title: An atypical sarcoidosis involvement in FDG PET/CT: A case report.
abstract: BACKGROUND
  Sarcoidosis is an idiopathic systemic inflammatory granulomatous disorder comprised of epithelioid and multinucleated giant cells with little necrosis which involve various organs. Laryngeal involvement is extremely rare, with a prevalence of about 0.5 to 1%.
  
  
  METHODS
  Here we present a case of laryngeal involvement of sarcoidosis demonstrated on F-Fluorodesoxyglucose Positron-Emission Tomography/Computed Tomography (FDG PET/CT).
  
  
  METHODS
  A 63 year-old man suffering from dysphonia was referred to our department for characterization of laryngeal lesion suspicious for cancer with non-informative biopsy, the sample was not sufficient for diagnosis.
  
  
  METHODS
  FDG PET/CT showed a pathological uptake on the right vocal cord, but also highlighted a bilateral uptake in intrathoracic hilar lymphadenopathy areas, typically found in several inflammatory diseases.
  
  
  RESULTS
  New laryngeal targeted biopsies revealed non-caseating epithelioid granulomas suggesting sarcoidosis involvement. After 6 months of systemic steroid treatment, FDG PET/CT showed a significant decrease of the laryngeal uptake.
  
  
  CONCLUSIONS
  This case shows the usefulness of FDG PET/CT to accurately assess inflammatory activity in rare extra-pulmonary sarcoidosis involvement. Moreover, this case emphasizes that FDG PET/CT is an interesting tool for assessing therapeutic efficacy of inflammatory diseases such as sarcoidosis.
authors.affiliation: Département de Médecine Nucléaire, EA3878 (GETBO) IFR 148, Centre Hospitalier Régional Universitaire de Brest, France Département d'Anatomie Pathologique, Centre Hospitalier Régional Universitaire de Brest Service d'Oto-Rhino-Laryngologie, Clinique Pasteur, Brest, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Robin
authors.forename: Paolo
authors.initials: P
authors.lastname: Benigni
authors.forename: Benoit
authors.initials: B
authors.lastname: Feger
authors.forename: Pierre-Yves
authors.initials: PY
authors.lastname: Salaun
authors.forename: Ronan
authors.initials: R
authors.lastname: Abgral
mesh_terms: D019788:Fluorodeoxyglucose F18 / Q000627:therapeutic use; D006801:Humans; D007818:Laryngeal Diseases / Q000000981:diagnostic imaging* / Q000473:pathology; D007830:Larynx / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008875:Middle Aged; D000072078:Positron Emission Tomography Computed Tomography; D012507:Sarcoidosis / Q000000981:diagnostic imaging* / Q000473:pathology
chemical_list: D019788:Fluorodeoxyglucose F18