title: [(CAG)n polymorphism of the ATXN2 gene, a new marker of susceptibility for type 2 diabetes mellitus].
abstract: OBJECTIVE
  Estimate whether there is an association between the (CAG)n repeat in the ATXN2 gene in the Mexican population and type 2 diabetes mellitus (DM).
  
  
  METHODS
  Epidemiological case-control study, including healthy people and diabetics. (CAG)n expansion was detected by end-point polymerase chain reaction (PCR). PCR outputs were analyzed by electrophoresis (PAGE 8%) and silver nitrate staining.
  
  
  RESULTS
  (CAG)n nucleotide allele distribution in the study population was similar to that reported in central Mexico. The 22-repeat allele is the most frequent; however, there is an association with carriers of long repeats in the normal range with diabetes.
  
  
  CONCLUSIONS
  The results suggest that the (CAG)n repeat of the ATXN2 gene could be a causal factor for type 2 DM.
authors.affiliation: Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud (CUCS), Benemérita Universidad de Guadalajara, Jalisco, México.
authors.forename: Luis J
authors.initials: LJ
authors.lastname: Flores-Alvarado
authors.affiliation: Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud (CUCS), Benemérita Universidad de Guadalajara, Jalisco, México.
authors.forename: Nory O
authors.initials: NO
authors.lastname: Dávalos-Rodríguez
authors.affiliation: Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud (CUCS), Benemérita Universidad de Guadalajara, Jalisco, México.
authors.forename: Diana
authors.initials: D
authors.lastname: García-Cruz
authors.affiliation: Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud (CUCS), Benemérita Universidad de Guadalajara, Jalisco, México.
authors.forename: Perla M
authors.initials: PM
authors.lastname: Madrigal-Ruiz
authors.affiliation: Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud (CUCS), Benemérita Universidad de Guadalajara, Jalisco, México.
authors.forename: Rosalba
authors.initials: R
authors.lastname: Ruiz-Mejía
authors.affiliation: Departamento de Salud Pública, Centro Universitario de Ciencias de la Salud (CUCS), Benemérita Universidad de Guadalajara, Jalisco, México.
authors.forename: María E
authors.initials: ME
authors.lastname: Aguilar-Aldrete
authors.affiliation: Instituto de Investigaciones sobre la Salud Pública, Universidad de la Sierra Sur, Miahuatlán de Porfirio Díaz, Oaxaca, México.
authors.forename: Nemesio
authors.initials: N
authors.lastname: Villa-Ruano
authors.affiliation: Instituto de Investigaciones sobre la Salud Pública, Universidad de la Sierra Sur, Miahuatlán de Porfirio Díaz, Oaxaca, México.
authors.forename: Sergio Alberto
authors.initials: SA
authors.lastname: Ramirez-Garcia
mesh_terms: D000328:Adult; D000483:Alleles; D000067698:Ataxin-2 / Q000235:genetics*; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: C000593752:ATXN2 protein, human; D000067698:Ataxin-2; D005819:Genetic Markers