title: Visual outcome and refractive status in first 3 years of age in preterm infants suffered from laser-treated Type 1 retinopathy of prematurity (ROP): a 6-year retrospective review in a tertiary centre in Hong Kong.
abstract: OBJECTIVE
  To report the visual outcome and refractive status in first 3 years of age in preterm infants suffered from laser-treated Type 1 retinopathy of prematurity (ROP): a 6-year review in Hong Kong DESIGN: Retrospective case series METHODOLOGY: Clinical records of all infants suffered from Type 1 ROP who had undergone laser therapy between 2007 and 2012 were retrospectively reviewed. Basic demographic data, serial changes of refractive error, visual acuity, severity of ROP and laser were analyzed. Correlation with myopia and astigmatism progression, body weight, height, growth and gestational age were also analyzed.
  
  
  RESULTS
  Among 494 babies screened, 14 Chinese babies (26 eyes) recruited with 1:1 male-to-female ratio in this study. All eyes showed gradual progression of myopia in first 3 years of age but no significant change of astigmatism. Further correlation analysis showed no correlation with laser energy consumed, birth weight (p = 0.14), head circumference growth (p = 0.57) and body weight growth (p = 0.71). However, severity of myopia was related to the post-conceptual age when receiving laser therapy (p < 0.005), gestation age (p = 0.02) and possibly body height growth with age (p = 0.05).
  
  
  CONCLUSIONS
  Myopia in early life is one of the most common ocular sequelae in Type 1 ROP survivors. Early detection of refractive error is important for prompt correction and visual rehabilitation to prevent amblyopia.
authors.affiliation: Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong. lokjulie@yahoo.com.hk.
authors.forename: Julie Y C
authors.initials: JYC
authors.lastname: Lok
authors.affiliation: Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.
authors.forename: Wilson W K
authors.initials: WWK
authors.lastname: Yip
authors.affiliation: Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.
authors.forename: Abbie S W
authors.initials: ASW
authors.lastname: Luk
authors.affiliation: Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.
authors.forename: Joyce K Y
authors.initials: JKY
authors.lastname: Chin
authors.affiliation: Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.
authors.forename: Henry H W
authors.initials: HHW
authors.lastname: Lau
authors.affiliation: Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.
authors.forename: Alvin L
authors.initials: AL
authors.lastname: Young
mesh_terms: D005260:Female; D005500:Follow-Up Studies; D005865:Gestational Age; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D007234:Infant, Premature; D053685:Laser Therapy / Q000379:methods*; D008297:Male; D009216:Myopia / Q000150:complications / Q000503:physiopathology* / Q000601:surgery; D012029:Refraction, Ocular / Q000502:physiology*; D012178:Retinopathy of Prematurity / Q000453:epidemiology / Q000503:physiopathology / Q000601:surgery*; D012189:Retrospective Studies; D062606:Tertiary Care Centers; D013997:Time Factors; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology*
keywords: Laser; Late sequelae; Myopia; Refractive error; Retinopathy of prematurity