title: ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease.
abstract: As the population ages, neurodegenerative diseases such as Alzheimer's disease (AD) are becoming a significant burden on patients, their families, and health-care systems. Neurodegenerative processes may start up to 15 years before outward signs and symptoms of AD, as evidenced by data from AD patients and mouse models. A major genetic risk factor for late-onset AD is the ɛ4 isoform of apolipoprotein E (ApoE4), which is present in almost 20% of the population. In this review we discuss the contribution of ApoE receptor signaling to the function of each component of the tripartite synapse - the axon terminal, the postsynaptic dendritic spine, and the astrocyte - and examine how these systems fail in the context of ApoE4 and AD.
authors.affiliation: Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Center for Translational Neurodegeneration Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: Courtney.Lane@utsouthwestern.edu.
authors.forename: Courtney
authors.initials: C
authors.lastname: Lane-Donovan
authors.affiliation: Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Center for Translational Neurodegeneration Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Center for Neuroscience, Department of Neuroanatomy, Albert Ludwig University, Freiburg, Germany. Electronic address: Joachim.Herz@utsouthwestern.edu.
authors.forename: Joachim
authors.initials: J
authors.lastname: Herz
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D001057:Apolipoproteins E / Q000235:genetics / Q000378:metabolism*; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D026503:Low Density Lipoprotein Receptor-Related Protein-1 / Q000235:genetics / Q000378:metabolism*; D008297:Male; D000091042:Reelin Protein; D013569:Synapses / Q000235:genetics / Q000378:metabolism*
chemical_list: D001057:Apolipoproteins E; D026503:Low Density Lipoprotein Receptor-Related Protein-1; D000091042:Reelin Protein; C000717127:RELN protein, human; C000717128:Reln protein, mouse
keywords: LRP; NMDA receptor; Reelin.; calcium homeostasis; dendrite; endosome; synaptic dysfunction