title: Neural plasticity and network remodeling: From concepts to pathology.
abstract: Neuroplasticity has been subject to a great deal of research in the last century. Recently, significant emphasis has been placed on the global effect of localized plastic changes throughout the central nervous system, and on how these changes integrate in a pathological context. Specifically, alterations of network functionality have been described in various pathological contexts to which corresponding structural alterations have been proposed. However, considering the amount of literature and the different pathological contexts, an integration of this information is still lacking. In this paper we will review the concepts of neural plasticity as well as their repercussions on network remodeling and provide a possible explanation to how these two concepts relate to each other. We will further examine how alterations in different pathological contexts may relate to each other and will discuss the concept of plasticity diseases, its models and implications.
authors.affiliation: Department of Experimental and Clinical Medicine, Physiological Sciences Section, University of Florence, Florence, Italy.
authors.forename: Erez James
authors.initials: EJ
authors.lastname: Cohen
authors.affiliation: Department of Experimental and Clinical Medicine, Physiological Sciences Section, University of Florence, Florence, Italy.
authors.forename: Eros
authors.initials: E
authors.lastname: Quarta
authors.affiliation: Department of Experimental and Clinical Medicine, Physiological Sciences Section, University of Florence, Florence, Italy.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Bravi
authors.affiliation: Department of Psychology, Catholic University, 20123 Milan, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Granato
authors.affiliation: Department of Experimental and Clinical Medicine, Physiological Sciences Section, University of Florence, Florence, Italy. Electronic address: diego@unifi.it.
authors.forename: Diego
authors.initials: D
authors.lastname: Minciacchi
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology / Q000502:physiology* / Q000503:physiopathology*; D006801:Humans; D009434:Neural Pathways / Q000473:pathology / Q000502:physiology / Q000503:physiopathology; D009473:Neuronal Plasticity / Q000502:physiology*
keywords: functional plasticity; maladaptive plasticity; neural oscillations; plasticity disease; structural plasticity; synaptic plasticity