title: Retrospective Neuropsychological Profile of Patients With Parkinson Disease Prior to Developing Visual Hallucinations.
abstract: Visual hallucinations (VH) are a common feature of Parkinson disease (PD); however, the cognitive profile preceding the onset of VH has not yet been established. The present study investigated longitudinal neuropsychological performance of patients with PD who developed VH during follow-up compared to a group who did not develop VH. The patient groups were matched for demographic and disease severity variables at their baseline assessments. Patients who developed VH displayed impaired performance at baseline on measures of psychomotor speed, executive functioning, reaction time, and attention compared to patients who did not develop VH. These results demonstrate a profile of cognitive deficits specific to patients with PD at risk of developing VH and implicate attentional dysfunction in the early pathogenesis of VH.
authors.affiliation: 1 Parkinson's Disease Research Clinic, Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia.
authors.forename: Alana J
authors.initials: AJ
authors.lastname: Muller
authors.affiliation: 1 Parkinson's Disease Research Clinic, Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia.|2 Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom.|3 Department of Psychology, University of Cambridge, Cambridge, United Kingdom.
authors.forename: Claire
authors.initials: C
authors.lastname: O'Callaghan
authors.affiliation: 1 Parkinson's Disease Research Clinic, Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia.
authors.forename: Courtney C
authors.initials: CC
authors.lastname: Walton
authors.affiliation: 4 School of Psychology, Stanford University, Stanford, CA, USA.|5 Neuroscience Research Australia, University of New South Wales, Kensington, New South Wales, Australia.
authors.forename: James M
authors.initials: JM
authors.lastname: Shine
authors.affiliation: 1 Parkinson's Disease Research Clinic, Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia.
authors.forename: Simon J G
authors.initials: SJ
authors.lastname: Lewis
mesh_terms: D000368:Aged; D001288:Attention / Q000502:physiology; D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000209:etiology / Q000523:psychology*; D056344:Executive Function; D005260:Female; D006212:Hallucinations / Q000175:diagnosis / Q000523:psychology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data*; D009484:Neuropsychology; D010300:Parkinson Disease / Q000150:complications* / Q000523:psychology; D012189:Retrospective Studies
keywords: Parkinson disease; hallucinations; neuropsychology