title: The Early Effect of Carotid Artery Stenting on Antioxidant Capacity and Oxidative Stress in Patients with Carotid Artery Stenosis.
abstract: The treatment of carotid artery stenosis is associated with the risk of complications, which may include stroke after carotid artery stenting (CAS) and myocardial infarction after carotid endarterectomy (CEA). The imbalance between prooxidative mechanisms and antioxidant capacity creates a milieu of factors, which may increase the risk of complications after endovascular procedures. We have examined 43 consecutive patients with carotid artery stenosis. Sera were analyzed for the activity of paraoxonase (PON) and arylesterase (ARE), sulfhydryl groups (SG), malondialdehyde (MDA), and conjugated dienes (CD) concentrations by means of spectrophotometric methods before and next day after CAS. We have found lowered PON (P= 0.0032), increase in ARE activity (P= 0.0058), and decrease in sulfhydryl groups concentration (P= 0.0267). No effect on absolute MDA and CD concentrations was observed. The degree of carotid artery stenosis correlated negatively with PON/ARE ratio after CAS (rS= -0.507,P= 0.0268). To conclude, CAS influences both enzymatic (differently, PON and ARE activity) and nonenzymatic antioxidant defense. Females are more susceptible to lipid peroxidation after CAS. PON/ARE ratio after CAS correlated with the degree of carotid artery stenosis. The changes (deltas) in ARE activity, SG, and MDA concentrations correlated with the severity of neurological deficit and disability.
authors.affiliation: Department of Neurochemistry and Neuropathology, Poznan University of Medical Sciences, Przybyszewskiego Str. 49, 60-355 Poznan, Poland.
authors.forename: Slawomir
authors.identifier: 0000-0002-5602-4306
authors.initials: S
authors.lastname: Michalak
authors.affiliation: Department of Neurology, Poznan University of Medical Sciences, Przybyszewskiego Str. 49, 60-355 Poznan, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Ambrosius
authors.affiliation: Chair and Department of Laboratory Diagnostics, Poznan University of Medical Sciences, Szamarzewskiego Str. 82/84, 60-569 Poznan, Poland.
authors.forename: Ewa
authors.identifier: 0000-0002-4101-7656
authors.initials: E
authors.lastname: Wysocka
authors.affiliation: Department of Cardiology-Intensive Therapy, Poznan University of Medical Sciences, Przybyszewskiego Str. 49, 60-355 Poznan, Poland.
authors.forename: Mieczyslaw
authors.initials: M
authors.lastname: Dziarmaga
authors.affiliation: Department of General and Interventional Radiology, Poznan University of Medical Sciences, Dluga Str. 1/2, 61-848 Poznan, Poland.
authors.forename: Robert
authors.initials: R
authors.lastname: Juszkat
authors.affiliation: Department of Cardiology-Intensive Therapy, Poznan University of Medical Sciences, Przybyszewskiego Str. 49, 60-355 Poznan, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Wykretowicz
authors.affiliation: Department of Neurology, Poznan University of Medical Sciences, Przybyszewskiego Str. 49, 60-355 Poznan, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Kozubski
mesh_terms: D000975:Antioxidants / Q000378:metabolism*; D043303:Aryldialkylphosphatase / Q000378:metabolism; D002265:Carboxylic Ester Hydrolases / Q000378:metabolism; D002339:Carotid Arteries / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology*; D016893:Carotid Stenosis / Q000201:enzymology / Q000473:pathology*; D015331:Cohort Studies; D003710:Demography; D005260:Female; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008875:Middle Aged; D018384:Oxidative Stress; D011090:Polyenes / Q000378:metabolism; D015607:Stents
chemical_list: D000975:Antioxidants; D011090:Polyenes; D008315:Malondialdehyde; D002265:Carboxylic Ester Hydrolases; C019734:arylesterase; D043303:Aryldialkylphosphatase