title: Remote controlled drug release from multi-functional Fe3O4/GO/Chitosan microspheres fabricated by an electrospray method.
abstract: The construction of multifunctional microspheres for remote controlled drug release requires the exquisite selection of composite materials and preparation approaches. In this study, chitosan, an amino polysaccharide, was blended with inorganic nanocomponents, Fe3O4and graphene oxide (GO) and electrosprayed to fabricate uniform microspheres with the diameters ranging from 100μm to 1100μm. An anti-cancer drug, doxorubicin (DOX), was loaded to the microspheres by an adsorption or embedding method. The microsphere is responsive to magnetic fields due to the presence of Fe3O4, and the incorporation of GO enhanced the drug loading capacity. The fast stimuli-responsive release of DOX can be facilely controlled by using NIR irradiation due to the strong photo-thermal conversion of Fe3O4and GO.In addition, ultrasound was used as another external stimulus for DOX release. The results suggest the Fe3O4/GO/Chitosan microspheres fabricated by the electrospray method provide an efficient platform for remote controlled drug release, which may have potential applications in drug eluting microspheres.
authors.affiliation: School of Resource and Environmental Science, Hubei Biomass-Resource Chemistry and Environmental Biotechnology Key Laboratory, Wuhan University, Wuhan 430072, PR China. Electronic address: lfrcs@163.com.
authors.forename: Sheng
authors.initials: S
authors.lastname: Li
authors.affiliation: School of Resource and Environmental Science, Hubei Biomass-Resource Chemistry and Environmental Biotechnology Key Laboratory, Wuhan University, Wuhan 430072, PR China. Electronic address: xiaoling9119@whu.edu.cn.
authors.forename: Ling
authors.initials: L
authors.lastname: Xiao
authors.affiliation: School of Resource and Environmental Science, Hubei Biomass-Resource Chemistry and Environmental Biotechnology Key Laboratory, Wuhan University, Wuhan 430072, PR China. Electronic address: hbdeng@whu.edu.cn.
authors.forename: Hongbing
authors.initials: H
authors.lastname: Deng
authors.affiliation: School of Resource and Environmental Science, Hubei Biomass-Resource Chemistry and Environmental Biotechnology Key Laboratory, Wuhan University, Wuhan 430072, PR China. Electronic address: shixwwhu@163.com.
authors.forename: Xiaowen
authors.initials: X
authors.lastname: Shi
authors.affiliation: School of Resource and Environmental Science, Hubei Biomass-Resource Chemistry and Environmental Biotechnology Key Laboratory, Wuhan University, Wuhan 430072, PR China. Electronic address: caoqh@whu.edu.cn.
authors.forename: Qihua
authors.initials: Q
authors.lastname: Cao
mesh_terms: D000327:Adsorption; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004317:Doxorubicin / Q000008:administration & dosage* / Q000737:chemistry*; D004337:Drug Carriers; D016503:Drug Delivery Systems; D065546:Drug Liberation; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D060526:Magnetic Fields; D008863:Microspheres; D054118:Nanospheres; D010087:Oxides / Q000737:chemistry*; D010316:Particle Size; D014961:X-Ray Diffraction
chemical_list: D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D010087:Oxides; D006108:Graphite; D004317:Doxorubicin; D048271:Chitosan
keywords: Chitosan microsphere; Electrospray; NIR; Remote controlled release; Ultrasound