title: Effects of Distilled Cervi Pantotrichum Cornu and Rehmannia glutinosa Pharmacopuncture at GB21 (Jianjing) on Heart Rate Variability: A Randomized and Double-blind Clinical Trial.
abstract: OBJECTIVE
  The purpose of this study was to use heart rate variability (HRV) to investigate the effects of distilled Cervi Pantotrichum Cornu pharmacopuncture and Rehmannia glutinosa pharmacopuncture on the autonomic nervous system.
  
  
  METHODS
  Forty healthy male participants were divided into two groups: the participants of the C-group received distilled Cervi Pantotrichum Cornu pharmacopuncture and those of the R-group received Rehmannia glutinosa pharmacopuncture. The study design was a randomized, double-blind clinical trial. Each participant received one of the two solutions injected at GB21 (Jianjing). The changes in HRV were measured seven times using the QECG-3: LXC3203 system (LAXTHA Inc. Korea). Time-dependent changes in HRV for each group were analyzed using the paired t test (significance level: p < 0.05), and the difference in the HRV fluctuations between the two experimental groups was evaluated using the independent sample test (significance level: p < 0.05).
  
  
  CONCLUSIONS
  The results showed that Cervi Pantotrichum Cornu pharmacopuncture and Rehmannia glutinosa pharmacopuncture tended to activate the autonomic nervous system within the normal range. Cervi Pantotrichum Cornu pharmacopuncture tended to activate the sympathetic nervous system, whereas Rehmannia glutinosa pharmacopuncture tended to activate both the sympathetic and parasympathetic nervous systems.
authors.affiliation: Department of Acupuncture and Moxibustion Medicine, College of Korean Medicine, Woosuk University, Jeonju, South Korea.
authors.forename: Young-Joo
authors.initials: YJ
authors.lastname: Kim
authors.affiliation: Department of Anatomy, College of Korean Medicine, Woosuk University, Jeonju, South Korea.
authors.forename: Chang-Hyun
authors.initials: CH
authors.lastname: Lee
authors.affiliation: Department of Acupuncture and Moxibustion Medicine, College of Korean Medicine, Woosuk University, Jeonju, South Korea.
authors.forename: Jong-Uk
authors.initials: JU
authors.lastname: Kim
authors.affiliation: Department of Acupuncture and Moxibustion Medicine, College of Korean Medicine, Woosuk University, Jeonju, South Korea. Electronic address: nasiss@naver.com.
authors.forename: Tae-Han
authors.initials: TH
authors.lastname: Yook
mesh_terms: D026881:Acupuncture; D015669:Acupuncture Points; D001341:Autonomic Nervous System / Q000187:drug effects* / Q000502:physiology; D029768:Cornus / Q000737:chemistry*; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007267:Injections; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage*; D032267:Rehmannia / Q000737:chemistry*; D056910:Republic of Korea
chemical_list: D010936:Plant Extracts
keywords: Cervi Pantotrichum Cornu; Korean medicine; Rehmannia glutinosa; heart rate variability; pharmacopuncture