title: Development of a Multifunctional Needle for Percutaneous Heart Biopsy and Cell Therapy. A Technical Note.
abstract: Validation of transendocardial injection as a method for delivering therapeutic agents to the diseased heart is increasing. Puncture heart biopsies should re-emerge as a possible alternative method to allow access to the myocardium and implantable biomaterial for cell therapy. Therefore, this work aims to present a percutaneous puncture device for biopsy and intramyocardial biomaterial injection, standardize the technique and attest to the safety of the method. The adaptation consists of creating myocardial microlesions that allow for better fixation of stem cells. The objective of this technical note covers only the development of the needle and the histological quality of the biopsies. It has not been used in humans yet.
authors.affiliation: Department of Surgery and Anatomy, Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (FMRP-USP), Ribeirão Preto, SP, Brazil.
authors.forename: Nathan Valle
authors.initials: NV
authors.lastname: Soubihe
authors.affiliation: Department of Surgery and Anatomy, Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (FMRP-USP), Ribeirão Preto, SP, Brazil.
authors.forename: Agnes Afrodite S
authors.initials: AA
authors.lastname: Albuquerque
authors.affiliation: Department of Surgery and Anatomy, Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (FMRP-USP), Ribeirão Preto, SP, Brazil.
authors.forename: Livia
authors.initials: L
authors.lastname: Arcêncio
authors.affiliation: Department of Surgery and Anatomy, Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (FMRP-USP), Ribeirão Preto, SP, Brazil.
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Thomazini
authors.affiliation: Department of Internal Medicine, Faculdade de Medicina de Ribeirao Preto da Universidade de São Paulo (FMRP-USP), Ribeirão Preto, SP, Brazil.
authors.forename: Andre
authors.initials: A
authors.lastname: Schmidt
authors.affiliation: Department of Surgery and Anatomy, Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (FMRP-USP), Ribeirão Preto, SP, Brazil.
authors.forename: Paulo Roberto B
authors.initials: PR
authors.lastname: Evora
mesh_terms: D000818:Animals; D001707:Biopsy, Needle / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D009206:Myocardium; D009339:Needles; D015203:Reproducibility of Results; D033581:Stem Cell Transplantation / Q000295:instrumentation / Q000379:methods*