title: Bolus dose of epinephrine for refractory post-arrest hypotension.
abstract: Post-cardiac arrest hypotension is associated with worse outcomes. However, a significant proportion of patients may not be responsive to intravenous (IV) fluids, and vasopressor infusions require significant time to initiate. This case series describes the successful use of a bolus dose of epinephrine to rapidly treat IV fluid refractory hypotension among three patients in the post-arrest period. A bolus dose of epinephrine may be considered as a treatment for post-arrest hypotension that does not respond to IV fluids, but further studies should be performed prior to routine use.
authors.affiliation: *Department of Emergency Medicine,Rush University Medical Center,Chicago,IL.
authors.forename: Michael
authors.initials: M
authors.lastname: Gottlieb
mesh_terms: D000368:Aged; D004837:Epinephrine / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007022:Hypotension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D058687:Out-of-Hospital Cardiac Arrest; D014662:Vasoconstrictor Agents / Q000008:administration & dosage*
chemical_list: D014662:Vasoconstrictor Agents; D004837:Epinephrine
keywords:  hypotension;  pressors;  push dose;  vasopressors; bolus dose; cardiac arrest; epinephrine