title: Haploidentical hematopoietic cell transplantation for disseminated Ewing sarcoma.
abstract: We describe the case of a 13-year-old girl with multifocal disseminated Ewing sarcoma family of tumor (ESFT) who received a 5/8 human leukocyte antigen-matched haploidentical hematopoietic cell transplantation to generate a graft-versus-tumor effect. The patient had grade 2 acute graft-versus-host disease (GVHD) of the skin and chronic GVHD nausea and abdominal pain that required prednisolone for 17 months, but has been free from ESFT for 3 years 10 months after therapy. The present case suggests a beneficial effect of haploidentical hematopoietic cell transplantation in disseminated ESFT.
authors.affiliation: Department of Pediatrics, St Luke's International Hospital, Tokyo, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Yoshihara
authors.affiliation: Department of Hemato-Oncology, St Luke's International Hospital, Tokyo, Japan.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Kumamoto
authors.affiliation: Department of Pediatrics, St Luke's International Hospital, Tokyo, Japan.
authors.forename: Rintaro
authors.initials: R
authors.lastname: Ono
authors.affiliation: Department of Radiation Oncology, St Luke's International Hospital, Tokyo, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Akahane
authors.affiliation: Department of Radiology, St Luke's International Hospital, Tokyo, Japan.
authors.forename: Taiki
authors.initials: T
authors.lastname: Nozaki
authors.affiliation: Department of Pediatric Oncology, Fukushima Medical University, Fukushima, Japan.
authors.forename: Shogo
authors.initials: S
authors.lastname: Kobayashi
authors.affiliation: Department of Pediatric Oncology, Fukushima Medical University, Fukushima, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kikuta
authors.affiliation: Department of Orthopaedic Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.
authors.forename: Seiichi
authors.initials: S
authors.lastname: Matsumoto
authors.affiliation: Department of Pediatrics, St Luke's International Hospital, Tokyo, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Hasegawa
authors.affiliation: Department of Pediatrics, St Luke's International Hospital, Tokyo, Japan.
authors.forename: Chitose
authors.initials: C
authors.lastname: Ogawa
authors.affiliation: Department of Pediatrics, St Luke's International Hospital, Tokyo, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Manabe
mesh_terms: D000293:Adolescent; D001859:Bone Neoplasms / Q000628:therapy*; D005260:Female; D006086:Graft vs Host Disease; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D010384:Pelvic Bones; D012512:Sarcoma, Ewing / Q000628:therapy*
keywords: Ewing sarcoma; graft-versus-host disease; graft-versus-tumor effect; hematopoietic stem cell transplantation; killer cell immunoglobulin-like receptor