title: Visual experience dependent regulation of neuronal structure and function by histone deacetylase 1 in developing Xenopus tectum in vivo.
abstract: Histone deacetylase 1 (HDAC1) is thought to play pivotal roles in neurogenesis and neurodegeneration. However, the role of HDAC1 in neuronal growth and structural plasticity in the developing brain in vivo remains unclear. Here, we show that in the optic tectum of Xenopus laevis, HDAC1 knockdown dramatically decreased the frequency of AMPAR-mediated synaptic currents and increased the frequency of GABAAR-mediated currents, whereas HDAC1 overexpression significantly decreased the frequency of GABAAR-mediated synaptic currents. Both HDAC1 knockdown and overexpression adversely affected dendritic arbor growth and visual experience-dependent structural plasticity. Furthermore, HDAC1 knockdown decreased BDNF expression via a mechanism that involves acetylation of specific histone H4 residues at lysine K5. In particular, the deficits in dendritic growth and visually guided avoidance behavior in HDAC1-knockdown tadpoles could be rescued by acute tectal infusion of BDNF. These results establish a relationship between HDAC1 expression, histone H4 modification and BDNF signaling in the visual-experience dependent regulation of dendritic growth, structural plasticity and function in intact animals in vivo. © 2016 Wiley Periodicals, Inc. Develop Neurobiol 77: 947-962, 2017.
authors.affiliation: Zhejiang Key Laboratory of Organ Development and Regeneration, College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, Zhejiang, 310036, China.
authors.forename: Hangze
authors.initials: H
authors.lastname: Ruan
authors.affiliation: Zhejiang Key Laboratory of Organ Development and Regeneration, College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, Zhejiang, 310036, China.
authors.forename: Juanmei
authors.initials: J
authors.lastname: Gao
authors.affiliation: Zhejiang Key Laboratory of Organ Development and Regeneration, College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, Zhejiang, 310036, China.
authors.forename: Xianjie
authors.initials: X
authors.lastname: Qi
authors.affiliation: Department of Neurosurgery, Nanjing Medical University Affiliated Jiangsu Cancer Hospital, Nanjing, Jiangsu, 210029, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Tao
authors.affiliation: Zhejiang Key Laboratory of Organ Development and Regeneration, College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, Zhejiang, 310036, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Guo
authors.affiliation: Zhejiang Key Laboratory of Organ Development and Regeneration, College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, Zhejiang, 310036, China.
authors.forename: Zhaoyi
authors.initials: Z
authors.lastname: Guo
authors.affiliation: Zhejiang Key Laboratory of Organ Development and Regeneration, College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, Zhejiang, 310036, China.
authors.forename: Lijun
authors.initials: L
authors.lastname: Zheng
authors.affiliation: Zhejiang Key Laboratory of Organ Development and Regeneration, College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, Zhejiang, 310036, China.
authors.forename: Yaling
authors.initials: Y
authors.lastname: Song
authors.affiliation: Zhejiang Key Laboratory of Organ Development and Regeneration, College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, Zhejiang, 310036, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Liao
authors.affiliation: Zhejiang Key Laboratory of Organ Development and Regeneration, College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, Zhejiang, 310036, China.
authors.forename: Wanhua
authors.identifier: 0000-0002-5178-9561
authors.initials: W
authors.lastname: Shen
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000502:physiology; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism; D006063:Chorionic Gonadotropin; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology; D055785:Gene Knockdown Techniques; D056284:Histone Deacetylase 1 / Q000235:genetics / Q000378:metabolism*; D006657:Histones / Q000378:metabolism; D053444:Inhibitory Postsynaptic Potentials / Q000502:physiology; D055369:Miniature Postsynaptic Potentials / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000201:enzymology*; D013477:Superior Colliculi / Q000166:cytology / Q000201:enzymology* / Q000254:growth & development*; D046509:Tissue Culture Techniques; D014796:Visual Perception / Q000502:physiology*; D029867:Xenopus Proteins / Q000235:genetics / Q000378:metabolism*; D014982:Xenopus laevis
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D006063:Chorionic Gonadotropin; D006657:Histones; D029867:Xenopus Proteins; C000627078:HDAC1 protein, Xenopus; D056284:Histone Deacetylase 1
keywords: BDNF; Xenopus laevis; histone deacetylase; structural plasticity; visual experience