title: [Epidemiology and risk factors of patients with intra-abdominal postsurgical infection treated with tigecycline: a cohort study].
abstract: OBJECTIVE
  To study a cohort of patients with intra-abdominal postsurgical infection treated with tigecycline to analyze its effectiveness and mortality related factors.
  
  
  METHODS
  Prospective study of patients with intra-abdominal postsurgical infection with microbiological isolation and treated with tigecycline.
  
  
  RESULTS
  Out of 103 patients only 61 full fit inclusion criteria. Mean age was 67 year-old and 72% were male. Charlson score was ≥ 3 in 65.5%, being diabetes and colon cancer the most prevalent diseases. Cancer surgery was the most frequent procedure (n=44, 72%) and previous antibiotic administration was present in 43 cases (69%). Pitt score was ≥ 3 in 69% and most prevalent bacteria were Escherichia coli (38 %), Enterococcus spp. (34%; mainly Enterococcus faecium) and Klebsiella pneumoniae together with Enterobacter cloacae (28%). Tigecycline was prescribed alone (17; 28%) or in combination with other antibiotics (44; 72%), mainly meropenem (25; 57%) or amikacin (19, 43%). 11 patients died (18%), all of which suffered extended cancer surgery and isolation of extended-spectrum betalactamase producing Enterobacteriaceae. Factors statistically associated to death in univariate analysis were Charlson score >3, pH <7.3 and leucocyte count >20.000 cells/mm3.
  
  
  CONCLUSIONS
  As being a cohort of patients treated with tigecycline, E. faecium isolation was very frequent. Non-fatal evolution was achieved in 82% cases, being tigecycline a potentially good option in the empiric treatment of very severe infections.
authors.forename: G
authors.initials: G
authors.lastname: Torres
authors.forename: M
authors.initials: M
authors.lastname: Paredes
authors.forename: A
authors.initials: A
authors.lastname: Hernández
authors.forename: C
authors.initials: C
authors.lastname: García
authors.forename: F
authors.initials: F
authors.lastname: Sánchez Bueno
authors.forename: M
authors.initials: M
authors.lastname: Canteras
authors.forename: P
authors.initials: P
authors.lastname: Parrilla
authors.affiliation: Joaquín Gómez, Servicio de Medicina Interna-Infecciosas del HCUVA. Departamento de Medicina Interna. Facultad de Medicina Universidad de Murcia. IMIB Arrixaca.
authors.forename: J
authors.initials: J
authors.lastname: Gómez
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D015331:Cohort Studies; D024901:Drug Resistance, Multiple, Bacterial; D004756:Enterobacteriaceae Infections / Q000382:microbiology; D005260:Female; D006801:Humans; D059413:Intraabdominal Infections / Q000188:drug therapy* / Q000453:epidemiology* / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D008911:Minocycline / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011183:Postoperative Complications / Q000188:drug therapy* / Q000453:epidemiology* / Q000382:microbiology; D011446:Prospective Studies; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology; D000078304:Tigecycline
chemical_list: D000900:Anti-Bacterial Agents; D000078304:Tigecycline; D008911:Minocycline