title: Bone marrow concentrated cells and stromal vascular fraction cells injections for osteoarthritis treatment: a systematic review.
abstract: The aim of this systematic review is to examine current clinical evidences supporting the intraarticular injection of bone marrow concentrate cells (BMC) and adipose-derived stromal vascular fraction cells (SVF) for the treatment of osteoarthritis (OA). The research was performed on PubMed (Medline), EMBASE and Cochrane Library considering the English literature. Only clinical trials have been included. The systematic research identified twelve clinical trials. Articles included in the study, were one of level II, four of level III, six of level IV and one level V. Among clinical trials, none were randomized, four were comparative, seven were case series, and one was a case report. Seven studies were focused on the use of SVF (1332 patients) and five on the use of BMC (963 patients), with preliminary interesting findings in the OA treatment. Despite the growing interest in this biological approach for OA, knowledge on this topic is still preliminary. Randomized controlled trials are needed to support the potential of BMC and SVF injections and to evaluate advantages and disadvantages with respect to the available treatments.
authors.affiliation: UOC di Ortopedia e Traumatologia, Università Campus Bio-Medico di Roma, Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Vadalà
authors.affiliation: UOC di Ortopedia e Traumatologia, Università Campus Bio-Medico di Roma, Rome, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Papalia
authors.affiliation: UOSD Ortopedia Oncologica, Dipartimento SBIMORF, Università degli Studi di Messina, Messina, Italy.
authors.forename: L
authors.initials: L
authors.lastname: La Verde
authors.affiliation: UOC di Ortopedia e Traumatologia, Università Campus Bio-Medico di Roma, Rome, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Russo
authors.affiliation: UOC di Ortopedia e Traumatologia, Università Campus Bio-Medico di Roma, Rome, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Denaro
authors.affiliation: UOSD Ortopedia Oncologica, Dipartimento SBIMORF, Università degli Studi di Messina, Messina, Italy.
authors.forename: M A
authors.initials: MA
authors.lastname: Rosa
mesh_terms: D000273:Adipose Tissue / Q000166:cytology; D001854:Bone Marrow Cells / Q000166:cytology; D016026:Bone Marrow Transplantation; D006801:Humans; D007270:Injections, Intra-Articular; D010003:Osteoarthritis / Q000473:pathology / Q000628:therapy*; D017154:Stromal Cells / Q000166:cytology / Q000637:transplantation*