title: Calculated panel reactive antibody with decimals: A refined metric of access to transplantation for highly sensitized candidates.
abstract: The use of the calculated panel reactive antibody (CPRA) value and the implementation of allocation points for sensitized candidates by the United Network for Organ Sharing (UNOS) have improved access to kidney transplantation for highly sensitized candidates (98% CPRA and above). Despite this, a large population of highly sensitized candidates remain awaiting transplantation. To better define this population, we propose the use of two refinements of the standard UNOS CPRA, the CPRA with decimals or CPRAd, and the likelihood of a compatible donor (LCD). These refined metrics of the standard UNOS CPRA will allow transplant programs to describe their patients' access to transplantation with increased granularity and will help in decisions regarding the use of desensitization.
authors.affiliation: Cedars-Sinai Heart Institute, Beverly Hills, CA, USA.
authors.forename: Evan P
authors.initials: EP
authors.lastname: Kransdorf
authors.affiliation: Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, Phoenix, AZ, USA. Electronic address: pandorigal.marcelo@mayo.edu.
authors.forename: Marcelo J
authors.initials: MJ
authors.lastname: Pando
mesh_terms: D006680:HLA Antigens / Q000235:genetics / Q000276:immunology; D006650:Histocompatibility Testing / Q000379:methods*; D006801:Humans; D007518:Isoantibodies / Q000276:immunology; D016030:Kidney Transplantation; D015203:Reproducibility of Results; D014019:Tissue Donors / Q000706:statistics & numerical data*; D009927:Tissue and Organ Procurement / Q000379:methods* / Q000706:statistics & numerical data*; D014850:Waiting Lists
chemical_list: D006680:HLA Antigens; D007518:Isoantibodies
keywords: Calculated panel reactive antibody; Histocompatibility; Sensitization; Transplantation