title: Distinct patterns of increased translocator protein in posterior cortical atrophy and amnestic Alzheimer's disease.
abstract: We sought to determine whether patients with posterior cortical atrophy (PCA) demonstrate a pattern of binding to translocator protein 18 kDa, a marker of microglial activation, that is distinct from that in patients with amnestic presentation of Alzheimer's disease (AD). Eleven PCA patients, 11 amnestic AD patients, and 15 age-matched controls underwent positron emission tomography with11C-PBR28 to measure translocator protein 18 kDa. PCA patients showed greater11C-PBR28 binding than controls in occipital, posterior parietal, and temporal regions. In contrast, amnestic AD patients showed greater11C-PBR28 binding in inferior and medial temporal cortex. Increased11C-PBR28 binding overlapped with reduced cortical volume for both PCA and amnestic AD patients, and with areas of reduced glucose metabolism in PCA patients. While both patient groups showed diffuse amyloid binding, PCA patients showed greater binding than amnestic AD patients in bilateral occipital cortex. These results suggest that microglial activation is closely associated with neurodegeneration across different subtypes of AD.
authors.affiliation: Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD, USA. Electronic address: wck2107@cumc.columbia.edu.
authors.forename: William C
authors.initials: WC
authors.lastname: Kreisl
authors.affiliation: Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD, USA.
authors.forename: Chul Hyoung
authors.initials: CH
authors.lastname: Lyoo
authors.affiliation: Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD, USA.
authors.forename: Jeih-San
authors.initials: JS
authors.lastname: Liow
authors.affiliation: Office of the Clinical Director, National Institute of Mental Health, Bethesda, MD, USA.
authors.forename: Joseph
authors.initials: J
authors.lastname: Snow
authors.affiliation: Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD, USA.
authors.forename: Emily
authors.initials: E
authors.lastname: Page
authors.affiliation: Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD, USA.
authors.forename: Kimberly J
authors.initials: KJ
authors.lastname: Jenko
authors.affiliation: Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD, USA.
authors.forename: Cheryl L
authors.initials: CL
authors.lastname: Morse
authors.affiliation: Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD, USA.
authors.forename: Sami S
authors.initials: SS
authors.lastname: Zoghbi
authors.affiliation: Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD, USA.
authors.forename: Victor W
authors.initials: VW
authors.lastname: Pike
authors.affiliation: Memory Disorders Program, Georgetown University, Washington, DC, USA.
authors.forename: R Scott
authors.initials: RS
authors.lastname: Turner
authors.affiliation: Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD, USA.
authors.forename: Robert B
authors.initials: RB
authors.lastname: Innis
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology*; D000682:Amyloid / Q000378:metabolism; D001284:Atrophy; D005260:Female; D005947:Glucose / Q000378:metabolism; D006801:Humans; D008297:Male; D017628:Microglia / Q000473:pathology; D008875:Middle Aged; D009410:Nerve Degeneration; D009778:Occipital Lobe / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology*; D049268:Positron-Emission Tomography; D011485:Protein Binding; D018079:Receptors, GABA / Q000378:metabolism*
chemical_list: D000682:Amyloid; D018079:Receptors, GABA; C499229:TSPO protein, human; D005947:Glucose
keywords: Alzheimer's disease; Neuroinflammation; PET imaging