title: Rapid Screening Method for New Psychoactive Substances of Forensic Interest: Electrochemistry and Analytical Determination of Phenethylamines Derivatives (NBOMe) via Cyclic and Differential Pulse Voltammetry.
abstract: The NBOMe derivatives are phenethylamines derived from the 2C class of hallucinogens. Only a few human pharmacologic studies have been conducted on these drugs, and several cases of intoxication and deaths have been reported. Presently, NBOMe are not a part of the routine drugs-of-abuse screening procedure for many police forces, and there are no rapid immunoassay screening tests that can detect the presence of those compounds. In this Article, the voltammetric behavior of 25B NBOMe and 25I NBOMe were investigated and their electroanalytical characteristics determined for the first time. A novel, fast, and sensitive screening method for the identification of the two most common NBOMes (25B-NBOMe and 25I-NBOMe) in real samples is reported. The method uses the electrochemical oxidation of these molecules to produce an analytical signal that can be related to the NBOMe concentration with an average lower limit of quantitation of 0.01 mg/mL for both of them. The method is selective enough to identify the two compounds individually, even given the great similarity in their structure.
authors.affiliation: Criminalistic Institute, Federal District Civil Police , SPO, lote 23, bloco E, 70.610-200, Brasilia, DF, Brazil.|School of Chemistry, University of Lincoln , Brayford Pool, Lincoln LN6 7TS, U.K.
authors.forename: Ana Flávia B
authors.initials: AF
authors.lastname: Andrade
authors.affiliation: School of Chemistry, University of Lincoln , Brayford Pool, Lincoln LN6 7TS, U.K.
authors.forename: Samuel Kasahun
authors.initials: SK
authors.lastname: Mamo
authors.affiliation: School of Chemistry, University of Lincoln , Brayford Pool, Lincoln LN6 7TS, U.K.
authors.forename: Jose
authors.identifier: 0000-0003-2059-3571
authors.initials: J
authors.lastname: Gonzalez-Rodriguez
mesh_terms: D000840:Anisoles / Q000032:analysis; D004118:Dimethoxyphenylethylamine / Q000031:analogs & derivatives / Q000032:analysis; D055664:Electrochemical Techniques / Q000379:methods*; D005554:Forensic Medicine; D006863:Hydrogen-Ion Concentration; D057230:Limit of Detection; D010627:Phenethylamines / Q000032:analysis* / Q000737:chemistry; D011619:Psychotropic Drugs / Q000032:analysis* / Q000737:chemistry
chemical_list: D000840:Anisoles; D004118:Dimethoxyphenylethylamine; D010627:Phenethylamines; D011619:Psychotropic Drugs; C554181:2-(4-iodo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine; C000595926:2-(4-bromo-2,5-dimethoxyphenyl)-N-((2-methoxyphenyl)methyl)ethanamine