title: Abnormal brain functional connectivity leads to impaired mood and cognition in hyperthyroidism: a resting-state functional MRI study.
abstract: Patients with hyperthyroidism frequently have neuropsychiatric complaints such as lack of concentration, poor memory, depression, anxiety, nervousness, and irritability, suggesting brain dysfunction. However, the underlying process of these symptoms remains unclear. Using resting-state functional magnetic resonance imaging (rs-fMRI), we depicted the altered graph theoretical metric degree centrality (DC) and seed-based resting-state functional connectivity (FC) in 33 hyperthyroid patients relative to 33 healthy controls. The peak points of significantly altered DC between the two groups were defined as the seed regions to calculate FC to the whole brain. Then, partial correlation analyses were performed between abnormal DC, FC and neuropsychological performances, as well as some clinical indexes. The decreased intrinsic functional connectivity in the posterior lobe of cerebellum (PLC) and medial frontal gyrus (MeFG), as well as the abnormal seed-based FC anchored in default mode network (DMN), attention network, visual network and cognitive network in this study, possibly constitutes the latent mechanism for emotional and cognitive changes in hyperthyroidism, including anxiety and impaired processing speed.
authors.affiliation: Department of Endocrinology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, 210009, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Endocrinology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, 210009, China.
authors.forename: Mengmeng
authors.initials: M
authors.lastname: Zhi
authors.affiliation: Department of Psychosomatics and Psychiatry, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, 210009, China.
authors.forename: Zhenghua
authors.initials: Z
authors.lastname: Hou
authors.affiliation: Department of Psychosomatics and Psychiatry, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, 210009, China.
authors.forename: Yuqun
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Psychosomatics and Psychiatry, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, 210009, China.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Yue
authors.affiliation: Department of Psychosomatics and Psychiatry, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, 210009, China.|Neuropsychiatric Institute, Affiliated ZhongDa Hospital, Southeast University, Nanjing, Jiangsu, 210009, China.
authors.forename: Yonggui
authors.initials: Y
authors.lastname: Yuan
mesh_terms: D000293:Adolescent; D000328:Adult; D000339:Affect; D001288:Attention; D001921:Brain / Q000000981:diagnostic imaging* / Q000503:physiopathology; D001931:Brain Mapping / Q000379:methods*; D016022:Case-Control Studies; D002531:Cerebellum / Q000000981:diagnostic imaging / Q000503:physiopathology; D003071:Cognition; D003072:Cognition Disorders / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology / Q000523:psychology; D003430:Cross-Sectional Studies; D004644:Emotions; D056344:Executive Function; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000150:complications*; D008279:Magnetic Resonance Imaging; D008297:Male; D061212:Memory, Episodic; D008875:Middle Aged; D019964:Mood Disorders / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology / Q000523:psychology; D009483:Neuropsychological Tests; D011237:Predictive Value of Tests; D017397:Prefrontal Cortex / Q000000981:diagnostic imaging / Q000503:physiopathology; D014795:Visual Pathways / Q000000981:diagnostic imaging / Q000503:physiopathology; D014796:Visual Perception; D055815:Young Adult
keywords: cognition; degree centrality; emotion; functional connectivity; hyperthyroidism