title: Posterior Reversible Encephalopathy Syndrome and Cerebral Sinus Thrombosis in a Case of Pediatric B-Cell ALL.
abstract: Posterior reversible encephalopathy syndrome (PRES) and cerebral sinus thrombosis are 2 known complications of acute lymphoblastic leukemia and its treatment. We describe a patient with acute lymphoblastic leukemia whose course was complicated by both of these conditions. This case is novel both for the fact that PRES developed before the initiation of therapy and that PRES was followed shortly by the development of cerebral sinus thrombosis. Our patient's story raises questions about our current understanding of the pathophysiology of PRES, and it suggests that PRES may actually be a predisposing risk factor for cerebral sinus thrombosis.
authors.affiliation: *Department of Pediatrics †Division of Hematology/Oncology, Nemours/A.I duPont Hospital for Children at Thomas Jefferson University, Wilmington, DE.
authors.forename: Ellen
authors.initials: E
authors.lastname: Fraint
authors.forename: Robin
authors.initials: R
authors.lastname: Miller
authors.forename: Andrew
authors.initials: A
authors.lastname: Walter
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002545:Brain Ischemia / Q000000981:diagnostic imaging / Q000209:etiology; D002544:Cerebral Infarction / Q000000981:diagnostic imaging / Q000209:etiology; D002675:Child, Preschool; D004656:Enalapril / Q000627:therapeutic use; D017984:Enoxaparin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D019586:Intracranial Hypertension / Q000188:drug therapy / Q000209:etiology; D008279:Magnetic Resonance Imaging; D059906:Neuroimaging; D009778:Occipital Lobe / Q000000981:diagnostic imaging; D010211:Papilledema / Q000209:etiology; D010296:Parietal Lobe / Q000000981:diagnostic imaging; D054038:Posterior Leukoencephalopathy Syndrome / Q000000981:diagnostic imaging / Q000209:etiology*; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000188:drug therapy; D012074:Remission Induction; D012851:Sinus Thrombosis, Intracranial / Q000000981:diagnostic imaging / Q000209:etiology*
chemical_list: D017984:Enoxaparin; D004656:Enalapril