title: Risk for Health Care-Associated Bloodstream Infections in Pediatric Oncology Patients With Various Malignancies.
abstract: This was a retrospective cohort study to identify the rates, predictors, and outcomes of health care-associated bloodstream infections (HA-BSI) among children with solid tumors, lymphoma, lymphoid leukemia, and myeloid leukemia. The study population included 4500 children ≤18 years old at a pediatric hospital in New York City from 2006 to 2014. A total of 147 HA-BSI cases were identified; using multivariable logistic regression modeling, children with a hematologic diagnosis (lymphoma, lymphoid leukemia, myeloid leukemia) were at greater risk for HA-BSI than those with a solid tumor diagnosis (all P values <.0001). The odds of mortality for patients with HA-BSI were 6.98 (95% confidence interval 3.02-16.10) times that of those without HA-BSI. Although malignancy type was identified as risk factor for HA-BSI, there was no significant difference in overall mortality from HA-BSI by tumor type ( P = .51).
authors.affiliation: 1 Columbia University, New York, NY, USA.
authors.forename: Cara B
authors.initials: CB
authors.lastname: Thurman
authors.affiliation: 1 Columbia University, New York, NY, USA.
authors.forename: Maura
authors.initials: M
authors.lastname: Abbott
authors.affiliation: 1 Columbia University, New York, NY, USA.
authors.forename: Jinfang
authors.initials: J
authors.lastname: Liu
authors.affiliation: 1 Columbia University, New York, NY, USA.
authors.forename: Elaine
authors.initials: E
authors.lastname: Larson
mesh_terms: D016470:Bacteremia / Q000453:epidemiology* / Q000209:etiology; D055499:Catheter-Related Infections / Q000453:epidemiology* / Q000209:etiology; D002405:Catheterization, Central Venous / Q000009:adverse effects* / Q000706:statistics & numerical data; D002648:Child; D015331:Cohort Studies; D003428:Cross Infection / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D006776:Hospitals, Pediatric; D006801:Humans; D016015:Logistic Models; D008297:Male; D009369:Neoplasms / Q000150:complications; D012189:Retrospective Studies; D012307:Risk Factors
keywords: epidemiology; health care–associated infections; hematology; oncology