title: Cadiolides J-M, antibacterial polyphenyl butenolides from the Korean tunicate Pseudodistoma antinboja.
abstract: Activity-guided fractionations of the tunicate Pseudodistoma antinboja yielded four new compounds of the cadiolide class (cadiolides J-M, 1, 3-5) along with a known one (cadiolide H, 2). The structures were defined by spectroscopic methods including X-ray crystallographic analysis. These compounds were evaluated for their antibacterial activity and exhibited potent antibacterial activity against all of the drug resistant strains tested with MICs comparable to those of marketed drugs such as vancomycin and linezolid.
authors.affiliation: Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 08826, Republic of Korea.
authors.forename: Weihong
authors.initials: W
authors.lastname: Wang
authors.affiliation: Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 08826, Republic of Korea.
authors.forename: Hiyoung
authors.initials: H
authors.lastname: Kim
authors.affiliation: Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 08826, Republic of Korea.
authors.forename: Rahul S
authors.initials: RS
authors.lastname: Patil
authors.affiliation: Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 08826, Republic of Korea.
authors.forename: Awadut G
authors.initials: AG
authors.lastname: Giri
authors.affiliation: Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 08826, Republic of Korea.
authors.forename: Dong Hwan
authors.initials: DH
authors.lastname: Won
authors.affiliation: Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 08826, Republic of Korea.
authors.forename: Dongyup
authors.initials: D
authors.lastname: Hahn
authors.affiliation: Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 08826, Republic of Korea.
authors.forename: Youjung
authors.initials: Y
authors.lastname: Sung
authors.affiliation: Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 08826, Republic of Korea.
authors.forename: Jusung
authors.initials: J
authors.lastname: Lee
authors.affiliation: College of Pharmacy, Yeungnam University, 214-1 Dae-dong, Gyeongsan 38541, Republic of Korea.
authors.forename: Hyukjae
authors.initials: H
authors.lastname: Choi
authors.affiliation: Department of Chemistry and Nano Science, Global Top 5 Program, Ewha Womans University, Seoul 03760, Republic of Korea.
authors.forename: Sang-Jip
authors.initials: SJ
authors.lastname: Nam
authors.affiliation: Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 08826, Republic of Korea; Research Institute of Oceanography, Seoul National University, NS-80, Seoul 08826, Republic of Korea. Electronic address: hjkang@snu.ac.kr.
authors.forename: Heonjoong
authors.initials: H
authors.lastname: Kang
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D024881:Drug Resistance, Bacterial / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D056910:Republic of Korea; D013329:Structure-Activity Relationship; D014561:Urochordata / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; C004511:butenolide; D015107:4-Butyrolactone
keywords: Antibacterial activity; Pseudodistoma antinboja; Tunicate