title: Effect of Local Rosuvastatin Administration on Calvarial Bone Defects.
abstract: The purpose of this study is to investigate the potential of the local administration of different doses of rosuvastatin (RSV) on autogenous grafted critical-sized cortical bone defects. Twenty-four rats were divided into 3 groups: Group C (control), Group RSV-0.1, and Group RSV-1. A 5-mm diameter critical-size defect was created in the calvarium of each animal. In Group C, the defect was filled by autogenous graft and sterile saline-treated absorbable collagen sponge (ACS) was applied. Defects in the experimental groups (groups RSV-0.1 and RSV-1) were grafted by autogenous graft and ACS with saline solution containing 0.1- and 1-mg RSV were applied. All animals were euthanized at 28 days after operation. Stereologic and micro-computed tomography (μCT) analyses were performed. New bone area and connective tissue volumes were measured. Stereologic analysis showed that the difference between group RSV-1 with a mean bone formation of 1.79 ± 0.06 mm and groups RSV-0.1 and control (C) was statistically significant (P ≤ 0.05) with a mean bone formation of 1.29 ± 0.28 mm and 1.08 ± 0.12 mm, respectively. Connective tissue volume was also significantly higher in 1-mg RSV applicated group. Micro-CT results were similar with stereologic analyses. Local administered 1-mg RSV enhances bone regeneration in critical-size calvarial rat defects filled with autogenous graft.
authors.affiliation: *Departments of Maxillofacial Surgery†Periodontology, Bülent Ecevit University, Zonguldak‡Department of Histology and Embryology, Ondokuz Mayis University, Samsun§Department of Anatomy, Hacettepe University, Ankara, Turkey.
authors.forename: Akif
authors.initials: A
authors.lastname: Türer
authors.forename: Çiğdem C
authors.initials: ÇC
authors.lastname: Türer
authors.forename: Umut
authors.initials: U
authors.lastname: Balli
authors.forename: Mustafa C
authors.initials: MC
authors.lastname: Durmuşlar
authors.forename: Mehmet E
authors.initials: ME
authors.lastname: Önger
authors.forename: Hakan H
authors.initials: HH
authors.lastname: Çelik
mesh_terms: D000818:Animals; D064592:Autografts; D001861:Bone Regeneration / Q000187:drug effects*; D016025:Bone Transplantation / Q000379:methods*; D004195:Disease Models, Animal; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage; D051381:Rats; D017208:Rats, Wistar; D000068718:Rosuvastatin Calcium / Q000008:administration & dosage*; D012886:Skull / Q000293:injuries / Q000601:surgery*; D055114:X-Ray Microtomography
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D000068718:Rosuvastatin Calcium