title: Risk factors for preeclampsia in infertile Chinese women with polycystic ovary syndrome: A prospective cohort study.
abstract: To explore preconception risk factors for preeclampsia (PE) in women with polycystic ovary syndrome (PCOS), a prospective cohort study was conducted in 92 infertile Chinese women with PCOS who had a singleton pregnancy by ovulation induction and were followed up for 6 weeks after delivery. The patients underwent assessment of physical, endocrine, and metabolic features before ovulation induction. Fifteen (16.3%) patients were diagnosed with PE. Logistic regression analysis showed that preconception sex hormone-binding globulin (SHBG), insulin level at 120 minutes, and body mass index were three independent risk factors for PE (odds ratio [OR], 0.981; 95% confidence interval [CI], 0.964-0.998 [P=.027]; OR, 1.011; 95% CI, 1.000-1.021 [P=.048]; and OR, 1.249; 95% CI, 0.992-1.572 [P=.059], respectively). Receiver operator characteristic analysis indicated the risk value of prepregnancy SHBG, insulin level at 120 minutes, and body mass index (area under the curve=.788, .686, and .697, respectively). Preconception low SHBG levels, overweight/obesity, and hyperinsulinism might be correlated with the subsequent development of PE in patients with PCOS.
authors.affiliation: Department of Reproductive Endocrinology, Obstetrics and Gynecology Hospital, Fudan University and Shanghai Key Laboratory of Female Reproductive Endocrine Related Disease, Shanghai, China.
authors.forename: Hexia
authors.initials: H
authors.lastname: Xia
authors.affiliation: Department of Reproductive Endocrinology, Obstetrics and Gynecology Hospital, Fudan University and Shanghai Key Laboratory of Female Reproductive Endocrine Related Disease, Shanghai, China.
authors.forename: Ruixiu
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Affiliated Hospital of Nantong University, Nantong, Jiangsu, China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Sun
authors.affiliation: Department of Reproductive Endocrinology, Obstetrics and Gynecology Hospital, Fudan University and Shanghai Key Laboratory of Female Reproductive Endocrine Related Disease, Shanghai, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Reproductive Endocrinology, Obstetrics and Gynecology Hospital, Fudan University and Shanghai Key Laboratory of Female Reproductive Endocrine Related Disease, Shanghai, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000328:Adult; D015992:Body Mass Index; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy*; D007328:Insulin / Q000032:analysis; D009765:Obesity / Q000150:complications; D050177:Overweight / Q000150:complications; D010062:Ovulation Induction / Q000379:methods; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000000981:diagnostic imaging / Q000453:epidemiology; D011225:Pre-Eclampsia / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology; D011237:Predictive Value of Tests; D011247:Pregnancy; D011446:Prospective Studies; D012307:Risk Factors; D012738:Sex Hormone-Binding Globulin / Q000032:analysis; D014463:Ultrasonography / Q000379:methods
chemical_list: D007328:Insulin; D012738:Sex Hormone-Binding Globulin
keywords: body mass index; insulin resistance; polycystic ovary syndrome; preeclampsia; sex hormone-binding globulin