title: Antithrombotic Protein Filter Composed of Hybrid Tissue-Fabric Material has a Long Lifetime.
abstract: There are recent reports of hybrid tissue-fabric materials with good performance-high biocompatibility and high mechanical strength. In this study, we demonstrate the capability of a hybrid material as a long-term filter for blood proteins. Polyester fabrics were implanted into rats to fabricate hybrid tissue-fabric material sheets. The hybrid materials comprised biological tissue grown on the fabric. The materials were extracted from the rat's body, approximately 100 days post-implantation. The tissues were decellularized to prevent immunological rejection. An antithrombogenicity test was performed by dropping blood onto the hybrid material surface. The hybrid material showed lesser blood coagulation than polysulfone and cellulose. Blood plasma was filtered using the hybrid material to evaluate the protein removal percentage and the lifetime of the hybrid material in vitro. The hybrid material showed a comparable performance to conventional filters for protein removal. Moreover, the hybrid material could work as a protein filter for 1 month, which is six times the lifetime of polysulfone.
authors.affiliation: Department of Electrical Engineering and Information Systems, Graduate School of Engineering, The University of Tokyo, Tokyo, 113-8656, Japan.|Department of Biomedical Engineering, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-0033, Japan.|Department of Medical Engineering and Cardiology, Institute of Development, Aging and Cancer, Tohoku University, Miyagi, 980-8575, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Inoue
authors.affiliation: Department of Electrical Engineering and Information Systems, Graduate School of Engineering, The University of Tokyo, Tokyo, 113-8656, Japan.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Yokota
authors.affiliation: Department of Electrical Engineering and Information Systems, Graduate School of Engineering, The University of Tokyo, Tokyo, 113-8656, Japan.|The Institute of Scientific and Industrial Research (ISIR), Osaka University, Osaka, 567-0047, Japan.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Sekitani
authors.affiliation: Department of Electrical Engineering and Information Systems, Graduate School of Engineering, The University of Tokyo, Tokyo, 113-8656, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Kaneko
authors.affiliation: Department of Electrical Engineering and Information Systems, Graduate School of Engineering, The University of Tokyo, Tokyo, 113-8656, Japan.
authors.forename: Taeseong
authors.initials: T
authors.lastname: Woo
authors.affiliation: Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, Fukuoka, 819-0395, Japan.
authors.forename: Shingo
authors.initials: S
authors.lastname: Kobayashi
authors.affiliation: Department of Biochemical Engineering, Graduate School of Science and Engineering, Yamagata University, Yonezawa, 992-8510, Japan.
authors.forename: Tomokazu
authors.initials: T
authors.lastname: Shibuya
authors.affiliation: Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, Fukuoka, 819-0395, Japan.
authors.forename: Masaru
authors.initials: M
authors.lastname: Tanaka
authors.affiliation: Institute of Fluid Science, Tohoku University, Miyagi, 980-8577, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kosukegawa
authors.affiliation: Department of Biomedical Engineering, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-0033, Japan.
authors.forename: Itsuro
authors.initials: I
authors.lastname: Saito
authors.affiliation: Department of Biomedical Engineering, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-0033, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Isoyama
authors.affiliation: Department of Biomedical Engineering, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-0033, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Abe
authors.affiliation: Department of Medical Engineering and Cardiology, Institute of Development, Aging and Cancer, Tohoku University, Miyagi, 980-8575, Japan.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Yambe
authors.affiliation: Department of Electrical Engineering and Information Systems, Graduate School of Engineering, The University of Tokyo, Tokyo, 113-8656, Japan.
authors.forename: Takao
authors.initials: T
authors.lastname: Someya
authors.affiliation: Department of Electrical Engineering and Information Systems, Graduate School of Engineering, The University of Tokyo, Tokyo, 113-8656, Japan. sekino@bee.t.u-tokyo.ac.jp.
authors.forename: Masaki
authors.initials: M
authors.lastname: Sekino
mesh_terms: D001777:Blood Coagulation; D002482:Cellulose / Q000737:chemistry; D005343:Fibrinolytic Agents / Q000737:chemistry*; D006801:Humans; D008567:Membranes, Artificial; D011091:Polyesters / Q000737:chemistry*; D011100:Polyglycolic Acid / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D013450:Sulfones / Q000737:chemistry
chemical_list: D005343:Fibrinolytic Agents; D008567:Membranes, Artificial; D011091:Polyesters; D011108:Polymers; D013450:Sulfones; C020542:velour; C017662:polysulfone P 1700; D011100:Polyglycolic Acid; D002482:Cellulose
keywords: Blood coagulation; Decellularization; Glucose sensor; Protein filter; Scaffold