title: Three new antitumor annonaceous acetogenins from the seeds of Annona squamosa.
abstract: Two new annonaceous acetogenins squamocin P (2) and annosquatin III (3) and one new ACG precursor dieporeticenin B (1) along with five known precursors (4-8) were isolated from the seeds of Annona squamosa. Their structures were ascertained by chemical methods and various spectral evidences. These compounds showed inhibitory effects against three multidrug-resistant (MDR) cancer cell lines. Compound 2 and 3 displayed selective cytotoxicity against SMMC 7721/T (IC500.435 and 1.79 μM) and MCF-7/ADR (IC50values 3.34 and 4.04 μM).
authors.affiliation: a Pharmaceutical Institute , Nanjing University of Chinese Medicine , Nanjing , P.R. China.
authors.forename: Chengyao
authors.initials: C
authors.lastname: Ma
authors.affiliation: a Pharmaceutical Institute , Nanjing University of Chinese Medicine , Nanjing , P.R. China.
authors.forename: Qiwen
authors.initials: Q
authors.lastname: Wang
authors.affiliation: a Pharmaceutical Institute , Nanjing University of Chinese Medicine , Nanjing , P.R. China.
authors.forename: Yeye
authors.initials: Y
authors.lastname: Shi
authors.affiliation: a Pharmaceutical Institute , Nanjing University of Chinese Medicine , Nanjing , P.R. China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Li
authors.affiliation: a Pharmaceutical Institute , Nanjing University of Chinese Medicine , Nanjing , P.R. China.
authors.forename: Xunan
authors.initials: X
authors.lastname: Wang
authors.affiliation: a Pharmaceutical Institute , Nanjing University of Chinese Medicine , Nanjing , P.R. China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
authors.affiliation: a Pharmaceutical Institute , Nanjing University of Chinese Medicine , Nanjing , P.R. China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Chen
authors.affiliation: a Pharmaceutical Institute , Nanjing University of Chinese Medicine , Nanjing , P.R. China.
authors.forename: Jianwei
authors.initials: J
authors.lastname: Chen
mesh_terms: D054378:Acetogenins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D031041:Annona / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D019008:Drug Resistance, Neoplasm / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry; D012639:Seeds / Q000737:chemistry
chemical_list: D054378:Acetogenins; D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; C000624333:annosquatin III; C000624334:dieporeticenin B; C000624332:squamocin P
keywords: Annona squamosa; annonaceous acetogenins; annosquatin III; dieporeticenin B; multidrug-resistant cancer cell lines; squamocin P