title: Construction of the Azacyclic Core of Tabernaemontanine-Related Alkaloids via Tandem Reformatsky-Aza-Claisen Rearrangement.
abstract: A divergent synthetic methodology for a tabernaemontanine-related alkaloid was developed. The synthetic route features practical improvements in the Pictet-Spengler cyclization for the tetrahydro-β-carboline intermediate and an unprecedented tandem Reformatsky-aza-Claisen rearrangement to create the core carbon skeleton and stereochemistries of tabernaemontanine-related alkaloids.
authors.affiliation: College of Pharmacy, Seoul National University , 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea.
authors.forename: Young-Ger
authors.identifier: 0000-0003-1799-8607
authors.initials: YG
authors.lastname: Suh
authors.affiliation: College of Pharmacy, Seoul National University , 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea.
authors.forename: Changjin
authors.initials: C
authors.lastname: Lim
authors.affiliation: College of Pharmacy, Seoul National University , 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea.
authors.forename: Jaehoon
authors.initials: J
authors.lastname: Sim
authors.affiliation: Neuro-Medicine Center, Korea Institute of Science and Technology , P.O. Box 131, Seoul 130-650, Republic of Korea.
authors.forename: Jae Kyun
authors.initials: JK
authors.lastname: Lee
authors.affiliation: Tumor Microenvironment Global Core Research Center, College of Pharmacy, Seoul National University , 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea.
authors.forename: Young-Joon
authors.initials: YJ
authors.lastname: Surh
authors.affiliation: College of Pharmacy, Research Institute of Pharmaceutical Science, Gyeongsang National University , Jinju daero, Jinju 660-751, Republic of Korea.
authors.forename: Seung-Mann
authors.initials: SM
authors.lastname: Paek