title: [Current Therapeutic Approaches to Sarcoidosis].
abstract: Sarcoidosis represents a non-caseating, granulomatous disorder of unknown aetiology whose clinical manifestation is heterogeneous and frequently multisystemic. The portion of patients needing systemic treatment varies: though many patients may undergo spontaneous remission, organ-threatening courses demand systemic therapy. Corticosteroids are the first-line treatment option; however, disease´s progression and/or major corticosteroid side effects may require second- and third-line therapeutics. A current stepwise therapeutic algorithm to sarcoidosis that characterizes additive and alternative therapeutic agents is given in the following review.
authors.forename: Carmen
authors.initials: C
authors.lastname: Pizarro
authors.forename: Dirk
authors.initials: D
authors.lastname: Skowasch
authors.forename: Christian
authors.initials: C
authors.lastname: Grohé
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D019317:Evidence-Based Medicine; D006801:Humans; D012507:Sarcoidosis / Q000175:diagnosis* / Q000188:drug therapy* / Q000517:prevention & control; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones