title: Regional tissue oximetry reflects changes in arterial flow in porcine chronic heart failure treated with venoarterial extracorporeal membrane oxygenation.
abstract: Venoarterial extracorporeal membrane oxygenation (VA ECMO) is widely used in treatment of decompensated heart failure. Our aim was to investigate its effects on regional perfusion and tissue oxygenation with respect to extracorporeal blood flow (EBF). In five swine, decompensated low-output chronic heart failure was induced by long-term rapid ventricular pacing. Subsequently, VA ECMO was introduced and left ventricular (LV) volume, aortic blood pressure, regional arterial flow and tissue oxygenation were continuously recorded at different levels of EBF. With increasing EBF from minimal to 5 l/min, mean arterial pressure increased from 47+/-22 to 84+/-12 mm Hg (P<0.001) and arterial blood flow increased in carotid artery from 211+/-72 to 479+/-58 ml/min (P<0.01) and in subclavian artery from 103+/-49 to 296+/-54 ml/min (P<0.001). Corresponding brain and brachial tissue oxygenation increased promptly from 57+/-6 to 74+/-3 % and from 37+/-6 to 77+/-6 %, respectively (both P<0.01). Presented results confirm that VA ECMO is a capable form of heart support. Regional arterial flow and tissue oxygenation suggest that partial circulatory support may be sufficient to supply brain and peripheral tissue by oxygen.
authors.affiliation: Department of Cardiology, Na Homolce Hospital, Prague, Czech Republic; Department of Physiology, First Faculty of Medicine, Charles University, Prague, Czech Republic. pavel.hala@lf1.cuni.cz.
authors.forename: P
authors.initials: P
authors.lastname: Hála
authors.forename: M
authors.initials: M
authors.lastname: Mlček
authors.forename: P
authors.initials: P
authors.lastname: Ošťádal
authors.forename: D
authors.initials: D
authors.lastname: Janák
authors.forename: M
authors.initials: M
authors.lastname: Popková
authors.forename: T
authors.initials: T
authors.lastname: Bouček
authors.forename: S
authors.initials: S
authors.lastname: Lacko
authors.forename: J
authors.initials: J
authors.lastname: Kudlička
authors.forename: P
authors.initials: P
authors.lastname: Neužil
authors.forename: O
authors.initials: O
authors.lastname: Kittnar
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology*; D002339:Carotid Arteries / Q000378:metabolism; D002908:Chronic Disease; D003331:Coronary Vessels / Q000378:metabolism*; D015199:Extracorporeal Membrane Oxygenation / Q000379:methods*; D005260:Female; D005263:Femoral Artery / Q000378:metabolism; D005268:Femoral Vein / Q000378:metabolism; D006333:Heart Failure / Q000378:metabolism* / Q000628:therapy*; D010092:Oximetry / Q000379:methods*; D013348:Subclavian Artery / Q000378:metabolism; D013552:Swine; D016896:Treatment Outcome