title: Does theMTHFRA1298C Polymorphism Modulate the Cardiorespiratory Response to Training?
abstract: The 5,10-methylenetetrahydrofolate reductase gene (MTHFR) A1298C polymorphic variant is a candidate to explain the individual differences in trainability and response to exercise training. Therefore, the aim of the study was to verify whether the A1298C polymorphism influenced the aerobic and anaerobic performance as well as body and mass composition in young Polish women following low-high impact aerobic exercise training. Two hundred and one women aged 21 ± 1 years (range 19-24) were included in the study. All of them completed a 12-week exercise training program and were measured for selected somatic features, aerobic capacity and cardiorespiratory fitness indices as well as peak anaerobic power and anaerobic capacity, before and after the intervention. A mixed 2 x 2 ANOVA for 20 dependent variables grouped in three categories was conducted. No significant interaction of the genotype with training for body mass and body composition variables was observed. Although, there were three significant genotype x training interactions for maximal oxygen uptake variables, regardless of body mass i.e.: for VO2max (p < 0.05), HRmax (p < 0.0001) and HRAT/HRmax (p < 0.0001). Significantly greater improvement in VO2max was gained by the CC+AC group compared to the AA genotype group. The present results support the hypothesis that individual differences in trainability are at least in part determined by the genetic component and MTHFR A1298C seems to be one of the many polymorphisms involved.
authors.affiliation: University of Szczecin, Faculty of Physical Education and Health Promotion, Szczecin, Poland.
authors.forename: Paweł
authors.initials: P
authors.lastname: Cięszczyk
authors.affiliation: Gdansk University of Physical Education and Sport, Faculty of Tourism and Recreation, Gdansk, Poland.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Zarębska
authors.affiliation: Gdansk University of Physical Education and Sport, Faculty of Tourism and Recreation, Gdansk, Poland.
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Jastrzębski
authors.affiliation: Gdansk University of Physical Education and Sport, Faculty of Tourism and Recreation, Gdansk, Poland.
authors.forename: Michał
authors.initials: M
authors.lastname: Sawczyn
authors.affiliation: Gdansk University of Physical Education and Sport, Faculty of Tourism and Recreation, Gdansk, Poland.
authors.forename: Izabela
authors.initials: I
authors.lastname: Kozakiewicz-Drobnik
authors.affiliation: University of Szczecin, Faculty of Physical Education and Health Promotion, Szczecin, Poland.
authors.forename: Agata
authors.initials: A
authors.lastname: Leońska-Duniec
authors.affiliation: Gdansk University of Physical Education and Sport, Faculty of Tourism and Recreation, Gdansk, Poland.
authors.forename: Mariusz
authors.initials: M
authors.lastname: Kaczmarczyk
authors.affiliation: University of Szczecin, Faculty of Physical Education and Health Promotion, Szczecin, Poland; Institute of Sport, Warsaw, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Maciejewska-Skrendo
authors.affiliation: Institute of Sport, Warsaw, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Żmijewski
authors.affiliation: Department of Oral Surgery, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Trybek
authors.affiliation: Clinical Department of Laryngology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Smółka
authors.affiliation: Department of Anatomy and Antropology, Academy of Physical Education in Katowice, Poland.
authors.forename: Jan
authors.initials: J
authors.lastname: Pilch
authors.affiliation: University of Szczecin, Faculty of Physical Education and Health Promotion, Szczecin, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Leźnicka
authors.affiliation: Institute of Sport, Warsaw, Poland.
authors.forename: Ewelina
authors.initials: E
authors.lastname: Lulińska-Kuklik
authors.affiliation: University of Szczecin, Faculty of Physical Education and Health Promotion, Szczecin, Poland; Gdansk University of Physical Education and Sport, Faculty of Tourism and Recreation, Gdansk, Poland.
authors.forename: Marek
authors.initials: M
authors.lastname: Sawczuk
authors.affiliation: Department of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy.
authors.forename: Myosotis
authors.initials: M
authors.lastname: Massidda
keywords: MTHFR; exercise training; gene polymorphism