title: Magnetic iron oxide nanoparticles grafted N-isopropylacrylamide/chitosan copolymer for the extraction and determination of letrozole in human biological samples.
abstract: Magnetic iron oxide nanoparticles are used for the extraction of a drug from an aqueous solution. In the current study, the magnetic iron oxide nanoparticles were synthesized via a facile coprecipitation approach, and then modified by (3-mercaptopropyl)trimethoxysilane followed by grafting thermosensitive polymer N-isopropylacrylamide and biopolymer chitosan. Structure, morphology, size, thermal resistance, specific surface area, and magnetic properties of the grafted nanosorbent were characterized by using Fourier transform infrared spectroscopy, field emission scanning electron microscopy, transmission electron microscopy, elemental analysis, thermogravimetric analysis, specific surface area analysis and vibrating sample magnetometry. The effective parameters on sorption/desorption of letrozole on grafted magnetic nanosorbent were evaluated. The best sorption of letrozole via the grafted nanosorbent occurred at 20°C at an optimum pH of 7. The extraction of trace letrozole in human biological fluids is investigated and revealed 89.1 and 97.8% recovery in plasma and urine, respectively.
authors.affiliation: Department of Chemistry, Central Tehran Branch, Islamic Azad University, Tehran, Iran.
authors.forename: Mercede
authors.initials: M
authors.lastname: Khalaj Moazen
authors.affiliation: Department of Chemistry, Central Tehran Branch, Islamic Azad University, Tehran, Iran.
authors.forename: Homayon
authors.identifier: http://orcid.org/0000-0001-5041-8059
authors.initials: H
authors.lastname: Ahmad Panahi
mesh_terms: D000178:Acrylamides; D048271:Chitosan; D005290:Ferric Compounds; D006801:Humans; D006863:Hydrogen-Ion Concentration; D000077289:Letrozole; D058185:Magnetite Nanoparticles; D009570:Nitriles / Q000097:blood / Q000302:isolation & purification* / Q000652:urine; D052616:Solid Phase Extraction; D017550:Spectroscopy, Fourier Transform Infrared; D014230:Triazoles / Q000097:blood / Q000302:isolation & purification* / Q000652:urine
chemical_list: D000178:Acrylamides; D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; D009570:Nitriles; D014230:Triazoles; C000499:ferric oxide; D000077289:Letrozole; D048271:Chitosan; C067295:N-isopropylacrylamide
keywords: biological samples; letrozole; nanostructures; polymer grafting; solid-phase extraction
  