title: Model-Based Population Pharmacokinetic Analysis of Nivolumab in Patients With Solid Tumors.
abstract: Nivolumab is a fully human monoclonal antibody that inhibits programmed death-1 activation. The clinical pharmacology profile of nivolumab was analyzed by a population pharmacokinetics model that assessed covariate effects on nivolumab concentrations in 1,895 patients who received 0.3-10.0 mg/kg nivolumab in 11 clinical trials. Nivolumab pharmacokinetics is linear with a time-varying clearance. A full covariate model was developed to assess covariate effects on pharmacokinetic parameters. Nivolumab clearance and volume of distribution increase with body weight. The final model included the effects of baseline performance status (PS), baseline body weight, and baseline estimated glomerular filtration rate (eGFR), sex, and race on clearance, and effects of baseline body weight and sex on volume of distribution in the central compartment. Sex, PS, baseline eGFR, age, race, baseline lactate dehydrogenase, mild hepatic impairment, tumor type, tumor burden, and programmed death ligand-1 expression had a significant but not clinically relevant (<20%) effect on nivolumab clearance.
authors.affiliation: Bristol-Myers Squibb, Princeton, New Jersey, USA.
authors.forename: G
authors.initials: G
authors.lastname: Bajaj
authors.affiliation: Bristol-Myers Squibb, Princeton, New Jersey, USA.
authors.forename: X
authors.initials: X
authors.lastname: Wang
authors.affiliation: Bristol-Myers Squibb, Princeton, New Jersey, USA.
authors.forename: S
authors.initials: S
authors.lastname: Agrawal
authors.affiliation: Bristol-Myers Squibb, Princeton, New Jersey, USA.
authors.forename: M
authors.initials: M
authors.lastname: Gupta
authors.affiliation: Bristol-Myers Squibb, Princeton, New Jersey, USA.
authors.forename: A
authors.initials: A
authors.lastname: Roy
authors.affiliation: Bristol-Myers Squibb, Princeton, New Jersey, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Feng
mesh_terms: D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D017321:Clinical Trials, Phase I as Topic / Q000706:statistics & numerical data; D017322:Clinical Trials, Phase II as Topic / Q000706:statistics & numerical data; D017326:Clinical Trials, Phase III as Topic / Q000706:statistics & numerical data; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008954:Models, Biological; D015337:Multicenter Studies as Topic / Q000706:statistics & numerical data; D009369:Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000378:metabolism; D000077594:Nivolumab; D061026:Programmed Cell Death 1 Receptor / Q000037:antagonists & inhibitors
chemical_list: D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents; C105992:PDCD1 protein, human; D061026:Programmed Cell Death 1 Receptor; D000077594:Nivolumab