title: Patch Test Series for Allergic Perineal Dermatitis in the Diapered Infant.
abstract: BACKGROUND
  Allergic perineal dermatitis (PD) due to diaper wipes, topical medicaments, or diapers has been reported. Although patch testing is the criterion standard for detection of allergic contact dermatitis in children, this is limited by body surface area, decreased tolerance of the patch testing procedure, and increased false-positive rates due to irritant reactions. Therefore, a targeted patch testing series is necessary to better screen diapered infants for possible allergic PD.
  
  
  OBJECTIVE
  We propose 2 patch test series (PD series 1 and 2) to screen infants with possible allergic PD.
  
  
  METHODS
  Allergens are chosen using existing sensitization data of common allergens in children, published case reports, and the collective experience of American Contact Dermatitis Society members through an electronic survey.
  
  
  RESULTS
  PD series 1 includes 23 potential allergens found in wet wipes and topical diaper preparations. PD series 2 contains 10 potential allergens most commonly found in diapers.
  
  
  CONCLUSIONS
  We believe that these judiciously chosen patch test series will increase the yield of detecting the causes of allergic PD while not exposing children to an unnecessarily large screening patch test panel.
authors.affiliation: From the *Section of Pediatric Dermatology, Children's Hospital of Philadelphia, PA; and †Department of Dermatology, University of Pennsylvania, Philadelphia.
authors.forename: JiaDe
authors.initials: J
authors.lastname: Yu
authors.forename: James
authors.initials: J
authors.lastname: Treat
authors.forename: Bruce
authors.initials: B
authors.lastname: Brod
mesh_terms: D000485:Allergens / Q000008:administration & dosage / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis / Q000209:etiology*; D041381:Diapers, Infant / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009824:Ointments / Q000009:adverse effects; D010328:Patch Tests / Q000592:standards*; D018570:Risk Assessment
chemical_list: D000485:Allergens; D009824:Ointments