title: Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients.
abstract: Approximately 30% of epilepsy patients are refractory to antiepileptic drugs. In these cases, surgery is the only alternative to eliminate/control seizures. However, a significant minority of patients continues to exhibit post-operative seizures, even in those cases in which the suspected source of seizures has been correctly localized and resected. The protocol presented here combines a clinical procedure routinely employed during the pre-operative evaluation of temporal lobe epilepsy (TLE) patients with a novel technique for network analysis. The method allows for the evaluation of the temporal evolution of mesial network parameters. The bilateral insertion of foramen ovale electrodes (FOE) into the ambient cistern simultaneously records electrocortical activity at several mesial areas in the temporal lobe. Furthermore, network methodology applied to the recorded time series tracks the temporal evolution of the mesial networks both interictally and during the seizures. In this way, the presented protocol offers a unique way to visualize and quantify measures that considers the relationships between several mesial areas instead of a single area.
authors.affiliation: Neurosurgery & National Reference Unit for the Treatment of Refractory Epilepsy, Instituto de Investigación Sanitaria Hospital de la Princesa; ancor.sanz@gmail.com.
authors.forename: Ancor
authors.initials: A
authors.lastname: Sanz-García
authors.affiliation: Clinical Neurophysiology & National Reference Unit for the Treatment of Refractory Epilepsy, Instituto de Investigación Sanitaria Hospital de la Princesa.
authors.forename: Lorena
authors.initials: L
authors.lastname: Vega-Zelaya
authors.affiliation: Clinical Neurophysiology & National Reference Unit for the Treatment of Refractory Epilepsy, Instituto de Investigación Sanitaria Hospital de la Princesa.
authors.forename: Jesús
authors.initials: J
authors.lastname: Pastor
authors.affiliation: Neurosurgery & National Reference Unit for the Treatment of Refractory Epilepsy, Instituto de Investigación Sanitaria Hospital de la Princesa.
authors.forename: Cristina V
authors.initials: CV
authors.lastname: Torres
authors.affiliation: Neurosurgery & National Reference Unit for the Treatment of Refractory Epilepsy, Instituto de Investigación Sanitaria Hospital de la Princesa.
authors.forename: Rafael G
authors.initials: RG
authors.lastname: Sola
authors.affiliation: Neurosurgery & National Reference Unit for the Treatment of Refractory Epilepsy, Instituto de Investigación Sanitaria Hospital de la Princesa; CONICET.
authors.forename: Guillermo J
authors.initials: GJ
authors.lastname: Ortega
mesh_terms: D001931:Brain Mapping / Q000379:methods*; D004566:Electrodes; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000188:drug therapy* / Q000503:physiopathology* / Q000601:surgery; D054085:Foramen Ovale / Q000294:innervation*; D006801:Humans; D013702:Temporal Lobe