title: Conifer Green Needle Complex in Patients with Precancerous Gastric Lesions: An Observational Pilot Study.
abstract: Objectives.Helicobacter pyloriinfection is common and can lead to precancerous gastric lesions. Standard antibiotic therapy has a failure rate of more than 25% from antibiotic resistance. The primary aim of this observational pilot study was to test the feasibility of a large-scale clinical trial of Conifer Green Needle Complex (CGNC) to treat precancerous gastric lesions. Secondary aims were to investigateH. pyloriinfection, stomach function, and histopathology of the gastric mucosa.Methods. A tablet form of CGNC (extracted fromPinus sylvestrisandPicea abies(L) Karst) was prescribed to 26 patients with precancerous gastric lesions (two tablets, 100 mg CGNC/tablet, three times per day for six months). Another 24 patients received no treatment.Results.Compared with control patients, CGNC-treated patients showed total or partial regression (using the quantitative Rome III diagnostic criteria) of dyspeptic symptoms (92.3%,p< 0.0001), eradication ofH. pyloriinfection (57.1%,p< 0.03), a reduction in endoscopic signs of gastritis (92.3%,p< 0.001), an increase of pepsinogen-pepsin in the gastric juice (57.7%,p< 0.05), and total regression or reduction in the degree of intestinal metaplasia (46.2%,p< 0.05) and lymphoplasmacytic infiltration (53.8%,p< 0.05).Conclusions.This study justifies a randomised-controlled trial with CGNC in patients with atrophic gastritis.
authors.affiliation: Laboratory of Cancer Chemoprevention and Oncopharmacology, N. N. Petrov Research Institute of Oncology, Ministry of Healthcare and Social Development, Saint Petersburg, Russia.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Bespalov
authors.affiliation: Department of Endoscopy, N. N. Petrov Research Institute of Oncology, Ministry of Healthcare and Social Development, Saint Petersburg, Russia.
authors.forename: Alexander
authors.initials: A
authors.lastname: Sherbakov
authors.affiliation: Laboratory of Pathological Morphology, N. N. Petrov Research Institute of Oncology, Ministry of Healthcare and Social Development, Saint Petersburg, Russia.
authors.forename: Viktor
authors.initials: V
authors.lastname: Novik
authors.affiliation: Laboratory of Biochemistry, N. N. Petrov Research Institute of Oncology, Ministry of Healthcare and Social Development, Saint Petersburg, Russia.
authors.forename: Valentin
authors.initials: V
authors.lastname: Kalinovsky
authors.affiliation: Solagran Limited, Biotechnology Company, 98-106 Moray St., South Melbourne, VIC 3205, Australia.
authors.forename: Kamran
authors.initials: K
authors.lastname: Shamsi
authors.affiliation: Solagran Limited, Biotechnology Company, 98-106 Moray St., South Melbourne, VIC 3205, Australia; Saint Petersburg State Forest Technical Academy, Saint Petersburg, Russia.
authors.forename: Vagif
authors.identifier: 0000-0002-5612-0402
authors.initials: V
authors.lastname: Soultanov