title: Association between markers of bone loss and urinary lithogenic risk factors in osteopenic postmenopausal women.
abstract: In this study, we explored if urinary lithogenic risk parameters could have some application for monitoring bone health status. We recruited 20 women with postmenopausal osteopenia and a negative medical history for nephrolithiasis. Markers of lithogenic risk were evaluated on 24-h urine and fastingmorning urine. Serum levels of bone turnover markers (BTM) were measured in fasting-blood samples. We found that cross-linked telopeptide of type I collagen (CTX) was significantly correlated with 24-h calcium excretion. N-terminal propeptide of type I procollagen (PINP) correlated with 24-h excretion of potassium, calcium and citrate. CTX had considerably increased in patients with pH less than 5.5. Low citrate levels (less than 3.3 mmol/24 h) were associated with lower levels of CTX and PINP. Our findings suggest that a low-grade acidosis and some lithogenic risk factors are detectable in a proportion of patients with postmenopausal osteopenia. Further studies are necessary to confirm that this evaluation could be clinically relevant.
authors.affiliation: Orthopedic Pathophysiology and Regenerative Medicine Unit, Rizzoli Orthopedic Institute, Bologna, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Granchi
authors.affiliation: Villalba Hospital, GVM Care and Research, Bologna, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Caudarella
authors.affiliation: Osteoporosis and Metabolic Bone Disease Unit, Rizzoli Orthopedic Institute, Bologna, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Ripamonti
authors.affiliation: Diagnostic and Interventional Radiology, Rizzoli Orthopedic Institute, Bologna, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Spinnato
authors.affiliation: Diagnostic and Interventional Radiology, Rizzoli Orthopedic Institute, Bologna, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Bazzocchi
authors.affiliation: Orthopedic Pathophysiology and Regenerative Medicine Unit, Rizzoli Orthopedic Institute, Bologna, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Torreggiani
authors.affiliation: Orthopedic Pathophysiology and Regenerative Medicine Unit, Rizzoli Orthopedic Institute, Bologna, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Massa
authors.affiliation: Orthopedic Pathophysiology and Regenerative Medicine Unit, Rizzoli Orthopedic Institute, Bologna, Italy.|Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy
authors.forename: N
authors.initials: N
authors.lastname: Baldini
mesh_terms: D015415:Biomarkers / Q000378:metabolism*; D015519:Bone Density; D016723:Bone Remodeling; D024042:Collagen Type I / Q000378:metabolism*; D005260:Female; D006801:Humans; D015663:Osteoporosis, Postmenopausal / Q000378:metabolism*; D010446:Peptide Fragments / Q000378:metabolism; D010455:Peptides; D017698:Postmenopause / Q000378:metabolism; D011347:Procollagen / Q000378:metabolism; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D024042:Collagen Type I; D010446:Peptide Fragments; D010455:Peptides; D011347:Procollagen