title: Heat Shock Proteins and Cancer.
abstract: Heat shock proteins (HSPs) constitute a large family of proteins involved in protein folding and maturation whose expression is induced by heat shock or other stressors. The major groups are classified based on their molecular weights and include HSP27, HSP40, HSP60, HSP70, HSP90, and large HSPs. HSPs play a significant role in cellular proliferation, differentiation, and carcinogenesis. In this article we comprehensively review the roles of major HSPs in cancer biology and pharmacology. HSPs are thought to play significant roles in the molecular mechanisms leading to cancer development and metastasis. HSPs may also have potential clinical uses as biomarkers for cancer diagnosis, for assessing disease progression, or as therapeutic targets for cancer therapy.
authors.affiliation: Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, China.
authors.forename: Jianming
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Biomedical Sciences, West Virginia School of Osteopathic Medicine, Lewisburg, WV 24901, USA. Electronic address: tliu@osteo.wvsom.edu.
authors.forename: Tuoen
authors.initials: T
authors.lastname: Liu
authors.affiliation: University of Illinois College of Medicine at Chicago, Chicago, IL 60612, USA.
authors.forename: Zechary
authors.initials: Z
authors.lastname: Rios
authors.affiliation: Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, China.
authors.forename: Qibing
authors.initials: Q
authors.lastname: Mei
authors.affiliation: Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, China.
authors.forename: Xiukun
authors.initials: X
authors.lastname: Lin
authors.affiliation: Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, China. Electronic address: shousongc@gmail.com.
authors.forename: Shousong
authors.initials: S
authors.lastname: Cao
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D006360:Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000378:metabolism* / Q000628:therapy
chemical_list: D006360:Heat-Shock Proteins
keywords: biomarker; cancer; carcinogenesis; heat shock protein; therapeutic target