title: Modification of radiation induced chromosome damage in Allium test by sodium humate.
abstract: OBJECTIVE
  Cytogenetic analysis of the effects of sodium humate in induced γ irradiation mutagenesis in Allium test.
  
  
  METHODS
  Analysis of the root meristem cells of Allium cepa L. seeds carried by ana telophase. Inves tigated the effect of sodium humate (100 mg/l) on cytogenetic effects γ irradiation (137Cs) at doses of 5, 10 and 20 Gy.
  
  
  RESULTS
  Antimutagenic effect of sodium humate was revealed, what allows to consider it as potential therapeutic modifier of radiation damage. Antimutagenic effect of sodium humate increased with increasing irradiation dose. Spotted differential activity of the drug with respect to various types of aberrations are most effectively reducing the frequency of radiation markers mutagenesis - chromosomal aberrations manifested in lower efficiency of long term survivors against potential changes of chromosomes compared with short lived.
  
  
  CONCLUSIONS
  Revealed different mechanisms for implementing antimutagenic properties of sodium humate in con dition of γ irradiation induced mutagenesis in Allium test.
authors.affiliation: National Pirogov Memorial Medical University, 56 Pyrohova str., Vinnytsya, 21018, Ukraine.
authors.forename: V M
authors.initials: VM
authors.lastname: Shkarupa
authors.affiliation: State Institution National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, Melnykov str., 53, Kyiv, 04050, Ukraine.
authors.forename: S V
authors.initials: SV
authors.lastname: Klymenko
authors.affiliation: State Institution National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, Melnykov str., 53, Kyiv, 04050, Ukraine.
authors.forename: V V
authors.initials: VV
authors.lastname: Talko
mesh_terms: D000490:Allium; D002588:Cesium Radioisotopes; D002869:Chromosome Aberrations; D002875:Chromosomes; D012964:Sodium
chemical_list: D002588:Cesium Radioisotopes; C000614989:Cesium-137; D012964:Sodium
keywords: Allium-test; G-irradiation; antimutagenesis; sodium humate