title: Rules of tissue packing involving different cell types: human muscle organization.
abstract: Natural packed tissues are assembled as tessellations of polygonal cells. These include skeletal muscles and epithelial sheets. Skeletal muscles appear as a mosaic composed of two different types of cells: the "slow" and "fast" fibres. Their relative distribution is important for the muscle function but little is known about how the fibre arrangement is established and maintained. In this work we capture the organizational pattern in two different healthy muscles: biceps brachii and quadriceps. Here we show that the biceps brachii muscle presents a particular arrangement, based on the different sizes of slow and fast fibres. By contrast, in the quadriceps muscle an unbiased distribution exists. Our results indicate that the relative size of each cellular type imposes an intrinsic organization into natural tessellations. These findings establish a new framework for the analysis of any packed tissue where two or more cell types exist.
authors.affiliation: Departamento de Biología Celular, Universidad de Sevilla and Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universdad de Sevilla, 41013 Seville, Spain.
authors.forename: Daniel
authors.initials: D
authors.lastname: Sánchez-Gutiérrez
authors.affiliation: Dpto. Teoría de la Señal y Comunicaciones. Universidad de Sevilla, Cmno, de los descubrimientos s/n, 41092, Sevilla, Spain.
authors.forename: Aurora
authors.initials: A
authors.lastname: Sáez
authors.affiliation: Departamento de Biología Celular, Universidad de Sevilla and Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universdad de Sevilla, 41013 Seville, Spain.
authors.forename: Pedro
authors.initials: P
authors.lastname: Gómez-Gálvez
authors.affiliation: Neuromuscular Disorders Unit, Department of Neurology, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universdad de Sevilla, 41013 Seville, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Paradas
authors.affiliation: Departamento de Biología Celular, Universidad de Sevilla and Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universdad de Sevilla, 41013 Seville, Spain.
authors.forename: Luis M
authors.initials: LM
authors.lastname: Escudero
mesh_terms: D001706:Biopsy; D006801:Humans; D007091:Image Processing, Computer-Assisted; D018485:Muscle Fibers, Skeletal / Q000473:pathology; D018482:Muscle, Skeletal / Q000473:pathology*; D025341:Principal Component Analysis