title: Association between low-grade albuminuria and frailty among community-dwelling middle-aged and older people: a cross-sectional analysis from I-Lan Longitudinal Aging Study.
abstract: Frailty is characterized by decreased physiological reserve and increased vulnerability to atherosclerosis and subsequent mortality. Recently, low-grade albuminuria has been proposed as an atherosclerotic risk factor. We aimed to investigate the relationship between low-grade albuminuria and frailty by using cross-sectional data among community-dwelling middle-aged and older people. Totally, 1,441 inhabitants of I-Lan County with normal urinary albumin excretion (urine albumin to urine creatinine ratio [UACR] <30 mg/g) were enrolled (677 men; mean age 63 ± 9 years, range from 50 to 91 years old). Assessment of frailty was based on the 'Fried frailty phenotype' criteria, including weight loss, grip strength, exhaustion, slowness and low physical activity. The study population was stratified into quartiles according to UACR levels. Age, body mass index, hypertension, diabetes, systolic blood pressure, insulin resistance, fasting glucose and high-sensitivity C-reactive protein levels were increased with the increment of UACR (P for trend <0.05). The prevalence of prefrailty/frailty and its components increased across the UACR quartiles. A multivariate stepwise logistic regression analysis revealed that UACR was independently associated with the likelihood of prefrailty/frailty (odds ratio 1.13, 95% CI 1.01-1.27). In conclusion, low-grade albuminuria is associated with the increased prevalence of prefrailty/frailty.
authors.affiliation: Taipei Veterans General Hospital Taoyuan Branch, Taoyuan, Taiwan.|Cardiovascular Research Center, National Yang-Ming University, Taipei, Taiwan.|Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan.
authors.forename: Chun-Chin
authors.initials: CC
authors.lastname: Chang
authors.affiliation: Cardiovascular Research Center, National Yang-Ming University, Taipei, Taiwan.|Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan.|Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.|Division of Cardiology and Cardiovascular Research Center, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan.
authors.forename: Chien-Yi
authors.initials: CY
authors.lastname: Hsu
authors.affiliation: Cardiovascular Research Center, National Yang-Ming University, Taipei, Taiwan.|Division of Cardiology, Department of Medicine; Taipei Veterans General Hospital, Taipei, Taiwan.
authors.forename: Ting-Yung
authors.initials: TY
authors.lastname: Chang
authors.affiliation: Cardiovascular Research Center, National Yang-Ming University, Taipei, Taiwan.|Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan.|Division of Cardiology, Department of Medicine; Taipei Veterans General Hospital, Taipei, Taiwan.
authors.forename: Po-Hsun
authors.initials: PH
authors.lastname: Huang
authors.affiliation: Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei, Taiwan.|Aging and Health Research Center, National Yang-Ming University, Taipei, Taiwan.
authors.forename: Li-Kuo
authors.initials: LK
authors.lastname: Liu
authors.affiliation: Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei, Taiwan.|Aging and Health Research Center, National Yang-Ming University, Taipei, Taiwan.|Institute of Public Health, National Yang-Ming University, Taipei, Taiwan.
authors.forename: Liang-Kung
authors.initials: LK
authors.lastname: Chen
authors.affiliation: Cardiovascular Research Center, National Yang-Ming University, Taipei, Taiwan.|Department of Medical Research; Taipei Veterans General Hospital, Taipei, Taiwan.|Institute of Pharmacology, National Yang-Ming University, Taipei, Taiwan.
authors.forename: Jaw-Wen
authors.initials: JW
authors.lastname: Chen
authors.affiliation: Cardiovascular Research Center, National Yang-Ming University, Taipei, Taiwan.|Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan.|Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.|Department of Medical Research; Taipei Veterans General Hospital, Taipei, Taiwan.
authors.forename: Shing-Jong
authors.initials: SJ
authors.lastname: Lin
mesh_terms: D000368:Aged; D000375:Aging / Q000652:urine*; D000419:Albuminuria / Q000150:complications* / Q000652:urine; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D003404:Creatinine / Q000652:urine; D003430:Cross-Sectional Studies; D005260:Female; D000073496:Frailty / Q000209:etiology* / Q000652:urine; D006801:Humans; D006973:Hypertension / Q000652:urine; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D013624:Taiwan; D016482:Urinalysis / Q000379:methods
chemical_list: D003404:Creatinine