title: ARF1 at the crossroads of podosome construction and function.
abstract: Podosomes are actin-based proteolytic microdomains of the plasma membrane found in cells that travel across tissues. In this issue, Rafiq et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201605104) reveal that the small guanosine triphosphatase ARF1, a well-known orchestrator of membrane traffic at the Golgi, regulates podosome formation, maintenance, and function.
authors.affiliation: Centre Cardiothoracique de Bordeaux, U1045, Université de Bordeaux, 33000 Bordeaux, France elisabeth.genot@inserm.fr.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Genot
mesh_terms: D000199:Actins; D002462:Cell Membrane; D006056:Golgi Apparatus; D006801:Humans; D000069261:Podosomes; D021381:Protein Transport
chemical_list: D000199:Actins