title: Predicting the Impact of Intervention Strategies for Sleeping Sickness in Two High-Endemicity Health Zones of the Democratic Republic of Congo.
abstract: Two goals have been set for Gambian human African trypanosomiasis (HAT), the first is to achieve elimination as a public health problem in 90% of foci by 2020, and the second is to achieve zero transmission globally by 2030. It remains unclear if certain HAT hotspots could achieve elimination as a public health problem by 2020 and, of greater concern, it appears that current interventions to control HAT in these areas may not be sufficient to achieve zero transmission by 2030. A mathematical model of disease dynamics was used to assess the potential impact of changing the intervention strategy in two high-endemicity health zones of Kwilu province, Democratic Republic of Congo. Six key strategies and twelve variations were considered which covered a range of recruitment strategies for screening and vector control. It was found that effectiveness of HAT screening could be improved by increasing effort to recruit high-risk groups for screening. Furthermore, seven proposed strategies which included vector control were predicted to be sufficient to achieve an incidence of less than 1 reported case per 10,000 people by 2020 in the study region. All vector control strategies simulated reduced transmission enough to meet the 2030 goal, even if vector control was only moderately effective (60% tsetse population reduction). At this level of control the full elimination threshold was expected to be met within six years following the start of the change in strategy and over 6000 additional cases would be averted between 2017 and 2030 compared to current screening alone. It is recommended that a two-pronged strategy including both enhanced active screening and tsetse control is implemented in this region and in other persistent HAT foci to ensure the success of the control programme and meet the 2030 elimination goal for HAT.
authors.affiliation: Warwick Infectious Disease Epidemiology Research (WIDER), The University of Warwick, Coventry, UK.|Life Sciences, The University of Warwick, Coventry, UK.
authors.forename: Kat S
authors.identifier: 0000-0001-8414-7648
authors.initials: KS
authors.lastname: Rock
authors.affiliation: Warwick Infectious Disease Epidemiology Research (WIDER), The University of Warwick, Coventry, UK.|Department of Vector Biology, Liverpool School of Tropical Medicine, Liverpool, UK.
authors.forename: Steve J
authors.initials: SJ
authors.lastname: Torr
authors.affiliation: Programme National de Lutte contre la Trypanosomiase Humaine Africaine (PNLTHA), Kinshasa, Democratic Republic of Congo.
authors.forename: Crispin
authors.initials: C
authors.lastname: Lumbala
authors.affiliation: Warwick Infectious Disease Epidemiology Research (WIDER), The University of Warwick, Coventry, UK.|Life Sciences, The University of Warwick, Coventry, UK.|Mathematics Institute, The University of Warwick, Coventry, UK.
authors.forename: Matt J
authors.initials: MJ
authors.lastname: Keeling
mesh_terms: D000818:Animals; D015023:Democratic Republic of the Congo / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D007303:Insect Vectors / Q000469:parasitology / Q000502:physiology; D014345:Trypanosoma / Q000502:physiology; D014353:Trypanosomiasis, African / Q000453:epidemiology* / Q000469:parasitology / Q000635:transmission; D014370:Tsetse Flies / Q000469:parasitology / Q000502:physiology