title: Double Jeopardy: The Rubber Ball Bounces Twice.
abstract: Soblet et al. describe cis mutations in TEK/Tie-2 in blue rubber bleb nevus and sporadic vascular malformations. This suggests that the remaining normal allele is required for the phenotype. Second, it suggests therapeutic approaches to treatment signal transduction inhibition.
authors.affiliation: Department of Dermatology, Emory University School of Medicine, Atlanta Veterans Administration Medical Center, Winship Cancer Institute, Atlanta, Georgia, USA. Electronic address: jarbise@emory.edu.
authors.forename: Jack L
authors.initials: JL
authors.lastname: Arbiser
authors.affiliation: Department of Dermatology, Emory University School of Medicine, Atlanta Veterans Administration Medical Center, Winship Cancer Institute, Atlanta, Georgia, USA.
authors.forename: Linda C
authors.initials: LC
authors.lastname: Gilbert
mesh_terms: D000328:Adult; D000483:Alleles; D005770:Gastrointestinal Neoplasms / Q000235:genetics* / Q000473:pathology; D018324:Hemangioma, Capillary / Q000235:genetics / Q000473:pathology; D006801:Humans; D007223:Infant; D008868:Microtubule Proteins / Q000235:genetics*; D009154:Mutation; D018329:Nevus, Blue / Q000235:genetics* / Q000473:pathology; D010641:Phenotype; D012680:Sensitivity and Specificity; D012878:Skin Neoplasms / Q000235:genetics* / Q000473:pathology; D050826:Suppressor of Cytokine Signaling Proteins / Q000235:genetics*
chemical_list: D008868:Microtubule Proteins; D050826:Suppressor of Cytokine Signaling Proteins; C044103:tektins