title: Impaired health-related quality of life in meningioma patients-a systematic review.
abstract: While surgical and radiotherapeutic improvements increased life expectancy of meningioma patients, little is known about these patients' health-related quality of life (HRQoL). Therefore, the objectives of this systematic review were to assess HRQoL in meningioma patients, the methodological quality of the used questionnaires (COSMIN criteria), and the reporting level of patient-reported outcomes (PROs) in the included studies (International Society of Quality of Life Research criteria).Nineteen articles met our inclusion criteria. HRQoL was measured with 13 different questionnaires, 3 validated in meningioma patients. According to our predefined cutoff, HRQoL data were reported sufficiently in 5 out of 19 studies. Both findings hamper interpretation of the PRO results.In general, meningioma patients reported clinically worse HRQoL than healthy controls. Although meningioma patients had better HRQoL than glioma patients, this difference was not clinically relevant. Radiotherapy seemed to improve some domains of HRQoL in the short term, while HRQoL decreased to pre-radiotherapy levels in the long term. Tumor resection increased HRQoL, but long-term follow-up showed persistent reduced HRQoL compared with healthy controls. These results suggest an impaired HRQoL in meningioma patients, even years after anti-tumor treatment. Results of this systematic review warrant high quality prospective studies, better instruments to assess HRQoL, and improved level of reporting for this group of patients.
authors.affiliation: Department of Neurosurgery, Leiden University Medical Center, Leiden, The Netherlands; Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands; Department of Neurosurgery, Utrecht Medical Center, Utrecht, The Netherlands; Department of Neurosurgery, VU Medical Center, Amsterdam, The Netherlands; Department of Neurosurgery, Medical Center Haaglanden, The Hague, The Netherlands; Department of Neurology, Medical Center Haaglanden, The Hague, The Netherlands.
authors.forename: Amir H
authors.initials: AH
authors.lastname: Zamanipoor Najafabadi
authors.affiliation: Department of Neurosurgery, Leiden University Medical Center, Leiden, The Netherlands; Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands; Department of Neurosurgery, Utrecht Medical Center, Utrecht, The Netherlands; Department of Neurosurgery, VU Medical Center, Amsterdam, The Netherlands; Department of Neurosurgery, Medical Center Haaglanden, The Hague, The Netherlands; Department of Neurology, Medical Center Haaglanden, The Hague, The Netherlands.
authors.forename: Marthe C M
authors.initials: MCM
authors.lastname: Peeters
authors.affiliation: Department of Neurosurgery, Leiden University Medical Center, Leiden, The Netherlands; Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands; Department of Neurosurgery, Utrecht Medical Center, Utrecht, The Netherlands; Department of Neurosurgery, VU Medical Center, Amsterdam, The Netherlands; Department of Neurosurgery, Medical Center Haaglanden, The Hague, The Netherlands; Department of Neurology, Medical Center Haaglanden, The Hague, The Netherlands.
authors.forename: Linda
authors.initials: L
authors.lastname: Dirven
authors.affiliation: Department of Neurosurgery, Leiden University Medical Center, Leiden, The Netherlands; Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands; Department of Neurosurgery, Utrecht Medical Center, Utrecht, The Netherlands; Department of Neurosurgery, VU Medical Center, Amsterdam, The Netherlands; Department of Neurosurgery, Medical Center Haaglanden, The Hague, The Netherlands; Department of Neurology, Medical Center Haaglanden, The Hague, The Netherlands.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Lobatto
authors.affiliation: Department of Neurosurgery, Leiden University Medical Center, Leiden, The Netherlands; Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands; Department of Neurosurgery, Utrecht Medical Center, Utrecht, The Netherlands; Department of Neurosurgery, VU Medical Center, Amsterdam, The Netherlands; Department of Neurosurgery, Medical Center Haaglanden, The Hague, The Netherlands; Department of Neurology, Medical Center Haaglanden, The Hague, The Netherlands.
authors.forename: Justus L
authors.initials: JL
authors.lastname: Groen
authors.affiliation: Department of Neurosurgery, Leiden University Medical Center, Leiden, The Netherlands; Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands; Department of Neurosurgery, Utrecht Medical Center, Utrecht, The Netherlands; Department of Neurosurgery, VU Medical Center, Amsterdam, The Netherlands; Department of Neurosurgery, Medical Center Haaglanden, The Hague, The Netherlands; Department of Neurology, Medical Center Haaglanden, The Hague, The Netherlands.
authors.forename: Marieke L D
authors.initials: MLD
authors.lastname: Broekman
authors.affiliation: Department of Neurosurgery, Leiden University Medical Center, Leiden, The Netherlands; Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands; Department of Neurosurgery, Utrecht Medical Center, Utrecht, The Netherlands; Department of Neurosurgery, VU Medical Center, Amsterdam, The Netherlands; Department of Neurosurgery, Medical Center Haaglanden, The Hague, The Netherlands; Department of Neurology, Medical Center Haaglanden, The Hague, The Netherlands.
authors.forename: Saskia M
authors.initials: SM
authors.lastname: Peerdeman
authors.affiliation: Department of Neurosurgery, Leiden University Medical Center, Leiden, The Netherlands; Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands; Department of Neurosurgery, Utrecht Medical Center, Utrecht, The Netherlands; Department of Neurosurgery, VU Medical Center, Amsterdam, The Netherlands; Department of Neurosurgery, Medical Center Haaglanden, The Hague, The Netherlands; Department of Neurology, Medical Center Haaglanden, The Hague, The Netherlands.
authors.forename: Wilo C
authors.initials: WC
authors.lastname: Peul
authors.affiliation: Department of Neurosurgery, Leiden University Medical Center, Leiden, The Netherlands; Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands; Department of Neurosurgery, Utrecht Medical Center, Utrecht, The Netherlands; Department of Neurosurgery, VU Medical Center, Amsterdam, The Netherlands; Department of Neurosurgery, Medical Center Haaglanden, The Hague, The Netherlands; Department of Neurology, Medical Center Haaglanden, The Hague, The Netherlands.
authors.forename: Martin J B
authors.initials: MJB
authors.lastname: Taphoorn
authors.affiliation: Department of Neurosurgery, Leiden University Medical Center, Leiden, The Netherlands; Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands; Department of Neurosurgery, Utrecht Medical Center, Utrecht, The Netherlands; Department of Neurosurgery, VU Medical Center, Amsterdam, The Netherlands; Department of Neurosurgery, Medical Center Haaglanden, The Hague, The Netherlands; Department of Neurology, Medical Center Haaglanden, The Hague, The Netherlands.
authors.forename: Wouter R
authors.initials: WR
authors.lastname: van Furth
mesh_terms: D006801:Humans; D008577:Meningeal Neoplasms / Q000523:psychology* / Q000532:radiotherapy; D008579:Meningioma / Q000523:psychology* / Q000532:radiotherapy; D011788:Quality of Life; D011795:Surveys and Questionnaires
keywords: health-related quality of life; meningioma; patient-reported outcome; questionnaires; reporting level