title: HLA Alleles are Genetic Markers for Susceptibility and Resistance towards Leprosy in a Mexican Mestizo Population.
abstract: Despite the use of multidrug therapy, leprosy remains endemic in some countries. The association of several human leucocyte antigen (HLA) alleles and gene polymorphisms with leprosy has been demonstrated in many populations, but the major immune contributors associated to the spectrum of leprosy have not been defined yet. In this study, genotyping of HLA-A, -B, -DR, and -DQ alleles was performed in leprosy patients (n = 113) and control subjects (n = 117) from the region with the highest incidence for the disease in México. The odds of developing leprosy and lepromatous subtype were 2.12- and 2.74-fold higher in carriers of HLA-A*28, and 2.48- and 4.14-fold higher for leprosy and dimorphic subtype in carriers of DQB1*06. Interestingly, DQB1*07 was overrepresented in healthy individuals, compared to patients with leprosy (OR = 0.08) and the lepromatous subtype (OR = 0.06). These results suggest that HLA-A*28 is a marker for predisposition to leprosy and the lepromatous subtype and DQB1*06 to leprosy and the dimorphic subtype, while DQB1*07 might be a resistance marker in this Mestizo population.
authors.affiliation: Faculty of Biological and Chemical Sciences, Autonomous University of Sinaloa, Culiacán, Sinaloa, Mexico.
authors.forename: Maribel
authors.initials: M
authors.lastname: Aguilar-Medina
authors.affiliation: Division of Immunogenetics, National Institute of Medical Sciences and Nutrition, CDMX, Mexico.
authors.forename: Monica
authors.initials: M
authors.lastname: Escamilla-Tilch
authors.affiliation: Dermatological Hospital of Sinaloa, Culiacán, Sinaloa, Mexico.
authors.forename: Luis Octavio
authors.initials: LO
authors.lastname: Frías-Castro
authors.affiliation: Faculty of Biological and Chemical Sciences, Autonomous University of Sinaloa, Culiacán, Sinaloa, Mexico.
authors.forename: Geovanni
authors.initials: G
authors.lastname: Romero-Quintana
authors.affiliation: Department of Immunology, National School of Biological Science, National Polytechnic Institute, CDMX, Mexico.
authors.forename: Iris
authors.initials: I
authors.lastname: Estrada-García
authors.affiliation: Department of Immunology, National School of Biological Science, National Polytechnic Institute, CDMX, Mexico.
authors.forename: Sergio
authors.initials: S
authors.lastname: Estrada-Parra
authors.affiliation: Division of Immunogenetics, National Institute of Medical Sciences and Nutrition, CDMX, Mexico.
authors.forename: Julio
authors.initials: J
authors.lastname: Granados
authors.affiliation: Faculty of Biological and Chemical Sciences, Autonomous University of Sinaloa, Culiacán, Sinaloa, Mexico.
authors.forename: Eliakym
authors.initials: E
authors.lastname: Arambula Meraz
authors.affiliation: Division of Infectious Diseases, Boston Children's Hospital and Harvard Medical School, Harvard University, Boston, MA, USA.
authors.forename: Guzman
authors.initials: G
authors.lastname: Sánchez-Schmitz
authors.affiliation: Department of Molecular Microbiology, Washington University, St. Louis, MO, USA.
authors.forename: Shabaana Abdul
authors.initials: SA
authors.lastname: Khader
authors.affiliation: Division of Allergy, Immunology and Rheumatology, University of Rochester Medical Center, School of Medicine and Dentistry, Rochester, NY, USA.
authors.forename: Javier
authors.initials: J
authors.lastname: Rangel-Moreno
authors.affiliation: Faculty of Biological and Chemical Sciences, Autonomous University of Sinaloa, Culiacán, Sinaloa, Mexico.
authors.forename: Rosalío
authors.initials: R
authors.lastname: Ramos-Payán
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D007198:Indians, North American / Q000235:genetics*; D007918:Leprosy / Q000235:genetics*; D008297:Male; D008800:Mexico; D008875:Middle Aged; D011110:Polymorphism, Genetic
chemical_list: D005819:Genetic Markers; D006680:HLA Antigens
keywords: HLA; Leprosy; Mexicans; susceptibility