title: ELMO3 expression indicates a poor prognosis in head and neck squamous cell carcinoma - a short report.
abstract: OBJECTIVE
  Previously, the engulfment and cell motility 3 (ELMO3) protein has been reported to be involved in cell migration and cytoskeletal remodeling. As of yet, nothing is known about the role of ELMO3 in head and neck squamous cell carcinoma (HNSCC). The purpose of this study was to asses ELMO3 expression in postoperatively irradiated HNSCC patients and to evaluate a possible correlation between this expression and patient survival.
  
  
  METHODS
  125 postoperatively irradiated HNSCC patients were included in this study. ELMO3 expression was assessed using immunohistochemistry (IHC). The expression of ELMO3 in the respective HNSCC tumor tissues and its lymph node metastases was correlated with patient survival using Kaplan-Meier curve analyses.
  
  
  RESULTS
  Through IHC, ELMO3 expression was detected in 71.2% of the HNSCC cases tested. We found significantly increased overall and disease-free survival rates and decreased recurrence rates in patients with no detectable ELMO3 expression. In reverse, we found that ELMO3 expression served as an independent marker for a decreased overall and disease-free survival.
  
  
  CONCLUSIONS
  Our data indicate that in the surgically treated and postoperatively irradiated patients tested, ELMO3 expression serves as a predictive marker for reduced survival.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Medical University Vienna, Waehringer Guertel 18-20, A-1090, Vienna, Austria.
authors.forename: Lorenz
authors.initials: L
authors.lastname: Kadletz
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Medical University Vienna, Waehringer Guertel 18-20, A-1090, Vienna, Austria. gregor.heiduschka@meduniwien.ac.at.
authors.forename: Gregor
authors.initials: G
authors.lastname: Heiduschka
authors.affiliation: Department of Pathology, Medical University Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
authors.forename: Robert
authors.initials: R
authors.lastname: Wiebringhaus
authors.affiliation: Department of Pathology, Medical University Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Gurnhofer
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Medical University Vienna, Waehringer Guertel 18-20, A-1090, Vienna, Austria.
authors.forename: Ulana
authors.initials: U
authors.lastname: Kotowski
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Medical University Vienna, Waehringer Guertel 18-20, A-1090, Vienna, Austria.
authors.forename: Georg
authors.initials: G
authors.lastname: Haymerle
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Medical University Vienna, Waehringer Guertel 18-20, A-1090, Vienna, Austria.
authors.forename: Markus
authors.initials: M
authors.lastname: Brunner
authors.affiliation: Department of Oral and Maxillofacial Surgery, National Maxillofacial Unit, St James's Hospital, and Dublin Dental University Hospital, Dublin, Ireland.
authors.forename: Conor
authors.initials: C
authors.lastname: Barry
authors.affiliation: Department of Pathology, Medical University Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.|Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.|Institute of Laboratory Animal Pathology, University of Veterinary Medicine Vienna, Vienna, Austria.
authors.forename: Lukas
authors.initials: L
authors.lastname: Kenner
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D003598:Cytoskeletal Proteins / Q000378:metabolism*; D005260:Female; D006258:Head and Neck Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local / Q000378:metabolism / Q000473:pathology; D011379:Prognosis; D000077195:Squamous Cell Carcinoma of Head and Neck
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D003598:Cytoskeletal Proteins; C486679:ELMO3 protein, human
keywords: ELMO3; Head and neck; Postoperative irradiation; Prognosis; Radiotherapy; Squamous cell carcinoma