title: Preparation of curcumin-loaded PCL-PEG-PCL triblock copolymeric nanoparticles by a microchannel technology.
abstract: Biodegradable polymeric nanoparticles (NPs) have potential therapeutic applications; however, preparing NPs of a specific diameter and uniform size distribution is a challenge. In this work, we fabricated a microchannel system for the preparation of curcumin (Cur)-loaded NPs by the interfacial precipitation method, which rapidly and consistently generated stable NPs with a relatively smaller diameter, narrow size distribution, and higher drug-loading capacity and entrapment efficiency. Poly(ε-caprolactone)-poly(ethylene glycol)-poly (ε-caprolactone) triblock copolymers(PCEC) used as the carrier material was synthesized and characterized. Cur-loaded PCEC NPs had an average size of 167.2nm with a zeta potential of -29.23mV, and showed a loading capacity and drug entrapment efficiency of 15.28%±0.23% and 96.11%±0.13%, respectively. Meanwhile, the NPs demonstrated good biocompatibility and bioavailability, efficient cellular uptake, and long circulation time and a possible liver targeting effect in vivo. These results indicate that the Cur-loaded PCEC NPs can be used as drug carriers in controlled delivery systems and other biomedical applications.
authors.affiliation: College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China.
authors.forename: Fangyuan
authors.initials: F
authors.lastname: Guo
authors.affiliation: College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China.
authors.forename: Dingjia
authors.initials: D
authors.lastname: Guo
authors.affiliation: College of Mechanical Engineering, Zhejiang University of Technology, Hangzhou 310014, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China.
authors.forename: Qinying
authors.initials: Q
authors.lastname: Yan
authors.affiliation: College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Taizhou Municipal Hospital of Zhejiang Province, Taizhou 318000, China.
authors.forename: Weiyong
authors.initials: W
authors.lastname: Hong
authors.affiliation: College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China. Electronic address: yanggs@zjut.edu.cn.
authors.forename: Gensheng
authors.initials: G
authors.lastname: Yang
mesh_terms: D002208:Caproates / Q000737:chemistry; D003474:Curcumin / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods; D007783:Lactones / Q000737:chemistry; D053758:Nanoparticles; D010316:Particle Size; D011091:Polyesters / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*
chemical_list: D002208:Caproates; D004337:Drug Carriers; D007783:Lactones; D011091:Polyesters; D011108:Polymers; C515340:poly(epsilon-caprolactone)-b-poly(ethyleneglycol)-b-poly(epsilon-caprolactone); C016240:polycaprolactone; D011092:Polyethylene Glycols; C121056:caprolactone; D003474:Curcumin
keywords: Amphiphilic copolymer; Biodegradable nanoparticles; Curcumin; Microchannels; Pharmacokinetics