title: The effects of vitamin B on the immune/cytokine network and their involvement in depression.
abstract: Increasing evidence indicates that there are various interactions between the nervous system and the immune system, and that the immune system plays an important role in the pathogenesis of depression. Pro-inflammatory cytokines (such as IL-1, IL-6, TNF-α) have been implicated in the neurobiological manifestations of depression. The immune/cytokine network has a powerful influence on the brain. In addition, deficiency in B vitamins has been linked to depression. Hence, greater knowledge of how immune cells change in the presence of vitamin B derivatives could improve understanding of how immune changes may correlate with depression, all of which are discussed herein.
authors.affiliation: Centre for Chronic Disease, College of Health and Biomedicine, Victoria University, PO Box 14426, Melbourne, VIC 8001, Australia.
authors.forename: Kathleen
authors.initials: K
authors.lastname: Mikkelsen
authors.affiliation: Centre for Chronic Disease, College of Health and Biomedicine, Victoria University, PO Box 14426, Melbourne, VIC 8001, Australia.
authors.forename: Lily
authors.initials: L
authors.lastname: Stojanovska
authors.affiliation: Centre for Chronic Disease, College of Health and Biomedicine, Victoria University, PO Box 14426, Melbourne, VIC 8001, Australia.
authors.forename: Monica
authors.initials: M
authors.lastname: Prakash
authors.affiliation: Centre for Chronic Disease, College of Health and Biomedicine, Victoria University, PO Box 14426, Melbourne, VIC 8001, Australia. Electronic address: vasso.apostolopoulos@vu.edu.au.
authors.forename: Vasso
authors.initials: V
authors.lastname: Apostolopoulos
mesh_terms: D016207:Cytokines / Q000276:immunology*; D003863:Depression / Q000276:immunology*; D006801:Humans; D007107:Immune System; D007375:Interleukin-1 / Q000276:immunology; D015850:Interleukin-6 / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology; D014803:Vitamin B Complex / Q000276:immunology*; D014804:Vitamin B Deficiency / Q000150:complications*
chemical_list: D016207:Cytokines; D007375:Interleukin-1; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D014803:Vitamin B Complex
keywords: Depression; Immune cells; Immune system; Inflammation; Mental health