title: Comparison of "Nil by Mouth" Versus Early Oral Intake in Three Different Diet Regimens Following Esophagectomy.
abstract: The literature on oral intake after esophagectomy and its influence on anastomotic leakage and complications is sparse.
  
  
  
  This retrospective study included 359 patients undergoing esophagectomy between January 2011 and August 2015. Three oral intake protocols were evaluated: regimen 1, nil by mouth until postoperative day (POD) 7 followed by a normal diet; regimen 2, oral intake of clear fluids from POD 1 followed by a normal diet; regimen 3, nil by mouth until POD 7 followed by a slow increase to a blended diet. The outcome endpoints were: (1) anastomotic leakage, (2) complications [severity and number described using the Dindo-Clavien Classification and Comprehensive Complication Index (CCI)] and (3) length of stay. A multivariate logistic regression model was obtained for CCI and anastomotic leakage using Wald's stepwise selection.
  
  
  
  CCI was significantly lower in regimen 3 (16 vs. 22 and 26 in regimen 1 and 2, p = 0.027). Additionally, significantly fewer patients in regimen 3 suffered from severe complications of Dindo-Clavien grade IIIb-IV (p = 0.025). The incidence of anastomotic leakage reached its lowest in regimen 3, 2%, compared to 7-9%. Multivariate analyses revealed that high American Society of Anesthesiologist score was a predicting factor for both CCI and anastomotic leakage.
  
  
  
  The study indicates that nil by mouth until postoperative day 7 followed by a slow increase to a blended diet after esophagectomy results in less severe complications and a tendency of fewer anastomotic leakages. Multiple comorbidities proved to be an important predictive factor of the postoperative course.
authors.affiliation: Department of Surgical Gastroenterology, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark. kristine.eberhard@gmail.com.|Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, 2200, Copenhagen, Denmark. kristine.eberhard@gmail.com.
authors.forename: Kristine Elisabeth
authors.initials: KE
authors.lastname: Eberhard
authors.affiliation: Department of Surgical Gastroenterology, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark.|Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, 2200, Copenhagen, Denmark.
authors.forename: Michael Patrick
authors.initials: MP
authors.lastname: Achiam
authors.affiliation: Department of Surgical Gastroenterology, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark.
authors.forename: Hans Christian
authors.initials: HC
authors.lastname: Rolff
authors.affiliation: Department of Surgical Gastroenterology, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark.|Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, 2200, Copenhagen, Denmark.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Belmouhand
authors.affiliation: Department of Surgical Gastroenterology, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark.|Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, 2200, Copenhagen, Denmark.
authors.forename: Lars Bo
authors.initials: LB
authors.lastname: Svendsen
authors.affiliation: Department of Surgical Gastroenterology, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark.
authors.forename: Morten
authors.initials: M
authors.lastname: Thorsteinsson
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D057868:Anastomotic Leak / Q000453:epidemiology / Q000209:etiology; D004032:Diet; D016629:Esophagectomy / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007902:Length of Stay; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009055:Mouth; D012189:Retrospective Studies