title: Weight loss and carotid intima-media thickness-a meta-analysis.
abstract: Obesity is a risk factor for clinical cardiovascular disease, putatively via increased burden of atherosclerosis. It remains contentious as to whether weight loss in people with obesity is accompanied by a reduction in intima-media thickness, a noninvasive marker of subclinical atherosclerosis, consistent with a lowering of risk of cardiovascular events.
  
  
  
  A systematic literature search was performed to identify all surgical and nonsurgical weight loss interventions that reported intima-media thickness. A meta-analysis was undertaken to obtain pooled estimates for change in intima-media thickness.
  
  
  
  From the 3,197 articles screened, 9 studies were included in the meta-analysis, with a total of 393 participants who lost an average of 16 kg (95% CI 9.4-22.5) of body weight over an average follow-up of 20 months. The pooled mean change in carotid intima-media thickness was -0.03 mm (95% CI -0.05 to -0.01), which was similar between surgical and nonsurgical interventions.
  
  
  
  In people with obesity, weight loss was associated with a reduction in carotid intima-media thickness, consistent with a lowering in risk of cardiovascular events.
authors.affiliation: The Boden Institute of Obesity, Nutrition, Exercise & Eating Disorders, University of Sydney, Sydney, New South Wales, Australia.|Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.|Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia.
authors.forename: Michael R
authors.identifier: 0000-0003-2793-2388
authors.initials: MR
authors.lastname: Skilton
authors.affiliation: The Boden Institute of Obesity, Nutrition, Exercise & Eating Disorders, University of Sydney, Sydney, New South Wales, Australia.|Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.
authors.forename: Si Qin
authors.initials: SQ
authors.lastname: Yeo
authors.affiliation: The Boden Institute of Obesity, Nutrition, Exercise & Eating Disorders, University of Sydney, Sydney, New South Wales, Australia.|Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.
authors.forename: Jia Yi Anna
authors.initials: JY
authors.lastname: Ne
authors.affiliation: Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.
authors.forename: David S
authors.initials: DS
authors.lastname: Celermajer
authors.affiliation: The Boden Institute of Obesity, Nutrition, Exercise & Eating Disorders, University of Sydney, Sydney, New South Wales, Australia.|Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia.
authors.forename: Ian D
authors.initials: ID
authors.lastname: Caterson
authors.affiliation: The Boden Institute of Obesity, Nutrition, Exercise & Eating Disorders, University of Sydney, Sydney, New South Wales, Australia.|Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia.|School of Public Health, Curtin University, Perth, Western Australia, Australia.
authors.forename: Crystal Man Ying
authors.initials: CM
authors.lastname: Lee
mesh_terms: D050197:Atherosclerosis / Q000000981:diagnostic imaging / Q000503:physiopathology*; D059168:Carotid Intima-Media Thickness; D006801:Humans; D009765:Obesity / Q000000981:diagnostic imaging / Q000503:physiopathology*; D012307:Risk Factors; D015431:Weight Loss / Q000502:physiology*