title: Targeting IRES-Mediated p53 Synthesis for Cancer Diagnosis and Therapeutics.
abstract: While translational regulation of p53 by the internal ribosome entry site (IRES) at its 5'-untranslated region following DNA damage has been widely accepted, the detailed mechanism underlying the translational control of p53 by its IRES sequence is still poorly understood. In this review, we will focus on the latest progress in identifying novel regulatory proteins of the p53 IRES and in uncovering the functional connection between defective IRES-mediated p53 translation and tumorigenesis. We will also discuss how these findings may lead to a better understanding of the process of oncogenesis and open up new avenues for cancer diagnosis and therapeutics.
authors.affiliation: Department of Hepatobiliary and Pancreatic Surgery, the First Hospital of Jilin University, Changchun 130021, China. bji@hi.umn.edu.|The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA. bji@hi.umn.edu.
authors.forename: Bai
authors.initials: B
authors.lastname: Ji
authors.affiliation: The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA. brharris@umn.edu.
authors.forename: Benjamin R E
authors.initials: BR
authors.lastname: Harris
authors.affiliation: Department of Hepatobiliary and Pancreatic Surgery, the First Hospital of Jilin University, Changchun 130021, China. jirulin@sina.com.
authors.forename: Yahui
authors.initials: Y
authors.lastname: Liu
authors.affiliation: The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA. yideng@hi.umn.edu.|The Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA. yideng@hi.umn.edu.
authors.forename: Yibin
authors.initials: Y
authors.lastname: Deng
authors.affiliation: The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA. sgradilone@hi.umn.edu.|The Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA. sgradilone@hi.umn.edu.
authors.forename: Sergio A
authors.initials: SA
authors.lastname: Gradilone
authors.affiliation: The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA. mpcleary@hi.umn.edu.|The Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA. mpcleary@hi.umn.edu.
authors.forename: Margot P
authors.initials: MP
authors.lastname: Cleary
authors.affiliation: Department of Hepatobiliary and Pancreatic Surgery, the First Hospital of Jilin University, Changchun 130021, China. jirulin@yeah.net.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Liu
authors.affiliation: The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA. dyang@umn.edu.|The Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA. dyang@umn.edu.
authors.forename: Da-Qing
authors.initials: DQ
authors.lastname: Yang
mesh_terms: D020121:5' Untranslated Regions; D000818:Animals; D063646:Carcinogenesis / Q000235:genetics; D004249:DNA Damage; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D000067556:Internal Ribosome Entry Sites; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics*; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000235:genetics; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: D020121:5' Untranslated Regions; D000067556:Internal Ribosome Entry Sites; D012333:RNA, Messenger; D016159:Tumor Suppressor Protein p53
keywords: DNA damage; IRES-trans acting factors (ITAFs); internal ribosome entry site (IRES); p53