title: [The research of proteome profiling change of 1-bromopropane poisoning cases].
abstract: Objective:This study was mainly focused on styudy on he proteome profile change between exposure to 1-Bromopropane (1-BP) and 1-BP poisoning.Methods:The samples of serums from exposure to 1-BP and 1-BP poisoning were collected and analyzed through Label free proteome technology platform. The differently expressed proteins between the two groups were quantified and identified, followed by function analysis by bioinformatics.Results:127 proteins over 2 fold-change were selected, in which 39 proteins were up-regulated and 88 proteins were down-regulated. These different-ly expressed proteins were mainly involved in the process of enzyme active regulation, inflammatory reaction, protein modification, stress response, coagulation, transport.Conclusion:The differently expressed proteins provided the potential protein biomarkers for the early diagnosis of 1-BP poisoning and was beneficial for clinical diagnosis of 1-BP and understanding of the mechanism of 1-BP poisoning.
authors.affiliation: Wuxi 8th People's Hospital (Wuxi Hospital for Prevention and Treatment of Occupational Disease) , Wuxi 2140028, China.
authors.forename: R M
authors.initials: RM
authors.lastname: Miao
authors.forename: B M
authors.initials: BM
authors.lastname: Ding
authors.forename: Y Y
authors.initials: YY
authors.lastname: Zhang
authors.forename: W M
authors.initials: WM
authors.lastname: Wu
authors.forename: D H
authors.initials: DH
authors.lastname: You
authors.forename: Z H
authors.initials: ZH
authors.lastname: Fang
authors.forename: R
authors.initials: R
authors.lastname: Zhao
mesh_terms: D015415:Biomarkers; D015536:Down-Regulation; D020869:Gene Expression Profiling; D006801:Humans; D006842:Hydrocarbons, Brominated / Q000506:poisoning; D020543:Proteome; D040901:Proteomics; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; D006842:Hydrocarbons, Brominated; D020543:Proteome; C118559:1-bromopropane