title: Beating the Clock in T-cell Acute Lymphoblastic Leukemia.
abstract: CDK4/6 inhibition was synergistic with dexamethasone and everolimus but antagonistic with conventional chemotherapy in T-cell acute lymphoblastic leukemia (T-ALL) preclinical models. Cyclin-dependent kinase inhibition in combination with glucocorticoids and mTOR inhibition offers a unique therapeutic opportunity in T-ALL.Clin Cancer Res; 23(4); 873-5. ©2016 AACRSee related article by Pikman et al., p. 1012.
authors.affiliation: Department of Pediatrics, Perlmutter Cancer Center, NYU Langone Medical Center, New York, New York. william.carroll@nyumc.org.
authors.forename: William L
authors.initials: WL
authors.lastname: Carroll
authors.affiliation: Department of Pathology, Perlmutter Cancer Center, NYU Langone Medical Center, New York, New York.
authors.forename: Iannis
authors.initials: I
authors.lastname: Aifantis
authors.affiliation: Department of Pediatrics, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Raetz
mesh_terms: D045744:Cell Line, Tumor; D051358:Cyclin-Dependent Kinase 4 / Q000037:antagonists & inhibitors / Q000235:genetics; D003907:Dexamethasone / Q000627:therapeutic use; D019008:Drug Resistance, Neoplasm / Q000187:drug effects*; D004357:Drug Synergism; D000068338:Everolimus / Q000627:therapeutic use; D006801:Humans; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases / Q000037:antagonists & inhibitors / Q000235:genetics
chemical_list: D047428:Protein Kinase Inhibitors; D003907:Dexamethasone; D000068338:Everolimus; C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases; C495900:CDK4 protein, human; D051358:Cyclin-Dependent Kinase 4