title: Cytotoxic Steroids from the Vietnamese Soft Coral Sinularia conferta.
abstract: Twelve steroids, including five new compounds 1-5, were isolated and structurally elucidated from a methanol extract of the Vietnamese soft coral Sinularia conferta. Their cytotoxic effects against three human cancer cell lines, lung carcinoma (A-549), cervical adenocarcinoma (HeLa), and pancreatic epithelioid carcinoma (PANC-1), were evaluated using 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide (MTT) assays. Among isolated compounds, 10 exhibited potent cytotoxic effects on all three tested cell lines with IC50values of 3.64±0.18, 19.34±0.42, and 1.78±0.69 µM, respectively.
authors.affiliation: Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST).
authors.forename: Ninh Thi
authors.initials: NT
authors.lastname: Ngoc
authors.forename: Pham Thi Mai
authors.initials: PT
authors.lastname: Huong
authors.forename: Nguyen Van
authors.initials: NV
authors.lastname: Thanh
authors.forename: Nguyen Thi Phuong
authors.initials: NT
authors.lastname: Chi
authors.forename: Nguyen Hai
authors.initials: NH
authors.lastname: Dang
authors.forename: Nguyen Xuan
authors.initials: NX
authors.lastname: Cuong
authors.forename: Nguyen Hoai
authors.initials: NH
authors.lastname: Nam
authors.forename: Do Cong
authors.initials: DC
authors.lastname: Thung
authors.forename: Phan Van
authors.initials: PV
authors.lastname: Kiem
authors.forename: Chau Van
authors.initials: CV
authors.lastname: Minh
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D008968:Molecular Conformation; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D013256:Steroids