title: Rapid Fatal Outcome of Cryptococcal Meningoencephalitis in a Non-HIV Immunocompromised Patient with a Low Fluconazole Susceptibility Isolate: A Case Report from Madagascar.
abstract: Cryptococcal meningoencephalitis is considered rare in HIV-negative individuals. In Madagascar, the epidemiology of cryptococcosis has not yet been well described, neither in immunocompetent nor in immunocompromised patients. We report here the first Malagasy detailed case of cryptococcal meningoencephalitis in a non-HIV immunocompromised adult patient carrying a low fluconazole susceptibility isolate. We emphasize the importance of early and accurate diagnosis to meet the challenges of managing cryptococcosis in developing countries.
authors.affiliation: Service des Maladies Infectieuses, HU Joseph Raseta de Befelatanana, Antananarivo, Madagascar.
authors.forename: Mihaja
authors.identifier: 0000-0001-8857-5834
authors.initials: M
authors.lastname: Raberahona
authors.affiliation: Service des Maladies Infectieuses, CHU Tambohobe, Fianarantsoa, Madagascar.
authors.forename: Rivonirina A
authors.initials: RA
authors.lastname: Rakotoarivelo
authors.affiliation: Centre d'Infectiologie Charles Mérieux, Antananarivo, Madagascar.
authors.forename: Njary
authors.initials: N
authors.lastname: Randriamampionona
authors.affiliation: Centre d'Infectiologie Charles Mérieux, Antananarivo, Madagascar.
authors.forename: Angelot F
authors.initials: AF
authors.lastname: Rakotomalala
authors.affiliation: Service des Maladies Infectieuses, HU Joseph Raseta de Befelatanana, Antananarivo, Madagascar.
authors.forename: Tiana
authors.initials: T
authors.lastname: Razafinambinintsoa
authors.affiliation: Service d'Hygiène, Epidémiologie et Prévention, Hospices Civils de Lyon, Lyon, France; Laboratoire des Pathogènes Emergents, Fondation Mérieux, Centre International de Recherche en Infectiologie (CIRI), INSERM U1111, CNRS UMR5308, ENS de Lyon, UCBL1, Lyon, France.
authors.forename: Thomas
authors.initials: T
authors.lastname: Bénet
authors.affiliation: Service d'Hygiène, Epidémiologie et Prévention, Hospices Civils de Lyon, Lyon, France; Laboratoire des Pathogènes Emergents, Fondation Mérieux, Centre International de Recherche en Infectiologie (CIRI), INSERM U1111, CNRS UMR5308, ENS de Lyon, UCBL1, Lyon, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Vanhems
authors.affiliation: Service des Maladies Infectieuses, HU Joseph Raseta de Befelatanana, Antananarivo, Madagascar.
authors.forename: Mamy J D D
authors.initials: MJ
authors.lastname: Randria
authors.affiliation: Laboratoire de Parasitologie-Mycologie, Institut de Biologie et de Pathologie, CHU Grenoble Alpes, Grenoble, France; Laboratoire TIMC-IMAG-TheREx, Université Grenoble-Alpes, Grenoble, France.
authors.forename: Muriel
authors.initials: M
authors.lastname: Cornet
authors.affiliation: Centre d'Infectiologie Charles Mérieux, Antananarivo, Madagascar.
authors.forename: Mala
authors.identifier: 0000-0001-6767-9554
authors.initials: M
authors.lastname: Rakoto-Andrianarivelo