title: Minocycline attenuates noise-induced hearing loss in rats.
abstract: Noise-induced hearing loss (NIHL) is a serious health concern and prevention of hair cell death or therapeutic intervention at the early stage of NIHL is critical to preserve hearing. Minocycline is a semi-synthetic derivative of tetracycline and has been shown to have otoprotective effects in ototoxic drug-induced hearing impairment, however, whether minocycline can protect against NIHL has not been investigated. The present study demonstrated elevated ABR (auditory brainstem response) thresholds and outer hair cell loss following traumatic noise exposure, which was mitigated by intraperitoneal administration of minocycline (45mg/kg/d) for 5 consecutive days. In conclusion, the present study demonstrated that minocycline, a clinically approved drug with a good safety profile, can attenuate NIHL in rats and may potentially be used for treatment of hearing loss in clinic.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, 710038, PR China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, 710038, PR China.
authors.forename: Yong-Li
authors.initials: YL
authors.lastname: Song
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, 710038, PR China.
authors.forename: Ke-Yong
authors.initials: KY
authors.lastname: Tian
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, 710038, PR China. Electronic address: qiujh@fmmu.edu.cn.
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Qiu
mesh_terms: D000818:Animals; D001309:Auditory Threshold / Q000187:drug effects*; D004195:Disease Models, Animal; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects* / Q000502:physiology; D018072:Hair Cells, Auditory, Outer / Q000187:drug effects*; D006317:Hearing Loss, Noise-Induced / Q000188:drug therapy*; D008297:Male; D008911:Minocycline / Q000494:pharmacology*; D017207:Rats, Sprague-Dawley
chemical_list: D008911:Minocycline
keywords: Auditory brainstem response; Minocycline; Noise-induced hearing loss