title: SERUM LEPTIN LEVENS AND HEPATOCELLULAR CARCINOMA: REVIEW ARTICLE.
abstract: Hepatocellular carcinoma is one of the most frequent types of malignant tumors in the world. There is growing evidence of the relationship between it development and obesity. The mechanism that links obesity to cancer is still not fully understood; however, it is essential to the understanding the adipose tissue in metabolic changes related to obesity and hepatocellular carcinoma.
  
  
  
  To review the influence of serum leptin levels in patients with hepatocelular carcinoma.
  
  
  
  Systematic review of the literature based on the methodology of the Cochrane Institute. The search for articles was in the database: Science Direct, Scielo, Medline, Lilacs e Pubmed. The key words used were hepatocellular carcinoma, leptin, adipokine.
  
  
  
  After evaluation of individual studies, were selected seven studies. The results previously studied are still inconsistent and contradictory, and leptin can be effectively involved in the occurrence and development of hepatocellular carcinoma.
  
  
  
  Therefore, it is necessary to develop prospective, well-designed and conducted focusing on the role and specific mechanisms of this hormone in patients with hepatocellular carcinoma, so that new correlations can be properly supported.
authors.affiliation: Postgraduate Program in Nutrition and Oncology, Institute of Education and Research, Moinhos de Vento Hospital.
authors.forename: Luiza Vitelo
authors.initials: LV
authors.lastname: Andrighetto
authors.affiliation: Postgraduate Program in Science in Gastroenterology and Hepatology, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Aline Kirjner
authors.initials: AK
authors.lastname: Poziomyck
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000097:blood*; D006801:Humans; D020738:Leptin / Q000097:blood*; D008113:Liver Neoplasms / Q000097:blood*
chemical_list: D020738:Leptin