title: Updating temporal expectancy of an aversive event engages striatal plasticity under amygdala control.
abstract: Pavlovian aversive conditioning requires learning of the association between a conditioned stimulus (CS) and an unconditioned, aversive stimulus (US) but also involves encoding the time interval between the two stimuli. The neurobiological bases of this time interval learning are unknown. Here, we show that in rats, the dorsal striatum and basal amygdala belong to a common functional network underlying temporal expectancy and learning of a CS-US interval. Importantly, changes in coherence between striatum and amygdala local field potentials (LFPs) were found to couple these structures during interval estimation within the lower range of the theta rhythm (3-6 Hz). Strikingly, we also show that a change to the CS-US time interval results in long-term changes in cortico-striatal synaptic efficacy under the control of the amygdala. Collectively, this study reveals physiological correlates of plasticity mechanisms of interval timing that take place in the striatum and are regulated by the amygdala.
authors.affiliation: Institut des Neurosciences Paris-Saclay (Neuro-PSI), Cognition and Behaviour Department, UMR 9197, Université Paris Sud, CNRS, Université Paris Saclay, Orsay F-91405, France.
authors.forename: Glenn
authors.initials: G
authors.lastname: Dallérac
authors.affiliation: Center for Neural Science, New York University, New York, New York 10003, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Graupner
authors.affiliation: Institut des Neurosciences Paris-Saclay (Neuro-PSI), Cognition and Behaviour Department, UMR 9197, Université Paris Sud, CNRS, Université Paris Saclay, Orsay F-91405, France.
authors.forename: Jeroen
authors.initials: J
authors.lastname: Knippenberg
authors.affiliation: Laboratory of Neuromodulation, Teaching and Research Institute, Hospital Sirio Libanes, Rua Professor Daher Cutait, 69, Sao Paulo 01308-060, Brazil.
authors.forename: Raquel Chacon Ruiz
authors.initials: RC
authors.lastname: Martinez
authors.affiliation: Institut des Neurosciences Paris-Saclay (Neuro-PSI), Cognition and Behaviour Department, UMR 9197, Université Paris Sud, CNRS, Université Paris Saclay, Orsay F-91405, France.
authors.forename: Tatiane Ferreira
authors.initials: TF
authors.lastname: Tavares
authors.affiliation: Institut des Neurosciences Paris-Saclay (Neuro-PSI), Cognition and Behaviour Department, UMR 9197, Université Paris Sud, CNRS, Université Paris Saclay, Orsay F-91405, France.
authors.forename: Lucille
authors.initials: L
authors.lastname: Tallot
authors.affiliation: Institut des Neurosciences Paris-Saclay (Neuro-PSI), Cognition and Behaviour Department, UMR 9197, Université Paris Sud, CNRS, Université Paris Saclay, Orsay F-91405, France.
authors.forename: Nicole
authors.initials: N
authors.lastname: El Massioui
authors.affiliation: Institut des Neurosciences Paris-Saclay (Neuro-PSI), Cognition and Behaviour Department, UMR 9197, Université Paris Sud, CNRS, Université Paris Saclay, Orsay F-91405, France.
authors.forename: Anna
authors.initials: A
authors.lastname: Verschueren
authors.affiliation: Institut des Neurosciences Paris-Saclay (Neuro-PSI), Cognition and Behaviour Department, UMR 9197, Université Paris Sud, CNRS, Université Paris Saclay, Orsay F-91405, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Höhn
authors.affiliation: Institut des Neurosciences Paris-Saclay (Neuro-PSI), Cognition and Behaviour Department, UMR 9197, Université Paris Sud, CNRS, Université Paris Saclay, Orsay F-91405, France.|École Normale Supérieure, Lyon F-69007, France.
authors.forename: Julie Boulanger
authors.identifier: 0000-0001-9213-1814
authors.initials: JB
authors.lastname: Bertolus
authors.affiliation: Center for Neural Science, New York University, New York, New York 10003, USA.
authors.forename: Alex
authors.initials: A
authors.lastname: Reyes
authors.affiliation: Center for Neural Science, New York University, New York, New York 10003, USA.|Nathan Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA.
authors.forename: Joseph E
authors.initials: JE
authors.lastname: LeDoux
authors.affiliation: Department of Psychology, Hunter College, New York, New York 10065, USA.
authors.forename: Glenn E
authors.initials: GE
authors.lastname: Schafe
authors.affiliation: Center for Neural Science, New York University, New York, New York 10003, USA.
authors.forename: Lorenzo
authors.identifier: 0000-0001-6766-9479
authors.initials: L
authors.lastname: Diaz-Mataix
authors.affiliation: Institut des Neurosciences Paris-Saclay (Neuro-PSI), Cognition and Behaviour Department, UMR 9197, Université Paris Sud, CNRS, Université Paris Saclay, Orsay F-91405, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Doyère
mesh_terms: D000679:Amygdala / Q000033:anatomy & histology / Q000502:physiology*; D000818:Animals; D003214:Conditioning, Classical / Q000502:physiology*; D003342:Corpus Striatum / Q000033:anatomy & histology / Q000502:physiology*; D004567:Electrodes, Implanted; D005239:Fear / Q000502:physiology; D008297:Male; D008568:Memory / Q000502:physiology; D009473:Neuronal Plasticity / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013826:Theta Rhythm / Q000502:physiology; D013998:Time Perception / Q000502:physiology*