title: Chemistry and biology of ω-3 PUFA peroxidation-derived compounds.
abstract: The ω-3 polyunsaturated fatty acids (PUFAs) are among the most popular dietary supplements in the US, but they are chemically unstable and highly prone to lipid peroxidation. Many studies performed in different countries demonstrate that the majority of ω-3 PUFA products on the market are oxidized, suggesting that the resulting ω-3 PUFA peroxidation-derived compounds could be widely consumed by the general public. Therefore, it is of practical importance to understand the effects of these oxidized lipid compounds on human health. In this review, we summarize and discuss the chemical structures and biological activities of ω-3 PUFA peroxidation-derived compounds, and emphasize the importance to better understand the role of lipid peroxidation in biological activities of ω-3 PUFAs.
authors.affiliation: Department of Food Science, University of Massachusetts, Amherst, MA, USA.
authors.forename: Weicang
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Food Science, University of Massachusetts, Amherst, MA, USA.
authors.forename: Haixia
authors.initials: H
authors.lastname: Yang
authors.affiliation: Department of Food Science, University of Massachusetts, Amherst, MA, USA.
authors.forename: David
authors.initials: D
authors.lastname: Johnson
authors.affiliation: Department of Food Science, University of Massachusetts, Amherst, MA, USA.
authors.forename: Catherine
authors.initials: C
authors.lastname: Gensler
authors.affiliation: Department of Food Science, University of Massachusetts, Amherst, MA, USA.
authors.forename: Eric
authors.initials: E
authors.lastname: Decker
authors.affiliation: Department of Food Science, University of Massachusetts, Amherst, MA, USA. Electronic address: guodongzhang@umass.edu.
authors.forename: Guodong
authors.initials: G
authors.lastname: Zhang
mesh_terms: D000818:Animals; D015525:Fatty Acids, Omega-3 / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D015227:Lipid Peroxidation
chemical_list: D015525:Fatty Acids, Omega-3
keywords: Docosahexaenoic acid (DHA); Eicosapentaenoic acid (EPA); Lipid peroxidation; ω-3 polyunsaturated fatty acids