title: Recent Advances in Transcranial Focused Ultrasound (FUS) Triggered Brain Delivery.
abstract: BACKGROUND
  Successful delivery of therapeutic agents in the brain is very challenging, which makes treatment of various brain disorders very difficult. One of the major causes of this difficulty is the presence of physiological barriers in the brain like blood brain barrier (BBB) and blood cerebrospinal fluid (CSF) barrier. These barriers are very specific and restrict the entry of water soluble agents and ionized molecule.
  
  
  OBJECTIVE
  The current article focuses on the transcranial route, transcranial focused ultrasound (FUS), and the techniques involved in transcranial focused ultrasound (FUS) delivery and recent updates of this system.
  
  
  RESULTS
  The study describes that the FUS in conjunction with various other techniques opens the BBB very effectively.
  
  
  CONCLUSIONS
  The administration of therapeutic agent using various FUS techniques opens a new perspective in treating CNS diseases.
authors.affiliation: Department of Pharmacy, GRD (PG) IMT, Rajpur Road, Dehradun, 248001 Uttarakhand. India.
authors.forename: Nidhi
authors.initials: N
authors.lastname: Nainwal
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000737:chemistry*; D001927:Brain Diseases / Q000188:drug therapy*; D016503:Drug Delivery Systems / Q000379:methods; D006801:Humans; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D000069453:Ultrasonic Waves
chemical_list: D004364:Pharmaceutical Preparations
keywords: Blood brain barrier; drug delivery; focused ultrasound; microbubble; transcranial delivery