title: Evaluation of the osteoconductive potential of poly(propylene carbonate)/nano-hydroxyapatite composites mimicking the osteogenic niche for bone augmentation.
abstract: Nano-hydroxyapatite (n-HA) reinforced poly(propylene carbonate) (PPC) composites were prepared for bone repair and reconstruction. The effects of reinforcement on the morphology, mechanical properties and biological performance of n-HA/PPC composites were investigated. The surface morphology and mechanical properties of the composites were characterized by scanning electron microscopy (SEM) and universal material testing machine. The analytical data showed that good incorporation and dispersion of n-HA crystals could be obtained in the PPC matrix at a 30:70 weight ratio. With the increase of n-HA content, the tensile strength increased and the fracture elongation rate decreased. In vitro cell culture revealed that the composite was favorable template for cell attachment and growth. In vivo implantation in femoral condyle defects of rabbits confirmed that the n-HA/PPC composite had good biocompatibility and gradual biodegradability, exhibiting good performance in guided bone regeneration. The results demonstrates that the incorporation of n-HA crystals into PPC matrix provides a practical way to produce biodegradable and cost-competitive composites mimicking the osteogenic niche for bone augmentation.
authors.affiliation: a Research Center for Nano-Biomaterials, Analytical & Testing Center , Sichuan University , Chengdu , China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Zou
authors.affiliation: b School of Materials Science and Engineering , Henan Polytechnic University , Jiaozuo , China.
authors.forename: Jianguo
authors.initials: J
authors.lastname: Liao
authors.affiliation: a Research Center for Nano-Biomaterials, Analytical & Testing Center , Sichuan University , Chengdu , China.
authors.forename: Jidong
authors.initials: J
authors.lastname: Li
authors.affiliation: a Research Center for Nano-Biomaterials, Analytical & Testing Center , Sichuan University , Chengdu , China.
authors.forename: Yubao
authors.initials: Y
authors.lastname: Li
mesh_terms: D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects*; D018786:Bone Substitutes / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D002448:Cell Adhesion / Q000187:drug effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D017886:Durapatite / Q000737:chemistry*; D005269:Femur / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008422:Materials Testing; D053761:Nanocomposites / Q000737:chemistry*; D011407:Propane / Q000031:analogs & derivatives* / Q000737:chemistry; D011817:Rabbits
chemical_list: D018786:Bone Substitutes; C045990:propylene carbonate; D017886:Durapatite; D011407:Propane
keywords: Propylene carbonate; biodegradation; bone regeneration; composite; nano-hydroxyapatite