title: Positive association between physical activity and PER3 expression in older adults.
abstract: The circadian clock regulates many physiological functions including physical activity and feeding patterns. In addition, scheduled exercise and feeding themselves can affect the circadian clock. The purpose of the present study was to investigate the relationship between physical/feeding activity and expression of clock genes in hair follicle cells in older adults. Twenty adult men (age, 68 ± 7 years, mean ± SE) were examined in this cross-sectional study. Prior to hair follicle cell collection, the participants were asked to wear a uniaxial accelerometer for one week. The timings of breakfast, lunch, and dinner were also recorded. Hair follicle cells were then collected over a 24 h period at 4 h intervals. The amplitude of PER3 expression was positively correlated with moderate and vigorous physical activity (r = 0.582, p = 0.007) and peak oxygen uptake (r = 0.481, p = 0.032), but these correlations were not observed for NR1D1 or NR1D2. No association was noted between meal times and the amplitude or the acrophase for any of these three clock genes. These findings suggest that rhythmic expression of the circadian clock gene PER3 is associated with the amount of daily physical activity and physical fitness in older adults.
authors.affiliation: Faculty of Science and Engineering, Waseda Univesity, Shinjuku, 162-8480, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Takahashi
authors.affiliation: Graduate School of Advanced Science and Engineering, Waseda Univesity, Shinjuku, 162-8480, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Haraguchi
authors.affiliation: Waseda Institute for Advanced Study, Waseda University, Shinjuku, 162-8480, Japan.
authors.forename: Yu
authors.initials: Y
authors.lastname: Tahara
authors.affiliation: Faculty of Science and Engineering, Waseda Univesity, Shinjuku, 162-8480, Japan.
authors.forename: Natsumi
authors.initials: N
authors.lastname: Aoki
authors.affiliation: Graduate School of Advanced Science and Engineering, Waseda Univesity, Shinjuku, 162-8480, Japan.
authors.forename: Mayuko
authors.initials: M
authors.lastname: Fukazawa
authors.affiliation: Faculty of Sports Sciences, Waseda University, Tokorozawa, 359-1192, Japan.
authors.forename: Kumpei
authors.initials: K
authors.lastname: Tanisawa
authors.affiliation: Faculty of Sports Sciences, Waseda University, Tokorozawa, 359-1192, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Ito
authors.affiliation: Department of Medicine, Tokyo Women's Medical University, Medical Center East, Arakawa, Tokyo, 116-8567, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakaoka
authors.affiliation: Faculty of Sports Sciences, Waseda University, Tokorozawa, 359-1192, Japan.|Institute of Advanced Active Aging Research, Waseda University, Tokorozawa, 359-1192, Japan.
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Higuchi
authors.affiliation: Faculty of Science and Engineering, Waseda Univesity, Shinjuku, 162-8480, Japan.|Institute of Advanced Active Aging Research, Waseda University, Tokorozawa, 359-1192, Japan.
authors.forename: Shigenobu
authors.initials: S
authors.lastname: Shibata
mesh_terms: D000328:Adult; D000368:Aged; D056926:CLOCK Proteins / Q000235:genetics; D057906:Circadian Clocks; D003430:Cross-Sectional Studies; D015444:Exercise / Q000502:physiology*; D005260:Female; D018859:Hair Follicle / Q000378:metabolism; D006801:Humans; D008297:Male; D062407:Meals / Q000502:physiology*; D008875:Middle Aged; D056950:Period Circadian Proteins / Q000235:genetics / Q000276:immunology*; D010507:Periodicity
chemical_list: C512644:PER3 protein, human; D056950:Period Circadian Proteins; D056926:CLOCK Proteins