title: Radiographic capsule-based system for non-cathartic colorectal cancer screening.
abstract: Many patients are reluctant to undergo optical colonoscopy for colorectal cancer screening. The Check-Cap colon imaging system is a non-invasive test that comprises an ingestible imaging capsule that emits and detects ultra-low-dose radiation. The capsule generates a 3D reconstruction of the colonic lumen for detection of polyps and cancer. Preliminary preclinical and clinical testing has demonstrated safety and feasibility. Mean radiation dose is estimated at 0.04 mSv. In conclusion, we describe a novel capsule-based, patient-friendly colorectal test that holds potential for non-invasive screening.
authors.affiliation: Check-Cap, Mount Carmel, Israel.
authors.forename: Yoav
authors.initials: Y
authors.lastname: Kimchy
authors.affiliation: Check-Cap, Mount Carmel, Israel.
authors.forename: Ronen
authors.initials: R
authors.lastname: Lifshitz
authors.affiliation: Check-Cap, Mount Carmel, Israel.
authors.forename: Shlomo
authors.initials: S
authors.lastname: Lewkowitz
authors.affiliation: Politecnico di Milano, Milan, Italy.
authors.forename: Guiseppe
authors.initials: G
authors.lastname: Bertuccio
authors.affiliation: Tel Aviv Sourasky Medical Center; Tel Aviv University School of Medicine, Tel Aviv, Israel.
authors.forename: Nadir
authors.initials: N
authors.lastname: Arber
authors.affiliation: Tel Aviv Sourasky Medical Center; Tel Aviv University School of Medicine, Tel Aviv, Israel.
authors.forename: Nathan
authors.initials: N
authors.lastname: Gluck
authors.affiliation: Department of Radiology, University of Wisconsin School of Medicine & Public Health, E3/311 Clinical Science Center, 600 Highland Ave., Madison, WI, 53792-3252, USA. ppickhardt2@uwhealth.org.
authors.forename: Perry J
authors.initials: PJ
authors.lastname: Pickhardt
mesh_terms: D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000000981:diagnostic imaging*; D003287:Contrast Media / Q000008:administration & dosage; D055088:Early Detection of Cancer; D004867:Equipment Design; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D008297:Male; D008403:Mass Screening / Q000295:instrumentation*; D008875:Middle Aged; D011829:Radiation Dosage; D011846:Radio Waves; D011857:Radiographic Image Interpretation, Computer-Assisted; D011859:Radiography / Q000295:instrumentation*
chemical_list: D003287:Contrast Media
keywords: Colon capsule; Colorectal cancer; Colorectal polyps; Screening