title: Mallory Weiss syndrome is not associated with hiatal hernia: a matched case-control study.
abstract: OBJECTIVE
  Hiatal hernia is considered to be a predisposing factor to develop Mallory-Weiss Syndrome (MWS). No large case-control studies verifying this hypothesis have been conducted.
  
  
  METHODS
  We reviewed all esophagogastroduodenoscopies with findings of MWS (n = 2342) in a national database and compared with age and gender-matched controls (n = 9368). Demographics, endoscopic characteristics and presence of a hiatal hernia were compared between both groups. Average age was 56.7 ± 18.6 years, and 72.4% were male.
  
  
  RESULTS
  Hiatal hernia was more common in controls, and no significant difference was seen in a multivariate analysis.
  
  
  CONCLUSIONS
  Dynamic changes inducing mucosal tension are more relevant determinants to develop MWS than gastro-esophageal junction location alone.
authors.affiliation: a Division of Gastroenterology and Hepatology , Mayo Clinic , Jacksonville , FL , USA.
authors.forename: Juan E
authors.initials: JE
authors.lastname: Corral
authors.affiliation: b Department of Medicine , University of Miami Miller School of Medicine - Jackson Memorial Hospital , Miami , FL , USA.
authors.forename: Tara
authors.initials: T
authors.lastname: Keihanian
authors.affiliation: c Department of Medicine , Mount Sinai, St. Luke's, and Roosevelt Hospitals, Icahn School of Medicine at Mount Sinai , New York , NY , USA.
authors.forename: Paul T
authors.initials: PT
authors.lastname: Kröner
authors.affiliation: b Department of Medicine , University of Miami Miller School of Medicine - Jackson Memorial Hospital , Miami , FL , USA.
authors.forename: Ryan
authors.initials: R
authors.lastname: Dauer
authors.affiliation: a Division of Gastroenterology and Hepatology , Mayo Clinic , Jacksonville , FL , USA.
authors.forename: Frank J
authors.initials: FJ
authors.lastname: Lukens
authors.affiliation: d Division of Gastroenterology, Department of Medicine , University of Miami Miller School of Medicine , Miami , FL , USA.
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Sussman
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D016208:Databases, Factual; D016145:Endoscopy, Digestive System; D004943:Esophagogastric Junction / Q000473:pathology; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology*; D006551:Hernia, Hiatal / Q000453:epidemiology*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008309:Mallory-Weiss Syndrome / Q000150:complications*; D008875:Middle Aged; D009092:Mucous Membrane / Q000473:pathology; D015999:Multivariate Analysis; D014481:United States
keywords: Mallory Weiss; esophagus; gastrointestinal bleeding; hiatal hernia