title: Ebola Vaccination Using a DNA Vaccine Coated on PLGA-PLL/γPGA Nanoparticles Administered Using a Microneedle Patch.
abstract: Ebola DNA vaccine is incorporated into PLGA-PLL/γPGA nanoparticles and administered to skin using a microneedle (MN) patch. The nanoparticle delivery system increases vaccine thermostability and immunogenicity compared to free vaccine. Vaccination by MN patch produces stronger immune responses than intramuscular administration.
authors.affiliation: Institute of Medical Science and Technology, National Sun Yat-sen University, 70 Lienhai Rd., Kaohsiung, 80424, Taiwan, R.O.C.|School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive, Atlanta, GA, 30332, USA.
authors.forename: Hung-Wei
authors.initials: HW
authors.lastname: Yang
authors.affiliation: Department of Microbiology and Immunology and Emory Vaccine Center, Emory University School of Medicine, 1648 Pierce Drive, Atlanta, GA, 30322, USA.
authors.forename: Ling
authors.initials: L
authors.lastname: Ye
authors.affiliation: School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive, Atlanta, GA, 30332, USA.|College of Materials Science and Engineering, Beijing University of Chemical Technology, 15 Beisanhuandong Road, Chaoyang District, Beijing, China.
authors.forename: Xin Dong
authors.initials: XD
authors.lastname: Guo
authors.affiliation: Department of Microbiology and Immunology and Emory Vaccine Center, Emory University School of Medicine, 1648 Pierce Drive, Atlanta, GA, 30322, USA.
authors.forename: Chinglai
authors.initials: C
authors.lastname: Yang
authors.affiliation: Department of Microbiology and Immunology and Emory Vaccine Center, Emory University School of Medicine, 1648 Pierce Drive, Atlanta, GA, 30322, USA.
authors.forename: Richard W
authors.initials: RW
authors.lastname: Compans
authors.affiliation: School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive, Atlanta, GA, 30332, USA.
authors.forename: Mark R
authors.initials: MR
authors.lastname: Prausnitz
mesh_terms: D000818:Animals; D046129:Ebola Vaccines / Q000737:chemistry / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D000071497:Immunogenicity, Vaccine; D019344:Lactic Acid / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use; D009339:Needles; D011099:Polyglutamic Acid / Q000737:chemistry / Q000494:pharmacology; D011100:Polyglycolic Acid / Q000737:chemistry / Q000494:pharmacology; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011107:Polylysine / Q000737:chemistry / Q000494:pharmacology; D019444:Vaccines, DNA / Q000737:chemistry / Q000494:pharmacology
chemical_list: D046129:Ebola Vaccines; D019444:Vaccines, DNA; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011107:Polylysine; D011099:Polyglutamic Acid; D011100:Polyglycolic Acid; D019344:Lactic Acid
keywords: Ebola DNA vaccine; cationic nanoparticles; indradermal vaccine delivery; microneedle patch; minimally invasive skin vaccination