title: Decreased Serum 25-hydroxyvitamin D Level Causes Interventricular Septal Hypertrophy in Patients on Peritoneal Dialysis: Cardiovascular Aspects of Endogenous Vitamin D Deficiency.
abstract: Introduction. In the present study, we aimed to analyze the relation of vitamin D with echocardiographic indexes in patients with end stage renal disease (ESRD) receiving renal replacement therapy (RRT).Methods. A total of 98 patients, 64 patients on hemodialysis (HD) (29F/35M, mean age 56.75 ± 18.63 years) and 34 age matched patients on peritoneal dialysis (PD) (21F/13M, mean age 58.11 ± 10.63 years), with similar duration of ESRD and RRT were enrolled into this cross-sectional study. Echocardiographic examination was performed after dialysis session at normovolemic status. Fasting blood samples were obtained before dialysis session.Results. Patients on PD and female patients in both groups had significantly lower level of 25-OH-D3 level when compared to patients on HD or male patients (p: 0.0001 andp: 0.0001). When all participants were considered, there was no significant association between 25-OH-D3 and echocardiographic parameters; however, in patients on PD, a significant negative correlation was determined between 25-OH-D3 and diastolic blood pressure, interventricular septal hypertrophy (ISH), and left ventricular mass index (LVMI) (r: -0.424,p: 0.012;r: -0.508,p: 0.004;r: 0.489,p: 0.04, resp.).Conclusion. Low serum 25-hydroxyvitamin D levels is associated with ISH and LVMI in PD patients.
authors.affiliation: Department of Internal Medicine and Nephrology, Bagcilar Education and Research Hospital, Istanbul, Turkey.
authors.forename: Bennur
authors.identifier: 0000-0002-6003-8970
authors.initials: B
authors.lastname: Esen
authors.affiliation: Department of Cardiology, Bagcilar Education and Research Hospital, Istanbul, Turkey.
authors.forename: Irfan
authors.initials: I
authors.lastname: Sahin
authors.affiliation: Department of Internal Medicine, Bagcilar Education and Research Hospital, Istanbul, Turkey.
authors.forename: Ahmet Engin
authors.identifier: 0000-0002-3711-5157
authors.initials: AE
authors.lastname: Atay
authors.affiliation: Department of Internal Medicine, Bagcilar Education and Research Hospital, Istanbul, Turkey.
authors.forename: Emel
authors.initials: E
authors.lastname: Saglam Gokmen
authors.affiliation: Department of Internal Medicine and Nephrology, Bakırkoy Sadi Konuk Education and Research Hospital, Istanbul, Turkey.
authors.forename: Ozlem
authors.identifier: 0000-0002-0907-1126
authors.initials: O
authors.lastname: Harmankaya Kaptanogullari
authors.affiliation: Department of Internal Medicine and Nephrology, Bakırkoy Sadi Konuk Education and Research Hospital, Istanbul, Turkey.
authors.forename: Mürvet
authors.initials: M
authors.lastname: Yılmaz
authors.affiliation: Department of Biochemistry, Bagcilar Education and Research Hospital, Istanbul, Turkey.
authors.forename: Suat Hayri
authors.initials: SH
authors.lastname: Kucuk
authors.affiliation: Department of Internal Medicine and Nephrology, Sevket Yılmaz Education and Research Hospital, Bursa, Turkey.
authors.forename: Serdar
authors.initials: S
authors.lastname: Kahvecioglu
authors.affiliation: Department of Internal Medicine and Nephrology, Cerrahpasa School of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Nurhan
authors.initials: N
authors.lastname: Seyahi