title: Innate immune regulation of autoimmunity in multiple sclerosis: Focus on the role of Toll-like receptor 2.
abstract: Innate immunity relies on a set of germline-encoded receptors including Toll-like receptors (TLRs) that enable the host to discriminate between self and non-self. Multiple sclerosis (MS) is an autoimmune inflammatory demyelinating disease of the central nervous system (CNS). Infections are thought to play an important role in disease susceptibility. The role of innate immunity in MS has been recently appreciated. TLR2, a member of the TLR family, forms heterodimers with either TLR1 or TLR6 and detects a wide range of microbial as well as self-derived molecular structures. It may thus be important both in fighting infection and in activating autoimmunity. In this review, we discuss innate regulation of autoimmunity in MS with a focus on the role of TLR2 signaling.
authors.affiliation: Division of Clinical Neuroscience, University of Nottingham, School of Medicine, Queen's Medical Centre, Nottingham NG7 2UH, United Kingdom.
authors.forename: Md Jakir
authors.initials: MJ
authors.lastname: Hossain
authors.affiliation: Division of Clinical Neuroscience, University of Nottingham, School of Medicine, Queen's Medical Centre, Nottingham NG7 2UH, United Kingdom; Department of Neurology, Neurosurgery and Psychiatry, University of Medicine and Pharmacy Carol Davila, Colentina Hospital, Bucharest, Romania.
authors.forename: Radu
authors.initials: R
authors.lastname: Tanasescu
authors.affiliation: Division of Clinical Neuroscience, University of Nottingham, School of Medicine, Queen's Medical Centre, Nottingham NG7 2UH, United Kingdom; Department of Neurology, Nottingham University Hospitals NHS Trust, Nottingham NG7 2UH, United Kingdom. Electronic address: bruno.gran@nuh.nhs.uk.
authors.forename: Bruno
authors.initials: B
authors.lastname: Gran
mesh_terms: D000818:Animals; D015551:Autoimmunity / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D007155:Immunologic Factors / Q000276:immunology; D009103:Multiple Sclerosis / Q000276:immunology* / Q000473:pathology; D015398:Signal Transduction / Q000276:immunology; D051195:Toll-Like Receptor 2 / Q000502:physiology*
chemical_list: D007155:Immunologic Factors; D051195:Toll-Like Receptor 2
keywords: Autoimmunity; Inflammation; Innate immunity; Multiple sclerosis; Toll-like receptor 2