title: Pulmonary lymphoepithelioma-like carcinoma with echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK) fusion gene.
abstract: A pulmonary lymphoepithelioma-like carcinoma (PLELC) is similar to a lymphoepithelioma, a subtype of nasopharyngeal carcinoma and commonly associated with Epstein-Barr virus infection which is a rare tumour and classified in the group of "other and unclassified carcinoma" in the latest 2015 World Health Organization (WHO) classification. Some reports of lymphoepithelioma-like carcinoma (LELC) have noted an epidermal growth factor receptor (EGFR) mutation, whereas none have noted a mutation of the echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK) fusion gene. This is the first reported case of PLELC with ALK rearrangement. A 76-year-old woman underwent a right lower lobectomy and complicated partial resection of the upper lobe with lymph node dissection under complete thoracoscopic approach. A histopathological diagnosis of PLELC was made and the stage was classified as T1aN1(#12l) M0, pl0, G2, Ly1, V1. The results of both ALK immunohistochemistry and EML4-ALK fusion gene on fluorescence in situ hybridization (FISH) examinations were positive; however, EGFR mutational analysis results showed wild-type mutation.
authors.affiliation: Department of General Thoracic Surgery National Hospital Organization Toneyama Hospital Osaka Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Ose
authors.affiliation: Department of General Thoracic Surgery National Hospital Organization Toneyama Hospital Osaka Japan.
authors.forename: Teruka
authors.initials: T
authors.lastname: Kawai
authors.affiliation: Department of General Thoracic Surgery National Hospital Organization Toneyama Hospital Osaka Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Ishida
authors.affiliation: Department of General Thoracic Surgery National Hospital Organization Toneyama Hospital Osaka Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Kobori
authors.affiliation: Department of General Thoracic Surgery National Hospital Organization Toneyama Hospital Osaka Japan.
authors.forename: Yukiyasu
authors.initials: Y
authors.lastname: Takeuchi
authors.affiliation: Department of Pathology National Hospital Organization Toneyama Hospital Osaka Japan.
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Senba
keywords: ALK; EML4‐ALK; lung; lymphoepithelioma‐like carcinoma; pulmonary