title: Liquid chromatographic enantiomer separation of 1-naphthylamides of chiral acids using several amylose- and cellulose-derived chiral stationary phases.
abstract: The liquid chromatographic enantiomer separation of various chiral acids as 1-naphthylamides was performed using several chiral stationary phases (CSPs). The CSPs used in this study were six covalently bonded and four coated type CSPs derived from amylose and cellulose derivatives as chiral selectors. The degree of enantioseparation is affected by the structure of chiral acids and the CSPs used, which have different chiral selectors and types of immobilization. For the enantiomer resolution of chiral acids as 1-naphthylamide derivatives, the performance of the coated type Lux Cellulose-1 was superior to those of the other CSPs, except for 2-aryloxypropionic acid derivatives. Owing to the strong ultraviolet absorbance of the 1-naphthyl group, the convenient analytical method developed and validated in this study could be expected to be very useful for the enantiomer separation of various chiral acids as 1-naphthylamide derivatives using polysaccharide-derived CSPs.
authors.affiliation: College of Pharmacy, Chosun University, Gwangju, 501-759, Korea.
authors.forename: Md F
authors.initials: MF
authors.lastname: Islam
authors.affiliation: College of Pharmacy, Chosun University, Gwangju, 501-759, Korea.
authors.forename: Suraj
authors.initials: S
authors.lastname: Adhikari
authors.affiliation: College of Pharmacy, Sunchon National University, Sunchon, Jeonnam, 540-950, Korea. paik815@sunchon.ac.kr.
authors.forename: Man-Jeong
authors.initials: MJ
authors.lastname: Paik
authors.affiliation: College of Pharmacy, Chosun University, Gwangju, 501-759, Korea. wlee@chosun.ac.kr.
authors.forename: Wonjae
authors.initials: W
authors.lastname: Lee
mesh_terms: D000688:Amylose / Q000737:chemistry*; D002482:Cellulose / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D007052:Ibuprofen / Q000737:chemistry / Q000302:isolation & purification; D009281:Naphthalenes / Q000737:chemistry* / Q000302:isolation & purification*; D015203:Reproducibility of Results; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism
chemical_list: D009281:Naphthalenes; C072587:2-naphthylamide; D002482:Cellulose; D000688:Amylose; D007052:Ibuprofen
keywords: 1-Naphthylamide derivative; Chiral acid; Chiral stationary phase; Enantiomer separation