title: Attenuating effects of caffeic acid phenethyl ester with intralipid on hepatotoxicity of chlorpyrifos in the case of rats.
abstract: BACKGROUND
  Chlorpyrifos (CPF), insecticide widely used in agriculture, may cause poisonings in the case of humans. As a result, there is a large amount of treatment research underway to focus on the possibility of chlorpyrifos induced poisonings. The aim of this study has been to evaluate the effects of caffeic acid phenethyl ester (CAPE) and intralipid (IL) on hepatotoxicity induced by chlorpyrifos in the case of rats.
  
  
  METHODS
  The rats in this study were treated with CPF (10 mg/kg body weight (b.w.), orally), CAPE (10 μmol/kg b.w., intraperitoneally), IL (18.6 ml/kg b.w., orally), CPF+CAPE, CPF+IL, and CPF+CAPE+IL. The plasma total oxidant capacity (TOC), total antioxidant capacity (TAC) were measured and the oxidative stress index (OSI) was calculated. Liver histopathology and immunohistochemical staining were performed.
  
  
  RESULTS
  Chlorpyrifos statistically significantly decreased the TAC levels in the rats' plasma and increased the apoptosis and the TOC and OSI levels. In the chlorpyrifos induced liver injury, CAPE and CAPE+IL significantly decreased the plasma OSI levels and the apoptosis, and significantly increased the plasma TAC levels.
  
  
  CONCLUSIONS
  This study revealed that CAPE and CAPE+IL attenuate chlorpyrifos induced liver injuries by decreasing oxidative stress and apoptosis. Med Pr 2016;67(6):743-749.
authors.affiliation: Mustafa Kemal University, Hatay, Turkey (Faculty of Medicine, Department of Physiology). drecepfatih@gmail.com.
authors.forename: Recep
authors.initials: R
authors.lastname: Dokuyucu
authors.affiliation: Ankara University, Ankara, Turkey (Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology).
authors.forename: Ali
authors.initials: A
authors.lastname: Bilgili
authors.affiliation: Ataturk University, Erzurum, Turkey (Faculty of Veterinary Medicine, Department of Internal Medicine).
authors.forename: Basak
authors.initials: B
authors.lastname: Hanedan
authors.affiliation: Mustafa Kemal University, Hatay, Turkey (Faculty of Medicine, Department of Physiology). hatice.hdogan@gmail.com.
authors.forename: Hatice
authors.initials: H
authors.lastname: Dogan
authors.affiliation: Lumina - The University of South-East Europe, Bucharest, Romania (Faculty of Mathematics and Computer Science, Department of Information Technology). ahmetdokuyucu@yahoo.com.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Dokuyucu
authors.affiliation: Mustafa Kemal University, Hatay, Turkey (Faculty of Medicine, Department of Internal Medicine).
authors.forename: Muhammed Murat
authors.initials: MM
authors.lastname: Celik
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D002109:Caffeic Acids / Q000494:pharmacology*; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood*; D004390:Chlorpyrifos / Q000031:analogs & derivatives* / Q000633:toxicity; D007120:Immunochemistry; D018384:Oxidative Stress / Q000187:drug effects*; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000975:Antioxidants; D002109:Caffeic Acids; C055494:caffeic acid phenethyl ester; D004390:Chlorpyrifos; D010626:Phenylethyl Alcohol; C007031:chlorpyrifos-methyl
keywords: apoptosis; caffeic acid phenethyl ester; chlorpyrifos; liver; oxidative stress; rats