title: Targeting Notch3 in Hepatocellular Carcinoma: Molecular Mechanisms and Therapeutic Perspectives.
abstract: The Notch signaling pathway is a very conserved system that controls embryonic cell fate decisions and the maintenance of adult stem cells through cell to cell communication. Accumulating evidence support the relevance of Notch signaling in different human diseases and it is one of the most commonly activated signaling pathways in cancer. This review focuses mainly on the role of Notch3 signaling in hepatocellular carcinoma and its potential therapeutic applications against this malignancy. In this regard, the crosstalk between Notch and p53 may play an important role.
authors.affiliation: Centre for Applied Biomedical Research (CRBA), S. Orsola-Malpighi University Hospital, 40138 Bologna, Italy. catia.giovannini4@unibo.it.|Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy. catia.giovannini4@unibo.it.
authors.forename: Catia
authors.initials: C
authors.lastname: Giovannini
authors.affiliation: Centre for Applied Biomedical Research (CRBA), S. Orsola-Malpighi University Hospital, 40138 Bologna, Italy. luigi.bolondi@unibo.it.|Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy. luigi.bolondi@unibo.it.
authors.forename: Luigi
authors.initials: L
authors.lastname: Bolondi
authors.affiliation: Centre for Applied Biomedical Research (CRBA), S. Orsola-Malpighi University Hospital, 40138 Bologna, Italy. laura.gramantieri@aosp.bo.it.
authors.forename: Laura
authors.initials: L
authors.lastname: Gramantieri
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy / Q000378:metabolism*; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D000071656:Receptor, Notch3 / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D000071656:Receptor, Notch3; D016159:Tumor Suppressor Protein p53
keywords: Notch; hepatocellular carcinoma (HCC); p53