title: [HIV genetic subtypes and HIV drug resistance in China: a Meta-analysis].
abstract: Objective:To assess the relationship between HIV genetic subtypes and HIV resistance in China.Methods:The literature retrieval was conducted by using Chinese Science-Technology Journal Database (VIP), Wanfang Data, Chinese Journal Full-text Database (CNKI), PubMed and Web of Science to select the papers on the relationship between HIV subtypes and HIV drug resistance in China during 2005-2015. Eligible papers were included according to the inclusion. Meta-analysis was performed by using software Stata 12.0.Results:A total of 43 papers were selected and the pooled rate of drug resistance was 15.1% and the rate of primary drug resistance was 9.5%, the subtypes associated drug resistance were CRF01_AE, CRF07_BC, CRF08_ BC, B/B'and C. The pooled rates of drug resistance of each subtype were 12.8%, 7.4%, 14.3%, 25.7% and 34.9% and the rates of primary drug resistance of each subtype were 7.3%, 5.7%, 11.5%,15.5% and 23.9%, respectively. Subgroup analysis showed that both treated and area subgroup showed a significant difference among groups (P<0.05). The rates of primary resistance of each subtype in northern China and southwestern China were higher than that in southern China.Conclusion:The distribution of HIV genotypes in China was complex and the prevalence of primary drug resistance of each subtype was high, together with a significant difference among subtypes. It is necessary to strengthen the monitoring of different subtypes of drug resistant strains in China to prevent the recombination and spreading of resistant strains.
authors.affiliation: School of Public Health, Southeast University, Nanjing 210009, China.
authors.forename: N N
authors.initials: NN
authors.lastname: Wu
authors.forename: Y Q
authors.initials: YQ
authors.lastname: Yin
authors.forename: R
authors.initials: R
authors.lastname: Yuan
authors.forename: B
authors.initials: B
authors.lastname: Wang
mesh_terms: D044466:Asian People; D002681:China; D024882:Drug Resistance, Viral; D015658:HIV Infections; D015497:HIV-1; D006801:Humans; D008297:Male; D015995:Prevalence; D012984:Software