title: Prevalence of hepatitis E virus infection among blood donors in mainland China: a meta-analysis.
abstract: The risk of hepatitis E virus (HEV) infection from blood transfusion has raised increasing concern in many countries. Several transfusion-transmitted cases have been described in the United Kingdom and Japan. The objective was to investigate the prevalence of HEV infection among Chinese blood donors and analyze the potential risk of HEV infection through blood transfusion in China.
  
  
  
  Major English and Chinese research databases were used as background research for the study of locations, years, and the number of HEV infections among blood donors in China. The pooled, estimated rate of HEV infection was calculated. Subgroup analyses, for age, sex, and alanine aminotransferase (ALT) levels were performed using software for comprehensive meta-analysis.
  
  
  
  The pooled rates of anti-HEV IgM- and anti-HEV IgG-positive donations were 1.09% (95% confidence interval [CI], 0.95%-1.26%) and 30% (95% CI, 25%-34%), respectively. The prevalence of anti-HEV IgM was significantly higher in donors with elevated ALT (4.34%) compared with the rate in donors with normal ALT (1.35%; χ2= 39.66, p < 0.01). The anti-HEV IgM and IgG rates were higher in the Southwest region (1.58 and 41%, respectively) compared to the rates in other regions of China (chi-square test, p < 0.05). The anti-HEV IgG rate was also significantly higher in donors 30 years and older compared with donors between 18 and 29 years of age (39% vs. 22%, respectively; χ2= 1457.10, p < 0.01). Genetic analysis of HEV from RNA-positive donors indicated that the majority of HEV infections were Genotype 1 (19/33 = 58%), while the remaining 14 isolates were Genotype 4 (14/33 = 42%; χ2= 0.758, p > 0.05).
  
  
  
  Qualified donations after routine blood donor screening still carry a potential risk for transmitting HEV. The major genotypes in Chinese donors in this study were Genotypes 1 and 4.
authors.affiliation: Qingdao University Medical College, Qingdao, ShanDong Province, China.|Qingdao Blood Centre, Qingdao, ShanDong Province, China.
authors.forename: Longmu
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Qingdao Blood Centre, Qingdao, ShanDong Province, China.
authors.forename: Shuxian
authors.initials: S
authors.lastname: Jiao
authors.affiliation: Qingdao Blood Centre, Qingdao, ShanDong Province, China.
authors.forename: Zhongsi
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Qingdao Blood Centre, Qingdao, ShanDong Province, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Xu
authors.affiliation: Qingdao Blood Centre, Qingdao, ShanDong Province, China.
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.affiliation: Qingdao Blood Centre, Qingdao, ShanDong Province, China.
authors.forename: Qiuxia
authors.initials: Q
authors.lastname: Feng
authors.affiliation: Qingdao Blood Centre, Qingdao, ShanDong Province, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Qingdao Blood Centre, Qingdao, ShanDong Province, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Hou
authors.affiliation: NYU Tandon School of Engineering, New York, New York.
authors.forename: Shuyi
authors.initials: S
authors.lastname: He
authors.affiliation: Clinical Affairs, Immucor, Inc., Norcross, Georgia.
authors.forename: John
authors.initials: J
authors.lastname: Saldanha
authors.affiliation: Qingdao University Medical College, Qingdao, ShanDong Province, China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Wang
authors.affiliation: Qingdao University Medical College, Qingdao, ShanDong Province, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
mesh_terms: D000367:Age Factors; D000410:Alanine Transaminase / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood; D001782:Blood Donors; D002681:China / Q000453:epidemiology; D016208:Databases, Factual; D046148:Donor Selection; D005260:Female; D016751:Hepatitis E / Q000097:blood / Q000453:epidemiology / Q000635:transmission; D016752:Hepatitis E virus; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D015995:Prevalence; D012737:Sex Factors
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D000410:Alanine Transaminase