title: Spectrum of Childhood and Adolescent Ovarian Tumors in India: 25 Years Experience at a Single Institution.
abstract: BACKGROUND
  Ovarian tumour in children and adolescent girls form an uncommon but important part of gynaecological malignancies. They account for 1% of all the childhood malignancies and 8% of all abdominal tumours in children. Since the ovarian cysts are thought to arise from mature follicles, these tumours were considered to be infrequent in the paediatric population.
  
  
  OBJECTIVE
  The rarity of this condition prompted us to conduct this study and share our experience on the incidence and clinicopathological features of different ovarian tumours in girls up to 20 years of age observed in last 25 years at a single tertiary care hospital.
  
  
  METHODS
  This was a retrospective study conducted in the Department of Pathology at a tertiary hospital, Delhi. All ovarian tumours up to the age of 20 years in the past 25 years (1990-2014) were included for the purpose of studying the clinicopathological aspects of ovarian tumours in this age group. Descriptive statistics for prevalence and age-wise prevalence was done. Chi-square test, to find an association between the age, laterality and size with malignancy was performed.
  
  
  RESULTS
  We received a total of 1102 cases of ovarian tumours over the period of 25 years (1990 to 2014), of which 112 (10%) cases were seen in girls up to 20 years of age. The mean age of the patients was 15.3 ± 4 years. The most common presenting complaint was pain abdomen (46.4 %) There was a statistically significant correlation found between size and malignancy status of tumours in our study (p = 0.00). Of 112 cases of ovarian tumours, 39/112 (34.8%) were malignant and 73/112 (65.2%) were benign. Mature cystic teratoma (27.6%) was the most common type of benign tumour in this age group and immature teratomas were the most common type of malignant ovarian neoplasms.
  
  
  CONCLUSIONS
  Premenarchal girls with ovarian masses may have varied presentations. Abdominal pain is the most common presenting complaint of young adolescent girls with adnexal masses. So the index of suspicion should be kept high and prompt investigations like ultrasound must be performed early to rule out such adnexal masses. Immature Teratoma was the most common malignant and mature cystic teratoma was the most common benign tumour in our study.
authors.affiliation: Department of Pathology, NDMC Medical College and Hindu Rao Hospital, Guru Gobind Singh Indraprastha University, New Delhi, India.
authors.forename: Ruchi
authors.initials: R
authors.lastname: Rathore
authors.affiliation: Department of Pathology, University College of Medical Sciences, Delhi University, New Delhi, India.
authors.forename: Sonal
authors.initials: S
authors.lastname: Sharma
authors.affiliation: Department of Pathology, University College of Medical Sciences, Delhi University, New Delhi, India.
authors.forename: Deepshikha
authors.initials: D
authors.lastname: Arora
keywords: immature teratoma; incidence; malignancy; ovary; paediatric population