title: Picroside II protects against sepsis via suppressing inflammation in mice.
abstract: Picroside II, an iridoid compound extracted from Picrorhiza, exhibits anti-inflammatory and anti-apoptotic activities. We explored the protective effects and mechanisms of picroside II in a mouse model of sepsis induced by cecal ligation and puncture (CLP), using three groups of mice: Group A (sham), Group B (CLP+NS) and Group C (CLP+20 mg/kg picroside II). The mortality in mice with sepsis was decreased by the administration of picroside II, and lung injury was alleviated simultaneously. Picroside II treatment enhanced bacterial clearance in septic mice. Further, picroside II treatment alleviated the inflammatory response in sepsis and enhanced immune function by inhibiting the activation of NLRP3 inflammasome and NF-κB pathways. Picroside II may represent an anti-inflammatory drug candidate, providing novel insight into the treatment of sepsis.
authors.affiliation: Jiangsu Province Key Laboratory of Anesthesiology and Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical UniversityXuzhou, China; Department of Anesthesiology and SICU, Xinhua Hospital, School of Medicine, Shanghai Jiaotong UniversityShanghai, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Department of Anesthesiology and SICU, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University Shanghai, China.
authors.forename: Miao
authors.initials: M
authors.lastname: Zhou
authors.affiliation: Department of Medicine, Hebei North University Zhangjiakou, Hebei, China.
authors.forename: Chengbao
authors.initials: C
authors.lastname: Li
authors.affiliation: Jiangsu Province Key Laboratory of Anesthesiology and Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University Xuzhou, China.
authors.forename: Yuanli
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Medicine, Hebei North University Zhangjiakou, Hebei, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Fang
authors.affiliation: Department of General Surgery, Huai'an First People's Hospital, Nanjing Medical University Huai'an, China.
authors.forename: Guo
authors.initials: G
authors.lastname: Xu
authors.affiliation: Jiangsu Province Key Laboratory of Anesthesiology and Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical UniversityXuzhou, China; Department of Anesthesiology and SICU, Xinhua Hospital, School of Medicine, Shanghai Jiaotong UniversityShanghai, China; Department of Anesthesiology, Changzheng Hospital, Second Military Medical UniversityShanghai, China.
authors.forename: Xueyin
authors.initials: X
authors.lastname: Shi
keywords: NF-κB pathways; NLRP3; Picroside II; apoptosis; inflammation; sepsis