title: Resting-State Functional Connectivity and Cognitive Impairment in Children with Perinatal Stroke.
abstract: Perinatal stroke is a leading cause of congenital hemiparesis and neurocognitive deficits in children. Dysfunctions in the large-scale resting-state functional networks may underlie cognitive and behavioral disability in these children. We studied resting-state functional connectivity in patients with perinatal stroke collected from the Estonian Pediatric Stroke Database. Neurodevelopment of children was assessed by the Pediatric Stroke Outcome Measurement and the Kaufman Assessment Battery. The study included 36 children (age range 7.6-17.9 years): 10 with periventricular venous infarction (PVI), 7 with arterial ischemic stroke (AIS), and 19 controls. There were no differences in severity of hemiparesis between the PVI and AIS groups. A significant increase in default mode network connectivity (FDR 0.1) and lower cognitive functions (p< 0.05) were found in children with AIS compared to the controls and the PVI group. The children with PVI had no significant differences in the resting-state networks compared to the controls and their cognitive functions were normal. Our findings demonstrate impairment in cognitive functions and neural network profile in hemiparetic children with AIS compared to children with PVI and controls. Changes in the resting-state networks found in children with AIS could possibly serve as the underlying derangements of cognitive brain functions in these children.
authors.affiliation: Department of Radiology, University of Tartu, Tartu, Estonia.
authors.forename: Nigul
authors.initials: N
authors.lastname: Ilves
authors.affiliation: Department of Radiology, University of Tartu, Tartu, Estonia; Radiology Clinic of Tartu University Hospital, Tartu, Estonia.
authors.forename: Pilvi
authors.identifier: 0000-0002-0094-4998
authors.initials: P
authors.lastname: Ilves
authors.affiliation: Department of Pediatrics, University of Tartu, Tartu, Estonia; Children's Clinic of Tartu University Hospital, Tartu, Estonia.
authors.forename: Rael
authors.initials: R
authors.lastname: Laugesaar
authors.affiliation: Department of Radiology, University of Tartu, Tartu, Estonia.
authors.forename: Julius
authors.initials: J
authors.lastname: Juurmaa
authors.affiliation: Department of Development and Rehabilitation Centre of Children and Adolescents, Children's Clinic of Tartu University Hospital, Tartu, Estonia; Institute of Psychology, University of Tallinn, Tallinn, Estonia.
authors.forename: Mairi
authors.initials: M
authors.lastname: Männamaa
authors.affiliation: Department of Pediatric Neurology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
authors.forename: Silva
authors.initials: S
authors.lastname: Lõo
authors.affiliation: Radiology Clinic of Tartu University Hospital, Tartu, Estonia.
authors.forename: Dagmar
authors.initials: D
authors.lastname: Loorits
authors.affiliation: Radiology Clinic of Tartu University Hospital, Tartu, Estonia.
authors.forename: Tiiu
authors.initials: T
authors.lastname: Tomberg
authors.affiliation: Department of Pediatrics, University of Tartu, Tartu, Estonia; Department of Neurology and Neurorehabilitation, Children's Clinic of Tartu University Hospital, Tartu, Estonia.
authors.forename: Anneli
authors.initials: A
authors.lastname: Kolk
authors.affiliation: Tallinn Children's Hospital, Tallinn, Estonia.
authors.forename: Inga
authors.initials: I
authors.lastname: Talvik
authors.affiliation: Department of Pediatrics, University of Tartu, Tartu, Estonia; Children's Clinic of Tartu University Hospital, Tartu, Estonia.
authors.forename: Tiina
authors.initials: T
authors.lastname: Talvik
mesh_terms: D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D003071:Cognition / Q000502:physiology*; D060825:Cognitive Dysfunction / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D009415:Nerve Net / Q000503:physiopathology; D009434:Neural Pathways / Q000503:physiopathology*; D009483:Neuropsychological Tests; D012146:Rest; D020521:Stroke / Q000150:complications / Q000503:physiopathology*