title: [c-MET Oncogene in Renal Cell Carcinomas].
abstract: c-Met plays a significant role in multiple cellular processes. Being encoded by a proto-oncogene, tyrosine kinase supports aggressive tumour behaviour such as tumour invasiveness and formation of metastases. For some subtypes of renal cell carcinoma studies have shown a association between c-Met expression and clinical outcome or prognosis. Therefore, c-Met represents a prognostic marker in renal cell carcinoma.Furthermore, c-MET will play a decisive role as a possible target for targeted therapies in the era of personalised medicine. Especially for RCC, the dual inhibition of VEGF and c-MET tyrosine kinase in cases of metastatic, treatment-resistant tumours is gaining clinical relevance. The role of c-Met has not been fully elucidated for all subtypes of renal cell carcinomas. The relevance of c-Met for the remaining subtypes of renal tumours has yet to be clarified.
authors.affiliation: Institut für Pathologie, Technische Universität München.
authors.forename: F
authors.initials: F
authors.lastname: Erlmeier
authors.affiliation: Institut für Pathologie, Technische Universität München.
authors.forename: W
authors.initials: W
authors.lastname: Weichert
authors.affiliation: Klinik und Poliklinik für Urologie, Klinikum rechts der Isar, Technische Universität München.
authors.forename: M
authors.initials: M
authors.lastname: Autenrieth
authors.affiliation: Klinik für Hämatologie, Hämostaseologie, Onkologie und Stammzelltransplantation, Medizinische Hochschule Hannover.
authors.forename: P
authors.initials: P
authors.lastname: Ivanyi
authors.affiliation: Mitglied des Deutschen Netzwerks Nierenzelltumoren.
authors.forename: A
authors.initials: A
authors.lastname: Hartmann
authors.affiliation: Mitglied des Deutschen Netzwerks Nierenzelltumoren.
authors.forename: S
authors.initials: S
authors.lastname: Steffens
mesh_terms: D002291:Carcinoma, Papillary / Q000235:genetics / Q000401:mortality / Q000473:pathology; D002292:Carcinoma, Renal Cell / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D004252:DNA Mutational Analysis; D006801:Humans; D007668:Kidney / Q000473:pathology; D007680:Kidney Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D009361:Neoplasm Invasiveness / Q000235:genetics; D011379:Prognosis; D000090063:Proto-Oncogene Mas; D019859:Proto-Oncogene Proteins c-met / Q000235:genetics*; D015996:Survival Rate
chemical_list: C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D019859:Proto-Oncogene Proteins c-met