title: Arterial Stiffness in Aortic Stenosis: Relationship with Severity and Echocardiographic Procedures Response.
abstract: BACKGROUND
  Aortic stenosis (AS) is more than only a degenerative disease, it could be also an atherosclerotic-like process involving the valve instead of the vessels. Little is known about the relation of arterial stiffness and AS.
  
  
  OBJECTIVE
  We sought to determine wether pulse wave velocity (PWV), is related to AS severity and to the procedures response, both as surgical aortic-valve-replacement (AVR) and trascatheter-aortic-valve-implantation (TAVI).
  
  
  METHODS
  30 patients with severe AS were treated (15 AVR, 15 TAVI). Before the procedures (t0) and after 1 week (t1) echocardiography and PWV were evaluated.
  
  
  RESULTS
  On the whole population, subjects with higher PWV showed higher transvalvular pressure gradient at baseline (mean: 56.5 ± 15.1 vs 45.4 ± 9.5; peak: 93.3 ± 26.4 vs 73.3 ± 14.9, p = 0.02) and, a significantly greater response to the procedures (mean: -42.9 ± 17.2 vs -27.9 ± 10.1, peak: -68.7 ± 29.2 vs -42.8 ± 16.4, p = 0.02). When the two different procedures groups were separated, data were confirmed only in the TAVI subgroup.
  
  
  CONCLUSIONS
  In patients undergoing procedures for AS, PWV is correlated with transvalvular gradient and, in TAVI subjects, is able to predict the echocardiographic response. Baseline evaluation of PWV in patients candidates to TAVI can help the selection of subjects, even if larger and longer studies are needed before definitive conclusion can be drawn.
authors.affiliation: Cardiology I, "A.De Gasperis" Department, Niguarda Ca Granda Hospital, Milan, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Bruschi
authors.affiliation: Health Science Department, Milano-Bicocca University, Milan, Italy.|Cardiologia IV, Dipartimento A.De Gasperis, Ospedale Niguarda Ca Granda, Piazza Ospedale Maggiore 3, 20159, Milan, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Maloberti
authors.affiliation: Health Science Department, Milano-Bicocca University, Milan, Italy.|Cardiologia IV, Dipartimento A.De Gasperis, Ospedale Niguarda Ca Granda, Piazza Ospedale Maggiore 3, 20159, Milan, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Sormani
authors.affiliation: Health Science Department, Milano-Bicocca University, Milan, Italy.|Cardiologia IV, Dipartimento A.De Gasperis, Ospedale Niguarda Ca Granda, Piazza Ospedale Maggiore 3, 20159, Milan, Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: Colombo
authors.affiliation: Cardiology I, "A.De Gasperis" Department, Niguarda Ca Granda Hospital, Milan, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Nava
authors.affiliation: Cardiologia IV, Dipartimento A.De Gasperis, Ospedale Niguarda Ca Granda, Piazza Ospedale Maggiore 3, 20159, Milan, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Vallerio
authors.affiliation: Cardiologia IV, Dipartimento A.De Gasperis, Ospedale Niguarda Ca Granda, Piazza Ospedale Maggiore 3, 20159, Milan, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Casadei
authors.affiliation: Health Science Department, Milano-Bicocca University, Milan, Italy.
authors.forename: Jolie
authors.initials: J
authors.lastname: Bruno
authors.affiliation: Cardiologia IV, Dipartimento A.De Gasperis, Ospedale Niguarda Ca Granda, Piazza Ospedale Maggiore 3, 20159, Milan, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Moreo
authors.affiliation: Cardiosurgery, "A.De Gasperis" Department, Niguarda Ca Granda Hospital, Milan, Italy.
authors.forename: Bruno
authors.initials: B
authors.lastname: Merlanti
authors.affiliation: Cardiosurgery, "A.De Gasperis" Department, Niguarda Ca Granda Hospital, Milan, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Russo
authors.affiliation: Cardiology I, "A.De Gasperis" Department, Niguarda Ca Granda Hospital, Milan, Italy.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Oliva
authors.affiliation: Cardiology I, "A.De Gasperis" Department, Niguarda Ca Granda Hospital, Milan, Italy.
authors.forename: Silvio
authors.initials: S
authors.lastname: Klugmann
authors.affiliation: Health Science Department, Milano-Bicocca University, Milan, Italy. cristina.giannattasio@unimib.it.|Cardiologia IV, Dipartimento A.De Gasperis, Ospedale Niguarda Ca Granda, Piazza Ospedale Maggiore 3, 20159, Milan, Italy. cristina.giannattasio@unimib.it.
authors.forename: Cristina
authors.initials: C
authors.lastname: Giannattasio
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001011:Aorta / Q000000981:diagnostic imaging* / Q000503:physiopathology; D001021:Aortic Valve / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000601:surgery; D001024:Aortic Valve Stenosis / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000601:surgery; D015150:Echocardiography, Doppler; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008297:Male; D018579:Patient Selection; D011237:Predictive Value of Tests; D063177:Pulse Wave Analysis; D020127:Recovery of Function; D012720:Severity of Illness Index; D013997:Time Factors; D065467:Transcatheter Aortic Valve Replacement; D016896:Treatment Outcome; D059289:Vascular Stiffness
keywords: Aortic stenosis; Aortic valve replacement; Arterial stiffness; Pulse wave velocity; Transcatheter aortic valve implantation