title: Ultrasmall Biocompatible Bi2Se3Nanodots for Multimodal Imaging-Guided Synergistic Radiophotothermal Therapy against Cancer.
abstract: Sub-3 nm ultrasmall Bi2Se3nanodots stabilized with bovine serum albumin were successfully synthesized through a reaction of hydroxyethylthioselenide with bismuth chloride in aqueous solution under ambient conditions. These nanodots exhibit a high photothermal conversion efficiency (η = 50.7%) due to their strong broad absorbance in the near-infrared (NIR) window and serve as a nanotheranostic agent for photoacoustic imaging and photothermal cancer therapy. In addition, they also display radioenhancement with a ratio of 6% due to their sensitivity to X-rays, which makes them a potential sensitizer for radiotherapy. These nanodots were also labled with radioactive99mTc for quantification of their biodistribution by single-photon-emission computed tomography (SPECT)/computed tomography (CT) imaging. Our work demonstrates the potential of ultrasmall Bi2Se3nanodots in multimodal imaging-guided synergetic radiophotothermal therapy of cancer.
authors.affiliation: Center for Molecular Imaging and Nuclear Medicine, School for Radiological and Interdisciplinary Sciences (RAD-X), Soochow University, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions , Suzhou 215123, P. R. China.|School of Physics and Electronics, Hunan University , Changsha 410082, P. R. China.
authors.forename: Fangxin
authors.initials: F
authors.lastname: Mao
authors.affiliation: Center for Molecular Imaging and Nuclear Medicine, School for Radiological and Interdisciplinary Sciences (RAD-X), Soochow University, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions , Suzhou 215123, P. R. China.
authors.forename: Ling
authors.initials: L
authors.lastname: Wen
authors.affiliation: Center for Molecular Imaging and Nuclear Medicine, School for Radiological and Interdisciplinary Sciences (RAD-X), Soochow University, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions , Suzhou 215123, P. R. China.
authors.forename: Caixia
authors.initials: C
authors.lastname: Sun
authors.affiliation: Center for Molecular Imaging and Nuclear Medicine, School for Radiological and Interdisciplinary Sciences (RAD-X), Soochow University, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions , Suzhou 215123, P. R. China.
authors.forename: Shaohua
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Center for Molecular Imaging and Nuclear Medicine, School for Radiological and Interdisciplinary Sciences (RAD-X), Soochow University, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions , Suzhou 215123, P. R. China.
authors.forename: Guanglin
authors.initials: G
authors.lastname: Wang
authors.affiliation: Center for Molecular Imaging and Nuclear Medicine, School for Radiological and Interdisciplinary Sciences (RAD-X), Soochow University, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions , Suzhou 215123, P. R. China.
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Zeng
authors.affiliation: Center for Molecular Imaging and Nuclear Medicine, School for Radiological and Interdisciplinary Sciences (RAD-X), Soochow University, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions , Suzhou 215123, P. R. China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
authors.affiliation: School of Physics and Electronics, Hunan University , Changsha 410082, P. R. China.
authors.forename: Jianmin
authors.initials: J
authors.lastname: Ma
authors.affiliation: Center for Molecular Imaging and Nuclear Medicine, School for Radiological and Interdisciplinary Sciences (RAD-X), Soochow University, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions , Suzhou 215123, P. R. China.
authors.forename: Mingyuan
authors.initials: M
authors.lastname: Gao
authors.affiliation: Center for Molecular Imaging and Nuclear Medicine, School for Radiological and Interdisciplinary Sciences (RAD-X), Soochow University, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions , Suzhou 215123, P. R. China.
authors.forename: Zhen
authors.identifier: 0000-0003-0333-7699
authors.initials: Z
authors.lastname: Li
mesh_terms: D001729:Bismuth; D064847:Multimodal Imaging; D009369:Neoplasms / Q000628:therapy; D016566:Organoselenium Compounds / Q000493:pharmacokinetics*; D010789:Phototherapy; D018036:Selenium Compounds; D012710:Serum Albumin, Bovine; D000068936:Theranostic Nanomedicine; D014018:Tissue Distribution
chemical_list: D016566:Organoselenium Compounds; D018036:Selenium Compounds; D012710:Serum Albumin, Bovine; C000613026:bismuth selenide; D001729:Bismuth
keywords: bismuth selenide nanodots; bovine serum albumin; multimodal imaging; radiophotothermal therapy; ultrasmall