title: Phytochemical Investigations of Three Rhodocodon (Hyacinthaceae Sensu APG II) Species.
abstract: The genus Rhodocodon (Hyacinthaceae sensu APG II) is endemic to Madagascar, and its phytochemistry has not been described previously. The phytochemistry of three species in this genus has been investigated, and eight compounds, including three bufadienolides (compounds 1, 4, and 5), a norlignan (2), and four homoisoflavonoids (compounds 3 and 6-8), have been isolated and identified. Compounds 1-3 and 6-8 have not been described previously. The COX-2 inhibitory activity of compound 6 and compound 7 acetate (compound 7A) was investigated on isolated colorectal cancer cells. Compounds 6 and 7A inhibited COX-2 by 10% and 8%, respectively, at a concentration of 12.5 μM compared to 12% for 1 mM aspirin (the positive control).
authors.affiliation: Natural Products Research Group, Department of Chemistry, Faculty of Engineering and Physical Sciences, University of Surrey , Guildford, GU2 7XH, United Kingdom.|School of Life Sciences, Pharmacy and Chemistry, Faculty of Science, Engineering and Computing, Kingston University , Penrhyn Road, Kingston Upon Thames, KT1 2EE, United Kingdom.
authors.forename: Sianne
authors.identifier: 0000-0002-7200-927X
authors.initials: S
authors.lastname: Schwikkard
authors.affiliation: Natural Products Research Group, Department of Chemistry, Faculty of Engineering and Physical Sciences, University of Surrey , Guildford, GU2 7XH, United Kingdom.
authors.forename: Alaa
authors.initials: A
authors.lastname: Alqahtani
authors.affiliation: Institute of Plant Sciences, NAWI Graz, Karl-Franzens-University Graz , Holteigasse 6, A-8010, Graz, Austria.
authors.forename: Walter
authors.initials: W
authors.lastname: Knirsch
authors.affiliation: Institute of Plant Sciences, NAWI Graz, Karl-Franzens-University Graz , Holteigasse 6, A-8010, Graz, Austria.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Wetschnig
authors.affiliation: School of Life Sciences, Pharmacy and Chemistry, Faculty of Science, Engineering and Computing, Kingston University , Penrhyn Road, Kingston Upon Thames, KT1 2EE, United Kingdom.
authors.forename: Andrius
authors.initials: A
authors.lastname: Jaksevicius
authors.affiliation: School of Life Sciences, Pharmacy and Chemistry, Faculty of Science, Engineering and Computing, Kingston University , Penrhyn Road, Kingston Upon Thames, KT1 2EE, United Kingdom.
authors.forename: Elizabeth I
authors.initials: EI
authors.lastname: Opara
authors.affiliation: Natural Products Research Group, Department of Chemistry, Faculty of Engineering and Physical Sciences, University of Surrey , Guildford, GU2 7XH, United Kingdom.|School of Chemistry and Physics, University of KwaZulu-Natal , Durban, 4041, South Africa.
authors.forename: Moses K
authors.initials: MK
authors.lastname: Langat
authors.affiliation: Parc Botanique et Zoologique de Tsimbazaza , Rue Kasanga Fernand, Antananarivo 101, Madagascar.
authors.forename: Jackie L
authors.initials: JL
authors.lastname: Andriantiana
authors.affiliation: Natural Products Research Group, Department of Chemistry, Faculty of Engineering and Physical Sciences, University of Surrey , Guildford, GU2 7XH, United Kingdom.|School of Chemistry and Physics, University of KwaZulu-Natal , Durban, 4041, South Africa.
authors.forename: Dulcie A
authors.identifier: 0000-0001-7778-5617
authors.initials: DA
authors.lastname: Mulholland
mesh_terms: D000070357:Asparagaceae / Q000737:chemistry*; D002018:Bufanolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D052246:Cyclooxygenase 2 Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019668:Liliaceae / Q000737:chemistry*; D008270:Madagascar; D015394:Molecular Structure; D064209:Phytochemicals; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: C000621487:3,3'-dimethoxy-4,4'-diacetoxy-7'-ketolignano-9,9'-lactone; C000621486:3beta-(O-beta-D-glucopyranosyl)-14beta-hydroxy-5alpha,19-oxobufa-20,22-dienolid; C554544:5,7-dihydroxy-3-(3-hydroxy-4-methoxybenzyl)chroman-4-one; D002018:Bufanolides; D052246:Cyclooxygenase 2 Inhibitors; D007529:Isoflavones; D007783:Lactones; D017705:Lignans; D064209:Phytochemicals; D010936:Plant Extracts