title: Should we be offering fertility preservation by surgical sperm retrieval to men with Klinefelter syndrome?
abstract: Advances in surgical sperm retrieval have greatly increased the chances of men with Klinefelter syndrome achieving biological paternity. Despite this, the vast majority of attempts to achieve fertility by using extracted gametes to fertilize eggs in vitro do not result in viable pregnancies. A powerful obstacle to success lies with the natural history of seminiferous tubule and germ cell function in Klinefelter syndrome, which typically peak (and thereafter steeply decline) up to a decade before most individuals would be contemplating paternity. Herein we discuss, in relation to a real clinical case, both the exciting technical advances surgical sperm retrieval and the logistic and ethical factors that, in practice, may act to limit their successful application.
authors.affiliation: Newcastle Fertility Centre at Life, Newcastle-upon-Tyne Hospitals, Newcastle-upon-Tyne, UK.
authors.forename: Kevin
authors.initials: K
authors.lastname: McEleny
authors.affiliation: Endocrine Research Group, Institute of Genetic Medicine, University of Newcastle-upon-Tyne, Newcastle-upon-Tyne, UK.|Department of Paediatric Endocrinology, Newcastle-upon-Tyne Hospitals, Newcastle-upon-Tyne, UK.
authors.forename: Tim
authors.initials: T
authors.lastname: Cheetham
authors.affiliation: Endocrine Research Group, Institute of Genetic Medicine, University of Newcastle-upon-Tyne, Newcastle-upon-Tyne, UK.|Department of Endocrinology, Newcastle-upon-Tyne Hospitals, Newcastle-upon-Tyne, UK.
authors.forename: Richard
authors.initials: R
authors.lastname: Quinton
mesh_terms: D002648:Child; D059247:Fertility Preservation / Q000379:methods* / Q000639:trends; D006801:Humans; D007713:Klinefelter Syndrome / Q000523:psychology / Q000628:therapy*; D008297:Male; D053625:Sperm Retrieval / Q000941:ethics / Q000523:psychology / Q000639:trends