title: Sodium tanshinone IIA sulfonate attenuates hemorrhagic shock-induced organ damages by nuclear factor-kappa B pathway.
abstract: Trauma resulted hemorrhagic shock (HS) leads to increased oxidative stress and inflammatory responses, which contributes greatly to organ failure or dysfunction. Tanshinone IIA sulfonate (TSA), as an antioxidant, may potentially be used in fluid resuscitation to prevent HS-induced organ damages.
  
  
  
  In this study, a rat HS model was constructed. HS rats received TSA or vehicle drug during resuscitation. Mean arterial pressure and factors associated with organ failure or dysfunction, oxidative stress, and inflammatory response were investigated to evaluate treatment responses. Expression of proteins in NF-кB pathway was evaluated to elucidate the mechanism of TSA in preventing HS-induced organ damage.
  
  
  
  Although HS induced organ damage and upregulated oxidative stress and inflammatory response, TSA treatment ameliorated organ dysfunction, reduced oxidative stress, and suppressed inflammatory responses. We also showed that TSA treatment attenuated HS-induced activation in NF-кB pathway.
  
  
  
  TSA can potentially serve as an antioxidant for ameliorating HS-induced organ failure or function. Its mechanism of action may be through inhibiting NF-кB pathway.
authors.affiliation: HuZhou Maternity and Child Care Hospital, HuZhou, Zhejiang, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Qian
authors.affiliation: HuZhou Maternity and Child Care Hospital, HuZhou, Zhejiang, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Ren
authors.affiliation: HuZhou Maternity and Child Care Hospital, HuZhou, Zhejiang, China. Electronic address: xiays66@sina.com.
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Xia
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D007249:Inflammation / Q000188:drug therapy; D008297:Male; D009102:Multiple Organ Failure / Q000209:etiology / Q000517:prevention & control*; D016328:NF-kappa B / Q000378:metabolism*; D018384:Oxidative Stress / Q000187:drug effects; D010616:Phenanthrenes / Q000494:pharmacology / Q000627:therapeutic use*; D008517:Phytotherapy; D017208:Rats, Wistar; D012151:Resuscitation / Q000009:adverse effects; D012771:Shock, Hemorrhagic / Q000150:complications* / Q000188:drug therapy
chemical_list: D004365:Drugs, Chinese Herbal; D016328:NF-kappa B; D010616:Phenanthrenes; C024894:tanshinone II A sodium sulfonate
keywords: Hemorrhagic shock; Inflammatory response; NF-кB; Organ damage; Oxidative stress; Tanshinone IIA sulfonate