title: Transitional B cell subsets-a convincing predictive biomarker for allograft loss?
abstract: In this issue, Cherukuri and colleagues describe a convincing association between the proportion of transitional B lymphocyte subsets in kidney transplant recipients and long-term outcomes, and present a biologically plausible mechanism, based on differential ability of T1 and T2 cells to regulate in vitro T cell responses to explain the link. Further work is clearly needed to validate their claim that measurement of T1/T2 ratios may represent a reliable and reproducible predictive biomarker of transplant outcomes.
authors.affiliation: King's College London, MRC Centre for Transplantation, London, UK.
authors.forename: Hannah
authors.initials: H
authors.lastname: Burton
authors.affiliation: King's College London, MRC Centre for Transplantation, London, UK. Electronic address: anthony.dorling@kcl.ac.uk.
authors.forename: Anthony
authors.initials: A
authors.lastname: Dorling
mesh_terms: D064591:Allografts; D016175:B-Lymphocyte Subsets; D015415:Biomarkers; D016030:Kidney Transplantation; D054448:Precursor Cells, B-Lymphoid; D014184:Transplantation, Homologous
chemical_list: D015415:Biomarkers