title: Mycobacterium avium Complex Septic Arthritis Presenting as Osteonecrosis of the Femoral Head in a Patient With Systemic Lupus Erythematosus.
abstract: Mycobacterium avium complex is a rare cause of musculoskeletal infection, usually occurring in patients with compromised immune systems. Obtaining the diagnosis requires a high index of suspicion, and treatment can be delayed because of difficulty with isolating the organism. Treatment involves prolonged, targeted combination antibiotic therapy, and it is unclear whether eradication of the infection can occur in the presence of a foreign body, such as antibiotic spacers. The authors report a case of M avium infection presenting as presumed osteonecrosis of the femoral head in a young woman with systemic lupus erythematosus. She presented with collapse of her femoral head coinciding with several months of progressive, debilitating hip pain. She had mild fevers during that time, but results from multiple infectious workups, including hip aspiration, were negative. Purulent fluid was found in the operating room, but diagnosis was delayed for 5 weeks while waiting for cultures. The patient required 3 subsequent operations, eventually being left with a resection arthroplasty. Pertinent issues concerning diagnosis, therapy, and treatment challenges in M avium infections of the musculoskeletal system are discussed in this case report. [Orthopedics. 2017; 40(3):e549-e552.].
authors.forename: Alexander B
authors.initials: AB
authors.lastname: Christ
authors.forename: Elena V
authors.initials: EV
authors.lastname: Zininberg
authors.forename: Kethy M
authors.initials: KM
authors.lastname: Jules-Elysee
authors.forename: Michael L
authors.initials: ML
authors.lastname: Parks
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D001170:Arthritis, Infectious / Q000150:complications / Q000175:diagnosis* / Q000382:microbiology; D004359:Drug Therapy, Combination; D005260:Female; D005270:Femur Head / Q000382:microbiology; D005271:Femur Head Necrosis / Q000382:microbiology* / Q000601:surgery; D006801:Humans; D016867:Immunocompromised Host; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000175:diagnosis / Q000382:microbiology; D015269:Mycobacterium avium Complex; D015270:Mycobacterium avium-intracellulare Infection / Q000150:complications / Q000175:diagnosis* / Q000382:microbiology; D061665:Time-to-Treatment; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents