title: Guar gum oleate-graft-poly(methacrylic acid) hydrogel as a colon-specific controlled drug delivery carrier.
abstract: A novel type of ethylene glycol dimethacrylate (EGDMA) cross-linked guar gum oleate-graft-poly(methacrylic acid) (GGO-g-PMAc) hydrogel was prepared as a pH-responsive controlled release carrier for colon-specific drug delivery. The structure of GGO-g-PMAc hydrogel was characterized by FT-IR,1H NMR and X-ray diffraction (XRD) analysis. The swelling degree of the GGO-g-PMAc hydrogel at pH 7.4 was found to be higher than that at pH 1.2. The drug release studies performed in pH 7.4 and 1.2 buffer solutions at 37°C revealed that the rate and amount of drug released from the GGO-g-PMAc hydrogel at pH 7.4 were higher than that at pH 1.2. The MTT assay revealed that there is no noticeable cytotoxicity of GGO-g-PMAc hydrogel at the concentration range of 0-100μg/ml against the mouse mesenchymal stem cell line (C3H10T1/2). These results suggested that GGO-g-PMAc hydrogel can be a prospective pH-sensitive carrier for colon-targeted drug delivery.
authors.affiliation: Department of Chemistry, Hindustan Institute of Technology and Science, Padur, Chennai 603 103, India.
authors.forename: D Sathya
authors.initials: DS
authors.lastname: Seeli
authors.affiliation: Department of Chemistry, Hindustan Institute of Technology and Science, Padur, Chennai 603 103, India. Electronic address: mprabaharan@yahoo.com.
authors.forename: M
authors.initials: M
authors.lastname: Prabaharan
mesh_terms: D000818:Animals; D002460:Cell Line; D003106:Colon; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D065546:Drug Liberation; D005685:Galactans / Q000737:chemistry*; D020100:Hydrogels; D006863:Hydrogen-Ion Concentration; D008351:Mannans / Q000737:chemistry*; D059630:Mesenchymal Stem Cells; D008689:Methacrylates / Q000737:chemistry*; D051379:Mice; D019301:Oleic Acid / Q000737:chemistry*; D053149:Plant Gums / Q000737:chemistry*; D011446:Prospective Studies; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D004337:Drug Carriers; D005685:Galactans; D020100:Hydrogels; D008351:Mannans; D008689:Methacrylates; D053149:Plant Gums; C008384:methacrylic acid; D019301:Oleic Acid; C007894:guar gum
keywords: Colon; Controlled release; Cytotoxicity; Guar gum; Hydrogel