title: Amphiphilic Cyclodextrin Derivatives for Targeted Drug Delivery to Tumors.
abstract: Villiers has extensively studied cyclodextrins, a family of macrocyclic oligosaccharides linked by α-1,4 glycosidic bonds, in different fields since their discovery in 1891. The unique structure enabling inclusion complexation for natural cyclodextrins and cyclodextrin derivatives make them attractive for novel drug delivery systems. Cyclodextrins can be modified with long aliphatic chains to render an amphiphilic property and these different amphiphilic cyclodextrins are able to form nanoparticles without surfactants. In the literature, several different amphiphilic cyclodextrins are reported and applied to drug delivery and targeting especially to tumors. Specificly, folateconjugated amphiphilic cyclodextrin derivatives are used for active tumor targeting of poorly water soluble drugs and improve the efficacy and safety of therapeutic agents. On the other hand, effect of positive surface charge has also been under research in the recent years. Polycationic amphiphilic cyclodextrins have shown promise towards forming small complexes with negatively charged molecules such as drugs or plasmid DNA. Polycationic amphiphilic cyclodextrins enhance interaction with cell membrane due to their net positive surface charge. The scope of this review is to describe potential uses and pharmaceutical applications of tumor-targeted amphiphilic cyclodextrins, with focus on folate-conjugated cyclodextrin derivatives and polycationic cyclodextrin derivatives both studied by our group at Hacettepe University.
authors.affiliation: Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, 06100 Sıhhiye-Ankara, Turkey.
authors.forename: Nazlı
authors.initials: N
authors.lastname: Erdogar
authors.affiliation: Department of Nanotechnology and Nanomedicine, Instıtute of Graduate Studies in Science, Hacettepe University, 06800 Beytepe-Ankara, Turkey.
authors.forename: Gamze
authors.initials: G
authors.lastname: Varan
authors.affiliation: Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, 06100 Sıhhiye- Ankara, Turkey.
authors.forename: Erem
authors.initials: E
authors.lastname: Bilensoy
mesh_terms: D003505:Cyclodextrins / Q000008:administration & dosage* / Q000737:chemistry; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry; D016503:Drug Delivery Systems; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D013501:Surface-Active Agents / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D003505:Cyclodextrins; D004337:Drug Carriers; D013501:Surface-Active Agents
keywords: Amphiphilic; Cyclodextrin; Drug delivery; Folate; Polycationic; Targeting