title: Clinical and magnetic resonance imaging features of compressive cervical myelopathy with traumatic intervertebral disc herniation in cynomolgus macaque (Macaca fascicularis).
abstract: Intervertebral disc herniation (IVDH) with nucleus pulposus extrusion, traumatic or not, is a devastating clinical condition accompanied by neurological problems. Here we report a cynomolgus macaque suffering from acute and progressive neurological dysfunction by a blunt trauma due to neck collar, an animal handling device. Tetraplegia, urinary incontinence, decreased proprioception, and imperception of pain were shown on physical and neurological examinations. MRI sagittal T2 weighted sequences revealed an extensive protrusion of disc material between C2 and C3 cervical vertebra, and this protrusion resulted in central stenosis of the spinal cord. Histopathologic findings showed a large number of inflammatory cells infiltrated at sites of spinal cord injury (SCI). This case is the first report of compressive cervical SCI caused by IVDH associated with blunt trauma.
authors.affiliation: Transplantation Research Institute, Medical Research Center, Department of Medicine, Seoul National University College of Medicine, Seoul, Korea.; Department of Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Yun-Jung
authors.initials: YJ
authors.lastname: Choi
authors.affiliation: Transplantation Research Institute, Medical Research Center, Department of Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Hye-Jin
authors.initials: HJ
authors.lastname: Park
authors.affiliation: Department of Radiology, Seoul National University Hospital, Seoul, Korea.
authors.forename: Chul-Ho
authors.initials: CH
authors.lastname: Sohn
authors.affiliation: Transplantation Research Institute, Medical Research Center, Department of Medicine, Seoul National University College of Medicine, Seoul, Korea.; Department of Pathology, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Kyeong Cheon
authors.initials: KC
authors.lastname: Jung
authors.affiliation: Transplantation Research Institute, Medical Research Center, Department of Medicine, Seoul National University College of Medicine, Seoul, Korea.; Department of Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Seong Hoe
authors.initials: SH
authors.lastname: Park
authors.affiliation: Transplantation Research Institute, Medical Research Center, Department of Medicine, Seoul National University College of Medicine, Seoul, Korea.; Department of Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Jae-Il
authors.initials: JI
authors.lastname: Lee
keywords: Intervertebral disc herniation; blunt trauma; cynomolgus macaque; spinal cord injury; tetraplegia