title: Detailed Measurement of Wall Strain with 3D Speckle Tracking in the Aortic Root: A Case of Bionic Support for Clinical Decision Making.
abstract: Three-dimensional (3D) wall motion tracking (WMT) based on ultrasound imaging enables estimation of aortic wall motion and deformation. It provides insights into changes in vascular compliance and vessel wall properties essential for understanding the pathogenesis and progression of aortic diseases. In this report, we employed the novel 3D WMT analysis on the ascending aorta aneurysm (AA) to estimate local aortic wall motion and strain in case of a patient scheduled for replacement of the aortic root. Although progression of the diameter indicates surgical therapy, at present we addressed the question for optimal surgical time point. According to the data, AA in our case has enlarged diameter and subsequent reduced circumferential wall strain, but area tracking data reveals almost normal elastic properties. Virtual remodeling of the aortic root opens a play list for different loading conditions to determine optimal surgical intervention in time.
authors.affiliation: Department of Heart Surgery, Philipps University, Marburg, Germany; Biochemical Pharmacological Center, Cardiovascular Res Lab, Philipps University, Marburg, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Vogt
authors.affiliation: Department of Cardiology, Universitätsklinikum Marburg und Gießen GmbH, Marburg, Germany.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Karatolios
authors.affiliation: Institute for Cell Biology and Neuroscience, Goethe University, Frankfurt (Main), Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Wittek
authors.affiliation: Institute for Cell Biology and Neuroscience, Goethe University, Frankfurt (Main), Germany.
authors.forename: Christopher
authors.initials: C
authors.lastname: Blasé
authors.affiliation: Institute for Pathology, Philipps University, Marburg, Germany.
authors.forename: Anette
authors.initials: A
authors.lastname: Ramaswamy
authors.affiliation: Department of Heart Surgery, Universitätsklinikum Marburg und Gießen GmbH, Marburg, Germany.
authors.forename: Nikolas
authors.initials: N
authors.lastname: Mirow
authors.affiliation: Department of Heart Surgery, Universitätsklinikum Marburg und Gießen GmbH, Marburg, Germany.
authors.forename: Rainer
authors.initials: R
authors.lastname: Moosdorf
keywords: aneurysm; aortic disease; biomechanics; echocardiography