title: Glioblastoma in the elderly: treatment patterns and survival.
abstract: OBJECTIVE
  The optimal treatment for elderly glioblastoma patients is unclear. We conducted a retrospective review of the California Cancer Registry to examine treatment patterns and survival by age.
  
  
  METHODS
  We identified 2670 adult patients from the California Cancer Registry with glioblastoma. We compared the extent of resection, treatment type and modality.
  
  
  RESULTS
  Elderly patients had the greatest overall survival (OS) with combined surgery, radiation and chemotherapy. However, they were more likely to undergo biopsy and less likely to receive combined radiation and chemotherapy than patients <70.
  
  
  CONCLUSIONS
  OS was maximized in elderly patients who were able to get some surgical resection and undergo combined radiation and chemotherapy. OS survival in some elderly patients may be improved by more extensive therapy.
authors.affiliation: Department of Neurosciences, UCSD Moores Cancer Center, University of California San Diego, 3855 Health Science Drive, La Jolla, CA 92093-0819, USA.
authors.forename: Jean-Aine
authors.initials: JA
authors.lastname: Pretanvil
authors.affiliation: Department of Neurosciences, UCSD Moores Cancer Center, University of California San Diego, 3855 Health Science Drive, La Jolla, CA 92093-0819, USA.
authors.forename: Isaac Q
authors.initials: IQ
authors.lastname: Salinas
authors.affiliation: Department of Neurosciences, UCSD Moores Cancer Center, University of California San Diego, 3855 Health Science Drive, La Jolla, CA 92093-0819, USA.
authors.forename: David E
authors.initials: DE
authors.lastname: Piccioni
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D001932:Brain Neoplasms / Q000401:mortality* / Q000628:therapy*; D002140:California / Q000453:epidemiology; D015331:Cohort Studies; D003131:Combined Modality Therapy; D005260:Female; D005909:Glioblastoma / Q000401:mortality* / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012042:Registries / Q000706:statistics & numerical data; D016019:Survival Analysis; D016896:Treatment Outcome; D055815:Young Adult
keywords: California cancer registry; chemotherapy; elderly; glioblastoma; overall survival; radiation; retrospective study; surgery; treatment