title: Drosophila melanogaster as a Model of Muscle Degeneration Disorders.
abstract: Drosophila melanogaster provides a powerful platform with which researchers can dissect complex genetic questions and biochemical pathways relevant to a vast array of human diseases and disorders. Of particular interest, much work has been done with flies to elucidate the molecular mechanisms underlying muscle degeneration diseases. The fly is particularly useful for modeling muscle degeneration disorders because there are no identified satellite muscle cells to repair adult muscle following injury. This allows for the identification of endogenous processes of muscle degeneration as discrete events, distinguishable from phenotypes due to the lack of stem cell-based regeneration. In this review, we will discuss the ways in which the fruit fly provides a powerful platform with which to study human muscle degeneration disorders.
authors.affiliation: University of Washington, School of Medicine, Seattle, WA, United States; Institute for Stem Cell and Regenerative Medicine, University of Washington, School of Medicine, Seattle, WA, United States.
authors.forename: R E
authors.initials: RE
authors.lastname: Kreipke
authors.affiliation: University of Washington, School of Medicine, Seattle, WA, United States.
authors.forename: Y V
authors.initials: YV
authors.lastname: Kwon
authors.affiliation: Max Planck Research Group of Gene Expression and Signaling, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
authors.forename: H R
authors.initials: HR
authors.lastname: Shcherbata
authors.affiliation: University of Washington, School of Medicine, Seattle, WA, United States; Institute for Stem Cell and Regenerative Medicine, University of Washington, School of Medicine, Seattle, WA, United States. Electronic address: hannele@uw.edu.
authors.forename: H
authors.initials: H
authors.lastname: Ruohola-Baker
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004331:Drosophila melanogaster / Q000502:physiology*; D006801:Humans; D018482:Muscle, Skeletal / Q000473:pathology*; D009135:Muscular Diseases / Q000473:pathology* / Q000628:therapy; D015398:Signal Transduction
keywords: Cachexia; Motor neuron diseases; Muscle degeneration; Muscle wasting; Muscular dystrophy