title: [The effect of palonosetron on rocuronium-induced withdrawal movement].
abstract: BACKGROUND
  Rocuronium causes pain and withdrawal movement during induction of anesthesia. In this study, palonosetron was investigated to have analgesic effect on the reduction of rocuronium-induced withdrawal movement.
  
  
  METHODS
  120 patients were randomly assigned to one of three groups to receive either saline, lidocaine 20mg, or palonosetron 0.075mg with a tourniquet applied two minutes before thiopental sodium (5mg.kg-1) was given intravenously. After loss of consciousness, rocuronium (0.6mg.kg-1) was injected and the withdrawal movement was estimated by 4-point scale in a double-blind manner.
  
  
  RESULTS
  The overall incidence of rocuronium withdrawal movement was 50% with lidocaine (p=0.038), 38% with palonosetron (p=0.006) compared with 75% for saline. The incidence of no pain to mild pain was significantly lower in the lidocaine and palonosetron groups (85% and 92% respectively) than in the saline group (58%). However, there was no significant difference in withdrawal movement between the lidocaine and palonosetron groups. There was no severe movement with palonosetron.
  
  
  CONCLUSIONS
  Pretreatment of palonosetron with venous occlusion may attenuate rocuronium-induced withdrawal movement as effective as the use of lidocaine. It suggested that peripheral action of palonosetron was effective to reduce rocuronium-induced withdrawal movement.
authors.affiliation: Keimyoung University, School of Medicine, Department of Anesthesiology and Pain Medicine, Daegu, República da Coreia.
authors.forename: Ki-Bum
authors.initials: KB
authors.lastname: Park
authors.affiliation: Kyungpook National University, School of Dentistry, Department of Anesthesiology, Daegu, República da Coreia.
authors.forename: Younghoon
authors.initials: Y
authors.lastname: Jeon
authors.affiliation: Kyungpook National University, School of Medicine, Department of Anesthesiology and Pain Medicine, Daegu, República da Coreia.
authors.forename: Junggu
authors.initials: J
authors.lastname: Yi
authors.affiliation: Kyungpook National University, School of Medicine, Department of Anesthesiology and Pain Medicine, Daegu, República da Coreia.
authors.forename: Ji-Hyun
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Kyungpook National University, School of Medicine, Department of Anesthesiology and Pain Medicine, Daegu, República da Coreia.
authors.forename: Seung-Yeon
authors.initials: SY
authors.lastname: Chung
authors.affiliation: Kyungpook National University, School of Medicine, Department of Anesthesiology and Pain Medicine, Daegu, República da Coreia. Electronic address: kwakkh@knu.ac.kr.
authors.forename: Kyung-Hwa
authors.initials: KH
authors.lastname: Kwak
mesh_terms: D000328:Adult; D000368:Aged; D004311:Double-Blind Method; D006801:Humans; D008875:Middle Aged; D009068:Movement / Q000187:drug effects*; D003473:Neuromuscular Nondepolarizing Agents / Q000009:adverse effects*; D000077924:Palonosetron / Q000627:therapeutic use*; D011446:Prospective Studies; D000077123:Rocuronium / Q000009:adverse effects*; D058831:Serotonin 5-HT3 Receptor Antagonists / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D003473:Neuromuscular Nondepolarizing Agents; D058831:Serotonin 5-HT3 Receptor Antagonists; D000077924:Palonosetron; D000077123:Rocuronium
keywords: Dor; Injection; Injeção; Pain; Palonosetron; Reflexo de retirada; Rocuronium; Rocurônio; Withdrawal movement