title: Integrated Approaches to Drug Discovery for Oxidative Stress-Related Retinal Diseases.
abstract: Excessive oxidative stress induces dysregulation of functional networks in the retina, resulting in retinal diseases such as glaucoma, age-related macular degeneration, and diabetic retinopathy. Although various therapies have been developed to reduce oxidative stress in retinal diseases, most have failed to show efficacy in clinical trials. This may be due to oversimplification of target selection for such a complex network as oxidative stress. Recent advances in high-throughput technologies have facilitated the collection of multilevel omics data, which has driven growth in public databases and in the development of bioinformatics tools. Integration of the knowledge gained from omics databases can be used to generate disease-related biological networks and to identify potential therapeutic targets within the networks. Here, we provide an overview of integrative approaches in the drug discovery process and provide simple examples of how the approaches can be exploited to identify oxidative stress-related targets for retinal diseases.
authors.affiliation: Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.
authors.forename: Yuhei
authors.identifier: 0000-0003-1901-8799
authors.initials: Y
authors.lastname: Nishimura
authors.affiliation: Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu 501-1196, Japan.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Hara
mesh_terms: D000818:Animals; D055808:Drug Discovery / Q000379:methods*; D053263:Gene Regulatory Networks; D006801:Humans; D058990:Molecular Targeted Therapy; D018384:Oxidative Stress; D012164:Retinal Diseases / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology*