title: Created of Warm Blood and Nerves: Restoring an Enteric Nervous System in Organoids.
abstract: The enteric nervous system (ENS) regulates numerous gastrointestinal functions, including epithelial barrier permeability and motility. In a recent Nature Medicine study, Workman et al. (2016) propose a method for introducing human pluripotent stem cell-derived enteric neural crest cells into developing human intestinal organoids, thereby restoring ENS cell types and contractile function.
authors.affiliation: The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.
authors.forename: Christopher R
authors.initials: CR
authors.lastname: Schlieve
authors.affiliation: The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA. Electronic address: tgrikscheit@chla.usc.edu.
authors.forename: Tracy C
authors.initials: TC
authors.lastname: Grikscheit
mesh_terms: D002465:Cell Movement; D017615:Enteric Nervous System; D006801:Humans; D007422:Intestines; D009432:Neural Crest; D009940:Organoids