title: Convergent gustatory and viscerosensory processing in the human dorsal mid-insula.
abstract: The homeostatic regulation of feeding behavior requires an organism to be able to integrate information from its internal environment, including peripheral visceral signals about the body's current energy needs, with information from its external environment, such as the palatability of energy-rich food stimuli. The insula, which serves as the brain's primary sensory cortex for representing both visceral signals from the body and taste signals from the mouth and tongue, is a likely candidate region in which this integration might occur. However, to date it has been unclear whether information from these two homeostatically critical faculties is merely co-represented in the human insula, or actually integrated there. Recent functional neuroimaging evidence of a common substrate for visceral interoception and taste perception within the human dorsal mid-insula suggests a model whereby a single population of neurons may integrate viscerosensory and gustatory signals. To test this model, we used fMRI-Adaptation to identify whether insula regions that exhibit repetition suppression following repeated interoception trials would then also exhibit adapted responses to subsequent gustatory stimuli. Multiple mid and anterior regions of the insula exhibited adaptation to interoceptive trials specifically, but only the dorsal mid-insula regions exhibited an adapted gustatory response following interoception. The discovery of this gustatory-interoceptive convergence within the neurons of the human insula supports the existence of a heretofore-undocumented neural pathway by which visceral signals from the periphery modulate the activity of brain regions involved in feeding behavior. Hum Brain Mapp 38:2150-2164, 2017. © 2017 Wiley Periodicals, Inc.
authors.affiliation: Laureate Institute for Brain Research, Tulsa, Oklahoma.|Department of Biological Sciences, The University of Tulsa, Tulsa, Oklahoma.
authors.forename: Jason A
authors.identifier: 0000-0003-4097-2819
authors.initials: JA
authors.lastname: Avery
authors.affiliation: Laboratory of Brain and Cognition, National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, Maryland.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Gotts
authors.affiliation: Laureate Institute for Brain Research, Tulsa, Oklahoma.|Department of Psychology, The University of Tulsa, Tulsa, Oklahoma.
authors.forename: Kara L
authors.initials: KL
authors.lastname: Kerr
authors.affiliation: Laureate Institute for Brain Research, Tulsa, Oklahoma.
authors.forename: Kaiping
authors.initials: K
authors.lastname: Burrows
authors.affiliation: Laboratory of Brain and Cognition, National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, Maryland.
authors.forename: John E
authors.initials: JE
authors.lastname: Ingeholm
authors.affiliation: Laureate Institute for Brain Research, Tulsa, Oklahoma.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Bodurka
authors.affiliation: Laboratory of Brain and Cognition, National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, Maryland.
authors.forename: Alex
authors.initials: A
authors.lastname: Martin
authors.affiliation: Laureate Institute for Brain Research, Tulsa, Oklahoma.|School of Community Medicine, The University of Tulsa, Tulsa, Oklahoma.
authors.forename: W
authors.initials: W
authors.lastname: Kyle Simmons
mesh_terms: D000222:Adaptation, Physiological; D000293:Adolescent; D000328:Adult; D000344:Afferent Pathways / Q000000981:diagnostic imaging / Q000502:physiology*; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000502:physiology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D065812:Interoception / Q000502:physiology; D008279:Magnetic Resonance Imaging; D008297:Male; D010775:Photic Stimulation; D012677:Sensation / Q000502:physiology; D013270:Stomach / Q000294:innervation; D013649:Taste / Q000502:physiology*; D055697:Taste Perception / Q000502:physiology*; D055815:Young Adult
keywords: fMRI; fMRI-adaptation; gustation; insular cortex; interoception