title: Elimination of Ventricular Arrhythmia in Catecholaminergic Polymorphic Ventricular Tachycardia by Targeting "Catecholamine-Sensitive Area": A Dominant-Subordinate Relationship between Origin Sites of Bidirectional Ventricular Premature Contractions.
abstract: We report on a patient diagnosed with catechoaminergic polymorphic ventricular tachycardia (CPVT) who underwent catheter ablation of ventricular premature contractions (VPCs) induced by epinephrine. VPCs were classified roughly into three types. Type 1 and Type 2 VPCs (right bundle branch block [RBBB] configuration and inferior axis) were eliminated by radiofrequency applications at the left aortic sinus of Valsalva and the anterolateral papillary muscle (APM), respectively. Although no spontaneous VPCs were seen after the elimination of Type 1 and 2 VPCs, pacing resulting in capture at the APM induced Type 3 VPC (RBBB configuration and superior axis) reproducibly. The electrophysiological findings observed in our representative case have important implications both for understanding the pathophysiology of CPVT and for considering therapeutic strategies.
authors.affiliation: Heart Rhythm Center, Tokyo Medical and Dental University Hospital, Tokyo, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Shirai
authors.affiliation: Heart Rhythm Center, Tokyo Medical and Dental University Hospital, Tokyo, Japan.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Goya
authors.affiliation: Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Shiga, Japan.
authors.forename: Seiko
authors.initials: S
authors.lastname: Ohno
authors.affiliation: Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Shiga, Japan.
authors.forename: Minoru
authors.initials: M
authors.lastname: Horie
authors.affiliation: Department of Pediatrics, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Shozaburo
authors.initials: S
authors.lastname: Doi
authors.affiliation: Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Mitsuaki
authors.initials: M
authors.lastname: Isobe
authors.affiliation: Heart Rhythm Center, Tokyo Medical and Dental University Hospital, Tokyo, Japan.
authors.forename: Kenzo
authors.initials: K
authors.lastname: Hirao
mesh_terms: D000328:Adult; D002037:Bundle-Branch Block / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D017115:Catheter Ablation / Q000379:methods*; D005260:Female; D006329:Heart Conduction System / Q000601:surgery; D006801:Humans; D017180:Tachycardia, Ventricular / Q000150:complications* / Q000175:diagnosis / Q000601:surgery*; D016896:Treatment Outcome; D018879:Ventricular Premature Complexes / Q000150:complications* / Q000175:diagnosis / Q000601:surgery*; D000098850:Polymorphic Catecholaminergic Ventricular Tachycardia
keywords: bidirectional ventricular premature contraction; catecholaminergic polymorphic ventricular tachycardia; catheter ablation