title: Anastomosing Hemangioma of the Ovary: A Clinicopathological Study of Six Cases with Stromal Luteinization.
abstract: We report six cases of anastomosing hemangioma of the ovary. All lesions were unilateral and arose in 43 to 81 year old females. In all but one patient, the tumor was asymptomatic and represented incidental finding. The exception was a tumor associated with massive ascites and elevated CA 125. The tumors were, on cut section, spongy and dark violet in color. The size of tumors ranged from 0.5 to 3.5 cm. All lesions showed the same histological features and consisted of capillary sized anastomosing vessels with sinusoid-like pattern intermingled with sporadic medium sized vessels. Interestingly, in all cases there were areas of luteinized cells at the tumor periphery, which ranged from rare small nests to multiple and commonly confluent areas. In one tumor, components of mature adipose tissue were present. Immunohistochemically, all tumors were CD31 and CD34 positive. Other markers examined were negative, including; estrogen receptor, progesterone receptor, androgen receptor, and D2-40. Proliferative activity (Ki-67 index) was very low in all cases. Anastomosing hemangioma is a rare entity, only 8 lesions occurring in ovary has been described from its initial description in 2009. We report six additional cases with their clinicopathological correlation.
authors.affiliation: Department of Pathology, First Faculty of Medicine Charles University and General University Hospital in Prague, Studnickova 2, 12800, Prague 2, Czech Republic. pdundr@seznam.cz.
authors.forename: Pavel
authors.identifier: http://orcid.org/0000-0002-8940-6124
authors.initials: P
authors.lastname: Dundr
authors.affiliation: Department of Pathology, First Faculty of Medicine Charles University and General University Hospital in Prague, Studnickova 2, 12800, Prague 2, Czech Republic.
authors.forename: Kristýna
authors.initials: K
authors.lastname: Němejcová
authors.affiliation: The Fingerland Department of Pathology, Charles University, Faculty of Medicine and University Hospital Hradec Kralove, Hradec Kralove, Czech Republic.
authors.forename: Jan
authors.initials: J
authors.lastname: Laco
authors.affiliation: Department of Pathology, First Faculty of Medicine Charles University and General University Hospital in Prague, Studnickova 2, 12800, Prague 2, Czech Republic.
authors.forename: Helena
authors.initials: H
authors.lastname: Skálová
authors.affiliation: Department of Pathology, First Faculty of Medicine Charles University and General University Hospital in Prague, Studnickova 2, 12800, Prague 2, Czech Republic.
authors.forename: Lenka
authors.initials: L
authors.lastname: Bauerová
authors.affiliation: Department of Pathology, First Faculty of Medicine Charles University and General University Hospital in Prague, Studnickova 2, 12800, Prague 2, Czech Republic.|Department of Pathology and Molecular Medicine, Thomayer Hospital, Prague, Czech Republic.
authors.forename: Radoslav
authors.initials: R
authors.lastname: Matěj
authors.affiliation: Gynecologic Oncology Center, Department of Obstetrics and Gynecology, First Faculty of Medicine Charles University and General University Hospital in Prague, Prague, Czech Republic.
authors.forename: Daniela
authors.initials: D
authors.lastname: Fischerová
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D006391:Hemangioma / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor
keywords: Anastomosing hemagioma; Capillary hemangioma; Ovary; Stromal luteinization; Urogenital tract