title: Questionnaire to assess quality of life in patients with breast cancer - Validation of the Chinese version of the EORTC QLQ-BR 53.
abstract: OBJECTIVE
  To evaluate the reliability and validity of the Chinese version of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Breast Cancer (EORTC QLQ-BR53) questionnaire firstly in north of China.
  
  
  METHODS
  A total of 294 outpatients with breast cancer in Tianjin Cancer Institution and Hospital from November 2014 to August 2015 were enrolled in this study. All patients self-administered the EORTC QLQ-BR25 and the Short Form 36 Health Survey (SF-36). The Eastern Cooperative Oncology Group (ECOG) scoring was performed to evaluate scores. Internal consistency reliability was determined by Cronbach's α coefficient for each dimension, with a Cronbach's α coefficient ≥0.7 considered to be statistically significant.
  
  
  RESULTS
  A satisfactory internal consistency reliability for most multi-item scales was confirmed, as Cronbach's α coefficients were close or greater than 0.7 except for breast symptoms (0.615). Multiple-trait scaling analysis demonstrated a good convergent and divergent validity of EORTC QLQ-BR53. Using SF-36 as a reference standard to evaluate the dimensions of EORTC QLQ-BR53, most items in EORTC QLQ-BR53 possessed a favorable correlation with its own dimension (r > 0.4). A statistically significant difference was discovered in dimension scores between patients grouped by ECOG scores except for individual dimensions.
  
  
  CONCLUSIONS
  The Chinese version of EORTC QLQ-BR53 is a reliable and valid instrument for measuring the quality of life among Chinese patients with breast cancer.
authors.affiliation: Department of Oncology, Third Xiangya Hospital, Central South University, Changsha, People's Republic of China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Xiangya Medical School, Central South University, Changsha, People's Republic of China.
authors.forename: Xian
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Xiangya Medical School, Central South University, Changsha, People's Republic of China.
authors.forename: Ling
authors.initials: L
authors.lastname: Wei
authors.affiliation: Tianjin Medical University, Tianjin, People's Republic of China.
authors.forename: Yunshou
authors.initials: Y
authors.lastname: Lin
authors.affiliation: Xiangya Medical School, Central South University, Changsha, People's Republic of China.
authors.forename: Dongwen
authors.initials: D
authors.lastname: Wu
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, The Xiangya Hospital, Central South University, Changsha, People's Republic of China.
authors.forename: Shumin
authors.initials: S
authors.lastname: Xie
authors.affiliation: Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Outpatient Service, Tianjin, People's Republic of China.
authors.forename: Lin
authors.initials: L
authors.lastname: Yue
authors.affiliation: Xiangya Medical School, Central South University, Changsha, People's Republic of China.
authors.forename: Jingru
authors.initials: J
authors.lastname: Tian
authors.affiliation: Tianjin Medical University, Tianjin, People's Republic of China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Tianjin Medical University, Tianjin, People's Republic of China.
authors.forename: Qijun
authors.initials: Q
authors.lastname: Song
authors.affiliation: Harvard University, Cambridge, MA, USA.
authors.forename: Stephenie Mu-Lian
authors.initials: SM
authors.lastname: Woo
authors.affiliation: Indiana University School of Medicine, Indianapolis, IN, USA.
authors.forename: Adam R
authors.initials: AR
authors.lastname: Miller
authors.affiliation: Department of Radiation Oncology, Tumor Hospital Xiangya School of Medicine of Central South University, Changsha, People's Republic of China.
authors.forename: Le
authors.initials: L
authors.lastname: Luo
authors.affiliation: Department of Thoracic Surgery, Key Laboratory of Cancer Prevention and Therapy, Tianjin Lung Cancer Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, People's Republic of China. Electronic address: raymd728@qq.com.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000523:psychology*; D002681:China; D005260:Female; D006801:Humans; D007802:Language; D008875:Middle Aged; D011594:Psychometrics; D011788:Quality of Life; D015203:Reproducibility of Results; D018434:Sickness Impact Profile; D011795:Surveys and Questionnaires / Q000592:standards*; D014177:Translations
keywords: Breast cancer; EORTC QLQ-BR53; Quality of life; Validation