title: Updates in understanding the role of cyclophilin A in leukocyte chemotaxis.
abstract: Cyclophilin A (CypA), a well-recognized receptor for anti-inflammatory drug cyclosporine A (CsA) is a ubiquitous and multifunctional protein. Beside the diverse intracellular functions, CypA is secreted against inflammatory stimuli, where it activates and attracts leukocytes via CD147 to the stimulus site. Interestingly, it synergizes with other factors to induce leukocyte migration in different animals. However, the silencing and inhibition of CypA or CD147 inhibits leukocytes chemotaxis and inflammation. This review focuses on the advances made in understanding the mechanism of CypA-dependent leukocytes chemotaxis and hence, recognition of this factor as a possible therapeutic target in inflammatory diseases.
authors.affiliation: College of Fisheries, Huazhong Agricultural University Wuhan, Hubei, China.
authors.forename: Farman Ullah
authors.initials: FU
authors.lastname: Dawar
authors.affiliation: College of Fisheries, Huazhong Agricultural University Wuhan, Hubei, China.
authors.forename: Junjie
authors.initials: J
authors.lastname: Wu
authors.affiliation: College of Fisheries, Huazhong Agricultural University Wuhan, Hubei, China.|College of Animal Sciences and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, Guangdong, China.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Department of Zoology, Hazara University Mansehra, Khyber Pakhtunkhwa, Pakistan; and.|Department of Applied Biology, College of Sciences, University of Sharjah, Sharjah, United Arab Emirates.
authors.forename: Muhammad Nasir Khan
authors.initials: MN
authors.lastname: Khattak
authors.affiliation: College of Fisheries, Huazhong Agricultural University Wuhan, Hubei, China; jiemei@mail.hzau.edu.cn.
authors.forename: Jie
authors.initials: J
authors.lastname: Mei
authors.affiliation: College of Fisheries, Huazhong Agricultural University Wuhan, Hubei, China; linli@mail.hzau.edu.cn.|College of Animal Sciences and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, Guangdong, China.
authors.forename: Li
authors.initials: L
authors.lastname: Lin
mesh_terms: D000818:Animals; D002634:Chemotaxis, Leukocyte; D021984:Cyclophilin A / Q000378:metabolism*; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology; D008954:Models, Biological
chemical_list: D021984:Cyclophilin A
keywords: cyclosporine A; inflammation; migration