title: Recent Advances in Application of Poly-Epsilon-Caprolactone and its Derivative Copolymers for Controlled Release of Anti-Tumor Drugs.
abstract: BACKGROUND
  Due to their excellent biocompatibility and biodegradability, poly-epsiloncaprolactone and its derivative copolymers have been extensively studied as drug carriers in pharmaceutical and medical fields, especially for controlled release of anti-tumor drugs. Poly-epsiloncaprolactone based drug delivery systems lead to major advantages including uniform drug distribution, long term of degradation and drug release process, non-toxic in nature and cyto-compatible with body tissues. Approved by US Food and Drug Administration, poly-epsilon-caprolactone provides a promising platform for design and fabrication of anti-tumor drug delivery systems with controllable drug release behaviors.
  
  
  METHODS
  This mini-review focused on the recent progress in application of poly-epsiloncaprolactone based materials for controlled release of cancer therapy drugs. A careful search was performed on web of science, mainly focused on the related papers published from 2013 to 2016.
  
  
  CONCLUSIONS
  Recent advances in applying poly-epsilon-caprolactone for controlled delivery and targeting release of chemical anti-tumor drugs were summarized in this mini-review. Benefited from the efforts of scientists all over the world, various chemotherapeutic drug delivery systems based on different formulations of poly-epsilon-caprolactone related materials have been evaluated. It has been widely recognized that the introduction of of poly-epsilon-caprolactone components into drug delivery systems would increase drug loading capacity, decrease leakage, prolong releasing period and result in controllable releasing rate. Especially with the development of environment-responsive delivery systems (pH-, thermo-, magnetic field- and light-responsive drug carriers), enhanced tumor cell targeting potential, as well as decreased systemic toxicity would be realized.
authors.affiliation: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022. China.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Sun
authors.affiliation: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022. China.
authors.forename: Ranglong
authors.initials: R
authors.lastname: Duan
authors.affiliation: Tumor Hospital of Jilin Province, Changchun, 130012. China.
authors.forename: Dejun
authors.initials: D
authors.lastname: Xing
authors.affiliation: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022. China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Pang
authors.affiliation: Tumor Hospital of Jilin Province, Changchun 130012. China.
authors.forename: Zhiying
authors.initials: Z
authors.lastname: Li
authors.affiliation: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022. China.
authors.forename: Xuesi
authors.initials: X
authors.lastname: Chen
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002208:Caproates / Q000008:administration & dosage*; D003692:Delayed-Action Preparations; D020100:Hydrogels; D007783:Lactones / Q000008:administration & dosage*; D011108:Polymers / Q000008:administration & dosage*
chemical_list: D000970:Antineoplastic Agents; D002208:Caproates; D003692:Delayed-Action Preparations; D020100:Hydrogels; D007783:Lactones; D011108:Polymers; C121056:caprolactone
keywords: Poly-epsilon-caprolactone; anti-tumor; biodegradable; controlled release; drug delivery; targeting