title: Mapping complementary features of cross-species structural connectivity to construct realistic "Virtual Brains".
abstract: Modern systems neuroscience increasingly leans on large-scale multi-lab neuroinformatics initiatives to provide necessary capacity for biologically realistic modeling of primate whole-brain activity. Here, we present a framework to assemble primate brain's biologically plausible anatomical backbone for such modeling initiatives. In this framework, structural connectivity is determined by adding complementary information from invasive macaque axonal tract tracing and non-invasive human diffusion tensor imaging. Both modalities are combined by means of available interspecies registration tools and a newly developed Bayesian probabilistic modeling approach to extract common connectivity evidence. We demonstrate how this novel framework is embedded in the whole-brain simulation platform called The Virtual Brain (TVB). Hum Brain Mapp 38:2080-2093, 2017. © 2017 Wiley Periodicals, Inc.
authors.affiliation: Rotman Research Institute of Baycrest Centre, University of Toronto, Toronto, Ontario, Canada, M6A 2E1.|McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada, H3A 2B4.
authors.forename: Gleb
authors.initials: G
authors.lastname: Bezgin
authors.affiliation: Department of Neurology, University of California, Irvine, 200 Manchester Avenue, Suite 206, Orange, California.
authors.forename: Ana
authors.initials: A
authors.lastname: Solodkin
authors.affiliation: Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Radboud University Nijmegen, Nijmegen, AJ, 6525, the Netherlands.|Institute of Neuroscience and Medicine (INM-6) and Institute for Advanced Simulation (IAS-6), Jülich Research Centre and JARA, Jülich, 52425, Germany.
authors.forename: Rembrandt
authors.initials: R
authors.lastname: Bakker
authors.affiliation: Department of Neurology, Charite - University Medicine, Berlin, Germany.|Minerva Research Group Brain Modes, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.|Bernstein Focus State Dependencies of Learning & Bernstein Center for Computational Neuroscience, Berlin, Germany.|Berlin School of Mind and Brain & Mind & Brain Institute, Humboldt University, Berlin, Germany.
authors.forename: Petra
authors.initials: P
authors.lastname: Ritter
authors.affiliation: Rotman Research Institute of Baycrest Centre, University of Toronto, Toronto, Ontario, Canada, M6A 2E1.|Department of Psychology, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Anthony R
authors.initials: AR
authors.lastname: McIntosh
mesh_terms: D000293:Adolescent; D000328:Adult; D000465:Algorithms; D000818:Animals; D001921:Brain / Q000033:anatomy & histology* / Q000000981:diagnostic imaging; D001931:Brain Mapping; D063132:Connectome; D016208:Databases, Factual; D056324:Diffusion Tensor Imaging; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D046609:Libraries, Digital; D008251:Macaca; D008297:Male; D008959:Models, Neurological; D015233:Models, Statistical; D009434:Neural Pathways / Q000033:anatomy & histology* / Q000000981:diagnostic imaging / Q000502:physiology; D013045:Species Specificity; D055815:Young Adult
keywords: Bayesian modeling; The Virtual Brain; cerebral cortex; connectivity; diffusion tensor imaging; neuroanatomy; primate brain; subcortex; tract tracing