title: Relationship between two blood stasis syndromes and inflammatory factors in patients with acute coronary syndrome.
abstract: OBJECTIVE
  To investigate the relationship between inflammatory factors and two Chinese medicine (CM) syndrome types of qi stagnation and blood stasis (QSBS) and qi deficiency and blood stasis (QDBS) in patients with acute coronary syndrome (ACS).
  
  
  METHODS
  Sixty subjects with ACS, whose pathogenesis changes belongs to qi disturbance blood stasis syndrome, were divided into 2 groups: 30 in the QSBS group and 30 in the QDBS group. The comparative analysis on them was carried out through comparing general information, coronary angiography and inflammatory factors including intracellular adhesion molecule-1 (ICAM-1), chitinase-3-like protein 1 (YKL-40) and lipoprotein-associated phospholipase A2 (Lp-PLA2).
  
  
  RESULTS
  Compared with the QSBS group, Lp-PLA2 and YKL-40 levels in the QDBS group showed no-significant difference (P>0.05); ICAM-1 was significantly higher in the QDBS group than in the QSBS group in the pathological processes of qi disturbance and blood stasis syndrome of ACS (P<0.05).
  
  
  CONCLUSIONS
  Inflammatory factor ICAM-1 may be an objective basis for syndrome typing of QSBS and QDBS, which provides a research direction for standardization research of CM syndrome types.
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, 100029, China.|Department of Cardiology, Aviation General Hospital, Beijing, 100016, China.
authors.forename: Cai-Yun
authors.initials: CY
authors.lastname: Ma
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, 100029, China. liujinghua@vip.sina.com.
authors.forename: Jing-Hua
authors.initials: JH
authors.lastname: Liu
authors.affiliation: Institute of Basic Medical Sciences, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China. liujx0324@sina.com.
authors.forename: Jian-Xun
authors.initials: JX
authors.lastname: Liu
authors.affiliation: Cardiovascular Diseases Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China.
authors.forename: Da-Zhuo
authors.initials: DZ
authors.lastname: Shi
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, 100029, China.
authors.forename: Zhen-Ye
authors.initials: ZY
authors.lastname: Xu
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, 100029, China.
authors.forename: Shao-Ping
authors.initials: SP
authors.lastname: Wang
authors.affiliation: Cardiovascular Diseases Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China.
authors.forename: Min
authors.initials: M
authors.lastname: Jia
authors.affiliation: Cardiovascular Diseases Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China.
authors.forename: Fu-Hai
authors.initials: FH
authors.lastname: Zhao
authors.affiliation: Cardiovascular Diseases Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China.
authors.forename: Yue-Rong
authors.initials: YR
authors.lastname: Jiang
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, 100029, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Ma
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, 100029, China.
authors.forename: Hong-Yu
authors.initials: HY
authors.lastname: Peng
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, 100029, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, 100029, China.
authors.forename: Ze
authors.initials: Z
authors.lastname: Zheng
authors.affiliation: Department of Cardiology, Aviation General Hospital, Beijing, 100016, China.
authors.forename: Feng-Xue
authors.initials: FX
authors.lastname: Ren
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood* / Q000000981:diagnostic imaging; D017023:Coronary Angiography; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood*; D018836:Inflammation Mediators / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D013577:Syndrome
chemical_list: D018836:Inflammation Mediators
keywords: Chinese medicine; chitinase-3-like protein 1; coronary heart disease; inflammation; intracellular adhesion molecule-1; lipoprotein-associated phospholipase A2; qi deficiency and blood stasis syndrome; qi stagnation and blood stasis syndrome