title: Squamous cell carcinoma antigen (SCCA) is up-regulated during Barrett's carcinogenesis and predicts esophageal adenocarcinoma resistance to neoadjuvant chemotherapy.
abstract: Squamous Cell Carcinoma Antigen (SCCA) is consistently overexpressed in many different solid tumors, and has been associated with both tumor aggressiveness and chemoresistance. No data, however, is currently available on SCCA expression during esophageal Barrett's carcinogenesis, nor on SCCA expression's role on esophageal adenocarcinoma chemoresistance. The SCCA immunohistochemical expression was assessed in a series of 100 biopsy samples covering the whole histological spectrum of Barrett's oncogenesis. Squamous native mucosa was characterized by a moderate to strong cytoplasmic and nuclear SCCA expression in suprabasal, medium, and superficial layers. On the other hand, almost half of the considered lesions did not express SCCA; the other half featured weak to moderate SCCA expression. The relationship between SCCA protein expression and tumor response to neoadjuvant chemotherapy was assessed in 90 esophageal adenocarcinoma specimens (40 biopsy and 50 surgery specimens), stratified according to Mandard tumor regression grade. As observed in other settings, the presence of SCCA expression clustered in the group of tumors characterized by a lower responsiveness to neoadjuvant treatments. The present results suggest an involvement of SCCA in a subset of Barrett-related tumors, and prompt to consider the SCCA-protein expression as response-predictive marker of neoadjuvant therapy in esophageal adenocarcinomas.
authors.affiliation: Department of Medicine (DIMED), Surgical Pathology Unit, University of Padua, Padua, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Fassan
authors.affiliation: Gastroenterology Unit, Istituto Oncologico Veneto, IOV-IRCCS, Padua, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Realdon
authors.affiliation: Department of Medicine (DIMED), Surgical Pathology Unit, University of Padua, Padua, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Vianello
authors.affiliation: Department of Medicine (DIMED), 5th Medical Clinic, University of Padua, Padua, Italy.
authors.forename: Santina
authors.initials: S
authors.lastname: Quarta
authors.affiliation: Department of Surgical, Oncological and Gastroenterological Sciences (DiSCOG), 3rd Surgical Clinic, University of Padua, Padua, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Ruol
authors.affiliation: Esophageal and Digestive Tract Surgical Unit, Veneto Institute of Oncology, IOV-IRCCS, Padua, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Castoro
authors.affiliation: Esophageal and Digestive Tract Surgical Unit, Veneto Institute of Oncology, IOV-IRCCS, Padua, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Scarpa
authors.affiliation: Imperial College London, Department of Surgery and Cancer, Division of Surgery, London, UK.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Zaninotto
authors.affiliation: Department of Medicine (DIMED), Surgical Pathology Unit, University of Padua, Padua, Italy.
authors.forename: Vincenza
authors.initials: V
authors.lastname: Guzzardo
authors.affiliation: Melanoma & Esophageal Oncology Unit, Istituto Oncologico Veneto, IOV-IRCCS, Padua, Italy.
authors.forename: Vanna
authors.initials: V
authors.lastname: Chiarion Sileni
authors.affiliation: Department of Medicine (DIMED), 5th Medical Clinic, University of Padua, Padua, Italy.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Pontisso
authors.affiliation: Department of Medicine (DIMED), Surgical Pathology Unit, University of Padua, Padua, Italy.|Veneto Tumour Registry, Veneto Region, Padua, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Rugge
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology; D000951:Antigens, Neoplasm / Q000096:biosynthesis*; D001471:Barrett Esophagus / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology; D063646:Carcinogenesis; D019008:Drug Resistance, Neoplasm; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D020360:Neoadjuvant Therapy; D012189:Retrospective Studies; D015843:Serpins / Q000096:biosynthesis*; D015854:Up-Regulation
chemical_list: D000951:Antigens, Neoplasm; D015843:Serpins; C051072:squamous cell carcinoma-related antigen
keywords: Barrett’s carcinogenesis; SCCA; esophageal adenocarcinoma; preneoplastic lesions