title: Evaluation of the effectiveness of low-dose aspirin and omega 3 in treatment of asymmetrically intrauterine growth restriction: A randomized clinical trial.
abstract: To test the effect of aspirin and omega 3 on fetal weight as well as feto-maternal blood flow in asymmetrical intrauterine growth restriction (IUGR).
  
  
  
  This study is a clinically registered (NCT02696577), open, parallel, randomized controlled trial, conducted at Assiut Woman's Health Hospital, Egypt including 80 pregnant women (28-30 weeks) with IUGR. They were randomized either to group I: aspirin or group II: aspirin plus omega 3. The primary outcome was the fetal weight after 6 weeks of treatment. Secondary outcomes included Doppler blood flow changes in both uterine and umbilical arteries, birth weight, time and method of delivery and admission to NICU. The outcome variables were analyzed using paired and unpaired t-test.
  
  
  
  The estimated fetal weight increased significant in group II more than group I (p=0.00). The uterine and umbilical arteries blood flow increased significantly in group II (p<0.05). The birth weight in group II was higher than that observed in group I (p<0.05).
  
  
  
  The using of aspirin with omega 3 is more effective than using aspirin only in increasing fetal weight and improving utero-placental blood flow in IUGR.
authors.affiliation: Department of Obstetrics & Gynecology, Woman's Health Hospital, Faculty of Medicine, Assiut University, Egypt. Electronic address: m_khairy2001@yahoo.com.
authors.forename: Mohammed K
authors.initials: MK
authors.lastname: Ali
authors.affiliation: Department of Obstetrics & Gynecology, Hurghada Hospital, Egypt.
authors.forename: Maggy E
authors.initials: ME
authors.lastname: Amin
authors.affiliation: Department of Obstetrics & Gynecology, Woman's Health Hospital, Faculty of Medicine, Assiut University, Egypt.
authors.forename: Ahmed F
authors.initials: AF
authors.lastname: Amin
authors.affiliation: Department of Obstetrics & Gynecology, Woman's Health Hospital, Faculty of Medicine, Assiut University, Egypt.
authors.forename: Diaa Eldeen M
authors.initials: DEM
authors.lastname: Abd El Aal
mesh_terms: D000328:Adult; D001241:Aspirin / Q000008:administration & dosage*; D015525:Fatty Acids, Omega-3 / Q000627:therapeutic use*; D005260:Female; D005317:Fetal Growth Retardation / Q000188:drug therapy*; D020567:Fetal Weight / Q000187:drug effects; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D006801:Humans; D021041:Placental Circulation / Q000187:drug effects; D011247:Pregnancy; D055815:Young Adult
chemical_list: D015525:Fatty Acids, Omega-3; D005343:Fibrinolytic Agents; D001241:Aspirin
keywords: Aspirin; Fetal weight; Omega 3; Utero-placental blood flow