title: Sources of variability in the measurement of perfusion defect size using commercially available software programs: Are there gender differences?
abstract: We recently showed that Quantitative Perfusion SPECT (QPS), Emory Cardiac Toolbox (ECTb) and 4-Dimension-Myocardial SPECT (4DM) yielded discordant results in the assessment of perfusion defect size (PDS) in patients with known or suspected coronary artery disease. In this report, we examined the sources of variability in the measurement of PDS using ECTb (VarECTb), 4DM (Var4DM) and QPS (VarQPS) and found that gender is a source of variability in the assessment of PDS. In 120 patients, VarECTbwas lower in men, compared with women, whereas Var4DMand VarQPSwere similar between both genders. Among men, VarECTbwas lowest, compared with VarQPSand Var4DM, whereas, VarECTb, VarQPS, and Var4DMwere not different among women. Future studies should account for gender differences when comparing the 3 software programs.
authors.affiliation: Division of Cardiovascular Disease, University of Alabama at Birmingham, Lyons Harrison Research Building 306, 1720 2nd AV S, Birmingham, AL, 35294, USA. sameer_ather@yahoo.com.|Section of Cardiology, Birmingham Veterans Affairs Medical Center, Birmingham, AL, USA. sameer_ather@yahoo.com.
authors.forename: Sameer
authors.initials: S
authors.lastname: Ather
authors.affiliation: Division of Cardiovascular Disease, University of Alabama at Birmingham, Lyons Harrison Research Building 306, 1720 2nd AV S, Birmingham, AL, 35294, USA.
authors.forename: Ami E
authors.initials: AE
authors.lastname: Iskandrian
authors.affiliation: Division of Cardiovascular Disease, University of Alabama at Birmingham, Lyons Harrison Research Building 306, 1720 2nd AV S, Birmingham, AL, 35294, USA.|Section of Cardiology, Birmingham Veterans Affairs Medical Center, Birmingham, AL, USA.
authors.forename: Fadi G
authors.initials: FG
authors.lastname: Hage
mesh_terms: D000465:Algorithms; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000473:pathology*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods; D008297:Male; D008875:Middle Aged; D055414:Myocardial Perfusion Imaging / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012727:Sex Characteristics; D012984:Software; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
keywords: Myocardial perfusion imaging; perfusion defect size; single-photon emission computed tomography