title: Staphylococcus pseudintermedius Human Infection Cases in Spain: Dog-to-Human Transmission.
abstract: Staphylococcus pseudintermedius is an opportunistic pathogen that has been identified as infectious agent or colonizer mainly in dogs. S. pseudintermedius has been also detected in humans and more specifically in people in contact with dogs. In this study, the possible S. pseudintermedius pet-to-human transmission was analyzed in four clinical human cases. Two patients were dog owners and S. pseudintermedius was also detected as colonizer in these healthy animals. S. pseudintermedius isolates from patients and dogs of the same household showed identical pulsed-field gel electrophoresis patterns, sequence types (STs), and antimicrobial resistance phenotypes and genotypes, and were methicillin susceptible. Resistance to erythromycin, clindamycin, tetracycline, trimetoprim-sulfamethoxazole, and/or ciprofloxacin was identified among S. pseudintermedius strains. The lineages ST241 and the new ST521 were detected in the strains of the two dog-owner patients, respectively. The strains from the other two patients presented two new STs, ST719 and ST720. To our knowledge, this is the first description of human infections caused by S. pseudintermedius in Spain.
authors.affiliation: 1 Área Bioquímica y Biología Molecular, Universidad de La Rioja , Logroño, Spain .|2 Área Microbiología Molecular, Centro de Investigación Biomédica de la Rioja , Logroño, Spain .
authors.forename: Carmen
authors.initials: C
authors.lastname: Lozano
authors.affiliation: 3 Servicio de Microbiología, Hospital Universitario Miguel Servet , Zaragoza, Spain .|4 Universidad de Zaragoza , Zaragoza, Spain .|5 IIS Aragón , Zaragoza, Spain .
authors.forename: Antonio
authors.initials: A
authors.lastname: Rezusta
authors.affiliation: 3 Servicio de Microbiología, Hospital Universitario Miguel Servet , Zaragoza, Spain .|4 Universidad de Zaragoza , Zaragoza, Spain .|5 IIS Aragón , Zaragoza, Spain .
authors.forename: Isabel
authors.initials: I
authors.lastname: Ferrer
authors.affiliation: 4 Universidad de Zaragoza , Zaragoza, Spain .
authors.forename: Vanesa
authors.initials: V
authors.lastname: Pérez-Laguna
authors.affiliation: 1 Área Bioquímica y Biología Molecular, Universidad de La Rioja , Logroño, Spain .
authors.forename: Myriam
authors.initials: M
authors.lastname: Zarazaga
authors.affiliation: 1 Área Bioquímica y Biología Molecular, Universidad de La Rioja , Logroño, Spain .
authors.forename: Laura
authors.initials: L
authors.lastname: Ruiz-Ripa
authors.affiliation: 3 Servicio de Microbiología, Hospital Universitario Miguel Servet , Zaragoza, Spain .
authors.forename: María José
authors.initials: MJ
authors.lastname: Revillo
authors.affiliation: 1 Área Bioquímica y Biología Molecular, Universidad de La Rioja , Logroño, Spain .|2 Área Microbiología Molecular, Centro de Investigación Biomédica de la Rioja , Logroño, Spain .
authors.forename: Carmen
authors.initials: C
authors.lastname: Torres
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002481:Cellulitis / Q000453:epidemiology / Q000382:microbiology; D004283:Dog Diseases / Q000382:microbiology* / Q000635:transmission; D004285:Dogs; D024881:Drug Resistance, Bacterial; D016523:Foot Ulcer / Q000453:epidemiology / Q000382:microbiology; D006801:Humans; D013030:Spain / Q000453:epidemiology; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000382:microbiology / Q000635:transmission / Q000662:veterinary*; D013210:Staphylococcus / Q000145:classification* / Q000187:drug effects; D013530:Surgical Wound Infection / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology; D015047:Zoonoses
chemical_list: D000900:Anti-Bacterial Agents
keywords: S. pseudintermedius; ST241; ST521; human; transmission