title: Good outcome of living donor liver transplantation in drug-induced acute liver failure: A single-center experience.
abstract: Drug-induced acute liver failure (ALF) is associated with high mortality. There is limited literature on results of living donor liver transplantation (LDLT).
  
  
  
  The study was conducted at a tertiary care center in North India. All patients who received LDLT for drug-induced ALF were included. The data are shown as median (IQR).
  
  
  
  A total of 18 patients (15 females and three males), aged 34 (25-45) years, underwent LDLT for drug-induced liver injury (DILI)-related ALF. Etiology of ALF was antitubercular medications (n=14), orlistat (n=1), flutamide (n=1), and complementary alternative medications (n=2). The baseline parameters were as following: bilirubin 17.7 (16.3-23.8) mg/dL, INR 3.3 (2.5-4.0), jaundice encephalopathy interval 6 (3-17.5) days, arterial ammonia 109 μmol/L (73-215), Model for End-Stage Liver Disease (MELD) 24 (18-33), grade of encephalopathy 2 (1-4), which progressed to grade 3 (3-4) before transplantation. All patients underwent right lobe LDLT; hospital stay was 17 (13-22) days, and ICU stay was 5 (5-7) days. Two patients died in the first month after liver transplantation due to sepsis and multi-organ failure; the rest of the patients are alive and doing well at a follow-up of 50 (4-82 months).
  
  
  
  Good outcomes can be obtained by LDLT for drug-induced ALF.
authors.affiliation: Institute of Liver Transplantation and Regenerative Medicine, Medanta, The Medicity, Gurgaon, India.
authors.forename: Narendra Singh
authors.identifier: 0000-0002-4387-0036
authors.initials: NS
authors.lastname: Choudhary
authors.affiliation: Institute of Liver Transplantation and Regenerative Medicine, Medanta, The Medicity, Gurgaon, India.
authors.forename: Sanjiv
authors.initials: S
authors.lastname: Saigal
authors.affiliation: Institute of Liver Transplantation and Regenerative Medicine, Medanta, The Medicity, Gurgaon, India.
authors.forename: Neeraj
authors.initials: N
authors.lastname: Saraf
authors.affiliation: Institute of Liver Transplantation and Regenerative Medicine, Medanta, The Medicity, Gurgaon, India.
authors.forename: Amit
authors.initials: A
authors.lastname: Rastogi
authors.affiliation: Institute of Liver Transplantation and Regenerative Medicine, Medanta, The Medicity, Gurgaon, India.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Goja
authors.affiliation: Institute of Liver Transplantation and Regenerative Medicine, Medanta, The Medicity, Gurgaon, India.
authors.forename: Prashant
authors.initials: P
authors.lastname: Bhangui
authors.affiliation: Institute of Liver Transplant Anesthesia, Medanta, The Medicity, Gurgaon, India.
authors.forename: Vijay
authors.initials: V
authors.lastname: Vohra
authors.affiliation: Institute of Critical Care, Medanta, The Medicity, Gurgaon, India.
authors.forename: Deepak
authors.initials: D
authors.lastname: Govil
authors.affiliation: Institute of Liver Transplantation and Regenerative Medicine, Medanta, The Medicity, Gurgaon, India.
authors.forename: Arvinder S
authors.initials: AS
authors.lastname: Soin
mesh_terms: D000328:Adult; D056486:Chemical and Drug Induced Liver Injury / Q000401:mortality* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016031:Liver Transplantation / Q000401:mortality*; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D015996:Survival Rate; D062606:Tertiary Care Centers; D013997:Time Factors; D016896:Treatment Outcome
keywords: acute liver failure; antitubercular treatment; drug-induced liver injury; living donor liver transplantation; survival