title: Visible-Light-Triggered Activation of a Protein Kinase Inhibitor.
abstract: A photoresponsive small molecule undergoes a ring-opening reaction when exposed to visible light and becomes an active inhibitor of the enzyme protein kinase C. This "turning on" of enzyme inhibition with light puts control into the hands of the user, creating the opportunity to regulate when and where enzyme catalysis takes place.
authors.affiliation: 4D LABS, Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, BC, V5A 1S6, Canada.
authors.forename: Danielle
authors.identifier: 0000-0002-1298-7995
authors.initials: D
authors.lastname: Wilson
authors.affiliation: 4D LABS, Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, BC, V5A 1S6, Canada.
authors.forename: Jason W
authors.initials: JW
authors.lastname: Li
authors.affiliation: 4D LABS, Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, BC, V5A 1S6, Canada.
authors.forename: Neil R
authors.identifier: 0000-0003-2517-4165
authors.initials: NR
authors.lastname: Branda
mesh_terms: D055162:Biocatalysis; D005030:Ethylenes / Q000737:chemistry; D031541:Fluorescence Resonance Energy Transfer; D007536:Isomerism; D008027:Light; D010455:Peptides / Q000737:chemistry / Q000378:metabolism; D011493:Protein Kinase C / Q000037:antagonists & inhibitors* / Q000378:metabolism; D047428:Protein Kinase Inhibitors / Q000737:chemistry* / Q000378:metabolism / Q000528:radiation effects; D013056:Spectrophotometry, Ultraviolet
chemical_list: D005030:Ethylenes; D010455:Peptides; D047428:Protein Kinase Inhibitors; D011493:Protein Kinase C
keywords: diarylethenes; enzyme inhibitors; photoactivation; photochromism; protein kinase C