title: From genome to proteome: Looking beyond DNA and RNA in chronic lymphocytic leukemia.
abstract: Chronic lymphocytic leukemia (CLL) remains the most common leukemia in the Western world. Whilst its disease course is extremely heterogeneous (ranging from indolent to aggressive), current methods are unable to accurately predict the clinical journey of each patient. There is clearly a pressing need for both improved prognostication and treatment options for patients with this disease. Whilst molecular studies have analyzed both genetic mutations and gene expression profiles of these malignant B-cells, and as a result have shed light on the pathogenesis of CLL, proteomic studies have been largely overlooked to date. This review summarizes our current knowledge of the proteomics of CLL, and discusses some of the issues in CLL proteomic research, such as reproducibility and data interpretation. In addition, we look ahead to how proteomics may significantly help in the development of a successful treatment for this currently incurable disease.
authors.affiliation: Department of Haematology and Genetic Pathology, Flinders University, Adelaide, South Australia, Australia. Electronic address: lauren.thurgood@flinders.edu.au.
authors.forename: Lauren A
authors.initials: LA
authors.lastname: Thurgood
authors.affiliation: Department of Physiology, Flinders University, Adelaide, South Australia, Australia.
authors.forename: Tim K
authors.initials: TK
authors.lastname: Chataway
authors.affiliation: Department of Haematology and Genetic Pathology, Flinders University, Adelaide, South Australia, Australia.
authors.forename: Karen M
authors.initials: KM
authors.lastname: Lower
authors.affiliation: Department of Haematology and Genetic Pathology, Flinders University, Adelaide, South Australia, Australia.
authors.forename: Bryone J
authors.initials: BJ
authors.lastname: Kuss
mesh_terms: D004273:DNA, Neoplasm / Q000235:genetics / Q000378:metabolism; D005260:Female; D015894:Genome, Human; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics / Q000378:metabolism; D008297:Male; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism; D020543:Proteome / Q000235:genetics / Q000378:metabolism; D040901:Proteomics; D012334:RNA, Neoplasm / Q000235:genetics / Q000378:metabolism
chemical_list: D004273:DNA, Neoplasm; D009363:Neoplasm Proteins; D020543:Proteome; D012334:RNA, Neoplasm
keywords: Chronic lymphocytic leukemia; MEC-1; Mass spectrometry; Proteomics