title: Potential Mechanisms Underlying the Therapeutic Effects of Electroconvulsive Therapy.
abstract: In spite of the extensive application of electroconvulsive therapy (ECT), how it works remains unclear. So far, researchers have made great efforts in figuring out the mechanisms underlying the effect of ECT treatment via determining the levels of neurotransmitters and cytokines and using genetic and epigenetic tools, as well as structural and functional neuroimaging. To help address this question and provide implications for future research, relevant clinical trials and animal experiments are reviewed.
authors.affiliation: Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, Shanghai, 200030, China.
authors.forename: Jiangling
authors.initials: J
authors.lastname: Jiang
authors.affiliation: Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, Shanghai, 200030, China.|Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, 200030, China.|Brain Science and Technology Research Center, Shanghai Jiao Tong University, Shanghai, 200030, China.
authors.forename: Jijun
authors.initials: J
authors.lastname: Wang
authors.affiliation: Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, Shanghai, 200030, China. chunbo_li@163.com.|Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, 200030, China. chunbo_li@163.com.|Brain Science and Technology Research Center, Shanghai Jiao Tong University, Shanghai, 200030, China. chunbo_li@163.com.
authors.forename: Chunbo
authors.initials: C
authors.lastname: Li
mesh_terms: D000818:Animals; D002560:Cerebrovascular Circulation / Q000502:physiology*; D016207:Cytokines / Q000378:metabolism*; D004565:Electroconvulsive Therapy; D006801:Humans; D001523:Mental Disorders / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D009414:Nerve Growth Factors / Q000378:metabolism*; D009473:Neuronal Plasticity / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000378:metabolism*
chemical_list: D016207:Cytokines; D009414:Nerve Growth Factors; D018377:Neurotransmitter Agents
keywords: Electroconvulsive therapy; Epigenetics; Inflammatory factors; Neuroimaging; Neurotransmitters; Neurotrophins