title: Patients with dental calculus have increased saliva and gingival crevicular fluid fetuin-A levels but no association with fetuin-A polymorphisms.
abstract: Fetuin-A is a potent inhibitor of calcium-phosphate precipitation and of the calcification process, therefore it can also be related with dental calculus. Thus, we aimed to investigate a possible relationship between fetuin-A gene polymorphism and the presence of dental calculus. A possible relationship between serum, saliva and gingival crevicular fluid (GCF) levels of fetuin-A was also investigated. Fetuin-A c.742C > T and c.766C > G polymorphisms were investigated in 103 patients with or without dental calculus. Additionally, serum, saliva and GCF fetuin-A levels of patients were compared according to dental calculus presence. A significant difference was not observed in the distribution of the fetuin-A c.742C > T and c.766C > G polymorphisms between patients with or without dental calculus. Saliva and GCF fetuin-A concentrations of patients with dental calculus were statistically higher than those without dental calculus (P=0.001, P=0.036 respectively). According to our results, fetuin-A c.742C > T and c.766C > G polymorphisms were not associated with presence of dental calculus. However, higher GCF and saliva fetuin-A levels were detected in patients with dental calculus than in patients without dental calculus, which may result from an adaptive mechanism to inhibit mineral precipitation and eventually calculus formation.
authors.affiliation: Private practice, Erzurum, Turkey.
authors.forename: Gülnihal Emrem
authors.initials: GE
authors.lastname: Doğan
authors.affiliation: University of Ataturk, Faculty of Dentistry, Department of Periodontology, Erzurum, Turkey.
authors.forename: Turgut
authors.initials: T
authors.lastname: Demir
authors.affiliation: University of Ataturk, Faculty of Medicine,Department of Biochemistry, Erzurum, Turkey.
authors.forename: Esra
authors.initials: E
authors.lastname: Laloğlu
authors.affiliation: University of Ataturk, Faculty of Dentistry, Department of Periodontology, Erzurum, Turkey.
authors.forename: Ebru
authors.initials: E
authors.lastname: Sağlam
authors.affiliation: University of Ataturk, Faculty of Medicine,Department of Biochemistry, Erzurum, Turkey.
authors.forename: Hülya
authors.initials: H
authors.lastname: Aksoy
authors.affiliation: Private practice, Erzurum, Turkey.
authors.forename: Abdulkadir
authors.initials: A
authors.lastname: Yildirim
authors.affiliation: Private practice, Erzurum, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Akçay
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D016022:Case-Control Studies; D003728:Dental Calculus / Q000737:chemistry* / Q000235:genetics / Q000503:physiopathology; D003773:Dental Plaque / Q000737:chemistry; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D005883:Gingival Crevicular Fluid / Q000737:chemistry* / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012016:Reference Values; D012463:Saliva / Q000737:chemistry* / Q000502:physiology; D018709:Statistics, Nonparametric; D055815:Young Adult; D060749:alpha-2-HS-Glycoprotein / Q000032:analysis* / Q000235:genetics*
chemical_list: D060749:alpha-2-HS-Glycoprotein