title: Nasal carriage of methicillin-resistantStaphylococcus pseudintermediusin dogs treated with cephalexin monohydrate.
abstract: This study aimed to investigate the nasal carriage of methicillin-resistantStaphylococcus pseudintermedius(MRSP) in dogs treated with oral cephalexin monohydrate. Ten dogs with superficial pyoderma were monitored longitudinally for carriage of MRSP for up to 1 year after treatment; the strains were typed and antibiograms were determined. Methicillin-susceptibleS. pseudintermedius(MSSP) was recovered prior to treatment in all dogs and could be isolated after 12 months in 1 dog. Methicillin-resistantStaphylococcus pseudintermediuswas detected within 1 week of treatment in all dogs, and 3 clones represented by ST45, ST112, and ST181 were consistently present for up to 12 months after treatment. All MRSP isolates were resistant to at least 7 common antimicrobials. Oral cephalexin monohydrate treatment selected for strains of multi-resistant MRSP, which were still present after 1 year.
authors.affiliation: Department of Veterinary Microbiology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, Thailand.
authors.forename: Punpichaya
authors.initials: P
authors.lastname: Fungwithaya
authors.affiliation: Department of Veterinary Microbiology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, Thailand.
authors.forename: Pattrarat
authors.initials: P
authors.lastname: Chanchaithong
authors.affiliation: Department of Veterinary Microbiology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, Thailand.
authors.forename: Nathita
authors.initials: N
authors.lastname: Phumthanakorn
authors.affiliation: Department of Veterinary Microbiology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, Thailand.
authors.forename: Nuvee
authors.initials: N
authors.lastname: Prapasarakul
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002506:Cephalexin / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy / Q000382:microbiology*; D004285:Dogs; D005260:Female; D008297:Male; D016106:Methicillin Resistance; D009666:Nose / Q000382:microbiology*; D013210:Staphylococcus / Q000145:classification / Q000302:isolation & purification*
chemical_list: D000900:Anti-Bacterial Agents; D002506:Cephalexin