title: A Review of Recent Advances in Neuroprotective Potential of 3-N-Butylphthalide and Its Derivatives.
abstract: The research of alternative treatment for ischemic stroke and degenerative diseases has always been a priority in neurology. 3-N-Butylphthalide (NBP), a family of compounds initially isolated from the seeds ofApium graveolensLinn., has shown significant neuroprotective effects. Previous extensive studies have demonstrated that NBP promotes a better poststroke outcome and exerts a multitargeted action on several mechanisms, from oxidative stress to mitochondrial dysfunction to apoptosis to inflammation. Additionally, recent findings on several neurological disorders have shown that NBP's beneficial effects extend beyond the management of stroke. However, despite the increasing number of studies toward a better understanding and the rapid advances made in therapeutic options, to date, dl-3-N-butylphthalide, a synthetic variation of l-3-N-butylphthalide, remains the only clinically approved anti-ischemic agent in China, stressing the difficulties for a viable and effective transition from experimental to clinical practice. Events indicate that NBP, due to its multitargeted effect and the adaptability of its basic structure, can be an important game changer and a precursor to a whole new therapeutic approach to several neurological conditions. The present review discusses recent advances pertaining to the neuroprotective mechanisms of NBP-derived compounds and the possibility of their clinical implementation in the management of various neurological conditions.
authors.affiliation: Department of Neurology, The Southeast University Affiliated Zhong Da Hospital, No. 87 Dingjiaqiao, Nanjing, Jiangsu Province 210009, China.
authors.forename: Idriss Ali
authors.identifier: 0000-0002-0576-7679
authors.initials: IA
authors.lastname: Abdoulaye
authors.affiliation: Department of Neurology, The Southeast University Affiliated Zhong Da Hospital, No. 87 Dingjiaqiao, Nanjing, Jiangsu Province 210009, China.
authors.forename: Yi Jing
authors.identifier: 0000-0002-5894-099X
authors.initials: YJ
authors.lastname: Guo
mesh_terms: D000077102:Apium / Q000737:chemistry; D017209:Apoptosis / Q000187:drug effects; D001572:Benzofurans / Q000627:therapeutic use*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy* / Q000473:pathology; D009422:Nervous System Diseases / Q000188:drug therapy* / Q000473:pathology; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D018384:Oxidative Stress / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D001572:Benzofurans; D018696:Neuroprotective Agents; D010936:Plant Extracts; C027125:3-n-butylphthalide