title: [PET-CT Manifestation and Clinical Analysis of Waldenstrom Macroglobulinemia].
abstract: OBJECTIVE
  To investigate the PET-CT manifestation and clinical features of patients with Waldenstrom macroglobulinemia(WM) .
  
  
  METHODS
  The clinical features, laboratorial examination results and PET-CT manifestation of 12 patients with WM were analyzed retrospectively.
  
  
  RESULTS
  The average age of 12 patients with WM was 63.5 years old, the most common incipient symptoms were fatigue and hyperviscosity syndrome. The median SUVmaxof bone marrow was 4.9 (range of 2.1 to 21.9), with diffusely increased18F-FDG uptake in all the patients. In 6 patients, the median SUVmaxof splenomegaly and lymphadenectasis was 3.2 (range of 2.3 to 5.2) and 5.2 (range of 3.6 to 11.2), respectively. The SUVmaxof bone marrow, splenomegaly and lymphadenectasis did not related with white blood cell count, hemoglobin level, blood platelet count, β2- microglobulin level and serum monoclonal IgM of such patients, respectively (both P>0.5). In univariate analysis, serum monoclonal IgM and the SUVmaxof lymphadenectasis were found to be the prognostic factors (both P<0.5).
  
  
  CONCLUSIONS
  The18F-FDG PET-CT feature of Waldenstrom macroglobulinemia has some characteristics which are helpful for setting up the clinical therapeutic schedule.
authors.affiliation: Department of Nuclear Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
authors.forename: Chong-Yang
authors.initials: CY
authors.lastname: Ding
authors.affiliation: Department of Radiology, Zhejiang Taizhou Central Hospital, Taizhou 318000, Zhejiang Province, China.
authors.forename: Hong-Yu
authors.initials: HY
authors.lastname: Liu
authors.affiliation: Department of Nuclear Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Guo
authors.affiliation: Department of Nuclear Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China. E-mail: litiannv@126.com.
authors.forename: Tian-Nu
authors.initials: TN
authors.lastname: Li
mesh_terms: D019788:Fluorodeoxyglucose F18; D006801:Humans; D007075:Immunoglobulin M; D008875:Middle Aged; D010976:Platelet Count; D000072078:Positron Emission Tomography Computed Tomography; D012189:Retrospective Studies; D008258:Waldenstrom Macroglobulinemia
chemical_list: D007075:Immunoglobulin M; D019788:Fluorodeoxyglucose F18