title: Two new coumarins from the bark of Streblus indicus (Bur.) Corner.
abstract: Two new coumarins 7-O-(6-O-(5-O-3,4,5-tri-methoxycinnamate-β-d-apiofuranosyl-β-d-glucopyranosyl)-6-methoxy coumarin (1) and 7-O-(6-O-(4-(2-hydroxy-1-hydroxymethyl-ethoxy)-3-methoxy-cinnamyl)-β-d-glucopyranosyl)-6-methoxy coumarin (2), along with 10 known metabolites, were isolated from the bark of Streblus indicus, their structures were identified by comparison of experimental and published spectroscopic data. (S)-marmesinin (6) and scoparone (7) exhibited moderate antimicrobial activity in vitro against Staphylococcus aureus strain with the MIC values of 62.5 and 125.0 μg/mL, respectively. Betulinic acid showed inhibitory activity in vitro against MCF-7 cell with IC50value of 9.5 ± 0.1 μM.
authors.affiliation: a State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy , Guangxi Normal University , Guilin , P.R. China.|b Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization , Guangxi Institute of Botany , Guilin , P.R. China.
authors.forename: Ruijie
authors.initials: R
authors.lastname: He
authors.affiliation: a State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy , Guangxi Normal University , Guilin , P.R. China.
authors.forename: Shengping
authors.initials: S
authors.lastname: Deng
authors.affiliation: a State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy , Guangxi Normal University , Guilin , P.R. China.
authors.forename: Hui
authors.initials: H
authors.lastname: Nie
authors.affiliation: c Guangxi Key Laboratory of Tradtional Chinese Medicine Quality Stardands , Guangxi Insitute of Chinese Medicine & Pharmaceutical Science , Nanning , P.R. China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Huang
authors.affiliation: c Guangxi Key Laboratory of Tradtional Chinese Medicine Quality Stardands , Guangxi Insitute of Chinese Medicine & Pharmaceutical Science , Nanning , P.R. China.
authors.forename: Buming
authors.initials: B
authors.lastname: Liu
authors.affiliation: a State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy , Guangxi Normal University , Guilin , P.R. China.
authors.forename: Ruiyun
authors.initials: R
authors.lastname: Yang
authors.affiliation: a State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy , Guangxi Normal University , Guilin , P.R. China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Huang
authors.affiliation: a State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy , Guangxi Normal University , Guilin , P.R. China.
authors.forename: Dexiong
authors.initials: D
authors.lastname: Zhou
authors.affiliation: a State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy , Guangxi Normal University , Guilin , P.R. China.
authors.forename: Huangcan
authors.initials: H
authors.lastname: Chen
authors.affiliation: a State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy , Guangxi Normal University , Guilin , P.R. China.|c Guangxi Key Laboratory of Tradtional Chinese Medicine Quality Stardands , Guangxi Insitute of Chinese Medicine & Pharmaceutical Science , Nanning , P.R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.affiliation: a State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy , Guangxi Normal University , Guilin , P.R. China.
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D045744:Cell Line, Tumor; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005663:Furans / Q000494:pharmacology; D006801:Humans; D029586:Moraceae / Q000737:chemistry*; D024301:Plant Bark / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D003374:Coumarins; D005663:Furans; C495190:marmesinin; C018145:scoparone
keywords: Streblus; Streblus indicus (Bur.) Corner; antimicrobial activity; coumarins; cytotoxicity