title: [Evaluation of malaria rapid diagnostic test Optimal-IT® pLDH along the Plasmodium falciparum distribution limit in Mauritania].
abstract: Performance of the malaria Rapid Diagnostic Test (RDT) OptiMal-IT® was evaluated in Mauritania where malaria is low and dependent on a short transmission season. Slide microscopy was considered as the reference method of diagnosis. Febrile patients with suspected malaria were recruited from six health facilities, 3 urban and 3 rural, during two periods (December 2011 to February 2012, and August 2012 to March 2013). Overall, 780 patients were sampled, with RDT and thick blood film microscopy results being obtained for 759 of them. Out of 774 slides examined, of which 200 were positive, P. falciparum and P. vivax mono-infections were detected in 63.5% (127) and 29.5% (59), while P. falciparum/P. vivax coinfections were detected in 7% (14). Both species were observed in all study sites, although in significantly different proportions. The proportions of thick blood film and OptiMal-IT® RDT positive individuals was 26.3% and 30.3% respectively. Sensitivity and specificity of OptiMal-IT® RDT were 89% [95% CI, 84.7-93.3] and 91.1% [88.6-93.4]. Positives and negative predictive values were 78.1% [72.2-83.7] and 95.9% [94.1-97.5]. These diagnostic values are similar to those generally reported elsewhere, and support the use of RDTs as the main diagnostic tool for malaria in Mauritanian health facilities. In the future, choice of RDTs to be used must take account of thermostability in a hot, dry environment and their ability to detect P. falciparum and P. vivax.
authors.affiliation: Institut national de recherche en santé publique (INRSP), BP 695, Nouakchott, Mauritanie. hampateba2001@yahoo.fr.
authors.forename: H
authors.initials: H
authors.lastname: Ba
authors.affiliation: Hôpital Le Dantec, Université Cheikh Anta Diop, Dakar, Sénégal.
authors.forename: A D
authors.initials: AD
authors.lastname: Ahouidi
authors.affiliation: Department of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.
authors.forename: C W
authors.initials: CW
authors.lastname: Duffy
authors.affiliation: Institut national de recherche en santé publique (INRSP), BP 695, Nouakchott, Mauritanie.
authors.forename: Y B
authors.initials: YB
authors.lastname: Deh
authors.affiliation: Hôpital Le Dantec, Université Cheikh Anta Diop, Dakar, Sénégal.
authors.forename: C
authors.initials: C
authors.lastname: Diedhiou
authors.affiliation: Institut national de recherche en santé publique (INRSP), BP 695, Nouakchott, Mauritanie.
authors.forename: A
authors.initials: A
authors.lastname: Tandia
authors.affiliation: Institut national de recherche en santé publique (INRSP), BP 695, Nouakchott, Mauritanie.
authors.forename: M Y
authors.initials: MY
authors.lastname: Diallo
authors.affiliation: Department of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.
authors.forename: S
authors.initials: S
authors.lastname: Assefa
authors.affiliation: Université des sciences et technologies médicales, Département de biologie, BP 880, Nouakchott, Mauritanie.|Direction de l'inspection générale, av. Gamel Abdel, BP 115, Nouakchott, Mauritanie.
authors.forename: B B
authors.initials: BB
authors.lastname: Lô
authors.affiliation: Institut national de recherche en santé publique (INRSP), BP 695, Nouakchott, Mauritanie.
authors.forename: M B
authors.initials: MB
authors.lastname: Elkory
authors.affiliation: Department of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.
authors.forename: D J
authors.initials: DJ
authors.lastname: Conway
mesh_terms: D000953:Antigens, Protozoan / Q000097:blood; D003955:Diagnostic Tests, Routine / Q000379:methods*; D006801:Humans; D016778:Malaria, Falciparum / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D008435:Mauritania / Q000453:epidemiology; D010963:Plasmodium falciparum / Q000276:immunology; D011237:Predictive Value of Tests; D011933:Reagent Kits, Diagnostic; D012680:Sensitivity and Specificity; D013997:Time Factors
chemical_list: D000953:Antigens, Protozoan; D011933:Reagent Kits, Diagnostic
keywords: Malaria; Mauritania; Optimal-IT® pLDH; RDT; Rapid Diagnostic Test