title: The Effect of Trabeculae Carneae on Left Ventricular Diastolic Compliance: Improvement in Compliance With Trabecular Cutting.
abstract: The role of trabeculae carneae in modulating left ventricular (LV) diastolic compliance remains unclear. The objective of this study was to determine the contribution of trabeculae carneae to the LV diastolic compliance. LV pressure-volume compliance curves were measured in six human heart explants from patients with LV hypertrophy at baseline and following trabecular cutting. The effect of trabecular cutting was also analyzed with finite-element model (FEM) simulations. Our results demonstrated that LV compliance improved after trabecular cutting (p < 0.001). Finite-element simulations further demonstrated that stiffer trabeculae reduce LV compliance further, and that the presence of trabeculae reduced the wall stress in the apex. In conclusion, we demonstrate that integrity of the LV and trabeculae is important to maintain LV stiffness and loss in trabeculae leads to more LV compliance.
authors.affiliation: Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229;Department of Veterans Affairs, South Texas Veterans Health Care System, San Antonio, TX 78229.
authors.forename: David L
authors.initials: DL
authors.lastname: Halaney
authors.affiliation: Department of Mechanical Engineering, University of Texas at San Antonio, San Antonio, TX 78249.
authors.forename: Arnav
authors.initials: A
authors.lastname: Sanyal
authors.affiliation: Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229.
authors.forename: Navid A
authors.initials: NA
authors.lastname: Nafissi
authors.affiliation: Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229;Department of Veterans Affairs, South Texas Veterans Health Care System, San Antonio, TX 78229.
authors.forename: Daniel
authors.initials: D
authors.lastname: Escobedo
authors.affiliation: Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229.
authors.forename: Martin
authors.initials: M
authors.lastname: Goros
authors.affiliation: Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229.
authors.forename: Joel
authors.initials: J
authors.lastname: Michalek
authors.affiliation: Department of Anatomy, University of Environmental and Applied Sciences U.D.C.A., Bogotá, Cundinamarca, Colombia.
authors.forename: Pedro J
authors.initials: PJ
authors.lastname: Acevedo
authors.affiliation: Department of Anatomy, Faculty of Veterinary Medicine, University of the Republic, Montevideo 11200, Uruguay.
authors.forename: William
authors.initials: W
authors.lastname: Pérez
authors.affiliation: Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229.
authors.forename: G
authors.initials: G
authors.lastname: Patricia Escobar
authors.affiliation: Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229;Department of Veterans Affairs, South Texas Veterans Health Care System, San Antonio, TX 78229 e-mail: feldmanm@uthscsa.edu.
authors.forename: Marc D
authors.initials: MD
authors.lastname: Feldman
authors.affiliation: Fellow ASME Department of Mechanical Engineering, University of Texas at San Antonio, San Antonio, TX 78249.
authors.forename: Hai-Chao
authors.initials: HC
authors.lastname: Han
mesh_terms: D000368:Aged; D003971:Diastole / Q000502:physiology*; D005260:Female; D006352:Heart Ventricles; D006801:Humans; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D009206:Myocardium / Q000378:metabolism*; D013314:Stress, Mechanical; D016277:Ventricular Function, Left