title: Multimodal Magnetic Resonance and Near-Infrared-Fluorescent Imaging of Intraperitoneal Ovarian Cancer Using a Dual-Mode-Dual-Gadolinium Liposomal Contrast Agent.
abstract: The degree of tumor removal at surgery is a major factor in predicting outcome for ovarian cancer. A single multimodality agent that can be used with magnetic resonance (MR) for staging and pre-surgical planning, and with optical imaging to aid surgical removal of tumors, would present a new paradigm for ovarian cancer. We assessed whether a dual-mode, dual-Gadolinium (DM-Dual-Gd-ICG) contrast agent can be used to visualize ovarian tumors in the peritoneal cavity by multimodal MR and near infra-red imaging (NIR). Intraperitoneal ovarian tumors (Hey-A8 or OVCAR3) in mice enhanced on MR two days after intravenous DM-Dual Gd-ICG injection compared to controls (SNR, CNR, p < 0.05, n = 6). As seen on open abdomen and excised tumors views and confirmed by optical radiant efficiency measurement, Hey-A8 or OVCAR3 tumors from animals injected with DM-Dual Gd-ICG had increased fluorescence (p < 0.05, n = 6). This suggests clinical potential to localize ovarian tumors by MR for staging and surgical planning, and, by NIR at surgery for resection.
authors.affiliation: Department of Cancer Systems Imaging, U.T.-M.D. Anderson Cancer Center, 1400 Pressler St., Unit 1473, Houston, TX 77030, USA.
authors.forename: M K
authors.initials: MK
authors.lastname: Ravoori
authors.affiliation: Department of Cancer Systems Imaging, U.T.-M.D. Anderson Cancer Center, 1400 Pressler St., Unit 1473, Houston, TX 77030, USA.
authors.forename: S
authors.initials: S
authors.lastname: Singh
authors.affiliation: Department of Pediatric Radiology, Texas Children's Hospital, 6621 Fannin St., Houston, TX 77030, USA.
authors.forename: R
authors.initials: R
authors.lastname: Bhavane
authors.affiliation: Department of Gynecologic Oncology, U.T.-M.D. Anderson Cancer Center, 1400 Pressler St., Houston, TX 77030, USA.
authors.forename: A K
authors.initials: AK
authors.lastname: Sood
authors.affiliation: Department of Bioengineering, University of California, Riverside, 900 University Ave., 211 Materials Science &Engineering Building, Riverside, California, USA.
authors.forename: B
authors.initials: B
authors.lastname: Anvari
authors.affiliation: Department of Imaging Physics, U.T.-M.D. Anderson Cancer Center, 1400 Pressler St., Houston, TX 77030, USA.
authors.forename: J
authors.initials: J
authors.lastname: Bankson
authors.affiliation: Department of Pediatric Radiology, Texas Children's Hospital, 6621 Fannin St., Houston, TX 77030, USA.
authors.forename: A
authors.initials: A
authors.lastname: Annapragada
authors.affiliation: Department of Cancer Systems Imaging, U.T.-M.D. Anderson Cancer Center, 1400 Pressler St., Unit 1473, Houston, TX 77030, USA.|Department of Radiology, U.T.-M.D. Anderson Cancer Center, 1400 Pressler St., Houston, TX 77030, USA.
authors.forename: V
authors.initials: V
authors.lastname: Kundra
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000494:pharmacology*; D005260:Female; D005682:Gadolinium / Q000494:pharmacology*; D006801:Humans; D008081:Liposomes; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D008819:Mice, Nude; D064847:Multimodal Imaging / Q000379:methods*; D061848:Optical Imaging / Q000379:methods*; D010051:Ovarian Neoplasms / Q000000981:diagnostic imaging*
chemical_list: D003287:Contrast Media; D008081:Liposomes; D005682:Gadolinium