title: Impulsive oculomotor action selection in Parkinson's disease.
abstract: The effects of Parkinson's disease (PD) on the dynamics of impulsive action selection and suppression have recently been studied using distributional analyses, but with mixed results, especially for selection. Furthermore, some authors have suggested that impulsivity, regarded as a personality trait, shares common features with behavioral tasks' measures. The current study was designed to clarify the impact of PD on impulsive action selection and suppression, and investigate the link between cognitive action control and self-reported impulsivity. We administered an oculomotor version of the Simon task to 32 patients with PD and 32 matched healthy controls (HC), and conducted distributional analyses in accordance with the activation-suppression model. Patients and HC also filled out the Barratt Impulsiveness Scale (BIS) questionnaire. Results showed that patients with PD were faster overall and exhibited a greater congruence effect than HC. They also displayed enhanced impulsive action selection. By contrast, the suppression of impulsive responses was similar across both groups. Furthermore, patients had higher impulsivity scores, which were correlated with higher impulsive action selection and higher suppression. Our study yielded two interesting findings. First, PD resulted in a higher number of fast errors. The activation-suppression model suggests that patients with PD are more susceptible to the impulsive action selection induced by the irrelevant stimulus dimension. Second, impulsive action selection and suppression were both associated with trait impulsivity, as measured by the BIS, indicating that these two aspects of impulsivity share common features.
authors.affiliation: "Behavior and Basal Ganglia" research unit (EA 4712), University of Rennes 1, Avenue du Professeur Léon Bernard, 35000 Rennes, France. Electronic address: duprez.joan@gmail.com.
authors.forename: Joan
authors.initials: J
authors.lastname: Duprez
authors.affiliation: "Behavior and Basal Ganglia" research unit (EA 4712), University of Rennes 1, Avenue du Professeur Léon Bernard, 35000 Rennes, France; Department of Neurology, Rennes University Hospital, Rue Henri Le Guilloux, 35033 Rennes, France.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Houvenaghel
authors.affiliation: "Behavior and Basal Ganglia" research unit (EA 4712), University of Rennes 1, Avenue du Professeur Léon Bernard, 35000 Rennes, France; "Neuroscience of Emotion and Affective Dynamics" Lab, Swiss Center for Affective Sciences, 40 boulevard du Pont d'Arve, 1205 Geneva, Switzerland.
authors.forename: Soizic
authors.initials: S
authors.lastname: Argaud
authors.affiliation: "Behavior and Basal Ganglia" research unit (EA 4712), University of Rennes 1, Avenue du Professeur Léon Bernard, 35000 Rennes, France; Department of Psychiatry, Rennes University Hospital, 108 Avenue du Général Leclerc, 35703 Rennes, France; Clinical Investigation Center (INSERM 0203), Department of Pharmacology, Rennes University Hospital, Rue Henri Le Guilloux, 35033 Rennes, France.
authors.forename: Florian
authors.initials: F
authors.lastname: Naudet
authors.affiliation: "Behavior and Basal Ganglia" research unit (EA 4712), University of Rennes 1, Avenue du Professeur Léon Bernard, 35000 Rennes, France; Department of Psychiatry, Rennes University Hospital, 108 Avenue du Général Leclerc, 35703 Rennes, France.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Robert
authors.affiliation: "Behavior and Basal Ganglia" research unit (EA 4712), University of Rennes 1, Avenue du Professeur Léon Bernard, 35000 Rennes, France; Department of Psychiatry, Rennes University Hospital, 108 Avenue du Général Leclerc, 35703 Rennes, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Drapier
authors.affiliation: "Behavior and Basal Ganglia" research unit (EA 4712), University of Rennes 1, Avenue du Professeur Léon Bernard, 35000 Rennes, France; Department of Neurology, Rennes University Hospital, Rue Henri Le Guilloux, 35033 Rennes, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Vérin
authors.affiliation: "Behavior and Basal Ganglia" research unit (EA 4712), University of Rennes 1, Avenue du Professeur Léon Bernard, 35000 Rennes, France; Department of Neurophysiology, Rennes University Hospital, Rue Henri Le Guilloux, 35033 Rennes, France.
authors.forename: Paul
authors.initials: P
authors.lastname: Sauleau
mesh_terms: D003071:Cognition; D056344:Executive Function; D053483:Eye Movement Measurements; D005133:Eye Movements; D005260:Female; D006801:Humans; D007175:Impulsive Behavior; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000503:physiopathology / Q000523:psychology*; D011569:Psychiatric Status Rating Scales; D011930:Reaction Time; D011795:Surveys and Questionnaires
keywords: Activation-suppression; Cognitive action control; Impulsivity; Parkinson's disease; Simon task