title: Rational design of vaccine targets and strategies for HIV: a crossroad of statistical physics, biology, and medicine.
abstract: Vaccination has saved more lives than any other medical procedure. Pathogens have now evolved that have not succumbed to vaccination using the empirical paradigms pioneered by Pasteur and Jenner. Vaccine design strategies that are based on a mechanistic understanding of the pertinent immunology and virology are required to confront and eliminate these scourges. In this perspective, we describe just a few examples of work aimed to achieve this goal by bringing together approaches from statistical physics with biology and clinical research.
authors.affiliation: Departments of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States of America. Departments of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139, United States of America. Departments of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, United States of America. Departments of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States of America. Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA 02139, United States of America. Ragon Institute of MIT, MGH, & Harvard, Cambridge, MA 02139, United States of America.
authors.forename: Arup K
authors.initials: AK
authors.lastname: Chakraborty
authors.forename: John P
authors.initials: JP
authors.lastname: Barton
mesh_terms: D016915:AIDS Vaccines / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D006678:HIV / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity; D015658:HIV Infections / Q000378:metabolism / Q000517:prevention & control / Q000821:virology; D006801:Humans; D014611:Vaccination
chemical_list: D016915:AIDS Vaccines