title: Interaction between airborne copper exposure and ATP7B polymorphisms on inattentiveness in scholar children.
abstract: Recent research indicates that airborne copper exposure in scholar children negatively affects brain functioning. These effects are likely to be influenced by the efficiency of copper metabolism, which is partly regulated by the ATPase copper transporting beta (ATP7B) gene. We investigated whether indoor and outdoor airborne copper exposure is differentially associated with child inattentiveness depending on genetic variation within the ATP7B gene in 1645 scholar children from the BREATHE project. Outdoor (courtyard) and indoor (classroom) air pollution levels were measured during class hours in each school. Inattentiveness was assessed through a follow-up with four measurements via the Attentional Network Test (4475 observations). Linear mixed models considering repeated measures were conducted to assess genetic and exposure main and interaction effects. Two interactions were detected indicating that ATP7B-rs1061472 (P for interaction 0.016) and ATP7B-rs1801243 (P for interaction 0.003) polymorphisms modified the association between indoor copper exposure and inattentiveness. Stratified analysis by genotypes revealed that both outdoor and indoor copper exposure increased inattentiveness in rs1061472-CC and rs1801243-CC carriers. These findings suggest that the genetic background promotes the association between airborne copper exposure at school with inattentiveness in children.
authors.affiliation: IS Global, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Spain. Electronic address: silvia.alemany@global.org.
authors.forename: S
authors.initials: S
authors.lastname: Alemany
authors.affiliation: IS Global, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Spain.
authors.forename: N
authors.initials: N
authors.lastname: Vilor-Tejedor
authors.affiliation: IS Global, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Spain; Centre for Genomic Regulation (CRG), Barcelona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Bustamante
authors.affiliation: IS Global, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Spain.
authors.forename: M
authors.initials: M
authors.lastname: Álvarez-Pedrerol
authors.affiliation: IS Global, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Spain; Institute for Environmental Assessment and Water Research (IDÆA-CSIC), Barcelona, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Rivas
authors.affiliation: IS Global, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Spain.
authors.forename: J
authors.initials: J
authors.lastname: Forns
authors.affiliation: Institute for Environmental Assessment and Water Research (IDÆA-CSIC), Barcelona, Spain.
authors.forename: X
authors.initials: X
authors.lastname: Querol
authors.affiliation: MRI Research Unit, Department of Radiology, Hospital del Mar and Centro Investigación Biomédica en Red de Salud Mental, CIBERSAM G21, Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Pujol
authors.affiliation: IS Global, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Sunyer
mesh_terms: D000251:Adenosine Triphosphatases / Q000235:genetics*; D000393:Air Pollutants / Q000032:analysis*; D016902:Air Pollution, Indoor / Q000032:analysis; D001288:Attention; D027682:Cation Transport Proteins / Q000235:genetics*; D002648:Child; D003071:Cognition; D003300:Copper / Q000032:analysis*; D000073840:Copper-Transporting ATPases; D004784:Environmental Monitoring; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012574:Schools
chemical_list: D000393:Air Pollutants; D027682:Cation Transport Proteins; D003300:Copper; D000251:Adenosine Triphosphatases; C000612464:ATP7B protein, human; D000073840:Copper-Transporting ATPases
keywords: ATP7B; Copper; Gene-environment interaction; Inattentiveness