title: MicroRNAs and the metabolic hallmarks of aging.
abstract: Aging, the natural process of growing older, is characterized by a progressive deterioration of physiological homeostasis at the cellular, tissue, and organismal level. Metabolically, the aging process is characterized by extensive changes in body composition, multi-tissue/multi-organ insulin resistance, and physiological declines in multiple signaling pathways including growth hormone, insulin/insulin-like growth factor 1, and sex steroids regulation. With this review, we intend to consolidate published information about microRNAs that regulate critical metabolic processes relevant to aging. In certain occasions we uncover relationships likely relevant to aging, which has not been directly described before, such as the miR-451/AMPK axis. We have also included a provocative section highlighting the potential role in aging of a new designation of miRNAs, namely fecal miRNAs, recently discovered to regulate intestinal microbiota in mammals.
authors.affiliation: Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, 6900 Lake Nona Blvd., Orlando, FL 32827, USA. Electronic address: Berta.VictoriaMartinez@ucf.edu.
authors.forename: Berta
authors.initials: B
authors.lastname: Victoria
authors.affiliation: Translational Research Institute for Metabolism & Diabetes. Florida Hospital, 301 East Princeton St, Orlando, FL 32804, USA. Electronic address: Yury.Nunez-Lopez@flhosp.org.
authors.forename: Yury O
authors.initials: YO
authors.lastname: Nunez Lopez
authors.affiliation: Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, 6900 Lake Nona Blvd., Orlando, FL 32827, USA; Department of Head and Neck Surgery, The Greater Poland Cancer Centre, 15 Garbary St., 61-866, Poznan, Poland. Electronic address: Michal.Masternak@ucf.edu.
authors.forename: Michal M
authors.initials: MM
authors.lastname: Masternak
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000235:genetics* / Q000378:metabolism; D000375:Aging / Q000235:genetics* / Q000378:metabolism; D000818:Animals; D001823:Body Composition / Q000235:genetics*; D000069196:Gastrointestinal Microbiome / Q000235:genetics; D018507:Gene Expression Regulation, Developmental; D012739:Gonadal Steroid Hormones / Q000235:genetics / Q000378:metabolism; D013006:Growth Hormone / Q000235:genetics / Q000378:metabolism; D006706:Homeostasis / Q000235:genetics; D006801:Humans; D007328:Insulin / Q000235:genetics / Q000378:metabolism; D007333:Insulin Resistance / Q000235:genetics*; D007334:Insulin-Like Growth Factor I / Q000235:genetics / Q000378:metabolism; D035683:MicroRNAs / Q000145:classification / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction; D013559:Symbiosis / Q000235:genetics*
chemical_list: D012739:Gonadal Steroid Hormones; C583557:IGF1 protein, human; D007328:Insulin; D035683:MicroRNAs; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone; D055372:AMP-Activated Protein Kinases
keywords: Aging; Inflammation; Metabolism; Microbiome; Mitochondria; miRNA