title: High Expression of Stromal Cell-Derived Factor 1 (SDF-1) and NF-κB Predicts Poor Prognosis in Cervical Cancer.
abstract: BACKGROUND SDF-1 and NF-κB are associated with the prognosis of a wide range of cancers, but their value in cervical cancer remains controversial. The aim of this study was to investigate the expression of SDF-1and NF-κB in cervical cancer and their significance in clinical prognosis. MATERIAL AND METHODS The expression of SDF-1and NF-κB in 105 formalin-fixed, paraffin-embedded cervical cancer tissues and the adjacent tissues was examined by immunohistochemistry (IHC). The results were semi-quantitatively scored and analyzed by chi-square test. The overall survival times (OS) were collected by follow-up and analyzed by Kaplan-Meier analysis. RESULTS The expression level of both SDF-1and NF-κB in cervical cancer are higher than that in the adjacent tissues (P<0.05). SDF-1 expression are correlated with tumor size and FIGO histology grade (P<0.05). NF-κB expression are correlated with tumor size and FIGO histology grade, and lymph node metastasis (LNM) status (P<0.05). The patients with a positive expression of SDF-1or NF-κB tended to have much shorter survival time than patients with negative expression. In addition, multivariate Cox regression analysis demonstrated that SDF-1 expression and lymph node metastasis are independent predictors of the OS in cervical cancer patients. CONCLUSIONS The expression of SDF-1 is significantly associated with tumor size and FIGO histology grade. The expression of NF-κB is significantly associated with tumor size, FIGO histology grade, and lymph node metastasis. The positive SDF-1or NF-κB expression is significantly correlated with poor prognosis. These may be valuable biomarkers for the prognosis and the potential therapeutic targets of cervical cancer.
authors.affiliation: Breast Cancer Center, Shanghai East Hospital, Tongji University, Shanghai, China (mainland).
authors.forename: Zhiwang
authors.initials: Z
authors.lastname: Song
authors.affiliation: Breast Cancer Center, Shanghai East Hospital, Tongji University, Shanghai, China (mainland).
authors.forename: Xia
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Breast Cancer Center, Shanghai East Hospital, Tongji University, Shanghai, China (mainland).
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Ye
authors.affiliation: Breast Cancer Center, Shanghai East Hospital, Tongji University, Shanghai, China (mainland).
authors.forename: Chan
authors.initials: C
authors.lastname: Feng
authors.affiliation: Breast Cancer Center, Shanghai East Hospital, Tongji University, Shanghai, China (mainland).
authors.forename: Guang
authors.initials: G
authors.lastname: Yang
authors.affiliation: Breast Cancer Center, Shanghai East Hospital, Tongji University, Shanghai, China (mainland).
authors.forename: Yonglin
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Breast Cancer Center, Shanghai East Hospital, Tongji University, Shanghai, China (mainland).
authors.forename: Yun
authors.initials: Y
authors.lastname: Lin
authors.affiliation: Breast Cancer Center, Shanghai East Hospital, Tongji University, Shanghai, China (mainland).
authors.forename: Chunyan
authors.initials: C
authors.lastname: Dong
mesh_terms: D054377:Chemokine CXCL12 / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D016328:NF-kappa B / Q000378:metabolism*; D011379:Prognosis; D002583:Uterine Cervical Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: C515255:CXCL12 protein, human; D054377:Chemokine CXCL12; D016328:NF-kappa B