title: Accuracy of clinical diagnosis for the identification of potentially malignant disorders and malignant lip lesions.
abstract: The aim of this study was to assess the accuracy of clinical diagnosis for lip lesions based on sensitivity and specificity. The retrospective analysis focused on the detection of lesions caused by potentially malignant disorders (PMDs) and malignant lesions (n = 1195). All cases were classified as benign, PMD, and malignant lesions. Concordance between diagnoses based on clinical examination and those based on histopathological analysis was assessed, and accuracy for the identification of PMD and malignant lesions was calculated. Histopathological analysis revealed 44 lesion types; PMD and malignant lesions comprised 8.3% of all cases. Compared with histopathological analysis, clinical examination showed 97.4% accuracy for the identification of non-malignant and potentially malignant/malignant cases. Degrees of specific sensitivity ranged from 34% to 77% for different lesions, and were highest for autoimmune (77%) and reactive (72%) lesions. Positive and negative predictive values for the identification of PMD and malignant lesions were 81.9% and 98.9%, respectively. Clinical examination showed a high degree of accuracy for the detection of PMD and malignant lip lesions, indicating good reliability.
authors.affiliation: Universidade Federal do Rio Grande do Sul - UFRGS, School of Dentistry, Department of Oral Pathology, Porto Alegre, RS, Brazil.
authors.forename: Marina
authors.initials: M
authors.lastname: Curra
authors.affiliation: University of Oslo, Faculty of Dentistry, Department of Oral Biology, Oslo, Norway.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Salvadori
authors.affiliation: University of Oslo, Faculty of Dentistry, Department of Oral Biology, Oslo, Norway.
authors.forename: Roger
authors.initials: R
authors.lastname: Junges
authors.affiliation: Universidade Federal do Rio Grande do Sul - UFRGS, School of Dentistry, Department of Oral Pathology, Porto Alegre, RS, Brazil.
authors.forename: Manoel Sant'ana
authors.initials: MS
authors.lastname: Filho
authors.affiliation: Universidade Federal do Rio Grande do Sul - UFRGS, School of Dentistry, Center of Community Dental Health Research, Porto Alegre, RS, Brazil.
authors.forename: Fernando Neves
authors.initials: FN
authors.lastname: Hugo
authors.affiliation: Universidade Federal do Rio Grande do Sul - UFRGS, School of Dentistry, Department of Oral Pathology, Porto Alegre, RS, Brazil.
authors.forename: Manoela Domingues
authors.initials: MD
authors.lastname: Martins
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D001938:Brazil / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D003945:Diagnosis, Oral / Q000379:methods; D005260:Female; D006801:Humans; D007223:Infant; D008046:Lip / Q000473:pathology*; D008047:Lip Diseases / Q000453:epidemiology / Q000473:pathology; D008048:Lip Neoplasms / Q000453:epidemiology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D017678:Sex Distribution; D012737:Sex Factors; D055815:Young Adult