title: Antitumor Activity of Isosteroidal Alkaloids from the Plants in the Genus Veratrum and Fritillaria.
abstract: Isosteroidal alkaloids are a category of promising bioactive compounds which mostly exist in plants of genus Veratrum and Fritillaria. The pharmacological activities of isosteroidal alkaloids include antihypertensive, antitussive, anti-inflammatory, antithrombosis, among others. Recently, some studies show that this kind of alkaloids exhibited significant antitumor activity. To the best of our knowledge, there is no review focusing on their antitumor activity and mechanism of their antitumor activity. To fill the gap, in this review, we summarized antitumor effects of the isosteroidal alkaloids from genus Veratrum and Fritillaria on different tumors and the mechanisms of their antitumor activity. In conclusion, this kind of alkaloids has extensive antitumor activity, and there are several main mechanisms of their antitumor activity, including the Hedgehog signaling pathway, caspase-3 dependent apoptosis, cell cycle, and autophagy.
authors.affiliation: Department of Pharmacognosy, West China College of Pharmacy, Sichuan University, No. 17, Duan 3, Renmin Nan Road, Chengdu 610041. China.
authors.forename: Yuanhong
authors.initials: Y
authors.lastname: Shang
authors.affiliation: Department of Pharmacognosy, West China College of Pharmacy, Sichuan University, No. 17, Duan 3, Renmin Nan Road, Chengdu 610041. China.
authors.forename: Qingdan
authors.initials: Q
authors.lastname: Du
authors.affiliation: Department of Pharmacognosy, West China College of Pharmacy, Sichuan University, No. 17, Duan 3, Renmin Nan Road, Chengdu 610041. China.
authors.forename: Simei
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of Pharmacognosy, Faculty of Life Sciences, University of Vienna, Vienna A1090. Austria.
authors.forename: Maksorvor
authors.initials: M
authors.lastname: Staadler
authors.affiliation: Department of Pharmacognosy, West China College of Pharmacy, Sichuan University, No. 17, Duan 3, Renmin Nan Road, Chengdu 610041. China.
authors.forename: Shu
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Pharmacognosy, West China College of Pharmacy, Sichuan University, No. 17, Duan 3, Renmin Nan Road, Chengdu 610041. China.
authors.forename: Dongdong
authors.initials: D
authors.lastname: Wang
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects; D001343:Autophagy / Q000187:drug effects; D002453:Cell Cycle / Q000187:drug effects; D031410:Fritillaria / Q000737:chemistry*; D053823:Hedgehog Proteins / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction / Q000187:drug effects; D014703:Veratrum / Q000737:chemistry*; D014704:Veratrum Alkaloids / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D053823:Hedgehog Proteins; D014704:Veratrum Alkaloids
keywords: Fritillaria; Isosteroidal alkaloids; Veratrum; antitumor activity; mechanism; traditional chinese medicine