title: [Neuromyelitis optica presenting concomitantly with systemic lupus erythematosus: Report of one case].
abstract: Neuromyelitis optica (NMO) is a severe demyelinating disease of the central nervous system, which preferentially attacks the optic nerve and spinal cord. It is associated with antibodies against aquaporin 4. Morbidity and mortality are higher than in multiple sclerosis and its treatment focuses on immunosuppressive drugs. Immunomodulators are contraindicated. We report a previously healthy 35-year-old man, presenting with NMO concomitantly with systemic lupus erythematosus. His evolution was torpid with three outbreaks in the 10 months after the diagnosis, requiring a first-line therapy with methylprednisolone and cyclophosphamide and then a second-line therapy with rituximab.
authors.affiliation: Departamento de Neurología, Hospital Base de Osorno, Osorno, Chile.
authors.forename: Felipe
authors.initials: F
authors.lastname: Suárez H
authors.affiliation: Departamento de Neurología, Hospital Base de Osorno, Osorno, Chile.
authors.forename: Daniela
authors.initials: D
authors.lastname: Urrutia E
authors.affiliation: Universidad Austral de Chile, Chile.
authors.forename: Felipe
authors.initials: F
authors.lastname: Canales P
authors.affiliation: Universidad Austral de Chile, Chile.
authors.forename: Camila
authors.initials: C
authors.lastname: Gutiérrez O
mesh_terms: D000328:Adult; D018501:Antirheumatic Agents / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000188:drug therapy; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D009471:Neuromyelitis Optica / Q000150:complications* / Q000188:drug therapy; D010291:Paresis / Q000150:complications / Q000188:drug therapy; D000069283:Rituximab / Q000627:therapeutic use; D013035:Spasm / Q000150:complications / Q000188:drug therapy
chemical_list: D018501:Antirheumatic Agents; D005938:Glucocorticoids; D000069283:Rituximab; D003520:Cyclophosphamide; D008775:Methylprednisolone