title: [Analysis of Indicators Related with Cell Proliferation and Apoptosis in the Patients with B Cell Non-Hodgkin's Lymphoma].
abstract: OBJECTIVE
  To analyze the indicators related with cell proliferation and apoptosis in patients with B cell non-Hodgkin's lymphoma(B-NHL).
  
  
  METHODS
  Seventy-two cases of B-NHL and 50 cases of reactive hyperplasia of lymph nodes were entrolled in the experimental group and control group respectively. The expression levels of proliferating cell nuclear antigen(PCNA), X-linked inhibitor of apoptosis(XIAP) and B cell lymphoma leukemia-2(BCL-2) in paraffin-embedded tissue samples of 2 groups were detected by immuno-histochemistry staining, and their ralationship with pathologic factors was analyzed.
  
  
  RESULTS
  The positive cell rates of PCNA, XIAP and BCL-2 in experiment group were significantly higher than those in control group (P<0.05); the positive cell rate of PCNA in B-NHL patients at III-IV stage was higher than that in B-NHL patients at I-II stage(P<0.05), however, the positive cell rates of XIAP and BCL-2 in B-NHL patients with different pathologic factors were not significantly different(P>0.05). The progression-free survival(PES) time in PCNA low positive expression group was longer than that in PCNA high positive expression group(P<0.05), but the PFS time between B-NHL patients with XIAP positive and negative expression was not significantly different(P>0.05); the PFS time also was not significantly different between B-NHL patients with BCL-2 positive and negative expression(P>0.05).
  
  
  CONCLUSIONS
  All the PCNA, XIAP and BCL-2 participate in the pathngenesis of B-NHL, among them the positive level of PCNA obviously influences the clinical staging of B-NHL.
authors.affiliation: Department of Hematology,Xinxiang Municipal Centreal Hospital, Xinxiang 453000, Henan Province, China. E-mail:yinjunjiebest@163.com.
authors.forename: Jue-Jie
authors.initials: JJ
authors.lastname: Yin
authors.affiliation: Department of Hematology,Xinxiang Municipal Centreal Hospital, Xinxiang 453000, Henan Province, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Liang
authors.affiliation: Second Department of Oncology, Xinxiang Municipal Centreal Hospital, Xinxiang 453000, Henan Province, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Department of Hematology,Xinxiang Municipal Centreal Hospital, Xinxiang 453000, Henan Province, China.
authors.forename: Xin-Rong
authors.initials: XR
authors.lastname: Zhan
mesh_terms: D017209:Apoptosis; D001402:B-Lymphocytes; D049109:Cell Proliferation; D018572:Disease-Free Survival; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes; D008228:Lymphoma, Non-Hodgkin; D018809:Proliferating Cell Nuclear Antigen
chemical_list: D018809:Proliferating Cell Nuclear Antigen