title: Impact of influenza in the post-pandemic phase: Clinical features in hospitalized patients with influenza A (H1N1) pdm09 and H3N2 viruses, during 2013 in Santa Fe, Argentina.
abstract: It is important to characterize the clinical and epidemiological pattern of the influenza A (H1N1) pdm09 virus and compare it with influenza A (H3N2) virus, as surveyed in just a few studies, in order to contribute to the implementation and strengthening of influenza control and prevention strategies. The aims in this study were to describe influenza clinical and epidemiological characteristics in hospitalized patients, caused by influenza A (H1N1)pdm09 and influenza A (H3N2) viruses during 2013, in Santa Fe, Argentina. A retrospective study was conducted over 2013 among hospitalized patients with laboratory-confirmed influenza diagnosis. In contrast to patients with influenza A (H3N2) (20.5%), a higher proportion of hospitalizations associated with influenza H1N1pdm were reported among adults aged 35-65 years (42.8%). Of all patients, 73.6% had an underlying medical condition. Hospitalized patients with H1N1pdm were subject to 2.6 (95%CI, 1.0-6.8) times higher risk of severity, than those hospitalized with influenza A (H3N2). This results demonstrate the impact in the post-pandemic era of H1N1pdm virus, with increased risk of severe disease, in relation to H3N2 virus, both viruses co-circulating during 2013.
authors.affiliation: Instituto Nacional Enfermedades Respiratorias "Dr. Emilio Coni", Santa Fe, Argentina.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Kusznierz
authors.affiliation: Instituto Nacional Enfermedades Respiratorias "Dr. Emilio Coni", Santa Fe, Argentina.
authors.forename: Cudós
authors.initials: C
authors.lastname: Carolina
authors.affiliation: Instituto Nacional Enfermedades Respiratorias "Dr. Emilio Coni", Santa Fe, Argentina.
authors.forename: Rudi Juan
authors.initials: RJ
authors.lastname: Manuel
authors.affiliation: Centro de Especialidades Médicas de Rosario, Santa Fe, Argentina.
authors.forename: Lejona
authors.initials: L
authors.lastname: Sergio
authors.affiliation: Hospital J. B Iturraspe, Santa Fe, Argentina.
authors.forename: Ortellao
authors.initials: O
authors.lastname: Lucila
authors.forename: Befani
authors.initials: B
authors.lastname: Julio
authors.affiliation: Dirección Provincial de Promoción y Protección de la Salud, Ministerio de Salud, Santa Fe, Argentina.
authors.forename: Villani
authors.initials: V
authors.lastname: Mirta
authors.affiliation: Dirección Provincial de Promoción y Protección de la Salud, Ministerio de Salud, Santa Fe, Argentina.
authors.forename: Morana
authors.initials: M
authors.lastname: Pedro
authors.affiliation: Hospital J. M Cullen, Santa Fe, Argentina.
authors.forename: Morera
authors.initials: M
authors.lastname: Graciana
authors.affiliation: Dirección Provincial de Promoción y Protección de la Salud, Ministerio de Salud, Santa Fe, Argentina.
authors.forename: Uboldi
authors.initials: U
authors.lastname: Andrea
authors.affiliation: Instituto Nacional Enfermedades Respiratorias "Dr. Emilio Coni", Santa Fe, Argentina.
authors.forename: Zerbini
authors.initials: Z
authors.lastname: Elsa
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001118:Argentina / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006760:Hospitalization; D006801:Humans; D007223:Infant; D053118:Influenza A Virus, H1N1 Subtype / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification; D053122:Influenza A Virus, H3N2 Subtype / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification; D007251:Influenza, Human / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control / Q000821:virology; D008297:Male; D008875:Middle Aged; D058873:Pandemics; D016133:Polymerase Chain Reaction; D012189:Retrospective Studies; D012720:Severity of Illness Index; D055815:Young Adult
keywords: influenza A (H1N1) pdm09; influenza A (H3N2); post-pandemic phase