title: meta-C-H Bromination on Purine Bases by Heterogeneous Ruthenium Catalysis.
abstract: Methods for positionally selective remote C-H functionalizations are in high demand. Herein, we disclose the first heterogeneous ruthenium catalyst for meta-selective C-H functionalizations, which enabled remote halogenations with excellent site selectivity and ample scope. The versatile heterogeneous Ru@SiO2catalyst was broadly applicable and could be easily recovered and reused, which set the stage for the direct fluorescent labeling of purines. In contrast to palladium, rhodium, iridium, or cobalt complexes, solely the ruthenium catalysis manifold provided access to meta-halogenated purine derivatives, illustrating the unique power of ruthenium C-H activation catalysis.
authors.affiliation: Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstrasse 2, 37077, Göttingen, Germany.
authors.forename: Svenja
authors.initials: S
authors.lastname: Warratz
authors.affiliation: Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstrasse 2, 37077, Göttingen, Germany.
authors.forename: David J
authors.initials: DJ
authors.lastname: Burns
authors.affiliation: Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstrasse 2, 37077, Göttingen, Germany.
authors.forename: Cuiju
authors.initials: C
authors.lastname: Zhu
authors.affiliation: Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstrasse 2, 37077, Göttingen, Germany.
authors.forename: Korkit
authors.initials: K
authors.lastname: Korvorapun
authors.affiliation: Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstrasse 2, 37077, Göttingen, Germany.
authors.forename: Torben
authors.initials: T
authors.lastname: Rogge
authors.affiliation: Institut für Materialphysik, Georg-August-Universität Göttingen, Friedrich-Hund-Platz 1, 37077, Göttingen, Germany.
authors.forename: Julius
authors.initials: J
authors.lastname: Scholz
authors.affiliation: Institut für Materialphysik, Georg-August-Universität Göttingen, Friedrich-Hund-Platz 1, 37077, Göttingen, Germany.|International Center for Advanced Studies of Energy Conversion (ICASEC), Georg-August University of Göttingen, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Jooss
authors.affiliation: Institute of Chemistry, The Hebrew University, Edmond Safra Campus, 91904, Jerusalem, Israel.
authors.forename: Dmitri
authors.initials: D
authors.lastname: Gelman
authors.affiliation: Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstrasse 2, 37077, Göttingen, Germany.|International Center for Advanced Studies of Energy Conversion (ICASEC), Georg-August University of Göttingen, Germany.
authors.forename: Lutz
authors.identifier: 0000-0001-7034-8772
authors.initials: L
authors.lastname: Ackermann
keywords: C−H activation; heterogeneous catalysis; meta selectivity; nucleobases; ruthenium