title: Impact of Probiotic Administration on Serum C-Reactive Protein Concentrations: Systematic Review and Meta-Analysis of Randomized Control Trials.
abstract: We conducted this systematic review and meta-analysis of prospective studies to determine the effect of probiotic administration on serum C-reactive protein (CRP) concentrations. We searched PubMed-Medline, Web of Science, the Cochrane, and Google Scholar databases (until May 2016) to identify prospective studies evaluating the impact of probiotic administration on CRP. We used a random effects models and generic inverse variance methods to synthesize quantitative data, followed by a leave-one-out method for sensitivity analysis. The systematic review registration number was: CRD42016039457. From a total of 425 entries identified via searches, 20 studies were included in the final analysis. The meta-analysis indicated a significant reduction in serum CRP following probiotic administration with a weighted mean difference (WMD) of -1.35 mg/L, (95% confidence interval (CI) -2.15 to -0.55,I² 65.1%). The WMDs for interleukin 10 (IL10) was -1.65 pg/dL, (95% CI -3.45 to 0.14,I² 3.1%), and -0.45 pg/mL, (95% CI -1.38 to 0.48,I² 10.2%) for tumor necrosis factor alpha (TNF-α). These findings were robust in sensitivity analyses. This meta-analysis suggests that probiotic administration may significantly reduce serum CRP while having no significant effect on serum IL10 and TNF-α.
authors.affiliation: Key State Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China. moshen@genetics.ac.cn.|Institute of Genetics and Developmental Biology, International College, University of Chinese Academy of Science, Beijing 100101, China. moshen@genetics.ac.cn.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Mazidi
authors.affiliation: Biochemistry and Nutrition Research Centre, School of Medicine, Mashhad University of Medical Science, Mashhad 42536, Iran. peymanrezaie.nutrition@gmail.com.
authors.forename: Peyman
authors.initials: P
authors.lastname: Rezaie
authors.affiliation: Division of Medical Education, Brighton and Sussex Medical School, Rm 342, Mayfield House, University of Brighton, Brighton BN1 9PH, UK. s.brown5@brighton.ac.uk.
authors.forename: Gordon A
authors.initials: GA
authors.lastname: Ferns
authors.affiliation: College of Pharmacy and Nutrition, University of Saskatchewan, Health Sciences E-Wing, 104 Clinic Place, Saskatoon, SK S7N 2Z4, Canada. vatan.h@usask.ca.
authors.forename: Hassan
authors.initials: H
authors.lastname: Vatanparast
mesh_terms: D002097:C-Reactive Protein / Q000378:metabolism*; D016208:Databases, Factual; D006801:Humans; D016753:Interleukin-10 / Q000097:blood; D019936:Probiotics / Q000008:administration & dosage*; D016032:Randomized Controlled Trials as Topic; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: C508609:IL10 protein, human; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D002097:C-Reactive Protein
keywords: C-reactive protein; meta-analysis; probiotic