title: Developmental broadening of inhibitory sensory maps.
abstract: Sensory maps are created by networks of neuronal responses that vary with their anatomical position, such that representations of the external world are systematically and topographically organized in the brain. Current understanding from studying excitatory maps is that maps are sculpted and refined throughout development and/or through sensory experience. Investigating the mouse olfactory bulb, where ongoing neurogenesis continually supplies new inhibitory granule cells into existing circuitry, we isolated the development of sensory maps formed by inhibitory networks. Using in vivo calcium imaging of odor responses, we compared functional responses of both maturing and established granule cells. We found that, in contrast to the refinement observed for excitatory maps, inhibitory sensory maps became broader with maturation. However, like excitatory maps, inhibitory sensory maps are sensitive to experience. These data describe the development of an inhibitory sensory map as a network, highlighting the differences from previously described excitatory maps.
authors.affiliation: Department of Molecular &Human Genetics, Baylor College of Medicine, Houston, Texas, USA.
authors.forename: Kathleen B
authors.initials: KB
authors.lastname: Quast
authors.affiliation: Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, USA.
authors.forename: Kevin
authors.initials: K
authors.lastname: Ung
authors.affiliation: Department of Neuroscience, Baylor College of Medicine, Houston, Texas, USA.
authors.forename: Emmanouil
authors.initials: E
authors.lastname: Froudarakis
authors.affiliation: Department of Neuroscience, Baylor College of Medicine, Houston, Texas, USA.
authors.forename: Longwen
authors.initials: L
authors.lastname: Huang
authors.affiliation: Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, USA.|Medical Scientist Training Program, Baylor College of Medicine, Houston, Texas, USA.
authors.forename: Isabella
authors.initials: I
authors.lastname: Herman
authors.affiliation: SMART Program, Baylor College of Medicine, Houston, Texas, USA.|University of St. Thomas, Houston, Texas, USA.
authors.forename: Angela P
authors.initials: AP
authors.lastname: Addison
authors.affiliation: Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, USA.
authors.forename: Joshua
authors.initials: J
authors.lastname: Ortiz-Guzman
authors.affiliation: Department of Neuroscience, Baylor College of Medicine, Houston, Texas, USA.
authors.forename: Keith
authors.initials: K
authors.lastname: Cordiner
authors.affiliation: Department of Neuroscience, Baylor College of Medicine, Houston, Texas, USA.|Allen Institute for Brain Science, Seattle, Washington, USA.
authors.forename: Peter
authors.initials: P
authors.lastname: Saggau
authors.affiliation: Department of Neuroscience, Baylor College of Medicine, Houston, Texas, USA.|Department of Electrical and Computer Engineering, Rice University, Houston, Texas, USA.
authors.forename: Andreas S
authors.initials: AS
authors.lastname: Tolias
authors.affiliation: Department of Molecular &Human Genetics, Baylor College of Medicine, Houston, Texas, USA.|Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, USA.|Department of Neuroscience, Baylor College of Medicine, Houston, Texas, USA.|Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, Texas, USA.
authors.forename: Benjamin R
authors.initials: BR
authors.lastname: Arenkiel
mesh_terms: D000818:Animals; D005260:Female; D008297:Male; D008822:Mice, Transgenic; D009415:Nerve Net / Q000254:growth & development*; D055495:Neurogenesis / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D009812:Odorants / Q000032:analysis; D009830:Olfactory Bulb / Q000254:growth & development*; D012903:Smell / Q000502:physiology*