title: Fifty Years of Research in ARDS. Is Acute Respiratory Distress Syndrome a Preventable Disease?
abstract: Despite significant advances in our understanding and management of patients with acute respiratory distress syndrome (ARDS), the morbidity and mortality from ARDS remains high. Given the limited number of effective treatments for established ARDS, the strategic focus of ARDS research has shifted toward identifying patients with or at high risk of ARDS early in the course of the underlying illness, when strategies to reduce the development and progression of ARDS and associated organ failures can be systematically evaluated. In this review, we summarize the rationale, current evidence, and future directions in ARDS prevention.
authors.affiliation: 1 Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota; and.
authors.forename: Hemang
authors.identifier: 0000-0002-1889-2524
authors.initials: H
authors.lastname: Yadav
authors.affiliation: 2 Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, Massachusetts.
authors.forename: B Taylor
authors.initials: BT
authors.lastname: Thompson
authors.affiliation: 1 Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota; and.
authors.forename: Ognjen
authors.initials: O
authors.lastname: Gajic
mesh_terms: D035843:Biomedical Research; D006801:Humans; D011322:Primary Prevention / Q000379:methods*; D012128:Respiratory Distress Syndrome / Q000503:physiopathology / Q000517:prevention & control* / Q000628:therapy; D055502:Secondary Prevention / Q000379:methods*
keywords: acute lung injury; acute respiratory distress syndrome; prevention; respiratory failure