title: Clinical characteristics with patterns of relapse and survival analysis of ovarian clear cell carcinoma.
abstract: OBJECTIVE
  To analyze clinical characteristics, patterns of relapse, and treatment outcomes of clearcell carcinoma of the ovary (CCO).
  
  
  METHODS
  Case files of 51 patients diagnosed with CCO between 2003 and 2010 were reviewed.
  
  
  RESULTS
  The median age at diagnosis was 48 years (27-64 years). Fifty percent presented with nonspecific gastrointestinal symptoms. The median serum Ca125 was 74 IU/ml (6-1567 U/ml). Optimal cytoreduction was achieved in 32 (62.7%) patients. Of the 51 patients in this series, 34 (66.6%) had Stage I disease; Stage Ia in 12 (23.6%), Stage Ib in 1(1.9%), and Stage Ic in 21 (41.1%). Thirteen (25.6%) presented with Stage III and 4 (7.8%) with Stage IV. No patient had Stage II disease. All patients received 4-6 cycles of platinum-based combination chemotherapy. There were 18 relapses (35.2%), with disease-free intervals <6 months in 9, 6-12 months in 4, and >12 months in 5, respectively. Of them 33.3% had a recurrent pelvic mass. The median survival after relapse was 14 months. There were 13 deaths, 11 due to disease progression, 1 due to chemo toxicity, and 1 unrelated to disease. At a median follow up of 28 months, disease-free survival (DFS) and overall survival (OS) of patients with Stage I-Stage II (early) disease was 64% and 80%, respectively. In patients with advanced disease, that is, Stages III and IV, DFS and OS were 35% and 38%, respectively.
  
  
  CONCLUSIONS
  CCO generally presents at an early stage but has a high propensity for relapse. Patients with early-stage disease have a relatively good prognosis as compared with those with advanced-stage disease.
authors.affiliation: Depatment of Gynecological Oncology, Tata Memorial Hospital, Mumbai, India.
authors.forename: S
authors.initials: S
authors.lastname: Kaur
authors.affiliation: Depatment of Gynecological Oncology, Tata Memorial Hospital, Mumbai, India.
authors.forename: R A
authors.initials: RA
authors.lastname: Kerkar
authors.affiliation: Depatment of Gynecological Oncology, Tata Memorial Hospital, Mumbai, India.
authors.forename: A
authors.initials: A
authors.lastname: Maheshwari
authors.affiliation: Depatment of Gynecological Oncology, Tata Memorial Hospital, Mumbai, India.
authors.forename: T S
authors.initials: TS
authors.lastname: Shylasree
authors.affiliation: Depatment of Medical Oncology, Tata Memorial Hospital, Mumbai, India.
authors.forename: S
authors.initials: S
authors.lastname: Gupta
authors.affiliation: Depatment of Pathology, Tata Memorial Hospital, Mumbai, India.
authors.forename: K
authors.initials: K
authors.lastname: Deodhar
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000401:mortality / Q000473:pathology*; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000401:mortality / Q000473:pathology*; D012008:Recurrence; D016019:Survival Analysis