title: HEDD: the human epigenetic drug database.
abstract: Epigenetic drugs are chemical compounds that target disordered post-translational modification of histone proteins and DNA through enzymes, and the recognition of these changes by adaptor proteins. Epigenetic drug-related experimental data such as gene expression probed by high-throughput sequencing, co-crystal structure probed by X-RAY diffraction and binding constants probed by bio-assay have become widely available. The mining and integration of multiple kinds of data can be beneficial to drug discovery and drug repurposing. HEMD and other epigenetic databases store comprehensively epigenetic data where users can acquire segmental information of epigenetic drugs. However, some data types such as high-throughput datasets are not provide by these databases and they do not support flexible queries for epigenetic drug-related experimental data. Therefore, in reference to HEMD and other epigenetic databases, we developed a relatively comprehensive database for human epigenetic drugs. The human epigenetic drug database (HEDD) focuses on the storage and integration of epigenetic drug datasets obtained from laboratory experiments and manually curated information. The latest release of HEDD incorporates five kinds of datasets: (i) drug, (ii) target, (iii) disease, (vi) high-throughput and (v) complex. In order to facilitate data extraction, flexible search options were built in HEDD, which allowed an unlimited condition query for specific kinds of datasets using drug names, diseases and experiment types.Database URL: http://hedds.org/.
authors.affiliation: Department of Bioscience, School of Life Science, Jilin Normal University, Siping, China qiyunfeng911@outlook.com.
authors.forename: Yunfeng
authors.initials: Y
authors.lastname: Qi
authors.affiliation: Department of Computer Science and Technology, Computer College, Jilin Normal University, Siping, China.
authors.forename: Dadong
authors.initials: D
authors.lastname: Wang
authors.affiliation: Department of Social Physical Education, Physical Education College, Jilin Normal University, Siping, China.
authors.forename: Daying
authors.initials: D
authors.lastname: Wang
authors.affiliation: Department of Biotechnology, School of Life Science, Jilin Normal University, Siping, China.
authors.forename: Taicheng
authors.initials: T
authors.lastname: Jin
authors.affiliation: Department of Bioscience, School of Life Science, Jilin Normal University, Siping, China.
authors.forename: Liping
authors.initials: L
authors.lastname: Yang
authors.affiliation: Department of Bioscience, School of Life Science, Jilin Normal University, Siping, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Wu
authors.affiliation: Department of Bioscience, School of Life Science, Jilin Normal University, Siping, China.
authors.forename: Yaoyao
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Bioscience, School of Life Science, Jilin Normal University, Siping, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Bioscience, School of Life Science, Jilin Normal University, Siping, China.
authors.forename: Fengping
authors.initials: F
authors.lastname: Du
authors.affiliation: Department of Bioscience, School of Life Science, Jilin Normal University, Siping, China.
authors.forename: Mingxia
authors.initials: M
authors.lastname: Song
authors.affiliation: Department of Biotechnology, School of Life Science, Jilin Normal University, Siping, China.
authors.forename: Renjun
authors.initials: R
authors.lastname: Wang
mesh_terms: D030541:Databases, Genetic; D044127:Epigenesis, Genetic; D006801:Humans; D010597:Pharmacogenetics / Q000379:methods*