title: Seasonal expression of P450arom and estrogen receptors in scented glands of muskrats (Ondatra zibethicus).
abstract: Male muskrats have one pair of scented glands that grow and involute annually. To investigate the annual changes in the scented gland, we measured the expressions of aromatase cytochromeP-450 (P450arom) and estrogen receptors (ERs) in the scented glands. P450arom was expressed in glandular cells and epithelial cells in the scented glands during the breeding season, and only in glandular cells during the nonbreeding season. ERα and ERβ were also detected in different types of cells in the scented gland during the breeding and nonbreeding seasons. Both mRNA and protein levels of P450arom, ERα, and ERβ were higher in the scented glandular tissues during the breeding season than those during the nonbreeding season. In addition, small RNA sequencing showed that the predicted targets of the significantly changed microRNAs might be the genes encoding P450arom and ERs. In conclusion, the seasonal changes in the expression of P450arom and ERs may be involved in the regulation of scented gland functions.
authors.affiliation: Laboratory of Animal Physiology, College of Biological Sciences and Technology, Beijing Forestry University, Beijing Peoples Republic of China; and.
authors.forename: Haolin
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Laboratory of Animal Physiology, College of Biological Sciences and Technology, Beijing Forestry University, Beijing Peoples Republic of China; and.
authors.forename: Lu
authors.initials: L
authors.lastname: Lu
authors.affiliation: Laboratory of Animal Physiology, College of Biological Sciences and Technology, Beijing Forestry University, Beijing Peoples Republic of China; and.
authors.forename: Manyu
authors.initials: M
authors.lastname: Zhu
authors.affiliation: Laboratory of Animal Physiology, College of Biological Sciences and Technology, Beijing Forestry University, Beijing Peoples Republic of China; and.
authors.forename: Fengwei
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Laboratory of Animal Physiology, College of Biological Sciences and Technology, Beijing Forestry University, Beijing Peoples Republic of China; and.
authors.forename: Xia
authors.initials: X
authors.lastname: Sheng
authors.affiliation: Laboratory of Animal Physiology, College of Biological Sciences and Technology, Beijing Forestry University, Beijing Peoples Republic of China; and.
authors.forename: Zhengrong
authors.initials: Z
authors.lastname: Yuan
authors.affiliation: Laboratory of Animal Physiology, College of Biological Sciences and Technology, Beijing Forestry University, Beijing Peoples Republic of China; and.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Han
authors.affiliation: Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Tokyo University of Agriculture and Technology, Tokyo, Japan.
authors.forename: Gen
authors.initials: G
authors.lastname: Watanabe
authors.affiliation: Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Tokyo University of Agriculture and Technology, Tokyo, Japan.
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Taya
authors.affiliation: Laboratory of Animal Physiology, College of Biological Sciences and Technology, Beijing Forestry University, Beijing Peoples Republic of China; and qiangweng@bjfu.edu.cn.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Weng
mesh_terms: D000064:Acclimatization / Q000502:physiology*; D000818:Animals; D001141:Aromatase / Q000378:metabolism*; D003411:Arvicolinae / Q000502:physiology*; D001947:Breeding / Q000379:methods; D005786:Gene Expression Regulation / Q000502:physiology; D008297:Male; D011960:Receptors, Estrogen / Q000502:physiology*; D012543:Scent Glands / Q000502:physiology*; D012621:Seasons; D012726:Sexual Behavior, Animal / Q000502:physiology*
chemical_list: D011960:Receptors, Estrogen; D001141:Aromatase
keywords: P450arom; estrogen receptors; microRNA; muskrat; scented gland