title: [Expression of PD-1/PD-L1 in triple-negative breast carcinoma and its significance].
abstract: Objective:To investigate the correlation between the expression of PD-1, PD-L1 and clinicopathologic parameters in triple negative breast carcinoma (TNBC).Methods:Samples from 151 patients with TNBC and 65 cases of other breast carcinomas (non-TNBC) were examined for PD-L1 and PD-1 expression by immunohistochemical staining on tissue microarray.Results:The expression of PD-L1 and PD-1 in the tumor cells and interstitial lymphocytes in TNBC was significantly (P<0.05)higher than that in non-TNBC.In TNBC, the expression rates of PD-L1 in the cancer nests and stroma were 16.6%(25/151) and 25.2%(38/151)respectively.The former was positively correlated with tumor histological grade and lymph node metastasis (P<0.05), and the latter only with tumor histological grade (P<0.05). The expression rate of PD-1 was 27.2% (41/151), and correlated with PD-L1 expression in stromal tumor-infiltrating lymphocytes (P<0.05).Conclusion:The expression of PD-L1 in TNBC is significantly correlated with high-grade histology, lymph node metastasis and PD-L1 expression in stromal tumor-infiltrating lymphocytes.
authors.affiliation: Department of Pathology, Wannan Medical College Yijishan Hospital, Wuhu 241001, China.
authors.forename: W
authors.initials: W
authors.lastname: Zhang
authors.forename: G X
authors.initials: GX
authors.lastname: Xu
authors.forename: J J
authors.initials: JJ
authors.lastname: Li
authors.forename: X
authors.initials: X
authors.lastname: Liu
authors.forename: Y J
authors.initials: YJ
authors.lastname: Chen
authors.forename: F
authors.initials: F
authors.lastname: Zhang
mesh_terms: D060890:B7-H1 Antigen / Q000378:metabolism*; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D016246:Lymphocytes, Tumor-Infiltrating / Q000378:metabolism*; D060787:Neoplasm Grading; D061026:Programmed Cell Death 1 Receptor / Q000378:metabolism*; D064726:Triple Negative Breast Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D060890:B7-H1 Antigen; C105992:PDCD1 protein, human; D061026:Programmed Cell Death 1 Receptor