title: Engaging Hmong adults in genomic and pharmacogenomic research: Toward reducing health disparities in genomic knowledge using a community-based participatory research approach.
abstract: Advancing precision medicine relies in part on examining populations that may exhibit unique genetic variants that impact clinical outcomes. Failure to include diverse populations in genomic-based research represents a health disparity. We implemented a community-based participatory research (CBPR) process with the Hmong community in Minnesota, who were refugees from Laos, in order to assess the feasibility of conducting genomic and pharmacogenomic-based research for genetic variants that are relevant to the Hmong community. Our Hmong Genomics Board, consisting of Hmong and non-Hmong professionals, used CBPR principles and built on previous formative research to create and implement culturally and linguistically appropriate informed consent processes for Hmong people at six community venues. The Board chose genetic variants for diabetes risk and warfarin response as relevant to the community. The Institutional Review Board approved aggregate but not individual return of results. Two hundred thirty-seven Hmong participants with mean (range) age of 30.2 (18-81) years and diverse levels of education (22% without and 75% with high-school education) provided saliva for genetic (DNA) analyses. Eighty-five percent of participants agreed to store DNA for future analyses, 82% agreed to share DNA with other researchers, and 78% agreed to be contacted for future studies. Twenty-five elders refused to participate because they wanted individual results. Aggregate results were shared with all participants. This CBPR approach proved highly successful to obtain informed consent and recruit a sample from the Hmong community for a genomic and pharmacogenomic study. Investment in the CBPR process may prove successful to address the gap of genomic information in under-represented communities.
authors.affiliation: West Side Community Health Services, 153 Cesar Chavez St, Saint Paul, MN, 55107, USA. kathiecp@yahoo.com.
authors.forename: Kathleen A
authors.initials: KA
authors.lastname: Culhane-Pera
authors.affiliation: Department of Experimental and Clinical Pharmacology, College of Pharmacy University of Minnesota, 7-115 Weaver-Densford Hall, 308 Harvard St SE, Minneapolis, MN, 55455, USA.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Straka
authors.affiliation: Benton County Health Services, 530 NW 27th St, Corvallis, OR, 97330, USA.
authors.forename: MaiKia
authors.initials: M
authors.lastname: Moua
authors.affiliation: Department of Experimental and Clinical Pharmacology, College of Pharmacy University of Minnesota, 7-115 Weaver-Densford Hall, 308 Harvard St SE, Minneapolis, MN, 55455, USA.
authors.forename: Youssef
authors.initials: Y
authors.lastname: Roman
authors.affiliation: University of Minnesota Medical Center-Fairview Campus, 2450 Riverside Ave, Minneapolis, MN, 55454, USA.
authors.forename: Pachia
authors.initials: P
authors.lastname: Vue
authors.affiliation: West Side Community Health Services, 153 Cesar Chavez St, Saint Paul, MN, 55107, USA.
authors.forename: Kang
authors.initials: K
authors.lastname: Xiaaj
authors.affiliation: Phalen Family Pharmacy, 1001 Johnson Parkway, St Paul, MN, 55106, USA.
authors.forename: May Xia
authors.initials: MX
authors.lastname: Lo
authors.affiliation: Department of Experimental and Clinical Pharmacology, College of Pharmacy University of Minnesota, 7-115 Weaver-Densford Hall, 308 Harvard St SE, Minneapolis, MN, 55455, USA.
authors.forename: Mai
authors.initials: M
authors.lastname: Lor
keywords: Community-based participatory research; Genomics; Hmong; Pharmacogenomics