title: Lactogenic activity ofTeramnus labialis(Linn.) fruit with special reference to the estimation of serum prolactin and cortisol level in nursing rats.
abstract: OBJECTIVE
  The objective of the study was to investigate the lactogenic activity of methanolic extract ofTeramnus labialis(L.) fruit (MTLF) on rats.
  
  
  METHODS
  Nursing rats (200-250 g) with their suckling pups were selected and were divided into five groups (n= 6). Group I treated as control (distil water); Group II treated as standard (domperidone), and Group III, IV, and V were orally administered with MTLF at 200, 400, and 600 mg/kg body weight, respectively and continued for l4thday of parturition. Milk yield, the pups as well as mother's weight were measured daily. On 15thday, the total protein/carbohydrate contents from mammary tissue and serum prolactin/cortisol level from blood sample were measured and compared with control.
  
  
  RESULTS
  Oral administration of MTLF increases the milk yield, body weight of pups as well as mother rat, glycogen, and protein content as well as serum prolactin and cortisol level as compared to the control animals. In addition, the lactogenic effect of MTLF was followed dose-dependent manner as compared to control.
  
  
  CONCLUSIONS
  The present study was revealed that the MTLF possesses significant lactogenic activity by enhancing milk production and prolactin concentration in nursing rats.
authors.affiliation: Department of Pharmacology, MKCG Medical College and Hospital, Berhampur, Odisha, India.
authors.forename: Himanshu Bhusan
authors.initials: HB
authors.lastname: Sahoo
authors.affiliation: Department of Pharmacognosy, Roland Institute of Pharmaceutical Sciences, Berhampur, Odisha, India.
authors.forename: Amrita
authors.initials: A
authors.lastname: Bhaiji
authors.affiliation: Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab, India.
authors.forename: Dev Das
authors.initials: DD
authors.lastname: Santani
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D015415:Biomarkers / Q000097:blood; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D007887:Fabaceae; D005260:Female; D005638:Fruit; D006854:Hydrocortisone / Q000097:blood*; D007774:Lactation / Q000097:blood* / Q000187:drug effects; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D011388:Prolactin / Q000097:blood*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
chemical_list: D015415:Biomarkers; D010936:Plant Extracts; D011388:Prolactin; D006854:Hydrocortisone
keywords: Cortisol; Teramnus labialis; lactogenic; milk yield; serum prolactin