title: Mitochondrial Repair Effects of Oxygen Treatment on Alzheimer's Disease Model Mice Revealed by Quantitative Proteomics.
abstract: Mitochondrial dysfunction plays a pivotal role in Alzheimer's disease (AD), even before signs of AD pathology are evident. Our previous research has shown that oxygen treatment can improve cognitive function in AD model mice. To address whether oxygen treatment is beneficial to mitochondrial biology, we analyzed differential expressions of hippocampal mitochondrial proteins in AD model mice given supplementary oxygen. Numerous respiratory chain, Kreb's cycle, and glycolysis proteins were upregulated significantly after oxygen treatment, suggesting that oxygen therapy can alleviate mitochondrial damage. Furthermore, the treatment was associated with decreased expressions of some AD biomarkers, suggesting oxygen treatment to be a potential therapy for AD.
authors.affiliation: College of Life Sciences and Oceanography, Shenzhen Key Laboratory of Microbial Genetic Engineering, Shenzhen University, Shenzhen, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.affiliation: College of Life Sciences and Oceanography, Shenzhen Key Laboratory of Microbial Genetic Engineering, Shenzhen University, Shenzhen, China.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Hong
authors.affiliation: College of Life Sciences and Oceanography, Shenzhen Key Laboratory of Marine Bioresources and Ecology, Shenzhen University, Shenzhen, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism* / Q000628:therapy*; D016564:Amyloid beta-Protein Precursor / Q000235:genetics / Q000378:metabolism; D000818:Animals; D004195:Disease Models, Animal; D006624:Hippocampus / Q000378:metabolism*; D006801:Humans; D008822:Mice, Transgenic; D008928:Mitochondria / Q000378:metabolism*; D010102:Oxygen Inhalation Therapy; D020543:Proteome; D040901:Proteomics; D016875:tau Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: C545487:APP protein, human; D016564:Amyloid beta-Protein Precursor; C054369:MAPT protein, human; D020543:Proteome; D016875:tau Proteins
keywords: Alzheimer’s disease; iTRAQ; mitochondria; oxidative phosphorylation; oxygen; proteomics