title: Phospholipids in mitochondrial dysfunction during hemorrhagic shock.
abstract: Energy deficiency plays a key role in the development of irreversible shock conditions. Therefore, identifying mitochondrial functional disturbances during hemorrhagic shock should be considered a prospective direction for studying its pathogenesis. Phospholipid (PL)-dependent mechanisms of mitochondrial dysfunction in the brain (i.e., in the frontal lobes of the cerebral hemispheres and medulla oblongata) and liver, which, when damaged, leads to an encephalopathy, are examined in this review. These mechanisms show strong regional specificity. Analyzing the data presented in this review suggests that the basis for mitochondrial functional disturbances is cholinergic hyperactivation, accompanied by a choline deficiency and membrane phosphatidylcholine (PC) depletion. Stabilization of the PL composition in mitochondrial membranes using "empty" PC liposomes could be one of the most important methods for eliminating energy deficiency during massive blood loss.
authors.affiliation: Laboratory of nanopathology and biomedical nanotechnologies, Institute of General Pathology und Pathophysiology, Baltijskaja str., 8, 125315, Moscow, Russia. lesk-galina@rambler.ru.
authors.forename: Galina F
authors.initials: GF
authors.lastname: Leskova
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000737:chemistry; D002796:Choline Deficiency; D006801:Humans; D028361:Mitochondrial Diseases / Q000209:etiology* / Q000503:physiopathology; D010713:Phosphatidylcholines / Q000172:deficiency / Q000627:therapeutic use; D010743:Phospholipids / Q000378:metabolism*; D012771:Shock, Hemorrhagic / Q000150:complications*
chemical_list: D010713:Phosphatidylcholines; D010743:Phospholipids
keywords: Hemorrhagic shock; Mitochondrial membranes; Phospholipids