title: The pre-existing population of 5S rRNA effects p53 stabilization during ribosome biogenesis inhibition.
abstract: Pre-ribosomal complex RPL5/RPL11/5S rRNA (5S RNP) is considered the central MDM2 inhibitory complex that control p53 stabilization during ribosome biogenesis inhibition. Despite its role is well defined, the dynamic of 5S RNP assembly still requires further characterization. In the present work, we report that MDM2 inhibition is dependent by a pre-existing population of 5S rRNA.
authors.affiliation: Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, S. Orsola Hospital, 40138, Bologna, Italy.
authors.forename: Carmine
authors.initials: C
authors.lastname: Onofrillo
authors.affiliation: Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, S. Orsola Hospital, 40138, Bologna, Italy.
authors.forename: Alice
authors.initials: A
authors.lastname: Galbiati
authors.affiliation: Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, S. Orsola Hospital, 40138, Bologna, Italy.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Montanaro
authors.affiliation: Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, S. Orsola Hospital, 40138, Bologna, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Derenzini
mesh_terms: D000072283:A549 Cells; D045325:HCT116 Cells; D006801:Humans; D061986:MCF-7 Cells; D055550:Protein Stability; D051736:Proto-Oncogene Proteins c-mdm2 / Q000378:metabolism; D012341:RNA, Ribosomal, 5S / Q000235:genetics* / Q000378:metabolism; D012269:Ribosomal Proteins / Q000378:metabolism*; D012270:Ribosomes / Q000378:metabolism*; D035582:Transcription Factor TFIIIA / Q000378:metabolism; D014158:Transcription, Genetic; D016159:Tumor Suppressor Protein p53 / Q000737:chemistry*
chemical_list: D012341:RNA, Ribosomal, 5S; D012269:Ribosomal Proteins; C495901:TP53 protein, human; D035582:Transcription Factor TFIIIA; D016159:Tumor Suppressor Protein p53; C027624:ribosomal protein L11; C549166:ribosomal protein L5, human; C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2
keywords: 5S rRNA; MDM2; p53; ribosomal proteins; ribosome biogenesis inhibition