title: Qualitative and quantitative assessment of self-reported cognitive difficulties in nondemented elders: Association with medical help seeking, cognitive deficits, and β-amyloid imaging.
abstract: BACKGROUND
  Subjective cognitive decline (SCD) could help identify early stages of Alzheimer's disease. However, SCD is multidetermined and protean, and the type of cognitive complaint associated with preclinical Alzheimer's disease needs refinement.
  
  
  METHODS
  A total of 185 nondemented elders recruited from either the community or from a memory clinic filled a questionnaire. We searched for item responses associated with medical help seeking, cognitive deficits, and β-amyloidosis.
  
  
  RESULTS
  Compared with community-recruited control subjects (n= 74), help-seeking patients reported a stronger multidomain SCD that was mostly unrelated to the presence of detectable cognitive deficits. Only a few items, notably assessing temporal disorientation, distinguished help-seeking patients with (n= 78) or without (n= 33) memory deficits. Associations between SCD and β-amyloidosis were not restricted to the memory domain and varied across clinical stages.
  
  
  CONCLUSIONS
  Detailed evaluation of SCD could provide accessible indication of the presence of β-amyloid or cognitive deficits, which might prove useful for early diagnosis and clinical trial enrichment strategies.
authors.affiliation: INSERM, U1077, Caen, France; Université de Caen Normandie, UMR-S1077, Caen, France; Ecole Pratique des Hautes Etudes, UMR-S1077, Caen, France; CHU de Caen, U1077, Caen, France.
authors.forename: Renaud
authors.initials: R
authors.lastname: La Joie
authors.affiliation: INSERM, U1077, Caen, France; Université de Caen Normandie, UMR-S1077, Caen, France; Ecole Pratique des Hautes Etudes, UMR-S1077, Caen, France; CHU de Caen, U1077, Caen, France.
authors.forename: Audrey
authors.initials: A
authors.lastname: Perrotin
authors.affiliation: INSERM, U1077, Caen, France; Université de Caen Normandie, UMR-S1077, Caen, France; Ecole Pratique des Hautes Etudes, UMR-S1077, Caen, France; CHU de Caen, U1077, Caen, France.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Egret
authors.affiliation: Department of Neurology, Memory Research and Resources Clinic, University Hospital of Lille, Lille, France; Université de Lille Nord de France, Lille, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Pasquier
authors.affiliation: INSERM, U1077, Caen, France; Université de Caen Normandie, UMR-S1077, Caen, France; Ecole Pratique des Hautes Etudes, UMR-S1077, Caen, France; CHU de Caen, U1077, Caen, France.
authors.forename: Clémence
authors.initials: C
authors.lastname: Tomadesso
authors.affiliation: INSERM, U1077, Caen, France; Université de Caen Normandie, UMR-S1077, Caen, France; Ecole Pratique des Hautes Etudes, UMR-S1077, Caen, France; CHU de Caen, U1077, Caen, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Mézenge
authors.affiliation: INSERM, U1077, Caen, France; Université de Caen Normandie, UMR-S1077, Caen, France; Ecole Pratique des Hautes Etudes, UMR-S1077, Caen, France; CHU de Caen, U1077, Caen, France.
authors.forename: Béatrice
authors.initials: B
authors.lastname: Desgranges
authors.affiliation: INSERM, U1077, Caen, France; Université de Caen Normandie, UMR-S1077, Caen, France; Ecole Pratique des Hautes Etudes, UMR-S1077, Caen, France; CHU de Caen, Service de Neurologie, Caen, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: de La Sayette
authors.affiliation: INSERM, U1077, Caen, France; Université de Caen Normandie, UMR-S1077, Caen, France; Ecole Pratique des Hautes Etudes, UMR-S1077, Caen, France; CHU de Caen, U1077, Caen, France.
authors.forename: Gaël
authors.initials: G
authors.lastname: Chételat
keywords: Anosognosia; Biomarkers; Memory complaint; Mild cognitive impairment; Orientation; Positron emission tomography; Preclinical; Prodromal Alzheimer's disease; Subjective cognitive decline; β-Amyloid