title: Preliminary investigation of whole-pancreas 3D histogram ADC metrics for predicting progression of acute pancreatitis.
abstract: OBJECTIVE
  To evaluate whole-pancreas 3D-histogram ADC metrics in acute pancreatitis.
  
  
  METHODS
  In 41 patients with acute pancreatitis undergoing MRI/MRCP with DWI, 3D-volumes-of-interest encompassing the entire pancreas were placed to derive whole-pancreas histogram ADC metrics.
  
  
  RESULTS
  There were trends toward higher 0-10th percentile ADC, higher 10-25th percentile ADC, lower skewness, and higher kurtosis in patients with new complications (p=0.065-0.095). Conventional mean ADC showed no association with new complications (p=0.203). Kurtosis had highest area-under-the-curve (0.784) for predicting new complications (sensitivity=75.0%; specificity=91.9%).
  
  
  CONCLUSIONS
  Findings suggest whole-pancreas histogram ADC metrics assist early management of acute pancreatitis, (e.g., patient selection for more intensive monitoring/intervention).
authors.affiliation: Department of Radiology, NYU School of Medicine, NYU Langone Medical Center, 660 First Avenue, New York, NY 10016, United States. Electronic address: Amir.Iranmahboob@nyumc.org.
authors.forename: Amir K
authors.initials: AK
authors.lastname: Iranmahboob
authors.affiliation: Department of Radiology, NYU School of Medicine, NYU Langone Medical Center, 660 First Avenue, New York, NY 10016, United States. Electronic address: siobhan.kierans@gmail.com.
authors.forename: Andrea S
authors.initials: AS
authors.lastname: Kierans
authors.affiliation: Department of Radiology, NYU School of Medicine, NYU Langone Medical Center, 660 First Avenue, New York, NY 10016, United States. Electronic address: Chenchan.Huang@nyumc.org.
authors.forename: Chenchan
authors.initials: C
authors.lastname: Huang
authors.affiliation: Department of Radiology, NYU School of Medicine, NYU Langone Medical Center, 660 First Avenue, New York, NY 10016, United States. Electronic address: Justin.ream@nyumc.org.
authors.forename: Justin M
authors.initials: JM
authors.lastname: Ream
authors.affiliation: Department of Radiology, NYU School of Medicine, NYU Langone Medical Center, 660 First Avenue, New York, NY 10016, United States. Electronic address: Andrew.Rosenkrantz@nyumc.org.
authors.forename: Andrew B
authors.initials: AB
authors.lastname: Rosenkrantz
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D038524:Diffusion Magnetic Resonance Imaging; D018450:Disease Progression; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000000981:diagnostic imaging*; D010195:Pancreatitis / Q000000981:diagnostic imaging*; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D055815:Young Adult
keywords: Acute pancreatitis; Apparent diffusion coefficient; Diffusion-weighted imaging; MRI