title: Influence of Liver Inflammation on Liver Stiffness Measurement in Patients with Autoimmune Hepatitis Evaluation by Combinational Elastography.
abstract: OBJECTIVE
  In order to evaluate the influence of liver inflammation on liver stiffness measurement (LSM) by the simultaneous use of shear wave and strain imaging (combinational elastography), shear wave and strain imaging were compared before and after initial therapy for autoimmune hepatitis (AIH).
  
  
  METHODS
  Nine AIH patients initially treated with steroid were enrolled. Transient elastography and real-time tissue elastography were performed just before and 1 month after the start of initial steroid treatment. Blood samples, LSM, and the liver fibrosis index (LFI) were compared.
  
  
  RESULTS
  Aspartate aminotransferase (p = 0.002) and alanine aminotransferase (ALT) (p = 0.015) were significantly decreased after initial treatment. The LSM was 15.5 ± 9.6 kPa at baseline, decreasing to 7.2 ± 2.3 kPa after initial treatment p = 0.034). The LFI was 1.67 ± 0.67 at baseline and 1.61 ± 0.66 after initial treatment; no significant change in LFI was recognized (p = 0.842). Between ΔALT and ΔLSM, a significant regression equation could be calculated as follows: ΔALT = -0.55 + 0.654 × ΔLSM.
  
  
  CONCLUSIONS
  Combinational elastography was useful in evaluating not only the degree of liver fibrosis, but also the degree of liver inflammation in AIH.
authors.affiliation: Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-Sayama, Japan.
authors.forename: Norihisa
authors.initials: N
authors.lastname: Yada
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Sakurai
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Minami
authors.forename: Tadaaki
authors.initials: T
authors.lastname: Arizumi
authors.forename: Masahiro
authors.initials: M
authors.lastname: Takita
authors.forename: Satoru
authors.initials: S
authors.lastname: Hagiwara
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ida
authors.forename: Kazuomi
authors.initials: K
authors.lastname: Ueshima
authors.forename: Naoshi
authors.initials: N
authors.lastname: Nishida
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Kudo
mesh_terms: D000368:Aged; D000410:Alanine Transaminase / Q000097:blood / Q000378:metabolism; D001219:Aspartate Aminotransferases / Q000097:blood / Q000378:metabolism; D054459:Elasticity Imaging Techniques / Q000379:methods; D005260:Female; D019693:Hepatitis, Autoimmune / Q000097:blood / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D011446:Prospective Studies; D013256:Steroids / Q000627:therapeutic use
chemical_list: D013256:Steroids; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase