title: Tackling guanidinoacetic acid for advanced cellular bioenergetics.
abstract: Tissues with high-energy output, such as the brain and skeletal muscle, suffer the most from impaired or depleted energy levels, with innovative nutritional approaches needed to effectively tackle metabolic deficits in bioenergetics. Here, we highlight the role of guanidinoacetic acid in the control and provision of cellular energy by its interaction with cellular transporters for taurine (SLC6 A6) and γ-aminobutyric acid (SLC6 A13), previously dismissed as "untargetable" carriers by other bioenergetics therapeutics.
authors.affiliation: Faculty of Sport and Physical Education, University of Novi Sad, Novi Sad, Serbia; University of Belgrade School of Medicine, Belgrade, Serbia. Electronic address: Sergej.ostojic@chess.edu.rs.
authors.forename: Sergej M
authors.initials: SM
authors.lastname: Ostojic
mesh_terms: D003401:Creatine / Q000378:metabolism; D004734:Energy Metabolism / Q000187:drug effects*; D050485:GABA Plasma Membrane Transport Proteins / Q000235:genetics / Q000378:metabolism; D005998:Glycine / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics / Q000378:metabolism; D026901:Membrane Transport Proteins / Q000235:genetics / Q000378:metabolism; D000099247:Taurine Transporters
chemical_list: D003401:Creatine; D050485:GABA Plasma Membrane Transport Proteins; D005998:Glycine; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D000099247:Taurine Transporters; C493418:SLC6A13 protein, human; C004946:glycocyamine
keywords: Bioenergetics; Creatine; Guanidinoacetic acid; SLC6 A13; SLC6 A6