title: Contribution of fibroblast growth factor 23 to Framingham risk score for identifying subclinical atherosclerosis in Chinese men.
abstract: Fibroblast growth factor 23 (FGF23) was demonstrated to be involved in the occurrence and development of cardiovascular disease (CVD). The goal of the present study was to investigate the relationship between serum FGF23 levels and carotid intima-media thickness (C-IMT) in men with a low-to-moderate CVD risk.
  
  
  
  Subjects with normal kidney function were selected from the Shanghai Obesity Study. Serum FGF23 levels were determined by sandwich enzyme-linked immunosorbent assay. C-IMT was measured by ultrasonography. The Framingham risk score (FRS) was used to assess CVD risk. A total of 392 men with low CVD risk and 372 men with moderate CVD risk were enrolled. The recognition rate of an elevated C-IMT was 85.66% with the combination of a moderate CVD risk and high serum FGF23 levels, which was greater than that with either parameter alone (65.44% and 61.03%, respectively). Subjects with high serum FGF23 levels, and either low or moderate CVD risk, were more likely to have elevated C-IMT than those with low serum FGF23 levels and low CVD risk (P = 0.014 and 0.001, respectively). The serum FGF23 levels were independently and positively associated with C-IMT in subjects with low or moderate CVD risk (both P = 0.007).
  
  
  
  In men with low-to-moderate CVD risk, serum FGF23 levels were associated independently and positively with C-IMT. As a complementary index, serum FGF23 levels strengthen the capacity of the FRS to identify subclinical atherosclerosis.
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China; Shanghai Clinical Center for Diabetes, Shanghai 200233, China; Shanghai Key Clinical Center for Metabolic Disease, Shanghai 200233, China; Shanghai Diabetes Institute, Shanghai 200233, China; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China.
authors.forename: X
authors.initials: X
authors.lastname: Hu
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China; Shanghai Clinical Center for Diabetes, Shanghai 200233, China; Shanghai Key Clinical Center for Metabolic Disease, Shanghai 200233, China; Shanghai Diabetes Institute, Shanghai 200233, China; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China.
authors.forename: X
authors.initials: X
authors.lastname: Ma
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China; Shanghai Clinical Center for Diabetes, Shanghai 200233, China; Shanghai Key Clinical Center for Metabolic Disease, Shanghai 200233, China; Shanghai Diabetes Institute, Shanghai 200233, China; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China; Shanghai Clinical Center for Diabetes, Shanghai 200233, China; Shanghai Key Clinical Center for Metabolic Disease, Shanghai 200233, China; Shanghai Diabetes Institute, Shanghai 200233, China; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China; Shanghai Clinical Center for Diabetes, Shanghai 200233, China; Shanghai Key Clinical Center for Metabolic Disease, Shanghai 200233, China; Shanghai Diabetes Institute, Shanghai 200233, China; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Xiong
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China; Shanghai Clinical Center for Diabetes, Shanghai 200233, China; Shanghai Key Clinical Center for Metabolic Disease, Shanghai 200233, China; Shanghai Diabetes Institute, Shanghai 200233, China; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China.
authors.forename: X
authors.initials: X
authors.lastname: Pan
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China; Shanghai Clinical Center for Diabetes, Shanghai 200233, China; Shanghai Key Clinical Center for Metabolic Disease, Shanghai 200233, China; Shanghai Diabetes Institute, Shanghai 200233, China; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China. Electronic address: yqbao@sjtu.edu.cn.
authors.forename: Y
authors.initials: Y
authors.lastname: Bao
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China; Shanghai Clinical Center for Diabetes, Shanghai 200233, China; Shanghai Key Clinical Center for Metabolic Disease, Shanghai 200233, China; Shanghai Diabetes Institute, Shanghai 200233, China; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China.
authors.forename: W
authors.initials: W
authors.lastname: Jia
mesh_terms: D000328:Adult; D044466:Asian People; D058070:Asymptomatic Diseases; D050197:Atherosclerosis / Q000097:blood* / Q000000981:diagnostic imaging / Q000208:ethnology; D015415:Biomarkers / Q000097:blood; D002340:Carotid Artery Diseases / Q000097:blood* / Q000000981:diagnostic imaging / Q000208:ethnology; D059168:Carotid Intima-Media Thickness; D002681:China / Q000453:epidemiology; D004797:Enzyme-Linked Immunosorbent Assay; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D012307:Risk Factors; D012737:Sex Factors; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; C000717427:FGF23 protein, human; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23
keywords: Carotid intima-media thickness; Fibroblast growth factor 23; Framingham risk score