title: The acute effects of thymoquinone on acute peripheral nerve injury: an experimental study.
abstract: BACKGROUND
  The purpose of this study was to evaluate the acute effects of thymoquinone (TQ) on acute nerve injury.
  
  
  METHODS
  A rat model of crush injury of the sciatic nerve was used. Animals were divided into 3 groups: control, trauma, and TQ treatment groups (n=6 per group). Seven days after injury, sciatic nerve specimens were obtained from the site of the injury and analyzed histologically and stereologically. Axon diameter, myelin thickness, and axon density were measured.
  
  
  RESULTS
  There were no significant differences in axon diameter, myelin thickness, or axon density among groups.
  
  
  CONCLUSIONS
  TQ has no acute therapeutic effect on acute nerve injury.
authors.affiliation: Department of Neurosurgery, Yüzüncü Yıl University Faculty of Medicine, Van-Turkey. dr-ismailgulsen@hotmail.com.
authors.forename: İsmail
authors.initials: İ
authors.lastname: Gülşen
authors.forename: Hakan
authors.initials: H
authors.lastname: Ak
authors.forename: Mikail
authors.initials: M
authors.lastname: Kara
authors.forename: Abdulsemat
authors.initials: A
authors.lastname: Gökalp
authors.forename: Veysel
authors.initials: V
authors.lastname: Akyol
authors.forename: Ömer Faruk
authors.initials: ÖF
authors.lastname: Koçak
authors.forename: Murat Çetin
authors.initials: MÇ
authors.lastname: Rağbetli
mesh_terms: D000818:Animals; D016227:Benzoquinones / Q000008:administration & dosage / Q000627:therapeutic use*; D004195:Disease Models, Animal; D005260:Female; D009416:Nerve Regeneration; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D059348:Peripheral Nerve Injuries / Q000517:prevention & control*; D011897:Random Allocation; D051381:Rats; D012584:Sciatic Nerve / Q000293:injuries*
chemical_list: D016227:Benzoquinones; D018696:Neuroprotective Agents; C003466:thymoquinone