title: Factors related to pregnancy and birth and the risk of childhood brain tumours: The ESTELLE and ESCALE studies (SFCE, France).
abstract: Little is known of the causes of childhood brain tumors (CBT). The aims of this study were to investigate whether extremes of birth weight were associated with increased risk of CBT and whether maternal preconceptional folic acid supplementation or breastfeeding reduced the risk. In addition, other maternal characteristics and birth related factors were also investigated. We pooled data from two French national population-based case-control studies with similar designs conducted in 2003-2004 and 2010-2011. The mothers of 510 CBT cases (directly recruited from the national childhood cancer register) and 3,102 controls aged under 15 years, frequency matched by age and gender did a telephone interview, which focussed on demographic and perinatal characteristics, and maternal life style habits and reproductive history. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using unconditional logistic regression, adjusted for age, sex, study of origin and relevant confounders. No association was found between CBT and birth weight or fetal growth. The use of preconceptional folic acid supplementation was rare (5.3% in cases and 7.8% in controls) and the OR was 0.8 (95% CI 0.5, 1.4). There was no association with breastfeeding, even prolonged (six months or more; OR 1.0, 95% CI 0.8, 1.4). Neither was there any association between CBT and other investigated factors (maternal body mass index, gestational weight gain, congenital abnormality, maternal reproductive history or use of fertility treatments. Although large, this study was underpowered for subtype analyses. Pooling data with other population-based studies may provide further insight into findings by CBT subtypes.
authors.affiliation: INSERM, Université Paris-Descartes, Université Sorbonne-Paris-Cité, CRESS-EPICEA Epidémiologie des cancers de l'enfant et de l'adolescent, Paris, France.
authors.forename: Helen D
authors.initials: HD
authors.lastname: Bailey
authors.affiliation: INSERM, Université Paris-Descartes, Université Sorbonne-Paris-Cité, CRESS-EPICEA Epidémiologie des cancers de l'enfant et de l'adolescent, Paris, France.
authors.forename: Paula
authors.initials: P
authors.lastname: Rios
authors.affiliation: INSERM, Université Paris-Descartes, Université Sorbonne-Paris-Cité, CRESS-EPICEA Epidémiologie des cancers de l'enfant et de l'adolescent, Paris, France.|RNCE - National Registry of Childhood Cancers, Inserm, Villejuif and CHU de Nancy, France.
authors.forename: Brigitte
authors.initials: B
authors.lastname: Lacour
authors.affiliation: Département de cancérologie de l'enfant et de l'adolescent, Gustave Roussy, Villejuif, France.
authors.forename: Léa
authors.initials: L
authors.lastname: Guerrini-Rousseau
authors.affiliation: Pôle Pédiatrique, Unité d' Hémato-Immuno-Oncologie pédiatrique, CHU, Toulouse, France.
authors.forename: Anne-Isabelle
authors.initials: AI
authors.lastname: Bertozzi
authors.affiliation: Pediatric Oncology Unit, Oscar Lambret Comprehensive Cancer Center, Lille, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Leblond
authors.affiliation: Institut d'hématologie et d'oncologie pédiatrique, IHOPe, Centre Léon Bérard, Lyon, France.
authors.forename: Cécile
authors.initials: C
authors.lastname: Faure-Conter
authors.affiliation: Hématologie Oncologie et Immunologie pédiatrique, Inserm UMR U1232, CHU d'Angers, Angers, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Pellier
authors.affiliation: Clinique de pédiatrie, Hôpital Couple Enfant, CHU Grenoble-Alpes, Grenoble, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Freycon
authors.affiliation: Département de Pédiatrie -Adolescents et Jeunes Adultes, Institut Curie, Paris, France.
authors.forename: Jean
authors.initials: J
authors.lastname: Michon
authors.affiliation: Service de neurochirurgie pédiatrique, Hôpital Necker-Enfants malades, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Puget
authors.affiliation: Service d'onco-hématologie pédiatrique, Hôpital Pellegrin Tripode, Bordeaux, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Ducassou
authors.affiliation: INSERM, Université Paris-Descartes, Université Sorbonne-Paris-Cité, CRESS-EPICEA Epidémiologie des cancers de l'enfant et de l'adolescent, Paris, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Orsi
authors.affiliation: INSERM, Université Paris-Descartes, Université Sorbonne-Paris-Cité, CRESS-EPICEA Epidémiologie des cancers de l'enfant et de l'adolescent, Paris, France.|RNCE - National Registry of Childhood Cancers, Inserm, Villejuif and CHU de Nancy, France.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Clavel
mesh_terms: D000293:Adolescent; D000328:Adult; D001724:Birth Weight; D015992:Body Mass Index; D001932:Brain Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology*; D001942:Breast Feeding; D016022:Case-Control Studies; D002648:Child; D005260:Female; D005602:France; D006801:Humans; D016015:Logistic Models; D008297:Male; D009035:Mothers; D011247:Pregnancy; D012307:Risk Factors
keywords: France; brain tumors; case-control study; child; fertility; fetal growth; folic acid supplementation