title: AAPT Diagnostic Criteria for Chronic Sickle Cell Disease Pain.
abstract: Pain in sickle cell disease (SCD) is associated with increased morbidity, mortality, and high health care costs. Although episodic acute pain is the hallmark of this disorder, there is an increasing awareness that chronic pain is part of the pain experience of many older adolescents and adults. A common set of criteria for classifying chronic pain associated with SCD would enhance SCD pain research efforts in epidemiology, pain mechanisms, and clinical trials of pain management interventions, and ultimately improve clinical assessment and management. As part of the collaborative effort between the Analgesic, Anesthetic, and Addiction Clinical Trial Translations Innovations Opportunities and Networks public-private partnership with the U.S. Food and Drug Administration and the American Pain Society, the Analgesic, Anesthetic, and Addiction Clinical Trial Translations Innovations Opportunities and Networks-American Pain Society Pain Taxonomy initiative developed the outline of an optimal diagnostic system for chronic pain conditions. Subsequently, a working group of experts in SCD pain was convened to generate core diagnostic criteria for chronic pain associated with SCD. The working group synthesized available literature to provide evidence for the dimensions of this disease-specific pain taxonomy. A single pain condition labeled chronic SCD pain was derived with 3 modifiers reflecting different clinical features. Future systematic research is needed to evaluate the feasibility, validity, and reliability of these criteria.
  
  
  
  An evidence-based classification system for chronic SCD pain was constructed for the Analgesic, Anesthetic, and Addiction Clinical Trial Translations Innovations Opportunities and Networks-American Pain Society Pain Taxonomy initiative. Applying this taxonomy may improve assessment and management of SCD pain and accelerate research on epidemiology, mechanisms, and treatments for chronic SCD pain.
authors.affiliation: Emory University School of Medicine, Atlanta, Georgia.
authors.forename: Carlton
authors.initials: C
authors.lastname: Dampier
authors.affiliation: Seattle Children's Research Institute, Seattle, Washington. Electronic address: tonya.palermo@seattlechildrens.org.
authors.forename: Tonya M
authors.initials: TM
authors.lastname: Palermo
authors.affiliation: Children's National Medical Center, Washington, D.C.
authors.forename: Deepika S
authors.initials: DS
authors.lastname: Darbari
authors.affiliation: University of Colorado School of Medicine, Aurora, Colorado.
authors.forename: Kathryn
authors.initials: K
authors.lastname: Hassell
authors.affiliation: Virginia Commonwealth University Health System, Richmond, Virginia.
authors.forename: Wally
authors.initials: W
authors.lastname: Smith
authors.affiliation: Connecticut Children's Medical Center, Hartford, Connecticut.
authors.forename: William
authors.initials: W
authors.lastname: Zempsky
mesh_terms: D000755:Anemia, Sickle Cell / Q000150:complications* / Q000453:epidemiology; D059350:Chronic Pain / Q000175:diagnosis* / Q000201:enzymology / Q000209:etiology*; D019317:Evidence-Based Medicine; D006801:Humans; D010147:Pain Measurement / Q000379:methods* / Q000592:standards*; D055818:Public-Private Sector Partnerships; D012955:Societies, Medical / Q000592:standards*; D014481:United States; D014486:United States Food and Drug Administration / Q000592:standards
keywords: Sickle cell disease; chronic pain; diagnostic criteria; taxonomy