title: Towards a personalized surgical margin for breast conserving surgery-Implications of field cancerization in local recurrence.
abstract: The amount of normal tissue that should be excised during breast conserving surgery is widely debated. Tissue adjacent to breast tumors, although histologically normal, possesses many of the molecular abnormalities found in tumor tissues. Here, we propose that the ideal physical distance for a surgical margin may not be universal. Rather, an adequate surgical margin likely varies from patient to patient, depending on the biology of the tissue that remains after surgery. J. Surg. Oncol. 2017;115:109-115. © 2017 Wiley Periodicals, Inc.
authors.affiliation: Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico.
authors.forename: Katarina
authors.initials: K
authors.lastname: Lebya
authors.affiliation: Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico.
authors.forename: Randi
authors.initials: R
authors.lastname: Garcia-Smith
authors.forename: Radha
authors.initials: R
authors.lastname: Swaminathan
authors.affiliation: Department of Internal Medicine, University of New Mexico Health Science Center, Albuquerque, New Mexico.
authors.forename: Anna
authors.initials: A
authors.lastname: Jones
authors.affiliation: Department of Surgery, University of New Mexico Health Science Center, Albuquerque, New Mexico.
authors.forename: John
authors.initials: J
authors.lastname: Russell
authors.affiliation: Department of Pathology, University of New Mexico Health Science Center, Albuquerque, New Mexico.
authors.forename: Nancy
authors.initials: N
authors.lastname: Joste
authors.affiliation: Biochemistry and Molecular Biology, Schmid College of Science and Technology, Chapman University, Orange, California.
authors.forename: Marco
authors.initials: M
authors.lastname: Bisoffi
authors.affiliation: Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico.
authors.forename: Kristina
authors.initials: K
authors.lastname: Trujillo
mesh_terms: D001943:Breast Neoplasms / Q000601:surgery*; D005260:Female; D006801:Humans; D000072662:Margins of Excision; D015412:Mastectomy, Segmental; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D016896:Treatment Outcome
keywords: breast cancer; field cancerization; lumpectomy surgery