title: The effect of Searsia chirindensis stem-bark extract on renal and liver function in a rat model of neurotoxicity.
abstract: Searsia chirindensis (SC) (Baker F.) (Anacardiaceae) has shown potential for the treatment of many neurological diseases however its effect on other bodily systems in neurotoxic models is not well-documented. In this study we investigated the effects of SC on blood glucose homeostasis, as well as its effect on liver and kidney function by assessing lipid peroxidation using the TBARS assay and measuring plasma and urinary electrolyte concentrations in a 6-hydroxydopamine parkinsonian model. The relative levels of phytochemicals were also quantified, along with testing free radical scavenging activity via the DPPH assay. Our results showed that SC decreases blood glucose levels but did not alter the liver and kidney function as reflected by the absence of electrolyte imbalances and lipid peroxidation damage. We also found that SC comprises primarily phenolic acids (945.73±154.01mg GA/g SC) and triterpenoids (1997.21±404.04mg OA/g SC) with minimal flavonoid content (12.98±2.75mg Q/g SC) and exhibited strong free radical scavenging activity (≈80%). In conclusion, these results suggest that SC does not alter the renal and liver function at least in the different parameters studied.
authors.affiliation: Discipline of Human Physiology, School of Laboratory and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban 4000, South Africa.
authors.forename: Zulfiah Mohamed
authors.initials: ZM
authors.lastname: Moosa
authors.affiliation: Discipline of Human Physiology, School of Laboratory and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban 4000, South Africa. Electronic address: mabandlam@ukzn.ac.za.
authors.forename: Musa
authors.initials: M
authors.lastname: Mabandla
mesh_terms: D027926:Anacardiaceae / Q000737:chemistry*; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D005419:Flavonoids / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects*; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects*; D008297:Male; D020258:Neurotoxicity Syndromes / Q000188:drug therapy*; D010636:Phenols / Q000494:pharmacology; D024301:Plant Bark / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D018547:Plant Stems / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014315:Triterpenes / Q000494:pharmacology
chemical_list: D001786:Blood Glucose; D005419:Flavonoids; D016166:Free Radical Scavengers; D010636:Phenols; D010936:Plant Extracts; D014315:Triterpenes
keywords: Electrolytes; Flavonoids; Free radical scavenging; Phenolic acids; Searsia chirindensis; Triterpenoids