title: Novel Biomarker MicroRNAs for Subtyping of Acute Coronary Syndrome: A Bioinformatics Approach.
abstract: Acute coronary syndrome (ACS) is a life-threatening disease that affects more than half a million people in United States. We currently lack molecular biomarkers to distinguish the unstable angina (UA) and acute myocardial infarction (AMI), which are the two subtypes of ACS. MicroRNAs play significant roles in biological processes and serve as good candidates for biomarkers. In this work, we collected microRNA datasets from the Gene Expression Omnibus database and identified specific microRNAs in different subtypes and universal microRNAs in all subtypes based on our novel network-based bioinformatics approach. These microRNAs were studied for ACS association by pathway enrichment analysis of their target genes. AMI and UA were associated with 27 and 26 microRNAs, respectively, nine of them were detected for both AMI and UA, and five from each subtype had been reported previously. The remaining 22 and 21 microRNAs are novel microRNA biomarkers for AMI and UA, respectively. The findings are then supported by pathway enrichment analysis of the targets of these microRNAs. These novel microRNAs deserve further validation and will be helpful for personalized ACS diagnosis.
authors.affiliation: Center for Systems Biology, Soochow University, Suzhou 215006, China; Biomedical Informatics Division, UC San Diego, La Jolla, CA, USA; Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, China.
authors.forename: Yujie
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Center for Systems Biology, Soochow University, Suzhou 215006, China.
authors.forename: Yuxin
authors.initials: Y
authors.lastname: Lin
authors.affiliation: Center for Systems Biology, Soochow University, Suzhou 215006, China.
authors.forename: Wenying
authors.initials: W
authors.lastname: Yan
authors.affiliation: Center for Systems Biology, Soochow University, Suzhou 215006, China.
authors.forename: Zhandong
authors.initials: Z
authors.lastname: Sun
authors.affiliation: School of Medicine, Soochow University, Suzhou 215123, China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Jiang
authors.affiliation: Center for Systems Biology, Soochow University, Suzhou 215006, China.
authors.forename: Bairong
authors.identifier: 0000-0003-2899-1531
authors.initials: B
authors.lastname: Shen
authors.affiliation: Biomedical Informatics Division, UC San Diego, La Jolla, CA, USA.
authors.forename: Xiaoqian
authors.initials: X
authors.lastname: Jiang
authors.affiliation: Department of Cardiovascular Internal Medicine, Wuxi Third People's Hospital, Wuxi 214041, China.
authors.forename: Jingjing
authors.identifier: 0000-0001-9243-2414
authors.initials: J
authors.lastname: Shi
mesh_terms: D054058:Acute Coronary Syndrome / Q000235:genetics* / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism*; D019295:Computational Biology / Q000379:methods; D015870:Gene Expression / Q000235:genetics; D006801:Humans; D035683:MicroRNAs / Q000235:genetics
chemical_list: D015415:Biomarkers; D035683:MicroRNAs