title: Oral perineurioma: clinicopathologic features from two cases and review of literature.
abstract: The present study reports two cases of oral perineuriomas, including a clinicopathologic review of the 39 published cases (17 intraneural and 22 extraneural perineuriomas) in the English language literature. In the first case, the tumor occurred in an 84-year-old male as a painless, asymptomatic, 20-mm submucosal nodule on the right lower mucobuccal fold near to the premolar area. In the second case, a 46-year-old female presented with a painless, 25-mm, slow-growing, fibrous, pedunculated nodule on the right buccal mucosa. In the first case, the tumor was composed of spindle cells arranged in a storiform pattern, classified as intraneural perineurioma; and in the second, it was an extraneural perineurioma, showing a whorled myxoid stroma. Immunohistochemical analysis confirmed the diagnosis by showing positivity for vimentin, EMA, and Glut-1 in case 1 and EMA, Glut-1, Claudin-1, and CD34 (focally) in case 2. Complete surgical removal was performed for both tumors, and there was no evidence of local recurrence after a long-term follow-up.
authors.affiliation: Oral Pathology, Piracicaba Dental School, University of Campinas, Piracicaba, Sao Paulo, Brazil.
authors.forename: Wagner
authors.initials: W
authors.lastname: Gomes da Silva
authors.affiliation: Oral Pathology, Piracicaba Dental School, University of Campinas, Piracicaba, Sao Paulo, Brazil.
authors.forename: Marisol Martínez
authors.initials: MM
authors.lastname: Martínez
authors.affiliation: Stomatology Service, Brazilian Dental Association, Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Águida Maria Menezes Aguiar
authors.initials: ÁM
authors.lastname: Miranda
authors.affiliation: Oral and Maxillofacial Surgery, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Roberto Bastos
authors.initials: RB
authors.lastname: Silva
authors.affiliation: Oral and Maxillofacial Surgery, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Henrique Martins
authors.initials: HM
authors.lastname: da Silveira
authors.affiliation: Oral Pathology, Piracicaba Dental School, University of Campinas, Piracicaba, Sao Paulo, Brazil.
authors.forename: Oslei Paes
authors.initials: OP
authors.lastname: de Almeida
authors.affiliation: Stomatology Service, Brazilian Dental Association, Rio de Janeiro, Rio de Janeiro, Brazil; Oral Pathology, School of Dentistry, State University of Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address: Ramoafop@yahoo.com.
authors.forename: Fábio Ramôa
authors.initials: FR
authors.lastname: Pires
mesh_terms: D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology*; D009062:Mouth Neoplasms / Q000473:pathology* / Q000601:surgery; D018317:Nerve Sheath Neoplasms / Q000473:pathology* / Q000601:surgery