title: Integrating Micro- or Nanoscale Encapsulation Technology with Vitreous Cryopreservation: A New Strategy to Improve Biopreservation.
abstract: BACKGROUND: None-uniform distributions of temperatures, limited freezing and thawing rates, and thermal stresses are three main hindering factors for successful vitreous cryopreservation of mass volume of biosamples. Micro- and nanoscale encapsulation, owning the intrinsic features to avoid those limitations introduced by the traditional approaches, has been opened up a new way for effective and high-efficiency biopreservation.
  This short review article summarizes recent advances in cell encapsulation technology for biopreservation by manipulating cells and biological agents in micro- or nanoscale volume droplets and microgels, and discusses its promising applications for future vitreous cryopreservation.
authors.affiliation: Center for Biomedical Engineering, Department of Electronic Science and Technology, University of Science and Technology of China; Anhui Provincial Engineering Technology Research Center for Biopreservation and Artificial Organs, Hefei, Anhui, China. zhaog@ustc.edu.cn.
authors.forename: Y Y
authors.initials: YY
authors.lastname: Zheng
authors.affiliation: Center for Biomedical Engineering, Department of Electronic Science and Technology, University of Science and Technology of China; Anhui Provincial Engineering Technology Research Center for Biopreservation and Artificial Organs, Hefei, Anhui, China. zhaog@ustc.edu.cn.
authors.forename: G
authors.initials: G
authors.lastname: Zhao
mesh_terms: D015925:Cryopreservation / Q000379:methods*; D005615:Freezing; D006801:Humans; D036103:Nanotechnology / Q000379:methods*