title: Large Cell Calcifying Sertoli Cell Tumour of Testis-A Rare Case Report.
abstract: Sertoli cell tumours of testes are classified into sertoli cell tumour NOS (not otherwise specified), sclerosing variant and large cell calcifying variant. So far, 90 cases of the large cell calcifying variant have been reported in literature. We describe a rare case of inhibin negative locally invasive large cell calcifying sertoli cell tumour of testis. A 62-year-old man presented with complaints of pain and swelling in right scrotum for 8 months. Ultrasound revealed a right testicular mass with internal vascularity and calcification. Gross examination of right inguinal orchiectomy specimen showed firm to hard mass with yellow areas and calcification seen on cut section. Microscopy revealed a tumour in the testis infiltrating the epididymis and rete testis and reaching up to the skin. Tumour cells were arranged in the form of solid nests, tubules and cords with neutrophilic stromal infiltrate and calcification. Tumour cells had abundant clear to eosinophilic cytoplasm, round nucleus with vesicular chromatin and conspicuous nucleoli. On immunohistochemistry, tumour cells were positive for pan cytokeratin, Epithelial Membrane Antigen (EMA), S-100 protein, desmin, vimentin, neuron specific enolase, and chromogranin. However, it was negative for inhibin alpha, OCT4, CD10, CD99, Melan A. Inhibin negative large cell calcifying sertoli cell tumour is a rare entity.
authors.affiliation: Postgraduate Student, Department of Pathology, University College of Medical Sciences , Dilshad Garden, Delhi, India .
authors.forename: Harresh
authors.initials: H
authors.lastname: Kumar
authors.affiliation: Associate Professor, Department of Pathology, University College of Medical Sciences , Dilshad Garden, Delhi, India .
authors.forename: Nadeem
authors.initials: N
authors.lastname: Tanveer
authors.affiliation: Assistant Professor, Department of Radiology, University College of Medical Sciences , Dilshad Garden, Delhi, India .
authors.forename: Natasha
authors.initials: N
authors.lastname: Gupta
authors.affiliation: Director and Professor, Department of Pathology, University College of Medical Sciences , Dilshad Garden, Delhi, India .
authors.forename: Kiran
authors.initials: K
authors.lastname: Mishra
keywords: Calcification; Inhibin; Orchiectomy