title: Vagus nerve stimulation for genetic epilepsy with febrile seizures plus (GEFS+) accompanying seizures with impaired consciousness.
abstract: Genetic epilepsy with febrile seizures plus (GEFS+) is characterized by childhood-onset epilepsy syndrome. It involves febrile seizures and a variety of afebrile epileptic seizure types within the same pedigree with autosomal-dominant inheritance. Approximately 10% of individuals with GEFS+harbor SCN1A, a gene mutation in one of the voltage-gated sodium channel subunits. Considerably less common are focal epilepsies including complex partial seizures. We report vagus nerve stimulation (VNS) in a 6-year-old girl with GEFS+who exhibited refractory generalized tonic-clonic seizures and complex partial seizures.
authors.affiliation: Department of Neurosurgery, Graduate School of Medical and Dental Science, Kagoshima University, Kagoshima, Japan.
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Hanaya
authors.affiliation: Department of Neurosurgery, Medical Faculty of Diponegoro University, Semarang, Indonesia.
authors.forename: Fajar H
authors.initials: FH
authors.lastname: Niantiarno
authors.affiliation: Department of Neurosurgery, Graduate School of Medical and Dental Science, Kagoshima University, Kagoshima, Japan.
authors.forename: Yumi
authors.initials: Y
authors.lastname: Kashida
authors.affiliation: Department of Neurosurgery, Graduate School of Medical and Dental Science, Kagoshima University, Kagoshima, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hosoyama
authors.affiliation: Department of Pediatrics, Graduate School of Medical and Dental Science, Kagoshima University, Kagoshima, Japan.
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Maruyama
authors.affiliation: Fujimoto General Hospital, Miyakonojo, Japan.
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Otsubo
authors.affiliation: Department of Pediatrics, Saiseikai Sendai Hospital, Satsuma-Sendai, Japan.
authors.forename: Kazumi
authors.initials: K
authors.lastname: Tanaka
authors.affiliation: Department of Pediatrics, Fukuoka University School of Medicine, Fukuoka, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ishii
authors.affiliation: Department of Pediatrics, Fukuoka University School of Medicine, Fukuoka, Japan.
authors.forename: Shinichi
authors.initials: S
authors.lastname: Hirose
authors.affiliation: Department of Neurosurgery, Graduate School of Medical and Dental Science, Kagoshima University, Kagoshima, Japan.
authors.forename: Kazunori
authors.initials: K
authors.lastname: Arita
keywords: Complex partial seizure; Genetic epilepsy with febrile seizure plus (GEFS+); Vagus nerve stimulation (VNS)