title: Facile Synthesis for Benzo-1,4-Oxazepine Derivatives by Tandem Transformation of C-N Coupling/C-H Carbonylation.
abstract: A tandem transformation of C-N coupling/C-H carbonylation has been developed for the synthesis of benzo-1,4-oxazepine pharmaceutically derivatives. Notably, this reaction was accomplished by various phenylamine with ally halides under carbon dioxide atmosphere employing 2-(2-dimethylamino-vinyl)-1H-inden-1-olcatalyzed. Furthermore, under the optimized conditions, various benzo-1,4-oxazepine derivatives were obtained in good yields. Finally, a plausible CuI/CuIIImechanism of C-N coupling/C-H carbonylation transformation was proposed.
authors.affiliation: Department of Biology and Environment, Zhejiang A&F University, Shaoxing 311800, Zhejiang, China. 18267573167m@sina.cn.
authors.forename: Xiaojia
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of Biology and Environment, Zhejiang A&F University, Shaoxing 311800, Zhejiang, China. a63214955@sohu.com.
authors.forename: Jiong
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Biology and Environment, Zhejiang A&F University, Shaoxing 311800, Zhejiang, China. 13282210629@163.com.
authors.forename: Zeqin
authors.initials: Z
authors.lastname: Zheng
authors.affiliation: Department of Biology and Environment, Zhejiang A&F University, Shaoxing 311800, Zhejiang, China. 20140041@zafu.edu.cn.
authors.forename: Runsheng
authors.initials: R
authors.lastname: Xu
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry; D002245:Carbon Dioxide / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006219:Halogens / Q000737:chemistry; D015394:Molecular Structure; D010077:Oxazepines / Q000138:chemical synthesis*
chemical_list: D000814:Aniline Compounds; D006219:Halogens; D010077:Oxazepines; D002245:Carbon Dioxide; D003300:Copper
keywords: C-H carbonylation; C-N coupling; benzo-1,4-oxazepine; copper catalyst; tandem transformation