title: Angiomatoid fibrous histiocytoma: A case of local recurrence and metastases to loco-regional lymph nodes that responded to chemotherapy.
abstract: Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumour with intermediate malignant potential. We report the case of a patient with local recurrence of AFH in two locations and lymph node metastases 18 months after primary surgical excision. The patient was treated with six cycles of ifosfamide and doxorubicin chemotherapy and a further three courses of ifosfamide monotherapy. Reassessment imaging showed a good response to chemotherapy with reduction in size of the two tumours of local recurrence and the lymph node metastases. This case demonstrates that AFH can respond to chemotherapy, even though it is rarely used.
authors.affiliation: Department of Oncology, Alder Hey Children's Hospital, Liverpool, Merseyside, UK.
authors.forename: Sally
authors.initials: S
authors.lastname: Ogden
authors.affiliation: Department of Oncology, Alder Hey Children's Hospital, Liverpool, Merseyside, UK.
authors.forename: Srikrishna
authors.initials: S
authors.lastname: Harave
authors.affiliation: Department of Oncology, Alder Hey Children's Hospital, Liverpool, Merseyside, UK.
authors.forename: Jo
authors.initials: J
authors.lastname: McPartland
authors.affiliation: Department of Oncology, Royal Manchester Children's Hospital, Manchester, UK.
authors.forename: Bernadette
authors.initials: B
authors.lastname: Brennan
authors.affiliation: Department of Orthopaedics, Royal Orthopaedic Hospital Birmingham, Birmingham, UK.
authors.forename: Lee
authors.initials: L
authors.lastname: Jeys
authors.affiliation: Department of Oncology, Alder Hey Children's Hospital, Liverpool, Merseyside, UK.
authors.forename: Paul
authors.initials: P
authors.lastname: Losty
authors.affiliation: Department of Oncology, Alder Hey Children's Hospital, Liverpool, Merseyside, UK.
authors.forename: Barry
authors.initials: B
authors.lastname: Pizer
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D002675:Child, Preschool; D004317:Doxorubicin / Q000008:administration & dosage; D051677:Histiocytoma, Malignant Fibrous / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D008207:Lymphatic Metastasis; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy* / Q000473:pathology
chemical_list: D004317:Doxorubicin; D007069:Ifosfamide
keywords: angiomatoid; chemotherapy; fibrous; histiocytoma; treatment