title: TIA-1 Is a Functional Prion-Like Protein.
abstract: Prions are self-propagating protein conformations that are traditionally regarded as agents of neurodegenerative disease in animals. However, it has become evident that prion-like aggregation of endogenous proteins can also occur under normal physiological conditions (e.g., during memory storage or activation of the immune response). In this review, we focus on the functional prion-related protein TIA-1, an RNA-binding protein that is involved in multiple aspects of RNA metabolism but is best understood in terms of its role in stress granule assembly during the cellular stress response. We propose that stress granule formation provides a useful conceptual framework with which to address the positive role of TIA-1 prion-like aggregation. Elucidating the function of TIA-1 prion-like aggregation will advance our understanding of how prion-based molecular switches are used in normal physiological settings.
authors.affiliation: Department of Neuroscience, College of Physicians and Surgeons of Columbia University, New York, New York 10032.
authors.forename: Joseph B
authors.initials: JB
authors.lastname: Rayman
authors.affiliation: Department of Neuroscience, College of Physicians and Surgeons of Columbia University, New York, New York 10032.|Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, New York 10032.|Howard Hughes Medical Institute at Columbia University, New York, New York 10032.|Zuckerman Mind Brain Behavior Institute, Columbia University, New York, New York 10032.|Kavli Institute for Brain Science, Columbia University, New York, New York 10032.
authors.forename: Eric R
authors.initials: ER
authors.lastname: Kandel
mesh_terms: D000818:Animals; D006801:Humans; D008568:Memory / Q000502:physiology; D019636:Neurodegenerative Diseases / Q000503:physiopathology; D011328:Prions / Q000378:metabolism*; D000074019:T-Cell Intracellular Antigen-1 / Q000378:metabolism*
chemical_list: D011328:Prions; D000074019:T-Cell Intracellular Antigen-1; C071558:TIA1 protein, human