title: Expression of Monomeric C-Reactive Protein in Infarcted Brain Tissue from Patients with Alzheimer's Disease.
abstract: OBJECTIVE
  We have previously shown that monomeric-C-reactive protein is deposited in significant quantities within the brain parenchyma after stroke. Since we have recently identified a possible role of this protein in supporting neurodegeneration and aberrant vascular development we identified a small group of post-mortem brain samples from individuals who had Alzheimer's disease and evidence of tissue infarction/ micro-infarction on histological examination.
  
  
  METHODS
  We used immunohistochemistry staining to identify the monomeric-C-reactive protein expressed in the infarcted brain tissues.
  
  
  RESULTS
  We showed that monomeric-C-reactive protein deposition was highest in those regions affected by stroke or vascular disruption, and that within those same areas, there was more interaction and co-localization between major classical proteins of neurodegeneration (β-amyloid and tau).
  
  
  CONCLUSIONS
  We hypothesise that vascular disruption and concomitant release of monomeric-C-reactive protein within the brain tissue could exacerbate ongoing neurological damage via stimulation of neuro-inflammation and from direct consequences of its action on both neuronal and vascular cells.
authors.affiliation: Manchester Metropolitan University, School of Healthcare Science, Manchester, United Kingdom.
authors.forename: Mark
authors.initials: M
authors.lastname: Slevin
authors.forename: Donghui
authors.initials: D
authors.lastname: Liu
authors.forename: Glenn
authors.initials: G
authors.lastname: Ferris
authors.forename: Malik
authors.initials: M
authors.lastname: Al-Hsinawi
authors.forename: Raid
authors.initials: R
authors.lastname: Al-Baradie
authors.forename: Jerzy
authors.initials: J
authors.lastname: Krupinski
mesh_terms: D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications / Q000473:pathology*; D016229:Amyloid beta-Peptides / Q000032:analysis / Q000096:biosynthesis; D020520:Brain Infarction / Q000150:complications / Q000473:pathology*; D002097:C-Reactive Protein / Q000032:analysis / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D016875:tau Proteins / Q000032:analysis / Q000096:biosynthesis
chemical_list: D016229:Amyloid beta-Peptides; D016875:tau Proteins; D002097:C-Reactive Protein