title: Cancer incidence among capacitor manufacturing workers exposed to polychlorinated biphenyls.
abstract: BACKGROUND
  We evaluated cancer incidence in a cohort of polychlorinated biphenyl (PCB) exposed workers.
  
  
  METHODS
  Incident cancers, identified using state registries, were compared to those in a national population using standardized incidence ratios. Trends in prostate cancer incidence with cumulative PCB exposure were evaluated using standardized rate ratios and Cox regression models. For selected sites, cumulative PCB exposure was compared between aggressive (fatal/distant stage) and localized/regional cancers.
  
  
  RESULTS
  We identified 3,371 invasive first primary cancer diagnoses among 21,317 eligible workers through 2007. Overall relative incidence was reduced. Elevations were only observed for respiratory cancers and among women, urinary organ cancers. Among men, prostate cancer incidence was reduced and not associated with cumulative PCB exposure although median exposures were significantly higher for aggressive compared to localized/regional prostate cancers.
  
  
  CONCLUSIONS
  Previously observed associations between cumulative PCB exposure and prostate cancer mortality were not confirmed in this analysis; prostate cancer stage at diagnosis may explain the discrepancy. Am. J. Ind. Med. 60:198-207, 2017. Published 2016. This article is a U.S. Government work and is in the public domain in the USA.
authors.affiliation: National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations, and Field Studies, Cincinnati, Ohio.
authors.forename: Avima M
authors.initials: AM
authors.lastname: Ruder
authors.affiliation: National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations, and Field Studies, Cincinnati, Ohio.|CACI, Inc., Cincinnati, Ohio.
authors.forename: Misty J
authors.initials: MJ
authors.lastname: Hein
authors.affiliation: Institute for Work and Health (IST), Epalinges-Lausanne, Switzerland.
authors.forename: Nancy B
authors.initials: NB
authors.lastname: Hopf
authors.affiliation: National Institute for Occupational Safety and Health, Division of Applied Research and Technology, Cincinnati, Ohio.
authors.forename: Martha A
authors.initials: MA
authors.lastname: Waters
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology*; D009784:Occupational Diseases / Q000453:epidemiology*; D016273:Occupational Exposure / Q000009:adverse effects; D011078:Polychlorinated Biphenyls / Q000633:toxicity*; D012042:Registries; D014481:United States / Q000453:epidemiology; D055815:Young Adult
chemical_list: D011078:Polychlorinated Biphenyls
keywords: cancer incidence; occupational exposure; polychlorinated biphenyls; prostate neoplasms