title: Neuromusculoskeletal model self-calibration for on-line sequential bayesian moment estimation.
abstract: Neuromusculoskeletal models involve many subject-specific physiological parameters that need to be adjusted to adequately represent muscle properties. Traditionally, neuromusculoskeletal models have been calibrated with a forward-inverse dynamic optimization which is time-consuming and unfeasible for rehabilitation therapy. Non self-calibration algorithms have been applied to these models. To the best of our knowledge, the algorithm proposed in this work is the first on-line calibration algorithm for muscle models that allows a generic model to be adjusted to different subjects in a few steps.
  
  
  
  In this paper we propose a reformulation of the traditional muscle models that is able to sequentially estimate the kinetics (net joint moments), and also its full self-calibration (subject-specific internal parameters of the muscle from a set of arbitrary uncalibrated data), based on the unscented Kalman filter. The nonlinearity of the model as well as its calibration problem have obliged us to adopt the sum of Gaussians filter suitable for nonlinear systems.
  
  
  
  This sequential Bayesian self-calibration algorithm achieves a complete muscle model calibration using as input only a dataset of uncalibrated sEMG and kinematics data. The approach is validated experimentally using data from the upper limbs of 21 subjects.
  
  
  
  The results show the feasibility of neuromusculoskeletal model self-calibration. This study will contribute to a better understanding of the generalization of muscle models for subject-specific rehabilitation therapies. Moreover, this work is very promising for rehabilitation devices such as electromyography-driven exoskeletons or prostheses.
authors.forename: Diana R
authors.initials: DR
authors.lastname: Bueno
authors.forename: L
authors.initials: L
authors.lastname: Montano
mesh_terms: D001499:Bayes Theorem; D003198:Computer Simulation; D004551:Elbow Joint / Q000502:physiology*; D004576:Electromyography / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008959:Models, Neurological; D009119:Muscle Contraction / Q000502:physiology*; D018482:Muscle, Skeletal / Q000502:physiology*; D010363:Pattern Recognition, Automated / Q000379:methods; D016059:Range of Motion, Articular / Q000502:physiology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013314:Stress, Mechanical; D019415:Torque; D055815:Young Adult