title: Herbal MedicineCordyceps sinensisImproves Health-Related Quality of Life in Moderate-to-Severe Asthma.
abstract: Moderate-to-severe asthma has a substantial impact on the health-related quality of life (HR-QOL) of the patients.Cordyceps sinensisis a traditional Chinese medicine that is evaluated clinically for the treatment of many diseases, such as chronic allograft nephropathy, diabetic kidney disease, and lung fibrosis. In order to investigate the effects ofCordyceps sinensison patients with moderate-to-severe persistent asthma, 120 subjects were randomized to receive Corbin capsule containingCordyceps sinensisfor 3 months (treatment group,n= 60), whereas the control group (n= 60) did not receive treatment with Corbin capsule. Inhaled corticosteroid and as-neededβ-agonists were used in the treatment of both groups. HR-QOL was measured with the Juniper's Asthma Quality of Life Questionnaire (AQLQ). The incidence of asthma exacerbation, pulmonary function testing, and serum measurements of inflammatory mediators were also evaluated. The results showed that the treatment group indicated a significant increase in AQLQ scores and lung function compared with the control group. The expression levels of the inflammation markers IgE, ICAM-1, IL-4, and MMP-9 in the serum were decreased and IgG increased in the treatment group compared with the control group. Therefore, the conclusion was reached that a formulation ofCordyceps sinensisimproved the HR-QOL, asthma symptoms, lung function, and inflammatory profile of the patients with moderate-to-severe asthma. This trial is registered with ChiCTR-IPC-16008730.
authors.affiliation: Department of Traditional Chinese Medicine, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing 100053, China.
authors.forename: Ningqun
authors.initials: N
authors.lastname: Wang
authors.affiliation: Department of Respiratory Medicine, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100700, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Traditional Chinese Medicine, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing 100053, China.
authors.forename: Xiaobo
authors.identifier: 0000-0001-5740-483X
authors.initials: X
authors.lastname: Huang
authors.affiliation: Department of Traditional Chinese Medicine, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing 100053, China.
authors.forename: Wenqiang
authors.initials: W
authors.lastname: Chen
authors.affiliation: Department of Traditional Chinese Medicine, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing 100053, China.
authors.forename: Yujing
authors.initials: Y
authors.lastname: Chen