title: Polyacrylic resins regulate transcriptional control of interleukin-6, gp80, and gp130 genes in human gingival fibroblasts.
abstract: Studies have failed to identify the molecular mechanisms that regulate the genotoxic and cytotoxic effects of methacrylate resins, which are important in the biocompatibility of dental materials. Interleukin (IL)-6 has a crucial role in the control of acute-phase protein response during inflammation. In humans, the synthesis and release of two major acute-phase proteins, C-reactive protein and serum amyloid A, are regulated by IL-6. This study focused on IL-6 and activation of its receptors gp80 and gp130 in human gingival fibroblasts in order to assess the effects of the commercial acid resins Jet Kit, Unifast, and Duralay on control of inflammation.
authors.affiliation: Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II Medical School.
authors.forename: Bruna
authors.initials: B
authors.lastname: Borelli
authors.forename: Fernando
authors.initials: F
authors.lastname: Zarone
authors.forename: Virginia
authors.initials: V
authors.lastname: Rivieccio
authors.forename: Francesco
authors.initials: F
authors.lastname: Riccitiello
authors.forename: Michele
authors.initials: M
authors.lastname: Simeone
authors.forename: Roberto
authors.initials: R
authors.lastname: Sorrentino
authors.forename: Sandro
authors.initials: S
authors.lastname: Rengo
authors.forename: Gianrico
authors.initials: G
authors.lastname: Spagnuolo
authors.forename: Alfredo
authors.initials: A
authors.lastname: Procino
mesh_terms: D000180:Acrylic Resins / Q000494:pharmacology*; D002478:Cells, Cultured; D003188:Composite Resins / Q000494:pharmacology*; D050822:Cytokine Receptor gp130 / Q000235:genetics*; D005347:Fibroblasts / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects*; D005881:Gingiva / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D060888:Real-Time Polymerase Chain Reaction; D019947:Receptors, Interleukin-6 / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014158:Transcription, Genetic / Q000187:drug effects*
chemical_list: D000180:Acrylic Resins; D003188:Composite Resins; C508603:IL6R protein, human; D015850:Interleukin-6; D019947:Receptors, Interleukin-6; D050822:Cytokine Receptor gp130; C006903:carbopol 940