title: Creation and characterization of normal myocardial perfusion imaging databases using the IQ·SPECT system.
abstract: Image acquisition by short-time single-photon emission-computed tomography (SPECT) has been made feasible by IQ·SPECT. The aim of this study was to generate normal databases (NDBs) of thallium-201 (201Tl) myocardial perfusion imaging for IQ·SPECT, and characterize myocardial perfusion distribution.
  
  
  
  We retrospectively enrolled 159 patients with a low likelihood of cardiac diseases from four hospitals in Japan. All patients underwent short-time201Tl myocardial perfusion IQ·SPECT with or without attenuation and scatter correction (ACSC) in either supine or prone position. The mean myocardial counts were calculated using 17-segment polar maps. Three NDBs were derived from supine and prone images as well as supine images with ACSC. Differences between the supine and prone positions were observed in the uncorrected sex-segregated NDBs in the mid-inferolateral counts (p ≤ 0.016 for males and p ≤ 0.002 for females). Differences between IQ·SPECT and conventional SPECT were also observed in the mid-anterior, inferolateral, and apical lateral counts (p ≤ 0.009 for males and p ≤ 0.003 for females). Apical low counts attributed to myocardial thinning were observed in the apical anterior and apex segments in the supine IQ·SPECT NDB with ACSC.
  
  
  
  There were significant differences between uncorrected supine and prone NDBs, between uncorrected supine NDB and supine NDB with ACSC, and between uncorrected supine NDB and conventional SPECT NDB. Understanding the pattern of normal distribution in IQ-SPECT short-time acquisitions with and without ACSC will be helpful for interpretation of imaging findings in patients with coronary artery disease (CAD) or low likelihood of CAD and the NDBs will aid in quantitative analysis.
authors.affiliation: Department of Physics, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Kahoku, Ishikawa, 920-0293, Japan. okuda@kanazawa-med.ac.jp.
authors.forename: Koichi
authors.initials: K
authors.lastname: Okuda
authors.affiliation: Department of Nuclear Medicine, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan. nakajima@med.kanazawa-u.ac.jp.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Nakajima
authors.affiliation: Department of Nuclear Medicine, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan.
authors.forename: Shinro
authors.initials: S
authors.lastname: Matsuo
authors.affiliation: Department of Diagnostic Imaging and Nuclear Medicine, Tokyo Women's Medical University Hospital, Tokyo, Japan.
authors.forename: Chisato
authors.initials: C
authors.lastname: Kondo
authors.affiliation: Department of Cardiology, Fujita Health University Hospital, Aichi, Japan.
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Sarai
authors.affiliation: Department of Cardiology, National Hospital Organization Sagamihara National Hospital, Kanagawa, Japan.
authors.forename: Yoriko
authors.initials: Y
authors.lastname: Horiguchi
authors.affiliation: Department of Radiology, Kanazawa University Hospital, Kanazawa, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Konishi
authors.affiliation: Department of Quantum Medical Technology, Kanazawa University, Kanazawa, Japan.
authors.forename: Masahisa
authors.initials: M
authors.lastname: Onoguchi
authors.affiliation: Department of Molecular Imaging, Siemens Healthcare K.K., Tokyo, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Shimizu
authors.affiliation: Department of Nuclear Medicine, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan.
authors.forename: Seigo
authors.initials: S
authors.lastname: Kinuya
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016208:Databases, Factual; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D055414:Myocardial Perfusion Imaging / Q000379:methods*; D016684:Prone Position; D012189:Retrospective Studies; D016683:Supine Position; D013794:Thallium Radioisotopes; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
chemical_list: D013794:Thallium Radioisotopes; C000615114:Thallium-201
keywords: IQ·SPECT; Multifocal collimator; Myocardial perfusion imaging; Short-time SPECT acquisition