title: Assignment of polymorphic species of insulin analogues in ion mobility mass spectroscopy.
abstract: Electrospray ionization - ion mobility spectrometry - mass spectrometry (ESI-IMS-MS) allows the identification of protein polymorphic distribution of protein conformers and oligomers. We report the detailed identification of the species observed with commercially available pharmaceutical preparation of wild-type, regular human insulin.
authors.affiliation: Federal University of Rio de Janeiro - UFRJ, Av. Carlos Chagas Filho 373, CCS, Bss24, Ilha do Fundão, 21941-590 Rio de Janeiro, RJ, Brazil; Brazilian National Cancer Institute (INCA), 20230-014 Rio de Janeiro, RJ, Brazil.
authors.forename: Maely P
authors.initials: MP
authors.lastname: Fávero-Retto
authors.affiliation: Federal University of Rio de Janeiro - UFRJ, Av. Carlos Chagas Filho 373, CCS, Bss24, Ilha do Fundão, 21941-590 Rio de Janeiro, RJ, Brazil; Department of Chemistry, Institute of Exact Sciences, Rural Federal University of Rio de Janeiro - UFRRJ, Rodovia BR 465, km 7, CEP:23890-000 Seropédica, RJ, Brazil.
authors.forename: Luiz Henrique
authors.initials: LH
authors.lastname: Guerreiro
authors.affiliation: Federal University of Rio de Janeiro - UFRJ, Av. Carlos Chagas Filho 373, CCS, Bss24, Ilha do Fundão, 21941-590 Rio de Janeiro, RJ, Brazil.
authors.forename: Cássio M
authors.initials: CM
authors.lastname: Pessanha
authors.affiliation: Federal University of Rio de Janeiro - UFRJ, Av. Carlos Chagas Filho 373, CCS, Bss24, Ilha do Fundão, 21941-590 Rio de Janeiro, RJ, Brazil.
authors.forename: Leonardo C
authors.initials: LC
authors.lastname: Palmieri
authors.affiliation: Federal University of Rio de Janeiro - UFRJ, Av. Carlos Chagas Filho 373, CCS, Bss24, Ilha do Fundão, 21941-590 Rio de Janeiro, RJ, Brazil; Laboratory for Macromolecules (LAMAC-DIMAV), Brazilian National Institute of Metrology, Quality and Technology - INMETRO, Av. N. Sa. das Graças, 50 - Xerém, Duque de Caxias 25250-020, Rio de Janeiro, Brazil; National Institute of Science and Technology for Structural Biology and Bioimaging (INBEB-INCT), Federal University of Rio de Janeiro, Rio de Janeiro 21941-590, Brazil.
authors.forename: Luís Maurício T R
authors.initials: LM
authors.lastname: Lima