title: Exercise Training Promotes Functional Recovery after Spinal Cord Injury.
abstract: The exercise training is an effective therapy for spinal cord injury which has been applied to clinic. Traditionally, the exercise training has been considered to improve spinal cord function only through enhancement, compensation, and replacement of the remaining function of nerve and muscle. Recently, accumulating evidences indicated that exercise training can improve the function in different levels from end-effector organ such as skeletal muscle to cerebral cortex through reshaping skeletal muscle structure and muscle fiber type, regulating physiological and metabolic function of motor neurons in the spinal cord and remodeling function of the cerebral cortex. We compiled published data collected in different animal models and clinical studies into a succinct review of the current state of knowledge.
authors.affiliation: Department of Rehabilitation Medicine of 1st Affiliated Hospital of Nanjing Medical University, School of Rehabilitation Medicine of Nanjing Medical University, Nanjing, China; Binzhou Medical University, Yantai, China.
authors.forename: Juanjuan
authors.initials: J
authors.lastname: Fu
authors.affiliation: Department of Rehabilitation Medicine of 1st Affiliated Hospital of Nanjing Medical University, School of Rehabilitation Medicine of Nanjing Medical University, Nanjing, China.
authors.forename: Hongxing
authors.identifier: 0000-0002-0868-3243
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Neurological Surgery, Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University, Indianapolis, IN, USA.
authors.forename: Lingxiao
authors.initials: L
authors.lastname: Deng
authors.affiliation: Department of Rehabilitation Medicine of 1st Affiliated Hospital of Nanjing Medical University, School of Rehabilitation Medicine of Nanjing Medical University, Nanjing, China.
authors.forename: Jianan
authors.initials: J
authors.lastname: Li
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000502:physiology; D015444:Exercise / Q000502:physiology*; D005081:Exercise Therapy / Q000379:methods; D006801:Humans; D009046:Motor Neurons / Q000502:physiology; D018482:Muscle, Skeletal / Q000502:physiology; D020127:Recovery of Function / Q000502:physiology*; D013119:Spinal Cord Injuries / Q000175:diagnosis / Q000503:physiopathology / Q000534:rehabilitation*