title: Natural Products Targeting EGFR Signaling Pathways as Potential Anticancer Drugs.
abstract: The epidermal growth factor receptor (EGFR) belongs to ErbB family of tyrosine kinases, which plays an important role in the regulation of cell proliferation, survival, differentiation, and metastasis. In addition, tumors develop resistance to EGFR inhibitors due to the presence or development of point mutations in the tyrosine kinase domain of the receptor. There is an urgent need to develop new anti-EGFR agents with strong therapeutic activities. As the majority of anticancer drugs are of natural origin, natural products are a valuable source for the identification and development of novel treatment options for cancer. To identify promising new anti-tumor agents that act on the EGFR, numerous studies have been carried out and some investigators found natural products that could effectively inhibit the EGFR. This review summarizes the latest developments related to anti- EGFR agents derived from natural compounds and traditional Chinese medicine (TCM).
authors.affiliation: School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.|Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, 201203, China.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Wang
authors.affiliation: School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.|Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, 201203, China.|Cell Biology Group of Shanghai Chempartner Ltd, Shanghai, 201203, China.
authors.forename: Linfeng
authors.initials: L
authors.lastname: Xu
authors.affiliation: School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.|Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, 201203, China.
authors.forename: Yuanzhi
authors.initials: Y
authors.lastname: Lao
authors.affiliation: School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.|Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, 201203, China.
authors.forename: Hongmei
authors.initials: H
authors.lastname: Zhang
authors.affiliation: School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.|Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, 201203, China.
authors.forename: Hongxi
authors.initials: H
authors.lastname: Xu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D001688:Biological Products / Q000737:chemistry* / Q000494:pharmacology; D049109:Cell Proliferation; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology; D066246:ErbB Receptors / Q000378:metabolism*; D006801:Humans; D058990:Molecular Targeted Therapy; D047428:Protein Kinase Inhibitors / Q000737:chemistry / Q000494:pharmacology; D015398:Signal Transduction
chemical_list: D000970:Antineoplastic Agents; D001688:Biological Products; D004365:Drugs, Chinese Herbal; D047428:Protein Kinase Inhibitors; D066246:ErbB Receptors
keywords: EGFR; cancer; natural compounds; therapeutic agents.; traditional chinese medicine; tyrosine kinase inhibitor