title: Dengue Virus-Specific Antibodies Enhance Brazilian Zika Virus Infection.
abstract: Anti-Flavivirus antibodies are highly cross-reactive and may facilitate Zika virus (ZIKV) infection through the antibody-dependent enhancement (ADE) mechanism. We demonstrate that dengue-specific antibodies enhance the infection of a primary Brazilian ZIKV isolate in a FcγRII-expressing K562 cell line. In addition, we demonstrate that serum samples from dengue-immune pregnant women enhanced ZIKV infection. These findings highlight the need for epidemiological studies and animal models to further confirm the role of ADE in the development of congenital and neurological complications associated with ZIKV infections.
authors.affiliation: Aggeu Magalhães Research Center, Oswaldo Cruz Foundation (FIOCRUZ), Recife, Brazil.|Faculty of Medical Science/ Institute of Biological Science, University of Pernambuco, Recife, Brazil.
authors.forename: Priscila M S
authors.initials: PMS
authors.lastname: Castanha
authors.affiliation: Center for Vaccine Research, University of Pittsburgh, Pennsylvania, USA.|Department of Infectious Disease and Microbiology, University of Pittsburgh, Pennsylvania, USA.
authors.forename: Eduardo J M
authors.initials: EJM
authors.lastname: Nascimento
authors.affiliation: Aggeu Magalhães Research Center, Oswaldo Cruz Foundation (FIOCRUZ), Recife, Brazil.|Instituto de Medicina Integral Prof. Fernando Figueira, Recife, Brazil.
authors.forename: Cynthia
authors.initials: C
authors.lastname: Braga
authors.affiliation: Aggeu Magalhães Research Center, Oswaldo Cruz Foundation (FIOCRUZ), Recife, Brazil.
authors.forename: Marli T
authors.initials: MT
authors.lastname: Cordeiro
authors.affiliation: Aggeu Magalhães Research Center, Oswaldo Cruz Foundation (FIOCRUZ), Recife, Brazil.|Universidade Federal de Viçosa, Minas Gerais, Brazil.
authors.forename: Otávio V
authors.initials: OV
authors.lastname: de Carvalho
authors.affiliation: Aggeu Magalhães Research Center, Oswaldo Cruz Foundation (FIOCRUZ), Recife, Brazil.
authors.forename: Leila R
authors.initials: LR
authors.lastname: de Mendonça
authors.affiliation: Aggeu Magalhães Research Center, Oswaldo Cruz Foundation (FIOCRUZ), Recife, Brazil.
authors.forename: Elisa A N
authors.initials: EAN
authors.lastname: Azevedo
authors.affiliation: Aggeu Magalhães Research Center, Oswaldo Cruz Foundation (FIOCRUZ), Recife, Brazil.
authors.forename: Rafael F O
authors.initials: RFO
authors.lastname: França
authors.affiliation: Aggeu Magalhães Research Center, Oswaldo Cruz Foundation (FIOCRUZ), Recife, Brazil.
authors.forename: Rafael
authors.initials: R
authors.lastname: Dhalia
authors.affiliation: Aggeu Magalhães Research Center, Oswaldo Cruz Foundation (FIOCRUZ), Recife, Brazil.|Center for Vaccine Research, University of Pittsburgh, Pennsylvania, USA.|Department of Infectious Disease and Microbiology, University of Pittsburgh, Pennsylvania, USA.
authors.forename: Ernesto T A
authors.initials: ETA
authors.lastname: Marques
mesh_terms: D000914:Antibodies, Viral / Q000097:blood* / Q000276:immunology; D019067:Antibody-Dependent Enhancement; D000998:Antiviral Agents / Q000494:pharmacology; D001938:Brazil; D003429:Cross Reactions; D003716:Dengue Virus; D005260:Female; D006801:Humans; D020014:K562 Cells; D011247:Pregnancy; D017452:Receptors, IgG / Q000276:immunology; D000071244:Zika Virus / Q000472:pathogenicity*; D000071243:Zika Virus Infection / Q000097:blood / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D000998:Antiviral Agents; D017452:Receptors, IgG
keywords: Zika virus; antibody dependent enhancement; dengue antibodies