title: Critical view on drug dissolution in artificial saliva: A possible use of in-line e-tongue measurements.
abstract: Proper monitoring of drug's dissolution is a prerequisite for assessing of taste masking efficacy of pharmaceuticals. Corresponding dissolution procedure is likely to be performed with water. Since the objective of these tests is to examine fate of a pharmaceutical formulation in oral cavity, this choice of solvent seems unsuitable because physical and chemical properties of human saliva are quite far from those of water. Obviously, dissolution profiles registered in water may differ significantly from what really happens with a drug in a mouth cavity. In order to address this discrepancy we examined three different compositions of artificial saliva in dissolution test context in present study. It was found that certain compositions preclude the employment of traditional UV-vis spectroscopy as a detection tool due to strong light scattering in the media caused by viscosity and protein composition modifiers. This issue was circumvented by the use of in-line applied potentiometric multisensor system (e-tongue) and the potential of this new approach for more biorelevant dissolution tests was demonstrated with two model formulations of quinine and ibuprofen.
authors.affiliation: Institute of Chemistry, St. Petersburg State University, Universitetskaya nab. 7/9, Mendeleev Center, 199034 St. Petersburg, Russia; Laboratory of Artificial Sensory Systems, ITMO University, Kronverkskiy Pr., 49, 197101 St. Petersburg, Russia.
authors.forename: Maria
authors.initials: M
authors.lastname: Khaydukova
authors.affiliation: Institute of Chemistry, St. Petersburg State University, Universitetskaya nab. 7/9, Mendeleev Center, 199034 St. Petersburg, Russia; Laboratory of Artificial Sensory Systems, ITMO University, Kronverkskiy Pr., 49, 197101 St. Petersburg, Russia. Electronic address: d.kirsanov@gmail.com.
authors.forename: Dmitry
authors.initials: D
authors.lastname: Kirsanov
authors.affiliation: Life Science Technologies, University of Applied Sciences Ostwestfalen-Lippe, Detmold, Germany.
authors.forename: Miriam
authors.initials: M
authors.lastname: Pein-Hackelbusch
authors.affiliation: Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
authors.forename: L Isabell
authors.initials: LI
authors.lastname: Immohr
authors.affiliation: Institute of Chemistry, St. Petersburg State University, Universitetskaya nab. 7/9, Mendeleev Center, 199034 St. Petersburg, Russia.
authors.forename: Venera
authors.initials: V
authors.lastname: Gilemkhanova
authors.affiliation: Institute of Chemistry, St. Petersburg State University, Universitetskaya nab. 7/9, Mendeleev Center, 199034 St. Petersburg, Russia; Laboratory of Artificial Sensory Systems, ITMO University, Kronverkskiy Pr., 49, 197101 St. Petersburg, Russia.
authors.forename: Andrey
authors.initials: A
authors.lastname: Legin
mesh_terms: D000284:Administration, Oral; D002626:Chemistry, Pharmaceutical / Q000379:methods; D065546:Drug Liberation / Q000187:drug effects; D007052:Ibuprofen / Q000008:administration & dosage* / Q000737:chemistry*; D011803:Quinine / Q000008:administration & dosage* / Q000737:chemistry*; D012464:Saliva, Artificial / Q000737:chemistry*; D012995:Solubility; D013649:Taste; D013678:Technology, Pharmaceutical / Q000379:methods; D014059:Tongue / Q000378:metabolism*; D014783:Viscosity
chemical_list: D012464:Saliva, Artificial; D011803:Quinine; D007052:Ibuprofen
keywords: Artificial saliva; Dissolution test; Electronic tongue