title: Joint genome-wide prediction in several populations accounting for randomness of genotypes: A hierarchical Bayes approach. I: Multivariate Gaussian priors for marker effects and derivation of the joint probability mass function of genotypes.
abstract: It is important to consider heterogeneity of marker effects and allelic frequencies in across population genome-wide prediction studies. Moreover, all regression models used in genome-wide prediction overlook randomness of genotypes. In this study, a family of hierarchical Bayesian models to perform across population genome-wide prediction modeling genotypes as random variables and allowing population-specific effects for each marker was developed. Models shared a common structure and differed in the priors used and the assumption about residual variances (homogeneous or heterogeneous). Randomness of genotypes was accounted for by deriving the joint probability mass function of marker genotypes conditional on allelic frequencies and pedigree information. As a consequence, these models incorporated kinship and genotypic information that not only permitted to account for heterogeneity of allelic frequencies, but also to include individuals with missing genotypes at some or all loci without the need for previous imputation. This was possible because the non-observed fraction of the design matrix was treated as an unknown model parameter. For each model, a simpler version ignoring population structure, but still accounting for randomness of genotypes was proposed. Implementation of these models and computation of some criteria for model comparison were illustrated using two simulated datasets. Theoretical and computational issues along with possible applications, extensions and refinements were discussed. Some features of the models developed in this study make them promising for genome-wide prediction, the use of information contained in the probability distribution of genotypes is perhaps the most appealing. Further studies to assess the performance of the models proposed here and also to compare them with conventional models used in genome-wide prediction are needed.
authors.affiliation: Department of Animal Sciences, University of Florida, Gainesville, FL, USA; Department of Statistics, University of Florida, Gainesville, FL, USA. Electronic address: carlosmn@ufl.edu.
authors.forename: Carlos Alberto
authors.initials: CA
authors.lastname: Martínez
authors.affiliation: Department of Statistics, University of Florida, Gainesville, FL, USA.
authors.forename: Kshitij
authors.initials: K
authors.lastname: Khare
authors.affiliation: Department of Computer and Information Science and Engineering, University of Florida, Gainesville, FL, USA.
authors.forename: Arunava
authors.initials: A
authors.lastname: Banerjee
authors.affiliation: Department of Animal Sciences, University of Florida, Gainesville, FL, USA.
authors.forename: Mauricio A
authors.initials: MA
authors.lastname: Elzo
mesh_terms: D001499:Bayes Theorem; D019295:Computational Biology; D003198:Computer Simulation; D005787:Gene Frequency; D055106:Genome-Wide Association Study / Q000379:methods*; D005838:Genotype; D008957:Models, Genetic
keywords: Across population genome-enabled prediction; Bayesian modeling; Distribution of genotypes; Heterogeneous allelic frequencies