title: Lower Level ofBacteroidesin the Gut Microbiota Is Associated with Inflammatory Bowel Disease: A Meta-Analysis.
abstract: Background and Aims.Multiple studies have reported associations between inflammatory bowel disease (IBD) and the flora disequilibrium ofBacteroides. We performed a meta-analysis of the available data to provide a more precise estimate of the association betweenBacteroideslevel in the gut and IBD.Methods.We searched PubMed/MEDLINE, EMBASE, Cochrane Library, Wiley Library, BIOSIS previews, Web of Science, CNKI, and ScienceDirect databases for published literature on IBD and gut microbiota from 1990 to 2016. Quality of all eligible studies was assessed using the Newcastle-Ottawa Quality Assessment Scale (NOS). We compared the level ofBacteroidesin IBD patients with that in a control group without IBD, different types of IBD patients, and IBD patients with active phase and in remission.Results.We identified 63 articles, 9 of which contained sufficient data for evaluation. The mean level ofBacteroideswas significantly lower in Crohn's disease (CD) and ulcerative colitis (UC) patients in active phase than in normal controls. The level ofBacteroidesin remission CD and UC patients was much lower than patients in the control group.Bacteroideslevel was even lower in patients with CD and UC in active phase than in remission.Conclusions.This analysis suggests that lower levels ofBacteroidesare associated with IBD, especially in active phase.
authors.affiliation: Guangdong Province Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Guangzhou, China.
authors.forename: Yingting
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Guangdong Province Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Guangzhou, China.
authors.forename: Fachao
authors.identifier: 0000-0001-8674-4737
authors.initials: F
authors.lastname: Zhi
mesh_terms: D001439:Bacteroides; D003093:Colitis, Ulcerative / Q000382:microbiology* / Q000473:pathology / Q000503:physiopathology*; D003424:Crohn Disease / Q000382:microbiology* / Q000473:pathology / Q000503:physiopathology*; D000069196:Gastrointestinal Microbiome; D006801:Humans