title: Simultaneous Combined Myositis, Inflammatory Polyneuropathy, and Overlap Myasthenic Syndrome.
abstract: Immune-mediated neuromuscular disorders include pathologies of the peripheral nervous system, neuromuscular junction, and muscles. If overlap syndromes (or the association of almost two autoimmune disorders) are recognized, the simultaneous occurrence of several autoimmune neuromuscular disorders is rare. We describe two patients presenting the simultaneous occurrence of inflammatory neuropathy, myositis, and myasthenia gravis (with positive acetylcholine receptor antibodies). For each patient, we carried out a pathological analysis (nerve and muscle) and an electrophysiological study (and follow-up). To our knowledge, this is the first description of such a triple immune-mediated neuromuscular syndrome. We compared our observations with a few other cases of simultaneous diagnosis of two inflammatory neuromuscular disorders.
authors.affiliation: Department of Neurology, Nerve-Muscle Unit, CHU Bordeaux (Groupe Hospitalier Pellegrin), place Amélie-Raba-Léon, 33000 Bordeaux, France.
authors.forename: Stéphane
authors.identifier: 0000-0003-0775-4625
authors.initials: S
authors.lastname: Mathis
authors.affiliation: Department of Neurology, Centre de Référence "Neuropathies Périphériques Rares", CHU Limoges, 2 avenue Martin Luther King, 87042 Limoges, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Magy
authors.affiliation: Department of Neurology, CHU Bretonneau, 2 boulevard Tonnellé, 37044 Tours, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Corcia
authors.affiliation: Department of Neurology, Centre de Référence "Neuropathies Périphériques Rares", CHU Limoges, 2 avenue Martin Luther King, 87042 Limoges, France.
authors.forename: Karima
authors.initials: K
authors.lastname: Ghorab
authors.affiliation: Department of Neurology, Centre de Référence "Neuropathies Périphériques Rares", CHU Limoges, 2 avenue Martin Luther King, 87042 Limoges, France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Richard
authors.affiliation: Department of Neurology, CHU Poitiers, 2 rue de la Milétrie, 86021 Poitiers, France.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Ciron
authors.affiliation: Department of Neurology, Centre de Référence "Neuropathies Périphériques Rares", CHU Limoges, 2 avenue Martin Luther King, 87042 Limoges, France.
authors.forename: Mathilde
authors.initials: M
authors.lastname: Duchesne
authors.affiliation: Department of Neurology, Centre de Référence "Neuropathies Périphériques Rares", CHU Limoges, 2 avenue Martin Luther King, 87042 Limoges, France.
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Vallat