title: Sex differences in verbal and nonverbal learning before and after temporal lobe epilepsy surgery.
abstract: Women outperform men in a host of episodic memory tasks, yet the neuroanatomical basis for this effect is unclear. It has been suggested that the anterior temporal lobe might be especially relevant for sex differences in memory. In the current study, we investigated whether temporal lobe epilepsy (TLE) has an influence on sex effects in learning and memory and whether women and men with TLE differ in their risk for memory deficits after epilepsy surgery. 177 patients (53 women and 41 men with left TLE, 42 women and 41 men with right TLE) were neuropsychologically tested before and one year after temporal lobe resection. We found that women with TLE had better verbal, but not figural, memory than men with TLE. The female advantage in verbal memory was not affected by temporal lobe resection. The same pattern of results was found in a more homogeneous subsample of 84 patients with only hippocampal sclerosis who were seizure-free after surgery. Our findings challenge the concept that the anterior temporal lobe plays a central role in the verbal memory advantage for women.
authors.affiliation: Epilepsy-Center Berlin-Brandenburg, Berlin, Germany. Electronic address: j.berger@keh-berlin.de.
authors.forename: Justus
authors.initials: J
authors.lastname: Berger
authors.affiliation: Epilepsy-Center Berlin-Brandenburg, Berlin, Germany. Electronic address: f.oltmanns@keh-berlin.de.
authors.forename: Frank
authors.initials: F
authors.lastname: Oltmanns
authors.affiliation: Epilepsy-Center Berlin-Brandenburg, Berlin, Germany; Department of Neurology, Charité - Universitätsmedizin, Berlin, Germany. Electronic address: martin.holtkamp@charite.de.
authors.forename: Martin
authors.initials: M
authors.lastname: Holtkamp
authors.affiliation: Epilepsy-Center Berlin-Brandenburg, Berlin, Germany. Electronic address: t.bengner@keh-berlin.de.
authors.forename: Thomas
authors.initials: T
authors.lastname: Bengner
mesh_terms: D000328:Adult; D004833:Epilepsy, Temporal Lobe / Q000503:physiopathology / Q000523:psychology* / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000503:physiopathology / Q000523:psychology; D008875:Middle Aged; D009483:Neuropsychological Tests; D009633:Nonverbal Communication / Q000502:physiology / Q000523:psychology; D012189:Retrospective Studies; D012727:Sex Characteristics; D013702:Temporal Lobe / Q000502:physiology* / Q000601:surgery*; D014706:Verbal Learning / Q000502:physiology*; D055815:Young Adult
keywords: Epilepsy surgery; Learning; Nonverbal memory; Sex differences; Temporal lobe epilepsy; Verbal memory