title: [Neuropathology and pathophysiology of Parkinson's disease: Focus on α-synuclein].
abstract: The past 20 years has witnessed tremendous progress in our understanding of Parkinson's disease. It is now well established that α-synuclein, a presynaptic neuronal protein, is not only a marker but also an actor of the disease. In this review, we discuss the advances that have been obtained in neuropathology using α-synuclein immunohistochemistry and the role of this protein in the spread of the disease.
authors.affiliation: Inserm, U913, 44035 Nantes, France.
authors.forename: Alice
authors.initials: A
authors.lastname: Prigent
authors.affiliation: CHU de Nantes, service de neurologie, boulevard Jacques-Monod, 44093 Nantes cedex 01, France.
authors.forename: Arthur
authors.initials: A
authors.lastname: Lionnet
authors.affiliation: Inserm, U913, 44035 Nantes, France; CHU de Nantes, service de neurologie, boulevard Jacques-Monod, 44093 Nantes cedex 01, France; Université de Nantes, 44035 Nantes, France.
authors.forename: Anne-Gaëlle
authors.initials: AG
authors.lastname: Corbillé
authors.affiliation: Inserm, U913, 44035 Nantes, France; CHU de Nantes, service de neurologie, boulevard Jacques-Monod, 44093 Nantes cedex 01, France; Université de Nantes, 44035 Nantes, France. Electronic address: derkinderenp@yahoo.fr.
authors.forename: Pascal
authors.initials: P
authors.lastname: Derkinderen
mesh_terms: D001923:Brain Chemistry; D017615:Enteric Nervous System / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D007150:Immunohistochemistry; D016631:Lewy Bodies / Q000737:chemistry; D008959:Models, Neurological; D009420:Nervous System / Q000378:metabolism / Q000503:physiopathology*; D009474:Neurons / Q000378:metabolism; D009928:Organ Specificity; D018384:Oxidative Stress; D010300:Parkinson Disease / Q000235:genetics / Q000503:physiopathology*; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D066148:Spinal Cord Dorsal Horn / Q000378:metabolism / Q000503:physiopathology; D014630:Vagus Nerve / Q000378:metabolism / Q000503:physiopathology; D051844:alpha-Synuclein / Q000172:deficiency / Q000235:genetics / Q000502:physiology*
chemical_list: D051844:alpha-Synuclein