title: Effects of stem cell transplantation on bone mineral density and vitamin D status in children with thalassemia major.
abstract: HSCT is a curative treatment in TM, but conditioning and immunosuppressive treatment may affect bone metabolism. In this retrospective study, we aimed to compare BMD, vitamin D status, and growth in children with TM who underwent HSCT to those in children with TD TM. Twenty-three children with TM who underwent HSCT (mean age 7.1 years [1.03-14.7]) and 24 children with TD thalassemia (mean age 9.8 years [1.6-14]) were recruited. Lumbar spine BMD of TD thalassemia patients was higher than those in patients who had HSCT at both baseline and second-year assessments (P=.009, P<.001, respectively). However, BMD Z scores or serum 25-OH vitamin D levels were not different in two groups. Being >10 years of age was a significant risk factor for low BMD, height, and weight Z score for both groups. Patients who underwent HSCT with Pesaro risk class II or III had higher risk for low BMD compared to those risk class I patients (P=.044). In conclusion, children with TM who were >10 years at HSCT are at risk for low BMD and growth retardation. HSCT had no effect on BMD deficit in children with TM.
authors.affiliation: Department of Pediatric Hematology, Ankara Children's Hematology and Oncology Hospital, Ankara, Turkey.
authors.forename: Dilek
authors.initials: D
authors.lastname: Gürlek Gökçebay
authors.affiliation: Department of Pediatric Hematology, Ankara Children's Hematology and Oncology Hospital, Ankara, Turkey.
authors.forename: Namik
authors.initials: N
authors.lastname: Ozbek
authors.affiliation: Department of Pediatric Hematology, Ankara Children's Hematology and Oncology Hospital, Ankara, Turkey.
authors.forename: Arzu
authors.initials: A
authors.lastname: Yazal Erdem
authors.affiliation: Department of Pediatric Hematology, Ankara Children's Hematology and Oncology Hospital, Ankara, Turkey.
authors.forename: Vildan
authors.initials: V
authors.lastname: Culha
authors.affiliation: Department of Pediatric Hematology, Ankara Children's Hematology and Oncology Hospital, Ankara, Turkey.
authors.forename: Nese
authors.initials: N
authors.lastname: Yarali
authors.affiliation: Department of Pediatric Hematology, Ankara Children's Hematology and Oncology Hospital, Ankara, Turkey.
authors.forename: Pamir
authors.initials: P
authors.lastname: Isik
authors.affiliation: Department of Pediatric Hematology, Ankara Children's Hematology and Oncology Hospital, Ankara, Turkey.
authors.forename: Zekai
authors.initials: Z
authors.lastname: Avci
authors.affiliation: Department of Pediatric Hematology, Ankara Children's Hematology and Oncology Hospital, Ankara, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Azik
authors.affiliation: Department of Pediatric Endocrinology and Metabolism, Ankara Children's Hematology and Oncology Hospital, Ankara, Turkey.
authors.forename: Fatma
authors.initials: F
authors.lastname: Demirel
authors.affiliation: Department of Pediatric Hematology, Ankara Children's Hematology and Oncology Hospital, Ankara, Turkey.
authors.forename: Bahattin
authors.initials: B
authors.lastname: Tunc
mesh_terms: D015502:Absorptiometry, Photon; D000293:Adolescent; D001835:Body Weight; D015519:Bone Density; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007223:Infant; D008159:Lumbar Vertebrae / Q000187:drug effects; D008297:Male; D012189:Retrospective Studies; D012307:Risk Factors; D033581:Stem Cell Transplantation; D013997:Time Factors; D014807:Vitamin D / Q000097:blood*; D017086:beta-Thalassemia / Q000097:blood* / Q000628:therapy
chemical_list: D007166:Immunosuppressive Agents; D014807:Vitamin D
keywords: bone mineral density; children; stem cell transplantation; thalassemia major