title: Devilish Effects of Taz in Nonalcoholic Steatohepatitis.
abstract: Nonalcoholic steatohepatitis leads to cirrhosis and cancer in a rising number of patients with metabolic syndrome. In this issue of Cell Metabolism, Wang et al. (2016) identify the transcriptional co-activator Taz as a driver of inflammation and fibrosis through the induction of Indian hedgehog in hepatocytes, which stimulates fibrogenesis by hepatic stellate cells.
authors.affiliation: Division of Liver Diseases, The Icahn School of Medicine at Mount Sinai, 1425 Madison Ave., New York, NY 10029, USA. Electronic address: scott.friedman@mssm.edu.
authors.forename: Scott L
authors.initials: SL
authors.lastname: Friedman
authors.affiliation: Division of Liver Diseases, The Icahn School of Medicine at Mount Sinai, 1425 Madison Ave., New York, NY 10029, USA.
authors.forename: Youngmin A
authors.initials: YA
authors.lastname: Lee
mesh_terms: D005234:Fatty Liver; D055166:Hepatic Stellate Cells; D022781:Hepatocytes / Q000187:drug effects; D006801:Humans; D007249:Inflammation; D008103:Liver Cirrhosis; D065626:Non-alcoholic Fatty Liver Disease