title: A biomimetic mesh for treating female stress urinary incontinence.
abstract: For patients with medium to severe incontinence, sub-urethral support surgery has a high cure rate, but using synthetic meshes leads to some complications such as mesh erosion/exposure and thigh pain. Autologous or acellular extracellular matrix grafts present few complications but have a high recurrence rate. Regensling™is a new sling product made of a synthetic material with a biomimetic structure, aiming to provide long-term mechanical support with a lower complication rate. To assess the safety and effectiveness of Regensling™, both in vitro and in vivo experiments were performed. The mesh was implanted in the subcutaneous, intramuscular and sub-urethral regions of rabbits. At 4, 12, and 26 weeks post-implantation, the animals were executed and the implants were studied for their mechanical and biocompatible properties. Compared to the control material, the Regensling™was covered by a thin layer of fibrous tissue with good compliance, and had a milder inflammatory response. During the period of the experiment, Regensling™showed stable strength with an increasing trend over time.
authors.affiliation: School of Bioscience & Bioengineering, South China University of Technology, Guangzhou, People's Republic of China.
authors.forename: Kuilin
authors.initials: K
authors.lastname: Lai
authors.forename: Jiazhen
authors.initials: J
authors.lastname: Zhang
authors.forename: Guoshuai
authors.initials: G
authors.lastname: Wang
authors.forename: Xin
authors.initials: X
authors.lastname: Luo
authors.forename: Man
authors.initials: M
authors.lastname: Liu
authors.forename: Xinzhi
authors.initials: X
authors.lastname: Zhang
authors.forename: Yuyu
authors.initials: Y
authors.lastname: Yuan
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.forename: Tao
authors.initials: T
authors.lastname: Xu
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000627:therapeutic use* / Q000633:toxicity; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D005260:Female; D020007:Implants, Experimental; D051379:Mice; D011817:Rabbits; D012720:Severity of Illness Index; D013718:Tensile Strength; D001743:Urinary Bladder / Q000473:pathology; D014550:Urinary Incontinence, Stress / Q000473:pathology / Q000628:therapy* / Q000662:veterinary
chemical_list: D001672:Biocompatible Materials