title: Gut microbiota and allergy/asthma: From pathogenesis to new therapeutic strategies.
abstract: Asthma and atopy, classically associated with hyper-activation of the T helper 2 (Th2) arm of adaptive immunity, are among the most common chronic illnesses worldwide. Emerging evidence relates atopy and asthma to the composition and function of gut microbiota composition. Moreover, certain gut microbial strains have been shown to inhibit or attenuate immune responses associated with chronic inflammation in experimental models. Although still a relatively nascent field of research, evidence to date suggests that the gut microbiome may represent fertile targets for prevention or management of allergic asthma and other diseases in which adaptive immune dysfunction is a prominent feature. The oral probiotics/prebiotic represents a possible therapeutic for improving asthma and allergic disease. Especially, recent technological developments that permit identification of microbes and their products using culture-independent molecular detection techniques. In this review, we literaturely summarise the aggravation or improvement of metabolic diseases by role of gut microbiota, probiotics/prebiotic treatment.
authors.affiliation: Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming, Yunnan 650500, China; Medical Faculty, Kunming University of Science and Technology, Kunming, Yunnan 650500, China; Genetics and Pharmacogenomics Laboratory, Kunming University of Science and Technology, Kunming, Yunnan 650500, China. Electronic address: 657151276@qq.com.
authors.forename: Y B
authors.initials: YB
authors.lastname: Kang
authors.affiliation: Medical Faculty, Kunming University of Science and Technology, Kunming, Yunnan 650500, China; Pathogen Biology Laboratory, Kunming University of Science and Technology, Kunming, Yunnan 650500, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Cai
authors.affiliation: Medical Faculty, Kunming University of Science and Technology, Kunming, Yunnan 650500, China; Department of Cardiology, First People's Hospital of Yunnan, Kunming, Yunnan 650500, China.
authors.forename: H
authors.initials: H
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001249:Asthma / Q000276:immunology / Q000382:microbiology*; D000069196:Gastrointestinal Microbiome / Q000276:immunology*; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology / Q000382:microbiology*; D056692:Prebiotics; D019936:Probiotics / Q000627:therapeutic use
chemical_list: D056692:Prebiotics
keywords: Allergy/asthma; Gut microbiota; Inflammation; Probiotics/prebiotic treatment