title: Lkb1 regulation of skeletal muscle development, metabolism and muscle progenitor cell homeostasis.
abstract: Liver kinase B1 (Lkb1), also named as Serine/Threonine protein kinase 11 (STK11), is a serine/threonine kinase that plays crucial roles in various cellular processes including cell survival, cell division, cellular polarity, cell growth, cell differentiation, and cell metabolism. In metabolic tissues, Lkb1 regulates glucose homeostasis and energy metabolism through phosphorylating and activating the AMPK subfamily proteins. In skeletal muscle, Lkb1 affects muscle development and postnatal growth, lipid and fatty acid oxidation, glucose metabolism, and insulin sensitivity. Recently, the regulatory roles of Lkb1 in regulating division, self-renew, proliferation, and differentiation of skeletal muscle progenitor cells have been reported. In this review, we discuss the roles of Lkb1 in regulating skeletal muscle progenitor cell homeostasis and skeletal muscle development and metabolism.
authors.affiliation: College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang, P. R. China.|The Key Laboratory of Molecular Animal Nutrition, Ministry of Education, Zhejiang University, Hangzhou, Zhejiang, P. R. China.|Zhejiang Provincial Laboratory of Feed and Animal Nutrition, Zhejiang University, Hangzhou, Zhejiang, P. R. China.
authors.forename: Tizhong
authors.identifier: http://orcid.org/0000-0002-4738-414X
authors.initials: T
authors.lastname: Shan
authors.affiliation: College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang, P. R. China.|The Key Laboratory of Molecular Animal Nutrition, Ministry of Education, Zhejiang University, Hangzhou, Zhejiang, P. R. China.|Zhejiang Provincial Laboratory of Feed and Animal Nutrition, Zhejiang University, Hangzhou, Zhejiang, P. R. China.
authors.forename: Ziye
authors.initials: Z
authors.lastname: Xu
authors.affiliation: College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang, P. R. China.|The Key Laboratory of Molecular Animal Nutrition, Ministry of Education, Zhejiang University, Hangzhou, Zhejiang, P. R. China.|Zhejiang Provincial Laboratory of Feed and Animal Nutrition, Zhejiang University, Hangzhou, Zhejiang, P. R. China.
authors.forename: Jiaqi
authors.initials: J
authors.lastname: Liu
authors.affiliation: College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang, P. R. China.|The Key Laboratory of Molecular Animal Nutrition, Ministry of Education, Zhejiang University, Hangzhou, Zhejiang, P. R. China.|Zhejiang Provincial Laboratory of Feed and Animal Nutrition, Zhejiang University, Hangzhou, Zhejiang, P. R. China.
authors.forename: Weiche
authors.initials: W
authors.lastname: Wu
authors.affiliation: College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang, P. R. China.|The Key Laboratory of Molecular Animal Nutrition, Ministry of Education, Zhejiang University, Hangzhou, Zhejiang, P. R. China.|Zhejiang Provincial Laboratory of Feed and Animal Nutrition, Zhejiang University, Hangzhou, Zhejiang, P. R. China.
authors.forename: Yizhen
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000091162:AMP-Activated Protein Kinase Kinases; D000818:Animals; D002454:Cell Differentiation; D049109:Cell Proliferation; D004734:Energy Metabolism; D006706:Homeostasis; D006801:Humans; D024510:Muscle Development; D018482:Muscle, Skeletal / Q000201:enzymology* / Q000254:growth & development; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D015398:Signal Transduction; D013234:Stem Cells / Q000201:enzymology*
chemical_list: D017346:Protein Serine-Threonine Kinases; C109790:STK11 protein, human; D000091162:AMP-Activated Protein Kinase Kinases
keywords: Lkb1; STK11; muscle development; myoblast; satellite cell