title: Association between alpha-adducin gene rs4963 polymorphism and hypertension risk in Asian population: a meta-analysis.
abstract: Some studies investigated the association between ADD1 rs4963 polymorphism and hypertension risk. However, the results remained inconclusive. Thus, we performed a meta-analysis. Published reports were searched in PubMed and Google Scholar. The strength of association was assessed by calculating odds ratios (OR) and 95% confidence interval (CI). Twelve studies with 5097 cases and 5937 controls were conducted in this study. Individuals with ADD1 rs4963 polymorphism showed an increased hypertension risk (OR = 1.21; 95%CI, 1.11-1.33; P &lt; 0.0001). Subgroup analyses were performed according to country and age. The results showed that Chinese with ADD1 rs4963 polymorphism showed an increased hypertension risk (OR = 1.28; 95%CI, 1.09-1.51; P = 0.003). However, subjects in Japan and India did not have increased hypertension risk. In the subgroup analysis by age, older subjects, but not younger subjects, with ADD1 rs4963 polymorphism showed an increased hypertension risk (OR = 1.19; 95%CI, 1.07-1.32; P = 0.001). In conclusion, this meta-analysis suggested that ADD1 rs4963 polymorphism might be associated with increased hypertension risk.
authors.affiliation: Department of Anesthesiology, No. 401 Hospital of PLA, Qingdao, China.
authors.forename: Y-L
authors.initials: YL
authors.lastname: Qu
authors.affiliation: Department of Anesthesiology, No. 401 Hospital of PLA, Qingdao, China.
authors.forename: C-M
authors.initials: CM
authors.lastname: Wu
authors.affiliation: Department of Anesthesiology, No. 401 Hospital of PLA, Qingdao, China.
authors.forename: L-X
authors.initials: LX
authors.lastname: Zhang
authors.affiliation: Department of Anesthesiology, No. 401 Hospital of PLA, Qingdao, China.
authors.forename: B-L
authors.initials: BL
authors.lastname: Wen
authors.affiliation: Department of Anesthesiology, No. 401 Hospital of PLA, Qingdao, China.
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Anesthesiology, No. 401 Hospital of PLA, Qingdao, China.
authors.forename: C
authors.initials: C
authors.lastname: Ma
authors.affiliation: Department of Anesthesiology, No. 401 Hospital of PLA, Qingdao, China.
authors.forename: X-Y
authors.initials: XY
authors.lastname: Yan
authors.affiliation: Emergency Department, Qilu Hospital of Shandong University, Qingdao, China.
authors.forename: H-B
authors.initials: HB
authors.lastname: Cui
authors.affiliation: Department of Anesthesiology, No. 401 Hospital of PLA, Qingdao, China.
authors.forename: D-M
authors.initials: DM
authors.lastname: Wang
authors.affiliation: Department of Medical Affairs, No. 401 Hospital of PLA, Qingdao, China.
authors.forename: Y-R
authors.initials: YR
authors.lastname: Ji
mesh_terms: D000367:Age Factors; D044466:Asian People / Q000235:genetics*; D002148:Calmodulin-Binding Proteins / Q000235:genetics*; D016208:Databases, Factual; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000235:genetics* / Q000473:pathology; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D000099291:Adducins
chemical_list: D002148:Calmodulin-Binding Proteins; D000099291:Adducins