title: Dahurelmusin A, a Hybrid Peptide-Polyketide from Elymus dahuricus Infected by the Epichloë bromicola Endophyte.
abstract: One novel hybrid peptide-polyketide, dahurelmusin A (1), was isolated from Elymus dahuricus infected by the Epichloë bromicola endophyte. Comprehensive spectroscopic analysis revealed that 1 is the first example of hybrid peptide-polyketide possessing an unprecedented 5-hydroxy-2,2,4,6-tetramethyl-3-oxooctanoic acid moiety. The single-crystal X-ray diffraction analyses allowed the absolute configuration assignment of this compound. Compound 1 also exhibited significant insecticidal activities against Rhopalosiphum padi and Brevicoryne brassicae with LC50values of 0.092 and 0.251 mM, respectively.
authors.affiliation: State Key Laboratory of Grassland Agro-Ecosystems, College of Pastoral Agriculture Science and Technology, Lanzhou University , Lanzhou 730020, China.
authors.forename: Qiu-Yan
authors.identifier: 0000-0003-1469-9353
authors.initials: QY
authors.lastname: Song
authors.affiliation: Institute of Plant Protection, Gansu Academy of Agricultural Sciences , Lanzhou 730070, China.
authors.forename: Hai-Tao
authors.initials: HT
authors.lastname: Yu
authors.affiliation: State Key Laboratory of Grassland Agro-Ecosystems, College of Pastoral Agriculture Science and Technology, Lanzhou University , Lanzhou 730020, China.
authors.forename: Xing-Xu
authors.initials: XX
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Grassland Agro-Ecosystems, College of Pastoral Agriculture Science and Technology, Lanzhou University , Lanzhou 730020, China.
authors.forename: Zhi-Biao
authors.initials: ZB
authors.lastname: Nan
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University , Lanzhou 730000, China.
authors.forename: Kun
authors.identifier: 0000-0002-3856-3672
authors.initials: K
authors.lastname: Gao
mesh_terms: D000818:Animals; D001042:Aphids; D002210:Caprylates / Q000737:chemistry; D031749:Elymus / Q000737:chemistry*; D060026:Endophytes / Q000737:chemistry*; D055329:Epichloe / Q000737:chemistry*; D007306:Insecticides / Q000737:chemistry / Q000302:isolation & purification; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry* / Q000302:isolation & purification; D061065:Polyketides / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D002210:Caprylates; D007306:Insecticides; D010455:Peptides; D061065:Polyketides; C060856:3-ketooctanoic acid