title: Elevated serum complement C3 levels are associated with prehypertension in an adult population.
abstract: Prehypertension is a public health epidemic associated with various adverse outcomes, but can be reversed by timely intervention. However, little attention has been paid to prehypertension. Complement C3 is a central hub of complement-related immune system. We examined the association between C3 and prehypertension in an adult population for the first time, aiming to investigate whether pro-inflammatory immune response is involved in the prehypertensive state. About 7820 Tianjin residents without hypertension were categorized into sex-specific quintiles based on their serum concentration of complement C3. Adjusted logistic regression models were used separately by gender to assess the association between C3 quintiles and the prevalence of prehypertension. After multiple adjustment, the odds ratios (95% confidence interval) for prehypertension across increasing quintiles of C3 were 1.00 (reference), 1.02 (0.84, 1.25), 1.15 (0.94, 1.42), 1.25 (1.01, 1.54), and 1.71 (1.35, 2.17) (p for trend < 0.0001) among men and were 1.00 (reference), 1.17 (0.92, 1.49), 1.13 (0.88, 1.44), 1.15 (0.89, 1.48), and 1.40 (1.07, 1.84) (p for trend = 0.03) among women. The findings suggested that elevated serum C3 levels are associated with prehypertension. Reducing inflammation may be a potential therapeutic strategy for prehypertension and hypertension that is worthy of further studies and discussion.
authors.affiliation: a Nutritional Epidemiology Institute and School of Public Health , Tianjin Medical University , Tianjin , China.
authors.forename: Xue
authors.initials: X
authors.lastname: Bao
authors.affiliation: a Nutritional Epidemiology Institute and School of Public Health , Tianjin Medical University , Tianjin , China.
authors.forename: Ge
authors.initials: G
authors.lastname: Meng
authors.affiliation: b Health Management Center , Tianjin Medical University General Hospital , Tianjin , China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: b Health Management Center , Tianjin Medical University General Hospital , Tianjin , China.
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.affiliation: a Nutritional Epidemiology Institute and School of Public Health , Tianjin Medical University , Tianjin , China.
authors.forename: Hongmei
authors.initials: H
authors.lastname: Wu
authors.affiliation: a Nutritional Epidemiology Institute and School of Public Health , Tianjin Medical University , Tianjin , China.
authors.forename: Huanmin
authors.initials: H
authors.lastname: Du
authors.affiliation: b Health Management Center , Tianjin Medical University General Hospital , Tianjin , China.
authors.forename: Hongbin
authors.initials: H
authors.lastname: Shi
authors.affiliation: a Nutritional Epidemiology Institute and School of Public Health , Tianjin Medical University , Tianjin , China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Xia
authors.affiliation: a Nutritional Epidemiology Institute and School of Public Health , Tianjin Medical University , Tianjin , China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Guo
authors.affiliation: a Nutritional Epidemiology Institute and School of Public Health , Tianjin Medical University , Tianjin , China.
authors.forename: Xing
authors.initials: X
authors.lastname: Liu
authors.affiliation: c Department of Rehabilitation and Sports Medicine , Tianjin Medical University , Tianjin , China.
authors.forename: Peipei
authors.initials: P
authors.lastname: Han
authors.affiliation: c Department of Rehabilitation and Sports Medicine , Tianjin Medical University , Tianjin , China.
authors.forename: Renwei
authors.initials: R
authors.lastname: Dong
authors.affiliation: c Department of Rehabilitation and Sports Medicine , Tianjin Medical University , Tianjin , China.
authors.forename: Xiuyang
authors.initials: X
authors.lastname: Wang
authors.affiliation: a Nutritional Epidemiology Institute and School of Public Health , Tianjin Medical University , Tianjin , China.
authors.forename: Chunlei
authors.initials: C
authors.lastname: Li
authors.affiliation: a Nutritional Epidemiology Institute and School of Public Health , Tianjin Medical University , Tianjin , China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Su
authors.affiliation: a Nutritional Epidemiology Institute and School of Public Health , Tianjin Medical University , Tianjin , China.
authors.forename: Yeqing
authors.initials: Y
authors.lastname: Gu
authors.affiliation: a Nutritional Epidemiology Institute and School of Public Health , Tianjin Medical University , Tianjin , China.
authors.forename: Liyun
authors.initials: L
authors.lastname: Fang
authors.affiliation: a Nutritional Epidemiology Institute and School of Public Health , Tianjin Medical University , Tianjin , China.
authors.forename: Fei
authors.initials: F
authors.lastname: Yu
authors.affiliation: a Nutritional Epidemiology Institute and School of Public Health , Tianjin Medical University , Tianjin , China.
authors.forename: Huijun
authors.initials: H
authors.lastname: Yang
authors.affiliation: c Department of Rehabilitation and Sports Medicine , Tianjin Medical University , Tianjin , China.
authors.forename: Li
authors.initials: L
authors.lastname: Kang
authors.affiliation: c Department of Rehabilitation and Sports Medicine , Tianjin Medical University , Tianjin , China.
authors.forename: Yixuan
authors.initials: Y
authors.lastname: Ma
authors.affiliation: a Nutritional Epidemiology Institute and School of Public Health , Tianjin Medical University , Tianjin , China.
authors.forename: Bin
authors.initials: B
authors.lastname: Yu
authors.affiliation: a Nutritional Epidemiology Institute and School of Public Health , Tianjin Medical University , Tianjin , China.
authors.forename: Xinyu
authors.initials: X
authors.lastname: Ma
authors.affiliation: b Health Management Center , Tianjin Medical University General Hospital , Tianjin , China.
authors.forename: Shaomei
authors.initials: S
authors.lastname: Sun
authors.affiliation: b Health Management Center , Tianjin Medical University General Hospital , Tianjin , China.
authors.forename: Xing
authors.initials: X
authors.lastname: Wang
authors.affiliation: b Health Management Center , Tianjin Medical University General Hospital , Tianjin , China.
authors.forename: Ming
authors.initials: M
authors.lastname: Zhou
authors.affiliation: b Health Management Center , Tianjin Medical University General Hospital , Tianjin , China.
authors.forename: Qiyu
authors.initials: Q
authors.lastname: Jia
authors.affiliation: c Department of Rehabilitation and Sports Medicine , Tianjin Medical University , Tianjin , China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Guo
authors.affiliation: b Health Management Center , Tianjin Medical University General Hospital , Tianjin , China.
authors.forename: Kun
authors.initials: K
authors.lastname: Song
authors.affiliation: b Health Management Center , Tianjin Medical University General Hospital , Tianjin , China.
authors.forename: GuoLin
authors.initials: G
authors.lastname: Wang
authors.affiliation: a Nutritional Epidemiology Institute and School of Public Health , Tianjin Medical University , Tianjin , China.
authors.forename: Guowei
authors.initials: G
authors.lastname: Huang
authors.affiliation: a Nutritional Epidemiology Institute and School of Public Health , Tianjin Medical University , Tianjin , China.|b Health Management Center , Tianjin Medical University General Hospital , Tianjin , China.|d Collaborative Innovation Center of Non-communicable Disease , Tianjin Medical University , Tianjin , China.
authors.forename: Kaijun
authors.initials: K
authors.lastname: Niu
mesh_terms: D000328:Adult; D002681:China / Q000453:epidemiology; D003176:Complement C3 / Q000378:metabolism*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D058246:Prehypertension / Q000097:blood* / Q000453:epidemiology*; D015995:Prevalence; D012307:Risk Factors
chemical_list: D003176:Complement C3
keywords: Inflammation; complement C3; cross-sectional; population studies; prehypertension