title: Cornerstones of Toxicology.
abstract: The 35th Annual Society of Toxicologic Pathology Symposium, held in June 2016 in San Diego, California, focused on "The Basis and Relevance of Variation in Toxicologic Responses." In order to review the basic tenants of toxicology, a "broad brush" interactive talk that gave an overview of the Cornerstones of Toxicology was presented. The presentation focused on the historical milestones and perspectives of toxicology and through many scientific graphs, data, and real-life examples covered the three basic principles of toxicology that can be summarized, as dose matters (as does timing), people differ, and things change (related to metabolism and biotransformation).
authors.affiliation: 1 Harvard University, Cambridge, Massachusetts, USA.|2 Michigan State University, East Lansing, Michigan, USA.
authors.forename: A Wallace
authors.initials: AW
authors.lastname: Hayes
authors.affiliation: 3 National Institute of Environmental Health Sciences and the National Toxicology Program, National Institutes of Health (NIH), U.S. Department of Health and Human Services (HHS), Research Triangle Park, North Carolina, USA.
authors.forename: Darlene
authors.initials: D
authors.lastname: Dixon
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D049672:History, 19th Century; D049673:History, 20th Century; D049674:History, 21st Century; D049690:History, Ancient; D006801:Humans; D010336:Pathology / Q000266:history / Q000379:methods*; D011041:Poisoning / Q000235:genetics / Q000266:history / Q000378:metabolism; D014116:Toxicology / Q000266:history / Q000379:methods*
keywords: dose; historical; metabolism; poisons; toxicity; toxicology; variation