title: Emergence of miR-34a in radiation therapy.
abstract: Expressions of many microRNAs (miRNAs) in response to ionizing radiation (IR) have already been investigated and some of them seem to play an important role in the tumor radioresistance, normal tissue radiotoxicity or as predictive biomarkers to radiation. miR-34a is an emerging miRNA in recent radiobiology studies. Here, we review this miR-34 family member by detailing its different roles in radiation response and we will discuss about the role that it can play in radiation treatment. Thus, we will show that IR regulates miR-34a by increasing its expression. We will also highlight different biological processes involved in cellular response to IR and regulated by miR-34a in order to demonstrate the role it can play in tumor radio-response or normal tissue radiotoxicity as a radiosensitizer or radioprotector. miR-34a is poised to assert itself as an important player in radiobiology and should become more and more important in radiation therapy management.
authors.affiliation: Center for Applied NanoBioscience and Medicine, University of Arizona, 145 S. 79th Street, Chandler, AZ 85226, USA. Electronic address: jlacombe@email.arizona.edu.
authors.forename: Jerome
authors.initials: J
authors.lastname: Lacombe
authors.affiliation: Center for Applied NanoBioscience and Medicine, University of Arizona, 145 S. 79th Street, Chandler, AZ 85226, USA; Translational Genomics Research Institute, 445 N. Fifth Street, Phoenix, AZ 85004, USA; Department of Basic Medical Sciences, College of Medicine Phoenix, 425 N. 5th Street, Phoenix, AZ 85004, USA. Electronic address: fzenhaus@email.arizona.edu.
authors.forename: Frederic
authors.initials: F
authors.lastname: Zenhausern
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D006801:Humans; D035683:MicroRNAs / Q000096:biosynthesis* / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics* / Q000532:radiotherapy*; D011836:Radiation Tolerance; D011839:Radiation, Ionizing
chemical_list: D035683:MicroRNAs
keywords: Biodosimetry; Biomarkers; Ionizing radiation; Oncology; Radiotherapy; Radiotoxicity; miR-34a