title: How a Drug Shortage Contributed to a Medication Error Leading to Baclofen Toxicity in an Infant.
abstract: We report the case of a 4-month-old girl who developed encephalopathy, seizures, and respiratory compromise as a result of baclofen toxicity. After some investigation, the accidental ingestion of baclofen was caused by an error in compounding the patient's prescribed omeprazole with baclofen rather than sodium bicarbonate at a retail pharmacy. This error occurred because these two drugs, which were available as powders, were located side by side on the pharmacy shelf. The pharmacist further reported that their normal practice was to use injectable sodium bicarbonate rather than powder to compound an omeprazole suspension; however, the injectable form was not available due to a national shortage. This report demonstrates how a drug shortage contributed to severe clinical consequences and intensive care hospitalization of a patient. It also highlights the need for system improvement to minimize drug shortages.
authors.affiliation: Department of Pediatrics, Floating Hospital for Children at Tufts Medical Center, Boston, Massachusetts ; Department of Pediatric Hematology/Oncology, Johns Hopkins Hospital, Baltimore, Maryland.
authors.forename: Bonnie
authors.initials: B
authors.lastname: Lau
authors.affiliation: Department of Pediatrics, Floating Hospital for Children at Tufts Medical Center, Boston, Massachusetts.
authors.forename: Uma
authors.initials: U
authors.lastname: Khazanie
authors.affiliation: Department of Pediatrics, Floating Hospital for Children at Tufts Medical Center, Boston, Massachusetts.
authors.forename: Emily
authors.initials: E
authors.lastname: Rowe
authors.affiliation: Department of Pediatrics, Floating Hospital for Children at Tufts Medical Center, Boston, Massachusetts.
authors.forename: Karen
authors.initials: K
authors.lastname: Fauman
keywords: adverse drug effect; baclofen; drug shortage; encephalopathy; extemporaneous compounding; medication error; omeprazole; sodium bicarbonate