title: Resveratrol, Potential Therapeutic Interest in Joint Disorders: A Critical Narrative Review.
abstract: Trans-resveratrol (t-Res) is a natural compound of a family of hydroxystilbenes found in a variety of spermatophyte plants. Because of its effects on lipids and arachidonic acid metabolisms, and its antioxidant activity, t-Res is considered as the major cardioprotective component of red wine, leading to the "French Paradox" health concept. In the past decade, research on the effects of resveratrol on human health has developed considerably in diverse fields such as cancer, neurodegenerative and cardiovascular diseases, and metabolic disorders. In the field of rheumatic disorders, in vitro evidence suggest anti-inflammatory, anti-catabolic, anti-apoptotic and anti-oxidative properties of t-Res in various articular cell types, including chondrocytes and synoviocytes, along with immunomodulation properties on T and B lymphocytes. In preclinical models of osteoarthritis and rheumatoid arthritis, resveratrol has shown joint protective effects, mainly mediated by decreased production of pro-inflammatory and pro-degradative soluble factors, and modulation of cellular and humoral responses. Herein, we comprehensively reviewed evidence supporting a potential therapeutic interest of t-Res in treating symptoms related to rheumatic disorders.
authors.affiliation: Université Paris Descartes, Sorbonne Paris Cité, Paris 75006, France. christelle.nguyen2@aphp.fr.|INSERM UMR 1124, Faculté des Sciences Fondamentales et Biomédicales, Laboratoire de Pharmacologie, Toxicologie et Signalisation Cellulaire, UFR Biomédicale des Saints Pères, Paris 75006, France. christelle.nguyen2@aphp.fr.|Service de Rééducation et de Réadaptation de l'Appareil Locomoteur et des Pathologies du Rachis, Hôpitaux Universitaires-Paris Centre, Groupe Hospitalier Cochin, Assistance Publique-Hôpitaux de Paris, Paris 75014, France. christelle.nguyen2@aphp.fr.
authors.forename: Christelle
authors.initials: C
authors.lastname: Nguyen
authors.affiliation: Université Paris Descartes, Sorbonne Paris Cité, Paris 75006, France. jean-francois.savouret@parisdescartes.fr.|INSERM UMR 1124, Faculté des Sciences Fondamentales et Biomédicales, Laboratoire de Pharmacologie, Toxicologie et Signalisation Cellulaire, UFR Biomédicale des Saints Pères, Paris 75006, France. jean-francois.savouret@parisdescartes.fr.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Savouret
authors.affiliation: Université Paris Descartes, Sorbonne Paris Cité, Paris 75006, France. marie-therese.corvol@parisdescartes.fr.|INSERM UMR 1124, Faculté des Sciences Fondamentales et Biomédicales, Laboratoire de Pharmacologie, Toxicologie et Signalisation Cellulaire, UFR Biomédicale des Saints Pères, Paris 75006, France. marie-therese.corvol@parisdescartes.fr.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Widerak
authors.affiliation: Université Paris Descartes, Sorbonne Paris Cité, Paris 75006, France. francois.rannou@aphp.fr.|INSERM UMR 1124, Faculté des Sciences Fondamentales et Biomédicales, Laboratoire de Pharmacologie, Toxicologie et Signalisation Cellulaire, UFR Biomédicale des Saints Pères, Paris 75006, France. francois.rannou@aphp.fr.
authors.forename: Marie-Thérèse
authors.initials: MT
authors.lastname: Corvol
authors.affiliation: Université Paris Descartes, Sorbonne Paris Cité, Paris 75006, France.|INSERM UMR 1124, Faculté des Sciences Fondamentales et Biomédicales, Laboratoire de Pharmacologie, Toxicologie et Signalisation Cellulaire, UFR Biomédicale des Saints Pères, Paris 75006, France.|Service de Rééducation et de Réadaptation de l'Appareil Locomoteur et des Pathologies du Rachis, Hôpitaux Universitaires-Paris Centre, Groupe Hospitalier Cochin, Assistance Publique-Hôpitaux de Paris, Paris 75014, France.
authors.forename: François
authors.initials: F
authors.lastname: Rannou
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D001682:Biological Availability; D004195:Disease Models, Animal; D006801:Humans; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D013267:Stilbenes; D000077185:Resveratrol
keywords: aryl hydrocarbon receptor; chondrocyte; inflammation; osteoarthritis; pain; rheumatoid arthritis; synoviocytes; trans-resveratrol