title: Comparison of neutrophil functions between two strains of inbred mice.
abstract: In this study, differences between two strains of inbred mice in aspects of neutrophil function, namely Rac1 expression, chemotaxis, nicotinamide adenine dinucleotide phosphate oxidase activity and formation of neutrophil extracellular traps (NETs), were determined. Neutrophils from CBA/CaH mice exhibited weaker Rac1 expression and a slower chemotactic gradient than BALB/c mice. Furthermore, PMA- or fMLP-stimulated neutrophils from CBA/CaH mice generated much less superoxide and NETs than similarly stimulated neutrophils from BALB/c mice. These findings suggest that neutrophils from BALB/c mice are functionally more efficient than those from CBA/CaH mice.
authors.affiliation: Department of Oral Biology.|Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, 56 Lingyuan West Rd, 510055, Guang Zhou.
authors.forename: Xiaohuan
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Affiliated Hospital of Shandong, University of Traditional Chinese Medicine, 16369 Jingshi Road, Jinan, 250101 Shandong Province, China.
authors.forename: Sainan
authors.initials: S
authors.lastname: Zhao
authors.affiliation: Department of Oral Biology.
authors.forename: Luping
authors.initials: L
authors.lastname: Sun
authors.affiliation: Department of Oral Biology.
authors.forename: Wenqing
authors.initials: W
authors.lastname: Li
authors.affiliation: Faculty of Dentistry, University of Toronto, Toronto, ON M5S, Canada.
authors.forename: Michael
authors.initials: M
authors.lastname: Glogauer
authors.affiliation: Department of Oral Biology.|Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, 56 Lingyuan West Rd, 510055, Guang Zhou.
authors.forename: Yan
authors.initials: Y
authors.lastname: Hu
mesh_terms: D000818:Animals; D002633:Chemotaxis; D065206:Extracellular Traps / Q000378:metabolism; D020869:Gene Expression Profiling; D051379:Mice / Q000145:classification* / Q000502:physiology*; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D019255:NADPH Oxidases / Q000032:analysis; D009479:Neuropeptides / Q000096:biosynthesis / Q000235:genetics; D009504:Neutrophils / Q000201:enzymology / Q000276:immunology* / Q000378:metabolism / Q000502:physiology; D013045:Species Specificity; D013481:Superoxides / Q000378:metabolism; D020830:rac1 GTP-Binding Protein / Q000096:biosynthesis / Q000235:genetics
chemical_list: D009479:Neuropeptides; C484602:Rac1 protein, mouse; D013481:Superoxides; D019255:NADPH Oxidases; D020830:rac1 GTP-Binding Protein
keywords: NADPH oxidase; Rac1; chemotaxis; neutrophil; neutrophil extracellular trap