title: P-wave dispersion and its relationship with the severity of the disease in patients with stable coronary artery disease.
abstract: OBJECTIVE
  P- wave dispersion (PD) is an indicator of inhomogeneous and discontinuous propagation of sinus impulses. In the present study we aimed to investigate the PD and its association with the severity of the disease. in patients with stable coronary artery disease.
  
  
  METHODS
  We prospectively analyzed 60 subjects with coronary artery disease (CAD) and 25 subjects with nor-mal coronary angiograms (control group). The maximum and minimum P-wave duration and PD were measured from the 12-lead surface electrocardiograms. The CAD severity was assessed by the severity score (Gensini score) and the number of vessels involved (vessel score).
  
  
  RESULTS
  P max was longer in CAD group compared with the control group (p<0.001). PD was greater in the CAD group, compared with the control group (p<0.001). However, P min did not differ between the two groups. In bi-variate correlation, increased PD was correlated with presence of diabetes mellitus (r=0.316, p=0.014), smoking (r=0.348, p=0.006), left ventricular ejection fraction (r=-0.372, p=0.003), vessel score (r=0.848, p=0.001), and Gensini score (r=0.825, p=0.001). Multiple linear regression analysis showed that PD was independently associ¬ated with vessel score ((3=0.139, p=0.002) and Gensini score ((3=0.132, p=0.007).
  
  
  CONCLUSIONS
  PD was greater in patients with CAD than in controls and it was associated with CAD severity.
authors.affiliation: Department of Cardiology, Mugla Sitki Kocman University School of Medicine, Mugla, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Akin
authors.affiliation: Department of Cardiology, Istanbul University Institute of Cardiology, Istanbul, Turkey.
authors.forename: Inci
authors.initials: I
authors.lastname: Firatli
authors.affiliation: Department of Cardiology, Istanbul University Institute of Cardiology, Istanbul, Turkey.
authors.forename: Fahrettin
authors.initials: F
authors.lastname: Katkat
authors.affiliation: Department of Cardiology, Istanbul University Institute of Cardiology, Istanbul, Turkey.
authors.forename: Tevfik
authors.initials: T
authors.lastname: Gurmen
authors.affiliation: Department of Cardiology, Istanbul University Institute of Cardiology, Istanbul, Turkey.
authors.forename: Burak
authors.initials: B
authors.lastname: Ayca
authors.affiliation: Department of Cardiology, Istanbul University Institute of Cardiology, Istanbul, Turkey.
authors.forename: Muhsin
authors.initials: M
authors.lastname: Kalyoncuoglu
authors.affiliation: Department of Cardiology, Istanbul University Institute of Cardiology, Istanbul, Turkey.
authors.forename: Okay
authors.initials: O
authors.lastname: Abaci
authors.affiliation: Department of Cardiology, Istanbul University Institute of Cardiology, Istanbul, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Sari
authors.affiliation: Department of Cardiology, Istanbul University Institute of Cardiology, Istanbul, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Ersanli
authors.affiliation: Department of Cardiology, Istanbul University Institute of Cardiology, Istanbul, Turkey.
authors.forename: Serdar
authors.initials: S
authors.lastname: Kucukoglu
authors.affiliation: Department of Cardiology, Istanbul University Institute of Cardiology, Istanbul, Turkey.
authors.forename: Zerrin
authors.initials: Z
authors.lastname: Yigit
keywords: Coronary artery disease; P-wave dispersion; gensini score; stable angina pectoris