title: Recent progress in translational research on neurovascular and neurodegenerative disorders.
abstract: The already established and widely used intravenous application of recombinant tissue plasminogen activator as a re-opening strategy for acute vessel occlusion in ischemic stroke was recently added by mechanical thrombectomy, representing a fundamental progress in evidence-based medicine to improve the patient's outcome. This has been paralleled by a swift increase in our understanding of pathomechanisms underlying many neurovascular diseases and most prevalent forms of dementia. Taken together, these current advances offer the potential to overcome almost two decades of marginally successful translational research on stroke and dementia, thereby spurring the entire field of translational neuroscience. Moreover, they may also pave the way for the renaissance of classical neuroprotective paradigms.This review reports and summarizes some of the most interesting and promising recent achievements in neurovascular and dementia research. It highlights sessions from the 9th International Symposium on Neuroprotection and Neurorepair that have been discussed from April 19th to 22nd in Leipzig, Germany. To acknowledge the emerging culture of interdisciplinary collaboration and research, special emphasis is given on translational stories ranging from fundamental research on neurode- and -regeneration to late stage translational or early stage clinical investigations.
authors.affiliation: Department of Drug Design and Target Validation, Fraunhofer Institute for Cell Therapy and Immunology (IZI-MWT), Halle/Saale, Germany.
authors.forename: Hans-Ulrich
authors.initials: HU
authors.lastname: Demuth
authors.affiliation: Biomedical MR Imaging and Spectroscopy Group, Center for Image Sciences, University Medical Center Utrecht, The Netherlands.
authors.forename: Rick M
authors.initials: RM
authors.lastname: Dijkhuizen
authors.affiliation: School of Life Sciences, University of Nottingham, Nottingham, UK.
authors.forename: Tracy D
authors.initials: TD
authors.lastname: Farr
authors.affiliation: Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
authors.forename: Mathias
authors.initials: M
authors.lastname: Gelderblom
authors.affiliation: Centre for Neuroregeneration, University of Edinburgh, Edinburgh, UK.
authors.forename: Karen
authors.initials: K
authors.lastname: Horsburgh
authors.affiliation: Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
authors.forename: Costantino
authors.initials: C
authors.lastname: Iadecola
authors.affiliation: University of Newcastle, Hunter Medical Research Institute and Hunter New England Local Health District, Newcastle, Australia.
authors.forename: Damian D
authors.initials: DD
authors.lastname: Mcleod
authors.affiliation: Department of Neurology, University of Leipzig, Leipzig, Germany.
authors.forename: Dominik
authors.initials: D
authors.lastname: Michalski
authors.affiliation: Department of Psychiatry, University of British Columbia, Vancouver, Canada.
authors.forename: Tim H
authors.initials: TH
authors.lastname: Murphy
authors.affiliation: Atherothrombosis Laboratory, Centre for Applied Medical Research, University of Navarra, Pamplona, Spain.
authors.forename: Josune
authors.initials: J
authors.lastname: Orbe
authors.affiliation: Biomedical MR Imaging and Spectroscopy Group, Center for Image Sciences, University Medical Center Utrecht, The Netherlands.|Department of Pediatric Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: Willem M
authors.initials: WM
authors.lastname: Otte
authors.affiliation: German Center for Neurodegenerative Diseases, Bonn, Germany.
authors.forename: Gabor C
authors.initials: GC
authors.lastname: Petzold
authors.affiliation: Institute for Stroke and Dementia Research (ISD), University of Munich Medical Center; Munich Cluster of Systems Neurology (Synergy), LMU Munich, Germany.
authors.forename: Nikolaus
authors.initials: N
authors.lastname: Plesnila
authors.affiliation: Institute for Neurobiochemistry, University of Magdeburg, Magdeburg, Germany.
authors.forename: Georg
authors.initials: G
authors.lastname: Reiser
authors.affiliation: Neuropharmacology Lab, Leibniz Institute for Neurobiology, Magdeburg, Germany.
authors.forename: Klaus G
authors.initials: KG
authors.lastname: Reymann
authors.affiliation: Department of Neurology, University Hospital of Cologne, Cologne, Germany.
authors.forename: Maria A
authors.initials: MA
authors.lastname: Rueger
authors.affiliation: Department of Neurology, University of Leipzig, Leipzig, Germany.
authors.forename: Dorothee
authors.initials: D
authors.lastname: Saur
authors.affiliation: Department of Neurology, UTHealth Medical School, Houston, TX, USA.
authors.forename: Sean I
authors.initials: SI
authors.lastname: Savitz
authors.affiliation: Department of Drug Design and Target Validation, Fraunhofer Institute for Cell Therapy and Immunology (IZI-MWT), Halle/Saale, Germany.
authors.forename: Stephan
authors.initials: S
authors.lastname: Schilling
authors.affiliation: University of Newcastle, Hunter Medical Research Institute and Hunter New England Local Health District, Newcastle, Australia.
authors.forename: Neil J
authors.initials: NJ
authors.lastname: Spratt
authors.affiliation: Adelaide Medical School and Adelaide Centre for Neuroscience Research, The University of Adelaide, Adelaide, Australia.
authors.forename: Renée J
authors.initials: RJ
authors.lastname: Turner
authors.affiliation: Deptartment of Neurological Surgery, University of Wisconsin and William S. Middleton VA Hospital, Madison, WI, USA.
authors.forename: Raghu
authors.initials: R
authors.lastname: Vemuganti
authors.affiliation: Cell Biology and Clinical Research Department, Medical Center, Université Caen-Normandie, GIP Cyceron; Inserm, Inserm UMR-S U919, Serine Proteases and Pathophysiology of the neurovascular Unit, Caen, France.
authors.forename: Denis
authors.initials: D
authors.lastname: Vivien
authors.affiliation: Department of Neurology, Emory University, Atlanta, GA, USA.
authors.forename: Manuel
authors.initials: M
authors.lastname: Yepes
authors.affiliation: Department of Neurology and Neuroscience, The Burke Medical Research Institute, Weill Medical College of Cornell University, White Plains, NY, USA.
authors.forename: Marietta
authors.initials: M
authors.lastname: Zille
authors.affiliation: Department of Medical Cell Technology, Fraunhofer Research Institution for Marine Biotechnology; Institute for Medical and Marine Biotechnology, University of Lübeck, Lübeck, Germany.
authors.forename: Johannes
authors.initials: J
authors.lastname: Boltze
mesh_terms: D000818:Animals; D002561:Cerebrovascular Disorders / Q000175:diagnosis* / Q000628:therapy*; D006801:Humans; D019636:Neurodegenerative Diseases / Q000175:diagnosis* / Q000628:therapy*; D057170:Translational Research, Biomedical
keywords: Alzheimer’s disease; brain; cerebral ischemia; cerebral small vessel disease; dementia; experimental therapy; hemorrhage; in vivo imaging; neuroimmunology; neuroprotection; neurorepair; sex differences; stroke; translational research; vascular cognitive impairment