title: HDL efflux capacity, HDL particle size, and high-risk carotid atherosclerosis in a cohort of asymptomatic older adults: the Chicago Healthy Aging Study.
abstract: HDL efflux capacity and HDL particle size are associated with atherosclerotic CVD (ASCVD) events in middle-aged individuals; however, it is unclear whether these associations are present in older adults. We sampled 402 Chicago Healthy Aging Study participants who underwent a dedicated carotid MRI assessment for lipid-rich necrotic core (LRNC) plaque. We measured HDL particle size, HDL particle number, and LDL particle number with NMR spectroscopy, as well as HDL efflux capacity. We quantified the associations between HDL particle size and HDL efflux using adjusted linear regression models. We quantified associations between the presence of LRNC and HDL and LDL particle number, HDL particle size, and HDL efflux capacity using adjusted logistic regression models. HDL efflux capacity was directly associated with large (β = 0.037,P< 0.001) and medium (β = 0.0065,P= 0.002) HDL particle concentration and inversely associated with small (β = -0.0049,P= 0.018) HDL particle concentration in multivariable adjusted models. HDL efflux capacity and HDL particle number were inversely associated with prevalent LRNC plaque in unadjusted models (odds ratio: 0.5; 95% confidence interval: 0.26, 0.96), but not after multivariable adjustment. HDL particle size was not associated with prevalent LRNC. HDL particle size was significantly associated with HDL efflux capacity, suggesting that differences in HDL efflux capacity may be due to structural differences in HDL particles. Future research is needed to determine whether HDL efflux is a marker of ASCVD risk in older populations.
authors.affiliation: Department of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611.
authors.forename: R Kannan
authors.initials: RK
authors.lastname: Mutharasan
authors.affiliation: Department of Urology and Institute of BioNanotechnology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611.
authors.forename: C Shad
authors.initials: CS
authors.lastname: Thaxton
authors.affiliation: Department of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
authors.forename: Jarett
authors.initials: J
authors.lastname: Berry
authors.affiliation: Institute for Minority Health Research, University of Illinois College of Medicine, Chicago, IL 60612.
authors.forename: Martha L
authors.initials: ML
authors.lastname: Daviglus
authors.affiliation: University of Washington College of Engineering and University of Washington School of Medicine, University of Washington, Seattle, WA 98195.
authors.forename: Chun
authors.initials: C
authors.lastname: Yuan
authors.affiliation: University of Washington College of Engineering and University of Washington School of Medicine, University of Washington, Seattle, WA 98195.
authors.forename: Jie
authors.initials: J
authors.lastname: Sun
authors.affiliation: Department of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
authors.forename: Colby
authors.initials: C
authors.lastname: Ayers
authors.affiliation: Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611.
authors.forename: Donald M
authors.initials: DM
authors.lastname: Lloyd-Jones
authors.affiliation: Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 jwilkins@nm.org.
authors.forename: John T
authors.initials: JT
authors.lastname: Wilkins
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood* / Q000473:pathology; D015415:Biomarkers / Q000097:blood; D002340:Carotid Artery Diseases / Q000097:blood* / Q000473:pathology; D002641:Chicago; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D010316:Particle Size; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008075:Lipoproteins, HDL
keywords: high density lipoprotein/structure; lipid/efflux; low density lipoprotein