title: Effect of Cynomorium total flavone on depression model of perimenopausal rat.
abstract: OBJECTIVE
  To observe the effect of cynomorium total flavone on the depression model of perimenopausal rat and to analyze the action characteristics of cynomorium total flavone on depression of rat with perimenopausal syndrome.
  
  
  METHODS
  Duplicate the model of rat with perimenopausal depression based on the combined method of incomplete castration and chronic stimulation, and keep drug administration for 35d. And then measure related behavior indicators and the change of biochemical index level in serum and brains; measure the estrogen/androgen receptor (ER/AR) in related tissues and the ERmRNA expression in hypothalamus.
  
  
  RESULTS
  It can be seen that cynomorium total flavone can significantly improve the behavior indicators of rat with perimenopausal depression; obviously or significantly change the level of related biomedical indexes in serum and brains of perimenopausal depressed rat; obviously or significantly increase the expression of ER/AR in related tissues of perimenopausal depressed rat; obviously or significantly increase the ERmRNA expression in hypothalamus.
  
  
  CONCLUSIONS
  Cynomorium total flavone can adjust hypothalamic-pituitary-gonadal axis by increasing E2, and make related biomedical indexes and hormone receptors tend to be normal, so as to relieve perimenopausal syndrome and perimenopausal syndrome with depression.
authors.affiliation: Henan University of Traditional Chinese Medicine, Zhengzhou 450008, China.
authors.forename: Mingsan
authors.initials: M
authors.lastname: Miao
authors.affiliation: Henan University of Traditional Chinese Medicine, Zhengzhou 450008, China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Yan
authors.affiliation: Henan University of Traditional Chinese Medicine, Zhengzhou 450008, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Guo
authors.affiliation: Henan University of Traditional Chinese Medicine, Zhengzhou 450008, China.
authors.forename: Pengfei
authors.initials: P
authors.lastname: Li
keywords: Cynomorium total flavone; Estradiol; Estrogen receptor; Perimenopausal syndrome with depression