title: [Effects on human peripheral erythrocytes of long-term occupational contact with chromate].
abstract: Objective:To investigate the effects on human peripheral blood erythrocytes of long-term occupational contact with chromate.Methods:A dynamic cohort study was conducted of chromate-exposed workers (343 cases) and non-chromate-exposed workers (73 cases) at a chromate production enterprise who were selected according to specific inclusion and exclusion criteria from 2010 to 2015. Personal information and chromate exposure information were obtained by questionnaire. A generalized estimating equation was employed to analyze the effects on human peripheral blood erythrocytes of long-term occupational contact with chromate, controlling for age, gender, smoking, alcohol consumption and body mass index.Results:The mean ages and working ages of those entering the cohort study were 36.67 ±6.78 and 38.47 ± 7.18, respectively, for the exposure group and 8.39 ± 6.02 and 12.86 ± 8.34, respectively, for the control group. The erythrocyte content [(4.73±0.46), (4.81±0.53), (4.41±0.45)]×1012/L in the peripheral blood in the chromate exposure group was lower than that [(4.76±0.42), (4.95±0.45), (4.47±0.39)]×1012/L in the control group for the years 2010, 2011, 2012 and 2014 (tvalues were 0.38, 1.96, 0.92 and 1.21;Pvalues were 0.703, 0.051, 0.358 and 0.227, respectively). The correlations between the years 2010 and 2011, 2011 and 2012, 2012 and 2014, and 2014 and 2015 were 0.667, 0.464,-0.070 and 0.020, respectively (P<0.001). TheRRfor males and those that consumed alcohol were 0.661 (95%CI:0.616-0.709) and 0.910 (95%CI:0.811- 1.201), respectively. Compared with the control group, the risk of reduced erythrocyte levels in the peripheral blood was increased by 0.915 (95%CI:0.852- 0.982) in the chromate-exposed group.Conclusions:The erythrocyte content of peripheral blood was reduced after long-term exposure to chromate. Maleness and alcohol consumption were factors that increased the risk of reduced peripheral blood erythrocytes in the chromate-exposed population.
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, Peking University, Beijing 100191, China.
authors.forename: G P
authors.initials: GP
authors.lastname: Hu
authors.forename: L
authors.initials: L
authors.lastname: Zhao
authors.forename: J X
authors.initials: JX
authors.lastname: Liu
authors.forename: L L
authors.initials: LL
authors.lastname: Wang
authors.forename: Z J
authors.initials: ZJ
authors.lastname: Chen
authors.forename: Y M
authors.initials: YM
authors.lastname: Zhang
authors.forename: L
authors.initials: L
authors.lastname: Wang
authors.forename: Z C
authors.initials: ZC
authors.lastname: Zhao
authors.forename: S F
authors.initials: SF
authors.lastname: Yu
authors.forename: G
authors.initials: G
authors.lastname: Jia
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002840:Chromates / Q000009:adverse effects* / Q000097:blood*; D015331:Cohort Studies; D004912:Erythrocytes / Q000737:chemistry*; D006801:Humans; D008297:Male; D016273:Occupational Exposure / Q000032:analysis*; D012907:Smoking; D011795:Surveys and Questionnaires
chemical_list: D002840:Chromates