title: The ReACT Trial: Randomized Evaluation of Routine Follow-up Coronary Angiography After Percutaneous Coronary Intervention Trial.
abstract: The purpose of this study was to evaluate long-term clinical impact of routine follow-up coronary angiography (FUCAG) after percutaneous coronary intervention (PCI) in daily clinical practice in Japan.
  
  
  
  The long-term clinical impact of routine FUCAG after PCI in real-world clinical practice has not been evaluated adequately.
  
  
  
  In this prospective, multicenter, open-label, randomized trial, patients who underwent successful PCI were randomly assigned to routine angiographic follow-up (AF) group, in which patients were to receive FUCAG at 8 to 12 months after PCI, or clinical follow-up alone (CF) group. The primary endpoint was defined as a composite of death, myocardial infarction, stroke, emergency hospitalization for acute coronary syndrome, or hospitalization for heart failure over a minimum of 1.5 years follow-up.
  
  
  
  Between May 2010 and July 2014, 700 patients were enrolled in the trial among 22 participating centers and were randomly assigned to the AF group (n = 349) or the CF group (n = 351). During a median of 4.6 years of follow-up (interquartile range [IQR]: 3.1 to 5.2 years), the cumulative 5-year incidence of the primary endpoint was 22.4% in the AF group and 24.7% in the CF group (hazard ratio: 0.94; 95% confidence interval: 0.67 to 1.31; p = 0.70). Any coronary revascularization within the first year was more frequently performed in AF group than in CF group (12.8% vs. 3.8%; log-rank p < 0.001), although the difference between the 2 groups attenuated over time with a similar cumulative 5-year incidence (19.6% vs. 18.1%; log-rank p = 0.92).
  
  
  
  No clinical benefits were observed for routine FUCAG after PCI and early coronary revascularization rates were increased within routine FUCAG strategy in the current trial. (Randomized Evaluation of Routine Follow-up Coronary Angiography After Percutaneous Coronary Intervention Trial [ReACT]; NCT01123291).
authors.affiliation: Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Shiomi
authors.affiliation: Department of Clinical Epidemiology, Hyogo College of Medicine, Hyogo, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Morimoto
authors.affiliation: Division of Cardiology, Hirakata Kohsai Hospital, Hirakata, Japan.
authors.forename: Shoji
authors.initials: S
authors.lastname: Kitaguchi
authors.affiliation: Division of Cardiology, Tenri Hospital, Nara, Japan.
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Nakagawa
authors.affiliation: Division of Cardiology, Kansai Electric Power Hospital, Osaka, Japan.
authors.forename: Katsuhisa
authors.initials: K
authors.lastname: Ishii
authors.affiliation: Division of Cardiology, Hirakata Kohsai Hospital, Hirakata, Japan.
authors.forename: Yoshisumi
authors.initials: Y
authors.lastname: Haruna
authors.affiliation: Department of Cardiology, Sakakibara Heart Institute, Japan Research Promotion Society for Cardiovascular Diseases, Tokyo, Japan.
authors.forename: Itaru
authors.initials: I
authors.lastname: Takamisawa
authors.affiliation: Division of Cardiology, Shizuoka General Hospital, Shizuoka, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Motooka
authors.affiliation: Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Nakao
authors.affiliation: Division of Cardiology, Nishikobe Medical Center, Kobe, Japan.
authors.forename: Shintaro
authors.initials: S
authors.lastname: Matsuda
authors.affiliation: Department of Cardiology, New Tokyo Hospital, Tokyo, Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Mimoto
authors.affiliation: Department of Cardiology, Nagoya Second Red Cross Hospital, Nagoya, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Aoyama
authors.affiliation: Division of Cardiology, Koto Memorial Hospital, Higashioumi, Japan.
authors.forename: Teruki
authors.initials: T
authors.lastname: Takeda
authors.affiliation: Department of Cardiology, Shizuoka City Shizuoka Hospital, Shizuoka, Japan.
authors.forename: Koichiro
authors.initials: K
authors.lastname: Murata
authors.affiliation: Department of Cardiology, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
authors.forename: Masaharu
authors.initials: M
authors.lastname: Akao
authors.affiliation: Cardiovascular Center Osaka Red Cross Hospital, Osaka, Japan.
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Inada
authors.affiliation: Division of Cardiology, Nishikobe Medical Center, Kobe, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Eizawa
authors.affiliation: Department of Cardiology, Saiseikai Shimonoseki General Hospital, Yamaguchi, Japan.
authors.forename: Eiji
authors.initials: E
authors.lastname: Hyakuna
authors.affiliation: Department of Cardiology, Kitaharima Medical Center, Hyogo, Japan.
authors.forename: Kojiro
authors.initials: K
authors.lastname: Awano
authors.affiliation: Department of Cardiology, Kindai University Nara Hospital, Nara, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Shirotani
authors.affiliation: Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Furukawa
authors.affiliation: Division of Cardiology, Kurashiki Central Hospital, Kurashiki, Japan.
authors.forename: Kazushige
authors.initials: K
authors.lastname: Kadota
authors.affiliation: Department of Cardiovascular Medicine, Juntendo University, Graduate School of Medicine, Tokyo, Japan.
authors.forename: Katsumi
authors.initials: K
authors.lastname: Miyauchi
authors.affiliation: Cardiovascular Center Osaka Red Cross Hospital, Osaka, Japan.
authors.forename: Masaru
authors.initials: M
authors.lastname: Tanaka
authors.affiliation: Department of Cardiology, Tsukuba Medical Center Hospital, Tsukuba, Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Noguchi
authors.affiliation: Department of Cardiology, New Tokyo Hospital, Tokyo, Japan.
authors.forename: Sunao
authors.initials: S
authors.lastname: Nakamura
authors.affiliation: Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yasuda
authors.affiliation: Division of Cardiology, Kindai University, Osaka, Japan.
authors.forename: Shunichi
authors.initials: S
authors.lastname: Miyazaki
authors.affiliation: Department of Cardiovascular Medicine, Juntendo University, Graduate School of Medicine, Tokyo, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Daida
authors.affiliation: Division of Cardiology, Yokohama City University Medical Center, Yokohama, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kimura
authors.affiliation: Department of Cardiology, Tokai University, Kanagawa, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Ikari
authors.affiliation: Department of Cardiology, Nagoya Second Red Cross Hospital, Nagoya, Japan.
authors.forename: Haruo
authors.initials: H
authors.lastname: Hirayama
authors.affiliation: Department of Cardiology, Sakakibara Heart Institute, Japan Research Promotion Society for Cardiovascular Diseases, Tokyo, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Sumiyoshi
authors.affiliation: Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Japan. Electronic address: taketaka@kuhp.kyoto-u.ac.jp.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kimura
mesh_terms: D054058:Acute Coronary Syndrome / Q000209:etiology; D000368:Aged; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000150:complications / Q000000981:diagnostic imaging / Q000401:mortality / Q000628:therapy*; D003331:Coronary Vessels / Q000000981:diagnostic imaging*; D005260:Female; D006333:Heart Failure / Q000209:etiology; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000209:etiology; D010359:Patient Readmission; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects / Q000401:mortality; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012307:Risk Factors; D020521:Stroke / Q000209:etiology; D013997:Time Factors; D016896:Treatment Outcome
keywords: angiographic follow-up; percutaneous coronary intervention; prognosis; stent(s)