title: Effects of blood-flow restriction on biomarkers of myogenesis in response to resistance exercise.
abstract: We investigated the acute myogenic response to resistance exercise with and without blood-flow restriction (BFR). Six men and women (age, 22 ± 1 years) performed unilateral knee extensions at 40% of 1-repetition maximum with or without (CNTRL) BFR applied via pressure cuff inflated to 220 mm Hg. Muscle biopsies were collected at 4 h and 24 h postexercise. Addition of BFR increased myoD and c-Met messenger RNA expression relative to CNTRL. Expression of hepatocyte growth factor protein was significantly higher following CNTRL.
authors.affiliation: a University of Florida, 2004 Mowry Rd. Gainesville, FL 32611, USA.
authors.forename: Andrew S
authors.initials: AS
authors.lastname: Layne
authors.affiliation: b University of Calgary, 2500 University Drive NW. Calgary, AB T2N 1N4, Canada.
authors.forename: Kelly
authors.initials: K
authors.lastname: Larkin-Kaiser
authors.affiliation: c NOVA Southeastern Medical School, 3301 College Ave. Fort Lauderdale, FL 33314, USA.
authors.forename: R Gavin
authors.initials: RG
authors.lastname: MacNeil
authors.affiliation: a University of Florida, 2004 Mowry Rd. Gainesville, FL 32611, USA.
authors.forename: Marvin
authors.initials: M
authors.lastname: Dirain
authors.affiliation: a University of Florida, 2004 Mowry Rd. Gainesville, FL 32611, USA.
authors.forename: Bhanuprasad
authors.initials: B
authors.lastname: Sandesara
authors.affiliation: a University of Florida, 2004 Mowry Rd. Gainesville, FL 32611, USA.
authors.forename: Todd M
authors.initials: TM
authors.lastname: Manini
authors.affiliation: a University of Florida, 2004 Mowry Rd. Gainesville, FL 32611, USA.
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Buford
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D001707:Biopsy, Needle; D003250:Constriction; D018592:Cross-Over Studies; D005260:Female; D005786:Gene Expression Regulation; D017228:Hepatocyte Growth Factor / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008297:Male; D024510:Muscle Development; D017570:MyoD Protein / Q000235:genetics / Q000378:metabolism*; D019859:Proto-Oncogene Proteins c-met / Q000235:genetics / Q000378:metabolism*; D052097:Quadriceps Muscle / Q000254:growth & development / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D055070:Resistance Training / Q000379:methods*; D013997:Time Factors; D015854:Up-Regulation; D055815:Young Adult
chemical_list: D015415:Biomarkers; C066855:HGF protein, human; D017570:MyoD Protein; D012333:RNA, Messenger; D017228:Hepatocyte Growth Factor; C491743:MET protein, human; D019859:Proto-Oncogene Proteins c-met
keywords: KAATSU; blood flow restriction; exercice contre résistance; facteur de croissance des hépatocytes; hepatocyte growth factor; muscle squelettique; myogenesis; myogenèse; resistance exercise; restriction du débit sanguin; skeletal muscle