title: Catalytic Asymmetric Bromocyclization of Polyenes.
abstract: The first catalytic asymmetric bromonium ion-induced polyene cyclization has been achieved by using a chiral BINOL-derived thiophosphoramide catalyst and 1,3-dibromo-5,5-dimethylhydantoin as an electrophilic bromine source. Bromocyclization products are obtained in high yields, with good enantiomeric ratios and high diastereoselectivity, and are abundantly found as scaffolds in natural products.
authors.affiliation: Molecular Catalyst Research Center, Chubu University , 1200 Matsumoto-cho, Kasugai, Aichi 487-8501, Japan.
authors.forename: Ramesh C
authors.initials: RC
authors.lastname: Samanta
authors.affiliation: Molecular Catalyst Research Center, Chubu University , 1200 Matsumoto-cho, Kasugai, Aichi 487-8501, Japan.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Yamamoto