title: [Procedures on patients receiving NOACs : What's possible?]
abstract: Non-vitamin K antagonist oral anticoagulants (NOACs) are increasingly used in patients with deep vein thrombosis (DVT), pulmonary embolism (PE) and atrial fibrillation (AF). However, there is insufficient data concerning the periinterventional, perioperative, and intensive care management of patients on NOACs. Therefore, the recommendations regarding this management rely on pharmacokinetics of the particular NOAC in combination with the individual patient's characteristics, bleeding risk of the planned intervention/surgery, and urgency of the procedure. This review summarizes evidence and recommendations regarding the optimal periinterventional/perioperative antithrombotic management of patients on NOACs.
authors.affiliation: Klinik für Kardiologie, Pneumologie und Angiologie, Universitätsklinikum der Heinrich-Heine-Universität Düsseldorf, Moorenstraße 5, 40225, Düsseldorf, Deutschland. amin.polzin@med.uni-duesseldorf.de.
authors.forename: A
authors.initials: A
authors.lastname: Polzin
authors.affiliation: Klinik für Kardiologie, Pneumologie und Angiologie, Universitätsklinikum der Heinrich-Heine-Universität Düsseldorf, Moorenstraße 5, 40225, Düsseldorf, Deutschland.
authors.forename: M
authors.initials: M
authors.lastname: Kelm
authors.affiliation: Klinik für Kardiologie, Pneumologie und Angiologie, Universitätsklinikum der Heinrich-Heine-Universität Düsseldorf, Moorenstraße 5, 40225, Düsseldorf, Deutschland.
authors.forename: P
authors.initials: P
authors.lastname: Horn
mesh_terms: D061067:Antibodies, Monoclonal, Humanized / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000925:Anticoagulants / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001281:Atrial Fibrillation / Q000097:blood / Q000150:complications / Q000188:drug therapy; D003422:Critical Care; D004347:Drug Interactions; D006207:Half-Life; D006470:Hemorrhage / Q000097:blood / Q000139:chemically induced; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications; D011655:Pulmonary Embolism / Q000097:blood / Q000517:prevention & control; D012307:Risk Factors; D013514:Surgical Procedures, Operative; D013923:Thromboembolism / Q000097:blood* / Q000517:prevention & control*; D020246:Venous Thrombosis / Q000097:blood / Q000517:prevention & control; D014812:Vitamin K / Q000037:antagonists & inhibitors
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D000925:Anticoagulants; D014812:Vitamin K
keywords: Anticoagulants; Bleeding; Intensive care; Perioperative care; Pharmacokinetics