title: A phytotoxic bicyclic lactone and other compounds from endophyte Xylaria curta.
abstract: A new compound, (3aS,6aR)-4,5-dimethyl-3,3a,6,6a-tetrahydro-2H-cyclopenta [b]furan-2-one (2), along with two known metabolites, myrotheciumone A (1) and 4-oxo-4H-pyron-3-acetic acid (3) was isolated from the ethyl acetate extract of fermentation broth of Xylaria curta 92092022. The structures of these compounds were elucidated on the basis of spectroscopic methods (UV, IR, HRESITOFMS, 1D NMR, and 2D NMR). Compounds 1 and 2 showed moderate antibacterial and phytotoxic activities.
authors.affiliation: a Department of Organic Chemistry , University of Yaounde 1 , Yaounde , Cameroon.
authors.forename: Abdou
authors.initials: A
authors.lastname: Tchoukoua
authors.affiliation: b Department of Food, Life, and Environmental Science, Faculty of Agriculture , Yamagata University , Tsuruoka , Japan.
authors.forename: Takuma
authors.initials: T
authors.lastname: Ota
authors.affiliation: b Department of Food, Life, and Environmental Science, Faculty of Agriculture , Yamagata University , Tsuruoka , Japan.
authors.forename: Rima
authors.initials: R
authors.lastname: Akanuma
authors.affiliation: c Institute of Plant and Microbial Biology, Academia Sinica, Nankang , Taipei , Taiwan.
authors.forename: Yu-Ming
authors.initials: YM
authors.lastname: Ju
authors.affiliation: d Department of Chemistry, Faculty of Mathematics and Natural Sciences , Universitas Padjadjaran , Sumedang , Indonesia.
authors.forename: Unang
authors.initials: U
authors.lastname: Supratman
authors.affiliation: b Department of Food, Life, and Environmental Science, Faculty of Agriculture , Yamagata University , Tsuruoka , Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Murayama
authors.affiliation: b Department of Food, Life, and Environmental Science, Faculty of Agriculture , Yamagata University , Tsuruoka , Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Koseki
authors.affiliation: b Department of Food, Life, and Environmental Science, Faculty of Agriculture , Yamagata University , Tsuruoka , Japan.
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Shiono
mesh_terms: D000085:Acetates / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D003517:Cyclopentanes / Q000737:chemistry; D004353:Drug Evaluation, Preclinical; D060026:Endophytes / Q000737:chemistry; D005285:Fermentation; D005663:Furans / Q000737:chemistry; D007783:Lactones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D018545:Lactuca / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011753:Pyrones / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet; D018675:Toxicity Tests; D013098:Xylariales / Q000737:chemistry*
chemical_list: C000624338:(3aS,6aR)-4,5-dimethyl-3,3a,6,6a-tetrahydro-2H-cyclopenta(b)furan-2-one; C000624337:4-oxo-4H-pyron-3-acetic acid; D000085:Acetates; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D019086:Bridged Bicyclo Compounds, Heterocyclic; D003517:Cyclopentanes; D005663:Furans; D007783:Lactones; D011753:Pyrones; C000593991:myrotheciumone A; C007650:ethyl acetate
keywords: Endophyte; Xylaria curta; antimicrobial activity; cyclopenta[b]furan; myrotheciumone A; phytotoxicity