title: Specific patterns of neuronal loss in the pulvinar nucleus in dementia with lewy bodies.
abstract: Complex visual hallucinations occur in 70%-80% of dementia with Lewy bodies patients and significantly affect well-being. Despite the prevalence of visual hallucinations in dementia with Lewy bodies, the neuropathological basis of this phenomenon is poorly understood. The pulvinar nucleus of the thalamus has not previously been neuropathologically examined, but has been linked to visual hallucinations in dementia with Lewy bodies. The objective of this study was to investigate whether neuropathological or morphometric changes occur in the pulvinar nucleus in dementia with Lewy bodies cases that may contribute to visual hallucinations.
  
  
  
  Postmortem pulvinar tissue was acquired from 8 individuals with dementia with Lewy bodies, 8 with Alzheimer's disease, and 8 control cases and was analyzed using stereological and quantitative neuropathological techniques.
  
  
  
  Lewy body pathology was present throughout the pulvinar in dementia with Lewy bodies but was most severe in the medial pulvinar. Neuronal loss was found in the lateral pulvinar in dementia with Lewy bodies and Alzheimer's disease but was more severe in dementia with Lewy bodies.
  
  
  
  The pulvinar has an important role in visual attention, visual target selection and affective visual perception. These functions are thought to be deficient in dementia with Lewy bodies and may contribute a vulnerability to visual hallucinations. Therefore, this study has demonstrated neuropathological changes that may promote the manifestation of visual hallucinations in dementia with Lewy bodies. © 2017 International Parkinson and Movement Disorder Society.
authors.affiliation: Institute of Neuroscience, Ageing Research Laboratories, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom.|Medical Toxicology Centre, Wolfson Unit of Clinical Pharmacology, Newcastle University, Claremont Place, Newcastle upon Tyne, United Kingdom.
authors.forename: Daniel
authors.initials: D
authors.lastname: Erskine
authors.affiliation: Institute of Neuroscience, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom.
authors.forename: Alan J
authors.initials: AJ
authors.lastname: Thomas
authors.affiliation: Institute of Neuroscience, Ageing Research Laboratories, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom.
authors.forename: Johannes
authors.initials: J
authors.lastname: Attems
authors.affiliation: Institute of Neuroscience, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom.
authors.forename: John-Paul
authors.initials: JP
authors.lastname: Taylor
authors.affiliation: Institute of Neuroscience, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom.
authors.forename: Ian G
authors.initials: IG
authors.lastname: McKeith
authors.affiliation: Institute of Neuroscience, Ageing Research Laboratories, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom.|Medical Toxicology Centre, Wolfson Unit of Clinical Pharmacology, Newcastle University, Claremont Place, Newcastle upon Tyne, United Kingdom.
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Morris
authors.affiliation: Institute of Neuroscience, Ageing Research Laboratories, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom.
authors.forename: Ahmad A
authors.initials: AA
authors.lastname: Khundakar
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000473:pathology*; D005260:Female; D006212:Hallucinations / Q000209:etiology / Q000473:pathology*; D006801:Humans; D020961:Lewy Body Disease / Q000150:complications / Q000473:pathology*; D008297:Male; D020649:Pulvinar / Q000473:pathology*
keywords: Lewy body; dementia; pulvinar; stereology; synuclein; thalamus