title: Distinctive Structural and Effective Connectivity Changes of Semantic Cognition Network across Left and Right Mesial Temporal Lobe Epilepsy Patients.
abstract: Occurrence of language impairment in mesial temporal lobe epilepsy (mTLE) patients is common and left mTLE patients always exhibit a primary problem with access to names. To explore different neuropsychological profiles between left and right mTLE patients, the study investigated both structural and effective functional connectivity changes within the semantic cognition network between these two groups and those from normal controls. We found that gray matter atrophy of left mTLE patients was more severe than that of right mTLE patients in the whole brain and especially within the semantic cognition network in their contralateral hemisphere. It suggested that seizure attacks were rather targeted than random for patients with hippocampal sclerosis (HS) in the dominant hemisphere. Functional connectivity analysis during resting state fMRI revealed that subregions of the anterior temporal lobe (ATL) in the left HS patients were no longer effectively connected. Further, we found that, unlike in right HS patients, increased causal linking between ipsilateral regions in the left HS epilepsy patients cannot make up for their decreased contralateral interaction. It suggested that weakened contralateral connection and disrupted effective interaction between subregions of the unitary, transmodal hub of the ATL may be the primary cause of anomia in the left HS patients.
authors.affiliation: Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
authors.forename: Xiaotong
authors.initials: X
authors.lastname: Fan
authors.affiliation: Departments of Psychology and Linguistics, Xidian University, Xi'an 710126, China; Neuroimaging Laboratory, School of Biomedical Engineering, Shenzhen University Health Science Center, Shenzhen 518060, China.
authors.forename: Hao
authors.identifier: 0000-0002-1854-786X
authors.initials: H
authors.lastname: Yan
authors.affiliation: Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
authors.forename: Yi
authors.identifier: 0000-0003-2646-8835
authors.initials: Y
authors.lastname: Shan
authors.affiliation: Department of Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
authors.forename: Kun
authors.initials: K
authors.lastname: Shang
authors.affiliation: Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.
authors.forename: Xiaocui
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
authors.forename: Peipei
authors.initials: P
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
authors.forename: Yongzhi
authors.initials: Y
authors.lastname: Shan
authors.affiliation: Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China; Department of Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing 100053, China; Center of Stroke, Beijing Institute for Brain Disorder, Beijing 100069, China; Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing 100053, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Lu
authors.affiliation: Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China; Center of Epilepsy, Beijing Institute for Brain Disorder, Beijing 100069, China.
authors.forename: Guoguang
authors.identifier: 0000-0002-7569-5252
authors.initials: G
authors.lastname: Zhao
mesh_terms: D000293:Adolescent; D000328:Adult; D003071:Cognition / Q000502:physiology*; D004833:Epilepsy, Temporal Lobe / Q000000981:diagnostic imaging* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000000981:diagnostic imaging* / Q000503:physiopathology; D009434:Neural Pathways / Q000000981:diagnostic imaging / Q000503:physiopathology; D012660:Semantics; D055815:Young Adult