title: One-day postoperative intraocular pressure spikes after phacoemulsification cataract surgery in patients taking tamsulosin.
abstract: To evaluate the relationship between 1-day postoperative intraocular pressure (IOP) after phacoemulsification cataract surgery and tamsulosin use.
  
  
  
  University of Colorado Health Eye Center, Aurora, Colorado, USA.
  
  
  
  Retrospective cohort study.
  
  
  
  Registry data from men who had cataract surgery were used. Patients taking tamsulosin at the time of surgery were included as cases, while patients with no history of tamsulosin use were used as controls. The primary outcome was a 1-day postoperative IOP spike defined as an IOP increase greater than 10 mm Hg compared with baseline or a 1-day postoperative IOP of 30 mm Hg or higher. General estimating equations were used for analysis.
  
  
  
  The study comprised 584 men (864 eyes). An IOP increase greater than 10 mm Hg or IOP 30 mm Hg or higher after cataract surgery occurred in 12.4% and 9.3%, respectively, of eyes in the tamsulosin group versus 4.4% and 2.1%, respectively, in the control group (all P = .001). After adjusting for significant covariates, patients on tamsulosin were 2.6 times (95% confidence interval [CI], 1.2-5.7; P = .01] and 3.8 (95% CI, 1.3-10.9; P = .01) more likely to have a 1-day postoperative IOP increase greater than 10 mm Hg or a 1-day postoperative IOP of 30 mm Hg or higher.
  
  
  
  Patients on tamsulosin had an increased risk of a 1-day postoperative IOP spike after cataract surgery, showing the importance of identifying patients on tamsulosin preoperatively to better manage and potentially mitigate IOP spikes.
  
  
  
  None of the authors has a financial or proprietary interest in any material or method mentioned.
authors.affiliation: From the Department of Ophthalmology (Bonnell, SooHoo, Seibold, Lynch, Davidson, Taravella), University of Colorado School of Medicine, and the Department of Biostatistics & Informatics (Wagner), Colorado School of Public Health, Aurora, Colorado, USA. Electronic address: levi.bonnell@ucdenver.edu.
authors.forename: Levi N
authors.initials: LN
authors.lastname: Bonnell
authors.affiliation: From the Department of Ophthalmology (Bonnell, SooHoo, Seibold, Lynch, Davidson, Taravella), University of Colorado School of Medicine, and the Department of Biostatistics & Informatics (Wagner), Colorado School of Public Health, Aurora, Colorado, USA.
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: SooHoo
authors.affiliation: From the Department of Ophthalmology (Bonnell, SooHoo, Seibold, Lynch, Davidson, Taravella), University of Colorado School of Medicine, and the Department of Biostatistics & Informatics (Wagner), Colorado School of Public Health, Aurora, Colorado, USA.
authors.forename: Leonard K
authors.initials: LK
authors.lastname: Seibold
authors.affiliation: From the Department of Ophthalmology (Bonnell, SooHoo, Seibold, Lynch, Davidson, Taravella), University of Colorado School of Medicine, and the Department of Biostatistics & Informatics (Wagner), Colorado School of Public Health, Aurora, Colorado, USA.
authors.forename: Anne M
authors.initials: AM
authors.lastname: Lynch
authors.affiliation: From the Department of Ophthalmology (Bonnell, SooHoo, Seibold, Lynch, Davidson, Taravella), University of Colorado School of Medicine, and the Department of Biostatistics & Informatics (Wagner), Colorado School of Public Health, Aurora, Colorado, USA.
authors.forename: Brandie D
authors.initials: BD
authors.lastname: Wagner
authors.affiliation: From the Department of Ophthalmology (Bonnell, SooHoo, Seibold, Lynch, Davidson, Taravella), University of Colorado School of Medicine, and the Department of Biostatistics & Informatics (Wagner), Colorado School of Public Health, Aurora, Colorado, USA.
authors.forename: Richard S
authors.initials: RS
authors.lastname: Davidson
authors.affiliation: From the Department of Ophthalmology (Bonnell, SooHoo, Seibold, Lynch, Davidson, Taravella), University of Colorado School of Medicine, and the Department of Biostatistics & Informatics (Wagner), Colorado School of Public Health, Aurora, Colorado, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Taravella
mesh_terms: D058668:Adrenergic alpha-1 Receptor Antagonists / Q000627:therapeutic use*; D002386:Cataract; D002387:Cataract Extraction; D006801:Humans; D007429:Intraocular Pressure; D019654:Lens Implantation, Intraocular; D008297:Male; D018918:Phacoemulsification; D012189:Retrospective Studies; D013449:Sulfonamides / Q000627:therapeutic use*; D000077409:Tamsulosin
chemical_list: D058668:Adrenergic alpha-1 Receptor Antagonists; D013449:Sulfonamides; D000077409:Tamsulosin