title: Manic espisode, confusional syndrome and reversible splenial lesion after abrupt withdrawal of oxcarbazepine.
abstract: Anticonvulsants are considered a second line option for bipolar disorder, it is known that the abrupt withdrawal is rarely related with demyelinated lesions of the splenium of the corpus callosum. Oxcarbazepine is used in bipolar disorder although it is not stated in the data sheet.
  
  
  
  We presented a case of a 50 years old woman with bipolar disorder who is treated with lithium and oxcarbazepine, she presented a manic episode and a confusional syndrome after she stopped taking the medication. The magnetic resonance showed a restricted diffusion area at the splenium of the corpus callosum and bifrontal hygromas that disappear two weeks later.
  
  
  
  The results of this study suggest that for a patient presenting with a mild encephalopathy and reversible splenial lesion, one should consider whether it is related to withdrawal of oxcarbazepine.
authors.affiliation: "La Fe" Hospital, Valencia, Spain. Electronic address: mmerizaldet@hotmail.com.
authors.forename: Milton
authors.initials: M
authors.lastname: Merizalde
authors.affiliation: "La Fe" Hospital, Valencia, Spain.
authors.forename: Pablo
authors.initials: P
authors.lastname: Navalón
authors.affiliation: "La Fe" Hospital, Valencia, Spain.
authors.forename: María Fernanda
authors.initials: MF
authors.lastname: González
authors.affiliation: "La Fe" Hospital, Valencia, Spain.
authors.forename: Alberto
authors.initials: A
authors.lastname: Domínguez
authors.affiliation: "La Fe" Hospital, Valencia, Spain.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Livianos
authors.affiliation: "La Fe" Hospital, Valencia, Spain.
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Martínez
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000150:complications / Q000188:drug therapy / Q000209:etiology* / Q000523:psychology; D002220:Carbamazepine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003221:Confusion / Q000209:etiology* / Q000523:psychology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D000078330:Oxcarbazepine; D013158:Splenic Diseases / Q000000981:diagnostic imaging / Q000209:etiology*; D013375:Substance Withdrawal Syndrome / Q000150:complications* / Q000523:psychology*
chemical_list: D000927:Anticonvulsants; D002220:Carbamazepine; D000078330:Oxcarbazepine
keywords: Bipolar disease; Encephalopathy; Manic episode; Oxcarbazepine