title: Use of finger-piece method for indocyanine green clearance test.
abstract: OBJECTIVE
  The indocyanine green (ICG) finger-piece method (FPM), which allows measurement of the ICG concentration by mounting a light sensor onto a finger, is used to assess liver function. We compared the ICG FPM with the conventional ICG blood sampling method (BSM) in patients with liver disorders.
  
  
  METHODS
  Ninety consecutive patients simultaneously underwent the ICG BSM and ICG FPM. After ICG administration, blood samples were collected at 5, 10, and 15 min for the ICG BSM. The ICG concentration was measured through the finger piece by an ICG clearance meter.
  
  
  RESULTS
  Seventy-one patients (78.9%) had Child-Pugh class A liver disease, and 19 (21.1%) had class B or C. The FPM-measured ICG plasma disappearance rate was positively correlated with the BSM-measured values (r = 0.886, P < 0.001). Bland-Altman analysis showed good agreement between the two methods (mean difference, 0.012 ± 0.018). The FPM-measured ICG plasma disappearance rate was positively correlated with the BSM-measured values both in patients with Child-Pugh class A liver disease (r = 0.821, P < 0.001) and class B or C liver disease (r = 0.859, P < 0.001).
  
  
  CONCLUSIONS
  The ICG FPM may be an alternative to the ICG BSM for liver function assessment.
authors.affiliation: Department of Gastroenterology, Juntendo University Nerima Hospital, Tokyo, Japan.
authors.forename: Eri
authors.initials: E
authors.lastname: Sagawa
authors.affiliation: Department of Gastroenterology, Juntendo University Nerima Hospital, Tokyo, Japan.
authors.forename: Hironao
authors.initials: H
authors.lastname: Okubo
authors.affiliation: Department of Gastroenterology, Juntendo University Nerima Hospital, Tokyo, Japan.
authors.forename: Yushi
authors.initials: Y
authors.lastname: Sorin
authors.affiliation: Department of Gastroenterology, Juntendo University Nerima Hospital, Tokyo, Japan.
authors.forename: Eisuke
authors.initials: E
authors.lastname: Nakadera
authors.affiliation: Department of Gastroenterology, Juntendo University Nerima Hospital, Tokyo, Japan.
authors.forename: Hiroo
authors.initials: H
authors.lastname: Fukada
authors.affiliation: Department of Gastroenterology, Juntendo University Nerima Hospital, Tokyo, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Igusa
authors.affiliation: Institute for liver disease minimal invasive treatment, Shin-Yurigaoka General Hospital, Tokyo, Japan.
authors.forename: Shigehiro
authors.initials: S
authors.lastname: Kokubu
authors.affiliation: Department of Gastroenterology, Juntendo University Nerima Hospital, Tokyo, Japan.
authors.forename: Akihisa
authors.initials: A
authors.lastname: Miyazaki
authors.affiliation: Department of General Surgery, Juntendo University Nerima Hospital, Tokyo, Japan.
authors.forename: Ikuo
authors.initials: I
authors.lastname: Watanobe
authors.affiliation: Department of General Surgery, Juntendo University Nerima Hospital, Tokyo, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Sugo
authors.affiliation: Department of General Surgery, Juntendo University Nerima Hospital, Tokyo, Japan.
authors.forename: Kuniaki
authors.initials: K
authors.lastname: Kojima
authors.affiliation: Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan.
authors.forename: Sumio
authors.initials: S
authors.lastname: Watanabe
keywords: Bland-Altman analysis; clearance meter; liver function