title: Clinicopathological features and prognosis of Borrmann type IV gastric cancer.
abstract: OBJECTIVE
  Borrmann type IV gastric cancer is still detected at an advanced stage and survival rates for these patients remain poor. The purpose of this study was to provide valuable prognostic and surgical information on patients with Borrmann type IV gastric cancer.
  
  
  METHODS
  We compared the clinicopathological features of Borrmann type IV gastric cancer with those of other types of gastric cancer. Clinicopathologic features of patients with Borrmann type IV gastric cancer were evaluated as prognostic predictors by univariate and multivariate analyses.
  
  
  RESULTS
  The results showed that Borrmann type IV gastric cancer had more advanced and unfavorable clinicopathological factors compared with other Borrman types. The 5-year overall survival rate was 16.7%, and the median survival 25 months. The 5-year overall survival rate was influenced by tumor size, depth of invasion, lymph node metastasis, and chemotherapy. Of these, independent prognostic factors were lymph node metastasis (present vs absent, risk ratio 1.855, p=0.002) and radical (R0) resection (no vs yes, risk ratio 2.035, p<0.001). A significant survival benefit for radical resection was observed, with a 5-year overall survival rate of 30.7% compared with non-radically resected cases (4.8%).
  
  
  CONCLUSIONS
  Early detection and radical resection were essential to improve the prognosis of patients with Borrmann type IV gastric cancer.
authors.affiliation: Digestive Department, The First Affiliated Hospital of Jiamusi University, Jiamusi City 154003, Heilongjiang Province, China.
authors.forename: Yan-Li
authors.initials: YL
authors.lastname: Zhu
authors.forename: Li
authors.initials: L
authors.lastname: Yang
authors.forename: Zi-Qi
authors.initials: ZQ
authors.lastname: Sui
authors.forename: Liang
authors.initials: L
authors.lastname: Liu
authors.forename: Jing-Feng
authors.initials: JF
authors.lastname: Du
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D016009:Chi-Square Distribution; D005260:Female; D005743:Gastrectomy; D006801:Humans; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000145:classification / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D013997:Time Factors; D016896:Treatment Outcome; D047368:Tumor Burden
chemical_list: D000970:Antineoplastic Agents