title: In vivo study of viral haemorrhagic septicaemia virus and infectious pancreatic necrosis virus coexistence in Senegalese sole (Solea senegalensis).
abstract: The effect of IPNV-VHSV coinfection and superinfection on the mortality caused by both viruses in Senegalese sole has been analysed. No effect was observed after coinfection. However, a clear viral interference was recorded between a primary IPNV and a subsequent VHSV infection, which led to a survival increase in the infected sole of 50% points when compared with fish infected only with VHSV. The significantly higher Mx transcriptional values in the fish pre-exposed to IPNV (at least at first days after superinfection) and the increased daily mortality when low Mx transcriptional levels were recorded suggest that Mx may be involved in the protective effect against VHSV infection. However, in fish subjected to VHSV primary/IPNV secondary infection, no interference was observed.
authors.affiliation: Departamento de Microbiología y Parasitología, Instituto de Acuicultura, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
authors.forename: C
authors.initials: C
authors.lastname: López-Vázquez
authors.affiliation: Universidad de Málaga, Departamento de Microbiología, Facultad de Ciencias, Málaga, Spain.
authors.forename: M C
authors.initials: MC
authors.lastname: Alonso
authors.affiliation: Departamento de Microbiología y Parasitología, Instituto de Acuicultura, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
authors.forename: C P
authors.initials: CP
authors.lastname: Dopazo
authors.affiliation: Departamento de Microbiología y Parasitología, Instituto de Acuicultura, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
authors.forename: I
authors.identifier: http://orcid.org/0000-0002-1947-5933
authors.initials: I
authors.lastname: Bandín
mesh_terms: D000818:Animals; D018175:Birnaviridae Infections / Q000401:mortality / Q000662:veterinary* / Q000821:virology; D060085:Coinfection / Q000401:mortality / Q000662:veterinary* / Q000821:virology; D005393:Fish Diseases / Q000401:mortality* / Q000821:virology; D029941:Fish Proteins / Q000276:immunology; D005412:Flatfishes; D031941:Hemorrhagic Septicemia, Viral / Q000401:mortality* / Q000821:virology; D018061:Infectious pancreatic necrosis virus / Q000502:physiology; D007372:Interferons / Q000276:immunology; D029141:Novirhabdovirus / Q000502:physiology; D015163:Superinfection / Q000401:mortality / Q000662:veterinary* / Q000821:virology
chemical_list: D029941:Fish Proteins; D007372:Interferons
keywords: 
  Solea senegalensis
  ; Mx; infectious pancreatic necrosis virus; viral haemorrhagic septicaemia virus; viral interference