title: Influence of Monovalent Cation Size on Nanodomain Formation in Anionic-Zwitterionic Mixed Bilayers.
abstract: Phosphatidylserine (PS) and phosphatidylcholine (PC) are two of the major anionic and zwitterionic phospholipids in mammalian cell membranes. Ion-PS interaction is hypothesized to play a crucial role in a range of biological events including membrane fusion, lipid phase modulation, membrane protein insertion and translocation. In this study, we characterize lipid nanodomain formation in PC/PS mixed bilayers using coarse-grained simulations. We investigate the role of monovalent cation sizes in modulating lipid-ion binding modes and lipid demixing. Our simulations suggest that certain lipid-ion binding modes lead to growth of ion-mediated PS lipid clusters. The existing literature reveals the polymorphism in binding and partitioning patterns in monovalent cations (Na+, K+, and Li+) with anionic lipids. Our work provides a microscopic view on the ion-size-dependent PS lipid packing pattern observed experimentally. A coupled relationship between lipid curvature and asymmetry is observed in highly demixed PC/PS mixed bilayers.
authors.affiliation: Fischell Department of Bioengineering and ‡Biophysics Program, Institute of Physical Science and Technology, University of Maryland , College Park, Maryland 20742, United States.
authors.forename: Sai J
authors.initials: SJ
authors.lastname: Ganesan
authors.affiliation: Fischell Department of Bioengineering and ‡Biophysics Program, Institute of Physical Science and Technology, University of Maryland , College Park, Maryland 20742, United States.
authors.forename: Hongcheng
authors.initials: H
authors.lastname: Xu
authors.affiliation: Fischell Department of Bioengineering and ‡Biophysics Program, Institute of Physical Science and Technology, University of Maryland , College Park, Maryland 20742, United States.
authors.forename: Silvina
authors.identifier: 0000-0003-3824-9787
authors.initials: S
authors.lastname: Matysiak
mesh_terms: D000838:Anions / Q000737:chemistry; D002412:Cations / Q000737:chemistry; D008051:Lipid Bilayers / Q000737:chemistry*; D019565:Metals, Light / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D010713:Phosphatidylcholines / Q000737:chemistry*; D010718:Phosphatidylserines / Q000737:chemistry*; D010743:Phospholipids / Q000737:chemistry*
chemical_list: D000838:Anions; D002412:Cations; D008051:Lipid Bilayers; D019565:Metals, Light; D010713:Phosphatidylcholines; D010718:Phosphatidylserines; D010743:Phospholipids