title: ASSOCIATION BETWEEN THE VITREOMACULAR INTERFACE AND OPTICAL COHERENCE TOMOGRAPHY CHARACTERISTICS IN WET AGE-RELATED MACULAR DEGENERATION.
abstract: OBJECTIVE
  To study the effect of the vitreomacular interface on various wet age-related macular degeneration (AMD) characteristics including the size and type of choroidal neovascularization (CNV), choroidal thickness, and activity of the CNV.
  
  
  METHODS
  This was a retrospective observational cross-sectional study. The study included 43 patients (51 eyes) with treatment-naive age-related macular degeneration. Twenty-six patients with wet AMD in one eye and dry AMD in the other eye were included in a paired-eye analysis. Patients underwent optical coherence tomography examination using Heidelberg Spectralis (spectral domain optical coherence tomography) at presentation to determine the type of CNV and the vitreomacular status. In addition, various parameters were measured including the choroidal thickness and horizontal width and vertical height measurements of the CNV.
  
  
  RESULTS
  There was no correlation between the height, width, activity or type of the CNV, and the presence or absence of vitreomacular adhesion. The mean choroidal thickness (using enhanced depth imaging) in cases with vitreomacular adhesion was 272.57 μm compared with 197.32 μm in cases with no vitreomacular adhesion, a statistically significant difference (P = 0.003). In the paired-eye study (21 patients), there was no significant difference between the eyes with wet AMD and dry AMD with regard to vitreomacular status or the choroidal thickness. In a subgroup analysis, patients with Type 1 CNV had a significantly higher percentage of vitreomacular adhesion compared with the other eye with dry AMD (P = 0.034).
  
  
  CONCLUSIONS
  In conclusion, the vitreomacular interface does seem to be associated with an increased choroidal thickness in cases of wet AMD. Furthermore, the association between the vitreomacular interface and wet AMD is more significant for Type 1 CNV.
authors.affiliation: *Department of Ophthalmology, Faculty of Medicine, Alexandria University, Alexandria, Egypt; and †Department of Ophthalmology and Visual Studies, Yale Medical School, European Vitreo-retinal Society (EVRS).
authors.forename: Mohammed
authors.initials: M
authors.lastname: Ashraf
authors.forename: Ahmed
authors.initials: A
authors.lastname: Souka
authors.forename: Ron A
authors.initials: RA
authors.lastname: Adelman
mesh_terms: D000368:Aged; D002829:Choroid / Q000000981:diagnostic imaging / Q000473:pathology; D020256:Choroidal Neovascularization / Q000000981:diagnostic imaging / Q000473:pathology*; D003430:Cross-Sectional Studies; D005260:Female; D057092:Geographic Atrophy / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008266:Macula Lutea / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D000267:Tissue Adhesions / Q000000981:diagnostic imaging / Q000473:pathology; D041623:Tomography, Optical Coherence / Q000379:methods; D014822:Vitreous Body / Q000000981:diagnostic imaging / Q000473:pathology*; D057135:Wet Macular Degeneration / Q000000981:diagnostic imaging / Q000473:pathology*