title: H2S as a possible therapeutic alternative for the treatment of hypertensive kidney injury.
abstract: Hypertension is the most common cause of cardiovascular morbidities and mortalities, and a major risk factor for renal dysfunction. It is considered one of the causes of chronic kidney disease, which progresses into end-stage renal disease and eventually loss of renal function. Yet, the mechanism underlying the pathogenesis of hypertension and its associated kidney injury is still poorly understood. Moreover, despite existing antihypertensive therapies, achievement of blood pressure control and preservation of renal function still remain a worldwide public health challenge in a subset of hypertensive patients. Therefore, novel modes of intervention are in demand. Hydrogen sulfide (H2S), a gaseous signaling molecule, has been established to possess antihypertensive and renoprotective properties, which may represent an important therapeutic alternative for the treatment of hypertension and kidney injury. This review discusses recent findings about H2S in hypertension and kidney injury from both experimental and clinical studies. It also addresses future direction regarding therapeutic use of H2S.
authors.affiliation: Division of Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.. Electronic address: profduu@yahoo.com.
authors.forename: George J
authors.initials: GJ
authors.lastname: Dugbartey
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D006801:Humans; D006862:Hydrogen Sulfide / Q000627:therapeutic use*; D006973:Hypertension / Q000150:complications*; D007674:Kidney Diseases / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D051379:Mice
chemical_list: D000959:Antihypertensive Agents; D006862:Hydrogen Sulfide
keywords: Blood pressure (BP); Hydrogen sulfide (H(2)S); Hypertension; Hypertensive kidney injury; Sodium hydrosulfide (NaHS)