title: Refractory rheumatoid vasculitis.
abstract: Systemic rheumatoid vasculitis (SRV) can develop in rheumatoid arthritis of long duration and high disease activity. It most commonly manifests as cutaneous vasculitis and mononeuritis multiplex. This can involve any organ of the body and carries very high mortality. We report a case of a young male who had rheumatoid arthritis for the past 15 years and became refractory to standard drugs and anti-TNF agents. He subsequently developed SRV, which started as mononeuritis multiplex. Disease progressed to result in gangrene of hands and feet despite receiving intravenous cyclophosphamide. Intravenous immunoglobulin and rituximab also could not provide any response. Prolonged ICU stay resulted in critical care neuromyopathy. Central nervous system vasculitis developed even after repeated infusions of intravenous immunoglobulins and at last he died of complications. In this case report, we have presented rare and chronic protracted presentation of rheumatoid vasculitis involving skin, nerves, brain and testis, which was refractory to the recommended therapies.
authors.affiliation: Department of Rheumatology , Fortis Flt Lt Rajan Dhall Hospital , Sector B1 , New Delhi 110070 , India.
authors.forename: Ashok
authors.initials: A
authors.lastname: Kumar
authors.affiliation: Department of Rheumatology , Fortis Flt Lt Rajan Dhall Hospital , Sector B1 , New Delhi 110070 , India.
authors.forename: Anshul
authors.initials: A
authors.lastname: Goel
authors.affiliation: Department of Rheumatology , Fortis Flt Lt Rajan Dhall Hospital , Sector B1 , New Delhi 110070 , India.
authors.forename: Mehul
authors.initials: M
authors.lastname: Lapsiwala
authors.affiliation: Mahajan Imaging Centre , Department of Radiology , Fortis Flt Lt Rajan Dhall Hospital , New Delhi 110070 , India.
authors.forename: Suman
authors.initials: S
authors.lastname: Singhal
keywords: malignant rheumatoid arthritis; rheumatoid arthritis; rheumatoid vasculitis; systemic rheumatoid vasculitis