title: A New Development in Trypanosoma cruzi Detection.
abstract: Chagas disease is caused by the parasiteTrypanosoma cruziand is an important cause of morbidity and mortality in areas of Latin America where Chagas disease is endemic and among infected individuals who have migrated to nonendemic areas of North America and Europe. There are many diagnostic tests that are employed in the serological diagnosis of this infection. In this issue of theJournal of Clinical Microbiology, Bautista-López et al. provide characterization of excretory vesicles (EVs) from Vero cells infected withT. cruziand provide data on the EVs produced by trypomastigotes and amastigotes (N. L. Bautista-López et al., J Clin Microbiol 55:744-758, 2017, https://doi.org/10.1128/JCM.01649-16). Their proteomic study defines potential targets to evaluate for improved diagnostic tests, effects on host cell biology that contribute to the pathogenesis of infection, and vaccine candidates. If any of the EV-associated proteins identified were to be correlated to cure of infection, this would be a major advance.
authors.affiliation: Department of Pathology, Division of Tropical Medicine and Parasitology, and Department of Medicine, Division of Infectious Disease, Albert Einstein College of Medicine, Bronx, New York, USA herbert.tanowitz@einstein.yu.edu.
authors.forename: Herbert B
authors.initials: HB
authors.lastname: Tanowitz
authors.affiliation: Department of Pathology, Division of Tropical Medicine and Parasitology, and Department of Medicine, Division of Infectious Disease, Albert Einstein College of Medicine, Bronx, New York, USA.
authors.forename: Louis M
authors.initials: LM
authors.lastname: Weiss
mesh_terms: D000818:Animals; D014355:Chagas Disease; D002522:Chlorocebus aethiops; D005060:Europe; D006801:Humans; D007843:Latin America; D009656:North America; D040901:Proteomics; D014349:Trypanosoma cruzi / Q000276:immunology*; D014709:Vero Cells