title: Clinical Relationship between Cholestatic Disease and Pituitary-Dependent Hyperadrenocorticism in Dogs: A Retrospective Case Series.
abstract: BACKGROUND
  A high prevalence of cholestatic disease, including gallbladder mucocele (GBM), has been reported in dogs with naturally occurring pituitary-dependent hyperadrenocorticism (PDH).
  
  
  OBJECTIVE
  Differences exist in the clinical features of dogs with PDH and concurrent cholestatic disease, and also is the management of these dogs with trilostane.
  
  
  METHODS
  Sixty-five client-owned dogs with naturally occurring PDH.
  
  
  METHODS
  This was a retrospective, observational case series. Each dog was treated with trilostane for at least 3 months before the study, and had a good clinical response, as determined by owners. Statistical comparisons of clinical signs, results of routine blood tests, basal and post-ACTH cortisol concentration, and optimal trilostane dosage were made after dogs were separated into the following 3 groups by ultrasonographic imaging: normal on ultrasound (NOU) group, cholestasis group, and GBM group.
  
  
  RESULTS
  The GBM group had more severe clinical signs and significantly different total serum cholesterol concentration and post-ACTH stimulation cortisol concentration at the time of diagnosis. Dogs that weighed <6 kg had a significantly higher prevalence of cholestatic disease than did the other dogs (P = .003). The optimal trilostane dosages for the GBM and cholestasis groups were 2.5 and 1.5 times the dosage of the NOU group, respectively (P < .001).
  
  
  CONCLUSIONS
  Gallbladder disease associated with cholestatic disease is correlated with PDH in dogs, in both its clinical features and drug management. These findings may be associated with hypercholesterolemia, unidentified genetic factors, and the hydrophobic nature of trilostane.
authors.affiliation: Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea.
authors.forename: K-H
authors.initials: KH
authors.lastname: Kim
authors.affiliation: Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea.
authors.forename: S-M
authors.initials: SM
authors.lastname: Han
authors.affiliation: Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea.
authors.forename: K-O
authors.initials: KO
authors.lastname: Jeon
authors.affiliation: Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea.
authors.forename: H-T
authors.identifier: http://orcid.org/0000-0001-5124-7976
authors.initials: HT
authors.lastname: Kim
authors.affiliation: Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea.
authors.forename: Q
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea.
authors.forename: M-O
authors.initials: MO
authors.lastname: Ryu
authors.affiliation: Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea.
authors.forename: W-J
authors.initials: WJ
authors.lastname: Song
authors.affiliation: Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea.
authors.forename: S-C
authors.initials: SC
authors.lastname: Park
authors.affiliation: Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea.
authors.forename: H-Y
authors.initials: HY
authors.lastname: Youn
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D001835:Body Weight; D013196:Dihydrotestosterone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004283:Dog Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology*; D004285:Dogs; D005260:Female; D005705:Gallbladder Diseases / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000662:veterinary*; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D009078:Mucocele / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000662:veterinary*; D047748:Pituitary ACTH Hypersecretion / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology / Q000662:veterinary*; D012189:Retrospective Studies
chemical_list: D013196:Dihydrotestosterone; D000324:Adrenocorticotropic Hormone; C009954:trilostane; D006854:Hydrocortisone
keywords: Cholesterol; Female; Mucocele; Trilostane