title: Influence of EGFR mutational status on metastatic behavior in non squamous non small cell lung cancer.
abstract: Epidermal Growth Factor Receptor (EGFR) mutated Non Small Cell Lung Cancers (NSCLCs) are a molecularly subgroup of patients with peculiar clinic-pathological characteristics. Previous studies have suggested a possible interaction between oncogene status and metastatic behavior in non squamous NSCLCs with conflicting results. The aim of this study was to compare the different metastatic patterns, at baseline and during the course of the disease, in a cohort of 137 Caucasian patients with non-squamous NSCLC according to the EGFR mutational status and survival differences according to the different metastatic behavior. We observed unique metastatic distributions between EGFR-mutated and EGFR wild type non-squamous NSCLCs. These data support the hypothesis that tumor bio-molecular characteristics and genotype may influence the metastatic process in NSCLC and might help the development of enrichment strategies for tumor genotyping in these tumors, especially in the presence of limited tissue availability.
authors.affiliation: Medical Oncology Unit A.O. Papardo & Department of Human Pathology University of Messina, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Russo
authors.affiliation: Medical Oncology Unit A.O. Papardo & Department of Human Pathology University of Messina, Italy.
authors.forename: Tindara
authors.initials: T
authors.lastname: Franchina
authors.affiliation: Medical Oncology Unit A.O. Papardo & Department of Human Pathology University of Messina, Italy.
authors.forename: Giuseppina Rosaria Rita
authors.initials: GR
authors.lastname: Ricciardi
authors.affiliation: Fondazione Mario Negri Sud, Santa Maria Imbaro, Chieti, Italy.
authors.forename: Caterina
authors.initials: C
authors.lastname: Fanizza
authors.affiliation: Medical Oncology Unit A.O. Papardo & Department of Human Pathology University of Messina, Italy.
authors.forename: Antonino
authors.initials: A
authors.lastname: Scimone
authors.affiliation: Medical Oncology Unit A.O. Papardo & Department of Human Pathology University of Messina, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Chiofalo
authors.affiliation: Department of Medicine, Surgery and Neuroscience, University of Siena and Istituto Toscano Tumori (ITT), Siena, Italy.|Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia PA, USA.
authors.forename: Antonio
authors.initials: A
authors.lastname: Giordano
authors.affiliation: Medical Oncology Unit A.O. Papardo & Department of Human Pathology University of Messina, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Adamo
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000235:genetics*; D002289:Carcinoma, Non-Small-Cell Lung / Q000208:ethnology / Q000235:genetics* / Q000401:mortality / Q000556:secondary; D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000208:ethnology / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009154:Mutation; D010641:Phenotype; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D044465:White People / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; C512478:EGFR protein, human; D066246:ErbB Receptors
keywords: EGFR WT; EGFR mutations; NSCLC; brain metastases; metastatic spread