title: Relationship between resting state functional magnetic resonance imaging and memory function in mesial temporal lobe epilepsy.
abstract: OBJECTIVE
  To study memory impairment mechanisms of the medial temporal lobe epilepsy (MTLE) by analyzing the functional connectivity (FC) through resting state functional magnetic resonance imaging (rs-fMRI).
  
  
  METHODS
  Rs-fMRI data were acquired from 13 patients with left MTLE and 11 patients with right MTLE. Another 13 healthy volunteers were selected as controls. The altered FC pattern between the unilateral hippocampus and other regions of the brain in MTLE patients was compared to that of the normal control group. Then the correlation between the strength of FC and the clinical memory scale scores in patients with MTLE was determined.
  
  
  RESULTS
  The scores of the following check points of MTLE patients including point to memory, recognition of nonsense figure, associative learning, the image free recall, portrait characteristic recall and memory quotient were significantly lower than those in the normal group (all P<0.05). The scores of point to memory and recognition of nonsense figure were different between R-MTLE and L-MTLE patients. Different correlations between the strength of FC and the clinical memory scale scores were detected between R-MTLE and L-MTLE patients.
  
  
  CONCLUSIONS
  The memory function of patients with MTLE was impaired. Patients with L-MTLE showed lower score on pure verbal memory test and those with R-MTLE showed weaker performance on pure visual memory test. Patients with MTLE showed extensive abnormal FC between hippocampus and particular encephalic regions.
authors.affiliation: Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, China.
authors.forename: Shenggen
authors.initials: S
authors.lastname: Chen
authors.affiliation: The Affiliated Hospital of Jinggangshan University, Ji'an, Jiangxi 343000, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, China. Electronic address: huapin_huang1@outlook.com.
authors.forename: Huapin
authors.initials: H
authors.lastname: Huang
authors.affiliation: Departments of Neurology and Geriatrics, Fujian Medical University Union Hospital, Fujian Key Laboratory of Molecular Neurology, Fuzhou, Fujian 350001, China. Electronic address: wanhui_lin2@outlook.com.
authors.forename: Wanhui
authors.initials: W
authors.lastname: Lin
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D001931:Brain Mapping; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000000981:diagnostic imaging* / Q000503:physiopathology* / Q000523:psychology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology*; D009434:Neural Pathways / Q000000981:diagnostic imaging / Q000503:physiopathology; D009483:Neuropsychological Tests; D012146:Rest
keywords: Clinical memory scale (CMS); Functional connection (FC); Hippocampus; MTLE; Resting-state fMRI (rs-fMRI)