title: Unbalanced Oxidant-Antioxidant Status: A Potential Therapeutic Target for Coronary Chronic Total Occlusion in Very Old Patients.
abstract: Unbalanced oxidant and antioxidant status played an important role in myocardial infarction. The present study was a clinical trial combined preclinically with targeted agent against cardiovascular injuries and ischemia in vivo model. We tried to confirm the association of unbalanced oxidant and antioxidant status with coronary chronic total occlusion (CTO) in 399 very old patients (80~89 years) and investigated the potential therapeutic value of purified polysaccharide from endothelium corneum gigeriae galli (PECGGp). We analyzed levels of circulating superoxide dismutase 3 (SOD3), nitric oxide (NO), endothelial nitric oxide synthase (eNOS), and malondialdehyde (MDA) in very old patients with coronary CTO. Levels of SOD3, NO, eNOS, and MDA in the cardiac tissue were measured in myocardial infarction rats. Levels of SOD3, eNOS, and NO were lowered (p< 0.001) and levels of MDA were increased (p< 0.001). PECGGp treatment increased levels of SOD3, eNOS, and NO (p< 0.01) in cardiac tissue, while decreasing levels of MDA (p< 0.01). PECGGp may suppress unbalanced oxidant and antioxidant status in infarcted myocardium by inhibiting levels of MDA and elevating NO, eNOS, and SOD3 levels. PECGGp could be considered as a potential therapeutic agent for coronary CTO in very old patients.
authors.affiliation: Department of Geriatrics, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, Jiangsu 223002, China.
authors.forename: Xia
authors.identifier: 0000-0002-5178-8059
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Geriatrics, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, Jiangsu 223002, China.
authors.forename: Youdong
authors.identifier: 0000-0003-3584-0651
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Department of Geriatrics, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, Jiangsu 223002, China.
authors.forename: Fenglin
authors.identifier: 0000-0002-8984-7931
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Department of Geriatrics, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, Jiangsu 223002, China.
authors.forename: Ying
authors.identifier: 0000-0002-3707-1414
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Geriatrics, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, Jiangsu 223002, China.
authors.forename: Hualan
authors.identifier: 0000-0001-5044-0512
authors.initials: H
authors.lastname: Zhou
authors.affiliation: Department of Geriatrics, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, Jiangsu 223002, China.
authors.forename: Dianxuan
authors.identifier: 0000-0003-0592-8134
authors.initials: D
authors.lastname: Guo
authors.affiliation: Department of Geriatrics, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, Jiangsu 223002, China.
authors.forename: Qingna
authors.identifier: 0000-0001-9976-4163
authors.initials: Q
authors.lastname: Zhao
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D002908:Chronic Disease; D054059:Coronary Occlusion / Q000097:blood / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D058990:Molecular Targeted Therapy; D009203:Myocardial Infarction / Q000097:blood / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology; D009569:Nitric Oxide / Q000097:blood; D052247:Nitric Oxide Synthase Type II / Q000097:blood; D016877:Oxidants / Q000378:metabolism*; D011134:Polysaccharides; D051381:Rats; D013318:Stroke Volume; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D000975:Antioxidants; D016877:Oxidants; D011134:Polysaccharides; D009569:Nitric Oxide; D008315:Malondialdehyde; D052247:Nitric Oxide Synthase Type II; C441642:SOD3 protein, human; D013482:Superoxide Dismutase