title: Small GTPases controlling autophagy-related membrane traffic in yeast and metazoans.
abstract: During macroautophagy, the phagophore-mediated formation of autophagosomes and their subsequent fusion with lysosomes requires extensive transformation of the endomembrane system. Membrane dynamics in eukaryotic cells is regulated by small GTPase proteins including Arfs and Rabs. The small GTPase proteins that regulate autophagic membrane traffic are mostly conserved in yeast and metazoans, but there are also several differences. In this mini-review, we compare the small GTPase network of yeast and metazoan cells that regulates autophagy, and point out the similarities and differences in these organisms.
authors.affiliation: a Hungarian Academy of Sciences , Premium Postdoctorate Research Program , Budapest , Hungary.|b Department of Anatomy , Cell and Developmental Biology, Eotvos Lorand University , Budapest , Hungary.
authors.forename: Szabolcs
authors.identifier: 0000-0003-2139-7740
authors.initials: S
authors.lastname: Takáts
authors.affiliation: b Department of Anatomy , Cell and Developmental Biology, Eotvos Lorand University , Budapest , Hungary.
authors.forename: Attila
authors.identifier: 0000-0003-1811-8595
authors.initials: A
authors.lastname: Boda
authors.affiliation: b Department of Anatomy , Cell and Developmental Biology, Eotvos Lorand University , Budapest , Hungary.
authors.forename: Tamás
authors.initials: T
authors.lastname: Csizmadia
authors.affiliation: b Department of Anatomy , Cell and Developmental Biology, Eotvos Lorand University , Budapest , Hungary.|c Institute of Genetics, Biological Research Centre , Szeged , Hungary.
authors.forename: Gábor
authors.identifier: 0000-0001-8548-8874
authors.initials: G
authors.lastname: Juhász
mesh_terms: D000818:Animals; D001343:Autophagy; D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism*; D020558:GTP Phosphohydrolases / Q000378:metabolism*; D042541:Intracellular Space / Q000378:metabolism; D015003:Yeasts / Q000166:cytology* / Q000201:enzymology* / Q000378:metabolism
chemical_list: D020558:GTP Phosphohydrolases
keywords: Arf; Rab; Rag; TORC1; autolysosome; autophagosome; autophagy; membrane fusion; membrane trafficking