title: Gold nanorod embedded large-pore mesoporous organosilica nanospheres for gene and photothermal cooperative therapy of triple negative breast cancer.
abstract: To date, clinicians still lack an effective strategy to treat triple negative breast cancer (TNBC). In this work, we design for the first time a gold nanorod embedded large-pore mesoporous organosilica (GNR@LPMO) nanoplatform for gene and photothermal cooperative therapy of TNBC. The synthesized GNR@LPMOs possess a uniform size (175 nm), high surface area (631 m2g-1), large pore size, excellent photothermal efficiency, and good biocompatibility. Thanks to the large-pore mesoporous organosilica layer, the GNR@LPMO nanoplatforms display much higher loading capacity of siRNA compared with traditional liposome and bare gold nanorods. Thus, functional siRNA can be efficiently delivered into TNBC cells by GNR@LPMOs, causing much higher cell apoptosis through knocking down the PLK1 proteins. By combining the effective gene delivery and photothermal abilities, the GNR@LPMO nanoplatforms are further used for gene and photothermal cooperative therapy of TNBC, which induce a 15 fold higher mice tumor inhibition rate than sole therapy modality, indicating the potential clinical use of this novel nanoplatform in treating TNBC.
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, 305 Zhongshan East Road, Nangjing 210002, Jiangsu, P.R. China. cjr.luguangming@vip.163.com kevinzhlj@163.com and Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institute of Health, Bethesda, USA.
authors.forename: Qianqian
authors.initials: Q
authors.lastname: Ni
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, 305 Zhongshan East Road, Nangjing 210002, Jiangsu, P.R. China. cjr.luguangming@vip.163.com kevinzhlj@163.com and State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093 Jiangsu, P.R. China.
authors.forename: Zhaogang
authors.initials: Z
authors.lastname: Teng
authors.affiliation: Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Centre for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, Nanjing, 210023 Jiangsu, P.R. China.
authors.forename: Meng
authors.initials: M
authors.lastname: Dang
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, 305 Zhongshan East Road, Nangjing 210002, Jiangsu, P.R. China. cjr.luguangming@vip.163.com kevinzhlj@163.com.
authors.forename: Ying
authors.initials: Y
authors.lastname: Tian
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, 305 Zhongshan East Road, Nangjing 210002, Jiangsu, P.R. China. cjr.luguangming@vip.163.com kevinzhlj@163.com.
authors.forename: Yunlei
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University, Shenzhen, 518060 Guangdong, P.R. China.
authors.forename: Peng
authors.initials: P
authors.lastname: Huang
authors.affiliation: Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Centre for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, Nanjing, 210023 Jiangsu, P.R. China.
authors.forename: Xiaodan
authors.initials: X
authors.lastname: Su
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, 305 Zhongshan East Road, Nangjing 210002, Jiangsu, P.R. China. cjr.luguangming@vip.163.com kevinzhlj@163.com and Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institute of Health, Bethesda, USA.
authors.forename: Nan
authors.initials: N
authors.lastname: Lu
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, 305 Zhongshan East Road, Nangjing 210002, Jiangsu, P.R. China. cjr.luguangming@vip.163.com kevinzhlj@163.com.
authors.forename: Zhenlu
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, 305 Zhongshan East Road, Nangjing 210002, Jiangsu, P.R. China. cjr.luguangming@vip.163.com kevinzhlj@163.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Tian
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, 305 Zhongshan East Road, Nangjing 210002, Jiangsu, P.R. China. cjr.luguangming@vip.163.com kevinzhlj@163.com.
authors.forename: Shouju
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, 305 Zhongshan East Road, Nangjing 210002, Jiangsu, P.R. China. cjr.luguangming@vip.163.com kevinzhlj@163.com.
authors.forename: Wenfei
authors.initials: W
authors.lastname: Liu
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, 305 Zhongshan East Road, Nangjing 210002, Jiangsu, P.R. China. cjr.luguangming@vip.163.com kevinzhlj@163.com.
authors.forename: Yuxia
authors.initials: Y
authors.lastname: Tang
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, 305 Zhongshan East Road, Nangjing 210002, Jiangsu, P.R. China. cjr.luguangming@vip.163.com kevinzhlj@163.com and State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093 Jiangsu, P.R. China.
authors.forename: Guangming
authors.initials: G
authors.lastname: Lu
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, 305 Zhongshan East Road, Nangjing 210002, Jiangsu, P.R. China. cjr.luguangming@vip.163.com kevinzhlj@163.com.
authors.forename: Longjiang
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000818:Animals; D017209:Apoptosis; D018797:Cell Cycle Proteins / Q000235:genetics; D045744:Cell Line, Tumor; D005260:Female; D055785:Gene Knockdown Techniques; D015316:Genetic Therapy; D006046:Gold; D006358:Hot Temperature; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D054118:Nanospheres; D043942:Nanotubes; D010789:Phototherapy; D017346:Protein Serine-Threonine Kinases / Q000235:genetics; D011518:Proto-Oncogene Proteins / Q000235:genetics; D064726:Triple Negative Breast Neoplasms / Q000628:therapy*; D023041:Xenograft Model Antitumor Assays; D000097869:Polo-Like Kinase 1
chemical_list: D018797:Cell Cycle Proteins; D006046:Gold; D017346:Protein Serine-Threonine Kinases; D011518:Proto-Oncogene Proteins; D000097869:Polo-Like Kinase 1