title: Systems Pharmacology Based Study of the Molecular Mechanism of SiNiSan Formula for Application in Nervous and Mental Diseases.
abstract: Background.Mental disorder is a group of systemic diseases characterized by a variety of physical and mental discomfort, which has become the rising threat to human life. Herbal medicines were used to treat mental disorders for thousand years in China in which the molecular mechanism is not yet clear.Objective.To systematically explain the mechanisms of SiNiSan (SNS) formula on the treatment of mental disorders.Method.A systems pharmacology method, with ADME screening, targets prediction, and DAVID enrichment analysis, was employed as the principal approach in our study.Results.60 active ingredients of SNS formula and 187 mental disorders related targets were discovered to have interactions with them. Furthermore, the enrichment analysis of drug-target network showed that SNS probably acts through "multi-ingredient, multitarget, and multisystems" holistic coordination in different organs pattern by indirectly regulating the nutritional and metabolic pathway even their serial complications.Conclusions.Our research provides a reference for the molecular mechanism of medicinal herbs in the treatment of mental disease on a systematic level. Hopefully, it will also provide a theoretical basis for the discovery of lead compounds of natural medicines for other diseases based on traditional medicine.
authors.affiliation: College of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an, Shaanxi 712046, China.
authors.forename: Xia
authors.identifier: 0000-0002-3031-5148
authors.initials: X
authors.lastname: Shen
authors.affiliation: College of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an, Shaanxi 712046, China.
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Zhao
authors.affiliation: College of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an, Shaanxi 712046, China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Luo
authors.affiliation: College of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an, Shaanxi 712046, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.affiliation: College of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an, Shaanxi 712046, China.
authors.forename: Benxiang
authors.initials: B
authors.lastname: Hu
authors.affiliation: Bioinformatics Center, College of Life Science, Northwest A&F University, Yangling, Shaanxi 712100, China.
authors.forename: Zihu
authors.initials: Z
authors.lastname: Guo