title: [Buschke-Lowenstein tumors].
abstract: BACKGROUND
  A giant condyloma acuminatum which shows destructive growth but lacking invasion is designated as a Buschke-Lowenstein tumor (BLT).
  
  
  OBJECTIVE
  Classification of the BLT and therapeutic guidelines are provided.
  
  
  METHODS
  A MEDLINE literature search from 2006-2016 was performed.
  
  
  RESULTS
  Induction through low-risk mucosotropic human papillomavirus (HPV) infection separates BLT from verrucous carcinoma. In the last 10 years, slightly more than 100 new cases have been described. Invasion as a true sign of malignancy was described in 12% of cases. HIV infection was observed in 14%. As invasion often occurs only focally and may only be detected after complete resection, BLT must be treated and considered as a low grade in situ epithelial cancer that evolves from condylomata acuminata. Diagnosis is confirmed by HPV detection and typical histology. CT scans are recommended to rule out deeper invasion. Organ preservation surgery remains the recommended therapy.
  
  
  CONCLUSIONS
  Buschke-Lowenstein tumors represent low grade epithelial in situ carcinomas which evolved from condylomata acuminata. Focal invasion is frequent but metastases occur only rarely. Organ preservation surgery is recommended.
authors.affiliation: Anästhesiologie und operative Intensivmedizin, Luisenhospital Aachen, Boxgraben 99, 52064, Aachen, Deutschland.
authors.forename: M
authors.initials: M
authors.lastname: Sporkert
authors.affiliation: Hautklinik, Universitätsklinikum der RWTH-Aachen, Pauwelsstr. 30, 52074, Aachen, Deutschland. Albert.ruebben@post.rwth-aachen.de.
authors.forename: A
authors.initials: A
authors.lastname: Rübben
mesh_terms: D062688:Buschke-Lowenstein Tumor / Q000175:diagnosis / Q000453:epidemiology* / Q000601:surgery*; D062109:Dermatologic Surgical Procedures / Q000379:methods / Q000706:statistics & numerical data*; D003937:Diagnosis, Differential; D019317:Evidence-Based Medicine; D006801:Humans; D059351:Organ Sparing Treatments / Q000706:statistics & numerical data*; D027383:Papillomaviridae / Q000302:isolation & purification*; D015995:Prevalence; D012307:Risk Factors; D016896:Treatment Outcome
keywords: Condylomata acuminata; Giant condyloma acuminatum; Human papillomavirus; Malignancy; Verrucous carcinoma