title: Gliomas: New Perspectives in Diagnosis, Treatment and Prognosis.
abstract: Gliomas are central nervous system tumors originated from glial cells, whose incidence and mortality is expected to rise in coming years, especially in developing countries. Diagnosis and classification of gliomas have largely relied on tumor histopathologic features that provide limited information regarding response to therapy or prognosis. Current treatment of gliomas is surgery combined with chemotherapy and/or radiotherapy. However, many tumors show a high resistance to these interventions, and recurrences are frequent since conventional therapies do not take into account the unique molecular features of different subtypes of glioma. Molecular genetics provide new insights in classifying gliomas and predicting response to therapy that can range from conventional treatments to new revolutionary therapeutic approaches. This article offers a review of the intracellular signaling pathways involved in carcinogenesis of gliomas, as well as a description of new tools for their diagnosis, prognosis, and treatment with a target-oriented approach.
authors.affiliation: Faculty of Medicine, Universidad de La Sabana, Chia, Colombia.|Neurosurgery Unit, Fundacion Santafe de Bogota, Bogota, Colombia.
authors.forename: Kemel A
authors.initials: KA
authors.lastname: Ghotme
authors.affiliation: Departamento de Nutrición y Bioquímica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá D.C., Colombia.|Instituto de Ciencias Biomedicas, Universidad Autonoma de Chile, Santiago, Chile.
authors.forename: George E
authors.initials: GE
authors.lastname: Barreto
authors.affiliation: Universidad San Sebastian, Lientur, Concepcion, Chile.
authors.forename: Valentina
authors.initials: V
authors.lastname: Echeverria
authors.affiliation: Departamento de Nutricion y Bioquimica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogota D.C., Colombia.
authors.forename: Janneth
authors.initials: J
authors.lastname: Gonzalez
authors.affiliation: Universidad de la Sabana, Chia, Colombia.
authors.forename: Rosa H
authors.initials: RH
authors.lastname: Bustos
authors.affiliation: Universidad de la Sabana, Chia, Colombia.|Fundacion de NeuroRegeneracion de Colombia, Bogota, Colombia.
authors.forename: Magdy
authors.initials: M
authors.lastname: Sanchez
authors.affiliation: Department of Psychiatry, Wroclaw Medical University, Wroclaw, Poland.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Leszek
authors.affiliation: Department of Biochemistry and Bioinformatics, Institute of Science, GITAM University, Viskhapatnam, A.P., India.
authors.forename: Nagendra Sastry
authors.initials: NS
authors.lastname: Yarla
authors.affiliation: Fundacion de NeuroRegeneracion de Colombia, Bogota, Colombia.
authors.forename: Rosa Margarita
authors.initials: RM
authors.lastname: Gomez
authors.affiliation: Institute of Pharmacy and Translational Medicine, Sechenov First Moscow State Medical University, 2-4 Bolshaya Pirogovskaya St., 119991 Moscow, Russian Federation.
authors.forename: Vadim V
authors.initials: VV
authors.lastname: Tarasov
authors.affiliation: King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.
authors.forename: Ghulam Md
authors.initials: GM
authors.lastname: Ashraf
authors.affiliation: GALLY International Biomedical Research Consulting LLC., 7733 Louis Pasteur Drive, #330, San Antonio, TX, 78229, United States.|School of Health Science and Healthcare Administration, University of Atlanta, E. Johns Crossing, #175, Johns Creek, GA, 30097, USA.|Institute of Physiologically Active Compounds Russian Academy of Sciences, Chernogolovka, 142432, Russi.
authors.forename: Gjumrakch
authors.initials: G
authors.lastname: Aliev
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016543:Central Nervous System Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D005910:Glioma / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D006801:Humans; D015398:Signal Transduction / Q000187:drug effects / Q000235:genetics
keywords: Biomarkers; Genotype; Glioma; Gliomagenesis; Phenotype; Prognosis; Signaling Pathways; Treatment