title: Malignant Oestrogen-producing Teratoma in a Cat.
abstract: A 5-year-old female domestic shorthair cat was presented with abdominal distension and serum biochemical evaluation indicated a high concentration of oestradiol (32.81 pg/ml). Exploratory laparotomy revealed a large cystic mass in the right ovary with cystic fluid containing a high level of oestradiol (18.80 pg/ml). The tumour was composed of immature neuroectodermal tissue, mature cartilage, smooth muscle, adipose tissue and aggregated, poorly differentiated mesenchymal cells. It contained cysts of various sizes that were lined by epithelium of different types. The basal layer of the lining epithelium was shown to express aromatase by immunohistochemistry. The findings suggest that this was a novel, malignant, oestrogen-secreting teratoma and that the aromatase-positive, neoplastic cells may have been the source of elevated levels of serum oestrogen.
authors.affiliation: Laboratory of Veterinary Pathology, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Machida
authors.affiliation: Laboratory of Veterinary Pathology, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Michishita
authors.affiliation: Laboratory of Reproduction and, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan; Family Animal Clinic, Nagareyama City, Chiba Prefecture, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Wada
authors.affiliation: Laboratory of Reproduction and, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Hori
authors.affiliation: Laboratory of Reproduction and, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.
authors.forename: E
authors.initials: E
authors.lastname: Kawakami
authors.affiliation: Laboratory of Physiological Pathology, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Yoshimura
authors.affiliation: Laboratory of Veterinary Pathology, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Ohkusu-Tsukada
authors.affiliation: Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Taya
authors.affiliation: Laboratory of Veterinary Pathology, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan. Electronic address: kimimasa@nvlu.ac.jp.
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis; D002371:Cat Diseases / Q000473:pathology*; D002415:Cats; D004967:Estrogens / Q000097:blood*; D005260:Female; D007150:Immunohistochemistry; D010051:Ovarian Neoplasms / Q000662:veterinary*; D013724:Teratoma / Q000662:veterinary*
chemical_list: D014408:Biomarkers, Tumor; D004967:Estrogens
keywords: cat; oestrogen; ovary; teratoma