title: Transoral laser resection of glottic carcinoma: what is the significance of anterior commissure involvement?
abstract: BACKGROUND
  The optimal management of glottic carcinoma involving the anterior commissure is controversial.
  
  
  METHODS
  A retrospective analysis was conducted of 76 patients with glottic squamous cell carcinoma treated by transoral carbon dioxide laser resection by a single surgeon.
  
  
  RESULTS
  Sixty-three patients (with tumour stage Tis-T3) were eligible for inclusion. Thirty patients had involvement of the anterior commissure; these patients were significantly more likely to have either uncertain or positive margins (63.3 vs 30.3 per cent, p = 0.012), and were also more likely to receive adjuvant radiotherapy (40 vs 3.2 per cent, p = 0.0005). The overall laryngeal preservation rate was 96.8 per cent; there was no statistically significant difference between those with and without anterior commissure involvement (96.7 and 96.9 per cent respectively).
  
  
  CONCLUSIONS
  Transoral laser resection with the use of adjuvant radiotherapy in a minority of patients with adverse pathological findings can be recommended for the primary treatment of anterior commissure glottic cancer from an oncological perspective; excellent local control and laryngeal preservation rates can be achieved.
authors.affiliation: Division of Otolaryngology,Great Ormond Street Hospital,London,UK.
authors.forename: K A
authors.initials: KA
authors.lastname: Stephenson
authors.affiliation: Division of Otolaryngology,University of Cape Town,South Africa.
authors.forename: J J
authors.initials: JJ
authors.lastname: Fagan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D005931:Glottis / Q000601:surgery*; D006258:Head and Neck Neoplasms / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000601:surgery*; D007830:Larynx; D053685:Laser Therapy / Q000379:methods*; D054020:Lasers, Gas / Q000627:therapeutic use*; D008297:Male; D008866:Microsurgery / Q000379:methods*; D008875:Middle Aged; D009367:Neoplasm Staging; D059351:Organ Sparing Treatments; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D000077195:Squamous Cell Carcinoma of Head and Neck
keywords: Anterior Laryngeal Commissure; Laryngeal Cancer; Larynx; Laser; Radiotherapy