title: The Natural Course of Atopic Dermatitis and the Association with Asthma.
abstract: In this paper, we aimed to explore the potential mechanism underlying atopic dermatitis (AD) and its association with asthma. The BALB/c mice were randomly assigned to three groups, including the vehicle control (VD) group, the AD group, and the treatment (TR) group. The AD mice model was successfully constructed in the AD and TR group. The dermatitis severity scores and skin lesions were significantly increased in AD mice after DNCB application. Airway responsiveness in the AD group was significantly higher than in the TR group. The number of inflammatory cells was increased in skin lesions and bronchoalveolar lavage fluid (BALF) of AD mice. The levels of IL-4, IL-5, IFN-γ, and OVA-IgE in BALF supernatants of mice in the AD group were higher than those in the VC group. All the changes in AD mice were decreased by tacrolimus. These results indicate that AD may be a significant risk factor for atopic asthma development.
authors.affiliation: Department of Internal Medicine, Kingsbrook Jewish Medical Center, 585 Schenectady Ave, Brooklyn, NY, USA.
authors.forename: Min
authors.initials: M
authors.lastname: Qiao
authors.affiliation: Department of Dermatology, Shanghai Sixth People's Hospital Affiliated of Shanghai Jiaotong University, Shanghai, China.
authors.forename: Deqi
authors.initials: D
authors.lastname: Xiao
authors.affiliation: Department of Emergency, Shanghai Ninth People's Hospital Affiliated of Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: Li
authors.initials: L
authors.lastname: Qian
authors.affiliation: Department of Emergency, Shanghai Ninth People's Hospital Affiliated of Shanghai Jiaotong University School of Medicine, Shanghai, China. qiaojianouhhhhh@hotmail.com.|Department of Respiratory Medicine, Shanghai Ninth People's Hospital Affiliated of Shanghai Jiaotong University School of Medicine, No. 639, Zhizaoju Road, Huangpu District, Shanghai, 200011, China. qiaojianouhhhhh@hotmail.com.
authors.forename: Jian'ou
authors.initials: J
authors.lastname: Qiao
mesh_terms: D000818:Animals; D001249:Asthma / Q000209:etiology*; D001992:Bronchoalveolar Lavage Fluid / Q000276:immunology; D003876:Dermatitis, Atopic / Q000150:complications*; D004137:Dinitrochlorobenzene / Q000494:pharmacology; D004485:Eczema; D051379:Mice; D008807:Mice, Inbred BALB C; D016559:Tacrolimus / Q000494:pharmacology
chemical_list: D004137:Dinitrochlorobenzene; D016559:Tacrolimus
keywords: airway inflammation; airway responsiveness; asthma; atopic dermatitis; tacrolimus