title: The effect of smoking on placental pendrin expression.
abstract: Pendrin is important for transport of iodine across the placenta. Thiocyanate coming from cigarette is a competitive inhibitor of iodine transport. We aimed to evaluate the pendrin immunostaining intensity in placentas of smoker and non-smoker women. Placental tissues from 61 women, of which 28 were in smoking, and 33 were in non-smoking group were evaluated by immunohistochemical staining. Positive immunostaining was evaluated using a semiquantitative score: 0, negative; +, mild; ++, moderate; and +++, intense. Birth weight was significantly lower in the smoker group (p = 0.024). There was a negative correlation between birth weight and intensity of placental pendrin immunostaining in the smoker group (r = -0.44, p = 0.02). Placentas of the smoking women showed significantly higher immunostaining with pendrin than the control group (p = 0.006). Thiocyonate coming from cigarettes may competitively inhibit pendrin mediated iodine transport in the placenta and adversely affect foetal development by this mechanism.
authors.affiliation: a Department of Obstetrics and Gynaecology , School of Medicine, Abant Izzet Baysal University, Golkoy Kampusu, Golkoy Yerleskesi , Bolu , Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Karatas
authors.affiliation: b Department of Medical Pathology , School of Medicine, Duzce University, Merkez Yerleskesi , Konuralp , Duzce , Turkey.
authors.forename: Havva
authors.initials: H
authors.lastname: Erdem
authors.affiliation: c Department of Paediatrics , School of Medicine, Abant Izzet Baysal University, Golkoy Kampusu, Golkoy Yerleskesi , Bolu , Turkey.
authors.forename: Zehra
authors.initials: Z
authors.lastname: Karatas
authors.affiliation: a Department of Obstetrics and Gynaecology , School of Medicine, Abant Izzet Baysal University, Golkoy Kampusu, Golkoy Yerleskesi , Bolu , Turkey.
authors.forename: Tulay
authors.initials: T
authors.lastname: Ozlu
authors.affiliation: d Department of Obstetrics and Gynaecology , School of Medicine, Gaziosmanpasa University, Sevki Erek Yerleskesi , Tokat , Turkey.
authors.forename: Bulent
authors.initials: B
authors.lastname: Cakmak
mesh_terms: D000328:Adult; D001724:Birth Weight; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007231:Infant, Newborn; D007455:Iodine / Q000378:metabolism; D026901:Membrane Transport Proteins / Q000378:metabolism*; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D012189:Retrospective Studies; D012907:Smoking / Q000009:adverse effects* / Q000378:metabolism; D000076988:Sulfate Transporters; D013861:Thiocyanates / Q000633:toxicity
chemical_list: D026901:Membrane Transport Proteins; C085609:SLC26A4 protein, human; D000076988:Sulfate Transporters; D013861:Thiocyanates; D007455:Iodine
keywords: Pendrin; placenta; smoking; thiocyanate