title: [Investigation on immunization program coverage rate and its safety in children with tuberous sclerosis].
abstract: Objective:To investigate the status of immunization of National Immunization Program (NIP) and its adverse reaction rate in children with tuberous sclerosis.Method:Questionnaire survey was adopted to identify the vaccination coverage and its adverse events; 72 cases of children with tuberous sclerosis and 78 normal controls (healthy children completing age-appropriate NIP) admitted to Chinese People's Liberation Army General Hospital from December 2014 to November 2015 were involved into this study.Result:The age-appropriate NIP coverage rate of tuberous sclerosis was 36%(26/72). The coverage rate of bacillus calmette-guerin (BCG), hepatitis B vaccine 1stto 3rddoses (HepB1-3), oral poliovaccine 1stdose (OPV1), diphtheria, pertussis and tetanus 1stdose (DPT1), DPT1-3, meningococcal polysaccharide vaccine group A (MPVA), measles amd rubella vaccine/measles vaccine 1stdose (MRV/MCV1), and Japanese encephalitis vaccine 1stdose (JEV1) were 100%(72 cases), 75%(51 cases), 97%(66 cases), 91%(62 cases), 82%(56 cases), 66%(45 cases), 69%(42 cases), and 61%(37 cases) respectively. The reasons why the children did not complete the vaccination plan were that parents were concerned about vaccination-induced seizures or seizures had not been controlled. Among 72 children with TSC, the rate of adverse events or suspected adverse events after vaccination was 17% (12 cases), which was higher than the normal control children (2 cases, 3%) (χ2=8.799,P<0.05). The main adverse events were seizure events, which accounted for 92%(11 cases).Conclusion:The age-appropriate NIP coverage rate among children with tuberous sclerosis is low. The high incidence of adverse events may be associated with a fact that there are some nervous system abnormalities in cases with tuberous sclerosis. TSC children vaccination is relatively safe, with no serious adverse events.
authors.affiliation: Department of Pediatrics, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Gao
authors.forename: L P
authors.initials: LP
authors.lastname: Zou
authors.forename: M N
authors.initials: MN
authors.lastname: Zhang
authors.forename: L Y
authors.initials: LY
authors.lastname: Pang
authors.forename: Y Y
authors.initials: YY
authors.lastname: Wang
authors.forename: S F
authors.initials: SF
authors.lastname: Ma
authors.forename: L L
authors.initials: LL
authors.lastname: Huang
mesh_terms: D002648:Child; D002675:Child, Preschool; D017325:Hepatitis B Vaccines; D006801:Humans; D007114:Immunization; D017589:Immunization Programs; D007223:Infant; D008457:Measles; D010290:Parents; D014402:Tuberous Sclerosis; D014611:Vaccination / Q000009:adverse effects*
chemical_list: D017325:Hepatitis B Vaccines