title: DNA Replication Checkpoint: New ATR Activator Identified.
abstract: The ATR kinase is a master regulator of replication stress responses. Four new studies show that the protein ETAA1 is an important activator of ATR in human cells, providing insights into how the ATR pathway reacts to replication stress.
authors.affiliation: MGH Cancer Center & Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA. Electronic address: LZOU1@mgh.harvard.edu.
authors.forename: Lee
authors.initials: L
authors.lastname: Zou
mesh_terms: D000954:Antigens, Surface / Q000235:genetics; D064007:Ataxia Telangiectasia Mutated Proteins / Q000235:genetics; D002352:Carrier Proteins / Q000235:genetics*; D059447:Cell Cycle Checkpoints; D004247:DNA / Q000235:genetics; D004261:DNA Replication; D006801:Humans
chemical_list: D000954:Antigens, Surface; D002352:Carrier Proteins; C508506:ETAA1 protein, human; D004247:DNA; C576597:ATR protein, human; D064007:Ataxia Telangiectasia Mutated Proteins