title: Intravitreal Versus Subretinal Tissue Plasminogen Activator Injection for Submacular Hemorrhage.
abstract: The objective of this study was to compare visual acuity outcomes between the following procedures used to treat submacular hemorrhages: pneumatic displacement followed by intravitreal tissue plasminogen activator (tPA) if needed (pneumatic ± tPA) and pars plana vitrectomy (PPV) with subretinal tPA (PPV + tPA).
  
  
  
  This is a retrospective chart review of submacular hemorrhages treated with either pneumatic ± tPA or PPV + tPA.
  
  
  
  Eighteen patients had pneumatic ± tPA, and 14 patients had PPV + tPA. The percentage of patients achieving three lines or greater of vision improvement 1 year postoperatively was 46% and 18% in these groups, respectively (P = .194).
  
  
  
  The difference in visual acuity was not statistically significant; however, the lack of a statistical difference is important as pneumatic ± tPA is a less-invasive, less costly procedure that can be done in a clinical setting. [Ophthalmic Surg Lasers Imaging Retina. 2017;48:26-32.].
authors.forename: James E
authors.initials: JE
authors.lastname: Bell
authors.forename: Julia P
authors.initials: JP
authors.lastname: Shulman
authors.forename: Russell J
authors.initials: RJ
authors.lastname: Swan
authors.forename: Michael P
authors.initials: MP
authors.lastname: Teske
authors.forename: Paul S
authors.initials: PS
authors.lastname: Bernstein
mesh_terms: D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007267:Injections; D058449:Intravitreal Injections; D008266:Macula Lutea / Q000473:pathology; D008297:Male; D012160:Retina; D012166:Retinal Hemorrhage / Q000175:diagnosis / Q000188:drug therapy*; D012189:Retrospective Studies; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage*; D041623:Tomography, Optical Coherence; D016896:Treatment Outcome; D014792:Visual Acuity
chemical_list: D010959:Tissue Plasminogen Activator