title: The effect of vitamin D supplementation on pain, quality of life, and nerve conduction studies in women with chronic widespread pain.
abstract: The aim of this study was to investigate the effects of vitamin D supplementation on pain, quality of life, and nerve conduction studies (NCSs) in women with chronic widespread pain (CWP) diagnosed with Vitamin D insufficiency. Thirty-three female participants with CWP and vitamin D insufficiency were included in this open-label trial. They were evaluated by routine NCSs in upper and lower limbs, pain scales, and the Nottingham Health Profile before and 8 weeks after starting vitamin D supplementation therapy. The P-value was adjusted to account for the number of comparisons performed in each assessment. After 8 weeks of treatment, participants reported significantly lower pain scores (P=0.000). The total Nottingham Health Profile score and subscores for pain, emotional reactions, and physical activity domains were significantly lower (0.000≤P≤0.008). However, no statistically significant changes in NCSs were detected, except trends toward increases in the amplitudes of left median and ulnar sensory nerve potentials and a decrease in the distal latency of the right median sensory potential (0.01≤P≤0.04). Vitamin D supplementation therapy decreased pain and increased quality of life without significantly affecting nerve conduction in patients with CWP.
authors.affiliation: Departments of aPhysical Medicine and Rehabilitation bPhysiology, Marmara University, School of Medicine cDepartment of Neurosurgery, Fatih Sultan Mehmet Education and Research Hospital, University of Health Sciences, Turkish Ministry of Health, Istanbul, Turkey.
authors.forename: Gulseren
authors.initials: G
authors.lastname: Akyuz
authors.forename: Canan
authors.initials: C
authors.lastname: Sanal-Toprak
authors.forename: Ilker
authors.initials: I
authors.lastname: Yagci
authors.forename: Esra
authors.initials: E
authors.lastname: Giray
authors.forename: Pinar
authors.initials: P
authors.lastname: Kuru-Bektasoglu
mesh_terms: D000293:Adolescent; D000328:Adult; D059350:Chronic Pain / Q000523:psychology / Q000628:therapy*; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D009431:Neural Conduction; D011788:Quality of Life; D064232:Visual Analog Scale; D014807:Vitamin D / Q000008:administration & dosage*; D014808:Vitamin D Deficiency / Q000188:drug therapy; D014815:Vitamins / Q000008:administration & dosage*; D055815:Young Adult
chemical_list: D014815:Vitamins; D014807:Vitamin D