title: From HCV To HBV Cure.
abstract: Approximately 170 million people are chronically infected with HCV and 350 million are chronically infected with HBV worldwide. It is estimated that more than one million patients die from complications related to chronic viral hepatitis, mainly HCC which is one of the most frequent cancers in many countries, especially Africa, the Middle East and Asia. HCV drug development has been impressive, and this revolution led to several direct-acting antiviral agents achieving an HCV cure after only 6-12 weeks. This progress could theorically lead to HCV global elimination making HCV and its consequences a rarity. HBV research and development programs can learn from the HCV experience, to achieve an HBV functional or sterilizing cure. This review will summarize key steps which have been realized for an HCV cure, and discuss the next steps to achieve for an HCV elimination. And also, how this HCV revolution has inspired scientists and clinicians to achieve the same for HBV.
authors.affiliation: Frances Winship Walters Professor of Pediatrics, Center for AIDS Research, Emory University School of Medicine, Atlanta, GA, USA.
authors.forename: Raymond F
authors.initials: RF
authors.lastname: Schinazi
authors.affiliation: Hepatology Department, UMR1149, Physiopathology and Treatment of Viral Hepatitis, Centre de Recherche sur l'Inflammation and Université Denis Diderot Paris 7, Beaujon Hospital, AP-HP, Clichy, France.
authors.forename: Tarik
authors.initials: T
authors.lastname: Asselah
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology*; D006528:Carcinoma, Hepatocellular / Q000209:etiology; D002986:Clinical Trials as Topic; D015195:Drug Design; D016174:Hepacivirus / Q000235:genetics / Q000502:physiology; D006515:Hepatitis B virus / Q000235:genetics / Q000502:physiology; D019694:Hepatitis B, Chronic / Q000150:complications / Q000188:drug therapy*; D019698:Hepatitis C, Chronic / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008113:Liver Neoplasms / Q000209:etiology; D000072230:Sustained Virologic Response; D014779:Virus Replication
chemical_list: D000998:Antiviral Agents
keywords: HBV cure; HCV elimination; capsid inhibitors; cccDNA; direct-acting antivirals