title: Advanced structural neuroimaging in progressive supranuclear palsy: Where do we stand?
abstract: Progressive supranuclear palsy (PSP) is a progressive neurological disorder characterized by presence of supranuclear gaze palsy, early postural instability, parkinsonism and cognitive impairment. Advanced structural neuroimaging studies have demonstrated variable areas of grey and white matter involvement in PSP. Grey matter (GM) involvement is predominantly reported in the midbrain, subcortical structures such as thalamus and basal ganglia, and cerebellum. Most white matter (WM) tracts are also reported to be damaged in PSP. This review analyzes the published studies that have utilized advanced structural imaging techniques such as voxel based morphometry (VBM), diffusion tensor and diffusion weighted imaging (DTI, DWI), magnetic resonance volumetry (MRV), shape analysis, cortical thickness analysis and magnetic resonance morphometry in understanding the in vivo pathological changes in PSP and also discusses their clinical significance.
authors.affiliation: Department of Neurology, National Institute of Mental Health & Neurosciences, Hosur Road, Bangalore 560029, Karnataka, India; Department of Clinical Neurosciences, National Institute of Mental Health & Neurosciences, Hosur Road, Bangalore 560029, Karnataka, India.
authors.forename: Albert
authors.initials: A
authors.lastname: Stezin
authors.affiliation: Department of Neurology, National Institute of Mental Health & Neurosciences, Hosur Road, Bangalore 560029, Karnataka, India; Department of Clinical Neurosciences, National Institute of Mental Health & Neurosciences, Hosur Road, Bangalore 560029, Karnataka, India.
authors.forename: Abhishek
authors.initials: A
authors.lastname: Lenka
authors.affiliation: Department of Neurology, National Institute of Mental Health & Neurosciences, Hosur Road, Bangalore 560029, Karnataka, India; Department of Clinical Neurosciences, National Institute of Mental Health & Neurosciences, Hosur Road, Bangalore 560029, Karnataka, India.
authors.forename: Ketan
authors.initials: K
authors.lastname: Jhunjhunwala
authors.affiliation: Department of Neuroimaging & Interventional Radiology, National Institute of Mental Health & Neurosciences, Hosur Road, Bangalore 560029, Karnataka, India.
authors.forename: Jitender
authors.initials: J
authors.lastname: Saini
authors.affiliation: Department of Neurology, National Institute of Mental Health & Neurosciences, Hosur Road, Bangalore 560029, Karnataka, India. Electronic address: pal.pramod@rediffmail.com.
authors.forename: Pramod K
authors.initials: PK
authors.lastname: Pal
mesh_terms: D001284:Atrophy; D001921:Brain / Q000000981:diagnostic imaging*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods / Q000592:standards; D066128:Gray Matter / Q000000981:diagnostic imaging; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods* / Q000592:standards; D059906:Neuroimaging / Q000379:methods* / Q000592:standards; D013494:Supranuclear Palsy, Progressive / Q000000981:diagnostic imaging* / Q000503:physiopathology; D066127:White Matter / Q000000981:diagnostic imaging
keywords: Cortical atrophy; Cortical thickness; Diffusion tensor imaging; Diffusion weighted imaging; Magnetic resonance morphometry; Magnetic resonance volumetry; Progressive supranuclear palsy; Shape analysis; Voxel based morphometry