title: Cataract surgery in uveitis: a multicentre database study.
abstract: Cataract is an important source of visual loss in patients with uveitis. Whether or not outcomes of cataract surgery in eyes with uveitis are worse compared with non-uveitic eyes have to date been compromised by lack of reliable estimates of benefit and harm, which require data from large cohorts.
  
  
  
  Electronic medical record data were extracted from eight independent UK clinical sites for eyes undergoing cataract extraction between January 2010 and December 2014. 1173 eyes with a recorded diagnosis of uveitis were compared with a reference group of 95 573 eyes from the same dataset.
  
  
  
  Uveitic eyes represented 1.2% of all eyes undergoing cataract surgery. Eyes in the uveitic group had worse preoperative visual acuity (0.87 vs 0.65 logarithm of the minimum angle of resolution (logMAR) units), were from younger patients and had shorter axial lengths and a higher incidence of ocular copathology including glaucoma. A greater number had documented small pupils, required additional surgical procedures, developed more intraoperative complications and had poorer postoperative visual acuity at all time points measured up to 6 months (0.41 vs 0.27 logMAR units at 12-24 weeks).
  
  
  
  This large study cohort of eyes with a diagnosis of uveitis undergoing cataract surgery highlights more precisely the complex surgical demands, copathology and worse visual outcomes in this group. These data will allow more accurate preoperative counselling and planning. Although improvement in visual acuity is achieved in most cases, prognosis should be guarded, so that patient expectations are met. Compared with the non-uveitic population, the mean postoperative visual acuity is between one and two lines worse at all time points.
authors.affiliation: Academic Unit of Ophthalmology, School of Clinical Sciences and School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK.|Bristol Eye Hospital, Bristol, UK.
authors.forename: Colin J
authors.initials: CJ
authors.lastname: Chu
authors.affiliation: Academic Unit of Ophthalmology, School of Clinical Sciences and School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK.|Bristol Eye Hospital, Bristol, UK.|Institute of Ophthalmology, UCL, London, UK.|National Institute for Health Research (NIHR) Biomedical Research Centre at Moorfields Eye Hospital and University College London Institute of Ophthalmology, London, UK.
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Dick
authors.affiliation: Gloucestershire Eye Unit, Cheltenham General Hospital, Cheltenham, UK.
authors.forename: Robert L
authors.initials: RL
authors.lastname: Johnston
authors.affiliation: Wolverhampton Eye Infirmary, Royal Wolverhampton Hospitals NHS Trust, Wolverhampton, UK.
authors.forename: Yit C
authors.initials: YC
authors.lastname: Yang
authors.affiliation: Ophthalmology Department, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.|Academic Unit of Ophthalmology, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.
authors.forename: Alastair K
authors.identifier: 0000-0001-7849-0087
authors.initials: AK
authors.lastname: Denniston
mesh_terms: D000368:Aged; D002386:Cataract / Q000150:complications* / Q000503:physiopathology; D002387:Cataract Extraction / Q000379:methods*; D005260:Female; D006801:Humans; D007431:Intraoperative Complications / Q000209:etiology / Q000503:physiopathology; D008297:Male; D011183:Postoperative Complications / Q000209:etiology / Q000503:physiopathology; D016896:Treatment Outcome; D014605:Uveitis / Q000150:complications* / Q000503:physiopathology; D014786:Vision Disorders / Q000503:physiopathology / Q000601:surgery; D014792:Visual Acuity / Q000502:physiology
keywords: Inflammation; Lens and zonules; Treatment Surgery