title: Incremental Value of 18F-Fluorocholine PET/CT in the Localization of Double Parathyroid Adenomas.
abstract: A 73-year-old man displaying primary hyperparathyroidism with severe hypercalcemia (Ca: 4.1 mmol/l, PTH > 600 pmol/l) was referred for preoperative localization of a parathyroid adenoma. Tc-pertechnetate and Tc-sestaMIBI dual tracer scintigraphy displayed a mild focal uptake in the projection of the right thyroid lobe with negative ultrasonography. F-Fluorocholine PET/CT was quickly performed considering this discrepancy and not only confirmed the scintigraphic findings but also revealed a second contralateral focus of increased uptake, both later confirmed by operative consideration (the two other parathyroid glands are considered normal by the surgeon), pathology, and intraoperative parathyroid hormone assessment.
authors.affiliation: From the *Unité thyroïde, Institut Jean Godinot, Reims; †Service d'endocrinologie, diabétologie, nutrition, ‡Service de chirurgie digestive et endocrinienne, and §Laboratoire d'anatomie et cytologie pathologique, Hôpital Robert Debré, CHU de Reims; ∥Service de médecine nucléaire, Institut Jean Godinot, Reims; ¶Laboratoire de Biophysique, UFR de médecine, Université de Reims Champagne Ardenne; and **CRESTIC EA 3804, Université de Reims Champagne Ardenne.
authors.forename: Paul
authors.initials: P
authors.lastname: Lalire
authors.forename: Sang
authors.initials: S
authors.lastname: Ly
authors.forename: Sophie
authors.initials: S
authors.lastname: Deguelte
authors.forename: Martine
authors.initials: M
authors.lastname: Patey
authors.forename: David
authors.initials: D
authors.lastname: Morland
mesh_terms: D000236:Adenoma / Q000000981:diagnostic imaging*; D000368:Aged; D002794:Choline / Q000031:analogs & derivatives; D006801:Humans; D008297:Male; D010282:Parathyroid Neoplasms / Q000000981:diagnostic imaging*; D000072078:Positron Emission Tomography Computed Tomography; D019275:Radiopharmaceuticals; D013670:Sodium Pertechnetate Tc 99m; D017256:Technetium Tc 99m Sestamibi
chemical_list: D019275:Radiopharmaceuticals; C514960:fluorocholine; D017256:Technetium Tc 99m Sestamibi; D013670:Sodium Pertechnetate Tc 99m; D002794:Choline