title: Characterization of the Iberian Y chromosome haplogroup R-DF27 in Northern Spain.
abstract: The European paternal lineage R-DF27 has been proposed as a haplogroup of Iberian origin due to its maximum frequencies in the Iberian Peninsula. In this study, the distribution and structure of DF27 were characterized in 591 unrelated male individuals from four key populations of the north area of the Iberian Peninsula through the analysis of 12 Y-SNPs that define DF27 main sublineages. Additionally, Y-SNP allele frequencies were also gathered from the reference populations in the 1000 Genomes Project to compare and obtain a better landscape of the distribution of DF27. Our results reveal frequencies over 35% of DF27 haplogroup in the four North Iberian populations analyzed and high frequencies for its subhaplogroups. Considering the low frequency of DF27 and its sublineages in most populations outside of the Iberian Peninsula, this haplogroup seems to have geographical significance; thus, indicating a possible Iberian patrilineal origin of vestiges bearing this haplogroup. The dataset presented here contributes with new data to better understand the complex genetic variability of the Y chromosome in the Iberian Peninsula, that can be applied in Forensic Genetics.
authors.affiliation: BIOMICs Research Group, Lascaray Research Center, University of the Basque Country UPV/EHU, Vitoria-Gasteiz, Spain.
authors.forename: Patricia
authors.initials: P
authors.lastname: Villaescusa
authors.affiliation: BIOMICs Research Group, Lascaray Research Center, University of the Basque Country UPV/EHU, Vitoria-Gasteiz, Spain.
authors.forename: María José
authors.initials: MJ
authors.lastname: Illescas
authors.affiliation: BIOMICs Research Group, Lascaray Research Center, University of the Basque Country UPV/EHU, Vitoria-Gasteiz, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Valverde
authors.affiliation: BIOMICs Research Group, Lascaray Research Center, University of the Basque Country UPV/EHU, Vitoria-Gasteiz, Spain.
authors.forename: Miriam
authors.initials: M
authors.lastname: Baeta
authors.affiliation: BIOMICs Research Group, Lascaray Research Center, University of the Basque Country UPV/EHU, Vitoria-Gasteiz, Spain.
authors.forename: Carolina
authors.initials: C
authors.lastname: Nuñez
authors.affiliation: Laboratory of Genetics and Genetic Identification, University of Zaragoza, Spain.
authors.forename: Begoña
authors.initials: B
authors.lastname: Martínez-Jarreta
authors.affiliation: Unit of Legal Medicine, University of Cantabria, Av. Herrera Oria, s/n, 39011 Santander, Cantabria, Spain; Instituto de Investigación Marqués de Valdecilla (IDIVAL). Avda. Cardenal Herrera Oria s/n, 39011 Santander, Cantabria, Spain.
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Zarrabeitia
authors.affiliation: Departament de Ciències Experimentals i de la Salut, Institute of Evolutionary Biology (CSIC-Universitat Pompeu Fabra), Universitat Pompeu Fabra, CEXS-UPF-PRBB, Barcelona, Catalonia, Spain.
authors.forename: Francesc
authors.initials: F
authors.lastname: Calafell
authors.affiliation: BIOMICs Research Group, Lascaray Research Center, University of the Basque Country UPV/EHU, Vitoria-Gasteiz, Spain. Electronic address: marian.mdepancorbo@ehu.eus.
authors.forename: Marian M
authors.initials: MM
authors.lastname: de Pancorbo
mesh_terms: D041322:Chromosomes, Human, Y; D005787:Gene Frequency; D005828:Genetics, Population; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D013030:Spain
keywords: DF27; Iberia; R haplogroup; Y chromosome; Z195