title: Tackling myocardial ischemic injury: the signal transducer and activator of transcription 3 (STAT3) at a good site.
abstract: Myocardial ischemia is one of the main causes of cardiac remodeling and heart failure. As a highly evolutionarily conserved pathway, the signal transducer and activator of transcription 3 (STAT3) signaling controls intercellular communication, signaling transduction and gene transcription. Interestingly, STAT3 signaling has been demonstrated to take part in myocardial ischemia. Furthermore, activation of STAT3 signaling contributes to the protective efficacy of various interventions, including pharmacological and non-pharmacological treatment of myocardial ischemic injury. Areas covered: We first introduce the protective mechanisms of STAT3. We then discuss STAT3 signaling in various cells and the roles of STAT3 in myocardial processes during myocardial ischemia. Finally, the roles of STAT3 in myocardial ischemia and the upstream regulators of STAT3 activation are summarized. Expert opinion: In various animal experiments, STAT3 has been demonstrated to take part in myocardial responses to myocardial ischemic injury and to be activated during various modes of protection against myocardial ischemia and ischemia/reperfusion (I/R) injury. However, further clinical evidence on the role of STAT3 in such protection is needed. Treatments targeting STAT3 as a means of reducing myocardial ischemic injury need to be tested in a clinical setting. Furthermore, biotechnology can be used to develop effective drugs for this purpose.
authors.affiliation: a Department of Biomedical Engineering , The Fourth Military Medical University , Xi'an , China.|b Department of Thoracic and Cardiovascular Surgery , Affiliated Drum Tower Hospital of Nanjing University Medical School , Nanjing , Jiangsu , China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.affiliation: a Department of Biomedical Engineering , The Fourth Military Medical University , Xi'an , China.
authors.forename: Wei
authors.initials: W
authors.lastname: Hu
authors.affiliation: c Department of Thoracic Surgery , Tangdu Hospital, The Fourth Military Medical University , Xi'an , China.
authors.forename: Shouyin
authors.initials: S
authors.lastname: Di
authors.affiliation: c Department of Thoracic Surgery , Tangdu Hospital, The Fourth Military Medical University , Xi'an , China.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Ma
authors.affiliation: c Department of Thoracic Surgery , Tangdu Hospital, The Fourth Military Medical University , Xi'an , China.
authors.forename: Chongxi
authors.initials: C
authors.lastname: Fan
authors.affiliation: b Department of Thoracic and Cardiovascular Surgery , Affiliated Drum Tower Hospital of Nanjing University Medical School , Nanjing , Jiangsu , China.
authors.forename: Dongjin
authors.initials: D
authors.lastname: Wang
authors.affiliation: d Department of Aerospace Medicine , The Fourth Military Medical University , Xi'an , China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Jiang
authors.affiliation: a Department of Biomedical Engineering , The Fourth Military Medical University , Xi'an , China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Li
authors.affiliation: b Department of Thoracic and Cardiovascular Surgery , Affiliated Drum Tower Hospital of Nanjing University Medical School , Nanjing , Jiangsu , China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhou
authors.affiliation: a Department of Biomedical Engineering , The Fourth Military Medical University , Xi'an , China.
authors.forename: Tian
authors.initials: T
authors.lastname: Li
authors.affiliation: a Department of Biomedical Engineering , The Fourth Military Medical University , Xi'an , China.
authors.forename: Erping
authors.initials: E
authors.lastname: Luo
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D015195:Drug Design; D006801:Humans; D017202:Myocardial Ischemia / Q000150:complications / Q000473:pathology* / Q000628:therapy; D015428:Myocardial Reperfusion Injury / Q000150:complications / Q000503:physiopathology* / Q000628:therapy; D050796:STAT3 Transcription Factor / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D050796:STAT3 Transcription Factor
keywords: Myocardial ischemia; cardioprotection; non-pharmacological treatment; pharmacological treatment; signal transducer and activator of transcription 3