title: The paired receptors TIGIT and DNAM-1 as targets for therapeutic antibodies.
abstract: One of the most exciting fields in modern medicine is immunotherapy, treatment which looks to harness the power of the immune system to fight disease. A particularly effective strategy uses antibodies designed to influence the activity levels of the immune system. Here we look at two receptors - TIGIT and DNAM-1 - which bind the same ligands but have opposite effects on immune cells, earning them the label `paired receptors'. Importantly, natural killer cells and cytotoxic T cells express both of these receptors, and in certain cases their effector functions are dictated by TIGIT or DNAM-1 signaling. Agonist and antagonist antibodies targeting either TIGIT or DNAM-1 present many therapeutic options for diseases spanning from cancer to auto-immunity. In this review we present cases in which the modulation of these receptors holds potential for the development of novel therapies.
authors.forename: Natan
authors.initials: N
authors.lastname: Stein
authors.forename: Pinchas
authors.initials: P
authors.lastname: Tsukerman
authors.forename: Ofer
authors.initials: O
authors.lastname: Mandelboim
mesh_terms: D000945:Antigens, Differentiation, T-Lymphocyte / Q000235:genetics / Q000276:immunology*; D000074322:Antineoplastic Agents, Immunological / Q000627:therapeutic use*; D001327:Autoimmune Diseases / Q000188:drug therapy* / Q000235:genetics / Q000276:immunology / Q000473:pathology; D005786:Gene Expression Regulation; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000276:immunology / Q000473:pathology; D011485:Protein Binding; D020239:Receptor Cross-Talk / Q000276:immunology; D011971:Receptors, Immunologic / Q000819:agonists / Q000037:antagonists & inhibitors / Q000235:genetics / Q000276:immunology*; D015398:Signal Transduction; D013602:T-Lymphocytes, Cytotoxic / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D000098862:T Lineage-Specific Activation Antigen 1
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte; D000074322:Antineoplastic Agents, Immunological; D000098862:T Lineage-Specific Activation Antigen 1; D011971:Receptors, Immunologic; C534712:TIGIT protein, human
keywords: DNAM-1; NK cells; TIGIT; autoimmune disease; cancer; immunotherapy