title: Low-Grade Metabolically-Induced Inflammation Mediators Interleukin-6, Adiponectin, and TNF-α Serum Levels in Obese Pregnant Patients in the Perinatal Period.
abstract: BACKGROUND Obesity is a major clinical problem. The number of obese pregnant women is rising rapidly. The consequences of obesity are significant and affect every aspect of perinatal care for both the mother and the developing fetus. Adipose tissue may be responsible for chronic subclinical inflammation in obesity, being a source of inflammatory mediators. The study was designed to evaluate the analysis of the serum concentration of inflammatory mediators, including interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), and adiponectin, in obese pregnant women at full-term pregnancies. MATERIAL AND METHODS The study included 40 women with body mass index (BMI) less than 30 and 24 pregnant women with BMI equal to or greater than 30, admitted to the Perinatology and Obstetrics Department of the University Hospital in Cracow in the first stage of labor. Blood samples were taken from patients to detect the serum concentration of cytokines. Ultrasound was used to evaluate the development of the fetus, including estimated fetal weight, Doppler flows, and the amount of amniotic fluid. We also included the history of chronic diseases and other complications of the pregnancy. A p-value <0.05 was considered significant. RESULTS The level of adiponectin in obese patients as compared to controls was significantly lower. There was no statistically significant difference in either group when TNF-α and IL-6 were measured. The results of the survey are consistent with previous reports. CONCLUSIONS The exact role of inflammation in pregnancy is not well understood. Determining the exact functions of the different cytokines in physiological pregnancy and pregnancy complicated by obesity requires further study.
authors.affiliation: Clinical Department of Obstetrics and Perinatology, University Hospital, Cracow, Poland.
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Zembala-Szczerba
authors.affiliation: Clinical Department of Obstetrics and Perinatology, University Hospital, Cracow, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Jaworowski
authors.affiliation: Clinical Department of Obstetrics and Perinatology, University Hospital, Cracow, Poland.
authors.forename: Hubert
authors.initials: H
authors.lastname: Huras
authors.affiliation: Clinical Department of Obstetrics and Perinatology, University Hospital, Cracow, Poland.
authors.forename: Dorota
authors.initials: D
authors.lastname: Babczyk
authors.affiliation: Clinical Department of Obstetrics and Perinatology, University Hospital, Cracow, Poland.
authors.forename: Robert
authors.initials: R
authors.lastname: Jach
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000273:Adipose Tissue / Q000378:metabolism; D000328:Adult; D016207:Cytokines / Q000097:blood; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood; D018836:Inflammation Mediators / Q000097:blood; D015850:Interleukin-6 / Q000097:blood*; D008875:Middle Aged; D009765:Obesity / Q000097:blood*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D052242:Adiponectin; D016207:Cytokines; C508600:IL6 protein, human; D018836:Inflammation Mediators; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha