title: Copper Complexes as Bioinspired Models for Lytic Polysaccharide Monooxygenases.
abstract: We report here two copper complexes as first functional models for lytic polysaccharide monooxygenases, mononuclear copper-containing enzymes involved in recalcitrant polysaccharide breakdown. These complexes feature structural and spectroscopic properties similar to those of the enzyme. In addition, they catalyze oxidative cleavage of the model substrate p-nitrophenyl-β-d-glucopyranoside. More importantly, a particularly stable copper(II) hydroperoxide intermediate is detected in the reaction conditions.
authors.affiliation: Aix Marseille Univ, CNRS , Centrale Marseille, iSm2, Marseille, France.
authors.forename: Alda Lisa
authors.initials: AL
authors.lastname: Concia
authors.affiliation: Aix Marseille Univ, CNRS, BIP , Marseille, France.
authors.forename: Maria Rosa
authors.initials: MR
authors.lastname: Beccia
authors.affiliation: Aix Marseille Univ, CNRS , Centrale Marseille, iSm2, Marseille, France.
authors.forename: Maylis
authors.initials: M
authors.lastname: Orio
authors.affiliation: Instituto de Química, Universidade Federal do Rio de Janerio, Ilha da Cidade Universitária , 219414-909 Rio de Janeiro, Brazil.
authors.forename: Francine Terra
authors.initials: FT
authors.lastname: Ferre
authors.affiliation: Instituto de Química, Universidade Federal do Rio de Janerio, Ilha da Cidade Universitária , 219414-909 Rio de Janeiro, Brazil.
authors.forename: Marciela
authors.initials: M
authors.lastname: Scarpellini
authors.affiliation: Aix Marseille Univ, CNRS, BIP , Marseille, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Biaso
authors.affiliation: Aix Marseille Univ, CNRS, BIP , Marseille, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Guigliarelli
authors.affiliation: Aix Marseille Univ, CNRS , Centrale Marseille, iSm2, Marseille, France.
authors.forename: Marius
authors.initials: M
authors.lastname: Réglier
authors.affiliation: Aix Marseille Univ, CNRS , Centrale Marseille, iSm2, Marseille, France.
authors.forename: A Jalila
authors.identifier: http://orcid.org/0000-0003-2537-0422
authors.initials: AJ
authors.lastname: Simaan
mesh_terms: D055162:Biocatalysis; D003300:Copper / Q000737:chemistry* / Q000378:metabolism; D006899:Mixed Function Oxygenases / Q000737:chemistry* / Q000378:metabolism; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry* / Q000378:metabolism; D011134:Polysaccharides / Q000737:chemistry* / Q000378:metabolism; D011789:Quantum Theory; D055327:Thermoascus / Q000201:enzymology
chemical_list: D009942:Organometallic Compounds; D011134:Polysaccharides; D003300:Copper; D006899:Mixed Function Oxygenases