title: Failure of Bone Marrow Stimulation Techniques.
abstract: Marrow stimulation techniques, including microfracture, are among the most commonly performed cartilage restoration procedures for symptomatic chondral defects of the knee. For the vast majority of patients, marrow stimulation results in reduced pain and improved function, providing overall satisfactory outcomes. In some cases, however, marrow stimulation fails, resulting in symptom recurrence and often, the need for repeat surgery. This review will describe the indications and outcomes of microfracture as a primary surgical treatment for focal chondral defects of the knee, identify patient and procedure-specific factors associated with poor clinical outcomes, and will discuss treatment options and their respective outcomes for patients with a failed prior microfracture surgery.
authors.affiliation: *Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL †El-Hadara University Hospital, Alexandria University, Alexandria, Egypt.
authors.forename: Rachel M
authors.initials: RM
authors.lastname: Frank
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Cotter
authors.forename: Islam
authors.initials: I
authors.lastname: Nassar
authors.forename: Brian
authors.initials: B
authors.lastname: Cole
mesh_terms: D054544:Arthroplasty, Subchondral / Q000379:methods*; D002358:Cartilage, Articular / Q000293:injuries*; D012090:Cumulative Trauma Disorders / Q000601:surgery*; D006801:Humans; D007718:Knee Injuries / Q000601:surgery*; D012086:Reoperation / Q000379:methods*; D017211:Treatment Failure