title: The application of lipidomics to biomarker research and pathomechanisms in Alzheimer's disease.
abstract: OBJECTIVE
  Alzheimer's disease is the most common cause of dementia. There are still no disease modifying treatments that can cure or slow disease progression. Recently, Alzheimer's disease researchers have attempted to improve early detection and diagnostic criteria for Alzheimer's disease, with the rationale that treatment of disease, or even prevention, may be more successful during the early preclinical stages of Alzheimer's disease when neurodegenerative damage is not as widespread. As the brain has a high lipid content, lipidomics may offer novel insights into the underlying pathogenesis of Alzheimer's disease. This review reports on recent developments in the relatively unexplored field of lipidomics in Alzheimer's disease, including novel biomarkers and pathomechanisms of Alzheimer's disease.
  
  
  RESULTS
  Numerous biomarker panels involving phospholipids and sphingolipids have been proposed, indicating perturbed lipid metabolism in early stages of Alzheimer's disease. Future strategies targeting these metabolic changes through dietary supplementation could have therapeutic benefits in at-risk individuals.
  
  
  CONCLUSIONS
  Dysregulated lipid metabolism could reflect pathological changes in synaptic function and neuronal membranes, leading to cognitive decline. However, extensive validation in large independent cohorts is required before lipid biomarkers can be used clinically to assess Alzheimer's disease risk and progression.
authors.affiliation: aCentre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine bBioanalytical Mass Spectrometry Facility cSchool of Medical Sciences, Faculty of Medicine, University of New South Wales dNeuropsychiatric Institute, Euroa Centre, Prince of Wales Hospital, Sydney, Australia.
authors.forename: Matthew W
authors.initials: MW
authors.lastname: Wong
authors.forename: Nady
authors.initials: N
authors.lastname: Braidy
authors.forename: Anne
authors.initials: A
authors.lastname: Poljak
authors.forename: Perminder S
authors.initials: PS
authors.lastname: Sachdev
mesh_terms: D000544:Alzheimer Disease / Q000175:diagnosis* / Q000503:physiopathology* / Q000628:therapy; D015415:Biomarkers; D001921:Brain / Q000503:physiopathology; D042241:Early Diagnosis; D006801:Humans; D050356:Lipid Metabolism / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D012106:Research; D013569:Synapses / Q000502:physiology
chemical_list: D015415:Biomarkers