title: Metal-Ion-Mediated Supramolecular Assembly of C3-Peptides.
abstract: An investigation on a supramolecular assembly of C3-molecules benzene-1,3,5-tricarboxamides carrying tetrapeptide Gly-Ala-Gly-Ala pendants promoted by hydrogen bonding and metal ion coordination is described. A Gly-Ala peptide sequence was selected as it is the most abundant repeating unit in silkworm silk, and known to form β-sheets through efficient intermolecular hydrogen bonds. These C3-peptides formed long helical fibers in solvents mainly owing to strong hydrogen bonding. However, in the presence of divalent metal ions, chirality of these helical fibers was enhanced through metal coordination and could be transformed into nanospheres with an excess amount of the ions. Different metal ions show different tendencies to mediate the supramolecular chirality, which can even be inverted according to coordination differences.
authors.affiliation: Department of Polymer Materials, Shanghai University, Nanchen Street 333, Shanghai, 200444, P.R. China.|School of Pharmacy, Jining Medical University, Rizhao, 276800, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Polymer Materials, Shanghai University, Nanchen Street 333, Shanghai, 200444, P.R. China.
authors.forename: Feng
authors.initials: F
authors.lastname: Shao
authors.affiliation: Department of Polymer Materials, Shanghai University, Nanchen Street 333, Shanghai, 200444, P.R. China.
authors.forename: Wen
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Polymer Materials, Shanghai University, Nanchen Street 333, Shanghai, 200444, P.R. China.
authors.forename: Jiatao
authors.initials: J
authors.lastname: Yan
authors.affiliation: Department of Polymer Materials, Shanghai University, Nanchen Street 333, Shanghai, 200444, P.R. China.
authors.forename: Kun
authors.initials: K
authors.lastname: Liu
authors.affiliation: Department of Polymer Materials, Shanghai University, Nanchen Street 333, Shanghai, 200444, P.R. China.
authors.forename: Pei
authors.initials: P
authors.lastname: Tao
authors.affiliation: Department of Polymer Materials, Shanghai University, Nanchen Street 333, Shanghai, 200444, P.R. China.
authors.forename: Toshio
authors.initials: T
authors.lastname: Masuda
authors.affiliation: Department of Polymer Materials, Shanghai University, Nanchen Street 333, Shanghai, 200444, P.R. China.
authors.forename: Afang
authors.initials: A
authors.lastname: Zhang
mesh_terms: D001549:Benzamides / Q000138:chemical synthesis* / Q000737:chemistry; D007477:Ions / Q000737:chemistry; D046911:Macromolecular Substances / Q000138:chemical synthesis / Q000737:chemistry; D008673:Metals, Alkaline Earth / Q000737:chemistry*; D019216:Metals, Heavy / Q000737:chemistry*; D015394:Molecular Structure; D009842:Oligopeptides / Q000737:chemistry*
chemical_list: D001549:Benzamides; D007477:Ions; D046911:Macromolecular Substances; D008673:Metals, Alkaline Earth; D019216:Metals, Heavy; D009842:Oligopeptides; C558700:benzene-1,3,5-tricarboxamide
keywords: chirality; hydrogen bonds; metal-ion coordination; peptides; supramolecular assembly