title: Chemical Synthesis of Antimicrobial Peptides.
abstract: Solid-phase peptide synthesis (SPPS) is the method of choice for chemical synthesis of peptides. In this nonspecialist review, we describe commonly used resins, linkers, protecting groups, and coupling reagents in 9-fluorenylmethyloxycarbonyl (Fmoc) SPPS. Finally, a detailed protocol for manual Fmoc SPPS is presented.
authors.affiliation: Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen, 2100, Denmark.
authors.forename: Lena
authors.initials: L
authors.lastname: Münzker
authors.affiliation: Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen, 2100, Denmark.
authors.forename: Alberto
authors.initials: A
authors.lastname: Oddo
authors.affiliation: Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen, 2100, Denmark. prh@sund.ku.dk.
authors.forename: Paul R
authors.initials: PR
authors.lastname: Hansen
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D060327:Solid-Phase Synthesis Techniques / Q000295:instrumentation / Q000379:methods
chemical_list: D000596:Amino Acids; D000890:Anti-Infective Agents; D010455:Peptides
keywords: 9-Fluorenylmethyloxycarbonyl (Fmoc) solid-phase peptide synthesis; DIC; Oxyma