title: Numerical simulation of mitral valve prolapse considering the effect of left ventricle.
abstract: Heart failure is one of the most important issues that has been investigated in recent research studies. Variations that occur in apparatus of mitral valve, such as chordae tendineaea rupture, can affect the valve function during ventricular contraction and lead to regurgitation from the left ventricle into the left atrium. One method for understanding mitral valve function in such conditions is computational analysis. In this paper, we develop a finite element model of mitral valve prolapse, considering the direct effect of left ventricular motion on blood flow interacting with the mitral valve. Ventricular wall motion is used as a constraint for fluid domain. Arbitrary Lagrangian-Eulerian finite element method formulation is used for numerical solution of transient dynamic equations of the fluid domain. Leaflets' stresses and chordal forces during prolapse are determined and compared to previous healthy results, as well as flow characteristics in the computational domain. Results show considerable increases in the stress magnitudes of interior and posterior leaflets in prolapse condition in comparison with previous healthy studies. In addition, chordae tendineae forces are distributed non-uniformly with higher maximum value here, as a result of other chordae tendineae rupture.
authors.affiliation: Biological Fluid Dynamics Laboratory, Biomedical Egngineering Faculty, Amirkabir University of Technology, Tehran, Iran.
authors.forename: Seyedvahid
authors.initials: S
authors.lastname: Khodaei
authors.affiliation: Biological Fluid Dynamics Laboratory, Biomedical Egngineering Faculty, Amirkabir University of Technology, Tehran, Iran. Electronic address: nasser@aut.ac.ir.
authors.forename: Nasser
authors.initials: N
authors.lastname: Fatouraee
authors.affiliation: Biological Fluid Dynamics Laboratory, Biomedical Egngineering Faculty, Amirkabir University of Technology, Tehran, Iran.
authors.forename: Malikeh
authors.initials: M
authors.lastname: Nabaei
mesh_terms: D006352:Heart Ventricles / Q000503:physiopathology*; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D008945:Mitral Valve Prolapse / Q000503:physiopathology*; D008955:Models, Cardiovascular
keywords: Fluid structure interaction; Hemodynamics; Mitral-valve prolapse; Ventricular motion