title: Association between thyroid hormone parameters and dyslipidemia among type 2 diabetes mellitus patients: Comparative cross-sectional study.
abstract: BACKGROUND
  The relationship between thyroid function and lipid profile has been documented in T2DM and healthy subjects. The aim of the current study was to assess the association between thyroid hormone parameters and dyslipidemia in T2DM and non-diabetic study participants.
  
  
  METHODS
  In this comparative cross-sectional study, 214 type 2 diabetic and 214 non-diabetic study participants were enrolled. Clinical and anthropometric data were collected from all study participants. After overnight fasting, 10ml of whole blood samples were drawn for the measurement of serum TSH, free thyroxine (fT4), free triiodothyronine (fT3), serum reactive C-protein levels, as well as for lipid profile test and glucose.
  
  
  RESULTS
  The burden of hypothyroidism and subclinical hypothyroidism among T2DM study participants were 73 (17.05%) and 13 (3.04%) respectively. Comparatively, T2DM study participants had significantly higher serum lipid level than non-diabetics. Stratified by TSH, hypothyroid T2DM study participants had increased lipid level than euthyroid subjects. T2DM serum TSH have shown a positive significant correlation with all lipid profile parameters except HDL-C. In the final model (multivariate linear regression), diabetics serum TSH significantly and positively associated with TG and BMI. Diabetic serum fT3 and fT4 negatively associated with body mass index. In addition, diabetics serum fT3 negatively and serum fT4 positively associated with TC and HDL-C respectively.
  
  
  CONCLUSIONS
  T2DM study subjects had significantly higher lipid level than nondiabetic and We identified that TSH was positively associated with serum TG and BMI among T2DM study participants.
authors.affiliation: Department of Medical Physiology, College of Health Sciences, Jimma University, Jimma, Ethiopia. Electronic address: amaju2002@yahoo.com.
authors.forename: Amare Desalegn
authors.initials: AD
authors.lastname: Wolide
authors.affiliation: Department of Medical Biochemistry, College of Health Sciences, Jimma University, Jimma, Ethiopia.
authors.forename: Belay
authors.initials: B
authors.lastname: Zawdie
authors.affiliation: Department of Human Anatomy, College of Health Sciences, Jimma University, Jimma, Ethiopia.
authors.forename: Tilahun
authors.initials: T
authors.lastname: Alemayehu
authors.affiliation: Department of Medical Physiology, College of Health Sciences, Jimma University, Jimma, Ethiopia.
authors.forename: Samuel
authors.initials: S
authors.lastname: Tadesse
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications* / Q000473:pathology; D050171:Dyslipidemias / Q000097:blood / Q000209:etiology* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000209:etiology* / Q000473:pathology; D008875:Middle Aged; D011379:Prognosis; D013963:Thyroid Hormones / Q000097:blood*; D055815:Young Adult
chemical_list: D013963:Thyroid Hormones
keywords: Diabetes; Dyslipidemia; Euthyroid; Hyperthyroid; Hypothyroid; Thyroid hormone