title: Salvianolate injection in the treatment of unstable angina pectoris: A systematic review and meta-analysis.
abstract: BACKGROUND
  To systematically evaluate the clinical efficacy and safety of Salvianolate injection in the treatment of unstable angina pectoris (UAP).
  
  
  METHODS
  Using literature databases, we conducted a thorough and systematic retrieval of randomized controlled trials (RCTs) that using Salvianolate injection for treating UAP. The Cochrane Risk of Bias Assessment Tool was used to evaluate the methodological quality of the RCTs, and then the data were extracted and meta-analyzed by RevMan5.2 software.
  
  
  RESULTS
  A total of 22 RCTs with 2050 participants were included. The meta-analysis indicated that the combined use of Salvianolate injection and western medicine (WM) in the treatment of UAP can achieve a superior effect in angina pectoris total effective rate (risk ratio [RR] = 1.22, 95% confidence interval [CI] (1.17, 1.27), Z = 10.15, P < 0.00001], and the total effectiveness rate of electrocardiogram [RR = 1.26, 95% CI (1.19,1.34), Z = 7.77, P < 0.00001]. In addition, Salvianolate injection can improve the nitroglycerin withdrawal rate and the serum level of NO, decrease high-sensitivity C-reactive protein. Adverse drug reactions (ADRs) or adverse drug events (ADEs) were reported in 6 RCTs involving 15 cases; however, there were no serious ADRs/ADEs.
  
  
  CONCLUSIONS
  Based on the systematic review, the combined use of Salvianolate injection and WM in the treatment of UAP can achieve a better effect; however, there was no definitive conclusion about its safety. More the large-sample and multicenter RCTs are needed to support its clinical usage.
authors.affiliation: Department of Clinical Pharmacology of Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Zhang
authors.forename: Jiarui
authors.initials: J
authors.lastname: Wu
authors.forename: Shi
authors.initials: S
authors.lastname: Liu
authors.forename: Xiaomeng
authors.initials: X
authors.lastname: Zhang
authors.forename: Bing
authors.initials: B
authors.lastname: Zhang
mesh_terms: D000789:Angina, Unstable / Q000188:drug therapy*; D002316:Cardiotonic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007267:Injections; D008516:Medicine, Chinese Traditional / Q000379:methods; D010936:Plant Extracts / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D002316:Cardiotonic Agents; D010936:Plant Extracts; C561960:salvianolate