title: Refinements of nerve repair with connector-assisted coaptation.
abstract: Peripheral nerve repair can be very rewarding for both surgeon and patient when expected outcomes are achieved. In many cases, however, the results are suboptimal due to number of possible objective and technical reasons. Although we cannot influence patent's comorbidities, the extent or mechanism of the nerve injury, we may help optimize technical details when aiming towards improved outcomes. While the suture coaptation for primary nerve repair or nerve reconstruction with grafting served as the reconstructive standard for many decades, technical imperfections remain threats to reconstructive goals. Tension, fascicular misalignment generated by over tightening suture coaptation, deeply placed sutures, reactive scarring to foreign material at anastomosis site, may all negatively affect axonal regeneration. As the goal of every nerve repair is to have ideally opposed tension free nerve fascicles, protected from the deleterious effects of the wound bed. The utilization of coaptation aids to overcome the challenges of nerve repair has been suggested as an alternative to the classical suture repair. A review of clinical literature was performed to assess the evidence for this technique and the critical success factors to consider when implementing this technique. Twelve clinical studies met criteria, majority suggesting improved outcomes by the utilization of a coaptation aid. Most commonly reported improvements were improved sensory outcomes, reduced tenderness or pain at the coaptation site and reduced operative time. The current clinical evidence data suggests that utilization of a coaptation aid is a technical innovation to help provide better nerve repair and reconstructive functional outcomes.
authors.affiliation: Washinton Nerve Institute, McLean, Virginia.
authors.forename: Ivica
authors.initials: I
authors.lastname: Ducic
authors.affiliation: The Buncke Clinic, San Francisco, California.
authors.forename: Bauback
authors.initials: B
authors.lastname: Safa
authors.affiliation: AxoGen, Inc, Alachua, Florida.
authors.forename: Erick
authors.initials: E
authors.lastname: DeVinney
mesh_terms: D000714:Anastomosis, Surgical / Q000379:methods; D000818:Animals; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009416:Nerve Regeneration / Q000502:physiology*; D019635:Neurosurgical Procedures / Q000295:instrumentation* / Q000379:methods; D059348:Peripheral Nerve Injuries / Q000175:diagnosis / Q000601:surgery*; D010525:Peripheral Nerves / Q000601:surgery; D019736:Prostheses and Implants; D020127:Recovery of Function; D013536:Suture Techniques; D016896:Treatment Outcome