title: Numerical Study of Blood Clots Influence on the Flow Pattern and Platelet Activation on a Stented Bifurcation Model.
abstract: Stent implantation is a common procedure followed in arteries affected by atherosclerosis. This procedure can lead to other stenting-related problems. One of these is the deposition and accumulation of blood clots over stent struts. This process can have further consequences, in so far as it can introduce modifications to the flow pattern. This problem is especially critical in stented bifurcations, where resulting stent geometry is more complex. In this regard, a numerical study is presented of the effect on the flow pattern and platelet activation of blood clot depositions on the stent struts of a stented coronary bifurcation. The numerical model is first validated with experimental measurements performed for this purpose. Experiments considered a flow with suspended artificial thrombi, which naturally deposited on stent struts. The location and shape observed were used to create numerical thrombi. Following this, numerical simulations were performed to analyze the influence of the presence of thrombi depositions on parameters such as Time Averaged Wall Shear Stress, Oscillatory Shear Index or Relative Residence Time. Finally, a study was also carried out of the effect of different geometrical configurations, from a straight tube to a stented bifurcation model with thrombus depositions, on platelet activation.
authors.affiliation: Depto. Ingeniería Energética y Fluidomecánica, Escuela de Ingenierías Industriales, Universidad de Valladolid, Paseo del Cauce 59, 47011, Valladolid, Spain. pedro.garcia@eii.uva.es.
authors.forename: P
authors.identifier: 0000-0003-0693-4034
authors.initials: P
authors.lastname: García Carrascal
authors.affiliation: Depto. Ingeniería Energética, Escuela Técnica Superior de Industriales, Universidad Politécnica de Madrid, C/José Gutiérrez Abascal, 28006, Madrid, Spain.
authors.forename: J
authors.initials: J
authors.lastname: García García
authors.affiliation: Depto. Ingeniería Energética y Fluidomecánica, Escuela de Ingenierías Industriales, Universidad de Valladolid, Paseo del Cauce 59, 47011, Valladolid, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Sierra Pallares
authors.affiliation: Depto. Ingeniería Energética y Fluidomecánica, Escuela de Ingenierías Industriales, Universidad de Valladolid, Paseo del Cauce 59, 47011, Valladolid, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Castro Ruiz
authors.affiliation: Depto. Ingeniería Energética, Escuela Técnica Superior de Industriales, Universidad Politécnica de Madrid, C/José Gutiérrez Abascal, 28006, Madrid, Spain.
authors.forename: F J
authors.initials: FJ
authors.lastname: Manuel Martín
mesh_terms: D001777:Blood Coagulation; D001783:Blood Flow Velocity; D001792:Blood Platelets / Q000378:metabolism*; D003326:Coronary Circulation; D006801:Humans; D008955:Models, Cardiovascular; D015539:Platelet Activation; D015607:Stents; D013927:Thrombosis / Q000378:metabolism / Q000503:physiopathology
keywords: Coronary bifurcation; Hemodynamics; Platelet; Stent; Thrombus