title: Synthesis and insecticidal activity of acridone derivatives to Aedes aegypti and Culex quinquefasciatus larvae and non-target aquatic species.
abstract: A serious Mosquito borne yellow fever is one of the grave diseases which affect the major population. Since there is no specific treatment for yellow fever, there is a necessity to develop an effective agent. The series of acridinone analogues 3 to 5 were synthesized with help of non-conventional microwave heating and confirmed by respective spectral characterization. 5c and 3b showed highest activity to kill 90% of larvae against A. aegypti and C. quinquefasciatus, respectively. Also the active products were treated to check the mortality of non-target aquatic species. Through the reports of the larvicidal bioassay, compounds 3b against C. quinquefasciatus whereas 5c against A. aegypti were found to be more active. By keeping this as a platform, further extension of the work can be done to find out a valuable drug for controlling disease vectors.
authors.affiliation: Chemistry of Heterocycles &Natural Product Research Laboratory, Department of Chemistry, School of Advanced Sciences, VIT University, Vellore-632014, Tamil Nadu, India.
authors.forename: Selvaraj Mohana
authors.initials: SM
authors.lastname: Roopan
authors.affiliation: Chemistry of Heterocycles &Natural Product Research Laboratory, Department of Chemistry, School of Advanced Sciences, VIT University, Vellore-632014, Tamil Nadu, India.
authors.forename: Annadurai
authors.initials: A
authors.lastname: Bharathi
authors.affiliation: Department of Botany and Microbiology, Addiriyah Chair for Environmental Studies, College of Science, King Saud University, P. O. Box 2455, Riyadh, 11451, Saudi Arabia.
authors.forename: Naif Abdullah
authors.initials: NA
authors.lastname: Al-Dhabi
authors.affiliation: Department of Botany and Microbiology, Addiriyah Chair for Environmental Studies, College of Science, King Saud University, P. O. Box 2455, Riyadh, 11451, Saudi Arabia.
authors.forename: Mariadhas Valan
authors.initials: MV
authors.lastname: Arasu
authors.affiliation: Chemistry of Heterocycles &Natural Product Research Laboratory, Department of Chemistry, School of Advanced Sciences, VIT University, Vellore-632014, Tamil Nadu, India.
authors.forename: G
authors.initials: G
authors.lastname: Madhumitha
mesh_terms: D019342:Acetic Acid / Q000138:chemical synthesis; D054831:Acridones / Q000138:chemical synthesis; D000330:Aedes; D000818:Animals; D059001:Aquatic Organisms; D003465:Culex; D006358:Hot Temperature; D006834:Hydrazines / Q000138:chemical synthesis; D007306:Insecticides; D007814:Larva; D053768:Metal Nanoparticles; D008872:Microwaves; D009032:Mosquito Control; D000072138:Mosquito Vectors; D010936:Plant Extracts; D018515:Plant Leaves
chemical_list: D054831:Acridones; D006834:Hydrazines; D007306:Insecticides; D010936:Plant Extracts; C029424:hydrazine; C041300:acridone; D019342:Acetic Acid