title: A new phytoecdysteroid from the roots of Achyranthes bidentata Bl.
abstract: A new phytoecdysteroid compound, named Niuxixinsterone D (1), together with two known phytoecdysteroid compounds (2 and 3) were isolated from Achyranthes bidentata Bl.. The structure of the new compound was elucidated by extensive spectral analysis, including HR-ESI-MS, 1D and 2D NMR methods. Compounds 1-3 were tested for their inhibitory effects against LPS-induced NO production in RAW 264.7 macrophages, and compound 1 and 3 exhibited anti-neuroinflammatory activity with inhibited 29.7 and 26.0% NO production.
authors.affiliation: a Key Laboratory of Chinese Materia Medica , Heilongjiang University of Chinese Medicine, Ministry of Education , Harbin , China.
authors.forename: Liu
authors.initials: L
authors.lastname: Yang
authors.affiliation: a Key Laboratory of Chinese Materia Medica , Heilongjiang University of Chinese Medicine, Ministry of Education , Harbin , China.|b Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education , Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences , Beijing , China.
authors.forename: Hai
authors.initials: H
authors.lastname: Jiang
authors.affiliation: a Key Laboratory of Chinese Materia Medica , Heilongjiang University of Chinese Medicine, Ministry of Education , Harbin , China.
authors.forename: Mei-Ling
authors.initials: ML
authors.lastname: Yan
authors.affiliation: a Key Laboratory of Chinese Materia Medica , Heilongjiang University of Chinese Medicine, Ministry of Education , Harbin , China.
authors.forename: Xu-Dong
authors.initials: XD
authors.lastname: Xing
authors.affiliation: a Key Laboratory of Chinese Materia Medica , Heilongjiang University of Chinese Medicine, Ministry of Education , Harbin , China.
authors.forename: Yan-Yan
authors.initials: YY
authors.lastname: Zhang
authors.affiliation: c School of Pharmacy , Hainan Medical University , Haikou , China.
authors.forename: Na
authors.initials: N
authors.lastname: Wei
authors.affiliation: a Key Laboratory of Chinese Materia Medica , Heilongjiang University of Chinese Medicine, Ministry of Education , Harbin , China.
authors.forename: Bing-You
authors.initials: BY
authors.lastname: Yang
authors.affiliation: a Key Laboratory of Chinese Materia Medica , Heilongjiang University of Chinese Medicine, Ministry of Education , Harbin , China.|d School of Traditional Chinese Medicine , Guangdong Pharmaceutical University , Guangzhou , China.
authors.forename: Qiu-Hong
authors.initials: QH
authors.lastname: Wang
authors.affiliation: a Key Laboratory of Chinese Materia Medica , Heilongjiang University of Chinese Medicine, Ministry of Education , Harbin , China.
authors.forename: Hai-Xue
authors.initials: HX
authors.lastname: Kuang
mesh_terms: D029044:Achyranthes / Q000737:chemistry*; D026461:Ecdysteroids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D018517:Plant Roots / Q000737:chemistry
chemical_list: D026461:Ecdysteroids; C000619995:niuxixinsterone D
keywords: Achyranthes bidentata Bl.; RAW 264.7; niuxixinsterone; phytoecdysteroid