title: Altered Brain Glucose Consumption in Cogan's Syndrome.
abstract: Purpose. Prospective, controlled cohort study to investigate possible alterations in brain glucose metabolism (CMRglc) in patients with Cogan's syndrome (CS).Patients and Methods. Functional mapping of the CMRglc was obtained by quantitative molecular imaging positron emission tomography, combined with computed tomography (FDG-PET/CT). The patients were divided into three clinical groups: typical CS; atypical CS (ACS); autoimmune inner ear disease (AIED). The unmatched control group (CG) consisted of subjects requiring FDG-PET/CT for an extracranial pathology. Statistical mapping searched areas of significant glucose hypometabolism in all the affected patients (DG) and in each clinical subgroup. The results were compared with those of the CG.Results. 44 patients were enrolled (DG) and assigned to the three study groups: 8 patients to the CS group; 21 patients to the ACS group; and 15 to the AIED group. Sixteen subjects formed the CG group. Areas of significant brain glucose hypometabolism were identified in all the study groups, with the largest number and extension in the DG and CS.Conclusions. This study revealed areas of significantly altered CMRglc in patients with CS (any subform) without neurologic complains and normal conventional neuroimaging. Our results suggest that FDG-PET/CT may represent a very useful tool for the global assessment of patients with Cogan's syndrome.
authors.affiliation: Institute of Ophthalmology, University Hospital of Parma, Parma, Italy.
authors.forename: Paolo
authors.identifier: 0000-0001-7133-8250
authors.initials: P
authors.lastname: Mora
authors.affiliation: Nuclear Medicine Unit, University Hospital of Parma, Parma, Italy.
authors.forename: Livia
authors.initials: L
authors.lastname: Ruffini
authors.affiliation: Medical Physic Department, University Hospital of Parma, Parma, Italy.
authors.forename: Caterina
authors.identifier: 0000-0002-1976-4540
authors.initials: C
authors.lastname: Ghetti
authors.affiliation: Institute of Ophthalmology, University Hospital of Parma, Parma, Italy.
authors.forename: Stella
authors.initials: S
authors.lastname: Ghirardini
authors.affiliation: Nuclear Medicine Unit, University Hospital of Parma, Parma, Italy.
authors.forename: Maura
authors.initials: M
authors.lastname: Scarlattei
authors.affiliation: Nuclear Medicine Unit, University Hospital of Parma, Parma, Italy.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Baldari
authors.affiliation: Nuclear Medicine Unit, University Hospital of Parma, Parma, Italy.
authors.forename: Carla
authors.initials: C
authors.lastname: Cidda
authors.affiliation: Institute of Ophthalmology, University Hospital of Parma, Parma, Italy.
authors.forename: Pierangela
authors.identifier: 0000-0001-5472-5064
authors.initials: P
authors.lastname: Rubino
authors.affiliation: Institute of Ophthalmology, University Hospital of Parma, Parma, Italy.
authors.forename: Stefano A
authors.initials: SA
authors.lastname: Gandolfi
authors.affiliation: Institute of Ophthalmology, University Hospital of Parma, Parma, Italy.
authors.forename: Jelka G
authors.initials: JG
authors.lastname: Orsoni