title: The development of the method for the determination of terbinafine in cat's plasma and hair.
abstract: Clinical investigations of terbinafine indicate its high treatment activity against infections by several dermatophytes. Its efficiency was tested also in the treatment of microsporosis in cats. The distribution of terbinafine in cat's plasma and hair is important for the identification of the drug efficiency. A fast and reliable reversed-phase high performance liquid chromatographic method with appropriate sample preparation has been developed.Reliability, good reproducibility and low detection limit (LOD 0.25 ng/ml) of the method enable determination of terbinafine in hair and also in plasma of cats infected with Microsporum canis treated by Lamisil®tablets.
authors.affiliation: Institute of Physiology, Pharmacology and Toxicology, Veterinary faculty, University of Ljubljana, Gerbičeva 60, 1115 Ljubljana, Slovenia, Slovenia.
authors.forename: Nevenka Kožuh
authors.initials: NK
authors.lastname: Eržen
authors.affiliation: Institute of Physiology, Pharmacology and Toxicology, Veterinary faculty, University of Ljubljana, Gerbičeva 60, 1115 Ljubljana, Slovenia, Slovenia.
authors.forename: Jernej
authors.initials: J
authors.lastname: Kužner
authors.affiliation: Institute of Physiology, Pharmacology and Toxicology, Veterinary faculty, University of Ljubljana, Gerbičeva 60, 1115 Ljubljana, Slovenia, Slovenia.
authors.forename: Marinka
authors.initials: M
authors.lastname: Drobnič-Košorok
keywords: HPLC method; Key words: microsporosis; cats; terbinafine