title: Effects of exercise and lifestyle intervention on oxidative stress in chronic kidney disease.
abstract: OBJECTIVE
  Determine the effects of a 12-month exercise and lifestyle intervention program on changes in plasma biomarkers of oxidative stress in pre-dialysis chronic kidney disease (CKD) patients.
  
  
  METHODS
  A total of 136 stage 3-4 CKD patients were randomized to receive standard nephrological care with (N = 72) or without (N = 64) a lifestyle and exercise intervention for 12 months. Plasma total F2-isoprostanes (IsoP), glutathione peroxidase (GPX) activity, total antioxidant capacity (TAC), anthropometric and biochemical data were collected at baseline and at 12 months.
  
  
  RESULTS
  There were no significant differences between groups at baseline. There were no significant differences in changes for standard care and lifestyle intervention, respectively, in IsoP (p = 0.88), GPX (p = 0.87), or TAC (p = 0.56). Patients identified as having high IsoP at baseline (>250 pg/mL) had a greater decrease in IsoP with lifestyle intervention compared to standard care; however, the difference was not statistically significant (p = 0.06). There was no difference in the change in kidney function (eGFR) between standard care and lifestyle intervention (p = 0.33).
  
  
  CONCLUSIONS
  Exercise and lifestyle modification in stage 3-4 CKD did not produce changes in systemic biomarkers of oxidative stress over a 12-month period, but patients with high IsoP may benefit most from the addition of intervention to standard care.
authors.affiliation: a Centre for Kidney Disease Research, School of Medicine , The University of Queensland, Translational Research Institute , Brisbane , Australia.
authors.forename: David M
authors.initials: DM
authors.lastname: Small
authors.affiliation: b School of Human Movement and Nutrition Sciences , The University of Queensland , Brisbane , Australia.
authors.forename: Kassia S
authors.initials: KS
authors.lastname: Beetham
authors.affiliation: b School of Human Movement and Nutrition Sciences , The University of Queensland , Brisbane , Australia.
authors.forename: Erin J
authors.initials: EJ
authors.lastname: Howden
authors.affiliation: b School of Human Movement and Nutrition Sciences , The University of Queensland , Brisbane , Australia.
authors.forename: David R
authors.initials: DR
authors.lastname: Briskey
authors.affiliation: a Centre for Kidney Disease Research, School of Medicine , The University of Queensland, Translational Research Institute , Brisbane , Australia.|c Department of Nephrology , Princess Alexandra Hospital , Brisbane , Australia.
authors.forename: David W
authors.initials: DW
authors.lastname: Johnson
authors.affiliation: a Centre for Kidney Disease Research, School of Medicine , The University of Queensland, Translational Research Institute , Brisbane , Australia.|c Department of Nephrology , Princess Alexandra Hospital , Brisbane , Australia.
authors.forename: Nicole M
authors.initials: NM
authors.lastname: Isbel
authors.affiliation: a Centre for Kidney Disease Research, School of Medicine , The University of Queensland, Translational Research Institute , Brisbane , Australia.
authors.forename: Glenda C
authors.initials: GC
authors.lastname: Gobe
authors.affiliation: b School of Human Movement and Nutrition Sciences , The University of Queensland , Brisbane , Australia.
authors.forename: Jeff S
authors.initials: JS
authors.lastname: Coombes
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000032:analysis; D015415:Biomarkers / Q000032:analysis*; D016022:Case-Control Studies; D005081:Exercise Therapy; D005260:Female; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D051436:Renal Insufficiency, Chronic / Q000503:physiopathology / Q000628:therapy*; D055815:Young Adult
chemical_list: D000975:Antioxidants; D015415:Biomarkers
keywords: Chronic kidney disease; exercise and lifestyle modification; oxidative stress