title: Switching Apoptosis to Ferroptosis: Metal-Organic Network for High-Efficiency Anticancer Therapy.
abstract: Discovering advanced materials for regulating cell death is of great importance in the development of anticancer therapy. Herein, by harnessing the recently discovered oxidative stress regulation ability of p53 and the Fenton reaction inducing capability of metal-organic network (MON), MON encapsulated with p53 plasmid (MON-p53) was designed to eradicate cancer cells via ferroptosis/apoptosis hybrid pathway. After confirming the detailed mechanism of MON-p53 in evoking ferroptosis, we further discovered that MON-p53 mediated a "bystander effect" to further sensitize cancer cells toward the MON-p53 induced ferroptosis. A 75-day anticancer experiment indicated that MON-p53 treatment not only suppressed the tumor growth but also prolonged the life-span of tumor bearing mice. Owing to its ability to promote intracellular oxidative stress, MON-p53 decreased the blood metastasis, lung metastasis, and liver metastasis. As a consequence, discovering methods to induce cell ferroptosis would provide a new insight in designing anticancer materials.
authors.affiliation: Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University , Wuhan 430072, P. R. China.|Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials; Key Laboratory for the Green Preparation and Application of Functional Materials of Ministry of Education, Hubei University , Wuhan, Hubei 430062, P. R. China.
authors.forename: Di-Wei
authors.initials: DW
authors.lastname: Zheng
authors.affiliation: Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University , Wuhan 430072, P. R. China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Lei
authors.affiliation: Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University , Wuhan 430072, P. R. China.
authors.forename: Jing-Yi
authors.initials: JY
authors.lastname: Zhu
authors.affiliation: Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University , Wuhan 430072, P. R. China.
authors.forename: Jin-Xuan
authors.initials: JX
authors.lastname: Fan
authors.affiliation: Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University , Wuhan 430072, P. R. China.
authors.forename: Chu-Xin
authors.initials: CX
authors.lastname: Li
authors.affiliation: Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials; Key Laboratory for the Green Preparation and Application of Functional Materials of Ministry of Education, Hubei University , Wuhan, Hubei 430062, P. R. China.
authors.forename: Cao
authors.initials: C
authors.lastname: Li
authors.affiliation: Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials; Key Laboratory for the Green Preparation and Application of Functional Materials of Ministry of Education, Hubei University , Wuhan, Hubei 430062, P. R. China.
authors.forename: Zushun
authors.initials: Z
authors.lastname: Xu
authors.affiliation: Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University , Wuhan 430072, P. R. China.
authors.forename: Si-Xue
authors.initials: SX
authors.lastname: Cheng
authors.affiliation: Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University , Wuhan 430072, P. R. China.
authors.forename: Xian-Zheng
authors.identifier: 0000-0001-6242-6005
authors.initials: XZ
authors.lastname: Zhang
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects*; D016923:Cell Death; D045744:Cell Line, Tumor; D016158:Genes, p53; D015316:Genetic Therapy; D006801:Humans; D000073396:Metal-Organic Frameworks / Q000008:administration & dosage* / Q000494:pharmacology; D049329:Nanostructures; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D018384:Oxidative Stress / Q000187:drug effects; D010316:Particle Size; D010957:Plasmids; D059808:Polyphenols / Q000737:chemistry*; D013499:Surface Properties; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: D000970:Antineoplastic Agents; D000073396:Metal-Organic Frameworks; D059808:Polyphenols; D016159:Tumor Suppressor Protein p53
keywords: Ferroptosis; anticancer; fenton reaction; nanomaterials; tea polyphenol