title: Surviving Naegleria fowleri infections: A successful case report and novel therapeutic approach.
abstract: Naegleria fowleri is a deadly human pathogen recognized as the causative agent of Primary Amoebic Meningitis (PAM). N. fowleri is commonly found in warm freshwater environments such as natural or man-made lakes, hot springs, and resort spas frequented by tourists. PAM infections have a mortality rate between 95 and 99% with minimal progress being made toward a successful treatment therapy. We report the case of a 12-year old American female who survived a PAM infection and propose a new drug therapy which includes the antimicrobial drug Miltefosine.
authors.affiliation: Bowling Green State University, School of Human Movement, Sport and Leisure Studies, Bowling Green, OH 43403, USA; School of Public Health, Tropical Medicine and Rehabilitation Sciences, James Cook University, Townsville, Qld, Australia. Electronic address: theggie@bgsu.edu.
authors.forename: Travis W
authors.initials: TW
authors.lastname: Heggie
authors.affiliation: Institute of Occupational and Social Medicine, RWTH Aachen Technical University, Pauwelsstr. 30, D-52074 Aachen, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Küpper
mesh_terms: D000981:Antiprotozoal Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001929:Brain Edema; D020808:Central Nervous System Protozoal Infections / Q000175:diagnosis / Q000469:parasitology / Q000628:therapy; D002648:Child; D005260:Female; D006801:Humans; D007036:Hypothermia, Induced; D016848:Naegleria fowleri; D010767:Phosphorylcholine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use
chemical_list: D000981:Antiprotozoal Agents; D010767:Phosphorylcholine; C039128:miltefosine
keywords: Miltefosine; Naegleria fowleri; Primary Amoebic Meningitis