title: [Clinical effectiveness of salvianolic acid B and triamcinolone acetonide in treatment of oral submucous fibrosis].
abstract: Objective:To evaluate the clinical effectiveness of salvianolic acid B (SA-B) and triamcinolone acetonide (TA) by means of combined intralesional injection in the treatment of oral submucous fibrosis (OSF).Methods:According to clinical findings and symptoms, TA combined with SA-B were consecutively applied intralesionally 1 time weekly for 30 times. Mouth opening degree, color change of the buccal mucosae and numeral increase of the capillary vessels were determined by degree Ⅰ-Ⅳ visual analog scale were evaluated at 12, 24, and 36 months, respectively.Results:One hundred and fourteen subjects fulfilled the study without obvious adverse reactions. After treatment for 1 year, the net gain in mouth opening of the early stage group was (5.5 ± 1.5) mm at 12 months, (8.8 ± 1.6) mm at 24 months and (12.0±1.2) mm at 36 months. The net gain in mouth opening of the middle stage group were (5.3±1.7) mm at 12 months, (10.5±1.5) mm at 24 months and (14.5±2.4) mm at 36 months. The net gain in mouth opening of the advanced stage group were (5.7±1.3) mm at 12 months, (13.7±1.3) mm at 24 months and (15.5±1.5) mm at 36 months. The effective rates of color change of the buccal mucosae and numeral increase of the capillary vessels after treatment for 36 months were 100% in early stage group, 93% (51/55) in middle stage group and 90% (36/40) in advanced stage group.Conclusions:TA and SA-B combined intralesional injection in the treatment of oral submucous fibrosis is effective.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Xiangya Hospital, Institute of Oral Precancerous Lesions, Central South University, Changsha 410008, China.
authors.forename: X C
authors.initials: XC
authors.lastname: Jian
authors.affiliation: Department of Oral and Maxillofacial Surgery, Xiangya Hospital, Institute of Oral Precancerous Lesions, Central South University, Changsha 410008, China.
authors.forename: L
authors.initials: L
authors.lastname: Zheng
authors.affiliation: Department of Oral and Maxillofacial Surgery, Xiangya Hospital, Institute of Oral Precancerous Lesions, Central South University, Changsha 410008, China.
authors.forename: R
authors.initials: R
authors.lastname: Zhu
authors.affiliation: Department of Oral Mucous Disease, Stomatology Center, Affiliate Haikou Hospital of Central South University Xiangya Medical School & Hainan Provincial Stomatology Center, Haikou 570208, China.
authors.forename: B P
authors.initials: BP
authors.lastname: Wang
authors.affiliation: Department of Oral Mucous Disease, Stomatology Center, Affiliate Haikou Hospital of Central South University Xiangya Medical School & Hainan Provincial Stomatology Center, Haikou 570208, China.
authors.forename: T
authors.initials: T
authors.lastname: Zhou
authors.affiliation: Department of Oral Mucous Disease, Stomatology Center, Affiliate Haikou Hospital of Central South University Xiangya Medical School & Hainan Provincial Stomatology Center, Haikou 570208, China.
authors.forename: Y X
authors.initials: YX
authors.lastname: Du
mesh_terms: D001572:Benzofurans / Q000627:therapeutic use*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D009914:Oral Submucous Fibrosis / Q000188:drug therapy*; D016896:Treatment Outcome; D014222:Triamcinolone Acetonide / Q000627:therapeutic use*; D064232:Visual Analog Scale; D053630:Depsides
chemical_list: D001572:Benzofurans; D004365:Drugs, Chinese Herbal; D007166:Immunosuppressive Agents; D014222:Triamcinolone Acetonide; C076944:salvianolic acid B; D053630:Depsides