title: Control of adipogenesis by oxylipins, GPCRs and PPARs.
abstract: Oxylipins are bioactive metabolites derived from the oxygenation of ω3 and ω6 polyunsaturated fatty acids, triggered essentially by cyclooxygenase and lipoxygenase activities. Oxylipins are involved in the development and function of adipose tissue and their productions are strictly related to diet quality and quantity. Oxylipins signal via cell surface membrane (G Protein-coupled receptors) and nuclear receptors (peroxisome proliferator-activated receptors), two pathways playing a pivotal role in adipocyte biology. In this review, we made an attempt to cover the available knowledge about synthesis and molecular function of oxylipins known to modulate adipogenesis, adipocyte function and phenotype conversion, with a focus on their interaction with peroxisome proliferator-activated nuclear receptor family.
authors.affiliation: Inserm, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, 31432, France; University of Toulouse, UMR1048, Paul Sabatier University, Toulouse, 31432, France.
authors.forename: Valentin
authors.initials: V
authors.lastname: Barquissau
authors.affiliation: Université Côte d'Azur, CNRS, Inserm, iBV, France.
authors.forename: Rayane A
authors.initials: RA
authors.lastname: Ghandour
authors.affiliation: Université Côte d'Azur, CNRS, Inserm, iBV, France.
authors.forename: Gérard
authors.initials: G
authors.lastname: Ailhaud
authors.affiliation: Technische Universität München, Chair of Molecular Nutritional Medicine, Else Kröner-Fresenius Center, 85350, Freising-Weihenstephan, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Klingenspor
authors.affiliation: Inserm, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, 31432, France; University of Toulouse, UMR1048, Paul Sabatier University, Toulouse, 31432, France; Toulouse University Hospitals, Department of Clinical Biochemistry, Toulouse, 31059, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Langin
authors.affiliation: Université Côte d'Azur, CNRS, Inserm, iBV, France.
authors.forename: Ez-Zoubir
authors.initials: EZ
authors.lastname: Amri
authors.affiliation: Université Côte d'Azur, CNRS, Inserm, iBV, France. Electronic address: pisani@unice.fr.
authors.forename: Didier F
authors.initials: DF
authors.lastname: Pisani
mesh_terms: D050156:Adipogenesis / Q000502:physiology*; D000818:Animals; D006801:Humans; D054883:Oxylipins / Q000378:metabolism*; D047492:Peroxisome Proliferator-Activated Receptors / Q000502:physiology*; D043562:Receptors, G-Protein-Coupled / Q000502:physiology*
chemical_list: D054883:Oxylipins; D047492:Peroxisome Proliferator-Activated Receptors; D043562:Receptors, G-Protein-Coupled
keywords: Adipocyte; Eicosanoid; PPARα; PPARβ/δ; PPARγ; Prostanoid