title: Gold-Catalyzed Direct Oxidative Arylation with Boron Coupling Partners.
abstract: An efficient synthesis of biaryls through a gold-catalyzed oxidative cross-coupling of arenes with strong electron-deprived aryl boronates is presented herein. Regio- and chemocontrol are achieved by the selective activation of these coupling partners by gold at different oxidation states. Under reaction conditions devoid of basic additives or directing groups, the role of acetato ligand as an internal base has been revealed as a key parameter for expanding the reaction scope in these transformations.
authors.affiliation: Department of Chemistry, University of Zürich, Winterthurerstrasse 190, 8057, Zürich, Switzerland.
authors.forename: Manuel
authors.initials: M
authors.lastname: Hofer
authors.affiliation: Department of Chemistry, University of Zürich, Winterthurerstrasse 190, 8057, Zürich, Switzerland.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Genoux
authors.affiliation: Department of Chemistry, University of Zürich, Winterthurerstrasse 190, 8057, Zürich, Switzerland.
authors.forename: Roopender
authors.initials: R
authors.lastname: Kumar
authors.affiliation: Department of Chemistry, University of Zürich, Winterthurerstrasse 190, 8057, Zürich, Switzerland.
authors.forename: Cristina
authors.initials: C
authors.lastname: Nevado
keywords: arylation; cross-coupling; gold; homogeneous catalysis; reaction mechanisms