title: Non-directed aromatic C-H amination: catalytic and mechanistic studies enabled by Pd catalyst and reagent design.
abstract: This manuscript describes the systematic development of pyridine-type ligands, which promote the Pd catalyzed, non-directed amination of benzene in combination with novel, hydroxylamine-based electrophilic amination reagents. DFT calculations and mechanistic experiments provide insights into the factors influencing the arene C-H amination protocol.
authors.affiliation: Department of Chemistry and Biochemistry, Worcester Polytechnic Institute, 100 Institute Road, Worcester, MA, USA.
authors.forename: H M D
authors.initials: HM
authors.lastname: Bandara
authors.affiliation: Department of Chemistry and Biochemistry, Worcester Polytechnic Institute, 100 Institute Road, Worcester, MA, USA.
authors.forename: D
authors.initials: D
authors.lastname: Jin
authors.affiliation: Department of Chemistry and Biochemistry, Worcester Polytechnic Institute, 100 Institute Road, Worcester, MA, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Mantell
authors.affiliation: Department of Chemistry and Biochemistry, Worcester Polytechnic Institute, 100 Institute Road, Worcester, MA, USA.
authors.forename: K D
authors.initials: KD
authors.lastname: Field
authors.affiliation: Department of Chemistry and Biochemistry, Worcester Polytechnic Institute, 100 Institute Road, Worcester, MA, USA.
authors.forename: A
authors.initials: A
authors.lastname: Wang
authors.affiliation: Department of Chemistry and Biochemistry, Worcester Polytechnic Institute, 100 Institute Road, Worcester, MA, USA.
authors.forename: R P
authors.initials: RP
authors.lastname: Narayanan
authors.affiliation: Department of Chemical Engineering, Worcester Polytechnic Institute, 100 Institute Road, Worcester, MA, USA.
authors.forename: N A
authors.initials: NA
authors.lastname: Deskins
authors.affiliation: Department of Chemistry and Biochemistry, Worcester Polytechnic Institute, 100 Institute Road, Worcester, MA, USA.
authors.forename: M H
authors.initials: MH
authors.lastname: Emmert