title: Bug Smash, Bug Splash: A Case Report of an Unusual Transmission of American Trypanosomiasis with a Brief Review of the Literature.
abstract: BACKGROUND Chagas disease is a chronic parasitosis transmitted by the inoculation of infected triatomine feces into wounds or conjunctival sac, transfusion, congenitally, organ transplantation, and ingestion of contaminated food. The disease is classified into an acute and chronic phase; the latter is a life-long infection that can be asymptomatic or progress to cardiac or digestive complications. CASE REPORT We report a case of acute-phase Chagas disease, transmitted by the splash of gut content from an infected triatomine into the conjunctival mucosa. CONCLUSIONS The diagnosis of Chagas disease is made by the direct visualization of the parasite in blood smears during the acute phase of the disease; during the chronic phase of the disease the diagnosis is made by the detection of IgG antibodies. Parasitological cure can be achieved in up to 80% of the cases in acute phase of the disease, in contrast with less than 30% during the chronic phase.
authors.affiliation: Department of Infectious Diseases, Hospital General de Cuernavaca "Dr. José G. Parres", Cuernavaca, Mexico.
authors.forename: Rafael Hernán
authors.initials: RH
authors.lastname: Navarrete-Sandoval
authors.affiliation: Faculty of Medicine, Universidad Autónoma del Estado de Morelos, Cuernavaca, Mexico.
authors.forename: Maximiliano
authors.initials: M
authors.lastname: Servín-Rojas
mesh_terms: D000328:Adult; D000818:Animals; D014355:Chagas Disease / Q000175:diagnosis* / Q000469:parasitology / Q000635:transmission*; D004487:Edema / Q000469:parasitology; D005334:Fever / Q000469:parasitology; D006261:Headache / Q000469:parasitology; D006801:Humans; D008297:Male; D058069:Neglected Diseases; D009547:Nifurtimox / Q000627:therapeutic use*; D016896:Treatment Outcome; D014225:Triatominae / Q000469:parasitology; D014344:Trypanocidal Agents / Q000627:therapeutic use*; D014349:Trypanosoma cruzi / Q000469:parasitology*
chemical_list: D014344:Trypanocidal Agents; D009547:Nifurtimox