title: Merosesquiterpene Congeners from the Australian Sponge Hyrtios digitatus as Potential Drug Leads for Atherosclerosis Disease.
abstract: A study of the chemical constituents from the Australian SpongeHyrtios digitatushas provided a perspective on the connection between the chemistry and biology of the puupehenones, a unique and unusual class of merosesquiterpenes. In this study, a new tetracyclic merosesquiterpene, 19-methoxy-9,15-ene-puupehenol (1) was isolated from the marine spongeHyrtios digitatusalong with the known 20-methoxy-9,15-ene-puupehenol (2). Their structures were elucidated on the basis of spectroscopic data (¹H and13C NMR) in combination with experimental electronic circular dichroism (ECD) data. Compounds1and2are active at 1.78 μM and 3.05 μM, respectively, on Scavenger Receptor-Class B Type 1 HepG2 (SR-B1 HepG2) stable cell lines, targeting atherosclerosis disease.
authors.affiliation: Eskitis Institute for Drug Discovery, Griffith University, Brisbane 4111, Australia. nuruhuda.abdulwahab@griffithuni.edu.au.|School of Fundamental Science, Universiti Malaysia Terengganu, Kuala Terengganu 21030, Malaysia. nuruhuda.abdulwahab@griffithuni.edu.au.
authors.forename: Huda A
authors.initials: HA
authors.lastname: Wahab
authors.affiliation: Eskitis Institute for Drug Discovery, Griffith University, Brisbane 4111, Australia. nhuda@umt.edu.my.
authors.forename: Ngoc B
authors.initials: NB
authors.lastname: Pham
authors.affiliation: School of Fundamental Science, Universiti Malaysia Terengganu, Kuala Terengganu 21030, Malaysia. sifzizul@umt.edu.my.|Institute of Marine Biotechnology, Universiti Malaysia Terengganu, Kuala Terengganu 21030, Malaysia. sifzizul@umt.edu.my.
authors.forename: Tengku S Tengku
authors.initials: TS
authors.lastname: Muhammad
authors.affiliation: Eskitis Institute for Drug Discovery, Griffith University, Brisbane 4111, Australia. n.pham@griffith.edu.au.|Queensland Museum, Brisbane 4101, Australia. n.pham@griffith.edu.au.
authors.forename: John N A
authors.initials: JN
authors.lastname: Hooper
authors.affiliation: Eskitis Institute for Drug Discovery, Griffith University, Brisbane 4111, Australia. r.quinn@griffith.edu.au.
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Quinn
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000188:drug therapy*; D001315:Australia; D002317:Cardiovascular Agents / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D056945:Hep G2 Cells; D006801:Humans; D011161:Porifera / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry* / Q000494:pharmacology*; D044004:Xanthones / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D002317:Cardiovascular Agents; D012717:Sesquiterpenes; D044004:Xanthones; C053594:puupehenone
keywords: HepG2; Hyrtios digitatus; SR-B1; atherosclerosis; merosesquiterpene