title: The First Experience ofEx-VivoLung Perfusion (EVLP) in Iran: An Effective Method to Increase Suitable Lung for Transplantation.
abstract: BACKGROUND
  Although lung transplantation is a well-accepted treatment for end-stage lung diseases patients, only 15%-20% of the brain-dead donors' lungs are usable for transplantation. This results in high mortality of candidates on waiting lists.Ex-vivolung perfusion (EVLP) is a novel method for better evaluation of a potential lung for transplantation.
  
  
  OBJECTIVE
  To report the first experience of EVLP in Iran.
  
  
  METHODS
  The study included a pig in Vienna Medical University, Vienna, Austria, and 4 humans in Masih Daneshvari Hospital, Tehran, Iran. All brain-dead donors from 2013 to 2015 in Tehran were evaluated for EVLP. Donors without signs of severe chest trauma or pneumonia, with poor oxygenation were included.
  
  
  RESULTS
  An increasing trend in difference between the pulmonary arterial pO2and left atrial pO2, an increasing pattern in dynamic lung compliance, and a decreasing trend in the pulmonary vascular resistance, were observed.
  
  
  CONCLUSIONS
  The initial experience of EVLP in Iran was successful in terms of important/critical parameters. The results emphasize on some important considerations such as precisely following standard lung harvesting and monitoring temperature and pressure. EVLP technique may not be a cost-effective option for low-income countries at first glance. However, because this is the only therapeutic treatment for end-stage lung disease, it is advisable to continue working on this method to find alternatives with lesser costs.
authors.affiliation: Lung Transplant Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: S
authors.initials: S
authors.lastname: Shafaghi
authors.affiliation: Lung Transplant Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Organ Transplantation Office, Ministry of Health and Medical Education, Iran.
authors.forename: K
authors.initials: K
authors.lastname: Najafizadeh
authors.affiliation: Lung Transplant Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: K
authors.initials: K
authors.lastname: Sheikhy
authors.affiliation: Lung Transplant Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Z
authors.initials: Z
authors.lastname: Ansari Aval
authors.affiliation: Tracheal Diseases Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: B
authors.initials: B
authors.lastname: Farzanegan
authors.affiliation: Lung Transplant Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Y
authors.initials: Y
authors.lastname: Mafhoomi
authors.affiliation: Lung Transplant Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Z
authors.initials: Z
authors.lastname: Faghih Abdollahi
authors.affiliation: Tobacco Prevention and Control Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: H
authors.initials: H
authors.lastname: Emami
authors.affiliation: Cell and Molecular Biology Group, Airways Disease Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, Dovehouse Street, London, United Kingdom; Chronic Respiratory Diseases Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: E
authors.initials: E
authors.lastname: Mortaz
authors.affiliation: Lung Transplant Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Porabdollah
authors.affiliation: Tracheal Diseases Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: A
authors.initials: A
authors.lastname: Jahangiri Fard
authors.affiliation: Lung Transplant Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Nikobayan Safaei
authors.affiliation: Department of Thoracic Surgery, Medical University of Vienna, Vienna, Austria.
authors.forename: A
authors.initials: A
authors.lastname: Slama
authors.affiliation: Department of Thoracic Surgery, Medical University of Vienna, Vienna, Austria.
authors.forename: C
authors.initials: C
authors.lastname: Aigner
authors.affiliation: Minimally Invasive Surgery Research Center (MISRC), Iran University of Medical Sciences, Tehran, Iran.
authors.forename: F S
authors.initials: FS
authors.lastname: Hosseini-Baharanchi
authors.affiliation: Lung Transplant Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: A
authors.initials: A
authors.lastname: Abbasi Dezfuli
keywords: Brain-dead donor; Ex-vivo lung perfusion; Lung transplantation; Lung transplantation technique