title: CORRELATION BETWEEN CYSTOID SPACES IN CHRONIC DIABETIC MACULAR EDEMA AND CAPILLARY NONPERFUSION DETECTED BY OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY.
abstract: OBJECTIVE
  To study the relationship between the location of cystoid spaces and retinal capillary nonperfusion areas in diabetic cystoid macular edema (DCME).
  
  
  METHODS
  In this retrospective study, 24 eyes of 21 patients with chronic DCME were followed using optical coherence tomography angiography. The capillary density of the superficial capillary plexus and deep capillary plexus was measured using AngioAnalytics software in all DCME eyes and in 20 healthy controls. Diabetic cystoid macular edema improved spontaneously or after treatment in 11 eyes.
  
  
  RESULTS
  The intraretinal cystoid spaces were surrounded by capillary-flow void areas in the superficial capillary plexus in 71% of cases and in the deep capillary plexus in 96% of cases. The deep capillary plexus had lost its regular pattern in all cases. The capillary density was decreased in both plexus (mean decrease of -23.0% in the superficial capillary plexus and -12.4% in the deep capillary plexus vs. normal). In the 11 cases with DCME resolution, the capillary did not reperfuse in areas of resolved cystoid spaces, and the capillary density did not change significantly.
  
  
  CONCLUSIONS
  In chronic DCME, cystoid spaces were located within capillary dropout areas. No reperfusion occurred after DCME resolution. The impact of the severity of this nonperfusion on the risk of recurrence of DCME remains to be clarified.
authors.affiliation: Department of Ophthalmology, Hôpital Lariboisière, AP-HP, Université Paris 7-Sorbonne Paris Cité, Paris, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Mané
authors.forename: Bénédicte
authors.initials: B
authors.lastname: Dupas
authors.forename: Alain
authors.initials: A
authors.lastname: Gaudric
authors.forename: Sophie
authors.initials: S
authors.lastname: Bonnin
authors.forename: Alexandre
authors.initials: A
authors.lastname: Pedinielli
authors.forename: Elodie
authors.initials: E
authors.lastname: Bousquet
authors.forename: Ali
authors.initials: A
authors.lastname: Erginay
authors.forename: Ramin
authors.initials: R
authors.lastname: Tadayoni
authors.forename: Aude
authors.initials: A
authors.lastname: Couturier
mesh_terms: D000328:Adult; D000368:Aged; D002196:Capillaries / Q000000981:diagnostic imaging / Q000473:pathology*; D016022:Case-Control Studies; D000072226:Computed Tomography Angiography / Q000379:methods; D003922:Diabetes Mellitus, Type 1 / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology*; D003924:Diabetes Mellitus, Type 2 / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology*; D003930:Diabetic Retinopathy / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D006801:Humans; D058449:Intravitreal Injections; D008269:Macular Edema / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012171:Retinal Vessels / Q000000981:diagnostic imaging / Q000473:pathology*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors
chemical_list: D042461:Vascular Endothelial Growth Factor A