title: [Guide to clinical practice for the diagnosis, treatment and rehabilitation of non-syndromic craniosynostosis on 3 levels of care].
abstract: BACKGROUND
  Craniosynostosis is a congenital anomaly resulting from the premature fusion of the cranial sutures changing growth patterns of the skull.
  
  
  METHODS
  Focus, scope, target population and clinical questions to be solved were defined. A systematic search for evidence in different databases (Medline, Embase, KoreaMed, Cochrane Library and the website of the World Health Organization) in stages was performed: clinical practice guidelines; systematic reviews, and clinical trials and observational studies; using MeSH, Decs and corresponding free terms, unrestricted language or temporality. Risk of bias was evaluated using appropriate tools (AMSTAR, Risk of Bias or STROBE). The quality of evidence was graduated using the GRADE system. Modified Delphi Panel technique was used to assign the recommendation's strength and direction, as well as the degree of agreement with it, taking into account the quality of evidence, balance between risks and benefits of interventions, values and preferences of patients and availability of resources.
  
  
  RESULTS
  There were 3,712 documents obtained by search algorithms; selecting 29 documents for inclusion in the qualitative synthesis. Due to heterogeneity between studies, it was not possible to perform meta-analysis.
  
  
  CONCLUSIONS
  We issued 7 recommendations and 8 good practice points, which will serve as support for decision-making in the comprehensive care of patients with craniosynostosis.
authors.affiliation: Genética, Centro de Rehabilitación e Inclusión Infantil Teletón Puebla, San Andrés Cholula, México.
authors.forename: Dulce María
authors.initials: DM
authors.lastname: Castro Coyotl
authors.affiliation: Medicina Física y Rehabilitación, Centro de Rehabilitación e Inclusión Infantil Teletón Puebla, San Andrés Cholula, México.
authors.forename: Xanath Olivia
authors.initials: XO
authors.lastname: Rosas Huerta
authors.affiliation: Medicina Física y Rehabilitación, Centro de Rehabilitación e Inclusión Infantil Teletón Puebla, San Andrés Cholula, México.
authors.forename: José Juan
authors.initials: JJ
authors.lastname: Sánchez Vázquez
authors.affiliation: Medicina Física y Rehabilitación, Centro de Rehabilitación e Inclusión Infantil Teletón Puebla, San Andrés Cholula, México.
authors.forename: Margarita Isabel
authors.initials: MI
authors.lastname: Díaz Sánchez
authors.affiliation: Neurocirugía, Hospital para el Niño Poblano, San Andrés Cholula, México.
authors.forename: José Salvador
authors.initials: JS
authors.lastname: Rodríguez Peralta
authors.affiliation: Coordinación de Investigación, Hospital General de Puebla Dr. Eduardo Vázquez Navarro, Puebla, México.
authors.forename: Juan Manuel
authors.initials: JM
authors.lastname: Tetitla Munive
authors.affiliation: Medicina Física y Rehabilitación, Hospital General de Puebla Dr. Eduardo Vázquez Navarro, Puebla, México.
authors.forename: María de Lourdes
authors.initials: ML
authors.lastname: Peralta Porras
authors.affiliation: Pediatría, Hospital para el Niño Poblano, San Andrés Cholula, México.
authors.forename: Alejandra Janeth
authors.initials: AJ
authors.lastname: Arellano Cruz
authors.affiliation: Dirección de Integración de Guías de Práctica Clínica, Centro Nacional de Excelencia Tecnológica en Salud (CENETEC), Ciudad de México, México.
authors.forename: Jesús Ojino
authors.initials: JO
authors.lastname: Sosa García
authors.affiliation: Coordinación de Guías de Práctica Clínica, Centro Nacional de Excelencia Tecnológica en Salud (CENETEC), Ciudad de México, México. Electronic address: christianfareligonzalez@gmail.com.
authors.forename: Christian Javier
authors.initials: CJ
authors.lastname: Fareli González
mesh_terms: D002986:Clinical Trials as Topic; D003398:Craniosynostoses / Q000175:diagnosis / Q000534:rehabilitation / Q000601:surgery; D003697:Delphi Technique; D019317:Evidence-Based Medicine; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D064887:Observational Studies as Topic; D017410:Practice Guidelines as Topic; D012189:Retrospective Studies; D012307:Risk Factors
keywords: Clinical practice guideline; Craneosinostosis; Craniosynostoses; Guideline; Guía; Guía de práctica clínica