title: Interleukin 17-expressing Innate Synovial Cells Drive K/Bxn Serum-induced Arthritis.
abstract: K/BxN serum can induce arthritis in normal mice because of abundant autoantibodies that trigger an innate inflammatory response in joints. To determine whether IL-17 is involved in the pathogenesis of serum-induced arthritis, we injected wild-type and IL-17-/-mice with K/BxN serum and evaluated them for signs of arthritis. Unlike wild-type mice, IL-17-/-mice did not show any signs of arthritis. IL-17 was produced predominantly by CD3-CD4-γδTCR-NK1.1-Sca1intThy1hicells residing in the inflamed synovial tissue. When synovial cells extracted from normal joints were stimulated with IL-23 or autoantibody-containing immune complexes, a substantial fraction of Sca1intThy1hicells produced IL-17. Thus, we have identified a novel population of IL-17-producing innate synovial cells that play a crucial role in the development of K/BxN serum-induced arthritis.
authors.affiliation: Department of Anatomy & Cell Biology, College of Medicine, Hanyang University, Seoul 04763, Korea.
authors.forename: Wang Shik
authors.initials: WS
authors.lastname: Cho
authors.affiliation: Department of Anatomy & Cell Biology, College of Medicine, Hanyang University, Seoul 04763, Korea.
authors.forename: Eunkyeong
authors.initials: E
authors.lastname: Jang
authors.affiliation: Konkuk University Medical Center, Seoul 05030, Korea.
authors.forename: Ho-Youn
authors.initials: HY
authors.lastname: Kim
authors.affiliation: Department of Anatomy & Cell Biology, College of Medicine, Hanyang University, Seoul 04763, Korea.
authors.forename: Jeehee
authors.initials: J
authors.lastname: Youn
keywords: Arthritis; IL-17; Immune complex; Synovial cells