title: Linking metabolic reprogramming to therapy resistance in cancer.
abstract: Metabolic rearrangements are essential to satisfy the different requirements of cancer cells during tumorigenesis and recent studies have highlighted a role for such metabolic reprogramming in response and adaptation to therapies. However, therapy-resistant experimental models have been described to be either glycolysis-dependent or OXPHOS-addicted. Here we discuss the recent literature on metabolic reprogramming of cancer in therapy resistance with a plausible explanation of the observed differences which collectively indicate that dis-regulated metabolic pathways could be considered potential therapeutic targets in tumors resistant to conventional therapy.
authors.affiliation: Department of Experimental and Clinical Biomedical Sciences, University of Florence, viale GB Morgagni 50, Florence 50134, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Morandi
authors.affiliation: Istituto Oncologico Veneto - IRCCS, via Gattamelata, 64, Padova 35128, Italy. Electronic address: stefano.indraccolo@unipd.it.
authors.forename: Stefano
authors.initials: S
authors.lastname: Indraccolo
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000378:metabolism* / Q000473:pathology*; D065150:Cellular Reprogramming / Q000502:physiology*; D019008:Drug Resistance, Neoplasm / Q000502:physiology*; D006019:Glycolysis / Q000502:physiology; D006801:Humans; D053858:Metabolic Networks and Pathways / Q000502:physiology*; D009369:Neoplasms / Q000378:metabolism*; D010085:Oxidative Phosphorylation
keywords: Metabolic reprogramming; OXPHOS; Therapy resistance; Warburg metabolism