title: Lugrandoside attenuates LPS-induced acute respiratory distress syndrome by anti-inflammation and anti-apoptosis in mice.
abstract: This study aimed to investigate the protective effects and specific mechanisms of lugrandoside (LG) on lipopolysaccharides (LPS)-induced acute respiratory distress syndrome (ARDS). LG is a novel phenylpropanoid glycoside with many biological properties, isolated from the culinary leaves of Digitalis lutea L. and Digitalis grandiflora Miller. The primary indicators to assess the lung injury were infiltration of inflammatory cells; pulmonary edema; expression of proinflammatory cytokines, cyclo-oxygenase 2, and intracellular adhesion molecule 1; activation of nuclear factor-κB pathways; and cellular apoptosis. The results showed that LG evidently alleviated the inflammatory response, decreased the apoptosis of alveolar macrophages, and improved the lung injury in mice with LPS-induced ARDS. In conclusion, LG improved LPS-induced ARDS by anti-inflammation and anti-apoptosis and might be a promising pharmacological therapy for ARDS.
authors.affiliation: Department of Anesthesiology, Shanghai Pulmonary Hospital, Tongji University School of MedicineShanghai, China; Department of Medicine, Hebei North UniversityZhangjiakou, Hebei, China.
authors.forename: Chengbao
authors.initials: C
authors.lastname: Li
authors.affiliation: Jiangsu Province Key Laboratory of Anesthesiology and Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University Xuzhou, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Department of Medicine, Hebei North University Zhangjiakou, Hebei, China.
authors.forename: Xueya
authors.initials: X
authors.lastname: Yao
authors.affiliation: Department of Anesthesiology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center Shanghai, China.
authors.forename: Baoji
authors.initials: B
authors.lastname: Hu
authors.affiliation: Department of Anesthesiology, Ningxiang People's Hospital of Hunan Province Ningxiang, Hunan, China.
authors.forename: Suzhen
authors.initials: S
authors.lastname: Wu
authors.affiliation: Department of Anesthesiology, Shanghai Pulmonary Hospital, Tongji University School of Medicine Shanghai, China.
authors.forename: Guannan
authors.initials: G
authors.lastname: Chen
authors.affiliation: Department of Anesthesiology, Shanghai Pulmonary Hospital, Tongji University School of MedicineShanghai, China; Shanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of MedicineShanghai, China; Jiangsu Province Key Laboratory of Anesthesiology and Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical UniversityXuzhou, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Lv
authors.affiliation: Department of Anesthesiology, Shanghai Obstetrics and Gynecology Hospital, Fudan University Shanghai, China.
authors.forename: Fubo
authors.initials: F
authors.lastname: Tian
keywords: Acute respiratory distress syndrome; anti-apoptosis; anti-inflammation; lipopolysaccharide; lugrandoside