title: Randomized, double-blind, placebo-controlled trial to compare solifenacin versus trospium chloride in the relief of double-J stent-related symptoms.
abstract: OBJECTIVE
  We aimed to compare the safety and efficacy of solifenacin versus trospium chloride and compare each drug versus placebo regarding the relief of stent-related symptoms following uncomplicated ureteroscopic lithotripsy (URSL).
  
  
  METHODS
  In a prospective, randomized, double-blind study, 210 eligible patients who underwent URSL with double-J stent insertion were recruited and randomly assigned to either the first group, receiving solifenacin (10 mg), second group, receiving trospium chloride (60 mg), or the third group, receiving placebo (one tablet). All patients were kept on study medication once daily during the entire 2-week postoperative period. All subjects were asked to complete a brief-form questionnaire to assess the lower urinary symptoms, stent-related body pain and hematuria, preoperatively and 2 weeks postoperatively.
  
  
  RESULTS
  There were no statistically significant differences among the study groups in terms of mean age, gender, anthropometric measurements, stone and stent criteria. The overall symptom score, urgency, urge incontinence, flank pain, urethral pain and gross hematuria scores were significantly lower in solifenacin group compared to trospium chloride and placebo groups (p < 0.001). Concerning frequency and nocturia, there was no significant difference in mean scores across all groups. Drug-related side effects, particularly constipation, were higher in trospium group than in solifenacin one.
  
  
  CONCLUSIONS
  Solifenacin treatment showed significant improvement in almost all domains of stent-related symptoms than trospium. In terms of safety and tolerance, both drugs were comparable. Future studies should be designed to address the impact of combined drugs and lower doses in the management of DJ stent-related symptoms.
authors.affiliation: Department of Urology, Cairo University, Cairo, 11562, Egypt. haythamuro@yahoo.com.
authors.forename: Mohamed H
authors.initials: MH
authors.lastname: Abdelhamid
authors.affiliation: Department of Urology, Theodor Bilharz Research Institute, Giza, 12411, Egypt.
authors.forename: Ahmed S
authors.initials: AS
authors.lastname: Zayed
authors.affiliation: Department of Urology, Cairo University, Cairo, 11562, Egypt.
authors.forename: Waleed E
authors.initials: WE
authors.lastname: Ghoneima
authors.affiliation: Department of Urology, Beni-Suef University, Beni Suef, 62511, Egypt.
authors.forename: Akrm A
authors.initials: AA
authors.lastname: Elmarakbi
authors.affiliation: Department of Urology, Cairo University, Cairo, 11562, Egypt.
authors.forename: Mohamed S
authors.initials: MS
authors.lastname: El Sheemy
authors.affiliation: Department of Urology, Beni-Suef University, Beni Suef, 62511, Egypt.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Aref
authors.affiliation: Department of Urology, Beni-Suef University, Beni Suef, 62511, Egypt.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Abdelbary
authors.affiliation: Department of Urology, Theodor Bilharz Research Institute, Giza, 12411, Egypt.
authors.forename: Hani H
authors.initials: HH
authors.lastname: Nour
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001561:Benzilates / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D021501:Flank Pain / Q000517:prevention & control; D006417:Hematuria / Q000517:prevention & control; D006801:Humans; D007669:Kidney Calculi / Q000628:therapy*; D008096:Lithotripsy / Q000379:methods; D008297:Male; D008875:Middle Aged; D018727:Muscarinic Antagonists / Q000627:therapeutic use*; D053158:Nocturia / Q000517:prevention & control; D009662:Nortropanes / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000517:prevention & control*; D000069464:Solifenacin Succinate / Q000627:therapeutic use*; D015607:Stents; D011795:Surveys and Questionnaires; D018666:Ureteroscopy / Q000379:methods; D053202:Urinary Incontinence, Urge / Q000517:prevention & control*; D055815:Young Adult
chemical_list: D001561:Benzilates; D018727:Muscarinic Antagonists; D009662:Nortropanes; C003330:trospium chloride; D000069464:Solifenacin Succinate
keywords: Laser lithotripsy; Solifenacin; Stent-related symptoms; Trospium chloride; Ureteroscopy