title: Real-life clinical practice and management of polysensitized patients with respiratory allergies: a large, global survey of clinicians prescribing allergen immunotherapy.
abstract: BACKGROUND
  The allermix survey was conducted to gain insights into the most frequently diagnosed allergies worldwide, the use of allergen immunotherapy (AIT) in clinical practice, and to identify current clinical approaches for the management of polyallergic patients.
  
  
  METHODS
  The survey was conducted in 19 countries worldwide during 2016. Clinicians currently prescribing AIT completed an online questionnaire, designed to gather data on their daily clinical practice, most commonly diagnosed and treated allergies among their patients, awareness and adherence to recommendations and guidelines on AIT, the AIT format(s) that they choose to prescribe, and management of polyallergic patients.
  
  
  RESULTS
  Respondents (N = 1029) considered a clinical demonstration of safety and effectiveness, and quality and standardization of allergen extract, as key factors influencing their choice of which AIT formulation to prescribe. 98% of respondents reported managing polyallergic patients; 58% were treated with single-allergen AIT and 42% with multiple-allergen AIT. 74% of respondents were aware of latest AIT practice guidelines, while 67% had an awareness of recent recommendations for pharmaceutical manufacturers.
  
  
  CONCLUSIONS
  These findings highlight the need for high-quality AIT products that are supported by robust efficacy and safety data, and address the treatment habits of allergy specialists in their real-life clinical practice.
authors.affiliation: a Department of Paediatric Pulmonology and Immunology , Charité Virchow-Klinikum, Humboldt University , Berlin , Germany.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Wahn
authors.affiliation: b Section of Allergy and Clinical Immunology , Imperial College London-National Heart and Lung Institute, Royal Brompton Hospital , London , UK.
authors.forename: Moises A
authors.initials: MA
authors.lastname: Calderon
authors.affiliation: c Department of Pulmonology, Division of Allergy , Hôpital Arnaud de Villeneuve, University Hospital of Montpellier, Montpellier and Sorbonne Universités, UPMC Paris 06, UMR-S 1136, IPLESP, Equipe EPAR , Paris , France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Demoly
mesh_terms: D000286:Administration, Sublingual; D000818:Animals; D039741:Antigens, Dermatophagoides / Q000276:immunology / Q000627:therapeutic use*; D052179:Antigens, Plant / Q000276:immunology / Q000627:therapeutic use*; D029662:Betula / Q000276:immunology; D003888:Desensitization, Immunologic / Q000379:methods*; D006801:Humans; D007279:Injections, Subcutaneous; D007391:International Cooperation; D006109:Poaceae / Q000276:immunology; D011058:Pollen / Q000276:immunology; D010818:Practice Patterns, Physicians' / Q000706:statistics & numerical data*; D039981:Pyroglyphidae / Q000276:immunology; D012130:Respiratory Hypersensitivity / Q000453:epidemiology* / Q000276:immunology / Q000628:therapy; D011795:Surveys and Questionnaires
chemical_list: D039741:Antigens, Dermatophagoides; D052179:Antigens, Plant
keywords: Aeroallergens; allergen immunotherapy; clinical practice; multiallergen; polyallergy; survey