title: Comparative assessment of "plaque/media" change on three modalities of IVUS immediately after implantation of either everolimus-eluting bioresorbable vascular scaffold or everolimus-eluting metallic stent in Absorb II study.
abstract: The purpose of the study to assess the comparability of immediate changes in plaque/media volume (PV) on three modalities of intravascular ultrasound (IVUS) after implantation of either bioresorbable vascular scaffold (BVS) or everolimus-eluting metallic stent (EES) in Absorb II Study. The two devices have different device volume and ultrasound backscattering that may interfere with the "plaque/media" assessed by three modalities on IVUS: grayscale, backscattering of radiofrequency and brightness function. In a multicenter randomized controlled trial, 501 patients with stable or unstable angina underwent documentary IVUS pre- and post- implantation. The change in plaque/media volume (PV) was categorized into three groups according to the relative PV change in device segment: PV "increased" >+5% (PVI), PV unchanged ±5% (PVU), and PV decreased <-5% (PVD). The change in PV was re-evaluated three times: after subtraction of theoretical device volume, after analysis of echogenicity based on brightness function. In 449 patients, 483 lesions were analyzed pre- and post-implantation. "PVI" was more frequently observed in BVS (53.8%) than EES group (39.4%), p = 0.006. After subtraction of the theoretical device volume, the frequency of "PVI" decreased in both BVS (36.2%) and EES (32.1%) groups and became comparable (p = 0.581). In addition, the percentage of "PVI" was further reduced in both device groups after correction for either radiofrequency backscattering (BVS 34.4% vs. EES 22.6%) or echogenicity (BVS 25.2% vs. EES 9.7%). PV change in device segment was differently affected by BVS and EES devices implantation due to their differences in device volume and ultrasound backscattering. It implies that the lumen volume was also artifactually affected by the type of device implanted. Comparative IVUS assessment of lumen and plaque/media volume changes following implantation of BVS and EES requires specific methodological adjustment.
authors.affiliation: ThoraxCentre, Erasmus Medical Center, Rotterdam, The Netherlands.|The Emergency & Critical Care Center of Beijing Anzhen Hospital, Capital Medical University, Beijing, People's Republic of China.
authors.forename: Yaping
authors.initials: Y
authors.lastname: Zeng
authors.affiliation: ThoraxCentre, Erasmus Medical Center, Rotterdam, The Netherlands.
authors.forename: Rafael
authors.initials: R
authors.lastname: Cavalcante
authors.affiliation: ThoraxCentre, Erasmus Medical Center, Rotterdam, The Netherlands.
authors.forename: Erhan
authors.initials: E
authors.lastname: Tenekecioglu
authors.affiliation: Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: Pannipa
authors.initials: P
authors.lastname: Suwannasom
authors.affiliation: Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: Yohei
authors.initials: Y
authors.lastname: Sotomi
authors.affiliation: Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: Carlos
authors.initials: C
authors.lastname: Collet
authors.affiliation: Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: Mahammad
authors.initials: M
authors.lastname: Abdelghani
authors.affiliation: Cardialysis BV, Rotterdam, The Netherlands.
authors.forename: Hans
authors.initials: H
authors.lastname: Jonker
authors.affiliation: The Cardiology Department, Centre Cardiologique du Nord, Saint Denis, France.
authors.forename: Franck
authors.initials: F
authors.lastname: Digne
authors.affiliation: The Department of Cardiology, Heart and Diabetes Center North Rhine-Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany.
authors.forename: Dieter
authors.initials: D
authors.lastname: Horstkotte
authors.affiliation: Department of Cardiology and Angiology, Heart Center University of Freiburg, Freiburg, Germany.
authors.forename: Manfred
authors.initials: M
authors.lastname: Zehender
authors.affiliation: Division of Cardiology, Department of Medical and Surgical Sciences, University Magna Graecia, Campus di Germaneto, Catanzaro, Italy.
authors.forename: Ciro
authors.initials: C
authors.lastname: Indolfi
authors.affiliation: Cardiology Institute, Policlinico S. Orsola-Malpighi, University of Bologna, Bologna, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Saia
authors.affiliation: Division of Cardiology, San Camillo Hospital, Rome, Italy.
authors.forename: Rosario
authors.initials: R
authors.lastname: Fiorilli
authors.affiliation: Institute Jacques Cartier, Massy, France.
authors.forename: Bernard
authors.initials: B
authors.lastname: Chevalier
authors.affiliation: Cardiovascular and Neurological Department, Azienda Ospedaliera Arezzo, Arezzo, Italy.
authors.forename: Leonardo
authors.initials: L
authors.lastname: Bolognese
authors.affiliation: Department of Interventional Cardiology, Puerta de Hierro University Hospital, Madrid, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Goicolea
authors.affiliation: The Emergency & Critical Care Center of Beijing Anzhen Hospital, Capital Medical University, Beijing, People's Republic of China.
authors.forename: Shaoping
authors.initials: S
authors.lastname: Nie
authors.affiliation: ThoraxCentre, Erasmus Medical Center, Rotterdam, The Netherlands.|Cardialysis BV, Rotterdam, The Netherlands.
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Onuma
authors.affiliation: International Centre for Circulatory Health, Imperial College London, South Kensington Campus, London, SW7 2AZ, UK. patrick.w.j.c.serruys@gmail.com.|, Westblaak 98, 3012KM, Rotterdam, The Netherlands. patrick.w.j.c.serruys@gmail.com.
authors.forename: Patrick W
authors.initials: PW
authors.lastname: Serruys
mesh_terms: D020341:Absorbable Implants; D000368:Aged; D002317:Cardiovascular Agents / Q000008:administration & dosage* / Q000009:adverse effects; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging* / Q000473:pathology / Q000628:therapy*; D003331:Coronary Vessels / Q000000981:diagnostic imaging* / Q000473:pathology; D016208:Databases, Factual; D054855:Drug-Eluting Stents; D000068338:Everolimus / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008297:Male; D008670:Metals; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects / Q000295:instrumentation*; D058226:Plaque, Atherosclerotic; D011237:Predictive Value of Tests; D011446:Prospective Studies; D011474:Prosthesis Design; D016037:Single-Blind Method; D013997:Time Factors; D016896:Treatment Outcome; D018084:Ultrasonography, Interventional
chemical_list: D002317:Cardiovascular Agents; D008670:Metals; D000068338:Everolimus
keywords: Absorb II; Bioresorbable vascular scaffold; IVUS; Plaque/media volume