title: Pasteurized autograft reconstruction after resection of periacetabular malignant bone tumours.
abstract: BACKGROUND
  The treatment of periacetabular malignant bone tumours is challenging. Many methods of reconstruction after internal hemipelvectomy have been reported and each method has its own limitations. The aim of this study was to evaluate the oncological and functional outcomes of pasteurized autograft reconstruction after resection of periacetabular malignant bone tumours.
  
  
  METHODS
  Ten patients (six male, four female) with periacetabular malignant tumours, who underwent resection and reconstruction with pasteurized autograft, were retrospectively reviewed. The patients' average age at diagnosis was 40 years (range 13-65 years). There were five patients with chondrosarcoma, three with osteosarcoma, one with Ewing's sarcoma, and one with solitary metastatic thyroid carcinoma.
  
  
  RESULTS
  At the last follow-up, seven patients were alive (six with no evidence of the primary disease and one with lung metastasis for 5 months). The three other patients died of metastasis of the primary disease with a mean survival time of 12 (range 8-17) months postoperatively. The mean follow-up time for all patients was 45 (range 8-87) months. Local recurrence rate was 10%. The mean time of bone union was 12 (range 6-21) months after the operation. The mean Musculoskeletal Tumor Society score for all living patients at the last follow-up was 70.5% (range 43.3-86.7%).
  
  
  CONCLUSIONS
  Reconstruction with pasteurized autograft is a feasible method for treating periacetabular malignant bone tumours, with satisfactory oncological and functional outcomes and a relatively low incidence of complications.
authors.affiliation: Department of Orthopaedics, the Second Xiangya hospital, Central South University, 139 Renmin road, Changsha, 410011, People's Republic of China.
authors.forename: Xiaoning
authors.initials: X
authors.lastname: Guo
authors.affiliation: Department of Orthopaedics, the Second Xiangya hospital, Central South University, 139 Renmin road, Changsha, 410011, People's Republic of China.
authors.forename: Xiaoyang
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Orthopaedics, the Second Xiangya hospital, Central South University, 139 Renmin road, Changsha, 410011, People's Republic of China.
authors.forename: Tang
authors.initials: T
authors.lastname: Liu
authors.affiliation: Orthopedic Biomedical Materials Institute, Central South University, Changsha, 410083, People's Republic of China.
authors.forename: Cijun
authors.initials: C
authors.lastname: Shuai
authors.affiliation: Department of Orthopaedics, the Second Xiangya hospital, Central South University, 139 Renmin road, Changsha, 410011, People's Republic of China. zhangqing65230@126.com.
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhang
mesh_terms: D000077:Acetabulum / Q000473:pathology / Q000601:surgery*; D000293:Adolescent; D000328:Adult; D000368:Aged; D064592:Autografts; D001859:Bone Neoplasms / Q000473:pathology / Q000601:surgery*; D016025:Bone Transplantation; D002813:Chondrosarcoma / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012516:Osteosarcoma / Q000473:pathology / Q000601:surgery*; D011379:Prognosis; D019651:Plastic Surgery Procedures / Q000379:methods*; D012189:Retrospective Studies; D012512:Sarcoma, Ewing / Q000473:pathology / Q000601:surgery*; D015996:Survival Rate; D014182:Transplantation, Autologous; D055815:Young Adult
keywords: Autograft; Pasteurization; Periacetabular malignant bone tumour; Reconstruction