title: Nanostructured lipid carriers: versatile oral delivery vehicle.
abstract: Oral delivery is the most accepted and economical route for drug administration and leads to substantial reduction in dosing frequency. However, this route still remains a challenge for the pharmaceutical industry due to poorly soluble and permeable drugs leading to poor oral bioavailability. Incorporating bioactives into nanostructured lipid carriers (NLCs) has helped in boosting their therapeutic functionality and prolonged release from these carrier systems thus providing improved pharmacokinetic parameters. The present review provides an overview of noteworthy studies reporting impending benefits of NLCs in oral delivery and highlights recent advancements for developing engineered NLCs either by conjugating polymers over their surface or modifying their charge to overcome the mucosal barrier of GI tract for active transport across intestinal membrane.
authors.affiliation: Department of Pharmaceutics, JCDM College of Pharmacy, Sirsa 125055, Haryana, India; Department of Pharmaceutics, JCDM College of Pharmacy, Sirsa 125055, Haryana, India.
authors.forename: Neelam
authors.initials: N
authors.lastname: Poonia
authors.affiliation: Department of Pharmaceutical Chemistry, CT Institute of Pharmaceutical Sciences, Jalandhar 144020, Punjab, India; Department of Pharmaceutical Chemistry, CT Institute of Pharmaceutical Sciences, Jalandhar 144020, Punjab, India.
authors.forename: Rajeev
authors.initials: R
authors.lastname: Kharb
authors.affiliation: Department of Pharmaceutical Chemistry, JCDM College of Pharmacy, Sirsa 125055, Haryana, India; Department of Pharmaceutical Chemistry, JCDM College of Pharmacy, Sirsa 125055, Haryana, India.
authors.forename: Viney
authors.initials: V
authors.lastname: Lather
authors.affiliation: Department of Pharmaceutics, JCDM College of Pharmacy, Sirsa 125055, Haryana, India; Department of Pharmaceutics, JCDM College of Pharmacy, Sirsa 125055, Haryana, India.
authors.forename: Deepti
authors.initials: D
authors.lastname: Pandita
keywords: controlled drug release; gene/drug delivery; nanoparticles