title: Lung Gene Expression Analysis (LGEA): an integrative web portal for comprehensive gene expression data analysis in lung development.
abstract: 'LungGENS', our previously developed web tool for mapping single-cell gene expression in the developing lung, has been well received by the pulmonary research community. With continued support from the 'LungMAP' consortium, we extended the scope of the LungGENS database to accommodate transcriptomics data from pulmonary tissues and cells from human and mouse at different stages of lung development. Lung Gene Expression Analysis (LGEA) web portal is an extended version of LungGENS useful for the analysis, display and interpretation of gene expression patterns obtained from single cells, sorted cell populations and whole lung tissues. The LGEA web portal is freely available at http://research.cchmc.org/pbge/lunggens/mainportal.html.
authors.affiliation: The Perinatal Institute and Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
authors.forename: Yina
authors.initials: Y
authors.lastname: Du
authors.affiliation: The Perinatal Institute and Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Kitzmiller
authors.affiliation: The Perinatal Institute and Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
authors.forename: Anusha
authors.initials: A
authors.lastname: Sridharan
authors.affiliation: The Perinatal Institute and Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
authors.forename: Anne K
authors.initials: AK
authors.lastname: Perl
authors.affiliation: The Perinatal Institute and Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
authors.forename: James P
authors.initials: JP
authors.lastname: Bridges
authors.affiliation: Department of Pediatrics, University of Rochester, Rochester, New York, USA.
authors.forename: Ravi S
authors.initials: RS
authors.lastname: Misra
authors.affiliation: Department of Pediatrics, University of Rochester, Rochester, New York, USA.
authors.forename: Gloria S
authors.initials: GS
authors.lastname: Pryhuber
authors.affiliation: Department of Pediatrics, University of Rochester, Rochester, New York, USA.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Mariani
authors.affiliation: Department of Pediatrics, University of Rochester, Rochester, New York, USA.
authors.forename: Soumyaroop
authors.initials: S
authors.lastname: Bhattacharya
authors.affiliation: The Perinatal Institute and Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
authors.forename: Minzhe
authors.initials: M
authors.lastname: Guo
authors.affiliation: Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
authors.forename: S Steven
authors.initials: SS
authors.lastname: Potter
authors.affiliation: Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
authors.forename: Phillip
authors.initials: P
authors.lastname: Dexheimer
authors.affiliation: Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
authors.forename: Bruce
authors.initials: B
authors.lastname: Aronow
authors.affiliation: The Perinatal Institute and Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
authors.forename: Alan H
authors.initials: AH
authors.lastname: Jobe
authors.affiliation: The Perinatal Institute and Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Whitsett
authors.affiliation: The Perinatal Institute and Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.|Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
authors.forename: Yan
authors.initials: Y
authors.lastname: Xu
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D019295:Computational Biology / Q000379:methods*; D015870:Gene Expression; D020869:Gene Expression Profiling / Q000379:methods*; D006801:Humans; D020407:Internet; D008168:Lung / Q000254:growth & development*; D051379:Mice; D012984:Software; D014157:Transcription Factors
chemical_list: D014157:Transcription Factors
keywords: Airway Epithelium; Surfactant protein; Systemic disease and lungs; TTF-1