title: Pharmacokinetic and pharmacodynamic interactions in anaesthesia. A review of current knowledge and how it can be used to optimize anaesthetic drug administration.
abstract: This review describes the basics of pharmacokinetic and pharmacodynamic drug interactions and methodological points of particular interest when designing drug interaction studies. It also provides an overview of the available literature concerning interactions, with emphasis on graphic representation of interactions using isoboles and response surface models. It gives examples on how to transform this knowledge into clinically and educationally applicable (bedside) tools.
authors.affiliation: Department of Anesthesiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands j.p.van.den.berg@umcg.nl.
authors.forename: J P
authors.initials: JP
authors.lastname: van den Berg
authors.affiliation: Department of Anesthesiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.|Department of Anesthesiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
authors.forename: H E M
authors.initials: HE
authors.lastname: Vereecke
authors.affiliation: Department of Anesthesiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
authors.forename: J H
authors.initials: JH
authors.lastname: Proost
authors.affiliation: Department of Anesthesiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
authors.forename: D J
authors.initials: DJ
authors.lastname: Eleveld
authors.affiliation: Department of Anesthesiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
authors.forename: J K G
authors.initials: JK
authors.lastname: Wietasch
authors.affiliation: Department of Anesthesiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
authors.forename: A R
authors.initials: AR
authors.lastname: Absalom
authors.affiliation: Department of Anesthesiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.|Department of Anesthesiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
authors.forename: M M R F
authors.initials: MM
authors.lastname: Struys
mesh_terms: D000777:Anesthetics / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology*; D015195:Drug Design; D004347:Drug Interactions; D006801:Humans
chemical_list: D000777:Anesthetics
keywords: anesthetics; drug interactions; pharmacology