title: Neuropeptide cycloprolylglycine is an endogenous positive modulator of AMPA receptors.
abstract: We have previously shown that neuropeptide cycloprolylglycine (CPG) increases the content of brain-derived neurotrophic factor (BDNF) in the culture of neuronal cells under normal conditions and in pathology. This is the first study to show that CPG at a physiological concentration of 10-6M significantly enhances the transmembrane AMPA currents in rat cerebellar Purkinje cells. Thus, CPG is a positive endogenous modulator of AMPA receptors. It was assumed that the neuropsychotropic effects of CPG are implemented as a result of BDNF accumulation after the activation of AMPA receptors by this neuropeptide.
authors.affiliation: Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, ul. Baltiiskaya 8, Moscow, 125315, Russia. tata-sosnovka@mail.ru.
authors.forename: T A
authors.initials: TA
authors.lastname: Gudasheva
authors.affiliation: Institute of Physiologically Active Compounds, Russian Academy of Sciences, Severnyi proezd 1, Chernogolovka, Moscow oblast, 142432, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Grigoriev
authors.affiliation: Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, ul. Baltiiskaya 8, Moscow, 125315, Russia.
authors.forename: K N
authors.initials: KN
authors.lastname: Koliasnikova
authors.affiliation: Institute of Physiologically Active Compounds, Russian Academy of Sciences, Severnyi proezd 1, Chernogolovka, Moscow oblast, 142432, Russia.
authors.forename: V L
authors.initials: VL
authors.lastname: Zamoyski
authors.affiliation: Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, ul. Baltiiskaya 8, Moscow, 125315, Russia.
authors.forename: S B
authors.initials: SB
authors.lastname: Seredenin
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D018683:Excitatory Amino Acid Agents / Q000008:administration & dosage*; D007608:Kainic Acid / Q000008:administration & dosage; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D018408:Patch-Clamp Techniques; D010456:Peptides, Cyclic / Q000008:administration & dosage* / Q000378:metabolism*; D011619:Psychotropic Drugs / Q000008:administration & dosage; D011689:Purkinje Cells / Q000187:drug effects* / Q000502:physiology*; D017208:Rats, Wistar; D018091:Receptors, AMPA / Q000378:metabolism*
chemical_list: D018683:Excitatory Amino Acid Agents; D010456:Peptides, Cyclic; D011619:Psychotropic Drugs; D018091:Receptors, AMPA; C062238:cyclo(prolylglycyl); D007608:Kainic Acid