title: Rhodium-Catalyzed Asymmetric Synthesis of β-Branched Amides.
abstract: A general asymmetric route for the one-step synthesis of chiral β-branched amides is reported through the highly enantioselective isomerization of allylamines, followed by enamine exchange, and subsequent oxidation. The enamine exchange allows for a rapid and modular synthesis of various amides, including challenging β-diaryl and β-cyclic.
authors.affiliation: Department of Chemistry, University of Illinois, Urbana-Champaign, 600 S. Mathews, Urbana, IL, 61821, USA.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Wu
authors.affiliation: Department of Chemistry, University of Illinois, Urbana-Champaign, 600 S. Mathews, Urbana, IL, 61821, USA.
authors.forename: Joshua D
authors.initials: JD
authors.lastname: Laffoon
authors.affiliation: Department of Chemistry, University of Illinois, Urbana-Champaign, 600 S. Mathews, Urbana, IL, 61821, USA.
authors.forename: Trang T
authors.initials: TT
authors.lastname: Nguyen
authors.affiliation: Department of Chemistry, University of Illinois, Urbana-Champaign, 600 S. Mathews, Urbana, IL, 61821, USA.
authors.forename: Jacob D
authors.initials: JD
authors.lastname: McAlpin
authors.affiliation: Department of Chemistry, University of Illinois, Urbana-Champaign, 600 S. Mathews, Urbana, IL, 61821, USA.
authors.forename: Kami L
authors.identifier: 0000-0003-3102-2686
authors.initials: KL
authors.lastname: Hull
keywords: amidation; asymmetric isomerization; β-branched amides