title: [Malignization of vestibular schwannoma 13 years after radiation therapy].
abstract: This article presents a case of malignant transformation of vestibular schwannoma 13 years after stereotactic radiation therapy, which lead to an acute life-threatening condition. Although the observation is currently only based on case reports, an increasing number of these support the hypothesis that there is a relevant risk of malignant transformation in the long-term course of previously irradiated vestibular schwannomas. Therefore, long-term MRI follow-up should be considered.
authors.affiliation: Universitätsklinik und Poliklinik für Neurochirurgie, Universitätsklinikum Halle (Saale), Ernst-Grube-Straße 40, 06120, Halle (Saale), Deutschland. sebastian.simmermacher@uk-halle.de.
authors.forename: S
authors.initials: S
authors.lastname: Simmermacher
authors.affiliation: Klinik für Strahlentherapie, Universitätsklinikum Halle, Halle (Saale), Deutschland.
authors.forename: D
authors.initials: D
authors.lastname: Vordermark
authors.affiliation: Klinik für Hämatologie und Onkologie, Universitätsklinikum Halle, Halle (Saale), Deutschland.
authors.forename: T
authors.initials: T
authors.lastname: Kegel
authors.affiliation: Universitätsklinik und Poliklinik für Neurochirurgie, Universitätsklinikum Halle (Saale), Ernst-Grube-Straße 40, 06120, Halle (Saale), Deutschland.
authors.forename: C
authors.initials: C
authors.lastname: Strauss
mesh_terms: D002471:Cell Transformation, Neoplastic; D006801:Humans; D008279:Magnetic Resonance Imaging; D009464:Neuroma, Acoustic / Q000601:surgery; D011832:Radiation Injuries; D016634:Radiosurgery
keywords: Malignant peripheral nerve sheath tumor; Malignant transformation; Stereotactic radiotherapy; Vestibular schwannoma