title: Sleep, lung function, and quality of life in patients with myasthenia gravis: A cross-sectional study.
abstract: The purpose of this study was to investigate the physiological variables of lung function, respiratory muscle strength, and sleep in clinically stable patients with myasthenia gravis. This was a prospective cross-sectional study conducted in accordance with the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement. Patients adhering to the eligibility criteria were consecutively recruited from the Research Department of Neuromuscular Diseases at the Federal University of Sao Paulo and the Department of Neurology at Santa Casa de Misericordia of Sao Paulo and were referred to the Nove de Julho University Sleep Laboratory (Sao Paulo, Brazil). The study included 25 patients (21 female) with a mean age of 45.28 ± 12.33 years. Only one patient exhibited a restrictive ventilatory pattern. The maximum ventilatory pressures observed were considerably reduced in most patients as compared to reference values. In sleep studies, the patients exhibited significantly reduced oxygen saturation, reduced rapid eye movement sleep time, increased non-rapid eye movement stage 3 sleep, and considerable apnoea/hypopnoea indexes. Clinically stable patients with myasthenia gravis exhibit a high prevalence of sleep-disordered breathing, significant reductions in maximum ventilatory pressures, and impairment of health-related quality of life.
authors.affiliation: Sleep Laboratory, Rehabilitation Sciences Master's and PhD Degree Program, Nove de Julho University - UNINOVE, Sao Paulo, SP, Brazil.
authors.forename: Ezequiel Fernandes
authors.initials: EF
authors.lastname: Oliveira
authors.affiliation: Department of Doenças do Aparelho Respiratório, Instituto de Assistência Medica do Servidor Publico Estadual - IAMSPE, Sao Paulo, SP, Brazil.
authors.forename: Sergio Roberto
authors.initials: SR
authors.lastname: Nacif
authors.affiliation: Sleep Laboratory, Rehabilitation Sciences Master's and PhD Degree Program, Nove de Julho University - UNINOVE, Sao Paulo, SP, Brazil.
authors.forename: Jessica Julioti
authors.initials: JJ
authors.lastname: Urbano
authors.affiliation: Sleep Laboratory, Rehabilitation Sciences Master's and PhD Degree Program, Nove de Julho University - UNINOVE, Sao Paulo, SP, Brazil.
authors.forename: Anderson Soares
authors.initials: AS
authors.lastname: Silva
authors.affiliation: Sleep Laboratory, Rehabilitation Sciences Master's and PhD Degree Program, Nove de Julho University - UNINOVE, Sao Paulo, SP, Brazil.
authors.forename: Claudia Santos
authors.initials: CS
authors.lastname: Oliveira
authors.affiliation: Faculdade de Ciencias Medicas da Santa Casa de Sao Paulo, Sao Paulo, SP, Brazil.
authors.forename: Eduardo Araujo
authors.initials: EA
authors.lastname: Perez
authors.affiliation: Faculdade de Ciencias Medicas da Santa Casa de Sao Paulo, Sao Paulo, SP, Brazil.
authors.forename: Melissa Nunes
authors.initials: MN
authors.lastname: Polaro
authors.affiliation: Faculdade de Ciencias Medicas da Santa Casa de Sao Paulo, Sao Paulo, SP, Brazil.
authors.forename: Berenice Cataldo Oliveira
authors.initials: BCO
authors.lastname: Valerio
authors.affiliation: Faculdade de Ciencias Medicas da Santa Casa de Sao Paulo, Sao Paulo, SP, Brazil.
authors.forename: Roberto
authors.initials: R
authors.lastname: Stirbulov
authors.affiliation: National Research Council of Italy, Institute of Biomedicine and Molecular Immunology Alberto Monroy - CNR, Palermo, SI, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Insalaco
authors.affiliation: Department of Neurology and Neurosurgery, Division of Neuromuscular Disorders, Federal University of Sao Paulo - UNIFESP, Sao Paulo, SP, Brazil.
authors.forename: Acary Sousa Bulle
authors.initials: ASB
authors.lastname: Oliveira
authors.affiliation: Sleep Laboratory, Rehabilitation Sciences Master's and PhD Degree Program, Nove de Julho University - UNINOVE, Sao Paulo, SP, Brazil. Electronic address: oliveira.lvf@pq.cnpq.br.
authors.forename: Luis Vicente Franco
authors.initials: LVF
authors.lastname: Oliveira
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000150:complications / Q000503:physiopathology*; D011788:Quality of Life; D012120:Respiration Disorders / Q000209:etiology / Q000503:physiopathology*; D012129:Respiratory Function Tests; D012132:Respiratory Muscles / Q000503:physiopathology; D012893:Sleep Wake Disorders / Q000209:etiology / Q000503:physiopathology*
keywords: Health-related quality of life; Myasthenia gravis; Respiratory function test; Sleep