title: Intraocular inflammatory mass associated with lens-induced uveitis.
abstract: Intraocular inflammatory tumefactions large enough to simulate neoplasms are uncommon. We report a patient with a large intraocular inflammatory mass composed of cells with features of histiocytes and myofibroblasts that was associated with lens-induced uveitis. The spindle cell mass appears to have arisen as an exaggerated response to exposed lens fibers. Although information from immunohistochemistry and cytogenetics has advanced the classification of inflammatory tumefactions, this case highlights the challenges in establishing the nature of these lesions.
authors.affiliation: Department of Pathology, James A. Haley Veterans Affairs Hospital, Tampa, Florida, USA.
authors.forename: Jean
authors.initials: J
authors.lastname: Guffey Johnson
authors.affiliation: Department of Pathology and Cell Biology, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA; Department of Ophthalmology, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA. Electronic address: cmargo@health.usf.edu.
authors.forename: Curtis E
authors.initials: CE
authors.lastname: Margo
mesh_terms: D003937:Diagnosis, Differential; D006801:Humans; D007910:Lenses, Intraocular / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D016727:Orbital Pseudotumor / Q000175:diagnosis / Q000209:etiology*; D014605:Uveitis / Q000150:complications* / Q000175:diagnosis
keywords: anaplastic lymphoma kinase; inflammatory myofibroblastic tumor; inflammatory pseudotumor; intraocular pseudotumor; lens-induced uveitis; phacoantigenic uveitis