title: Profiles of Inflammatory Cytokines in the Vitreous Fluid from Patients with Rhegmatogenous Retinal Detachment and Their Correlations with Clinical Features.
abstract: Purpose. To characterize the profiles for inflammatory cytokines in the vitreous fluid from patients with rhegmatogenous retinal detachment (RRD) by comparing those of other vitreoretinal diseases and to analyze the correlation between intravitreal cytokines and clinical features.Materials and Methods. Vitreous fluid was obtained at the time of surgery from 28 RRD eyes. Vitreous fluid was similarly collected from patients with macular hole (MH), epiretinal membrane, proliferative diabetic retinopathy (PDR), and retinal vein occlusion as controls. Twenty-seven cytokines were measured. Intravitreal cytokine profiles in RRD were characterized by comparing these with those in other vitreoretinal diseases. We also analyzed the correlations between vitreous cytokines and clinical features.Results. There were statistical differences in the MCP-1, MIP-1β, and IP-10 between the RRD and MH, while the IL-6 and IL-8 exhibited levels that were between those for the PDR and MH. MIP-1βwas significantly correlated to both the extent and duration of the RRD, while IL-8 was significantly correlated to the extent of the RRD.Conclusions. MCP-1, MIP-1β, and IP-10 may modify the pathologic features of RRD. The levels of these cytokines are related in part to the clinical features and the level of photoreceptor damage.
authors.affiliation: Department of Ophthalmology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
authors.forename: Shizuka
authors.initials: S
authors.lastname: Takahashi
authors.affiliation: Department of Ophthalmology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
authors.forename: Kobu
authors.initials: K
authors.lastname: Adachi
authors.affiliation: Department of Ophthalmology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Suzuki
authors.affiliation: Department of Ophthalmology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
authors.forename: Atsuko
authors.initials: A
authors.lastname: Maeno
authors.affiliation: Department of Ophthalmology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
authors.forename: Mitsuru
authors.identifier: 0000-0001-6095-5712
authors.initials: M
authors.lastname: Nakazawa
mesh_terms: D000368:Aged; D016207:Cytokines / Q000378:metabolism*; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012163:Retinal Detachment / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D014822:Vitreous Body / Q000378:metabolism*
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators