title: Evaluation of Ophthalmic Artery Branch Retrograde Intervention in the Treatment of Central Retinal Artery Occlusion (CRAO).
abstract: BACKGROUND Central retinal artery occlusion (CRAO) is the occlusion of the central retinal artery resulting in retinal infarction and acute vision loss. Digital subtraction angiography (DSA)-guided superselective ophthalmic artery or selective carotid thrombolysis remains the preferred treatment method for CRAO. This study aimed to evaluate the safety and clinical efficacy of the novel ophthalmic artery branch retrograde thrombolytic intervention for CRAO. MATERIAL AND METHODS Fifty patients with monocular CRAO were enrolled, including 28 males and 22 females (mean age: 55.7±2.3 years). The patients were randomly divided into two groups for thrombolysis with urokinase (400,000 U) and papaverine (30 mg) by either ophthalmic artery branch retrograde intervention (group A, n=26) or superselective ophthalmic artery/selective carotid intervention (group B, n=24). There was no significant difference in age (P=0.58), gender ratio (P=0.49), and time to onset (P=1.00) between the two groups. The adverse reactions and clinical efficacy were evaluated by postoperative DSA, fundus fluorescein angiography (FFA), and visual acuity tests. RESULTS No serious complications, abnormal eye movement, or vitreous hemorrhage occurred in either group. DSA showed that group A had an effective rate (92.30%) comparable to that of group B (100%, χ²=2.08, P=0.25). FFA suggested that both groups had similar treatment efficacy (χ²=3.09, P=0.21). Visual acuity tests also confirmed a similar efficacy of the two intervention approaches (χ²=0.25, P=0.88). CONCLUSIONS The developed novel ophthalmic artery branch retrograde intervention is highly effective and safe for CRAO, and may be a superior method compared with the conventional approach.
authors.affiliation: Department of Ophthalmology, The Fourth Hospital of Xian, Xian, Shaanxi, China (mainland).
authors.forename: Runsheng
authors.initials: R
authors.lastname: Wang
authors.affiliation: Department of Medicine, The Fourth Hospital of Xian, Xian, Shaanxi, China (mainland).
authors.forename: Lu
authors.initials: L
authors.lastname: Qian
authors.affiliation: Department of Interventional Radiology, The Fourth Hospital of Xian, Xian, Shaanxi, China (mainland).
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Interventional Radiology, The Fourth Hospital of Xian, Xian, Shaanxi, China (mainland).
authors.forename: Yi
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: Department of Ophthalmology, The Fourth Hospital of Xian, Xian, Shaanxi, China (mainland).
authors.forename: Shanshuang
authors.initials: S
authors.lastname: Du
authors.affiliation: Department of Medicine, The Fourth Hospital of Xian, Xian, Shaanxi, China (mainland).
authors.forename: Tao
authors.initials: T
authors.lastname: Lei
authors.affiliation: Department of Ophthalmology, The First Hospital of Xian, Xian, Shaanxi, China (mainland).
authors.forename: Peilin
authors.initials: P
authors.lastname: Lv
authors.affiliation: Department of Ophthalmology, The First Hospital of Xian, Xian, Shaanxi, China (mainland).
authors.forename: Tan
authors.initials: T
authors.lastname: Long
authors.affiliation: Department of Ophthalmology, The Fourth Hospital of Xian, Xian, Shaanxi, China (mainland).
authors.forename: Wenjun
authors.initials: W
authors.lastname: Wang
mesh_terms: D015901:Angiography, Digital Subtraction / Q000379:methods; D057510:Endovascular Procedures / Q000379:methods*; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008297:Male; D008875:Middle Aged; D009880:Ophthalmic Artery / Q000601:surgery*; D010208:Papaverine / Q000627:therapeutic use; D015356:Retinal Artery Occlusion / Q000628:therapy*; D015912:Thrombolytic Therapy / Q000379:methods; D016896:Treatment Outcome; D014568:Urokinase-Type Plasminogen Activator / Q000627:therapeutic use; D014792:Visual Acuity
chemical_list: D010208:Papaverine; D014568:Urokinase-Type Plasminogen Activator