title: Survival predictors of Burkitt's lymphoma in children, adults and elderly in the United States during 2000-2013.
abstract: Burkitt's Lymphoma (BL) has three peaks of occurrence, in children, adults and elderly, at 10, 40 and 70 years respectively. To the best of our knowledge, no study has been conducted to assess predictors of survival in the three age groups. We hypothesized that survival predictors may differ by age group. We, therefore, sought to determine survival predictors for BL in these three groups: children (<15 years of age), adults (40-70 years of age) and elderly (>70 years of age). Using the Surveillance, Epidemiology, and End Results (SEER) database covering the years 2000-2013, we identified 797 children, 1,994 adults and 757 elderly patients newly diagnosed with BL. We used adjusted Cox proportional hazards regression models to determine prognostic factors for survival for each age group. Five-year relative survival in BL for children, adults and elderly were 90.4, 47.8 and 28.9%, respectively. Having at least Stage II disease and multiple primaries were associated with higher mortality in the elderly group. In adults, multiple primaries, Stage III or IV disease, African American race and bone marrow primary were associated with increased mortality whereas Stage IV disease and multiple primaries were associated with worse outcome in children. These findings demonstrate commonalities and differences in predictors of survival that may have implications for management of BL patients.
authors.affiliation: Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, FL.
authors.forename: Fahad
authors.initials: F
authors.lastname: Mukhtar
authors.affiliation: Icahn School of Medicine, Mount Sinai School of Medicine, Tisch Cancer Institute, New York, NY.
authors.forename: Paolo
authors.initials: P
authors.lastname: Boffetta
authors.affiliation: Department of Chronic Disease Epidemiology, Yale School of Public Health, Yale University, New Haven, CT.|Yale Cancer Center, New Haven, CT.
authors.forename: Harvey A
authors.initials: HA
authors.lastname: Risch
authors.affiliation: Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33612.
authors.forename: Jong Y
authors.initials: JY
authors.lastname: Park
authors.affiliation: Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, FL.
authors.forename: Omonigho M
authors.initials: OM
authors.lastname: Bubu
authors.affiliation: Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, FL.
authors.forename: Lindsay
authors.initials: L
authors.lastname: Womack
authors.affiliation: Vietnam National Cancer Hospital, Hanoi, Vietnam.|Vietnam National Institute for Cancer Control, Hanoi, Vietnam.
authors.forename: Thuan V
authors.initials: TV
authors.lastname: Tran
authors.affiliation: Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, FL.
authors.forename: Janice C
authors.initials: JC
authors.lastname: Zgibor
authors.affiliation: Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, FL.|Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN.
authors.forename: Hung N
authors.initials: HN
authors.lastname: Luu
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002051:Burkitt Lymphoma / Q000453:epidemiology* / Q000401:mortality*; D002648:Child; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging / Q000379:methods; D011379:Prognosis; D016016:Proportional Hazards Models; D018426:SEER Program; D013997:Time Factors; D016896:Treatment Outcome; D014481:United States
keywords: Burkitt's Lymphoma; SEER; prognosis; survival