title: Recapitulating the Micromechanical Behavior of Tension and Shear in a Biomimetic Hydrogel for Controlling Tenocyte Response.
abstract: A fiber composite system is presented which recapitulates the fiber-composite-like nature of tissues and generates similar modes of shear and tension. The shear/tension ratio can be customized during composite manufacture and incorporates viable cells. The system is a valuable tool for mechanotransduction research, providing a platform with physiologically relevant conditions for investigating cell behavior in different tissue types.
authors.affiliation: School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London, E1 4NS, UK.
authors.forename: Dharmesh
authors.initials: D
authors.lastname: Patel
authors.affiliation: Department of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO, 80303, USA.
authors.forename: Sadhana
authors.initials: S
authors.lastname: Sharma
authors.affiliation: Department of Chemical and Biological Engineering, Material Science and Engineering Program, BioFrontiers Institute, University of Colorado, Boulder, CO, 80303, USA.
authors.forename: Stephanie J
authors.initials: SJ
authors.lastname: Bryant
authors.affiliation: School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London, E1 4NS, UK.
authors.forename: Hazel R C
authors.initials: HR
authors.lastname: Screen
mesh_terms: D000818:Animals; D040761:Biomimetic Materials / Q000737:chemistry*; D002417:Cattle; D020100:Hydrogels / Q000737:chemistry*; D040542:Mechanotransduction, Cellular; D051381:Rats; D033081:Shear Strength; D013710:Tendons / Q000166:cytology* / Q000378:metabolism*
chemical_list: D020100:Hydrogels
keywords: fiber composites; mechanical properties; mechanotransduction; poly(ethylene glycol); tenocyte