title: [Perampanel in pharmacotherapy of focal epilepsy: the efficacy and tolerability in routine clinical practice].
abstract: OBJECTIVE
  To analyze the efficacy and tolerability of the innovative drug perampanel (PER) as add-on treatment of focal epilepsy in patients older than 12 years.
  
  
  METHODS
  Forty-six patients with focal epilepsy, aged from 12 to 63 years, mean age 31.7 years, were studied.
  
  
  CONCLUSIONS
  A decrease in the frequency of all types of seizures by >50% was noted in 46,5% of patients. Stopping of all types of seizures was found in 25.6% of patients, i.e. in every fourth patient, stopping of secondary-generalized seizures in 39.5%. Adverse effects (AE) were identified in 13 (28.2%) of patients, including aggressiveness - 6 (13.0%); other AE were less frequent (<10%): sleepiness (8.7%), dizziness (4.3%), postural instability (4.3%), irritability (4.3%). PER was withdrawn in 3 (6.5%) patients due to AE. Mean effective dose was 6 mg/day. Quality-of-life improved in the majority of patients (71.7%).
authors.affiliation: Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia.
authors.forename: I A
authors.initials: IA
authors.lastname: Zhidkova
authors.affiliation: Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia.
authors.forename: V A
authors.initials: VA
authors.lastname: Karlov
authors.affiliation: Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia.
authors.forename: P N
authors.initials: PN
authors.lastname: Vlasov
mesh_terms: D000293:Adolescent; D000328:Adult; D000374:Aggression; D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D019955:Conduct Disorder; D004244:Dizziness; D004359:Drug Therapy, Combination; D004828:Epilepsies, Partial / Q000188:drug therapy*; D006801:Humans; D008875:Middle Aged; D009570:Nitriles; D011728:Pyridones / Q000009:adverse effects / Q000627:therapeutic use*; D012640:Seizures; D016896:Treatment Outcome; D014717:Vertigo; D055815:Young Adult
chemical_list: D000927:Anticonvulsants; D009570:Nitriles; D011728:Pyridones; C551441:perampanel