title: CORRELATION BETWEEN PRE AND POSTOPERATIVE LEVELS OF GLP-1/GLP-2 AND WEIGHT LOSS AFTER ROUX-EN-Y GASTRIC BYPASS: A PROSPECTIVE STUDY.
abstract: The role of gut hormones in glucose homeostasis and weight loss achievement and maintenance after bariatric surgery appears to be a key point in the understanding of the beneficial effects observed following these procedures.
  
  
  
  To determine whether there is a correlation between the pre and postoperative levels of both GLP-1 and GLP-2 and the excess weight loss after Roux-en-Y gastric bypass (RYGB).
  
  
  
  An exploratory prospective study which enrolled 11 individuals who underwent RYGB and were followed-up for 12 months. GLP-1 and GLP-2 after standard meal tolerance test (MTT) were determined before and after surgery and then correlated with the percentage of excess loss (%EWL).
  
  
  
  GLP-2 AUC presented a significant postoperative increase (945.3±449.1 vs.1787.9±602.7; p=0.0037); GLP-1 AUC presented a non-significant trend towards increase after RYGB (709.6±320.4 vs. 1026.5±714.3; p=0.3808). Mean %EWL was 66.7±12.2%. There was not any significant correlation between both the pre and postoperative GLP-1 AUCs and GLP-2 AUCs and the %EWL achieved after one year.
  
  
  
  There was no significant correlation between the pre and postoperative levels of the areas under the GLP-1 and GLP-2 curves with the percentage of weight loss reached after one year.
authors.affiliation: Department of Surgery.
authors.forename: Everton
authors.initials: E
authors.lastname: Cazzo
authors.affiliation: Department of Surgery.
authors.forename: Martinho Antonio
authors.initials: MA
authors.lastname: Gestic
authors.affiliation: Department of Surgery.
authors.forename: Murillo Pimentel
authors.initials: MP
authors.lastname: Utrini
authors.affiliation: Department of Surgery.
authors.forename: José Carlos
authors.initials: JC
authors.lastname: Pareja
authors.affiliation: Department of Surgery.
authors.forename: Elinton Adami
authors.initials: EA
authors.lastname: Chaim
authors.affiliation: Research Laboratory in Metabology and Diabetes (Limed), State University of Campinas - Unicamp, Campinas, SP, Brazil.
authors.forename: Bruno
authors.initials: B
authors.lastname: Geloneze
authors.affiliation: Department of Surgery.
authors.forename: Maria Rita Lazzarini
authors.initials: MR
authors.lastname: Barreto
authors.affiliation: Department of Surgery.
authors.forename: Daniéla Oliveira
authors.initials: DO
authors.lastname: Magro
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D015390:Gastric Bypass; D052216:Glucagon-Like Peptide 1 / Q000097:blood*; D053767:Glucagon-Like Peptide 2 / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000097:blood* / Q000601:surgery*; D011184:Postoperative Period; D057234:Preoperative Period; D011446:Prospective Studies; D015431:Weight Loss; D055815:Young Adult
chemical_list: D053767:Glucagon-Like Peptide 2; D052216:Glucagon-Like Peptide 1