title: The function of NOD-like receptors in central nervous system diseases.
abstract: NOD-like receptors (NLRs) are critical cytoplasmic pattern-recognition receptors (PRRs) that play an important role in the host innate immune response and immunity homeostasis. There is a growing body of evidence that NLRs are involved in a wide range of inflammatory diseases, including cancer, metabolic diseases, and autoimmune disorders. Recent studies have indicated that the proteins of the NLR family are linked with the pathophysiology of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS), and psychological diseases. In this review, we mainly focus on the role of NLRs and the underlying signaling pathways in central nervous system (CNS) diseases. © 2016 Wiley Periodicals, Inc.
authors.affiliation: The State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.|School of Basic Medical Science, Lanzhou University, Lanzhou, 730000, Gansu Province, China.
authors.forename: Xiangxi
authors.initials: X
authors.lastname: Kong
authors.affiliation: The State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.|Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Beijing, 100069, China.
authors.forename: Zengqiang
authors.initials: Z
authors.lastname: Yuan
authors.affiliation: The State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.|Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Beijing, 100069, China.
authors.forename: Jinbo
authors.initials: J
authors.lastname: Cheng
mesh_terms: D000818:Animals; D002493:Central Nervous System Diseases / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D000070576:NLR Proteins / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D000070576:NLR Proteins
keywords: NOD-like receptors; inflammasome; innate immunity; neurodegeneration; neuroinflammation