title: Goodpasture Syndrome Diagnosed One Year And A Half after the Appearance of the First Symptoms (Case Report).
abstract: BACKGROUND
  Goodpasture syndrome was originally described as an association of alveolar haemorrhage and glomerulonephritis. It occurs when the immune system attacks and destroys healthy body tissue.
  
  
  OBJECTIVE
  We are presenting a patient with a clinical picture of pulmonary haemorrhage and glomerulonephritis, which is diagnosed by renal biopsy.
  
  
  METHODS
  His illness began a year and a half before being diagnosed. In that period he had occasional exacerbations. He was received at our Clinic in extremely serious condition, and after stabilisation of his medical condition, there was made a biopsy of the kidney. The p-ANCA was 8.93 U/ml (neg < 3, poz > 5 U/ml). Histopathological diagnosis of biopsy of the kidney was: Glomerulonephritis extra capillaries focalis, segmentalis et globalis. Based on this he was diagnosed with Goodpasture syndrome. He received corticosteroid therapy and cyclophosphamide, with good response to treatment, and he is currently in a stable condition, receiving only corticosteroid therapy.
  
  
  CONCLUSIONS
  Goodpasture syndrome is a severe illness caused by the formation of antibodies to the glomerular basement membrane and alveolus with consequential damage to renal and pulmonary function. With current therapy, long-term survival is more than 50%.
authors.affiliation: University Clinic of Pulmonology and Allergology, Medical Faculty, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.
authors.forename: Jagoda
authors.initials: J
authors.lastname: Stojkovikj
authors.affiliation: University Clinic of Pulmonology and Allergology, Medical Faculty, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.
authors.forename: Sead
authors.initials: S
authors.lastname: Zejnel
authors.affiliation: University Clinic of Nephrology, Medical Faculty, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.
authors.forename: Biljana
authors.initials: B
authors.lastname: Gerasimovska
authors.affiliation: University Clinic of Nephrology, Medical Faculty, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.
authors.forename: Vesna
authors.initials: V
authors.lastname: Gerasimovska
authors.affiliation: Primary Health Care "D-r Dijana Jedikovska", Skopje, Republic of Macedonia.
authors.forename: Dragana
authors.initials: D
authors.lastname: Stojkovic
authors.affiliation: Primary Health Care "St. Elena", Skopje, Republic of Macedonia.
authors.forename: Martin
authors.initials: M
authors.lastname: Trajkovski
authors.affiliation: University Clinic of Pulmonology and Allergology, Medical Faculty, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.
authors.forename: Irina
authors.initials: I
authors.lastname: Angelovska
authors.affiliation: University Clinic of Pulmonology and Allergology, Medical Faculty, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.
authors.forename: Angela
authors.initials: A
authors.lastname: Debreslioska
authors.affiliation: University Clinic of Pulmonology and Allergology, Medical Faculty, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.
authors.forename: Smilko
authors.initials: S
authors.lastname: Jovanovski
keywords: Goodpasture syndrome; alveolar haemorrhage; anti-glomerular basement membrane (anti-GBM) antibodies; glomerulonephritis; immune system