title: Comprehensive mechanical characterization of PLA fabric combined with PCL to form a composite structure vascular graft.
abstract: Vascular grafts made by tissue engineering processes are prone to buckling and twisting, which can impede blood flow and lead to collapse of the vessel. These vascular conduits may suffer not only from insufficient tensile strength, but also from vulnerabilities related to compression, torsion, and pulsatile pressurization. Aiming to develop a tissue engineering-inspired blood conduit, composite vascular graft (cVG) prototypes were created by combining a flexible polylactic acid (PLA) knitted fabric with a soft polycaprolactone (PCL) matrix. The graft is to be populated in-situ with cellular migration and proliferation into the device. Comprehensive characterizations probed the relationship between structure and mechanical properties of the different cVG prototypes. The composite grafts exhibited major improvements in mechanical characteristics compared to single-material devices, with particular improvement in compression and torsional resistance. A commercial expanded polytetrafluoroethylene (ePTFE) vascular graft was used as a control against the proposed composite vascular grafts. CVG devices showed high tensile strength, high bursting strength, and improved suture retention. Compression, elastic recovery, and compliance were similar to those for the ePTFE graft.
authors.affiliation: Key Laboratory of Textile Science and Technology of Ministry of Education and College of Textiles, Donghua University, 2999 North Renmin Road, Shanghai 201620, China; Department of Surgery, Laval University and Axe of Regenerative Medicine, Research Center CHU, Quebec, Canada.
authors.forename: Chaojing
authors.initials: C
authors.lastname: Li
authors.affiliation: Key Laboratory of Textile Science and Technology of Ministry of Education and College of Textiles, Donghua University, 2999 North Renmin Road, Shanghai 201620, China.
authors.forename: Fujun
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Engineering, University of Cambridge, Cambridge CB2 1PZ, UK.
authors.forename: Graeham
authors.initials: G
authors.lastname: Douglas
authors.affiliation: Department of Surgery, Laval University and Axe of Regenerative Medicine, Research Center CHU, Quebec, Canada.
authors.forename: Ze
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Surgery, Laval University and Axe of Regenerative Medicine, Research Center CHU, Quebec, Canada.
authors.forename: Robert
authors.initials: R
authors.lastname: Guidoin
authors.affiliation: Key Laboratory of Textile Science and Technology of Ministry of Education and College of Textiles, Donghua University, 2999 North Renmin Road, Shanghai 201620, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Wang
mesh_terms: D001807:Blood Vessel Prosthesis; D003187:Compliance; D008422:Materials Testing; D011091:Polyesters / Q000032:analysis*; D011138:Polytetrafluoroethylene / Q000032:analysis*; D011474:Prosthesis Design; D013718:Tensile Strength; D013784:Textiles / Q000032:analysis*
chemical_list: D011091:Polyesters; C033616:poly(lactide); D011138:Polytetrafluoroethylene
keywords: Mechanical analysis; PCL; PLA; Textile composites; Vascular graft