title: Lesser Toxicities of Belotecan in Patients with Small Cell Lung Cancer: A Retrospective Single-Center Study of Camptothecin Analogs.
abstract: Purpose. Topotecan and belotecan are camptothecin derivatives that are used to treat small cell lung cancer (SCLC). This study compared the toxicities and efficacies of belotecan and topotecan monotherapies in patients with SCLC.Methods. We retrospectively reviewed data from 94 patients with SCLC (with or without prior chemotherapy) who were treated using belotecan monotherapy (n= 59, 188 cycles) or topotecan monotherapy (n= 35, 65 cycles) between September 2003 and December 2011.Results. Thrombocytopenia occurred during 42% and 61.5% of the belotecan and topotecan cycles, respectively (p= 0.007). Significant differences between belotecan and topotecan were also observed for grade 4/5 lung infection (3.2% versus 10.8%, resp.;p= 0.003), all-grade headache (3.2% versus 10.8%, resp.;p= 0.017), and grade 4/5 increased liver enzymes (0.5% versus 4.6%, resp.;p= 0.023). The median TTPDs, CSSs, and OSs were 14 months and 11.6 months (p= 0.646), 10 months and 7 months (p= 0.179), and 34.5 months and 21.4 months (p= 0.914) after belotecan and topotecan monotherapy, respectively.Conclusions. Belotecan monotherapy may be safer than topotecan monotherapy in SCLC patients. And in terms of efficacy, belotecan could be comparable to topotecan monotherapy.
authors.affiliation: Department of Internal Medicine, College of Medicine, Chungnam National University, Daejeon, Republic of Korea.
authors.forename: Yeon Hee
authors.identifier: 0000-0001-9537-1530
authors.initials: YH
authors.lastname: Park
authors.affiliation: Department of Internal Medicine, College of Medicine, Chungnam National University, Daejeon, Republic of Korea.
authors.forename: Chae Uk
authors.initials: CU
authors.lastname: Chung
authors.affiliation: Department of Internal Medicine, College of Medicine, Eulji University, Daejeon, Republic of Korea.
authors.forename: Bo Mi
authors.initials: BM
authors.lastname: Park
authors.affiliation: Department of Internal Medicine, College of Medicine, Chungnam National University, Daejeon, Republic of Korea.
authors.forename: Myoung Rin
authors.initials: MR
authors.lastname: Park
authors.affiliation: Department of Internal Medicine, College of Medicine, Chungnam National University, Daejeon, Republic of Korea.
authors.forename: Dong Il
authors.initials: DI
authors.lastname: Park
authors.affiliation: Department of Internal Medicine, College of Medicine, Chungnam National University, Daejeon, Republic of Korea.
authors.forename: Jae Young
authors.initials: JY
authors.lastname: Moon
authors.affiliation: Department of Internal Medicine, College of Medicine, Chungnam National University, Daejeon, Republic of Korea.
authors.forename: Hee Sun
authors.initials: HS
authors.lastname: Park
authors.affiliation: Department of Radiology, College of Medicine, Chungnam National University, Daejeon, Republic of Korea.
authors.forename: Jin Hwan
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, College of Medicine, Chungnam National University, Daejeon, Republic of Korea.
authors.forename: Sung Soo
authors.initials: SS
authors.lastname: Jung
authors.affiliation: Department of Internal Medicine, College of Medicine, Chungnam National University, Daejeon, Republic of Korea.
authors.forename: Ju Ock
authors.initials: JO
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, College of Medicine, Chungnam National University, Daejeon, Republic of Korea.
authors.forename: Sun Young
authors.initials: SY
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, College of Medicine, Chungnam National University, Daejeon, Republic of Korea.
authors.forename: Jeong Eun
authors.identifier: 0000-0001-6173-2748
authors.initials: JE
authors.lastname: Lee
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002166:Camptothecin / Q000009:adverse effects / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies; D055752:Small Cell Lung Carcinoma / Q000188:drug therapy* / Q000401:mortality; D016019:Survival Analysis; D059004:Topoisomerase I Inhibitors / Q000009:adverse effects*; D019772:Topotecan / Q000009:adverse effects*
chemical_list: D059004:Topoisomerase I Inhibitors; C116963:belotecan; D019772:Topotecan; D002166:Camptothecin