title: Exosomal communication in glioma - a review.
abstract: Cancer research has revealed the existence of cancer stem cells (CSCs). However, the influence of the surrounding stromal cells present in the microenvironment on CSCs is still poorly understood. The latest studies on gliomas suggested that the microenvironment of human gliomas contains both glioma stem cells (GSCs) and glioma associated (GA)-mesenchymal stem cells (MSCs; (GA-MSCs). Also, studies have suggested that nano- sized vesicles, termed exosomes, have been recently observed to contribute towards intercellular communication within the tumor niche. The present review article will highlight the current view of exosomal communication in gliomas.
authors.affiliation: Department of Neurosurgery, Central Hospital of Xuzhou, the Affiliated Hospital of Southeast University, Xuzhou, Jiangsu, China.
authors.forename: Hongsheng
authors.initials: H
authors.lastname: Xu
authors.forename: Kezhong
authors.initials: K
authors.lastname: Zhang
authors.forename: Hailiang
authors.initials: H
authors.lastname: Zong
authors.forename: Ming
authors.initials: M
authors.lastname: Shang
authors.forename: Kai
authors.initials: K
authors.lastname: Li
authors.forename: Xiaoguang
authors.initials: X
authors.lastname: He
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000378:metabolism* / Q000473:pathology; D055354:Exosomes / Q000378:metabolism* / Q000473:pathology; D005910:Glioma / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000378:metabolism / Q000473:pathology; D014411:Neoplastic Stem Cells / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction; D055153:Stem Cell Niche; D059016:Tumor Microenvironment