title: Pla a 2 and Pla a 3 reactivities identify plane tree-allergic patients with respiratory symptoms or food allergy.
abstract: Nine hundred and thirty-nine rPla a 1, nPla a 2, and rPla a 3 ImmunoCAP ISAC reactors were studied. nPla a 2posMUXF3posbut Pla a 1/2negsubjects were excluded from the study because they were cross-reactive carbohydrate determinant reactors. Among the 764 remaining participants, 71.9% were Pla a 3pos, 54.1% Pla a 2pos, and 10.9% Pla a 1pos. Among Pla a 3 reactors, 89.6% were Pru p 3posand 86.8% Jug 3pos, but the strongest IgE recognition relationship was observed between Pla a 3 and Jug r 3. Distinctive clinical subsets could be documented among plane tree-allergic patients. Pla a 3 reactors had both local and systemic food-induced reactions, but lower past respiratory symptoms occurrence. Pla a 2 reactivity was associated with respiratory symptoms but inversely related to systemic reactions to food. Cosensitization to Pla a 2 and Pla a 3 was associated with a lower past incidence of severe food-induced reactions.
authors.affiliation: Allergy Unit, IDI-IRCCS, Rome, Italy.
authors.forename: E
authors.identifier: http://orcid.org/0000-0002-9391-9168
authors.initials: E
authors.lastname: Scala
authors.affiliation: UOSD Allergy and Immunology, Azienda Sanitaria di Prato, Prato, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Cecchi
authors.affiliation: Health Services Research Unit, IDI-IRCCS, Rome, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Abeni
authors.affiliation: Allergy Unit, IDI-IRCCS, Rome, Italy.
authors.forename: E C
authors.initials: EC
authors.lastname: Guerra
authors.affiliation: Allergy Unit, IDI-IRCCS, Rome, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Pirrotta
authors.affiliation: Allergy Unit, IDI-IRCCS, Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Locanto
authors.affiliation: Allergy Unit, IDI-IRCCS, Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Giani
authors.affiliation: Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano, Milan, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Asero
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000485:Allergens / Q000276:immunology*; D052179:Antigens, Plant / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D005512:Food Hypersensitivity / Q000175:diagnosis*; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis* / Q000276:immunology*; D007073:Immunoglobulin E / Q000276:immunology; D007223:Infant; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D063189:Symptom Assessment; D064028:Tracheophyta / Q000009:adverse effects*; D014197:Trees; D055815:Young Adult
chemical_list: D000485:Allergens; D052179:Antigens, Plant; C521169:Pla a 2, Platanus acerifolia; D007073:Immunoglobulin E
keywords: Jug r 3; Pla a 2; Pla a 3; nonspecific lipid transfer protein; plane tree