title: Thromboelastogram as a Tool to Predict Hypercoagulability in Children With Cystic Fibrosis.
abstract: Increased thrombophilic tendency in patients with cystic fibrosis (CF) has recently been reported. The determinants of thrombosis in children with CF remain largely unknown. Our aim in this study was to evaluate the thromboelastography (TEG) profile of children with CF through ROTEM (whole blood rotation thromboelastometry). Nineteen patients with CF and 20 controls were included in the study. Whole blood count, prothrombin time, activated prothrombin time, fibrinogen, d-dimer levels, and ROTEM assays (INTEM, EXTEM) were performed. Clotting time, clot formation time (CFT), and maximum clot firmness (MCF) were determined by INTEM and EXTEM analysis. In INTEM assay, MCF ( P = .001) value was significantly increased and CFT ( P = .031) value was decreased in patients with CF compared with those of the control group. In the EXTEM assay, there was a similar significant increase in MCF ( P = .023) value in patients with CF compared with that of the control group. There was a significant positive correlation between fibrinogen levels and MCF in EXTEM ( r = .72) and INTEM ( r = .76) assays, whereas there was a negative correlation with CFT in EXTEM ( r = -.61) and INTEM ( r = -.67). The results of our study indicated that TEG profiles in patients with CF were more hypercoagulable compared with those of the control group.
authors.affiliation: 1 Department of Pediatric Allergy and Immunology, Faculty of Medicine, Osmangazi University, Eskisehir, Turkey.
authors.forename: Hülya
authors.initials: H
authors.lastname: Anıl
authors.affiliation: 2 Department of Pediatric Nutrition and Metabolism, Faculty of Medicine, Osmangazi University, Eskisehir, Turkey.
authors.forename: Gonca
authors.initials: G
authors.lastname: Kılıç Yıldırım
authors.affiliation: 1 Department of Pediatric Allergy and Immunology, Faculty of Medicine, Osmangazi University, Eskisehir, Turkey.
authors.forename: Koray
authors.initials: K
authors.lastname: Harmancı
authors.affiliation: 3 Department of Pediatric Hematology and Oncology, Faculty of Medicine, Osmangazi University, Eskisehir, Turkey.
authors.forename: Ayşe
authors.initials: A
authors.lastname: Bozkurt Turhan
authors.affiliation: 4 Department of Hematology, Faculty of Medicine, Osmangazi University, Eskisehir, Turkey.
authors.forename: Olga Meltem
authors.initials: OM
authors.lastname: Akay
authors.affiliation: 3 Department of Pediatric Hematology and Oncology, Faculty of Medicine, Osmangazi University, Eskisehir, Turkey.
authors.forename: Özcan
authors.initials: Ö
authors.lastname: Bör
authors.affiliation: 2 Department of Pediatric Nutrition and Metabolism, Faculty of Medicine, Osmangazi University, Eskisehir, Turkey.
authors.forename: Sultan
authors.initials: S
authors.lastname: Aydoğdu
authors.affiliation: 1 Department of Pediatric Allergy and Immunology, Faculty of Medicine, Osmangazi University, Eskisehir, Turkey.
authors.forename: Abdulkadır
authors.initials: A
authors.lastname: Kocak
mesh_terms: D000293:Adolescent; D001780:Blood Coagulation Tests; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000097:blood*; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D008297:Male; D013916:Thrombelastography / Q000379:methods*; D019851:Thrombophilia / Q000175:diagnosis*
chemical_list: D005340:Fibrinogen
keywords: cystic fibrosis; hypercoagulability; thromboelastogram