title: Rust on the Brain from Microbleeds and Its Relevance to Alzheimer Studies: Invited Commentary on Cacciottolo Neurobiology of Aging, 2016.
abstract: Cerebral microbleeds (MB) and small vessel disease (SVD) with congophilic arterial angiopathy (CAA) are increasingly recognized as a variable factor in AD cognitive impairments. This commentary on our recent report on sex-ApoE interactions in MBs published this February, briefly explores three aspects of MBs that could not be fully discussed therein: I, A possible gap between the prevalence of MBs as detected by MRI and post mortem analysis; II, The role of hemoglobin-degradation products in amyloid-attributed neurodegenerative changes; and III, Possible assessment of MB by cerebrospinal fluid (CSF) assays for iron-related markers to better screen patient subgroups for AD interventions.
authors.affiliation: Leonard Davis School of Gerontology, Los Angeles CA, USA.
authors.forename: M
authors.initials: M
authors.lastname: Cacciottolo
authors.affiliation: Leonard Davis School of Gerontology, Los Angeles CA, USA.
authors.forename: T E
authors.initials: TE
authors.lastname: Morgan
authors.affiliation: Leonard Davis School of Gerontology, Los Angeles CA, USA; Department of Neurobiology, Dornsife College, University of Southern California, Los Angeles CA, USA.
authors.forename: C E
authors.initials: CE
authors.lastname: Finch
keywords: Alzheimer disease; CSF heme; Microbleeds; Transgenic mice