title: Interneuronal mechanisms of hippocampal theta oscillations in a full-scale model of the rodent CA1 circuit.
abstract: The hippocampal theta rhythm plays important roles in information processing; however, the mechanisms of its generation are not well understood. We developed a data-driven, supercomputer-based, full-scale (1:1) model of the rodent CA1 area and studied its interneurons during theta oscillations. Theta rhythm with phase-locked gamma oscillations and phase-preferential discharges of distinct interneuronal types spontaneously emerged from the isolated CA1 circuit without rhythmic inputs. Perturbation experiments identified parvalbumin-expressing interneurons and neurogliaform cells, as well as interneuronal diversity itself, as important factors in theta generation. These simulations reveal new insights into the spatiotemporal organization of the CA1 circuit during theta oscillations.
authors.affiliation: Department of Anatomy and Neurobiology, University of California, Irvine, Irvine, United States.
authors.forename: Marianne J
authors.identifier: 0000-0001-6040-3520
authors.initials: MJ
authors.lastname: Bezaire
authors.affiliation: Department of Anatomy and Neurobiology, University of California, Irvine, Irvine, United States.|Department of Neurosurgery, Stanford University, Stanford, United States.
authors.forename: Ivan
authors.identifier: 0000-0002-8224-8549
authors.initials: I
authors.lastname: Raikov
authors.affiliation: Department of Anatomy and Neurobiology, University of California, Irvine, Irvine, United States.
authors.forename: Kelly
authors.initials: K
authors.lastname: Burk
authors.affiliation: Department of Anatomy and Neurobiology, University of California, Irvine, Irvine, United States.
authors.forename: Dhrumil
authors.initials: D
authors.lastname: Vyas
authors.affiliation: Department of Neurosurgery, Stanford University, Stanford, United States.
authors.forename: Ivan
authors.initials: I
authors.lastname: Soltesz
mesh_terms: D000818:Animals; D056547:CA1 Region, Hippocampal / Q000502:physiology*; D007395:Interneurons / Q000502:physiology; D051379:Mice; D016571:Neural Networks, Computer; D009457:Neuroglia / Q000502:physiology; D051381:Rats; D062211:Spatio-Temporal Analysis; D013826:Theta Rhythm
keywords: computational; computational biology; hippocampus; inhibition; model network; mouse; neuroscience; oscillation; rat; systems biology; theta