title: Brain-derived neurotrophic factor plasma levels and premature cognitive impairment/dementia in type 2 diabetes.
abstract: OBJECTIVE
  To assess the relationship of brain-derived neurotrophic factor (BDNF) with cognitive impairment in patients with type 2 diabetes.
  
  
  METHODS
  The study included 40 patients with diabetes mellitus type 2 (DM2), 37 patients with chronic kidney disease in hem dialysis hemodialysis therapy (HD) and 40 healthy subjects. BDNF in serum was quantified by ELISA. The Folstein Mini-Mental State Examination was used to evaluate cognitive impairment.
  
  
  RESULTS
  The patients with DM2 and the patients in HD were categorized into two groups, with cognitive impairment and without cognitive impairment. The levels of BDNF showed significant differences between patients with DM2 (43.78 ± 9.05vs31.55 ± 10.24,P= 0.005). There were no differences between patients in HD (11.39 ± 8.87vs11.11 ± 10.64P= 0.77); interestingly, ferritin levels were higher in patients with cognitive impairment (1564 ± 1335vs664 ± 484P= 0.001). The comparison of BDNF values, using a Kruskal Wallis test, between patients with DM2, in HD and healthy controls showed statistical differences (P< 0.001).
  
  
  CONCLUSIONS
  Low levels of BDNF are associated with cognitive impairment in patients with DM2. The decrease of BDNF occurs early and progressively in patients in HD.
authors.affiliation: Blanca Murillo Ortíz, Edna Ramos-Rodríguez, Sandra Martínez-Garza, Hilda Macías-Cervantes, Sergio Solorio-Meza, Texar Alfonso Pereyra-Nobara, Unidad de Investigación en Epidemiología Clínica, Unidad Médica de Alta Especialidad No. 1 Bajio, Instituto Mexicano del Seguro Social, Guanajuato 37320, Mexico.
authors.forename: Blanca
authors.initials: B
authors.lastname: Murillo Ortíz
authors.affiliation: Blanca Murillo Ortíz, Edna Ramos-Rodríguez, Sandra Martínez-Garza, Hilda Macías-Cervantes, Sergio Solorio-Meza, Texar Alfonso Pereyra-Nobara, Unidad de Investigación en Epidemiología Clínica, Unidad Médica de Alta Especialidad No. 1 Bajio, Instituto Mexicano del Seguro Social, Guanajuato 37320, Mexico.
authors.forename: Joel
authors.initials: J
authors.lastname: Ramírez Emiliano
authors.affiliation: Blanca Murillo Ortíz, Edna Ramos-Rodríguez, Sandra Martínez-Garza, Hilda Macías-Cervantes, Sergio Solorio-Meza, Texar Alfonso Pereyra-Nobara, Unidad de Investigación en Epidemiología Clínica, Unidad Médica de Alta Especialidad No. 1 Bajio, Instituto Mexicano del Seguro Social, Guanajuato 37320, Mexico.
authors.forename: Edna
authors.initials: E
authors.lastname: Ramos-Rodríguez
authors.affiliation: Blanca Murillo Ortíz, Edna Ramos-Rodríguez, Sandra Martínez-Garza, Hilda Macías-Cervantes, Sergio Solorio-Meza, Texar Alfonso Pereyra-Nobara, Unidad de Investigación en Epidemiología Clínica, Unidad Médica de Alta Especialidad No. 1 Bajio, Instituto Mexicano del Seguro Social, Guanajuato 37320, Mexico.
authors.forename: Sandra
authors.initials: S
authors.lastname: Martínez-Garza
authors.affiliation: Blanca Murillo Ortíz, Edna Ramos-Rodríguez, Sandra Martínez-Garza, Hilda Macías-Cervantes, Sergio Solorio-Meza, Texar Alfonso Pereyra-Nobara, Unidad de Investigación en Epidemiología Clínica, Unidad Médica de Alta Especialidad No. 1 Bajio, Instituto Mexicano del Seguro Social, Guanajuato 37320, Mexico.
authors.forename: Hilda
authors.initials: H
authors.lastname: Macías-Cervantes
authors.affiliation: Blanca Murillo Ortíz, Edna Ramos-Rodríguez, Sandra Martínez-Garza, Hilda Macías-Cervantes, Sergio Solorio-Meza, Texar Alfonso Pereyra-Nobara, Unidad de Investigación en Epidemiología Clínica, Unidad Médica de Alta Especialidad No. 1 Bajio, Instituto Mexicano del Seguro Social, Guanajuato 37320, Mexico.
authors.forename: Sergio
authors.initials: S
authors.lastname: Solorio-Meza
authors.affiliation: Blanca Murillo Ortíz, Edna Ramos-Rodríguez, Sandra Martínez-Garza, Hilda Macías-Cervantes, Sergio Solorio-Meza, Texar Alfonso Pereyra-Nobara, Unidad de Investigación en Epidemiología Clínica, Unidad Médica de Alta Especialidad No. 1 Bajio, Instituto Mexicano del Seguro Social, Guanajuato 37320, Mexico.
authors.forename: Texar Alfonso
authors.initials: TA
authors.lastname: Pereyra-Nobara
keywords: Brain-derived neurotrophic factor; Diabetes mellitus type 2; Folstein mini-mental; Hemodialysis; Premature cognitive impairment