title: Effect of Interleukin-27 Genetic Variants on Atrial Fibrillation Susceptibility.
abstract: OBJECTIVE
  Atrial fibrillation (AF) is the most common cardiac arrhythmia. No data are available on the association between the polymorphisms of interleukin-27 (IL-27) and AF in the Chinese Han population. This study was performed to determine if polymorphisms within the IL-27 gene are involved in the AF susceptibility.
  
  
  METHODS
  Two hundred seventy AF patients and 303 healthy individuals were examined for two IL-27 gene polymorphisms (rs153109 and rs17855750) by polymerase chain reaction-restriction fragment length polymorphism methodology.
  
  
  RESULTS
  An association between the IL-27 single nucleotide polymorphism (SNP) rs153109 and AF was found in Chinese Han population. The G allele and GG genotype of rs153109 were associated with increased AF risk (odds ratio [OR]: 1.35, 95% confidence intervals [CI] = 1.06-1.71, p = 0.02 and OR: 1.66, 95% CI = 1.03-2.65, p = 0.03 in the recessive genetic model, respectively). The significance of the association between the GG genotype and AF risk did not survive a Bonferroni's correction. Similarly, no significant differences in the allele and genotype frequencies of the rs17855750 SNP was observed between the AF patients and controls.
  
  
  CONCLUSIONS
  Our findings indicated that the IL-27 genetic polymorphisms may be associated with susceptibility of AF in Chinese Han population.
authors.affiliation: 1 Department of Cardiology, Hospital of The University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital , Chengdu, China .
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.affiliation: 2 Department of Cardiology, The Affiliated Hospital of North Sichuan Medical College , Nanchong, China .
authors.forename: Jianhui
authors.initials: J
authors.lastname: Zeng
authors.affiliation: 3 Department of Cardiovascular Surgery, The Seventh People's Hospital of Chengdu , Chengdu, China .|4 Department of Cardiovascular Surgery, West China Hospital of Sichuan University , Chengdu, China .
authors.forename: Rui
authors.initials: R
authors.lastname: Zhang
authors.affiliation: 5 Department of Cardiology, West China Hospital of Sichuan University , Chengdu, China .
authors.forename: Linjun
authors.initials: L
authors.lastname: Zeng
authors.affiliation: 5 Department of Cardiology, West China Hospital of Sichuan University , Chengdu, China .
authors.forename: Yajiao
authors.initials: Y
authors.lastname: Li
authors.affiliation: 6 Department of Ophthalmology, West China Hospital of Sichuan University , Chengdu, China .
authors.forename: Hong
authors.initials: H
authors.lastname: Wei
authors.affiliation: 5 Department of Cardiology, West China Hospital of Sichuan University , Chengdu, China .
authors.forename: Qing
authors.initials: Q
authors.lastname: Yang
mesh_terms: D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics; D001281:Atrial Fibrillation / Q000235:genetics* / Q000378:metabolism; D016022:Case-Control Studies; D002681:China; D005006:Ethnicity / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D007378:Interleukins / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D007378:Interleukins; C464565:MYDGF protein, human
keywords: IL-27; atrial fibrillation; genetic variant; polymorphism