title: The impact of blood shear rate on arterial thrombus formation.
abstract: The shear rate and corresponding shear stress have impacts on arterial thrombus formation. In particular, the effects of increasing concentration of platelets at the vessel wall and activation of platelets at this site increase the growth and stability of the thrombi which may result in a fatal narrowing of the arterial lumen. The efficacy of many antithrombotic agents is shear dependent as well. It is apparent that there is a need for a point-of-care device to rapidly monitor the risk for arterial thrombosis and to optimize antithrombotic therapyin vitro.The present review focuses on the essential role of shear rate on arterial thrombus formation in native human blood drawn directly from an antecubital vein.
authors.affiliation: KellSa s.a.s., Str. Campo e Zampo 12, I-13900 Biella, BI, Italy; KellSa s.a.s., Str. Campo e Zampo 12, I-13900 Biella, BI, Italy.
authors.forename: Kjell S
authors.initials: KS
authors.lastname: Sakariassen
authors.affiliation: Alere Technologies AS, POB 6863 Rodelokka, N-0504 Oslo, Norway; Alere Technologies AS, POB 6863 Rodelokka, N-0504 Oslo, Norway.
authors.forename: Lars
authors.initials: L
authors.lastname: Orning
authors.affiliation: Illinois Institute of Technology, 3440 S. Dearborn Street, Chicago, IL 60616, USA; Illinois Institute of Technology, 3440 S. Dearborn Street, Chicago, IL 60616, USA.
authors.forename: Vincent T
authors.initials: VT
authors.lastname: Turitto
keywords: arterial stenosis; platelet activation; platelet adhesion; platelet aggregation; shear rate; shear stress