title: Microvasculature remodeling in the mouse lower gut during inflammaging.
abstract: Inflammaging is defined as low-grade, chronic, systemic inflammation in aging, in the absence of overt infection. Age-associated deterioration of gastrointestinal function could be ascribed to the inflammaging, although evidence is yet to emerge. Here we show that microvessels in aging mouse intestine were progressively deprived of supportive structures, microvessel-associated pericytes and adherens junction protein vascular endothelial (VE)-cadherin, and became leaky. This alteration was ascribed to up-regulation of angiopoetin-2 in microvascular endothelial cells. Up-regulation of the angiopoietin-2 was by TNF-α, originated from M2-like residential CD206+macrophages, proportion of which increases as animal ages. It was concluded that antigenic burdens encountered in intestine throughout life create the condition of chronic stage of inflammation, which accumulates M2-like macrophages expressing TNF-α. The TNF-α induces vascular leakage to facilitate recruitment of immune cells into intestine under the chronic inflammatory setting.
authors.affiliation: Department of Microbiology, Chonnam National University Medical School, Republic of Korea.|Department of Molecular Medicine(BK21plus), Chonnam National University Graduate School, Republic of Korea.
authors.forename: Jae-Ho
authors.initials: JH
authors.lastname: Jeong
authors.affiliation: Department of Microbiology, Chonnam National University Medical School, Republic of Korea.|Department of Molecular Medicine(BK21plus), Chonnam National University Graduate School, Republic of Korea.
authors.forename: KwangSoo
authors.initials: K
authors.lastname: Kim
authors.affiliation: Department of Microbiology, Chonnam National University Medical School, Republic of Korea.|Department of Molecular Medicine(BK21plus), Chonnam National University Graduate School, Republic of Korea.
authors.forename: Daejin
authors.initials: D
authors.lastname: Lim
authors.affiliation: Department of Microbiology, Chonnam National University Medical School, Republic of Korea.|Department of Molecular Medicine(BK21plus), Chonnam National University Graduate School, Republic of Korea.
authors.forename: Kun-Hee
authors.initials: KH
authors.lastname: Kim
authors.affiliation: Department of Forensic Medicine, Chonnam National University Medical School, Republic of Korea.
authors.forename: Hyung-Seok
authors.initials: HS
authors.lastname: Kim
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Chonnam National University Hospital, Gwangju, Republic of Korea.
authors.forename: Sungsu
authors.initials: S
authors.lastname: Lee
authors.affiliation: Well Aging Research Center, SAIT. Suwon, Gyeonggido, Republic of Korea.
authors.forename: Joo-Hye
authors.initials: JH
authors.lastname: Song
authors.affiliation: Well Aging Research Center, SAIT. Suwon, Gyeonggido, Republic of Korea.
authors.forename: Byoung-Gon
authors.initials: BG
authors.lastname: Moon
authors.affiliation: Department of Microbiology, Chonnam National University Medical School, Republic of Korea.|Department of Molecular Medicine(BK21plus), Chonnam National University Graduate School, Republic of Korea.
authors.forename: Hyon E
authors.initials: HE
authors.lastname: Choy
authors.affiliation: Well Aging Research Center, SAIT. Suwon, Gyeonggido, Republic of Korea.|Department of New Biology, Well Aging Research Center, DGIST, Daegu, Republic of Korea.
authors.forename: Sang Chul
authors.initials: SC
authors.lastname: Park
mesh_terms: D022005:Adherens Junctions / Q000378:metabolism; D000375:Aging / Q000473:pathology*; D042702:Angiopoietin-2 / Q000378:metabolism; D000818:Animals; D015820:Cadherins / Q000378:metabolism; D005260:Female; D061307:Human Umbilical Vein Endothelial Cells / Q000378:metabolism; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism*; D007422:Intestines / Q000166:cytology / Q000254:growth & development; D037181:Lectins, C-Type / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D055806:Microvessels / Q000166:cytology / Q000254:growth & development / Q000378:metabolism*; D020286:Pericytes / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D066253:Vascular Remodeling
chemical_list: D042702:Angiopoietin-2; D015820:Cadherins; D037181:Lectins, C-Type; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins; D011956:Receptors, Cell Surface; D014409:Tumor Necrosis Factor-alpha