title: Different origins of lysophospholipid mediators between coronary and peripheral arteries in acute coronary syndrome.
abstract: Lysophosphatidic acids (LysoPAs) and lysophosphatidylserine (LysoPS) are emerging lipid mediators proposed to be involved in the pathogenesis of acute coronary syndrome (ACS). In this study, we attempted to elucidate how LysoPA and LysoPS become elevated in ACS using human blood samples collected simultaneously from culprit coronary arteries and peripheral arteries in ACS subjects. We found that: 1) the plasma LysoPA, LysoPS, and lysophosphatidylglycerol levels were not different, while the lysophosphatidylcholine (LysoPC), lysophosphatidylinositol, and lysophosphatidylethanolamine (LysoPE) levels were significantly lower in the culprit coronary arteries; 2) the serum autotaxin (ATX) level was lower and the serum phosphatidylserine-specific phospholipase A1(PS-PLA1) level was higher in the culprit coronary arteries; 3) the LysoPE and ATX levels were significant explanatory factors for the mainly elevated species of LysoPA, except for 22:6 LysoPA, in the peripheral arteries, while the LysoPC and LysoPE levels, but not the ATX level, were explanatory factors in the culprit coronary arteries; and 4) 18:0 and 18:1 LysoPS were significantly correlated with PS-PLA1only in the culprit coronary arteries. In conclusion, the origins of LysoPA and LysoPS might differ between culprit coronary arteries and peripheral arteries, and substrates for ATX, such as LysoPC and LysoPE, might be important for the generation of LysoPA in ACS.
authors.affiliation: Department of Clinical Laboratory Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.|CREST, Japan Science and Technology Corporation (JST).
authors.forename: Makoto
authors.initials: M
authors.lastname: Kurano
authors.affiliation: CREST, Japan Science and Technology Corporation (JST).|Laboratory of Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Miyagi, Japan.
authors.forename: Kuniyuki
authors.initials: K
authors.lastname: Kano
authors.affiliation: Department of Cardiovascular Medicine, Juntendo University School of Medicine, Tokyo, Japan.
authors.forename: Tomotaka
authors.initials: T
authors.lastname: Dohi
authors.affiliation: Laboratory of Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Miyagi, Japan.
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Matsumoto
authors.affiliation: Bioscience Division, Reagent Development Department, AIA Research Group, TOSOH Corporation, Kanagawa, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Igarashi
authors.affiliation: Department of Clinical Laboratory Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.|CREST, Japan Science and Technology Corporation (JST).
authors.forename: Masako
authors.initials: M
authors.lastname: Nishikawa
authors.affiliation: Department of Clinical Laboratory, University of Tokyo Hospital, Tokyo, Japan.
authors.forename: Ryunosuke
authors.initials: R
authors.lastname: Ohkawa
authors.affiliation: Department of Clinical Laboratory Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.|CREST, Japan Science and Technology Corporation (JST).|Department of Clinical Laboratory, University of Tokyo Hospital, Tokyo, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ikeda
authors.affiliation: Department of Cardiovascular Medicine, Juntendo University School of Medicine, Tokyo, Japan.
authors.forename: Katsumi
authors.initials: K
authors.lastname: Miyauchi
authors.affiliation: Department of Cardiovascular Medicine, Juntendo University School of Medicine, Tokyo, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Daida
authors.affiliation: CREST, Japan Science and Technology Corporation (JST).|Laboratory of Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Miyagi, Japan.
authors.forename: Junken
authors.initials: J
authors.lastname: Aoki
authors.affiliation: Department of Clinical Laboratory Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan yatoyuta-tky@umin.ac.jp.|CREST, Japan Science and Technology Corporation (JST).|Department of Clinical Laboratory, University of Tokyo Hospital, Tokyo, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yatomi
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood* / Q000473:pathology; D050197:Atherosclerosis / Q000097:blood* / Q000378:metabolism / Q000473:pathology; D003331:Coronary Vessels / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006321:Heart / Q000503:physiopathology; D006801:Humans; D008246:Lysophospholipids / Q000097:blood*; D008297:Male; D013058:Mass Spectrometry; D054466:Phospholipases A1 / Q000097:blood; D010727:Phosphoric Diester Hydrolases / Q000097:blood; D000099189:Lysophospholipase D
chemical_list: D008246:Lysophospholipids; D054466:Phospholipases A1; D010727:Phosphoric Diester Hydrolases; D000099189:Lysophospholipase D; C026223:lysophosphatidylglycerol; C025449:lysophosphatidylinositol; C025059:lysophosphatidylserine
keywords: acute coronary disease; lysophosphatidic acids; lysophosphatidylcholine; lysophosphatidylethanolamine; lysophosphatidylserine