title: Lignan derivatives from Selaginella tamariscina and their nitric oxide inhibitory effects in LPS-stimulated RAW 264.7 cells.
abstract: The chemical characterization of Selaginella tamariscina leaves resulted in the isolation of five lignanoside derivatives (1-4 and 6) and one neolignan (5). These compounds include three new lignanosides, tamariscinosides D-F (1-3), and one liriodendrin (4) that were isolated for the first time from this plant, together with two known compounds, (2R,3S)-dihydro-2-(3,5-dimethoxy-4-hydroxyphenyl)-7-methoxy-5-acetyl-benzofuran (5) and moellenoside B (6). The chemical structures of these isolated compounds were determined using 1D and 2D NMR, MS, and CD spectroscopic data, and the results were compared to data previously reported in the literatures. These compounds were also evaluated in terms of their inhibition of NO production in lipopolysaccharide (LPS)-stimulated activity in the macrophage cell line RAW 264.7. Among them, compounds 1, 2, 5, and 6 exhibited a significant inhibition with IC50values ranging from 32.3 to 55.8μM.
authors.affiliation: College of Pharmacy, Catholic University of Daegu, Gyeongsan 38430, Republic of Korea.
authors.forename: Le Duc
authors.initials: LD
authors.lastname: Dat
authors.affiliation: College of Pharmacy, Catholic University of Daegu, Gyeongsan 38430, Republic of Korea.
authors.forename: Bing Tian
authors.initials: BT
authors.lastname: Zhao
authors.affiliation: College of Pharmacy, Catholic University of Daegu, Gyeongsan 38430, Republic of Korea; Phutho College of Pharmacy, Viettri City, Phutho Province 290000, Viet Nam.
authors.forename: Nguyen Duc
authors.initials: ND
authors.lastname: Hung
authors.affiliation: College of Natural Science, Kangwon National University, Kangwon 200-701, Republic of Korea.
authors.forename: Jeong Hyung
authors.initials: JH
authors.lastname: Lee
authors.affiliation: College of Pharmacy, Catholic University of Daegu, Gyeongsan 38430, Republic of Korea.
authors.forename: Byung Sun
authors.initials: BS
authors.lastname: Min
authors.affiliation: College of Pharmacy, Catholic University of Daegu, Gyeongsan 38430, Republic of Korea. Electronic address: woomh@cu.ac.kr.
authors.forename: Mi Hee
authors.initials: MH
authors.lastname: Woo
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D000067996:RAW 264.7 Cells; D032503:Selaginellaceae / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D017705:Lignans; D008070:Lipopolysaccharides; D009569:Nitric Oxide
keywords: F; Lignan; NO production inhibition; Selaginella tamariscina; Tamariscinosides D