title: Hemospray for treatment of acute bleeding due to upper gastrointestinal tumours.
abstract: BACKGROUND
  Hemospray is a new endoscopic haemostatic powder that can be used in the management of upper gastrointestinal bleedings.
  
  
  OBJECTIVE
  To assess the efficacy and safety of Hemospray as monotherapy for the treatment of acute upper gastrointestinal bleeding due to cancer.
  
  
  METHODS
  The endoscopy databases of 3 Italian Endoscopic Units were reviewed retrospectively and 15 patients (8 males; mean age 74 years) were included in this study.
  
  
  RESULTS
  Immediate haemostasis was achieved in 93% of cases. Among the successful cases, 3 re-bled, one case treated with Hemospray and injection had a good outcome, while 2 cases died both re-treated with Hemospray, injection and thermal therapy. No complications related to Hemospray occurred. Finally, 80% of patients had a good clinical outcome at 30days and 50% at six months.
  
  
  CONCLUSIONS
  Hemospray may be considered an effective and safe method for the endoscopic management of acute neoplastic upper gastrointestinal bleedings.
authors.affiliation: Digestive Endoscopy Unit, San Paolo Hospital, 20142 Milano, Italy.
authors.forename: Monica
authors.initials: M
authors.lastname: Arena
authors.affiliation: Diagnostic and Therapeutic Endoscopy Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milano, Italy.
authors.forename: Enzo
authors.initials: E
authors.lastname: Masci
authors.affiliation: Gastroenterology and Endoscopy Unit, Department of Medical and Surgical Sciences, Sant'Orsola University Hospital, Bologna, Italy.
authors.forename: Leonardo Henry
authors.initials: LH
authors.lastname: Eusebi
authors.affiliation: Digestive Endoscopy Unit, San Paolo Hospital, 20142 Milano, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Iabichino
authors.affiliation: Gastroenterology and Digestive Endoscopy Unit, General Hospital of Sanremo, 18038 Sanremo, Italy.
authors.forename: Benedetto
authors.initials: B
authors.lastname: Mangiavillano
authors.affiliation: Digestive Endoscopy Unit, San Paolo Hospital, 20142 Milano, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Viaggi
authors.affiliation: Digestive Endoscopy Unit, San Paolo Hospital, 20142 Milano, Italy.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Morandi
authors.affiliation: Division of Gastroenterology and Gastrointestinal Endoscopy, Vita-Salute San Raffaele University, Scientific Institute San Raffaele, Milan, Italy.
authors.forename: Lorella
authors.initials: L
authors.lastname: Fanti
authors.affiliation: Endoscopy Service, Department of Diagnostic and Therapeutic Services, IRCCS-ISMETT, Palermo, Italy.
authors.forename: Antonino
authors.initials: A
authors.lastname: Granata
authors.affiliation: Endoscopy Service, Department of Diagnostic and Therapeutic Services, IRCCS-ISMETT, Palermo, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Traina
authors.affiliation: Division of Gastroenterology and Gastrointestinal Endoscopy, Vita-Salute San Raffaele University, Scientific Institute San Raffaele, Milan, Italy.
authors.forename: Pier Alberto
authors.initials: PA
authors.lastname: Testoni
authors.affiliation: Hepatobiliopancreatic and Digestive Surgery Unit, Department of Surgery, San Paolo Hospital, University of Milan, Italy.
authors.forename: Enrico
authors.initials: E
authors.lastname: Opocher
authors.affiliation: Digestive Endoscopy Unit, San Paolo Hospital, 20142 Milano, Italy. Electronic address: carmeluigiano@libero.it.
authors.forename: Carmelo
authors.initials: C
authors.lastname: Luigiano
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D016099:Endoscopy, Gastrointestinal; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy* / Q000209:etiology; D005770:Gastrointestinal Neoplasms / Q000150:complications*; D016558:Hemostasis, Endoscopic / Q000379:methods*; D006490:Hemostatics / Q000008:administration & dosage*; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D008903:Minerals / Q000008:administration & dosage*; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D006490:Hemostatics; D008903:Minerals; C581750:hemospray
keywords: Hemospray; New endoscopic hemostatic treatment; Upper gastrointestinal cancer; Upper gastrointestinal neoplastic bleeding