title: Efficacy of lumbar cistern drainage combined with intrathecal antibiotherapy for the treatment of ventriculo-subarachnoid infections following surgery for hypertensive intracerebral hemorrhage.
abstract: OBJECTIVE
  The aim of this study was to investigate the efficacy of lumbar cistern drainage combined with intrathecal injection of antibiotics (LCD-ITI) in treating postoperative intracranial infections of hypertensive intracerebral hemorrhage (pHIH-ICI).
  
  
  METHODS
  Sixty pHIH-ICI patients were randomly divided into the control group and the treatment group, with 30 patients in each group. Conventional treatment was performed in the control group, while LCD-ITI was performed in the treatment group. The clinical outcomes, Glasgow Outcome Score (GOS), activities of daily living (ADL) scores, incidence rates of hydrocephalus and other indicators were compared.
  
  
  RESULTS
  The improvement time of clinical symptoms, infection control time and hydrocephalus incidence of the treatment group were significantly lower than the control group (P<0.05). Also the infection control rate, GOS score and ADL score of the treatment group were significantly higher or better than the control group (P<0.05).
  
  
  CONCLUSIONS
  LCD-ITI could improve clinical treatment and prognosis of pHIH-ICI patients.
authors.affiliation: Department of Neurosurgery, The First People's Hospital of Tonglu County, No. 338 Xuesheng Road, Hangzhou, 311500 Zhejiang, China. Electronic address: qihanchencn@163.com.
authors.forename: Q-H
authors.initials: QH
authors.lastname: Chen
authors.affiliation: Department of Neurosurgery, The First People's Hospital of Tonglu County, No. 338 Xuesheng Road, Hangzhou, 311500 Zhejiang, China.
authors.forename: D
authors.initials: D
authors.lastname: Lin
authors.affiliation: Department of Neurosurgery, The First People's Hospital of Tonglu County, No. 338 Xuesheng Road, Hangzhou, 311500 Zhejiang, China.
authors.forename: Q-G
authors.initials: QG
authors.lastname: Yu
authors.affiliation: Department of Neurosurgery, The First People's Hospital of Tonglu County, No. 338 Xuesheng Road, Hangzhou, 311500 Zhejiang, China.
authors.forename: J
authors.initials: J
authors.lastname: Zhou
mesh_terms: D000203:Activities of Daily Living; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000628:therapy*; D004322:Drainage / Q000009:adverse effects / Q000379:methods; D005260:Female; D006801:Humans; D020299:Intracranial Hemorrhage, Hypertensive / Q000175:diagnosis / Q000628:therapy*; D008159:Lumbar Vertebrae / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D013345:Subarachnoid Hemorrhage / Q000150:complications / Q000601:surgery*; D013346:Subarachnoid Space / Q000601:surgery*
chemical_list: D000900:Anti-Bacterial Agents
keywords: Efficacy; Hypertensive intracerebral hemorrhage; Intracranial infection; Intrathecal injection; Lumbar cistern drainage