title: Evaluation of the Antioxidant Capacities and Cytotoxic Effects of TenParmeliaceaeLichen Species.
abstract: Parmeliaceae represents the largest and widespread family of lichens and includes species that attract much interest regarding pharmacological activities, due to their production of unique secondary metabolites. The current work aimed to investigate thein vitroantioxidant and cytotoxic activities of the methanol extracts of ten Parmeliaceae species, collected in different continents. Methanol extraction afforded high phenolic content in the extracts. The antioxidant activity displayed by lichens was evaluated through chemical assays, such as the ORAC (Oxygen Radical Absorbance Capacity) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities and the ferric reducing antioxidant power (FRAP). A moderately positive correlation was found between the phenolic content and the antioxidant properties for all the species:R: 0.7430 versus ORAC values,R: 0.7457 versus DPPH scavenging capacity, andR: 0.7056 versus FRAP reducing power. The methanol extract ofFlavoparmelia euplectaexhibited the highest ORAC value, the extract ofMyelochroa irrugansshowed the maximum DPPH scavenging capacity, andHypotrachyna cirrhatamethanol extract demonstrated the highest reducing power. Further, the cytotoxic activity of the ten species was investigated on the human cancer cell lines HepG2 and MCF-7;Myelochroa irrugansexhibited the highest anticancer potential. The pharmacological activities shown here could be attributed to their phytochemical constituents.
authors.affiliation: Department of Pharmacology, Faculty of Pharmacy, University Complutense of Madrid, Plaza Ramón y Cajal s/n, 28040 Madrid, Spain.
authors.forename: C
authors.identifier: 0000-0002-9649-4070
authors.initials: C
authors.lastname: Fernández-Moriano
authors.affiliation: Department of Pharmacology, Faculty of Pharmacy, University Complutense of Madrid, Plaza Ramón y Cajal s/n, 28040 Madrid, Spain.
authors.forename: E
authors.initials: E
authors.lastname: González-Burgos
authors.affiliation: Department of Plant Biology II, Faculty of Pharmacy, University Complutense of Madrid, Plaza Ramón y Cajal s/n, 28040 Madrid, Spain.
authors.forename: P K
authors.initials: PK
authors.lastname: Divakar
authors.affiliation: Department of Plant Biology II, Faculty of Pharmacy, University Complutense of Madrid, Plaza Ramón y Cajal s/n, 28040 Madrid, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Crespo
authors.affiliation: Department of Pharmacology, Faculty of Pharmacy, University Complutense of Madrid, Plaza Ramón y Cajal s/n, 28040 Madrid, Spain.
authors.forename: M P
authors.identifier: 0000-0002-9178-3420
authors.initials: MP
authors.lastname: Gómez-Serranillos