title: Serum Klotho (but not haplotypes) associate with the post-myocardial infarction status of older adults.
abstract: The number of deaths from vascular diseases is incredibly high worldwide, and reliable markers for major events are still needed. The current cross-sectional study investigated the association of Klotho haplotypes and Klotho serum levels with classic risk factors and a clinical history of vascular events.
  Clinical, anthropometric, biochemical and nutritional assessments were conducted with 168 older adults, complemented by genotyping (rs9536314 and rs9527025) and the detection of serum Klotho (ELISA).
  Klotho levels and haplotypes did not associate with most classic risk factors for vascular events, including markers such as C-reactive protein and homocysteine. A positive association was only found between Klotho levels and the previous occurrence of a myocardial infarction by both correlational (p=0.006) and variance analyses (p<0.001), and these associations were independent of the context.
  Our results suggest that serum Klotho is higher in individuals with a clinical history of myocardial infarction but not with a history of coronary artery disease or stroke. None of the Klotho haplotypes were associated with the variables investigated herein.
authors.affiliation: Universidade de Brasília (UnB), Brasília/DF, Brazil.
authors.forename: Roberta S
authors.initials: RS
authors.lastname: Paula
authors.affiliation: Universidade de Brasília (UnB), Brasília/DF, Brazil.
authors.forename: Vinícius C
authors.initials: VC
authors.lastname: Souza
authors.affiliation: Universidade de Brasília (UnB), Brasília/DF, Brazil.
authors.forename: Wilcelly
authors.initials: W
authors.lastname: Machado-Silva
authors.affiliation: Universidade de Brasília (UnB), Brasília/DF, Brazil.
authors.forename: Bruno Ratier S
authors.initials: BR
authors.lastname: Almeida
authors.affiliation: Centro Universitário de Brasília (UNICEUB), Brasília/DF, Brazil.
authors.forename: Andersen C
authors.initials: AC
authors.lastname: Daros
authors.affiliation: Universidade Católica de Brasília (UCB-DF), Brasília/DF, Brazil.
authors.forename: Lucy
authors.initials: L
authors.lastname: Gomes
authors.affiliation: Universidade Católica de Brasília (UCB-DF), Brasília/DF, Brazil.|Faculdades Promove (ICESP), Brasília/DF, Brazil.
authors.forename: Aparecido P
authors.initials: AP
authors.lastname: Ferreira
authors.affiliation: Universidade Federal de Juiz de Fora (UFJF), Juiz de Fora/MG, Brazil.
authors.forename: Ciro J
authors.initials: CJ
authors.lastname: Brito
authors.affiliation: Universidade Católica de Brasília (UCB-DF), Brasília/DF, Brazil.
authors.forename: Cláudio
authors.initials: C
authors.lastname: Córdova
authors.affiliation: Universidade de Brasília (UnB), Brasília/DF, Brazil.|Universidade Católica de Brasília (UCB-DF), Brasília/DF, Brazil.
authors.forename: Clayton F
authors.initials: CF
authors.lastname: Moraes
authors.affiliation: Universidade de Brasília (UnB), Brasília/DF, Brazil.
authors.forename: Otávio T
authors.initials: OT
authors.lastname: Nóbrega
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D000886:Anthropometry; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D003324:Coronary Artery Disease / Q000097:blood / Q000235:genetics; D003430:Cross-Sectional Studies; D002149:Energy Intake; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D060005:Genotyping Techniques; D005966:Glucuronidase / Q000097:blood* / Q000235:genetics*; D006239:Haplotypes; D006710:Homocysteine / Q000097:blood; D006801:Humans; D000090265:Klotho Proteins; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000235:genetics; D015596:Nutrition Assessment; D012016:Reference Values; D012307:Risk Factors; D012737:Sex Factors; D018709:Statistics, Nonparametric; D020521:Stroke / Q000097:blood / Q000235:genetics
chemical_list: D015415:Biomarkers; D006710:Homocysteine; D002097:C-Reactive Protein; D005966:Glucuronidase; D000090265:Klotho Proteins