title: Naringin alleviates early brain injury after experimental subarachnoid hemorrhage by reducing oxidative stress and inhibiting apoptosis.
abstract: This study aims to clarify the neuroprotective effect of naringin on early brain injury (EBI) following subarachnoid hemorrhage (SAH) and the possible mechanisms of naringin in the treatment of SAH. The endovascular puncture model was performed to induce SAH model in rats and the efficacy of 40mg/kg and 80mg/kg naringin were tested by intraperitoneally administration. SAH grade, neurological score, brain edema, blood-brain barrier permeability, the changes of oxidative stress related factors, apoptosis-related proteins, mitogen-activated protein kinase (MAPK) signaling pathway and neuronal morphology were detected to analyze the potential effect of naringin against SAH. The results demonstrated that naringin significantly ameliorated EBI, including SAH severity, neurologic deficits, brain edema and blood-brain barrier integrity by attenuating SAH-induced oxidative stress and apoptosis, and reduced the oxidant damage and apoptosis by inhibiting the activation of MAPK signaling pathway, which suggested a therapeutic potential of naringin in providing neuroprotection after SAH.
authors.affiliation: Institute of Neurology, General Hospital of Shenyang Military Command, Shenyang, Liaoning, 110016, China.
authors.forename: Yuwei
authors.initials: Y
authors.lastname: Han
authors.affiliation: Institute of Neurology, General Hospital of Shenyang Military Command, Shenyang, Liaoning, 110016, China.
authors.forename: Jingyuan
authors.initials: J
authors.lastname: Su
authors.affiliation: Institute of Neurology, General Hospital of Shenyang Military Command, Shenyang, Liaoning, 110016, China.
authors.forename: Xiujuan
authors.initials: X
authors.lastname: Liu
authors.affiliation: Institute of Neurology, General Hospital of Shenyang Military Command, Shenyang, Liaoning, 110016, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Institute of Neurology, General Hospital of Shenyang Military Command, Shenyang, Liaoning, 110016, China.
authors.forename: Chenchen
authors.initials: C
authors.lastname: Wang
authors.affiliation: Institute of Neurology, General Hospital of Shenyang Military Command, Shenyang, Liaoning, 110016, China. Electronic address: lxm5668sw@yahoo.com.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Li
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D051017:Apoptosis Regulatory Proteins / Q000378:metabolism; D001812:Blood-Brain Barrier / Q000187:drug effects; D001921:Brain / Q000378:metabolism; D001929:Brain Edema / Q000188:drug therapy; D001930:Brain Injuries / Q000188:drug therapy* / Q000517:prevention & control; D044950:Flavanones / Q000378:metabolism / Q000494:pharmacology*; D008297:Male; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D018696:Neuroprotective Agents / Q000494:pharmacology; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D015398:Signal Transduction / Q000187:drug effects; D013345:Subarachnoid Hemorrhage / Q000188:drug therapy*
chemical_list: D051017:Apoptosis Regulatory Proteins; D044950:Flavanones; D018696:Neuroprotective Agents; D020928:Mitogen-Activated Protein Kinases; C005274:naringin
keywords: Apoptosis; Early brain injury; Naringin; Oxidative stress; Subarachnoid hemorrhage