title: Interleukin-6-174G/C Polymorphism Contributes to Periodontitis Susceptibility: An Updated Meta-Analysis of 21 Case-Control Studies.
abstract: Introduction. Chronic Periodontitis (CP) is suggested to be related to gene variations. Present study aims to quantitatively estimate the association between interleukin-6- (IL-6-) 174G/C polymorphism and CP susceptibility.Materials and Methods. Pubmed, Embase, and Web of Science were searched up to May 2016. The meta-analyses were performed using STATA 12.0.Results. 21 studies were yielded. Significant associations were found under heterozygote comparison and dominant model in studies fulfilling HWE (GC versus GG: OR = 0.690, 95% CI = 0.560-0.849,P= 0.000; CC + GC versus GG: OR = 0.690, 95% CI = 0.568-0.838,P< 0.001); significant associations were found under heterozygote comparison and dominant model in Caucasian studies fulfilling HWE (GC versus GG: OR = 0.752, 95% CI = 0.577-0.980,P= 0.035; CC + GC versus GG: OR = 0.737, 95% CI = 0.576-0.944,P= 0.016); significant associations were found under allele comparison, heterozygote comparison, and dominant model in Brazilian population (C versus G: OR = 0.648, 95% CI = 0.497-0.845,P= 0.001; GC versus GG: OR = 0.621, 95% CI = 0.441-0.876,P= 0.007; CC + GC versus GG: OR = 0.649, 95% CI = 0.470-0.896,P= 0.009).Conclusion. IL-6 174 polymorphism is associated with CP susceptibility. In Brazilian and Caucasian population, IL-6 174 GG genotype plays as a risk factor to CP.
authors.affiliation: State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China.
authors.forename: Junfei
authors.identifier: 0000-0003-3679-5733
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Institute of Stomatology of Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, China.
authors.forename: Bin
authors.identifier: 0000-0001-5278-0182
authors.initials: B
authors.lastname: Guo
authors.affiliation: State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China.
authors.forename: Min
authors.initials: M
authors.lastname: Fu
authors.affiliation: State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China.
authors.forename: Wushuang
authors.initials: W
authors.lastname: Guo
authors.affiliation: State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China.
authors.forename: Yifang
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China.
authors.forename: He
authors.initials: H
authors.lastname: Yuan
authors.affiliation: West China Medical School, Sichuan University, Chengdu 610041, China.
authors.forename: Suhan
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
authors.forename: Haiyang
authors.identifier: 0000-0002-3388-6106
authors.initials: H
authors.lastname: Yu
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D055113:Chronic Periodontitis / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6