title: Feasibility of concomitant MitraClip and left atrial appendage occlusion.
abstract: OBJECTIVE
  The aim of our study is to report our single-centre experience with concomitant MitraClip (MC) and left atrial appendage occlusion (LAAO) and further to assess the feasibility, safety and short-term outcome of such an approach.
  
  
  RESULTS
  Twenty-five consecutive patients underwent MC with concomitant LAAO at our hospital (combined group). As a control group, 25 consecutive patients with atrial fibrillation (AF) undergoing standalone MC were selected. Baseline parameters were equal between the two groups. Patients in the combined group had longer procedural time (90.0 min vs. 66.0 min, p=0.02) and radiation time (32.0 min vs. 18.0 min, p=0.01). There were no procedural deaths. At 30 days, one patient died due to cerebral haemorrhage (combined vs.
  
  
  METHODS
  4% vs. 0%, p=0.32) and two had acute kidney injury (combined vs.
  
  
  METHODS
  4% vs. 4%, p=1.00). In multivariate analysis, the association of LAAO with device or procedural success was not significant.
  
  
  CONCLUSIONS
  LAAO along with MC in a single stage procedure is feasible. These preliminary results have to be validated in a large randomised study, in order to assess the efficacy of combined LAAO that can be expected to become evident only after longer follow-up.
authors.affiliation: University Heart Center, Zurich, Switzerland; 2. HerzZentrum Hirslanden, Zurich, Switzerland.
authors.forename: Shingo
authors.initials: S
authors.lastname: Kuwata
authors.forename: Maurizio
authors.initials: M
authors.lastname: Taramasso
authors.forename: Michel
authors.initials: M
authors.lastname: Zuber
authors.forename: Gabor
authors.initials: G
authors.lastname: Suetsch
authors.forename: Adrian
authors.initials: A
authors.lastname: Attinger-Toller
authors.forename: David
authors.initials: D
authors.lastname: Wicki
authors.forename: Francesco
authors.initials: F
authors.lastname: Maisano
authors.forename: Fabian
authors.initials: F
authors.lastname: Nietlispach
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D020517:Atrial Appendage / Q000503:physiopathology*; D001281:Atrial Fibrillation / Q000601:surgery*; D006328:Cardiac Catheterization / Q000379:methods; D017548:Echocardiography, Transesophageal / Q000379:methods; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D055989:Septal Occluder Device; D020521:Stroke / Q000209:etiology / Q000503:physiopathology; D013525:Surgical Instruments; D016896:Treatment Outcome