title: The perspective of celiac disease patients on emerging treatment options and non-celiac gluten sensitivity.
abstract: BACKGROUND
  Non-celiac gluten sensitivity (NCGS) and emerging treatment options are hot topics in the celiac disease (CeD) scientific literature. However, very little is known about the perspective on these issues of CeD patients.
  
  
  METHODS
  We performed a large patient survey among unselected CeD patients in Switzerland.
  
  
  RESULTS
  A total of 1689 patients were analyzed. 57.5% have previously heard of NCGS. 64.5% believe in the existence of this entity. Regarding a potential influence of NCGS on CeD awareness, 31.7% show a positive and 27.5% a negative perception. Patients with prior use of alternative medicine and women more often have heard of and believe in the existence of NCGS vs. those never having used alternative methods and men, respectively (66.9 vs. 56.9%, p=0.001 and 78.5 vs. 69.0%, p=0.001; 60.7 vs. 44.2%, p<0.001 and 71.0 vs. 60.8%, p=0.002). Women and patients ≥30 years more often show a negative attitude towards NCGS (32.2% vs. 24.8%, p=0.024 and 32.2% vs. 24.2%, p=0.018). With regard to emerging treatment options for CeD, 43.3% have previously heard of novel agents, more women than men (46.0 vs. 38.0%, p=0.019).
  
  
  CONCLUSIONS
  Perception of and attitude towards NCGS differ depending on sex, age and prior use of alternative medicine. Knowledge of the progress towards emerging treatment options is currently limited.
authors.affiliation: Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
authors.forename: Thomas
authors.initials: T
authors.lastname: Greuter
authors.affiliation: Division of Gastroenterology and Hepatology, Triemli Hospital Zurich, Zurich, Switzerland.
authors.forename: Sandra
authors.initials: S
authors.lastname: Schmidlin
authors.affiliation: Division of Gastroenterology and Hepatology, Triemli Hospital Zurich, Zurich, Switzerland.
authors.forename: Jaqueline
authors.initials: J
authors.lastname: Lattmann
authors.affiliation: Division of Gastroenterology and Hepatology, Triemli Hospital Zurich, Zurich, Switzerland.
authors.forename: Matthias
authors.initials: M
authors.lastname: Stotz
authors.affiliation: Division of Gastroenterology and Hepatology, Triemli Hospital Zurich, Zurich, Switzerland.
authors.forename: Romina
authors.initials: R
authors.lastname: Lehmann
authors.affiliation: Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
authors.forename: Jonas
authors.initials: J
authors.lastname: Zeitz
authors.affiliation: Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
authors.forename: Michael
authors.initials: M
authors.lastname: Scharl
authors.affiliation: Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Misselwitz
authors.affiliation: Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
authors.forename: Daniel
authors.initials: D
authors.lastname: Pohl
authors.affiliation: Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
authors.forename: Michael
authors.initials: M
authors.lastname: Fried
authors.affiliation: Division of Gastroenterology and Hepatology, Spital Tiefenau, Bern, Switzerland.
authors.forename: Radu
authors.initials: R
authors.lastname: Tutuian
authors.affiliation: Pediatric Gastroenterology and Nutrition, MassGeneral Hospital for Children, Boston, MA, USA.
authors.forename: Alessio
authors.initials: A
authors.lastname: Fasano
authors.affiliation: Division of Gastroenterology and Hepatology, University Hospital Lausanne-CHUV, Lausanne, Switzerland.
authors.forename: Alain M
authors.initials: AM
authors.lastname: Schoepfer
authors.affiliation: Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
authors.forename: Gerhard
authors.initials: G
authors.lastname: Rogler
authors.affiliation: Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
authors.forename: Luc
authors.initials: L
authors.lastname: Biedermann
authors.affiliation: Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland; Division of Gastroenterology and Hepatology, Triemli Hospital Zurich, Zurich, Switzerland. Electronic address: stephan.vavricka@triemli.zuerich.ch.
authors.forename: Stephan R
authors.initials: SR
authors.lastname: Vavricka
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002446:Celiac Disease / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D055050:Diet, Gluten-Free; D019468:Disease Management; D005260:Female; D005512:Food Hypersensitivity / Q000628:therapy*; D005983:Glutens / Q000009:adverse effects*; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D011795:Surveys and Questionnaires; D013557:Switzerland; D055815:Young Adult
chemical_list: D005983:Glutens
keywords: Celiac disease; Emerging treatment options; Non-celiac gluten sensitivity; Patient’s perspective