title: [Van Wyk-Grumbach syndrome: A case report and  literature review].
abstract: Van Wyk-Grumbach syndrome (VWGS) is a rare complication of prolonged untreated juvenile hypothyroidism characterized by precocious puberty and enlarged multicystic ovaries. A 13-year-old girl visited our outpatient clinic due to menstrual irregularities. She had precocious puberty, pituitary hyperplasia and multiple cystic ovaries in addition to clinical signs of severe congenital hypothyroidism. After the initiation of L-thyroxine therapy, the symptoms were alleviated in a short time. This rare syndrome is easy to be misdiagnosed as pituitary and ovarian tumor. High degree of suspicion and timely diagnosis can prevent unnecessary surgical procedures because the symptoms can be reversed with thyroid hormone supplementation.
authors.affiliation: Department of Endorcrinology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Jin
authors.affiliation: Department of Endorcrinology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Endorcrinology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Mo
authors.affiliation: Department of Endorcrinology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.affiliation: Department of Endorcrinology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Xie
mesh_terms: D000293:Adolescent; D003409:Congenital Hypothyroidism / Q000150:complications* / Q000175:diagnosis* / Q000209:etiology; D003937:Diagnosis, Differential; D003951:Diagnostic Errors; D005260:Female; D006801:Humans; D006964:Hyperpituitarism; D006965:Hyperplasia; D008599:Menstruation Disturbances / Q000209:etiology; D010048:Ovarian Cysts / Q000175:diagnosis* / Q000209:etiology*; D010053:Ovary / Q000473:pathology*; D010902:Pituitary Gland / Q000473:pathology; D011629:Puberty, Precocious / Q000175:diagnosis* / Q000209:etiology*; D013577:Syndrome; D013974:Thyroxine / Q000627:therapeutic use*
chemical_list: D013974:Thyroxine