title: Influence of the epiretinal membrane on ranibizumab therapy outcomes in patients with diabetic macular edema.
abstract: To investigate the influence of the epiretinal membrane (ERM) on intravitreal ranibizumab (IVR) therapy for diabetic macular edema (DME).
  This retrospective study included 56 eyes of 48 patients with DME divided into two groups: the DME with ERM (study) and only DME (control) groups. Changes in the central macular thickness (CMT) and best-corrected visual acuity (BCVA) were evaluated.
  In the study group, although the CMT was significantly reduced following the first injection (p<0.001), BCVA did not improve significantly (p=0.296). However, after the first injection, the control group exhibited both a significant decrease in CMT (p<0.001) and improvement in BCVA (p<0.001). However, the improvement in BCVA in the control group was not significantly different from the outcome of the study group.
  We observed a negative short-term influence of the ERM on IVR treatment for DME.
authors.affiliation: Ophthalmology Department, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey.
authors.forename: Nimet Yesim
authors.initials: NY
authors.lastname: Ercalik
authors.affiliation: Ophthalmology Department, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey.
authors.forename: Serhat
authors.initials: S
authors.lastname: Imamoglu
authors.affiliation: Ophthalmology Department, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey.
authors.forename: Esra Turkseven
authors.initials: ET
authors.lastname: Kumral
authors.affiliation: Ophthalmology Department, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey.
authors.forename: Nursal Melda
authors.initials: NM
authors.lastname: Yenerel
authors.affiliation: Ophthalmology Department, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey.
authors.forename: Handan
authors.initials: H
authors.lastname: Bardak
authors.affiliation: Ophthalmology Department, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey.
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Bardak
mesh_terms: D000368:Aged; D020533:Angiogenesis Inhibitors / Q000008:administration & dosage*; D016022:Case-Control Studies; D003930:Diabetic Retinopathy / Q000188:drug therapy*; D019773:Epiretinal Membrane / Q000503:physiopathology*; D005260:Female; D006801:Humans; D058449:Intravitreal Injections; D008269:Macular Edema / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D000069579:Ranibizumab / Q000008:administration & dosage*; D012189:Retrospective Studies; D014792:Visual Acuity / Q000502:physiology*
chemical_list: D020533:Angiogenesis Inhibitors; D000069579:Ranibizumab