title: Recent advancements in the development of anti-tuberculosis drugs.
abstract: Modern chemotherapy has significantly improved patient outcomes against drug-sensitive tuberculosis. However, the rapid emergence of drug-resistant tuberculosis, together with the bacterium's ability to persist and remain latent present a major public health challenge. To overcome this problem, research into novel anti-tuberculosis targets and drug candidates is thus of paramount importance. This review article provides an overview of tuberculosis highlighting the recent advances and tools that are employed in the field of anti-tuberculosis drug discovery. The predominant focus is on anti-tuberculosis agents that are currently in the pipeline, i.e. clinical trials.
authors.affiliation: School of Health Sciences, University of KwaZulu-Natal, Westville, Durban 4001, South Africa.
authors.forename: Sarentha
authors.initials: S
authors.lastname: Chetty
authors.affiliation: School of Health Sciences, University of KwaZulu-Natal, Westville, Durban 4001, South Africa.
authors.forename: Muthusamy
authors.initials: M
authors.lastname: Ramesh
authors.affiliation: School of Health Sciences, University of KwaZulu-Natal, Westville, Durban 4001, South Africa.
authors.forename: Ashona
authors.initials: A
authors.lastname: Singh-Pillay
authors.affiliation: School of Health Sciences, University of KwaZulu-Natal, Westville, Durban 4001, South Africa. Electronic address: soliman@ukzn.ac.za.
authors.forename: Mahmoud E S
authors.initials: ME
authors.lastname: Soliman
mesh_terms: D000995:Antitubercular Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D004269:DNA, Bacterial / Q000737:chemistry / Q000378:metabolism; D055808:Drug Discovery; D024881:Drug Resistance, Bacterial / Q000187:drug effects; D023281:Genomics; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000235:genetics; D014376:Tuberculosis / Q000178:diet therapy* / Q000188:drug therapy
chemical_list: D000995:Antitubercular Agents; D001426:Bacterial Proteins; D004269:DNA, Bacterial
keywords: Drug discovery and development; Drug-resistance; Mycobacterium; Tuberculosis