title: Multiple Oral Mucosal Hamartomas in a 34-Year Old Female.
abstract: A case of Cowden syndrome (CS) is described in a 34-year-old African American female who reported a history of breast and thyroid malignancies. Clinical examination demonstrated multiple soft, white-pink papules across multiple mucosal surfaces of the oral cavity. Microscopy of the lesions revealed hyperkeratotic surface squamous epithelium with papillomatosis and acanthosis along with elongated rete processes. A genomic polymerase chain reaction direct sequencing using the patient's blood was positive for mutations of the PTEN gene typical of CS.
authors.affiliation: Division of Oral and Maxillofacial Surgery, Western University of Health Sciences College of Dental Medicine, 795 E. Second St., 3rd Floor, Pomona, CA, 91766, USA. jelo@WesternU.edu.|Department of Oral and Maxillofacial Surgery, Loma Linda University Medical Center, Loma Linda, CA, USA. jelo@WesternU.edu.
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Elo
authors.affiliation: Western University of Health Sciences College of Dental Medicine, Pomona, CA, USA.
authors.forename: Ho-Hyun
authors.initials: HH
authors.lastname: Sun
authors.affiliation: Division of Oral Medicine, Western University of Health Sciences College of Dental Medicine, Pomona, CA, USA.
authors.forename: Joel M
authors.initials: JM
authors.lastname: Laudenbach
authors.affiliation: Western University of Health Sciences College of Dental Medicine, Pomona, CA, USA.
authors.forename: Hardev M
authors.initials: HM
authors.lastname: Singh
mesh_terms: D000328:Adult; D005260:Female; D006223:Hamartoma Syndrome, Multiple / Q000473:pathology*; D006801:Humans; D009062:Mouth Neoplasms / Q000473:pathology*
keywords: Cowden syndrome; Oral hamartomas; Oral papules