title: Nucleic acid components and their analogs: Design and synthesis of novel cytosine thioglycoside analogs.
abstract: The synthesis of a new category of novel cytosine 4-thioglycoside analogs has been first accomplished. The main step of this strategy is the synthesis of sodium pyrimidine-4-thiolate through the condensation of 2-cyano-N-arylacetamides with sodium cyanocarbonimidodithioate, followed by coupling with α-bromo-sugars to afford the corresponding cytosine 4-thioglycoside analogs. The free thioglycosides were also prepared. Subsequent studies on the application of this strategy for the preparation of other potent pyrimidine thioglycosides are reported.
authors.affiliation: a Chemistry Department , Faculty of Science, Helwan University , Helwan, Cairo , Egypt.
authors.forename: Galal H
authors.initials: GH
authors.lastname: Elgemeie
authors.affiliation: a Chemistry Department , Faculty of Science, Helwan University , Helwan, Cairo , Egypt.
authors.forename: Ali M
authors.initials: AM
authors.lastname: Salah
authors.affiliation: a Chemistry Department , Faculty of Science, Helwan University , Helwan, Cairo , Egypt.|c Chemistry Department , Faculty of Science, Taibah University , Saudi Arabia.
authors.forename: Nermeen S
authors.initials: NS
authors.lastname: Abbas
authors.affiliation: b Photochemistry Department , National Research Center , Dokki, Cairo , Egypt.
authors.forename: Hoda A
authors.initials: HA
authors.lastname: Hussein
authors.affiliation: b Photochemistry Department , National Research Center , Dokki, Cairo , Egypt.
authors.forename: Reham A
authors.initials: RA
authors.lastname: Mohamed
mesh_terms: D060326:Chemistry Techniques, Synthetic; D003596:Cytosine / Q000737:chemistry*; D015195:Drug Design; D015394:Molecular Structure; D013865:Thioglycosides / Q000138:chemical synthesis*
chemical_list: D013865:Thioglycosides; D003596:Cytosine
keywords: 2-cyano-N-arylacetamides; Pyrimidine thioglycosides; antimetabolites; sodium cyanocarbonimidodithioate