title: Functional Nanoarchitectures For Enhanced Drug Eluting Stents.
abstract: Different strategies have been investigated to allow for optimum duration and conditions for endothelium healing through the enhancement of coronary stents. In this study, a nanoarchitectured system is proposed as a surface modification for drug eluting stents. Highly oriented nanotubes were vertically grown on the surface of a new Ni-free biocompatible Ti-based alloy, as a potential material for self-expandable stents. The fabricated nanotubes were self-grown from the potential stent substrate, which are also proposed to enhance endothelial proliferation while acting as drug reservoir to hinder Vascular Smooth Muscle Cells (VSMC) proliferation. Two morphologies were synthesized to investigate the effect of structure homogeneity on the intended application. The material was characterized by field-emission scanning electron microscope (FESEM), X-ray diffraction (XRD), Raman spectroscopy, energy dispersive X-ray spectroscopy (EDX), and X-ray photoelectron spectroscopy (XPS). Nanoindentation technique was used to study the mechanical properties of the fabricated material. Cytotoxicity and proliferation studies were performed and compared for the two fabricated nanoarchitectures, versus smooth untextured samples, using in-vitro cultured endothelial cells. Finally, the drug loading capacity was experimentally studied and further supported by computational modeling of the release profile.
authors.affiliation: Energy Materials Laboratory (EML), School of Sciences and Engineering, The American University in Cairo, New Cairo 11835, Egypt.
authors.forename: Yomna E
authors.initials: YE
authors.lastname: Saleh
authors.affiliation: Department of Materials Science and Engineering, Egypt-Japan University for Science and Technology, New Borg El-Arab 21934, Alexandria, Egypt.
authors.forename: Mohamed A
authors.initials: MA
authors.lastname: Gepreel
authors.affiliation: Energy Materials Laboratory (EML), School of Sciences and Engineering, The American University in Cairo, New Cairo 11835, Egypt.
authors.forename: Nageh K
authors.initials: NK
authors.lastname: Allam
mesh_terms: D016923:Cell Death; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival; D016503:Drug Delivery Systems; D065546:Drug Liberation; D054855:Drug-Eluting Stents; D004566:Electrodes; D004573:Electrolytes / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D043942:Nanotubes / Q000737:chemistry / Q000648:ultrastructure; D009556:Niobium / Q000737:chemistry; D010087:Oxides / Q000737:chemistry; D056951:Photoelectron Spectroscopy; D013059:Spectrum Analysis, Raman; D013635:Tantalum / Q000737:chemistry; D013696:Temperature; D014025:Titanium / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D004573:Electrolytes; D010087:Oxides; D009556:Niobium; D013635:Tantalum; D014025:Titanium