title: Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis.
abstract: Genome-wide association studies (GWASs) have identified loci for erythrocyte traits in primarily European ancestry populations. We conducted GWAS meta-analyses of six erythrocyte traits in 71,638 individuals from European, East Asian, and African ancestries using a Bayesian approach to account for heterogeneity in allelic effects and variation in the structure of linkage disequilibrium between ethnicities. We identified seven loci for erythrocyte traits including a locus (RBPMS/GTF2E2) associated with mean corpuscular hemoglobin and mean corpuscular volume. Statistical fine-mapping at this locus pointed to RBPMS at this locus and excluded nearby GTF2E2. Using zebrafish morpholino to evaluate loss of function, we observed a strong in vivo erythropoietic effect for RBPMS but not for GTF2E2, supporting the statistical fine-mapping at this locus and demonstrating that RBPMS is a regulator of erythropoiesis. Our findings show the utility of trans-ethnic GWASs for discovery and characterization of genetic loci influencing hematologic traits.
authors.affiliation: Department of Epidemiology, Erasmus MC, 3000 CA Rotterdam, the Netherlands.
authors.forename: Frank J A
authors.initials: FJA
authors.lastname: van Rooij
authors.affiliation: GeneSTAR Research Program, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
authors.forename: Rehan
authors.initials: R
authors.lastname: Qayyum
authors.affiliation: Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland; Icelandic Heart Association, 210 Kopavogur, Iceland.
authors.forename: Albert V
authors.initials: AV
authors.lastname: Smith
authors.affiliation: Harvard Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Stem Cell Program and Division of Hematology/Oncology, Children's Hospital Boston, Pediatric Hematology/Oncology at DFCI, Harvard Stem Cell Institute, Harvard Medical School and Howard Hughes Medical Institute, Boston, MA 02115, USA.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of Cardiology, Leiden University Medical Center, 2300 AC Leiden, the Netherlands; Department of Gerontology and Geriatrics, Leiden University Medical Center, 2300 AC Leiden, the Netherlands.
authors.forename: Stella
authors.initials: S
authors.lastname: Trompet
authors.affiliation: National Institute on Aging, NIH, Baltimore, MD 21224, USA.
authors.forename: Toshiko
authors.initials: T
authors.lastname: Tanaka
authors.affiliation: Laboratory of Neurogenetics, National Institute on Aging, NIH, Bethesda, MD 20892, USA.
authors.forename: Margaux F
authors.initials: MF
authors.lastname: Keller
authors.affiliation: Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan.
authors.forename: Li-Ching
authors.initials: LC
authors.lastname: Chang
authors.affiliation: Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, 8010 Graz, Austria.
authors.forename: Helena
authors.initials: H
authors.lastname: Schmidt
authors.affiliation: Division of Cardiovascular Medicine, Department of Internal Medicine, Department of Human Genetics, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, USA.
authors.forename: Min-Lee
authors.initials: ML
authors.lastname: Yang
authors.affiliation: Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA; Framingham Heart Study, Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, NIH, Framingham, MA 01702, USA.
authors.forename: Ming-Huei
authors.initials: MH
authors.lastname: Chen
authors.affiliation: Icahn Institute for Multiscale Biology, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
authors.forename: James
authors.initials: J
authors.lastname: Hayes
authors.affiliation: Framingham Heart Study, Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, NIH, Framingham, MA 01702, USA.
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Johnson
authors.affiliation: GeneSTAR Research Program, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
authors.forename: Lisa R
authors.initials: LR
authors.lastname: Yanek
authors.affiliation: Department of General and Interventional Cardiology, University Heart Centre Hamburg-Eppendorf, 20246 Hamburg, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Hamburg, Lübeck, Kiel, Hamburg 20246, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Mueller
authors.affiliation: Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.
authors.forename: Leslie
authors.initials: L
authors.lastname: Lange
authors.affiliation: Department of Medicine, University of Washington, Seattle, WA 98195-6420, USA.
authors.forename: James S
authors.initials: JS
authors.lastname: Floyd
authors.affiliation: Department of Epidemiology, Erasmus MC, 3000 CA Rotterdam, the Netherlands; Department of Genetics, School of Medicine, Mashhad University of Medical Sciences, 91375-345 Mashhad, Iran.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Ghanbari
authors.affiliation: National Institute on Aging, NIH, Bethesda, MD 20892-9205, USA.
authors.forename: Alan B
authors.initials: AB
authors.lastname: Zonderman
authors.affiliation: Department of Cardiology, Leiden University Medical Center, 2300 AC Leiden, the Netherlands.
authors.forename: J Wouter
authors.initials: JW
authors.lastname: Jukema
authors.affiliation: Department of Epidemiology, Erasmus MC, 3000 CA Rotterdam, the Netherlands; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
authors.forename: Albert
authors.initials: A
authors.lastname: Hofman
authors.affiliation: Department of Epidemiology, Erasmus MC, 3000 CA Rotterdam, the Netherlands.
authors.forename: Cornelia M
authors.initials: CM
authors.lastname: van Duijn
authors.affiliation: University of Michigan Medical School, Ann Arbor, MI 48109, USA.
authors.forename: Karl C
authors.initials: KC
authors.lastname: Desch
authors.affiliation: Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, 8010 Graz, Austria.
authors.forename: Yasaman
authors.initials: Y
authors.lastname: Saba
authors.affiliation: University of Michigan Medical School, Ann Arbor, MI 48109, USA.
authors.forename: Ayse B
authors.initials: AB
authors.lastname: Ozel
authors.affiliation: Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27101, USA.
authors.forename: Beverly M
authors.initials: BM
authors.lastname: Snively
authors.affiliation: Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan; School of Chinese Medicine, China Medical University, Taichung 40402, Taiwan.
authors.forename: Jer-Yuarn
authors.initials: JY
authors.lastname: Wu
authors.affiliation: Clinical Division of Neurogeriatrics, Department of Neurology, Medical University Graz, 8010 Graz, Austria.
authors.forename: Reinhold
authors.initials: R
authors.lastname: Schmidt
authors.affiliation: Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
authors.forename: Myriam
authors.initials: M
authors.lastname: Fornage
authors.affiliation: Icahn Institute for Multiscale Biology, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Klein
authors.affiliation: Framingham Heart Study, Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, NIH, Framingham, MA 01702, USA.
authors.forename: Caroline S
authors.initials: CS
authors.lastname: Fox
authors.affiliation: Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Matsuda
authors.affiliation: Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Kamatani
authors.affiliation: Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, 55131 Mainz, Germany; German Center for Cardiovascular Research (DZHK), Partner Site RhineMain, Mainz, Germany; Preventive Cardiology and Preventive Medicine, Center for Cardiology, University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, Germany.
authors.forename: Philipp S
authors.initials: PS
authors.lastname: Wild
authors.affiliation: Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow G12 8QQ, UK.
authors.forename: David J
authors.initials: DJ
authors.lastname: Stott
authors.affiliation: Robertson Center for Biostatistics, University of Glasgow, Glasgow G12 8QQ, UK.
authors.forename: Ian
authors.initials: I
authors.lastname: Ford
authors.affiliation: Department of Medical Statistics and Bioinformatics, Section of Molecular Epidemiology, Leiden University Medical Center, 2300 AC Leiden, the Netherlands.
authors.forename: P Eline
authors.initials: PE
authors.lastname: Slagboom
authors.affiliation: Quantitative Sciences Unit, School of Medicine, Stanford University, Stanford, CA 94304, USA.
authors.forename: Jaden
authors.initials: J
authors.lastname: Yang
authors.affiliation: Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215, USA.
authors.forename: Audrey Y
authors.initials: AY
authors.lastname: Chu
authors.affiliation: The Jackson Laboratory, Bar Harbor, ME 04609, USA.
authors.forename: Amy J
authors.initials: AJ
authors.lastname: Lambert
authors.affiliation: Department of Epidemiology, Erasmus MC, 3000 CA Rotterdam, the Netherlands; Department of Internal Medicine, Erasmus MC, 3000 CA Rotterdam, the Netherlands.
authors.forename: André G
authors.initials: AG
authors.lastname: Uitterlinden
authors.affiliation: Department of Epidemiology, Erasmus MC, 3000 CA Rotterdam, the Netherlands.
authors.forename: Oscar H
authors.initials: OH
authors.lastname: Franco
authors.affiliation: Clinical Division of Neurogeriatrics, Department of Neurology, Medical University Graz, 8010 Graz, Austria; Institute of Medical Informatics, Statistics and Documentation, Medical University Graz, 8010 Graz, Austria.
authors.forename: Edith
authors.initials: E
authors.lastname: Hofer
authors.affiliation: University of Michigan Medical School, Ann Arbor, MI 48109, USA.
authors.forename: David
authors.initials: D
authors.lastname: Ginsburg
authors.affiliation: Harvard Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Stem Cell Program and Division of Hematology/Oncology, Children's Hospital Boston, Pediatric Hematology/Oncology at DFCI, Harvard Stem Cell Institute, Harvard Medical School and Howard Hughes Medical Institute, Boston, MA 02115, USA.
authors.forename: Bella
authors.initials: B
authors.lastname: Hu
authors.affiliation: Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pediatrics, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Brendan
authors.initials: B
authors.lastname: Keating
authors.affiliation: Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
authors.forename: Ursula M
authors.initials: UM
authors.lastname: Schick
authors.affiliation: Department of Medicine, University of Washington, Seattle, WA 98195-6420, USA.
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Brody
authors.affiliation: University of Michigan Medical School, Ann Arbor, MI 48109, USA.
authors.forename: Jun Z
authors.initials: JZ
authors.lastname: Li
authors.affiliation: Department of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ 85724, USA.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of General and Interventional Cardiology, University Heart Centre Hamburg-Eppendorf, 20246 Hamburg, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Hamburg, Lübeck, Kiel, Hamburg 20246, Germany.
authors.forename: Tanja
authors.initials: T
authors.lastname: Zeller
authors.affiliation: Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
authors.forename: Jack M
authors.initials: JM
authors.lastname: Guralnik
authors.affiliation: Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215, USA; Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Daniel I
authors.initials: DI
authors.lastname: Chasman
authors.affiliation: The Jackson Laboratory, Bar Harbor, ME 04609, USA.
authors.forename: Luanne L
authors.initials: LL
authors.lastname: Peters
authors.affiliation: Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.
authors.forename: Michiaki
authors.initials: M
authors.lastname: Kubo
authors.affiliation: GeneSTAR Research Program, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
authors.forename: Diane M
authors.initials: DM
authors.lastname: Becker
authors.affiliation: Cardiovascular Medicine Division, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94304, USA.
authors.forename: Jin
authors.initials: J
authors.lastname: Li
authors.affiliation: Icelandic Heart Association, 210 Kopavogur, Iceland.
authors.forename: Gudny
authors.initials: G
authors.lastname: Eiriksdottir
authors.affiliation: Institute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, LABioMed at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
authors.forename: Jerome I
authors.initials: JI
authors.lastname: Rotter
authors.affiliation: Framingham Heart Study, Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, NIH, Framingham, MA 01702, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Levy
authors.affiliation: Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, 55131 Mainz, Germany.
authors.forename: Vera
authors.initials: V
authors.lastname: Grossmann
authors.affiliation: National Institute on Aging, NIH, Bethesda, MD 20892-9205, USA.
authors.forename: Kushang V
authors.initials: KV
authors.lastname: Patel
authors.affiliation: Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan; School of Chinese Medicine, China Medical University, Taichung 40402, Taiwan.
authors.forename: Chien-Hsiun
authors.initials: CH
authors.lastname: Chen
authors.affiliation: Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215, USA; Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Paul M
authors.initials: PM
authors.lastname: Ridker
authors.affiliation: Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
authors.forename: Hua
authors.initials: H
authors.lastname: Tang
authors.affiliation: Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Intramural Research Program, NIH, Bethesda, MD 20892-9205, USA.
authors.forename: Lenore J
authors.initials: LJ
authors.lastname: Launer
authors.affiliation: Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.
authors.forename: Kenneth M
authors.initials: KM
authors.lastname: Rice
authors.affiliation: Department of Clinical Epidemiology, Leiden University Medical Center, Leiden 2300 AC, the Netherlands.
authors.forename: Ruifang
authors.initials: R
authors.lastname: Li-Gao
authors.affiliation: National Institute on Aging, NIH, Baltimore, MD 21224, USA.
authors.forename: Luigi
authors.initials: L
authors.lastname: Ferrucci
authors.affiliation: Health Disparities Research Section, Clinical Research Branch, National Institute on Aging, NIH, Baltimore, MD 20892, USA.
authors.forename: Michelle K
authors.initials: MK
authors.lastname: Evans
authors.affiliation: Harvard Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Stem Cell Program and Division of Hematology/Oncology, Children's Hospital Boston, Pediatric Hematology/Oncology at DFCI, Harvard Stem Cell Institute, Harvard Medical School and Howard Hughes Medical Institute, Boston, MA 02115, USA.
authors.forename: Avik
authors.initials: A
authors.lastname: Choudhuri
authors.affiliation: Stem Cell Program and Division of Hematology/Oncology, Children's Hospital Boston, Pediatric Hematology/Oncology at DFCI, Harvard Stem Cell Institute, Harvard Medical School and Howard Hughes Medical Institute, Boston, MA 02115, USA; Max Planck Institute of Immunobiology and Epigenetics, Freiburg 79108, Germany.
authors.forename: Eirini
authors.initials: E
authors.lastname: Trompouki
authors.affiliation: Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Abraham
authors.affiliation: Harvard Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Stem Cell Program and Division of Hematology/Oncology, Children's Hospital Boston, Pediatric Hematology/Oncology at DFCI, Harvard Stem Cell Institute, Harvard Medical School and Howard Hughes Medical Institute, Boston, MA 02115, USA.
authors.forename: Song
authors.initials: S
authors.lastname: Yang
authors.affiliation: Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takahashi
authors.affiliation: Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.
authors.forename: Yoichiro
authors.initials: Y
authors.lastname: Kamatani
authors.affiliation: Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
authors.forename: Charles
authors.initials: C
authors.lastname: Kooperberg
authors.affiliation: Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Intramural Research Program, NIH, Bethesda, MD 20892-9205, USA.
authors.forename: Tamara B
authors.initials: TB
authors.lastname: Harris
authors.affiliation: Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul 03722, Korea.
authors.forename: Sun Ha
authors.initials: SH
authors.lastname: Jee
authors.affiliation: Johns Hopkins Bloomberg School of Public Health, George W. Comstock Center for Public Health Research and Prevention, Comstock Center & Cardiovascular Epidemiology, Welch Center for Prevention, Epidemiology and Clinical Research, Baltimore, MD 21205, USA.
authors.forename: Josef
authors.initials: J
authors.lastname: Coresh
authors.affiliation: School of Chinese Medicine, China Medical University, Taichung 40402, Taiwan.
authors.forename: Fuu-Jen
authors.initials: FJ
authors.lastname: Tsai
authors.affiliation: Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21225, USA.
authors.forename: Dan L
authors.initials: DL
authors.lastname: Longo
authors.affiliation: Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan.
authors.forename: Yuan-Tsong
authors.initials: YT
authors.lastname: Chen
authors.affiliation: Department of Epidemiology, Erasmus MC, 3000 CA Rotterdam, the Netherlands.
authors.forename: Janine F
authors.initials: JF
authors.lastname: Felix
authors.affiliation: Framingham Heart Study, Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, NIH, Framingham, MA 01702, USA; Department of Biostatistics, Boston University of Public Health, Boston, MA 02118, USA.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Yang
authors.affiliation: Departments of Epidemiology, Health Services, and Medicine, University of Washington, Seattle, WA 98195, USA; Group Health Research Institute, Group Health Cooperative, Seattle, WA 98101, USA.
authors.forename: Bruce M
authors.initials: BM
authors.lastname: Psaty
authors.affiliation: Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
authors.forename: Eric
authors.initials: E
authors.lastname: Boerwinkle
authors.affiliation: GeneSTAR Research Program, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
authors.forename: Lewis C
authors.initials: LC
authors.lastname: Becker
authors.affiliation: Department of Clinical Epidemiology, Leiden University Medical Center, Leiden 2300 AC, the Netherlands; Department of BESC, Epidemiology Section, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia; Department of Public Health and Primary Care, Leiden University Medical Center, 2300 AC Leiden, the Netherlands.
authors.forename: Dennis O
authors.initials: DO
authors.lastname: Mook-Kanamori
authors.affiliation: Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, USA.
authors.forename: James G
authors.initials: JG
authors.lastname: Wilson
authors.affiliation: Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland; Icelandic Heart Association, 210 Kopavogur, Iceland.
authors.forename: Vilmundur
authors.initials: V
authors.lastname: Gudnason
authors.affiliation: Framingham Heart Study, Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, NIH, Framingham, MA 01702, USA.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: O'Donnell
authors.affiliation: Department of Epidemiology, Erasmus MC, 3000 CA Rotterdam, the Netherlands; Department of Biostatistics and Epidemiology, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College, W2 1PG London, UK.
authors.forename: Abbas
authors.initials: A
authors.lastname: Dehghan
authors.affiliation: Framingham Heart Study, Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, NIH, Framingham, MA 01702, USA; Department of Biostatistics, Boston University of Public Health, Boston, MA 02118, USA.
authors.forename: L Adrienne
authors.initials: LA
authors.lastname: Cupples
authors.affiliation: Laboratory of Neurogenetics, National Institute on Aging, NIH, Bethesda, MD 20892, USA.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Nalls
authors.affiliation: Department of Biostatistics, University of Liverpool, Block F, Waterhouse Building, 1-5 Brownlow Street, Liverpool L69 3GL, UK; Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Morris
authors.affiliation: Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.
authors.forename: Yukinori
authors.initials: Y
authors.lastname: Okada
authors.affiliation: Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Department of Epidemiology, University of Washington, Seattle, WA 98195, USA.
authors.forename: Alexander P
authors.initials: AP
authors.lastname: Reiner
authors.affiliation: Harvard Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Stem Cell Program and Division of Hematology/Oncology, Children's Hospital Boston, Pediatric Hematology/Oncology at DFCI, Harvard Stem Cell Institute, Harvard Medical School and Howard Hughes Medical Institute, Boston, MA 02115, USA.
authors.forename: Leonard I
authors.initials: LI
authors.lastname: Zon
authors.affiliation: Division of Cardiovascular Medicine, Department of Internal Medicine, Department of Human Genetics, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, USA. Electronic address: sganesh@umich.edu.
authors.forename: Santhi K
authors.initials: SK
authors.lastname: Ganesh
mesh_terms: D000349:Africa / Q000208:ethnology; D000483:Alleles; D000818:Animals; D001499:Bayes Theorem; D004912:Erythrocytes / Q000378:metabolism*; D004920:Erythropoiesis / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics; D005060:Europe / Q000208:ethnology; D005202:Asia, Eastern / Q000208:ethnology; D005260:Female; D055106:Genome-Wide Association Study; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D016601:RNA-Binding Proteins / Q000235:genetics*; D044469:Racial Groups / Q000235:genetics*; D015027:Zebrafish / Q000235:genetics
chemical_list: C101827:RBPMS protein, human; D016601:RNA-Binding Proteins