title: Clinical Profiles of Dengue Infection during an Outbreak in Northern India.
abstract: Introduction.Dengue fever is an arboviral disease, which is transmitted by mosquito vector and presents as varied clinical spectrum of dengue fever (DF), dengue hemorrhagic fever (DHF), dengue shock syndrome (DSS), and expanded dengue syndrome (EDS) with atypical presentations, thus posing a diagnostic dilemma. Unless we are aware of these presentations, diagnosis as well as early initiation of treatment becomes difficult. We studied the various clinical presentations of dengue infection during an outbreak of disease in 2015.Materials and Methods. A total of 115 confirmed cases of dengue infection from Department of Medicine of Deen Dayal Upadhyay Hospital, New Delhi, were enrolled in this observational study.Results.The common signs and symptoms of dengue infection were fever, headache, body ache, backache, retro-orbital pain, bleeding manifestations, and rash in 100%, 87%, 86%, 58%, 41%, 21%, and 21%, respectively. Nonspecific or warning signs and symptoms included vomiting, weakness, abdominal pain, breathlessness, vertigo, sweating, and syncope. Other possible signs and symptoms of coinfections, comorbidities, or complications included diarrhea, sore throat, and neurological manifestations. There were seven patients with coinfections and four with comorbidities. The final diagnosis of these patients was DF (73%), DHF (16.5%), DSS (1.7%), and EDS (4.3%). Among EDS patients, the atypical presentations included encephalopathy, lateral rectus nerve palsy, acalculous cholecystitis, and myocarditis. Four patients required ICU care and there was no death in this study.Conclusion. Knowledge of atypical presentations is a must for early diagnosis and timely intervention to prevent life-threatening complications.
authors.affiliation: Maulana Azad Medical College, No. 2, Bahadur Shah Zafar Marg, New Delhi, Delhi 110002, India.
authors.forename: Anish
authors.identifier: 0000-0001-9741-8339
authors.initials: A
authors.lastname: Laul
authors.affiliation: Deen Dayal Upadhyay Hospital, Hari Nagar, Clock Tower, New Delhi, Delhi 110064, India.
authors.forename: Poonam
authors.identifier: 0000-0003-4553-0622
authors.initials: P
authors.lastname: Laul
authors.affiliation: Deen Dayal Upadhyay Hospital, Hari Nagar, Clock Tower, New Delhi, Delhi 110064, India.
authors.forename: Vamsi
authors.initials: V
authors.lastname: Merugumala
authors.affiliation: Deen Dayal Upadhyay Hospital, Hari Nagar, Clock Tower, New Delhi, Delhi 110064, India.
authors.forename: Ravi
authors.initials: R
authors.lastname: Pathak
authors.affiliation: Deen Dayal Upadhyay Hospital, Hari Nagar, Clock Tower, New Delhi, Delhi 110064, India.
authors.forename: Urvashi
authors.identifier: 0000-0001-5459-8667
authors.initials: U
authors.lastname: Miglani
authors.affiliation: Deen Dayal Upadhyay Hospital, Hari Nagar, Clock Tower, New Delhi, Delhi 110064, India.
authors.forename: Pinkee
authors.identifier: 0000-0003-4953-9974
authors.initials: P
authors.lastname: Saxena