title: Recurrent angioedema associated with pharmacological inhibition of dipeptidyl peptidase IV.
abstract: Angioedema (AE) of the upper airways is a severe and potentially life-threatening condition. The incidence has been increasing in the past two decades, primarily due to increased use of medications inhibiting the degradation of vasoactive peptides. Acquired angioedema related to angiotensin-converting enzyme inhibitors (ACEI-AAE) is well known, but other pharmaceutical agents also affect the degradation of bradykinin and substance P. We present a middle-aged man with recurrent episodes of severe AE of the oral cavity, hypopharynx and larynx due to pharmacological inhibition of dipeptidyl peptidase IV.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen, Denmark.
authors.forename: Thorbjørn
authors.initials: T
authors.lastname: Hermanrud
authors.affiliation: Dermatology and Allergy Center, University Hospital of Odense, Odense, Denmark.
authors.forename: Anette
authors.initials: A
authors.lastname: Bygum
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen, Denmark.
authors.forename: Eva Rye
authors.initials: ER
authors.lastname: Rasmussen
mesh_terms: D000799:Angioedema / Q000139:chemically induced*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects; D003937:Diagnosis, Differential; D054873:Dipeptidyl-Peptidase IV Inhibitors / Q000009:adverse effects*; D004347:Drug Interactions; D006801:Humans; D007013:Hypopharynx / Q000187:drug effects; D007819:Laryngeal Edema / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000139:chemically induced; D010608:Pharyngeal Diseases / Q000139:chemically induced
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D054873:Dipeptidyl-Peptidase IV Inhibitors