title: Vitamin D status among long-term survivors of testicular cancer.
abstract: A correlation between disturbances in hormone levels and the onset of metabolic disorders has been reported in long-term survivors of testicular cancer (TC).We evaluated serum vitamin D levels and other biological parameters in a consecutive series of 61 long-term (≥3 years) unilateral TC survivors with a median a follow-up of 4 years and in a cohort of healthy males. Deficient vitamin D levels were observed in 10 (17%) of the 58 long-term unilateral TC survivors but were not reported in healthy males (p=.019, Fisher test). Median vitamin D levels were 18.6 ug/L in 58 assessable TC survivors and 23.6 ug/L in 40 healthy males (p=.031). In univariate logistic regression analysis, TC diagnosis was associated with inadequate levels of vitamin D (p=.047). Vitamin D levels were lower when follow-up was > 10 years, albeit this difference was not statistically significant (p=.074). Long-term (especially > 10 years) TC survivors may have difficulty maintaining optimal vitamin D levels. Larger studies are needed to better characterize vitamin D status and possible correlations with premature hormonal aging reported in long-term TC survivors.
authors.affiliation: Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, 40 I-47014 Meldola, FC, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Schepisi
authors.affiliation: Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, 40 I-47014 Meldola, FC, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: De Padova
authors.affiliation: Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, 40 I-47014 Meldola, FC, Italy.
authors.forename: Emanuela
authors.initials: E
authors.lastname: Scarpi
authors.affiliation: Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, 40 I-47014 Meldola, FC, Italy.
authors.forename: Cristian
authors.initials: C
authors.lastname: Lolli
authors.affiliation: Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, 40 I-47014 Meldola, FC, Italy.
authors.forename: Giorgia
authors.initials: G
authors.lastname: Gurioli
authors.affiliation: Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, 40 I-47014 Meldola, FC, Italy.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Menna
authors.affiliation: Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, 40 I-47014 Meldola, FC, Italy.
authors.forename: Salvatore L
authors.initials: SL
authors.lastname: Burgio
authors.affiliation: Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, 40 I-47014 Meldola, FC, Italy.
authors.forename: Lorena
authors.initials: L
authors.lastname: Rossi
authors.affiliation: Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, 40 I-47014 Meldola, FC, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Gallà
authors.affiliation: Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, 40 I-47014 Meldola, FC, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Casadio
authors.affiliation: Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, 40 I-47014 Meldola, FC, Italy.
authors.forename: Samanta
authors.initials: S
authors.lastname: Salvi
authors.affiliation: Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, 40 I-47014 Meldola, FC, Italy.
authors.forename: Vincenza
authors.initials: V
authors.lastname: Conteduca
authors.affiliation: Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, 40 I-47014 Meldola, FC, Italy.
authors.forename: Ugo
authors.initials: U
authors.lastname: De Giorgi
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers; D000073116:Cancer Survivors; D016022:Case-Control Studies; D003131:Combined Modality Therapy; D015897:Comorbidity; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009373:Neoplasms, Germ Cell and Embryonal / Q000097:blood / Q000175:diagnosis / Q000401:mortality / Q000628:therapy; D012307:Risk Factors; D013736:Testicular Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000401:mortality* / Q000628:therapy; D014807:Vitamin D / Q000097:blood*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D014807:Vitamin D
keywords: 25-hydroxyvitamin D; germ cell tumor; hypogonadism; testicular cancer survivors; testosterone