title: Ag-Assisted Fluorination of Unprotected 4,6-Disubstituted 2-Aminopyrimidines with Selectfluor.
abstract: A direct fluorination of 4,6-disubstituted 2-aminopyrimidines with Selectfluor in the presence of Ag(I) is presented, affording the corresponding 4,6-disubstituted 5-fluoro-2-aminopyrimidines with acceptable to high yield. Ag(I) is crucial for this chemoselective fluorination process. The transformation of 4,6-diphenyl 5-fluoro-2-aminopyrimidine into N-(5-fluoro-4,6-diphenylpyrimidin-2-yl)-4-methylbenzenesulfonamide is discussed, and the reaction mechanism is investigated, as well.
authors.affiliation: Shanghai Key Lab of Chemical Assessment and Sustainability, School of Chemical Technology and Engineering, Tongji University , 1239 Siping Road, Shanghai 200092, People's Republic of China.
authors.forename: Chenxi
authors.initials: C
authors.lastname: Wang
authors.affiliation: Shanghai Key Lab of Chemical Assessment and Sustainability, School of Chemical Technology and Engineering, Tongji University , 1239 Siping Road, Shanghai 200092, People's Republic of China.
authors.forename: Juewang
authors.initials: J
authors.lastname: Cai
authors.affiliation: Shanghai Key Lab of Chemical Assessment and Sustainability, School of Chemical Technology and Engineering, Tongji University , 1239 Siping Road, Shanghai 200092, People's Republic of China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Shanghai Key Lab of Chemical Assessment and Sustainability, School of Chemical Technology and Engineering, Tongji University , 1239 Siping Road, Shanghai 200092, People's Republic of China.
authors.forename: Xiaoming
authors.identifier: 0000-0002-1447-128X
authors.initials: X
authors.lastname: Zhao