title: Association of ARMS2/LOC387715 A69S, CFH Y402H, and CFH I62V polymorphisms with retinal angiomatous proliferation compared with typical age-related macular degeneration: a meta-analysis.
abstract: OBJECTIVE
  To compare the published results of studies on the genotype association of ARMS2/LOC387715 A69S, CFH Y402H, and CFH I62V in cases diagnosed as retinal angiomatous proliferation (RAP) versus neovascular age-related macular degeneration (AMD) or healthy controls.
  
  
  METHODS
  Heterogeneity of studies was evaluated using Cochran's Q test and I-square index. To modify the heterogeneity in the variables, we used random effects model. Meta-analysis was performed using STATA.
  
  
  RESULTS
  Four studies were included with 1076 neovascular AMD patients, 222 RAP cases, and 2276 control subjects. Pooled overall odds ratios for RAP/AMD were 1.15 (95% CI 0.60-2.18) for GT versus GG, 3.52 (95% CI 1.25-9.91) for TT versus GG ARMS2, 0.98 (95% CI 0.22-4.29) for GA versus AA, 1.00 (95% CI 0.25-4.02) for GG versus AA CFHI62V, 0.57 (95% CI 0.35-0.93) for CT versus TT CFH Y402H, and 0.40 (95% CI 0.22-0.74) for CC versus TT CFH Y402H. Regression analysis showed that ARMS2 TT genotype has a statistically significant effect on RAP versus AMD compared to CFH genotypes (P < 0.001).
  
  
  CONCLUSIONS
  This meta-analysis disclosed a stronger effect of ARMS2 genotypes in RAP cases compared with CFH Y402H and I62V genotypes.
authors.affiliation: Ocular Tissue Engineering Research Center, Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Pasdaran Ave, Boustan 9th street, Tehran, Iran. mhbonyadi@yahoo.com.
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Jabbarpoor Bonyadi
authors.affiliation: Department of Biostatistics and Epidemiology, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Yaseri
authors.affiliation: Center of Excellence for Biodiversity, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
authors.forename: Mortaza
authors.initials: M
authors.lastname: Bonyadi
authors.affiliation: Ocular Tissue Engineering Research Center, Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Pasdaran Ave, Boustan 9th street, Tehran, Iran.
authors.forename: Masoud
authors.initials: M
authors.lastname: Soheilian
mesh_terms: D000798:Angiomatosis / Q000235:genetics*; D017242:Complement Factor H / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008268:Macular Degeneration / Q000235:genetics; D011110:Polymorphism, Genetic; D011506:Proteins / Q000235:genetics*; D012164:Retinal Diseases / Q000235:genetics*
chemical_list: C514392:ARMS2 protein, human; D011506:Proteins; D017242:Complement Factor H
keywords: ARMS2/LOC387715 A69S; Age-related macular degeneration (AMD); CFH I62V; CFH Y402H; Mechanism of pathogenesis; Meta-analysis; Retinal angiomatous proliferation (RAP)