title: Myeloid-Derived Suppressor Cells Are Controlled by Regulatory T Cells via TGF-β during Murine Colitis.
abstract: Myeloid-derived suppressor cells (MDSCs) are well known regulators of regulatory T cells (Treg cells); however, the direct regulation of MDSCs by Treg cells has not been well characterized. We find that colitis caused by functional deficiency of Treg cells leads to altered expansion and reduced function of MDSCs. During differentiation of MDSCs in vitro from bone marrow cells, Treg cells enhanced MDSC function and controlled their differentiation through a mechanism involving transforming growth factor-β (TGF-β). TGF-β-deficient Treg cells were not able to regulate MDSC function in an experimentally induced model of colitis. Finally, we evaluated the therapeutic effect of TGF-β-mediated in-vitro-differentiated MDSCs on colitis. Adoptive transfer of MDSCs that differentiated with TGF-β led to better colitis prevention than the transfer of MDSCs that differentiated without TGF-β. Our results demonstrate an interaction between Treg cells and MDSCs that contributes to the regulation of MDSC proliferation and the acquisition of immunosuppressive functions.
authors.affiliation: School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea.
authors.forename: Cho-Rong
authors.initials: CR
authors.lastname: Lee
authors.affiliation: School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea.
authors.forename: Yewon
authors.initials: Y
authors.lastname: Kwak
authors.affiliation: School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea.
authors.forename: Taewoo
authors.initials: T
authors.lastname: Yang
authors.affiliation: Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea.
authors.forename: Jung Hyun
authors.initials: JH
authors.lastname: Han
authors.affiliation: School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea.
authors.forename: Sang-Heon
authors.initials: SH
authors.lastname: Park
authors.affiliation: School of Liberal Arts and Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea.
authors.forename: Michael B
authors.initials: MB
authors.lastname: Ye
authors.affiliation: School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea.
authors.forename: Wongeun
authors.initials: W
authors.lastname: Lee
authors.affiliation: School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea.
authors.forename: Kyu-Young
authors.initials: KY
authors.lastname: Sim
authors.affiliation: School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea.
authors.forename: Jung-Ah
authors.initials: JA
authors.lastname: Kang
authors.affiliation: School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea; Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea.
authors.forename: Yong-Chul
authors.initials: YC
authors.lastname: Kim
authors.affiliation: Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
authors.forename: Sarkis K
authors.initials: SK
authors.lastname: Mazmanian
authors.affiliation: School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea; Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea. Electronic address: sgpark@gist.ac.kr.
authors.forename: Sung-Gyoo
authors.initials: SG
authors.lastname: Park
mesh_terms: D019264:Adoptive Transfer; D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology; D002454:Cell Differentiation / Q000235:genetics; D049109:Cell Proliferation / Q000235:genetics; D003092:Colitis / Q000139:chemically induced / Q000235:genetics* / Q000378:metabolism; D016264:Dextran Sulfate / Q000633:toxicity; D006801:Humans; D007249:Inflammation / Q000235:genetics* / Q000378:metabolism; D051379:Mice; D000072737:Myeloid-Derived Suppressor Cells / Q000166:cytology* / Q000378:metabolism; D050378:T-Lymphocytes, Regulatory / Q000166:cytology* / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000235:genetics* / Q000378:metabolism
chemical_list: D016212:Transforming Growth Factor beta; D016264:Dextran Sulfate
keywords: MDSC; TGF-β; Treg cell; colitis; inflammation