title: Platelets miRNA as a Prediction Marker of Thrombotic Episodes.
abstract: The blood platelets are crucial for the coagulation physiology to maintain haemostatic balance and are involved in various pathologies such as atherosclerosis and thrombosis. The studies of recent years have shown that anucleated platelets are able to succeed protein synthesis. Additionally, mRNA translation in blood platelets is regulated by miRNA molecules. Recent works postulate the possibility of using miRNAs as biomarkers of atherosclerosis and ischemic episodes. This review article describes clinical studies that presented blood platelets miRNAs expression profile changes in different thrombotic states, which suggest use of these molecules as predictive biomarkers.
authors.affiliation: Department of General Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland.
authors.forename: Michal
authors.identifier: 0000-0002-7838-4097
authors.initials: M
authors.lastname: Bijak
authors.affiliation: Intensive Cardiac Therapy Clinic, Medical University of Lodz, Pomorska 251, 91-213 Lodz, Poland.
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Dzieciol
authors.affiliation: Department of General Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland.
authors.forename: Joanna
authors.identifier: 0000-0001-8895-7082
authors.initials: J
authors.lastname: Rywaniak
authors.affiliation: Department of General Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland.
authors.forename: Joanna
authors.identifier: 0000-0002-1455-443X
authors.initials: J
authors.lastname: Saluk
authors.affiliation: Intensive Cardiac Therapy Clinic, Medical University of Lodz, Pomorska 251, 91-213 Lodz, Poland.
authors.forename: Marzenna
authors.identifier: 0000-0002-0118-8610
authors.initials: M
authors.lastname: Zielinska
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D001792:Blood Platelets / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D013927:Thrombosis / Q000097:blood*
chemical_list: D015415:Biomarkers; D035683:MicroRNAs