title: A Bioluminogenic Probe for Monitoring Tyrosinase Activity.
abstract: A bioluminogenic probe based on luciferin was designed and synthesized to monitor tyrosinase activity. This probe was efficient in assessing tyrosinase activity in a buffered aqueous solution and in measuring endogenous tyrosinase activity in melanoma cells.
authors.affiliation: Molecular Imaging Innovations Institute, Department of Radiology, Weill Cornell Medicine, 413 East 69th Street, New York, NY, 10065, USA.|Current address: School of Chemical and Environmental Engineering, Anyang Institute of Technology, West of HuangHe Road, Anyang, 455000, PR China.
authors.forename: Jianguang
authors.initials: J
authors.lastname: Wang
authors.affiliation: Molecular Imaging Innovations Institute, Department of Radiology, Weill Cornell Medicine, 413 East 69th Street, New York, NY, 10065, USA.|Current address: Division of RI-Convergence Research, Korea Institute of Radiological and Medical Sciences, 75 Nowon-ro, Nowon-gu, Seoul, 01812, Republic of Korea.
authors.forename: Tae Sup
authors.initials: TS
authors.lastname: Lee
authors.affiliation: Molecular Imaging Innovations Institute, Department of Radiology, Weill Cornell Medicine, 413 East 69th Street, New York, NY, 10065, USA.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Molecular Imaging Innovations Institute, Department of Radiology, Weill Cornell Medicine, 413 East 69th Street, New York, NY, 10065, USA.
authors.forename: Ching-Hsuan
authors.initials: CH
authors.lastname: Tung
mesh_terms: D000818:Animals; D001547:Benzaldehydes / Q000737:chemistry; D052160:Benzothiazoles / Q000737:chemistry; D045744:Cell Line, Tumor; D049454:Firefly Luciferin / Q000031:analogs & derivatives* / Q000737:chemistry*; D005453:Fluorescence; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D006835:Hydrazones / Q000737:chemistry; D051379:Mice; D014442:Monophenol Monooxygenase / Q000032:analysis*
chemical_list: D001547:Benzaldehydes; D052160:Benzothiazoles; D005456:Fluorescent Dyes; D006835:Hydrazones; D049454:Firefly Luciferin; D014442:Monophenol Monooxygenase; C002536:3-methyl-2-benzothiazolone hydrazone; C032175:benzaldehyde
keywords: fluorescence; luciferin; luminescence; probes; tyrosinase