title: Genetic Predisposition to Ischemic Stroke: A Polygenic Risk Score.
abstract: The prediction of genetic predispositions to ischemic stroke (IS) may allow the identification of individuals at elevated risk and thereby prevent IS in clinical practice. Previously developed weighted multilocus genetic risk scores showed limited predictive ability for IS. Here, we investigated the predictive ability of a newer method, polygenic risk score (polyGRS), based on the idea that a few strong signals, as well as several weaker signals, can be collectively informative to determine IS risk.
  
  
  
  We genotyped 13 214 Japanese individuals with IS and 26 470 controls (derivation samples) and generated both multilocus genetic risk scores and polyGRS, using the same derivation data set. The predictive abilities of each scoring system were then assessed using 2 independent sets of Japanese samples (KyushuU and JPJM data sets).
  
  
  
  In both validation data sets, polyGRS was shown to be significantly associated with IS, but weighted multilocus genetic risk scores was not. Comparing the highest with the lowest polyGRS quintile, the odds ratios for IS were 1.75 (95% confidence interval, 1.33-2.31) and 1.99 (95% confidence interval, 1.19-3.33) in the KyushuU and JPJM samples, respectively. Using the KyushuU samples, the addition of polyGRS to a nongenetic risk model resulted in a significant improvement of the predictive ability (net reclassification improvement=0.151; P<0.001).
  
  
  
  The polyGRS was shown to be superior to weighted multilocus genetic risk scores as an IS prediction model. Thus, together with the nongenetic risk factors, polyGRS will provide valuable information for individual risk assessment and management of modifiable risk factors.
authors.affiliation: From the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara). thachiya@iwate-med.ac.jp ashimizu@iwate-med.ac.jp.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Hachiya
authors.affiliation: From the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
authors.forename: Yoichiro
authors.initials: Y
authors.lastname: Kamatani
authors.affiliation: From the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takahashi
authors.affiliation: From the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
authors.forename: Jun
authors.initials: J
authors.lastname: Hata
authors.affiliation: From the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
authors.forename: Ryohei
authors.initials: R
authors.lastname: Furukawa
authors.affiliation: From the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
authors.forename: Yuh
authors.initials: Y
authors.lastname: Shiwa
authors.affiliation: From the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
authors.forename: Taiki
authors.initials: T
authors.lastname: Yamaji
authors.affiliation: From the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
authors.forename: Megumi
authors.initials: M
authors.lastname: Hara
authors.affiliation: From the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
authors.forename: Kozo
authors.initials: K
authors.lastname: Tanno
authors.affiliation: From the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
authors.forename: Hideki
authors.initials: H
authors.lastname: Ohmomo
authors.affiliation: From the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
authors.forename: Kanako
authors.initials: K
authors.lastname: Ono
authors.affiliation: From the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Takashima
authors.affiliation: From the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
authors.forename: Koichi
authors.initials: K
authors.lastname: Matsuda
authors.affiliation: From the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
authors.forename: Kenji
authors.initials: K
authors.lastname: Wakai
authors.affiliation: From the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
authors.forename: Norie
authors.initials: N
authors.lastname: Sawada
authors.affiliation: From the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
authors.forename: Motoki
authors.initials: M
authors.lastname: Iwasaki
authors.affiliation: From the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Yamagishi
authors.affiliation: From the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Ago
authors.affiliation: From the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Ninomiya
authors.affiliation: From the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
authors.forename: Akimune
authors.initials: A
authors.lastname: Fukushima
authors.affiliation: From the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
authors.forename: Atsushi
authors.initials: A
authors.lastname: Hozawa
authors.affiliation: From the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
authors.forename: Naoko
authors.initials: N
authors.lastname: Minegishi
authors.affiliation: From the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
authors.forename: Mamoru
authors.initials: M
authors.lastname: Satoh
authors.affiliation: From the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
authors.forename: Ryujin
authors.initials: R
authors.lastname: Endo
authors.affiliation: From the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
authors.forename: Makoto
authors.initials: M
authors.lastname: Sasaki
authors.affiliation: From the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
authors.forename: Kiyomi
authors.initials: K
authors.lastname: Sakata
authors.affiliation: From the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
authors.forename: Seiichiro
authors.initials: S
authors.lastname: Kobayashi
authors.affiliation: From the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
authors.forename: Kuniaki
authors.initials: K
authors.lastname: Ogasawara
authors.affiliation: From the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
authors.forename: Motoyuki
authors.initials: M
authors.lastname: Nakamura
authors.affiliation: From the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
authors.forename: Jiro
authors.initials: J
authors.lastname: Hitomi
authors.affiliation: From the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
authors.forename: Yoshikuni
authors.initials: Y
authors.lastname: Kita
authors.affiliation: From the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
authors.forename: Keitaro
authors.initials: K
authors.lastname: Tanaka
authors.affiliation: From the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Iso
authors.affiliation: From the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
authors.forename: Takanari
authors.initials: T
authors.lastname: Kitazono
authors.affiliation: From the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
authors.forename: Michiaki
authors.initials: M
authors.lastname: Kubo
authors.affiliation: From the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
authors.forename: Hideo
authors.initials: H
authors.lastname: Tanaka
authors.affiliation: From the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Tsugane
authors.affiliation: From the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Kiyohara
authors.affiliation: From the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
authors.forename: Masayuki
authors.initials: M
authors.lastname: Yamamoto
authors.affiliation: From the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
authors.forename: Kenji
authors.initials: K
authors.lastname: Sobue
authors.affiliation: From the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara). thachiya@iwate-med.ac.jp ashimizu@iwate-med.ac.jp.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Shimizu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics*; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D020412:Multifactorial Inheritance / Q000235:genetics*; D011446:Prospective Studies; D012307:Risk Factors; D020521:Stroke / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics*
keywords: genome-wide association study; genotype; risk assessment; stroke