title: Serum ApoB levels in depressive patients: associated with cognitive deficits.
abstract: Cognitive deficits have been regarded as one of the most significant clinical symptoms of depressive disorder. Accumulating evidence has shown that apolipoprotein B (ApoB) levels, which are responsible for inducing neurodegeneration, may be involved in cognitive deficits. This study examines cognitive deficits, and the correlation of serum ApoB levels with cognitive deficits of depressive disorder. 90 depressive patients and 90 healthy controls with matched age and gender were recruited. Cognition was assessed using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Serum ApoB levels in depressive patients were measured by immunoturbidimetric method. Our results showed that depressive patients had lower scores of cognition including RBANS total score and subscales of language and delayed memory (all, p < 0.001) than healthy controls after controlling for the variables. The differences in cognitive functions also passed Bonferroni corrections. Serum ApoB levels were negatively correlated with delayed memory score in depressive patients (r = -0.30, p = 0.01). Furthermore, stepwise multivariate regression analysis indicated that serum ApoB levels independently contributed to delayed memory in depressive patients (t = -2.68, p = 0.01). Our findings support that serum ApoB levels may be involved in delayed memory decline in depressive patients. Depressive patients also experience greater cognitive deficits, especially in delayed memory and language than healthy controls.
authors.affiliation: Institute of Mental Health, Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou 215008, Jiangsu, PR China.
authors.forename: Li
authors.initials: L
authors.lastname: Hui
authors.affiliation: School of Medicine, IHMRI, University of Wollongong, Wollongong, NSW 2522, Australia.
authors.forename: Mei
authors.initials: M
authors.lastname: Han
authors.affiliation: Institute of Mental Health, Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou 215008, Jiangsu, PR China.
authors.forename: Xiang Dong
authors.initials: XD
authors.lastname: Du
authors.affiliation: Beijing HuilongGuan Hospital, Peking University, Beijing 100096, PR China.
authors.forename: Bao Hua
authors.initials: BH
authors.lastname: Zhang
authors.affiliation: Department of Psychology, Peking University, Beijing 100000, PR China.
authors.forename: Shu Chang
authors.initials: SC
authors.lastname: He
authors.affiliation: Institute of Mental Health, Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou 215008, Jiangsu, PR China.
authors.forename: Tian Nan
authors.initials: TN
authors.lastname: Shao
authors.affiliation: Institute of Mental Health, Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou 215008, Jiangsu, PR China.
authors.forename: Guang Zhong
authors.initials: GZ
authors.lastname: Yin
mesh_terms: D000328:Adult; D053299:Apolipoprotein B-100 / Q000097:blood*; D001774:Blood Chemical Analysis; D003072:Cognition Disorders / Q000473:pathology*; D003863:Depression / Q000150:complications*; D005260:Female; D006801:Humans; D000074024:Immunoturbidimetry; D008297:Male; D044967:Serum / Q000737:chemistry*; D055815:Young Adult
chemical_list: C569471:APOB protein, human; D053299:Apolipoprotein B-100