title: Adenosine A2Areceptor deletion affects social behaviors and anxiety in mice: Involvement of anterior cingulate cortex and amygdala.
abstract: Blockade of adenosine A2Areceptors can potentiate motivation to work for natural reinforcers such as food. Conspecific interaction is a potent natural reinforcer in social animals that can be manifested as preference for social exploration versus other sources of novel stimulation. Deficiencies in this type of motivated behavior (social withdrawal) have been seen in several pathologies such as autism and depression. However, the role of A2Areceptors in motivation for social interaction has not been widely explored. Social interaction paradigms evaluate the natural preference of animals for exploring other conspecifics, and the ability to differentiate between familiar versus novel ones. Anxiety is one of the factors that can induce avoidance of social interaction. In the present study, adenosine A2Aknockout (A2AKO) and wild-type (WT) mice were assessed for social and anxiety-related behaviors. c-Fos immunoreactivity was evaluated as a measure of neuronal activation in brain areas involved in different aspects of motivation and emotional processes. Although A2AKO mice showed an anxious profile, they displayed higher levels of sociability and were less sensitive to social novelty. WT mice displayed a typical pattern of social recognition 24h later, but not A2AKO mice, which explored equally both conspecifics. There were no differences between strains in aggressiveness, perseverance or social odor preferences. c-Fos immunoreactivity in A2AKO mice was higher in anterior cingulate and amygdala compared to WT mice. Thus, A2Areceptors appear to be potential targets for the improvement of pathologies related to social function.
authors.affiliation: Àrea de Psicobiologia, Campus de Riu Sec, Universitat Jaume I, 12071 Castelló, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: López-Cruz
authors.affiliation: Àrea de Psicobiologia, Campus de Riu Sec, Universitat Jaume I, 12071 Castelló, Spain.
authors.forename: Maria
authors.initials: M
authors.lastname: Carbó-Gas
authors.affiliation: Àrea de Psicobiologia, Campus de Riu Sec, Universitat Jaume I, 12071 Castelló, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Pardo
authors.affiliation: Àrea de Psicobiologia, Campus de Riu Sec, Universitat Jaume I, 12071 Castelló, Spain.
authors.forename: Pilar
authors.initials: P
authors.lastname: Bayarri
authors.affiliation: Grup de Recerca en Neurobiologia del Comportament (GReNeC), Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Hospital del Mar Medical Research Institute (IMIM), Dr. Aiguader 88, 08003 Barcelona, Spain.
authors.forename: Olga
authors.initials: O
authors.lastname: Valverde
authors.affiliation: Universite Libre de Bruxelles, IRIBHM, Campus Erasme, CP602, route de Lennik 808, 1070 Bruxelles, Belgium.
authors.forename: Catherine
authors.initials: C
authors.lastname: Ledent
authors.affiliation: Department of Psychology, University of Connecticut, Storrs, CT, 06269-1020, USA.
authors.forename: John D
authors.initials: JD
authors.lastname: Salamone
authors.affiliation: Àrea de Psicobiologia, Campus de Riu Sec, Universitat Jaume I, 12071 Castelló, Spain; Department of Psychology, University of Connecticut, Storrs, CT, 06269-1020, USA. Electronic address: correa@psb.uji.es.
authors.forename: Mercè
authors.initials: M
authors.lastname: Correa
mesh_terms: D000679:Amygdala / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D001007:Anxiety / Q000378:metabolism*; D006179:Gyrus Cinguli / Q000378:metabolism* / Q000473:pathology; D007150:Immunohistochemistry; D008297:Male; D018345:Mice, Knockout; D009474:Neurons / Q000378:metabolism / Q000473:pathology; D055696:Olfactory Perception / Q000502:physiology; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism; D011581:Psychological Tests; D043705:Receptor, Adenosine A2A / Q000172:deficiency*; D021641:Recognition, Psychology / Q000502:physiology; D012919:Social Behavior
chemical_list: D016760:Proto-Oncogene Proteins c-fos; D043705:Receptor, Adenosine A2A
keywords: Adenosine; Aggressive behavior; Marble-burying test; Social preference; Social recognition; c-Fos