title: Clinicopathological Features of Cervical Esophageal Cancer: Retrospective Analysis of 63 Consecutive Patients Who Underwent Surgical Resection.
abstract: The objectives of this retrospective study were to elucidate the clinicopathological features and recent surgical results of cervical esophageal cancer.
  
  
  
  Cervical esophageal cancer has been reported to have a dismal prognosis. Accurate knowledge of the clinical characteristics of cervical esophageal cancer is warranted to establish appropriate therapeutic strategies.
  
  
  
  The clinicopathological features and treatment results of 63 consecutive patients with cervical esophageal cancer (Ce group) who underwent surgical resection from 1980 to 2013 were analyzed and compared with 977 patients with thoracic or abdominal esophageal cancer (T/A group) who underwent surgical resection during that time.
  
  
  
  Among the patients who received curative resection, the 5-year overall and disease-specific survival rates of the Ce patients were significantly better than those of the T/A patients (overall: 77.3% vs 46.5%, respectively, P = 0.0067; disease-specific: 81.9% vs 55.8%, respectively, P = 0.0135). Although total pharyngo-laryngo-esophagectomy procedures were less frequently performed in the recent period, the rate of curative surgical procedures was markedly higher in the recent period (2000-1013) than that in the early period (1980-1999) (44.4% vs 88.9%, P = 0.0001). The 5-year overall survival rate in the recent period (71.5%) was significantly better than that in the early period (40.7%, P = 0.0342).
  
  
  
  Curative resection for cervical esophageal cancer contributes to favorable outcomes compared with other esophageal cancers. Recent surgical results for cervical esophageal cancer have improved, and include an increased rate of curative resection and decreased rate of extensive surgery.
authors.affiliation: *Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan †Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan ‡Department of Gastroenterological Surgery, National Kyushu Cancer Center, Fukuoka, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Saeki
authors.forename: Satoshi
authors.initials: S
authors.lastname: Tsutsumi
authors.forename: Takafumi
authors.initials: T
authors.lastname: Yukaya
authors.forename: Hirotada
authors.initials: H
authors.lastname: Tajiri
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Tsutsumi
authors.forename: Sho
authors.initials: S
authors.lastname: Nishimura
authors.forename: Yu
authors.initials: Y
authors.lastname: Nakaji
authors.forename: Kensuke
authors.initials: K
authors.lastname: Kudou
authors.forename: Shingo
authors.initials: S
authors.lastname: Akiyama
authors.forename: Yuta
authors.initials: Y
authors.lastname: Kasagi
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Nakashima
authors.forename: Masahiko
authors.initials: M
authors.lastname: Sugiyama
authors.forename: Hideto
authors.initials: H
authors.lastname: Sonoda
authors.forename: Kippei
authors.initials: K
authors.lastname: Ohgaki
authors.forename: Eiji
authors.initials: E
authors.lastname: Oki
authors.forename: Ryuji
authors.initials: R
authors.lastname: Yasumatsu
authors.forename: Torahiko
authors.initials: T
authors.lastname: Nakashima
authors.forename: Masaru
authors.initials: M
authors.lastname: Morita
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Maehara
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D016022:Case-Control Studies; D004938:Esophageal Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D016629:Esophagectomy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009333:Neck; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome