title: Different Golgi ultrastructure across species and tissues: Implications under functional and pathological conditions, and an attempt at classification.
abstract: The Golgi complex (GC) is the central station of the secretory pathway, through which several paths of intracellular transport are connected. The main function of the GC is glycosylation of proteins and lipids, and their subsequent sorting. The structure of the GC is extremely complicated, although in general it is unbelievably similar across different cells types and under different functional and pathological conditions. However, there are also a lot of differences between the GCs in different cells and under different normal and pathological conditions. Here, we compare the phenotypes of the GCs in different organisms under these different conditions, in particular according to morphological criteria. We propose a classification of the GC types that reflects the different features of the GC, and that depends on the different molecular machines.
authors.affiliation: The FIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy. Electronic address: alexandre.mironov@ifom.eu.
authors.forename: Alexander A
authors.initials: AA
authors.lastname: Mironov
authors.affiliation: Department of Anatomy, Ivanovo State Medical Academy, 153462 Ivanovo, Russia.
authors.forename: Irina S
authors.initials: IS
authors.lastname: Sesorova
authors.affiliation: Laboratory of Renal Physiology, Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, Torez Avenue, 44, 194223 St. Petersburg, Russia.
authors.forename: Elena V
authors.initials: EV
authors.lastname: Seliverstova
authors.affiliation: The FIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy.
authors.forename: Galina V
authors.initials: GV
authors.lastname: Beznoussenko
mesh_terms: D000818:Animals; D019143:Evolution, Molecular; D006056:Golgi Apparatus / Q000145:classification / Q000235:genetics* / Q000473:pathology / Q000648:ultrastructure*; D006801:Humans; D009928:Organ Specificity; D013045:Species Specificity
keywords: COPI; COPII; Clathrin; Golgi classification; Golgi complex; Golgi structure; Intracellular transport; TGN