title: Association between 24-hour combined multichannel intraluminal impedance-pH monitoring and symptoms or quality of life in patients with laryngopharyngeal reflux.
abstract: OBJECTIVE
  To evaluate the association between the parameters of 24-hour multichannel intraluminal impedance (MII)-pH monitoring and the symptoms or quality of life (QoL) in laryngopharyngeal reflux (LPR) patients.
  
  
  METHODS
  Prospective cohort study without controls.
  
  
  METHODS
  University teaching hospital.
  
  
  METHODS
  Forty-five LPR patients were selected from subjects who underwent 24-hour MII-pH monitoring and were diagnosed with LPR from September 2014 to May 2015. Reflux Symptom Index (RSI), Health-related Quality of Life (HRQoL), Short Form 12 (SF-12) Survey questionnaires were surveyed. Spearman's correlation was used to analyse the association between the symptoms or QoL and 24-hour MII-pH monitoring.
  
  
  RESULTS
  Most parameters in 24-hour MII-pH monitoring showed weak or no correlation with RSI, HRQoL and SF-12. Only number of non-acid reflux events that reached the larynx and pharynx (LPR-non-acid) and number of total reflux events that reached the larynx and pharynx (LPR-total) parameters showed strong correlation with heartburn in RSI (R = 0.520, P < 0.001, R = 0.478, P = 0.001, respectively). Multiple regression analysis showed that there was only one significant regression coefficient between LPR-non-acid and voice/hoarseness portion of HRQoL (b = 1.719, P = 0.022).
  
  
  CONCLUSIONS
  Most parameters of 24-hour MII-pH monitoring did not reflect subjective symptoms or QoL in patients with LPR.
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, School of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: S I
authors.initials: SI
authors.lastname: Kim
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, School of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: O E
authors.initials: OE
authors.lastname: Kwon
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, School of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: S Y
authors.initials: SY
authors.lastname: Na
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, School of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: Y C
authors.initials: YC
authors.lastname: Lee
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, School of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: J M
authors.initials: JM
authors.lastname: Park
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, School of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: Y G
authors.initials: YG
authors.lastname: Eun
mesh_terms: D017097:Electric Impedance; D050782:Esophageal pH Monitoring / Q000379:methods*; D004947:Esophagus / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D057045:Laryngopharyngeal Reflux / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology; D007830:Larynx / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D011788:Quality of Life; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires