title: Dopamine D1-like receptor in lateral habenula nucleus affects contextual fear memory and long-term potentiation in hippocampal CA1 in rats.
abstract: The Lateral Habenula (LHb) plays an important role in emotion and cognition. Recent experiments suggest that LHb has functional interaction with the hippocampus and plays an important role in spatial learning. LHb is reciprocally connected with midbrain monoaminergic brain areas such as the ventral tegmental area (VTA). However, the role of dopamine type 1 receptor (D1R) in LHb in learning and memory is not clear yet. In the present study, D1R agonist or antagonist were administered bilaterally into the LHb in rats. We found that both D1R agonist and antagonist impaired the acquisition of contextual fear memory in rats. D1R agonist or antagonist also impaired long term potentiation (LTP) in hippocampal CA3-CA1 synapses in freely moving rats and attenuated learning induced phosphorylation of α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor (AMPAR) subunit 1 (GluA1) at Ser831 and Ser845 in hippocampus. Taken together, our results suggested that dysfunction of D1R in LHb affected the function of hippocampus.
authors.affiliation: Medical Faculty, Kunming University of Science and Technology, Kunming, Yunnan 650550, China.
authors.forename: Jiangping
authors.initials: J
authors.lastname: Chan
authors.affiliation: Medical Faculty, Kunming University of Science and Technology, Kunming, Yunnan 650550, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Guan
authors.affiliation: Medical Faculty, Kunming University of Science and Technology, Kunming, Yunnan 650550, China.
authors.forename: Yiling
authors.initials: Y
authors.lastname: Ni
authors.affiliation: Medical Faculty, Kunming University of Science and Technology, Kunming, Yunnan 650550, China.
authors.forename: Lilu
authors.initials: L
authors.lastname: Luo
authors.affiliation: Medical Faculty, Kunming University of Science and Technology, Kunming, Yunnan 650550, China.
authors.forename: Liqiang
authors.initials: L
authors.lastname: Yang
authors.affiliation: Medical Faculty, Kunming University of Science and Technology, Kunming, Yunnan 650550, China.
authors.forename: Pengyue
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Medical Faculty, Kunming University of Science and Technology, Kunming, Yunnan 650550, China. Electronic address: zhangjic@126.com.
authors.forename: Jichuan
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Medical Faculty, Kunming University of Science and Technology, Kunming, Yunnan 650550, China. Electronic address: chyanm2@126.com.
authors.forename: Yanmei
authors.initials: Y
authors.lastname: Chen
mesh_terms: D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / Q000494:pharmacology; D000818:Animals; D001552:Benzazepines / Q000494:pharmacology; D056547:CA1 Region, Hippocampal / Q000187:drug effects* / Q000378:metabolism; D002408:Catheters, Indwelling; D015259:Dopamine Agents / Q000494:pharmacology*; D005239:Fear / Q000187:drug effects* / Q000502:physiology; D019262:Habenula / Q000187:drug effects* / Q000378:metabolism; D058542:Implantable Neurostimulators; D007858:Learning / Q000187:drug effects / Q000502:physiology; D017774:Long-Term Potentiation / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008568:Memory / Q000187:drug effects* / Q000502:physiology; D018697:Nootropic Agents / Q000494:pharmacology; D010766:Phosphorylation / Q000187:drug effects; D051381:Rats; D018091:Receptors, AMPA / Q000378:metabolism; D017447:Receptors, Dopamine D1 / Q000378:metabolism; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism
chemical_list: D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; D001552:Benzazepines; D015259:Dopamine Agents; D018697:Nootropic Agents; D018091:Receptors, AMPA; D017447:Receptors, Dopamine D1; C534628:SCH 23390
keywords: AMPA receptor phosphorylation; Dopamine; Fear conditioning; Lateral habenula nucleus; Long term potentiation