title: Global and regional annual brain volume loss rates in physiological aging.
abstract: The objective is to estimate average global and regional percentage brain volume loss per year (BVL/year) of the physiologically ageing brain. Two independent, cross-sectional single scanner cohorts of healthy subjects were included. The first cohort (n = 248) was acquired at the Medical Prevention Center (MPCH) in Hamburg, Germany. The second cohort (n = 316) was taken from the Open Access Series of Imaging Studies (OASIS). Brain parenchyma (BP), grey matter (GM), white matter (WM), corpus callosum (CC), and thalamus volumes were calculated. A non-parametric technique was applied to fit the resulting age-volume data. For each age, the BVL/year was derived from the age-volume curves. The resulting BVL/year curves were compared between the two cohorts. For the MPCH cohort, the BVL/year curve of the BP was an increasing function starting from 0.20% at the age of 35 years increasing to 0.52% at 70 years (corresponding values for GM ranged from 0.32 to 0.55%, WM from 0.02 to 0.47%, CC from 0.07 to 0.48%, and thalamus from 0.25 to 0.54%). Mean absolute difference between BVL/year trajectories across the age range of 35-70 years was 0.02% for BP, 0.04% for GM, 0.04% for WM, 0.11% for CC, and 0.02% for the thalamus. Physiological BVL/year rates were remarkably consistent between the two cohorts and independent from the scanner applied. Average BVL/year was clearly age and compartment dependent. These results need to be taken into account when defining cut-off values for pathological annual brain volume loss in disease models, such as multiple sclerosis.
authors.affiliation: Neuroimmunology and Multiple Sclerosis Research, Department of Neurology, University Hospital Zurich and University of Zurich, Frauenklinikstrasse 26, 8091, Zurich, Switzerland. sven.schippling@usz.ch.
authors.forename: Sven
authors.initials: S
authors.lastname: Schippling
authors.affiliation: jung diagnostics GmbH, Martinistrasse 52, 20251, Hamburg, Germany.
authors.forename: Ann-Christin
authors.initials: AC
authors.lastname: Ostwaldt
authors.affiliation: jung diagnostics GmbH, Martinistrasse 52, 20251, Hamburg, Germany.
authors.forename: Per
authors.initials: P
authors.lastname: Suppa
authors.affiliation: jung diagnostics GmbH, Martinistrasse 52, 20251, Hamburg, Germany.
authors.forename: Lothar
authors.initials: L
authors.lastname: Spies
authors.affiliation: Neuroimmunology and Multiple Sclerosis Research, Department of Neurology, University Hospital Zurich and University of Zurich, Frauenklinikstrasse 26, 8091, Zurich, Switzerland.
authors.forename: Praveena
authors.initials: P
authors.lastname: Manogaran
authors.affiliation: Medical Prevention Center Hamburg (MPCH), Falkenried 88, 20251, Hamburg, Germany.
authors.forename: Carola
authors.initials: C
authors.lastname: Gocke
authors.affiliation: Swiss Epilepsy Centre, Bleulerstrasse 60, 8008, Zurich, Switzerland.
authors.forename: Hans-Jürgen
authors.initials: HJ
authors.lastname: Huppertz
authors.affiliation: Neuroimmunology and Multiple Sclerosis Research, Department of Neurology, University Hospital Zurich and University of Zurich, Frauenklinikstrasse 26, 8091, Zurich, Switzerland.|jung diagnostics GmbH, Martinistrasse 52, 20251, Hamburg, Germany.
authors.forename: Roland
authors.identifier: http://orcid.org/0000-0002-9911-5478
authors.initials: R
authors.lastname: Opfer
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology*; D001284:Atrophy; D001921:Brain / Q000000981:diagnostic imaging* / Q000473:pathology; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D005858:Germany; D066128:Gray Matter / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D066127:White Matter / Q000000981:diagnostic imaging / Q000473:pathology; D055815:Young Adult
keywords: Brain atrophy; Brain volumetry; Grey matter; Magnetic resonance imaging; Multiple sclerosis; Physiological aging; Thalamus; White matter