title: Three-dimensional printing of a microneedle array on personalized curved surfaces for dual-pronged treatment of trigger finger.
abstract: The hand function of patients who suffer from trigger finger can be impaired by the use of traditional splints. There is also a risk of systemic side effects with oral non-steroidal anti-inflammatory drugs (NSAIDs) used for pain relief. Microneedle-assisted transdermal drug delivery offers an attractive alternative for local delivery of NSAIDs. However, traditional microneedle arrays fabricated on flat surfaces are unable to deliver drugs effectively across the undulating skin surface of affected finger(s). In this study, using 3D printing, a dual-function microneedle array has been fabricated on personalized curved surfaces (microneedle splint) for drug delivery and splinting of the affected finger. The novel microneedle splint was assessed for its physical characteristics and the microneedles were shown to withstand up to twice the average thumb force without fracturing. An average skin penetration efficiency of 64% on dermatomed human cadaver skin was achieved and the final microneedle splint showed biocompatibility with human dermal cell lines. A significantly higher amount of diclofenac permeated through the skin by 0.5 h with the use of the microneedle splint as compared to intact skin. The fabricated microneedle splint can thus be a potential new approach to treat trigger finger via personalized splinting without affecting normal hand function.
authors.affiliation: Department of Pharmacy, Faculty of Science, National University of Singapore, Block S4A, Level 3, 18 Science Drive 4, Singapore 117543.
authors.forename: Seng Han
authors.initials: SH
authors.lastname: Lim
authors.forename: Jian Yao
authors.initials: JY
authors.lastname: Ng
authors.forename: Lifeng
authors.initials: L
authors.lastname: Kang
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000378:metabolism / Q000627:therapeutic use; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology; D062028:Bioprinting / Q000379:methods*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D017076:Computer-Aided Design; D004008:Diclofenac / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use; D004337:Drug Carriers / Q000737:chemistry*; D006801:Humans; D009339:Needles; D066330:Printing, Three-Dimensional; D012867:Skin / Q000378:metabolism / Q000473:pathology; D052582:Trigger Finger Disorder / Q000188:drug therapy / Q000473:pathology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001672:Biocompatible Materials; D004337:Drug Carriers; D004008:Diclofenac