title: Hyperparathyroidism caused by distant pulmonary lesions and parathyromatosis after ethanol injection/parathyroidectomy for secondary hyperparathyroidism.
abstract: Secondary hyperparathyroidism (SHPT) treatment includes parathyroidectomy and percutaneous ethanol injection therapy (PEIT), which are invasive procedures. The condition in which benign hyperfunctioning parathyroid tissue is distributed throughout the neck and mediastinum is termed parathyromatosis. Here, we present the case of a 51-year-old woman who began hemodialysis in 1986 due to chronic kidney disease of unknown etiology and developed SHPT in 1999. She underwent 6 rounds of PEIT followed by total a parathyroidectomy with partial forearm autotransplantation. Between 2011 and 2013, surgeons removed several nodules from her pulmonary and cervical regions and the transplanted masses from her forearm; all showed hyperplasia but exhibited no histological evidence of malignancy. Damage to the parathyroid capsule after repeated PEITs may cause local cervical recurrence and pulmonary lesions, although distant lesions are extremely rare in SHPT. This case is of interest due to the possible association between PEIT and parathyromatosis and distal lesions.
authors.affiliation: Department of Transplant Surgery, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
authors.forename: Michio
authors.initials: M
authors.lastname: Nakamura
authors.affiliation: Kidney Center, Minatoku, Tokyo, Japan.
authors.forename: Kiho
authors.initials: K
authors.lastname: Tanaka
authors.affiliation: Department of Pathology, Toranomon Hospital, Minatoku, Tokyo, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Fujii
mesh_terms: D000431:Ethanol / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000150:complications* / Q000473:pathology; D006962:Hyperparathyroidism, Secondary / Q000473:pathology / Q000601:surgery*; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy; D008875:Middle Aged; D010280:Parathyroid Glands / Q000473:pathology*; D016105:Parathyroidectomy / Q000379:methods*; D006435:Renal Dialysis / Q000009:adverse effects*
chemical_list: D000431:Ethanol
keywords: Chronic renal failure; parathyroidectomy; parathyromatosis; percutaneous ethanol injection therapy (PEIT); secondary hyperparathyroidism