title: In vitro effectiveness ofCurcuma longaandZingiber officinaleextracts onEchinococcusprotoscoleces.
abstract: Hydatid disease is an important economic and human public health problem with a wide geographical distribution. Surgical excision remains the primary treatment and the only hope for complete cure of hydatosis. The most important complications arising from surgical excision, however, is recurrence, which is due to dissemination of protoscolices during the surgery. Pre-surgical inactivation of the contents of the hydatid cyst by injection of scolicidal agent into the cyst has been used as adjunct to surgery in order to overcome the risk of recurrence. In the present study, ethanolic extracts of turmeric (Curcuma longa) and ginger (Zingiber officinale) were tested as scolicidal agent forEchinococcusprotoscoleces. Protoscoleces were collected aseptically from sheep livers containing hydatid cysts. Three concentrations (10, 30 and 50 mg/ml) of each extract were investigated and viability of the protoscoleces was tested by 0.1% eosin staining. Ginger extract showed the strongest scolicidal effect (100%) after 20 min at a concentration of 30 mg/ml and 10 min at 50 mg/ml.The maximum scolicidal effect of turmeric was 93.2% after 30 min at a concentration of 50 mg/ml. It is concluded that turmeric and ginger extracts have high scolicidal activity and could be used as effective scolicidal agents againstEchinococcusprotoscoleces.
authors.affiliation: Zoology Department, College of Science, King Saud University, Riyadh, Saudi Arabia; Department of Medical Laboratory, College of Applied Medical Sciences, Majmaah University, Saudi Arabia.
authors.forename: Esam
authors.initials: E
authors.lastname: Almalki
authors.affiliation: Zoology Department, College of Science, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Esam M
authors.initials: EM
authors.lastname: Al-Shaebi
authors.affiliation: Zoology Department, College of Science, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Saleh
authors.initials: S
authors.lastname: Al-Quarishy
authors.affiliation: Clinical Division of Fish Medicine, University of Veterinary Medicine, Vienna, Austria.
authors.forename: Mansour
authors.initials: M
authors.lastname: El-Matbouli
authors.affiliation: Zoology Department, College of Science, King Saud University, Riyadh, Saudi Arabia; Zoology Department, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt.
authors.forename: Abdel-Azeem S
authors.initials: AS
authors.lastname: Abdel-Baki
keywords: Ethanolic extract; Ginger; Hydatid cyst; Scolicidal; Turmeric