title: Metabolic parameters in diabetic neuropathic patients after treatment with pregabalin.
abstract: OBJECTIVE
  To assess metabolic parameters in patients with diabetic peripheral neuropathy (DPN) before and after 3 months treatment with a flexible dose pregabalin.
  
  
  METHODS
  This is a prospective clinical trial. The metabolic parameters observed and recorded after 3 months treatment with a flexible dose pregabalin (n=331).
  
  
  RESULTS
  The lipid profile parameters were significantly improved after treatment, total cholesterol, TC (P<0.01, 95% CI, 25.91-41.98), low-density lipoprotein, LDL (P<0.01, 95% CI, 21.11-34.80), triglycerides, TG (P<0.001, 95% CI, 56.43-79.26), all the three parameters significantly decreased while high-density lipoprotein, HDL, significantly increased (P<0.05, 95% CI, -8.61 to -5.51). Microalbumin mean was 16±1.39 before treatment versus 6.5±0.59 after treatment. Glycolated hemoglobin, HbA1c mean was 9.6±0.099 before pregabalin therapy and 7.6 ±0.06 after. BMI mean was 33.5±0.45 before versus 31.1±0.33 after (P<0.001). HbA1C was positively correlated with DPN severity before treatment (r=0.18, P<0.01). Same results were observed with weight and waist circumference (r=0.17, P<0.01, r=0.14, P<0.05 respectively). Oral anti diabetic medications (OAD) were also positively correlated to DPN severity before treatment (r=0.115, P<0.05).
  
  
  CONCLUSIONS
  Prompt treatment of DPN has a significant effect on the metabolic parameters.
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Taibah University, Universities Road, Madinah, PO Box: 344, Saudi Arabia. Electronic address: DROLFATZEID@GMAIL.COM.
authors.forename: O A
authors.initials: OA
authors.lastname: Abou Zeid
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Taibah University, Universities Road, Madinah, PO Box: 344, Saudi Arabia; Department of Internal Medicine, Faculty of Medicine, Alazhar University, Egypt.
authors.forename: N Y
authors.initials: NY
authors.lastname: Elkhouly
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Taibah University, Universities Road, Madinah, PO Box: 344, Saudi Arabia.
authors.forename: E N
authors.initials: EN
authors.lastname: Osman
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Taibah University, Universities Road, Madinah, PO Box: 344, Saudi Arabia.
authors.forename: M H
authors.initials: MH
authors.lastname: Youssef
mesh_terms: D001786:Blood Glucose / Q000032:analysis; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D003929:Diabetic Neuropathies / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism*; D005260:Female; D005500:Follow-Up Studies; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D008055:Lipids / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D000069583:Pregabalin / Q000627:therapeutic use*; D011379:Prognosis; D011446:Prospective Studies; D055105:Waist Circumference
chemical_list: D001786:Blood Glucose; D002121:Calcium Channel Blockers; D006442:Glycated Hemoglobin; D008055:Lipids; D000069583:Pregabalin; C517652:hemoglobin A1c protein, human
keywords: Diabetes; Diabetic peripheral neuropathy (DPN); Metabolic parameters; Pregabalin