title: Flexible Tetrahydropyran Synthesis from Homopropargylic Alcohols Using Sequential Pd-Au Catalysis.
abstract: A flexible synthetic method toward highly substituted tetrahydropyran is reported. The key transformation involves atom-efficient sequential metal catalysis consisting of Pd-catalyzed addition of homopropargylic alcohols to alkoxyallene and the subsequent gold(I)-catalyzed cycloisomerization. Notably, this method gives access to both 2,6-cis- and 2,6-trans-tetrahydropyrans possessing diverse substitution patterns.
authors.affiliation: Department of Chemistry, Pohang University of Science and Technology , Hyoja-dong San 31, Pohang, Kyungbuk 790-784, Republic of Korea.
authors.forename: Jungjoon
authors.initials: J
authors.lastname: Kim
authors.affiliation: Department of Chemistry, Pohang University of Science and Technology , Hyoja-dong San 31, Pohang, Kyungbuk 790-784, Republic of Korea.
authors.forename: Wook
authors.initials: W
authors.lastname: Jeong
authors.affiliation: Department of Chemistry, Pohang University of Science and Technology , Hyoja-dong San 31, Pohang, Kyungbuk 790-784, Republic of Korea.
authors.forename: Young Ho
authors.identifier: 0000-0002-2094-4426
authors.initials: YH
authors.lastname: Rhee