title: Nutraceutical properties of cumin residue generated from Ayurvedic industries using cell line models.
abstract: Spent cumin (SC), generated from Ayurvedic industry, was evaluated for its nutraceutical potential in terms of antioxidant, antidiabetic and anticancer properties, and compared with that of the raw cumin (RC). SC and RC seeds were extracted with ethyl acetate (E) and methanol (M). SCM (methanol extract) were rich in p-coumaric acid, ferulic acid, ellagic acid and cinnamic acid (6.4445, 5.8286, 2.1519, 4.3085 mg/g dry extract). SCM reduced Fe2+ion (89.68 µM AA/g dry weight), scavenged DPPH radical (IC50-238.6 µg/mL), better α-amylase inhibition (IC50-337.22 µg/mL) and glucose uptake activity in 30.7% of L6 cells. SCM inhibited viability, retarded migration area up to 41.02%, arrested cell cycle at S phase and induced apoptosis in 2.45% of HT29 colon cancer cells. The results indicated that dietary interventions using nutraceutical food formulation made out of SC can play a significant role in the prevention and management of degenerative diseases.
authors.affiliation: Agro Processing and Natural Products Division, National Institute for Interdisciplinary Science and Technology (CSIR-NIIST), Thiruvananthapuram, Kerala 695019 India.
authors.forename: K B
authors.initials: KB
authors.lastname: Arun
authors.affiliation: Agro Processing and Natural Products Division, National Institute for Interdisciplinary Science and Technology (CSIR-NIIST), Thiruvananthapuram, Kerala 695019 India.
authors.forename: U
authors.initials: U
authors.lastname: Aswathi
authors.affiliation: Agro Processing and Natural Products Division, National Institute for Interdisciplinary Science and Technology (CSIR-NIIST), Thiruvananthapuram, Kerala 695019 India.
authors.forename: V V
authors.initials: VV
authors.lastname: Venugopal
authors.affiliation: Arya Vaidya Sala, Kottakkal, Malappuram District, Kerala 675603 India.
authors.forename: T S
authors.initials: TS
authors.lastname: Madhavankutty
authors.affiliation: Agro Processing and Natural Products Division, National Institute for Interdisciplinary Science and Technology (CSIR-NIIST), Thiruvananthapuram, Kerala 695019 India.
authors.forename: P
authors.initials: P
authors.lastname: Nisha
keywords: Anticancer; Antidiabetic; Nutraceutical; Polyphenols; Spent cumin