title: Anti-plaque and antimicrobial efficiency of different oral rinses in a 3-day plaque accumulation model.
abstract: The idea of incorporating a mouthrinse with normal tooth brushing could be a useful adjunct to oral hygiene. Despite the principle nature of the toothpaste vehicle, most alcohol-based chemical plaque-control agents have been evaluated and later formulated in the mouthrinse vehicle. The current study was aimed to investigate the persistence of antimicrobial action and plaque inhibitory properties of a new alcohol-free mouthrinse when compared with positive control, chlorhexidine 0.12% and placebo control, physiologic saline solution mouthrinses. The evaluation of the antimicrobial activity was performed by saliva samples collected during the 3 days of usage. The results of this study indicate that this new oral rinse has an equivalent plaque inhibitory action to chlorhexidine, and the plaque inhibitory action of the rinse appears to be derived from a persistence of antimicrobial action in the mouth. Furthermore, no side effects were reported during the study, and the additional benefit of no alcohol presence in the rinse solution.
authors.affiliation: Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari Aldo Moro, Bari, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Cantore
authors.affiliation: Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari Aldo Moro, Bari, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Ballini
authors.affiliation: Department of Clinical and Experimental Medicine, Medical School, University of Foggia, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Mori
authors.affiliation: Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari Aldo Moro, Bari, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Dibello
authors.affiliation: Calabrodental SRL, Experimental Medicine Section, Crotone, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Marrelli
authors.affiliation: Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari Aldo Moro, Bari, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Mirgaldi
authors.affiliation: Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari Aldo Moro, Bari, Italy.
authors.forename: D
authors.initials: D
authors.lastname: De Vito
authors.affiliation: Tecnologica Research Institute, Biomedical Section, St. E. Fermi, Crotone, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Tatullo
mesh_terms: D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D019343:Citric Acid / Q000008:administration & dosage; D003773:Dental Plaque / Q000517:prevention & control*; D011756:Diphosphates / Q000008:administration & dosage; D006801:Humans; D008826:Microbial Sensitivity Tests; D009067:Mouthwashes / Q000737:chemistry / Q000627:therapeutic use*; D009910:Oral Hygiene / Q000379:methods*; D011122:Polyphosphates / Q000008:administration & dosage; D017680:Potassium Compounds / Q000008:administration & dosage; D012463:Saliva / Q000187:drug effects / Q000382:microbiology*; D017693:Sodium Bicarbonate / Q000008:administration & dosage; D012969:Sodium Fluoride / Q000008:administration & dosage
chemical_list: D000891:Anti-Infective Agents, Local; D011756:Diphosphates; D009067:Mouthwashes; D011122:Polyphosphates; D017680:Potassium Compounds; D019343:Citric Acid; D017693:Sodium Bicarbonate; D012969:Sodium Fluoride; C035389:tetrapotassium pyrophosphate; C005692:triphosphoric acid