title: Gender Difference in Distribution of Estrogen and Androgen Receptors in Intestinal-type Gastric Cancer.
abstract: Gender difference in survival of patients with gastric cancer is not well investigated. The aim of this study was to analyze the gender-related distribution of estrogen receptor alpha (ERα) and androgen receptor (AR) in the epithelium and stroma of intestinal-type gastric cancer.
  
  
  
  Immunohistochemical analysis was performed in 60 patients (42% females).
  
  
  
  In gastric cancer patients, frequency of ERα-positive cells was lower in epithelium than in healthy individuals, but not significantly. In stroma and epithelium, AR-positive cells were absent from samples of women with T1 and T2 stage disease, while in men, their frequency was significantly increased in stroma of those with T3 and T4 stages and was significantly higher compared to women. AR-positive cells in stroma were fibroblasts, myofibroblasts and mast cells.
  
  
  
  To our knowledge, this study is the first to show gender differences in the distribution and frequency of AR-positive cells in neoplastic stroma of gastric cancer.
authors.affiliation: General Hospital Nova Gradiska, Nova Gradiska, Croatia.|School of Medicine, J.J. Strossmayer University of Osijek, Osijek, Croatia.
authors.forename: Zoran
authors.initials: Z
authors.lastname: Jukic
authors.affiliation: Sestre Milosrdnice University Hospital Center, Zagreb, Croatia.
authors.forename: Petra
authors.initials: P
authors.lastname: Radulovic
authors.affiliation: Rudjer Boskovic Institute, Zagreb, Croatia.
authors.forename: Ranko
authors.initials: R
authors.lastname: Stojković
authors.affiliation: Sestre Milosrdnice University Hospital Center, Zagreb, Croatia.
authors.forename: August
authors.initials: A
authors.lastname: Mijic
authors.affiliation: Rebro, Clinical Hospital Centre, Zagreb, Croatia.|School of Medicine, J.J. Strossmayer University of Osijek, Osijek, Croatia.
authors.forename: Josip
authors.initials: J
authors.lastname: Grah
authors.affiliation: Sestre Milosrdnice University Hospital Center, Zagreb, Croatia.|School of Medicine, University of Zagreb, Zagreb, Croatia.
authors.forename: Bozo
authors.initials: B
authors.lastname: Kruslin
authors.affiliation: Srebrnjak Clinical Hospital, Zagreb, Croatia.
authors.forename: Zeljko
authors.initials: Z
authors.lastname: Ferencic
authors.affiliation: Institute for Medical Research and Occupational Health, Zagreb, Croatia afucic@imi.hr.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Fucic
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004848:Epithelium / Q000378:metabolism; D047628:Estrogen Receptor alpha / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011944:Receptors, Androgen / Q000378:metabolism*; D012727:Sex Characteristics; D013274:Stomach Neoplasms / Q000378:metabolism*
chemical_list: C410798:AR protein, human; C506487:ESR1 protein, human; D047628:Estrogen Receptor alpha; D011944:Receptors, Androgen
keywords: Intestinal gastric cancer; androgen receptor; estrogen receptor; mast cell; myofibroblast; stroma