title: Novel application for electrochemotherapy: Immersion of nasal cavity in dog.
abstract: Electrochemotherapy is a new modality of local cancer treatment that increases the delivery of chemotherapy drugs into tumor cells by applying intense electric fields. This novel electrochemotherapy application was applied as an adjuvant to surgery and eliminated intranasal tumors in dog. The treatment challenges are the surgery limitations due to anatomy and residual tumor in the bone cavity. Most of the tumoral mass on nasal cavity was surgically removed. The internal nasal cavity was immersed in liquid and bleomycin before applying electric field. The solution was necessary to increase the superficial contact between plate electrodes and residual tumor. The numerical study demonstrated electrochemotherapy efficiency in different clinical situations. The proximity between electrodes and bone (<3 mm) and bone irregularities affect the electric field distribution on tumoral tissue. The tumoral tissue around bone protuberances tends to be eliminated. Electrochemotherapy with plate electrodes inside the cavity might not be effective. Different values of electric conductivity solution were studied; the ideal value was 0.5 S/m. The numerical and experimental results confirm the successful application of electrochemotherapy on dog nasal cavity.
authors.affiliation: Institute of Biomedical Engineering, Federal University of Santa Catarina (UFSC), Florianópolis-SC.
authors.forename: Daniela O H
authors.initials: DOH
authors.lastname: Suzuki
authors.affiliation: Institute of Biomedical Engineering, Federal University of Santa Catarina (UFSC), Florianópolis-SC.
authors.forename: José A
authors.initials: JA
authors.lastname: Berkenbrock
authors.affiliation: Oncology Veterinary, VetCâncer, São Paulo-SP, Brazil.
authors.forename: Krishna D
authors.initials: KD
authors.lastname: de Oliveira
authors.affiliation: Oncology Veterinary, VetCâncer, São Paulo-SP, Brazil.
authors.forename: Jennifer O
authors.initials: JO
authors.lastname: Freytag
authors.affiliation: Oncology Veterinary, VetCâncer, São Paulo-SP, Brazil.
authors.forename: Marcelo M M
authors.initials: MMM
authors.lastname: Rangel
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000627:therapeutic use; D001761:Bleomycin / Q000008:administration & dosage* / Q000627:therapeutic use; D003198:Computer Simulation; D004283:Dog Diseases / Q000188:drug therapy* / Q000473:pathology; D004285:Dogs; D004553:Electric Conductivity; D053672:Electrochemotherapy / Q000379:methods*; D020342:Finite Element Analysis; D008954:Models, Biological; D009296:Nasal Cavity / Q000187:drug effects* / Q000473:pathology; D009669:Nose Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000662:veterinary*
chemical_list: D000903:Antibiotics, Antineoplastic; D001761:Bleomycin
keywords: Electric conductivity; Electric field; Electrochemotherapy; Nasal tumor; Transmissible venereal tumor