title: Expression of serum microRNA-378 and its clinical significance in laryngeal squamous cell carcinoma.
abstract: Studies have demonstrated that miRNA -378 expressed in various malignant tumors. In the present study, we aim to explore the expression of serum miRNA-378 and its clinical significance in laryngeal squamous cell carcinoma (LSCC) patients.
  
  
  
  A total of 127 LSCC patients, 127 vocal cord polyp (VCP) and 130 healthy controls were selected.
  
  
  
  The miRNA-378 level in LSCC and VCP group was significantly higher compared to healthy control, and LSCC group has the highest miRNA-378 level. The miRNA-378 level was both decreased significantly in LSCC and VCP group when compared with the same group after surgery. When compared with healthy control, VCP group has a higher miRNA-378 level but has no statistical difference (p>0.05) while LSCC group has a statistical difference (p<0.05) higher miRNA-378 compare with healthy control. The miRNA-378 expression is correlated with clinical stage and differentiation degree, but did not correlate with patient's age, gender distribution, operation mode, and tumor diameter. The AUC of miRNA-378 was 0.888, 95% confidence interval was 0.849 to 0.929, and AUC hypothesis testing was statistically significant (p<0.001).
  
  
  
  miRNA-378 could be used in the diagnosis and the prediction of the postoperative curative effect of laryngeal cancer (LSCC).
authors.affiliation: Department of Otorhinolaryngology, Department of Neurosurgery; Tianjin Medical University General Hospital, Tianjin, China. huifzhou667@163.com.
authors.forename: Y
authors.initials: Y
authors.lastname: Xu
authors.forename: Y-P
authors.initials: YP
authors.lastname: Lin
authors.forename: D
authors.initials: D
authors.lastname: Yang
authors.forename: G
authors.initials: G
authors.lastname: Zhang
authors.forename: H-F
authors.initials: HF
authors.lastname: Zhou
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics*; D035683:MicroRNAs / Q000378:metabolism*
chemical_list: C526012:MIRN378 microRNA, human; D035683:MicroRNAs