title: Cardiodynamicsgram as a New Diagnostic Tool in Coronary Artery Disease Patients With Nondiagnostic Electrocardiograms.
abstract: Cardiodynamicsgram (CDG) has emerged recently as a noninvasive spatiotemporal electrocardiographic method for subtle cardiac dynamics information analysis within electrocardiogram (ECG). This study sought to evaluate the clinical utility of CDG for early coronary artery disease (CAD) detection in suspected patients with CAD presenting with nondiagnostic ECGs. A total of 421 suspected patients with CAD presenting with nondiagnostic ECG were enrolled. Standard 12-lead ECG and CDG were performed simultaneously, 1 day before invasive coronary angiography. Diagnostic accuracy of CDG for early CAD detection was assessed with reference to coronary angiography as the gold standard. Coronary angiography showed ≥1 coronary arteries stenosis of >50% in 347 patients. Of these 347 patients with CAD, 294 patients were positive in CDG. Of 74 non-CAD controls, 63 patients were negative in CDG. Diagnostic accuracy of CDG at presentation for CAD was 84.6%, sensitivity 84.7%, and specificity 83.7%. In patients presenting with nondiagnostic ECGs, an abnormal status can be detected early through noninvasive CDG. CDG is highly sensitive for the early diagnosis of CAD. Underlying causes of false-negative CDG findings included number of diseased coronary arteries and collateral circulation. Subtle myocardial damage that was not detectable on coronary angiography might be the major cause of false-positive findings.
authors.affiliation: College of Automation, South China University of Technology, Guangzhou, China; Key Laboratory of Biomedical Engineering in Guangdong, Guangzhou, China.
authors.forename: Muqing
authors.initials: M
authors.lastname: Deng
authors.affiliation: Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Cardiovascular Institute, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, and Peking Union Medical College, Beijing, China. Electronic address: doctortangmin@hotmail.com.
authors.forename: Min
authors.initials: M
authors.lastname: Tang
authors.affiliation: College of Automation, South China University of Technology, Guangzhou, China; Key Laboratory of Biomedical Engineering in Guangdong, Guangzhou, China. Electronic address: wangcong@scut.edu.cn.
authors.forename: Cong
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Cardiovascular Institute, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, and Peking Union Medical College, Beijing, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Shan
authors.affiliation: Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Cardiovascular Institute, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, and Peking Union Medical College, Beijing, China.
authors.forename: Linfeng
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Cardiovascular Institute, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, and Peking Union Medical College, Beijing, China.
authors.forename: Jingtao
authors.initials: J
authors.lastname: Zhang
authors.affiliation: College of Automation, South China University of Technology, Guangzhou, China; Key Laboratory of Biomedical Engineering in Guangdong, Guangzhou, China.
authors.forename: Weiming
authors.initials: W
authors.lastname: Wu
authors.affiliation: College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Xia
mesh_terms: D000368:Aged; D003097:Collateral Circulation; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000175:diagnosis* / Q000000981:diagnostic imaging; D023921:Coronary Stenosis / Q000175:diagnosis* / Q000000981:diagnostic imaging; D004562:Electrocardiography / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D062211:Spatio-Temporal Analysis; D014672:Vectorcardiography / Q000379:methods*