title: Complication and surgical site infection for salvage surgery in head and neck cancer after chemoradiotherapy and bioradiotherapy.
abstract: OBJECTIVE
  We aimed to investigate the complications, surgical site infection (SSI), and survival in salvage surgery without free-flap reconstruction for patients with head and neck squamous cell carcinoma who were treated by platinum-based chemoradiotherapy (Plat-CRT) or cetuximab-based bioradiotherapy (Cet-BRT).
  
  
  METHODS
  Thirty-three patients treated by Plat-CRT and six treated by Cet-BRT had salvage surgery. We categorized postoperative complications according to the Clavien-Dindo classification and SSI according to the wound grading scale. Overall survival calculated by Kaplan-Meier method.
  
  
  RESULTS
  Patients with Cet-BRT were significantly associated with the presence of SSI (P<0.01) and grades IIIb-V of the Clavien-Dindo classification (P<0.01) compared with those with Plat-CRT. Patients with Cet-BRT had a significantly lower overall survival than those with Plat-CRT (P<0.05).
  
  
  CONCLUSIONS
  We demonstrated that patients with Cet-BRT were significantly more associated with the presence of SSI and grades IIIb-V in the Clavien-Dindo classification than those with CRT.
authors.affiliation: Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya, Japan. Electronic address: hi.suzuki@aichi-cc.jp.
authors.forename: Hidenori
authors.initials: H
authors.lastname: Suzuki
authors.affiliation: Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya, Japan.
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Hanai
authors.affiliation: Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Nishikawa
authors.affiliation: Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya, Japan.
authors.forename: Yujiro
authors.initials: Y
authors.lastname: Fukuda
authors.affiliation: Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya, Japan.
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Hasegawa
mesh_terms: D000368:Aged; D000074322:Antineoplastic Agents, Immunological / Q000008:administration & dosage; D000068818:Cetuximab / Q000008:administration & dosage; D059248:Chemoradiotherapy; D005260:Female; D006258:Head and Neck Neoplasms / Q000401:mortality / Q000628:therapy*; D006801:Humans; D007825:Laryngectomy; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection; D016879:Salvage Therapy / Q000009:adverse effects*; D013530:Surgical Wound Infection / Q000145:classification / Q000209:etiology*
chemical_list: D000074322:Antineoplastic Agents, Immunological; D000068818:Cetuximab
keywords: Bioradiotherapy; Chemoradiotherapy; Complication; Head and neck squamous cell carcinoma; Salvage surgery