title: Gene therapy for heart failure.
abstract: Novel strategies are needed to treat the growing population of heart failure patients. While new drug and device based therapies have improved outcomes over the past several decades, heart failure patients continue to experience amongst the lowest quality of life of any chronic disease, high likelihood of being hospitalized and marked reduction in survival. Better understanding of many of the basic mechanisms involved in the development of heart failure has helped identify abnormalities that could potentially be targeted by gene transfer. Despite success in experimental animal models, translating gene transfer strategies from the laboratory to the clinic remains at an early stage. This review provides an introduction to gene transfer as a therapy for treating heart failure, describes some of the many factors that need to be addressed in order for it to be successful and discusses some of the recent studies that have been carried out in heart failure patients. Insights from these studies highlight both the enormous promise of gene transfer and the obstacles that still need to be overcome for this treatment approach to be successful.
authors.affiliation: University of California, San Diego, La Jolla, CA, USA. Electronic address: bgreenberg@ucsd.edu.
authors.forename: Barry
authors.initials: B
authors.lastname: Greenberg
mesh_terms: D000256:Adenoviridae / Q000235:genetics; D000262:Adenylyl Cyclases / Q000096:biosynthesis / Q000235:genetics; D000818:Animals; D054377:Chemokine CXCL12 / Q000096:biosynthesis / Q000235:genetics; D000229:Dependovirus / Q000235:genetics; D005786:Gene Expression Regulation; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors; D006333:Heart Failure / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases / Q000096:biosynthesis / Q000235:genetics; D016896:Treatment Outcome
chemical_list: C515255:CXCL12 protein, human; D054377:Chemokine CXCL12; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases; D000262:Adenylyl Cyclases; C121100:adenylyl cyclase 6; C506946:ATP2A2 protein, human
keywords: Adeno-associated virus; Gene therapy; Heart failure; SERCA2a