title: Treatment of Pseudomonas Keratitis by Continuous Infusion of Topical Antibiotics With the Morgan Lens.
abstract: OBJECTIVE
  Despite following standard treatment, Pseudomonas keratitis can continue to progress and result in loss of vision or of the eye. Our cases demonstrate that the Morgan Lens can be an effective topical antibiotic delivery vehicle in advanced keratitis.
  
  
  METHODS
  Two patients (3 eyes) with Pseudomonas keratitis were included in this report after failing to respond to intense inpatient topical treatment. Because loss of the eyes was imminent, the Morgan Lenses were used for continuous lavage with ceftazidime (50 mg/mL), in conjunction with other conventional treatment.
  
  
  RESULTS
  Three days after lavage, corneal cultures became negative in all eyes. Infusion was continued for at least a week to ensure sterilization of the infection before switching to standard topical therapy. The infection in both cases was promptly eradicated and the eyes were rescued.
  
  
  CONCLUSIONS
  The Morgan Lens can be a viable alternative in treating severe and aggressive infectious keratitis or sclerokeratitis. Application of the Morgan Lens is noninvasive and requires minimal training. Intravenous tubing connectors allow for easy swapping between medications, simultaneous administration of multiple medications, and titration of dosing. Additionally, it is cost-effective as the low demand for nursing care essentially eliminates the need for intensive care unit admission.
authors.affiliation: *NeuVision Medical Institute, Tucson, AZ; †Department of Ophthalmology and Visual Science, College of Medicine, University of Arizona, Tucson, AZ; ‡Updegraff Laser Vision, St Petersburg, FL; and §Department of Ophthalmology, Baylor College of Medicine, Houston, TX.
authors.forename: Mingwu
authors.initials: M
authors.lastname: Wang
authors.forename: Whitney A
authors.initials: WA
authors.lastname: Smith
authors.forename: Joshua K
authors.initials: JK
authors.lastname: Duncan
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Miller
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002442:Ceftazidime / Q000008:administration & dosage*; D002648:Child; D003261:Contact Lenses; D016503:Drug Delivery Systems / Q000295:instrumentation*; D015818:Eye Infections, Bacterial / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007223:Infant; D007634:Keratitis / Q000188:drug therapy*; D011552:Pseudomonas Infections / Q000188:drug therapy*; D011550:Pseudomonas aeruginosa; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D002442:Ceftazidime