title: New phenylpropanoid derivatives from the fruits of Xanthium sibiricum and their anti-inflammatory activity.
abstract: The fruits of Xanthium sibiricum Patr yielded five phenylpropanoid derivatives, named as xanthiumnolics A-E (1-5). Their structures were elucidated by spectroscopic analysis and comparison with literature data. The isolated ones were tested for their anti-inflammatory activities on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7, and compound 5 showed strong inhibitory activities with IC50value of 8.73μM.
authors.affiliation: Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, PR China; Key Laboratory of Chinese MateriaMedica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, PR China.
authors.forename: Hai
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Key Laboratory of Chinese MateriaMedica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, PR China.
authors.forename: Liu
authors.initials: L
authors.lastname: Yang
authors.affiliation: Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, PR China.
authors.forename: Guo-Xu
authors.initials: GX
authors.lastname: Ma
authors.affiliation: Key Laboratory of Chinese MateriaMedica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, PR China.
authors.forename: Xu-Dong
authors.initials: XD
authors.lastname: Xing
authors.affiliation: Key Laboratory of Chinese MateriaMedica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, PR China.
authors.forename: Mei-Ling
authors.initials: ML
authors.lastname: Yan
authors.affiliation: Key Laboratory of Chinese MateriaMedica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, PR China.
authors.forename: Yan-Yan
authors.initials: YY
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Chinese MateriaMedica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, PR China; Guangdong Pharmaceutical University, Guangzhou 528458, PR China.
authors.forename: Qiu-Hong
authors.initials: QH
authors.lastname: Wang
authors.affiliation: Key Laboratory of Chinese MateriaMedica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, PR China.
authors.forename: Bing-You
authors.initials: BY
authors.lastname: Yang
authors.affiliation: Key Laboratory of Chinese MateriaMedica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, PR China. Electronic address: hxkuang56@263.com.
authors.forename: Hai-Xue
authors.initials: HX
authors.lastname: Kuang
authors.affiliation: Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, PR China. Electronic address: xdxu@implad.ac.cn.
authors.forename: Xu-Dong
authors.initials: XD
authors.lastname: Xu
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000302:isolation & purification; D005638:Fruit / Q000737:chemistry*; D008070:Lipopolysaccharides; D008264:Macrophages / Q000187:drug effects*; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000737:chemistry; D064209:Phytochemicals / Q000737:chemistry* / Q000302:isolation & purification; D010936:Plant Extracts / Q000737:chemistry; D000067996:RAW 264.7 Cells; D031210:Xanthium / Q000737:chemistry*
chemical_list: D000893:Anti-Inflammatory Agents; D008070:Lipopolysaccharides; D064209:Phytochemicals; D010936:Plant Extracts; D009569:Nitric Oxide
keywords: Anti-inflammatory activities; Phenylpropanoids; RAW 264.7; X. sibiricum