title: Dopaminergic modulation of default mode network brain functional connectivity in attention deficit hyperactivity disorder.
abstract: Recent evidence suggests that attention deficit hyperactivity disorder (ADHD) is associated with a range of brain functional connectivity abnormalities, with one of the most prominent being reduced inhibition of the default mode network (DMN) while performing a cognitive task. In this study, we examine the effects of a methylphenidate dose on brain functional connectivity in boys diagnosed with ADHD while they performed a cognitive task.
  
  
  
  Brain functional connectivity was estimated using steady-state visual evoked potential partial coherence before and 90 min after the administration of a methylphenidate dose to 42 stimulant drug-naïve boys newly diagnosed with ADHD while they performed the A-X version of the continuous performance task (CPT A-X).
  
  
  
  Methylphenidate robustly reversed the transient functional connectivity increase in the A-X interval seen premedication to a postmedication decrease during this interval. In addition, methylphenidate-induced reductions in individual reaction time were correlated with corresponding reductions in functional connectivity.
  
  
  
  These findings suggest that methylphenidate suppresses the increased functional connectivity observed in ADHD and that such suppression is associated with improved performance. Our findings support the suggestion that the increased functional connectivity we have observed in ADHD is associated with abnormal DMN activity. In addition, we comment on the significance of specific frequency channels mediating top-down communication within the cortex and the extent to which our findings are selectively sensitive to top-down intracortical communication.
authors.affiliation: Centre for Human Psychopharmacology Swinburne University Hawthorn Vic.Australia; Neuro-Insight Pty Ltd Melbourne Vic. Australia.
authors.forename: Richard B
authors.initials: RB
authors.lastname: Silberstein
authors.affiliation: Centre for Human Psychopharmacology Swinburne University Hawthorn Vic. Australia.
authors.forename: Andrew
authors.initials: A
authors.lastname: Pipingas
authors.affiliation: Wicking Dementia Research and Education Centre University of Tasmania Hobart Australia.
authors.forename: Maree
authors.initials: M
authors.lastname: Farrow
authors.affiliation: Head Child and Family East Prince of Wales Hospital and School of Psychiatry University of New South Wales Sydney NSW Australia.
authors.forename: Florence
authors.initials: F
authors.lastname: Levy
authors.affiliation: Centre for Human Psychopharmacology Swinburne University Hawthorn Vic. Australia.
authors.forename: Con K
authors.initials: CK
authors.lastname: Stough
mesh_terms: D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology; D002648:Child; D003071:Cognition / Q000187:drug effects; D063132:Connectome; D018765:Dopamine Uptake Inhibitors / Q000627:therapeutic use*; D005074:Evoked Potentials, Visual / Q000187:drug effects; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000627:therapeutic use*; D009434:Neural Pathways / Q000187:drug effects* / Q000503:physiopathology
chemical_list: D018765:Dopamine Uptake Inhibitors; D008774:Methylphenidate
keywords: brain functional connectivity; default mode network; dopamine; methylphenidate; steady‐state visually evoked potential