title: Clinical research on ultrasonically guided intrahepatic injections of HAS in interventional treatment of liver carcinomas.
abstract: OBJECTIVE
  To study the clinical value of intrahepatic injections of Highly Agglutinative Staphylococcin (HAS) in the interventional treatment of liver carcinomas.
  
  
  METHODS
  Under ultrasonic guidance, intrahepatic injections of HAS were administered in 22 cases of pathologically diagnosed liver carcinomas, 3 days, 7 days, 30 days, 3 months, 6 months, 9 months, and 12 months after microwave coagulation therapy. The dose of each injection was 2000U.
  
  
  RESULTS
  Immunohistochemical staining of the sample from the tumor site after HAS administrations demonstrated a significant increase in the number of antitumor immune cells compared with that before the injections (p<0.01) and an improvement in local immune status. One-year survival rate and recurrence rate, which were determined by Kaplan- Meier method, were 93.8% and 81.9% respectively.
  
  
  CONCLUSIONS
  As a new route of administration, intrahepatic injections of HAS are a safe and effective procedure and deserves further clinical research and discussion.
authors.affiliation: Department of Ultrasound, General Hospital of Chinese PLA , Beijing 100853, PR China.
authors.forename: Peiyuan
authors.initials: P
authors.lastname: Mu
authors.forename: Baowei
authors.initials: B
authors.lastname: Dong
authors.forename: Ping
authors.initials: P
authors.lastname: Liang
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Yu
authors.forename: Li
authors.initials: L
authors.lastname: Su
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D001430:Bacteriocins / Q000008:administration & dosage* / Q000009:adverse effects; D002277:Carcinoma / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000556:secondary; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D018450:Disease Progression; D006801:Humans; D015552:Injections, Intralesional; D053208:Kaplan-Meier Estimate; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary; D009364:Neoplasm Recurrence, Local; D013997:Time Factors; D016896:Treatment Outcome; D018084:Ultrasonography, Interventional
chemical_list: D000970:Antineoplastic Agents; D001430:Bacteriocins; C017724:staphylococcin