title: Antibacterial and anti-biofilm efficacy of fluoropolymer coating by a 2,3,5,6-tetrafluoro-p-phenylenedimethanol structure.
abstract: Fluorinated polymers generally function as antibacterial agents, but their anti-biofilm effect remains unresolved. This study investigates the efficacy of fluoropolymers containing 2,3,5,6-tetrafluoro-p-phenylenedimethanol (TFPDM) in preventing biofilm formation by Bacillus subtilis and Escherichia coli (Gram-positive and Gram-negative bacterial species). To this end, TFPDM-based acrylate and epoxy polymers (AF and EF, respectively) and their structural analogues without TFPDM (A and E, respectively) were synthesized. All polymers were coated onto polyethylene terephthalate (PET) sheets. Relative to pristine PET, sheets coated with AF reduced the initial bacterial adhesion (72h) and biofilm formation (30days) of B. subtilis by 27.6% and 68.7% and of E. coli by 89.2% and 93.8%, respectively. The comparable antibacterial and anti-biofilm efficacies were obtained by sheets with EF. The biofilm detachment was substantially facilitated from the AF, compared with the structural analogue without TFPDM (A). In this comprehensive study, the bacterial adhesion and subsequent biofilm formation were prevented by TFPDM-containing polymers effectively.
authors.affiliation: Department of Chemical Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Naka, Koganei, Tokyo 184-8588, Japan. Electronic address: s150207x@st.go.tuat.ac.jp.
authors.forename: Qian
authors.initials: Q
authors.lastname: Bao
authors.affiliation: Functional Materials Group, Showa Denko K.K., 5-1 Okawa, Kawasaki, Kanagawa 210-0858, Japan. Electronic address: nishimura.norihito.xhzjg@showadenko.com.
authors.forename: Norihito
authors.initials: N
authors.lastname: Nishimura
authors.affiliation: Institute for Integrated Product Development, Showa Denko K.K., 5-1 Okawa, Kawasaki, Kanagawa 210-0858, Japan. Electronic address: kamata.hirotoshi.xhfll@showadenko.com.
authors.forename: Hirotoshi
authors.initials: H
authors.lastname: Kamata
authors.affiliation: Institute for Integrated Product Development, Showa Denko K.K., 5-1 Okawa, Kawasaki, Kanagawa 210-0858, Japan. Electronic address: furue.kentaro.xhfok@showadenko.com.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Furue
authors.affiliation: Institute for Integrated Product Development, Showa Denko K.K., 5-1 Okawa, Kawasaki, Kanagawa 210-0858, Japan. Electronic address: ono.yuki.xhfoz@showadenko.com.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Ono
authors.affiliation: Department of Chemical Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Naka, Koganei, Tokyo 184-8588, Japan. Electronic address: hosomi@cc.tuat.ac.jp.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Hosomi
authors.affiliation: Department of Chemical Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Naka, Koganei, Tokyo 184-8588, Japan. Electronic address: akte@cc.tuat.ac.jp.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Terada
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry*; D001412:Bacillus subtilis / Q000187:drug effects; D001422:Bacterial Adhesion; D018441:Biofilms / Q000187:drug effects*; D004926:Escherichia coli / Q000187:drug effects; D005461:Fluorine / Q000737:chemistry*; D005464:Fluorobenzenes / Q000737:chemistry*; D000432:Methanol / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D011093:Polyethylene Terephthalates / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D033081:Shear Strength; D013314:Stress, Mechanical; D013499:Surface Properties; D041623:Tomography, Optical Coherence
chemical_list: D000900:Anti-Bacterial Agents; D005464:Fluorobenzenes; D011093:Polyethylene Terephthalates; D011108:Polymers; D005461:Fluorine; D000432:Methanol
keywords: Anti-biofilm; Antibacterial; Biofilm heterogeneity; Fluorinated polymer; Optical coherence tomography; Surface properties