title: 18F-FDG and 68Ga-DOTATATE PET/CT in von Hippel-Lindau Disease-Associated Retinal Hemangioblastoma.
abstract: Retinal hemangioblastomas are highly vascular benign tumors that can be encountered either sporadically or within the von Hippel-Lindau (VHL) syndrome. We report a case of a VHL patient with retinal hemangioblastoma who underwent PET/CT scans using F-FDG and Ga-DOTATATE. The tumor showed low-level F-FDG and increased Ga-DOTATATE activity, suggesting cell-surface overexpression of somatostatin receptors. The presented case indicates the clinical applications of somatostatin receptor imaging with Ga-DOTA-conjugated peptides in detection and follow-up of VHL manifestations, screening of asymptomatic gene carriers, and in diagnosis of sporadic retinal hemangioblastomas, which may have similar features on MRI with other retinal tumors.
authors.affiliation: From the *Radiology and Imaging Sciences, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda; †PET-Department, Clinical Center, National Institutes of Health, Bethesda, MD; ‡Leeds Medical School, Leeds, UK; §Center for Research in Computer Vision, Electrical and Computer Science Department, University of Central Florida (UCF), Orlando, FL; ∥Endocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD; ¶Endocrine and Thoracic Surgery, University Hospitals of Geneva, Geneva, Switzerland; and **Department of Radiology, Medical School, University of Crete, Crete, Greece.
authors.forename: Georgios Z
authors.initials: GZ
authors.lastname: Papadakis
authors.forename: Corina
authors.initials: C
authors.lastname: Millo
authors.forename: Inderbir S
authors.initials: IS
authors.lastname: Jassel
authors.forename: Ulas
authors.initials: U
authors.lastname: Bagci
authors.forename: Samira M
authors.initials: SM
authors.lastname: Sadowski
authors.forename: Apostolos H
authors.initials: AH
authors.lastname: Karantanas
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Patronas
mesh_terms: D000328:Adult; D019788:Fluorodeoxyglucose F18; D005710:Gallium Radioisotopes; D018325:Hemangioblastoma / Q000000981:diagnostic imaging* / Q000378:metabolism; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009942:Organometallic Compounds; D000072078:Positron Emission Tomography Computed Tomography; D019275:Radiopharmaceuticals; D017481:Receptors, Somatostatin / Q000378:metabolism; D019572:Retinal Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism; D006623:von Hippel-Lindau Disease / Q000000981:diagnostic imaging* / Q000235:genetics / Q000378:metabolism
chemical_list: D005710:Gallium Radioisotopes; D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; D017481:Receptors, Somatostatin; D019788:Fluorodeoxyglucose F18; C513399:gallium Ga 68 dotatate