title: Sensitization predicts asthma development among wheezing toddlers in secondary healthcare.
abstract: Some wheezing toddlers develop asthma later in childhood. Sensitization is known to predict asthma in birth cohorts. However, its predictive value in secondary healthcare is uncertain.
  
  
  
  This study examines the predictive value of sensitization to inhalant allergens among wheezing toddlers in secondary healthcare for the development of asthma at school age (≥6 years).
  
  
  
  Preschool children (1-3 years) who presented with wheezing in secondary healthcare were screened on asthma at school age with the International Study of Asthma and Allergies in Childhood questionnaire. The positive and negative predictive value (PPV and NPV) of specific IgE to inhalant allergens (cut-off concentration 0.35 kU/L) and several non-invasive variables from a child's history (such as hospitalization, eczema, and parental atopy) were calculated. The additional predictive value of sensitization when combined with non-invasive predictors was examined in multivariate analysis and by ROC curves.
  
  
  
  Of 116 included children, 63% developed asthma at school age. Sensitization to inhalant allergens was a strong asthma predictor. The odds ratio (OR), PPV and NPV were 7.4%, 86%, and 55%, respectively. Eczema (OR 3.4) and hospital admission (OR 2.6) were significant non-invasive determinants. Adding sensitization to these non-invasive predictors in multivariate analysis resulted in a significantly better asthma prediction. The area under the ROC curve increased from 0.70 with only non-invasive predictors to 0.79 after adding sensitization.
  
  
  
  Sensitization to inhalant allergens is a strong predictor of school age asthma in secondary healthcare and has added predictive value when combined with non-invasive determinants. Pediatr Pulmonol. 2017;52:729-736. © 2017 Wiley Periodicals, Inc.
authors.affiliation: Department of Pediatrics, St. Antonius Hospital, PO Box 2500, 3430 EM Nieuwegein, The Netherlands.
authors.forename: Nienke A
authors.initials: NA
authors.lastname: Boersma
authors.affiliation: Department of Pediatrics, St. Antonius Hospital, PO Box 2500, 3430 EM Nieuwegein, The Netherlands.
authors.forename: Ruud W H
authors.initials: RWH
authors.lastname: Meijneke
authors.affiliation: Department of Medical Sciences and Education, St. Antonius Hospital, Nieuwegein, The Netherlands.
authors.forename: Johannes C
authors.initials: JC
authors.lastname: Kelder
authors.affiliation: Department of Pediatric Pulmonology, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: Cornelis K
authors.initials: CK
authors.lastname: van der Ent
authors.affiliation: Department of Pediatrics, St. Antonius Hospital, PO Box 2500, 3430 EM Nieuwegein, The Netherlands.
authors.forename: Walter A F
authors.initials: WAF
authors.lastname: Balemans
mesh_terms: D000485:Allergens / Q000276:immunology; D001249:Asthma / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000453:epidemiology*; D007073:Immunoglobulin E / Q000276:immunology; D007223:Infant; D008297:Male; D016017:Odds Ratio; D012372:ROC Curve; D012135:Respiratory Sounds; D011795:Surveys and Questionnaires
chemical_list: D000485:Allergens; D007073:Immunoglobulin E
keywords: asthma; child; secondary care; sensitization; wheezing