title: Further intracellular proteins and signaling pathways regulated by angiotensin-(1-7) in human endothelial cells.
abstract: In 2016, Meinert et al. (doi: 10.1016/j.jprot.2015.09.020) published the first 25 proteins in a protein array regulated in Human Umbilical Vein Endothelial Cells (HUVEC) by the heptapeptide angiotensin (Ang)-(1-7) and the first 10 intracellular signaling cascades at different time points. This supporting data article shows further proteins and pathways stimulated by Ang-(1-7) in human endothelial cells at time points of 1 h, 3 h, 6 h, and 9 h. HUVECs were stimulated with Ang-(1-7), and regulated proteins were identified via antibody microarray. Bioinformatics software IPA was used for association of regulated proteins to metabolic pathways.
authors.affiliation: Institute of Experimental and Clinical Pharmacology and Toxicology, Medical Faculty Mannheim, Universität Heidelberg, Mannheim, Germany; Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland.
authors.forename: Christian
authors.initials: C
authors.lastname: Meinert
authors.affiliation: Departments of Obstetrics and Pediatric Surgery, Division of Women and Child Health, Universität Leipzig, Leipzig, Germany.
authors.forename: Franziska
authors.initials: F
authors.lastname: Kohse
authors.affiliation: Departments of Obstetrics and Pediatric Surgery, Division of Women and Child Health, Universität Leipzig, Leipzig, Germany.
authors.forename: Ilka
authors.initials: I
authors.lastname: Böhme
authors.affiliation: Division of Nephrology, Department of Internal Medicine III, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
authors.forename: Florian
authors.initials: F
authors.lastname: Gembardt
authors.affiliation: Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland; Departments of Obstetrics and Pediatric Surgery, Division of Women and Child Health, Universität Leipzig, Leipzig, Germany.
authors.forename: Anja
authors.initials: A
authors.lastname: Tetzner
authors.affiliation: Institute of Experimental and Clinical Pharmacology and Toxicology, Medical Faculty Mannheim, Universität Heidelberg, Mannheim, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Wieland
authors.affiliation: Division of Cardiology, University of California, San Diego, USA.
authors.forename: Barry
authors.initials: B
authors.lastname: Greenberg
authors.affiliation: Institute of Experimental and Clinical Pharmacology and Toxicology, Medical Faculty Mannheim, Universität Heidelberg, Mannheim, Germany; Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland; Departments of Obstetrics and Pediatric Surgery, Division of Women and Child Health, Universität Leipzig, Leipzig, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Walther
keywords: Angiotensin-(1-7); Antibody microarray; Cell signaling; Endothelium; Renin-Angiotensin system