title: 2-Methacryloyloxyethyl Phosphorylcholine Polymer Treatment of Complete Dentures to Inhibit Denture Plaque Deposition.
abstract: Removable dentures made of poly (methyl methacrylate) (PMMA) are prone to bacterial adherence and dental plaque formation, which is called denture plaque. Denture plaque-associated infection is a source of serious dental and medical complications in the elderly. 2-Methacryloyloxyethyl phosphorylcholine (MPC) is a well-known biomedical material that exhibits marked antithrombogenicity and tissue compatibility because of its high resistance to protein adsorption and cell adhesion. Therefore, MPC polymer coatings are suggested to have the potential to inhibit plaque deposition on the surface of PMMA dentures. However, coating MPC polymer on the surface of a PMMA denture is a complex procedure that requires specialized equipment, which is regarded as a major barrier to its clinical application. Here, we introduce a new MPC polymer treatment procedure that uses poly (MPC-co-BMA-co-MPAz) (PMBPAz) to prevent denture plaque deposition on removable dentures. This procedure enables the MPC coating of PMMA denture surfaces in a simple and stable manner that is resistant to various chemical and mechanical stresses due to the MPC layer of PMBPAz that is covalently bound to the PMMA surface by ultraviolet light irradiation. In addition, the procedure does not require any specialized equipment and can be completed by clinicians within 2 min. We applied this procedure in a clinical setting and demonstrated its clinical utility and efficacy in inhibiting plaque deposition on removable dentures.
authors.affiliation: Department of Prosthodontics, School of Dentistry, Showa University.
authors.forename: Kenji
authors.initials: K
authors.lastname: Ikeya
authors.affiliation: Department of Prosthodontics, School of Dentistry, Showa University.
authors.forename: Miya
authors.initials: M
authors.lastname: Fukunishi
authors.affiliation: Department of Prosthodontics, School of Dentistry, Showa University.
authors.forename: Fuminori
authors.initials: F
authors.lastname: Iwasa
authors.affiliation: Department of Materials Engineering, School of Engineering, The University of Tokyo.
authors.forename: Yuuki
authors.initials: Y
authors.lastname: Inoue
authors.affiliation: Department of Materials Engineering, School of Engineering, The University of Tokyo.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Ishihara
authors.affiliation: Department of Prosthodontics, School of Dentistry, Showa University; kazuyoshi@dent.showa-u.ac.jp.
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Baba
mesh_terms: D000327:Adsorption; D001672:Biocompatible Materials / Q000737:chemistry; D003773:Dental Plaque / Q000517:prevention & control*; D003824:Denture, Complete; D006801:Humans; D008689:Methacrylates / Q000737:chemistry*; D010767:Phosphorylcholine / Q000031:analogs & derivatives* / Q000737:chemistry; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D008689:Methacrylates; D010767:Phosphorylcholine; C070638:2-methacryloyloxyethyl phosphorylcholine