title: Exploring the Bioactive Terpenoid Content of an Algerian Plant of the Genus Pulicaria: The ent-Series of Asteriscunolides.
abstract: Chemical analysis of the chloroform extract of the aerial parts of the Algerian plant Pulicaria undulata exhibiting anti-inflammatory activity resulted in the isolation of 10 new humulene sesquiterpenoids, 1-10, belonging to the asteriscunolide family of compounds. The structure and relative configuration have been defined by NMR data, whereas the absolute configuration has been established by ECD analysis. Compounds 1-10 include enantiomers of the known asteriscunolides A-D and tetrahydroasteriscunolide previously reported from the genera Asteriscus and Nauplius. Compounds 1 and 10 showed in vitro anti-inflammatory activity by inhibiting heat-induced albumin denaturation with IC50values of 23.76 and 220.42 μM.
authors.affiliation: Istituto di Chimica Biomolecolare, CNR , Via Campi Flegrei 34, 80078 Pozzuoli (Naples), Italy.|Unité de Recherche: Valorisation des Ressources Naturelles, Molécules Bioactives et Analyses Physicochimiques et Biologiques (VARENBIOMOL), Université Frères Mentouri, Constantine , Route de Aïn El Bey, 25 000 Constantine, Algérie.
authors.forename: Manel
authors.initials: M
authors.lastname: Boumaraf
authors.affiliation: Istituto di Chimica Biomolecolare, CNR , Via Campi Flegrei 34, 80078 Pozzuoli (Naples), Italy.
authors.forename: Marianna
authors.initials: M
authors.lastname: Carbone
authors.affiliation: Istituto di Chimica Biomolecolare, CNR , Via Campi Flegrei 34, 80078 Pozzuoli (Naples), Italy.
authors.forename: M Letizia
authors.initials: ML
authors.lastname: Ciavatta
authors.affiliation: Laboratoire de Synthèse Organique, Modélisation et Optimisation des Procédés, Université Badji Mokhtar de Annaba , Annaba, Algérie.
authors.forename: Samira
authors.initials: S
authors.lastname: Benyahia
authors.affiliation: Laboratoire de Biologie et Environnement, Faculté des Sciences de la Nature et de la Vie, Université des Frères Mentouri, Constantine , 25 000 Constantine, Algérie.
authors.forename: Souad
authors.initials: S
authors.lastname: Ameddah
authors.affiliation: Laboratoire de Biologie et Environnement, Faculté des Sciences de la Nature et de la Vie, Université des Frères Mentouri, Constantine , 25 000 Constantine, Algérie.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Menad
authors.affiliation: Unité de Recherche: Valorisation des Ressources Naturelles, Molécules Bioactives et Analyses Physicochimiques et Biologiques (VARENBIOMOL), Université Frères Mentouri, Constantine , Route de Aïn El Bey, 25 000 Constantine, Algérie.
authors.forename: Samir
authors.initials: S
authors.lastname: Benayache
authors.affiliation: Unité de Recherche: Valorisation des Ressources Naturelles, Molécules Bioactives et Analyses Physicochimiques et Biologiques (VARENBIOMOL), Université Frères Mentouri, Constantine , Route de Aïn El Bey, 25 000 Constantine, Algérie.
authors.forename: Fadila
authors.initials: F
authors.lastname: Benayache
authors.affiliation: Istituto di Chimica Biomolecolare, CNR , Via Campi Flegrei 34, 80078 Pozzuoli (Naples), Italy.
authors.forename: Margherita
authors.identifier: 0000-0002-9532-4555
authors.initials: M
authors.lastname: Gavagnin
mesh_terms: D019659:Asteraceae / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D000081222:Monocyclic Sesquiterpenes; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification*; D052587:Pulicaria / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*; D013729:Terpenes / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D007783:Lactones; D000081222:Monocyclic Sesquiterpenes; D010936:Plant Extracts; D012717:Sesquiterpenes; D013729:Terpenes; C449600:asteriscunolide D; C042686:humulene