title: Multifunctional nanoplatform for enhanced photodynamic cancer therapy and magnetic resonance imaging.
abstract: Co-delivery of photosensitizers and synergistic agents by one single nanoplatform is interesting for enhancing photodynamic therapy (PDT) of cancer. Here, a multifunctional nanoplatform for enhanced photodynamic therapy and magnetic resonance imaging of cancer was constructed. The poly (lactide-co-glycolide) (PLGA) nanoparticles (NPs) loaded with hematoporphyrin monomethyl ether (HMME) were coated with multifunctional manganese dioxide (MnO2) shells, which were designed as PLGA/HMME@MnO2NPs. Once the NPs were effectively taken up by tumor cells, the intracellular H2O2was catalysed by the MnO2shells to generate O2. Meanwhile, the higher glutathione (GSH) promoted the degradation of MnO2into Mn2+ions with the ability of magnetic resonance (MR) imaging. After the degradation of outer layer, the release of photosensitizer was promoted. Under irradiation, the released HMME produced cytotoxic reactive oxygen species (ROS) to damage the tumor cells when the O2was generated in the hypoxic tumor site. Furthermore, the decreased GSH level further inhibited the consumption of the produced ROS, which greatly enhanced the PDT efficacy. Therefore, this study suggested that this multifunctional system has the potential for enhanced photodynamic therapy and magnetic resonance imaging.
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, PR China; Collaborative Innovation Centre of New Drug Research and Safety Evaluation, Henan Province, 100 Kexue Avenue, Zhengzhou 450001, PR China.
authors.forename: Yongwei
authors.initials: Y
authors.lastname: Hao
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, PR China.
authors.forename: Bingxiang
authors.initials: B
authors.lastname: Zhang
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, PR China.
authors.forename: Cuixia
authors.initials: C
authors.lastname: Zheng
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, PR China.
authors.forename: Mengya
authors.initials: M
authors.lastname: Niu
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, PR China.
authors.forename: Haochen
authors.initials: H
authors.lastname: Guo
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, PR China.
authors.forename: Hongling
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Collaborative Innovation Centre of New Drug Research and Safety Evaluation, Henan Province, 100 Kexue Avenue, Zhengzhou 450001, PR China; School of Chemistry and Molecular Engineering, 100 Kexue Avenue, Zhengzhou 450001, PR China.
authors.forename: Junbiao
authors.initials: J
authors.lastname: Chang
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, PR China; Collaborative Innovation Centre of New Drug Research and Safety Evaluation, Henan Province, 100 Kexue Avenue, Zhengzhou 450001, PR China.
authors.forename: Zhenzhong
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, PR China; Collaborative Innovation Centre of New Drug Research and Safety Evaluation, Henan Province, 100 Kexue Avenue, Zhengzhou 450001, PR China; School of Chemistry and Molecular Engineering, 100 Kexue Avenue, Zhengzhou 450001, PR China. Electronic address: hahalei@139.com.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, PR China; Collaborative Innovation Centre of New Drug Research and Safety Evaluation, Henan Province, 100 Kexue Avenue, Zhengzhou 450001, PR China. Electronic address: zhangyundr@126.com.
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000818:Animals; D017209:Apoptosis; D003287:Contrast Media; D016503:Drug Delivery Systems; D005978:Glutathione / Q000737:chemistry; D006415:Hematoporphyrins / Q000737:chemistry; D006801:Humans; D006861:Hydrogen Peroxide / Q000737:chemistry; D007477:Ions / Q000737:chemistry; D019344:Lactic Acid / Q000737:chemistry*; D061986:MCF-7 Cells; D008279:Magnetic Resonance Imaging; D017895:Manganese Compounds / Q000737:chemistry*; D051379:Mice; D008856:Microscopy, Fluorescence; D053758:Nanoparticles / Q000737:chemistry*; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000188:drug therapy*; D010087:Oxides / Q000737:chemistry*; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000737:chemistry*; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D017382:Reactive Oxygen Species / Q000737:chemistry
chemical_list: D003287:Contrast Media; D006415:Hematoporphyrins; D007477:Ions; D017895:Manganese Compounds; D010087:Oxides; D017319:Photosensitizing Agents; D017382:Reactive Oxygen Species; C494379:hematoporphyrin monomethyl ether; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; C027424:manganese oxide; D006861:Hydrogen Peroxide; D005978:Glutathione; C016552:manganese dioxide
keywords: Magnetic resonance imaging; Manganese dioxide; Photodynamic therapy