title: Left ventricular filling pressure by septal and lateral E/e' equally predict cardiovascular events in the general population.
abstract: OBJECTIVE
  There exists no consensus on the site of E/e' measurement. This study aimed to evaluate the predictive value of septal and lateral E/e' along with the importance of their intra-individual difference.
  
  
  METHODS
  In 1775 persons from the general population, peak early diastolic velocity (e') was obtained by color tissue Doppler at the septal and lateral mitral annular sites. The endpoint was combined of cardiovascular death or admission due to heart failure or acute myocardial infarction.
  
  
  RESULTS
  During a median follow-up of 10.9 years, the endpoint occurred in 227 participants. E/e'septaland E/e'lateralwere equally strong predictors of cardiac events; in age- and sex-adjusted models they did not differ in AUC (septal: 0.8385, lateral: 0.8389; p = 0.94) or in continuous NRI (p = 0.84). Models using E/e'averagedid not improve AUC or NRI, and the intra-individual difference between sites had no predictive value (p = 0.79). E/e'septalwas generally higher than E/e'lateral, thus age- and sex-specific normal values were reported for both sites for a population free of cardiac events during 10 years of follow-up.
  
  
  CONCLUSIONS
  Septal and lateral E/e' are equally useful in predicting cardiac events in the general population. Measuring both sites provides no further predictive value than measuring a single site.
authors.affiliation: Copenhagen City Heart Study, Frederiksberg Hospital, University of Copenhagen, Frederiksberg, Denmark. joanna.nan.wang@gmail.com.|Department of Cardiology, Herlev and Gentofte Hospital, University of Copenhagen, Post 835, Kildegaardsvej 28, 2900, Hellerup, Denmark. joanna.nan.wang@gmail.com.
authors.forename: Joanna Nan
authors.initials: JN
authors.lastname: Wang
authors.affiliation: Copenhagen City Heart Study, Frederiksberg Hospital, University of Copenhagen, Frederiksberg, Denmark.|Department of Cardiology, Herlev and Gentofte Hospital, University of Copenhagen, Post 835, Kildegaardsvej 28, 2900, Hellerup, Denmark.
authors.forename: Tor
authors.initials: T
authors.lastname: Biering-Sørensen
authors.affiliation: Copenhagen City Heart Study, Frederiksberg Hospital, University of Copenhagen, Frederiksberg, Denmark.|Department of Cardiology, Herlev and Gentofte Hospital, University of Copenhagen, Post 835, Kildegaardsvej 28, 2900, Hellerup, Denmark.
authors.forename: Peter Godsk
authors.initials: PG
authors.lastname: Jørgensen
authors.affiliation: Copenhagen City Heart Study, Frederiksberg Hospital, University of Copenhagen, Frederiksberg, Denmark.|Department of Cardiology, Herlev and Gentofte Hospital, University of Copenhagen, Post 835, Kildegaardsvej 28, 2900, Hellerup, Denmark.|Faculty of Health Sciences, Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Jan Skov
authors.initials: JS
authors.lastname: Jensen
authors.affiliation: Copenhagen City Heart Study, Frederiksberg Hospital, University of Copenhagen, Frederiksberg, Denmark.|Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Rasmus
authors.initials: R
authors.lastname: Mogelvang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019540:Area Under Curve; D002318:Cardiovascular Diseases / Q000000981:diagnostic imaging* / Q000401:mortality / Q000503:physiopathology / Q000628:therapy; D018450:Disease Progression; D018572:Disease-Free Survival; D018618:Echocardiography, Doppler, Color; D005260:Female; D006333:Heart Failure / Q000000981:diagnostic imaging / Q000401:mortality / Q000503:physiopathology; D006346:Heart Septum / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006760:Hospitalization; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000000981:diagnostic imaging* / Q000503:physiopathology; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000401:mortality / Q000503:physiopathology; D011237:Predictive Value of Tests; D012372:ROC Curve; D013997:Time Factors; D016277:Ventricular Function, Left; D017725:Ventricular Pressure; D055815:Young Adult
keywords: Echocardiography; General population; Normal values; Prognosis; Tissue Doppler