title: Surveillance for Secure Differentiation.
abstract: The precise place and time where embryonic differentiation begins is regulated by regionalized signaling. In this issue of Cell Stem Cell, Wang et al. (2017) investigate how converging Wnt and Nodal signals promote mesendoderm through a p53, Wnt3 feed-forward loop, pointing to a mechanism by which cells gauge time and fitness during differentiation.
authors.affiliation: The Danish Stem Cell Centre (DanStem), Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen N, Denmark.
authors.forename: William B
authors.initials: WB
authors.lastname: Hamilton
authors.affiliation: The Danish Stem Cell Centre (DanStem), Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen N, Denmark. Electronic address: joshua.brickman@sund.ku.dk.
authors.forename: Joshua M
authors.initials: JM
authors.lastname: Brickman
mesh_terms: D002454:Cell Differentiation; D053595:Embryonic Stem Cells / Q000166:cytology; D006801:Humans; D015398:Signal Transduction; D013234:Stem Cells / Q000166:cytology; D051153:Wnt Proteins
chemical_list: D051153:Wnt Proteins