title: Pallidopenillines: Polyketides from the Alga-Derived Fungus Penicillium thomii Maire KMM 4675.
abstract: Eleven new polyketides, pallidopenillines 1-11, were isolated from the alga-derived fungus Penicillium thomii. The structures of these compounds were established based on spectroscopic methods. The absolute configuration of pallidopenilline A (1) as 4R, 5S, 8S, 9R, 10R, 13R was established using a combination of the modified Mosher's method, X-ray analysis, and NOESY data. The absolute configurations of 2-5 were determined by time-dependent density functional theory calculations of the ECD spectra and ECD and NOESY data. It was shown that 1-acetylpallidopenilline A (2) and pallidopenilline G (10) inhibit the growth of colonies of 22Rv1 cells by 40% at 2 and 1 μM, respectively.
authors.forename: Maria P
authors.initials: MP
authors.lastname: Sobolevskaya
authors.affiliation: Far Eastern Federal University , Suhanova 8, Vladivostok 690950, Russian Federation.
authors.forename: Elena V
authors.initials: EV
authors.lastname: Leshchenko
authors.affiliation: Nha Trang Institute of Technology Research and Application, Vietnam Academy of Science and Technology , Hanoi, Vietnam.
authors.forename: Trinh P T
authors.initials: TP
authors.lastname: Hoai
authors.forename: Vladimir A
authors.initials: VA
authors.lastname: Denisenko
authors.affiliation: Far Eastern Federal University , Suhanova 8, Vladivostok 690950, Russian Federation.|Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumorzentrum, University Medical Center Hamburg-Eppendorf , 20246 Hamburg, Germany.
authors.forename: Sergey A
authors.identifier: http://orcid.org/0000-0002-7155-9245
authors.initials: SA
authors.lastname: Dyshlovoy
authors.forename: Natalya N
authors.initials: NN
authors.lastname: Kirichuk
authors.forename: Yuliya V
authors.initials: YV
authors.lastname: Khudyakova
authors.forename: Natalya Yu
authors.initials: NY
authors.lastname: Kim
authors.forename: Dmitrii V
authors.initials: DV
authors.lastname: Berdyshev
authors.forename: Evgeny A
authors.initials: EA
authors.lastname: Pislyagin
authors.forename: Aleksandra S
authors.initials: AS
authors.lastname: Kuzmich
authors.forename: Andrey V
authors.initials: AV
authors.lastname: Gerasimenko
authors.forename: Roman S
authors.initials: RS
authors.lastname: Popov
authors.affiliation: Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumorzentrum, University Medical Center Hamburg-Eppendorf , 20246 Hamburg, Germany.
authors.forename: Gunhild
authors.initials: G
authors.lastname: von Amsberg
authors.forename: Alexandr S
authors.initials: AS
authors.lastname: Antonov
authors.forename: Shamil Sh
authors.identifier: http://orcid.org/0000-0002-5223-2132
authors.initials: SS
authors.lastname: Afiyatullov
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D045325:HCT116 Cells; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010407:Penicillium / Q000737:chemistry*; D061065:Polyketides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D044647:Sargassum / Q000382:microbiology
chemical_list: D000970:Antineoplastic Agents; D061065:Polyketides