title: Associations between genetic variants in immunoregulatory genes and risk of non-Hodgkin lymphoma in a Chinese population.
abstract: We undertook a hospital-based case-control study to examine the associations between single nucleotide polymorphisms (SNPs) in selected immunoregulatory genes and non-Hodgkin lymphoma (NHL) risk in a Chinese population. One hundred and sixty-nine NHL patients diagnosed according to the World Health Organization (WHO) 2001 standard and 421 controls were recruited. Nine SNPs in three genes (IL-10, IL-1RN, and TNF-α) were selected based on predicted functions and previous study findings. Genetic association analysis was performed using the Cochran-Armitage trend test and multiple logistic regression. Four SNPs were associated with an increased risk of overall NHL: odds ratio per minor allele [ORper-minor-allele] and 95% confidence interval [CI] were 2.64 (1.75-3.98) for IL-10 rs1800893, 2.67 (1.72-4.16) for IL-1RN rs4251961, 1.80 (1.24-2.63) for TNF- α rs1800630, and 1.55 (1.02-2.37) for TNF- α rs2229094. These SNPs were also associated with an increased risk of diffuse large B-cell lymphoma (DLBCL). In addition, another SNP (TNF- α rs1041981) was associated with an increased risk of DLBCL (ORper-minor-allele=1.73, 95% CI 1.14-2.61). The findings provide evidence on the role of these immunoregulatory gene variants in NHL etiology.
authors.affiliation: Department of Community Health Sciences, College of Medicine, Faculty of Health Sciences, University of Manitoba, Canada.|Vaccine and Drug Evaluation Centre, University of Manitoba, Canada.|Centre for Healthcare Innovation, University of Manitoba, Winnipeg, Manitoba, Canada.
authors.forename: Xibiao
authors.initials: X
authors.lastname: Ye
authors.affiliation: Centre for Healthcare Innovation, University of Manitoba, Winnipeg, Manitoba, Canada.|Department of Biochemistry and Medical Genetics, College of Medicine, Faculty of Health Sciences, University of Manitoba, Canada.
authors.forename: Kaiqiong
authors.initials: K
authors.lastname: Zhao
authors.affiliation: School of Public Health, Fudan University, Shanghai, China.
authors.forename: Cuie
authors.initials: C
authors.lastname: Wu
authors.affiliation: Centre for Healthcare Innovation, University of Manitoba, Winnipeg, Manitoba, Canada.|Department of Biochemistry and Medical Genetics, College of Medicine, Faculty of Health Sciences, University of Manitoba, Canada.
authors.forename: Pingzhao
authors.initials: P
authors.lastname: Hu
authors.affiliation: School of Public Health, Fudan University, Shanghai, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Fu
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics; D014408:Biomarkers, Tumor / Q000235:genetics*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002681:China; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000235:genetics*; D016753:Interleukin-10 / Q000235:genetics*; D016015:Logistic Models; D016403:Lymphoma, Large B-Cell, Diffuse / Q000208:ethnology / Q000235:genetics / Q000276:immunology; D008228:Lymphoma, Non-Hodgkin / Q000208:ethnology / Q000235:genetics* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D014408:Biomarkers, Tumor; C508609:IL10 protein, human; C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10
keywords: genetic susceptibility; non-Hodgkin lymphoma; single nucleotide polymorphism