title: Test-retest reliability and concurrent validity of in vivo myelin content indices: Myelin water fraction and calibrated T1w/T2w image ratio.
abstract: In an age-heterogeneous sample of healthy adults, we examined test-retest reliability (with and without participant repositioning) of two popular MRI methods of estimating myelin content: modeling the short spin-spin (T2) relaxation component of multi-echo imaging data and computing the ratio of T1-weighted and T2-weighted images (T1w/T2w). Taking the myelin water fraction (MWF) index of myelin content derived from the multi-component T2relaxation data as a standard, we evaluate the concurrent and differential validity of T1w/T2w ratio images. The results revealed high reliability of MWF and T1w/T2w ratio. However, we found significant correlations of low to moderate magnitude between MWF and the T1w/T2w ratio in only two of six examined regions of the cerebral white matter. Notably, significant correlations of the same or greater magnitude were observed for T1w/T2w ratio and the intermediate T2relaxation time constant, which is believed to reflect differences in the mobility of water between the intracellular and extracellular compartments. We conclude that although both methods are highly reliable and thus well-suited for longitudinal studies, T1w/T2w ratio has low criterion validity and may be not an optimal index of subcortical myelin content. Hum Brain Mapp 38:1780-1790, 2017. © 2017 Wiley Periodicals, Inc.
authors.affiliation: Department of Psychiatry and Behavioral Neuroscience, School of Medicine, Wayne State University, Detroit, Michigan.|Institute of Gerontology, Wayne State University, Detroit, Michigan.
authors.forename: Muzamil
authors.initials: M
authors.lastname: Arshad
authors.affiliation: Department of Psychiatry and Behavioral Neuroscience, School of Medicine, Wayne State University, Detroit, Michigan.
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Stanley
authors.affiliation: Institute of Gerontology, Wayne State University, Detroit, Michigan.|Department of Psychology, Wayne State University, Detroit, Michigan.
authors.forename: Naftali
authors.initials: N
authors.lastname: Raz
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D001921:Brain / Q000033:anatomy & histology* / Q000000981:diagnostic imaging*; D016022:Case-Control Studies; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009186:Myelin Sheath / Q000378:metabolism*; D015203:Reproducibility of Results; D014867:Water / Q000378:metabolism*
chemical_list: D014867:Water
keywords: MRI; Simpson paradox; T2 relaxation; brain water mobility; white matter