title: Long Noncoding RNA Identification: Comparing Machine Learning Based Tools for Long Noncoding Transcripts Discrimination.
abstract: Long noncoding RNA (lncRNA) is a kind of noncoding RNA with length more than 200 nucleotides, which aroused interest of people in recent years. Lots of studies have confirmed that human genome contains many thousands of lncRNAs which exert great influence over some critical regulators of cellular process. With the advent of high-throughput sequencing technologies, a great quantity of sequences is waiting for exploitation. Thus, many programs are developed to distinguish differences between coding and long noncoding transcripts. Different programs are generally designed to be utilised under different circumstances and it is sensible and practical to select an appropriate method according to a certain situation. In this review, several popular methods and their advantages, disadvantages, and application scopes are summarised to assist people in employing a suitable method and obtaining a more reliable result.
authors.affiliation: College of Computer Science and Technology, Key Laboratory of Symbol Computation and Knowledge Engineering of Ministry of Education, Jilin University, Changchun 130012, China.
authors.forename: Siyu
authors.identifier: 0000-0001-8709-5564
authors.initials: S
authors.lastname: Han
authors.affiliation: College of Computer Science and Technology, Key Laboratory of Symbol Computation and Knowledge Engineering of Ministry of Education, Jilin University, Changchun 130012, China; Zhuhai Laboratory of Key Laboratory of Symbol Computation and Knowledge Engineering of Ministry of Education, Zhuhai College of Jilin University, Zhuhai 519041, China.
authors.forename: Yanchun
authors.initials: Y
authors.lastname: Liang
authors.affiliation: College of Computer Science and Technology, Key Laboratory of Symbol Computation and Knowledge Engineering of Ministry of Education, Jilin University, Changchun 130012, China.
authors.forename: Ying
authors.identifier: 0000-0002-7804-149X
authors.initials: Y
authors.lastname: Li
authors.affiliation: College of Computer Science and Technology, Key Laboratory of Symbol Computation and Knowledge Engineering of Ministry of Education, Jilin University, Changchun 130012, China.
authors.forename: Wei
authors.identifier: 0000-0001-9872-4821
authors.initials: W
authors.lastname: Du
mesh_terms: D015894:Genome, Human; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D000069550:Machine Learning; D062085:RNA, Long Noncoding / Q000235:genetics* / Q000302:isolation & purification; D012984:Software
chemical_list: D062085:RNA, Long Noncoding