title: A one-pot synthesis of [1,2,3]triazolo[1,5-a]quinoxalines from 1-azido-2-isocyanoarenes with high bond-forming efficiency.
abstract: An efficient approach to prepare 1,2,3-triazolo[1,5-a]quinoxaline scaffolds, starting from 1-azido-2-isocyanoarenes and terminal acetylenes or substituted acetaldehydes, has been developed. In the case of trifluoromethylation triggered cyclization, four chemical bonds, including two C-C and two C-N bonds, were formed consecutively without isolating the triazole intermediate. In addition, these triazo-fused products were readily transformed into diversified quinoxaline derivatives via rhodium-catalyzed carbenoid insertion reactions.
authors.affiliation: State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Guangzhou 510530, China. zhu_qiang@gibh.ac.cn huang_jinbo@gibh.ac.cn.
authors.forename: Dengke
authors.initials: D
authors.lastname: Li
authors.affiliation: State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Guangzhou 510530, China. zhu_qiang@gibh.ac.cn huang_jinbo@gibh.ac.cn.
authors.forename: Tingting
authors.initials: T
authors.lastname: Mao
authors.affiliation: State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Guangzhou 510530, China. zhu_qiang@gibh.ac.cn huang_jinbo@gibh.ac.cn.
authors.forename: Jinbo
authors.initials: J
authors.lastname: Huang
authors.affiliation: State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Guangzhou 510530, China. zhu_qiang@gibh.ac.cn huang_jinbo@gibh.ac.cn.
authors.forename: Qiang
authors.identifier: http://orcid.org/0000-0002-1243-2391
authors.initials: Q
authors.lastname: Zhu