title: Modeling Radiotherapy Induced Normal Tissue Complications: An Overview beyond Phenomenological Models.
abstract: An overview of radiotherapy (RT) induced normal tissue complication probability (NTCP) models is presented. NTCP models based on empirical and mechanistic approaches that describe a specific radiation induced late effect proposed over time for conventional RT are reviewed with particular emphasis on their basic assumptions and related mathematical translation and their weak and strong points.
authors.affiliation: Laboratory of Medical Physics and Expert Systems, Regina Elena National Cancer Institute, Rome, Italy.
authors.forename: Marco
authors.identifier: 0000-0003-0517-6163
authors.initials: M
authors.lastname: D'Andrea
authors.affiliation: Laboratory of Medical Physics and Expert Systems, Regina Elena National Cancer Institute, Rome, Italy.
authors.forename: Marcello
authors.initials: M
authors.lastname: Benassi
authors.affiliation: Laboratory of Medical Physics and Expert Systems, Regina Elena National Cancer Institute, Rome, Italy.
authors.forename: Lidia
authors.initials: L
authors.lastname: Strigari
mesh_terms: D000465:Algorithms; D006801:Humans; D008962:Models, Theoretical; D016012:Poisson Distribution; D011336:Probability; D011832:Radiation Injuries; D011853:Radiobiology / Q000379:methods; D011878:Radiotherapy / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*