title: [Correlation of FibroTouch and FibroScan with the stage of primary biliary cirrhosis].
abstract: Objective:To investigate the diagnostic value of FibroTouch and FibroScan for the stage of primary biliary cirrhosis (PBC).Methods:A total of 66 PBC patients who visited our hospital from January 2014 to March 2016 were enrolled, and all the patients underwent liver biopsy and FibroTouch and FibroScan tests. Liver stiffness measurement (LSM) was used to assess fibrosis degree, and the receiver operating characteristic (ROC) curve was used to compare the cut-off values, sensitivities, and specificities of these two methods in determining fibrosis stage. The Spearman rank correlation test was used to investigate the correlation between FibroTouch and FibroScan values.Results:The correlation coefficients between FibroTouch or FibroScan values and fibrosis stage determined by liver biopsy were 0.904 and 0.880, respectively (bothP< 0.01). The cut-off values of FibroTouch in the diagnosis of PBC with fibrosis stages of ≥S1, ≥S2, ≥S3, and ≥S4 were 6.25 kPa, 9.05 kPa, 11.75 kPa, and 18.95 kPa, respectively, with sensitivities of 89.7%, 94.7%, 80.0%, and 80.0% and specificities of 100%, 100%, 87.0%, and 100%, respectively; the cut-off values of FibroScan were 6.05 kPa, 8.85 kPa, 12.40 kPa, and 16.20 kPa, respectively, with sensitivities of 96.4%, 88.6%, 76.2%, and 100% and specificities of 77.8%, 100%, 86.4%, and 93.0%, respectively. There were no significant differences in the diagnostic performance between FibroTouch and FibroScan in determining fibrosis stage [≥S1 (P= 0.109), ≥S2 (P= 0.853), ≥S3 (P= 0.387), ≥S4 (P= 0.224)].Conclusion:FibroTouch and FibroScan can be used as noninvasive diagnostic tools for the determination of fibrosis stage and the monitoring of disease progression in PBC patients and have good sensitivity and specificity.
authors.affiliation: Department of Traditional and Western Medical Hepatology, Third Hospital of Hebei Medical University, Shijiazhuang, 050051, China.
authors.forename: Y G
authors.initials: YG
authors.lastname: Zhang
authors.affiliation: Department of Traditional and Western Medical Hepatology, Third Hospital of Hebei Medical University, Shijiazhuang, 050051, China.
authors.forename: S X
authors.initials: SX
authors.lastname: Zhao
authors.affiliation: Department of Pathology and Hepatology Institution, Beijing 302 Hospital, Beijing 100039, China.
authors.forename: G D
authors.initials: GD
authors.lastname: Zhou
authors.affiliation: Department of Traditional and Western Medical Hepatology, Third Hospital of Hebei Medical University, Shijiazhuang, 050051, China.
authors.forename: W C
authors.initials: WC
authors.lastname: Li
authors.affiliation: Department of Traditional and Western Medical Hepatology, Third Hospital of Hebei Medical University, Shijiazhuang, 050051, China.
authors.forename: W G
authors.initials: WG
authors.lastname: Ren
authors.affiliation: Department of Traditional and Western Medical Hepatology, Third Hospital of Hebei Medical University, Shijiazhuang, 050051, China.
authors.forename: H J
authors.initials: HJ
authors.lastname: Du
authors.affiliation: Department of Traditional and Western Medical Hepatology, Third Hospital of Hebei Medical University, Shijiazhuang, 050051, China.
authors.forename: R Q
authors.initials: RQ
authors.lastname: Wang
authors.affiliation: Department of Traditional and Western Medical Hepatology, Third Hospital of Hebei Medical University, Shijiazhuang, 050051, China.
authors.forename: Y M
authors.initials: YM
authors.lastname: Nan
mesh_terms: D000328:Adult; D001706:Biopsy; D018450:Disease Progression; D054459:Elasticity Imaging Techniques / Q000295:instrumentation* / Q000379:methods*; D005260:Female; D019694:Hepatitis B, Chronic / Q000503:physiopathology*; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging* / Q000473:pathology; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging* / Q000473:pathology; D008105:Liver Cirrhosis, Biliary; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012372:ROC Curve; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index