title: Sensorimotor gating in healthy adults tested over a 15 year period.
abstract: Prepulse inhibition (PPI) of startle, an operational measure of sensorimotor gating, is used to study normal and pathological brain function. From 2001 to 2016, we screened healthy subjects (HS) to establish their suitability for tests of drug effects on PPI. Because of the size and systematic characterization of this sample across variables of relevance to PPI, we now report these screening results.
  
  
  
  Acoustic startle and PPI were assessed in HS to identify those eligible for studies of drug effects on PPI from 2001 to 2016, yielding 457 "eligible" subjects.
  
  
  
  Data confirmed the consistency of PPI across this 15-year period, and supported the role of several variables previously reported to moderate either startle or PPI.
  
  
  
  Startle and PPI are robust physiological measures that are predictably moderated by specific physiological variables in healthy adults. As such, these measures serve as robust markers of neurobiological processes in healthy and patient populations.
authors.affiliation: Department of Psychiatry, University of California San Diego (UCSD) School of Medicine, 9500 Gilman Dr., La Jolla, CA, 92093-080, United States. Electronic address: nswerdlow@ucsd.edu.
authors.forename: Neal R
authors.initials: NR
authors.lastname: Swerdlow
authors.affiliation: Department of Psychiatry, University of California San Diego (UCSD) School of Medicine, 9500 Gilman Dr., La Jolla, CA, 92093-080, United States.
authors.forename: Savita G
authors.initials: SG
authors.lastname: Bhakta
authors.affiliation: Department of Psychiatry, University of California San Diego (UCSD) School of Medicine, 9500 Gilman Dr., La Jolla, CA, 92093-080, United States.
authors.forename: Brinda K
authors.initials: BK
authors.lastname: Rana
authors.affiliation: Department of Psychiatry, University of California San Diego (UCSD) School of Medicine, 9500 Gilman Dr., La Jolla, CA, 92093-080, United States.
authors.forename: Justin
authors.initials: J
authors.lastname: Kei
authors.affiliation: Department of Psychiatry, University of California San Diego (UCSD) School of Medicine, 9500 Gilman Dr., La Jolla, CA, 92093-080, United States.
authors.forename: Hsun-Hua
authors.initials: HH
authors.lastname: Chou
authors.affiliation: Department of Psychiatry, University of California San Diego (UCSD) School of Medicine, 9500 Gilman Dr., La Jolla, CA, 92093-080, United States.
authors.forename: Jo A
authors.initials: JA
authors.lastname: Talledo
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D065808:Prepulse Inhibition / Q000502:physiology*; D013216:Reflex, Startle / Q000502:physiology*; D055815:Young Adult
keywords: Catechol-O-methyl transferase; Prepulse inhibition; Sensorimotor gating; Startle