title: Chronic Inflammation: Accelerator of Biological Aging.
abstract: Biological aging is characterized by a chronic low-grade inflammation level. This chronic phenomenon has been named "inflamm-aging" and is a highly significant risk factor for morbidity and mortality in the older persons. The most common theories of inflamm-aging include redox stress, mitochondrial dysfunction, glycation, deregulation of the immune system, hormonal changes, epigenetic modifications, and dysfunction telomere attrition. Inflamm-aging plays a role in the initiation and progression of age-related diseases such as type II diabetes, Alzheimer's disease, cardiovascular disease, frailty, sarcopenia, osteoporosis, and cancer. This review will cover the identification of pathways that control age-related inflammation across multiple systems and its potential causal role in contributing to adverse health outcomes.
authors.affiliation: Gérontopôle, Centre Hospitalier Universitaire de Toulouse, Toulouse, France.|Inserm UMR1027, Université de Toulouse III Paul Sabatier, Toulouse, France.
authors.forename: Bertrand
authors.initials: B
authors.lastname: Fougère
authors.affiliation: Inserm UMR 995, Université de Lille, Lille, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Boulanger
authors.affiliation: Gérontopôle, Centre Hospitalier Universitaire de Toulouse, Toulouse, France.|Inserm UMR1027, Université de Toulouse III Paul Sabatier, Toulouse, France.
authors.forename: Fati
authors.initials: F
authors.lastname: Nourhashémi
authors.affiliation: Gérontopôle, Centre Hospitalier Universitaire de Toulouse, Toulouse, France.|Inserm UMR1027, Université de Toulouse III Paul Sabatier, Toulouse, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Guyonnet
authors.affiliation: Gérontopôle, Centre Hospitalier Universitaire de Toulouse, Toulouse, France.|Inserm UMR1027, Université de Toulouse III Paul Sabatier, Toulouse, France.
authors.forename: Matteo
authors.initials: M
authors.lastname: Cesari
mesh_terms: D000375:Aging / Q000502:physiology*; D015415:Biomarkers; D002908:Chronic Disease; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D009017:Morbidity; D012307:Risk Factors
chemical_list: D015415:Biomarkers
keywords: aging; biology; chronic diseases; inflammation