title: Skull Metastasis of Gastric Gastrointestinal Stromal Tumor Successfully Managed by Surgery.
abstract: Gastrointestinal stromal tumors (GISTs) are rare, but are the most common mesenchymal neoplasm of the gastrointestinal tract. The most common sites of metastasis are liver and peritoneum, while bone metastasis is rare. We report on a patient with skull metastasis after seven years of treatment with imatinib for metastatic GIST. She underwent metastasectomy consisting of craniectomy with excision of the mass, and cranioplasty and continued treatment with imatinib and sunitinib, without evidence of cranial recurrence. She died of pneumonia sepsis one year after metastasectomy. Skull metastasis of GIST is a very rare presentation, and an aggressive multidisciplinary approach should be considered whenever possible.
authors.affiliation: Division of Hematology-Oncology, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea.
authors.forename: Inkeun
authors.initials: I
authors.lastname: Park
authors.affiliation: Department of Internal Medicine, Pathology, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea.
authors.forename: Dong Hae
authors.initials: DH
authors.lastname: Chung
authors.affiliation: Department of Neurosurgery, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea.
authors.forename: Chan Jong
authors.initials: CJ
authors.lastname: Yoo
authors.affiliation: Division of Hematology-Oncology, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea.
authors.forename: Dong Bok
authors.initials: DB
authors.lastname: Shin
keywords: Gastrointestinal stromal tumor; Metastasectomy; Multidisciplinary treatment; Skull metastasis; Target therapy