title: Meta-Analysis of the Long Term Success Rate of Different Interventions in Benign Biliary Strictures.
abstract: BACKGROUND
  Benign biliary stricture is a rare condition and the majority of the cases are caused by operative trauma or chronic inflammation based on various etiology. Although the initial results of endoscopic, percutaneous and surgical treatment are impressive, no comparison about long term stricture resolution is available.
  
  
  OBJECTIVE
  The goal of this study was to compare the long term disease free survival in benign biliary strictures with various etiology after surgery, percutaneous transhepatic-and endoscopic treatment.
  
  
  METHODS
  PubMed, Embase, and Cochrane Library were searched by computer and manually for published studies. The investigators selected the publications according to the inclusion and exclusion criteria, processed the data and assessed the quality of the selected studies. Meta-analysis of data of 24 publications was performed to compare long term disease free survival of different treatment groups.
  
  
  RESULTS
  Compared the subgroups surgery resulted in the highest long term stricture resolution rate, followed by the percutaneous transhepatic treatment, the multiple plastic stent insertion and covered self-expanding metal stents (SEMS), however the difference was not significant. All compared methods are significantly superior to the single plastic stent placement. Long term stricture resolution rate irrespectively of any therapy is still not more than 84%.
  
  
  CONCLUSIONS
  In summary, the use of single plastic stent is not recommended. Further randomized studies and innovative technical development are required for improving the treatment of benign biliary strictures.
authors.affiliation: Semmelweis University, 1st Department of Surgery, Budapest, Hungary.
authors.forename: Orsolya
authors.initials: O
authors.lastname: Huszár
authors.affiliation: Semmelweis University, 1st Department of Surgery, Budapest, Hungary.
authors.forename: Bálint
authors.initials: B
authors.lastname: Kokas
authors.affiliation: Institute of Bioanalysis, University of Pécs, Medical School, Pécs, Hungary.|Institute for Translational Medicine, University of Pécs, Pécs, Hungary.
authors.forename: Péter
authors.initials: P
authors.lastname: Mátrai
authors.affiliation: Institute for Translational Medicine, University of Pécs, Pécs, Hungary.|Division of Translational Medicine, First Department of Medicine, University of Pécs, Pécs, Hungary.|Hungarian Academy of Sciences - University of Szeged, Momentum Gastroenterology Multidisciplinary Research Group, Szeged, Hungary.
authors.forename: Péter
authors.initials: P
authors.lastname: Hegyi
authors.affiliation: Institute for Translational Medicine, University of Pécs, Pécs, Hungary.
authors.forename: Erika
authors.initials: E
authors.lastname: Pétervári
authors.affiliation: Division of Gastroenterology, First Department of Medicine, University of Pécs, Pécs, Hungary.
authors.forename: Áron
authors.initials: Á
authors.lastname: Vincze
authors.affiliation: Division of Gastroenterology, First Department of Medicine, University of Pécs, Pécs, Hungary.
authors.forename: Gabriella
authors.initials: G
authors.lastname: Pár
authors.affiliation: Division of Translational Medicine, First Department of Medicine, University of Pécs, Pécs, Hungary.|Division of Gastroenterology, First Department of Medicine, University of Pécs, Pécs, Hungary.
authors.forename: Patrícia
authors.initials: P
authors.lastname: Sarlós
authors.affiliation: Division of Translational Medicine, First Department of Medicine, University of Pécs, Pécs, Hungary.|Division of Gastroenterology, First Department of Medicine, University of Pécs, Pécs, Hungary.
authors.forename: Judit
authors.initials: J
authors.lastname: Bajor
authors.affiliation: Division of Gastroenterology, First Department of Medicine, University of Pécs, Pécs, Hungary.
authors.forename: József
authors.initials: J
authors.lastname: Czimmer
authors.affiliation: Division of Translational Medicine, First Department of Medicine, University of Pécs, Pécs, Hungary.|1st Department of Paediatrics, Semmelweis University, Budapest, Hungary.
authors.forename: Dóra
authors.initials: D
authors.lastname: Mosztbacher
authors.affiliation: Institute for Translational Medicine, University of Pécs, Pécs, Hungary.
authors.forename: Katalin
authors.initials: K
authors.lastname: Márta
authors.affiliation: Institute for Translational Medicine, University of Pécs, Pécs, Hungary.
authors.forename: Csaba
authors.initials: C
authors.lastname: Zsiborás
authors.affiliation: Institute for Translational Medicine, University of Pécs, Pécs, Hungary.
authors.forename: Péter
authors.initials: P
authors.lastname: Varjú
authors.affiliation: Semmelweis University, 1st Department of Surgery, Budapest, Hungary.|Institute for Translational Medicine, University of Pécs, Pécs, Hungary.
authors.forename: Ákos
authors.initials: Á
authors.lastname: Szücs
mesh_terms: D001660:Biliary Tract Diseases / Q000473:pathology / Q000601:surgery*; D003251:Constriction, Pathologic; D018572:Disease-Free Survival; D004724:Endoscopy / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D011183:Postoperative Complications; D000069322:Self Expandable Metallic Stents / Q000009:adverse effects