title: Iridium-Catalyzed Intramolecular Asymmetric Allylic Dearomatization Reaction of Benzoxazoles, Benzothiazoles, and Benzimidazoles.
abstract: An iridium-catalyzed intramolecular asymmetric allylic dearomatization reaction of benzoxazoles, benzothiazoles, and benzimidazoles was developed. The reaction was found to be compatible with a wide range of five-membered-ring electron-deficient heteroaromatic compounds and furnished the corresponding dearomatized heterocycles in high yield with excellent enantioselectivity.
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai, 200032, China.
authors.forename: Ze-Peng
authors.initials: ZP
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai, 200032, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Zheng
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai, 200032, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Huang
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai, 200032, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Qian
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai, 200032, China.
authors.forename: Shu-Li
authors.initials: SL
authors.lastname: You
mesh_terms: D000498:Allyl Compounds / Q000737:chemistry*; D001562:Benzimidazoles / Q000737:chemistry*; D052160:Benzothiazoles / Q000737:chemistry*; D001583:Benzoxazoles / Q000737:chemistry*; D002384:Catalysis; D055808:Drug Discovery; D007495:Iridium / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000498:Allyl Compounds; D001562:Benzimidazoles; D052160:Benzothiazoles; D001583:Benzoxazoles; D007495:Iridium
keywords: asymmetric catalysis; dearomatization; drug discovery; heterocycles; iridium