title: Transient Helicity: Fuel-Driven Temporal Control over Conformational Switching in a Supramolecular Polymer.
abstract: Synthetic manifestations of supramolecular chirality have extensively drawn inspiration from naturally occurring systems. Even though in biological systems conformational changes are dissipative, synthetic systems that change conformation under non-equilibrium conditions have still not been established. Herein, we attempt to alleviate this scenario by reporting a synthetic supramolecular system that undergoes temporal changes in its helical conformation as an active system at the expense of a biologically relevant chemical fuel, ATP. Use of enzymes working in tandem provides transient and switchable helices with modular lifetime and stereomutation rates.
authors.affiliation: Supramolecular Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Jakkur, Bangalore, 560064, India.
authors.forename: Shikha
authors.initials: S
authors.lastname: Dhiman
authors.affiliation: Supramolecular Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Jakkur, Bangalore, 560064, India.
authors.forename: Ankit
authors.initials: A
authors.lastname: Jain
authors.affiliation: Supramolecular Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Jakkur, Bangalore, 560064, India.
authors.forename: Subi J
authors.initials: SJ
authors.lastname: George
keywords: chirality; conformational switching; supramolecular chemistry; transient helicity