title: The influence of gonadotropins on clinico-biological ICSI outcome: a retrospective comparative study rFsH vs HP-hmg.
abstract: Objective To investigate the difference in the outcome of ICSI-ET cycles among respondents patients, taking into account the molecule inducer of controlled ovarian stimulation: HP-hMG ou rFSH. Patients and Methods A comparative retrospective study over 62 months including a total of 1005 infertile couples, divided into two groups: HP-HMG (n=125) and rFSH (n=880). Results - The average numbers of retrieved oocytes and matures oocytes were significantly higher in rFSH group rFSH (7,94 ± 2,49, HP-HMG vs 9,05 ± 3,40, rFSH, p=0.0001and  3±2,68, HP-HMG vs 6,65±3,05 , rFSH, p=0,02 respectively). There was no statistically significant difference in the endometrial thickness and estradiol level on hCG injection day, the total amount of administrated gonadotropin and the duration of stimulation. In addition, we did not find a significant difference between the two groups regarding the fertilization, the maturation, the cleavage, top quality embryo, implantation, clinical pregnancy, multiple pregnancies, live birth and miscarriage rates. There was no case of severe ovarian hyperstimulation syndrome. Conclusion - Inspite of a higher number of retrieved and mature oocytes obtained with rFSH, the latter showed no superiority over HP-hMG which seem to be equally efficient and safe for ICSI treatment cycles.
authors.forename: Abdeljalil
authors.initials: A
authors.lastname: Khlifi
authors.forename: Olfa
authors.initials: O
authors.lastname: Kacem
authors.forename: Maher
authors.initials: M
authors.lastname: Maroueni
authors.forename: Leila
authors.initials: L
authors.lastname: Elgoul
authors.forename: Samir
authors.initials: S
authors.lastname: Hidar
authors.forename: Meriem
authors.initials: M
authors.lastname: Fekih
authors.forename: Sassi
authors.initials: S
authors.lastname: Boughizane
authors.forename: Habib
authors.initials: H
authors.lastname: Essaidi
authors.forename: Lassad
authors.initials: L
authors.lastname: Ben Regaya
authors.forename: Mohamed
authors.initials: M
authors.lastname: Bibi
authors.forename: Mounir
authors.initials: M
authors.lastname: Ajina
authors.forename: Hedi
authors.initials: H
authors.lastname: Khairi
mesh_terms: D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use*; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000627:therapeutic use*; D006728:Hormones / Q000627:therapeutic use*; D006801:Humans; D008596:Menotropins / Q000627:therapeutic use*; D054315:Oocyte Retrieval; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D011994:Recombinant Proteins; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic
chemical_list: D005300:Fertility Agents, Female; D006728:Hormones; D011994:Recombinant Proteins; D008596:Menotropins; D005640:Follicle Stimulating Hormone