data therefore suggest that NFAT1 plays an important adverse role in the development and progression of ESCC, implicating possible application in clinics as a biomarker and a potential new therapeutic target.
authors.affiliation: Department of Thoracic Surgery, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, Henan, China; The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, Henan, China.
authors.forename: Peinan
authors.initials: P
authors.lastname: Chen
authors.affiliation: Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, Henan, China.
authors.forename: Zhengzheng
authors.initials: Z
authors.lastname: Shan
authors.affiliation: Department of Gastroenterology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, Henan, China.
authors.forename: Jianbo
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Thoracic Surgery, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, Henan, China.
authors.forename: Fengke
authors.initials: F
authors.lastname: Li
authors.affiliation: Department of Thoracic Surgery, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, Henan, China.
authors.forename: Wenqiang
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Thoracic Surgery, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, Henan, China.
authors.forename: Liankai
authors.initials: L
authors.lastname: Yang
authors.affiliation: Department of Thoracic Surgery, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, Henan, China. Electronic address: chest@163.com.
authors.forename: Zhuangshi
authors.initials: Z
authors.lastname: Huang
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics*; D018450:Disease Progression; D004938:Esophageal Neoplasms / Q000235:genetics* / Q000473:pathology; D000077277:Esophageal Squamous Cell Carcinoma; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D006801:Humans; D008207:Lymphatic Metastasis / Q000235:genetics / Q000473:pathology; D008297:Male; D019278:Matrix Metalloproteinase 3 / Q000235:genetics*; D008875:Middle Aged; D050778:NFATC Transcription Factors / Q000235:genetics*; D009363:Neoplasm Proteins / Q000235:genetics; D011379:Prognosis
chemical_list: D050778:NFATC Transcription Factors; C494006:NFATC2 protein, human; D009363:Neoplasm Proteins; C511768:MMP3 protein, human; D019278:Matrix Metalloproteinase 3
keywords: Esophageal squamous cell carcinoma (ESCC); MMP-3; Nuclear factor of activated t cell (NFAT1)