title: Adipokines: A Possible Contribution to Vascular and Bone Remodeling in Idiopathic Pulmonary Arterial Hypertension.
abstract: Osteoporosis is a major comorbidity of cardio-respiratory diseases, but the mechanistic links between pulmonary arterial hypertension and bone remain elusive. The purpose of the stud was to evaluate serum adipokines and endothelin-1 (ET-1) levels in the patients with idiopathic pulmonary arterial hypertension (IPAH) NYHA class III-IV and to determine its associations with bone mineral density (BMD). Pulmonary and hemodynamic parameters, BMD Z-scores at the lumbar spine (LS) and femoral neck (FN), serum leptin, adiponectin, visfatin and endothelin-1 (ET-1), were evaluated in 32 patients with IPAH NYHA class III-IV and 30 healthy volunteers. Leptin, adiponectin and ET-1 were higher in the patients with IPAH than in healthy subjects. Visfatin level showed a tendency to increase compared to that of healthy subjects (p = 0.076). The univariate analysis revealed a positive correlation between BMD Z-scores at both sites and 6-min walk test, and inverse relation with pulmonary vascular resistance (PVR) and mean pulmonary arterial pressure (mPAP). Adiponectin and visfatin showed positive correlations with PVR (p = 0.009 and p = 0.006). Serum adiponectin, visfatin and leptin were inversely associated with Z-scores. After adjusting for BMI and FMI, such associations persisted between visfatin and adiponectin levels and Z-scores at both sites. ET-1 related to mPAP, cardiac index and PVR. Negative correlation was observed between ET-1 and FN BMD (p = 0.01). Positive correlations have revealed between ET-1 and adiponectin (p = 0.02), visfatin (p = 0.004) in IPAH patients. These results provide further evidence that adipokine and endothelial dysregulation may cause not only a decrease in BMD, but also an increase in hemodynamic disorders of IPAH.
authors.affiliation: Central Scientific Research Laboratory, Pacific State Medical University, Vladivostok, Russian Federation. zkochetkova@mail.ru.|Department of Pulmonology, Pacific State Medical University, 2 Ostryakova Av., Vladivostok, Russian Federation, 690950. zkochetkova@mail.ru.
authors.forename: Evgenia A
authors.initials: EA
authors.lastname: Kochetkova
authors.affiliation: Central Scientific Research Laboratory, Pacific State Medical University, Vladivostok, Russian Federation.
authors.forename: Ludmila G
authors.initials: LG
authors.lastname: Ugai
authors.affiliation: Central Scientific Research Laboratory, Pacific State Medical University, Vladivostok, Russian Federation.
authors.forename: Yuliya V
authors.initials: YV
authors.lastname: Maistrovskaia
authors.affiliation: Central Scientific Research Laboratory, Pacific State Medical University, Vladivostok, Russian Federation.
authors.forename: Vera A
authors.initials: VA
authors.lastname: Nevzorova
mesh_terms: D015502:Absorptiometry, Photon / Q000379:methods; D054392:Adipokines / Q000378:metabolism*; D000328:Adult; D015519:Bone Density / Q000502:physiology*; D016723:Bone Remodeling / Q000502:physiology*; D065627:Familial Primary Pulmonary Hypertension / Q000378:metabolism*; D005260:Female; D005272:Femur Neck / Q000378:metabolism; D006801:Humans; D008159:Lumbar Vertebrae / Q000378:metabolism; D008297:Male; D054409:Nicotinamide Phosphoribosyltransferase / Q000378:metabolism; D010024:Osteoporosis / Q000378:metabolism; D066253:Vascular Remodeling
chemical_list: D054392:Adipokines; D054409:Nicotinamide Phosphoribosyltransferase
keywords: Adiponectin; Endothelin-1; Idiopathic pulmonary arterial hypertension; Leptin; Osteoporosis; Visfatin