title: Prediction of Fibrosis Progression Rate in Patients with Chronic Hepatitis C Genotype 4: Role of Cirrhosis Risk Score and Host Factors.
abstract: The rate of liver fibrosis progression in chronic hepatitis C (CHC) patients is highly variable and affected by different factors. This study aimed to assess the role of cirrhosis risk score (CRS) based on 7 genetic variants (7 single-nucleotide polymorphisms [SNPs]) and host factors (age and sex) in the prediction of the rate of fibrosis progression in CHC. Duration of infection was determined in 115 patients. The fibrosis progression rate (FPR) per year was calculated as the ratio between fibrosis stage and the duration of infection. SNP genotyping were performed and CRS was determined based on it. FPR was significantly elevated in patients who acquired infection at age >40 years versus those who acquired infection at 30-40 years and those who acquired infection at <30 years. Median FPR was significantly higher in males than females (0.17 vs. 0.15) with P = 0.001. CRS value ≥0.8 is predictive of patients with high risk for cirrhosis, and CRS value <0.5 is predictive of patients with low risk for cirrhosis. There was significant positive correlation between CRS and FPR (P ≤ 0.001). CRS based on 7 SNPs at cutoff value ≥0.8, age at infection >40 years, and male sex are predictors of higher FPR.
authors.affiliation: 1 Department of Tropical Medicine, Mansoura University , Mansoura, Egypt .
authors.forename: Tarek
authors.initials: T
authors.lastname: Besheer
authors.affiliation: 1 Department of Tropical Medicine, Mansoura University , Mansoura, Egypt .
authors.forename: Mahmoud
authors.initials: M
authors.lastname: El-Bendary
authors.affiliation: 1 Department of Tropical Medicine, Mansoura University , Mansoura, Egypt .
authors.forename: Hatem
authors.initials: H
authors.lastname: Elalfy
authors.affiliation: 1 Department of Tropical Medicine, Mansoura University , Mansoura, Egypt .
authors.forename: Mohamed
authors.initials: M
authors.lastname: Abd El-Maksoud
authors.affiliation: 1 Department of Tropical Medicine, Mansoura University , Mansoura, Egypt .
authors.forename: Mohamed
authors.initials: M
authors.lastname: Salah
authors.affiliation: 2 Department of Pathlogy, Mansoura University , Mansoura, Egypt .
authors.forename: Khaled
authors.initials: K
authors.lastname: Zalata
authors.affiliation: 2 Department of Pathlogy, Mansoura University , Mansoura, Egypt .
authors.forename: Wagdi
authors.initials: W
authors.lastname: Elkashef
authors.affiliation: 3 Department of Clinical Pathology, Mansoura University , Mansoura, Egypt .
authors.forename: Heba
authors.initials: H
authors.lastname: Elshahawy
authors.affiliation: 3 Department of Clinical Pathology, Mansoura University , Mansoura, Egypt .
authors.forename: Doaa
authors.initials: D
authors.lastname: Raafat
authors.affiliation: 3 Department of Clinical Pathology, Mansoura University , Mansoura, Egypt .
authors.forename: Wafaa
authors.initials: W
authors.lastname: Elemshaty
authors.affiliation: 3 Department of Clinical Pathology, Mansoura University , Mansoura, Egypt .
authors.forename: Noha
authors.initials: N
authors.lastname: Almashad
authors.affiliation: 3 Department of Clinical Pathology, Mansoura University , Mansoura, Egypt .
authors.forename: Hosam
authors.initials: H
authors.lastname: Zaghloul
authors.affiliation: 4 Department of Public Health and Preventive Medicine, Mansoura University , Mansoura, Egypt .
authors.forename: Abdel-Hady
authors.initials: AH
authors.lastname: El-Gilany
authors.affiliation: 5 Department of Diagnostic Radiology, Mansoura University , Mansoura, Egypt .
authors.forename: Ahmed Abdel Khalek
authors.initials: AA
authors.lastname: Abdel Razek
authors.affiliation: 6 Gastroenterology Surgical Center, Mansoura Faculty of Medicine, Mansoura University , Mansoura, Egypt .
authors.forename: Mohamed
authors.initials: M
authors.lastname: Abd Elwahab
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers; D001706:Biopsy; D018450:Disease Progression; D005260:Female; D005838:Genotype; D016174:Hepacivirus / Q000235:genetics*; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000821:virology*; D054884:Host-Pathogen Interactions; D006801:Humans; D008103:Liver Cirrhosis / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D018570:Risk Assessment; D013997:Time Factors; D055815:Young Adult
chemical_list: D015415:Biomarkers
keywords: CHC; cirrhosis risk score; fibrosis progression; host factors