title: Experimentalin vivoandex vivomodels for the study of human aortic dissection: promises and challenges.
abstract: Aortic dissection (AD) is a life-threatening aortopathy with high mortality. To mimic spontaneous AD, investigate the pathogenesis of AD and develop novel therapeutic targets and measures, multiple AD experimental models have been generated, including drugs or chemicals induced experimental models, genetically modified experimental models, surgically or invasively induced experimental models, andex vivomodels. However, the perfect model of AD that replicates every aspect of the natural disease has not be generated yet. This review provides an overview of the experimental models used in AD preclinical research. The value and challenges of eachin vivoandex vivomodel are discussed.
authors.affiliation: Division of Cardiothoracic and Vascular Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan 430030, China; Key Laboratory of Organ Transplantation, Ministry of Education, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan 430030, China; Key Laboratory of Organ Transplantation, Ministry of Health, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan 430030, China.
authors.forename: Ding-Sheng
authors.initials: DS
authors.lastname: Jiang
authors.affiliation: Department of Cardiology, Renmin Hospital of Wuhan UniversityWuhan 430060, China; Cardiovascular Research Institute, Wuhan UniversityWuhan 430060, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Yi
authors.affiliation: Division of Cardiothoracic and Vascular Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan 430030, China; Key Laboratory of Organ Transplantation, Ministry of Education, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan 430030, China; Key Laboratory of Organ Transplantation, Ministry of Health, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan 430030, China.
authors.forename: Xue-Hai
authors.initials: XH
authors.lastname: Zhu
authors.affiliation: Division of Cardiothoracic and Vascular Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan 430030, China; Key Laboratory of Organ Transplantation, Ministry of Education, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan 430030, China; Key Laboratory of Organ Transplantation, Ministry of Health, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan 430030, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Wei
keywords: Aortic dissection; angiotensin II; experimental model; marfan syndrome; β-aminopropionitrile monofumarate