title: Research Advances in Chemokine-like Factor Super Family Member 8.
abstract: Chemokine-like factor super family member (CMTM) is a novel generic family firstly reported by Peking University Center for Human Disease Genomics. CMTM8 is one member of this family and has exhibited tumor-inhibiting activities. It can encode proteins approaching to the transmembrane 4 superfamily. CMTM8 is down-regulated in most carcinoma cell lines and tissues. Over-expression of CMTM8 may inhibit the proliferation,migration,and invasion of carcinoma cells. However,the exact mechanism of its anti-tumor activity remains unclear. CMTM8 may be involved in various signaling pathways governing the occurrence and development of tumors. CMTM8 may be a new target in the gene therapies for tumors,while further studies on CMTM8 and its anti-tumor mechanisms are warranted.
authors.affiliation: Department of Urology,Peking University People's Hospital,Beijing 100044,China.
authors.forename: Deng-Hui
authors.initials: DH
authors.lastname: Gao
authors.affiliation: Department of Urology,Peking University People's Hospital,Beijing 100044,China.
authors.forename: Hao
authors.initials: H
authors.lastname: Hu
authors.affiliation: Department of Urology,Peking University People's Hospital,Beijing 100044,China.
authors.forename: Zhi-Wei
authors.initials: ZW
authors.lastname: Fang
authors.affiliation: Department of Urology,Peking University People's Hospital,Beijing 100044,China.
authors.forename: Fei
authors.initials: F
authors.lastname: Huo
authors.affiliation: Department of Urology,Peking University People's Hospital,Beijing 100044,China.
authors.forename: Huan-Rui
authors.initials: HR
authors.lastname: Wang
authors.affiliation: Department of Urology,Peking University People's Hospital,Beijing 100044,China.
authors.forename: Ke-Xin
authors.initials: KX
authors.lastname: Xu
authors.affiliation: Department of Urology,Peking University People's Hospital,Beijing 100044,China.
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Wang
mesh_terms: D018925:Chemokines / Q000378:metabolism*; D015536:Down-Regulation; D006801:Humans; D062792:MARVEL Domain-Containing Proteins / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: C507076:CMTM8 protein, human; D018925:Chemokines; D062792:MARVEL Domain-Containing Proteins