title: Role ofdupAin virulence ofHelicobacter pylori.
abstract: Helicobacter pylori(H. pylori) is a gastric human pathogen associated with acute and chronic gastritis, 70% of all gastric ulcers, 85% of all duodenal ulcers, and both forms of stomach cancer, mucosal-associated lymphoid tissue (MALT) lymphoma and adenocarcinoma. Recently, attention has focused on possible relationship between presence of certain virulence factor andH. pylori-associated diseases. Some contradictory data between this bacterium and related disorders has been observed since not all the colonized individuals develop to severe disease. The reported diseases plausibility related toH. pylorispecific virulence factors became an interesting story about this organism. Although a number of putative virulence factors have been identified including cytotoxin-associated gene a (cagA) andvacA, there are conflicting data about their actual participation as specific risk factor forH. pylori-related diseases. Duodenal ulcer promoting gene a (dupA) is a virulence factor ofH. pylorithat is highly associated with duodenal ulcer development and reduced risk of gastric cancer. The prevalence ofdupAinH. pyloristrains isolated from western countries is relatively higher than inH. pyloristrains from Asian countries. Current confusing epidemiological reports will continue unless future sophisticated and molecular studies provide data on functional and completedupAcluster inH. pyloriinfected individuals. This paper elucidates available knowledge concerning role ofdupAin virulence ofH. pyloriafter a decade of its discovery.
authors.affiliation: Amin Talebi Bezmin Abadi, Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran 14115-111, Iran.
authors.forename: Amin
authors.initials: A
authors.lastname: Talebi Bezmin Abadi
authors.affiliation: Amin Talebi Bezmin Abadi, Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran 14115-111, Iran.
authors.forename: Guillermo
authors.initials: G
authors.lastname: Perez-Perez
mesh_terms: D000942:Antigens, Bacterial; D001208:Asia / Q000453:epidemiology; D001426:Bacterial Proteins; D004381:Duodenal Ulcer / Q000453:epidemiology / Q000382:microbiology*; D005756:Gastritis / Q000453:epidemiology / Q000382:microbiology*; D016481:Helicobacter Infections / Q000453:epidemiology / Q000382:microbiology*; D016480:Helicobacter pylori / Q000472:pathogenicity* / Q000502:physiology; D006801:Humans; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000382:microbiology; D037521:Virulence Factors / Q000502:physiology*
chemical_list: D000942:Antigens, Bacterial; D001426:Bacterial Proteins; C528428:DupA protein, Helicobacter pylori; C074689:VacA protein, Helicobacter pylori; D037521:Virulence Factors; C080866:cagA protein, Helicobacter pylori
keywords: Bacterial virulence; Clinical outcome; Helicobacter pylori; Infection; dupA