title: Stem cells from adipose tissue improve the time of wound healing in rats.
abstract: To evaluate the Adipose Stem Cells (ACS) therapy efficacy on the time and quality of wound healing process in rats.
  Nine male Wistar rats were randomly distributed into three groups I) 7 days of healing; II) 14 days of healing; III) 21 days of healing. Four incisions were made on the dorsal surface of each rat and then treated with intralesional ACS, meloxicam, and no treatment and ACS+meloxicam. Macroscopic evaluation was measured by percentage of healing and histopathological by hematoxylin-eosin was performed.
  All groups have the wound reduced during the three weeks (p<0.001) and after 14 days of healing had greater reduction than others. Wounds treated with ASC had accelerated healing in relation to no treatment and only meloxicam (p<0.001), excepting the ASC+Meloxicam that was similar (p=0.13). There was no difference in histopathological analysis between lesions.
  Adipose stem cell have benefits in reducing time of healing of experimental model of wound in rats, observed 7 days of after application.
authors.affiliation: MD, Department of Surgery, Universidade Federal do Pará (UFPA), Belem-PA, Brazil. Technical procedures, acquisition and interpretation of data, manuscript writing.
authors.forename: Camila Melo
authors.initials: CM
authors.lastname: Ohashi
authors.affiliation: MD, Department of Surgery, Universidade Federal do Pará (UFPA), Belem-PA, Brazil. Technical procedures, acquisition and interpretation of data, manuscript writing.
authors.forename: Fabio Alves Morikawa
authors.initials: FA
authors.lastname: Caldeira
authors.affiliation: Graduate student, Department of Integrated Health, Universidade Estadual do Pará (UEPA), Belem-PA, Brazil. Technical procedures, manuscript preparation.
authors.forename: Denilson José Silva
authors.initials: DJ
authors.lastname: Feitosa-Junior
authors.affiliation: Graduate student, Department of Integrated Health, Universidade Estadual do Pará (UEPA), Belem-PA, Brazil. Technical procedures, manuscript preparation.
authors.forename: André Lopes
authors.initials: AL
authors.lastname: Valente
authors.affiliation: Biomedical scientist, Department of Biology, UFPA, Belem-PA, Brazil. Technical procedures.
authors.forename: Paulo Roberto Witter
authors.initials: PR
authors.lastname: Dutra
authors.affiliation: PhD, Associate Professor, Department of Biological Sciences, UFPA, Belem-PA, Brazil. Interpretation of data, critical revision.
authors.forename: Moysés Dos Santos
authors.initials: MD
authors.lastname: Miranda
authors.affiliation: PhD, Associate Professor, Department of Histology and Embriology, UFPA, Belem-PA, Brazil. Interpretation of data, critical revision.
authors.forename: Simone do Socorro Damasceno
authors.initials: SD
authors.lastname: Santos
authors.affiliation: PhD, Full Professor, Department of Integrated Health, UEPA, Belem-PA, Brazil. Technical procedures, interpretation of data, critical revision.
authors.forename: Marcus Vinicius Henriques
authors.initials: MV
authors.lastname: Brito
authors.affiliation: PhD, Associate Professor, Department of Biological Sciences, UFPA, Belem-PA, Brazil. Interpretation of data, critical revision.
authors.forename: Otávio Mitio
authors.initials: OM
authors.lastname: Ohashi
authors.affiliation: PhD, Associate Professor, Department of Surgery, UFPA, Belem-PA, Brazil. Scientific and intellectual content of the study, interpretation of data, critical revision.
authors.forename: Edson Yuzur
authors.initials: EY
authors.lastname: Yasojima
mesh_terms: D000273:Adipose Tissue / Q000166:cytology*; D000818:Animals; D000954:Antigens, Surface; D004195:Disease Models, Animal; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000502:physiology*; D016896:Treatment Outcome; D014945:Wound Healing / Q000502:physiology*; D014947:Wounds and Injuries / Q000628:therapy*
chemical_list: D000954:Antigens, Surface; C046045:Ran 2 protein, rat