title: Serum chemerin is associated with inflammatory and metabolic parameters-results of a population-based study.
abstract: This study aimed to confirm existing assumptions about the associations of circulating chemerin with inflammatory and metabolic parameters in a large population-based study.
  
  
  
  Data of 3,986 subjects from the Study of Health in Pomerania were analyzed. Residual method was used to investigate the different associations of visceral (VAT) and subcutaneous adipose tissue (SAT) with serum chemerin levels. Multivariable regression models were applied to examine the association of chemerin with high-sensitivity C-reactive protein, fibrinogen, glucose, glycated hemoglobin, lipid profile, blood pressure, diabetes, dyslipidemia, and hypertension.
  
  
  
  Positive associations with chemerin were observed for VAT and SAT with a stronger relation found for VAT. After adjustment for waist circumference, increased chemerin levels were related to higher inflammatory cytokines and glycated hemoglobin and an unfavorable lipid profile. Logistic regression revealed positive associations of chemerin with dyslipidemia [highest vs. lowest quartile: odds ratio (OR) 1.56 (95% confidence interval (CI) 1.25-1.94)] and hypertension [OR 1.31 (95% CI 1.03-1.68)].
  
  
  
  Chemerin levels are significantly linked to inflammation and metabolic syndrome. The majority of the detected associations persisted even after adjustment for waist circumference, suggesting that the relation of chemerin with the analyzed traits cannot be solely explained by an accumulation of adipose tissue.
authors.affiliation: Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Germany.|German Centre for Cardiovascular Research (DZHK), Greifswald, Germany.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Zylla
authors.affiliation: Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Germany.|German Centre for Cardiovascular Research (DZHK), Greifswald, Germany.
authors.forename: Maik
authors.initials: M
authors.lastname: Pietzner
authors.affiliation: Department of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Germany.
authors.forename: Jens-Peter
authors.initials: JP
authors.lastname: Kühn
authors.affiliation: German Centre for Cardiovascular Research (DZHK), Greifswald, Germany.|Institute for Community Medicine, University Medicine Greifswald, Germany.|German Center for Diabetes Research (DZD), Greifswald, Germany.
authors.forename: Henry
authors.initials: H
authors.lastname: Völzke
authors.affiliation: German Centre for Cardiovascular Research (DZHK), Greifswald, Germany.|Department of Internal Medicine B, University Medicine Greifswald, Germany.
authors.forename: Marcus
authors.initials: M
authors.lastname: Dörr
authors.affiliation: Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Germany.|German Centre for Cardiovascular Research (DZHK), Greifswald, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Nauck
authors.affiliation: Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Germany.|German Centre for Cardiovascular Research (DZHK), Greifswald, Germany.|Research Centre for Prevention and Health, Glostrup, Capital Region of Denmark, Denmark.
authors.forename: Nele
authors.initials: N
authors.lastname: Friedrich
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure; D002097:C-Reactive Protein / Q000378:metabolism; D018925:Chemokines / Q000097:blood*; D016207:Cytokines / Q000378:metabolism; D050171:Dyslipidemias / Q000097:blood / Q000378:metabolism*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000378:metabolism*; D007249:Inflammation / Q000378:metabolism; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D050152:Intra-Abdominal Fat / Q000378:metabolism*; D008055:Lipids / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000378:metabolism*; D008875:Middle Aged; D050151:Subcutaneous Fat / Q000378:metabolism*; D055105:Waist Circumference
chemical_list: D018925:Chemokines; D016207:Cytokines; D036341:Intercellular Signaling Peptides and Proteins; D008055:Lipids; C478630:RARRES2 protein, human; D002097:C-Reactive Protein