title: Exploring Polyubiquitin as a Flexible Multiple-Ligand Binding Platform.
abstract: Linear (head-to-tail linked) polyubiquitin chains play a key role in the regulation of NF-κB signaling. In this issue of Structure, Lin et al. (2017) shed light on how linear tri-ubiquitin binds to ABIN2, a molecule that shares ubiquitin-binding properties of NEMO, the key activator of NF-κB.
authors.affiliation: Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA. Electronic address: fushman@umd.edu.
authors.forename: David
authors.initials: D
authors.lastname: Fushman
mesh_terms: D051550:I-kappa B Kinase / Q000737:chemistry*; D016328:NF-kappa B; D025821:Polyubiquitin; D011485:Protein Binding; D025801:Ubiquitin / Q000737:chemistry
chemical_list: D016328:NF-kappa B; D025801:Ubiquitin; D025821:Polyubiquitin; D051550:I-kappa B Kinase