title: Serotonergic Mechanisms Regulating the GI Tract: Experimental Evidence and Therapeutic Relevance.
abstract: Serotonin (5-hydroxytryptamine; 5-HT) is best known as a neurotransmitter critical for central nervous system (CNS) development and function. 95% of the body's serotonin, however, is produced in the intestine where it has been increasingly recognized for its hormonal, autocrine, paracrine, and endocrine actions. This chapter provides the most current knowledge of the critical autocrine and paracrine roles of 5-HT in intestinal motility and inflammation as well as its function as a hormone in osteocyte homeostasis. Therapeutic applications in each of these areas are also discussed.
authors.affiliation: Division of Pediatric Gastroenterology, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: Natalie
authors.initials: N
authors.lastname: Terry
authors.affiliation: Division of Pediatric Gastroenterology, Department of Pediatrics, Morgan Stanley Children's Hospital, Columbia University Medical Center, New York, NY, USA. kjg2133@cumc.columbia.edu.
authors.forename: Kara Gross
authors.initials: KG
authors.lastname: Margolis
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D016723:Bone Remodeling; D017615:Enteric Nervous System / Q000187:drug effects / Q000378:metabolism* / Q000503:physiopathology; D005765:Gastrointestinal Agents / Q000627:therapeutic use; D005769:Gastrointestinal Motility; D041981:Gastrointestinal Tract / Q000187:drug effects / Q000294:innervation*; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D055495:Neurogenesis; D010011:Osteocytes / Q000378:metabolism; D010024:Osteoporosis / Q000378:metabolism / Q000503:physiopathology; D011985:Receptors, Serotonin / Q000378:metabolism; D059326:Serotonergic Neurons / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism*; D018490:Serotonin Agents / Q000627:therapeutic use; D015398:Signal Transduction
chemical_list: D000893:Anti-Inflammatory Agents; D005765:Gastrointestinal Agents; D011985:Receptors, Serotonin; D018490:Serotonin Agents; D012701:Serotonin
keywords: Bone; Enteric nervous system; Intestinal inflammation; Intestine; Motility; Serotonin