title: Red Cell Immunohematology Research Conducted in China.
abstract: ABO subtypes and RhD variants are the most studied blood groups in China. Some of the polymorphisms in these two blood groups have direct clinical relevance. Molecular diagnosis of blood group polymorphisms is underway in China. In addition, research groups have developed methods such as screening for blood group mimetic peptides using phage display technology. New reagents, akin to antibodies directed against RhD and ABO, are being investigated using aptamer-based techniques. Progress is also being made in the development of synthetic exoglycosidases for conversion of group A and/or B antigens to group O. Development of methoxy-polyethylene-glycol modified red cells has been successful in vitro but has not reached clinical application. In this paper, we summarize red cell immunohematology research that has been conducted in China.
authors.affiliation: Shanghai Blood Center, Shanghai, China. Electronic address: zhuziyan@sbc.org.cn.
authors.forename: Ziyan
authors.initials: Z
authors.lastname: Zhu
authors.affiliation: Shanghai Blood Center, Shanghai, China.
authors.forename: Luyi
authors.initials: L
authors.lastname: Ye
authors.affiliation: Shanghai Blood Center, Shanghai, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Li
authors.affiliation: Beijing Institute of Transfusion Medicine, Beijing, China.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Gao
authors.affiliation: Beijing Institute of Transfusion Medicine, Beijing, China.
authors.forename: Yinxia
authors.initials: Y
authors.lastname: Tan
authors.affiliation: The Johns Hopkins Hospital, Baltimore, MD, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Cai
mesh_terms: D035843:Biomedical Research / Q000379:methods / Q000458:organization & administration; D001788:Blood Grouping and Crossmatching / Q000379:methods; D002681:China; D004912:Erythrocytes / Q000276:immunology*; D006801:Humans; D012204:Rh-Hr Blood-Group System / Q000276:immunology; D064826:Transfusion Medicine / Q000379:methods / Q000458:organization & administration; D014181:Transplantation Immunology
chemical_list: D012204:Rh-Hr Blood-Group System
keywords: ABO; Blood groups; Immunohematology