title: Effectiveness of Combined Therapy with Pirfenidone and Erythromycin for Unclassifiable Interstitial Pneumonia Induced by HTLV-1-associated Bronchioloalveolar Disorder (HABA).
abstract: Human T-cell lymphotropic virus type 1 (HTLV-1) is a retrovirus involved in the pathogenesis of adult T-cell leukemia (ATL) and HTVL-1-associated bronchioloalveolar disorder (HABA). The clinical and pathological findings of HABA have been characterized as either a diffuse panbronchiolitis (DPB) pattern or idiopathic interstitial pneumonia (IIP) pattern. Treatments for HABA include corticosteroids for the IIP pattern and erythromycin for the DPB pattern. We herein report a case of HABA-associated unclassifiable interstitial pneumonia that improved with combined therapy with pirfenidone and erythromycin. This is the first report on the effectiveness of combined therapy with pirfenidone and erythromycin for HABA.
authors.affiliation: Division of Respiratory Medicine, Tokyo Women's Medical University Yachiyo Medical Center, Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Yokohori
authors.forename: Akitoshi
authors.initials: A
authors.lastname: Sato
authors.forename: Mizue
authors.initials: M
authors.lastname: Hasegawa
authors.forename: Hideki
authors.initials: H
authors.lastname: Katsura
authors.forename: Kenzo
authors.initials: K
authors.lastname: Hiroshima
authors.forename: Tamiko
authors.initials: T
authors.lastname: Takemura
mesh_terms: D000368:Aged; D001982:Bronchial Diseases / Q000175:diagnosis*; D001988:Bronchiolitis / Q000473:pathology; D004338:Drug Combinations; D004917:Erythromycin / Q000627:therapeutic use*; D006192:Haemophilus Infections / Q000473:pathology; D015368:Human T-lymphotropic virus 1 / Q000472:pathogenicity; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000473:pathology; D017563:Lung Diseases, Interstitial / Q000175:diagnosis* / Q000188:drug therapy* / Q000821:virology; D008297:Male; D011728:Pyridones / Q000627:therapeutic use*
chemical_list: D004338:Drug Combinations; D011728:Pyridones; D004917:Erythromycin; C093844:pirfenidone