title: [Effect of Rabbit Anti-human Thymocyte Immunoglobulin Combined with Cyclosporin A on Severe Aplastic Anemia].
abstract: OBJECTIVE
  To study the efficacy and safety of anti-human thymocyte immunoglobulin(ATG-F) combined with cyclosporin A(CsA) on patients with severe aplastic anemia (SSA), so as to provide support for clinical work.
  
  
  METHODS
  From January 2010 to December 2015, 78 patients with SAA admitted in our hospital were divided into 2 groups: ATG-F+CsA group(40 cases) and ATG-F group(38 cases). After treatment for 6 months, the effective rate, side reaction rate and time of effect initiation were compared between 2 groups. The follow-up results were compared between 2 groups.
  
  
  RESULTS
  The effective rate and side reaction rate in ATG-F+CsA group were 100.00% and 32.50% respectively, those in ATG-F group were 94.74% and 44.74% respectively and without statistical significant difference(P>0.05). In ATG-F+CsA group, the time of effect initiation in cured patients, remission and obvious inprovement were (44.9±15.4) d, (68.8±15.9) d and (85.4±17.6) d; in ATG-F group, patients with those were (59.6±11.5) d, (94.7±17.8) d and (119.8±21.4) d respectively, the difference showed statistical significance(P<0.05). The follow-up results were not statistically significantly different between 2 groups(P>0.05).
  
  
  CONCLUSIONS
  ATG-F combined with CsA can shorten the time of effect initiation, and demonstrates reliable safety.
authors.affiliation: Department of Hematology, Qinghai University Affiliated Hospital, Xinning 810001, Qinghai Province, China. E-mail: luoweili922@163.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Luo
authors.affiliation: Department of Hematology, Qinghai University Affiliated Hospital, Xinning 810001, Qinghai Province, China.
authors.forename: Lin-Hua
authors.initials: LH
authors.lastname: Ji
authors.affiliation: Department of Hematology, Qinghai University Affiliated Hospital, Xinning 810001, Qinghai Province, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Geng
authors.affiliation: Department of Hematology, Qinghai University Affiliated Hospital, Xinning 810001, Qinghai Province, China.
authors.forename: Xiao-Jing
authors.initials: XJ
authors.lastname: Ma
authors.affiliation: Department of Hematology, Qinghai University Affiliated Hospital, Xinning 810001, Qinghai Province, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Xiong
authors.affiliation: Department of Hematology, Qinghai University Affiliated Hospital, Xinning 810001, Qinghai Province, China.
authors.forename: Qi-Chao
authors.initials: QC
authors.lastname: Yin
authors.affiliation: Department of Hematology, Qinghai University Affiliated Hospital, Xinning 810001, Qinghai Province, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Ma
mesh_terms: D000293:Adolescent; D000741:Anemia, Aplastic; D000818:Animals; D000961:Antilymphocyte Serum; D016572:Cyclosporine; D006760:Hospitalization; D006801:Humans; D007166:Immunosuppressive Agents; D011817:Rabbits; D060168:Thymocytes; D016896:Treatment Outcome
chemical_list: D000961:Antilymphocyte Serum; D007166:Immunosuppressive Agents; D016572:Cyclosporine; C512542:thymoglobulin