title: The control of DNA repair by the cell cycle.
abstract: The correct duplication and transmission of genetic material to daughter cells is the primary objective of the cell division cycle. DNA replication and chromosome segregation present both challenges and opportunities for DNA repair pathways that safeguard genetic information. As a consequence, there is a profound, two-way connection between DNA repair and cell cycle control. Here, we review how DNA repair processes, and DNA double-strand break repair in particular, are regulated during the cell cycle to optimize genomic integrity.
authors.affiliation: Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada.
authors.forename: Nicole
authors.initials: N
authors.lastname: Hustedt
authors.affiliation: Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada.|Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5S 3E1, Canada.
authors.forename: Daniel
authors.identifier: http://orcid.org/0000-0003-3863-8635
authors.initials: D
authors.lastname: Durocher
mesh_terms: D000818:Animals; D002453:Cell Cycle; D002875:Chromosomes / Q000378:metabolism; D053903:DNA Breaks, Double-Stranded; D004260:DNA Repair; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism; D059765:Homologous Recombination / Q000235:genetics; D006801:Humans; D009097:Multienzyme Complexes / Q000378:metabolism; D000099272:Replisomes
chemical_list: D004259:DNA-Directed DNA Polymerase; D009097:Multienzyme Complexes; D000099272:Replisomes