title: Fine-needle aspiration cytology (FNAC): is it useful in preoperative diagnosis of parotid gland lesions?
abstract: BACKGROUND
  Salivary gland tumors are an uncommon entity and its histopathology is highly varied due to heterogeneous cellular composition. The role of the preoperative fine-needle aspiration cytology (FNAC) remains controversial. The purpose of this study is to compare the cytologic findings of salivary gland lesions with the histologic diagnoses, in order to assess the usefulness and accuracy of fine-needle aspiration cytology in the diagnosis of parotid gland tumors.
  
  
  METHODS
  A retrospective study was performed, regarding patients (n = 65) submitted to surgery for the treatment of parotid gland disease, who had performed preoperative FNAC, in our department between 2002 and 2012. A histologic diagnosis was considered as the gold standard for the assessment of sensitivity and specificity of FNAC. A cytohistologic correlation was done and appropriate statistical tests were applied.
  
  
  RESULTS
  Concordance between FNAC and histological specimen analysis was 78%. FNAC specificity was 82% and sensitivity was 71%. Positive and negative predictive values were 65% and 86% and positive likelihood ratio and negative likelihood ratio were 3.92 and 0.35, respectively. The diagnostic accuracy for this test was 78%.
  
  
  CONCLUSIONS
  Preoperative FNAC of parotid lesions is reasonably accurate and useful in diagnosing benign from malignant lesions and in planning appropriate approach for treatment.
authors.affiliation: a Department of Plastic and Reconstructive Surgery , Centro Hospitalar S. João , Porto , Portugal.|b Department of Plastic and Reconstructive Surgery, Faculty of Medicine , University of Porto , Porto , Portugal.|c Department of Pediatrics, Centro Hospitalar de Vila Nova de Gaia/Espinho, R. Dr. Francisco Sa Carneiro, Vila Nova de Gaia, Portugal , Vila Nova de Gaia , Portugal.
authors.forename: Inês
authors.initials: I
authors.lastname: Correia-Sá
authors.affiliation: c Department of Pediatrics, Centro Hospitalar de Vila Nova de Gaia/Espinho, R. Dr. Francisco Sa Carneiro, Vila Nova de Gaia, Portugal , Vila Nova de Gaia , Portugal.
authors.forename: Mário
authors.initials: M
authors.lastname: Correia-Sá
authors.affiliation: a Department of Plastic and Reconstructive Surgery , Centro Hospitalar S. João , Porto , Portugal.|b Department of Plastic and Reconstructive Surgery, Faculty of Medicine , University of Porto , Porto , Portugal.
authors.forename: Pedro
authors.initials: P
authors.lastname: Costa-Ferreira
authors.affiliation: a Department of Plastic and Reconstructive Surgery , Centro Hospitalar S. João , Porto , Portugal.
authors.forename: Álvaro
authors.initials: Á
authors.lastname: Silva
authors.affiliation: a Department of Plastic and Reconstructive Surgery , Centro Hospitalar S. João , Porto , Portugal.|b Department of Plastic and Reconstructive Surgery, Faculty of Medicine , University of Porto , Porto , Portugal.
authors.forename: Marisa
authors.initials: M
authors.lastname: Marques
mesh_terms: D008949:Adenoma, Pleomorphic / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery*; D000328:Adult; D000368:Aged; D044963:Biopsy, Fine-Needle / Q000379:methods*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016013:Likelihood Functions; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D010306:Parotid Gland / Q000601:surgery*; D010307:Parotid Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery*; D011237:Predictive Value of Tests; D011300:Preoperative Care / Q000379:methods; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods; D018608:Ultrasonography, Doppler / Q000379:methods
keywords: FNAC; Parotid; tumor