title: Establishment of a Patient-Derived Xenograft of Canine Enteropathy-Associated T-Cell Lymphoma, Large Cell Type.
abstract: The pathogenesis of canine T-cell lymphoma remains incompletely understood, partly because there are no well-established in-vivo models to study these malignancies. For this study, we generated a patient-derived tumour xenograft (PDTX) from a 10-year-old neutered male golden retriever dog with enteropathy-associated intestinal T-cell lymphoma, large cell type. One of two female, 15-week-old beige/nude/XID mice developed a visible tumour 7 weeks after sections of tumour material from the spleen were surgically implanted. The histological appearance, immunophenotype and clonal antigen receptor rearrangements of the tumour from the recipient mouse showed that it was derived from the primary canine tumour. Our results indicate that immunodeficient mice are receptive hosts to develop in-vivo PDTX models to study the pathogenesis and management of canine T-cell lymphomas.
authors.affiliation: Animal Cancer Care and Research Program, University of Minnesota, St. Paul, USA; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, USA; Masonic Cancer Center, University of Minnesota, Minneapolis, USA; Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, USA.
authors.forename: K S
authors.initials: KS
authors.lastname: Im
authors.affiliation: Animal Cancer Care and Research Program, University of Minnesota, St. Paul, USA; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, USA; Masonic Cancer Center, University of Minnesota, Minneapolis, USA.
authors.forename: J H
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Animal Cancer Care and Research Program, University of Minnesota, St. Paul, USA; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, USA; Masonic Cancer Center, University of Minnesota, Minneapolis, USA.
authors.forename: A J
authors.initials: AJ
authors.lastname: Graef
authors.affiliation: Animal Cancer Care and Research Program, University of Minnesota, St. Paul, USA; Masonic Cancer Center, University of Minnesota, Minneapolis, USA; Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, USA.
authors.forename: I
authors.initials: I
authors.lastname: Cornax
authors.affiliation: Animal Cancer Care and Research Program, University of Minnesota, St. Paul, USA; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, USA; Masonic Cancer Center, University of Minnesota, Minneapolis, USA.
authors.forename: D M
authors.initials: DM
authors.lastname: Seelig
authors.affiliation: Animal Cancer Care and Research Program, University of Minnesota, St. Paul, USA; Masonic Cancer Center, University of Minnesota, Minneapolis, USA; Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, USA.
authors.forename: M G
authors.initials: MG
authors.lastname: O'Sullivan
authors.affiliation: Animal Cancer Care and Research Program, University of Minnesota, St. Paul, USA; Masonic Cancer Center, University of Minnesota, Minneapolis, USA; Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, USA.
authors.forename: R C
authors.initials: RC
authors.lastname: Kovi
authors.affiliation: Animal Cancer Care and Research Program, University of Minnesota, St. Paul, USA; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, USA; Masonic Cancer Center, University of Minnesota, Minneapolis, USA. Electronic address: modiano@umn.edu.
authors.forename: J F
authors.initials: JF
authors.lastname: Modiano
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004283:Dog Diseases; D004285:Dogs; D058527:Enteropathy-Associated T-Cell Lymphoma / Q000662:veterinary*; D005260:Female; D064593:Heterografts; D008297:Male; D051379:Mice; D008819:Mice, Nude
keywords: dog; enteropathy-associated T-cell lymphoma; immunodeficient mouse model; patient-derived tumour xenograft