title: Multifunctional Self-Adhesive Fibrous Layered Matrix (FiLM) for Tissue Glues and Therapeutic Carriers.
abstract: Tissue adhesives, which inherently serve as wound sealants or as hemostatic agents, can be further augmented to acquire crucial functions as scaffolds, thereby accelerating wound healing or elevating the efficacy of tissue regeneration. Herein, multifunctional adherent fibrous matrices, acting as self-adhesive scaffolds capable of cell/gene delivery, were devised by coaxially electrospinning poly(caprolactone) (PCL) and poly(vinylpyrrolidone) (PVP). Wrapping the building block PCL fibers with the adherent PVP layers formed film-like fibrous matrices that could rapidly adhere to wet biological surfaces, referred to as fibrous layered matrix (FiLM) adhesives. The inclusion of ionic salts (i.e., dopamine hydrochloride) in the sheath layers generated spontaneously multilayered fibrous adhesives, whose partial layers could be manually peeled off, termed derivative FiLM (d-FiLM). In the context of scaffolds/tissue adhesives, both FiLM and d-FiLM demonstrated almost identical characteristics (i.e., sticky, mechanical, and performances as cell/gene carriers). Importantly, the single FiLM-process can yield multiple sets of d-FiLM by investing the same processing time, materials, and labor required to form a single conventional adhesive fibrous mat, thereby highlighting the economic aspects of the process. The FiLM/d-FiLM offer highly impacting contributions to many biomedical applications, especially in fields that require urgent aids (e.g., endoscopic surgeries, implantation in wet environments, severe wounds).
authors.affiliation: Department of Chemical and Biomolecular Engineering, Yonsei University , 50, Yonsei-ro, Seodaemun-gu, Seoul, 120-749, Korea.
authors.forename: Ye-Eun
authors.initials: YE
authors.lastname: Yoon
authors.affiliation: Department of Chemical and Biomolecular Engineering, Yonsei University , 50, Yonsei-ro, Seodaemun-gu, Seoul, 120-749, Korea.
authors.forename: Byung Gee
authors.initials: BG
authors.lastname: Im
authors.affiliation: Department of Chemical and Biomolecular Engineering, Yonsei University , 50, Yonsei-ro, Seodaemun-gu, Seoul, 120-749, Korea.
authors.forename: Jung-Suk
authors.initials: JS
authors.lastname: Kim
authors.affiliation: Department of Chemical and Biomolecular Engineering, Yonsei University , 50, Yonsei-ro, Seodaemun-gu, Seoul, 120-749, Korea.
authors.forename: Jae-Hyung
authors.identifier: 0000-0001-6321-4688
authors.initials: JH
authors.lastname: Jang
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D002470:Cell Survival / Q000187:drug effects; D000229:Dependovirus / Q000235:genetics; D016503:Drug Delivery Systems; D005260:Female; D005822:Genetic Vectors / Q000008:administration & dosage; D049452:Green Fluorescent Proteins / Q000235:genetics; D057809:HEK293 Cells; D006801:Humans; D019169:Jurkat Cells; D008422:Materials Testing; D051379:Mice; D008813:Mice, Inbred ICR; D041681:NIH 3T3 Cells; D011091:Polyesters / Q000737:chemistry*; D016062:Porosity; D014014:Tissue Adhesives / Q000737:chemistry*; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry*; D014945:Wound Healing
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; D014014:Tissue Adhesives; D049452:Green Fluorescent Proteins