title: The prevalence of celiac disease in patients with irritable bowel syndrome and its subtypes.
abstract: BACKGROUND
  Irritable bowel syndrome (IBS) and celiac disease (CD) share some gastrointestinal symptoms. Celiac disease should be considered in a differential diagnosis of IBS.
  
  
  OBJECTIVE
  To estimate the prevalence of predispositions to CD in patients with IBS and its subtypes.
  
  
  METHODS
  The study included 48 patients (40 women, 8 men; average age: 41.1 ±14.6 years) with IBS, and a control group: 20 healthy volunteers. All participants completed a questionnaire on their current gastrointestinal symptoms and had a blood sample taken to determine the HLA-DQ2/DQ8 antigens and serum concentration of anti-tTG IgA and anti-DGP IgA and IgG.
  
  
  RESULTS
  The presence of HLA-DQ2 or DQ8 was found in 50% of patients (n= 24) with IBS. In the control group the presence of HLA-DQ2 was found in 4 (20%) patients and nobody had HLA-DQ8. Increased levels of anti-tTG IgA were found in 5 (10.42%) patients with IBS, anti-DGP in 4 (8.33%), and anti-DGP IgG in 3 (6.25%). In the control group positive test result for anti-tTG was found in 2 (10%) patients; nobody had elevated anti-DGP IgA or IgG. A concomitant positive result of genetic testing and any elevated serum antibodies specific to CD was found in 12.5% of IBS patients (n= 6) and in none of the control group.
  
  
  CONCLUSIONS
  Patients with IBS, regardless of the subtype, significantly more often than healthy controls have the predisposing genetic factors (HLA-DQ2/DQ8) underlying the development of CD.
authors.affiliation: Department of Digestive Tract Diseases, Medical University of Lodz, Lodz, Poland.
authors.forename: Danuta
authors.initials: D
authors.lastname: Domżał-Magrowska
authors.affiliation: Department of Digestive Tract Diseases, Medical University of Lodz, Lodz, Poland.
authors.forename: Marek K
authors.initials: MK
authors.lastname: Kowalski
authors.affiliation: Department of Biopharmacy, Medical University of Lodz, Lodz, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Szcześniak
authors.affiliation: Department of Biopharmacy, Medical University of Lodz, Lodz, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Bulska
authors.affiliation: Department of Biopharmacy, Medical University of Lodz, Lodz, Poland.
authors.forename: Daria
authors.initials: D
authors.lastname: Orszulak-Michalak
authors.affiliation: Department of Digestive Tract Diseases, Medical University of Lodz, Lodz, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Małecka-Panas
keywords: HLA-DQ2/DQ8; anti-DGP; anti-tTG; celiac disease; irritable bowel syndrome