title: Dibenzofurans and Pseudodepsidones from the Lichen Stereocaulon paschale Collected in Northern Quebec.
abstract: Chemical investigation of the methanol extract of the lichen Stereocaulon paschale collected in Nunavik, Canada, led to the isolation and identification of two new dibenzofurans (1 and 3) and 11 known lichen metabolites. The structures of the new compounds were established by analysis of 1D and 2D NMR spectroscopic and high-resolution mass spectrometric data. Herein, the first isolation of ascomatic acid dibenzofuran derivatives (1-3) from a whole lichen organism is reported. In addition, some of the isolated metabolites showed antibacterial activity against the oral pathogens Porphyromonas gingivalis and Streptococcus mutans.
authors.forename: Claudia
authors.initials: C
authors.lastname: Carpentier
authors.affiliation: School of Pharmaceutical Sciences, University of Geneva, University of Lausanne , Rue Michel-Servet, CH-1211 Geneva 4, Switzerland.
authors.forename: Emerson Ferreira
authors.identifier: 0000-0001-9567-1664
authors.initials: EF
authors.lastname: Queiroz
authors.affiliation: School of Pharmaceutical Sciences, University of Geneva, University of Lausanne , Rue Michel-Servet, CH-1211 Geneva 4, Switzerland.
authors.forename: Laurence
authors.initials: L
authors.lastname: Marcourt
authors.affiliation: School of Pharmaceutical Sciences, University of Geneva, University of Lausanne , Rue Michel-Servet, CH-1211 Geneva 4, Switzerland.
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Wolfender
authors.affiliation: Groupe de Recherche en Écologie Buccale, Faculté de Médecine Dentaire, Université Laval , 2420 Rue de la Terrasse, Québec G1V 0A6, Canada.
authors.forename: Jabrane
authors.initials: J
authors.lastname: Azelmat
authors.affiliation: Groupe de Recherche en Écologie Buccale, Faculté de Médecine Dentaire, Université Laval , 2420 Rue de la Terrasse, Québec G1V 0A6, Canada.
authors.forename: Daniel
authors.initials: D
authors.lastname: Grenier
authors.forename: Stéphane
authors.initials: S
authors.lastname: Boudreau
authors.forename: Normand
authors.identifier: 0000-0002-0429-9172
authors.initials: N
authors.lastname: Voyer
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002170:Canada; D000072318:Dibenzofurans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008011:Lichens / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D016966:Porphyromonas gingivalis / Q000187:drug effects*; D013295:Streptococcus mutans
chemical_list: D000900:Anti-Bacterial Agents; D000072318:Dibenzofurans