title: Syndrome of inappropriate antidiuretic hormone secretion in a case of olfactory neuroblastoma without anti-diuretic hormone immunoreactivity: A case report and review of the literature.
abstract: Olfactory neuroblastoma (ONB) is a relatively rare nasal or paranasal malignant tumor. This tumor is rarely accompanied by paraneoplastic syndromes such as syndrome of inappropriate antidiuretic hormone secretion (SIADH). Here, we report a 31-year-old female with histologically confirmed ONB who had been diagnosed with SIADH three years prior. She was treated with surgery followed by concurrent chemoradiotherapy. SIADH resolved immediately after surgical tumor resection. Immunohistochemically, both biopsy and resected specimens from the nasal cavity had been negative for ADH. Although extremely rare, ONB may be associated with SIADH, and the possibility of this cancer should be taken into account during the follow-up of idiopathic SIADH.
authors.affiliation: Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-3-1, Higashi-ku, Fukuoka 812-8582, Japan; Department of Otolaryngology, Hamanomachi Hospital, Nagahama 3-3-1, Chuo-ku, Fukuoka 810-8539, Japan. Electronic address: tn01061@surgpath.med.kyushu-u.ac.jp.
authors.forename: Takafumi
authors.initials: T
authors.lastname: Nakano
authors.affiliation: Department of Pathology, Hamanomachi Hospital, Nagahama 3-3-1, Chuo-ku, Fukuoka 810-8539, Japan.
authors.forename: Junichi
authors.initials: J
authors.lastname: Motoshita
authors.affiliation: Department of Endocrine and Metabolic Diseases/Diabetes Mellitus, Hamanomachi Hospital, Nagahama 3-3-1, Chuo-ku, Fukuoka 810-8539, Japan.
authors.forename: Fumi
authors.initials: F
authors.lastname: Sawada
authors.affiliation: Department of Otolaryngology, Hamanomachi Hospital, Nagahama 3-3-1, Chuo-ku, Fukuoka 810-8539, Japan.
authors.forename: Midori
authors.initials: M
authors.lastname: Okabe
authors.affiliation: Department of Otolaryngology, Hamanomachi Hospital, Nagahama 3-3-1, Chuo-ku, Fukuoka 810-8539, Japan.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Tamae
authors.affiliation: Department of Endocrine and Metabolic Diseases/Diabetes Mellitus, Hamanomachi Hospital, Nagahama 3-3-1, Chuo-ku, Fukuoka 810-8539, Japan.
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Hiramatsu
authors.affiliation: Department of Otolaryngology, Graduate School of Medical Sciences, Oita University, Idaigaoka 1-1, Hazama-machi, Oita 879-5593, Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Kodama
authors.affiliation: Department of Otolaryngology, Hamanomachi Hospital, Nagahama 3-3-1, Chuo-ku, Fukuoka 810-8539, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Shiratsuchi
authors.affiliation: Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-3-1, Higashi-ku, Fukuoka 812-8582, Japan.
authors.forename: Ryuji
authors.initials: R
authors.lastname: Yasumatsu
authors.affiliation: Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-3-1, Higashi-ku, Fukuoka 812-8582, Japan.
authors.forename: Torahiko
authors.initials: T
authors.lastname: Nakashima
authors.affiliation: Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-3-1, Higashi-ku, Fukuoka 812-8582, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakagawa
mesh_terms: D000328:Adult; D019002:CD56 Antigen / Q000378:metabolism; D059248:Chemoradiotherapy; D053379:Chromogranin A / Q000378:metabolism; D018304:Esthesioneuroblastoma, Olfactory / Q000150:complications / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D007177:Inappropriate ADH Syndrome / Q000175:diagnosis* / Q000209:etiology; D009296:Nasal Cavity; D009669:Nose Neoplasms / Q000150:complications / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology; D013517:Otorhinolaryngologic Surgical Procedures; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D000072078:Positron Emission Tomography Computed Tomography; D016708:Synaptophysin / Q000378:metabolism; D014057:Tomography, X-Ray Computed
chemical_list: D019002:CD56 Antigen; D053379:Chromogranin A; C522918:NCAM1 protein, human; D016708:Synaptophysin; D010751:Phosphopyruvate Hydratase
keywords: Anti-diuretic hormone; Olfactory neuroblastoma; Syndrome of inappropriate antidiuretic hormone secretion