title: Prevalence of autonomic dysfunction in hospitalized patients with Guillain-Barré syndrome.
abstract: There is a paucity of data regarding autonomic dysfunction (AD) in Guillain-Barré Syndrome (GBS). Concern exists regarding inpatient mortality risk in GBS. We sought to identify the prevalence of AD in GBS inpatients.
  
  
  
  We used the Health Cost and Utilization Project Nationwide Inpatient Sample (NIS). GBS hospitalizations were identified by International Classification of Diseases, Ninth Revision, Clinical Modification code-357.0. Non-GBS hospitalizations were matched to these cases 4:1 by age and gender.
  
  
  
  We identified 2,587 GBS patients and a control population of 10,348 patients during 2010-2011. The most common manifestations of AD were: diarrhea/constipation (15.5%), hyponatremia (14.9%), syndrome of inappropriate antidiuretic hormone secretion (SIADH) (4.8%), bradycardia (4.7%), and urinary retention (3.9%). GBS patients had higher rates of reversible cardiomyopathy, syncope, tachycardia, and Horner syndrome (P < 0.0001).
  
  
  
  AD most commonly manifests as diarrhea/constipation, SIADH/hyponatremia, and cardiac dysfunction. This report can help increase awareness of AD in GBS and aid in early identification, treatment, and mortality reduction. Muscle Nerve 56: 331-333, 2017.
authors.affiliation: Department of Neurology University of Toledo College of Medicine, 3000 Arlington Avenue, Toledo, Ohio, 43614, USA.
authors.forename: Charenya
authors.initials: C
authors.lastname: Anandan
authors.affiliation: Department of Medicine, University of Toledo College of Medicine, Toledo, Ohio, USA.
authors.forename: Sadik A
authors.initials: SA
authors.lastname: Khuder
authors.affiliation: Department of Neurology University of Toledo College of Medicine, 3000 Arlington Avenue, Toledo, Ohio, 43614, USA.
authors.forename: Boyd M
authors.initials: BM
authors.lastname: Koffman
mesh_terms: D001342:Autonomic Nervous System Diseases / Q000453:epidemiology* / Q000209:etiology*; D005260:Female; D020275:Guillain-Barre Syndrome / Q000150:complications* / Q000453:epidemiology*; D017048:Health Care Costs; D006760:Hospitalization; D006801:Humans; D038801:International Classification of Diseases; D008297:Male; D015995:Prevalence; D012189:Retrospective Studies
keywords: Guillain-Barré syndrome; Nationwide Inpatient Sample; SIADH; acute inflammatory demyelinating polyradiculoneuropathy; autonomic dysfunction; prevalence