title: Intrinsically89Zr-labeled Gd2O2S:Eu nanophosphors with highin vivostability for dual-modality imaging.
abstract: Radioluminescence imaging (RLI) employs high energy particles from radioisotope decay forin situexcitation of selected nanophosphors. Co-injection of radiopharmaceuticals and nanophosphors suffers from suboptimal RL efficiency owing to the large separation between the source and the emitter. In addition, vastly different pharmacokinetic profiles of the two further impede the practical applications of this approach. To overcome the above challenges, chelator-free radiolabeled nanophosphors with excellent RL efficiency and dual-modality imaging capabilities have been proposed. Abundant O2-donors on Gd2O2S:Eu could intrinsically chelate oxophilic radionuclide89Zr with ~80 % labeling yield. Positron emission tomography demonstrated superb long-term radiostability of [89Zr]Gd2O2S:Eu@PEG nanoparticlesin vivo, and a conventional optical imaging system was used to study radiouminescence properties of [89Zr]Gd2O2S:Eu@PEG nanoparticlesin vitroandin vivo.
authors.affiliation: School of Mechanical & Electrical Engineering, Nanchang UniversityJiangxi, China; Department of Radiology, University of Wisconsin-MadisonMadison, WI.
authors.forename: Fanrong
authors.initials: F
authors.lastname: Ai
authors.affiliation: Materials Science Program, University of Wisconsin-Madison Madison, WI.
authors.forename: Shreya
authors.initials: S
authors.lastname: Goel
authors.affiliation: Department of Radiology, University of Wisconsin-MadisonMadison, WI; Engineering Research Centre of Molecular and Neuro Imaging of the Ministry of Education, School of Life Science and Technology, Xidian UniversityXi'an, Shaanxi, China.
authors.forename: Yonghua
authors.initials: Y
authors.lastname: Zhan
authors.affiliation: Department of Medical Physics, University of Wisconsin-Madison Madison, WI.
authors.forename: Hector F
authors.initials: HF
authors.lastname: Valdovinos
authors.affiliation: Department of Radiology, University of Wisconsin-Madison Madison, WI.
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
authors.affiliation: Department of Medical Physics, University of Wisconsin-Madison Madison, WI.
authors.forename: Todd E
authors.initials: TE
authors.lastname: Barnhart
authors.affiliation: Department of Radiology, University of Wisconsin-MadisonMadison, WI; Materials Science Program, University of Wisconsin-MadisonMadison, WI; Department of Medical Physics, University of Wisconsin-MadisonMadison, WI; University of Wisconsin Carbone Cancer CentreMadison, WI.
authors.forename: Weibo
authors.initials: W
authors.lastname: Cai
keywords: Radioluminescence; gadolinium oxysulfide; multimodality imaging; nanophosphors; positron emission tomography