title: Micro-electromechanical film bulk acoustic sensor for plasma and whole blood coagulation monitoring.
abstract: Monitoring blood coagulation is an important issue in the surgeries and the treatment of cardiovascular diseases. In this work, we reported a novel strategy for the blood coagulation monitoring based on a micro-electromechanical film bulk acoustic resonator. The resonator was excited by a lateral electric field and operated under the shear mode with a frequency of 1.9GHz. According to the apparent step-ladder curves of the frequency response to the change of blood viscoelasticity, the coagulation time (prothrombin time) and the coagulation kinetics were measured with the sample consumption of only 1μl. The procoagulant activity of thromboplastin and the anticoagulant effect of heparin on the blood coagulation process were illustrated exemplarily. The measured prothrombin times showed a good linear correlation with R2=0.99969 and a consistency with the coefficient of variation less than 5% compared with the commercial coagulometer. The proposed film bulk acoustic sensor, which has the advantages of small size, light weight, low cost, simple operation and little sample consumption, is a promising device for miniaturized, online and automated analytical system for routine diagnostics of hemostatic status and personal health monitoring.
authors.affiliation: Mine Disaster Prevention and Control Key Laboratory of Education Ministry of China, Shandong University of Science and Technology, Qingdao 266590, China; College of Electronics, Communications, and Physics, Shandong University of Science and Technology, Qingdao 266590, PR China. Electronic address: phychenda@163.com.
authors.forename: Da
authors.initials: D
authors.lastname: Chen
authors.affiliation: College of Electronics, Communications, and Physics, Shandong University of Science and Technology, Qingdao 266590, PR China.
authors.forename: Shuren
authors.initials: S
authors.lastname: Song
authors.affiliation: College of Electronics, Communications, and Physics, Shandong University of Science and Technology, Qingdao 266590, PR China.
authors.forename: Jilong
authors.initials: J
authors.lastname: Ma
authors.affiliation: College of Electronics, Communications, and Physics, Shandong University of Science and Technology, Qingdao 266590, PR China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: College of Electronics, Communications, and Physics, Shandong University of Science and Technology, Qingdao 266590, PR China.
authors.forename: Peng
authors.initials: P
authors.lastname: Wang
authors.affiliation: College of Electronics, Communications, and Physics, Shandong University of Science and Technology, Qingdao 266590, PR China.
authors.forename: Weihui
authors.initials: W
authors.lastname: Liu
authors.affiliation: Mechanical & Materials Engineering, Western University, London, Ontario, Canada, N6A 3K7. Electronic address: qguo29@uwo.ca.
authors.forename: Qiuquan
authors.initials: Q
authors.lastname: Guo
mesh_terms: D000162:Acoustics / Q000295:instrumentation*; D015374:Biosensing Techniques / Q000295:instrumentation; D001777:Blood Coagulation; D001780:Blood Coagulation Tests / Q000295:instrumentation*; D001809:Blood Viscosity; D004867:Equipment Design; D006801:Humans; D055617:Micro-Electrical-Mechanical Systems / Q000295:instrumentation*
keywords: Acoustic resonator; Blood coagulation; Film bulk acoustic resonator; Micro-electromechanical system; Viscosity sensor