title: 10 kHz High-Frequency Spinal Cord Stimulation for Chronic Axial Low Back Pain in Patients With No History of Spinal Surgery: A Preliminary, Prospective, Open Label and Proof-of-Concept Study.
abstract: OBJECTIVE
  To explore the effectiveness of 10 kHz high frequency spinal cord stimulation (HF10 therapy) treatment of chronic low back pain in patients who have not had spinal surgery.
  
  
  METHODS
  Patients with chronic low back pain without prior spinal surgery were evaluated by a team of spine surgeons to rule out any spinal pathology amenable to surgical interventions and by a multidisciplinary pain team to confirm eligibility for the study. After a successful (>50% back pain reduction) trial of HF10 therapy, enrolled subjects underwent permanent system implantation and were followed-up one year post-implant.
  
  
  RESULTS
  About 95% of the enrolled subjects (20/21) received the permanent system. At 12 months post-implant, both back pain VAS score and ODI were significantly reduced compared with baseline values (by 73% and 48%, respectively); an estimated quality-adjusted life year gain of 0.47 and a reduction in opioid use by 64% was observed. Four more patients among those unable to work at baseline due to back pain were employed at 12 months post-implant. There were no serious adverse events.
  
  
  CONCLUSIONS
  HF10 therapy may provide significant back pain relief, reduction in disability, improvement quality of life, and reduction in opioid use in chronic low back pain not resulting from spinal surgery.
authors.affiliation: Guys and St Thomas' NHS Trust, Consultant in Pain Medicine, London, UK.
authors.forename: Adnan
authors.initials: A
authors.lastname: Al-Kaisy
authors.affiliation: Guys and St Thomas' NHS Trust, Consultant in Pain Medicine, London, UK.
authors.forename: Stefano
authors.initials: S
authors.lastname: Palmisani
authors.affiliation: Guys and St Thomas' NHS Trust, Consultant in Pain Medicine, London, UK.
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Smith
authors.affiliation: Guys and St Thomas' NHS Trust, Consultant in Pain Medicine, London, UK.
authors.forename: David
authors.initials: D
authors.lastname: Pang
authors.affiliation: Consultant Orthopaedic and Spinal Surgeon, Guys and St Thomas' NHS Trust, London, UK.
authors.forename: Khai
authors.initials: K
authors.lastname: Lam
authors.affiliation: Consultant Orthopaedic and Spinal Surgeon, Epsom and St Helier University Hospitals NHS Trust, Sutton, UK.
authors.forename: William
authors.initials: W
authors.lastname: Burgoyne
authors.affiliation: Guys and St Thomas' NHS Trust, Consultant Radiologist, London, UK.
authors.forename: Russell
authors.initials: R
authors.lastname: Houghton
authors.affiliation: Guys and St Thomas' NHS Trust, Research Manager, London, UK.
authors.forename: Emma
authors.initials: E
authors.lastname: Hudson
authors.affiliation: Consultant Orthopaedic and Spinal Surgeon, Guys and St Thomas' NHS Trust, London, UK.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Lucas
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001368:Axis, Cervical Vertebra / Q000000981:diagnostic imaging / Q000473:pathology; D059350:Chronic Pain / Q000628:therapy; D004651:Employment; D005260:Female; D006801:Humans; D017116:Low Back Pain / Q000523:psychology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D011446:Prospective Studies; D012890:Sleep / Q000502:physiology; D062187:Spinal Cord Stimulation / Q000379:methods*; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D055815:Young Adult
keywords: 10 kHz; chronic back pain; high frequency stimulation; spinal cord stimulation