title: In vivo liver visualizations with magnetic particle imaging based on the calibration measurement approach.
abstract: Magnetic particle imaging (MPI) facilitates the rapid determination of 3D in vivo magnetic nanoparticle distributions. In this work, liver MPI following intravenous injections of ferucarbotran (Resovist®) was studied. The image reconstruction was based on a calibration measurement, the so called system function. The application of an enhanced system function sample reflecting the particle mobility and aggregation status of ferucarbotran resulted in significantly improved image reconstructions. The finding was supported by characterizations of different ferucarbotran compositions with the magnetorelaxometry and magnetic particle spectroscopy technique. For instance, similar results were obtained between ferucarbotran embedded in freeze-dried mannitol sugar and liver tissue harvested after a ferucarbotran injection. In addition, the combination of multiple shifted measurement patches for a joint reconstruction of the MPI data enlarged the field of view and increased the covering of liver MPI on magnetic resonance images noticeably.
authors.affiliation: Department for Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Dieckhoff
authors.forename: M G
authors.initials: MG
authors.lastname: Kaul
authors.forename: T
authors.initials: T
authors.lastname: Mummert
authors.forename: C
authors.initials: C
authors.lastname: Jung
authors.forename: J
authors.initials: J
authors.lastname: Salamon
authors.forename: G
authors.initials: G
authors.lastname: Adam
authors.forename: T
authors.initials: T
authors.lastname: Knopp
authors.forename: F
authors.initials: F
authors.lastname: Ludwig
authors.forename: C
authors.initials: C
authors.lastname: Balceris
authors.forename: H
authors.initials: H
authors.lastname: Ittrich
mesh_terms: D000818:Animals; D002138:Calibration; D003287:Contrast Media / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D003911:Dextrans / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008099:Liver / Q000000981:diagnostic imaging* / Q000378:metabolism; D008279:Magnetic Resonance Imaging / Q000379:methods*; D058185:Magnetite Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D051379:Mice; D057054:Molecular Imaging / Q000379:methods*; D014018:Tissue Distribution
chemical_list: D003287:Contrast Media; D003911:Dextrans; D058185:Magnetite Nanoparticles; C065507:ferumoxides