title: Angiogenesis and pro-angiogenic factors in uterine fibroids - facts and myths.
abstract: Uterine leiomyomata present major problem for females. Although they are benign tumors their frequency is associated with many symptoms like infertility, abdominal pain, menorrhagia. Authors based on their own morphological studies and review of the literature try to indicate main factors causing angiogenesis within leiomyomata and its influence on tumor growth. The strongest proangiogenic factor seems to be hypoxia, which stimulates up- and down-regulation of numerous genetically determined substances. Also mechanical pressure acting upon newly growing vessels is one of the factors which may determine formation of so called "vascular pseudocapsule" around the lesion.
authors.affiliation: Department of Anatomy, Jagiellonian University Medical College, Kraków, Poland.
authors.forename: Monika
authors.initials: M
authors.lastname: Konarska
authors.forename: Anna Natalia
authors.initials: AN
authors.lastname: Wrona
authors.forename: Veronika
authors.initials: V
authors.lastname: Aleksandrovych
authors.affiliation: Department of Anatomy, Jagiellonian University Medical College, Kraków, Poland. t.bereza@wp.pl.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Bereza
authors.forename: Marek
authors.initials: M
authors.lastname: Sajewicz
authors.forename: Barbara
authors.initials: B
authors.lastname: Gach-Kuniewicz
authors.forename: Maciej
authors.initials: M
authors.lastname: Lis
authors.forename: Kinga
authors.initials: K
authors.lastname: Komnata
authors.forename: Mateusz
authors.initials: M
authors.lastname: Paziewski
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Maleszka
authors.forename: Paweł
authors.initials: P
authors.lastname: Depukat
authors.forename: Bernard
authors.initials: B
authors.lastname: Solewski
authors.forename: Łukasz
authors.initials: Ł
authors.lastname: Warchoł
mesh_terms: D043925:Angiogenesis Inducing Agents / Q000378:metabolism*; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D007889:Leiomyoma / Q000098:blood supply*; D009215:Myometrium / Q000098:blood supply*; D009389:Neovascularization, Pathologic; D014594:Uterine Neoplasms / Q000098:blood supply*; D014599:Uterus / Q000098:blood supply*; D042442:Vascular Endothelial Growth Factors / Q000378:metabolism
chemical_list: D043925:Angiogenesis Inducing Agents; D036341:Intercellular Signaling Peptides and Proteins; D042442:Vascular Endothelial Growth Factors
keywords: angiogenesis; microvessel density; uterine leiomyomata