title: Embryotoxic effects of Poincianella ( Caesalpinia) pyramidalis leaves on pregnant rats.
abstract: We investigated the embryotoxic and fetotoxic effects of Poincianella pyramidalis (Tul.) L.P. Queiroz (syn. Caesalpinia pyramidalis Tul.) leaves on pregnant rats ( Rattus norvegicus). Pregnant rats were divided into 4 groups: G1-fed a ration containing 5% P. pyramidalis leaves beginning on day 1 of pregnancy; G2-fed a ration containing 5% P. pyramidalis leaves commencing on day 6 of pregnancy; G3-fed a ration containing 10% P. pyramidalis leaves starting on day 6 of pregnancy; G4-control group. On day 21 of pregnancy, parameters of reproductive performance were recorded. Fetal growth was measured, and fetuses were subjected to external examination and identification of skeletal anomalies. Rations containing P. pyramidalis resulted in dead or undeveloped fetuses and reduced the number, length, and weight of the fetuses. Rations also increased postimplantation losses and the frequency of skeletal anomalies. Furthermore, P. pyramidalis was also responsible for dose-dependent lesions in the placentas. In conclusion, the ingestion of P. pyramidalis promotes fetal and placental damage.
authors.affiliation: Veterinary Hospital, Universidade Federal Rural do Semi-Árido, Mossoró, Rio Grande do Norte, Brazil (Câmara, Gadelha).|Veterinary Pathology Laboratory, Universidade de Brasília (UNB).|Brasilia, Distrito Federal, Brazil (Castro).|Veterinary Hospital, Universidade Federal de Campina Grande, Patos, Paraíba, Brazil (Medeiros, Riet-Correa).|Department of Veterinary Clinics and Surgery, Veterinary School, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil (Soto-Blanco).
authors.forename: Antônio Carlos L
authors.initials: AC
authors.lastname: Câmara
authors.affiliation: Veterinary Hospital, Universidade Federal Rural do Semi-Árido, Mossoró, Rio Grande do Norte, Brazil (Câmara, Gadelha).|Veterinary Pathology Laboratory, Universidade de Brasília (UNB).|Brasilia, Distrito Federal, Brazil (Castro).|Veterinary Hospital, Universidade Federal de Campina Grande, Patos, Paraíba, Brazil (Medeiros, Riet-Correa).|Department of Veterinary Clinics and Surgery, Veterinary School, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil (Soto-Blanco).
authors.forename: Ivana Cristina N
authors.initials: IC
authors.lastname: Gadelha
authors.affiliation: Veterinary Hospital, Universidade Federal Rural do Semi-Árido, Mossoró, Rio Grande do Norte, Brazil (Câmara, Gadelha).|Veterinary Pathology Laboratory, Universidade de Brasília (UNB).|Brasilia, Distrito Federal, Brazil (Castro).|Veterinary Hospital, Universidade Federal de Campina Grande, Patos, Paraíba, Brazil (Medeiros, Riet-Correa).|Department of Veterinary Clinics and Surgery, Veterinary School, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil (Soto-Blanco).
authors.forename: Márcio B
authors.initials: MB
authors.lastname: Castro
authors.affiliation: Veterinary Hospital, Universidade Federal Rural do Semi-Árido, Mossoró, Rio Grande do Norte, Brazil (Câmara, Gadelha).|Veterinary Pathology Laboratory, Universidade de Brasília (UNB).|Brasilia, Distrito Federal, Brazil (Castro).|Veterinary Hospital, Universidade Federal de Campina Grande, Patos, Paraíba, Brazil (Medeiros, Riet-Correa).|Department of Veterinary Clinics and Surgery, Veterinary School, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil (Soto-Blanco).
authors.forename: Rosane Maria T
authors.initials: RM
authors.lastname: Medeiros
authors.affiliation: Veterinary Hospital, Universidade Federal Rural do Semi-Árido, Mossoró, Rio Grande do Norte, Brazil (Câmara, Gadelha).|Veterinary Pathology Laboratory, Universidade de Brasília (UNB).|Brasilia, Distrito Federal, Brazil (Castro).|Veterinary Hospital, Universidade Federal de Campina Grande, Patos, Paraíba, Brazil (Medeiros, Riet-Correa).|Department of Veterinary Clinics and Surgery, Veterinary School, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil (Soto-Blanco).
authors.forename: Franklin
authors.initials: F
authors.lastname: Riet-Correa
authors.affiliation: Veterinary Hospital, Universidade Federal Rural do Semi-Árido, Mossoró, Rio Grande do Norte, Brazil (Câmara, Gadelha).|Veterinary Pathology Laboratory, Universidade de Brasília (UNB).|Brasilia, Distrito Federal, Brazil (Castro).|Veterinary Hospital, Universidade Federal de Campina Grande, Patos, Paraíba, Brazil (Medeiros, Riet-Correa).|Department of Veterinary Clinics and Surgery, Veterinary School, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil (Soto-Blanco).
authors.forename: Benito
authors.initials: B
authors.lastname: Soto-Blanco
mesh_terms: D000818:Animals; D029911:Caesalpinia; D004622:Embryo, Mammalian / Q000002:abnormalities*; D005260:Female; D015511:Goat Diseases / Q000209:etiology; D006041:Goats; D008297:Male; D010920:Placenta / Q000473:pathology; D018515:Plant Leaves / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D012756:Sheep; D012757:Sheep Diseases / Q000209:etiology; D013723:Teratogens / Q000633:toxicity*; D018675:Toxicity Tests
chemical_list: D013723:Teratogens
keywords: Fabaceae; Leguminosae; malformations; poisonous plants; rats; reproductive toxicology; teratogenic plants