title: Soluble ST2 is associated with disease severity in arrhythmogenic right ventricular cardiomyopathy.
abstract: OBJECTIVE
  Diagnostic and prognostic evaluation remains challenging in arrhythmogenic right ventricular cardiomyopathy (ARVC). We measured plasma concentration of soluble ST2 (sST2) and assessed its association with right ventricular (RV) function and ventricular arrhythmias in patients with ARVC.
  
  
  METHODS
  We included patients with ARVC and genotype positive relatives. Soluble ST2 was determined by ELISA. We assessed myocardial function by echocardiography including strain by speckle tracking technique.
  
  
  RESULTS
  We included 44 subjects (age 41 ± 15 years, 21 (48%) female). Soluble ST2 was associated with RV global strain (r = 0.44; p = 0.008), as well as with left ventricular (LV) function. Plasma levels of sST2 were higher in patients with ventricular arrhythmias than in patients without ventricular arrhythmias (35 ± 13 ng/mL vs. 26 ± 7 ng/mL, p = 0.009). The association between sST2 and ventricular arrhythmias remained significant even after adjusting for RV function (Wald = 5.2; p = 0.02).
  
  
  CONCLUSIONS
  Soluble ST2 is associated with RV and LV function in patients with ARVC. Soluble ST2 may aid in the determination of disease severity in ARVC.
authors.affiliation: a Department of Cardiology , Oslo University Hospital , Rikshospitalet , Oslo , Norway.|b Center for Heart Failure Research, Faculty of Medicine , University of Oslo , Oslo , Norway.
authors.forename: Kaspar
authors.initials: K
authors.lastname: Broch
authors.affiliation: a Department of Cardiology , Oslo University Hospital , Rikshospitalet , Oslo , Norway.|c Center for Cardiological Innovation, Oslo University Hospital , Rikshospitalet , Oslo , Norway.
authors.forename: Ida S
authors.initials: IS
authors.lastname: Leren
authors.affiliation: a Department of Cardiology , Oslo University Hospital , Rikshospitalet , Oslo , Norway.|c Center for Cardiological Innovation, Oslo University Hospital , Rikshospitalet , Oslo , Norway.
authors.forename: Jørg
authors.initials: J
authors.lastname: Saberniak
authors.affiliation: d Research Institute for Internal Medicine, Oslo University Hospital , Rikshospitalet , Oslo , Norway.|e Faculty of Medicine , University of Oslo , Oslo , Norway.
authors.forename: Thor
authors.initials: T
authors.lastname: Ueland
authors.affiliation: a Department of Cardiology , Oslo University Hospital , Rikshospitalet , Oslo , Norway.|c Center for Cardiological Innovation, Oslo University Hospital , Rikshospitalet , Oslo , Norway.|e Faculty of Medicine , University of Oslo , Oslo , Norway.
authors.forename: Thor
authors.initials: T
authors.lastname: Edvardsen
authors.affiliation: a Department of Cardiology , Oslo University Hospital , Rikshospitalet , Oslo , Norway.|b Center for Heart Failure Research, Faculty of Medicine , University of Oslo , Oslo , Norway.|e Faculty of Medicine , University of Oslo , Oslo , Norway.
authors.forename: Lars
authors.initials: L
authors.lastname: Gullestad
authors.affiliation: a Department of Cardiology , Oslo University Hospital , Rikshospitalet , Oslo , Norway.|c Center for Cardiological Innovation, Oslo University Hospital , Rikshospitalet , Oslo , Norway.|e Faculty of Medicine , University of Oslo , Oslo , Norway.
authors.forename: Kristina H
authors.initials: KH
authors.lastname: Haugaa
mesh_terms: D000328:Adult; D001145:Arrhythmias, Cardiac; D019571:Arrhythmogenic Right Ventricular Dysplasia / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology; D016022:Case-Control Studies; D004452:Echocardiography; D005260:Female; D006801:Humans; D000072179:Interleukin-1 Receptor-Like 1 Protein / Q000097:blood*; D008297:Male; D012720:Severity of Illness Index; D016277:Ventricular Function, Left; D016278:Ventricular Function, Right
chemical_list: C079241:IL1RL1 protein, human; D000072179:Interleukin-1 Receptor-Like 1 Protein
keywords: Arrhythmogenic right ventricular cardiomyopathy; ST2; biomarker; right ventricular function; ventricular arrhythmia