title: Current opinion in Alzheimer's disease therapy by nanotechnology-based approaches.
abstract: OBJECTIVE
  Nanotechnology typically deals with the measuring and modeling of matter at nanometer scale by incorporating the fields of engineering and technology. The most prominent feature of these engineered materials involves their manipulation/modification for imparting new functional properties. The current review covers the most recent findings of Alzheimer's disease (AD) therapeutics based on nanoscience and technology.
  
  
  RESULTS
  Current studies involve the application of nanotechnology in developing novel diagnostic and therapeutic tools for neurological disorders. Nanotechnology-based approaches can be exploited for limiting/reversing these diseases for promoting functional regeneration of damaged neurons. These strategies offer neuroprotection by facilitating the delivery of drugs and small molecules more effectively across the blood-brain barrier.
  
  
  CONCLUSIONS
  Nanotechnology based approaches show promise in improving AD therapeutics. Further replication work on synthesis and surface modification of nanoparticles, longer-term clinical trials, and attempts to increase their impact in treating AD are required.
authors.affiliation: aCenter of Excellence in Genomic Medicine Research, King Abdulaziz University bDepartment of Biochemistry, Ibn Sina National College for Medical Studies, Jeddah, Saudi Arabia cDepartment of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, Uttar Pradesh, India dKing Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.
authors.forename: Shakeel Ahmed
authors.initials: SA
authors.lastname: Ansari
authors.forename: Rukhsana
authors.initials: R
authors.lastname: Satar
authors.forename: Asma
authors.initials: A
authors.lastname: Perveen
authors.forename: Ghulam Md
authors.initials: GM
authors.lastname: Ashraf
mesh_terms: D000544:Alzheimer Disease / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000502:physiology; D016503:Drug Delivery Systems; D006801:Humans; D051379:Mice; D053758:Nanoparticles / Q000008:administration & dosage / Q000627:therapeutic use; D036103:Nanotechnology; D051381:Rats