title: Use of pentoxifylline and tocopherol in radiation-induced fibrosis and fibroatrophy.
abstract: Radiation-induced fibrosis in the head and neck is a well-established pathophysiological process after radiotherapy. Recently pentoxifylline and tocopherol have been proposed as treatments to combat the late complications of radiation-induced fibrosis and a way of dealing with osteoradionecrosis. They both have a long history in the management of radiation-induced fibrosis at other anatomical sites. In this paper we review their use in sites other than the head and neck to illustrate the potential benefit that they offer to our patients.
authors.affiliation: Oral Surgery Dept, Floor 23, Guys Dental Hospital, London Bridge, London, SE1 9RT. Electronic address: Vinod.Patel@hotmail.co.uk.
authors.forename: V
authors.initials: V
authors.lastname: Patel
authors.affiliation: Department of Oral and Maxillofacial Surgery, Atrium 3, 3rd Floor, Bermondsey Wing, Guy's Hospital, London, SE1 9RT. Electronic address: Mark.mcgurk@kcl.ac.uk.
authors.forename: M
authors.initials: M
authors.lastname: McGurk
mesh_terms: D000975:Antioxidants / Q000627:therapeutic use*; D001284:Atrophy / Q000188:drug therapy / Q000209:etiology; D005355:Fibrosis / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D010431:Pentoxifylline / Q000627:therapeutic use*; D011832:Radiation Injuries / Q000188:drug therapy* / Q000473:pathology*; D011878:Radiotherapy / Q000009:adverse effects; D024505:Tocopherols / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D024505:Tocopherols; D010431:Pentoxifylline
keywords: Radiation-induced fibrosis; pentoxifylline; tocopherol