title: Bendiocarb induced histopathological and biochemical alterations in rat liver and preventive role of vitamins C and E.
abstract: In this study, biochemical changes and histological structure of rat liver after bendiocarb administration and possible preventive effects of vitamins C and E were studied. The animals were given with bendiocarb, vitamin C and vitamin E, daily 0,8mg/kg of body weight (bw), 100mg/kg-bw and 100mg/kg-bw for 28days, respectively. Lipid peroxidation, antioxidant enzyme activities, histological alterations and antioxidant capacity assays of liver and also liver function tests and lipid profile were measured. Bendiocarb treatment decreased the antioxidant enzyme activities, FRAP and TEAC values and increased malondialdehyde levels compared to control. Also, there were statistically significant alterations in liver function tests, lipid profile parameters and histopathological changes in bendiocarb treated groups. Vitamins C and E showed protective effects against examining parameters. According to results we can say that co-treatment of vitamin C and vitamin E may be more effective than use of them alone.
authors.affiliation: Gazi University, Faculty of Science, Department of Biology, 06500, Ankara, Turkey. Electronic address: fguzun@gazi.edu.tr.
authors.forename: Fatma Gökçe
authors.initials: FG
authors.lastname: Apaydin
authors.affiliation: Bozok University, Faculty of Arts and Science, Department of Biology, 66100, Yozgat, Turkey.
authors.forename: Hatice
authors.initials: H
authors.lastname: Baş
authors.affiliation: Gazi University, Faculty of Gazi Education, Department of Science, 06500, Ankara, Turkey.
authors.forename: Suna
authors.initials: S
authors.lastname: Kalender
authors.affiliation: Gazi University, Faculty of Science, Department of Biology, 06500, Ankara, Turkey.
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Kalender
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology*; D002374:Catalase / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D007306:Insecticides / Q000633:toxicity*; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008297:Male; D048448:Phenylcarbamates / Q000633:toxicity*; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D014810:Vitamin E / Q000494:pharmacology*; D014815:Vitamins / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D007306:Insecticides; D048448:Phenylcarbamates; D014815:Vitamins; D014810:Vitamin E; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005982:Glutathione Transferase; D001205:Ascorbic Acid; C007725:bendiocarb
keywords: Bendiocarb; Histopathology; Liver toxicity; Oxidative stress; Vitamin C; Vitamin E