title: Vertex-wise examination of depressive symptom dimensions and brain volumes in older adults.
abstract: Differences in brain volumes have commonly been reported in older adults with both subthreshold and major depression. Few studies have examined the association between specific symptom dimensions of depression and brain volumes. This study used vertex-wise analyses to examine the association between specific symptom dimensions of depression and brain volumes in older adults with subthreshold levels of depressive symptoms. Forty-three community-dwelling adults between the ages of 55 and 81 years underwent a structural Magnetic Resonance Imaging scan and completed the Center for Epidemiologic Studies Depression Scale (CES-D). Vertex-wise analyses were conducted using Freesurfer Imaging Suite to examine the relationship between CES-D subscale scores and gray matter volumes while controlling for sex, age, and education. We found distinct associations between depressed mood, somatic symptoms, and lack of positive affect subscales with regional volumes, including primarily positive relationships in temporal regions and a negative association with the lingual gyrus. The relationship between higher depressed mood subscale scores and larger volumes in the left inferior temporal lobe withstood Monte-Carlo correction for multiple comparisons. Results from this preliminary study highlight the importance of examining depression on a symptom dimension level and identify brain regions that may be important in larger studies of depression.
authors.affiliation: Department of Clinical and Health Psychology, University of Florida, PO Box 100165, Gainesville, FL 32610-0165, USA.
authors.forename: Molly E
authors.initials: ME
authors.lastname: McLaren
authors.affiliation: Department of Clinical and Health Psychology, University of Florida, PO Box 100165, Gainesville, FL 32610-0165, USA.
authors.forename: Sarah M
authors.initials: SM
authors.lastname: Szymkowicz
authors.affiliation: Department of Clinical and Health Psychology, University of Florida, PO Box 100165, Gainesville, FL 32610-0165, USA; Center for Cognitive Aging and Memory, McKnight Brain Institute, 1149 Newell Drive, Gainesville, FL 32611, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: O'Shea
authors.affiliation: Department of Clinical and Health Psychology, University of Florida, PO Box 100165, Gainesville, FL 32610-0165, USA; Center for Cognitive Aging and Memory, McKnight Brain Institute, 1149 Newell Drive, Gainesville, FL 32611, USA; Department of Neuroscience, University of Florida, PO Box 100244, Gainesville, FL 32610, USA.
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Woods
authors.affiliation: Department of Aging & Geriartric Research, University of Florida, 2004 Mowry Rd, Gainesville, FL, USA.
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Anton
authors.affiliation: Department of Clinical and Health Psychology, University of Florida, PO Box 100165, Gainesville, FL 32610-0165, USA; Center for Cognitive Aging and Memory, McKnight Brain Institute, 1149 Newell Drive, Gainesville, FL 32611, USA; Department of Neuroscience, University of Florida, PO Box 100244, Gainesville, FL 32610, USA. Electronic address: vonetta@phhp.ufl.edu.
authors.forename: Vonetta M
authors.initials: VM
authors.lastname: Dotson
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology*; D003863:Depression / Q000000981:diagnostic imaging / Q000473:pathology*; D003865:Major Depressive Disorder / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D066128:Gray Matter / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009929:Organ Size
keywords: Aging; Brain; Depressive symptoms; MRI; Symptom dimensions; Vertex-wise analysis