title: Home remodeling and risk of childhood leukemia.
abstract: OBJECTIVE
  We investigated the relationship between the risk of childhood leukemia and home remodeling, a surrogate for indoor chemical exposures.
  
  
  METHODS
  We collected information on remodeling activities carried out between birth and diagnosis in homes of 609 acute lymphoblastic leukemia (ALL) cases, 89 acute myeloid leukemia (AML) cases, and 893 matched controls participating in the California Childhood Leukemia Study (1995-2008). We used multivariable logistic regression to estimate the risk of ALL and AML associated with six remodeling activities: construction, painting, recarpeting, reflooring, roofing, and weatherproofing. Models were adjusted for age, sex, Hispanic ethnicity, race, household annual income, and residential mobility.
  
  
  RESULTS
  Construction in the home between birth and diagnosis was associated with a significant increase in ALL risk (odds ratio [OR]: 1.52, 95% confidence interval [CI]: 1.14-2.02) and a nonsignificant increase in AML risk (OR: 1.75, 95% CI: 0.98-3.15). No other remodeling activities were associated with ALL or AML risk in the main analysis. When stratifying by Hispanic ethnicity, a positive relationship between ALL risk and painting was evident in Hispanic children (OR: 1.47, 95% CI: 1.04-2.07).
  
  
  CONCLUSIONS
  Specific home remodeling activities appeared to be associated with increased risk of childhood ALL.
authors.affiliation: School of Public Health, University of California, Berkeley. Electronic address: ToddPWhitehead@Berkeley.edu.
authors.forename: Todd P
authors.initials: TP
authors.lastname: Whitehead
authors.affiliation: School of Public Health, University of California, Berkeley.
authors.forename: Praphopphat
authors.initials: P
authors.lastname: Adhatamsoontra
authors.affiliation: School of Public Health, University of California, Berkeley.
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Diagnostic, Clinical and Public Health Medicine, University of Modena and Reggio Emilia, Modena, Italy.
authors.forename: Elisa
authors.initials: E
authors.lastname: Arcolin
authors.affiliation: School of Medicine, University of California, Irvine.
authors.forename: Leonard
authors.initials: L
authors.lastname: Sender
authors.affiliation: School of Public Health, University of California, Berkeley.
authors.forename: Steve
authors.initials: S
authors.lastname: Selvin
authors.affiliation: School of Public Health, University of California, Berkeley.
authors.forename: Catherine
authors.initials: C
authors.lastname: Metayer
mesh_terms: D000293:Adolescent; D016902:Air Pollution, Indoor / Q000009:adverse effects* / Q000706:statistics & numerical data*; D002140:California; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003252:Construction Materials / Q000009:adverse effects*; D004781:Environmental Exposure / Q000009:adverse effects* / Q000706:statistics & numerical data*; D005006:Ethnicity / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D007223:Infant; D015470:Leukemia, Myeloid, Acute / Q000209:etiology*; D016015:Logistic Models; D008297:Male; D016017:Odds Ratio; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000209:etiology*; D012307:Risk Factors
keywords: Childhood acute lymphoblastic leukemia; Childhood acute myeloid leukemia; Construction materials; Environmental exposures