title: Cytoreduction and hyperthermic intraperitoneal chemotherapy (CS/HIPEC) in colorectal cancer: Evidence-based review of patient selection and treatment algorithms.
abstract: Cytoreduction and heated intraperitoneal chemotherapy (CS/HIPEC) is increasingly utilized as a treatment strategy for patients with peritoneal metastases from various primary tumor sites. For this heterogenous procedure, related to patient characteristics, patient selection, and the extent of surgical completeness of cytoreduction, high level evidence (ex: multiple randomized controlled trials) is not available to support efficacy. This review of the available literature supporting application of the procedure, focusing on colorectal cancer, provides a summary of current evidence for patient selection and treatment algorithms based on patient presentation.
authors.affiliation: Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, NY, USA.
authors.forename: A H
authors.initials: AH
authors.lastname: Maciver
authors.affiliation: Department of Internal Medicine, Robert Wood Johnson University Hospital, New Brunswick, NJ, USA.
authors.forename: N
authors.initials: N
authors.lastname: Lee
authors.affiliation: Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, NY, USA.
authors.forename: J J
authors.initials: JJ
authors.lastname: Skitzki
authors.affiliation: Department of Medical Oncology, Roswell Park Cancer Institute, Buffalo, NY, USA.
authors.forename: P M
authors.initials: PM
authors.lastname: Boland
authors.affiliation: Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, NY, USA. Electronic address: valerie.francescutti@roswellpark.org.
authors.forename: V
authors.initials: V
authors.lastname: Francescutti
mesh_terms: D000230:Adenocarcinoma / Q000556:secondary / Q000628:therapy*; D000465:Algorithms; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D015179:Colorectal Neoplasms / Q000473:pathology / Q000628:therapy*; D065426:Cytoreduction Surgical Procedures / Q000379:methods*; D019317:Evidence-Based Medicine; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D007263:Infusions, Parenteral; D018579:Patient Selection; D010534:Peritoneal Neoplasms / Q000556:secondary / Q000628:therapy*
keywords: Carcinomatosis; Chemoperfusion; Colorectal cancer; Cytoreduction; HIPEC