title: Knock out of the NADPH oxidase Nox4 has no impact on life span in mice.
abstract: The free radical theory of aging suggests reactive oxygen species as a main reason for accumulation of damage events eventually leading to aging. Nox4, a member of the family of NADPH oxidases constitutively produces ROS and therefore has the potential to be a main driver of aging. Herein we analyzed the life span of Nox4 deficient mice and found no difference when compared to their wildtype littermates. Accordingly neither Tert expression nor telomere length was different in cells isolated from those animals. In fact, Nox4 mRNA expression in lungs of wildtype mice dropped with age. We conclude that Nox4 has no influence on lifespan of healthy mice.
authors.affiliation: Institute for Cardiovascular Physiology, Goethe-University, Frankfurt, Germany.
authors.forename: Flavia
authors.initials: F
authors.lastname: Rezende
authors.affiliation: Institute for Cardiovascular Physiology, Goethe-University, Frankfurt, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Schürmann
authors.affiliation: Institute for Cardiovascular Physiology, Goethe-University, Frankfurt, Germany.
authors.forename: Susanne
authors.initials: S
authors.lastname: Schütz
authors.affiliation: Institute for Cardiovascular Physiology, Goethe-University, Frankfurt, Germany.
authors.forename: Sabine
authors.initials: S
authors.lastname: Harenkamp
authors.affiliation: Instituts für Biostatistik und Mathematische Modellierung, Goethe-University, Frankfurt, Germany.
authors.forename: Eva
authors.initials: E
authors.lastname: Herrmann
authors.affiliation: Justus-Liebig University, Giessen, German Center for Lung Research (DZL), Germany; Excellence Cluster Cardiovascular and Pulmonary System (ECCPS), Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Seimetz
authors.affiliation: Justus-Liebig University, Giessen, German Center for Lung Research (DZL), Germany; Excellence Cluster Cardiovascular and Pulmonary System (ECCPS), Germany.
authors.forename: Norbert
authors.initials: N
authors.lastname: Weißmann
authors.affiliation: Institute for Cardiovascular Physiology, Goethe-University, Frankfurt, Germany; Excellence Cluster Cardiovascular and Pulmonary System (ECCPS), Germany; German Center for Cardiovascular Research (DZHK), Partner site RheinMain, Frankfurt, Germany. Electronic address: Schroeder@vrc.uni-frankfurt.de.
authors.forename: Katrin
authors.initials: K
authors.lastname: Schröder
mesh_terms: D000818:Animals; D004847:Epithelial Cells / Q000166:cytology / Q000378:metabolism*; D005260:Female; D015870:Gene Expression; D008136:Longevity / Q000235:genetics; D008168:Lung / Q000166:cytology / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D000074663:NADPH Oxidase 4 / Q000172:deficiency* / Q000235:genetics; D061251:Primary Cell Culture; D019098:Telomerase / Q000235:genetics* / Q000378:metabolism; D059505:Telomere Homeostasis
chemical_list: D000074663:NADPH Oxidase 4; C422943:Nox4 protein, mouse; D019098:Telomerase; C509187:Tert protein, mouse
keywords: Aging; Nox4