title: Stereotactic Body Radiotherapy in Patients with Lung Oligometastases from Colorectal Cancer.
abstract: To assess the role of stereotactic body radiotherapy (SBRT) in pulmonary metastases from colorectal cancer (CRC).
  
  
  
  Thirty-three consecutive patients with pulmonary metastases from CRC who received SBRT were included in the analysis. The primary endpoints were local and systemic progression-free survival, a secondary endpoint was the safety profile of SBRT.
  
  
  
  A total of 56 lesions were treated with SBRT. A single nodule was treated in 15 patients, two in 13 and three in five. The radiotherapy dose and the adopted fractionations were 24-27 Gy as a single fraction for 40 lesions and 27-42 Gy in three fractions (2-3 times a week) for the other 16 lesions. After a median follow-up of 22.8 months (range=1.3-45.7 months), the median progression-free survival of the irradiated sites was 13.4 months.
  
  
  
  SBRT can be considered as local therapy in patients with lung metastases from CRC.
authors.affiliation: Department of Clinical and Translational Sciences, Division of Radiation Oncology, University of Pisa, Pisa, Italy f.pasqualetti@ao-pisa.toscana.it francep24@hotmail.com.
authors.forename: Francesco
authors.initials: F
authors.lastname: Pasqualetti
authors.affiliation: Department of Clinical and Translational Sciences, Division of Radiation Oncology, University of Pisa, Pisa, Italy.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Montrone
authors.affiliation: Department of Clinical and Translational Sciences, Division of Medical Oncology, University of Pisa, Pisa, Italy.
authors.forename: Caterina
authors.initials: C
authors.lastname: Vivaldi
authors.affiliation: Casa di Cura San Rossore, Division of Radiation Oncology, Pisa, Italy.
authors.forename: Margherita
authors.initials: M
authors.lastname: Zani
authors.affiliation: Casa di Cura San Rossore, Division of Radiation Oncology, Pisa, Italy.
authors.forename: David
authors.initials: D
authors.lastname: Fedele
authors.affiliation: Department of Clinical and Translational Sciences, Division of Medical Oncology, University of Pisa, Pisa, Italy.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Fornaro
authors.affiliation: Department of Experimental and Clinical Medicine, Division of Geriatric Unit, University of Pisa, Pisa, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Pasqualetti
authors.affiliation: Department of Clinical and Translational Sciences, Division of Medical Oncology, University of Pisa, Pisa, Italy.
authors.forename: Lisa
authors.initials: L
authors.lastname: Salvatore
authors.affiliation: Department of Clinical and Translational Sciences, Division of Radiation Oncology, University of Pisa, Pisa, Italy.
authors.forename: Bruno
authors.initials: B
authors.lastname: Manfredi
authors.affiliation: Department of Clinical and Translational Sciences, Division of Radiation Oncology, University of Pisa, Pisa, Italy.
authors.forename: Concetta
authors.initials: C
authors.lastname: Laliscia
authors.affiliation: Department of Clinical and Translational Sciences, Division of Radiation Oncology, University of Pisa, Pisa, Italy.
authors.forename: Gabriele
authors.initials: G
authors.lastname: Coraggio
authors.affiliation: Department of Clinical and Translational Sciences, Division of Radiation Oncology, University of Pisa, Pisa, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Gonnelli
authors.affiliation: Department of Clinical and Translational Sciences, Division of Medical Oncology, University of Pisa, Pisa, Italy.
authors.forename: Fotios
authors.initials: F
authors.lastname: Loupakis
authors.affiliation: Department of Clinical and Translational Sciences, Division of Medical Oncology, University of Pisa, Pisa, Italy.
authors.forename: Gianluca
authors.initials: G
authors.lastname: Masi
authors.affiliation: Department of Clinical and Translational Sciences, Division of Radiation Oncology, University of Pisa, Pisa, Italy.
authors.forename: Aldo
authors.initials: A
authors.lastname: Sainato
authors.affiliation: Department of Experimental and Clinical Medicine, Division of Geriatric Unit, University of Pisa, Pisa, Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Monzani
authors.affiliation: Department of Clinical and Translational Sciences, Division of Medical Oncology, University of Pisa, Pisa, Italy.
authors.forename: Alfredo
authors.initials: A
authors.lastname: Falcone
authors.affiliation: Department of Clinical and Translational Sciences, Division of Radiation Oncology, University of Pisa, Pisa, Italy.
authors.forename: Fabiola
authors.initials: F
authors.lastname: Paiar
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000473:pathology*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000532:radiotherapy* / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D016634:Radiosurgery
keywords: Stereotactic body radiotherapy; colorectal cancer; lung metastases; oligometastasic cancer