title: [Cardiovascular risks of non-steroidal anti-inflammatory drugs treatment].
abstract: Non-aspirin non-steroidal anti-inflammatory drugs (NSAIDs) are among the most widely used drugs. Current evidence supports that all NSAIDs increase the risk of heart failure and elevate blood pressure, whereas the risk of thrombotic events varies with the type of drug. Use of newer selective cyclooxygenase-2 inhibitors has been associated with a substantial vascular risk but increasing concern also relates to traditional NSAIDs, in particular diclofenac. This review summarizes the current evidence regarding the cardiovascular safety of NSAIDs and presents recommendations for their use.
authors.affiliation: morten.schmidt@clin.au.dk.
authors.forename: Morten
authors.initials: M
authors.lastname: Schmidt
authors.forename: Emil Loldrup
authors.initials: EL
authors.lastname: Fosbøl
authors.forename: Christian
authors.initials: C
authors.lastname: Torp-Pedersen
authors.forename: Anne-Marie Schjerning
authors.initials: AS
authors.lastname: Olsen
authors.forename: Bo
authors.initials: B
authors.lastname: Christensen
authors.forename: Gunnar H
authors.initials: GH
authors.lastname: Gislason
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001281:Atrial Fibrillation / Q000139:chemically induced; D001794:Blood Pressure / Q000187:drug effects; D002318:Cardiovascular Diseases / Q000139:chemically induced*; D052246:Cyclooxygenase 2 Inhibitors / Q000009:adverse effects; D004008:Diclofenac / Q000009:adverse effects; D011307:Drug Prescriptions / Q000706:statistics & numerical data; D006333:Heart Failure / Q000139:chemically induced; D006801:Humans; D017202:Myocardial Ischemia / Q000139:chemically induced; D012307:Risk Factors; D054556:Venous Thromboembolism / Q000139:chemically induced
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D052246:Cyclooxygenase 2 Inhibitors; D004008:Diclofenac