title: [THE FEATURES OF PHARMACOKINETICS ANTIBIOTIC CEFTRIAXONE WITH INTRAVENOUS WAY THAT ARE DEPOSITED IN AUTOLOGOUS ERYTHROCYTES AND LEUKOCYTES OF RABBIT].
abstract: In the experiment on 18 rabbits Сeftriaxone pharmacokinetics after intravenous injection of the medication deposited in autologous erythrocytes and leukocytes were studied. The features of the pharmacokinetics when administered Сeftriaxone in erythrocytes ghost and leukocytes as compared to traditional intravenous drug administration have been determined.It is discussed the possibility of antibiotics transport in the surgical site of infection via cellular carriers in the article. We do the comparative analysis of the main pharmacokinetic parameters of Ceftriaxone in experimental conditions of leukocyte, erythrocyte transport and intravenous way. Based on these results the authors come to the conclusion about the benefits of leukocyte antibiotic transport to the site of surgical infection.
authors.affiliation: Karaganda State Medical University; National Laboratory Astana, Nazarbayev University, Astana, Kazakhstan.
authors.forename: Z
authors.initials: Z
authors.lastname: Yussifov
authors.affiliation: Karaganda State Medical University; National Laboratory Astana, Nazarbayev University, Astana, Kazakhstan.
authors.forename: S
authors.initials: S
authors.lastname: Lokhvitskii
authors.affiliation: Karaganda State Medical University; National Laboratory Astana, Nazarbayev University, Astana, Kazakhstan.
authors.forename: A
authors.initials: A
authors.lastname: Gulyaev
mesh_terms: D061605:Administration, Intravenous; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D002443:Ceftriaxone / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D004337:Drug Carriers; D004912:Erythrocytes; D007962:Leukocytes; D008297:Male; D011817:Rabbits
chemical_list: D000900:Anti-Bacterial Agents; D004337:Drug Carriers; D002443:Ceftriaxone