title: A highly selective fluorescent probe for Fe3+in living cells: a stress induced cell based model study.
abstract: A rhodamine-phenanthroline dyad based fluorescent probe 4 has been designed and synthesized which selectively monitors Fe3+ions among the various metal ions tested. Furthermore, probe 4 has been explored for monitoring of dynamic changes in the Fe3+ion level under aggressive Fenton reaction conditions using a cell based model study. More significantly, probe 4 has also been utilized for real time imaging of endogenous Fe3+ions in living C6 cell lines, the results of which demonstrated that probe 4 acts as an efficient fluorescent tool for Fe3+ion detection in biological systems.
authors.affiliation: Department of Chemistry, UGC Sponsored Centre for Advanced Studies-II, Guru Nanak Dev University, Amritsar, Punjab, India. mksharmaa@yahoo.co.in.
authors.forename: Neetu
authors.initials: N
authors.lastname: Sharma
authors.affiliation: Department of Chemistry, UGC Sponsored Centre for Advanced Studies-II, Guru Nanak Dev University, Amritsar, Punjab, India. mksharmaa@yahoo.co.in.
authors.forename: Shahi Imam
authors.initials: SI
authors.lastname: Reja
authors.affiliation: Department of Chemistry, UGC Sponsored Centre for Advanced Studies-II, Guru Nanak Dev University, Amritsar, Punjab, India. mksharmaa@yahoo.co.in.
authors.forename: Neha
authors.initials: N
authors.lastname: Gupta
authors.affiliation: Department of Chemistry, UGC Sponsored Centre for Advanced Studies-II, Guru Nanak Dev University, Amritsar, Punjab, India. mksharmaa@yahoo.co.in.
authors.forename: Vandana
authors.identifier: http://orcid.org/0000-0002-8740-1928
authors.initials: V
authors.lastname: Bhalla
authors.affiliation: Department of Botanical and Environmental Sciences, Guru Nanak Dev University, Amritsar, Punjab, India.
authors.forename: Davinder
authors.initials: D
authors.lastname: Kaur
authors.affiliation: Department of Botanical and Environmental Sciences, Guru Nanak Dev University, Amritsar, Punjab, India.
authors.forename: Saroj
authors.initials: S
authors.lastname: Arora
authors.affiliation: Department of Chemistry, UGC Sponsored Centre for Advanced Studies-II, Guru Nanak Dev University, Amritsar, Punjab, India. mksharmaa@yahoo.co.in.
authors.forename: Manoj
authors.initials: M
authors.lastname: Kumar
mesh_terms: D000818:Animals; D005290:Ferric Compounds / Q000032:analysis*; D005453:Fluorescence; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D008070:Lipopolysaccharides / Q000494:pharmacology; D018613:Microscopy, Confocal; D008954:Models, Biological; D061848:Optical Imaging; D018384:Oxidative Stress / Q000187:drug effects; D010618:Phenanthrolines / Q000737:chemistry*; D051381:Rats; D012235:Rhodamines / Q000737:chemistry*; D014407:Tumor Cells, Cultured
chemical_list: D005290:Ferric Compounds; D005456:Fluorescent Dyes; D008070:Lipopolysaccharides; D010618:Phenanthrolines; D012235:Rhodamines