title: Biofilm mitigation by drug (gentamicin)-loaded liposomes promoted by pulsed ultrasound.
abstract: The gentamicin-loaded nano-sized liposomes are shown to penetrate into alginate-based Ralstonia insidiosa bacterial biofilms by acoustic streaming generated by moderate pulsed ultrasound (frequency = 2.25 MHz, 10% duty cycle and spatially and temporally averaged intensity, ISATA≈ 4.4 W/cm2). The liposomes are then burst by the scanned relatively high intensity ultrasound (frequency = 1.1 MHz, 10% duty cycle, the spatially and temporally averaged intensity ISATA≈ 90 W/cm2) in situ, and the gentamicin solution is released from the liposomes resulting in 72% of Ralstonia insidiosa killing.
authors.affiliation: Department of Physics, and Materials Science Program, University of Vermont, Burlington, Vermont 05405, USA dma@uvm.edu, jwu@uvm.edu.
authors.forename: Dong
authors.initials: D
authors.lastname: Ma
authors.affiliation: Department of Physics, and Materials Science Program, University of Vermont, Burlington, Vermont 05405, USA dma@uvm.edu, jwu@uvm.edu.
authors.forename: Junru
authors.initials: J
authors.lastname: Wu
mesh_terms: D018441:Biofilms; D005839:Gentamicins; D008081:Liposomes; D043367:Ralstonia; D000069453:Ultrasonic Waves
chemical_list: D005839:Gentamicins; D008081:Liposomes