title: Gambling disorder: a side effect of an off-label prescription of baclofen-literature review.
abstract: The use of high-dose baclofen emerged in 2008 in the treatment of alcohol-use disorders. Its prescription is still off-label in France, but recent trials have suggested the interest of using high doses for alcohol dependence, so we have to deal with an increase in its use. However, we still have few data about the adverse effects of a high-dose baclofen prescription, especially in complex addictive disorders. We present a case of a 32-year-old man who sought treatment for gambling disorders (GDs). He had complex addictive disorders, including alcohol-use disorders and GDs. He developed a severe GD, after treatment with a high dose of baclofen. The maximum dose was 160 mg/day, prescribed for his alcohol-use disorders. According to the Naranjo algorithm, the score was +7, it enabled to conclude that problem of gambling was probably imputable to baclofen. We discuss this case with reference to literature.
authors.affiliation: ERCR SPURBO, Department of Addictive Disorders, Université de Bretagne Occidentale, Brest, France.|Addictology Department, Brest University Hospital, Brest, France.
authors.forename: Morgane
authors.initials: M
authors.lastname: Guillou-Landreat
authors.affiliation: Clinical Pharmacology, CHU Nantes, Nantes, Pays de la Loire, France.|EA 4275 "Biostatistics, Pharmacoepidemiology and Subjective Measures in Health Sciences," Nantes University, Nantes, France.
authors.forename: Caroline
authors.initials: C
authors.lastname: Victorri Vigneau
authors.affiliation: Clinical Pharmacology, CHU Nantes, Nantes, Pays de la Loire, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Gerardin
mesh_terms: D000328:Adult; D000427:Alcohol Deterrents / Q000009:adverse effects*; D019973:Alcohol-Related Disorders / Q000188:drug therapy; D001418:Baclofen / Q000009:adverse effects*; D003937:Diagnosis, Differential; D058786:GABA-B Receptor Agonists / Q000009:adverse effects*; D005715:Gambling / Q000139:chemically induced*; D006801:Humans; D008297:Male; D056687:Off-Label Use; D016896:Treatment Outcome
chemical_list: D000427:Alcohol Deterrents; D058786:GABA-B Receptor Agonists; D001418:Baclofen