title: Efficacy of desensitizing products containing 8% arginine and calcium carbonate for hypersensitivity relief in MIH-affected molars: an 8-week clinical study.
abstract: OBJECTIVE
  The objective of this study was to compare the efficacy in reducing hypersensitivity in molar incisor hypomineralization (MIH)-affected molars immediately and over 8 weeks combining a single in-office application and a homed-based program with desensitizing products containing 8% arginine and calcium carbonate.
  
  
  METHODS
  Nineteen children with at least one MIH-affected molar with hypersensitivity were included. Hypersensitivity was assessed with an evaporative (air) stimulus and a tactile stimulus. Each child received a single in-office treatment with a desensitizing paste containing 8% arginine and calcium carbonate (elmex Sensitive Professional desensitizing paste), followed by 8 weeks of brushing twice daily with a desensitizing toothpaste containing 8% arginine, calcium carbonate with 1450 ppm fluoride (elmex Sensitive Professional toothpaste), using the elmex Sensitive Professional toothbrush. Additionally, the corresponding mouthwash (elmex Sensitive Professional mouthwash) was used. Clinical assessments were made at baseline, immediately after the in-office treatment and after 1, 2, 4 and 8 weeks of brushing twice daily.
  
  
  RESULTS
  Fifty-six molars with an air blast hypersensitivity score of 2 or 3 (Schiff Cold Air Sensitivity Scale) were included. Application of the desensitizing paste decreased hypersensitivity significantly immediately and throughout the 8 weeks recalls (p < 0.001).
  
  
  CONCLUSIONS
  In conclusion, 8% arginine and calcium carbonate were able to reduce hypersensitivity successfully during this 8-week trial.
  
  
  CONCLUSIONS
  Hypersensitivity is a major complaint in patients with MIH. This is the first study evaluating the desensitizing effect of a desensitizing paste containing 8% arginine and calcium carbonate in patients with MIH.
authors.affiliation: School of Dentistry, Department of Paediatric Dentistry, Medical University Vienna, Sensengasse 2a, 1090, Vienna, Austria. katrin.bekes@meduniwien.ac.at.
authors.forename: Katrin
authors.identifier: http://orcid.org/0000-0002-5249-0123
authors.initials: K
authors.lastname: Bekes
authors.affiliation: Department of Operative Dentistry and Periodontology, Department of Paediatric Dentistry, Martin-Luther-University Halle-Wittenberg, University School of Dental Medicine, Gr. Steinstr. 19, 06108, Halle, Germany.
authors.forename: Karolin
authors.initials: K
authors.lastname: Heinzelmann
authors.affiliation: Karl Donath Laboratory for Hard Tissue and Biomaterial Research, Statistics, Medical University Vienna, Sensengasse 2a, 1090, Vienna, Austria.
authors.forename: Stefan
authors.initials: S
authors.lastname: Lettner
authors.affiliation: Department of Operative Dentistry and Periodontology, Department of Paediatric Dentistry, Martin-Luther-University Halle-Wittenberg, University School of Dental Medicine, Gr. Steinstr. 19, 06108, Halle, Germany.
authors.forename: Hans-Günter
authors.initials: HG
authors.lastname: Schaller
mesh_terms: D000293:Adolescent; D001120:Arginine / Q000627:therapeutic use*; D002119:Calcium Carbonate / Q000627:therapeutic use*; D002648:Child; D057133:Dentin Desensitizing Agents / Q000737:chemistry / Q000627:therapeutic use*; D003807:Dentin Sensitivity / Q000188:drug therapy* / Q000209:etiology*; D005260:Female; D006801:Humans; D007180:Incisor; D008297:Male; D008963:Molar; D017001:Tooth Demineralization / Q000150:complications*; D014100:Toothpastes / Q000737:chemistry / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D057133:Dentin Desensitizing Agents; D014100:Toothpastes; D001120:Arginine; D002119:Calcium Carbonate
keywords: Arginine; Children; Desensitizing; Hypersensitivity; Molar incisor hypomineralization (MIH)