title: Longitudinal analysis of living donor kidney transplant rates in pediatric candidates in the United States.
abstract: Among adults, living donor kidney transplant rates began declining in the United States after 2004 but whether a similar decline is occurring in the pediatric candidates has not been well studied. Share 35, a change in allocation rules implemented in October of 2005, may also have influenced rates of living donation. We sought to determine whether a decline in rates was occurring in pediatric candidates and whether the Share 35 program was the cause of the decline. All children listed for a kidney transplant or transplanted with a living donor without listing between 1996 and 2011 were identified in the United States (N=14 911) of which 6046 had received a living donor transplant during follow-up. Kaplan-Meier analysis showed a decline in living donor rates in candidates listed after 2001. Logistic regression analysis for living donor kidney transplantation confirmed the timing of the drop but also showed that changes in candidate demographics and center listing practices were impacting rates. A large drop in parental donation was the main cause for the drop. The rate of living donor transplant among pediatric candidates declined after 2001 predating by 4 years the implementation of Share 35, suggesting that factors other than changes in allocation rules are responsible for the decline.
authors.affiliation: Division of Nephrology, University of Virginia, Charlottesville, VA, USA.
authors.forename: Douglas S
authors.initials: DS
authors.lastname: Keith
authors.affiliation: Division of Nephrology, University of Virginia, Charlottesville, VA, USA.
authors.forename: Gayle
authors.initials: G
authors.lastname: Vranic
authors.affiliation: Division of Pediatric Nephrology, University of Virginia, Charlottesville, VA, USA.
authors.forename: John
authors.initials: J
authors.lastname: Barcia
authors.affiliation: Division of Pediatric Nephrology, University of Virginia, Charlottesville, VA, USA.
authors.forename: Victoria
authors.initials: V
authors.lastname: Norwood
authors.affiliation: Division of Nephrology, University of Virginia, Charlottesville, VA, USA.
authors.forename: Angie
authors.initials: A
authors.lastname: Nishio-Lucar
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D016208:Databases, Factual; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D007676:Kidney Failure, Chronic / Q000401:mortality / Q000601:surgery*; D016030:Kidney Transplantation; D019520:Living Donors; D008137:Longitudinal Studies; D008297:Male; D018579:Patient Selection; D010372:Pediatrics / Q000379:methods; D012044:Regression Analysis; D013997:Time Factors; D009927:Tissue and Organ Procurement / Q000379:methods* / Q000592:standards; D014481:United States; D014850:Waiting Lists
keywords: Share 35 program; candidate demographics; donor relationship; living donor kidney transplantation; pediatric candidates; waiting list