title: Clinical development of imatinib: an anticancer drug.
abstract: BACKGROUND
  A novel and accurate high-throughput tandem mass spectroscopic method has been developed and validated for determination of imatinib, aprotein-tyrosine kinaseinhibitor against chronic myeloid leukemia.
  
  
  METHODS
  Chromatographic separation was carried on XTerra®RP18 column (150 mm × 4.6 mm, 5 µm particle size) manufactured by Waters Corporation, MA, USA. The detection was performed on a triple quadruple tandem mass spectrometer by multiple reactions monitoring mode via electrospray ionization source.
  
  
  RESULTS
  The selective and sensitive method was linear in the concentration range of 9.57-4513.29 ng/ml and reported no matrix effect.
  
  
  CONCLUSIONS
  The mean Cmaxwas found to be 10-15% lower in European subjects as compared with Indian subjects.
authors.affiliation: Department of Clinical Pharmacology & Pharmacokinetics, Sun Pharmaceutical Industries Ltd, HSIDC, GP-5, Old Delhi Gurgaon Road, Udyog Vihar Industrial Area, Gurgaon 122 015, Haryana, India.
authors.forename: Dipanjan
authors.initials: D
authors.lastname: Goswami
authors.affiliation: Department of Clinical Pharmacology & Pharmacokinetics, Sun Pharmaceutical Industries Ltd, HSIDC, GP-5, Old Delhi Gurgaon Road, Udyog Vihar Industrial Area, Gurgaon 122 015, Haryana, India.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Gurule
authors.affiliation: Department of Clinical Pharmacology & Pharmacokinetics, Sun Pharmaceutical Industries Ltd, HSIDC, GP-5, Old Delhi Gurgaon Road, Udyog Vihar Industrial Area, Gurgaon 122 015, Haryana, India.
authors.forename: Abhiroop
authors.initials: A
authors.lastname: Lahiry
authors.affiliation: Department of Clinical Pharmacology & Pharmacokinetics, Sun Pharmaceutical Industries Ltd, HSIDC, GP-5, Old Delhi Gurgaon Road, Udyog Vihar Industrial Area, Gurgaon 122 015, Haryana, India.
authors.forename: Amit
authors.initials: A
authors.lastname: Anand
authors.affiliation: Department of Clinical Pharmacology & Pharmacokinetics, Sun Pharmaceutical Industries Ltd, HSIDC, GP-5, Old Delhi Gurgaon Road, Udyog Vihar Industrial Area, Gurgaon 122 015, Haryana, India.
authors.forename: Arshad
authors.initials: A
authors.lastname: Khuroo
authors.affiliation: Department of Clinical Pharmacology & Pharmacokinetics, Sun Pharmaceutical Industries Ltd, HSIDC, GP-5, Old Delhi Gurgaon Road, Udyog Vihar Industrial Area, Gurgaon 122 015, Haryana, India.
authors.forename: Tausif
authors.initials: T
authors.lastname: Monif
keywords: bioavailability study; imatinib mesylate; method development; multiple reaction monitoring ISR; validation