title: Pregnancy outcomes in oocyte recipients with fibroids not impinging uterine cavity.
abstract: OBJECTIVE
  To examine the effects of fibroid uterus on pregnancy outcomes and endometrial features in ovum donation recipients.
  
  
  METHODS
  Retrospective analysis of 744 ovum donation cycles was conducted in two private IVF centers between 2005 and 2012. All the recipients underwent transvaginal ultrasound examination, including endometrial thickness and grade measurements. Clinical pregnancy, spontaneous miscarriage, and live birth rates were regarded as the primary outcomes.
  
  
  RESULTS
  Leimyomas not distorting the uterine cavity were diagnosed in 264 (35.5%) of the cycles. This group exhibited lower endometrial thickness (8.33 ± 1.8 vs. 8.73 ± 2.03 mm, p = 0.009), lower rates of Grade A (16.1 vs. 30.1%, p < 0.0001), and higher rates of grade C endometrium (10.2 vs. 5.5%, p < 0.0001), compared to the group with sonographically normal uterine cavity. In addition, significantly higher spontaneous miscarriage rates were found in fibroid uteri group (25 vs. 14.5%, p = 0.036).
  
  
  CONCLUSIONS
  Our study results suggest that uterine fibroids not distorting the uterine cavity could constitute a risk factor for spontaneous miscarriage in oocyte donation cycles, possibly via their adverse effect on endometrial receptivity. Further well-designed trials should widely explore this subject, particularly focusing on impact of myomectomy on fertility rates in these patients.
authors.affiliation: Division of Fertility-In Vitro Fertilization, Department of Obstetrics and Gynecology, Faculty of Medicine, Carmel Medical Center, Technion, Michal St., Haifa, Israel. lena2303@gmail.com.
authors.forename: Lena
authors.initials: L
authors.lastname: Sagi-Dain
authors.affiliation: St Georges Hospital, London, UK.|The London Bridge Gynecology Fertility and Genetic Centre, London, UK.
authors.forename: Kamal
authors.initials: K
authors.lastname: Ojha
authors.affiliation: Division of Fertility-In Vitro Fertilization, Faculty of Medicine, Sheba Medical Centre, Tel Aviv, Israel.
authors.forename: David
authors.initials: D
authors.lastname: Bider
authors.affiliation: Division of Fertility-In Vitro Fertilization, Faculty of Medicine, Sheba Medical Centre, Tel Aviv, Israel.
authors.forename: Jacob
authors.initials: J
authors.lastname: Levron
authors.affiliation: In Vitro Fertilization Centre, Isida, Kiev, Ukraine.
authors.forename: Viktor
authors.initials: V
authors.lastname: Zinchenko
authors.affiliation: The London Bridge Gynecology Fertility and Genetic Centre, London, UK.
authors.forename: Sharon
authors.initials: S
authors.lastname: Walster
authors.affiliation: Department of Obstetrics and Gynecology, Bnai Zion Medical Center, Haifa, Israel.
authors.forename: Shlomi
authors.initials: S
authors.lastname: Sagi
authors.affiliation: Division of Fertility-In Vitro Fertilization, Department of Obstetrics and Gynecology, Faculty of Medicine, Carmel Medical Center, Technion, Michal St., Haifa, Israel.
authors.forename: Martha
authors.initials: M
authors.lastname: Dirnfeld
mesh_terms: D000022:Abortion, Spontaneous / Q000209:etiology*; D000328:Adult; D004717:Endometrium / Q000473:pathology; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007889:Leiomyoma / Q000150:complications*; D050498:Live Birth / Q000453:epidemiology*; D018587:Oocyte Donation; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D063186:Uterine Myomectomy; D014594:Uterine Neoplasms / Q000150:complications*
keywords: Endometrial grade; Endometrial thickness; Fibroid uterus; Leiomyomas; Ovum donation