title: Establishing the standard method of cochlear implant in Rongchang pig.
abstract: CONCLUSIONS
  In this investigation, a large mammal, Rongchang pigs were used to successfully establish a research platform for cochlear implant study on the routine use of it in clinic.
  
  
  OBJECTIVE
  The aim of this study was to establish a standard method of cochlear implant in a large mammal-pig.
  
  
  METHODS
  Rongchang pigs were selected, then divided into two groups: normal-hearing group (Mitf +/+) and mutation group with hearing loss (Mitf -/-). Cochlear implants were used and ABR and EABR were recorded. The implanted electrodes were observed by X-ray and HE stains.
  
  
  RESULTS
  The success with cochlear implant and the best electrode position could be defined in all animals, the coiling of the cochlea reached 1.5-1.75 turns. Immediately after the operation of cochlear implants, the ABR threshold of the operated ear (right) could not be derived for each frequency at 120 dB SPL. Moreover, 7 days after surgery, the low-frequency ABR threshold of the operated ear (right) could be derived partly at 100 dB SPL, but the high-frequency ABR threshold could not be derived at 120 dB SPL. Immediately or 1 week after cochlear implants, the EABR threshold was 90 CL in the Mitf +/+ group. This was obviously lower than the 190 CL in the Mitf -/- group.
authors.affiliation: a Department of Otolaryngology, Head & Neck Surgery , Institute of Otolaryngology, Chinese PLA General Hospital , Beijing, PR China.|b Department of Otolaryngology , Chinese PLA General Hospital of Air Force , Beijing, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.affiliation: c Department of Otolaryngology, Head & Neck Surgery , Beijing Tsinghua Changgung Hospital, Tsinghua University , Beijing, PR China.
authors.forename: Haijin
authors.initials: H
authors.lastname: Yi
authors.affiliation: d Key Laboratory of Pig Industry Sciences (Ministry of Agriculture) , Chongqing Academy of Animal Science , Chongqing, PR China.
authors.forename: Liang
authors.initials: L
authors.lastname: Zhang
authors.affiliation: a Department of Otolaryngology, Head & Neck Surgery , Institute of Otolaryngology, Chinese PLA General Hospital , Beijing, PR China.
authors.forename: Fei
authors.initials: F
authors.lastname: Ji
authors.affiliation: a Department of Otolaryngology, Head & Neck Surgery , Institute of Otolaryngology, Chinese PLA General Hospital , Beijing, PR China.
authors.forename: Shuolong
authors.initials: S
authors.lastname: Yuan
authors.affiliation: a Department of Otolaryngology, Head & Neck Surgery , Institute of Otolaryngology, Chinese PLA General Hospital , Beijing, PR China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: a Department of Otolaryngology, Head & Neck Surgery , Institute of Otolaryngology, Chinese PLA General Hospital , Beijing, PR China.
authors.forename: Lili
authors.initials: L
authors.lastname: Ren
authors.affiliation: a Department of Otolaryngology, Head & Neck Surgery , Institute of Otolaryngology, Chinese PLA General Hospital , Beijing, PR China.
authors.forename: Jianan
authors.initials: J
authors.lastname: Li
authors.affiliation: d Key Laboratory of Pig Industry Sciences (Ministry of Agriculture) , Chongqing Academy of Animal Science , Chongqing, PR China.
authors.forename: Lei
authors.initials: L
authors.lastname: Chen
authors.affiliation: a Department of Otolaryngology, Head & Neck Surgery , Institute of Otolaryngology, Chinese PLA General Hospital , Beijing, PR China.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Guo
authors.affiliation: a Department of Otolaryngology, Head & Neck Surgery , Institute of Otolaryngology, Chinese PLA General Hospital , Beijing, PR China.
authors.forename: Shiming
authors.initials: S
authors.lastname: Yang
mesh_terms: D000818:Animals; D001299:Audiometry; D003051:Cochlea / Q000601:surgery; D019929:Cochlear Implantation / Q000379:methods*; D003054:Cochlear Implants; D005260:Female; D008297:Male; D013552:Swine / Q000601:surgery*
keywords: ABR; Cochlear implant; EABR; Rongchang pig