title: HLA-DQA1 and HLA-DQB1 allele diversity and its extended haplotypes in Madeira Island (Portugal).
abstract: This study shows, for the first time, high-resolution allele frequencies of HLA-DQA1 loci in Madeira Island (Portugal) and allows us to better understand and refine present knowledge on DQB1 variation, with the identification of several alleles not previously reported in this population. Estimates on haplotype profile, involving HLA-A, HLA-B, HLA-DRB1, HLA-DQA1 and HLA-DQB1, are also reported.
authors.affiliation: Human Genetics Laboratory, University of Madeira, Funchal, Portugal.
authors.forename: H
authors.initials: H
authors.lastname: Spínola
authors.affiliation: Human Genetics Laboratory, University of Madeira, Funchal, Portugal.
authors.forename: A
authors.initials: A
authors.lastname: Lemos
authors.affiliation: SEEBMO, Hospital Santo Espírito de Angra do Heroísmo, Azores, Portugal.|Genetics and Arthritis Research Group - I3S, University of Porto, Porto, Portugal.
authors.forename: A R
authors.initials: AR
authors.lastname: Couto
authors.affiliation: SEEBMO, Hospital Santo Espírito de Angra do Heroísmo, Azores, Portugal.|Genetics and Arthritis Research Group - I3S, University of Porto, Porto, Portugal.
authors.forename: B
authors.initials: B
authors.lastname: Parreira
authors.affiliation: SEEBMO, Hospital Santo Espírito de Angra do Heroísmo, Azores, Portugal.|Genetics and Arthritis Research Group - I3S, University of Porto, Porto, Portugal.
authors.forename: M
authors.initials: M
authors.lastname: Soares
authors.affiliation: SEEBMO, Hospital Santo Espírito de Angra do Heroísmo, Azores, Portugal.|Genetics and Arthritis Research Group - I3S, University of Porto, Porto, Portugal.
authors.forename: I
authors.initials: I
authors.lastname: Dutra
authors.affiliation: SEEBMO, Hospital Santo Espírito de Angra do Heroísmo, Azores, Portugal.|Genetics and Arthritis Research Group - I3S, University of Porto, Porto, Portugal.
authors.forename: J
authors.initials: J
authors.lastname: Bruges-Armas
authors.affiliation: Human Genetics Laboratory, University of Madeira, Funchal, Portugal.
authors.forename: A
authors.initials: A
authors.lastname: Brehm
mesh_terms: D000483:Alleles; D005260:Female; D015870:Gene Expression; D005787:Gene Frequency; D014644:Genetic Variation; D015234:HLA-A Antigens / Q000235:genetics / Q000276:immunology; D015235:HLA-B Antigens / Q000235:genetics / Q000276:immunology; D059848:HLA-DQ alpha-Chains / Q000235:genetics* / Q000276:immunology; D059866:HLA-DQ beta-Chains / Q000235:genetics* / Q000276:immunology; D059811:HLA-DRB1 Chains / Q000235:genetics / Q000276:immunology; D006239:Haplotypes; D006801:Humans; D008297:Male; D011174:Portugal
chemical_list: D015234:HLA-A Antigens; D015235:HLA-B Antigens; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; C069050:HLA-DQA1 antigen; C069051:HLA-DQB1 antigen; D059811:HLA-DRB1 Chains