title: Cytotoxic lanostane-type triterpenoids from the fruiting bodies of Ganoderma lucidum and their structure-activity relationships.
abstract: We conducted a study of Ganoderma lucidum metabolites and isolated 35 lanostane-type triterpenoids, including 5 new ganoderols (1-5). By spectroscopy, we compared the structures of these compounds with known related compounds in this group. All of the isolated compounds were assayed for their effect against the human breast carcinoma cell line MDA-MB-231 and hepatocellular carcinoma cell line HepG2. Corresponding three-dimensional quantitative structure-activity relationship (3D-QSAR) models were built and analyzed using Discovery Studio. These results provide further evidence for anti-cancer constituents within Ganoderma lucidum, and may provide a theoretical foundation for designing novel therapeutic compounds.
authors.affiliation: State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Institute of Microbiology, Guangzhou, China.|Yuewei Edible Fungi Technology Co. Ltd., Guangzhou, China.
authors.forename: Shaodan
authors.initials: S
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Institute of Microbiology, Guangzhou, China.|Yuewei Edible Fungi Technology Co. Ltd., Guangzhou, China.
authors.forename: Xiangmin
authors.initials: X
authors.lastname: Li
authors.affiliation: State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Institute of Microbiology, Guangzhou, China.|Yuewei Edible Fungi Technology Co. Ltd., Guangzhou, China.
authors.forename: Tianqiao
authors.initials: T
authors.lastname: Yong
authors.affiliation: College of Chinese Materia Medica, Guangzhou University of Traditional Chinese Medicine, Guangzhou, China.
authors.forename: Zhanggen
authors.initials: Z
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Institute of Microbiology, Guangzhou, China.|Yuewei Edible Fungi Technology Co. Ltd., Guangzhou, China.
authors.forename: Jiyan
authors.initials: J
authors.lastname: Su
authors.affiliation: Yuewei Edible Fungi Technology Co. Ltd., Guangzhou, China.
authors.forename: Chunwei
authors.initials: C
authors.lastname: Jiao
authors.affiliation: State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Institute of Microbiology, Guangzhou, China.|Yuewei Edible Fungi Technology Co. Ltd., Guangzhou, China.
authors.forename: Yizhen
authors.initials: Y
authors.lastname: Xie
authors.affiliation: Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Canada.|Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.
authors.forename: Burton B
authors.initials: BB
authors.lastname: Yang
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000473:pathology; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D048690:Fruiting Bodies, Fungal / Q000737:chemistry*; D056945:Hep G2 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008968:Molecular Conformation; D062105:Molecular Docking Simulation; D021281:Quantitative Structure-Activity Relationship; D020940:Reishi / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D014315:Triterpenes
keywords: 3D-QSAR; Ganoderma lucidum; cytotoxicity; lanostane-type triterpenoids