title: GLUT-1 overexpression as an unfavorable prognostic biomarker in patients with colorectal cancer.
abstract: BACKGROUND
  Glucose transporter-1 (GLUT-1) exhibits altered expression in colorectal cancer (CRC). The aim of this study was to explore the association between GLUT-1 and survival conditions, as well as clinical features in CRC by meta-analysis.
  
  
  METHODS
  Relevant studies were searched through predefined strategies, hazard ratios (HRs), odds ratios (ORs), and their 95% confidence intervals (CIs) were used as effective measures.
  
  
  RESULTS
  A total of 14 studies with 2,077 patients were included in this meta-analysis. The results showed that GLUT-1 was not significantly associated with overall survival (OS) (HR=1.28, 95% CI=0.86-1.91, p=0.22) or disease-free survival (DFS) (HR=1.71, 95% CI=0.78-3.72, p=0.179). However, subgroup analysis indicated that GLUT-1 was a significant biomarker for poor DFS in rectal cancer (HR=2.47, 95% CI=1.21-5.05, p=0.013). GLUT-1 expression was also found to be significantly correlated with the presence of lymph node metastasis (n=8, OR=2.14, 95% CI=1.66-2.75, p<0.001), T stage (n=6, OR=1.73, 95% CI=1.17-2.58, p=0.007), higher Dukes stage (n=5, OR=2.92, 95% CI=2.16-3.95, p<0.001), female sex (n=4, OR=2.92, 95% CI=2.16-3.95, p<0.001), and presence of liver metastasis (n=3, OR=1.82, 95% CI=1.06-3.12, p=0.03).
  
  
  CONCLUSIONS
  In conclusion, this meta-analysis showed that GLUT-1 was associated with poor DFS in rectal cancer (RC). Furthermore, GLUT-1 was also an indicator of aggressive clinical features in CRC.
authors.affiliation: Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Gastroenterology and Hepatology, Chinese PLA 261 Hospital, Beijing, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wen
authors.affiliation: Nanlou Department of Respiratory Disease, Chinese PLA General Hospital, Beijing, China.
authors.forename: Tian
authors.initials: T
authors.lastname: Tian
authors.affiliation: Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing, China.
authors.forename: Zhongsheng
authors.initials: Z
authors.lastname: Lu
authors.affiliation: Department of Immunology/Bio-therapeutic, Institute of Basic Medicine, Chinese PLA General Hospital, Beijing, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing, China.
authors.forename: Zikai
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing, China.
authors.forename: Xiangdong
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing, China.
authors.forename: Yunsheng
authors.initials: Y
authors.lastname: Yang
mesh_terms: D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D051272:Glucose Transporter Type 1 / Q000096:biosynthesis*; D006801:Humans; D011379:Prognosis; D016019:Survival Analysis
chemical_list: D051272:Glucose Transporter Type 1; C495677:SLC2A1 protein, human
keywords: GLUT-1; biomarker; colorectal cancer; meta-analysis; survival