title: Antifouling Manganese Oxide Nanoparticles: Synthesis, Characterization, and Applications for Enhanced MR Imaging of Tumors.
abstract: Antifouling manganese oxide (Mn3O4) nanoparticles (NPs) were synthesized by solvothermal decomposition of tris(2,4-pentanedionato) manganese(III) in the presence of trisodium citrate, followed by surface modification with polyethylene glycol and l-cysteine. The as-prepared nanoparticles have a uniform size distribution, good colloidal stability and good cytocompatibility. The modification of l-cysteine rendered the particles with much longer blood circulation time (half-decay time of 28.4 h) than those without l-cysteine modification (18.5 h), and decreased macrophage cellular uptake. Thanks to desirable antifouling property and relatively high r1relaxivity (3.66 mM-1s-1), the l-cysteine-modified Mn3O4NPs can be used for enhanced tumor magnetic resonance imaging applications.
authors.affiliation: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University , Shanghai 201620, People's Republic of China.
authors.forename: Peng
authors.initials: P
authors.lastname: Wang
authors.affiliation: Department of Radiology, Department of Ultrasound, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University , Shanghai 200080, People's Republic of China.
authors.forename: Jia
authors.initials: J
authors.lastname: Yang
authors.affiliation: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University , Shanghai 201620, People's Republic of China.
authors.forename: Benqing
authors.initials: B
authors.lastname: Zhou
authors.affiliation: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University , Shanghai 201620, People's Republic of China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Department of Radiology, Department of Ultrasound, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University , Shanghai 200080, People's Republic of China.
authors.forename: Lingxi
authors.initials: L
authors.lastname: Xing
authors.affiliation: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University , Shanghai 201620, People's Republic of China.
authors.forename: Fanli
authors.initials: F
authors.lastname: Xu
authors.affiliation: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University , Shanghai 201620, People's Republic of China.
authors.forename: Mingwu
authors.initials: M
authors.lastname: Shen
authors.affiliation: Department of Radiology, Department of Ultrasound, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University , Shanghai 200080, People's Republic of China.
authors.forename: Guixiang
authors.initials: G
authors.lastname: Zhang
authors.affiliation: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University , Shanghai 201620, People's Republic of China.
authors.forename: Xiangyang
authors.identifier: 0000-0001-6785-6645
authors.initials: X
authors.lastname: Shi
mesh_terms: D003287:Contrast Media; D006801:Humans; D008279:Magnetic Resonance Imaging; D017895:Manganese Compounds; D053768:Metal Nanoparticles; D053758:Nanoparticles; D009369:Neoplasms; D010087:Oxides
chemical_list: D003287:Contrast Media; D017895:Manganese Compounds; D010087:Oxides; C027424:manganese oxide
keywords: antifouling; blood circulation time; l-cysteine; manganese oxide nanoparticles; tumor magnetic resonance imaging