title: Perceptions of fecal microbiota transplantation forClostridium difficileinfection: factors that predict acceptance.
abstract: BACKGROUND
  Despite the effectiveness of fecal microbiota transplantation (FMT) for treating recurrentClostridium difficile(C. difficile) infection, some patients are reluctant to accept this therapy. Our study examined attitudes towards FMT and factors that contribute to patients' acceptance of this treatment.
  
  
  METHODS
  We distributed patient surveys at a Veterans Affairs hospital, a public hospital, and an academic faculty practice. Multivariable logistic regression was performed, adjusting for factors associated with FMT acceptance on univariate analysis and prior experience withC. difficileinfection.
  
  
  RESULTS
  Of 267 patients, only 12% knew of FMT prior to the survey, but 77% would undergo the procedure if medically indicated. On multivariable analysis, those with children and with college degrees or higher were more likely to agree to FMT (odds ratio [OR] 2.11, 95% confidence interval [CI] 1.02-4.35; OR 2.27, 95% CI 1.11-4.60 respectively). Sixty-five respondents (71%) chose colonoscopy as the preferred vehicle for FMT, while nasogastric tube was least preferred. Disease transmission was the most common concern (30%, n=242), and FMT success rate was the least selected concern (9.1%).
  
  
  CONCLUSIONS
  Most patients in a diverse sample of gastroenterology clinics had no prior knowledge of FMT, but were receptive to the procedure. Having children and higher education levels were predictors for FMT acceptance. Our findings suggest that barriers to FMT utilization may be overcome with counseling about safety concerns. More data on the risk of transmitting diseases or clinical characteristics, such as obesity, through FMT are needed and will be important for the acceptance of this procedure.
authors.affiliation: Division of Gastroenterology, NYU Langone Medical Center, New York City, NY (Leslie Park, Anjali Mone, Demetrios Tzimas, Jacqueline Hirsh, Michael A. Poles, Lisa Malter, Lea Ann Chen).
authors.forename: Leslie
authors.initials: L
authors.lastname: Park
authors.affiliation: Division of Gastroenterology, NYU Langone Medical Center, New York City, NY (Leslie Park, Anjali Mone, Demetrios Tzimas, Jacqueline Hirsh, Michael A. Poles, Lisa Malter, Lea Ann Chen).
authors.forename: Anjali
authors.initials: A
authors.lastname: Mone
authors.affiliation: Division of Gastroenterology, University of California San Francisco, San Francisco, California (Jennifer C. Price), USA.
authors.forename: Jennifer C
authors.initials: JC
authors.lastname: Price
authors.affiliation: Division of Gastroenterology, NYU Langone Medical Center, New York City, NY (Leslie Park, Anjali Mone, Demetrios Tzimas, Jacqueline Hirsh, Michael A. Poles, Lisa Malter, Lea Ann Chen).
authors.forename: Demetrios
authors.initials: D
authors.lastname: Tzimas
authors.affiliation: Division of Gastroenterology, NYU Langone Medical Center, New York City, NY (Leslie Park, Anjali Mone, Demetrios Tzimas, Jacqueline Hirsh, Michael A. Poles, Lisa Malter, Lea Ann Chen).
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Hirsh
authors.affiliation: Division of Gastroenterology, NYU Langone Medical Center, New York City, NY (Leslie Park, Anjali Mone, Demetrios Tzimas, Jacqueline Hirsh, Michael A. Poles, Lisa Malter, Lea Ann Chen).
authors.forename: Michael A
authors.initials: MA
authors.lastname: Poles
authors.affiliation: Division of Gastroenterology, NYU Langone Medical Center, New York City, NY (Leslie Park, Anjali Mone, Demetrios Tzimas, Jacqueline Hirsh, Michael A. Poles, Lisa Malter, Lea Ann Chen).
authors.forename: Lisa
authors.initials: L
authors.lastname: Malter
authors.affiliation: Division of Gastroenterology, NYU Langone Medical Center, New York City, NY (Leslie Park, Anjali Mone, Demetrios Tzimas, Jacqueline Hirsh, Michael A. Poles, Lisa Malter, Lea Ann Chen).
authors.forename: Lea Ann
authors.initials: LA
authors.lastname: Chen
keywords: Clostridium difficile; FMT; Fecal microbiota transplantation; fecal transplant; patient perceptions