title: Increased Malignant Microcalcifications after Neoadjuvant Chemotherapy in Advanced Breast Cancer.
abstract: In patients with advanced breast cancer, most new calcifications detected on a mammogram after neoadjuvant chemotherapy are benign dystrophic calcifications, but this is not always observed. We present a patient with advanced breast cancer who had paradoxically increased malignant microcalcifications concomitant with primary tumor regression after undergoing neoadjuvant chemotherapy. After the neoadjuvant chemotherapy, the follow-up mammogram revealed that local, fine pleomorphic microcalcifications had markedly increased. Pathologically, these calcifications were ductal carcinomain situ. We concluded that, in patients with breast cancer undergoing neoadjuvant chemotherapy, newly developed microcalcifications on follow-up mammograms should be carefully evaluated, and any suspicious malignant microcalcifications should be included in surgical excision planning.
authors.affiliation: Department of Radiology, Inje University Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.
authors.forename: Gi Won
authors.initials: GW
authors.lastname: Shin
authors.affiliation: Department of Radiology, Inje University Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.
authors.forename: Young Mi
authors.initials: YM
authors.lastname: Park
authors.affiliation: Department of Pathology, Inje University Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.
authors.forename: Hye Kyoung
authors.initials: HK
authors.lastname: Yoon
authors.affiliation: Department of Pathology, Inje University Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.
authors.forename: Soo Jin
authors.initials: SJ
authors.lastname: Jung
authors.affiliation: Department of Surgery, Inje University Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.
authors.forename: Tae Hyun
authors.initials: TH
authors.lastname: Kim
authors.affiliation: Department of Surgery, Inje University Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.
authors.forename: Anbok
authors.initials: A
authors.lastname: Lee
authors.affiliation: Department of Nuclear Medicine, Inje University Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.
authors.forename: Seok Mo
authors.initials: SM
authors.lastname: Lee
keywords: Breast neoplasms; Calcinosis; Mammography; Neoadjuvant therapy