title: Modified Glasgow prognostic score might be a prognostic factor for hepatocellular carcinoma: a meta-analysis.
abstract: BACKGROUND
  Hepatocellular carcinoma (HCC) is the fifth-most common cancer. Recent studies have demonstrated that there was a relationship between modified Glasgow prognostic score (mGPS) and survival of HCC. However, the results were inconsistent.
  
  
  METHODS
  The following databases were searched for relevant articles published until June 2016: PubMed; EMBASE; Web of Science and the China National Knowledge Infrastructure. The strength of association between mGPS and OS of HCC was estimated by pooled HRs with corresponding 95% CIs.
  
  
  RESULTS
  Seven studies with 2047 HCC patients were included in this meta-analysis. The mGPS was an independent marker of poor prognosis in patients with HCC (HR=2.21; 95% CI: 1.73-2.82; I2=51%). In the subgroup analysis of study design, both prospective studies (HR=1.68; 95% CI: 1.35-2.11; I2=0%) and retrospective studies (HR=2.64; 95% CI: 1.92-3.62; I2=39%) with higher mGPS had shorter OS. The patients with resectable HCC and high mGPS also showed shorter OS (HR=2.33; 95% CI: 1.65-3.29; I2=63%). In the subgroup analysis by sample size, both large sample size studies (HR=2.56; 95% CI: 1.50-4.38; I2=72%) and small sample size studies (HR=2.00; 95% CI: 1.62-2.48; I2=0%) showed the same results.
  
  
  CONCLUSIONS
  In conclusion, this meta-analysis suggested that mGPS might be an independent prognostic factor for HCC.
authors.affiliation: Department of General Surgery, Taicang Hospital Affiliated to Soochow University, Taicang, Jiangsu, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Vascular Surgery, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Hu
authors.affiliation: Department of General Surgery, Taicang Hospital Affiliated to Soochow University, Taicang, Jiangsu, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Chang
authors.affiliation: Department of General Surgery, Taicang Hospital Affiliated to Soochow University, Taicang, Jiangsu, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Kang
authors.affiliation: Department of General Surgery, Taicang Hospital Affiliated to Soochow University, Taicang, Jiangsu, China.
authors.forename: Song
authors.initials: S
authors.lastname: Han
authors.affiliation: Department of General Surgery, Taicang Hospital Affiliated to Soochow University, Taicang, Jiangsu, China - luyaoliangdr@126.com.
authors.forename: Yaoliang
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Department of Vascular Surgery, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai, China.
authors.forename: Maoquan
authors.initials: M
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D016009:Chi-Square Distribution; D003661:Decision Support Techniques; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D008113:Liver Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D008875:Middle Aged; D009752:Nutritional Status; D016017:Odds Ratio; D011237:Predictive Value of Tests; D011379:Prognosis; D018570:Risk Assessment; D012307:Risk Factors; D000075462:Serum Albumin, Human / Q000032:analysis; D013997:Time Factors
chemical_list: D014408:Biomarkers, Tumor; D018836:Inflammation Mediators; D002097:C-Reactive Protein; D000075462:Serum Albumin, Human