title: Lifetime risk of renal replacement therapy in Europe: a population-based study using data from the ERA-EDTA Registry.
abstract: Upcoming KDIGO guidelines for the evaluation of living kidney donors are expected to move towards a personal risk-based evaluation of potential donors. We present the age and sex-specific lifetime risk of renal replacement therapy (RRT) for end-stage renal disease in 10 European countries.
  
  
  
  We defined lifetime risk of RRT as the cumulative incidence of RRT up to age 90 years. We obtained RRT incidence rates per million population by 5-year age groups and sex using data from the European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) Registry, and used these to estimate the cumulative incidence of RRT, adjusting for competing mortality risk.
  
  
  
  Lifetime risk of RRT varied from 0.44% to 2.05% at age 20 years and from 0.17% to 1.59% at age 70 years across countries, and was twice as high in men as in women. Lifetime RRT risk decreased with age, ranging from an average of 0.77% to 0.44% in 20- to- 70-year-old women, and from 1.45% to 0.96% in 20- to- 70-year-old men. The lifetime risk of RRT increased slightly over the past decade, more so in men than in women. However, it appears to have stabilized or even decreased slightly in more recent years.
  
  
  
  The lifetime risk of RRT decreased with age, was lower in women as compared with men of equal age and varied considerably throughout Europe. Given the substantial differences in lifetime risk of RRT between the USA and Europe, country-specific estimates should be used in the evaluation and communication of the risk of RRT for potential living kidney donors.
authors.affiliation: Department of Nephrology, Radboud Institute of Health Science, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: Jan A J G
authors.initials: JAJG
authors.lastname: van den Brand
authors.affiliation: ERA-EDTA Registry, Department of Medical Informatics, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: Maria
authors.initials: M
authors.lastname: Pippias
authors.affiliation: ERA-EDTA Registry, Department of Medical Informatics, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: Vianda S
authors.initials: VS
authors.lastname: Stel
authors.affiliation: Medical Director, UK Renal Registry, Southmead Hospital, Bristol, UK.|Honorary Senior Lecturer, School of Social and Community Medicine, University of Bristol, Bristol, UK.
authors.forename: Fergus J
authors.initials: FJ
authors.lastname: Caskey
authors.affiliation: Nephrology and Dialysis Department, Brugmann Universitry Hospital, Brussels, Belgium.
authors.forename: Frederic
authors.initials: F
authors.lastname: Collart
authors.affiliation: Department of Nephrology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.|Finnish Registry for Kidney Diseases, Helsinki, Finland.
authors.forename: Partik
authors.initials: P
authors.lastname: Finne
authors.affiliation: Department of Medicine, Zealand University Hospital, Roskilde, Denmark.
authors.forename: James
authors.initials: J
authors.lastname: Heaf
authors.affiliation: Université Paris Descartes, INSERM UMRS 1138 Team 22, APHP, Hôpital Necker Enfants Malades, Biostatistics Unit, Paris, France.
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Jais
authors.affiliation: Austrian Dialysis and Transplant Registry, Rohr im Kremstal, Austria.
authors.forename: Reinhard
authors.initials: R
authors.lastname: Kramar
authors.affiliation: Division of Nephrology, Ambroise Paré Univeristy Hospital, Boulogne Billancourt/Paris, France.|INSERM, U-1018 Team 5 (EpReC, Renal and Cardiovascular Epidemiology), CESP, Villejeuf, France.
authors.forename: Ziad A
authors.initials: ZA
authors.lastname: Massy
authors.affiliation: Department of Nephrology and Dialysis and Hypertension, Dutch-Speaking Belgian Renal Registry Sint-Niklaas, Belgium.
authors.forename: Johan
authors.initials: J
authors.lastname: De Meester
authors.affiliation: Scottish Renal Registry, Glasgow, UK.
authors.forename: Jamie P
authors.initials: JP
authors.lastname: Traynor
authors.affiliation: The Norwegian Renal Registry, Department of Nephrology, Department of Transplantation Medicine, Oslo University Hospital Rikshospitalet, Olso, Norway.
authors.forename: Anna Varberg
authors.initials: AV
authors.lastname: Reisæter
authors.affiliation: Department of Nephrology, Radboud Institute of Health Science, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: Jack F M
authors.initials: JFM
authors.lastname: Wetzels
authors.affiliation: ERA-EDTA Registry, Department of Medical Informatics, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: Kitty J
authors.initials: KJ
authors.lastname: Jager
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005006:Ethnicity; D005060:Europe / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D007676:Kidney Failure, Chronic / Q000453:epidemiology* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012042:Registries / Q000706:statistics & numerical data*; D017582:Renal Replacement Therapy / Q000706:statistics & numerical data* / Q000639:trends*; D055815:Young Adult
keywords: end-stage renal disease, lifetime risk, living kidney donor, mortality, renal replacement therapy