title: miR-590 accelerates lung adenocarcinoma migration and invasion through directly suppressing functional target OLFM4.
abstract: MicroRNA-590 (miR-590) shows oncogenic functions in various tumor types, but little is known about biological functions of miR-590 in lung adenocarcinoma. In this study, we observe that miR-590 is not only overexpressed in lung adenocarcinoma tissues and metastatic lymph nodes, but also significantly increased in lung adenocarcinoma cell lines. Moreover, gain-of-function and loss-of-function studies show miR-590 serve as a tumor suppressor regulating lung adenocarcinoma cells migration and invasion. Furthermore, OLFM4 is proved to as a functional target for miR-590 to regulate lung adenocarcinoma cells migration and invasion. In conclusion, miR-590 regulates lung adenocarcinoma metastasis through directly modulating functional target OLFM4.
authors.affiliation: Department of Respiratory Medicine, The First People's Hospital of Shangqiu, Shangqiu 476100, Henan, China.
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Respiratory Medicine, The First People's Hospital of Shangqiu, Shangqiu 476100, Henan, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Thoracic Surgery, Ji'nan Central Hospital Affiliated to Shandong University, No. 105 Jiefang Road, Ji'nan 250013, Shandong, China. Electronic address: xupeng163@hainan.com.
authors.forename: Peng
authors.initials: P
authors.lastname: Xu
mesh_terms: D000072283:A549 Cells; D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology; D000077192:Adenocarcinoma of Lung; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics*; D049109:Cell Proliferation / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D016147:Genes, Tumor Suppressor / Q000502:physiology; D016179:Granulocyte Colony-Stimulating Factor / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D008207:Lymphatic Metastasis / Q000235:genetics / Q000473:pathology; D035683:MicroRNAs / Q000235:genetics*; D009361:Neoplasm Invasiveness / Q000235:genetics* / Q000473:pathology
chemical_list: D035683:MicroRNAs; C454127:OLFM4 protein, human; D016179:Granulocyte Colony-Stimulating Factor
keywords: Lung adenocarcinoma; Metastasis; OLFM4; miR-590; microRNA