title: In silico Analysis of Toxins of Staphylococcus aureus for Validating Putative Drug Targets.
abstract: Toxins are one among the numerous virulence factors produced by the bacteria. These are powerful poisonous substances enabling the bacteria to encounter the defense mechanism of human body. The pathogenic system of Staphylococcus aureus is evolved with various exotoxins that cause detrimental effects on human immune system. Four toxins namely enterotoxin A, exfoliative toxin A, TSST-1 and γ-hemolysin were downloaded from Uniprot database and were analyzed to understand the nature of the toxins and for drug target validation. The results inferred that the toxins were found to interact with many protein partners and no homologous sequences for human proteome were found, and based on similarity search in Drugbank, the targets were identified as novel drug targets.
authors.affiliation: Department of Integrative Biology, VIT University, Vellore-632014, Tamil Nadu, India.
authors.forename: Ramadevi
authors.initials: R
authors.lastname: Mohana
authors.affiliation: Department of Integrative Biology, VIT University, Vellore-632014, Tamil Nadu, India.
authors.forename: Subhashree
authors.initials: S
authors.lastname: Venugopal
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000737:chemistry / Q000378:metabolism; D001427:Bacterial Toxins / Q000737:chemistry* / Q000378:metabolism*; D003198:Computer Simulation; D004768:Enterotoxins / Q000737:chemistry / Q000378:metabolism; D005083:Exfoliatins / Q000737:chemistry / Q000378:metabolism; D006460:Hemolysin Proteins / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000382:microbiology; D013211:Staphylococcus aureus / Q000737:chemistry* / Q000187:drug effects / Q000472:pathogenicity; D018089:Superantigens / Q000737:chemistry / Q000378:metabolism; D037521:Virulence Factors / Q000737:chemistry / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D001427:Bacterial Toxins; D004768:Enterotoxins; D005083:Exfoliatins; D006460:Hemolysin Proteins; D018089:Superantigens; D037521:Virulence Factors; C030107:enterotoxin F, Staphylococcal; C037956:gamma-hemolysin, Staphylococcus aureus; C026066:enterotoxin A, Staphylococcal
keywords: BLAST; Staphylococcus aureus toxins; drug target validation; in silico analysis; interactome
  analysis