title: Multicenter Study of the Clinical Presentation of Staphylococcus lugdunensis Bacteremia in Japan.
abstract: Staphylococcus lugdunensis (SL) is a bacterium with a highly pathogenicity than most other coagulase-negative Staphylococcus spp. (CoNS). In Japan, data on this pathogen are sparse, and the current prevalence of SL bacteremia is unknown. Therefore, we investigated the prevalence of SL in blood culture specimens in a prospective multicenter study across 5 facilities. A total of 3,284 patients had positive blood cultures, and 2,478 patients had bacteremia. Among the patients with bacteremia, 7 patients (0.28%) had SL bacteremia. A total of 281 patients had CoNS bacteremia, with SL accounting for 2.49% of these cases. Of the 7 patients with SL bacteremia, 1 patient (14.3%) had infective endocarditis, and 1 patient (14.3%) died within 30 days. In this study, SL resulted in the development of bacteremia in select patients. Clinicians in Japan should be aware of the prevalence of SL and the complications of SL bacteremia.
authors.affiliation: Disease Control and Prevention Center, National Center for Global Health and Medicine.|Department of Infectious Diseases, Tokyo Metropolitan Health and Medical Corporation Ebara Hospital.|Department of Infectious Diseases, Tokyo Women's Medical University.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Ainoda
authors.affiliation: Disease Control and Prevention Center, National Center for Global Health and Medicine.
authors.forename: Nozomi
authors.initials: N
authors.lastname: Takeshita
authors.affiliation: Department of Infectious Diseases, Kameda Medical Center.|Department of Infectious Diseases, Narita Red Cross Hospital.
authors.forename: Ryota
authors.initials: R
authors.lastname: Hase
authors.affiliation: Department of Infectious Diseases, Kameda Medical Center.|Department of General Medicine and Infectious Diseases, Yamanashi Prefectural Central Hospital.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Mikawa
authors.affiliation: Department of Infectious Diseases, Kameda Medical Center.
authors.forename: Naoto
authors.initials: N
authors.lastname: Hosokawa
authors.affiliation: Division of Infectious Diseases, Shizuoka Cancer Center.
authors.forename: Ichiro
authors.initials: I
authors.lastname: Kawamura
authors.affiliation: Division of Infectious Diseases, Shizuoka Cancer Center.
authors.forename: Hanako
authors.initials: H
authors.lastname: Kurai
authors.affiliation: Department of Infectious Diseases, Toranomon Hospital.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Abe
authors.affiliation: Department of Infectious Diseases, Toranomon Hospital.
authors.forename: Muneyoshi
authors.initials: M
authors.lastname: Kimura
authors.affiliation: Department of Infectious Diseases, Toranomon Hospital.
authors.forename: Hideki
authors.initials: H
authors.lastname: Araoka
authors.affiliation: Department of Infectious Diseases, Tokyo Women's Medical University.|Center for Home Care Medicine, Faculty of Medicine, The University of Tokyo.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Fujita
authors.affiliation: Department of Infectious Diseases, Tokyo Women's Medical University.|Department of Internal Medicine, Kita-tama Hospital.
authors.forename: Kyoichi
authors.initials: K
authors.lastname: Totsuka
authors.affiliation: Disease Control and Prevention Center, National Center for Global Health and Medicine.
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Mezaki
authors.affiliation: Department of Clinical Laboratory, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital.
authors.forename: Noritaka
authors.initials: N
authors.lastname: Sekiya
authors.affiliation: Disease Control and Prevention Center, National Center for Global Health and Medicine.
authors.forename: Norio
authors.initials: N
authors.lastname: Ohmagari
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016470:Bacteremia / Q000453:epidemiology / Q000382:microbiology* / Q000401:mortality / Q000473:pathology*; D001769:Blood / Q000382:microbiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D013203:Staphylococcal Infections / Q000453:epidemiology / Q000382:microbiology* / Q000401:mortality / Q000473:pathology*; D057787:Staphylococcus lugdunensis / Q000302:isolation & purification*; D016019:Survival Analysis; D055815:Young Adult
keywords: Japan; Staphylococcus lugdunensis; incidence