title: A Magnetic Soft Endoscopic Capsule-Inflated Intragastric Balloon for Weight Management.
abstract: Overweight and obesity have been identified as a cause of high risk diseases like diabetes and cancer. Although conventional Intragastric Balloons (IGBs) have become an efficient and less invasive method for overweight and obesity treatment, the use of conventional tools such as catheter or endoscope to insert and remove the IGBs from the patient's body causes nausea, vomiting, discomfort, and even gastric mucous damage. To eliminate these drawbacks, we develop a novel magnetic soft capsule device with gas-filled balloon inflation. The balloon is made from a thin and biocompatible material that can be inflated to a desired volume using biocompatible effervescent chemicals. In addition, both the outer balloon and inner capsule are designed to be soft and chemical resistance. The soft capsule shell is fabricated using scaffold-solvent approach while the outer balloon utilizes a novel fabrication approach for 3D spherical structure. A prototype of the proposed capsule and balloon is given. Experiments are successfully carried out in stimulated gastric environment and fresh porcine stomach to validate the effectiveness and reliability of the proposed approach.
authors.affiliation: California NanoSystems Institute (CNSI), University of California, Santa Barbara, Room 2810, Elings Hall, Mesa Road, CA, 93106, USA.
authors.forename: Thanh Nho
authors.initials: TN
authors.lastname: Do
authors.affiliation: Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University of Health System, 119260 Singapore.
authors.forename: Khek Yu
authors.initials: KY
authors.lastname: Ho
authors.affiliation: School of Mechanical and Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798 Singapore.
authors.forename: Soo Jay
authors.initials: SJ
authors.lastname: Phee
mesh_terms: D000818:Animals; D002214:Capsules; D002245:Carbon Dioxide / Q000737:chemistry; D004129:Dimethylpolysiloxanes / Q000737:chemistry; D019723:Endoscopes; D004724:Endoscopy / Q000379:methods*; D004867:Equipment Design; D015905:Gastric Balloon; D008280:Magnetics; D059346:Magnets; D023421:Models, Animal; D009325:Nausea / Q000517:prevention & control; D009765:Obesity / Q000601:surgery*; D050177:Overweight / Q000601:surgery*; D066330:Printing, Three-Dimensional; D015203:Reproducibility of Results; D013270:Stomach; D013552:Swine; D015431:Weight Loss
chemical_list: D002214:Capsules; D004129:Dimethylpolysiloxanes; D002245:Carbon Dioxide; C013830:baysilon