title: Parotid sclerosing mucoepidermoid carcinoma: a case report and immunohistochemical study.
abstract: Here we report the case of a 63-year-old female with a parotid sclerosing mucoepidermoid carcinoma diagnosed and treated at the Department of Oral and Maxillofacial Surgery, Emergency County Hospital of Craiova, Romania. The clinical and imaging investigation revealed a parotid malignant tumor with central fluid-filled cystic formation. Histopathology found an intermediate grade sclerosing mucoepidermoid carcinoma that invaded the adjacent adipose and striated muscle tissues, but without perineural and lymphovascular invasion. The immunohistochemistry investigated mainly biomarkers involved in the induction of a local aggressive behavior. This case report describes a rare parotid sclerosing mucoepidermoid carcinoma with peculiar clinical and morphological characteristic features. The immunohistochemical study sustained its intermediate grade malignancy highlighting the prognostic value of some of the used biomarkers.
authors.affiliation: Department of Pathology, Faculty of Dentistry, University of Medicine and Pharmacy of Craiova, Romania; c_margaritescu2000@yahoo.com.
authors.forename: Florin Liviu
authors.initials: FL
authors.lastname: Gherghina
authors.forename: Adrian
authors.initials: A
authors.lastname: Camen
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Munteanu
authors.forename: Claudiu
authors.initials: C
authors.lastname: Mărgăritescu
authors.forename: Călin Gabriel
authors.initials: CG
authors.lastname: Şarlă
mesh_terms: D018277:Carcinoma, Mucoepidermoid / Q000276:immunology* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D010307:Parotid Neoplasms / Q000276:immunology* / Q000473:pathology; D011379:Prognosis