title: Quality of life 10 years after liver transplantation: The impact of graft histology.
abstract: OBJECTIVE
  To evaluate the relationship between the state of transplanted liver graft and the recipient quality of life (QOL) of histologically proven lesions in a 10-year post liver transplantation (LT) cohort of patients.
  
  
  METHODS
  Seventy-two recipients with a functional first graft at 10 years post-LT underwent liver biopsy and completed a QOL questionnaire. Logistic regression analysis was used to explore associations between histological, clinical and QOL criteria.
  
  
  RESULTS
  Ten years after LT, fibrosis was detected in 53% of patients, and affected the general health perception, while ductopenia, present in 36%, affected the well-being (P= 0.05). Hepatic steatosis (HS) was present in 33% of patients and was associated with the worst QOL score on multiple domains. When compared to patients without HS, patients with HS had significantly higher incidence of fibrosis (P= 0.03), hepatitis C virus (HCV) infection (P= 0.007), and more patients had retired from their job (P= 0.03). Recurrent orde novoHCV-associated fibrosis and patient retirement as objective variables, and abdominal pain or discomfort and joint aches or pains as subjective variables, emerged as independent determinants of HS.
  
  
  CONCLUSIONS
  Long-term liver graft lesions, mainly HS presumably as a surrogate marker of HCV infection, may have a substantial impact on QOL 10 years after LT.
authors.affiliation: Vincent Karam, Mylène Sebagh, Colette Danet, Faouzi Saliba, Didier Samuel, Denis Castaing, René Adam, Centre Hépatobiliaire, Assistance Publique-Hôpitaux de Paris, Université Paris-Sud, Hôpital Paul Brousse, F-94804 Villejuif, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Karam
authors.affiliation: Vincent Karam, Mylène Sebagh, Colette Danet, Faouzi Saliba, Didier Samuel, Denis Castaing, René Adam, Centre Hépatobiliaire, Assistance Publique-Hôpitaux de Paris, Université Paris-Sud, Hôpital Paul Brousse, F-94804 Villejuif, France.
authors.forename: Mylène
authors.initials: M
authors.lastname: Sebagh
authors.affiliation: Vincent Karam, Mylène Sebagh, Colette Danet, Faouzi Saliba, Didier Samuel, Denis Castaing, René Adam, Centre Hépatobiliaire, Assistance Publique-Hôpitaux de Paris, Université Paris-Sud, Hôpital Paul Brousse, F-94804 Villejuif, France.
authors.forename: Kinan
authors.initials: K
authors.lastname: Rifai
authors.affiliation: Vincent Karam, Mylène Sebagh, Colette Danet, Faouzi Saliba, Didier Samuel, Denis Castaing, René Adam, Centre Hépatobiliaire, Assistance Publique-Hôpitaux de Paris, Université Paris-Sud, Hôpital Paul Brousse, F-94804 Villejuif, France.
authors.forename: Funda
authors.initials: F
authors.lastname: Yilmaz
authors.affiliation: Vincent Karam, Mylène Sebagh, Colette Danet, Faouzi Saliba, Didier Samuel, Denis Castaing, René Adam, Centre Hépatobiliaire, Assistance Publique-Hôpitaux de Paris, Université Paris-Sud, Hôpital Paul Brousse, F-94804 Villejuif, France.
authors.forename: Prashant
authors.initials: P
authors.lastname: Bhangui
authors.affiliation: Vincent Karam, Mylène Sebagh, Colette Danet, Faouzi Saliba, Didier Samuel, Denis Castaing, René Adam, Centre Hépatobiliaire, Assistance Publique-Hôpitaux de Paris, Université Paris-Sud, Hôpital Paul Brousse, F-94804 Villejuif, France.
authors.forename: Colette
authors.initials: C
authors.lastname: Danet
authors.affiliation: Vincent Karam, Mylène Sebagh, Colette Danet, Faouzi Saliba, Didier Samuel, Denis Castaing, René Adam, Centre Hépatobiliaire, Assistance Publique-Hôpitaux de Paris, Université Paris-Sud, Hôpital Paul Brousse, F-94804 Villejuif, France.
authors.forename: Faouzi
authors.initials: F
authors.lastname: Saliba
authors.affiliation: Vincent Karam, Mylène Sebagh, Colette Danet, Faouzi Saliba, Didier Samuel, Denis Castaing, René Adam, Centre Hépatobiliaire, Assistance Publique-Hôpitaux de Paris, Université Paris-Sud, Hôpital Paul Brousse, F-94804 Villejuif, France.
authors.forename: Didier
authors.initials: D
authors.lastname: Samuel
authors.affiliation: Vincent Karam, Mylène Sebagh, Colette Danet, Faouzi Saliba, Didier Samuel, Denis Castaing, René Adam, Centre Hépatobiliaire, Assistance Publique-Hôpitaux de Paris, Université Paris-Sud, Hôpital Paul Brousse, F-94804 Villejuif, France.
authors.forename: Denis
authors.initials: D
authors.lastname: Castaing
authors.affiliation: Vincent Karam, Mylène Sebagh, Colette Danet, Faouzi Saliba, Didier Samuel, Denis Castaing, René Adam, Centre Hépatobiliaire, Assistance Publique-Hôpitaux de Paris, Université Paris-Sud, Hôpital Paul Brousse, F-94804 Villejuif, France.
authors.forename: René
authors.initials: R
authors.lastname: Adam
authors.affiliation: Vincent Karam, Mylène Sebagh, Colette Danet, Faouzi Saliba, Didier Samuel, Denis Castaing, René Adam, Centre Hépatobiliaire, Assistance Publique-Hôpitaux de Paris, Université Paris-Sud, Hôpital Paul Brousse, F-94804 Villejuif, France.
authors.forename: Cyrille
authors.initials: C
authors.lastname: Feray
keywords: Hepatic steatosis; Liver biopsy; Liver fibrosis; Liver transplantation; Quality of life