title: Coregulator-mediated control of skeletal muscle plasticity - A mini-review.
abstract: Skeletal muscle plasticity is a complex process entailing massive transcriptional programs. These changes are mediated by the action of nuclear receptors and other transcription factors. In addition, coregulator proteins have emerged as important players in this process by linking transcription factors to the RNA polymerase II complex and inducing changes in the chromatic structure. An accumulating body of work highlights the pleiotropic functions of coregulator proteins in the control of tissue-specific and whole body metabolism. In skeletal muscle, several coregulators have been identified as potent modulators of metabolic and myofibrillar plasticity. In this mini-review, we will discuss the control, function and physiological significance of these coregulators in skeletal muscle biology.
authors.affiliation: Biozentrum, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland.
authors.forename: Svenia
authors.initials: S
authors.lastname: Schnyder
authors.affiliation: Biozentrum, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland.
authors.forename: Barbara
authors.initials: B
authors.lastname: Kupr
authors.affiliation: Biozentrum, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland. Electronic address: christoph.handschin@unibas.ch.
authors.forename: Christoph
authors.initials: C
authors.lastname: Handschin
mesh_terms: D000818:Animals; D051548:Histone Acetyltransferases / Q000378:metabolism; D006655:Histone Deacetylases / Q000378:metabolism; D006801:Humans; D018482:Muscle, Skeletal / Q000502:physiology*; D056971:Nuclear Receptor Co-Repressor 1 / Q000502:physiology; D056918:Nuclear Receptor Coactivators / Q000502:physiology*; D011484:Protein-Arginine N-Methyltransferases / Q000378:metabolism; D016160:Retinoblastoma Protein / Q000502:physiology
chemical_list: D056971:Nuclear Receptor Co-Repressor 1; D056918:Nuclear Receptor Coactivators; D016160:Retinoblastoma Protein; D011484:Protein-Arginine N-Methyltransferases; D051548:Histone Acetyltransferases; D006655:Histone Deacetylases
keywords: Coregulators; Metabolism; PGC-1; Skeletal muscle