title: The relationship between thyroid function and metabolic changes in Chinese women with polycystic ovary syndrome.
abstract: OBJECTIVE
  Aim was to evaluate endocrine, metabolic and thyroid parameters which could help to explore the relationship between thyroid function and metabolic changes in Chinese polycystic ovary syndrome (PCOS) patients.
  
  
  METHODS
  Within a prospective study in PCOS patients compared with healthy women, thyroid parameters were assessed, as well as changes of endocrine, metabolic and clinical characteristics.
  
  
  RESULTS
  144 PCOS patients and 48 normo-ovulatory women matched by age as controls were included. There were significant increases of thyroid-stimulating hormone (TSH), total triiodothyronine (TT3) and total thyroxine (TT4) in the PCOS patients. Body mass index (BMI), waist and hip ratio (WHR), luteinizing hormone (LH), LH/follicle-stimulating hormone (FSH) and total testosterone (T) were significantly higher in PCOS compared with the controls. Total cholesterol (CHO), triglycerides (TG) and apolipoprotein B (ApoB) levels in PCOS were higher, whereas high-density lipoprotein (HDL) and apolipoprotein A (ApoA) were lower compared with the controls. Insulin and homeostatic model assessment of insulin resistance (HOMA-IR) were significantly higher in patients with PCOS.
  
  
  CONCLUSIONS
  Our study confirms the well-known negative metabolic changes in PCOS patients. The small increases of TSH, TT3 and TT4 level may be related with these metabolic changes in PCOS patients. Further studies may improve the understanding of the relationship between thyroid function and metabolic changes.
authors.affiliation: a Department of Gynecological Endocrinology , Beijing Obstetrics and Gynecology Hospital, Capital Medical University , Beijing , China and.
authors.forename: Dongmei
authors.initials: D
authors.lastname: Yin
authors.affiliation: a Department of Gynecological Endocrinology , Beijing Obstetrics and Gynecology Hospital, Capital Medical University , Beijing , China and.|b Department of Women's Health , University Women's Hospital of Tübingen , Tübingen , Germany.
authors.forename: Xiangyan
authors.initials: X
authors.lastname: Ruan
authors.affiliation: a Department of Gynecological Endocrinology , Beijing Obstetrics and Gynecology Hospital, Capital Medical University , Beijing , China and.
authors.forename: Xuanxuan
authors.initials: X
authors.lastname: Tian
authors.affiliation: a Department of Gynecological Endocrinology , Beijing Obstetrics and Gynecology Hospital, Capital Medical University , Beijing , China and.
authors.forename: Juan
authors.initials: J
authors.lastname: Du
authors.affiliation: a Department of Gynecological Endocrinology , Beijing Obstetrics and Gynecology Hospital, Capital Medical University , Beijing , China and.
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: a Department of Gynecological Endocrinology , Beijing Obstetrics and Gynecology Hospital, Capital Medical University , Beijing , China and.
authors.forename: Yamei
authors.initials: Y
authors.lastname: Cui
authors.affiliation: a Department of Gynecological Endocrinology , Beijing Obstetrics and Gynecology Hospital, Capital Medical University , Beijing , China and.
authors.forename: Yanglu
authors.initials: Y
authors.lastname: Li
authors.affiliation: a Department of Gynecological Endocrinology , Beijing Obstetrics and Gynecology Hospital, Capital Medical University , Beijing , China and.|b Department of Women's Health , University Women's Hospital of Tübingen , Tübingen , Germany.
authors.forename: Alfred O
authors.initials: AO
authors.lastname: Mueck
mesh_terms: D000328:Adult; D001054:Apolipoproteins A / Q000097:blood; D001055:Apolipoproteins B / Q000097:blood; D015992:Body Mass Index; D002681:China; D002784:Cholesterol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008075:Lipoproteins, HDL / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D011446:Prospective Studies; D013739:Testosterone / Q000097:blood; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000097:blood*; D014284:Triiodothyronine / Q000097:blood*; D049629:Waist-Hip Ratio; D055815:Young Adult
chemical_list: D001054:Apolipoproteins A; D001055:Apolipoproteins B; D008075:Lipoproteins, HDL; D014284:Triiodothyronine; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin; D002784:Cholesterol; D013974:Thyroxine
keywords: Apolipoprotein; insulin resistance; lipid metabolism; polycystic ovary syndrome; thyroid function