title: Targeting fibroblast growth factor pathways in endometrial cancer.
abstract: Novel treatments that improve outcomes for patients with recurrent or metastatic endometrial cancer (EC) remain an unmet need. Aberrant signaling by fibroblast growth factors (FGFs) and FGF receptors (FGFRs) has been implicated in several human cancers. Activating mutations in FGFR2 have been found in up to 16% of ECs, suggesting an opportunity for targeted therapy. This review summarizes the role of the FGF pathway in angiogenesis and EC, and provides an overview of FGFR-targeted therapies under clinical development for the treatment of EC.
authors.affiliation: Department of Obstetrics and Gynecology, University of Minnesota, Minneapolis, Minnesota.
authors.forename: Boris
authors.initials: B
authors.lastname: Winterhoff
authors.affiliation: Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California. Electronic address: gkonecny@mednet.ucla.edu.
authors.forename: Gottfried E
authors.initials: GE
authors.lastname: Konecny
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D016889:Endometrial Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D005260:Female; D005346:Fibroblast Growth Factors / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods*; D009389:Neovascularization, Pathologic / Q000188:drug therapy / Q000235:genetics; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D005346:Fibroblast Growth Factors
keywords: Angiogenesis; Endometrial cancer; Fibroblast growth factor