title: The role of intestinal microbiota in the pathogenesis of metabolic diseases.
abstract: The incidence of metabolic diseases is increasing rapidly all over the world. This situation has led researchers to attempt to explain the pathomechanisms of these disorders and to develop specific recommendations for the prevention and treatment of diseases such as obesity, type-2 diabetes, and atherosclerosis. Recent studies show clear evidence of the role of human intestinal microbiota in health and in predispositions to diseases. Gut microbiota affect a number of complex metabolic reactions, significantly altering the functioning of the human body. Numerous experiments have shown the key role played by the formation process of the intestinal ecosystem in the early stages of human life for programming its metabolic health. The following article is a compilation of the literature available on the formation of the complex intestinal ecosystem and its impact on the incidence of diseases such as obesity, type-2 diabetes, and atherosclerosis.
authors.affiliation: Department of Human Nutrition and Hygiene, Poznań University of Life Sciences, Poland.
authors.forename: Iwona
authors.initials: I
authors.lastname: Węgielska
authors.affiliation: Department of Human Nutrition and Hygiene, Poznań University of Life Sciences, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Suliburska
mesh_terms: D050197:Atherosclerosis / Q000382:microbiology / Q000517:prevention & control; D003924:Diabetes Mellitus, Type 2 / Q000382:microbiology / Q000517:prevention & control; D002149:Energy Intake; D000069196:Gastrointestinal Microbiome; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000382:microbiology; D008659:Metabolic Diseases / Q000382:microbiology* / Q000517:prevention & control; D009765:Obesity / Q000382:microbiology / Q000517:prevention & control; D011181:Postnatal Care; D056692:Prebiotics; D011295:Prenatal Care; D019936:Probiotics
chemical_list: D056692:Prebiotics
keywords: atherosclerosis; diabetes mellitus; intestinal microbiota; metabolic diseases; obesity