title: Stereotactic radiosurgery for intradural spine tumors using cone-beam CT image guidance.
abstract: OBJECTIVE Cone-beam CT (CBCT) image guidance technology has been widely adopted for spine radiosurgery delivery. There is relatively little experience with spine radiosurgery for intradural tumors using CBCT image guidance. This study prospectively evaluated a series of intradural spine tumors treated with radiosurgery. Patient setup accuracy for spine radiosurgery delivery using CBCT image guidance for intradural spine tumors was determined. METHODS Eighty-two patients with intradural tumors were treated and prospectively evaluated. The positioning deviations of the spine radiosurgery treatments in patients were recorded. Radiosurgery was delivered using a linear accelerator with a beam modulator and CBCT image guidance combined with a robotic couch that allows positioning correction in 3 translational and 3 rotational directions. To measure patient movement, 3 quality assurance CBCTs were performed and recorded in 30 patients: before, halfway, and after the radiosurgery treatment. The positioning data and fused images of planning CT and CBCT from the treatments were analyzed to determine intrafraction patient movements. From each of 3 CBCTs, 3 translational and 3 rotational coordinates were obtained. RESULTS The radiosurgery procedure was successfully completed for all patients. Lesion locations included cervical (22), thoracic (17), lumbar (38), and sacral (5). Tumor histologies included schwannoma (27), neurofibromas (18), meningioma (16), hemangioblastoma (8), and ependymoma (5). The mean prescription dose was 17 Gy (range 12-27 Gy) delivered in 1-3 fractions. At the halfway point of the radiation, the translational variations and standard deviations were 0.4 ± 0.5, 0.5 ± 0.8, and 0.4 ± 0.5 mm in the lateral (x), longitudinal (y), and anteroposterior (z) directions, respectively. Similarly, the variations immediately after treatment were 0.5 ± 0.4, 0.5 ± 0.6, and 0.6 ± 0.5 mm along x, y, and z directions, respectively. The mean rotational angles were 0.3° ± 0.4°, 0.3° ± 0.4°, and 0.3° ± 0.4° along yaw, roll, and pitch, respectively, at the halfway point and 0.5° ± 0.5°, 0.4° ± 0.5°, and 0.2° ± 0.3° immediately after treatment. CONCLUSIONS Radiosurgery offers an alternative treatment option for intradural spine tumors in patients who may not be optimal candidates for open surgery. CBCT image guidance for patient setup for spine radiosurgery is accurate and successful in patients with intradural tumors.
authors.affiliation: Departments of 1 Neurological Surgery and.
authors.forename: Andrés
authors.initials: A
authors.lastname: Monserrate
authors.affiliation: Departments of 1 Neurological Surgery and.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Zussman
authors.affiliation: Departments of 1 Neurological Surgery and.
authors.forename: Alp
authors.initials: A
authors.lastname: Ozpinar
authors.affiliation: Departments of 1 Neurological Surgery and.
authors.forename: Ajay
authors.initials: A
authors.lastname: Niranjan
authors.affiliation: Radiation Oncology, University of Pittsburgh Medical Center; and.|Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania.
authors.forename: John C
authors.initials: JC
authors.lastname: Flickinger
authors.affiliation: Departments of 1 Neurological Surgery and.|Radiation Oncology, University of Pittsburgh Medical Center; and.
authors.forename: Peter C
authors.initials: PC
authors.lastname: Gerszten
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D054893:Cone-Beam Computed Tomography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016634:Radiosurgery / Q000379:methods*; D013120:Spinal Cord Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery*; D013125:Spinal Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery*; D016896:Treatment Outcome; D055815:Young Adult
keywords: CBCT = cone-beam CT; IMRT = intensity-modulated radiotherapy; QA = quality assurance; cone-beam CT; intradural tumors; spine radiosurgery; spine tumors