title: Intravascular ultrasound and near-infrared spectroscopic features of coronary lesions with intraplaque haemorrhage.
abstract: OBJECTIVE
  Intraplaque haemorrhage is considered a major contributor to lesion progression. We assessed coronary lesions with intraplaque haemorrhage using intravascular ultrasound (IVUS) and near-infrared spectroscopy (NIRS).
  
  
  RESULTS
  We evaluated coronary arteries from autopsy hearts using 40MHz IVUS and NIRS and compared the imaging findings to histopathology. A total of 2324 2-mm long histological segments from 101 coronary arteries from 56 autopsy hearts were included. Intraplaque haemorrhage was found pathologically in 0.8% (18/2324) of segments. Segments with intraplaque haemorrhage had more fibroatheromas (FAs) with a greater IVUS plaque burden, a greater prevalence of IVUS echolucent zones, and a higher NIRS-lipid core burden index (LCBI) compared to segments without intraplaque haemorrhage (FAs: 72.2% vs. 18.3%, P < 0.0001; plaque burden: 59.7% [95% confidence interval: 55.5, 64.0] vs. 48.6% [45.8, 51.3], P < 0.0001; echolucent zones: 88.9% vs. 2.8%, P < 0.0001; NIRS-LCBI: 176 [88, 264] vs. 72 [53, 91], P = 0.02). The 16 IVUS superficial echolucent zones with intraplaque haemorrhage had more late FAs but shorter echolucent zone lengths (0.9 mm [0.7, 1.1] vs. 1.7 mm [1.5, 1.9], P < 0.0001) compared to 65 IVUS superficial echolucent zones without intraplaque haemorrhage.
  
  
  CONCLUSIONS
  Intracoronary imaging features consistent with intraplaque haemorrhage included a greater plaque burden, a higher NIRS-LCBI, and a greater prevalence of IVUS echolucent zones compared to lesions without intraplaque haemorrhage.
authors.affiliation: Cardiovascular Research Foundation, 1700 Broadway 9th Floor, New York, NY 10019, USA.
authors.forename: Mitsuaki
authors.initials: M
authors.lastname: Matsumura
authors.affiliation: Cardiovascular Research Foundation, 1700 Broadway 9th Floor, New York, NY 10019, USA.
authors.forename: Gary S
authors.initials: GS
authors.lastname: Mintz
authors.affiliation: Cardiovascular Research Foundation, 1700 Broadway 9th Floor, New York, NY 10019, USA.|Department of Cardiology, Asan Medical Center, Ulsan University, Seoul, South Korea.
authors.forename: Soo-Jin
authors.initials: SJ
authors.lastname: Kang
authors.affiliation: InfraReDx, Inc., Burlington, MA, USA.
authors.forename: Stephen T
authors.initials: ST
authors.lastname: Sum
authors.affiliation: InfraReDx, Inc., Burlington, MA, USA.
authors.forename: Sean P
authors.initials: SP
authors.lastname: Madden
authors.affiliation: University of Maryland Medical Center, Baltimore, MD, USA.|CVPath Institute, Gaithersburg, MD, USA.
authors.forename: Allen P
authors.initials: AP
authors.lastname: Burke
authors.affiliation: Division of Cardiology, William Beaumont Hospital, Royal Oak, MI, USA.
authors.forename: James
authors.initials: J
authors.lastname: Goldstein
authors.affiliation: Cardiovascular Research Foundation, 1700 Broadway 9th Floor, New York, NY 10019, USA.
authors.forename: Rupa
authors.initials: R
authors.lastname: Parvataneni
authors.affiliation: Cardiovascular Research Foundation, 1700 Broadway 9th Floor, New York, NY 10019, USA.|NewYork-Presbyterian Hospital/Columbia University Medical Center, New York, NY, USA.
authors.forename: Gregg W
authors.initials: GW
authors.lastname: Stone
authors.affiliation: CIMIT Vulnerable Plaque and Patient Program, Boston, MA, USA.
authors.forename: James E
authors.initials: JE
authors.lastname: Muller
authors.affiliation: CVPath Institute, Gaithersburg, MD, USA.
authors.forename: Renu
authors.initials: R
authors.lastname: Virmani
authors.affiliation: Cardiovascular Research Foundation, 1700 Broadway 9th Floor, New York, NY 10019, USA.|NewYork-Presbyterian Hospital/Columbia University Medical Center, New York, NY, USA.
authors.forename: Akiko
authors.initials: A
authors.lastname: Maehara
mesh_terms: D000368:Aged; D001344:Autopsy; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging*; D005260:Female; D006470:Hemorrhage / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D058226:Plaque, Atherosclerotic / Q000000981:diagnostic imaging*; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D018084:Ultrasonography, Interventional / Q000379:methods*
keywords: imaging; intraplaque haemorrhage; intravascular ultrasound