title: Necrotizing fasciitis in a patient receiving tocilizumab for rheumatoid arthritis - Case report.
abstract: We present a case of necrotizing fasciitis in a 66-year-old Caucasian woman with rheumatoid arthritis receiving tocilizumab, and provide a review of published cases. The patient exhibited no systemic symptoms and discreet cutaneous inflammatory signals at presentation. She was successfully treated with broad-spectrum empiric antibiotic therapy and surgical debridement.
authors.affiliation: Rheumatology Department, Centro Hospitalar São João, Portugal. Electronic address: di9_goncalves@hotmail.com.
authors.forename: Diana
authors.initials: D
authors.lastname: Rosa-Gonçalves
authors.affiliation: Rheumatology Department, Centro Hospitalar São João, Portugal.
authors.forename: Miguel
authors.initials: M
authors.lastname: Bernardes
authors.affiliation: Rheumatology Department, Centro Hospitalar São João, Portugal.
authors.forename: Lúcia
authors.initials: L
authors.lastname: Costa
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage / Q000009:adverse effects*; D018501:Antirheumatic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D003131:Combined Modality Therapy; D003646:Debridement; D019115:Fasciitis, Necrotizing / Q000139:chemically induced* / Q000188:drug therapy / Q000601:surgery; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D061067:Antibodies, Monoclonal, Humanized; D018501:Antirheumatic Agents; D007166:Immunosuppressive Agents; C502936:tocilizumab
keywords: Antagonistas del factor de necrosis tumoral alfa; Artritis reumatoide; Fascitis necrosante; Infección; Infection; Necrotizing fasciitis; Piel; Rheumatoid arthritis; Skin; Tocilizumab; Tumor necrosis factor antagonists