title: Prognostic Nutritional Index score is useful to predict post-operative mortality and morbidity in gastric cancer.
abstract: Background - The Prognostic Nutritional Index (PNI) score is based on the level of lymphocytes and albuminemia. The aim of this study was to validate the pre-operative PNI score for predicting post-operative mortality and morbidity of patients operated on for gastric cancer. Methods - This retrospective study collected data from patients operated on for a gastric cancer at the surgical unit B of Charles Nicolle's hospital in Tunis between January 1st, 2008 and December 31, 2012. The main outcome measure was post-operative death within 30 days. The secondary outcome was post-operative morbidity (within 30 days). We have performed a descriptive analysis, a univariate and multivariate analysis with logistic regression and a ROC curve analysis. Results - 14 women and 26 men were enrolled, with a sex ratio of 1,85. The mean age was 63 ± 15. Post-operative mortality and morbidity rate were respectively 18% and 28%. The ROC curve allowed us to validate the PNI for predicting post-operative mortality in gastric cancer with a threshold level of 38 with sensitivity 100% and specificity 64%. PNI was also validated for post-operative morbidity with a threshold level of 38 with sensitivity 82% and specificity 66%. Conclusion - PNI was validated for predicting post-operative mortality and post-operative morbidity in gastric cancer.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Khalfallah
authors.forename: Hichem
authors.initials: H
authors.lastname: Jerraya
authors.forename: Akram
authors.initials: A
authors.lastname: Sbai
authors.forename: Wejih
authors.initials: W
authors.lastname: Dougaz
authors.forename: Amel
authors.initials: A
authors.lastname: Changuel
authors.forename: Ramzi
authors.initials: R
authors.lastname: Nouira
authors.forename: Ibtissem
authors.initials: I
authors.lastname: Bouasker
authors.forename: Chadli
authors.initials: C
authors.lastname: Dziri
mesh_terms: D000704:Analysis of Variance; D005260:Female; D005743:Gastrectomy; D006801:Humans; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D015596:Nutrition Assessment; D009752:Nutritional Status; D017063:Outcome Assessment, Health Care; D011183:Postoperative Complications / Q000401:mortality*; D011379:Prognosis; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D012709:Serum Albumin; D013274:Stomach Neoplasms / Q000097:blood / Q000401:mortality* / Q000601:surgery
chemical_list: D012709:Serum Albumin