title: Regional hyperthermia combined with radiotherapy for esophageal squamous cell carcinoma with supraclavicular lymph node metastasis.
abstract: To assess the efficacy and toxicity of Intensity-modulated radiotherapy (IMRT) and hyperthermia for upper and middle thoracic esophageal squamous cell carcinoma (UMT-ESCC) with supraclavicular lymph node metastasis. A total of 50 patients with UMT-ESCC with supraclavicular lymph node metastasis were evaluated in this retrospective study. All patients received IMRT. Hyperthermia was delivered simultaneously with irradiation, in 45 minutes twice a week for 5-6 weeks. Hyperthermia included supraclavicular lymph node metastasis. Forty-four patients (88.0%) received concurrent chemoradiotherapy based on cisplatin regimens. The most common types of hematological toxicities were anemia (62.0%) and leukopenia (60.0%). Most of these events were grade 1-2 and transient. The 3-year progression-free survival (PFS) rate and overall survival (OS) rate were 34.9% and 42.5%, respectively. Cox regression revealed that tumor length and number of supraclavicular lymph node metastasis were two independent predictors of OS (tumor length: HR=3.65, p=0.008; nodal stage: HR=8.07, p=0.019). The IMRT combined with supraclavicular regional hyperthermia has low toxicity and well tolerated with excellent local control in UMT-ESCC with supraclavicular lymph node metastasis.
authors.affiliation: Department of Radiotherapy, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China.|Key Laboratory Diagnosis and Treatment Technology on Thoracic Oncology, Zhejiang, China.
authors.forename: Liming
authors.initials: L
authors.lastname: Sheng
authors.affiliation: Department of Radiotherapy, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China.|Key Laboratory Diagnosis and Treatment Technology on Thoracic Oncology, Zhejiang, China.
authors.forename: Yongling
authors.initials: Y
authors.lastname: Ji
authors.affiliation: Department of Hyperthermia, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China.
authors.forename: Qiner
authors.initials: Q
authors.lastname: Wu
authors.affiliation: Department of Radiotherapy, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China.|Key Laboratory Diagnosis and Treatment Technology on Thoracic Oncology, Zhejiang, China.
authors.forename: Xianghui
authors.initials: X
authors.lastname: Du
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy / Q000379:methods; D018572:Disease-Free Survival; D004938:Esophageal Neoplasms / Q000473:pathology / Q000628:therapy*; D000077277:Esophageal Squamous Cell Carcinoma; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D011878:Radiotherapy / Q000379:methods*; D012189:Retrospective Studies
keywords: esophageal cancer; prognosis; radiotherapy; regional hyperthermia