title: Sepsis and siderosis, Yersinia enterocolitica and hereditary haemochromatosis.
abstract: A 60-year-old woman was admitted with sepsis, relative bradycardia, CT evidence of numerous small liver abscesses and 'skin bronzing' consistent with hereditary haemochromatosis (HH). Yersinia enterocolitica O:9 infection was confirmed by serology specimens taken 10 days apart. Iron overload was detected, and homozygous C282Y gene mutation confirmed HH. Liver biopsy revealed grade IV siderosis with micronodular cirrhosis. Haemochromatosis is a common, inherited disorder leading to iron overload that can produce end-organ damage from excess iron deposition. Haemochromatosis diagnosis allowed aggressive medical management with phlebotomy achieving normalisation of iron stores. Screening for complications of cirrhosis was started that included hepatoma surveillance. Iron overload states are known to increase patient susceptibility to infections caused by lower virulence bacteria lacking sophisticated iron metabolism pathways, for example, Yersinia enterocolitica Although these serious disseminated infections are rare, they may serve as markers for occult iron overload and should prompt haemochromatosis screening.
authors.affiliation: Department of Victorian Liver Transplant Unit, Austin Health, Heidelberg, Victoria, Australia.
authors.forename: Phoebe A
authors.initials: PA
authors.lastname: Thwaites
authors.affiliation: Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.
authors.forename: Marion L
authors.identifier: http://orcid.org/0000-0003-1094-9853
authors.initials: ML
authors.lastname: Woods
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D005260:Female; D006432:Hemochromatosis / Q000235:genetics*; D006486:Hemosiderosis / Q000150:complications; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications / Q000000981:diagnostic imaging; D008875:Middle Aged; D009894:Opportunistic Infections / Q000150:complications*; D018805:Sepsis / Q000150:complications*; D014057:Tomography, X-Ray Computed; D015009:Yersinia Infections / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy; D015008:Yersinia enterocolitica
chemical_list: D000900:Anti-Bacterial Agents