title: Advantages of Structure-Based Drug Design Approaches in Neurological Disorders.
abstract: OBJECTIVE
  The purpose of the review is to portray the theoretical concept on neurological disorders from research data.
  
  
  BACKGROUND
  The freak changes in chemical response of nerve impulse causes neurological disorders. The research evidence of the effort done in the older history suggests that the biological drug targets and their effective feature with responsive drugs could be valuable in promoting the future development of health statistics structure for improved treatment for curing the nervous disorders.
  
  
  METHODS
  In this review, we summarized the most iterative theoretical concept of structure based drug design approaches in various neurological disorders to unfathomable understanding of reported information for future drug design and development.
  
  
  RESULTS
  On the premise of reported information we analyzed the model of theoretical drug designing process for understanding the mechanism and pathology of the neurological diseases which covers the development of potentially effective inhibitors against the biological drug targets. Finally, it also suggests the management and implementation of the current treatment in improving the human health system behaviors.
  
  
  CONCLUSIONS
  With the survey of reported information we concluded the development strategies of diagnosis and treatment against neurological diseases which leads to supportive progress in the drug discovery.
authors.affiliation: Computer Aided Drug Design and Molecular Modeling Lab, Department of Bioinformatics, Alagappa University, Karaikudi-630004, Tamil Nadu, India.
authors.forename: Murali
authors.initials: M
authors.lastname: Aarthy
authors.affiliation: Computer Aided Drug Design and Molecular Modeling Lab, Department of Bioinformatics, Alagappa University, Karaikudi-630004, Tamil Nadu, India.
authors.forename: Umesh
authors.initials: U
authors.lastname: Panwar
authors.affiliation: Department of Chemical Engineering, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Postal Code: 143-701, Seoul, Korea.
authors.forename: Chandrabose
authors.initials: C
authors.lastname: Selvaraj
authors.affiliation: Computer Aided Drug Design and Molecular Modeling Lab, Department of Bioinformatics, Alagappa University, Karaikudi-630004, Tamil Nadu, India.
authors.forename: Sanjeev Kumar
authors.initials: SK
authors.lastname: Singh
mesh_terms: D000818:Animals; D015195:Drug Design; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D009422:Nervous System Diseases / Q000188:drug therapy*; D013329:Structure-Activity Relationship
keywords: Computational Aided drug design; Drug delivery; Neurological disorders; Structure based drug design; Targets