title: Coordinated Plasticity between Barrel Cortical Glutamatergic and GABAergic Neurons during Associative Memory.
abstract: Neural plasticity is associated with memory formation. The coordinated refinement and interaction between cortical glutamatergic and GABAergic neurons remain elusive in associative memory, which we examine in a mouse model of associative learning. In the mice that show odorant-induced whisker motion after pairing whisker and odor stimulations, the barrel cortical glutamatergic and GABAergic neurons are recruited to encode the newly learnt odor signal alongside the innate whisker signal. These glutamatergic neurons are functionally upregulated, and GABAergic neurons are refined in a homeostatic manner. The mutual innervations between these glutamatergic and GABAergic neurons are upregulated. The analyses by high throughput sequencing show that certain microRNAs related to regulating synapses and neurons are involved in this cross-modal reflex. Thus, the coactivation of the sensory cortices through epigenetic processes recruits their glutamatergic and GABAergic neurons to be the associative memory cells as well as drive their coordinated refinements toward the optimal state for the storage of the associated signals.
authors.affiliation: Department of Pathophysiology, Bengbu Medical College, Anhui 233000, China.
authors.forename: Fenxia
authors.initials: F
authors.lastname: Yan
authors.affiliation: State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, University of Chinese Academy of Sciences, Beijing 100101, China.
authors.forename: Zilong
authors.initials: Z
authors.lastname: Gao
authors.affiliation: Department of Pathophysiology, Bengbu Medical College, Anhui 233000, China.
authors.forename: Pin
authors.initials: P
authors.lastname: Chen
authors.affiliation: Department of Pathophysiology, Bengbu Medical College, Anhui 233000, China.
authors.forename: Li
authors.initials: L
authors.lastname: Huang
authors.affiliation: State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, University of Chinese Academy of Sciences, Beijing 100101, China.
authors.forename: Dangui
authors.initials: D
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, University of Chinese Academy of Sciences, Beijing 100101, China.
authors.forename: Na
authors.initials: N
authors.lastname: Chen
authors.affiliation: Department of Pathophysiology, Bengbu Medical College, Anhui 233000, China.
authors.forename: Ruixiang
authors.initials: R
authors.lastname: Wu
authors.affiliation: State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, University of Chinese Academy of Sciences, Beijing 100101, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Feng
authors.affiliation: State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, University of Chinese Academy of Sciences, Beijing 100101, China.
authors.forename: Shan
authors.initials: S
authors.lastname: Cui
authors.affiliation: School of Pharmacy, Qingdao University, 38 Dengzhou, Shandong 266021, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Lu
authors.affiliation: Department of Pathophysiology, Bengbu Medical College, Anhui 233000, China; State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, University of Chinese Academy of Sciences, Beijing 100101, China; School of Pharmacy, Qingdao University, 38 Dengzhou, Shandong 266021, China.
authors.forename: Jin-Hui
authors.identifier: 0000-0001-6934-3309
authors.initials: JH
authors.lastname: Wang
mesh_terms: D000818:Animals; D001245:Association Learning / Q000502:physiology*; D059330:GABAergic Neurons / Q000737:chemistry / Q000502:physiology*; D018698:Glutamic Acid / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D036641:Microscopy, Fluorescence, Multiphoton / Q000379:methods; D009473:Neuronal Plasticity / Q000502:physiology*; D009924:Organ Culture Techniques; D010812:Physical Stimulation / Q000379:methods; D013003:Somatosensory Cortex / Q000737:chemistry / Q000502:physiology*; D014738:Vibrissae / Q000502:physiology*
chemical_list: D018698:Glutamic Acid