title: Use of cidofovir in pediatric patients with adenovirus infection.
abstract: Background: Adenoviruses contribute to morbidity and mortality among immunocompromised pediatric patients including stem cell and solid organ transplant recipients. Cidofovir (CDV), an antiviral compound approved by the FDA in 1996, is used for treatment of adenoviral (ADV) infections in immunocompromised patients despite concern of potential nephrotoxicity.Methods: We conducted a retrospective 5-year review at Boston Children's Hospital of 16 patients (mean age = 6.5 years) receiving 19 courses of CDV. During therapy all pertinent data elements were reviewed to characterize potential response to therapy and incidence of renal dysfunction.Results:Of the 19 CDV courses prescribed, 16 courses (84%) were in patients who had a positive blood ADV Polymerase chain reaction (PCR) alone or in combination with positive ADV PCR/ Direct Immunofluorescence Assay (DFA) at another site. Respiratory symptoms with or without pneumonia were the most common presentation (10/19, 53%). In the majority of blood positive courses (10/16, 63%), viral clearance was also accompanied by clinical response. This was not the case in four courses where patients expired despite viral clearance, including one in which death was directly attributable to adenovirus. There was reversible renal dysfunction observed during the use of CDV.Conclusions:CDV appeared safe and reasonably tolerated for treatment of ADV in this pediatric population and was associated with viral response and clinical improvement in the majority of patients but reversible renal dysfunction was a side effect. Further studies of the efficacy of CDV for immunocompromised children with ADV infection are warranted.
authors.affiliation: Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
authors.forename: Lakshmi
authors.initials: L
authors.lastname: Ganapathi
authors.affiliation: Division of Pharmacy, Boston Children's Hospital, Boston, MA, USA.
authors.forename: Alana
authors.initials: A
authors.lastname: Arnold
authors.affiliation: Division of Pharmacy, Boston Children's Hospital, Boston, MA, USA.
authors.forename: Sarah
authors.initials: S
authors.lastname: Jones
authors.affiliation: Division of Pharmacy, Boston Children's Hospital, Boston, MA, USA.
authors.forename: Al
authors.initials: A
authors.lastname: Patterson
authors.affiliation: Program for Patient Quality and Safety, Boston Children's Hospital, Boston, MA, USA.
authors.forename: Dionne
authors.initials: D
authors.lastname: Graham
authors.affiliation: Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
authors.forename: Marvin
authors.initials: M
authors.lastname: Harper
authors.affiliation: Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
authors.forename: Ofer
authors.initials: O
authors.lastname: Levy
keywords: adenovirus; anti-viral; cidofovir; immunocompromised; pediatric; solid organ; stem-cell