title: Role of increased mean platelet volume (MPV) and decreased MPV/platelet count ratio as poor prognostic factors in lung cancer.
abstract: OBJECTIVE
  In this study, they investigated whether mean thrombocyte volume (MPV) and MPV/platelet count ratio have a prognostic significance in advanced NSCLC or not.
  
  
  METHODS
  A total of 496 NSCLC patients at stage IIIB/IV and did not meet exclusion criteria were included in the study. The demographic features (age, gender, smoking habit), clinical characteristics (performance status, weight loss, disease stage, first-line treatment regimen), laboratory tests (levels of hemoglobin, lactate dehydrogenase and calcium as well as MPV, MPV/platelet count ratio and counts of white blood cell, platelet), and histological features (histologic type, tumor grade) were recorded.
  
  
  RESULTS
  The MPV levels of all patients were determined as 10.2 {plus minus} 3.4 (range, 6.4-14.1 fL). With ROC curve analysis, the MPV/PC ratio was associated with a sensitivity of 67.8% and a specificity of 84.8% at a cutoff value of 0.47424 for presence of brain metastasis at the time of diagnosis. Univariate analysis showed that OS was significantly shorter in the group with an increased MPV level than in the other group (median OS time 6.8 months vs. 11.5 months, log-rank, P = .032). Multivariate analysis confirmed that an increased MPV level was an independent poor prognostic factor for OS (HR: 1.704, 95% CI: 1.274-3.415, P = .014).
  
  
  CONCLUSIONS
  Unlike results of previous studies, the study showed that increased MPV was an important prognostic factor in patients with NSCLC. Hence, an increased MPV level may be used as a prognostic biomarker to estimate for poor overall survival in patients with NSCLC.
authors.affiliation: Department of Internal Medicine and Medical Oncology, Sitki Kocman University Faculty of Medicine, Mugla, Turkey.
authors.forename: Muhyettin
authors.initials: M
authors.lastname: Omar
authors.affiliation: Department of Internal Medicine and Medical Oncology, Sitki Kocman University Faculty of Medicine, Mugla, Turkey.
authors.forename: Ozgur
authors.initials: O
authors.lastname: Tanriverdi
authors.affiliation: Department of Medical Oncology, Kent Hospital, Izmir, Turkey.
authors.forename: Suna
authors.initials: S
authors.lastname: Cokmert
authors.affiliation: Department of Medical Oncology, Adnan Menderes University Faculty of Medicine, Aydin, Turkey.
authors.forename: Esin
authors.initials: E
authors.lastname: Oktay
authors.affiliation: Department of Medical Oncology, Education and Research Hocpital, Samsun, Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Yersal
authors.affiliation: Department of Medical Oncolgy, Bilim University Faculty of Medicine, Istanbul, Turkey.
authors.forename: Kezban Nur
authors.initials: KN
authors.lastname: Pilancı
authors.affiliation: Department of Medical Oncology, Celal Bayar University Faculty of Medicine, Manisa, Turkey.
authors.forename: Serkan
authors.initials: S
authors.lastname: Menekse
authors.affiliation: Department of Medical Oncology, Education and Research Hospital, Sanliurfa, Turkey.
authors.forename: Muharrem
authors.initials: M
authors.lastname: Kocar
authors.affiliation: Department of Radiation Oncology, Izmir University Medical Park Hospital, Izmir, Turkey.
authors.forename: Cenk Ahmet
authors.initials: CA
authors.lastname: Sen
authors.affiliation: Department of Medical Oncolgy, Bilim University Faculty of Medicine, Istanbul, Turkey.
authors.forename: Cetin
authors.initials: C
authors.lastname: Ordu
authors.affiliation: Department of Medical Oncology, Celal Bayar University Faculty of Medicine, Manisa, Turkey.
authors.forename: Gamze
authors.initials: G
authors.lastname: Goksel
authors.affiliation: Department of Medical Oncology, Adnan Menderes University Faculty of Medicine, Aydin, Turkey.
authors.forename: Nezih
authors.initials: N
authors.lastname: Meydan
authors.affiliation: Department of Medical Oncology, Adnan Menderes University Faculty of Medicine, Aydin, Turkey.
authors.forename: Sabri
authors.initials: S
authors.lastname: Barutca
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets / Q000473:pathology; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood / Q000401:mortality / Q000473:pathology*; D005260:Female; D006801:Humans; D017567:Karnofsky Performance Status / Q000706:statistics & numerical data; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008175:Lung Neoplasms / Q000097:blood / Q000401:mortality / Q000473:pathology*; D008297:Male; D063847:Mean Platelet Volume / Q000379:methods*; D008875:Middle Aged; D009367:Neoplasm Staging; D010976:Platelet Count / Q000379:methods*; D011379:Prognosis; D012907:Smoking / Q000453:epidemiology; D016019:Survival Analysis
chemical_list: D015415:Biomarkers; D007770:L-Lactate Dehydrogenase
keywords: mean platelet volume; non-small-cell lung cancer; prognosis