title: Matrine derivative YF-18 inhibits lung cancer cell proliferation and migration through down-regulating Skp2.
abstract: Lung cancer is the leading cause of cancer related death which needs novel drugs to improve patient outcomes. In this study, we examined the ability of YF-18, a novel matrine derivative to inhibit the growth and migration of lung cancer cells. By cell cycle analysis, wound healing and transwell assays, we found that YF-18 induced G2/M cell cycle arrest and inhibited migration of lung cancer cells in a dose-dependent manner. Further results indicated that YF-18 inhibited cell proliferation and migration through down-regulating Skp2 and up-regulating its substrates, p27 and E-cadherin. Moreover, YF-18 inhibited A549-luciferase cell xenograft tumor growth in a dose-dependent manner. The findings indicate that YF-18 bears therapeutic potentials for lung cancer.
authors.affiliation: School of Chemistry and Chemical Engineering, Guangxi University, Nanning, Guangxi, PR China.
authors.forename: Lichuan
authors.initials: L
authors.lastname: Wu
authors.affiliation: State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, PR China.
authors.forename: Guizhen
authors.initials: G
authors.lastname: Wang
authors.affiliation: Guangxi Scientific Research Center of Traditional Chinese Medicine, Guangxi University of Chinese Medicine, Nanning, Guangxi, PR China.
authors.forename: Jinrui
authors.initials: J
authors.lastname: Wei
authors.affiliation: Affiliated Tumour Hospital of Guangxi Medical University, Nanning, Guangxi, PR China.
authors.forename: Na
authors.initials: N
authors.lastname: Huang
authors.affiliation: School of Chemistry and Chemical Engineering, Guangxi University, Nanning, Guangxi, PR China.
authors.forename: Sen
authors.initials: S
authors.lastname: Zhang
authors.affiliation: School of Chemistry and Chemical Engineering, Guangxi University, Nanning, Guangxi, PR China.
authors.forename: Fangfang
authors.initials: F
authors.lastname: Yang
authors.affiliation: Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, PR China.
authors.forename: Ming
authors.initials: M
authors.lastname: Li
authors.affiliation: State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, PR China.
authors.forename: Guangbiao
authors.initials: G
authors.lastname: Zhou
authors.affiliation: School of Chemistry and Chemical Engineering, Guangxi University, Nanning, Guangxi, PR China.
authors.forename: Lisheng
authors.initials: L
authors.lastname: Wang
mesh_terms: D000072283:A549 Cells; D000470:Alkaloids / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D004195:Disease Models, Animal; D015536:Down-Regulation; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D011807:Quinolizines / Q000737:chemistry / Q000494:pharmacology*; D011897:Random Allocation; D044786:S-Phase Kinase-Associated Proteins / Q000378:metabolism*; D000093842:Matrines
chemical_list: D000470:Alkaloids; D011807:Quinolizines; D044786:S-Phase Kinase-Associated Proteins; D000093842:Matrines
keywords: Skp2; lung cancer; matrine derivative; migration; proliferation