title: Thrombosis and platelets: an update.
abstract: Haemostasis and thrombosis are complex, multifactorial processes. There is an evolving understanding of the mechanisms influencing vascular occlusion and the role of inflammation and immunity. Despite major advances in elucidating the mechanistic pathways mediating platelet function and thrombosis, challenges in the treatment of vascular occlusive diseases persist. Pharmacological advances have greatly affected thrombotic outcomes, but this has led to the unwanted side effect of bleeding. Detailed assessment of the impact of non-thrombotic diseases on haemostasis and thrombosis is necessary to better evaluate thrombotic risk and establish optimal treatment. This review will focus on recent advances in understanding the contribution of evolving risk factors to thrombosis.
authors.affiliation: University of Massachusetts Medical School, Albert Sherman Center, 368 Plantation St, Worcester, MA 01605, USA.
authors.forename: Milka
authors.initials: M
authors.lastname: Koupenova
authors.affiliation: Westfälische Wilhelms University Muenster, Münster, University Hospital, Department of Anaesthesiology, Intensive Care and Pain Medicine, Experimental and Clinical Haemostasis Research, D-48149 Muenster, Germany Mendelstrasse 11, UK.
authors.forename: Beate E
authors.initials: BE
authors.lastname: Kehrel
authors.affiliation: University of Massachusetts Medical School, Albert Sherman Center, 368 Plantation St, Worcester, MA 01605, USA.
authors.forename: Heather A
authors.initials: HA
authors.lastname: Corkrey
authors.affiliation: University of Massachusetts Medical School, Albert Sherman Center, 368 Plantation St, Worcester, MA 01605, USA.
authors.forename: Jane E
authors.initials: JE
authors.lastname: Freedman
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use; D001792:Blood Platelets / Q000276:immunology / Q000502:physiology*; D042783:Endothelial Cells / Q000502:physiology; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D005544:Forecasting; D006487:Hemostasis / Q000502:physiology; D006801:Humans; D007239:Infections / Q000276:immunology; D063847:Mean Platelet Volume; D012307:Risk Factors; D013927:Thrombosis / Q000209:etiology* / Q000276:immunology / Q000503:physiopathology; D020246:Venous Thrombosis / Q000209:etiology / Q000276:immunology / Q000503:physiopathology
chemical_list: D000925:Anticoagulants; D005343:Fibrinolytic Agents
keywords: Bleeding; Cardiovascular ; Coagulation ; Platelets ; Thrombosis 