title: New bimetallic dicyanidoargentate(I)-based coordination compounds: Synthesis, characterization, biological activities and DNA-BSA binding affinities.
abstract: Four compounds -two (2 and 3) completely new- of composition [Ni(edbea)Ag3(CN)5] (1), [Cu(edbea)Ag2(CN)4]·H2O (2), [Cd(edbea)Ag3(CN)5]·H2O (3) and [Cd(edbea)2] [Ag(CN)2]2·H2O (4) {edbea; 2,2'-(ethylenedioxy)bis (ethylamine)}, were synthesized and characterized using elemental, FT-IR, X-Ray (4), thermal, variable temperature magnetic measurement (1 and 2) and biological techniques. The DNA/BSA binding affinities of 2 and 3 were evaluated by UV-Vis spectrophotometric titrations, ethidium bromide exchange experiments and electrophoretic mobility measurements. Compounds 1 and 4 have previously been characterized and shown to reduce the proliferation and migration of tumor cells. For the sake of clarity, 1 precise mechanism of action on microbial organisms and temperature magnetic measurement were determined. The crystallographic analyses showed that 4 was built up of [Cd(edbea)2]IIcations and [Ag2(CN)4]IIanions. Complexes demonstrated a remarkable antibacterial (1-4), antifungal (1-4) and antiproliferative activities (2 and 3) to ten human bacterial pathogens, four plant pathogenic fungi or three tumor cells (HeLa, HT29, and C6), respectively. Therefore, our results strongly confirm that cell proliferation, cell morphology, Bcl-2, P53 changes and apoptosis can be related to the pharmacological effects of the complexes as suitable candidate for clinical trials.
authors.affiliation: Department of Chemistry, College of Arts and Science, Gaziosmanpaşa University, 60250 Tokat, Turkey.
authors.forename: Nesrin
authors.initials: N
authors.lastname: Korkmaz
authors.affiliation: Department of Molecular Biology and Genetics, Gaziosmanpaşa University, 60250 Tokat, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Aydın
authors.affiliation: Department of Chemistry, College of Arts and Science, Gaziosmanpaşa University, 60250 Tokat, Turkey. Electronic address: ahmet.karadag@gop.edu.tr.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Karadağ
authors.affiliation: Department of Plant Protection, Faculty of Agriculture, Gaziosmanpaşa University, 60250 Tokat, Turkey.
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Yanar
authors.affiliation: Department of Biotechnology, Çukurova University, 01330 Adana, Turkey.
authors.forename: Yelis
authors.initials: Y
authors.lastname: Maaşoğlu
authors.affiliation: Department of Chemistry, Faculty of Science, Atatürk University, 25240 Erzurum, Turkey.
authors.forename: Ertan
authors.initials: E
authors.lastname: Şahin
authors.affiliation: Department of Molecular Biology and Genetics, Gaziosmanpaşa University, 60250 Tokat, Turkey.
authors.forename: Şaban
authors.initials: Ş
authors.lastname: Tekin
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects*; D002104:Cadmium / Q000737:chemistry / Q000494:pharmacology; D002417:Cattle; D049109:Cell Proliferation / Q000187:drug effects*; D056831:Coordination Complexes / Q000737:chemistry / Q000494:pharmacology; D004247:DNA / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D012834:Silver / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D056831:Coordination Complexes; D002104:Cadmium; D012710:Serum Albumin, Bovine; D012834:Silver; D004247:DNA
keywords: 2,2′-(ethylenedioxy)bis(ethylamine); Anticancer activity; Antifugal activity; Antimicrobial activity; Apoptosis; Dicyanidoargentat(I)