title: Guanosine 5'-monophosphate-chelated calcium and iron feed additives maintains egg production and preventsSalmonellaGallinarum in experimentally infected layers.
abstract: We evaluated the effects of guanosine 5'-monophosphate (GMP)-chelated calcium and iron (CaFe-GMP) on health and egg quality in layers experimentally infected withSalmonellaGallinarum. In this study, a CaFe-GMP feed additive was added to a commercial layer feed and fed to layers over a four-week period. All were inoculated withSalmonellaGallinarum. Body weight, mortality, clinical symptoms, and poultry production including feed intake, egg production, egg loss, and feed conversion rate were observed, andSalmonellaGallinarum was re-isolated from the liver, spleen, and cecum of the layers. All tested internal organs for the CaFe-GMP additive group exhibited significantly lower re-isolation numbers ofSalmonellaGallinarum and less severe pathological changes than those in the control group, indicating that the CaFe-GMP feed supplement induced bacterial clearance and increased resistance toSalmonellaGallinarum. Additionally, due to the inhibitory action of CaFe-GMP on the growth ofSalmonellaGallinarum, the CaFe-GMP additive group exhibited better egg production, including a higher laying rate and fewer broken eggs. The results suggest that a 0.16% CaFe-GMP additive may help prevent salmonellosis in the poultry industry.
authors.affiliation: Medinutrol Co., Ltd., Yeonggwang 57024, Korea.
authors.forename: Hye-Ji
authors.initials: HJ
authors.lastname: Noh
authors.affiliation: Medinutrol Co., Ltd., Yeonggwang 57024, Korea.
authors.forename: HeeKyong
authors.initials: H
authors.lastname: Kim
authors.affiliation: College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Korea.
authors.forename: Su Jeong
authors.initials: SJ
authors.lastname: Heo
authors.affiliation: Hanilbiomed Inc., Gwangju 62363, Korea.
authors.forename: Hyang Hyun
authors.initials: HH
authors.lastname: Cho
authors.affiliation: College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Korea.
authors.forename: Hong Bum
authors.initials: HB
authors.lastname: Koh
mesh_terms: D000821:Animal Feed; D000818:Animals; D002118:Calcium / Q000008:administration & dosage / Q000627:therapeutic use*; D065096:Calcium Chelating Agents / Q000627:therapeutic use; D002645:Chickens / Q000382:microbiology; D019587:Dietary Supplements; D005260:Female; D006157:Guanosine Monophosphate / Q000008:administration & dosage / Q000627:therapeutic use*; D007501:Iron / Q000008:administration & dosage / Q000627:therapeutic use*; D007502:Iron Chelating Agents / Q000627:therapeutic use; D010058:Oviposition / Q000187:drug effects*; D011201:Poultry Diseases / Q000382:microbiology / Q000517:prevention & control*; D012475:Salmonella; D012481:Salmonella Infections, Animal / Q000382:microbiology / Q000517:prevention & control*
chemical_list: D065096:Calcium Chelating Agents; D007502:Iron Chelating Agents; D006157:Guanosine Monophosphate; D007501:Iron; D002118:Calcium
keywords: Salmonella Gallinarum; feed additives; layer; organic mineral