title: Review of allogeneic hematopoietic stem cell transplantation with reduced intensity conditioning in solid tumors excluding breast cancer.
abstract: Solid tumors in adults constitute a heterogeneous group of malignancy originating from various organ systems. Solid tumors are not completely curable by chemotherapy, even though some subgroups are very chemo-sensitive. Recently, oncologists have focused on the use of allogeneic hematopoietic stem cell transplantation (allo-HSCT) with reduced intensity conditioning (RIC) for the treatment of some refractory solid tumors. After the demonstration of allogeneic graft-versus-leukemia effect in patients with hematological malignancies who received allo-HSCT, investigators evaluated this effect in patients with refractory metastatic solid tumors. According to data from experimental animal models and preliminary clinical trials, a graft-versus-tumor (GvT) effect may also be observed in the treatment of some solid tumors (e.g., renal cell cancer, colorectal cancer,etc.) after allo-HSCT with RIC. The use of RIC regimens offers an opportunity of achieving full-donor engraftment with GvT effect, as well as, a reduced transplant-related mortality. Current literature suggests that allo-HSCT with RIC might become a choice for elderly and medically fragile patients with refractory metastatic solid tumors.
authors.affiliation: Nuri Karadurmus, Bilgin Bahadir Basgoz, Department of Medical Oncology, Gulhane Military Medical Academy, Etlik, 06018 Ankara, Turkey.
authors.forename: Nuri
authors.initials: N
authors.lastname: Karadurmus
authors.affiliation: Nuri Karadurmus, Bilgin Bahadir Basgoz, Department of Medical Oncology, Gulhane Military Medical Academy, Etlik, 06018 Ankara, Turkey.
authors.forename: Ugur
authors.initials: U
authors.lastname: Sahin
authors.affiliation: Nuri Karadurmus, Bilgin Bahadir Basgoz, Department of Medical Oncology, Gulhane Military Medical Academy, Etlik, 06018 Ankara, Turkey.
authors.forename: Bilgin Bahadir
authors.initials: BB
authors.lastname: Basgoz
authors.affiliation: Nuri Karadurmus, Bilgin Bahadir Basgoz, Department of Medical Oncology, Gulhane Military Medical Academy, Etlik, 06018 Ankara, Turkey.
authors.forename: Fikret
authors.initials: F
authors.lastname: Arpaci
authors.affiliation: Nuri Karadurmus, Bilgin Bahadir Basgoz, Department of Medical Oncology, Gulhane Military Medical Academy, Etlik, 06018 Ankara, Turkey.
authors.forename: Taner
authors.initials: T
authors.lastname: Demirer
keywords: Allogeneic hematopoietic stem cell transplantation; Colorectal cancer; Ovarian cancer; Renal cell carcinoma; Sarcoma