title: Prostate-Specific Membrane Antigen PET/CT: Uptake in Lymph Nodes With Active Sarcoidosis.
abstract: We describe 2 cases of Ga-PSMA PET/CT in prostate cancer patients. Both cases demonstrated symmetrical bilateral involvement of mediastinal and hilar lymph nodes besides findings in relation with prostatic disease. In both cases, endobronchial ultrasound-guided biopsy showed that the involvement of the thoracic lymph nodes was caused by nonnecrotic granulomas compatible with sarcoidosis. The cases demonstrated that increased Ga-PSMA uptake can be seen in lymph nodes with active sarcoidosis, with images mimicking those well known from FDG PET/CT. Because of these findings, granulomatous disease has to be included in the differential diagnostic evaluation of patients with Ga-PSMA-positive lymph nodes.
authors.affiliation: From the Department of Nuclear Medicine & PET Center, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: André Henrique
authors.initials: AH
authors.lastname: Dias
authors.forename: Mikkel
authors.initials: M
authors.lastname: Holm Vendelbo
authors.forename: Kirsten
authors.initials: K
authors.lastname: Bouchelouche
mesh_terms: D000368:Aged; D004492:Edetic Acid / Q000031:analogs & derivatives; D061765:Endoscopic Ultrasound-Guided Fine Needle Aspiration; D005709:Gallium Isotopes; D005710:Gallium Radioisotopes; D006801:Humans; D061705:Image-Guided Biopsy; D008198:Lymph Nodes / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008482:Mediastinum / Q000000981:diagnostic imaging*; D008875:Middle Aged; D009842:Oligopeptides; D009942:Organometallic Compounds; D000072078:Positron Emission Tomography Computed Tomography; D011471:Prostatic Neoplasms / Q000150:complications; D012507:Sarcoidosis / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology
chemical_list: D005709:Gallium Isotopes; D005710:Gallium Radioisotopes; D009842:Oligopeptides; D009942:Organometallic Compounds; C000718244:gallium 68 PSMA-11; D004492:Edetic Acid