title: Three new xanthones from Swertia bimaculata and their anti-5α-reductase activity.
abstract: Three new xanthones (1-3), together with five known ones (4-8), were isolated from whole herb of Swertia bimaculata. Their structures were established on the basis of detailed spectroscopic analysis (1D- and 2D-NMR, HRESIMS, UV, and IR) and comparison with data reported in the literature. New isolates were evaluated for their anti-5α-reductase activity. The results revealed that all new compounds showed weak activity with reductase inhibitions of 40.5 ± 2.8, 38.6 ± 2.5, and 48.9 ± 3.0%, respectively.
authors.affiliation: a Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education , Yunnan Minzu University , Kunming 650500 , China.
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Wu
authors.affiliation: a Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education , Yunnan Minzu University , Kunming 650500 , China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Sheng
authors.affiliation: a Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education , Yunnan Minzu University , Kunming 650500 , China.
authors.forename: Xue-Qin
authors.initials: XQ
authors.lastname: Kan
authors.affiliation: a Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education , Yunnan Minzu University , Kunming 650500 , China.
authors.forename: Lin-Yun
authors.initials: LY
authors.lastname: Mou
authors.affiliation: a Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education , Yunnan Minzu University , Kunming 650500 , China.
authors.forename: Qiu-Feng
authors.initials: QF
authors.lastname: Hu
authors.affiliation: a Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education , Yunnan Minzu University , Kunming 650500 , China.
authors.forename: Gan-Peng
authors.initials: GP
authors.lastname: Li
mesh_terms: D058891:5-alpha Reductase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D029967:Swertia / Q000737:chemistry*; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D058891:5-alpha Reductase Inhibitors; D004365:Drugs, Chinese Herbal; D044004:Xanthones
keywords: Gentianaceae; Swertia bimaculata; anti-5α-reductase activity; xanthones