title: Association between IL18-607C/A and -137G/C polymorphisms and susceptibility to non-small cell lung cancer in a Chinese population.
abstract: Lung cancer is one of the main causes of cancer-related mortality in males and females worldwide. A pleiotropic effect has been observed in the interleukin 18 gene (IL18); its effects include the activation of natural killer cell cytotoxicity and the promotion of the Th1 immune response through the alteration of the expression of interferon-γ and TNF-α in humans. IL18 is therefore involved in the elimination of tumor cells in the human body. We recruited 357 patients with non-small cell lung cancer (NSCLC) and 414 controls to evaluate the correlation between two genetic variations (IL18-607C/A and IL18-137G/C) and the pathogenesis of NSCLC. We used polymerase chain reaction-restriction fragment length polymorphism to genotype IL18-607C/A and IL18-137G/C. Statistical analysis revealed that individuals harboring the AA genotype of IL18-607C/A had an increased risk of NSCLC compared to those harboring the CC genotype (OR = 2.20, 95%CI = 1.30-3.74). Individuals expressing the A allele of IL18-607C/A had an elevated risk of developing NSCLC compared to those expressing the C allele (OR = 1.31, 95%CI = 1.06-1.62). In summary, our analysis shows that the IL18-607C/A genetic variation is related to the risk of NSCLC, whereas the IL18-137G/C variation is not. Therefore, the IL18-607C/A variation is related to the pathogenesis of NSCLC in the Chinese population studied.
authors.affiliation: The Second Breathing and Intensive Care Ward, Zhumadian City Center Hospital, Zhumadian, China wenyungangw@163.com.
authors.forename: W Y
authors.initials: WY
authors.lastname: Gan
authors.affiliation: The Second Breathing and Intensive Care Ward, Zhumadian City Center Hospital, Zhumadian, China.
authors.forename: H M
authors.initials: HM
authors.lastname: Li
authors.affiliation: The Second Breathing and Intensive Care Ward, Zhumadian City Center Hospital, Zhumadian, China.
authors.forename: Y G
authors.initials: YG
authors.lastname: Zhang
authors.affiliation: The Second Breathing and Intensive Care Ward, Zhumadian City Center Hospital, Zhumadian, China.
authors.forename: C M
authors.initials: CM
authors.lastname: Li
authors.affiliation: The Second Breathing and Intensive Care Ward, Zhumadian City Center Hospital, Zhumadian, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics*; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics*; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics; D020382:Interleukin-18 / Q000235:genetics*; D008175:Lung Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
chemical_list: C573415:IFNG protein, human; D020382:Interleukin-18; C439524:TNF protein, human; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma