title: Fetal Brain Anomalies Associated with Ventriculomegaly or Asymmetry: An MRI-Based Study.
abstract: Fetal lateral ventriculomegaly is a relatively common finding with much debate over its clinical significance. The purpose of this study was to examine the association between ventriculomegaly and asymmetry and concomitant CNS findings as seen in fetal brain MR imaging.
  
  
  
  Fetal brain MR imaging performed for various indications, including ventriculomegaly, with or without additional ultrasound findings, was assessed for possible inclusion. Two hundred seventy-eight cases found to have at least 1 lateral ventricle with a width of ≥10 mm were included in the study. Ventriculomegaly was considered mild if the measurement was 10-11.9 mm; moderate if, 12-14.9 mm; and severe if, ≥15 mm. Asymmetry was defined as a difference of ≥2 mm between the 2 lateral ventricles. Fetal brain MR imaging findings were classified according to severity by predefined categories.
  
  
  
  The risk of CNS findings appears to be strongly related to the width of the ventricle (OR, 1.38; 95% CI, 1.08-1.76;P= .009). The prevalence of associated CNS abnormalities was significantly higher (P= .005) in symmetric ventriculomegaly compared with asymmetric ventriculomegaly (38.8% versus 24.2%, respectively, for all CNS abnormalities and 20% versus 7.1%, respectively, for major CNS abnormalities).
  
  
  
  In this study, we demonstrate that the rate of minor and major findings increased with each millimeter increase in ventricle width and that the presence of symmetric ventricles in mild and moderate ventriculomegaly was a prognostic indicator for CNS abnormalities.
authors.affiliation: From the Department of Obstetrics and Gynecology (E.B., R.A., E.K.) eran.barzilay@gmail.com.|Sackler School of Medicine (E.B., O.B.-Y., S.D., R.A., E.K.), Tel Aviv University, Tel Aviv, Israel.
authors.forename: E
authors.identifier: 0000-0001-5496-4866
authors.initials: E
authors.lastname: Barzilay
authors.affiliation: Pediatric Neurology Unit (O.B.-Y.), Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Israel.|Sackler School of Medicine (E.B., O.B.-Y., S.D., R.A., E.K.), Tel Aviv University, Tel Aviv, Israel.
authors.forename: O
authors.identifier: 0000-0002-7052-5238
authors.initials: O
authors.lastname: Bar-Yosef
authors.affiliation: Sackler School of Medicine (E.B., O.B.-Y., S.D., R.A., E.K.), Tel Aviv University, Tel Aviv, Israel.
authors.forename: S
authors.identifier: 0000-0002-4209-7459
authors.initials: S
authors.lastname: Dorembus
authors.affiliation: From the Department of Obstetrics and Gynecology (E.B., R.A., E.K.).|Sackler School of Medicine (E.B., O.B.-Y., S.D., R.A., E.K.), Tel Aviv University, Tel Aviv, Israel.
authors.forename: R
authors.identifier: 0000-0002-8294-3672
authors.initials: R
authors.lastname: Achiron
authors.affiliation: From the Department of Obstetrics and Gynecology (E.B., R.A., E.K.).|Sackler School of Medicine (E.B., O.B.-Y., S.D., R.A., E.K.), Tel Aviv University, Tel Aviv, Israel.
authors.forename: E
authors.identifier: 0000-0003-4225-7421
authors.initials: E
authors.lastname: Katorza
mesh_terms: D000328:Adult; D001921:Brain / Q000002:abnormalities* / Q000000981:diagnostic imaging* / Q000473:pathology; D002493:Central Nervous System Diseases / Q000000981:diagnostic imaging; D002552:Cerebral Ventricles / Q000000981:diagnostic imaging* / Q000473:pathology; D003430:Cross-Sectional Studies; D005260:Female; D005333:Fetus / Q000002:abnormalities* / Q000000981:diagnostic imaging* / Q000473:pathology; D007839:Functional Laterality; D006801:Humans; D007231:Infant, Newborn; D020547:Lateral Ventricles / Q000002:abnormalities; D008279:Magnetic Resonance Imaging; D011247:Pregnancy; D011379:Prognosis; D012189:Retrospective Studies; D016216:Ultrasonography, Prenatal