title: Lipid Therapy for Intoxications.
abstract: This review discusses the use of intravenous lipid emulsion (ILE) in the treatment of intoxications with lipophilic agents in veterinary medicine. Despite growing scientific evidence that ILE has merit in the treatment of certain poisonings, there is still uncertainty on the optimal composition of the lipid emulsion, the dosing, the mechanism of action, and the efficacy. Therefore, a critical view of the clinician on the applicability of this modality in intoxications is still warranted. The use of ILE therapy is advocated as an antidote in cases of intoxications with some lipophilic substances.
authors.affiliation: Intensive Care Unit, Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, PO Box 80.154, Utrecht NL-3584 CM, The Netherlands. Electronic address: j.h.robben@uu.nl.
authors.forename: Joris Henricus
authors.initials: JH
authors.lastname: Robben
authors.affiliation: Dutch Poisons Information Center, Division of Anesthesiology, Intensive Care and Emergency Medicine, University Medical Center Utrecht, Heidelberglaan 100, P.O. Box 85500, 3508 GA Utrecht, The Netherlands.
authors.forename: Marieke Annet
authors.initials: MA
authors.lastname: Dijkman
mesh_terms: D061605:Administration, Intravenous / Q000379:methods / Q000662:veterinary; D000818:Animals; D002415:Cats; D004285:Dogs; D005217:Fat Emulsions, Intravenous / Q000627:therapeutic use*; D006801:Humans; D007559:Ivermectin / Q000009:adverse effects; D011041:Poisoning / Q000628:therapy / Q000662:veterinary*
chemical_list: D005217:Fat Emulsions, Intravenous; D007559:Ivermectin
keywords: Emulsion; Fat; ILE; Intralipid; Lipid; Lipid resuscitation therapy; Poisoning; Toxin