title: Effect of sılymarın on oxıdatıve stress and lıver hıstopathology ın experımental obstructıve jaundıce model.
abstract: To investigate the effect of silymarin on oxidative stress and hepatic injury induced by obstructive jaundice in an experimental model.
  Thirty Wistar-Albino type female rats were divided into 3 groups each including 10 rats. Only laparotomy was performed in group 1. Bile duct ligation was performed in group 2. In group 3, bile duct ligation was performed and orogastic silymarin 300 mg/kg/day dose was given for seven days. At the end of seven days, rats were sacrificed. The blood and liver tissue samples were taken to be examined biochemically and histopathologically.
  The plasma and liver levels of malondialdehyde were significantly lower in silymarin group than in the bile duct ligated group. Although liver levels of GSH were significantly higher in silymarin group than in the bile duct ligated group, there was no significant difference between the plasma GSH levels of these groups. In silymarin group; the enlargement of hepatocytes, dilatation of canaliculi and the edema were regressed.
  Silymarin diminished the harmful effects of obstructive jaundice on liver.
authors.affiliation: MD, General Surgeon, Ankara Education and Research Hospital, Department of General Surgery, Ankara, Turkey. Design of the study, acquisition of data, technical procedures.
authors.forename: Ali Kemal
authors.initials: AK
authors.lastname: Onalan
authors.affiliation: MD, General Surgeon, Ankara Education and Research Hospital, Department of General Surgery, Ankara, Turkey. Design of the study, analysis of data, technical procedures.
authors.forename: Salih
authors.initials: S
authors.lastname: Tuncal
authors.affiliation: MD, Histopathologist, Professor, Ufuk University, Faculty of Medicine, Department of Histology and Embriology, Ankara, Turkey. Histopathological examinations.
authors.forename: Sibel
authors.initials: S
authors.lastname: Kilicoglu
authors.affiliation: MD, General Surgeon, Ministry of Health, Turkish Medicines and Medical Devices Agency, Ankara, Turkey. Conception of the study, interpretation of data.
authors.forename: Salih
authors.initials: S
authors.lastname: Celepli
authors.affiliation: PhD, Biochemistrian, Ankara University, Faculty of Medicine, Department of Biochemistry, Ankara, Turkey. Biochemical analyses.
authors.forename: Esra
authors.initials: E
authors.lastname: Durak
authors.affiliation: Associate Professor, General Surgeon, Ankara Education and Research Hospital, Department of General Surgery, Ankara, Turkey. MManuscript preparation and writing, technical procedures.
authors.forename: Bulent
authors.initials: B
authors.lastname: Kilicoglu
authors.affiliation: MD, Biochemistrian, Professor, Ankara University, Faculty of Medicine, Department of Biochemistry, Ankara, Turkey. Biochemical analyses.
authors.forename: Erdinc
authors.initials: E
authors.lastname: Devrim
authors.affiliation: MD, General Surgeon, Ankara Education and Research Hospital, Department of General Surgery, Ankara, Turkey. Statistical analysis.
authors.forename: Aziz Mutlu
authors.initials: AM
authors.lastname: Barlas
authors.affiliation: Associate Professor, General Surgeon, Ankara Education and Research Hospital, Department of General Surgery, Ankara, Turkey. Critical revision, final approval.
authors.forename: Kemal
authors.initials: K
authors.lastname: Kismet
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001652:Bile Ducts; D005260:Female; D005978:Glutathione / Q000097:blood; D041781:Jaundice, Obstructive / Q000150:complications* / Q000473:pathology; D008026:Ligation; D008099:Liver / Q000473:pathology*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D018384:Oxidative Stress / Q000187:drug effects*; D020011:Protective Agents / Q000494:pharmacology; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012838:Silymarin / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D020011:Protective Agents; D012838:Silymarin; D008315:Malondialdehyde; D005978:Glutathione