title: Prevalence of low HDL cholesterol and its associations among Sri Lankan patients with diabetes mellitus on statin therapy.
abstract: OBJECTIVE
  We aimed to study the prevalence and associations of suboptimal high density lipoproteins level, a characteristic feature in diabetic dyslipidemia among patients under statin therapy.
  
  
  METHODS
  From a database of 2416 patients, data on age, gender, duration of diabetes, body mass index (BMI) and waist circumference (WC), low density lipoproteins (LDL), triglyceride, high density lipoproteins (HDL) were obtained. Prevalence of suboptimal HDL (<40mg/dL in males and <50mg/dL in females) and its association with gender, age, duration of diabetes, BMI and WC were studied.
  
  
  RESULTS
  The mean (SD) age of the sample (n=2416) was 53 (10) years and 64.2% of them (n=1550) were males. Prevalence of suboptimal HDL was 17.6%. Regression analysis revealed female gender, (OR 7.73, 95% CI 5.99-9.97) younger age (OR 0.98, 95% CI 0.97-0.99), higher BMI (OR1.05. 95% CI 1.00-1.2) and LDL level over 100mg/dL (OR 1.004, 95% CI 1.00-1.007) had significant associations with suboptimal HDL.
  
  
  CONCLUSIONS
  Every sixth diabetic patient on statins has suboptimal HDL level. Females, younger and obese diabetic individuals should be more focused on achieving optimal HDL cholesterol levels.
authors.affiliation: Department of Medicine, Faculty of Medicine, PO Box 70, Galle, Sri Lanka. Electronic address: thilak.priyantha@yahoo.com.
authors.forename: Thilak Priyantha
authors.initials: TP
authors.lastname: Weerarathna
authors.affiliation: Department of Medicine, Faculty of Medicine, PO Box 70, Galle, Sri Lanka. Electronic address: herath1972@yahoo.co.uk.
authors.forename: Herath Mudiyanselage Meththananda
authors.initials: HMM
authors.lastname: Herath
authors.affiliation: Department of Pharmacology, Faculty of Medicne, PO Box 70, Galle, Sri Lanka. Electronic address: gayanicl@yahoo.com.
authors.forename: Gayani
authors.initials: G
authors.lastname: Liyanage
mesh_terms: D002318:Cardiovascular Diseases / Q000097:blood* / Q000453:epidemiology / Q000209:etiology; D008076:Cholesterol, HDL / Q000097:blood*; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications / Q000188:drug therapy*; D050171:Dyslipidemias / Q000097:blood* / Q000453:epidemiology / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D015995:Prevalence; D011379:Prognosis; D012307:Risk Factors; D013188:Sri Lanka / Q000453:epidemiology
chemical_list: D008076:Cholesterol, HDL; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors
keywords: Diabetic dyslipidemia; High density lipoproteins; South Asians; Sri Lankan; Statin therapy