title: [Neuroradiological changes by suppression of tics].
abstract: Tourette's syndrome is characterized by involuntary tics. First choice of treatment has been pharmacological, but recently, behavioural therapy teaching patients to suppress their tics has been introduced. Neuroimaging studies have shown an increased activity in the prefrontal cortex, temporal lobes and caudate nucleus, and a decreased activity in globus pallidus and putamen during inhibition of tics. The activity in the frontal lobes changes with age, probably caused by a lack of compensatory hypertrophy. In order to fully understand the mechanism behind behavioural therapy further studies are needed.
authors.affiliation: sarabohn@hotmail.com.
authors.forename: Sara Bohn
authors.initials: SB
authors.lastname: Larsen
authors.forename: Camilla Birgitte
authors.initials: CB
authors.lastname: Sørensen
authors.forename: Liselotte
authors.initials: L
authors.lastname: Skov
authors.forename: Nanette Mol
authors.initials: NM
authors.lastname: Debes
mesh_terms: D002421:Caudate Nucleus / Q000503:physiopathology; D005917:Globus Pallidus / Q000503:physiopathology; D006179:Gyrus Cinguli / Q000503:physiopathology; D006801:Humans; D007266:Inhibition, Psychological; D008960:Models, Psychological; D059906:Neuroimaging; D010296:Parietal Lobe / Q000503:physiopathology; D017397:Prefrontal Cortex / Q000503:physiopathology; D011699:Putamen / Q000503:physiopathology; D013702:Temporal Lobe / Q000503:physiopathology; D013788:Thalamus / Q000503:physiopathology; D020323:Tics / Q000503:physiopathology*; D005879:Tourette Syndrome / Q000503:physiopathology*