title: How to manage poor mobilizers for high dose chemotherapy and autologous stem cell transplantation?
abstract: Today, peripheral blood stem cells are the preferred source of stem cells over bone marrow. Therefore, mobilization plays a crutial role in successful autologous stem cell transplantation. Poor mobilization is generally defined as failure to achieve the target level of at least 2×106CD34+cells/kg body weight. There are several strategies to overcome poor mobilization: 1) Larger volume Leukapheresis (LVL) 2) Re-mobilization 3) Plerixafor 4) CM+Plerixafor (P)+G-CSF and 5) Bone Marrow Harvest. In this review, the definitions of successful and poor mobilization are discussed. Management strategies for poor mobilization are defined. The recent research on new agents are included.
authors.affiliation: Department of Hematology, Ankara University Medical School, Cebeci, 06590 Ankara, Turkey. Electronic address: pinar@ataca.tk.
authors.forename: Pinar
authors.initials: P
authors.lastname: Ataca Atilla
authors.affiliation: Department of Hematology, Ankara Ataturk Hospital, Cankaya, 06800 Ankara, Turkey. Electronic address: sulemine.ozturk@yahoo.com.
authors.forename: Sule Mine
authors.initials: SM
authors.lastname: Bakanay Ozturk
authors.affiliation: Department of Hematology, Ankara University Medical School, Cebeci, 06590 Ankara, Turkey. Electronic address: demirer@medicine.ankara.edu.tr.
authors.forename: Taner
authors.initials: T
authors.lastname: Demirer
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D064592:Autografts; D001596:Benzylamines; D000080027:Cyclams; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods*; D006412:Hematopoietic Stem Cells; D006571:Heterocyclic Compounds / Q000627:therapeutic use*; D006801:Humans; D007937:Leukapheresis / Q000379:methods*; D009369:Neoplasms / Q000628:therapy*; D033581:Stem Cell Transplantation
chemical_list: D000970:Antineoplastic Agents; D001596:Benzylamines; D000080027:Cyclams; D006571:Heterocyclic Compounds; D016179:Granulocyte Colony-Stimulating Factor; C088327:plerixafor
keywords: Autologous hematopoietic stem cell transplantation; Chemotherapy; G-CSF; Plerixafor; Poor mobilizers