title: Orthodontic forces modulate insulin-like growth factor binding protein-5 changes in gingival crevicular fluid.
abstract: Orthodontic tooth movement results from the response of the periodontal tissue to orthodontic force, which leads to modeling and remodeling of the surrounding alveolar bone. The response is considered to occur through the activation of specific signaling pathways, many of which are known, all acting to ultimately result in tooth movement. Much is known about the actions of these two cells, and the signaling pathways that affect them, both in bone and orthodontic literature, however, to date, little work has been carried out to examine the effect of the insulin-like growth factor binding proteins (IGFBP) in orthodontics. Therefore, we investigated the presence of IGFBP-5 in the gingival crevicular fluid (GCF) of 6 healthy subjects, and assessed the effects of orthodontic treatment on the levels and molecular state of this protein.
authors.affiliation: Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari Aldo Moro, Bari, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Ballini
authors.affiliation: Ionian Department, University of Bari Aldo Moro, Taranto, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Santacroce
authors.affiliation: Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari Aldo Moro, Bari, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Cantore
authors.affiliation: Department of Periodontology and Oral Implantology, Pravara Institute of Medical Sciences, Loni, Maharashtra, India.
authors.forename: R
authors.initials: R
authors.lastname: Saini
authors.affiliation: Department of Oral Sciences, San Raffaele Research Institute, Vita e Salute University, Milan, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Mastrangelo
authors.affiliation: Department of Interdisciplinary Medicine, University of Bari Aldo Moro Bari, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Desiate
authors.affiliation: Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari Aldo Moro, Bari, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Scacco
mesh_terms: D000293:Adolescent; D016723:Bone Remodeling / Q000502:physiology*; D005260:Female; D005883:Gingival Crevicular Fluid / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D018975:Insulin-Like Growth Factor Binding Protein 5 / Q000032:analysis / Q000096:biosynthesis*; D008297:Male; D014087:Tooth Movement Techniques; D055815:Young Adult
chemical_list: D018975:Insulin-Like Growth Factor Binding Protein 5