title: Synthesis of Fused Pyrimidinone and Quinolone Derivatives in an Automated High-Temperature and High-Pressure Flow Reactor.
abstract: Fused pyrimidinone and quinolone derivatives that are of potential interest to pharmaceutical research were synthesized within minutes in up to 96% yield in an automated Phoenix high-temperature and high-pressure continuous flow reactor. Heterocyclic scaffolds that are either hard to synthesize or require multisteps are readily accessible using a common set of reaction conditions. The use of low-boiling solvents along with the high conversions of these reactions allowed for facile workup and isolation. The methods reported herein are highly amenable for fast and efficient heterocycle synthesis as well as compound scale-ups.
authors.affiliation: Discovery Chemistry and Technologies, AbbVie, Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Tsoung
authors.affiliation: Discovery Chemistry and Technologies, AbbVie, Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Bogdan
authors.affiliation: Discovery Chemistry and Technologies, AbbVie, Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
authors.forename: Stanislaw
authors.initials: S
authors.lastname: Kantor
authors.affiliation: Discovery Chemistry and Technologies, AbbVie, Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
authors.forename: Ying
authors.identifier: 0000-0001-9516-3483
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Medicinal Chemistry, University of Kansas , Lawrence, Kansas 66047, United States.
authors.forename: Manwika
authors.initials: M
authors.lastname: Charaschanya
authors.affiliation: Discovery Chemistry and Technologies, AbbVie, Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
authors.forename: Stevan W
authors.initials: SW
authors.lastname: Djuric