title: Serotonin in Space: Understanding Single Fibers.
abstract: All brain regions contain fibers that store and release 5-hydroxytryptamine (5-HT, serotonin). Since these fibers often do not have well-defined trajectories, most studies have focused on their overall densities, a measure that can be associated with local 5-HT tone in heathy and diseased brains. However, the observed fiber densities are the consequence of the behavior of single fibers. Evidence is presented as to why understanding single-fiber trajectories is important for basic and clinical neuroscience. In particular, serotonergic fibers can be viewed as natural, readily detectable stochastic probes that sample the invisible microarchitecture of brain tissue.
authors.affiliation: Department of Psychological and Brain Sciences, University of California , Santa Barbara, California 93106-9660, United States.
authors.forename: Skirmantas
authors.identifier: 0000-0003-0129-1463
authors.initials: S
authors.lastname: Janušonis
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D009412:Nerve Fibers / Q000378:metabolism*; D059326:Serotonergic Neurons / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism*
chemical_list: D012701:Serotonin
keywords: 5-hydroxytryptamine; density; fibers; random walk; stochastic methods