title: ABCB1-C3435T polymorphism and breast cancer risk: a case-control study and a meta-analysis.
abstract: OBJECTIVE
  To investigate the association of ABCB1-C3435T transition with breast cancer risk which was followed by a meta-analysis.
  
  
  METHODS
  In a case-control study we collected blood samples from 290 women (including 150 breast cancer patients and 140 healthy controls). ABCB1-C3435T genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. A meta-analysis was performed for a total of 13 eligible studies involving 5,835 cases and 8,178 controls.
  
  
  RESULTS
  The results of case-control study revealed a significant association between T allele (OR=1.770, 95%CI=1.236-2.535, p=0.002), CT genotype (OR=1.661, 95%CI=1.017-2.713, p=0.042), and TT genotype (OR=3.399, 95%CI=1.409-8.197, p=0.006) with breast cancer risk. Data from meta-analysis revealed a significant association between ABCB1-C3435T polymorphism and breast cancer risk in allelic (OR=1.243, 95%CI=1.079-1.432, p=0.003), co-dominant (OR=1.349, 95%CI=1.042-1.746, p=0.023), dominant (OR=1.204, 95%CI=1.019-1.422, p=0.029), and recessive (OR=1.226, 95%CI=1.011-1.488, p=0.039) models.
  
  
  CONCLUSIONS
  The results suggest that the ABCB1-C3435T gene polymorphism might be a genetic risk factor and a potential biomarker for breast cancer.
authors.affiliation: Department of Infectious Disease, Kashan University of Medical Sciences, Kashan, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Sharif
authors.forename: Davood
authors.initials: D
authors.lastname: Kheirkhah
authors.forename: Mohammad
authors.initials: M
authors.lastname: Reza Sharif
authors.forename: Mohammad
authors.initials: M
authors.lastname: Karimian
authors.forename: Zahra
authors.initials: Z
authors.lastname: Karimian
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B / Q000235:genetics; D014408:Biomarkers, Tumor / Q000235:genetics*; D001943:Breast Neoplasms / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: C513055:ABCB1 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B; D014408:Biomarkers, Tumor