title: Nanosystem composed with MSNs, gadolinium, liposome and cytotoxic peptides for tumor theranostics.
abstract: A dual-functional delivery system, based on mesoporous silica nanoparticles (MSNs) with the integration of Magnetic Resonance (MR) imaging and therapeutic peptide delivery, is reported in this paper. A lipid bilayer is attached onto the surface of the nanoparticles, following the doping of Gadolinium (Gd), a paramagnetic lanthanide ion. The liposome-coated GdMSNs exhibit improved colloidal stability, better biocompatibility and more efficient cellular uptake. The Gd renders the nano carrier a potential T1 contrast agent, confirmed by the MR imaging. A pro-apoptotic peptide, KLA (HGGKLAKLAKKLAKLAK), is encapsulated into the GdMSNs-LP and enters into the cells successfully to induce mitochondrial swelling and apoptosis, while it is nontoxic outside the cells. The synthesis procedure is convenient and free of toxic organic reagents. The nanosystem we construct may contribute to a promising theranostic platform for therapeutic peptide delivery in cancer treatment.
authors.affiliation: Suzhou Institute of Nano-tech and Nano-bionics, Chinese Academy of Sciences, 398 Ruoshui Road, Dushu Lake Higher Education Town, Suzhou Industrial Park, Suzhou, 215125, China; University of Chinese Academy of Sciences, 19(A) Yuquan Road, Beijing, 100039, China.
authors.forename: Yaqing
authors.initials: Y
authors.lastname: Jin
authors.affiliation: Suzhou Institute of Nano-tech and Nano-bionics, Chinese Academy of Sciences, 398 Ruoshui Road, Dushu Lake Higher Education Town, Suzhou Industrial Park, Suzhou, 215125, China; University of Chinese Academy of Sciences, 19(A) Yuquan Road, Beijing, 100039, China.
authors.forename: Nengpan
authors.initials: N
authors.lastname: Zhang
authors.affiliation: Suzhou Institute of Nano-tech and Nano-bionics, Chinese Academy of Sciences, 398 Ruoshui Road, Dushu Lake Higher Education Town, Suzhou Industrial Park, Suzhou, 215125, China; University of Chinese Academy of Sciences, 19(A) Yuquan Road, Beijing, 100039, China.
authors.forename: Chunlin
authors.initials: C
authors.lastname: Li
authors.affiliation: Suzhou Institute of Nano-tech and Nano-bionics, Chinese Academy of Sciences, 398 Ruoshui Road, Dushu Lake Higher Education Town, Suzhou Industrial Park, Suzhou, 215125, China.
authors.forename: Kefeng
authors.initials: K
authors.lastname: Pu
authors.affiliation: Suzhou Institute of Nano-tech and Nano-bionics, Chinese Academy of Sciences, 398 Ruoshui Road, Dushu Lake Higher Education Town, Suzhou Industrial Park, Suzhou, 215125, China; China Pharmaceutical University, 639 Longmian Avenue, Jiangning District, Nanjing, 211198, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Ding
authors.affiliation: Suzhou Institute of Nano-tech and Nano-bionics, Chinese Academy of Sciences, 398 Ruoshui Road, Dushu Lake Higher Education Town, Suzhou Industrial Park, Suzhou, 215125, China. Electronic address: ymzhu2008@sinano.ac.cn.
authors.forename: Yimin
authors.initials: Y
authors.lastname: Zhu
mesh_terms: D000368:Aged; D000818:Animals; D017209:Apoptosis; D001672:Biocompatible Materials / Q000737:chemistry; D003102:Colloids / Q000737:chemistry; D003287:Contrast Media / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods; D005260:Female; D005682:Gadolinium / Q000737:chemistry*; D006461:Hemolysis; D006801:Humans; D008081:Liposomes / Q000737:chemistry*; D061986:MCF-7 Cells; D008279:Magnetic Resonance Imaging; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D008928:Mitochondria / Q000378:metabolism; D053758:Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000628:therapy; D010455:Peptides / Q000737:chemistry*; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry; D000068936:Theranostic Nanomedicine / Q000379:methods*
chemical_list: D001672:Biocompatible Materials; D003102:Colloids; D003287:Contrast Media; D008081:Liposomes; D010455:Peptides; D012822:Silicon Dioxide; D005682:Gadolinium
keywords: Liposome; MR contrast agent; Mesoporous silica nanoparticles; Pro-apoptotic peptide delivery; Theranostics