title: Early Evaluation and Monitoring of Critical Patients with Acute Respiratory Distress Syndrome (ARDS) Using Specific Genetic Polymorphisms.
abstract: A high percentage of critical patients are found to develop acute respiratory distress syndrome (ARDS). Several studies have reported high mortality rates in these cases which are most frequently associated with multiple organ dysfunctions syndrome. Lately, many efforts have been made to evaluate and monitor ARDS in critical patients. In this regard, the assessment of genetic polymorphisms responsible for developing ARDS present as a challenge and are considered future biomarkers. Early detection of the specific polymorphic gene responsible for ARDS in critically ill patients can prove to be a useful tool in the future, able to help decrease the mortality rates in these cases. Moreover, identifying the genetic polymorphism in these patients can help in the implementation of a personalized intensive therapy scheme for every type of patient, based on its genotype.
authors.affiliation: Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
authors.forename: Florin G
authors.initials: FG
authors.lastname: Horhat
authors.affiliation: Faculty of Medicine, Ataturk University, Erzurum, Turkey.
authors.forename: Fuat
authors.initials: F
authors.lastname: Gundogdu
authors.affiliation: Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
authors.forename: Laurentiu V
authors.initials: LV
authors.lastname: David
authors.affiliation: Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
authors.forename: Eugen S
authors.initials: ES
authors.lastname: Boia
authors.affiliation: Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
authors.forename: Laurentiu
authors.initials: L
authors.lastname: Pirtea
authors.affiliation: Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
authors.forename: Razvan
authors.initials: R
authors.lastname: Horhat
authors.affiliation: Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
authors.forename: Alexandru
authors.initials: A
authors.lastname: Cucui-Cozma
authors.affiliation: Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
authors.forename: Ioana
authors.initials: I
authors.lastname: Ciuca
authors.affiliation: Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
authors.forename: Mircea
authors.initials: M
authors.lastname: Diaconu
authors.affiliation: Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
authors.forename: Razvan
authors.initials: R
authors.lastname: Nitu
authors.affiliation: Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
authors.forename: Monica
authors.initials: M
authors.lastname: Licker
authors.affiliation: Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
authors.forename: Delia I
authors.initials: DI
authors.lastname: Horhat
authors.affiliation: Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania. alexandru.rogobete@umft.ro.|Clinic of Anaesthesia and Intensive Care, Emergency County Hospital "Pius Brinzeu", Timisoara, Romania. alexandru.rogobete@umft.ro.
authors.forename: Alexandru F
authors.identifier: http://orcid.org/0000-0003-1286-4431
authors.initials: AF
authors.lastname: Rogobete
authors.affiliation: Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
authors.forename: Marius L
authors.initials: ML
authors.lastname: Moise
authors.affiliation: Faculty of Medicine, "Carol Davila" University of Medicine, Bucharest, Romania.
authors.forename: Calin
authors.initials: C
authors.lastname: Tataru
mesh_terms: D015415:Biomarkers / Q000032:analysis*; D016638:Critical Illness; D042241:Early Diagnosis; D005069:Evaluation Studies as Topic; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*; D012128:Respiratory Distress Syndrome / Q000175:diagnosis* / Q000235:genetics
chemical_list: D015415:Biomarkers
keywords: Acute respiratory distress syndrome; Critically ill patients; Polymorphisms; Sepsis