title: Transcription Factor Hand-offs "Enhance" Motor Neuron Differentiation.
abstract: Rhee et al. (2016) in this issue of Neuron and Velasco et al. (2016) in Cell Stem Cell find that the activity of transcription factors binding sequentially to a series of transient early and late enhancers directs gene expression that is essential for motor neuron differentiation and function.
authors.affiliation: The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, 725 N. Wolfe Street, PCTB 1004, Baltimore, MD 21205, USA.
authors.forename: Clinton
authors.initials: C
authors.lastname: Cave
authors.affiliation: The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, 725 N. Wolfe Street, PCTB 1004, Baltimore, MD 21205, USA. Electronic address: ssockan1@jhmi.edu.
authors.forename: Shanthini
authors.initials: S
authors.lastname: Sockanathan
mesh_terms: D002454:Cell Differentiation; D015870:Gene Expression; D009046:Motor Neurons / Q000166:cytology; D014157:Transcription Factors / Q000235:genetics*
chemical_list: D014157:Transcription Factors
keywords: differentiation; directed programming; enhancer; motor neuron; temporal occupancy; transcription factor