title: Two new compounds from the seeds of Vernonia anthelmintica.
abstract: Two new compounds, named benzoyl-vernovan (1) and 2-(4'-hydroxyphenyl)-6-methyl-4H-pyran-4-one (2), together with one biflavonoid (3), one aurone (4) and six flavonoids were isolated from the seeds of Vernonia anthelmintica. Their structures were elucidated by extensive spectroscopic analyses and comparison with published data, and their influence on melanin content in B16 melanoma cells were tested. 5 and 9 increased melanin content by 2.2% and 30.9% higher than positive control 8-methoxypsoralen.
authors.affiliation: a State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization , Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , Urumqi 830011 , China.|b University of the Chinese Academy of Sciences , Beijing 100039 , China.
authors.forename: Zulipiya
authors.initials: Z
authors.lastname: Maimaiti
authors.affiliation: a State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization , Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , Urumqi 830011 , China.
authors.forename: Ablajan
authors.initials: A
authors.lastname: Turak
authors.affiliation: a State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization , Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , Urumqi 830011 , China.
authors.forename: Haji Akber
authors.initials: HA
authors.lastname: Aisa
mesh_terms: D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000302:isolation & purification* / Q000494:pharmacology; D008543:Melanins / Q000032:analysis; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012639:Seeds / Q000737:chemistry*; D035741:Vernonia / Q000737:chemistry*
chemical_list: C000622333:2-(4'-hydroxyphenyl)-6-methyl-4H-pyran-4-one; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D006027:Glycosides; D008543:Melanins; D011753:Pyrones; C000622332:benzoyl-vernovan
keywords: B16 melanoma cells; Compositae; Vernonia anthelmintica; flavonoids; melanin content