title: Circadian disruption of ICU patients: A review of pathways, expression, and interventions.
abstract: Intensive care unit patients typically exhibit pathologic wakefulness, poor quality of daytime sleep, nocturnal sleep fragmentation, and sleep patterns that feature the absence of slow wave sleep and rapid eye movement. This article offers a review of the existing literature examining circadian desynchronization in critically ill patients, highlighting contributing factors identified by scholars, and circadian abnormalities observed in these patients. It discusses potential implications for clinical practice and suggests avenues of future research. Elucidating the role of circadian rhythms in the management of critical illness can guide future chronotherapeutic approaches and optimize patient outcomes.
authors.affiliation: National and Kapodistrian University of Athens, School of Health Sciences, ICU Research Unit at "Agioi Anargyroi" General Hospital, Greece.
authors.forename: Anna
authors.initials: A
authors.lastname: Korompeli
authors.affiliation: Central Queensland University, Brisbane, Griffith Institute of Educational Research, Brisbane, Australia.
authors.forename: Olav
authors.initials: O
authors.lastname: Muurlink
authors.affiliation: National and Kapodistrian University of Athens, School of Health Sciences, ICU Research Unit at "Agioi Anargyroi" General Hospital, Greece. Electronic address: nadia.kavrohorianou@gmail.com.
authors.forename: Nadia
authors.initials: N
authors.lastname: Kavrochorianou
authors.affiliation: National and Kapodistrian University of Athens, School of Health Sciences, ICU Research Unit at "Agioi Anargyroi" General Hospital, Greece.
authors.forename: Theodoros
authors.initials: T
authors.lastname: Katsoulas
authors.affiliation: National and Kapodistrian University of Athens, School of Health Sciences, ICU Research Unit at "Agioi Anargyroi" General Hospital, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Fildissis
authors.affiliation: National and Kapodistrian University of Athens, School of Health Sciences, ICU Research Unit at "Agioi Anargyroi" General Hospital, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Baltopoulos
mesh_terms: D021081:Chronobiology Disorders / Q000378:metabolism / Q000503:physiopathology*; D002940:Circadian Rhythm; D056902:Clinical Alarms; D003422:Critical Care; D016638:Critical Illness; D006801:Humans; D007362:Intensive Care Units; D008027:Light / Q000009:adverse effects; D008550:Melatonin / Q000378:metabolism; D009622:Noise / Q000009:adverse effects; D018529:Nutritional Support; D012121:Respiration, Artificial; D012890:Sleep; D012892:Sleep Deprivation; D012895:Sleep, REM
chemical_list: D008550:Melatonin
keywords: Circadian rhythms; Critical illness; Factors; Interventions