title: Human Papilloma Virus Detection by INNOLiPA HPV in Prostate Tissue from Men of Northeast Mexico
abstract: Background: Prostatic adenocarcinoma by Prosate cancer (PCa) is the most prevalent cancer and the second cause of
  cancer-related death among men in the Western world. Human papilloma virus (HPV) may be considered as a preventable
  risk factor. In this study, we assessed the frequencies of HPV infection in prostatic adenocarcinoma and benign prostatic
  hyperplasia (BPH) cases in Northeast Mexico. Materials and Methods: A total of 87 paraffin-embedded blocks (from
  25 and 62 patients with definite diagnoses of BPH and adenocarcinoma, respectively) were selected and subjected to
  INNOLiPA HPV Genotyping to detect 28 high- and low-risk HPV types. The rates of infection were compared in the two
  studied groups. Results: INNOLiPA HPV demonstrated great sensitivity for HPV detection on paraffin-embedded tissue.
  Global prevalence was 14.9% (13/87). HPV infection was positive in 19.4% (12/62) of patients with adenocarcinoma
  and 4.0% (1/25) of patients with BPH. HPV-11, which is considered to be low risk, was more prevalent. Interestingly,
  one patient with BPH and six with prostate cancer showed examples considered to be high risk (HPV-18, -51, -52,
  and -66). Conclusion: A higher rate of HPV infection among Mexican patients with prostatic carcinoma than among
  those with BPH was observed. HPV infections may thus contribute to the risk of prostate cancer. Further studies are
  required to elucidate any roles of HPV infection in prostate disease in Mexico and the effect of prevention and treatment
  of HPV infection on prostatic adenocarcinoma.
authors.affiliation: Department of Genetics, Centro De Investigación Biomédica Del Noreste, Instituto Mexicano Del Seguro Social, 64720,Mexico. Email: elvacortes@cibinmty.net
authors.forename: Martha I
authors.initials: MI
authors.lastname: Dávila-Rodríguez
authors.forename: Cesar V
authors.initials: CV
authors.lastname: Ignacio Morales
authors.forename: Anel R
authors.initials: AR
authors.lastname: Aragón Tovar
authors.forename: Delia
authors.initials: D
authors.lastname: Olache Jimenez
authors.forename: Edmundo
authors.initials: E
authors.lastname: Castelán Maldonado
authors.forename: Sandra
authors.initials: S
authors.lastname: Lara Miranda
authors.forename: Elva I
authors.initials: EI
authors.lastname: Cortés Gutiérrez
keywords: Prostatic carcinoma; benign prostatic hyperplasia; human papilloma virus; INNOLiPA HPV; Mexico