title: Magnesium Sulfate: Another Cause of a Solute Diuresis.
abstract: In pregnant women, magnesium sulfate infusions are a treatment commonly used for preeclampsia and as a tocolytic agent. In this case report, a 33-year-old woman at 26 weeks of gestation received intravenous magnesium sulfate in Ringer's lactate solution and corticosteroids for preterm uterine contractions without preeclampsia. She developed polyuria of more than 18L in 48 hours, with urine chemistries documenting that magnesium sulfate contributed 30% of the solute in this massive isosthenuric diuresis. Therefore, magnesium sulfate should be added to the common solutes, glucose, sodium chloride, urea, and mannitol, as a cause of solute diureses.
authors.affiliation: Division of Nephrology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA. Electronic address: rbrown@bidmc.harvard.edu.
authors.forename: Robert S
authors.initials: RS
authors.lastname: Brown
mesh_terms: D000328:Adult; D001623:Betamethasone / Q000008:administration & dosage; D004231:Diuresis / Q000187:drug effects*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007273:Injections, Intramuscular; D007552:Isotonic Solutions / Q000008:administration & dosage* / Q000009:adverse effects*; D008278:Magnesium Sulfate / Q000008:administration & dosage* / Q000009:adverse effects*; D007752:Obstetric Labor, Premature / Q000188:drug therapy*; D011141:Polyuria / Q000139:chemically induced* / Q000503:physiopathology*; D011247:Pregnancy; D012008:Recurrence; D000077325:Ringer's Lactate
chemical_list: D007552:Isotonic Solutions; D000077325:Ringer's Lactate; D008278:Magnesium Sulfate; D001623:Betamethasone
keywords: Solute diuresis; case report; magnesium sulfate; polyuria; pregnancy; preterm labor; tocolytic agent; urine chemistry; urine output