title: Metabolomics: A potential way to know the role of vitamin D on multiple sclerosis.
abstract: The literature about the influence of vitamin D on multiple sclerosis (MS) is very controversial, possibly as a result of the way through which the research on the subject has been conducted. The studies developed so far have been focused exclusively on gene expression: the effect of a given vitamin D metabolite on target receptors. The influence of the vitamin D status (either natural or after supplementation) on MS has been studied by measurement of the 25 monohydroxylated metabolite (also known as circulating form), despite the 1,25 dihydroxylated metabolite is considered the active form. In the light of the multiple metabolic pathways in which both forms of vitamin D (D2and D3) are involved, monitoring of the metabolites is crucial to know the activity of the target enzymes as a function of both the state of the MS patient and the clinical treatment applied. The study of metabolomics aspects is here proposed to clarify the present controversy. In "omics" terms, our proposal is to take profit from up-stream information-thus is, from metabolomics to genomics-with a potential subsequent step to systems biology, if required.
authors.affiliation: Department of Analytical Chemistry, Annex Marie Curie Building, Campus of Rabanales, University of Córdoba, Córdoba, Spain; University of Córdoba Agroalimentary Excellence Campus, ceiA3, Spain; Maimónides Institute of Biomedical Research (IMIBIC), Reina Sofía University Hospital, University of Córdoba, E-14005 Córdoba, Spain.
authors.forename: Diego
authors.initials: D
authors.lastname: Luque-Córdoba
authors.affiliation: Department of Analytical Chemistry, Annex Marie Curie Building, Campus of Rabanales, University of Córdoba, Córdoba, Spain; University of Córdoba Agroalimentary Excellence Campus, ceiA3, Spain; Maimónides Institute of Biomedical Research (IMIBIC), Reina Sofía University Hospital, University of Córdoba, E-14005 Córdoba, Spain. Electronic address: qa1lucam@uco.es.
authors.forename: María D
authors.initials: MD
authors.lastname: Luque de Castro
mesh_terms: D000818:Animals; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D006801:Humans; D055442:Metabolome / Q000235:genetics; D055432:Metabolomics; D009103:Multiple Sclerosis / Q000188:drug therapy* / Q000378:metabolism; D014807:Vitamin D / Q000008:administration & dosage / Q000378:metabolism* / Q000627:therapeutic use*
chemical_list: D014807:Vitamin D
keywords: Gene expression; Metabolomics; Multiple sclerosis; Vitamin D; Vitamin D metabolites