title: Advances in Evaluation of Cognitive Impairment in Patients with Cushing's Disease.
abstract: Cushing's disease (CD) is a relatively rare disease,characterized by pathological hypercortisolism secondary to excessive adrenocorticotrophic hormone that is secreted by pituitary adrenocorticotrophic hormone adenoma or hyperplasia. In addition to the typical clinical symptoms such as moon face,buffalo hump,and central obesity,the CD patients may also experience mental disorders and cognitive dysfunction. This review mainly focuses on the cognitive state of CD patients,the mechanisms of cognitive impairment caused by high cortisol levels,and the imaging findings (especially magnetic resonance imaging) for the evaluation of cognitive functions.
authors.affiliation: Department of Radiology, PUMC Hospital, CAMS and PUMC,Beijing 100730,China.
authors.forename: Wei-Yu
authors.initials: WY
authors.lastname: Mao
authors.affiliation: Department of Radiology, PUMC Hospital, CAMS and PUMC,Beijing 100730,China.
authors.forename: Hui
authors.initials: H
authors.lastname: You
authors.affiliation: 2Department of Neurosurgery, PUMC Hospital, CAMS and PUMC,Beijing 100730,China.
authors.forename: Bing
authors.initials: B
authors.lastname: Xing
authors.affiliation: Department of Endocrinology,PUMC Hospital, CAMS and PUMC,Beijing 100730,China.
authors.forename: Hui-Juan
authors.initials: HJ
authors.lastname: Zhu
authors.affiliation: Department of Radiology, PUMC Hospital, CAMS and PUMC,Beijing 100730,China.
authors.forename: Feng
authors.initials: F
authors.lastname: Feng
mesh_terms: D000236:Adenoma / Q000150:complications; D003071:Cognition; D060825:Cognitive Dysfunction / Q000150:complications / Q000175:diagnosis*; D003480:Cushing Syndrome / Q000150:complications*; D006801:Humans; D006965:Hyperplasia; D008279:Magnetic Resonance Imaging; D047748:Pituitary ACTH Hypersecretion; D010911:Pituitary Neoplasms / Q000150:complications