title: Bactericidal/permeability increasing protein gene polymorphism and inflammatory bowel diseases: meta-analysis of five case-control studies.
abstract: OBJECTIVE
  Bactericidal/permeability increasing protein (BPI) gene polymorphisms have been extensively investigated in terms of their associations with inflammatory bowel disease (IBD), with contradictory results. The aim of this meta-analysis was to evaluate associations between BPI gene polymorphisms and the risk of IBD, Crohn's disease (CD), and ulcerative colitis (UC).
  
  
  METHODS
  Eligible studies from PubMed, Embase, and Cochrane library databases were identified.
  
  
  RESULTS
  Ten studies (five CD and five UC) published in five papers were included in this meta-analysis. G645A polymorphism was associated with a decreased risk of UC in allele model, dominant model, and homozygous model.
  
  
  CONCLUSIONS
  Our data suggested that BPI G645A polymorphism was associated with a decreased risk of UC; the BPI G645A polymorphism was not associated with the risk of CD.
authors.affiliation: Department of Gastroenterology, Jining First People's Hospital, No. 6 health Road, Jining, Shandong Province, 272000, China.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Fan
authors.affiliation: Department of Gastroenterology, Jining First People's Hospital, No. 6 health Road, Jining, Shandong Province, 272000, China.
authors.forename: Guoning
authors.initials: G
authors.lastname: Fu
authors.affiliation: Department of Gastroenterology, Jining First People's Hospital, No. 6 health Road, Jining, Shandong Province, 272000, China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Ding
authors.affiliation: Department of Gastroenterology, Jining First People's Hospital, No. 6 health Road, Jining, Shandong Province, 272000, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Lv
authors.affiliation: Department of Gastroenterology, Jining First People's Hospital, No. 6 health Road, Jining, Shandong Province, 272000, China. xhlhy1998@163.com.
authors.forename: Hongyun
authors.initials: H
authors.lastname: Li
mesh_terms: D023181:Antimicrobial Cationic Peptides / Q000235:genetics*; D001798:Blood Proteins / Q000235:genetics*; D016022:Case-Control Studies; D003093:Colitis, Ulcerative / Q000235:genetics; D003424:Crohn Disease / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias
chemical_list: D023181:Antimicrobial Cationic Peptides; D001798:Blood Proteins; C021623:bactericidal permeability increasing protein
keywords: Bactericidal/permeability increasing protein; Crohn’s disease; Inflammatory bowel disease; Polymorphism; Ulcerative colitis