title: Biocompatibility of sol-gel hydroxyapatite-titania composite and bilayer coatings.
abstract: Titania-Hydroxyapatite (TiO2/HAP) reinforced coatings are proposed to enhance the bioactivity and corrosion resistance of 316L stainless steel (316L SS). Herein, spin- and dip-coating sol-gel processes were investigated to construct two kinds of coatings: TiO2/HAP composite and TiO2/HAP bilayer. Physicochemical characterization highlighted the bioactivity response of the TiO2/HAP composite once incubated in physiological conditions for 7days whereas the TiO2/HAP bilayer showed instability and dissolution. Biological analysis revealed a failure in human stem cells adhesion on TiO2/HAP bilayer whereas on TiO2/HAP composite the presence of polygonal shaped cells, possessing good behaviour attested a good biocompatibility of the composite coating. Finally, TiO2/HAP composite with hardness up to 0.6GPa and elastic modulus up to 18GPa, showed an increased corrosion resistance of 316L SS. In conclusion, the user-friendly sol-gel processes led to bioactive TiO2/HAP composite buildup suitable for biomedical applications.
authors.affiliation: Laboratoire de Génie de l'Environnement (LGE), Faculté de Technologie, Université de Bejaia, 06000, Bejaia, Alegria. Electronic address: dj.sidane@yahoo.fr.
authors.forename: D
authors.initials: D
authors.lastname: Sidane
authors.affiliation: Equipe d'Accueil 4691 Biomatériaux et Inflammation en Site Osseux, SFR-CAP Santé (FED 4231), Université de Reims Champagne Ardenne, 1 Avenue du Maréchal Juin, 51100 Reims, France.
authors.forename: H
authors.initials: H
authors.lastname: Rammal
authors.affiliation: UMR CNRS 7369, Equipe MéDIAN Biophotonique et Technologies pour la Santé, UFR de Pharmacie, SFR-CAP Santé (FED 4231), Université de Reims Champagne Ardenne, 51 rue Cognacq-Jay, 51096 Reims, France.
authors.forename: A
authors.initials: A
authors.lastname: Beljebbar
authors.affiliation: Equipe d'Accueil 4691 Biomatériaux et Inflammation en Site Osseux, SFR-CAP Santé (FED 4231), Université de Reims Champagne Ardenne, 1 Avenue du Maréchal Juin, 51100 Reims, France.
authors.forename: S C
authors.initials: SC
authors.lastname: Gangloff
authors.affiliation: FRE 3723 - LML - Laboratoire de Mécanique de Lille, Univ. Lille, 59000 Lille, France.
authors.forename: D
authors.initials: D
authors.lastname: Chicot
authors.affiliation: Equipe d'Accueil 4691 Biomatériaux et Inflammation en Site Osseux, SFR-CAP Santé (FED 4231), Université de Reims Champagne Ardenne, 1 Avenue du Maréchal Juin, 51100 Reims, France.
authors.forename: F
authors.initials: F
authors.lastname: Velard
authors.affiliation: Laboratoire de Génie de l'Environnement (LGE), Faculté de Technologie, Université de Bejaia, 06000, Bejaia, Alegria.
authors.forename: H
authors.initials: H
authors.lastname: Khireddine
authors.affiliation: MSMP, Arts et Métiers Paris Tech, 8, Boulevard Louis XIV, 59046 Lille Cedex, France.
authors.forename: A
authors.initials: A
authors.lastname: Montagne
authors.affiliation: Equipe d'Accueil 4691 Biomatériaux et Inflammation en Site Osseux, SFR-CAP Santé (FED 4231), Université de Reims Champagne Ardenne, 1 Avenue du Maréchal Juin, 51100 Reims, France.
authors.forename: H
authors.initials: H
authors.lastname: Kerdjoudj
mesh_terms: D002448:Cell Adhesion / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D020099:Coated Materials, Biocompatible / Q000737:chemistry* / Q000494:pharmacology; D003343:Corrosion; D003599:Cytoskeleton / Q000187:drug effects; D017886:Durapatite / Q000737:chemistry*; D055664:Electrochemical Techniques; D005782:Gels / Q000737:chemistry; D006244:Hardness; D006801:Humans; D008855:Microscopy, Electron, Scanning; D013052:Spectrometry, X-Ray Emission; D013193:Stainless Steel / Q000737:chemistry; D013234:Stem Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D014025:Titanium / Q000737:chemistry*; D014470:Umbilical Cord / Q000166:cytology; D014961:X-Ray Diffraction
chemical_list: D020099:Coated Materials, Biocompatible; D005782:Gels; D013193:Stainless Steel; C009495:titanium dioxide; D017886:Durapatite; D014025:Titanium
keywords: Biocompatibility; Hydroxyapatite; Stainless steel 316L; Stem cells; Surface coating; Titania