title: Predictive Value of Serum IFN-γ inducible Protein-10 and IFN-γ/IL-4 Ratio for Liver Fibrosis Progression in CHB Patients.
abstract: Noninvasive serum markers for assessment of liver fibrosis in chronic hepatitis B (CHB) patients have not been well-studied. The present study was to evaluate the predictive value of serum interferon gamma-inducible protein-10 (IP-10/CXCL10) and the interferon (IFN)-γ/interleukin (IL)-4 ratio for liver fibrosis progression in CHB patients. A total of 180 CHB patients were categorized into four groups: no fibrosis, mild fibrosis, moderate fibrosis, and severe fibrosis. Serum and intrahepatic levels of IP-10, IFN-γ, and IL-4 were examined, from which the IFN-γ/IL-4 ratio was calculated. We found that the serum IP-10 levels were positively correlated with the severity of liver fibrosis, whereas the IFN-γ/IL-4 ratio was negatively associated with the progression of hepatic fibrosis. Multivariate logistic regression analysis revealed that the serum IP-10 was an independent predictor for significant fibrosis. For predicting significant fibrosis, the IP-10 cut-off value of 300 ng/mL had a sensitivity of 92.7% and a specificity of 68.6%. When the IP-10 level was combined with the IFN-γ/IL-4 ratio, the specificity and positive predictive value were 93.8% and 94.6%, respectively; thus, the discriminatory ability was much improved. In conclusion, the serum IP-10 level and the IFN-γ/IL-4 ratio have great potential to predict significant fibrosis among CHB patients.
authors.affiliation: Department of Infectious Disease, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
authors.forename: Yadong
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Infectious Disease, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
authors.forename: Weiyan
authors.initials: W
authors.lastname: Yu
authors.affiliation: Department of Infectious Disease, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
authors.forename: Chuan
authors.initials: C
authors.lastname: Shen
authors.affiliation: Department of Infectious Disease, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Infectious Disease, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Infectious Disease, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
authors.affiliation: Department of Infectious Disease, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Sun
authors.affiliation: Division of Liver Disease, The Infectious Disease Hospital of Handan City, Handan, Hebei, China.
authors.forename: Yajuan
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Gastroenterology and Hepatology, The First Hospital of Shijiazhuang City, Shijiazhuang, Hebei, China.
authors.forename: Honghao
authors.initials: H
authors.lastname: Che
authors.affiliation: Department of Infectious Disease, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
authors.forename: Caiyan
authors.initials: C
authors.lastname: Zhao
mesh_terms: D000328:Adult; D054357:Chemokine CXCL10 / Q000097:blood*; D018450:Disease Progression; D005260:Female; D019694:Hepatitis B, Chronic / Q000097:blood*; D006801:Humans / Q000097:blood; D007371:Interferon-gamma / Q000097:blood*; D015847:Interleukin-4 / Q000097:blood*; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008103:Liver Cirrhosis / Q000097:blood* / Q000473:pathology*; D016015:Logistic Models; D008297:Male; D011237:Predictive Value of Tests; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012372:ROC Curve; D012680:Sensitivity and Specificity; D053773:Transforming Growth Factor beta1 / Q000097:blood
chemical_list: D054357:Chemokine CXCL10; D012333:RNA, Messenger; D053773:Transforming Growth Factor beta1; D015847:Interleukin-4; D007371:Interferon-gamma