title: Clinical management of genital chronic GvHD.
abstract: Chronic GvHD (cGvHD) of the genital tract is an underreported and infrequently recognized complication of allogeneic hematopoietic cell transplantation in both male and female long-term survivors. Its pathophysiology, clinical manifestations and management are not well understood, and studies are limited. We thus provide a comprehensive review of genital cGvHD in both men and women, as well as discuss related issues of sexual health and viral reactivation. We further provide guidance on screening, management and long-term follow-up, as well as future priority areas of study.
authors.affiliation: Blood &Marrow Transplant Program, Hematology and Medical Oncology, Cleveland Clinic, Taussig Cancer Institute, Cleveland, OH, USA.
authors.forename: B K
authors.initials: BK
authors.lastname: Hamilton
authors.affiliation: Obstetrics and Gynecology, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: O
authors.initials: O
authors.lastname: Goje
authors.affiliation: Division of Hematology/Oncology, Vanderbilt University Medical Center, Nashville, TN, USA.
authors.forename: B N
authors.initials: BN
authors.lastname: Savani
authors.affiliation: Blood &Marrow Transplant Program, Hematology and Medical Oncology, Cleveland Clinic, Taussig Cancer Institute, Cleveland, OH, USA.
authors.forename: N S
authors.initials: NS
authors.lastname: Majhail
authors.affiliation: Office of the Clinical Director, Intramural Program, National Institutes of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
authors.forename: P
authors.initials: P
authors.lastname: Stratton
mesh_terms: D064591:Allografts; D002908:Chronic Disease; D005260:Female; D005831:Genital Diseases, Female / Q000209:etiology / Q000628:therapy*; D005832:Genital Diseases, Male / Q000209:etiology / Q000628:therapy*; D006086:Graft vs Host Disease / Q000209:etiology / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male