title: Retrospective study of degenerative mitral valve disease in small-breed dogs: survival and prognostic variables.
abstract: Small-breed dogs (n = 168; weight ＜ 15 kg) diagnosed with myxomatous mitral valve degeneration based on a routine clinical examination, radiology, electrocardiography, and echocardiography at the Seoul National University Veterinary Medical Teaching Hospital were included in this study. Survival periods were determined, and there were significant differences in survival rates among the three International Small Animal Cardiac Health Council classes. The mean follow-up period was 14.3 ± 12.1 months. Univariate analysis revealed that dyspnea, pulmonary edema, and vertebral heart score were significantly associated with survival time (p＜ 0.05). Additionally, age, left atrial-to-aortic root ratio, ejection fraction, and left ventricular end diastolic volume were associated with an increased risk of death (p＜ 0.1), while body weight, body condition score, systolic blood pressure, arrhythmia, syncope, fractional shortening, and end systolic volume were not associated with an increased risk of death. These results suggest that among the assessed variables dyspnea, pulmonary edema, and vertebral heart score could be useful prognostic factors for providing patient information to owners.
authors.affiliation: Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea.
authors.forename: Hyun-Tae
authors.initials: HT
authors.lastname: Kim
authors.affiliation: Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea.
authors.forename: Sei-Myoung
authors.initials: SM
authors.lastname: Han
authors.affiliation: Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea.
authors.forename: Woo-Jin
authors.initials: WJ
authors.lastname: Song
authors.affiliation: Department of Veterinary Medical Imaging, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea.
authors.forename: Boeun
authors.initials: B
authors.lastname: Kim
authors.affiliation: Department of Veterinary Medical Imaging, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea.
authors.forename: Mincheol
authors.initials: M
authors.lastname: Choi
authors.affiliation: Department of Veterinary Medical Imaging, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea.
authors.forename: Junghee
authors.initials: J
authors.lastname: Yoon
authors.affiliation: Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea.
authors.forename: Hwa-Young
authors.initials: HY
authors.lastname: Youn
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology; D004285:Dogs; D004452:Echocardiography / Q000662:veterinary; D005260:Female; D008297:Male; D008944:Mitral Valve Insufficiency / Q000175:diagnosis / Q000401:mortality / Q000473:pathology / Q000662:veterinary*; D011379:Prognosis; D011859:Radiography / Q000662:veterinary; D012189:Retrospective Studies; D016019:Survival Analysis
keywords: congestive heart failure; mitral valve disease; prognosis; survival rate; vertebral heart score