title: Parallel Spectral Acquisition with Orthogonal ICR Cells.
abstract: FT-based high performance mass analyzers yield increased resolving power and mass measurement accuracy, yet require increased duration of signal acquisition that can limit many applications. The implementation of stronger magnetic fields, multiple detection electrodes for harmonic signal detection, and an array of multiple mass analyzers arranged along the magnetic field axis have been used to decrease required acquisition time. The results presented here show that multiple ion cyclotron resonance (ICR) mass analyzers can also be implemented orthogonal to the central magnetic field axis. The orthogonal ICR cell system presented here consisting of two cells (master and slave cells) was constructed with printed circuit boards and installed within a single superconducting magnet and vacuum system. A master cell was positioned, as is normally done with ICR cells, on the central magnetic field axis and a slave cell was located off this central axis, but directly adjacent and alongside the master cell. To achieve ion transfer between cells, ions that were initially trapped in the master cell were drifted across the magnetic field into the slave cell with application of a small DC field applied perpendicularly to the magnetic field axis. A subsequent population of ions was injected and accumulated in the master cell. Simultaneous excitation of cyclotron motion of ions in both cells was carried out; ICR signals from each cell were independently amplified and recorded in parallel. Presented here are the initial results of successful parallel spectral acquisition with this orthogonal dual ICR cell array. Graphical Abstract ᅟ.
authors.affiliation: Department of Genome Sciences, University of Washington, Seattle, WA, 98109, USA.
authors.forename: Sung-Gun
authors.initials: SG
authors.lastname: Park
authors.affiliation: GAA Custom Engineering, LLC, Benton City, WA, 99320, USA.
authors.forename: Gordon A
authors.initials: GA
authors.lastname: Anderson
authors.affiliation: Department of Genome Sciences, University of Washington, Seattle, WA, 98109, USA. jimbruce@uw.edu.
authors.forename: James E
authors.initials: JE
authors.lastname: Bruce
keywords: Array; FT-ICR; FTMS