title: Development and optimization of apigenin-loaded transfersomal system for skin cancer delivery: in vitro evaluation.
abstract: The aim of this work is to apply Box-Behnken design to optimize the transfersomes were formulated by modified rotary evaporation sonication technique using surfactant Tween 80. The response surface methodology was used having three-factored with three levels. The prepared formulations were characterized for vesicle shape, size, entrapment efficiency (%), stability, and in vitro permeation. The result showed that drug entrapment of 84.24% with average vesicle size of 35.41 nm and drug loading of 8.042%. Thus, optimized formulation was found good stability and is a promising approach to improve the permeability of apigenin in sustained release for prolonged period of time.
authors.affiliation: a University Institute of Pharmacy, Pt. Ravishankar Shukla University , Raipur (C. G.) , India.
authors.forename: Manmohan Singh
authors.initials: MS
authors.lastname: Jangdey
authors.affiliation: a University Institute of Pharmacy, Pt. Ravishankar Shukla University , Raipur (C. G.) , India.
authors.forename: Anshita
authors.initials: A
authors.lastname: Gupta
authors.affiliation: a University Institute of Pharmacy, Pt. Ravishankar Shukla University , Raipur (C. G.) , India.
authors.forename: Shailendra
authors.initials: S
authors.lastname: Saraf
authors.affiliation: a University Institute of Pharmacy, Pt. Ravishankar Shukla University , Raipur (C. G.) , India.
authors.forename: Swarnlata
authors.initials: S
authors.lastname: Saraf
mesh_terms: D047310:Apigenin / Q000737:chemistry* / Q000378:metabolism / Q000627:therapeutic use; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D010316:Particle Size; D010539:Permeability; D010743:Phospholipids / Q000737:chemistry; D011136:Polysorbates / Q000737:chemistry; D012878:Skin Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D013501:Surface-Active Agents / Q000737:chemistry
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D010743:Phospholipids; D011136:Polysorbates; D013501:Surface-Active Agents; D047310:Apigenin
keywords: Box-Behnken design; Optimization; apigenin; phospholipids; sustained release; transfersomes