title: Analysis of Gene Candidate SNP and Ancestral Origin Associated to Obesity and Postoperative Weight Loss in a Cohort of Obese Patients Undergoing RYGB.
abstract: Obesity is the result of a complex interaction between multiple genetic traits and psychological, behavioral, nutritional and environmental factors.
  
  
  
  The aims of the study were (a) to comparatively evaluate the presence of 20 candidate gene single nucleotide polymorphisms (SNPs) in morbidly obese patients, (2) their association to comorbid conditions and (3) their impact on weight loss after a Roux-en-Y gastric bypass (RYGB).
  
  
  
  Two hundred forty-nine patients were eligible for this study. Clinical, anthropometric, biochemical and demographic variables were analyzed. Body mass index (BMI) and composition were assessed by bioelectrical impedance. Twenty SNPs were included for analysis.
  
  
  
  There were 168 Mexican mestizos (67.5 %) and 81 (32.5 %) patients with other ancestral origin. One hundred fifty-nine (64.1 %) were females. Mean ± SD age of the general cohort was 41.1 ± 11.3 years (17-71). Preoperative mean ± SD BMI was 42.5 ± 6.5 kg/m2. There were no significant differences between mestizo and non-mestizo for most SNPs except for IFI, LIPC, and ST8SIA2. FTO (OR = 1.71; CI95 %= 1.14-2.57; p = 0.008) and APOB (OR = 0.31; CI95 %= 0.14-0.72; p = 0.004) result is statistically associated to high blood pressure and FTO (OR = 2.0; CI95 %= 1.3-3.1; p = 0.001), GNB3 (OR = 2.69; CI95 %= 1.0-7.2; p = 0.04), IFI30 (OR = 2.0; CI95 %= 1.16-3.6; p = 0.01), and MC4R (OR = 1.81; CI95 %= 1.13-2.9; p = 0.01) to type 2 diabetes (T2D). Based on ANOVA analysis, POMC (rs1042571) was the SNP most significantly associated to a higher weight loss after RYGB.
  
  
  
  Obese patients have similar SNP frequencies. Several SNP results are statistically associated to high blood pressure and T2D. POMC was significantly associated to a higher surgically induced weight loss.
authors.affiliation: The American British Cowdray (ABC) Medical Center, Center for Nutrition, Obesity and Metabolic Alterations (CNOAM), Mexico City, Mexico.|Departamento de Cirugía, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Av. Vasco de Quiroga No. 15, Tlalpan, Belisario Domínguez Sección XVI, CP 14080, Ciudad de Mexico, Mexico.
authors.forename: David
authors.initials: D
authors.lastname: Velázquez-Fernández
authors.affiliation: National Institute for Genomic Medicine (INMEGEN), Mexico City, Mexico.|Laboratorio de Genómica, División de Estudios de Posgrado e Investigación, Facultad de Odontología UNAM, Mexico City, Mexico.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Mercado-Celis
authors.affiliation: National Institute for Genomic Medicine (INMEGEN), Mexico City, Mexico.|Laboratorio de Genómica, División de Estudios de Posgrado e Investigación, Facultad de Odontología UNAM, Mexico City, Mexico.
authors.forename: Jeny
authors.initials: J
authors.lastname: Flores-Morales
authors.affiliation: The American British Cowdray (ABC) Medical Center, Center for Nutrition, Obesity and Metabolic Alterations (CNOAM), Mexico City, Mexico.
authors.forename: Diana
authors.initials: D
authors.lastname: Clavellina-Gaytán
authors.affiliation: The American British Cowdray (ABC) Medical Center, Center for Nutrition, Obesity and Metabolic Alterations (CNOAM), Mexico City, Mexico.
authors.forename: Ramón
authors.initials: R
authors.lastname: Vidrio
authors.affiliation: The American British Cowdray (ABC) Medical Center, Center for Nutrition, Obesity and Metabolic Alterations (CNOAM), Mexico City, Mexico.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Vidrio
authors.affiliation: The American British Cowdray (ABC) Medical Center, Center for Nutrition, Obesity and Metabolic Alterations (CNOAM), Mexico City, Mexico.
authors.forename: Maureen
authors.initials: M
authors.lastname: Mosti
authors.affiliation: The American British Cowdray (ABC) Medical Center, Center for Nutrition, Obesity and Metabolic Alterations (CNOAM), Mexico City, Mexico.
authors.forename: Hugo
authors.initials: H
authors.lastname: Sánchez-Aguilar
authors.affiliation: The American British Cowdray (ABC) Medical Center, Center for Nutrition, Obesity and Metabolic Alterations (CNOAM), Mexico City, Mexico.
authors.forename: Donaji
authors.initials: D
authors.lastname: Rodriguez
authors.affiliation: Departamento de Cirugía, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Av. Vasco de Quiroga No. 15, Tlalpan, Belisario Domínguez Sección XVI, CP 14080, Ciudad de Mexico, Mexico.
authors.forename: Pablo
authors.initials: P
authors.lastname: León
authors.affiliation: The American British Cowdray (ABC) Medical Center, Center for Nutrition, Obesity and Metabolic Alterations (CNOAM), Mexico City, Mexico. miguelfherrera@gmail.com.|Departamento de Cirugía, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Av. Vasco de Quiroga No. 15, Tlalpan, Belisario Domínguez Sección XVI, CP 14080, Ciudad de Mexico, Mexico. miguelfherrera@gmail.com.
authors.forename: Miguel F
authors.initials: MF
authors.lastname: Herrera
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics; D005260:Female; D015390:Gastric Bypass / Q000379:methods; D020022:Genetic Predisposition to Disease; D006630:Hispanic or Latino; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D009767:Obesity, Morbid / Q000235:genetics* / Q000601:surgery; D020641:Polymorphism, Single Nucleotide; D011184:Postoperative Period; D015431:Weight Loss / Q000235:genetics*; D055815:Young Adult
keywords: Ancestral origin; Gastric bypass; Obesity surgery; Postoperative weight loss; SNP