title: Beta-catenin can induce hair follicle stem cell differentiation into transit-amplifying cells through c-myc activation.
abstract: Hair follicle stem cells play important roles in maintaining homeostasis and skin tissue self-renewal. Transit-amplifying cells represent the transition of cells from hair follicle stem cells into differentiated epidermal cells. Thus far, the signaling pathway and the molecular biological mechanism that regulate the proliferation and differentiation of hair follicle stem cells remain unclear. In this paper, we studied the relationship between β-catenin and c-myc during the process of the differentiation of hair follicle stem cells into transit-amplifying cells. Based on our results, the expression of β-catenin can activate the nuclear gene c-myc and regulate the expression of transit-amplifying cell markers K15, K19, a6-integrin and β1-integrin, indicating that β-catenin is involved in the transformation process from hair follicle stem cells to transit-amplifying cells and suggesting that β-catenin plays an important biological role in the induction of this differentiation process.
authors.affiliation: Department of Ultrasound Diagnosis, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 201999, China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Shen
authors.affiliation: Department of Burns and Plastic Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 201999, China.
authors.forename: Weirong
authors.initials: W
authors.lastname: Yu
authors.affiliation: Department of Burns and Plastic Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 201999, China; Institute of Traumatic Medicine, School of Medicine, Shanghai Jiao Tong University, Shanghai 201999, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Fang
authors.affiliation: Department of Burns and Plastic Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 201999, China; Institute of Traumatic Medicine, School of Medicine, Shanghai Jiao Tong University, Shanghai 201999, China; Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
authors.forename: Min
authors.initials: M
authors.lastname: Yao
authors.affiliation: Department of Burns and Plastic Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 201999, China. Electronic address: ypg_999@163.com.
authors.forename: Penggao
authors.initials: P
authors.lastname: Yang
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000235:genetics*; D049109:Cell Proliferation / Q000235:genetics; D000078404:Epidermal Cells; D004817:Epidermis / Q000254:growth & development; D018507:Gene Expression Regulation, Developmental; D018859:Hair Follicle / Q000166:cytology* / Q000254:growth & development; D006801:Humans; D051379:Mice; D016271:Proto-Oncogene Proteins c-myc / Q000096:biosynthesis* / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism; D051176:beta Catenin / Q000096:biosynthesis* / Q000235:genetics
chemical_list: C489427:MYC protein, human; D016271:Proto-Oncogene Proteins c-myc; D051176:beta Catenin
keywords: Hair follicle stem cell; Transit-amplifying cell; c-myc; β-Catenin