title: Personality Traits and Health-Related Quality of Life Among Adolescent and Young Adult Cancer Patients: The Role of Psychological Distress.
abstract: Personality may affect the way adolescents and young adults (AYAs) with cancer report health-related quality of life (HRQoL). Patients aged 15-39 years (n = 165) completed a survey at 12-16 months postdiagnosis. The survey included questions on HRQoL (SF-36), distress Brief Symptom Inventory-18, and personality (NEO-Five-Factor Inventory). Personality traits were not associated with physical HRQoL. The personality trait neuroticism was negatively associated with mental HRQoL (β = -0.37; p < 0.001) and positively with psychological distress (β = 0.47; p < 0.001). Hierarchical regression and mediation analyses indicated that psychological distress fully mediated the association between neuroticism and mental HRQoL. Findings emphasize the importance of psychosocial intervention for distress in AYAs with cancer.
authors.affiliation: 1 Department of Medical Psychology, Radboud University Medical Center , Nijmegen, The Netherlands .
authors.forename: Olga
authors.initials: O
authors.lastname: Husson
authors.affiliation: 2 University of Michigan School of Social Work , Ann Arbor, Michigan.
authors.forename: Bradley
authors.initials: B
authors.lastname: Zebrack
authors.affiliation: 3 MNR Analytics , Portland, Oregon.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Block
authors.affiliation: 4 Department of Pediatric Hematology/Oncology, University of Texas Health Science Center at San Antonio , San Antonio, Texas.
authors.forename: Leanne
authors.initials: L
authors.lastname: Embry
authors.affiliation: 4 Department of Pediatric Hematology/Oncology, University of Texas Health Science Center at San Antonio , San Antonio, Texas.
authors.forename: Christine
authors.initials: C
authors.lastname: Aguilar
authors.affiliation: 5 Oregon Health and Sciences University , Portland, Oregon.
authors.forename: Brandon
authors.initials: B
authors.lastname: Hayes-Lattin
authors.affiliation: 6 HopeLab Foundation , Redwood City, California.
authors.forename: Steve
authors.initials: S
authors.lastname: Cole
mesh_terms: D000293:Adolescent; D000328:Adult; D001007:Anxiety / Q000523:psychology*; D005260:Female; D006304:Health Status; D006801:Humans; D016014:Linear Models; D008297:Male; D009369:Neoplasms / Q000523:psychology* / Q000628:therapy; D010551:Personality; D011788:Quality of Life / Q000523:psychology*; D013315:Stress, Psychological / Q000523:psychology*; D055815:Young Adult
keywords: health-related quality of life; neuroticism; personality; psychological distress; survivorship