title: The Clinical High-Risk State for Psychosis (CHR-P), Version II.
abstract: The Clinical High-Risk state for psychosis (CHR-P) paradigm was introduced about 2 decades ago. Over this period of time accumulating knowledge has been gained. Conceptual advancements involve new knowledge into risk enrichment and the impact of recruitment strategies, specificity for prediction of psychotic and nonpsychotic mental disorders and heterogeneity of psychosis risk among the different CHR-P subgroups. The current special issue advances current knowledge on deconstructing the CHR-P paradigm across its 3 subgroups: genetic risk, attenuated psychotic symptoms, and short-lived and remitting psychotic episodes. A conceptual revision of the paradigm (Version II) is suggested and supported by 3 original studies published in this special issue.
authors.affiliation: Department of Psychosis Studies, Institute of Psychiatry , Psychology and Neuroscience, King's College London, London, UK; paolo.fusar-poli@kcl.ac.uk.|OASIS Service, South London and the Maudsley NHS Foundation Trust, London, UK.
authors.forename: Paolo
authors.initials: P
authors.lastname: Fusar-Poli
mesh_terms: D006801:Humans; D017410:Practice Guidelines as Topic; D011618:Psychotic Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D018570:Risk Assessment; D012559:Schizophrenia / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology
keywords: ARMS; SIPS; UHR; psychosis; risk; schizophrenia