title: Lantana camara Linn root extract-mediated gold nanoparticles and their in vitro antioxidant and cytotoxic potentials.
abstract: The Lantana camara Linn root extract derived gold nanoparticles (Au NPs) were characterized by Ultraviolet-Visible spectroscopy, X-ray diffraction, fourier transform-infrared, high resolution transmission electron microscopy, selected area electron diffraction pattern and energy dispersive X-ray analyses. In DPPH assay, the inhibitory concentration (IC50) of Au NPs and gallic acid was 24.17 and 5.39 μg/ml, whereas, for cytotoxicity assay, the IC50of Au NPs was 17.72 and 32.98 μg/ml on MBA-MB-231 and Vero cells, respectively. Thus, the Au NPs possess significant in vitro antioxidant and cytotoxic properties which could be considered as potential alternate for the development of anticancer drug in future.
authors.affiliation: a Department of Biotechnology , Padmavani Arts and Science College for Women , Salem , India.
authors.forename: Rajendiran
authors.initials: R
authors.lastname: Ramkumar
authors.affiliation: b Department of Biotechnology , School of Biosciences, Periyar University , Salem , India.
authors.forename: Govindasamy
authors.initials: G
authors.lastname: Balasubramani
authors.affiliation: b Department of Biotechnology , School of Biosciences, Periyar University , Salem , India.
authors.forename: Ramalingam Karthik
authors.initials: RK
authors.lastname: Raja
authors.affiliation: b Department of Biotechnology , School of Biosciences, Periyar University , Salem , India.
authors.forename: Manickam
authors.initials: M
authors.lastname: Raja
authors.affiliation: c Department of Physics , School of Physical Sciences, Periyar University , Salem , India.
authors.forename: Raji
authors.initials: R
authors.lastname: Govindan
authors.affiliation: c Department of Physics , School of Physical Sciences, Periyar University , Salem , India.
authors.forename: Easwaradas Kreedapathy
authors.initials: EK
authors.lastname: Girija
authors.affiliation: b Department of Biotechnology , School of Biosciences, Periyar University , Salem , India.
authors.forename: Pachiappan
authors.initials: P
authors.lastname: Perumal
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D005707:Gallic Acid / Q000737:chemistry; D006046:Gold / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D032410:Lantana / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D010936:Plant Extracts; D005707:Gallic Acid; D006046:Gold
keywords: Au NPs; DPPH; HR-TEM; Lantana camara; MDA-MB-231