title: Prospective pilot study of CT-guided microwave ablation in the treatment of osteoid osteomas.
abstract: OBJECTIVE
  The aims of this work were to assess the feasibility and efficacy of CT-guided microwave ablation (MWA) in the treatment of osteoid osteomas (OOs).
  
  
  METHODS
  Thirteen consecutive patients (range 11-31 years old) presenting with OO were prospectively included and treated by CT-guided MWA. Power and duration of MWA were both recorded. The patient's pain was assessed using a numeric pain rating scale (NRS), and side effects were recorded during procedures, after 1 day, 7 days and 1 month. The nidus vascularization and the volume of necrosis induced by MWA were assessed using contrast-enhanced MRI. Success was defined as the complete relief of the patient's pain 1 month after the first procedure, associated with necrosis of the nidus on follow-up MRI.
  
  
  RESULTS
  The success rate was up to 92.3% (12/13). At 1 day, 7 days and 1 month, the median NRSs were respectively 5 [interquartile range (IQR) 2-5], 0 (IQR 0-1) and 0 (IQR 0-0). Side effects observed were one partial and self-resolving lesion of a sensory branch of the radial nerve and two skin burns. The median power of the MWA used was 60 W (IQR 50-60) with a 1.5-min duration (IQR 1-2), leading to MWA-induced necrosis measuring on average 23 × 15 × 16 mm.
  
  
  CONCLUSIONS
  CT-guided MWA of OO has a success rate that appears to be almost similar to that of laser or radiofrequency ablation, but care must be taken to prevent nerve or skin lesions.
authors.affiliation: Department of Musculoskeletal Imaging, University Hospital of Besancon, 25000, Besancon, France.
authors.forename: Clara
authors.initials: C
authors.lastname: Prud'homme
authors.affiliation: Department of Musculoskeletal Imaging, University Hospital of Besancon, 25000, Besancon, France.
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Nueffer
authors.affiliation: Department of Musculoskeletal Imaging, University Hospital of Besancon, 25000, Besancon, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Runge
authors.affiliation: Department of Musculoskeletal Imaging, University Hospital of Besancon, 25000, Besancon, France.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Dubut
authors.affiliation: Department of Musculoskeletal Imaging, University Hospital of Besancon, 25000, Besancon, France.|I4S Laboratory, INSERM EA4268, University of Franche-Comte, 25000, Besancon, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Kastler
authors.affiliation: Department of Musculoskeletal Imaging, University Hospital of Besancon, 25000, Besancon, France. radio.aubry@free.fr.|Nanomedecine Laboratory, INSERM EA4662, University of Franche-Comte, 25000, Besancon, France. radio.aubry@free.fr.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Aubry
mesh_terms: D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000601:surgery*; D017115:Catheter Ablation / Q000379:methods*; D002648:Child; D003287:Contrast Media; D005260:Female; D006801:Humans; D008297:Male; D008872:Microwaves / Q000627:therapeutic use*; D010017:Osteoma, Osteoid / Q000000981:diagnostic imaging / Q000601:surgery*; D010147:Pain Measurement; D010865:Pilot Projects; D011446:Prospective Studies; D015641:Radiography, Interventional; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D003287:Contrast Media
keywords: CT-guided procedure; Efficacy; Microwave ablation; Osteoid osteoma; Thermoablation; Treatment