title: Characteristics of children with food protein-induced enterocolitis and allergic proctocolitis.
abstract: The aim of this study was to determine and compare the clinical and laboratory features of food protein-induced enterocolitis syndrome (FPIES) and food protein-induced allergic proctocolitis (FPIAP), and to provide information about the short-term prognoses.
  
  
  
  Children diagnosed with FPIES or FPIAP between 2010 and 2015 were enrolled in this study.
  
  
  
  Overall, 64 infants (37 FPIAP, 27 FPIES) were evaluated, with the average age at the onset of symptoms being significantly lower in the patients with FPIAP than in the patients with FPIES (2 months [1-3 months] versus 4 months [1.5-6 months]; p = 0.043). Fifteen of the patients with FPIAP (40.5%) and six of the patients with FPIES (22.2%) were exclusively breast-fed at the time of the onset of symptoms. Cow's milk was the most frequent trigger (100% FPIAP, 74% FPIES); solid foods caused FPIES more frequently. Forty-eight of the 64 patients were followed up until at least 2 years of age, with the resolution rates being 91.3% for FPIAP and 60% for FPIES. The solid food-induced cases of FPIES (27.3%) had a significantly lower rate of resolution than the liquid food-induced FPIES (83.3%) (p = 0.003).
  
  
  
  Cow's milk is the most common trigger of both FPIAP and FPIES. The symptom onset age seemed to be earlier in FPIAP. The resolution age was similar, however, the recovery in FPIES may be later if the trigger food is solid. To our knowledge, this was the first clinical study to compare the clinical and laboratory characteristics of patients with FPIAP and FPIES.
authors.forename: Ebru
authors.initials: E
authors.lastname: Arik Yilmaz
authors.forename: Ozge
authors.initials: O
authors.lastname: Soyer
authors.forename: Ozlem
authors.initials: O
authors.lastname: Cavkaytar
authors.forename: Betul
authors.initials: B
authors.lastname: Karaatmaca
authors.forename: Betul
authors.initials: B
authors.lastname: Buyuktiryaki
authors.forename: Umit M
authors.initials: UM
authors.lastname: Sahiner
authors.forename: Bulent E
authors.initials: BE
authors.lastname: Sekerel
authors.forename: Cansin
authors.initials: C
authors.lastname: Sackesen
mesh_terms: D017668:Age of Onset; D000818:Animals; D002417:Cattle; D002648:Child; D002675:Child, Preschool; D004044:Dietary Proteins / Q000008:administration & dosage / Q000009:adverse effects*; D004760:Enterocolitis / Q000175:diagnosis* / Q000209:etiology*; D004804:Eosinophils; D005260:Female; D005500:Follow-Up Studies; D005512:Food Hypersensitivity / Q000150:complications* / Q000175:diagnosis* / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology; D007223:Infant; D007958:Leukocyte Count; D008297:Male; D010641:Phenotype; D011350:Proctocolitis / Q000175:diagnosis* / Q000209:etiology*; D011379:Prognosis
chemical_list: D004044:Dietary Proteins; D007073:Immunoglobulin E