title: Antidiabetic Effects of Resveratrol: The Way Forward in Its Clinical Utility.
abstract: Despite recent advances in the understanding and management ofdiabetes mellitus, the prevalence of the disease is increasing unabatedly with resulting disabling and life-reducing consequences to the global human population. The limitations and side effects associated with current antidiabetic therapies have necessitated the search for novel therapeutic agents. Due to the multipathogenicity ofdiabetes mellitus,plant-derived compounds with proven multiple pharmacological actions have been postulated to "hold the key" in the search for an affordable, efficacious, and safer therapeutic agent in the treatment of the disease and associated complications. Resveratrol, a phytoalexin present in few plant species, has demonstrated beneficial antidiabetic effects in animals and humans through diverse mechanisms and multiple molecular targets. However, despite the enthusiasm and widespread successes achieved with the use of resveratrol in animal models ofdiabetes mellitus, there are extremely limited clinical data to confirm the antidiabetic qualities of resveratrol. This review presents an update on the mechanisms of action and protection of resveratrol indiabetes mellitus, highlights challenges in its clinical utility, and suggests the way forward in translating the promising preclinical data to a possible antidiabetic drug in the near future.
authors.affiliation: Department of Biochemistry, Bowen University, Iwo, Nigeria.
authors.forename: Omolola R
authors.identifier: 0000-0001-6535-4289
authors.initials: OR
authors.lastname: Oyenihi
authors.affiliation: Discipline of Biochemistry, School of Life Sciences, University of KwaZulu-Natal, Westville Campus, Private Bag X54001, University Road, Durban 4000, South Africa.
authors.forename: Ayodeji B
authors.identifier: 0000-0001-9912-1539
authors.initials: AB
authors.lastname: Oyenihi
authors.affiliation: Department of Biochemistry, Bowen University, Iwo, Nigeria.
authors.forename: Anne A
authors.initials: AA
authors.lastname: Adeyanju
authors.affiliation: Nutrition and Chronic Disease Research Unit, Oxidative Stress Research Centre, Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Bellville, South Africa.
authors.forename: Oluwafemi O
authors.initials: OO
authors.lastname: Oguntibeju
mesh_terms: D000818:Animals; D003920:Diabetes Mellitus / Q000188:drug therapy*; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D000077185:Resveratrol; D013267:Stilbenes / Q000627:therapeutic use*
chemical_list: D007004:Hypoglycemic Agents; D013267:Stilbenes; D000077185:Resveratrol