title: COLIN trial: Value of colchicine in the treatment of patients with acute myocardial infarction and inflammatory response.
abstract: BACKGROUND
  Inflammation is involved during acute myocardial infarction, and could be an interesting target to prevent ischaemia-reperfusion injuries. Colchicine, known for its pleiotropic anti-inflammatory effects, could decrease systemic inflammation in this context.
  
  
  OBJECTIVE
  To evaluate the impact of colchicine on inflammation in patients admitted for ST-segment elevation myocardial infarction (STEMI).
  
  
  METHODS
  All patients admitted for STEMI with one of the main coronary arteries occluded, and successfully treated with percutaneous coronary intervention, were included consecutively. Patients were randomized to receive either 1mg colchicine once daily for 1 month plus optimal medical treatment or optimal medical treatment only. C-reactive protein (CRP) was assessed at admission and daily until hospital discharge. The primary endpoint was CRP peak value during the index hospitalization.
  
  
  RESULTS
  Forty-four patients were included: 23 were treated with colchicine; 21 received conventional treatment only. At baseline, both groups were well balanced regarding age, sex, risk factors, thrombolysis in myocardial infarction flow and reperfusion delay. The culprit artery was more often the left anterior descending artery in the colchicine group (P=0.07), reflecting a more severe group. There was no significant difference in mean CRP peak value between the colchicine and control groups (29.03mg/L vs 21.86mg/L, respectively; P=0.36), even after adjustment for type of culprit artery (26.99 vs 24.99mg/L, respectively; P=0.79).
  
  
  CONCLUSIONS
  In our study, the effect of colchicine on inflammation in the context of STEMI could not be demonstrated. Further larger studies may clarify the impact of colchicine in acute myocardial infarction.
authors.affiliation: UFR de médecine, cardiology department, hôpital Arnaud-de-Villeneuve, université Montpellier 1, CHU de Montpellier, 371, avenue du Doyen-Gaston-Giraud, 34295 Montpellier cedex 05, France.
authors.forename: Mariama
authors.initials: M
authors.lastname: Akodad
authors.affiliation: UFR de médecine, cardiology department, hôpital Arnaud-de-Villeneuve, université Montpellier 1, CHU de Montpellier, 371, avenue du Doyen-Gaston-Giraud, 34295 Montpellier cedex 05, France.
authors.forename: Benoît
authors.initials: B
authors.lastname: Lattuca
authors.affiliation: UFR de médecine, medical information department, université Montpellier 1, CHU de Montpellier, 34295 Montpellier, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Nagot
authors.affiliation: UFR de médecine, medical information department, université Montpellier 1, CHU de Montpellier, 34295 Montpellier, France.
authors.forename: Vera
authors.initials: V
authors.lastname: Georgescu
authors.affiliation: UFR de médecine, medical information department, université Montpellier 1, CHU de Montpellier, 34295 Montpellier, France.
authors.forename: Mathilde
authors.initials: M
authors.lastname: Buisson
authors.affiliation: UFR de médecine, department of biochemistry, université Montpellier 1, CHU de Montpellier, 34295 Montpellier, France; PhyMedExp, Inserm U1046, CNRS UMR 9214, university of Montpellier, 34295 Montpellier, France.
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Cristol
authors.affiliation: UFR de médecine, cardiology department, hôpital Arnaud-de-Villeneuve, université Montpellier 1, CHU de Montpellier, 371, avenue du Doyen-Gaston-Giraud, 34295 Montpellier cedex 05, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Leclercq
authors.affiliation: UFR de médecine, cardiology department, hôpital Arnaud-de-Villeneuve, université Montpellier 1, CHU de Montpellier, 371, avenue du Doyen-Gaston-Giraud, 34295 Montpellier cedex 05, France.
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Macia
authors.affiliation: UFR de médecine, cardiology department, hôpital Arnaud-de-Villeneuve, université Montpellier 1, CHU de Montpellier, 371, avenue du Doyen-Gaston-Giraud, 34295 Montpellier cedex 05, France.
authors.forename: Richard
authors.initials: R
authors.lastname: Gervasoni
authors.affiliation: UFR de médecine, cardiology department, hôpital Arnaud-de-Villeneuve, université Montpellier 1, CHU de Montpellier, 371, avenue du Doyen-Gaston-Giraud, 34295 Montpellier cedex 05, France.
authors.forename: Thien-Tri
authors.initials: TT
authors.lastname: Cung
authors.affiliation: UFR de médecine, cardiology department, hôpital Arnaud-de-Villeneuve, université Montpellier 1, CHU de Montpellier, 371, avenue du Doyen-Gaston-Giraud, 34295 Montpellier cedex 05, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Cade
authors.affiliation: UFR de médecine, cardiology department, hôpital Arnaud-de-Villeneuve, université Montpellier 1, CHU de Montpellier, 371, avenue du Doyen-Gaston-Giraud, 34295 Montpellier cedex 05, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Cransac
authors.affiliation: UFR de médecine, cardiology department, hôpital Arnaud-de-Villeneuve, université Montpellier 1, CHU de Montpellier, 371, avenue du Doyen-Gaston-Giraud, 34295 Montpellier cedex 05, France.
authors.forename: Jessica
authors.initials: J
authors.lastname: Labour
authors.affiliation: UFR de médecine, department of biochemistry, université Montpellier 1, CHU de Montpellier, 34295 Montpellier, France.
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Dupuy
authors.affiliation: UFR de médecine, cardiology department, hôpital Arnaud-de-Villeneuve, université Montpellier 1, CHU de Montpellier, 371, avenue du Doyen-Gaston-Giraud, 34295 Montpellier cedex 05, France; PhyMedExp, Inserm U1046, CNRS UMR 9214, university of Montpellier, 34295 Montpellier, France. Electronic address: francois.roubille@gmail.com.
authors.forename: François
authors.initials: F
authors.lastname: Roubille
mesh_terms: D000368:Aged; D000893:Anti-Inflammatory Agents / Q000009:adverse effects / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D003078:Colchicine / Q000009:adverse effects / Q000627:therapeutic use*; D054059:Coronary Occlusion / Q000097:blood / Q000000981:diagnostic imaging / Q000628:therapy*; D004452:Echocardiography; D005260:Female; D005602:France; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D018836:Inflammation Mediators / Q000097:blood*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention; D011446:Prospective Studies; D000072657:ST Elevation Myocardial Infarction / Q000097:blood / Q000000981:diagnostic imaging / Q000628:therapy*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D015415:Biomarkers; D018836:Inflammation Mediators; D002097:C-Reactive Protein; D003078:Colchicine
keywords: Acute coronary syndrome; Cardiovascular disease; Colchicine; Heart failure; Infarctus du myocarde; Insuffisance cardiaque; Myocardial infarction; Pathologies cardiovasculaires; Syndrome coronarien aigu