title: (S)Pot on Mitochondria: Cannabinoids Disrupt Cellular Respiration to Limit Neuronal Activity.
abstract: Classical views posit G protein-coupled cannabinoid receptor 1s (CB1Rs) at the cell surface with cytosolic Giα-mediated signal transduction. Hebert-Chatelain et al. (2016) instead place CB1Rs at mitochondria limiting neuronal respiration by soluble adenylyl cyclase-dependent modulation of complex I activity. Thus, neuronal bioenergetics link to synaptic plasticity and, globally, learning and memory.
authors.affiliation: Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, 1090 Vienna, Austria; Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden. Electronic address: tibor.harkany@meduniwien.ac.at.
authors.forename: Tibor
authors.initials: T
authors.lastname: Harkany
authors.affiliation: Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06510, USA.
authors.forename: Tamas L
authors.initials: TL
authors.lastname: Horvath
mesh_terms: D002186:Cannabinoids; D006801:Humans; D008568:Memory; D008928:Mitochondria; D043884:Receptor, Cannabinoid, CB1; D043882:Receptors, Cannabinoid; D015398:Signal Transduction
chemical_list: D002186:Cannabinoids; D043884:Receptor, Cannabinoid, CB1; D043882:Receptors, Cannabinoid
keywords: GPCR; THC; axonal growth; bioenergetics; cannabinoid; cannabinoid receptor 1; cannabis; endocannabinoid; mitochondrial import; respiration