title: ACKR2: Nature's Decoy Receptor Lures Unsuspecting Chemokines in Psoriasis.
abstract: While we know much about the processes mediated by the Th17 inflammatory pathway that is crucial in psoriasis, we actually know little about the processes by which most psoriatic patients maintain what grossly looks like non-inflamed, normal skin in the face of massive inflammatory changes in nearby affected skin. Other molecular regulators that defend the skin from global inflammation are likely to be involved, including molecules such as ACKR2, an atypical chemokine receptor whose role in psoriasiform dermatitis is explored by Shams et al.
authors.affiliation: Department of Dermatology, Tokai University School of Medicine, Kanagawa, Japan.
authors.forename: Tomotaka
authors.initials: T
authors.lastname: Mabuchi
authors.affiliation: Department of Dermatology, University of California-Davis, Sacramento, California, USA. Electronic address: sthwang@ucdavis.edu.
authors.forename: Samuel T
authors.initials: ST
authors.lastname: Hwang
mesh_terms: D000818:Animals; D018450:Disease Progression; D005786:Gene Expression Regulation; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000276:immunology; D051379:Mice; D011565:Psoriasis / Q000235:genetics* / Q000276:immunology* / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics; D019707:Receptors, Chemokine / Q000235:genetics* / Q000276:immunology; D012016:Reference Values; D012720:Severity of Illness Index; D015398:Signal Transduction; D058504:Th17 Cells / Q000276:immunology*; D000097628:Chemokine Receptor D6
chemical_list: D012333:RNA, Messenger; D019707:Receptors, Chemokine; C515708:ACKR2 protein, human; D000097628:Chemokine Receptor D6