title: Sinonasal Delivery of Resveratrol via Mucoadhesive Nanostructured Microparticles in a Nasal Polyp Mouse Model.
abstract: Resveratrol (RSV) has been shown to effectively suppress chronic rhinosinusitis with nasal polyps in a mouse model; however, when locally administered to the sinonasal cavity, bolus RSV is limited by low drug bioavailability owing to its low aqueous solubility and relatively rapid clearance from the administration site. To address this limitation, we propose mucoadhesive nanostructured microparticles (PLGA/PEG NM) as a potential carrier for the sinonasal delivery of RSV. In this study, PLGA/PEG NM released RSV in a sustained manner. Owing to the enlarged specific surface area of the nanostructures, PLGA/PEG NM had synergistically enhanced mucoadhesiveness and thus showed improved in vivo retention properties in the sinonasal cavity. Therefore, when tested in a mouse nasal polyp model, PLGA/PEG NM mitigated polyp formation and restored epithelial integrity better than the control treatments. The therapeutic effect was similar at half the dose of PLGA/PEG NM, suggesting improved local bioavailability of RSV in the sinonasal cavity.
authors.affiliation: Obstructive Upper airway Research (OUaR) Laboratory, Department of Pharmacology, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea.|Department of Biomedical Science, Seoul National University Graduate School, Seoul, 03080, Republic of Korea.|Cancer Research Institute, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea.
authors.forename: Mingyu
authors.initials: M
authors.lastname: Lee
authors.affiliation: Institute of Medical &Biological Engineering, Medical Research Center, Seoul National University, Seoul, 03080, Republic of Korea.
authors.forename: Chun Gwon
authors.initials: CG
authors.lastname: Park
authors.affiliation: Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University, Seoul, 08826, Republic of Korea.
authors.forename: Beom Kang
authors.initials: BK
authors.lastname: Huh
authors.affiliation: Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University, Seoul, 08826, Republic of Korea.
authors.forename: Se-Na
authors.initials: SN
authors.lastname: Kim
authors.affiliation: Institute of Medical &Biological Engineering, Medical Research Center, Seoul National University, Seoul, 03080, Republic of Korea.
authors.forename: Seung Ho
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Obstructive Upper airway Research (OUaR) Laboratory, Department of Pharmacology, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea.
authors.forename: Roza
authors.initials: R
authors.lastname: Khalmuratova
authors.affiliation: Obstructive Upper airway Research (OUaR) Laboratory, Department of Pharmacology, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea.|Department of Biomedical Science, Seoul National University Graduate School, Seoul, 03080, Republic of Korea.|Cancer Research Institute, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea.|Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea.
authors.forename: Jong-Wan
authors.initials: JW
authors.lastname: Park
authors.affiliation: Obstructive Upper airway Research (OUaR) Laboratory, Department of Pharmacology, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea.|Department of Biomedical Science, Seoul National University Graduate School, Seoul, 03080, Republic of Korea.|Cancer Research Institute, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea.|Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea.|Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul, 03080, Republic of Korea.
authors.forename: Hyun-Woo
authors.initials: HW
authors.lastname: Shin
authors.affiliation: Institute of Medical &Biological Engineering, Medical Research Center, Seoul National University, Seoul, 03080, Republic of Korea.|Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University, Seoul, 08826, Republic of Korea.|Department of Biomedical Engineering, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea.
authors.forename: Young Bin
authors.initials: YB
authors.lastname: Choy
mesh_terms: D000269:Adhesives / Q000493:pharmacokinetics; D000281:Administration, Intranasal; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000493:pharmacokinetics* / Q000633:toxicity; D004337:Drug Carriers; D008297:Male; D008807:Mice, Inbred BALB C; D053758:Nanoparticles; D009297:Nasal Mucosa / Q000187:drug effects; D009298:Nasal Polyps / Q000188:drug therapy*; D000077185:Resveratrol; D012220:Rhinitis / Q000188:drug therapy; D012852:Sinusitis / Q000188:drug therapy; D013267:Stilbenes / Q000008:administration & dosage* / Q000493:pharmacokinetics* / Q000633:toxicity
chemical_list: D000269:Adhesives; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; D013267:Stilbenes; D000077185:Resveratrol