title: Immediate perception of a reward is distinct from the reward's long-term salience.
abstract: Reward perception guides all aspects of animal behavior. However, the relationship between the perceived value of a reward, the latent value of a reward, and the behavioral response remains unclear. Here we report that, given a choice between two sweet and chemically similar sugars-L- and D-arabinose-Drosophila melanogasterprefers D- over L- arabinose, but forms long-term memories of L-arabinose more reliably. Behavioral assays indicate that L-arabinose-generated memories require sugar receptor Gr43a, and calcium imaging and electrophysiological recordings indicate that L- and D-arabinose differentially activate Gr43a-expressing neurons. We posit that the immediate valence of a reward is not always predictive of the long-term reinforcement value of that reward, and that a subset of sugar-sensing neurons may generate distinct representations of similar sugars, allowing for rapid assessment of the salient features of various sugar rewards and generation of reward-specific behaviors. However, how sensory neurons communicate information about L-arabinose quality and concentration-features relevant for long-term memory-remains unknown.
authors.affiliation: Stowers Institute for Medical Research, Kansas City, United States.|Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, United States.
authors.forename: John P
authors.initials: JP
authors.lastname: McGinnis
authors.affiliation: Stowers Institute for Medical Research, Kansas City, United States.
authors.forename: Huoqing
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Evolution, Génomes, Comportement & Ecologie, CNRS, IRD, Université Paris-Sud, Université Paris-Saclay, Paris, France.|AgroParisTech, Paris, France.
authors.forename: Moutaz Ali
authors.initials: MA
authors.lastname: Agha
authors.affiliation: Stowers Institute for Medical Research, Kansas City, United States.
authors.forename: Consuelo Perez
authors.initials: CP
authors.lastname: Sanchez
authors.affiliation: Stowers Institute for Medical Research, Kansas City, United States.
authors.forename: Jeff
authors.initials: J
authors.lastname: Lange
authors.affiliation: Stowers Institute for Medical Research, Kansas City, United States.
authors.forename: Zulin
authors.initials: Z
authors.lastname: Yu
authors.affiliation: Evolution, Génomes, Comportement & Ecologie, CNRS, IRD, Université Paris-Sud, Université Paris-Saclay, Paris, France.|AgroParisTech, Paris, France.
authors.forename: Frederic
authors.initials: F
authors.lastname: Marion-Poll
authors.affiliation: Stowers Institute for Medical Research, Kansas City, United States.|Department of Integrative and Molecular Physiology, University of Kansas School of Medicine, Kansas City, United States.
authors.forename: Kausik
authors.identifier: 0000-0002-9613-6273
authors.initials: K
authors.lastname: Si
mesh_terms: D000818:Animals; D001089:Arabinose / Q000378:metabolism*; D029721:Drosophila Proteins / Q000819:agonists*; D004331:Drosophila melanogaster / Q000502:physiology*; D005247:Feeding Behavior; D010465:Perception; D011956:Receptors, Cell Surface / Q000819:agonists*; D012201:Reward; D011984:Sensory Receptor Cells / Q000187:drug effects / Q000502:physiology
chemical_list: D029721:Drosophila Proteins; C577647:Gr43a protein, Drosophila; D011956:Receptors, Cell Surface; D001089:Arabinose
keywords: D. melanogaster; memory; neuroscience; reward; salience