title: Assessments of sensory plasticity after spinal cord injury across species.
abstract: Spinal cord injury (SCI) is a multifaceted phenomenon associated with alterations in both motor function and sensory function. A majority of patients with SCI report sensory disturbances, including not only loss of sensation, but in many cases enhanced abnormal sensation, dysesthesia and pain. Development of therapeutics to treat these abnormal sensory changes require common measurement tools that can enable cross-species translation from animal models to human patients. We review the current literature on translational nociception/pain measurement in SCI and discuss areas for further development. Although a number of tools exist for measuring both segmental and affective sensory changes, we conclude that there is a pressing need for better, integrative measurement of nociception/pain outcomes across species to enhance precise therapeutic innovation for sensory dysfunction in SCI.
authors.affiliation: Weill Institute for Neurosciences, Brain and Spinal Injury Center (BASIC), Department of Neurological Surgery, University of California, San Francisco, CA, USA. Electronic address: jenny.haefeli@ucsf.edu.
authors.forename: Jenny
authors.initials: J
authors.lastname: Haefeli
authors.affiliation: Weill Institute for Neurosciences, Brain and Spinal Injury Center (BASIC), Department of Neurological Surgery, University of California, San Francisco, CA, USA. Electronic address: russell.huie@ucsf.edu.
authors.forename: J Russell
authors.initials: JR
authors.lastname: Huie
authors.affiliation: Weill Institute for Neurosciences, Brain and Spinal Injury Center (BASIC), Department of Neurological Surgery, University of California, San Francisco, CA, USA. Electronic address: kazuhito.morioka@ucsf.edu.
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Morioka
authors.affiliation: Weill Institute for Neurosciences, Brain and Spinal Injury Center (BASIC), Department of Neurological Surgery, University of California, San Francisco, CA, USA; San Francisco Veteran's Affairs Medical Center, San Francisco, CA, USA. Electronic address: adam.ferguson@ucsf.edu.
authors.forename: Adam R
authors.initials: AR
authors.lastname: Ferguson
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D015415:Biomarkers / Q000032:analysis; D003213:Conditioning, Psychological; D006801:Humans; D009473:Neuronal Plasticity; D059225:Nociception; D010146:Pain / Q000503:physiopathology; D010147:Pain Measurement / Q000379:methods*; D012018:Reflex; D013045:Species Specificity; D013119:Spinal Cord Injuries / Q000503:physiopathology* / Q000523:psychology; D057170:Translational Research, Biomedical
chemical_list: D015415:Biomarkers
keywords: Common data elements; Pain; Sensory assessment; Spinal cord injury