title: Genomic translational research: Paving the way to individualized cardiac functional analyses and personalized cardiology.
abstract: For most of Medicine's past, the best that physicians could do to cope with disease prevention and treatment was based on the expected response of an average patient. Currently, however, a more personalized/precise approach to cardiology and medicine in general is becoming possible, as the cost of sequencing a human genome has declined substantially. As a result, we are witnessing an era of precipitous advances in biomedicine and bourgeoning understanding of the genetic basis of cardiovascular and other diseases, reminiscent of the resurgence of innovations in physico-mathematical sciences and biology-anatomy-cardiology in the Renaissance, a parallel time of radical change and reformation of medical knowledge, education and practice. Now on the horizon is an individualized, diverse patient-centered, approach to medical practice that encompasses the development of new, gene-based diagnostics and preventive medicine tactics, and offers the broadest range of personalized therapies based on pharmacogenetics. Over time, translation of genomic and high-tech approaches unquestionably will transform clinical practice in cardiology and medicine as a whole, with the adoption of new personalized medicine approaches and procedures. Clearly, future prospects far outweigh present accomplishments, which are best viewed as a promising start. It is now essential for pluridisciplinary health care providers to examine the drivers and barriers to the clinical adoption of this emerging revolutionary paradigm, in order to expedite the realization of its potential. So, we are not there yet, but we are definitely on our way.
authors.affiliation: Department of Surgery, Duke University School of Medicine, Durham, NC, 27710, USA. Electronic address: apasipou@duke.edu.
authors.forename: Ares
authors.initials: A
authors.lastname: Pasipoularides
mesh_terms: D002309:Cardiology; D023281:Genomics; D006801:Humans; D057285:Precision Medicine; D057170:Translational Research, Biomedical
keywords: CRISPR-Cas9 genetic–phenotypic screen; DNA microarrays; Genome-wide association studies (GWAS); Molecular genetic biomarkers; Molecular genomic decoding of phenotypic diversity; Next-generation genome sequencing (NGS); Omics-based tests; Personalized/precise medicine; Pharmacogenomics and pharmacogenetics