title: Efficacy and safety of Chinese patent medicines in the treatment of recurrent aphthous stomatitis: A systematic review.
abstract: Recurrent aphthous stomatitis (RAS) is the most common chronic oral mucosal condition of the oral cavity. Investigators in clinical trials have evaluated the effectiveness of Chinese patent medicines in the treatment of RAS. However, the results are conflicting rather than conclusive. To evaluate the efficacy and safety of Chinese patent medicines for the treatment of RAS, the authors conducted a systematic review.
  
  
  
  The authors searched 9 electronic databases to identify randomized controlled trials (RCTs) or potential clinical controlled trials (CCTs), published in any language, in which the investigators compared Chinese patent medicines with vitamin tablets or placebos for the treatment of RAS.
  
  
  
  The authors included 11 RCTs and 1 CCT in the review. Results showed that Chinese patent medicines were beneficial for patients with RAS in relieving ulcer pain and reducing the duration and frequency of attacks. The reported adverse effects of Chinese patent medicines included stomachache, abdominal distention, diarrhea, mild nausea, and gastrointestinal discomfort, which were either self-limiting or could be relieved by treatment cessation.
  
  
  
  Chinese patent medicines may be effective for treatment of RAS by means of relieving pain and reducing ulcer size and episode duration and frequency.
authors.forename: Peiru
authors.initials: P
authors.lastname: Zhou
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Mao
authors.forename: Hong
authors.initials: H
authors.lastname: Hua
authors.forename: Xiaosong
authors.initials: X
authors.lastname: Liu
authors.forename: Zhimin
authors.initials: Z
authors.lastname: Yan
mesh_terms: D004365:Drugs, Chinese Herbal / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D012008:Recurrence; D013281:Stomatitis, Aphthous / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D004365:Drugs, Chinese Herbal
keywords: Chinese patent medicine; Recurrent aphthous stomatitis; efficacy; safety; systematic review