title: Microcephaly and arthrogryposis multiplex congenita: The full-blown CNS spectrum in newborns with ZIKV infection.
abstract: The recent alarming statements concerning the newborn ZIKV-induced microcephaly epidemics in the Northeast of Brazil, released by the Brazilian Ministry of Health, as well as important international health agencies, such as the World Health Organization and the Pan American Health Organization, raised many "why and how" questions so far, that will hopefully be scientifically answered, as more researches in that regard come up in the long term. In this paper, we describe another potentially ZIKV-induced central nervous system and musculoskeletal disorder that has accompanied microcephaly in these children: atrhogryposis multiplex congenita. The goal is to bring up some hypotheses for possible underlying molecular mechanisms based on published data taken from animal models, such as ovine and cattle, which once infected by other types of arboviroses and viruses that also belong to the Flaviviridae family, presented, too, with the full-blown CNS spectrum of malformations at birth.
authors.affiliation: Federal Fluminense University, Antônio Pedro University Hospital, 24033-900, Niterói, Rio de Janeiro, Brazil. Electronic address: marcioley@icloud.com.
authors.forename: Marcio
authors.initials: M
authors.lastname: Leyser
authors.affiliation: Federal Fluminense University, Antônio Pedro University Hospital, 24033-900, Niterói, Rio de Janeiro, Brazil.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Fernandes
authors.affiliation: Federal Fluminense University, Antônio Pedro University Hospital, 24033-900, Niterói, Rio de Janeiro, Brazil.
authors.forename: Pamela
authors.initials: P
authors.lastname: Passos
authors.affiliation: Federal Fluminense University, Antônio Pedro University Hospital, 24033-900, Niterói, Rio de Janeiro, Brazil.
authors.forename: Camila
authors.initials: C
authors.lastname: Pupe
authors.affiliation: Federal Fluminense University, Antônio Pedro University Hospital, 24033-900, Niterói, Rio de Janeiro, Brazil.
authors.forename: Andre Pc
authors.initials: AP
authors.lastname: Matta
authors.affiliation: Federal Fluminense University, Antônio Pedro University Hospital, 24033-900, Niterói, Rio de Janeiro, Brazil.
authors.forename: Marcio Moacyr
authors.initials: MM
authors.lastname: Vasconcelos
authors.affiliation: Federal Fluminense University, Antônio Pedro University Hospital, 24033-900, Niterói, Rio de Janeiro, Brazil.
authors.forename: Osvaldo Jm
authors.initials: OJ
authors.lastname: Nascimento
mesh_terms: D001176:Arthrogryposis / Q000209:etiology* / Q000821:virology; D002490:Central Nervous System / Q000473:pathology / Q000821:virology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008831:Microcephaly / Q000209:etiology* / Q000821:virology; D000071243:Zika Virus Infection / Q000150:complications* / Q000473:pathology*