title: Campylobacter jejuni transducer like proteins: Chemotaxis and beyond.
abstract: Chemotaxis, a process that mediates directional motility toward or away from chemical stimuli (chemoeffectors/ligands that can be attractants or repellents) in the environment, plays an important role in the adaptation of Campylobacter jejuni to disparate niches. The chemotaxis system consists of core signal transduction proteins and methyl-accepting-domain-containing Transducer like proteins (Tlps). Ligands binding to Tlps relay a signal to chemotaxis proteins in the cytoplasm which initiate a signal transduction cascade, culminating into a directional flagellar movement. Tlps facilitate substrate-specific chemotaxis in C. jejuni, which plays an important role in the pathogen's adaptation, pathobiology and colonization of the chicken gastrointestinal tract. However, the role of Tlps in C. jejuni's host tissue specific colonization, physiology and virulence remains not completely understood. Based on recent studies, it can be predicted that Tlps might be important targets for developing strategies to control C. jejuni via vaccines and antimicrobials.
authors.affiliation: a Department of Food Animal Health and Preventive Medicine , Ohio Agricultural Research and Development Center, Ohio State University , Wooster , Ohio , USA.
authors.forename: Kshipra
authors.initials: K
authors.lastname: Chandrashekhar
authors.affiliation: a Department of Food Animal Health and Preventive Medicine , Ohio Agricultural Research and Development Center, Ohio State University , Wooster , Ohio , USA.
authors.forename: Issmat I
authors.initials: II
authors.lastname: Kassem
authors.affiliation: a Department of Food Animal Health and Preventive Medicine , Ohio Agricultural Research and Development Center, Ohio State University , Wooster , Ohio , USA.
authors.forename: Gireesh
authors.initials: G
authors.lastname: Rajashekara
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D002169:Campylobacter Infections / Q000382:microbiology / Q000662:veterinary*; D016123:Campylobacter jejuni / Q000235:genetics / Q000502:physiology*; D002633:Chemotaxis; D002645:Chickens; D041981:Gastrointestinal Tract / Q000382:microbiology
chemical_list: D001426:Bacterial Proteins
keywords: Tlps; adaptation; amino acids; biofilm; chemotaxis; chicken; colonization; methyl accepting chemoreceptors; motility; organic acids; virulence