title: Facile preparation of antibacterial, highly elastic silvered polyurethane nanofiber fabrics using silver carbamate and their dermal wound healing properties.
abstract: In this study, polycarbonate diol/isosorbide-based antibacterial polyurethane nanofiber fabrics containing Ag nanoparticles were prepared by electrospinning process. Bio-based highly elastic polyurethane was prepared from hexamethylene diisocyanate and isosorbide/polycarbonate diol (8/2) by a simple one-shot bulk polymerization. Ag nanoparticles were formed using simple thermal reduction of silver 2-ethylhexylcarbamate at 120℃. The structural and morphological properties of polyurethane/Ag nanofibers were characterized by X-ray diffraction and scanning electron microscopy. The polyurethane nanofiber fabrics were flexible, with breaking strains from 355% to 950% under 7.28 to 23.1 MPa tensile stress. The antibacterial effects of the treated polyurethane/Ag fabrics against Staphylococcus aureus and methicillin resistant Staphylococcus aureus were examined and found to be excellent. Cell proliferation using the immortalized human keratinocyte HaCaT cell line was performed in order to determine cell viability in the presence of polyurethane and polyurethane/Ag fabrics, showing cytocompatiblility and a lack of toxicity.
authors.affiliation: 1 Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center, Dankook University Graduate School, Gyeonggi-do, South Korea.
authors.forename: Suk-Min
authors.initials: SM
authors.lastname: Hong
authors.affiliation: 1 Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center, Dankook University Graduate School, Gyeonggi-do, South Korea.|2 Institute of Tissue Regeneration Engineering, Dankook University, Chungnam, South Korea.
authors.forename: Jong-Wan
authors.initials: JW
authors.lastname: Kim
authors.affiliation: 1 Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center, Dankook University Graduate School, Gyeonggi-do, South Korea.|3 Division of Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, University College London, London, UK.
authors.forename: Jonathan C
authors.initials: JC
authors.lastname: Knowles
authors.affiliation: 1 Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center, Dankook University Graduate School, Gyeonggi-do, South Korea.|2 Institute of Tissue Regeneration Engineering, Dankook University, Chungnam, South Korea.
authors.forename: Myoung-Seon
authors.initials: MS
authors.lastname: Gong
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D001458:Bandages; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D004339:Drug Compounding; D055119:Elastic Modulus; D004867:Equipment Design; D006801:Humans; D022125:Lacerations / Q000188:drug therapy* / Q000473:pathology; D008422:Materials Testing; D057139:Nanofibers / Q000737:chemistry*; D011140:Polyurethanes / Q000737:chemistry*; D012834:Silver / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000166:cytology / Q000187:drug effects*; D013718:Tensile Strength; D013784:Textiles; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D003692:Delayed-Action Preparations; D011140:Polyurethanes; D012834:Silver
keywords: Isosorbide; dermal wound healing; elastomeric polyurethane; electrospun nanofibers; silver carbamate; silver nanoparticles; thermal reduction