title: Minichromosome maintenance protein 7 and geminin expression: Prognostic value in laryngeal squamous cell carcinoma in patients treated with radiotherapy and cetuximab.
abstract: Minichromosome maintenance protein 7 (MCM7) is a downstream of human epidermal growth receptor (HER1) signaling. We examined MCM7, geminin, and HER1 expression in patients with laryngeal squamous cell carcinoma (SCC) treated with radiotherapy and cetuximab.
  
  
  
  MCM7, geminin, and HER1 were evaluated by immunohistochemistry on 61 patients with laryngeal SCC. The follow-up (median, 32.1 months; range, 2-139 months) went from the beginning of therapy to tumor progression-free survival (PFS) and death (overall survival [OS]).
  
  
  
  MCM7, but not geminin, was associated only with HER1 expression, whereas no association was found with other clinicopathological characteristics. Patients with MCM7 high - geminin high and MCM7 high - geminin low tumor status had a risk of progression 3.1 times and 17.7 times greater, respectively, than patients with MCM7 low - geminin high tumor status. Tumor site, MCM7, and geminin were independent determinants of PFS, whereas MCM7 was an independent prognostic marker of OS.
  
  
  
  MCM7-geminin tumor status may be prognostic for patients with laryngeal SCC treated with cetuximab and radiotherapy. © 2016 Wiley Periodicals, Inc. Head Neck 39: 684-693, 2017.
authors.affiliation: Institute of Otolaryngology, Head and Neck Surgery, Catholic University of Sacred Heart, Rome, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Almadori
authors.affiliation: Institute of Anatomic Pathology, Catholic University of Sacred Heart, Rome, Italy.
authors.forename: Libero
authors.initials: L
authors.lastname: Lauriola
authors.affiliation: Institute of Anatomic Pathology, Catholic University of Sacred Heart, Rome, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Coli
authors.affiliation: Institute of Otolaryngology, Head and Neck Surgery, Catholic University of Sacred Heart, Rome, Italy.
authors.forename: Francesco
authors.identifier: 0000-0001-6261-2772
authors.initials: F
authors.lastname: Bussu
authors.affiliation: Institute of Otolaryngology, Head and Neck Surgery, Catholic University of Sacred Heart, Rome, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Gallus
authors.affiliation: Institute of Anatomic Pathology, Catholic University of Sacred Heart, Rome, Italy.
authors.forename: Domenico
authors.initials: D
authors.lastname: Scannone
authors.affiliation: Institute of Radiotherapy, Catholic University of Sacred Heart, Rome, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Valentini
authors.affiliation: Institute of Otolaryngology, Head and Neck Surgery, Catholic University of Sacred Heart, Rome, Italy.
authors.forename: Gaetano
authors.initials: G
authors.lastname: Paludetti
authors.affiliation: Laboratory of Head and Neck Center Biology, Department of Otolaryngology, Head and Neck Surgery, the University of Michigan, Ann Arbor, Michigan.
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Carey
authors.affiliation: Institute of Histology, Catholic University of Sacred Heart, Rome, Italy.
authors.forename: Franco O
authors.initials: FO
authors.lastname: Ranelletti
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D000068818:Cetuximab / Q000008:administration & dosage*; D059248:Chemoradiotherapy / Q000379:methods*; D015331:Cohort Studies; D018572:Disease-Free Survival; D005260:Female; D064248:Geminin / Q000378:metabolism*; D006801:Humans; D053208:Kaplan-Meier Estimate; D007822:Laryngeal Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D064168:Minichromosome Maintenance Complex Component 7 / Q000378:metabolism*; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D059351:Organ Sparing Treatments; D011379:Prognosis; D012189:Retrospective Studies; D018570:Risk Assessment; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; C577995:GMNN protein, human; D064248:Geminin; C101624:MCM7 protein, human; D064168:Minichromosome Maintenance Complex Component 7; D000068818:Cetuximab
keywords: cetuximab; geminin; laryngeal squamous cell carcinoma; mini-chromosome maintenance protein 7 (MCM7); radiotherapy