title: [Significance of PSMA imaging in prostate cancer].
abstract: BACKGROUND
  Prostate cancer (PCa) is one of the most common malignancies of men in developed countries. To improve clinical diagnostics of PCa,68Ga-PSMA-11 was recently introduced as a new PET tracer.68Ga-PSMA-11 is able to specifically bind to the prostate-specific membrane antigen (PSMA), which is upregulated on the surface of prostate cancer cells in most patients.
  
  
  OBJECTIVE
  To analyse the current significance of68Ga-PSMA-11 PET imaging in prostate cancer in relation to staging of men with initial diagnosis, biochemical recurrence and metastatic disease.
  
  
  METHODS
  Retrospective analysis of current literature (PubMed search) regarding68Ga-PSMA-11 PET diagnostics in primary staging, in biochemical recurrence and in metastasized disease.
  
  
  RESULTS
  Compared to conventional imaging,68Ga-PSMA-11 PET/CT reaches a higher sensitivity with an excellent specificity in the clinical diagnosis of primary staging as well as staging for recurrence and advanced, metastasized disease. In biochemical recurrence,68Ga-PSMA-11 PET/CT shows significantly higher detection rates in comparison to choline PET/CT, especially in patients with low PSA values. In the clinical diagnosis of recurrent disease, therapy concepts were changed in more than a quarter of the patients due to the use of68Ga-PSMA-11 PET/CT. The significance of staging with68Ga-PSMA-11 PET/CT in advanced metastasized patients remains uncertain.
  
  
  CONCLUSIONS
  Due to the excellent results of68Ga-PSMA-11 PET imaging, even in patients with slightly elevated PSA levels, it will continue to play an important role in clinical diagnostics of prostate cancer and, thus, its clinical utilization will become more widely spread.
authors.affiliation: Urologische Klinik, Universitätsklinikum Heidelberg, Heidelberg, Deutschland.
authors.forename: C
authors.initials: C
authors.lastname: Gasch
authors.affiliation: Urologische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, München, Deutschland.
authors.forename: C
authors.initials: C
authors.lastname: Düwel
authors.affiliation: Abteilung Radiopharmazeutische Chemie, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Deutschland.
authors.forename: K
authors.initials: K
authors.lastname: Kopka
authors.affiliation: Abteilung Nuklearmedizin, Radiologische Klinik, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Deutschland.
authors.forename: C
authors.initials: C
authors.lastname: Kratochwil
authors.affiliation: Abteilung Nuklearmedizin, Radiologische Klinik, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Deutschland.
authors.forename: M
authors.initials: M
authors.lastname: Vinsensia
authors.affiliation: Nuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, München, Deutschland.
authors.forename: M
authors.initials: M
authors.lastname: Eiber
authors.affiliation: Urologische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, München, Deutschland.
authors.forename: T
authors.initials: T
authors.lastname: Maurer
authors.affiliation: Abteilung Nuklearmedizin, Radiologische Klinik, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Deutschland.
authors.forename: U
authors.initials: U
authors.lastname: Haberkorn
authors.affiliation: Urologische Klinik, Universitätsklinikum Heidelberg, Heidelberg, Deutschland.
authors.forename: B
authors.initials: B
authors.lastname: Hadaschik
authors.affiliation: Abteilung Nuklearmedizin, Radiologische Klinik, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Deutschland. frederik@egiesel.com.
authors.forename: F L
authors.initials: FL
authors.lastname: Giesel
mesh_terms: D004492:Edetic Acid / Q000031:analogs & derivatives; D019317:Evidence-Based Medicine; D005709:Gallium Isotopes; D005710:Gallium Radioisotopes; D006801:Humans; D008297:Male; D009842:Oligopeptides; D009942:Organometallic Compounds; D011467:Prostate / Q000000981:diagnostic imaging* / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D005709:Gallium Isotopes; D005710:Gallium Radioisotopes; D009842:Oligopeptides; D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; C000718244:gallium 68 PSMA-11; D004492:Edetic Acid
keywords: Biochemical ﻿recurrence; Multiparametric magnetic resonance imaging; Positron emission tomography; Prostate specific membrane antigen; Staging