title: Validation of the italian version of the 15-item Myasthenia Gravis Quality-of-Life questionnaire.
abstract: BACKGROUND
  In this study we assess the Italian version of the 15-item Myasthenia Gravis Quality-of-Life questionnaire (MG-QOL15).
  
  
  METHODS
  The validation protocol included the MG-QOL15, the 36-item Short Form (SF-36), the Besta Neurological Institute Rating Scale for Myasthenia Gravis, and the MG-Composite. We used the Cronbach α to test reliability, the Spearman correlation to test short-term test-retest, the Kruskal-Wallis test to assess differences in MG-QOL15 between patients with different disease severity, and the Wilcoxon signed-rank test to assess sensitivity to change.
  
  
  RESULTS
  Seventy-two patients were enrolled in the study. The mean MG-QOL15 score was 15.2 ± 12.2, with α = 0.93 and test-retest correlation = 0.93. Compared with the SF-36, the MG-QOL15 was superior in differentiating patients with different MG types (P = 0.041) and severity (P = 0.004), showed higher sensitivity to change (P = 0.003 for improved and P = 0.024 for worsened patients), and had higher correlations with the MG-Composite (rho = 0.367 vs. -0.213 and -0.154).
  
  
  CONCLUSIONS
  The Italian version of the MG-QOL15 is valid, reliable, stable, and sensitive to changes. Muscle Nerve 56: 716-720, 2017.
authors.affiliation: Neurology, Public Health and Disability Unit, Neurological Institute C. Besta IRCCS Foundation, Via Celoria 11, 20133, Milan, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Raggi
authors.affiliation: Neurology, Public Health and Disability Unit, Neurological Institute C. Besta IRCCS Foundation, Via Celoria 11, 20133, Milan, Italy.
authors.forename: Matilde
authors.initials: M
authors.lastname: Leonardi
authors.affiliation: Neurology, Public Health and Disability Unit, Neurological Institute C. Besta IRCCS Foundation, Via Celoria 11, 20133, Milan, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Ayadi
authors.affiliation: Department of Neuroimmunology and Neuromuscular Disorders, Neurological Institute C. Besta IRCCS Foundation, Milan, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Antozzi
authors.affiliation: Department of Neuroimmunology and Neuromuscular Disorders, Neurological Institute C. Besta IRCCS Foundation, Milan, Italy.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Maggi
authors.affiliation: Department of Neuroimmunology and Neuromuscular Disorders, Neurological Institute C. Besta IRCCS Foundation, Milan, Italy.
authors.forename: Fulvio
authors.initials: F
authors.lastname: Baggi
authors.affiliation: Department of Neuroimmunology and Neuromuscular Disorders, Neurological Institute C. Besta IRCCS Foundation, Milan, Italy.
authors.forename: Renato
authors.initials: R
authors.lastname: Mantegazza
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006306:Health Surveys / Q000379:methods / Q000592:standards*; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology*; D011788:Quality of Life / Q000523:psychology; D011795:Surveys and Questionnaires / Q000592:standards*; D014175:Translating
keywords: INCB-MG; MG-QOL15; SF-36; myasthenia gravis; reliability; validity