title: Objectively measured sedentary behavior and brain volumetric measurements in multiple sclerosis.
abstract: OBJECTIVE
  This study examined the association between sedentary behavior patterns and whole brain gray matter (GM), white matter (WM) and subcortical GM structures in persons with multiple sclerosis (MS).
  
  
  METHODS
  36 persons with MS wore an accelerometer and underwent a brain MRI. Whole brain GM and WM and deep GM structures were calculated from 3D T1-weighted structural brain images.
  
  
  RESULTS
  There were statistically significant (p < 0.01) and moderate or large associations between number of sedentary bouts/day and brain volume measures. The primary result was a consistent negative association between number of sedentary bouts/day and whole brain GM and WM, and deep GM structures.
  
  
  CONCLUSIONS
  We provide novel evidence for decreased brain volume as a correlate of a sedentary behavior pattern in persons with MS.
authors.affiliation: Department of Kinesiology & Community Health, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
authors.forename: Rachel E
authors.initials: RE
authors.lastname: Klaren
authors.affiliation: Department of Kinesiology & Community Health, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Hubbard
authors.affiliation: Jump Trading Stimulation & Education Center, Peoria, IL 61603, USA.
authors.forename: Nathan C
authors.initials: NC
authors.lastname: Wetter
authors.affiliation: Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
authors.forename: Bradley P
authors.initials: BP
authors.lastname: Sutton
authors.affiliation: Department of Physical Therapy, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
authors.forename: Robert W
authors.initials: RW
authors.lastname: Motl
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D009103:Multiple Sclerosis / Q000000981:diagnostic imaging* / Q000473:pathology; D009929:Organ Size; D057185:Sedentary Behavior
keywords: brain volumetrics; multiple sclerosis; sedentary behavior patterns