title: Evaluation of Fundus Blood Flow in Normal Individuals and Patients with Internal Carotid Artery Obstruction Using Laser Speckle Flowgraphy.
abstract: OBJECTIVE
  We investigated whether laser speckle flowgraphy (LSFG) results are comparable in both eyes and whether it is useful in the diagnosis of disparity in ocular ischemic syndrome (OIS) patients.
  
  
  METHODS
  We compared the mean blur rate (MBR) value for various fundus regions in both eyes of 41 healthy subjects and 15 internal carotid artery occlusion (ICAO) cases. We calculated the standard value of the Laterality Index (LI), which was the MBR comparison of both eyes in each of the regions, in the control subjects. We then investigated the correlation between both eyes for the LIs in the entire fundus, the degree of ICAO and visual function.
  
  
  RESULTS
  The disparity of the LIs in both eyes was least in the entire area of the fundus in control subjects and there was a significant correlation between both eyes of the 41 healthy individuals (P = 0.019). Significant correlations were found for the LI, visual acuity and degree of ICAO. The specificity and sensitivity of LI in the entire area was 93.8% and 100%, respectively.
  
  
  CONCLUSIONS
  LSFG revealed normal individuals have symmetrical fundus blood flow. LSFG could detect OIS and might be a useful tool for detecting disparities in fundus blood flow.
authors.affiliation: Department of Ophthalmology, Gunma University School of Medicine, Maebashi, Gunma, Japan.
authors.forename: Yoichiro
authors.initials: Y
authors.lastname: Shinohara
authors.affiliation: Department of Ophthalmology, Gunma University School of Medicine, Maebashi, Gunma, Japan.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Kashima
authors.affiliation: Department of Ophthalmology, Gunma University School of Medicine, Maebashi, Gunma, Japan.
authors.forename: Hideo
authors.initials: H
authors.lastname: Akiyama
authors.affiliation: Department of Ophthalmology, Gunma University School of Medicine, Maebashi, Gunma, Japan.
authors.forename: Yukitoshi
authors.initials: Y
authors.lastname: Shimoda
authors.affiliation: Department of Ophthalmology, Gunma University School of Medicine, Maebashi, Gunma, Japan.
authors.forename: Danjie
authors.initials: D
authors.lastname: Li
authors.affiliation: Department of Ophthalmology, Gunma University School of Medicine, Maebashi, Gunma, Japan.
authors.forename: Shoji
authors.initials: S
authors.lastname: Kishi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015901:Angiography, Digital Subtraction; D001783:Blood Flow Velocity / Q000502:physiology*; D002343:Carotid Artery, Internal / Q000502:physiology*; D005260:Female; D005654:Fundus Oculi; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D017078:Laser-Doppler Flowmetry; D018810:Magnetic Resonance Angiography; D008297:Male; D008833:Microcirculation / Q000502:physiology*; D008875:Middle Aged