title: Exploring the Underlying Genetics of Craniofacial Morphology through Various Sources of Knowledge.
abstract: The craniofacial complex is the billboard of sorts containing information about sex, health, ancestry, kinship, genes, and environment. A thorough knowledge of the genes underlying craniofacial morphology is fundamental to understanding craniofacial biology and evolution. These genes can also provide an important foundation for practical efforts like predicting faces from DNA and phenotype-based facial diagnostics. In this work, we focus on the various sources of knowledge regarding the genes that affect patterns of craniofacial development. Although tremendous successes recently have been made using these sources in both methodology and biology, many challenges remain. Primary among these are precise phenotyping techniques and efficient modeling methods.
authors.affiliation: Department of Neurosciences, Experimental Otorhinolaryngology, KU Leuven, Herestraat 49, P.O. Box 721, 3000 Leuven, Belgium.
authors.forename: Jasmien
authors.initials: J
authors.lastname: Roosenboom
authors.affiliation: Department of Neurosciences, Experimental Otorhinolaryngology, KU Leuven, Herestraat 49, P.O. Box 721, 3000 Leuven, Belgium; Multidisciplinary Cleft Lip and Palate Team, UZ Leuven, Kapucijnenvoer 33, 3000 Leuven, Belgium; Department of Otorhinolaryngology, Head and Neck Surgery, Kapucijnenvoer 33, 3000 Leuven, Belgium.
authors.forename: Greet
authors.initials: G
authors.lastname: Hens
authors.affiliation: Department of Anthropology, Penn State University, 409 Carpenter Building, University Park, PA 16802, USA.
authors.forename: Brooke C
authors.initials: BC
authors.lastname: Mattern
authors.affiliation: Department of Anthropology, Penn State University, 409 Carpenter Building, University Park, PA 16802, USA.
authors.forename: Mark D
authors.initials: MD
authors.lastname: Shriver
authors.affiliation: Medical Image Computing, ESAT/PSI, Department of Electrical Engineering, KU Leuven, Medical Imaging Research Center, Herestraat 49, P.O. Box 7003, 3000 Leuven, Belgium.
authors.forename: Peter
authors.identifier: 0000-0001-9489-9819
authors.initials: P
authors.lastname: Claes
mesh_terms: D005145:Face / Q000033:anatomy & histology*; D005828:Genetics, Population; D005838:Genotype; D006257:Head / Q000033:anatomy & histology* / Q000254:growth & development; D006801:Humans; D009024:Morphogenesis / Q000235:genetics*; D010641:Phenotype