title: Malondialdehyde as a Prognostic Factor in Alcoholic Hepatitis.
abstract: OBJECTIVE
  Alcoholic hepatitis is a severe complication of alcoholism, associated with high short-term mortality. Although pathogenesis remains obscure, it is generally accepted that lipopolysaccharide-induced cytokine secretion with further generation of reactive oxygen species (ROS) play outstanding roles. Prognosis is uncertain, and the usually employed prognostic scores do not include variables related to ROS generation. Therefore, this study was performed to assess short-term prognostic value of cytokines, nutritional status, different scores [Maddrey, model for end-stage liver disease (MELD), albumin, bilirubin, INR, creatinine index (ABIC), Lille, Glasgow, MELD-Na, Child-Pugh] and malondialdehyde (MDA, as an indicator of lipid peroxidation) at admission and after 1 week, among patients affected by severe acute alcoholic hepatitis (Maddrey index >32).
  
  
  METHODS
  Sixty-two patients affected by severe acute alcoholic hepatitis, for whom we calculated Maddrey, MELD, ABIC, Lille, Glasgow, MELD-Na, Child-Pugh, and determined serum MDA and interleukin (IL)-6, IL-8, IL-4, tumor necrosis factor alpha and interferon gamma levels at admission and after 1 week.
  
  
  RESULTS
  Twenty-four patients died during the follow-up period. MDA showed a better prognostic accuracy than the aforementioned scores, both at admission and after 1 week.
  
  
  CONCLUSIONS
  Our study supports the importance of including MDA assessment in the prognostic evaluation of patients with alcoholic hepatitis.
  
  
  OBJECTIVE
  Alcoholic hepatitis is associated with high short-term mortality. Although not included in prognostic scores, lipid peroxidation plays an outstanding role in its pathogenesis. We found that malondialdehyde levels showed a better prognostic accuracy than the usually employed scores. Therefore, it should be included in the prognostic evaluation of these patients.
authors.affiliation: Servicio de Medicina Interna, Hospital Universitario de Canarias,Universidad de La Laguna, Tenerife, Canary Islands, Spain.
authors.forename: Onán
authors.initials: O
authors.lastname: Pérez-Hernández
authors.affiliation: Servicio de Medicina Interna, Hospital Universitario de Canarias,Universidad de La Laguna, Tenerife, Canary Islands, Spain.
authors.forename: Emilio
authors.initials: E
authors.lastname: González-Reimers
authors.affiliation: Servicio de Medicina Interna, Hospital Universitario de Canarias,Universidad de La Laguna, Tenerife, Canary Islands, Spain.
authors.forename: Geraldine
authors.initials: G
authors.lastname: Quintero-Platt
authors.affiliation: Departamento de Fisiología, Hospital Universitario de Canarias, Universidad de La Laguna, Tenerife, Canary Islands,Spain.
authors.forename: Pedro
authors.initials: P
authors.lastname: Abreu-González
authors.affiliation: Servicio de Laboratorio, Hospital Universitario de Canarias,Universidad de La Laguna, Tenerife, Canary Islands, Spain.
authors.forename: María José de la
authors.initials: MJ
authors.lastname: Vega-Prieto
authors.affiliation: Servicio de Medicina Interna, Hospital Universitario de Canarias,Universidad de La Laguna, Tenerife, Canary Islands, Spain.
authors.forename: María José
authors.initials: MJ
authors.lastname: Sánchez-Pérez
authors.affiliation: Servicio de Medicina Interna, Hospital Universitario de Canarias,Universidad de La Laguna, Tenerife, Canary Islands, Spain.
authors.forename: Candelaria
authors.initials: C
authors.lastname: Martín-González
authors.affiliation: Servicio de Medicina Interna, Hospital Universitario de Canarias,Universidad de La Laguna, Tenerife, Canary Islands, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Martínez-Riera
authors.affiliation: Servicio de Medicina Interna, Hospital Universitario de Canarias,Universidad de La Laguna, Tenerife, Canary Islands, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Santolaria-Fernández
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006519:Hepatitis, Alcoholic / Q000097:blood* / Q000175:diagnosis*; D006760:Hospitalization / Q000639:trends; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D008875:Middle Aged; D011379:Prognosis; D017382:Reactive Oxygen Species / Q000097:blood
chemical_list: D015415:Biomarkers; D017382:Reactive Oxygen Species; D008315:Malondialdehyde