title: Serum vaspin levels and carotid intima media thickness in pre dialysis patients.
abstract: OBJECTIVE
  Vaspin is a molecule belonging to adipokine family which is associated with insulin resistance and obesity in humans. Several studies have evaluated the serum levels of vaspin in various conditions including coronary artery disease and chronic hemodialysis patients. To our best knowledge, serum vaspin levels have not yet been studied in pre dialysis patients. Carotid intima-media thickness (CIMT) is a noninvasive procedure used to diagnose the extent of carotid atherosclerotic vascular disease. The objective of this study is to evaluate serum vaspin levels in pre dialysis patients and their relationships with glomerular filtration rate and CIMT levels.
  
  
  METHODS
  A total of twenty-five pre dialysis patients (14 female and 11 male) and 22 healthy controls (8 female and 14 male) were included in the study. CIMT was measured through B-mode ultrasonography.
  
  
  RESULTS
  Serum vaspin levels were significantly lower (p<0.05) and CIMT levels were significantly higher (p<0.001) in pre dialysis patients than in control subjects. Serum vaspin levels were found to be significantly correlated with glomerular filtration rate (r=0.42, p<0.001) and CIMT (r=-0.47, p<0.05) in pre dialysis patients.
  
  
  CONCLUSIONS
  This is the first report to describe the correlation between serum vaspin levels and CIMT in pre dialysis patients. We concluded that serum vaspin levels were decreased in pre dialysis patients compared to the control subjects. In addition, serum vaspin levels were found to be significantly correlated with glomerular filtration rate and CIMT. This article is protected by copyright. All rights reserved.
authors.affiliation: Yuzuncu Yil University, Faculty of Medicine, Department of Cardiology, Van, Turkey.
authors.forename: Aytac
authors.initials: A
authors.lastname: Akyol
authors.affiliation: Yuzuncu Yil University, Faculty of Medicine, Department of Internal Medicine, Van, Turkey.
authors.forename: Davut
authors.initials: D
authors.lastname: Demirkıran
authors.forename: Serkan
authors.initials: S
authors.lastname: Akdag
authors.affiliation: Yuzuncu Yil University, Faculty of Medicine, Department of Internal Medicine, Van, Turkey.
authors.forename: Mehmet Naci
authors.initials: MN
authors.lastname: Aldemir
authors.forename: Hakkı
authors.initials: H
authors.lastname: Simsek
authors.forename: Hasan Ali
authors.initials: HA
authors.lastname: Gumrukcuoglu
authors.forename: Musa
authors.initials: M
authors.lastname: Sahin
authors.affiliation: Yuzuncu Yil University, Faculty of Medicine, Department of Nephrology, Van, Turkey.
authors.forename: Habib
authors.initials: H
authors.lastname: Emre
keywords: Vaspin; carotid intima media thickness; chronic kidney disease; glomerular filtration rate