title: A new androstanoid metabolite from a soil fungus Curvularia borreriae strain HS-FG-237.
abstract: A new androstanoid metabolite, 4α-methyl-9α-methoxyandrosta-8,15-diene-3,17-dione (1), was isolated from a soil fungus Curvularia borreriae (Pleosporaceae) strain HS-FG-237. Its structure was determined by extensive spectroscopic and X-ray diffraction analyses. Compound 1 exhibited poor cytotoxicity toward HCT-116 cells by CCK-8 assay and weak anti-inflammatory activity in an ANA-1 murine macrophages model.
authors.affiliation: a School of Pharmaceutical Sciences , Central South University , Changsha , China.|b Department of New Drug Screening , Zhejiang Hisun Pharmaceutical Co., Ltd. , Taizhou , China.
authors.forename: Li-Fei
authors.initials: LF
authors.lastname: Liu
authors.affiliation: b Department of New Drug Screening , Zhejiang Hisun Pharmaceutical Co., Ltd. , Taizhou , China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.affiliation: b Department of New Drug Screening , Zhejiang Hisun Pharmaceutical Co., Ltd. , Taizhou , China.
authors.forename: Huan
authors.initials: H
authors.lastname: Qi
authors.affiliation: b Department of New Drug Screening , Zhejiang Hisun Pharmaceutical Co., Ltd. , Taizhou , China.
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Wang
authors.affiliation: b Department of New Drug Screening , Zhejiang Hisun Pharmaceutical Co., Ltd. , Taizhou , China.
authors.forename: Ji-Dong
authors.initials: JD
authors.lastname: Wang
authors.affiliation: a School of Pharmaceutical Sciences , Central South University , Changsha , China.
authors.forename: Gui-Shan
authors.initials: GS
authors.lastname: Tan
mesh_terms: D000731:Androstanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology; D001203:Ascomycota / Q000378:metabolism*; D005285:Fermentation; D045325:HCT116 Cells; D006801:Humans; D012988:Soil Microbiology
chemical_list: D000731:Androstanes; D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents
keywords: Androstanoid; Curvularia borreriae HS-FG-237; X-ray crystallography; anti-inflammatory activity; cytotoxic activity