title: Lupus anticoagulant - hypoprothrombinemia syndrome: a rare cause of intracranial bleeding.
abstract: : We report a 14-year-old girl who presented with subdural hematoma and a deranged coagulation profile suggestive of an inhibitor. Investigations revealed prothrombin deficiency along with positivity for antiphospholipid antibodies, which improved with steroid therapy. Bleeding diathesis in children and adolescents commonly results from thrombocytopenia, platelet function disorders, or coagulation factor deficiency; whereas bleeding because of coagulation factor inhibitors are extremely rare in this age group. This case also highlights the uncommon presentation of antiphospholipid antibody syndrome, as they often present with thrombosis or pregnancy complications rather than bleeding.
authors.affiliation: aDepartment of Hematology bDepartment of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: Sreejesh
authors.initials: S
authors.lastname: Sreedharanunni
authors.forename: Jasmina
authors.initials: J
authors.lastname: Ahluwalia
authors.forename: Narender
authors.initials: N
authors.lastname: Kumar
authors.forename: Sunil K
authors.initials: SK
authors.lastname: Bose
authors.forename: Rishi
authors.initials: R
authors.lastname: Dhawan
authors.forename: Pankaj
authors.initials: P
authors.lastname: Malhotra
mesh_terms: D000293:Adolescent; D016736:Antiphospholipid Syndrome / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D005260:Female; D006408:Hematoma, Subdural / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D007020:Hypoprothrombinemias / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D016682:Lupus Coagulation Inhibitor / Q000097:blood*; D013256:Steroids / Q000627:therapeutic use
chemical_list: D016682:Lupus Coagulation Inhibitor; D013256:Steroids