title: Hydralazine is involved in tele-methylhistamine metabolism by inhibiting monoamine oxidase B in pregnancy-associated hypertensive mice.
abstract: Hypertensive disorders of pregnancy globally affect 6-8% of gestation and remain a major cause of both foetal and maternal morbidity and mortality. However, the antihypertensive medications for the patients of this disease are strictly limited due to the teratogenic potentials. Here, we found that tele-methylhistamine (tMH) increased in response to the administration of hydralazine (Hdz), a vasodilative agent, in the pregnancy-associated hypertensive (PAH) mice. Hdz abrogated the degradation of tMH catalyzed by monoamine oxidase B (MAO-B) in vitro. These results suggested that Hdz inhibited the MAO-B activity and consequently tMH increased in the maternal circulation of PAH mice.
authors.affiliation: Graduate School of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan.
authors.forename: Shohei
authors.initials: S
authors.lastname: Kawasaki
authors.affiliation: Faculty of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan.
authors.forename: Koichiro
authors.initials: K
authors.lastname: Kako
authors.affiliation: Graduate School of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Nagashima
authors.affiliation: Graduate School of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Kanou
authors.affiliation: Life Science Center of Tsukuba Advanced Research Alliance, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan.
authors.forename: Junji
authors.initials: J
authors.lastname: Ishida
authors.affiliation: Life Science Center of Tsukuba Advanced Research Alliance, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan.
authors.forename: Akiyoshi
authors.initials: A
authors.lastname: Fukamizu
mesh_terms: D000588:Amines / Q000097:blood; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology; D055162:Biocatalysis / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D005260:Female; D006801:Humans; D006830:Hydralazine / Q000494:pharmacology*; D046110:Hypertension, Pregnancy-Induced / Q000188:drug therapy* / Q000201:enzymology / Q000378:metabolism; D008761:Methylhistamines / Q000097:blood / Q000378:metabolism*; D051379:Mice; D008995:Monoamine Oxidase / Q000378:metabolism*; D011247:Pregnancy; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013379:Substrate Specificity
chemical_list: D000588:Amines; D000959:Antihypertensive Agents; D008761:Methylhistamines; D006830:Hydralazine; D008995:Monoamine Oxidase; C020404:tele-methylhistamine
keywords: hydralazine; hypertensive disorders of pregnancy; monoamine oxidase B; pregnancy-associated hypertensive mice; tele-methylhistamine