title: Clinical relevance of colorectal cancer molecular subtypes.
abstract: Colorectal cancer (CRC) is characterized by alteration of critical pathways such TP53 inactivation, BRAF, PI3CA mutations, APC inactivation, KRAS, TGF-β, CTNNB mutations, disregulation of Epithelial to mesnechymal transition (EMT) genes, WNT signaling activation, MYC amplification, and others. Differences in these molecular events results in differences in phenotypic characteristics of CRC, that have been studied and classified by different models of molecular subtypes. It could have potential applications to prognosis, but also to therapeutical approaches of the CRC patients. We review and summarized the different molecular classifications and try to clarify their clinical and therapeutical relevance.
authors.affiliation: Medical Oncology Department, La Paz University Hospital, Autonoma University of Madrid, Paseo de la Castellana 261, 28046, Madrid, Spain. Electronic address: nuria.rodriguez@salud.madrid.org.
authors.forename: Nuria
authors.initials: N
authors.lastname: Rodriguez-Salas
authors.affiliation: Department of Medicine, Medical School, Instituto de Investigaciones Biomédicas Alberto Sols, CSIC-UAM, Calle Arturo Duperier, 4, 28029 Madrid, Spain.
authors.forename: Gema
authors.initials: G
authors.lastname: Dominguez
authors.affiliation: Biochemistry and Molecular Biology Department, Facultad de Ciencias Químicas, Universidad Complutense de Madrid, 28040 Madrid, Spain.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Barderas
authors.affiliation: Molecular Pathology of Cancer and Therapeutic Targets Group, La Paz Hospital Research Institute (IdiPAZ), Paseo de la Castellana 261, 28046, Madrid, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Mendiola
authors.affiliation: Department of Epidemiology, Harvard T.H. Chan School of Public Health and Mongan Institute, Massachusetts General Hospital, Boston, MA, USA.
authors.forename: Xabier
authors.initials: X
authors.lastname: García-Albéniz
authors.affiliation: Medical Oncology Department, Hospital Clínic Barcelona, Translational Genomics and Targeted Therapeutics in Solid Tumors Group, IDIBAPS, University of Barcelona, Barcelona, Spain.
authors.forename: Juan
authors.initials: J
authors.lastname: Maurel
authors.affiliation: Medical Oncology Department, La Paz University Hospital, Autonoma University of Madrid, Paseo de la Castellana 261, 28046, Madrid, Spain; Affiliated to The CIBER Cancer - Instituto de Salud Carlos III, Madrid, Spain.
authors.forename: Jaime Feliu
authors.initials: JF
authors.lastname: Batlle
mesh_terms: D000818:Animals; D015179:Colorectal Neoplasms / Q000145:classification* / Q000235:genetics / Q000378:metabolism / Q000628:therapy*; D006801:Humans; D058990:Molecular Targeted Therapy; D057285:Precision Medicine; D011379:Prognosis; D015398:Signal Transduction
keywords: Colorectal cancer; Molecular subtypes; Personalized treatment