title: Heart-Type Fatty Acid Binding Protein Level as a Tool in Identification of Early Cardiac Effects of Diabetic Ketoacidosis.
abstract: OBJECTIVE
  This study aimed to measure the serum levels of heart-type fatty acid binding protein (H-FABP) in patients presenting with diabetic ketoacidosis (DKA) and diabetic ketosis (DK) and to determine its role in identifying early-period cardiac ischemia.
  
  
  METHODS
  This prospective study included 35 patients diagnosed with DKA, 20 patients diagnosed with DK, and 20 control subjects. H-FABP, creatine kinase-MB (CK-MB), and troponin I levels were investigated at presentation in patients with DKA and DK and in the control group. H-FABP values were measured again after acidosis correction in the DKA patients.
  
  
  RESULTS
  No statistically significant differences were found with respect to troponin I and CK-MB within the groups. The H-FABP values of DKA patients at presentation were found to be significantly higher than those of DK patients and the control group (p=0.015). The H-FABP value of the DKA group was also found to be significantly higher than the value at hour 36 after acidosis correction (p=0.0001).
  
  
  CONCLUSIONS
  We would like to propose H-FABP as a potential marker for indicating myocardial ischemia.
authors.affiliation: Selçuk University Faculty of Medicine, Department of Child Health and Diseases, Konya, Turkey, Phone: 0090332 224 39 88 E-mail: f.h.yilmaz@hotmail.com.
authors.forename: Fatma Hilal
authors.initials: FH
authors.lastname: Yılmaz
authors.forename: Sevil
authors.initials: S
authors.lastname: Arı Yuca
authors.forename: Hüsamettin
authors.initials: H
authors.lastname: Vatansev
authors.forename: Emine Ayça
authors.initials: EA
authors.lastname: Cimbek
authors.forename: Yaşar
authors.initials: Y
authors.lastname: Şen
authors.forename: İsa
authors.initials: İ
authors.lastname: Yılmaz
authors.forename: Fikret
authors.initials: F
authors.lastname: Akyürek
authors.forename: Derya
authors.initials: D
authors.lastname: Arslan
authors.forename: Derya
authors.initials: D
authors.lastname: Çimen
authors.forename: Alaaddin
authors.initials: A
authors.lastname: Yorulmaz
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D052279:Creatine Kinase, MB Form / Q000097:blood; D016883:Diabetic Ketoacidosis / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D042241:Early Diagnosis; D000074026:Fatty Acid Binding Protein 3 / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D017202:Myocardial Ischemia / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D011446:Prospective Studies; D019210:Troponin I / Q000097:blood
chemical_list: D015415:Biomarkers; D000074026:Fatty Acid Binding Protein 3; D019210:Troponin I; D052279:Creatine Kinase, MB Form
keywords: Heart-type fatty acid binding protein; child diabetic ketoacidosis.