title: Oncocytic carcinoma of the salivary gland in a dog.
abstract: A 3-y-old male miniature Dachshund was presented with an ~0.8 cm diameter mass in the right mandibular region. Fourteen months later, the mass was 5 × 4 × 3 cm. Grossly, the mass was encapsulated and was homogeneously gray-white on cut surface. Microscopically, the mass was composed of large, round to polygonal tumor cells that were arranged in solid nests and cords separated by a fibrovascular stroma. Tumor cells had large, round, hypochromatic nuclei containing large prominent nucleoli and abundant eosinophilic cytoplasm containing dark blue granules visible with phosphotungstic acid-hematoxylin stain. Metastasis was observed in the mandibular lymph node. Immunohistochemically, tumor cells were positive for CK AE1/AE3, low-molecular-weight CK (CAM5.2), E-cadherin, mitochondria ATPase beta subunit, and S100, but were negative for vimentin, carcinoembryonic antigen, p63, CK14, CD10, and chromogranin A. Ultrastructurally, tumor cells contained numerous mitochondria. Therefore, the tumor was diagnosed as an oncocytic carcinoma of the mandibular gland.
authors.affiliation: Departments of Veterinary Pathology (Nakahira, Michishita, Kato, Okuno, Takahashi), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.|Comparative Cellular Biology (Hatakeyama), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.|Applied Science (Yoshimura), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.|Veterinary Nursing (Azakami), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.|Basic Science (Ochiai), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.|Veterinary Clinical Pathology (Bonkobara), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.
authors.forename: Rei
authors.initials: R
authors.lastname: Nakahira
authors.affiliation: Departments of Veterinary Pathology (Nakahira, Michishita, Kato, Okuno, Takahashi), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.|Comparative Cellular Biology (Hatakeyama), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.|Applied Science (Yoshimura), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.|Veterinary Nursing (Azakami), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.|Basic Science (Ochiai), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.|Veterinary Clinical Pathology (Bonkobara), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Michishita
authors.affiliation: Departments of Veterinary Pathology (Nakahira, Michishita, Kato, Okuno, Takahashi), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.|Comparative Cellular Biology (Hatakeyama), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.|Applied Science (Yoshimura), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.|Veterinary Nursing (Azakami), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.|Basic Science (Ochiai), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.|Veterinary Clinical Pathology (Bonkobara), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.
authors.forename: Misaki
authors.initials: M
authors.lastname: Kato
authors.affiliation: Departments of Veterinary Pathology (Nakahira, Michishita, Kato, Okuno, Takahashi), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.|Comparative Cellular Biology (Hatakeyama), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.|Applied Science (Yoshimura), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.|Veterinary Nursing (Azakami), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.|Basic Science (Ochiai), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.|Veterinary Clinical Pathology (Bonkobara), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Okuno
authors.affiliation: Departments of Veterinary Pathology (Nakahira, Michishita, Kato, Okuno, Takahashi), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.|Comparative Cellular Biology (Hatakeyama), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.|Applied Science (Yoshimura), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.|Veterinary Nursing (Azakami), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.|Basic Science (Ochiai), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.|Veterinary Clinical Pathology (Bonkobara), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Hatakeyama
authors.affiliation: Departments of Veterinary Pathology (Nakahira, Michishita, Kato, Okuno, Takahashi), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.|Comparative Cellular Biology (Hatakeyama), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.|Applied Science (Yoshimura), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.|Veterinary Nursing (Azakami), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.|Basic Science (Ochiai), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.|Veterinary Clinical Pathology (Bonkobara), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Yoshimura
authors.affiliation: Departments of Veterinary Pathology (Nakahira, Michishita, Kato, Okuno, Takahashi), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.|Comparative Cellular Biology (Hatakeyama), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.|Applied Science (Yoshimura), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.|Veterinary Nursing (Azakami), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.|Basic Science (Ochiai), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.|Veterinary Clinical Pathology (Bonkobara), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.
authors.forename: Daigo
authors.initials: D
authors.lastname: Azakami
authors.affiliation: Departments of Veterinary Pathology (Nakahira, Michishita, Kato, Okuno, Takahashi), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.|Comparative Cellular Biology (Hatakeyama), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.|Applied Science (Yoshimura), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.|Veterinary Nursing (Azakami), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.|Basic Science (Ochiai), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.|Veterinary Clinical Pathology (Bonkobara), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Ochiai
authors.affiliation: Departments of Veterinary Pathology (Nakahira, Michishita, Kato, Okuno, Takahashi), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.|Comparative Cellular Biology (Hatakeyama), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.|Applied Science (Yoshimura), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.|Veterinary Nursing (Azakami), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.|Basic Science (Ochiai), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.|Veterinary Clinical Pathology (Bonkobara), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Bonkobara
authors.affiliation: Departments of Veterinary Pathology (Nakahira, Michishita, Kato, Okuno, Takahashi), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.|Comparative Cellular Biology (Hatakeyama), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.|Applied Science (Yoshimura), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.|Veterinary Nursing (Azakami), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.|Basic Science (Ochiai), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.|Veterinary Clinical Pathology (Bonkobara), School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.
authors.forename: Kimimasa
authors.initials: K
authors.lastname: Takahashi
mesh_terms: D018249:Adenoma, Oxyphilic / Q000175:diagnosis / Q000662:veterinary*; D000818:Animals; D002467:Cell Nucleus / Q000473:pathology; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000175:diagnosis* / Q000473:pathology; D004285:Dogs; D007150:Immunohistochemistry / Q000662:veterinary; D008297:Male; D012468:Salivary Gland Neoplasms / Q000175:diagnosis / Q000662:veterinary*
keywords: Canine; metastasis; oncocytic carcinoma; salivary gland