title: Fibro/adipogenic progenitors safeguard themselves: a novel mechanism to reduce fibrosis is discovered.
abstract: PDGFRα regulates several cellular processes, and exacerbated PDGF signaling cause fibrosis in different tissues. Different research groups have shown that fibro/adipogenic progenitors (FAPs) are responsible for pathological fibrosis found in skeletal muscle disorders. Rando's Lab describes that an intronic polyadenylation of Pdgfra regulates FAPs activity, and therefore fibrosis. This discovery opens a new potential target for treating fibrosis.
authors.affiliation: Centro de Envejecimiento y Regeneración, CARE Chile UC y Departmento de Biología Celular y Molecular, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile.
authors.forename: Osvaldo
authors.initials: O
authors.lastname: Contreras
authors.affiliation: Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Libertador Bernardo O'Higgins 340, Postal Code 8331150, Santiago, Chile. ebrandan@bio.puc.cl.
authors.forename: Enrique
authors.identifier: http://orcid.org/0000-0002-6820-5059
authors.initials: E
authors.lastname: Brandan
keywords: Fibro/adipogenic progenitors; Fibrosis; Muscle regeneration; PDGFRα; Polyadenylation