title: On-demand drug release and hyperthermia therapy applications of thermoresponsive poly-(NIPAAm-co-HMAAm)/polyurethane core-shell nanofiber mat on non-vascular nitinol stents.
abstract: A functional cover made up of core-shell nanofibers with a unique combination of thermoresponsive polymeric shell and stretchable polymeric core for non-vascular nitinol stents that uses an alternating magnetic field (AMF) to induce heat in the stent for hyperthermia therapy and simultaneously release 5-fluorouracil and/or paclitaxel was designed. Varying the ratios of NIPAAm to HMAAm monomer resulted in different LCST properties for the synthesized copolymer and further utilized for an on-demand drug release. Biocompatibility test using NIH-3T3 fibroblast cells indicates that the composite with drug content is biocompatible and the in-vitro cancer cytotoxicity test using ESO26 and OE21 cancer cells proved that the material shows cancer cytotoxic properties via combination of dual drug and hyperthermia therapy. With this functional material, we propose a tailorable and on-demand drug release with more control that can be employed for a combination drug therapy/single drug therapy combined with hyperthermia therapy for cancer cytotoxicity effect.
authors.affiliation: Department of Bionanosystem Engineering, Graduate School, Chonbuk National University, Republic of Korea.
authors.forename: Ludwig Erik
authors.initials: LE
authors.lastname: Aguilar
authors.affiliation: Department of Bionanosystem Engineering, Graduate School, Chonbuk National University, Republic of Korea.
authors.forename: Amin
authors.initials: A
authors.lastname: GhavamiNejad
authors.affiliation: Department of Bionanosystem Engineering, Graduate School, Chonbuk National University, Republic of Korea; Department of Mechanical Design Engineering, Chonbuk National University, Jeonju City, Republic of Korea.
authors.forename: Chan Hee
authors.initials: CH
authors.lastname: Park
authors.affiliation: Department of Bionanosystem Engineering, Graduate School, Chonbuk National University, Republic of Korea; Department of Mechanical Design Engineering, Chonbuk National University, Jeonju City, Republic of Korea; Eco-friendly Machine Parts Design Research Center, Chonbuk National University, Jeonju City, Republic of Korea. Electronic address: chskim@jbnu.ac.kr.
authors.forename: Cheol Sang
authors.initials: CS
authors.lastname: Kim
mesh_terms: D065546:Drug Liberation; D005347:Fibroblasts; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D057139:Nanofibers; D011108:Polymers; D011140:Polyurethanes; D015607:Stents; D013696:Temperature; D014407:Tumor Cells, Cultured
chemical_list: D011108:Polymers; D011140:Polyurethanes
keywords: Chemotherapy; Core-shell nanofibers; Drug eluting stents (DES); Hyperthermia; Lower critical solution temperature (LCST); Thermoresponsive polymers