title: Simultaneous separation and determination of 15 organic UV filters in sunscreen cosmetics by HPLC-ESI-MS/MS.
abstract: OBJECTIVE
  A comprehensive methodology for the simultaneous determination of 15 multiclass organic UV filters in sunscreen cosmetics was developed using high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS).
  
  
  METHODS
  Sunscreen cosmetics of various matrices, such as toning lotion, emulsion, cream and lipstick, were analysed. Ultrasound-assisted extraction (UAE) was utilized as the extraction technique for sample preparation. The 15 UV filters were chromatographically separated by two groups of mobile phase system on an XBridge C18analytical column (150 × 2.1 mm I.D., 3.5 μm particle size) and quantified using HPLC-ESI-MS/MS. The quantitation was performed using the external calibration method.
  
  
  RESULTS
  The established method was validated in terms of linearity, sensitivity, specificity, accuracy, stability, intraday and interday precisions, recovery and matrix effect. The method was also applied for the determination of UV filters in commercial sunscreen cosmetics.
  
  
  CONCLUSIONS
  The experimental results demonstrated that the developed method was accurate, rapid and sensitive and can be used for the analytical control of sunscreen cosmetics.
authors.affiliation: Chinese Academy of Inspection and Quarantine, Beijing, 100176, China.
authors.forename: X
authors.initials: X
authors.lastname: Meng
authors.affiliation: Chinese Academy of Inspection and Quarantine, Beijing, 100176, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Ma
authors.affiliation: Chinese Academy of Inspection and Quarantine, Beijing, 100176, China.
authors.forename: H
authors.initials: H
authors.lastname: Bai
authors.affiliation: College of Chemistry, Jilin University, Changchun, 130012, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Wenzhou Entry-Exit Inspection and Quarantine Bureau, Wenzhou, 325027, China.
authors.forename: C
authors.initials: C
authors.lastname: Han
authors.affiliation: Shanghai Entry-Exit Inspection and Quarantine Bureau, Shanghai, 200135, China.
authors.forename: C
authors.initials: C
authors.lastname: Wang
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D003358:Cosmetics; D012015:Reference Standards; D015203:Reproducibility of Results; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D013473:Sunscreening Agents / Q000737:chemistry*; D014466:Ultraviolet Rays
chemical_list: D003358:Cosmetics; D013473:Sunscreening Agents
keywords: HPLC-ESI-MS/MS; UV filters; sunscreen cosmetics