title: One Substrate, Two Modes of C-H Functionalization: A Metal-Controlled Site-Selectivity Switch in C-H Arylation Reactions.
abstract: A unique site-selectivity switch has been achieved in the ruthenium-catalyzed C-H arylation reaction of N-acetyl-1,2-dihydroisoquinolines. This metal-mediated switch is antipodal to the previous report on the palladium-mediated C-4 C-H arylation on the same substrate. Mechanistic details reveal interesting aspects of the reaction pathway, and kinetic studies bring out the difference in the modes of C-H activation adopted by the two catalytic systems.
authors.affiliation: Department of Chemistry, 330, Academic Building II, Indian Institute of Science Education and Research Bhopal , Bhopal-Bypass Road, Bhauri, Bhopal 462066, Madhya Pradesh, India.
authors.forename: Virendra Kumar
authors.initials: VK
authors.lastname: Tiwari
authors.affiliation: Department of Chemistry, 330, Academic Building II, Indian Institute of Science Education and Research Bhopal , Bhopal-Bypass Road, Bhauri, Bhopal 462066, Madhya Pradesh, India.
authors.forename: Neha
authors.initials: N
authors.lastname: Kamal
authors.affiliation: Department of Chemistry, 330, Academic Building II, Indian Institute of Science Education and Research Bhopal , Bhopal-Bypass Road, Bhauri, Bhopal 462066, Madhya Pradesh, India.
authors.forename: Manmohan
authors.identifier: 0000-0003-2592-6726
authors.initials: M
authors.lastname: Kapur