title: Assessment of Nasal Carriage of Staphylococcus Aureus and Axillar Flora in Patients With Acromegaly.
abstract: OBJECTIVE
  Recent study showed that patients with acromegaly have typical skin findings including increased sebum secretion, decreased transepidermal water loss, more alkaline, and colder skin surface correlated with serum growth hormone and insulin-like growth factor 1 levels. Different anatomic localizations and texture of the skin differ in bacterial concentrations.Nasal carriage of Staphylococcus aureus and axillar flora in patients with acromegaly was compared with normal population with regard to duration of acromegaly as well as the growth hormone and insulin-like growth factor 1 levels.
  
  
  METHODS
  This patient-control prospective study was conducted in university hospitals in Mersin, Turkey. The study consisted of 30 active acromegalic patients and 60 healthy adults who had no previously diagnosed chronic illness as a control group. A total of 90 volunteers were enrolled in this study; nasal and axillar cultures were obtained. Axillar and nasal specimens from anterior nares of the individuals were taken using sterile swabs.
  
  
  RESULTS
  Nasal colonization of Staphylococcus aureus was 13.3% in acromegalic patients, but 43.4% in control group. This difference was statistically significant (P = 0.004). Patients and control group compared according to axillar cultures, the authors determined proteus colonization 16.7% in patients with acromegaly but no proteus colonization in control group. This result was statistically significant (P = 0.001). Proteus colonization was negatively correlated only with disease duration in acromegalic patients (P = 0.017).
  
  
  CONCLUSIONS
  The authors demonstrated that compared with healthy subjects, acromegalic patients had low percentage of nasal carriage of Staphylococcus aureus and more gram-negative basili in the axillar flora. These nasal and axillar flora changes should be considered for prophylactic antibiotics use before surgery and ampiric antibiotics use after surgery.
authors.affiliation: *Department of Endocrinology and Metabolism†Department of Infection Disaese, School of Medicine, Mersin University, Yenişehir, Mersin, Turkey.
authors.forename: Ramazan
authors.initials: R
authors.lastname: Gen
authors.forename: Elif Şahin
authors.initials: EŞ
authors.lastname: Horasan
authors.forename: Ümit
authors.initials: Ü
authors.lastname: Çinkir
authors.forename: Kerem
authors.initials: K
authors.lastname: Sezer
authors.forename: Esen
authors.initials: E
authors.lastname: Akbay
mesh_terms: D000172:Acromegaly / Q000097:blood / Q000453:epidemiology / Q000382:microbiology; D000328:Adult; D001365:Axilla / Q000382:microbiology*; D002353:Carrier State / Q000175:diagnosis / Q000453:epidemiology / Q000382:microbiology; D016022:Case-Control Studies; D005260:Female; D006090:Gram-Negative Bacteria / Q000302:isolation & purification*; D013006:Growth Hormone / Q000032:analysis*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009296:Nasal Cavity / Q000382:microbiology*; D011446:Prospective Studies; D013211:Staphylococcus aureus / Q000302:isolation & purification*; D014421:Turkey / Q000453:epidemiology
chemical_list: D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone