title: Adverse drug reactions to anticoagulants in Spain: analysis of the Spanish National Hospital Discharge Data (2010-2013).
abstract: To describe and analyse hospitalisations for adverse drug reactions (ADRs) involving anticoagulants. We also analysed the progress of the reactions over time, the factors related with ADRs.
  
  
  
  A retrospective, descriptive, epidemiological study.
  
  
  
  This study used the Spanish National Hospital Discharge Database (Conjunto Mínimo Básico de Datos, CMBD), over a 4-year period.
  
  
  
  We selected CMBD data corresponding to hospital discharges with a diagnosis of ADRs to anticoagulants (International Classification of Diseases-Ninth Revision, Clinical Modification (ICD-9-CM) code E934.2) in any diagnostic field during the study period.
  
  
  
  We calculated the annual incidence of ADRs to anticoagulants according to sex and age groups. The median lengths of hospital stay and in-hospital mortality (IHM) were also estimated for each year studied. Bivariate analyses of the changes in variables according to year were based on Poisson regression. IHM was analysed using logistic regression models. The estimates were expressed as ORs and their 95% CI.
  
  
  
  During the study period, 50 042 patients were hospitalised because of ADRs to anticoagulants (6.38% of all ADR-related admissions). The number of cases increased from 10 415 in 2010 to 13 891 in 2013. Cumulative incidence of ADRs to anticoagulants was significantly higher for men than women and in all age groups. An adjusted multivariate analysis revealed that IHM did not change significantly over time. We observed a statistically significant association between IHM and age, with the highest risk for the ≥85 age group (OR 2.67; 95% CI 2.44 to 2.93).
  
  
  
  The incidence of ADRs to anticoagulants in Spain increased from 2010 to 2013, and was significantly higher for men than women and in all age groups. Older patients were particularly susceptible to being hospitalised with an adverse reaction to an anticoagulant.
authors.affiliation: Preventive Medicine and Public Health Teaching and Research Unit, Health Sciences Faculty Rey Juan Carlos University, Alcorcón, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Carrasco-Garrido
authors.affiliation: Preventive Medicine and Public Health Teaching and Research Unit, Health Sciences Faculty Rey Juan Carlos University, Alcorcón, Spain.
authors.forename: V
authors.initials: V
authors.lastname: Hernández-Barrera
authors.affiliation: Preventive Medicine and Public Health Teaching and Research Unit, Health Sciences Faculty Rey Juan Carlos University, Alcorcón, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Esteban-Hernández
authors.affiliation: Preventive Medicine and Public Health Teaching and Research Unit, Health Sciences Faculty Rey Juan Carlos University, Alcorcón, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Jiménez-Trujillo
authors.affiliation: Preventive Medicine and Public Health Teaching and Research Unit, Health Sciences Faculty Rey Juan Carlos University, Alcorcón, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Álvaro-Meca
authors.affiliation: Preventive Medicine and Public Health Teaching and Research Unit, Health Sciences Faculty Rey Juan Carlos University, Alcorcón, Spain.
authors.forename: A
authors.initials: A
authors.lastname: López de Andrés
authors.affiliation: Pneumology Department, Hospital General Universitario Gregorio Marañon, Madrid, Spain.
authors.forename: J
authors.initials: J
authors.lastname: de Miguel Diez
authors.affiliation: Daiichi Sankyo Europe GmbH, Berlin, Germany.
authors.forename: J M
authors.initials: JM
authors.lastname: Rodríguez Barrios
authors.affiliation: Daiichi Sankyo España, S.A, Madrid, Spain.
authors.forename: J A
authors.initials: JA
authors.lastname: Muñoz Robles
authors.affiliation: Preventive Medicine and Public Health Teaching and Research Unit, Health Sciences Faculty Rey Juan Carlos University, Alcorcón, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Jiménez-García
mesh_terms: D000328:Adult; D000368:Aged; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects*; D064420:Drug-Related Side Effects and Adverse Reactions / Q000453:epidemiology*; D005260:Female; D006760:Hospitalization; D006801:Humans; D015994:Incidence; D007902:Length of Stay / Q000706:statistics & numerical data*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010351:Patient Discharge / Q000706:statistics & numerical data*; D012189:Retrospective Studies; D013030:Spain / Q000453:epidemiology
chemical_list: D000925:Anticoagulants
keywords: Adverse Drug Reactions; National Hospital Discharge Data; anticoagulants