title: Exploratory Factor Analysis for Validating Traditional Chinese Syndrome Patterns of Chronic Atrophic Gastritis.
abstract: Background.Traditional Chinese medicine (TCM) has long been used to treat chronic atrophic gastritis (CAG). The aim of the present study was to evaluate the TCM syndrome characteristics of CAG and its core pathogenesis so as to promote optimization of treatment strategies.Methods.This study was based on a participant survey conducted in 4 hospitals in China. Patients diagnosed with CAG were recruited by simple random sampling. Exploratory factor analysis (EFA) was conducted on syndrome extraction.Results.Common factors extracted were assigned to six syndrome patterns:qideficiency,qistagnation, blood stasis, phlegm turbidity, heat, andyangdeficiency. Distribution frequency of all syndrome patterns showed thatqideficiency,qistagnation, blood stasis, phlegm turbidity, and heat excess were higher (76.7%-84.2%) compared withyangdeficiency (42.5%). Distribution of main syndrome patterns showed that frequencies ofqideficiency,qistagnation, phlegm turbidity, heat, andyangdeficiency were higher (15.8%-20.8%) compared with blood stasis (8.3%).Conclusions.The core pathogenesis of CAG is combination ofqideficiency,qistagnation, blood stasis, phlegm turbidity, heat, andyangdeficiency. Therefore, treatment strategy of herbal prescriptions for CAG should include herbs that regulateqi, activate blood, resolve turbidity, clear heat, remove toxin, and warm yang.
authors.affiliation: Beijing University of Chinese Medicine, Chaoyang District, Beijing 100029, China; Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Dongcheng District, Beijing 100700, China.
authors.forename: Yin
authors.identifier: 0000-0002-0025-0873
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: School of Humanities, Beijing University of Chinese Medicine, Chaoyang District, Beijing 100029, China.
authors.forename: Ajian
authors.initials: A
authors.lastname: Zhou
authors.affiliation: Beijing University of Chinese Medicine, Chaoyang District, Beijing 100029, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Institute of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Chaoyang District, Beijing 100029, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Neurosurgery, China-Japan Friendship Hospital, Chaoyang District, Beijing 100029, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Institute of Systems Engineering, Faculty of Management and Economics, Dalian University of Technology, Ganjingzi District, Dalian 116024, China.
authors.forename: Leilei
authors.initials: L
authors.lastname: Sun
authors.affiliation: Department of Gastroenterology, China-Japan Friendship Hospital, Beijing 100029, China.
authors.forename: Shiyu
authors.initials: S
authors.lastname: Du
authors.affiliation: Department of Pathology, China-Japan Friendship Hospital, Chaoyang District, Beijing 100029, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Yang
authors.affiliation: Department of General Surgery, China-Japan Friendship Hospital, Chaoyang District, Beijing 100029, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Song
authors.affiliation: Department of Thoracic Surgery, China-Japan Friendship Hospital, Chaoyang District, Beijing 100029, China.
authors.forename: Chaoyang
authors.initials: C
authors.lastname: Liang
authors.affiliation: Beijing University of Chinese Medicine, Chaoyang District, Beijing 100029, China.
authors.forename: Xia
authors.identifier: 0000-0002-7346-942X
authors.initials: X
authors.lastname: Ding