title: Genetic impact on the treatment & management of Hirschsprung disease.
abstract: BACKGROUND
  The identification of Hirschsprung's disease (HD) as a genetic condition has been a major step forward in understanding the development of the enteric nervous system and conditions arising from ganglion cell maldevelopment.
  
  
  METHODS
  A study of the role of genetics in HD was carried out based on previously published findings from more than 400 cases of HD.
  
  
  RESULTS
  There are at least 7 pertinent clinical questions related to HD which were further investigated. These included: diagnosis, familial recurrence, long segment and total colonic aganglionosis, syndromic associations, the question of HD-associated enterocolitis, potential causes of postoperative obstructive symptoms after successful surgery, and the apparent low prevalence in premature infants. This review aimed at evaluating the most important concepts of where we have got to in our understanding of where genetic solutions/directions to these clinical problems might lie. Possible genetic reasons for the low prevalence in premature infants was also considered and the possible plasticity of the ENS at that stage as a potential "door of hope" in the future management of HD.
  
  
  CONCLUSIONS
  The study of genetics has made a massive contribution to the understanding and management of HD. It opens a "door of hope" to the future management of the condition.
  
  
  METHODS
  Level V.
authors.affiliation: Department of Paediatric Surgery, University of Stellenbosch, Faculty of Medicine and Health Sciences, Cape Town, South Africa. Electronic address: swm@sun.ac.za.
authors.forename: Sam W
authors.initials: SW
authors.lastname: Moore
mesh_terms: D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006627:Hirschsprung Disease / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D006801:Humans; D000090063:Proto-Oncogene Mas
chemical_list: D005819:Genetic Markers; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas
keywords: Endothelin-B receptor gene; Hirschsprung's disease; MEN2 syndrome; RET proto-oncogene; Total colonic aganglionosis