title: Cardiometabolic Risks in Polycystic Ovary Syndrome: Non-Traditional Risk Factors and the Impact of Obesity.
abstract: Polycystic ovary syndrome (PCOS) is a common and complex endocrinopathy with reproductive, metabolic, and psychological features and significantly increased cardiometabolic risks. PCOS is underpinned by inherent insulin resistance and hyperandrogenism. Obesity, more common in PCOS, plays an important role in the pathophysiology, exacerbating hyperinsulinaemia and hyperandrogenism, leading to recommended first-line lifestyle intervention. Significant traditional and non-traditional risk factors are implicated in PCOS in addition to obesity-exacerbated cardiometabolic risks and are explored in this review to promote the understanding of this common metabolic and reproductive condition.
authors.affiliation: Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Clayton, VIC, Australia.
authors.forename: Wei-Ling
authors.initials: WL
authors.lastname: Chiu
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Boyle
authors.forename: Amanda
authors.initials: A
authors.lastname: Vincent
authors.forename: Helena
authors.initials: H
authors.lastname: Teede
authors.forename: Lisa J
authors.initials: LJ
authors.lastname: Moran
mesh_terms: D005260:Female; D006801:Humans; D017588:Hyperandrogenism; D007333:Insulin Resistance; D009206:Myocardium / Q000378:metabolism*; D009765:Obesity / Q000150:complications / Q000378:metabolism*; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000378:metabolism*; D012307:Risk Factors