title: High Serum Adipocyte Fatty Acid Binding Protein Is Associated with Metabolic Syndrome in Patients with Type 2 Diabetes.
abstract: Adipocyte fatty acid binding protein (A-FABP) is a key mediator of obesity-related metabolic syndrome (MetS). The aim of this study was to evaluate the relationship between A-FABP concentration and MetS in type 2 diabetes mellitus (DM) patients. Fasting blood samples were obtained from 165 type 2 DM volunteers. MetS and its components were defined using diagnostic criteria from the International Diabetes Federation. Among 165 DM patients, 113 patients (68.5%) had MetS. Diabetic persons who had MetS had significantly higher A-FABP levels (P< 0.001) than those without MetS. Female DM persons had higher A-FABP level than man (P< 0.001). No statistically significant differences in A-FABP levels were found in use of statin, fibrate, or antidiabetic drugs. Multivariate forward stepwise linear regression analysis revealed that body fat mass (P< 0.001), logarithmically transformed creatinine (log-creatinine;P< 0.001), female DM patients (P< 0.001), and logarithmically transformed high sensitive C-reactive protein (log-hs-CRP;P= 0.013) were positively correlated, while albumin (P= 0.004) and glomerular filtration rate (GFR;P= 0.043) were negatively correlated with serum A-FABP levels in type 2 DM patients. In this study, higher serum A-FABP level was positively associated with MetS in type 2 DM patients.
authors.affiliation: Division of Metabolism and Endocrinology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.
authors.forename: Jer-Chuan
authors.initials: JC
authors.lastname: Li
authors.affiliation: Division of Metabolism and Endocrinology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan; School of Medicine, Tzu Chi University, Hualien, Taiwan.
authors.forename: Du-An
authors.initials: DA
authors.lastname: Wu
authors.affiliation: Division of Nephrology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan; Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan.
authors.forename: Jia-Sian
authors.initials: JS
authors.lastname: Hou
authors.affiliation: Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan; Department of Nursing, Tzu Chi University, Hualien, Taiwan.
authors.forename: Yi-Maun
authors.initials: YM
authors.lastname: Subeq
authors.affiliation: Division of Metabolism and Endocrinology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.
authors.forename: Hsin-Dean
authors.initials: HD
authors.lastname: Chen
authors.affiliation: School of Medicine, Tzu Chi University, Hualien, Taiwan; Division of Nephrology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan; Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan.
authors.forename: Bang-Gee
authors.identifier: 0000-0001-9364-4558
authors.initials: BG
authors.lastname: Hsu
mesh_terms: D000368:Aged; D000418:Albumins / Q000378:metabolism; D000886:Anthropometry; D002097:C-Reactive Protein / Q000378:metabolism; D003404:Creatinine / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D050556:Fatty Acid-Binding Proteins / Q000378:metabolism*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000150:complications; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity / Q000097:blood* / Q000150:complications; D012737:Sex Factors
chemical_list: D000418:Albumins; C493410:FABP4 protein, human; D050556:Fatty Acid-Binding Proteins; D002097:C-Reactive Protein; D003404:Creatinine