title: The levels of visceral adipose tissue-derived serpin, omentin-1 and tumor necrosis factor-α in the gingival crevicular fluid of obese patients following periodontal therapy.
abstract: The aim of this clinical study was to determine levels of visceral adipose tissue-derived serpin (vaspin), omentin-1, and tumor necrosis factor-alpha (TNF-α) in the gingival crevicular fluid (GCF) of obese and non-obese periodontitis patients following nonsurgical periodontal therapy. Seventy-six subjects were separated into four groups according to periodontal and anthropometric measurements: a periodontal-healthy group, a chronic periodontitis (CP) group, a periodontal-healthy with obesity group, and a CP with obesity group. Nonsurgical periodontal treatment was administered to periodontitis patients. Before treatment and at 6 weeks after treatment, GCF samples were analyzed and clinical periodontal parameters were examined. Enzyme-linked immunosorbent assays were used to measure the levels of vaspin, omentin-1, and TNF-α. Obese and non-obese CP patients displayed higher levels of vaspin and TNF-α (P < 0.008), which declined following treatment (P < 0.025), and lower omentin levels (P < 0.008), which increased after treatment (P < 0.025). There was a negative correlation between the total amount of vaspin and omentin-1 in all groups. Obese and non-obese patients had opposing levels of vaspin and omentin-1 in the GCF; therefore, these may represent diagnostic and prognostic indicators of periodontal disease and therapeutic outcome.(J Oral Sci 58, 465-473, 2016).
authors.affiliation: Department of Periodontology, Faculty of Dentistry, Bulent Ecevit University.
authors.forename: Umut
authors.initials: U
authors.lastname: Balli
authors.forename: Seyma
authors.initials: S
authors.lastname: Bozkurt Dogan
authors.forename: Figen
authors.initials: F
authors.lastname: Ongoz Dede
authors.forename: Erdim
authors.initials: E
authors.lastname: Sertoglu
authors.forename: Gonca Cayır
authors.initials: GC
authors.lastname: Keles
mesh_terms: D000328:Adult; D016207:Cytokines / Q000378:metabolism*; D005260:Female; D058851:GPI-Linked Proteins / Q000378:metabolism; D005883:Gingival Crevicular Fluid / Q000378:metabolism*; D006801:Humans; D050152:Intra-Abdominal Fat / Q000378:metabolism*; D037102:Lectins / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000378:metabolism*; D010518:Periodontitis / Q000150:complications / Q000628:therapy*; D015843:Serpins / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
chemical_list: D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D037102:Lectins; D015843:Serpins; D014409:Tumor Necrosis Factor-alpha