title: Nanopolymersomes with an Ultrahigh Iodine Content for High-Performance X-Ray Computed Tomography Imaging In Vivo.
abstract: Biocompatible and biodegradable nanopolymersomes with an unprecedented iodine content, low viscosity, and iso-osmolality achieve significantly enhanced CT imaging of blood pool and the reticuloendothelial system. Moreover, in subcutaneous and orthotopic tumor models in mice, they show enhanced in vivo imaging when compared to iohexol, a clinically used small-molecule contrast agent.
authors.affiliation: Biomedical Polymers Laboratory, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, P.R. China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zou
authors.affiliation: Biomedical Polymers Laboratory, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, P.R. China.|Department of Biomaterials Science and Technology, MIRA Institute for Biological Technology and Technical Medicine, University of Twente, PO Box 217, 7500AE, Enschede, The Netherlands.
authors.forename: Yaohua
authors.initials: Y
authors.lastname: Wei
authors.affiliation: Center for Molecular Imaging and Nuclear Medicine, School for Radiological and Interdisciplinary Sciences, Soochow University, Suzhou, 215123, P.R. China.
authors.forename: Guanglin
authors.initials: G
authors.lastname: Wang
authors.affiliation: Biomedical Polymers Laboratory, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, P.R. China.
authors.forename: Fenghua
authors.initials: F
authors.lastname: Meng
authors.affiliation: Center for Molecular Imaging and Nuclear Medicine, School for Radiological and Interdisciplinary Sciences, Soochow University, Suzhou, 215123, P.R. China.
authors.forename: Mingyuan
authors.initials: M
authors.lastname: Gao
authors.affiliation: Department of Biomaterials Science and Technology, MIRA Institute for Biological Technology and Technical Medicine, University of Twente, PO Box 217, 7500AE, Enschede, The Netherlands.
authors.forename: Gert
authors.initials: G
authors.lastname: Storm
authors.affiliation: Biomedical Polymers Laboratory, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, P.R. China.
authors.forename: Zhiyuan
authors.initials: Z
authors.lastname: Zhong
mesh_terms: D000818:Animals; D003287:Contrast Media; D007454:Iodides; D007455:Iodine / Q000737:chemistry*; D007472:Iohexol; D051379:Mice; D049329:Nanostructures; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media; D007454:Iodides; D007472:Iohexol; D007455:Iodine
keywords: computed tomography; contrast agents; polymersomes; targeted imaging