title: Lewis Acid Catalyzed Dehydrogenative Coupling of Tertiary Propargylic Alcohols with Quinoline N-Oxides.
abstract: An unprecedented Lewis acid catalyzed, high-efficiency synthesis of valuable 2-(quinolin-2-yl)prop-2-en-1-ones via dehydrogenative coupling of propargylic alkynols with quinoline N-oxides is described. This protocol, which tolerates a broad range of functional groups, provides a straightforward pathway to the products 2-(quinolin-2-yl)prop-2-en-1-one scaffolds in satisfactory yields. The conversion could be scaled up to gram scale efficiently, which underlines a latent application of this methodology.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou 730000, China.
authors.forename: Ya-Ping
authors.initials: YP
authors.lastname: Han
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou 730000, China.
authors.forename: Xue-Song
authors.initials: XS
authors.lastname: Li
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou 730000, China.
authors.forename: Xin-Yu
authors.initials: XY
authors.lastname: Zhu
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou 730000, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Li
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou 730000, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Jiangxi Key Laboratory of Organic Chemistry, Jiangxi Science Technology Normal University , Nanchang 330013, China.
authors.forename: Xian-Rong
authors.initials: XR
authors.lastname: Song
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou 730000, China.
authors.forename: Yong-Min
authors.identifier: 0000-0001-8280-8211
authors.initials: YM
authors.lastname: Liang