title: A focus on resveratrol and ocular problems, especially cataract: From chemistry to medical uses and clinical relevance.
abstract: Low vision and blindness are important health problems that affect millions of people throughout the world. The most common and important pathologies are diabetic retinopathy, age-related macular degeneration, glaucoma as well as cataracts. The latter consists of an opacification of the lens of the eye which impedes the passage of light and represents one of the most important causes of vision loss. Among the risk factors for cataract development, there are life-style factors such as the use of tobacco, abuse of alcohol and unhealthy diet. In light of this, dietary components that possess anti-oxidant activity, such as polyphenols for instance, can be considered good candidates for human studies in the prevention and or treatment of such diseases. Among dietary components, the antioxidant capacity of certain polyphenols is well known, and these could be good candidates. In this review we focus our attention on the current scientific literature regarding to the effects of resveratrol on cataracts and other ocular diseases, along with its potential mechanism/s of action. A large number of preclinical studies support the involvement of resveratrol in clinical trials for the prevention and treatment of eye diseases induced by oxidative stress and inflammation, such as age-related cataract.
authors.affiliation: Department of Zoology, University of Madras, Guindy Campus, Chennai 600025, India.
authors.forename: Ganesh
authors.initials: G
authors.lastname: Goutham
authors.affiliation: Department of Zoology, University of Madras, Guindy Campus, Chennai 600025, India. Electronic address: manikandanramar@yahoo.co.in.
authors.forename: Ramar
authors.initials: R
authors.lastname: Manikandan
authors.affiliation: Department of Biochemistry, Annai Veilakkannis College for Women, Chennai 60015, India.
authors.forename: Manikandan
authors.initials: M
authors.lastname: Beulaja
authors.affiliation: School of Chemical Science and Biotechnology, SASTRA University, Thanjavur, India. Electronic address: thiagi200@yahoo.co.in.
authors.forename: Raman
authors.initials: R
authors.lastname: Thiagarajan
authors.affiliation: Department of Zoology, University of Madras, Guindy Campus, Chennai 600025, India.
authors.forename: Chinnasamy
authors.initials: C
authors.lastname: Arulvasu
authors.affiliation: Department of Zoology, University of Madras, Guindy Campus, Chennai 600025, India.
authors.forename: Munusamy
authors.initials: M
authors.lastname: Arumugam
authors.affiliation: Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA.
authors.forename: William N
authors.initials: WN
authors.lastname: Setzer
authors.affiliation: Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, University of Pavia, Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: Daglia
authors.affiliation: Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
authors.forename: Seyed Fazel
authors.initials: SF
authors.lastname: Nabavi
authors.affiliation: Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. Electronic address: Nabavi208@gmail.com.
authors.forename: Seyed Mohammad
authors.initials: SM
authors.lastname: Nabavi
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D002386:Cataract / Q000178:diet therapy* / Q000188:drug therapy* / Q000378:metabolism; D005901:Glaucoma / Q000178:diet therapy / Q000188:drug therapy / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects / Q000502:physiology; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology; D000077185:Resveratrol; D013267:Stilbenes / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D000975:Antioxidants; D013267:Stilbenes; D000077185:Resveratrol
keywords: Cataracts; Ocular diseases; Phytochemicals; Resveratrol