title: Recycling to discover something new: the role of autophagy in kidney disease.
abstract: This year, the Nobel Prize in Physiology or Medicine was awarded to Yoshinori Ohsumi for his groundbreaking work in dissecting the mechanisms of autophagy, a cellular process resulting in the organized degradation of cytoplasmic components. Ohsumi's work paved the way for subsequent studies that demonstrated critical roles for autophagy in modulating both acute and chronic kidney injury. This work may lead to future therapeutic approaches that target the autophagy system to prevent or treat kidney diseases.
authors.affiliation: Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, USA; Renal Division, James J. Peters Bronx VA Medical Center, Bronx, New York, USA. Electronic address: Jeremy.leventhal@mssm.edu.
authors.forename: Jeremy S
authors.initials: JS
authors.lastname: Leventhal
authors.affiliation: Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, USA.
authors.forename: Christina M
authors.initials: CM
authors.lastname: Wyatt
authors.affiliation: Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, USA; Renal Division, James J. Peters Bronx VA Medical Center, Bronx, New York, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Ross
mesh_terms: D001343:Autophagy / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D006801:Humans; D007668:Kidney / Q000473:pathology*; D009613:Nobel Prize; D010827:Physiology; D051436:Renal Insufficiency, Chronic / Q000473:pathology / Q000503:physiopathology*