title: Neonatal lupus erythematosus with congenital heart block in twins.
abstract: Background - Neonatal lupus erythematosus is an uncommon acquired autoimmune disease caused by transplacental passage of maternal antibodies SSA/Ro, SSB/La or U1 ribonucleoproteins. The most common clinical manifestations are skin rash, cardiac lesions, thrombocytopenia, anemia and hepatosplenomegaly. Complete congenital heart block is usually irreversible needing a pacemaker implantation in two-thirds of cases. Cases report - We report neonatal lupus erythematosus with complete congenital heart block in twins. Newborns were delivered by caesarean section at week 38 of gestation with a heart rate regular at 70 beats per minute. Both twins and mother were positive for antinuclear, anti-SSA, and anti-SSB antibodies. Twins received single-chamber pacemaker implants at day 12 of life. The evolution was immediately favorable with a heart rate around 110 beats per minute. The follow-up was 2 years. The twins are currently asymptomatic. Conclusion - Complete congenital heart block is the most serious manifestation of the neonatal lupus erythematosus associated with significant morbidity and mortality.
authors.forename: Lamia
authors.initials: L
authors.lastname: Gargouri
authors.forename: Faiza
authors.initials: F
authors.lastname: Safi
authors.forename: Bayen
authors.initials: B
authors.lastname: Maalej
authors.forename: Souad
authors.initials: S
authors.lastname: Mallek
authors.forename: Fatma
authors.initials: F
authors.lastname: Turki
authors.forename: Imen
authors.initials: I
authors.lastname: Majdoub
authors.forename: Malek
authors.initials: M
authors.lastname: Akrout
authors.forename: Dorra
authors.initials: D
authors.lastname: Abid
authors.forename: Samir
authors.initials: S
authors.lastname: Kamoun
authors.forename: Abdelmajid
authors.initials: A
authors.lastname: Mahfoudh
mesh_terms: D000974:Antibodies, Antinuclear; D002585:Cesarean Section; D004200:Diseases in Twins / Q000150:complications* / Q000628:therapy; D005260:Female; D006327:Heart Block / Q000150:complications / Q000151:congenital* / Q000628:therapy; D006801:Humans; D007231:Infant, Newborn; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000151:congenital* / Q000276:immunology; D010138:Pacemaker, Artificial; D011247:Pregnancy
chemical_list: D000974:Antibodies, Antinuclear