title: Assessment of Corneal and Tear Film Parameters in Rheumatoid Arthritis Patients Using Anterior Segment Spectral Domain Optical Coherence Tomography.
abstract: OBJECTIVE
  To study the corneal changes in rheumatoid arthritis (RA) patients in vivo, using spectral domain anterior segment optical coherence tomography (AS-OCT).
  
  
  METHODS
  A case-control study was done on 43 RA patients and 40 controls. The disease activity score (DAS28-ESR) was calculated and all participants had lower tear meniscus, corneal thickness, and epithelial thickness evaluation using AS-OCT.
  
  
  RESULTS
  The lower tear meniscus height (LTMH) and the lower tear meniscus area (LTMA) were significantly lower in the RA patients than in controls (p < 0.001). RA patients also had a significantly thinner central corneal thickness (p = 0.02) and their epithelium was found to be thinner in the superotemporal peripheral sector.
  
  
  CONCLUSIONS
  The LTMH and LTMA are significantly reduced in RA patients, despite the absence of clinical diagnosis of dry eye. RA patients have thinner corneal thickness and epithelial thickness than controls, which did not correlate with either disease duration or activity.
authors.affiliation: a Department of Ophthalmology , Cairo University , Cairo , Egypt.
authors.forename: Dina
authors.initials: D
authors.lastname: El-Fayoumi
authors.affiliation: a Department of Ophthalmology , Cairo University , Cairo , Egypt.
authors.forename: Maha Mohamed
authors.initials: MM
authors.lastname: Youssef
authors.affiliation: a Department of Ophthalmology , Cairo University , Cairo , Egypt.
authors.forename: Mohamed Mahmoud
authors.initials: MM
authors.lastname: Khafagy
authors.affiliation: a Department of Ophthalmology , Cairo University , Cairo , Egypt.
authors.forename: Nashwa
authors.initials: N
authors.lastname: Badr El Dine
authors.affiliation: b Department of Rheumatology and Rehabilitation , Cairo University , Cairo , Egypt.
authors.forename: Wafaa
authors.initials: W
authors.lastname: Gaber
mesh_terms: D000328:Adult; D000869:Anterior Eye Segment / Q000473:pathology; D001172:Arthritis, Rheumatoid / Q000150:complications*; D003315:Cornea / Q000473:pathology*; D015352:Dry Eye Syndromes / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D013666:Tears / Q000737:chemistry*; D041623:Tomography, Optical Coherence / Q000379:methods
keywords: AS-OCT; corneal epithelium thickness; dry eye; lower tear meniscus; rheumatoid arthritis