title: Honeycomb structural composite polymer network of gelatin and functional cellulose ester for controlled release of omeprazole.
abstract: The functionalized cellulose ester MCN was firstly synthesized and used to cross-link gelatin by amidation between -NH2in gelatin and active ester groups in MCN to form a composite polymer network Gel-MCN, which was confirmed by Van Slyke method, FTIR, XRD and TGA-DTG spectra. The model drug omeprazole was loaded in Gel-MCN composites mainly by electrostatic interaction and hydrogen bonds, which were certified by FTIR, XRD and TGA-DSC. Thermal stability, anti-biodegradability, mechanical property and surface hydrophobicity of the composites with different cross-linking extents and drug loading were systematically investigated. SEM images demonstrated the honeycomb structural cells of cross-linked gelatin networks and this ensured drug entrapment. The drug release mechanism was dominated by a combined effect of diffusion and degradation, and the release rate decreased with cross-linking degree increased. The developed drug delivery system had profound significance in improving pesticide effect and bioavailability of drugs.
authors.affiliation: Shandong Provincial Key Laboratory of Fine Chemicals, Qilu University of Technology, Jinan, 250353, PR China.
authors.forename: Chen
authors.initials: C
authors.lastname: Zhuang
authors.affiliation: Shandong Provincial Key Laboratory of Fine Chemicals, Qilu University of Technology, Jinan, 250353, PR China.
authors.forename: Chengmei
authors.initials: C
authors.lastname: Shi
authors.affiliation: Shandong Provincial Key Laboratory of Fine Chemicals, Qilu University of Technology, Jinan, 250353, PR China. Electronic address: frao2015@126.com.
authors.forename: Furong
authors.initials: F
authors.lastname: Tao
authors.affiliation: Shandong Provincial Key Laboratory of Fine Chemicals, Qilu University of Technology, Jinan, 250353, PR China.
authors.forename: Yuezhi
authors.initials: Y
authors.lastname: Cui
mesh_terms: D002482:Cellulose / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D004355:Drug Stability; D004952:Esters / Q000737:chemistry*; D005780:Gelatin / Q000737:chemistry*; D009853:Omeprazole / Q000737:chemistry*; D013696:Temperature
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004952:Esters; D005780:Gelatin; D002482:Cellulose; D009853:Omeprazole
keywords: Controlled release; Cross-linking; Gelatin; Microcrystalline cellulose; Omeprazole