title: Matrix pathobiology-central roles for proteoglycans and heparanase in health and disease.
abstract: This thematic minireview series highlights new concepts in matrix pathobiology. The reviews in this series cover the roles of the two matrix proteoglycans, decorin and biglycan, in inflammation and autophagy, the various functions of syndecans in cancer development and prognosis and the recently discovered mechanisms underlying the multiple roles of heparanase in cancer progression, inflammation, and autophagy.
authors.affiliation: Biochemistry Laboratory, Biochemistry, Biochemical Analysis & Matrix Pathobiology Research Group, Department of Chemistry, University of Patras, Greece.
authors.forename: Nikos K
authors.initials: NK
authors.lastname: Karamanos
mesh_terms: D058578:Biglycan / Q000378:metabolism*; D058575:Decorin / Q000378:metabolism*; D005109:Extracellular Matrix / Q000378:metabolism*; D005966:Glucuronidase / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology; D053667:Syndecans / Q000378:metabolism; D000099175:Heparanase
chemical_list: D058578:Biglycan; D058575:Decorin; D005966:Glucuronidase; D053667:Syndecans; D000099175:Heparanase; C546878:DCN protein, human