title: The Role of Reactive Oxygen Species (ROS) in the Biological Activities of Metallic Nanoparticles.
abstract: Nanoparticles (NPs) possess unique physical and chemical properties that make them appropriate for various applications. The structural alteration of metallic NPs leads to different biological functions, specifically resulting in different potentials for the generation of reactive oxygen species (ROS). The amount of ROS produced by metallic NPs correlates with particle size, shape, surface area, and chemistry. ROS possess multiple functions in cellular biology, with ROS generation a key factor in metallic NP-induced toxicity, as well as modulation of cellular signaling involved in cell death, proliferation, and differentiation. In this review, we briefly explained NP classes and their biomedical applications and describe the sources and roles of ROS in NP-related biological functions in vitro and in vivo. Furthermore, we also described the roles of metal NP-induced ROS generation in stem cell biology. Although the roles of ROS in metallic NP-related biological functions requires further investigation, modulation and characterization of metallic NP-induced ROS production are promising in the application of metallic NPs in the areas of regenerative medicine and medical devices.
authors.affiliation: Department of Stem Cell & Regenerative Biotechnology, Incurable Disease Animal Model and Stem Cell Institute (IDASI), Konkuk University, Gwangjin-gu, Seoul 05029, Korea. ahmed_morsy86@yahoo.com.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Abdal Dayem
authors.affiliation: Department of Stem Cell & Regenerative Biotechnology, Incurable Disease Animal Model and Stem Cell Institute (IDASI), Konkuk University, Gwangjin-gu, Seoul 05029, Korea. kawsersau07@gmail.com.
authors.forename: Mohammed Kawser
authors.initials: MK
authors.lastname: Hossain
authors.affiliation: Department of Stem Cell & Regenerative Biotechnology, Incurable Disease Animal Model and Stem Cell Institute (IDASI), Konkuk University, Gwangjin-gu, Seoul 05029, Korea. soobineey@naver.com.
authors.forename: Soo Bin
authors.initials: SB
authors.lastname: Lee
authors.affiliation: Department of Stem Cell & Regenerative Biotechnology, Incurable Disease Animal Model and Stem Cell Institute (IDASI), Konkuk University, Gwangjin-gu, Seoul 05029, Korea. proproggs@naver.com.
authors.forename: Kyeongseok
authors.initials: K
authors.lastname: Kim
authors.affiliation: Department of Stem Cell & Regenerative Biotechnology, Incurable Disease Animal Model and Stem Cell Institute (IDASI), Konkuk University, Gwangjin-gu, Seoul 05029, Korea. subbroto@konkuk.ac.kr.
authors.forename: Subbroto Kumar
authors.initials: SK
authors.lastname: Saha
authors.affiliation: Department of Stem Cell & Regenerative Biotechnology, Incurable Disease Animal Model and Stem Cell Institute (IDASI), Konkuk University, Gwangjin-gu, Seoul 05029, Korea. slayersgod@nate.com.
authors.forename: Gwang-Mo
authors.initials: GM
authors.lastname: Yang
authors.affiliation: Department of Stem Cell & Regenerative Biotechnology, Incurable Disease Animal Model and Stem Cell Institute (IDASI), Konkuk University, Gwangjin-gu, Seoul 05029, Korea. hyeon.choi24@gmail.com.
authors.forename: Hye Yeon
authors.initials: HY
authors.lastname: Choi
authors.affiliation: Department of Stem Cell & Regenerative Biotechnology, Incurable Disease Animal Model and Stem Cell Institute (IDASI), Konkuk University, Gwangjin-gu, Seoul 05029, Korea. ssangoo@konkuk.ac.kr.
authors.forename: Ssang-Goo
authors.initials: SG
authors.lastname: Cho
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D015374:Biosensing Techniques; D004249:DNA Damage; D016503:Drug Delivery Systems; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000145:classification; D061848:Optical Imaging; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism*; D044968:Regenerative Medicine; D013234:Stem Cells / Q000378:metabolism
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D017382:Reactive Oxygen Species
keywords: cellular signaling; nanoparticles (NPs); reactive oxygen species (ROS); regenerative medicine; stem cells; toxicity