title: The process of mineralisation in the development of human tooth.
abstract: Tooth development and mineralisation are processes that derive from different tissues interactions, in particular ectodermal and mesenchymal layers. These interactions are responsible for the formation of unique structures with a particular chemical composition. Despite differences, mineralised tissues are similar and they derive by highly concerted extracellular processes that involve matrix proteins, proteases, and mineral ion fluxes that collectively regulate the nucleation, growth and organisation of forming mineral crystals. This review aims at explaining mineralisation, its stages and when damage occurs and alters the hard tissues structure.
authors.affiliation: Department of Health, Life and Environmental Sciences, University of L'Aquila.
authors.forename: S
authors.initials: S
authors.lastname: Caruso
authors.affiliation: Department of Health, Life and Environmental Sciences, University of L'Aquila.
authors.forename: S
authors.initials: S
authors.lastname: Bernardi
authors.affiliation: Department of Surgical, Medical, Molecular and Critical Area Pathology, University of Pisa.
authors.forename: M
authors.initials: M
authors.lastname: Pasini
authors.affiliation: Department of Surgical, Medical, Molecular and Critical Area Pathology, University of Pisa.
authors.forename: M R
authors.initials: MR
authors.lastname: Giuca
authors.affiliation: Department of Experimental Medicine and Surgery, University of Rome "Tor Vergata".
authors.forename: R
authors.initials: R
authors.lastname: Docimo
authors.affiliation: Department of Health, Life and Environmental Sciences, University of L'Aquila.
authors.forename: M A
authors.initials: MA
authors.lastname: Continenza
authors.affiliation: Department of Health, Life and Environmental Sciences, University of L'Aquila.
authors.forename: R
authors.initials: R
authors.lastname: Gatto
mesh_terms: D002113:Calcification, Physiologic / Q000502:physiology*; D006801:Humans; D009805:Odontogenesis / Q000502:physiology*; D014071:Tooth Abnormalities / Q000503:physiopathology*