title: Role of Cell Metabolism and Mitochondrial Function During Adult Neurogenesis.
abstract: Brain is the major consumer of glucose in the human body, whose pattern of consumption changes through lifetime, decreasing during adolescence up to adulthood. This evidence leads to the hypothesis that, in cerebral developmental stages, glycolysis might be the driving force for the high-energy requirement. Furthermore, several studies claim that neurogenesis process is accompanied by a shift into mitochondrial oxidative metabolism. Herein, we discuss recent work about cell metabolism during neuronal differentiation process, in particular the mitochondrial role in cellular bioenergy dynamics.
authors.affiliation: CEDOC, NOVA Medical School/Faculdade de Ciência Médicas, Universidade Nova de Lisboa, Campo dos Mártires da Pátria 130, 1169-056, Lisboa, Portugal.|Instituto de Tecnologia Química e Biológica (ITQB), Universidade Nova de Lisboa, Apartado 127, 2781-901, Oeiras, Portugal.|Instituto de Biologia Experimental e Tecnológica (iBET), Apartado 12, 2781-901, Oeiras, Portugal.
authors.forename: Ana S
authors.initials: AS
authors.lastname: Almeida
authors.affiliation: CEDOC, NOVA Medical School/Faculdade de Ciência Médicas, Universidade Nova de Lisboa, Campo dos Mártires da Pátria 130, 1169-056, Lisboa, Portugal. helena.vieira@nms.unl.pt.|Instituto de Biologia Experimental e Tecnológica (iBET), Apartado 12, 2781-901, Oeiras, Portugal. helena.vieira@nms.unl.pt.
authors.forename: Helena L A
authors.initials: HLA
authors.lastname: Vieira
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology* / Q000378:metabolism*; D002470:Cell Survival / Q000502:physiology; D006019:Glycolysis / Q000502:physiology; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D055495:Neurogenesis / Q000502:physiology*; D009474:Neurons / Q000378:metabolism*; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000502:physiology
keywords: Glycolysis; Mitochondria; Neurogenesis; Neuronal differentiation; Oxidative phosphorylation; Oxygen levels