title: The effective tool for self-assessment of adherence to treatment in patients with benign prostatic obstruction and overactive bladder symptoms.
abstract: OBJECTIVE
  Study of validity of the Medication Adherence Self-Report Inventory (MASRI) for use in clinical practice to treat patients with benign prostatic obstruction (BPO) accompanied with overactive bladder (OAB) symptoms.
  
  
  METHODS
  During 12 weeks of the randomized study, 452 patients with BPO and OAB symptoms (mean age of 61.3 (12.7)) were studied for adherence to the treatment with Tamsulosin, Solifenacin and Trospium using the MASRI. External monitoring instruments included the Brief Medication Questionnaire (BMQ) and the visual remaining pill count. The state of the prostate gland and the lower urinary tract was monitored using questionnaires I-PSS, OAB Awareness Tool, uroflowmetry and voiding diaries.
  
  
  RESULTS
  Correlation between the percentage of men non-adherent to treatment (MASRI) and the percentage of patients having a belief barrier on the screen of the BMQ was r = 0.89, p ≤0.05, r = 0.92, p ≤0.01, r = 0.85, p ≤0.05, a number of missed doses on the Regimen Screen of the BMQ was r = 0.79; p ≤0.05; r = 0.81; p ≤0.05; r = 0.75, p ≤0.05, a number of non-adherent patients according to the BMQ was r = 0.83 (p ≤0.05), r = 0.88 (p ≤0.05), r = 0.79, p ≤0.05, the results of the pill count were r = 0.65-0.76; p ≤0.05-0.01. These data confirm high validity of the MASRI.
  
  
  CONCLUSIONS
  The MASRI is a valid tool for rapid assessment of adherence to treatment of patients with BPO and OAB receiving Tamsulosin and antimuscarinic drugs and may be recommended for use in clinical practice.
authors.affiliation: a Department of Social Sciences , Far Eastern Federal University , Vladivostok , Russia.
authors.forename: Kirill
authors.initials: K
authors.lastname: Kosilov
authors.affiliation: b Department of Urology , Sity Policlinic 3 , Vladivostok , Russia , and.
authors.forename: Sergey
authors.initials: S
authors.lastname: Loparev
authors.affiliation: a Department of Social Sciences , Far Eastern Federal University , Vladivostok , Russia.
authors.forename: Irina
authors.initials: I
authors.lastname: Kuzina
authors.affiliation: c Department of theory and methodology of adaptive physical training , Far Eastern Federal University , Vladivostok , Russia.
authors.forename: Olga
authors.initials: O
authors.lastname: Shakirova
authors.affiliation: c Department of theory and methodology of adaptive physical training , Far Eastern Federal University , Vladivostok , Russia.
authors.forename: Natalya
authors.initials: N
authors.lastname: Zhuravskaya
authors.affiliation: a Department of Social Sciences , Far Eastern Federal University , Vladivostok , Russia.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Lobodenko
mesh_terms: D000368:Aged; D001561:Benzilates / Q000627:therapeutic use; D059026:Diagnostic Self Evaluation; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D055118:Medication Adherence; D008875:Middle Aged; D018727:Muscarinic Antagonists / Q000627:therapeutic use; D009662:Nortropanes / Q000627:therapeutic use; D011470:Prostatic Hyperplasia / Q000150:complications / Q000188:drug therapy*; D012647:Self-Assessment; D000069464:Solifenacin Succinate / Q000627:therapeutic use; D013449:Sulfonamides / Q000627:therapeutic use; D011795:Surveys and Questionnaires; D000077409:Tamsulosin; D053201:Urinary Bladder, Overactive / Q000150:complications / Q000188:drug therapy*
chemical_list: D001561:Benzilates; D018727:Muscarinic Antagonists; D009662:Nortropanes; D013449:Sulfonamides; C003330:trospium chloride; D000077409:Tamsulosin; D000069464:Solifenacin Succinate
keywords: Medication adherence; Solifenacin; Tamsulosin; Trospium; benign prostatic obstruction; overactive bladder; self-reported questionnaire