title: Activity of the aqueous extract of Schinus terebinthifolius Raddi on strains of the Candida genus.
abstract: ObjectivesTo evaluate the antifungal susceptibility profile of the aqueous extract of the bark ofSchinus terebinthifoliusRaddi against the strains of the genusCandida.MethodsBy using the disk diffusion method, 50 samples of the genusCandida(Candida albicans;Candida krusei;Candida glabrata; andCandida tropicalis), isolated from patients receiving treatment at Hospital Santa Casa de Misericórdia de São Paulo, and 1 American Type Culture Collection (ATCC) sample of each species were tested against: the isolated aqueous extract of the bark ofSchinus terebinthifoliusRaddi, isolated nystatin, and the association of nystatin and the aqueous extract ofSchinus terebinthifoliusRaddi.ResultsThere were no significant differences regarding the different strains ofCandidatested. In the presence of the aqueous extract ofSchinus terebinthifoliusRaddi, no inhibition halo was visible. Isolated nystatin formed an inhibition halo measuring respectively 18.50 mm and 19.50 mm for theCandida albicansspecies and the others referred to as non-Candida albicans(Candida krusei;Candida glabrata; andCandida tropicalis). The association of nystatin and the aqueous extract ofSchinus terebinthifoliusRaddi resulted in inhibition halos measuring 14.25 mm and 16.50 mm respectively. The comparisons of these results are statistically significant (p< 0,001).ConclusionThe aqueous extract ofSchinus terebinthifoliusRaddi showed no antifungal activity in vitro against the strains tested, whereas the association of nystatin and the aqueous extract ofSchinus terebinthifoliusRaddi caused a decrease in the inhibition halo when compared with isolated nystatin.
authors.affiliation: Santa Casa de Sao Paulo School of Medical Sciences, São Paulo, SP, Brazil.
authors.forename: Kátia Andrea de Menezes
authors.initials: KA
authors.lastname: Torres
authors.affiliation: Department of Gynecology and Obstetrics, School of Medical Sciences, Santa Casa de São Paulo, São Paulo, SP, Brazil.
authors.forename: Sônia Maria Rolim Rosa
authors.initials: SM
authors.lastname: Lima
authors.affiliation: School of Medical Sciences, Department of Pathological Sciences, Santa Casa de São Paulo, São Paulo, Brazil.
authors.forename: Suely Mitoi Ykko
authors.initials: SM
authors.lastname: Ueda
mesh_terms: D027926:Anacardiaceae / Q000737:chemistry*; D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects*; D006801:Humans; D009761:Nystatin / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D010936:Plant Extracts; D009761:Nystatin