title: 17q21 locus rs7216389 polymorphism and childhood asthma risk: a meta-analysis.
abstract: BACKGROUND
  Recently, a genome-wide association study (GWAS) indicated that rs7216389 polymorphism on chromosome 17q21 was associated with paediatric asthma risk. However, the results remained controversial. Therefore, a meta-analysis was performed.
  
  
  METHODS
  A comprehensive literature retrieve was performed on PubMed, Embase and Science Direct databases up to Feb 20, 2016. The strength of association between 17q21 locus rs7216389 polymorphism and pediatric asthma risk was assessed by computing odds ratio (OR) with its corresponding 95% confidence interval (CI).
  
  
  RESULTS
  A total of 10 studies with 7797 cases and 38757 controls were included. A statistically significant association of rs7216389 polymorphism and pediatric asthma risk was found (OR=1.41, 95%CI=1.34-1.49, P<0.00001). Furthermore, both Caucasians (OR=1.41, 95%CI=1.33-1.49, P<0.00001) and Asians (OR=1.43, 95%CI=1.25-1.63, P<0.00001) with rs7216389 polymorphism showed significant association, respectively. A significantly increased susceptibility was identified in atopic asthma (OR=1.45, 95%CI=1.22-1.72, P<0.00001). In the stratification analysis by study design, both case-control studies (OR=1.40, 95%CI=1.33-1.48, P<0.00001) and cohort studies (OR=2.05, 95%CI=1.32-3.17, P=0.001) showed significant association, respectively.
  
  
  CONCLUSIONS
  In conclusion, this meta-analysis suggests that 17q21 locus rs7216389 polymorphism was significantly associated with paediatric asthma risk.
authors.affiliation: Department of Anesthesiology, No 401 Hospital of People's Liberation Army of China, Qingdao, China.
authors.forename: Yan-Liang
authors.initials: YL
authors.lastname: Qu
authors.affiliation: Department of Anesthesiology, No 401 Hospital of People's Liberation Army of China, Qingdao, China.
authors.forename: You-Ran
authors.initials: YR
authors.lastname: Ji
authors.affiliation: Department of Anesthesiology, No 401 Hospital of People's Liberation Army of China, Qingdao, China.
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: Zhang
authors.affiliation: Department of Anesthesiology, No 401 Hospital of People's Liberation Army of China, Qingdao, China.
authors.forename: Chun-Min
authors.initials: CM
authors.lastname: Wu
authors.affiliation: Department of Anesthesiology, No 401 Hospital of People's Liberation Army of China, Qingdao, China.
authors.forename: Bao-Lei
authors.initials: BL
authors.lastname: Wen
authors.affiliation: Department of Anesthesiology, No 401 Hospital of People's Liberation Army of China, Qingdao, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Anesthesiology, No 401 Hospital of People's Liberation Army of China, Qingdao, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Ma
authors.affiliation: Department of Anesthesiology, No 401 Hospital of People's Liberation Army of China, Qingdao, China.
authors.forename: De-Ming
authors.initials: DM
authors.lastname: Wang
authors.affiliation: Department of Anesthesiology, No 401 Hospital of People's Liberation Army of China, Qingdao, China.
authors.forename: Yuan-Xin
authors.initials: YX
authors.lastname: Zhang
authors.affiliation: Department of Anesthesiology, Wuhan General Hospital of People's Liberation Army of China, Wuhan, Hubei, China - zhouxiangwh@163.com.
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhou
mesh_terms: D044466:Asian People / Q000235:genetics; D001249:Asthma / Q000453:epidemiology / Q000235:genetics*; D002648:Child; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D011110:Polymorphism, Genetic; D012307:Risk Factors; D044465:White People / Q000235:genetics