title: Diffuse shear wave imaging: toward passive elastography using low-frame rate spectral-domain optical coherence tomography.
abstract: Optical coherence tomography (OCT) can map the stiffness of biological tissue by imaging mechanical perturbations (shear waves) propagating in the tissue. Most shear wave elastography (SWE) techniques rely on active shear sources to generate controlled displacements that are tracked at ultrafast imaging rates. Here, we propose a noise-correlation approach to retrieve stiffness information from the imaging of diffuse displacement fields using low-frame rate spectral-domain OCT. We demonstrated the method on tissue-mimicking phantoms and validated the results by comparison with classic ultrafast SWE. Then we investigated the in vivo feasibility on the eye of an anesthetized rat by applying noise correlation to naturally occurring displacements. The results suggest a great potential for passive elastography based on the detection of natural pulsatile motions using conventional spectral-domain OCT systems. This would facilitate the transfer of OCT-elastography to clinical practice, in particular, in ophthalmology or dermatology.
authors.affiliation: Institut Langevin Ondes et Images, ESPCI Paris, Université Paris-Sciences-Lettres, CNRS UMR 7587, Inserm U979-1 rue Jussieu, 75005 Paris, France.
authors.forename: Thu-Mai
authors.initials: TM
authors.lastname: Nguyen
authors.affiliation: Laboratory of Therapeutic Applications of Ultrasound, Inserm U1032-151 cours Albert Thomas, 69003 Lyon, France.
authors.forename: Ali
authors.initials: A
authors.lastname: Zorgani
authors.affiliation: Laboratory of Therapeutic Applications of Ultrasound, Inserm U1032-151 cours Albert Thomas, 69003 Lyon, France.
authors.forename: Maxime
authors.initials: M
authors.lastname: Lescanne
authors.affiliation: Institut Langevin Ondes et Images, ESPCI Paris, Université Paris-Sciences-Lettres, CNRS UMR 7587, Inserm U979-1 rue Jussieu, 75005 Paris, France.
authors.forename: Claude
authors.initials: C
authors.lastname: Boccara
authors.affiliation: Institut Langevin Ondes et Images, ESPCI Paris, Université Paris-Sciences-Lettres, CNRS UMR 7587, Inserm U979-1 rue Jussieu, 75005 Paris, France.
authors.forename: Mathias
authors.initials: M
authors.lastname: Fink
authors.affiliation: Laboratory of Therapeutic Applications of Ultrasound, Inserm U1032-151 cours Albert Thomas, 69003 Lyon, France.
authors.forename: Stefan
authors.initials: S
authors.lastname: Catheline
mesh_terms: D000465:Algorithms; D000818:Animals; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005123:Eye / Q000000981:diagnostic imaging; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D019047:Phantoms, Imaging; D051381:Rats; D041623:Tomography, Optical Coherence / Q000379:methods*