title: Correspondent Functional Topography of the Human Left Inferior Parietal Lobule at Rest and Under Task Revealed Using Resting-State fMRI and Coactivation Based Parcellation.
abstract: The human left inferior parietal lobule (LIPL) plays a pivotal role in many cognitive functions and is an important node in the default mode network (DMN). Although many previous studies have proposed different parcellation schemes for the LIPL, the detailed functional organization of the LIPL and the exact correspondence between the DMN and LIPL subregions remain unclear. Mounting evidence indicates that spontaneous fluctuations in the brain are strongly associated with cognitive performance at the behavioral level. However, whether a consistent functional topographic organization of the LIPL during rest and under task can be revealed remains unknown. Here, they used resting-state functional connectivity (RSFC) and task-related coactivation patterns separately to parcellate the LIPL and identified seven subregions. Four subregions were located in the supramarginal gyrus (SMG) and three subregions were located in the angular gyrus (AG). The subregion-specific networks and functional characterization revealed that the four anterior subregions were found to be primarily involved in sensorimotor processing, movement imagination and inhibitory control, audition perception and speech processing, and social cognition, whereas the three posterior subregions were mainly involved in episodic memory, semantic processing, and spatial cognition. The results revealed a detailed functional organization of the LIPL and suggested that the LIPL is a functionally heterogeneous area. In addition, the present study demonstrated that the functional architecture of the LIPL during rest corresponds with that found in task processing. Hum Brain Mapp 38:1659-1675, 2017. © 2017 Wiley Periodicals, Inc.
authors.affiliation: Key Laboratory for NeuroInformation of the Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 625014, China.
authors.forename: Jiaojian
authors.initials: J
authors.lastname: Wang
authors.affiliation: Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China.|National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China.
authors.forename: Sangma
authors.initials: S
authors.lastname: Xie
authors.affiliation: Key Laboratory for NeuroInformation of the Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 625014, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Guo
authors.affiliation: Key Laboratory for NeuroInformation of the Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 625014, China.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Becker
authors.affiliation: Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas.
authors.forename: Peter T
authors.initials: PT
authors.lastname: Fox
authors.affiliation: Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany.|Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University, Dusseldorf, Germany.
authors.forename: Simon B
authors.initials: SB
authors.lastname: Eickhoff
authors.affiliation: Key Laboratory for NeuroInformation of the Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 625014, China.|Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China.|National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China.|CAS Center for Excellence in Brain Science, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China.|The Queensland Brain Institute, University of Queensland, Brisbane, Queensland, 4072, Australia.
authors.forename: Tianzi
authors.initials: T
authors.lastname: Jiang
mesh_terms: D000293:Adolescent; D001931:Brain Mapping; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008959:Models, Neurological; D009415:Nerve Net / Q000000981:diagnostic imaging*; D010100:Oxygen / Q000097:blood; D010296:Parietal Lobe / Q000000981:diagnostic imaging*; D012146:Rest; D055815:Young Adult
chemical_list: D010100:Oxygen
keywords: coactivation; correspondent functional topography; left inferior parietal lobule; parcellation; resting-state