title: Predictive performance of the quick Sequential Organ Failure Assessment score as a screening tool for sepsis, mortality, and intensive care unit admission in patients with febrile neutropenia.
abstract: In Sepsis-3, the quick Sequential Organ Failure Assessment (qSOFA) score was developed as criteria to use for recognizing patients who may have poor outcomes. This study was performed to evaluate the predictive performance of the qSOFA score as a screening tool for sepsis, mortality, and intensive care unit (ICU) admission in patients with febrile neutropenia (FN). We also tried to compare its performance with that of the systemic inflammatory response syndrome (SIRS) criteria and Multinational Association of Supportive Care in Cancer (MASCC) score for FN.
  
  
  
  We used a prospectively collected adult FN data registry. The qSOFA and SIRS scores were calculated retrospectively using the preexisting data. The primary outcome was the development of sepsis. The secondary outcomes were ICU admission and 28-day mortality.
  
  
  
  Of the 615 patients, 100 developed sepsis, 20 died, and 38 were admitted to ICUs. In multivariate analysis, qSOFA was an independent factor predicting sepsis and ICU admission. However, compared to the MASCC score, the area under the receiver operating curve of qSOFA was lower. qSOFA showed a low sensitivity (0.14, 0.2, and 0.23) but high specificity (0.98, 0.97, and 0.97) in predicting sepsis, 28-day mortality, and ICU admission.
  
  
  
  Performance of the qSOFA score was inferior to that of the MASCC score. The preexisting risk stratification tool is more useful for predicting outcomes in patients with FN.
authors.affiliation: College of Medicine, Cancer Emergency Room, Department of Emergency Medicine, Asan Medical Center, University of Ulsan, 388-1, Pungnap-dong, Songpa-gu, Seoul, 138-736, South Korea.
authors.forename: Minsoo
authors.initials: M
authors.lastname: Kim
authors.affiliation: College of Medicine, Cancer Emergency Room, Department of Emergency Medicine, Asan Medical Center, University of Ulsan, 388-1, Pungnap-dong, Songpa-gu, Seoul, 138-736, South Korea. ans1023@gmail.com.
authors.forename: Shin
authors.initials: S
authors.lastname: Ahn
authors.affiliation: College of Medicine, Cancer Emergency Room, Department of Emergency Medicine, Asan Medical Center, University of Ulsan, 388-1, Pungnap-dong, Songpa-gu, Seoul, 138-736, South Korea.
authors.forename: Won Young
authors.initials: WY
authors.lastname: Kim
authors.affiliation: College of Medicine, Cancer Emergency Room, Department of Emergency Medicine, Asan Medical Center, University of Ulsan, 388-1, Pungnap-dong, Songpa-gu, Seoul, 138-736, South Korea.
authors.forename: Chang Hwan
authors.initials: CH
authors.lastname: Sohn
authors.affiliation: College of Medicine, Cancer Emergency Room, Department of Emergency Medicine, Asan Medical Center, University of Ulsan, 388-1, Pungnap-dong, Songpa-gu, Seoul, 138-736, South Korea.
authors.forename: Dong Woo
authors.initials: DW
authors.lastname: Seo
authors.affiliation: College of Medicine, Cancer Emergency Room, Department of Emergency Medicine, Asan Medical Center, University of Ulsan, 388-1, Pungnap-dong, Songpa-gu, Seoul, 138-736, South Korea.
authors.forename: Yoon-Seon
authors.initials: YS
authors.lastname: Lee
authors.affiliation: College of Medicine, Cancer Emergency Room, Department of Emergency Medicine, Asan Medical Center, University of Ulsan, 388-1, Pungnap-dong, Songpa-gu, Seoul, 138-736, South Korea.
authors.forename: Kyung Soo
authors.initials: KS
authors.lastname: Lim
mesh_terms: D064147:Febrile Neutropenia / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008403:Mass Screening / Q000379:methods*; D008875:Middle Aged; D063305:Organ Dysfunction Scores; D011379:Prognosis; D011446:Prospective Studies; D012189:Retrospective Studies; D018805:Sepsis / Q000209:etiology*
keywords: Febrile neutropenia; Sepsis; qSOFA score