title: Diagnosis of Alzheimer's Disease Using View-Aligned Hypergraph Learning with Incomplete Multi-modality Data.
abstract: Effectively utilizing incomplete multi-modality data for diagnosis of Alzheimer's disease (AD) is still an area of active research. Several multi-view learning methods have recently been developed to deal with missing data, with each view corresponding to a specific modality or a combination of several modalities. However, existing methods usually ignore the underlying coherence among views, which may lead to suboptimal learning performance. In this paper, we propose a view-aligned hypergraph learning (VAHL) method to explicitly model the coherence among the views. Specifically, we first divide the original data into several views based on possible combinations of modalities, followed by a sparse representation based hypergraph construction process in each view. A view-aligned hypergraph classification (VAHC) model is then proposed, by using a view-aligned regularizer to model the view coherence. We further assemble the class probability scores generated from VAHC via a multi-view label fusion method to make a final classification decision. We evaluate our method on the baseline ADNI-1 database having 807 subjects and three modalities (i.e., MRI, PET, and CSF). Our method achieves at least a 4.6% improvement in classification accuracy compared with state-of-the-art methods for AD/MCI diagnosis.
authors.affiliation: Department of Radiology and BRIC, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
authors.forename: Mingxia
authors.initials: M
authors.lastname: Liu
authors.affiliation: Department of Radiology and BRIC, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Radiology and BRIC, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
authors.forename: Pew-Thian
authors.initials: PT
authors.lastname: Yap
authors.affiliation: Department of Radiology and BRIC, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
authors.forename: Dinggang
authors.initials: D
authors.lastname: Shen
mesh_terms: D000465:Algorithms; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid / Q000000981:diagnostic imaging*; D019540:Area Under Curve; D060825:Cognitive Dysfunction / Q000134:cerebrospinal fluid / Q000000981:diagnostic imaging*; D016208:Databases, Factual; D018450:Disease Progression; D006801:Humans; D000069550:Machine Learning; D008279:Magnetic Resonance Imaging; D064847:Multimodal Imaging / Q000379:methods*; D049268:Positron-Emission Tomography; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity