title: Beta-2-glycoprotein-1 and alpha-1-antitrypsin as urinary markers of renal cancer in von Hippel-Lindau patients.
abstract: BACKGROUND
  Von Hippel-Lindau disease (VHLD) is a rare inherited neoplastic syndrome. Among all the VHLD-associated tumors, clear cell renal cell carcinoma (ccRCC) is the major cause of death.
  
  
  OBJECTIVE
  The aim of this paper is the discovery of new non-invasive biomarker for the monitoring of VHLD patients.
  
  
  METHODS
  We compared the urinary proteome of VHLD patients, ccRCC patients and healthy volunteers.
  
  
  RESULTS
  Among all differentially expressed proteins, alpha-1-antitrypsin (A1AT) and APOH (beta-2-glycoprotein-1) are strongly over-abundant only in the urine of VHLD patients with a history of ccRCC.
  
  
  CONCLUSIONS
  A1AT and APOH could be promising non-invasive biomarkers.
authors.affiliation: a Department of Molecular Biotechnology and Health Sciences , Molecular Biotechnology Center, University of Turin Medical School , Turin , Italy.|b Center for Experimental Research and Medical Studies (CeRMS), Città della Salute e della Scienza , Ospedale San Giovanni Battista , Turin , Italy.
authors.forename: Giorgia
authors.initials: G
authors.lastname: Mandili
authors.affiliation: c Department of Oncology , University of Turin Medical School , Turin , Italy.
authors.forename: Agata
authors.initials: A
authors.lastname: Notarpietro
authors.affiliation: d Department of Surgical Sciences , University of Turin Medical School , Turin , Italy.
authors.forename: Amina
authors.initials: A
authors.lastname: Khadjavi
authors.affiliation: e Department of Urology , Azienda Ospedaliera Città della Salute e Della Scienza di Torino - Molinette , Turin , Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Allasia
authors.affiliation: e Department of Urology , Azienda Ospedaliera Città della Salute e Della Scienza di Torino - Molinette , Turin , Italy.
authors.forename: Antonino
authors.initials: A
authors.lastname: Battaglia
authors.affiliation: f Department of Endocrinology, Diabetology and Metabolism , Azienda Ospedaliera Città della Salute e Della Scienza di Torino - Molinette , Turin , Italy.
authors.forename: Barbara
authors.initials: B
authors.lastname: Lucatello
authors.affiliation: e Department of Urology , Azienda Ospedaliera Città della Salute e Della Scienza di Torino - Molinette , Turin , Italy.
authors.forename: Bruno
authors.initials: B
authors.lastname: Frea
authors.affiliation: c Department of Oncology , University of Turin Medical School , Turin , Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Turrini
authors.affiliation: a Department of Molecular Biotechnology and Health Sciences , Molecular Biotechnology Center, University of Turin Medical School , Turin , Italy.|b Center for Experimental Research and Medical Studies (CeRMS), Città della Salute e della Scienza , Ospedale San Giovanni Battista , Turin , Italy.|g Immunogenetics and Transplantation Biology Unit, Azienda Ospedaliera Città della Salute e della Scienza , Ospedale San Giovanni Battista , Turin , Italy.
authors.forename: Francesco
authors.identifier: http://orcid.org/0000-0002-6259-5666
authors.initials: F
authors.lastname: Novelli
authors.affiliation: c Department of Oncology , University of Turin Medical School , Turin , Italy.
authors.forename: Giuliana
authors.initials: G
authors.lastname: Giribaldi
authors.affiliation: e Department of Urology , Azienda Ospedaliera Città della Salute e Della Scienza di Torino - Molinette , Turin , Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Destefanis
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000652:urine*; D015153:Blotting, Western; D002292:Carcinoma, Renal Cell / Q000150:complications / Q000175:diagnosis / Q000652:urine*; D015180:Electrophoresis, Gel, Two-Dimensional; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000150:complications / Q000652:urine*; D008297:Male; D008875:Middle Aged; D020543:Proteome / Q000032:analysis; D000515:alpha 1-Antitrypsin / Q000652:urine*; D053482:beta 2-Glycoprotein I / Q000652:urine*; D006623:von Hippel-Lindau Disease / Q000150:complications / Q000652:urine*
chemical_list: D014408:Biomarkers, Tumor; D020543:Proteome; D000515:alpha 1-Antitrypsin; D053482:beta 2-Glycoprotein I
keywords: Von Hippel–Lindau disease; beta-2-glycoprotein-1 and alpha-1-antitrypsin; proteomics; renal cancer; urine