title: A multicomponent approach for the preparation of homoallylic alcohols.
abstract: Here we report thein situgeneration of transient allylic boronic species, by reacting TMSCHN2andE-vinyl boronic acids, followed by their subsequent trapping with aldehydes as electrophiles to yield homoallylic alcohols. This metal-free reaction was initially discovered by the use of a flow chemistry approach to generate a variety of homoallylic alcohols in a straightforward fashion and then transferred to a batch protocol.
authors.affiliation: Innovative Technology Centre , Department of Chemistry , University of Cambridge , Lensfield Road , Cambridge CB2 1EW , UK . Email: svl1000@cam.ac.uk ; http://www.leygroup.ch.cam.ac.uk.
authors.forename: Jian-Siang
authors.initials: JS
authors.lastname: Poh
authors.affiliation: Innovative Technology Centre , Department of Chemistry , University of Cambridge , Lensfield Road , Cambridge CB2 1EW , UK . Email: svl1000@cam.ac.uk ; http://www.leygroup.ch.cam.ac.uk.
authors.forename: Shing-Hing
authors.initials: SH
authors.lastname: Lau
authors.affiliation: Innovative Technology Centre , Department of Chemistry , University of Cambridge , Lensfield Road , Cambridge CB2 1EW , UK . Email: svl1000@cam.ac.uk ; http://www.leygroup.ch.cam.ac.uk.
authors.forename: Iain G
authors.initials: IG
authors.lastname: Dykes
authors.affiliation: Innovative Technology Centre , Department of Chemistry , University of Cambridge , Lensfield Road , Cambridge CB2 1EW , UK . Email: svl1000@cam.ac.uk ; http://www.leygroup.ch.cam.ac.uk.
authors.forename: Duc N
authors.initials: DN
authors.lastname: Tran
authors.affiliation: Innovative Technology Centre , Department of Chemistry , University of Cambridge , Lensfield Road , Cambridge CB2 1EW , UK . Email: svl1000@cam.ac.uk ; http://www.leygroup.ch.cam.ac.uk.
authors.forename: Claudio
authors.initials: C
authors.lastname: Battilocchio
authors.affiliation: Innovative Technology Centre , Department of Chemistry , University of Cambridge , Lensfield Road , Cambridge CB2 1EW , UK . Email: svl1000@cam.ac.uk ; http://www.leygroup.ch.cam.ac.uk.
authors.forename: Steven V
authors.initials: SV
authors.lastname: Ley