title: The role of microRNAs in the pathophysiology of adrenal tumors.
abstract: MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression in a sequence-specific manner. Due to its association with an assortment of diseases, miRNAs have been extensively studied in the last decade. In this review, the current understanding of the role of miRNAs in the pathophysiology of adrenal tumors is discussed. The recent contributions of high-throughput miRNA profiling studies have identified miRNAs that have functional and molecular roles in adrenal tumorigenesis. With respect to the biological heterogeneity of adrenal tumors and the limitations of the current treatments, an improved understanding of miRNAs may hold potential diagnostic and therapeutic value to facilitate better clinical management.
authors.affiliation: Cancer Genetics Laboratory, Kolling Institute, Northern Sydney Local Health District, St Leonards, NSW, Australia; Sydney Medical School Northern, Royal North Shore Hospital, University of Sydney, Australia.
authors.forename: Nunki
authors.initials: N
authors.lastname: Hassan
authors.affiliation: Cancer Genetics Laboratory, Kolling Institute, Northern Sydney Local Health District, St Leonards, NSW, Australia; Sydney Medical School Northern, Royal North Shore Hospital, University of Sydney, Australia.
authors.forename: Jing Ting
authors.initials: JT
authors.lastname: Zhao
authors.affiliation: Cancer Genetics Laboratory, Kolling Institute, Northern Sydney Local Health District, St Leonards, NSW, Australia; Sydney Medical School Northern, Royal North Shore Hospital, University of Sydney, Australia; University of Sydney Endocrine Surgery Unit, Royal North Shore Hospital, Sydney, St Leonards, Sydney, NSW, Australia. Electronic address: stansidhu@nebsc.com.au.
authors.forename: Stan B
authors.initials: SB
authors.lastname: Sidhu
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy; D000311:Adrenal Glands / Q000378:metabolism / Q000503:physiopathology; D000312:Adrenal Hyperplasia, Congenital / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy; D018268:Adrenocortical Carcinoma / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy; D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D016503:Drug Delivery Systems / Q000379:methods; D055098:Endocrine Cells / Q000378:metabolism / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism / Q000627:therapeutic use; D010673:Pheochromocytoma / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy; D015398:Signal Transduction
chemical_list: D035683:MicroRNAs
keywords: Adrenal tumors; Adrenocortical carcinoma; MicroRNA; Pheochromocytomas