title: High temperature requirement A1 and fibronectin: two possible players in placental tissue remodelling.
abstract: High temperature requirement A1 (HtrA1) is a secreted protease involved in placental development. Fibronectin (FN) is involved in important process such as wound healing, cell adhesion and spreading, growth, migration, and differentiation. The purpose of this study was to analyse the expression patterns of HtrA1 in relationship to FN and to the key growth zones of placenta such as mesenchymal villi as well as cell islands and cell columns. We demonstrated that FN and HtrA1 are localized in the placental key growth zones suggesting a pivotal role in maintaining the balance among the molecules involved in the placental development and differentiation.
authors.affiliation: Polytechnic University of Marche, Department of Experimental and Clinical Medicine. g.tossetta@univpm.it.
authors.forename: G
authors.initials: G
authors.lastname: Tossetta
authors.forename: C
authors.initials: C
authors.lastname: Avellini
authors.forename: C
authors.initials: C
authors.lastname: Licini
authors.forename: S R
authors.initials: SR
authors.lastname: Giannubilo
authors.forename: M
authors.initials: M
authors.lastname: Castellucci
authors.forename: D
authors.initials: D
authors.lastname: Marzioni
mesh_terms: D002824:Chorionic Villi / Q000378:metabolism*; D005260:Female; D005353:Fibronectins / Q000096:biosynthesis*; D005786:Gene Expression Regulation / Q000502:physiology*; D000074289:High-Temperature Requirement A Serine Peptidase 1; D006801:Humans; D011247:Pregnancy; D012697:Serine Endopeptidases / Q000096:biosynthesis*
chemical_list: D005353:Fibronectins; D000074289:High-Temperature Requirement A Serine Peptidase 1; C474012:HTRA1 protein, human; D012697:Serine Endopeptidases