title: Intestinal Enterobacteriaceae that Protect Nematodes from the Effects of Benzimidazoles.
abstract: The objective of this study was to investigate an interaction between nematodes and gut Enterobacteriaceae that use benzimidazoles as a carbon source. By addressing this objective, we identified an anthelmintic resistance-like mechanism for gastrointestinal nematodes. We isolated 30 gut bacteria (family Enterobacteriaceae) that subsist on and putatively catabolize benzimidazole-class anthelmintics.C. eleganswas protected from the effects of benzimidazoles when co-incubated with these Enterobacteriaceae that also protect adult ascarids from the effects of albendazole. This bacterial phenotype represents a novel mechanism by which gastrointestinal nematodes are potentially spared from the effects of benzimidazoles, without any apparent fitness cost to the parasite.
authors.affiliation: Department of Biomedical Sciences, Iowa State University College of Veterinary Medicine, Ames, IA, USA.
authors.forename: John H
authors.initials: JH
authors.lastname: Whittaker
authors.affiliation: Department of Biomedical Sciences, Iowa State University College of Veterinary Medicine, Ames, IA, USA.
authors.forename: Alan P
authors.initials: AP
authors.lastname: Robertson
authors.affiliation: Department of Biomedical Sciences, Iowa State University College of Veterinary Medicine, Ames, IA, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Kimber
authors.affiliation: Department of Biomedical Sciences, Iowa State University College of Veterinary Medicine, Ames, IA, USA.
authors.forename: Tim A
authors.initials: TA
authors.lastname: Day
authors.affiliation: Department of Biomedical Sciences, Iowa State University College of Veterinary Medicine, Ames, IA, USA.
authors.forename: Steve A
authors.initials: SA
authors.lastname: Carlson
keywords: Anthelmintic; Benzimidazoles; Enterobacteriaceae; Nematode