title: PPARδas a Metabolic Initiator of Mammary Neoplasia and Immune Tolerance.
abstract: PPARδis a ligand-activated nuclear receptor that regulates the transcription of genes associated with proliferation, metabolism, inflammation, and immunity. Within this transcription factor family, PPARδis unique in that it initiates oncogenesis in a metabolic and tissue-specific context, especially in mammary epithelium, and can regulate autoimmunity in some tissues. This review discusses its role in these processes and how it ultimately impacts breast cancer.
authors.affiliation: Department of Oncology, Georgetown University Medical Center and the Lombardi Comprehensive Cancer Center, 3970 Reservoir Rd, NW, Washington, DC 20007, USA.
authors.forename: Robert I
authors.identifier: 0000-0001-6936-2980
authors.initials: RI
authors.lastname: Glazer