title: Blonanserin treatment in patients with methamphetamine-induced psychosis comorbid with intellectual disabilities.
abstract: OBJECTIVE
  Methamphetamine (MA) use has recently been associated with high levels of psychiatric hospitalization and serious social dysfunction. MA use causes frequent psychotic symptoms, which can be treated with antipsychotics. However, people with intellectual disabilities (ID) are vulnerable to adverse effects resulting from treatment with antipsychotic medications.
  
  
  METHODS
  We report two cases of MA-induced psychosis (MAP) in patients with ID who were treated with the antipsychotic blonanserin.
  
  
  RESULTS
  In both the cases presented, symptoms of psychosis were improved by switching medications from other antipsychotic drugs to blonanserin. Despite the presence of ID in these patients, no significant adverse effects, such as sedation, were detected after treatment with blonanserin.
  
  
  CONCLUSIONS
  Blonanserin may be an effective and well-tolerated pharmacotherapeutical treatment for patients with MAP comorbid with ID. However, further work is necessary to validate this claim.
authors.affiliation: Department of Psychiatry, Nara Medical University School of Medicine, Kashihara, Japan.
authors.forename: Kosuke
authors.initials: K
authors.lastname: Okazaki
authors.affiliation: Department of Psychiatry, Nara Medical University School of Medicine, Kashihara, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Makinodan
authors.affiliation: Department of Psychiatry, Nara Medical University School of Medicine, Kashihara, Japan.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Yamamuro
authors.affiliation: Department of Psychiatry, Nara Medical University School of Medicine, Kashihara, Japan.
authors.forename: Tomoyo
authors.initials: T
authors.lastname: Takata
authors.affiliation: Department of Psychiatry, Nara Medical University School of Medicine, Kashihara, Japan.
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Kishimoto
keywords: blonanserin; intellectual disabilities; methamphetamine; methamphetamine-induced psychosis