title: Diverting Ileostomy for the Treatment of Severe, Refractory, Pediatric Inflammatory Bowel Disease.
abstract: Diverting ileostomy is used as a temporizing therapy in patients with perianal Crohn disease; however, little data exist regarding its use for colonic disease. The primary aim of the present study was to determine the role of diversion in severe refractory colonic inflammatory bowel disease (IBD) in a pediatric population.
  
  
  
  Retrospective study of patients who underwent diverting ileostomy at The Children's Hospital of Philadelphia from 2000 to 2014 for the management of severe, refractory colonic IBD. Clinical variables were compared in the 1 year before ileostomy and 1 year after diversion. Surgical and disease outcomes including changes in diagnosis were reviewed through 2015.
  
  
  
  Twenty-four patients underwent diverting ileostomy for refractory colonic disease. Initial diagnoses were Crohn disease in 10 (42%), ulcerative colitis in 1 (4%), and IBD-unclassified in 13 patients (54%). Comparing data before and after surgery, there were statistically significant improvements in height and weight velocities, height velocity z score, blood transfusion requirement, hemoglobin, and hospitalization rates. Chronic steroid use decreased from 71% to 22%. At the conclusion of the study, 10 patients had undergone subsequent colectomy, 7 had successful bowel reanastomosis, and 7 remain diverted. Seven patients (29%) had a change in diagnosis. There were 13 surgical complications in 7 subjects, including prolapse reduction, stoma revision, and resection of ischemic bowel.
  
  
  
  In pediatric patients with refractory colonic IBD, diverting ileostomy can be a successful intervention to induce clinical stability. Importantly, diversion is a steroid-sparing therapy and allows additional time to clarify the diagnosis.
authors.affiliation: *Department of Pediatrics †Department of Biomedical Health Informatics, The Children's Hospital of Philadelphia ‡Perelman School of Medicine, University of Pennsylvania §Department of Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA.
authors.forename: Elizabeth C
authors.initials: EC
authors.lastname: Maxwell
authors.forename: Noor
authors.initials: N
authors.lastname: Dawany
authors.forename: Robert N
authors.initials: RN
authors.lastname: Baldassano
authors.forename: Petar
authors.initials: P
authors.lastname: Mamula
authors.forename: Peter
authors.initials: P
authors.lastname: Mattei
authors.forename: Lindsey
authors.initials: L
authors.lastname: Albenberg
authors.forename: Judith R
authors.initials: JR
authors.lastname: Kelsen
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007081:Ileostomy; D015212:Inflammatory Bowel Diseases / Q000175:diagnosis / Q000601:surgery*; D008297:Male; D011183:Postoperative Complications / Q000175:diagnosis / Q000453:epidemiology; D012189:Retrospective Studies; D012720:Severity of Illness Index; D016896:Treatment Outcome