title: Static magnetic field reduces blood pressure short-term variability and enhances baro-receptor reflex sensitivity in spontaneously hypertensive rats.
abstract: It has been shown that chronic exposure of young spontaneously hypertensive rats (SHR) to static magnetic field (SMF) delays the development of overt hypertension. Therefore the aim of the present work was to investigate the effects of SMF on autonomic cardiovascular control in adult spontaneously hypertensive rats.
  
  
  
  Experiments were performed in freely moving spontaneously hypertensive rats equipped with femoral arterial catheter for blood pressure recording. Spontaneously hypertensive rats were exposed for 30 days to upward-oriented SMF (n = 17) or downward-oriented SMF (n = 17) of 16 mT intensity. A control group of spontaneously hypertensive rats (n = 17) was not exposed to SMF. Neurogenic cardiovascular control was evaluated by spectral analysis of arterial blood pressure and heart rate short-term variability and baro-receptor reflex sensitivity using the sequence method.
  
  
  
  Exposure of spontaneously hypertensive rats to both upward- and downward-oriented SMF significantly reduced arterial blood pressure and enhanced baro-receptor reflex sensitivity. Downward-oriented SMF reduced heart rate, too. SMF of either orientation reduced systolic blood pressure variability in very low frequency domain while downward-oriented SMF also reduced low-frequency and increased high frequency domains.
  
  
  
  It follows that prolonged exposure to SMF is beneficial for neurogenic cardiovascular control in hypertension.
authors.affiliation: a Institute of Pharmacology , Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade , Belgrade , Serbia.
authors.forename: Tatjana
authors.initials: T
authors.lastname: Tasić
authors.affiliation: b Institute of Pathophysiology , Faculty of Medicine, University of Belgrade , Belgrade , Serbia.
authors.forename: Drago M
authors.initials: DM
authors.lastname: Djordjević
authors.affiliation: b Institute of Pathophysiology , Faculty of Medicine, University of Belgrade , Belgrade , Serbia.
authors.forename: Silvio R
authors.initials: SR
authors.lastname: De Luka
authors.affiliation: b Institute of Pathophysiology , Faculty of Medicine, University of Belgrade , Belgrade , Serbia.
authors.forename: Alexander M
authors.initials: AM
authors.lastname: Trbovich
authors.affiliation: a Institute of Pharmacology , Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade , Belgrade , Serbia.
authors.forename: Nina
authors.initials: N
authors.lastname: Japundžić-Žigon
mesh_terms: D000818:Animals; D017704:Baroreflex / Q000528:radiation effects*; D001794:Blood Pressure / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D006339:Heart Rate / Q000528:radiation effects*; D006973:Hypertension / Q000503:physiopathology* / Q000628:therapy*; D055909:Magnetic Field Therapy / Q000379:methods*; D060526:Magnetic Fields; D008297:Male; D000069336:Neurovascular Coupling / Q000528:radiation effects; D011829:Radiation Dosage; D051381:Rats; D011918:Rats, Inbred SHR; D016896:Treatment Outcome
keywords: Static magnetic field; baro-receptor reflex sensitivity; hypertension; short-term blood pressure variability; short-term heart rate variability