title: Raman Spectroscopy of Pharmaceutical Cocrystals in Nanosized Pores of Mesoporous Silica.
abstract: The Raman spectroscopy of pharmaceutical cocrystals based on caffeine and oxalic acid in nanosized pores of mesoporous silica has been demonstrated at various molar amounts. The Raman peak shifts of caffeine molecules express the existence of pharmaceutical cocrystals in mesoporous silica. The molar amount dependence of the peak shifts describes that caffeine and oxalic acid cocrystallized on the surface of the nanosized pores and piled up layer by layer. This is the first report that shows the Raman spectroscopy is a powerful tool to observe the synthesis of pharmaceutical cocrystals incorporated in the nanosized pores of mesoporous silica. The results indicate a way to control the size of cocrystals on a nanometer scale, which will provide higher bioavailability of pharmaceuticals.
authors.affiliation: NTT Device Technology Laboratories, NTT Corporation.
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Ohta
authors.forename: Yuko
authors.initials: Y
authors.lastname: Ueno
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Ajito
mesh_terms: D002110:Caffeine / Q000737:chemistry*; D002725:Chloroform / Q000737:chemistry; D003460:Crystallization; D000432:Methanol / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry*; D019815:Oxalic Acid / Q000737:chemistry*; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*; D012995:Solubility; D013059:Spectrum Analysis, Raman; D013696:Temperature
chemical_list: D002110:Caffeine; D012822:Silicon Dioxide; D002725:Chloroform; D019815:Oxalic Acid; D000432:Methanol