title: Dominating the Negative: How DNMT3A Mutations Contribute to AML Pathogenesis.
abstract: Somatic mutations in DNMT3A are one of the most prevalent genetic abnormalities found in acute myeloid leukemia (AML) patients. A new study by Guryanova et al. sheds mechanistic insight into how the most common DNMT3A variant protein contributes to AML using a combination of mouse genetics and primary patient samples.
authors.affiliation: Division of Oncology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA. Electronic address: grantchallen@wustl.edu.
authors.forename: Grant A
authors.initials: GA
authors.lastname: Challen
mesh_terms: D000818:Animals; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000235:genetics*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D051379:Mice; D009154:Mutation
chemical_list: D004248:DNA (Cytosine-5-)-Methyltransferases