title: Vitamin D in Saudi Arabia: Prevalence,distribution and disease associations.
abstract: More than 33 years have passed since the first paper highlighting vitamin D deficiency as a public health concern in Saudi Arabia was published in 1983. Despite "early" detection,it wasn't until the year 2010 where the interest in vitamin D research grew exponentially worldwide and was finally visible in Saudi clinical and academic areas. Since then,many landmark studies have been generated with regards to the physiologic functions of vitamin D,both skeletal and extra-skeletal. This review is limited to the prevalence,distribution A systematic review on the prevalence studies done in KSA from 2011 to 2016 was done and revealed that the prevalence of vitamin D deficiency (<50nmol/l) in Saudi Arabia among different populations (adults,children and adolescents,newborns and pregnant/lactating women) is 81.0% (Confidence Interval 95% 68.0-90.0),in line with most neighboring Gulf countries. Vitamin D deficiency in KSA has been mostly associated with bone and insulin-resistant diseases but limited data are available to prove causality. In conclusion,there is a need to develop local consensus guidelines that will identify candidates for screening,monitoring and treating those who are at most risk for vitamin D deficiency complications.
authors.affiliation: Biomarkers Research Program, Biochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia; Prince Mutaib Chair for Biomarkers of Osteoporosis, Biochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia. Electronic address: aldaghri2011@gmail.com.
authors.forename: Nasser M
authors.initials: NM
authors.lastname: Al-Daghri
mesh_terms: D000293:Adolescent; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000150:complications / Q000453:epidemiology*; D002648:Child; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000097:blood / Q000453:epidemiology*; D005260:Female; D050723:Fractures, Bone / Q000097:blood / Q000150:complications / Q000453:epidemiology*; D006331:Heart Diseases / Q000097:blood / Q000150:complications / Q000453:epidemiology*; D006801:Humans; D007774:Lactation / Q000502:physiology; D017410:Practice Guidelines as Topic; D011247:Pregnancy; D015995:Prevalence; D012529:Saudi Arabia / Q000453:epidemiology; D012737:Sex Factors; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood / Q000150:complications / Q000453:epidemiology*
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: Prevalence; Saudi Arabia; Vitamin D; Vitamin D related-diseases