title: Emerging role of HMGB1 in lung diseases: friend or foe.
abstract: Lung diseases remain a serious problem for public health. The immune status of the body is considered to be the main influencing factor for the progression of lung diseases. HMGB1 (high-mobility group box 1) emerges as an important molecule of the body immune network. Accumulating data have demonstrated that HMGB1 is crucially implicated in lung diseases and acts as independent biomarker and therapeutic target for related lung diseases. This review provides an overview of updated understanding of HMGB1 structure, release styles, receptors and function. Furthermore, we discuss the potential role of HMGB1 in a variety of lung diseases. Further exploration of molecular mechanisms underlying the function of HMGB1 in lung diseases will provide novel preventive and therapeutic strategies for lung diseases.
authors.affiliation: Beijing Key Lab of Basic Study on Traditional Chinese Medicine (TCM) Infectious Diseases, Beijing Research Institute of TCM, Beijing Hospital of TCM affiliated to Capital Medical University, Beijing, China.
authors.forename: Junying
authors.initials: J
authors.lastname: Ding
authors.affiliation: Beijing Key Lab of Basic Study on Traditional Chinese Medicine (TCM) Infectious Diseases, Beijing Research Institute of TCM, Beijing Hospital of TCM affiliated to Capital Medical University, Beijing, China.
authors.forename: Xuran
authors.initials: X
authors.lastname: Cui
authors.affiliation: Beijing Key Lab of Basic Study on Traditional Chinese Medicine (TCM) Infectious Diseases, Beijing Research Institute of TCM, Beijing Hospital of TCM affiliated to Capital Medical University, Beijing, China.
authors.forename: Qingquan
authors.initials: Q
authors.lastname: Liu
mesh_terms: D015415:Biomarkers; D024243:HMGB1 Protein / Q000235:genetics*; D006801:Humans; D008168:Lung / Q000378:metabolism / Q000473:pathology; D008171:Lung Diseases / Q000235:genetics* / Q000473:pathology; D058990:Molecular Targeted Therapy; D011971:Receptors, Immunologic / Q000235:genetics
chemical_list: D015415:Biomarkers; D024243:HMGB1 Protein; C585491:HMGB1 protein, human; D011971:Receptors, Immunologic
keywords: high-mobility group box 1; lung diseases; receptor for advanced glycation end product; target therapy