title: Metastatic meningioma presenting as a malignant soft tissue tumour.
abstract: BACKGROUND
  Extracranial metastasis of malignant meningioma to soft tissues is extremely rare and its clinical, radiological and pathological features are not well-characterised.
  
  
  METHODS
  We report a case of a 58 year old man who presented with a mobile mass within the left trapezius muscle. The patient had previously undergone surgery for a right frontal lobe high grade anaplastic meningioma. Histology of the soft tissue lesion showed metastatic anaplastic meningioma with clumps of pleomorphic tumour cells which expressed epithelial membrane antigen, cytokeratin and P63 but were negative for other epithelial and mesenchymal markers. A PET-CT scan revealed additional metastatic lesions in the left pleura, liver and iliac bone.
  
  
  CONCLUSIONS
  Metastatic malignant meningioma can very rarely present as a high grade pleomorphic malignant soft tissue tumour and needs to be distinguished from soft tissue sarcomas and metastatic carcinomas that express epithelial antigens.
authors.affiliation: Department of Radiology, Nuffield Orthopaedic Centre, Windmill Road, Oxford, OX3 7HE UK.
authors.forename: Catherine
authors.initials: C
authors.lastname: McCarthy
authors.affiliation: Department of Neuropathology, Oxford University Hospitals Oxford, Oxford, OX3 9DU UK.
authors.forename: Monika
authors.initials: M
authors.lastname: Hofer
authors.affiliation: Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Nuffield Orthopaedic Centre, University of Oxford, Windmill Road, Oxford, OX3 7HE UK.
authors.forename: Marianna
authors.initials: M
authors.lastname: Vlychou
authors.affiliation: Sarcoma Service, Nuffield Orthopedic Centre, Windmill Road, Oxford, OX3 7HE UK.
authors.forename: Robar
authors.initials: R
authors.lastname: Khundkar
authors.affiliation: Sarcoma Service, Nuffield Orthopedic Centre, Windmill Road, Oxford, OX3 7HE UK.
authors.forename: Paul
authors.initials: P
authors.lastname: Critchley
authors.affiliation: Department of Neurosurgery, Oxford University Hospitals, Oxford, OX3 9DU UK.
authors.forename: Simon
authors.initials: S
authors.lastname: Cudlip
authors.affiliation: Department of Neuropathology, Oxford University Hospitals Oxford, Oxford, OX3 9DU UK.
authors.forename: Olaf
authors.initials: O
authors.lastname: Ansorge
authors.affiliation: Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Nuffield Orthopaedic Centre, University of Oxford, Windmill Road, Oxford, OX3 7HE UK.
authors.forename: Nick A
authors.initials: NA
authors.lastname: Athanasou
keywords: Meningioma anaplastic; Metastasis; Soft tissue; Tumour