title: Regulation of CREB Functions by Phosphorylation and Sumoylation in Nervous and Visual Systems.
abstract: CREB is an ubiquitous transcription factor regulating diverse cellular responses. Its phosphorylation at S133 is an essential event for its activation in both nervous and visual systems. The activated CREB is implicated in the regulation of development, protection, learning, memory and plasticity in the nerve system. Moreover, sumoylation, an important post-translational modification of protein, plays a key role in sustaining CREB activation in the rat hippocampus in order to enhance the long-term memory and other aspects. In the visual system, although the CREB activation by phosphorylation at S133 is similar to that as observed in the nervous system, the role of CREB sumoylation remains to be explored. This review will discuss the aspects of CREB functions and their regulation by phosphorylation and sumoylation in both systems.
authors.forename: L
authors.initials: L
authors.lastname: Wang
authors.forename: X-H
authors.initials: XH
authors.lastname: Hu
authors.forename: Z-X
authors.initials: ZX
authors.lastname: Huang
authors.forename: Q
authors.initials: Q
authors.lastname: Nie
authors.forename: Z-G
authors.initials: ZG
authors.lastname: Chen
authors.forename: J-W
authors.initials: JW
authors.lastname: Xiang
authors.forename: R-L
authors.initials: RL
authors.lastname: Qi
authors.forename: T-H
authors.initials: TH
authors.lastname: Yang
authors.forename: Y
authors.initials: Y
authors.lastname: Xiao
authors.forename: W-J
authors.initials: WJ
authors.lastname: Qing
authors.forename: G
authors.initials: G
authors.lastname: Gigantelli
authors.forename: Q D
authors.initials: QD
authors.lastname: Nguyen
authors.affiliation: Department of Ophthalmology and Visual Sciences, Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, Nebraska 68198- 5540,. United States.
authors.forename: D W-C
authors.initials: DW
authors.lastname: Li
mesh_terms: D000818:Animals; D017362:Cyclic AMP Response Element-Binding Protein / Q000235:genetics*; D005786:Gene Expression Regulation; D006624:Hippocampus / Q000254:growth & development / Q000502:physiology; D006801:Humans; D008568:Memory / Q000502:physiology*; D009424:Nervous System Physiological Phenomena / Q000235:genetics; D010766:Phosphorylation / Q000235:genetics; D011499:Protein Processing, Post-Translational / Q000235:genetics; D051381:Rats; D015398:Signal Transduction / Q000235:genetics; D058207:Sumoylation / Q000235:genetics*; D014785:Vision, Ocular / Q000235:genetics* / Q000502:physiology
chemical_list: C115163:CREB1 protein, human; D017362:Cyclic AMP Response Element-Binding Protein
keywords: CREB; eye; lens; nervous system; phosphorylation; sumoylation; visual system