title: Does an Integrated Care Intervention for COPD Patients Have Long-Term Effects on Quality of Life and Patient Activation? A Prospective, Open, Controlled Single-Center Intervention Study.
abstract: Implementation of the COPD-Home integrated disease management (IDM) intervention at discharge after hospitalizations for acute exacerbations of COPD (AECOPD) led to reduced hospital utilization during the following 24 months compared to the year prior to study start.
  
  
  
  To analyze the impact of the COPD-Home IDM intervention on health related quality of life, symptoms of anxiety and depression, and the degree of patient activation during 24 months of follow-up and to assess the association between these outcomes.
  
  
  
  A single center, prospective, open, controlled clinical study. Changes in The St. George Respiratory Questionnaire (SGRQ), the Hospital anxiety (HADS-A) and depression (HADS-D) and the patient activation measure (PAM) scores were compared between the patients in the integrated care group (ICG) and the usual care group (UCG) 6, 12 and 24 months after enrolment.
  
  
  
  The questionnaire response rate was 80-96%. There were no statistically significant differences in the change of the SGRQ scores between the groups during follow up. After 12 months of follow-up there was a trend towards a reduction in the mean HADS-A score in the ICG compared to the UCG. The HADS-D scores remained stable in the ICG compared with an increasing trend in the UCG. Clinically significant difference in the PAM score was achieved only in the ICG, 6.7 (CI95% 0.7 to 7.5) compared to 3.6 (CI95% -1.4 to 8.6) in the UCG. In a logistic regression model a higher HADS-D score and current smoking significantly increased the odds for a low PAM score.
  
  
  
  The COPD-Home IDM intervention did not result in any statistically significant changes in mean SGRQ, HADS-A, HADS- D or PAM scores during the 24 months of follow-up.
  
  
  
  The ID number for the study in the Clinical.Trials.gov registration system is 17417. ClinicalTrials.gov Identifier: NCT 00702078.
authors.affiliation: Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway.|Department of Thoracic and Occupational Medicine, Trondheim University Hospital, Trondheim, Norway.
authors.forename: Elena
authors.identifier: 0000-0003-3776-7507
authors.initials: E
authors.lastname: Titova
authors.affiliation: The Faculty of medicine, Norwegian University of Science and Technology, Trondheim, Norway.
authors.forename: Øyvind
authors.initials: Ø
authors.lastname: Salvesen
authors.affiliation: Department of Health Education, University of Stavanger, Stavanger, Norway.
authors.forename: Signe Berit
authors.initials: SB
authors.lastname: Bentsen
authors.affiliation: Department of Thoracic and Occupational Medicine, Trondheim University Hospital, Trondheim, Norway.
authors.forename: Synnøve
authors.initials: S
authors.lastname: Sunde
authors.affiliation: Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway.|Department of Thoracic and Occupational Medicine, Trondheim University Hospital, Trondheim, Norway.
authors.forename: Sigurd
authors.initials: S
authors.lastname: Steinshamn
authors.affiliation: Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway.|Department of Thoracic and Occupational Medicine, Trondheim University Hospital, Trondheim, Norway.
authors.forename: Anne Hildur
authors.initials: AH
authors.lastname: Henriksen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001007:Anxiety; D019033:Delivery of Health Care, Integrated; D003863:Depression; D061345:Early Medical Intervention; D005260:Female; D006699:Home Care Services; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control / Q000628:therapy; D011788:Quality of Life; D013997:Time Factors