title: Prospective study of definitive chemoradiation in locally or regionally advanced squamous cell carcinoma of the skin.
abstract: The purpose of this study was to present our evaluation of the outcomes of concurrent chemoradiotherapy (CRT) in patients with locally advanced cutaneous squamous cell carcinoma (SCC).
  
  
  
  This was a prospective phase II study. The primary endpoint was complete response (CR). Patients with locally/regionally advanced cutaneous SCC deemed unsuitable for surgery received definitive radiotherapy (RT; 70 Gy in 35fractions) and concurrent weekly platinum-based chemotherapy (cisplatin 40 mg/m2 or carboplatin area under the curve 2).
  
  
  
  Twenty-one patients were enrolled in this study. Eighteen patients had a locally advanced primary or nodal disease in the head and neck region with 66% having stage IV nonmetastatic disease. Of 19 evaluable patients, 10 achieved a CR to definitive CRT with 2 further patients rendered disease-free by salvage surgery for an overall CR of 63%.
  
  
  
  This is the only prospective series of CRT for cutaneous SCC. A high CR rate was documented in patients with locoregional advanced disease who were unable to undergo surgery. © 2016 Wiley Periodicals, Inc. Head Neck 39: 679-683, 2017.
authors.affiliation: Cancer Care Services, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.
authors.forename: Michelle K
authors.identifier: 0000-0002-1620-1961
authors.initials: MK
authors.lastname: Nottage
authors.affiliation: Cancer Care Services, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.
authors.forename: Charles
authors.initials: C
authors.lastname: Lin
authors.affiliation: Cancer Care Services, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.|The School of Medicine, University of Queensland, Herston, Australia.
authors.forename: Brett G M
authors.initials: BG
authors.lastname: Hughes
authors.affiliation: Cancer Care Services, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.|The School of Medicine, University of Queensland, Herston, Australia.
authors.forename: Lizbeth
authors.initials: L
authors.lastname: Kenny
authors.affiliation: Queensland Institute of Medical Research, Herston, Queensland, Australia.
authors.forename: David D
authors.initials: DD
authors.lastname: Smith
authors.affiliation: Cancer Care Services, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.|The School of Medicine, University of Queensland, Herston, Australia.
authors.forename: Kathleen
authors.initials: K
authors.lastname: Houston
authors.affiliation: Cancer Care Services, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.|The School of Medicine, University of Queensland, Herston, Australia.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Francesconi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000401:mortality* / Q000473:pathology / Q000628:therapy*; D059248:Chemoradiotherapy / Q000379:methods*; D016001:Confidence Intervals; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D011379:Prognosis; D011446:Prospective Studies; D011879:Radiotherapy Dosage; D018570:Risk Assessment; D012878:Skin Neoplasms / Q000401:mortality* / Q000473:pathology / Q000628:therapy*; D016019:Survival Analysis; D016896:Treatment Outcome
keywords: carcinoma; chemoradiotherapy; prospective studies; skin neoplasms; squamous cell