title: The Palisades of Vogt in Congenital Corneal Opacification (An American Ophthalmological Society Thesis).
abstract: OBJECTIVE
  The purposes of this study are first, to determine if the palisades of Vogt (POV) are present or absent in cases of congenital corneal opacification (CCO) by using spectral domain ocular coherence tomography (SD-OCT), and second, in those cases already undergoing penetrating keratoplasty (PKP), to see whether the absence or presence of POV corresponds to re-epithelialization following transplant.
  
  
  METHODS
  This was a retrospective case review of 20 eyes (10 normal, 10 with CCO) evaluated with SD-OCT. The operator was masked to the clinician's assessment of the ocular surface. In those cases where the decision to perform PKP had already been made, the correlation between POV presence or absence and posttransplant graft epithelialization was determined.
  
  
  RESULTS
  All cases were imaged without adverse event. Nine eyes showed some evidence of POV and corresponding vasculature. Eight of 10 affected eyes underwent PKP, and subsequently 7 eyes epithelialized and 2 showed some peripheral neovascularization. The one eye that showed no signs of POV was the one that failed to epithelialize. All control subjects had consistent and regular POV.
  
  
  CONCLUSIONS
  Congenital corneal opacification is rare, and this study shows that at least some POV are present in the majority of cases of CCO. However, the palisades may not be entirely normal compared to age-matched controls. When there was absence of POV in a case of CCO, there was immediate and complete failure of epithelialization.
authors.affiliation: Children's Eye Center, Children's Hospital of Pittsburgh of UPMC (Dr Nischal), the Eye and Ear Institute, UPMC (Dr Nischal, Ms Lathrop), the Department of Ophthalmology, University of Pittsburgh School of Medicine (Dr Nischal, Ms Lathrop), and the Department of Bioengineering, University of Pittsburgh Swanson School of Engineering (Ms Lathrop).
authors.forename: Ken K
authors.initials: KK
authors.lastname: Nischal
authors.affiliation: Children's Eye Center, Children's Hospital of Pittsburgh of UPMC (Dr Nischal), the Eye and Ear Institute, UPMC (Dr Nischal, Ms Lathrop), the Department of Ophthalmology, University of Pittsburgh School of Medicine (Dr Nischal, Ms Lathrop), and the Department of Bioengineering, University of Pittsburgh Swanson School of Engineering (Ms Lathrop).
authors.forename: Kira L
authors.initials: KL
authors.lastname: Lathrop
mesh_terms: D002648:Child; D002675:Child, Preschool; D003315:Cornea / Q000000981:diagnostic imaging* / Q000601:surgery; D003318:Corneal Opacity / Q000151:congenital / Q000175:diagnosis* / Q000601:surgery; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D015948:Keratoplasty, Penetrating / Q000379:methods*; D008297:Male; D009885:Ophthalmology; D012189:Retrospective Studies; D012955:Societies, Medical; D041623:Tomography, Optical Coherence; D014481:United States; D014792:Visual Acuity