title: Identification and characterization a novel HLA-A allele, A*02:355, by sequence-based typing in a Chinese potential donor.
abstract: The new allele A*02:355 differs from A* 02:03:01 at positions 98 (T→A) and 102(A→C) resulting in an amino acid exchange F9→T. Interallelic sequence exchange is more likely the mechanism of its origination. The amino acid replacement influences the HLA peptide binding cleft and might have significant functional effects.
authors.affiliation: Department of Central Laboratory, Shandong Provincial Hospital affiliated to Shandong University, Jinan, China.|HLA Laboratory, Blood Center of Shandong Province, Jinan, China.
authors.forename: X-M
authors.initials: XM
authors.lastname: Nie
authors.affiliation: HLA Laboratory, Blood Center of Shandong Province, Jinan, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: HLA Laboratory, Blood Center of Shandong Province, Jinan, China.
authors.forename: W-B
authors.initials: WB
authors.lastname: Qiao
authors.affiliation: HLA Laboratory, Blood Center of Shandong Province, Jinan, China.
authors.forename: C-F
authors.initials: CF
authors.lastname: Zhu
authors.affiliation: Department of Central Laboratory, Shandong Provincial Hospital affiliated to Shandong University, Jinan, China.
authors.forename: Y-R
authors.initials: YR
authors.lastname: Zhao
mesh_terms: D000483:Alleles; D019943:Amino Acid Substitution; D044466:Asian People; D001483:Base Sequence; D005091:Exons; D015870:Gene Expression; D015789:HLA-A2 Antigen / Q000235:genetics* / Q000276:immunology; D018380:Hematopoietic Stem Cell Transplantation; D006650:Histocompatibility Testing; D006801:Humans; D009154:Mutation; D017422:Sequence Analysis, DNA; D014019:Tissue Donors
chemical_list: C524866:HLA-A*02 antigen; D015789:HLA-A2 Antigen