title: [Relationship between metastatic lymph node and prognosis of esophageal cancer patients treated with following radical esophagectomy].
abstract: Objective:To investigate the number of metastatic lymph nodes (pN) and the metastatic lymph node ratio (LNR) on the post-surgical prognosis of patients with esophageal cancer (EC).Methods:A retrospective analysis of 573 inpatients diagnosed as esophageal carcinomas from March 2008 to June 2012 was carried out.All pathologic specimen were reviewed by pathologists from Henan Tumor Hospital.The Kaplan-Meier method was used to calculate survival rates, and survival curves were compared with the Log-rank test.The Cox model was employed for multivariate analyses of factors.The association of pN and LNR with prognosis of esophageal cancer was examined by the area under the ROC curve(AUC).Results:The 1-, 3- and 5-year OS rates were 72.5%, 46.1% and 32.3%, respectively.Univariate analysis showed that tumor location(P=0.020), tumor length(P=0.009), pT stage(P=0.011), pN stage(P<0.01), and the LNR(P<0.01) were prognostic factors for OS.Multivariate analysis indicated that pT stage(P=0.047), pN stage(P=0.018) and LNR(P=0.011) were significant and independent risk factors for poor OS.ROC analysis indicated that LNR (AUC=0.680) had better predictive value than pN (AUC=0.579).Conclusion:The integrated use of LNR and pN may be suitable for evaluation of prognosis in patients with EC and positive nodal metastasis after curative resection.
authors.affiliation: Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou 450000, China.
authors.forename: W Y
authors.initials: WY
authors.lastname: Deng
authors.forename: C
authors.initials: C
authors.lastname: Wei
authors.forename: N
authors.initials: N
authors.lastname: Li
authors.forename: Y P
authors.initials: YP
authors.lastname: Zhang
authors.forename: W
authors.initials: W
authors.lastname: Shen
authors.forename: C
authors.initials: C
authors.lastname: Zhang
authors.forename: S X
authors.initials: SX
authors.lastname: Luo
mesh_terms: D004938:Esophageal Neoplasms; D016629:Esophagectomy; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes; D008207:Lymphatic Metastasis; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011379:Prognosis; D012372:ROC Curve; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate