title: Multidisciplinary Approach to Management of Temporal Bone Giant Cell Tumor.
abstract: BackgroundGiant cell tumors (GCTs) are rare osseous tumors that rarely appear in the skull.MethodsWe review the clinical course of a 28-year-old previously healthy woman with a complicated GCT.ResultsThe reviewed patient presented with a middle cranial fossa tumor acutely complicated by reactive mastoiditis. Left tympanomastoidectomy was performed for drainage of the mastoiditis and for biopsies of the tumor. Due to the challenging tumor location, the patient was treated with denosumab, a fully humanized monoclonal antibody against receptor activator of nuclear factor kappa-B ligand, for 7 months, which resulted in significant preoperative tumor shrinkage. Extensive temporal craniotomy and resection of the tumor followed utilizing a temporomandibular joint total endoprosthesis for reconstruction. A recurrence of the tumor was detected on computed tomography at 19 months after surgery and treated with transtemporal tumor resection, parotidectomy, and mandible re-reconstruction.ConclusionA multidisciplinary approach resulted in a good functional result and, finally, an eradication of the challengingly located middle cranial fossa tumor.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
authors.forename: Taija K
authors.initials: TK
authors.lastname: Nicoli
authors.affiliation: Department of Radiology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
authors.forename: Riste
authors.initials: R
authors.lastname: Saat
authors.affiliation: Department of Maxillofacial Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
authors.forename: Risto
authors.initials: R
authors.lastname: Kontio
authors.affiliation: Department of Neurosurgery, University of Helsinki and Helsinki University Hospital, Helsinki Finland.
authors.forename: Anna
authors.initials: A
authors.lastname: Piippo
authors.affiliation: Cancer Centre, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
authors.forename: Maija
authors.initials: M
authors.lastname: Tarkkanen
authors.affiliation: Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
authors.forename: Jussi
authors.initials: J
authors.lastname: Tarkkanen
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
authors.forename: Jussi
authors.initials: J
authors.lastname: Jero
keywords: giant cell tumor; management; multidisciplinary; surgery; temporal bone