title: Critical Size Bone Defect Healing Using Collagen-Calcium Phosphate Bone Graft Materials.
abstract: The need for bone graft materials to fill bony voids or gaps that are not related to the intrinsic stability of the bone that arise due to trauma, tumors or osteolysis remains a clinically relevant and significant issue. The in vivo response of collagen-tricalcium phosphate bone graft substitutes was evaluated in a critical size cancellous defect model in skeletally mature rabbits. While the materials were chemically virtually identical, new bone formation, implant resorption and local in vivo responses were significantly different. Differences in the in vivo response may be due, in part, collagen source and processing which influences resorption profiles. Continued improvements in processing and manufacturing techniques of collagen-tricalcium phosphate bone graft substitutes can result in osteoconductive materials that support healing of critical size bone defects even in challenging pre-clinical models.
authors.affiliation: Surgical & Orthopaedic Research Laboratories, Prince of Wales Clinical School, UNSW Australia, Prince of Wales Hospital, Sydney, NSW, Australia.
authors.forename: William Robert
authors.initials: WR
authors.lastname: Walsh
authors.affiliation: Surgical & Orthopaedic Research Laboratories, Prince of Wales Clinical School, UNSW Australia, Prince of Wales Hospital, Sydney, NSW, Australia.
authors.forename: Rema A
authors.initials: RA
authors.lastname: Oliver
authors.affiliation: Surgical & Orthopaedic Research Laboratories, Prince of Wales Clinical School, UNSW Australia, Prince of Wales Hospital, Sydney, NSW, Australia.
authors.forename: Chris
authors.initials: C
authors.lastname: Christou
authors.affiliation: Surgical & Orthopaedic Research Laboratories, Prince of Wales Clinical School, UNSW Australia, Prince of Wales Hospital, Sydney, NSW, Australia.
authors.forename: Vedran
authors.initials: V
authors.lastname: Lovric
authors.affiliation: Surgical & Orthopaedic Research Laboratories, Prince of Wales Clinical School, UNSW Australia, Prince of Wales Hospital, Sydney, NSW, Australia.
authors.forename: Emma Rose
authors.initials: ER
authors.lastname: Walsh
authors.affiliation: Haider Biologics, San Diego, California, United States of America.
authors.forename: Gustavo R
authors.initials: GR
authors.lastname: Prado
authors.affiliation: Haider Biologics, San Diego, California, United States of America.
authors.forename: Thomas
authors.initials: T
authors.lastname: Haider
mesh_terms: D000818:Animals; D001861:Bone Regeneration; D001862:Bone Resorption; D018786:Bone Substitutes; D016025:Bone Transplantation; D002130:Calcium Phosphates / Q000737:chemistry*; D003094:Collagen / Q000737:chemistry*; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging; D017102:Fracture Healing; D050723:Fractures, Bone; D007249:Inflammation; D008855:Microscopy, Electron, Scanning; D011817:Rabbits; D054457:Tissue Scaffolds; D055114:X-Ray Microtomography
chemical_list: D018786:Bone Substitutes; D002130:Calcium Phosphates; D003094:Collagen; C018392:tricalcium phosphate