title: Critical role of tedizolid in the treatment of acute bacterial skin and skin structure infections.
abstract: Tedizolid phosphate has high activity against the Gram-positive microorganisms mainly involved in acute bacterial skin and skin structure infections, such as strains ofStaphylococcus aureus(including methicillin-resistantS. aureusstrains and methicillin-sensitiveS. aureusstrains),Streptococcus pyogenes,Streptococcus agalactiae, theStreptococcus anginosusgroup, andEnterococcus faecalis, including those with some mechanism of resistance limiting the use of linezolid. The area under the curve for time 0-24 hours/minimum inhibitory concentration (MIC) pharmacodynamic ratio has shown the best correlation with the efficacy of tedizolid, versus the time above MIC ratio and the maximum drug concentration/minimum inhibitory concentration ratio. Administration of this antibiotic for 6 days has shown its noninferiority versus administration of linezolid for 10 days in patients with skin and skin structure infections enrolled in two Phase III studies (ESTABLISH-1 and ESTABLISH-2). Tedizolid's more favorable safety profile and dosage regimen, which allow once-daily administration, versus linezolid, position it as a good therapeutic alternative. However, whether or not the greater economic cost associated with this antibiotic is offset by its shorter treatment duration and possibility of oral administration in routine clinical practice has yet to be clarified.
authors.affiliation: Hospital Pharmacy, Hospital Universitari del Mar, Barcelona, Spain; Nursing Department, Universitat Pompeu Fabra, Barcelona, Spain.
authors.forename: Olivia
authors.initials: O
authors.lastname: Ferrández
authors.affiliation: Hospital Pharmacy, Hospital Universitari del Mar, Barcelona, Spain.
authors.forename: Olatz
authors.initials: O
authors.lastname: Urbina
authors.affiliation: Hospital Pharmacy, Hospital Universitari del Mar, Barcelona, Spain; Medicine Department, Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Santiago
authors.initials: S
authors.lastname: Grau
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D013293:Enterococcus faecalis / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D023303:Oxazolidinones / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D017192:Skin Diseases, Bacterial / Q000188:drug therapy* / Q000382:microbiology*; D013291:Streptococcus / Q000187:drug effects; D013777:Tetrazoles / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D013777:Tetrazoles; C546016:tedizolid
keywords: acute bacterial skin and skin structure infections; linezolid resistance; oxazolidinone; tedizolid; tedizolid phosphate