title: Multidisciplinary management of a patient with van der Woude syndrome: A case report.
abstract: BACKGROUND
  Van der Woude syndrome (VWS) is the most frequent form of syndromic cleft lip and palate (SCLP) accounting for 2% of all patients with CLP.
  
  
  METHODS
  We describe the orthodontic treatment of a girl diagnosed with VWS referred by her family dentist for her cosmetic concerns.
  
  
  CONCLUSIONS
  Comprehensive orthodontic treatment, secondary bone graft, distraction osteogenesis (for a deficient maxilla), secondary palatoplasty and excision of lower lip pits, as well as orthodontic and prosthetic procedures may provide a satisfactory outcome. Genetic testing showed a known putative splice site mutation (c.174+1G/A) as the prime cause of VWS in our patient and her family.
  
  
  CONCLUSIONS
  SCLP has significant effects on facial aesthetics and the psychosocial status. Parents should be assessed and counseled appropriately. This condition is treatable in the absence of life threatening systemic anomalies. An interdisciplinary team approach is advocated.
authors.affiliation: Preventive Research Center, Research Institute of Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Orthodontic Department, Dental School, Tehran, Iran. Electronic address: azitatehranchi@yahoo.com.
authors.forename: Azita
authors.initials: A
authors.lastname: Tehranchi
authors.affiliation: Dentofacial Deformities Research Center, Research Institute of Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Dental School, Tehran, Iran. Electronic address: hosseinbehnia1@gmail.com.
authors.forename: Hossein
authors.initials: H
authors.lastname: Behnia
authors.affiliation: University of Antwerp (UA), Belgium; The Team for Cleft and Craniofacial Anomalies, Oral and Maxillofacial Surgery, University of Antwerp, Prinsstraat 13, 2000 Antwerp, Belgium. Electronic address: nasser@nadjmi.com.
authors.forename: Nasser
authors.initials: N
authors.lastname: Nadjmi
authors.affiliation: Genomic Research Center, Aarabi St., Yaman Ave., Evin, Velenjak, Shahid Beheshti University of Medical Sciences, Tehran, 1966645643, Iran; Dept. of Medical Genetic, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, 1966645643, Iran. Electronic address: v.yassaee-grc@sbmu.ac.ir.
authors.forename: Vahid Reza
authors.initials: VR
authors.lastname: Yassaee
authors.affiliation: Genomic Research Center, Aarabi St., Yaman Ave., Evin, Velenjak, Shahid Beheshti University of Medical Sciences, Tehran, 1966645643, Iran. Electronic address: zeinab.ravesh@yahoo.com.
authors.forename: Zeinab
authors.initials: Z
authors.lastname: Ravesh
authors.affiliation: North Khorasan University of Medical Sciences, Bojnurd, Iran. Electronic address: mortezamina@yahoo.com.
authors.forename: Morteza
authors.initials: M
authors.lastname: Mina
keywords: Case report; Cleft lip; Distraction osteogenesis; Maxilla; Van der Woude syndrome