title: Elevated Expression of Ox2R in Cervical Cancers and Placentas of Uyghur Women in Xinjiang, China
abstract: Objective:Cervical cancer is one of the major causes of mortality of Uyghur women in Xinjiang, China. Although
  increased expression of orexin receptor (OxR), known to be strongly expressed in human placenta, has a proven
  relation to some cancers , there have been few studies of cervical cancer. Thus, we explored this question by evaluating
  the expression of orexin receptor as a biomarker for screening early stage of cervical cancer in Uyghur women with
  highest occurrence rate of cervical cancer in China. Study Design: We used polymerase chain reaction (PCR) and
  immunohistochemical staining to determine the expression of both Ox1R and Ox2R in cervical cancer and cervicitis
  biopsies collected from Uyghur women infected with human papilloma virus (HPV)16. The expression rate was
  compared between cervical cancers of low, intermediate and high differentiation and cervicitis. Results:Although there
  was no significant difference in the expression rate of Ox1R between groups, Ox2R was significantly overexpressed in
  cervical cancer patients when compared to the cervicitis group. Ox1R was negative in normal human placenta while
  Ox2R was positive. Conclusions: While expression of Ox1R had no correlation with invasion or metastatic potential,
  Ox2R demonstrated elevation in cervical cancer with heterogeneity in groups with different metastatic potential, in
  the human placenta as well, implying that it might serve as an indicator of invasive capacity along with other indices.
authors.affiliation: Seven-year Clinical Medicine of Class 2, year 2011,Xinjiang Medical University, Urumqi, PR China. Email:961058570@qq.com
authors.forename: Reyisha
authors.initials: R
authors.lastname: Taximaimaiti
authors.forename: Xiekelai
authors.initials: X
authors.lastname: Abuliken
authors.forename: Muzhapaer
authors.initials: M
authors.lastname: Maihemuti
authors.forename: Dilinuer
authors.initials: D
authors.lastname: Abudujilile
authors.forename: Haimiti
authors.initials: H
authors.lastname: Abudulimu
keywords: Ox1R; Ox2R; cervical cancer; HPV16; human placenta