title: Role of proteasomes in non-specific immune response of marine annelids.
abstract: We investigated functioning of proteasomes and chaperones in Arenicola marina coelomocytes in conditions of lipopolysaccharide-induced inflammation. We observed the increase of chymotrypsin-like proteasome activity in coelomocytes 1 h after induction. Amount of proteasome subunits alpha- and beta-5 types increased as well. We also detected appearance of a new form of Hsp70 chaperone in infected coelomocytes. Our results allow us to consider the changes in proteasome structure and induction of chaperones as principle mechanisms in stress adaptation and defensive reactions development in annelids.
authors.affiliation: Koltzov Institute of Developmental Biology of Russian Academy of Sciences, Moscow, Russia.
authors.forename: M V
authors.initials: MV
authors.lastname: Stanovova
authors.affiliation: Koltzov Institute of Developmental Biology of Russian Academy of Sciences, Moscow, Russia.
authors.forename: P A
authors.initials: PA
authors.lastname: Erokhov
authors.affiliation: Koltzov Institute of Developmental Biology of Russian Academy of Sciences, Moscow, Russia.
authors.forename: N G
authors.initials: NG
authors.lastname: Gornostaev
authors.affiliation: Koltzov Institute of Developmental Biology of Russian Academy of Sciences, Moscow, Russia.
authors.forename: V S
authors.initials: VS
authors.lastname: Mikhailov
authors.affiliation: Koltzov Institute of Developmental Biology of Russian Academy of Sciences, Moscow, Russia. yulial@bk.ru.
authors.forename: Yu V
authors.initials: YV
authors.lastname: Lyupina
mesh_terms: D000818:Animals; D015153:Blotting, Western; D004586:Electrophoresis; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism; D008070:Lipopolysaccharides; D011077:Polychaeta / Q000201:enzymology* / Q000276:immunology*; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*
chemical_list: D018840:HSP70 Heat-Shock Proteins; D008070:Lipopolysaccharides; D046988:Proteasome Endopeptidase Complex