title: Neonatal Hypoxia Results in Peripheral Nerve Abnormalities.
abstract: Although the adverse effects of neonatal hypoxia associated with premature birth on the central nervous system are well known, the contribution of hypoxic damage to the peripheral nervous system (PNS) has not been addressed. We demonstrate that neonatal hypoxia results in hypomyelination and delayed axonal sorting in mice leading to electrophysiological and motor deficits that persist into adulthood. These findings support a potential role for PNS hypoxic damage in the motor impairment that results from premature birth and suggest that therapies designed to protect the PNS may provide clinical benefit.
authors.affiliation: Department of Neurology, The University of Chicago Center for Peripheral Neuropathy, The University of Chicago, Chicago, Illinois.
authors.forename: Benjamin L L
authors.initials: BL
authors.lastname: Clayton
authors.affiliation: Department of Neurology, The University of Chicago Center for Peripheral Neuropathy, The University of Chicago, Chicago, Illinois.
authors.forename: Aaron
authors.initials: A
authors.lastname: Huang
authors.affiliation: Department of Neurology, The University of Chicago Center for Peripheral Neuropathy, The University of Chicago, Chicago, Illinois.
authors.forename: Danuta
authors.initials: D
authors.lastname: Dukala
authors.affiliation: Department of Neurology, The University of Chicago Center for Peripheral Neuropathy, The University of Chicago, Chicago, Illinois.
authors.forename: Betty
authors.initials: B
authors.lastname: Soliven
authors.affiliation: Department of Neurology, The University of Chicago Center for Peripheral Neuropathy, The University of Chicago, Chicago, Illinois. Electronic address: bpopko@neurology.bsd.uchicago.edu.
authors.forename: Brian
authors.initials: B
authors.lastname: Popko
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001369:Axons / Q000473:pathology* / Q000648:ultrastructure; D004195:Disease Models, Animal; D004594:Electrophysiology; D005260:Female; D000860:Hypoxia / Q000473:pathology*; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D046529:Microscopy, Electron, Transmission; D009186:Myelin Sheath / Q000473:pathology* / Q000648:ultrastructure; D060888:Real-Time Polymerase Chain Reaction; D012584:Sciatic Nerve / Q000473:pathology* / Q000503:physiopathology / Q000648:ultrastructure