title: The diagnosis of silent myocardial ischemia. Motion-Frozen (or morphing) myocardial perfusion imaging.
abstract: Silent myocardial ischemia is typically defined as objective evidence of myocardial ischemia in patients without subjective ischemia symptoms. Currently, coronary artery angiography is the gold standard for diagnosis of asymptomatic coronary artery disease (CAD). Computed tomography coronary angiography (CTCA) can visually demonstrate the morphology, trend and extent of coronary stenosis and is commonly used in clinical screening of CAD. Myocardial perfusion imaging can be used not only to identify whether anatomical stenosis causes myocardial dysfunction, but to also assess the risk stratification and prognosis of myocardial disease (MD). Myocardial perfusion imaging using morphing combined with CTCA can simultaneously show the relationship between CAD and myocardial ischemia from an anatomical and functional aspect. This allows earlier diagnosis of asymptomatic CAD myocardial ischemia, accurate identification of the culprit vessels, and could prevent unnecessary interventional therapy. The 1-day dobutamine stress/resting met-hod is also one of the methods used. The combination of CTCA and the morphing technique can provide anatomical and functional information on coronary arteries at the same time, significantly improving the diagnostic sensitivity, specificity, and accuracy of MD.
authors.affiliation: Department of Nuclear Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China. xiewhwh@163.com.
authors.forename: Cheng
authors.initials: C
authors.lastname: Chang
authors.forename: Bo
authors.initials: B
authors.lastname: Ye
authors.forename: Wenhui
authors.initials: W
authors.lastname: Xie
authors.forename: Daoliang
authors.initials: D
authors.lastname: Zhang
authors.forename: Bei
authors.initials: B
authors.lastname: Lei
authors.forename: Xiaodan
authors.initials: X
authors.lastname: Ye
mesh_terms: D016477:Artifacts; D058070:Asymptomatic Diseases; D055424:Cardiac-Gated Imaging Techniques / Q000379:methods*; D000072226:Computed Tomography Angiography / Q000379:methods*; D017023:Coronary Angiography / Q000379:methods*; D006801:Humans; D009038:Motion; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging*; D011856:Radiographic Image Enhancement / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity