title: Synthesis of Novel Pyrazolines, Their Boron-Fluorine Complexes, and Investigation of Antibacterial, Antioxidant, and Enzyme Inhibition Activities.
abstract: New 3,5-disubstituted-2-pyrazoline derivatives (4-6), their boron-fluorine complexes (boron (3-(2'-aminophenyl),5-(2'-/3'-/4'-pyridyl)pyrazoline, BOAPPY) (7-9) and boron 1,2'-diazaflavone complex (BODAF) (11) were synthesized starting from azachalcones (1-3) to diazaflavone (10), respectively. Biological evaluation of compounds 4-9 and 11 showed remarkable antioxidant, antibacterial, and acetylcholinesterase and tyrosinase enzyme inhibition activities. All newly synthesized compounds 4-9 and 11 showed respectable antibacterial effect with minimum inhibitory concentrations in the range of 4.7-150 μg/mL.
authors.affiliation: Faculty of Science, Department of Chemistry, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: Nuran
authors.initials: N
authors.lastname: Kahriman
authors.affiliation: Faculty of Science, Department of Chemistry, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Haşimoğlu
authors.affiliation: Faculty of Science, Department of Chemistry, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: Vildan
authors.initials: V
authors.lastname: Serdaroğlu
authors.affiliation: Faculty of Arts and Sciences, Department of Biology, Recep Tayyip Erdoğan University, Rize, Turkey.
authors.forename: Fatih Şaban
authors.initials: FŞ
authors.lastname: Beriş
authors.affiliation: Faculty of Pharmacy, Department of Biochemistry, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: Burak
authors.initials: B
authors.lastname: Barut
authors.affiliation: Faculty of Pharmacy, Department of Biochemistry, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: Nurettin
authors.initials: N
authors.lastname: Yaylı
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D000975:Antioxidants / Q000138:chemical synthesis / Q000494:pharmacology*; D001895:Boron / Q000737:chemistry*; D002800:Cholinesterase Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005461:Fluorine / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000494:pharmacology; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000975:Antioxidants; D002800:Cholinesterase Inhibitors; D016166:Free Radical Scavengers; D011720:Pyrazoles; D005461:Fluorine; D014442:Monophenol Monooxygenase; D001895:Boron
keywords: Azachalcone; Azaflavone; BOAPPY; BODAF; Pyrazoline