title: Biocompatible Polymeric Analogues of DMSO Prepared by Atom Transfer Radical Polymerization.
abstract: The synthesis of a sulfoxide-based water-soluble polymer, poly(2-(methylsulfinyl)ethyl acrylate) (polyMSEA), a polymeric analogue of DMSO, by atom transfer radical polymerization (ATRP) is reported. Well-defined linear polymers were synthesized using relatively low amounts of copper catalyst (1000 or 100 ppm). Two types of star polymers were synthesized by either an "arm-first" approach or a "core-first" approach using a biodegradable β-cyclodextrin core. The glass transition temperatures of both the linear polymer (16 °C) and star polymer (32 °C) were determined by differential scanning calorimetry (DSC). The lower critical solution temperature (LCST) of poly(MSEA) was estimated to be ca. 140 °C by extrapolating the LCST of a series of copolymers with NIPAM. Cytotoxicity tests revealed that both the linear and star polymers have low toxicity, even at concentrations up to 3 mg/mL.
authors.affiliation: Department of Chemistry, Carnegie Mellon University , 4400 Fifth Avenue, Pittsburgh, Pennsylvania 15213, United States.
authors.forename: Sipei
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Chemistry, Carnegie Mellon University , 4400 Fifth Avenue, Pittsburgh, Pennsylvania 15213, United States.
authors.forename: Hee Sung
authors.initials: HS
authors.lastname: Chung
authors.affiliation: Department of Chemistry, Carnegie Mellon University , 4400 Fifth Avenue, Pittsburgh, Pennsylvania 15213, United States.
authors.forename: Antonina
authors.initials: A
authors.lastname: Simakova
authors.affiliation: Department of Chemistry, Carnegie Mellon University , 4400 Fifth Avenue, Pittsburgh, Pennsylvania 15213, United States.
authors.forename: Zongyu
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Chemistry, Carnegie Mellon University , 4400 Fifth Avenue, Pittsburgh, Pennsylvania 15213, United States.
authors.forename: Sangwoo
authors.initials: S
authors.lastname: Park
authors.affiliation: Department of Chemistry, Carnegie Mellon University , 4400 Fifth Avenue, Pittsburgh, Pennsylvania 15213, United States.
authors.forename: Liye
authors.initials: L
authors.lastname: Fu
authors.affiliation: Allegheny Health Network - Neuroscience Disruptive Research Lab, 320 East North Avenue, Pittsburgh, Pennsylvania 15212, United States.
authors.forename: Devora
authors.initials: D
authors.lastname: Cohen-Karni
authors.affiliation: Allegheny Health Network - Neuroscience Disruptive Research Lab, 320 East North Avenue, Pittsburgh, Pennsylvania 15212, United States.
authors.forename: Saadyah
authors.identifier: 0000-0003-4775-2317
authors.initials: S
authors.lastname: Averick
authors.affiliation: Department of Chemistry, Carnegie Mellon University , 4400 Fifth Avenue, Pittsburgh, Pennsylvania 15213, United States.
authors.forename: Krzysztof
authors.identifier: 0000-0003-1960-3402
authors.initials: K
authors.lastname: Matyjaszewski
mesh_terms: D001672:Biocompatible Materials / Q000008:administration & dosage* / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D002384:Catalysis; D002470:Cell Survival / Q000187:drug effects; D004121:Dimethyl Sulfoxide / Q000737:chemistry*; D057809:HEK293 Cells; D006801:Humans; D058105:Polymerization; D011108:Polymers / Q000008:administration & dosage* / Q000737:chemistry; D044366:Transition Temperature; D014867:Water / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D011108:Polymers; D014867:Water; D004121:Dimethyl Sulfoxide