title: Adjustment of Eculizumab Dosage Pattern in Patients with Atypical Hemolytic Uremic Syndrome with Suboptimal Response to Standard Treatment Pattern.
abstract: In patients with atypical hemolytic uremic syndrome (aHUS), complement blocking by eculizumab rapidly halts the process of thrombotic microangiopathy and it is associated with clear long-term hematologic and renal improvements. Eculizumab treatment consists of a 4-week initial phase with weekly IV administration of 900 mg doses, followed by a maintenance phase with a 1,200 mg dose in the fifth week and every 14 ± 2 days thereafter. We present three patients with aHUS and suboptimal response to eculizumab treatment at the usual administration dosage who showed hematologic and renal improvements after an adjustment in the eculizumab treatment protocol.
authors.affiliation: Nephrology Service, Hospital San Agustín, Camino de Heros 6, 33401 Avilés, Spain.
authors.forename: Camino
authors.identifier: 0000-0002-7393-6331
authors.initials: C
authors.lastname: García Monteavaro
authors.affiliation: Nephrology Service, Hospital Universitari Joan XXIII, C/Dr. Mallafrè Guasch 4, 43005 Tarragona, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Peralta Roselló
authors.affiliation: Nephrology Service, Hospital Universitario de Guadalajara, C/Donante de Sangre s/n, 19002 Guadalajara, Spain; Nephrology Service, Hospitales Madrid, Pl. del Conde del Valle de Súchil 16, 28015 Madrid, Spain.
authors.forename: Borja
authors.identifier: 0000-0001-5730-1929
authors.initials: B
authors.lastname: Quiroga
authors.affiliation: Nephrology Service, Hospital San Agustín, Camino de Heros 6, 33401 Avilés, Spain.
authors.forename: José María
authors.initials: JM
authors.lastname: Baltar Martín
authors.affiliation: Nephrology Service, Hospital Universitari Joan XXIII, C/Dr. Mallafrè Guasch 4, 43005 Tarragona, Spain.
authors.forename: Lorena
authors.initials: L
authors.lastname: Castillo Eraso
authors.affiliation: Nephrology Service, Hospitales Madrid, Pl. del Conde del Valle de Súchil 16, 28015 Madrid, Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: de Álvaro Moreno
authors.affiliation: Nephrology Service, Hospital Universitari Joan XXIII, C/Dr. Mallafrè Guasch 4, 43005 Tarragona, Spain.
authors.forename: Alberto
authors.initials: A
authors.lastname: Martínez Vea
authors.affiliation: Nephrology Service, Hospital San Agustín, Camino de Heros 6, 33401 Avilés, Spain.
authors.forename: María Teresa
authors.initials: MT
authors.lastname: Visus-Fernández de Manzanos