title: Nanoparticle-aided Radiotherapy for Retinoblastoma and Choroidal Melanoma.
abstract: This work investigates the dosimetric feasibility of employing gold nanoparticles (AuNPs) or carboplatin nano-particles (CNPs) to enhance radiotherapy (RT) treatment efficacy for ocular cancers: retinoblastoma (Rb) and choroidal melanoma (CM), during kV-energy internal and external beam radiotherapy. The results predict that substantial dose enhancement may be achieved by employing AuNPs or CNPs in conjunction with radiotherapy for ocular cancer using kV-energy photon beams. Brachytherapy sources yield higher dose enhancement than the external beam in kV energy range. However, the external beam has the advantage of being non-invasive.
authors.affiliation: University of Massachusetts Lowell, Lowell, MA, USA.
authors.forename: Yucel
authors.initials: Y
authors.lastname: Altundal
authors.affiliation: University of Massachusetts Lowell, Lowell, MA, USA.
authors.forename: Erno
authors.initials: E
authors.lastname: Sajo
authors.affiliation: Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA USA.
authors.forename: G Mike
authors.initials: GM
authors.lastname: Makrigiorgos
authors.affiliation: Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA USA.
authors.forename: Ross I
authors.initials: RI
authors.lastname: Berbeco
authors.affiliation: University of Massachusetts Lowell, Lowell, MA, USA; Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA USA.
authors.forename: Wilfred
authors.initials: W
authors.lastname: Ngwa
keywords: Choroidal Meanoma; Dose Enhancement; Nanoparticles; Retinoblastoma