title: Non-Coding RNAs in Lung Cancer: Contribution of Bioinformatics Analysis to the Development of Non-Invasive Diagnostic Tools.
abstract: Lung cancer is currently the leading cause of cancer related mortality due to late diagnosis and limited treatment intervention. Non-coding RNAs are not translated into proteins and have emerged as fundamental regulators of gene expression. Recent studies reported that microRNAs and long non-coding RNAs are involved in lung cancer development and progression. Moreover, they appear as new promising non-invasive biomarkers for early lung cancer diagnosis. Here, we highlight their potential as biomarker in lung cancer and present how bioinformatics can contribute to the development of non-invasive diagnostic tools. For this, we discuss several bioinformatics algorithms and software tools for a comprehensive understanding and functional characterization of microRNAs and long non-coding RNAs.
authors.affiliation: Functional Genomics and Systems Biology Group, Department of Bioinformatics, Biocenter, University of Wuerzburg, 97074 Wuerzburg, Germany. meik.kunz@uni-wuerzburg.de.
authors.forename: Meik
authors.initials: M
authors.lastname: Kunz
authors.affiliation: Functional Genomics and Systems Biology Group, Department of Bioinformatics, Biocenter, University of Wuerzburg, 97074 Wuerzburg, Germany. beat.wolf@hefr.ch.|University of Applied Sciences and Arts of Western Switzerland, Perolles 80, 1700 Fribourg, Switzerland. beat.wolf@hefr.ch.
authors.forename: Beat
authors.initials: B
authors.lastname: Wolf
authors.affiliation: Institute of Experimental Biomedicine, University Hospital Wuerzburg, 97080 Wuerzburg, Germany. schulze_h@ukw.de.
authors.forename: Harald
authors.initials: H
authors.lastname: Schulze
authors.affiliation: Phenosystems SA, 137 Rue de Tubize, 1440 Braine le Château, Belgium. phenosystems@gmail.com.
authors.forename: David
authors.initials: D
authors.lastname: Atlan
authors.affiliation: Department of Cardiothoracic Surgery, University Hospital of Wuerzburg, 97080 Wuerzburg, Germany. walles_t@ukw.de.
authors.forename: Thorsten
authors.initials: T
authors.lastname: Walles
authors.affiliation: Department of Tissue Engineering and Regenerative Medicine, University Hospital Wuerzburg, Roentgenring 11, 97070 Wuerzburg, Germany. heike.walles@igb.fraunhofer.de.|Translational Center Wuerzburg "Regenerative therapies in oncology and musculoskeletal disease" Wuerzburg branch of the Fraunhofer Institute Interfacial Engineering and Biotechnology (IGB), Roentgenring 11, 97070 Wuerzburg, Germany. heike.walles@igb.fraunhofer.de.
authors.forename: Heike
authors.initials: H
authors.lastname: Walles
authors.affiliation: Functional Genomics and Systems Biology Group, Department of Bioinformatics, Biocenter, University of Wuerzburg, 97074 Wuerzburg, Germany. dandekar@biozentrum.uni-wuerzburg.de.|BioComputing Unit, European Molecular Biology Laboratory (EMBL) Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany. dandekar@biozentrum.uni-wuerzburg.de.
authors.forename: Thomas
authors.initials: T
authors.lastname: Dandekar
keywords: algorithm; bioinformatics; early diagnosis; lncRNAs; lung cancer; miRNAs; non-invasive biomarkers