title: Anti-angiotensin II type 1 receptor autoantibodies (AT1R-AAs) in patients with systemic sclerosis: lack of association with disease manifestations.
abstract: Angiotensin II type 1 receptor autoantibodies (AT1R-AAs) are known to be associated with malignant hypertension, preeclampsia, and vascular rejection in kidney transplantation. They were also suspected to have pathogenetic role in vasculopathic changes in systemic sclerosis (SSc). Clinical data regarding AT1R-AAs in SSc are scarce. In this work, we will examine the relationship between serum levels of AT1R-AAs and disease manifestations. Serum samples from SSc patients and healthy controls were analyzed for AT1R-AAs by using a commercial ELISA kit. We examined the association of serum levels of AT1R-AA with disease duration, systolic pulmonary artery pressure (sPAP) measurements, and disease manifestations like cutaneous, lung and esophageal involvements, and the presence of digital ulcers in a cross-sectional manner. There was no statistically significant difference in levels of AT1R-AAs between SSc (n = 93) patients and healthy controls (n = 66) (p = 0.23). Serum levels of AT1R-AAs were not correlated with disease duration, sPAP measurements, and showed no association with disease manifestations like lung involvement, esophageal involvement, digital ulcers, and cutaneous fibrosis. In our SSc cohort, AT1R-AA serum levels were not different from healthy subjects and higher levels were not associated with any disease manifestation neither.
authors.affiliation: Department of Internal Medicine, İbn-i Sina Hospital, Ankara University Medical School, 06100, Sıhhiye, Ankara, Turkey. ufukilgen@gmail.com.
authors.forename: Ufuk
authors.identifier: http://orcid.org/0000-0001-6443-6426
authors.initials: U
authors.lastname: İlgen
authors.affiliation: Department of Internal Medicine, İbn-i Sina Hospital, Ankara University Medical School, 06100, Sıhhiye, Ankara, Turkey.
authors.forename: Müçteba Enes
authors.initials: ME
authors.lastname: Yayla
authors.affiliation: Department of Rheumatology, Ankara University Medical School, Ankara, Turkey.
authors.forename: Nurşen
authors.initials: N
authors.lastname: Düzgün
mesh_terms: D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D044140:Receptor, Angiotensin, Type 1 / Q000276:immunology*; D012595:Scleroderma, Systemic / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000276:immunology*; D012720:Severity of Illness Index; D012883:Skin Ulcer / Q000097:blood / Q000209:etiology / Q000276:immunology
chemical_list: D001323:Autoantibodies; D044140:Receptor, Angiotensin, Type 1
keywords: AT1R; Angiotensin II type 1 receptor antibodies; Digital ulceration; Pulmonary arterial hypertension; Systemic sclerosis