title: Clinical efficacy of a 1% Matricaria chamomile L. mouthwash and 0.12% chlorhexidine for gingivitis control in patients undergoing orthodontic treatment with fixed appliances.
abstract: This pilot study evaluated the clinical efficacy of a mouthwash containing 1% Matricaria chamomilla L. (MTC) extract in reducing gingival inflammation and plaque formation in patients undergoing orthodontic treatment with fixed appliances. This randomized, double-blind, placebo-controlled study enrolled a total of 30 males and females (age, 10-40 years) with fixed orthodontic appliances and a minimum of 20 natural teeth. The participants were allocated to three groups (n = 10 each) and asked to rinse with 15 mL of a placebo, 0.12% chlorhexidine (CHX), or 1% MTC mouthwash, immediately after brushing for 1 min, in the morning and evening, for 15 days. Data (mean ± SD) on visible plaque index (VPI) and gingival bleeding index (GBI) were recorded on days 1 and 15. The placebo group exhibited increases in VPI and GBI (10.2% and 23.1%, respectively) from day 1 to day 15. As compared with placebo, VPI and GBI significantly decreased in the MTC group (-25.6% and -29.9%, respectively) and the CHX group (-39.9% and -32.0%, respectively). In summary, MTC reduced biofilm accumulation and gingival bleeding in patients with gingivitis, probably because of its antimicrobial and anti-inflammatory activities.(J Oral Sci 58, 569-574, 2016).
authors.affiliation: Department of Pathology and Legal Medicine, Federal University of Ceará.
authors.forename: Paula
authors.initials: P
authors.lastname: Goes
authors.forename: Caio S
authors.initials: CS
authors.lastname: Dutra
authors.forename: Mário R P
authors.initials: MR
authors.lastname: Lisboa
authors.forename: Delane V
authors.initials: DV
authors.lastname: Gondim
authors.forename: Renata
authors.initials: R
authors.lastname: Leitão
authors.forename: Gerly A C
authors.initials: GA
authors.lastname: Brito
authors.forename: Rodrigo O
authors.initials: RO
authors.lastname: Rego
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002710:Chlorhexidine / Q000008:administration & dosage*; D004311:Double-Blind Method; D005260:Female; D005891:Gingivitis / Q000517:prevention & control*; D006801:Humans; D008297:Male; D031168:Matricaria / Q000737:chemistry*; D009067:Mouthwashes; D009967:Orthodontic Appliances; D010919:Placebos; D010936:Plant Extracts / Q000008:administration & dosage*; D055815:Young Adult
chemical_list: D009067:Mouthwashes; D010919:Placebos; D010936:Plant Extracts; D002710:Chlorhexidine