title: Administration of Zinc plus Cyclo-(His-Pro) Increases Hippocampal Neurogenesis in Rats during the Early Phase of Streptozotocin-Induced Diabetes.
abstract: The effects of zinc supplementation on hippocampal neurogenesis in diabetes mellitus have not been studied. Herein, we investigated the effects of zinc plus cyclo-(His-Pro) (ZC) on neurogenesis occurring in the subgranular zone of dentate gyrus after streptozotocin (STZ)-induced diabetes. ZC (27 mg/kg) was administered by gavage once daily for one or six weeks from the third day after the STZ injection, and histological evaluation was performed at 10 (early phase) or 45 (late phase) days after STZ injection. We found that the proliferation of progenitor cells in STZ-induced diabetic rats showed an increase in the early phase. Additionally, ZC treatment remarkably increased the number of neural progenitor cells (NPCs) and immature neurons in the early phase of STZ-induced diabetic rats. Furthermore, ZC treatment showed increased survival rate of newly generated cells but no difference in the level of neurogenesis in the late phase of STZ-induced diabetic rats. The present study demonstrates that zinc supplementation by ZC increases both NPCs proliferation and neuroblast production at the early phase of diabetes. Thus, this study suggests that zinc supplemented with a histidine/proline complex may have beneficial effects on neurogenesis in patients experiencing the early phase of Type 1 diabetes.
authors.affiliation: Department of Physiology, College of Medicine, Hallym University, Chuncheon 24252, Korea. bychoi@hallym.ac.kr.
authors.forename: Bo Young
authors.initials: BY
authors.lastname: Choi
authors.affiliation: Department of Physiology, College of Medicine, Hallym University, Chuncheon 24252, Korea. inyeol@hallym.ac.kr.
authors.forename: In Yeol
authors.initials: IY
authors.lastname: Kim
authors.affiliation: Department of Physiology, College of Medicine, Hallym University, Chuncheon 24252, Korea. fate0710@hallym.ac.kr.
authors.forename: Jin Hee
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Department of Physiology, College of Medicine, Hallym University, Chuncheon 24252, Korea. supsock1126@naver.com.
authors.forename: Bo Eun
authors.initials: BE
authors.lastname: Lee
authors.affiliation: Department of Physiology, College of Medicine, Hallym University, Chuncheon 24252, Korea. sshlee@hallym.ac.kr.
authors.forename: Song Hee
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Department of Physiology, College of Medicine, Hallym University, Chuncheon 24252, Korea. rnlduadkfk136@hallym.ac.kr.
authors.forename: A Ra
authors.initials: AR
authors.lastname: Kho
authors.affiliation: Department of Nursing, Inha University, Incheon 22212, Korea. sohnmin@inha.ac.kr.
authors.forename: Min
authors.initials: M
authors.lastname: Sohn
authors.affiliation: Department of Physiology, College of Medicine, Hallym University, Chuncheon 24252, Korea. swsuh@hallym.ac.kr.
authors.forename: Sang Won
authors.initials: SW
authors.lastname: Suh
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D004151:Dipeptides / Q000627:therapeutic use*; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects* / Q000503:physiopathology*; D008297:Male; D058953:Neural Stem Cells / Q000187:drug effects / Q000473:pathology; D055495:Neurogenesis / Q000187:drug effects*; D017207:Rats, Sprague-Dawley; D013311:Streptozocin; D015032:Zinc / Q000627:therapeutic use*
chemical_list: D004151:Dipeptides; C035699:histidylproline; D013311:Streptozocin; D015032:Zinc
keywords: diabetes; hippocampus; neurogenesis; streptozotocin; zinc; zinc plus cyclo-(His-Pro)