title: Impact of a 6-month treatment with intragastric balloon on body composition and psychopathological profile in obese individuals with metabolic syndrome.
abstract: BACKGROUND
  The aim of this study was to investigate the effects of a 6-month treatment with intragastric balloon (IGB) on body composition and depressive/anxiety symptoms in obese individuals with metabolic syndrome (MS).
  
  
  METHODS
  Fifty patients (aged 18-50 years) with obesity and MS were selected for treatment with IGB for 6 months. Body composition was verified with dual-energy X-ray absorptiometry (DXA) at baseline and right after IGB removal. Anxiety/depressive symptoms were assessed with the Beck Depression Inventory (BDI) and the hospital anxiety and depression scale (HADS) at baseline and after 6 months of treatment.
  
  
  RESULTS
  In total, 39 patients completed the study. After 6 months, there were significant decreases in weight (11.7 ± 9.6 kg, p < 0.0001) and waist circumference (9.3 ± 8.2 cm, p < 0.0001). Weight loss was also demonstrated by DXA and corresponded to decreases of 3.0 ± 3.4% in body fat percentage, 7.53 ± 7.62 kg in total body fat, and 3.70 ± 4.89 kg in lean body mass (p < 0.001 for all comparisons). Depressive symptoms scores decreased by a mean of 4.57 ± 10.6 points when assessed with the BDI (p = 0.002) and 1.82 ± 5.16 points when assessed with the HADS-Depression (p = 0.0345). Anxiety symptoms scores decreased by a mean of 1.84 ± 4.04 points when determined with the HADS-anxiety (p = 0.0066). The decrease in body fat percentage was the parameter that best correlated with improvements in depressive (p = 0.008) and anxiety symptoms (p = 0.014).
  
  
  CONCLUSIONS
  In obese individuals with MS, fat mass reduction was associated with short-term improvements in depressive and anxiety symptoms.Trial RegistrationRegistered at ClinicalTrials.gov, NCT01598233.
authors.affiliation: Division of Metabology, State Institute of Diabetes and Endocrinology (IEDE), Rua Moncorvo Filho 90-Centro, Rio de Janeiro, RJ CEP 20211-340 Brazil ; Division of Endocrinology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Erika P
authors.initials: EP
authors.lastname: Guedes
authors.affiliation: Division of Endocrinology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil ; Division of Gastroenterology, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Madeira
authors.affiliation: Division of Pulmonology, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Thiago T
authors.initials: TT
authors.lastname: Mafort
authors.affiliation: Division of Endocrinology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Miguel
authors.initials: M
authors.lastname: Madeira
authors.affiliation: Division of Metabology, State Institute of Diabetes and Endocrinology (IEDE), Rua Moncorvo Filho 90-Centro, Rio de Janeiro, RJ CEP 20211-340 Brazil ; Division of Endocrinology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Rodrigo O
authors.initials: RO
authors.lastname: Moreira
authors.affiliation: Division of Rheumatology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Laura Maria C
authors.initials: LM
authors.lastname: Mendonça
authors.affiliation: Division of Metabology, State Institute of Diabetes and Endocrinology (IEDE), Rua Moncorvo Filho 90-Centro, Rio de Janeiro, RJ CEP 20211-340 Brazil.
authors.forename: Amélio F
authors.initials: AF
authors.lastname: Godoy-Matos
authors.affiliation: Division of Pulmonology, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Agnaldo J
authors.initials: AJ
authors.lastname: Lopes
authors.affiliation: Division of Endocrinology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Maria Lucia F
authors.initials: ML
authors.lastname: Farias
keywords: Anxiety; Body composition; Depression; Intragastric balloon; Obesity