title: Cyclocurcumin, an Antivasoconstrictive Constituent of Curcuma longa (Turmeric).
abstract: Despite the increasing attention on the therapeutic potential of Curcuma longa (turmeric), the biological activities of curcuminoids other than curcumin are not well understood. Here, we investigated antivasoconstrictive activities of C. longa extract and its ingredients using freshly isolated rat aortic rings. C. longa extract significantly suppressed agonist-stimulated vasoconstriction, and cyclocurcumin was found to be the most potent (IC50against phenylephrine-induced vasoconstriction: 14.9 ± 1.0 μM) among the 10 tested ingredients including four curcuminoids. Cyclocurcumin significantly inhibited contraction of vascular smooth muscle, which was mediated by the suppression of myosin-light-chain phosphorylation and calcium influx via the L-type calcium channel. The inhibitory effect of cyclocurcumin was observed to be reversible and without cytotoxicity. Taken together, we demonstrated that cyclocurcumin, a bioactive ingredient in C. longa, may have a therapeutic potential as a novel antivasoconstrictive natural product.
authors.affiliation: College of Pharmacy, Seoul National University , Seoul 08826, Korea.
authors.forename: Keunyoung
authors.initials: K
authors.lastname: Kim
authors.affiliation: College of Pharmacy, Seoul National University , Seoul 08826, Korea.
authors.forename: Jung-Jun
authors.initials: JJ
authors.lastname: Kim
authors.affiliation: College of Pharmacy, Seoul National University , Seoul 08826, Korea.
authors.forename: Yeryeon
authors.initials: Y
authors.lastname: Jung
authors.affiliation: College of Pharmacy, Seoul National University , Seoul 08826, Korea.
authors.forename: Ji-Yoon
authors.initials: JY
authors.lastname: Noh
authors.affiliation: College of Pharmacy, Hanyang University , Ansan 15588, Korea.
authors.forename: Ahmed Shah
authors.initials: AS
authors.lastname: Syed
authors.affiliation: College of Pharmacy, Hanyang University , Ansan 15588, Korea.
authors.forename: Chul Young
authors.initials: CY
authors.lastname: Kim
authors.affiliation: College of Pharmacy, Dongguk University , Goyang 10326, Korea.
authors.forename: Moo-Yeol
authors.initials: MY
authors.lastname: Lee
authors.affiliation: College of Pharmacy, Ewha Womans University , Seoul 03760, Korea.
authors.forename: Kyung-Min
authors.initials: KM
authors.lastname: Lim
authors.affiliation: College of Pharmacy, Hanyang University , Ansan 15588, Korea.
authors.forename: Ok-Nam
authors.initials: ON
authors.lastname: Bae
authors.affiliation: College of Pharmacy, Seoul National University , Seoul 08826, Korea.
authors.forename: Jin-Ho
authors.identifier: 0000-0002-7248-2980
authors.initials: JH
authors.lastname: Chung
mesh_terms: D000818:Animals; D020746:Calcium Channels, L-Type / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D030024:Curcuma / Q000737:chemistry*; D003474:Curcumin / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010766:Phosphorylation; D051381:Rats; D014661:Vasoconstriction / Q000187:drug effects*
chemical_list: D020746:Calcium Channels, L-Type; D003474:Curcumin