title: A Novel Case of Penile Gangrene in a Patient Treated with Ibrutinib for Chronic Lymphocytic Leukemia.
abstract: Introduction. Ibrutinib is commonly used for the treatment of patients with CLL in either first-line or relapsed/refractory settings.Case Presentation. We present the case of a 74-year-old Caucasian man with CLL who presented with penile gangrene upon initiation of ibrutinib treatment. Our case is the first showing the complication of penile gangrene associated with ibrutinib use. The gangrene was self-limited upon discontinuing ibrutinib.Conclusion. Our finding describes a very rare yet important adverse event associated with ibrutinib use.
authors.affiliation: Department of Internal Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: William Paul
authors.initials: WP
authors.lastname: Skelton
authors.affiliation: Department of Internal Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: Neeka N
authors.initials: NN
authors.lastname: Akhavan
authors.affiliation: Department of Internal Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: Zachary A
authors.initials: ZA
authors.lastname: Taylor
authors.affiliation: Department of Internal Medicine, University of Central Florida, Orlando, FL, USA.
authors.forename: Thu-Cuc
authors.initials: TC
authors.lastname: Nguyen
authors.affiliation: Cancer Specialists of North Florida, Saint Augustine, FL, USA.
authors.forename: Hassan
authors.initials: H
authors.lastname: Hassan
authors.affiliation: Division of Hematology and Oncology, Department of Internal Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: Tabitha N
authors.initials: TN
authors.lastname: Townsend
authors.affiliation: Division of Hematology and Oncology, Department of Internal Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: Prajwol
authors.identifier: 0000-0002-4057-8822
authors.initials: P
authors.lastname: Pathak
authors.affiliation: Division of Hematology and Oncology, Department of Internal Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: Gaurav
authors.initials: G
authors.lastname: Trikha
authors.affiliation: Division of Hematology and Oncology, Department of Internal Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: Nam H
authors.initials: NH
authors.lastname: Dang
authors.affiliation: Division of Hematology and Oncology, Department of Internal Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: Long H
authors.identifier: 0000-0002-6139-6294
authors.initials: LH
authors.lastname: Dang
authors.affiliation: Department of Internal Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: Azka
authors.identifier: 0000-0001-7476-6664
authors.initials: A
authors.lastname: Ali