title: Objection to postoperative radiation therapy in breast cancer with one to three lymph nodes involvements.
abstract: My arguments regarding postmastectomy radiotherapy (PMRT) for this case are based on the following 4 reasons: (1) high rate of local recurrence in the no PMRT group in the Early Breast Cancer Trialists' Collaborative Group meta-analysis on which the present guideline is based, (2) stage migration by sentinel node biopsy, (3) possible adverse events of radiotherapy, and (4) problems on extrapolation of data from western countries.
authors.affiliation: Department of Breast Oncology and Surgery, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku, Tokyo, 160-0023, Japan. tishik55@gmail.com.
authors.forename: Takashi
authors.initials: T
authors.lastname: Ishikawa
authors.affiliation: Department of Breast Oncology and Surgery, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku, Tokyo, 160-0023, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kaise
authors.affiliation: Department of Breast Oncology and Surgery, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku, Tokyo, 160-0023, Japan.
authors.forename: Kimito
authors.initials: K
authors.lastname: Yamada
authors.affiliation: Department of Breast Oncology and Surgery, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku, Tokyo, 160-0023, Japan.
authors.forename: Mari
authors.initials: M
authors.lastname: Hosonaga
authors.affiliation: Department of Breast Surgery, Yokohama Rosai Hospital, 3211 Kozukuecho, Kohokuku, Yokohama, 222-0036, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Chishima
authors.affiliation: Department of Breast and Thyroid Surgery, Yokohama City University Medical Center, Yokohama, 232-0024, Japan.
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Narui
authors.affiliation: Department of Breast and Thyroid Surgery, Yokohama City University Medical Center, Yokohama, 232-0024, Japan.
authors.forename: Akimitsu
authors.initials: A
authors.lastname: Yamada
authors.affiliation: Department of Clinical Oncology and Gastrointestinal Surgery, School of Medicine, Yokohama City University, Yokohama, 232-0024, Japan.
authors.forename: Sadatoshi
authors.initials: S
authors.lastname: Sugae
authors.affiliation: Department of Clinical Oncology and Gastrointestinal Surgery, School of Medicine, Yokohama City University, Yokohama, 232-0024, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Ichikawa
authors.affiliation: Department of Gastroenterology, Yokohama City University Medical Center, Yokohama, 232-0024, Japan.
authors.forename: Mitsuyoshi
authors.initials: M
authors.lastname: Ota
authors.forename: Miwako
authors.initials: M
authors.lastname: Nozaki
authors.affiliation: Department of Radiology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku, Tokyo, 160-0023, Japan.
authors.forename: Ryuji
authors.initials: R
authors.lastname: Mikami
authors.affiliation: Department of Radiology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku, Tokyo, 160-0023, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Tokuuye
mesh_terms: D001943:Breast Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008408:Mastectomy; D015201:Meta-Analysis as Topic; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D011182:Postoperative Care; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D021701:Sentinel Lymph Node Biopsy
keywords: Breast cancer; Clinical trial; Postoperative radiation therapy