title: New Iridoid Glucosides from Caryopteris incana (Thunb.) Miq. and Their α-Glucosidase Inhibitory Activities.
abstract: In our continued investigations of the plantCaryopteris incana, five new iridoid glucosides1-5, including twocis-trans-isomers,3and4, along with six known compounds6-11, were isolated from then-butyl alcohol (n-BuOH) soluble fraction of whole dried material ofCaryopteris incana. Their structures were established by a combination of spectroscopic techniques, including 1D and 2D NMR and high resolution electrospray ionization mass spectroscopy (HR-ESI-MS). Furthermore, all isolates were evaluated for their yeast α-glucosidase inhibitory effects. Among these compounds,4-8and10exhibited potent inhibition of α-glucosidase.
authors.affiliation: The MOE Key Laboratory of Standardization of Chinese Medicines, and SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201210, China. maoxd1993@163.com.|Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai 201203, China. maoxd1993@163.com.
authors.forename: Xu-Dong
authors.initials: XD
authors.lastname: Mao
authors.affiliation: The MOE Key Laboratory of Standardization of Chinese Medicines, and SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201210, China. chouguixinzyb@126.com.|Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai 201203, China. chouguixinzyb@126.com.
authors.forename: Gui-Xin
authors.initials: GX
authors.lastname: Chou
authors.affiliation: The MOE Key Laboratory of Standardization of Chinese Medicines, and SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201210, China. zhaoziyang1989@163.com.|Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai 201203, China. zhaoziyang1989@163.com.
authors.forename: Sen-Miao
authors.initials: SM
authors.lastname: Zhao
authors.affiliation: The MOE Key Laboratory of Standardization of Chinese Medicines, and SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201210, China. chenggangzhang88@163.com.|Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai 201203, China. chenggangzhang88@163.com.
authors.forename: Cheng-Gang
authors.initials: CG
authors.lastname: Zhang
mesh_terms: D020001:1-Butanol / Q000737:chemistry; D002236:Carbohydrate Conformation; D065089:Glycoside Hydrolase Inhibitors / Q000737:chemistry* / Q000302:isolation & purification; D006801:Humans; D057888:Iridoid Glucosides / Q000737:chemistry* / Q000302:isolation & purification; D019686:Lamiaceae / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry; D012997:Solvents / Q000737:chemistry; D000520:alpha-Glucosidases / Q000737:chemistry*
chemical_list: D065089:Glycoside Hydrolase Inhibitors; D057888:Iridoid Glucosides; D010936:Plant Extracts; D012997:Solvents; D020001:1-Butanol; D000520:alpha-Glucosidases
keywords: Caryopteris incana; iridoid glucosides; type-II diabetes mellitus; α-glucosidase inhibition