title: CRP velocity and short-term mortality in ST segment elevation myocardial infarction.
abstract: BACKGROUND
  There is a known association between C-reactive protein (CRP) levels and adverse outcomes in patients presenting with ST-elevation myocardial infarction (STEMI). The optimal time frame to measure CRP for risk stratification is not known.
  
  
  OBJECTIVE
  The aim of the current study was to evaluate the relation between the change in CRP velocity (CRPv) and 30-d mortality among STEMI patients.
  
  
  METHODS
  We included consecutive patients with a diagnosis of STEMI who presented to Tel-Aviv Medical Center between 2008 and 2014 and had their CRP measured with a wide range assay (wr-CRP) at least twice during the 24 h after admission. CRPv was defined as the change in wr-CRP concentration (mg/l) divided by the change in time (in hours) between the two measurements.
  
  
  RESULTS
  The study population comprised of 492 patients, mean age was 62 ± 14, 80% were male. CRPv was significantly higher among patients who died within 30 d of admission (1.42 mg/l versus 0.18 mg/l, p < 0.001). In a multivariate regression model adjusted to multiple confounders, CRPv was independently associated with 30-d mortality (OR 1.39, 95% CI: 1.20-1.62, p < 0.001).
  
  
  CONCLUSIONS
  CRPv might be an independent and rapidly measurable biomarker for short-term mortality in patients presenting with STEMI.
authors.affiliation: a Department of Cardiology , Tel-Aviv Sourasky Medical Center affiliated with the Sackler Faculty of Medicine, Tel-Aviv University , Tel-Aviv , Israel.
authors.forename: Assi
authors.initials: A
authors.lastname: Milwidsky
authors.affiliation: b Department of Epidemiology and Preventative Medicine , School of Public Health, Sackler Faculty of Medicine, Tel Aviv University , Tel Aviv , Israel.
authors.forename: Tomer
authors.initials: T
authors.lastname: Ziv-Baran
authors.affiliation: a Department of Cardiology , Tel-Aviv Sourasky Medical Center affiliated with the Sackler Faculty of Medicine, Tel-Aviv University , Tel-Aviv , Israel.
authors.forename: Sevan
authors.initials: S
authors.lastname: Letourneau-Shesaf
authors.affiliation: a Department of Cardiology , Tel-Aviv Sourasky Medical Center affiliated with the Sackler Faculty of Medicine, Tel-Aviv University , Tel-Aviv , Israel.
authors.forename: Gad
authors.initials: G
authors.lastname: Keren
authors.affiliation: c Department of Internal Medicine "E" , Tel-Aviv Sourasky Medical Center affiliated with the Sackler Faculty of Medicine, Tel-Aviv University , Tel-Aviv , Israel.
authors.forename: Philippe
authors.initials: P
authors.lastname: Taieb
authors.affiliation: c Department of Internal Medicine "E" , Tel-Aviv Sourasky Medical Center affiliated with the Sackler Faculty of Medicine, Tel-Aviv University , Tel-Aviv , Israel.
authors.forename: Shlomo
authors.initials: S
authors.lastname: Berliner
authors.affiliation: a Department of Cardiology , Tel-Aviv Sourasky Medical Center affiliated with the Sackler Faculty of Medicine, Tel-Aviv University , Tel-Aviv , Israel.
authors.forename: Yacov
authors.initials: Y
authors.lastname: Shacham
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000032:analysis; D002097:C-Reactive Protein / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D000072657:ST Elevation Myocardial Infarction / Q000175:diagnosis / Q000401:mortality*; D013997:Time Factors
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein
keywords: C-reactive protein; CRP velocity; acute myocardial infarction; biomarkers; inflammation