title: GABA Australis, some reflections on the history of GABA receptor research in Australia.
abstract: Research on GABA receptors has a long history in Australia dating from 1958 with David Curtis and his colleagues in Canberra. This review traces many of the advances made in Australia guided by highly cited publications and some obscure ones. It covers the discovery of key chemicals with which to investigate GABA receptor function including bicuculline, muscimol, phaclofen, THIP and (+)-CAMP. Also described are findings relevant to the involvement of mutant GABA receptors in inherited epilepsy. The modulation of GABA receptors by a bewildering range of chemicals, especially by flavonoids and terpenoids, is discussed.
authors.affiliation: Pharmacology, School of Medical Sciences, The University of Sydney, NSW 2006, Australia. Electronic address: grahamj@mail.usyd.edu.au.
authors.forename: Graham A R
authors.initials: GAR
authors.lastname: Johnston
mesh_terms: D000818:Animals; D001315:Australia; D001418:Baclofen / Q000031:analogs & derivatives / Q000378:metabolism; D001640:Bicuculline / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism; D006801:Humans; D007555:Isoxazoles / Q000378:metabolism; D009118:Muscimol / Q000378:metabolism; D018079:Receptors, GABA / Q000378:metabolism*
chemical_list: D007555:Isoxazoles; D018079:Receptors, GABA; C052329:phaclofen; D009118:Muscimol; D000242:Cyclic AMP; D001418:Baclofen; C015542:gaboxadol; D001640:Bicuculline
keywords: Bicuculline; Epilepsy; Flavonoids; GABA; Modulators; Muscimol