title: [Environmental and genetic variables related with alterations in language acquisition in early childhood].
abstract: BACKGROUND
  A great deal of research has addressed problems in the correct acquisition of language, but with few overall conclusions. The reasons for this lie in the individual variability, the existence of different measures for assessing language and the fact that a complex network of genetic and environmental factors are involved in its development.
  
  
  OBJECTIVE
  To review the environmental and genetic variables that have been studied to date, in order to gain a better under-standing of the causes of specific language impairment and create new evidence that can help in the development of screening systems for the early detection of these disorders.
  
  
  METHODS
  The environmental variables related with poorer early child language development include male gender, low level of education of the mother, familial history of problems with language or psychiatric problems, perinatal problems and health problems in early childhood. Bilingualism seems to be a protective factor. Temperament and language are related. Within the genetic factors there are several specific genes associated with language, two of which have a greater influence on its physiological acquisition: FOXP2 and CNTNAP2. The other genes that are most related with specific language disorders are ATP2C2, CMIP, ROBO2, ZNF277 and NOP9.
  
  
  CONCLUSIONS
  The key to comprehending the development of specific language disorders lies in reaching an understanding of the true role played by genes in the ontogenesis, in the regulation of the different developmental processes, and how this role is modulated by the environment.
authors.affiliation: Universidad de Valencia. Facultad de Medicina, 46010 Valencia, Espana.
authors.forename: A
authors.initials: A
authors.lastname: Moriano-Gutierrez
authors.affiliation: Universidad de Valencia. Facultad de Medicina, 46010 Valencia, Espana.
authors.forename: J
authors.initials: J
authors.lastname: Colomer-Revuelta
authors.affiliation: Universidad de Valencia. Facultad de Medicina, 46010 Valencia, Espana.|CIBERSAM, Valencia, Espana.
authors.forename: J
authors.initials: J
authors.lastname: Sanjuan
authors.affiliation: Universidad Politecnica de Valencia, Valencia, Espana.|CIBERSAM, Valencia, Espana.
authors.forename: J M
authors.initials: JM
authors.lastname: Carot-Sierra
mesh_terms: D001720:Birth Injuries / Q000150:complications; D002648:Child; D002657:Child Development; D002675:Child, Preschool; D004410:Dyslexia / Q000209:etiology / Q000235:genetics; D004522:Educational Status; D005260:Female; D059647:Gene-Environment Interaction; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases; D007804:Language Development; D007805:Language Development Disorders / Q000209:etiology* / Q000235:genetics; D008297:Male; D019303:Multilingualism; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000502:physiology; D010031:Otitis / Q000150:complications; D012008:Recurrence; D012307:Risk Factors; D012737:Sex Factors; D012931:Social Environment; D012959:Socioeconomic Factors
chemical_list: D009419:Nerve Tissue Proteins