title: The Effects of High-Concentration Oxygen on Inflammatory Markers in Laparoscopic Cholecystectomy: A Randomized Controlled Trial.
abstract: BACKGROUND
  This study assessed effect of administration of high-concentration supplemental perioperative oxygen on systemic inflammatory and immune response in patients undergoing elective laparoscopic cholecystectomy.
  
  
  METHODS
  One hundred seventy-seven patients were assigned randomly to an oxygen/air mixture with a fraction of inspired oxygen (FiO2) of 30% (n=88) or 80% (n=89). White blood cells, peripheral lymphocytes subpopulation, human leukocyte antigen-DR, neutrophil elastase, interleukin (IL)-1 and IL-6, and C-reactive protein were investigated.
  
  
  RESULTS
  Significantly higher concentration of neutrophil elastase, IL-1, IL-6 and C-reactive protein was detected postoperatively in the 30% FiO2 group patients in comparison with the 80% FiO2 group (P<0.05). Statistically significant change in human leukocyte antigen-DR expression was recorded postoperatively at 24 hours, as a reduction of this antigen expressed on monocyte surface in patients from 30% FiO2 group.
  
  
  CONCLUSIONS
  This study demonstrated that high-concentration (80%) supplemental perioperative oxygen can lead to a reduction in postoperative inflammatory response and avoid postoperative immunosuppression.
authors.affiliation: Department of Surgery, University of L'Aquila, L'Aquila, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Schietroma
authors.forename: Sara
authors.initials: S
authors.lastname: Colozzi
authors.forename: Beatrice
authors.initials: B
authors.lastname: Pessia
authors.forename: Francesco
authors.initials: F
authors.lastname: Carlei
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Amicucci
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D016063:Blood Loss, Surgical; D002097:C-Reactive Protein / Q000378:metabolism; D017081:Cholecystectomy, Laparoscopic / Q000379:methods*; D005260:Female; D042882:Gallstones / Q000601:surgery*; D006801:Humans; D007375:Interleukin-1 / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D007958:Leukocyte Count; D019272:Leukocyte Elastase / Q000378:metabolism; D016131:Lymphocyte Subsets / Q000502:physiology; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000008:administration & dosage* / Q000097:blood; D010313:Partial Pressure; D011300:Preoperative Care; D011446:Prospective Studies
chemical_list: D015415:Biomarkers; D007375:Interleukin-1; D015850:Interleukin-6; D002097:C-Reactive Protein; D019272:Leukocyte Elastase; D010100:Oxygen