title: Etanercept in the treatment of refractory SAPHO syndrome.
abstract: OBJECTIVE
  To explore the application and efficacy of TNF-α inhibitors in the treatment of SAPHO syndrome.
  
  
  METHODS
  Two cases of refractory SAPHO syndrome were successfully treated with etanercept. And pain scores, laboratory parameters and functional index were used to judge the efficacies. Literature was also systemically reviewed.
  
  
  RESULTS
  Both patients achieved marked clinical remission. There was no obvious toxic or adverse response.
  
  
  CONCLUSIONS
  Etanercept has rapid and definite efficacies in the treatment of patients with refractory SAPHO syndrome.
authors.affiliation: Department of Rheumatology & Immunology, Shengli Oilfield Central Hospital Dongying, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Rheumatology & Immunology, Shengli Oilfield Central Hospital Dongying, China.
authors.forename: Zhaomeng
authors.initials: Z
authors.lastname: Gao
keywords: SAPHO syndrome; discitis; etanercept; tumor necrosis factor-alpha