title: Vascular Injury Characterizes Doxycycline-induced Upper Gastrointestinal Tract Mucosal Injury.
abstract: Doxycycline is an oral tetracycline antibiotic that has been associated with upper gastrointestinal (GI) mucosal injury. Recently, characteristic vascular degeneration has been reported in the stomach and duodenum in patients with doxycycline-induced injury. Fourteen patients who underwent upper GI endoscopy for nonspecific symptoms and were found to have doxycycline-induced gastric and esophageal injury are described. Most patients showed characteristic vascular injury. A control group of gastric erosions and esophageal ulcers showed no cases with the characteristic vascular changes. Clinical, endoscopic, and pathologic features of doxycycline-induced upper GI tract injury are reviewed, with an emphasis on vascular injury.
authors.affiliation: *James Homer Wright Pathology Laboratories ‡Department of Medicine, Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston †Newton-Wellesley Hospital, Tufts University School of Medicine, Newton, MA.
authors.forename: Angela R
authors.initials: AR
authors.lastname: Shih
authors.forename: Gregory Y
authors.initials: GY
authors.lastname: Lauwers
authors.forename: Anthony
authors.initials: A
authors.lastname: Mattia
authors.forename: Esperance A K
authors.initials: EA
authors.lastname: Schaefer
authors.forename: Joseph
authors.initials: J
authors.lastname: Misdraji
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D016022:Case-Control Studies; D004318:Doxycycline / Q000009:adverse effects*; D004386:Duodenum / Q000098:blood supply / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000473:pathology; D016099:Endoscopy, Gastrointestinal; D005260:Female; D005500:Follow-Up Studies; D005753:Gastric Mucosa / Q000098:blood supply / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000473:pathology; D006801:Humans; D007413:Intestinal Mucosa / Q000098:blood supply / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D014652:Vascular Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D004318:Doxycycline