title: Prunella vulgaris L., an Edible and Medicinal Plant, Attenuates Scopolamine-Induced Memory Impairment in Rats.
abstract: Prunella vulgaris L. is as a major plant in the Chinese traditional functional beverage Guangdong herbal tea for the treatment of fevers, diarrhea, and sore mouth. In this study, ethyl acetate parts of aqueous extracts from P. vulgaris L. (EtOAc-APV) were found to demonstrate potent acetylcholinesterase (AChE) inhibition in vitro. Therefore, this study was designed to further investigate the effects of EtOAc-APV on scopolamine (SCOP)-induced aging rats. Male Wistar rats were randomly divided into four groups (n = 12) and given orally by gavage EtOAc-APV (100 mg/kg) for 3 weeks. SCOP (1 mg/kg, ip) was administered to rats 30 min before starting behavioral tests consecutively for 3 days. EtOAc-APV could attenuate SCOP-induced brain senescence in rats by improving behavioral performance and decreasing brain cell damage, which was associated with a notable reduction in AChE activity and MDA level, as well as an increase in SOD and GPx activities. Additionally, EtOAc-APV administration could reduce the expression of NF-κB and GFAP, which showed an anti-neuroinflammatory effect on the SCOP-treated rat. Overall, the current study highlights P. vulgaris L. as an antidementia dietary supplement.
authors.affiliation: Tianjin Key Laboratory for Modern Drug Delivery and High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University , Tianjin 300072, China.
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Qu
authors.affiliation: Department of Pharmacy, Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury, Logistics University of Chinese People's Armed Police Forces , Tianjin 300162, China.
authors.forename: Jingze
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Tianjin Key Laboratory for Modern Drug Delivery and High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University , Tianjin 300072, China.
authors.forename: Honggai
authors.initials: H
authors.lastname: Yang
authors.affiliation: Tianjin Key Laboratory for Modern Drug Delivery and High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University , Tianjin 300072, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Gao
authors.affiliation: Department of Pharmacy, Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury, Logistics University of Chinese People's Armed Police Forces , Tianjin 300162, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Chen
authors.affiliation: The State Key Laboratories of Pharmacodynamics and Pharmacokinetics , Tianjin 300193, China.
authors.forename: Changxiao
authors.initials: C
authors.lastname: Liu
authors.affiliation: Tianjin Key Laboratory for Modern Drug Delivery and High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University , Tianjin 300072, China.
authors.forename: Wenyuan
authors.identifier: http://orcid.org/0000-0001-8475-6988
authors.initials: W
authors.lastname: Gao
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D002109:Caffeic Acids / Q000032:analysis; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D002934:Cinnamates / Q000032:analysis; D053630:Depsides / Q000032:analysis; D005419:Flavonoids / Q000032:analysis; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced / Q000188:drug therapy*; D016328:NF-kappa B / Q000378:metabolism; D018696:Neuroprotective Agents / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry; D031347:Prunella / Q000737:chemistry*; D017208:Rats, Wistar; D012601:Scopolamine / Q000009:adverse effects*; D000097123:Rosmarinic Acid
chemical_list: D002109:Caffeic Acids; D002800:Cholinesterase Inhibitors; D002934:Cinnamates; D053630:Depsides; D005419:Flavonoids; D016328:NF-kappa B; D018696:Neuroprotective Agents; D010936:Plant Extracts; D012601:Scopolamine; D000097123:Rosmarinic Acid; C040048:caffeic acid
keywords: Prunella vulgaris L.; acetylcholinesterase inhibitor; chemical components; ethyl acetate parts of aqueous extracts from Prunella vulgaris L.; neuroprotection