title: Body Composition Trajectories From Infancy to Preschool in Children Born Premature Versus Full-term.
abstract: The aim of the study was to longitudinally characterize infancy to preschool body composition trajectories and the association of early fat and fat-free mass gains with preschool age body composition in children born premature versus full-term.
  
  
  
  A cohort of appropriate-for-gestational age preterm (n = 20) and term (n = 51) infants were followed at 3 visits: "neonatal" visit 1 at 2 weeks of age for term and near term corrected age for preterm; "infancy" visit 2 at 3 to 4 months (preterm corrected age); "preschool" visit 3 at 4 years. Body composition via air displacement plethysmography and anthropometrics were measured at all visits. Tracking of infancy weight and body composition with preschool measurements was tested using Pearson partial correlation coefficients. Associations between serial body composition measurements were assessed using multiple linear regression.
  
  
  
  Early differences in body composition between premature (mean gestational age 31.9 weeks, mean birth weight 1843 g) and full-term (mean gestational age 39.8 weeks) infants were not present at preschool age. Visit 1 body composition was not correlated with preschool measurements in the preterm infants. Visit 2 measurements were correlated with preschool measures. Fat-free mass accretion from visit 1 to visit 2 was positively associated with preschool lean mass (β = 0.038, P = 0.049) in preterm children, whereas fat accretion was not associated with preschool body composition.
  
  
  
  Children born prematurely and full-term have similar body composition at preschool age. For preterms infancy fat-free mass gains, and not adiposity gains, are positively associated with preschool fat-free mass; this may be associated with lower risk of later obesity and adverse metabolic outcomes.
authors.affiliation: *Division of Neonatology, Department of Pediatrics †Biostatistical Design and Analysis Center ‡Medical School §Epidemiology and Community Health, University of Minnesota, Minneapolis, MN.
authors.forename: Johannah M
authors.initials: JM
authors.lastname: Scheurer
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Heather L
authors.initials: HL
authors.lastname: Gray
authors.forename: Katherine
authors.initials: K
authors.lastname: Weir
authors.forename: Ellen W
authors.initials: EW
authors.lastname: Demerath
authors.forename: Sara E
authors.initials: SE
authors.lastname: Ramel
mesh_terms: D050154:Adiposity / Q000502:physiology; D001823:Body Composition; D002657:Child Development / Q000502:physiology*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D016014:Linear Models; D008137:Longitudinal Studies; D008297:Male; D010991:Plethysmography