title: Long term outcome of medical and surgical co-management of craniospinal aspergillosis in an immunocompromised patient.
abstract: 35 yr old steroid dependent lady with Pulmonary TB underwent debridement of epidural abscess & posterior stabilization for paraparesis. With histopathology and cultures showing Aspergillus fumigatus, voricanozole was started. By the fourth week, she developed persistent fever, and altered mental status. Brain MRI and CSF study including multiplex PCR evaluation confirmed cerebral aspergillosis. Voricanozole was changed to intravenous lipid complex Amphotericin B to achieve sustained clinical and radiological response after six months of therapy.
authors.affiliation: Department of General Medicine, Amrita Institute of Medical Sciences and Research Centre, Ponekkara, Kochi 682041, India.
authors.forename: Dipu
authors.initials: D
authors.lastname: Sathyapalan
authors.affiliation: Department of Emergency Medicine, Amrita Institute of Medical Sciences and Research Centre, Ponekkara, Kochi 682041, India.
authors.forename: Sabarish
authors.initials: S
authors.lastname: Balachandran
authors.affiliation: Department of Microbiology, Amrita Institute of Medical Sciences and Research Centre, Ponekkara, Kochi 682041, India.
authors.forename: Anil
authors.initials: A
authors.lastname: Kumar
authors.affiliation: Department of Pathology, Amrita Institute of Medical Sciences and Research Centre, Ponekkara, Kochi 682041, India.
authors.forename: Bindu
authors.initials: B
authors.lastname: Mangalath Rajamma
authors.affiliation: Department of Neurosurgery, Amrita Institute of Medical Sciences and Research Centre, Ponekkara, Kochi 682041, India.
authors.forename: Ashok
authors.initials: A
authors.lastname: Pillai
authors.affiliation: Department of General Medicine, Amrita Institute of Medical Sciences and Research Centre, Ponekkara, Kochi 682041, India.
authors.forename: Vidya P
authors.initials: VP
authors.lastname: Menon
keywords: CNS Aspergillosis; CNS infections in immunocompromised; Mycobacterium tuberculosis; Spinal Aspergillosis