title: High Incidence of Escherichia coli Strains Coharboringmcr-1andblaNDMfrom Chickens.
abstract: This study investigated the characteristics ofEscherichia coliisolates carryingmcr-1-blaNDMfrom a chicken farm in China. Of the 78E. coliisolates, 21 clonally unrelated isolates carriedmcr-1-blaNDMDiverse IncI2 plasmids disseminatedmcr-1, while the dissemination ofblaNDMwas mediated by diverse IncB/O plasmids. More striking was the colocalization of resistance genesmcr-1andblaNDM-4in an IncHI2/ST3 plasmid, which might pose a great challenge for public health.
authors.affiliation: College of Animal Science and Veterinary Medicine, Qingdao Agricultural University, Qingdao, China liubaotao-1986@163.com.|Engineering Technology Research Center of Veterinary Medicine and Diagnostic Reagents of Shandong Province, Qingdao Agricultural University, Qingdao, China.
authors.forename: Bao-Tao
authors.initials: BT
authors.lastname: Liu
authors.affiliation: Qingdao Academy of Agricultural Sciences, Qingdao, China.
authors.forename: Feng-Jing
authors.initials: FJ
authors.lastname: Song
authors.affiliation: College of Animal Science and Veterinary Medicine, Qingdao Agricultural University, Qingdao, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Zou
authors.affiliation: College of Animal Science and Veterinary Medicine, Qingdao Agricultural University, Qingdao, China.
authors.forename: Qi-Di
authors.initials: QD
authors.lastname: Zhang
authors.affiliation: College of Animal Science and Veterinary Medicine, Qingdao Agricultural University, Qingdao, China.|Engineering Technology Research Center of Veterinary Medicine and Diagnostic Reagents of Shandong Province, Qingdao Agricultural University, Qingdao, China.
authors.forename: Hu
authors.initials: H
authors.lastname: Shan
mesh_terms: D000822:Animal Husbandry; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D015780:Carbapenems / Q000494:pharmacology; D002645:Chickens; D002681:China / Q000453:epidemiology; D002999:Clone Cells; D003091:Colistin / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics / Q000254:growth & development; D004927:Escherichia coli Infections / Q000188:drug therapy / Q000453:epidemiology / Q000635:transmission / Q000662:veterinary*; D029968:Escherichia coli Proteins / Q000235:genetics* / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D022761:Gene Transfer, Horizontal; D008826:Microbial Sensitivity Tests; D010957:Plasmids / Q000737:chemistry / Q000378:metabolism*; D011201:Poultry Diseases / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology / Q000635:transmission; D001618:beta-Lactamases / Q000235:genetics* / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D029968:Escherichia coli Proteins; C000614037:MCR-1 protein, E coli; D001618:beta-Lactamases; C552864:beta-lactamase NDM-1; D003091:Colistin
keywords: Escherichia coli; blaNDM; colocalization; high incidence; mcr-1