title: [Methodological guideline for the efficacy and safety assessment of new pharmaceuticals: implementation of EUnetHTA's recommendations].
abstract: The European network for Health Technology Assessment (EUnetHTA) is the network of public health technology assessment (HTA) agencies and entities from across the EU. In this context, the HTA Core Model®, has been developed. The Andalusian Agency for Health Technology Assessment (AETSA) is a member of the Spanish HTA Network and EUnetHTA collaboration In addition, AETSA participates in the new EUnetHTA Joint Action 3 (JA, 2016-2019). Furthermore, AETSA works on pharmaceutical assessments. Part of this work involves drafting therapeutic positioning reports (TPRs) on drugs that have recently been granted marketing authorisation, which is overseen by the Spanish Agency of Medicines and Medical Devices (AEMPS). AETSA contributes by drafting "Evidence synthesis reports: pharmaceuticals" in which a rapid comparative efficacy and safety assessment is performed for drugs for which a TPR will be created. To create this type of report, AETSA follows its own methodological guideline based on EUnetHTA guidelines and the HTA Core Model®. In this paper, the methodology that AETSA has developed to create the guideline for "Evidence synthesis reports: pharmaceuticals" is described. The structure of the report itself is also presented.
authors.affiliation: Servicio de Evaluación de Tecnologías Sanitarias, Agencia de Evaluación de Tecnologías Sanitarias de Andalucía (AETSA), Sevilla, España. Electronic address: ruth.ubago@juntadeandalucia.es.
authors.forename: Ruth
authors.initials: R
authors.lastname: Ubago Pérez
authors.affiliation: Servicio de Evaluación de Tecnologías Sanitarias, Agencia de Evaluación de Tecnologías Sanitarias de Andalucía (AETSA), Sevilla, España.
authors.forename: María Auxiliadora
authors.initials: MA
authors.lastname: Castillo Muñoz
authors.affiliation: Servicio de Evaluación de Tecnologías Sanitarias, Agencia de Evaluación de Tecnologías Sanitarias de Andalucía (AETSA), Sevilla, España.
authors.forename: Mercedes Galván
authors.initials: MG
authors.lastname: Banqueri
authors.affiliation: Servicio de Evaluación de Tecnologías Sanitarias, Agencia de Evaluación de Tecnologías Sanitarias de Andalucía (AETSA), Sevilla, España.
authors.forename: Raúl
authors.initials: R
authors.lastname: García Estepa
authors.affiliation: Servicio de Evaluación de Tecnologías Sanitarias, Agencia de Evaluación de Tecnologías Sanitarias de Andalucía (AETSA), Sevilla, España.
authors.forename: Eva Rocío
authors.initials: ER
authors.lastname: Alfaro Lara
authors.affiliation: Servicio de Evaluación de Tecnologías Sanitarias, Agencia de Evaluación de Tecnologías Sanitarias de Andalucía (AETSA), Sevilla, España.
authors.forename: María Dolores
authors.initials: MD
authors.lastname: Vega Coca
authors.affiliation: Servicio de Evaluación de Tecnologías Sanitarias, Agencia de Evaluación de Tecnologías Sanitarias de Andalucía (AETSA), Sevilla, España.
authors.forename: Carmen
authors.initials: C
authors.lastname: Beltrán Calvo
authors.affiliation: Servicio de Evaluación de Tecnologías Sanitarias, Agencia de Evaluación de Tecnologías Sanitarias de Andalucía (AETSA), Sevilla, España.
authors.forename: Teresa
authors.initials: T
authors.lastname: Molina López
mesh_terms: D004341:Drug Evaluation / Q000592:standards*; D005062:European Union; D019983:Guideline Adherence; D013673:Technology Assessment, Biomedical / Q000592:standards*
keywords: Comparative assessment; Efficacy and safety; Eficacia y seguridad; Evaluación comparada; Fármacos; Guideline; Guía; Methodology; Metodología; Pharmaceuticals