title: Prostate Cancer in a Patient with a Family History of BRCA Mutation: a Case Report and Literature Review.
abstract: One of the most significant risk factors for prostate cancer (PC) is a family history of the disease, with germ-line mutations in the breast cancer predisposition gene (BRCA) 2 conferring the highest risk. We here report a 56-year-old man presented with painful gait disturbance and diagnosed PC with multiple disseminated bone metastases. The patient had a strong family history of breast cancer with his 2 nieces affected. Furthermore, his aunts and uncles from both sides were diagnosed with stomach, ovarian, and colorectal cancers. His genomic sequencing analysis of the BRCA genes revealed the same BRCA2 deleterious mutation that his breast cancer-affected nieces carried. Previous studies have suggested that BRCA2-mutated PC is associated with a more aggressive phenotype and poor prognosis. Our experience in the present case also indicated the urgent needs for novel treatment modality and PC screening in this high-risk group of patients.
authors.affiliation: Department of Urology, Seoul National University Hospital, Seoul, Korea.
authors.forename: Won Hoon
authors.identifier: http://orcid.org/0000-0003-1930-6045
authors.initials: WH
authors.lastname: Song
authors.affiliation: Department of Urology, Center for Prostate Cancer, National Cancer Center, Goyang, Korea.
authors.forename: Sung Han
authors.identifier: http://orcid.org/0000-0002-1689-5203
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Department of Urology, Center for Prostate Cancer, National Cancer Center, Goyang, Korea.
authors.forename: Jae Young
authors.identifier: http://orcid.org/0000-0003-2954-1663
authors.initials: JY
authors.lastname: Joung
authors.affiliation: Department of Urology, Center for Prostate Cancer, National Cancer Center, Goyang, Korea.|Department of Pathology, Center for Prostate Cancer, National Cancer Center, Goyang, Korea.
authors.forename: Weon Seo
authors.identifier: http://orcid.org/0000-0002-0035-1455
authors.initials: WS
authors.lastname: Park
authors.affiliation: Department of Urology, Center for Prostate Cancer, National Cancer Center, Goyang, Korea.
authors.forename: Ho Kyung
authors.identifier: http://orcid.org/0000-0003-2601-1093
authors.initials: HK
authors.lastname: Seo
authors.affiliation: Department of Urology, Center for Prostate Cancer, National Cancer Center, Goyang, Korea.
authors.forename: Jinsoo
authors.identifier: http://orcid.org/0000-0003-2251-5331
authors.initials: J
authors.lastname: Chung
authors.affiliation: Department of Urology, Center for Prostate Cancer, National Cancer Center, Goyang, Korea. uroonco@ncc.re.kr.
authors.forename: Kang Hyun
authors.identifier: http://orcid.org/0000-0003-0041-2243
authors.initials: KH
authors.lastname: Lee
mesh_terms: D024682:BRCA2 Protein / Q000235:genetics*; D001842:Bone and Bones / Q000000981:diagnostic imaging; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009154:Mutation; D010375:Pedigree; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology
chemical_list: D024682:BRCA2 Protein; C551750:BRCA2 protein, human; D017430:Prostate-Specific Antigen
keywords: BRCA; Family History; Genetic Mutation; Prostate Cancer