title: Self-Assembly Assisted Fabrication of Dextran-Based Nanohydrogels with Reduction-Cleavable Junctions for Applications as Efficient Drug Delivery Systems.
abstract: In order to overcome the key challenge in improving both fabrication efficiency and their drug delivery capability of anti-cancer drug delivery systems (ACDDS), here polyacrylic acid (PAA) grafted dextran (Dex) nanohydrogels (NGs) with covalent crosslinked structure bearing redox sensitive disulfide crosslinking junctions (Dex-SS-PAA) were synthesized efficiently through a one-step self-assembly assisted methodology (SAA). The Dex-SS-PAA were subsequently conjugated with doxorubicin through an acid-labile hydrazone bond (Dex-SS-PAA-DOX). The in vitro drug release behavior, anti-cancer effects in vivo, and biosafety of the as-prepared acid- and redox-dual responsive biodegradable NGs were systematically investigated. The results revealed that the Dex-SS-PAA-DOX exhibited pH- and redox-controlled drug release, greatly reduced the toxicity of free DOX, while exhibiting a strong ability to inhibit the growth of MDA-MB-231 tumors. Our study demonstrated that the Dex-SS-PAA-DOX NGs are very promising candidates as ACDDS for anti-cancer therapeutics.
authors.affiliation: The State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240 (P. R. China).
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Plastic and Reconstructive Surgery, Shanghai ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Tissue Engineering, National Tissue Engineering Center of China, Shanghai 200011 (P. R. China).
authors.forename: Tingting
authors.initials: T
authors.lastname: Dai
authors.affiliation: The State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240 (P. R. China).
authors.forename: Shuyan
authors.initials: S
authors.lastname: Zhou
authors.affiliation: The State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240 (P. R. China).
authors.forename: Xiaoxiao
authors.initials: X
authors.lastname: Huang
authors.affiliation: The State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240 (P. R. China).
authors.forename: Songying
authors.initials: S
authors.lastname: Li
authors.affiliation: The State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240 (P. R. China).
authors.forename: Kang
authors.initials: K
authors.lastname: Sun
authors.affiliation: Department of Plastic and Reconstructive Surgery, Shanghai ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Tissue Engineering, National Tissue Engineering Center of China, Shanghai 200011 (P. R. China).
authors.forename: Guangdong
authors.initials: G
authors.lastname: Zhou
authors.affiliation: The State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240 (P. R. China).
authors.forename: Hongjing
authors.initials: H
authors.lastname: Dou
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003911:Dextrans / Q000737:chemistry*; D004317:Doxorubicin / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D000067493:Dynamic Light Scattering; D006801:Humans; D006835:Hydrazones / Q000737:chemistry; D020100:Hydrogels / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D051379:Mice; D008819:Mice, Nude; D046529:Microscopy, Electron, Transmission; D049329:Nanostructures / Q000737:chemistry; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology; D010084:Oxidation-Reduction; D010316:Particle Size
chemical_list: D000970:Antineoplastic Agents; D003911:Dextrans; D004337:Drug Carriers; D006835:Hydrazones; D020100:Hydrogels; D004317:Doxorubicin