title: The role of tumor microenvironment in collective tumor cell invasion.
abstract: For many cancer types, cancer cells invade into surrounding tissues by collective movement of cell groups that remain connected via cell-cell junctions. This migration is completely distinguished from single-cell migration, in which cancer cells disrupt the tight intercellular junctions and gain a mesenchymal phenotype. Recently, emerging evidence has revealed that collective cell invasion depends on not only cell-intrinsic mechanisms but also on extracellular mechanisms by bidirectional interplay between the tumor cell and the tumor environment. Herein, in this review we discuss the role and underline mechanisms of tumor microenvironment in collective tumor cell invasion, particularly focusing on extracellular matrix remodeling and cross-talk between tumor and stromal cells.
authors.affiliation: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology (Sichuan University), No. 14, Sec. 3, Renminnan Road, Chengdu Sichuan 610041, PR China.|Department of Oral Pathology, West China Hospital of Stomatology (Sichuan University), No. 14, Sec. 3, Renminnan Road, Chengdu Sichuan 610041, PR China.
authors.forename: Jia-Shun
authors.initials: JS
authors.lastname: Wu
authors.affiliation: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology (Sichuan University), No. 14, Sec. 3, Renminnan Road, Chengdu Sichuan 610041, PR China.|Department of Oral & Maxillofacial Surgery, West China Hospital of Stomatology (Sichuan University), No. 14, Sec. 3, Renminnan Road, Chengdu Sichuan 610041, PR China.
authors.forename: Su-Rui
authors.initials: SR
authors.lastname: Sheng
authors.affiliation: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology (Sichuan University), No. 14, Sec. 3, Renminnan Road, Chengdu Sichuan 610041, PR China.|Department of Oral & Maxillofacial Surgery, West China Hospital of Stomatology (Sichuan University), No. 14, Sec. 3, Renminnan Road, Chengdu Sichuan 610041, PR China.
authors.forename: Xin-Hua
authors.initials: XH
authors.lastname: Liang
authors.affiliation: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology (Sichuan University), No. 14, Sec. 3, Renminnan Road, Chengdu Sichuan 610041, PR China.|Department of Oral Pathology, West China Hospital of Stomatology (Sichuan University), No. 14, Sec. 3, Renminnan Road, Chengdu Sichuan 610041, PR China.
authors.forename: Ya-Ling
authors.initials: YL
authors.lastname: Tang
mesh_terms: D000818:Animals; D055592:Biophysical Phenomena; D000072645:Cancer-Associated Fibroblasts / Q000378:metabolism / Q000473:pathology; D002465:Cell Movement; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D020782:Matrix Metalloproteinases / Q000378:metabolism; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology*; D059748:Proteolysis; D015398:Signal Transduction; D017154:Stromal Cells / Q000378:metabolism / Q000473:pathology; D059016:Tumor Microenvironment
chemical_list: D020782:Matrix Metalloproteinases
keywords: carcinoma-associated fibroblasts; cell movement; extracellular matrix; matrix metalloproteinases; neoplasm invasiveness; stromal cells; tumor microenvironment