title: Efficiency of endothelial dysfunctioncorrection in children residents of radioactively contaminated areas using the method of intermittent normobaric hypoxi therapy.
abstract: Objective is to evaluate the effectiveness of intermittent normobaric hypoxi therapy as the means that can posi tively influence on the different links in the pathogenesis of endothelial dysfunction in children residents of radioactively contaminated areas.
  
  
  METHODS
  Disorders of personal and emotional sphere, symptoms of asthenic vegetative and neurot ic character, the signs of the cardiovascular and respiratory systems, abdominal and dyspeptic syndromes are attrib uted to the clinical signs of endothelial dysfunction. There were determined the biochemical parameters of the con tent of stable metabolites of NO, L arginine, lipid peroxidation, antioxidant enzymes in the blood serum; the indices of cellular and humoral immunity; the instrumental indices of vascular endothelium dependent reaction to occlu sion test, ventilating ability of the lungs, the bioelectric activity of the myocardium. Intermittent normobaric hypoxi therapy (INHT) was performed using the individual device of mountain air of the «Borei» type produced by State Research Medical Engineering Center «NORT» NAS of Ukraine (Kyiv).
  
  
  CONCLUSIONS
  The clinical examination showed that the administration of additional intermittent nor mobaric hypoxi therapy to the basic treatment of 44 children with endothelial dysfunction who live in the radioac tively contaminated areas, promoted to reduce the frequency of complaints and intensity of clinical manifestations in the mentioned symptom complex. An increase of serum L arginine in the absence of significant changes in the content of NO stable metabolites was revealed in the most examined children residents of radioactively contami nated areas by studying NO system after using the course of intermittent normobaric hypoxi therapy. Positive changes in vascular endothelium dependent reaction to occlusion test, indicating the reduction length of the recovery period for thermographic circulation index after occlusive test, were determined. The decrease in the inten sity of lipid peroxidation processes - a reduction of serum LPO end products content that react with thiobarbituric acid - was observed. The bronchospasm elimination was revealed in a large number of children with the study of the lung ventilation capacity. There were trends to reduce the imbalance of different chain of the heart rhythm man agement. The immunomodulatory effect was detected as: the increase in the functional activity of neutrophils, the normalization of humoral immunity link indices. Intermittent normobaric hypoxi therapy is an effective tool that can positively affect the condition of nitric oxide system and endothelium dependent functions of the organs and systems in children residents of radioactively contaminated areas.
authors.affiliation: State Institution National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, 53 Melnykova Street, Kyiv, 04050, Ukraine.
authors.forename: Ye I
authors.initials: YI
authors.lastname: Stepanova
authors.affiliation: O. O. Bogomoletz Institute of Physiology, NAS of Ukraine, str. Bogomoletz, 4, Kyiv 01024, Ukraine.
authors.forename: V Ya
authors.initials: VY
authors.lastname: Berezovsky
authors.affiliation: State Institution National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, 53 Melnykova Street, Kyiv, 04050, Ukraine.
authors.forename: I Ye
authors.initials: IY
authors.lastname: Kolpakov
authors.affiliation: State Institution National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, 53 Melnykova Street, Kyiv, 04050, Ukraine.
authors.forename: V H
authors.initials: VH
authors.lastname: Kondrashova
authors.affiliation: State Institution National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, 53 Melnykova Street, Kyiv, 04050, Ukraine.
authors.forename: V Yu
authors.initials: VY
authors.lastname: Vdovenko
authors.affiliation: State Institution National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, 53 Melnykova Street, Kyiv, 04050, Ukraine.
authors.forename: O M
authors.initials: OM
authors.lastname: Lytvynets
authors.affiliation: O. O. Bogomoletz Institute of Physiology, NAS of Ukraine, str. Bogomoletz, 4, Kyiv 01024, Ukraine.
authors.forename: L M
authors.initials: LM
authors.lastname: Lisukha
authors.affiliation: State Institution National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, 53 Melnykova Street, Kyiv, 04050, Ukraine.
authors.forename: V M
authors.initials: VM
authors.lastname: Zyhalo
authors.affiliation: State Institution National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, 53 Melnykova Street, Kyiv, 04050, Ukraine.
authors.forename: V I
authors.initials: VI
authors.lastname: Kolos
authors.affiliation: State Institution National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, 53 Melnykova Street, Kyiv, 04050, Ukraine.
authors.forename: L P
authors.initials: LP
authors.lastname: Mishchenko
mesh_terms: D002648:Child; D006801:Humans; D027802:Hypoxis; D015227:Lipid Peroxidation; D008297:Male; D009569:Nitric Oxide; D012119:Respiration; D014455:Ukraine
chemical_list: D009569:Nitric Oxide
keywords: children; correction hypoxi therapy; endothelial dysfunction; radioactively contaminated territories