title: Relationship between Tissue Distributions of Modified Wuzi Yanzong Prescription () in Rats and Meridian Tropism Theory.
abstract: OBJECTIVE
  To investigate the relationship between tissue distributions of modified Wuzi Yanzong prescription (, MWP) in rats and meridian tropism theory.
  
  
  METHODS
  A high-performance liquid chromatography with Fourier transform-mass spectrometry (HPLC-FT) method was used to identify the metabolites of MWP in different tissues of rats after continued oral administration of MWP for 7 days. The relationship between MWP and meridian tropism theory was studied according to the tissue distributions of the metabolites of MWP in rats and the relevant literature.
  
  
  RESULTS
  Nineteen metabolites, mainly flavanoid compounds, were detected in the different rat tissues and classified to each herb in MWP. Further, it was able to establish that the tissue distributions of the metabolites of MWP were consistent with the descriptions of meridian tropism of MWP available in literature, this result might be useful in clarifying the mechanism of MWP on meridian tropism. In the long run, these data might provide scientific evidence of the meridian tropism theory to further promote the reasonable, effective utilization, and modernization of Chinese medicine.
  
  
  CONCLUSIONS
  The tissue distributions of MWP in vivo were consistent with the descriptions of meridian tropism of MWP.
authors.affiliation: Integrated Laboratory of Traditional Chinese Medicine and Western Medicine, Peking University First Hospital, Beijing, 100034, China.
authors.forename: Lin-Lin
authors.initials: LL
authors.lastname: Wang
authors.affiliation: Integrated Laboratory of Traditional Chinese Medicine and Western Medicine, Peking University First Hospital, Beijing, 100034, China.
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: Li
authors.affiliation: Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
authors.forename: Cai-Sheng
authors.initials: CS
authors.lastname: Wu
authors.affiliation: Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
authors.forename: Jin-Lan
authors.initials: JL
authors.lastname: Zhang
authors.affiliation: Integrated Laboratory of Traditional Chinese Medicine and Western Medicine, Peking University First Hospital, Beijing, 100034, China.
authors.forename: Yi-Xiang
authors.initials: YX
authors.lastname: Song
authors.affiliation: Integrated Laboratory of Traditional Chinese Medicine and Western Medicine, Peking University First Hospital, Beijing, 100034, China.
authors.forename: Fang-Jiao
authors.initials: FJ
authors.lastname: Song
authors.affiliation: Integrated Laboratory of Traditional Chinese Medicine and Western Medicine, Peking University First Hospital, Beijing, 100034, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Fu
authors.affiliation: Integrated Laboratory of Traditional Chinese Medicine and Western Medicine, Peking University First Hospital, Beijing, 100034, China.
authors.forename: Geng-Xin
authors.initials: GX
authors.lastname: Liu
authors.affiliation: Integrated Laboratory of Traditional Chinese Medicine and Western Medicine, Peking University First Hospital, Beijing, 100034, China. wangxuemeibjmu@163.com.
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Wang
mesh_terms: D000818:Animals; D011307:Drug Prescriptions; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D016740:Meridians; D055442:Metabolome; D008954:Models, Biological; D017208:Rats, Wistar; D014018:Tissue Distribution / Q000187:drug effects
chemical_list: D004365:Drugs, Chinese Herbal; C528421:wuzi yanzong
keywords: Chinese medicine; Fourier transform mass spectrometry; high-performance liquid chromatography; meridian tropism; modified Wuzi Yanzong Prescription; tissue distributions