title: Genetic polymorphisms in TERT are associated with increased risk of esophageal cancer.
abstract: Single nucleotide polymorphisms (SNPs) in TERT may be associated with susceptibility to esophageal cancer. In this study, we analyzed the association between TERT SNPs and risk of esophageal cancer in 386 esophageal cancer patients and 495 healthy subjects from the Xi'an area of China. Of the four SNPs examined, rs10069690 and rs2242652 were correlated with esophageal cancer risk. Additionally, after adjusting for age and gender, the "Trs10069690Ars2242652", "Trs10069690Grs2242652" haplotypes were associated with an increased risk of esophageal cancer, while the and "Crs10069690Grs2242652" haplotype was associated with a decreased risk of esophageal cancer. These findings suggest that TERT polymorphisms may contribute to the development of esophageal cancer.
authors.affiliation: Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi'an, Shaanxi 710069, China.
authors.forename: Yifei
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi'an, Shaanxi 710069, China.|Xi'an Tiangen Precision Medical Institute, Xi'an, Shaanxi 710075, China.
authors.forename: Mengdan
authors.initials: M
authors.lastname: Yan
authors.affiliation: Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi'an, Shaanxi 710069, China.|Xi'an Tiangen Precision Medical Institute, Xi'an, Shaanxi 710075, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi'an, Shaanxi 710069, China.|Xi'an Tiangen Precision Medical Institute, Xi'an, Shaanxi 710075, China.
authors.forename: Jingjie
authors.initials: J
authors.lastname: Li
authors.affiliation: Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi'an, Shaanxi 710069, China.|Xi'an Tiangen Precision Medical Institute, Xi'an, Shaanxi 710075, China.
authors.forename: Zhengshuai
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi'an, Shaanxi 710069, China.|Xi'an Tiangen Precision Medical Institute, Xi'an, Shaanxi 710075, China.|Institution of Basic Medical Science, Xi'an Medical University, Xi'an, Shaanxi 710021, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Chen
authors.affiliation: Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi'an, Shaanxi 710069, China.|Xi'an Tiangen Precision Medical Institute, Xi'an, Shaanxi 710075, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Li
authors.affiliation: Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi'an, Shaanxi 710069, China.
authors.forename: Fulin
authors.initials: F
authors.lastname: Chen
authors.affiliation: Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi'an, Shaanxi 710069, China.|Xi'an Tiangen Precision Medical Institute, Xi'an, Shaanxi 710075, China.
authors.forename: Tianbo
authors.initials: T
authors.lastname: Jin
authors.affiliation: Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi'an, Shaanxi 710069, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Chen
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics; D014408:Biomarkers, Tumor / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D004938:Esophageal Neoplasms / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D018570:Risk Assessment; D012307:Risk Factors; D019098:Telomerase / Q000235:genetics*
chemical_list: D014408:Biomarkers, Tumor; C509186:TERT protein, human; D019098:Telomerase
keywords: SNP; TERT; esophageal cancer; northwest Chinese population; susceptibility