title: Gene expression changes in tumor free tongue tissue adjacent to tongue squamous cell carcinoma.
abstract: Due to the high frequency of loco-regional recurrences, which could be explained by changes in the field surrounding the tumor, patients with squamous cell carcinoma of head and neck show poor survival. Here we identified a total of 554 genes as dysregulated in clinically tumor free tongue tissue in patients with tongue tumors when compared to healthy control tongue tissue. Among the top dysregulated genes when comparing control and tumor free tissue were those involved in apoptosis (CIDEC, MUC1, ZBTB16, PRNP, ECT2), immune response (IFI27) and differentiation (KRT36). Data suggest that these are important findings which can aid in earlier diagnosis of tumor development, a relapse or a novel squamous cell carcinoma of the tongue, in the absence of histological signs of a tumor.
authors.affiliation: Department of Medical Biosciences/Pathology, Umeå University, SE - 901 85 Umeå, Sweden.
authors.forename: Linda
authors.initials: L
authors.lastname: Boldrup
authors.affiliation: Department of Medical Biosciences/Pathology, Umeå University, SE - 901 85 Umeå, Sweden.
authors.forename: Xiaolian
authors.initials: X
authors.lastname: Gu
authors.affiliation: RECAMO, Masaryk Memorial Cancer Institute, 656 53 Brno, Czech Republic.
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Coates
authors.affiliation: Department of Clinical Sciences/ENT Umeå University, SE - 901 85 Umeå, Sweden.
authors.forename: Lena
authors.initials: L
authors.lastname: Norberg-Spaak
authors.affiliation: Department of Medical Biosciences/Pathology, Umeå University, SE - 901 85 Umeå, Sweden.|RECAMO, Masaryk Memorial Cancer Institute, 656 53 Brno, Czech Republic.|Institut de Génétique Moléculaire, Université Paris 7, Hôpital St. Louis, 75010 Paris, France.
authors.forename: Robin
authors.initials: R
authors.lastname: Fahraeus
authors.affiliation: Department of Clinical Sciences/ENT Umeå University, SE - 901 85 Umeå, Sweden.|Department of Surgical Sciences/ENT, Uppsala University,752 36 Uppsala, Sweden.
authors.forename: Göran
authors.initials: G
authors.lastname: Laurell
authors.affiliation: Department of Clinical Sciences/ENT Umeå University, SE - 901 85 Umeå, Sweden.
authors.forename: Torben
authors.initials: T
authors.lastname: Wilms
authors.affiliation: Department of Medical Biosciences/Pathology, Umeå University, SE - 901 85 Umeå, Sweden.
authors.forename: Karin
authors.initials: K
authors.lastname: Nylander
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D020869:Gene Expression Profiling; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D015996:Survival Rate; D014059:Tongue / Q000378:metabolism*; D014062:Tongue Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor
keywords: RNA expression; field cancerization; tongue cancer