title: Occupational exposure to solvents and risk of head and neck cancer in women: a population-based case-control study in France.
abstract: Our objective was to investigate the association between head and neck cancer and occupational exposure to chlorinated, oxygenated and petroleum solvents in women.
  
  
  
  Investigation of occupational and environmental CAuses of REspiratory cancers (ICARE), a French population-based case-control study, included 296 squamous cell carcinomas of the head and neck (HNSCC) in women and 775 female controls. Lifelong occupational history was collected. Job-exposure matrices allowed to assess exposure to 5 chlorinated solvents (carbon tetrachloride; chloroform; methylene chloride; perchloroethylene; trichloroethylene), 5 petroleum solvents (benzene; special petroleum product; gasoline; white spirits and other light aromatic mixtures; diesel, fuels and kerosene) and 5 oxygenated solvents (alcohols; ketones and esters; ethylene glycol; diethyl ether; tetrahydrofuran). OR and 95% CIs, adjusted for smoking, alcohol drinking, age and geographical area, were estimated with logistic models.
  
  
  
  Elevated ORs were observed among women ever exposed to perchloroethylene (OR=2.97, 95% CI 1.05 to 8.45) and trichloroethylene (OR=2.15, 95% CI 1.21 to 3.81). These ORs increased with exposure duration (OR=3.75, 95% CI 0.64 to 21.9 and OR=4.44, 95% CI 1.56 to 12.6 for 10 years or more, respectively). No significantly increased risk of HNSCC was found for occupational exposure to the other chlorinated, petroleum or oxygenated solvents.
  
  
  
  These findings suggest that exposure to perchloroethylene or trichloroethylene may increase the risk of HNSCC in women. In our study, there is no clear evidence that the other studied solvents are risk factors for HNSCC.
authors.affiliation: Population-based Epidemiologic Cohorts Unit, Inserm, Villejuif, France.|University of Versailles St-Quentin, Villejuif, France.
authors.forename: Matthieu
authors.initials: M
authors.lastname: Carton
authors.affiliation: Faculté de Médecine, Inserm U 1085-Institut de Recherche en Santé, Environnement et Travail (IRSET), Pointe-à-Pitre, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Barul
authors.affiliation: Sorbonne Universités, UPMC Univ Paris 06, INSERM, Institut Pierre Louis d'épidémiologie et de Santé Publique (IPLESP UMRS 1136), Paris, France.
authors.forename: Gwenn
authors.initials: G
authors.lastname: Menvielle
authors.affiliation: Population-based Epidemiologic Cohorts Unit, Inserm, Villejuif, France.|University of Versailles St-Quentin, Villejuif, France.
authors.forename: Diane
authors.initials: D
authors.lastname: Cyr
authors.affiliation: Inserm, CESP Centre for Research in Epidemiology and Population Health, Environmental Epidemiology of Cancer Team, Villejuif, France.|University Paris-Sud, Villejuif, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Sanchez
authors.affiliation: Department of Occupational Health, French Institute for Public Health Surveillance, Saint Maurice, France.|UMRESTTE (Epidemiological Research and Surveillance Unit in Transport, Occupation and Environment), University Claude Bernard, Lyon, France.
authors.forename: Corinne
authors.initials: C
authors.lastname: Pilorget
authors.affiliation: Hérault Cancer Registry, Montpellier, France.
authors.forename: Brigitte
authors.initials: B
authors.lastname: Trétarre
authors.affiliation: Inserm, CESP Centre for Research in Epidemiology and Population Health, Environmental Epidemiology of Cancer Team, Villejuif, France.|University Paris-Sud, Villejuif, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Stücker
authors.affiliation: Faculté de Médecine, Inserm U 1085-Institut de Recherche en Santé, Environnement et Travail (IRSET), Pointe-à-Pitre, France.
authors.forename: Danièle
authors.initials: D
authors.lastname: Luce
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000438:Alcohols / Q000633:toxicity*; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced* / Q000453:epidemiology; D016022:Case-Control Studies; D005260:Female; D005602:France / Q000453:epidemiology; D006258:Head and Neck Neoplasms / Q000139:chemically induced* / Q000453:epidemiology; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000633:toxicity*; D016273:Occupational Exposure / Q000009:adverse effects*; D012307:Risk Factors; D012997:Solvents / Q000633:toxicity*; D000077195:Squamous Cell Carcinoma of Head and Neck; D055815:Young Adult
chemical_list: D000438:Alcohols; D006843:Hydrocarbons, Chlorinated; D012997:Solvents
keywords: Cancer; head and neck; occupational exposures; perchloroethylene; trichloroethylene; women