title: [Effectiveness of Dexrazoxane for Extravasation of Anthracycline Antitumor Antibiotics - Reporting Measures Developed against Extravasation in the Hospital].
abstract: Dexrazoxane(DXZ)is a drug used for treating extravasation(EV)of anthracycline antitumor antibiotics based on 2 of its mechanisms of action through Topo II. In Japan, it has been used in approximately 150 patients as of January 2016, but there is no detailed report. Three DXZ treatments were carried out for 2 cases in our facilities. One case involved a patient's right forearm while 2 cases occurred involved the left and right forearms of each of the patients, and both were Grade 2(CTCAE v4.0). The EV healed in all cases, and surgical procedures were not needed. Moreover, chemotherapy was performed without extending the treatment period. One year 8 months after administration there was no recurrence in both cases, and skin disorders did not develop. In our hospital, DXZ is managed based on the regimen as well as the anticancer agents, and administration within 6 hours from extravasation was made possible by the cooperation of pharmaceutical wholesalers. Nurses and pharmacists who engage in chemotherapy are encouraged to participate in the study sessions of the hospital, it has been the effort to learn the day-to-day knowledge and technology. DXZ is effective in treating the EV of anthracycline antitumor antibiotics and may be well tolerated. To properly use DXZ by integrating these cases, it is necessary to verify its effectiveness and safety.
authors.affiliation: Pharmaceutical Dept. Chibanishi General Hospital.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kawamoto
authors.forename: Takuya
authors.initials: T
authors.lastname: Shirahata
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Katori
authors.forename: Takafumi
authors.initials: T
authors.lastname: Izumo
authors.forename: Hitomi
authors.initials: H
authors.lastname: Kadono
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Fujita
authors.forename: Rumiko
authors.initials: R
authors.lastname: Okamoto
mesh_terms: D018943:Anthracyclines / Q000009:adverse effects* / Q000627:therapeutic use; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects* / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D064730:Dexrazoxane / Q000627:therapeutic use*; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000188:drug therapy*; D005260:Female; D006761:Hospitals; D006801:Humans; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; D000970:Antineoplastic Agents; D064730:Dexrazoxane