title: Primary retroperitoneal seminoma - embryology, histopathology and treatment particularities.
abstract: BACKGROUND
  Retroperitoneal seminoma is a very rare form of cancer, with embryological origin represented by primordial germ cells from the urogenital ridges left behind during the fetal development. Extragenital germ cell tumors can also occur in the mediastinum or the pineal gland. The aim of this paper is to outline the particularities and draw embryological, histopatological and treatment conclusions regarding extragonadal germ cell tumors.
  
  
  METHODS
  A 43-year-old patient without any additional pathology was admitted for anemia of unknown etiology. The clinical examination revealed through deep abdominal palpation a mass in the left flank, and normal testes. Thoraco-abdomino-pelvic computed tomography (CT) scan showed a large retroperitoneal tumor adjacent to the great vessels in the left lumbo-iliac region. The blood work revealed just a low hemoglobin and hematocrit. With the established diagnosis of retroperitoneal tumor, radical surgical removal was decided. During the surgery, we were required to dissect a large solid encapsulated tumor mass from the aorta and the common iliac artery, starting at the renal pedicle all the way to the left iliac bifurcation. The surgical access was obtained through a transperitoneal left subcostal incision prolonged pararectally. Histopathological and immunohistochemical studies revealed a seminoma of the usual type. After the histological findings, the patient's tumor markers were investigated (LDH - lactate dehydrogenase, βHCG - beta-human chorionic gonadotropin, αFP - alpha-fetoprotein), all values being within normal ranges. In addition, the left testicle was thoroughly reexamined, clinically, through ultrasound and magnetic resonance imaging (MRI) scans, and no abnormalities were observed. After the surgery, the patient followed three courses of chemotherapy (BEP - Bleomycin, Etoposide and Cisplatin).
  
  
  RESULTS
  The CT scan done 24 months after surgery found no signs of local or distant tumor recurrence. The patient entered a follow-up schedule consisting of periodical clinical, serological and imagistic evaluations.
  
  
  CONCLUSIONS
  Primary retroperitoneal seminoma is a rare entity that must be taken into account when treating a retroperitoneal tumor. It develops out of the urogenital ridge, while the testes are normal. Thorough testicular evaluation (clinical, ultrasound and serum markers) is mandatory in all retroperitoneal tumors. The histopathological analysis is crucial for an accurate diagnosis and a proper management strategy. Through radical surgery and chemotherapy, the patients that are diagnosed prior to massive visceral metastatic dissemination can be cured.
authors.affiliation: "Fundeni" Urological Surgery Discipline, 3rd Department, Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, Center for Uronephrology and Renal Transplantation, "Fundeni" Clinical Institute, Bucharest, Romania; cgingu@gmail.com.
authors.forename: Constantin Virgil
authors.initials: CV
authors.lastname: Gîngu
authors.forename: Mihaela
authors.initials: M
authors.lastname: Mihai
authors.forename: Cătălin
authors.initials: C
authors.lastname: Baston
authors.forename: Mugurel Alexandru
authors.initials: MA
authors.lastname: Crăsneanu
authors.forename: Alexandru Vladimir
authors.initials: AV
authors.lastname: Dick
authors.forename: Vlad
authors.initials: V
authors.lastname: Olaru
authors.forename: Ioanel
authors.initials: I
authors.lastname: Sinescu
mesh_terms: D000328:Adult; D006801:Humans; D008297:Male; D012186:Retroperitoneal Neoplasms / Q000196:embryology / Q000473:pathology / Q000628:therapy; D018239:Seminoma / Q000196:embryology / Q000473:pathology / Q000628:therapy; D013736:Testicular Neoplasms / Q000196:embryology / Q000473:pathology / Q000628:therapy