title: Global Research Trends in Lithium Toxicity from 1913 to 2015: A Bibliometric Analysis.
abstract: Lithium salts have been used to treat psychiatric disorders since the 1940s and are currently used in prophylaxis and treatment of depression and bipolar disorder. Therefore, we conducted this study to assess lithium toxicity-related publications using bibliometric approaches from a health point of view to assess global research trends in the lithium toxicity field to offer guidance to future research in this field. The data were retrieved from the online version of Scopus database on 6 August 2016. All records with the term 'lithium' in the title were retrieved, and those related to lithium toxicity were evaluated. There were a total of 1241 publications related to lithium toxicity published from 1913 to 2016. Articles (971 or 78.2%) were the most common type, followed by letters (179 or 14.4%) and reviews (61 or 4.9%). The annual publication of articles increased slightly after 1950 and the total number of publications related to lithium toxicity fluctuated with three peaks occurred in 1978, 1985 and 2014. The USA was the predominant country (25.38%), followed by the UK (7.82%), France (6.85%) and Canada (3.55%). Denmark had the highest productivity of publication after standardization by gross domestic product and population size. The average number of citations per article was 9.24, and the h-index for all publications in the field of lithium toxicity was 46. The highest h-index value was achieved by the USA (31) followed by the UK (21) and Canada (13). The Lancet was the highest ranked journal with 27 articles, followed by American Journal of Psychiatry with 23 articles. This study provides a bibliometric analysis on the global research trends in lithium toxicity studies during 1913-2015. There has been a progressive increase in the number of publications related to lithium toxicity published in the last decade, and most of the studies related to lithium toxicity arose from the USA and the UK.
authors.affiliation: Poison Control and Drug Information Center (PCDIC), College of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine.|Department of Clinical and Community Pharmacy, College of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine.
authors.forename: Sa'ed H
authors.initials: SH
authors.lastname: Zyoud
authors.affiliation: Acute Medical Unit, York Teaching Hospitals NHS Foundation Trust, York, UK.
authors.forename: W Stephen
authors.initials: WS
authors.lastname: Waring
authors.affiliation: Department of Pharmacology and Toxicology, College of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine.
authors.forename: Waleed M
authors.initials: WM
authors.lastname: Sweileh
authors.affiliation: Department of Clinical and Community Pharmacy, College of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine.
authors.forename: Samah W
authors.initials: SW
authors.lastname: Al-Jabi
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use / Q000633:toxicity*; D015706:Bibliometrics; D035843:Biomedical Research / Q000706:statistics & numerical data / Q000639:trends*; D001714:Bipolar Disorder / Q000188:drug therapy*; D003866:Depressive Disorder / Q000188:drug therapy*; D006801:Humans; D018020:Lithium Compounds / Q000627:therapeutic use / Q000633:toxicity*
chemical_list: D000928:Antidepressive Agents; D018020:Lithium Compounds