title: Experimental animal model in a histological study of drug-induced gingival overgrowth.
abstract: Gingival overgrowth (GO) is a pathology with important aesthetic and functional implications and with a multifactorial pathogenesis. Incriminated etiological factors include antihypertensive, antiepileptic and immunosuppressant medication. We aimed to evaluate the induction of gingival overgrowth on experimental rats, depending on the drug type, dose and duration. In the research conducted by us, the increase in gingival tissue production occurred gradually, depending on the administered medication and the time elapsed after its start. The study conducted shows that experimentally induced gingival overgrowth of the administered drugs is made possible by altering tissue homeostasis through altering the fibrocyte cell populations involved in the tissular turnover as well as those involved in the inflammatory process. A better understanding of the pathogenesis of this undesirable effect may lead to the development of improved management strategies for preventing it, or reducing it through non-surgical methods.
authors.affiliation: Department of Histology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania; scraitoiu@yahoo.com.
authors.forename: Adelina Gabriela
authors.initials: AG
authors.lastname: Bobic
authors.forename: Ştefania
authors.initials: Ş
authors.lastname: CrăiŢoiu
authors.forename: Roxana Maria
authors.initials: RM
authors.lastname: Pascu
authors.forename: Ileana Cristiana
authors.initials: IC
authors.lastname: Croitoru
authors.forename: Marius
authors.initials: M
authors.lastname: Matei
authors.forename: Florian
authors.initials: F
authors.lastname: Obădan
authors.forename: Monica Mihaela
authors.initials: MM
authors.lastname: CrăiŢoiu
mesh_terms: D000818:Animals; D019214:Gingival Overgrowth / Q000139:chemically induced* / Q000473:pathology; D023421:Models, Animal; D051381:Rats; D017208:Rats, Wistar