title: Triclosan/triclocarban levels in maternal and umbilical blood samples and their association with fetal malformation.
abstract: Triclosan (TCS) and triclocarban (TCC) are widely used as antimicrobial compounds in consumer products. TCS and TCC are frequently found in waste water and sewage. In this study, we investigate the potential impact of exposure to triclosan (TCS) and triclocarban (TCC) on fetal abnormalities. We measured TCS and TCC levels in maternal and umbilical cord blood samples from 39 pregnant women diagnosed with fetal or post-birth abnormalities at Beijing Obstetrics and Gynecology Hospital. 52 pregnant women who gave birth to healthy neonates during the same period of time were included as controls. Applying ultra-performance liquid chromatography-tandem mass spectrometry, TCS and TCC concentrations were measured in maternal and fetal sera. Significantly increased levels of TCS were detected in maternal sera from mothers with abnormal births. Similar levels of TCS or TCC were found in maternal and cord sera in control group. The concentrations of TCS or TCC in maternal sera correlated with those in umbilical cord sera (r=0.649, P<0.01). These observations suggest that maternal blood test could be a useful assay for detecting fetal exposure to TCS and TCC, and high exposure to TCS may be potentially associated with increased risk for fetal malformations.
authors.affiliation: Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Wei
authors.affiliation: Clinical Center of Reproductive Medicine, Affiliated Hospital of Weifang Medical University, Weifang 261031, China.
authors.forename: Pengyun
authors.initials: P
authors.lastname: Qiao
authors.affiliation: Xiangheyuan Supervision Station, The Institute of Inspection and Supervision, National Health and Family Planning Commission in Chaoyang District of Beijing, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Ruan
authors.affiliation: Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Centre for Disease Control and Prevention, Beijing, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Yin
authors.affiliation: Department of Ultrasound, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China. Electronic address: wuqq2007@163.com.
authors.forename: Qingqing
authors.initials: Q
authors.lastname: Wu
authors.affiliation: Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Centre for Disease Control and Prevention, Beijing, China. Electronic address: shaobingch@sina.com.
authors.forename: Bing
authors.initials: B
authors.lastname: Shao
mesh_terms: D000328:Adult; D002224:Carbanilides / Q000009:adverse effects / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D005333:Fetus / Q000002:abnormalities*; D006801:Humans; D018811:Maternal Exposure / Q000009:adverse effects; D011247:Pregnancy; D049188:Prenatal Injuries / Q000139:chemically induced; D044967:Serum / Q000737:chemistry; D014260:Triclosan / Q000009:adverse effects / Q000097:blood*; D014874:Water Pollutants, Chemical / Q000009:adverse effects*
chemical_list: D002224:Carbanilides; D014874:Water Pollutants, Chemical; D014260:Triclosan; C009540:triclocarban
keywords: Fetal abnormalities; Triclocarban; Triclosan; Umbilical cord blood