title: Chemoselective Reduction and Alkylation of Carbonyl Functions Using Phosphonium Salts as an in Situ Protecting Groups.
abstract: Recent progress in the chemoselective reduction and alkylation of carbonyl functions using our in situ protection method is described. Methods that enable reversal or control of the reactivity of a carbonyl functional group are potentially useful. They open up new areas of synthetic organic chemistry and change the concept of retrosynthesis because they remove the need for complicated protection/deprotection sequences. In this account, we discuss the strategy and applications of our in situ protection method using phosphonium salts.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Osaka University.
authors.forename: Reiya
authors.initials: R
authors.lastname: Ohta
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Fujioka
mesh_terms: D000447:Aldehydes / Q000138:chemical synthesis* / Q000737:chemistry; D000478:Alkylation; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000737:chemistry*; D010084:Oxidation-Reduction; D012492:Salts / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D007659:Ketones; D009943:Organophosphorus Compounds; D012492:Salts