title: The relationship between central visual field sensitivity and macular ganglion cell/inner plexiform layer thickness in glaucoma.
abstract: To explore the correlation of local macular ganglion cell/inner plexiform layer (GC/IPL) thickness measurements with sensitivity at individual test locations on the central 10-2 visual fields (VFs) in patients with glaucoma.
  
  
  
  One hundred thirty-seven eyes of 125 patients with spectral domain optical coherence tomography (OCT) and 10-2 VFs were included. The exported thickness matrices (200×200) of GC/IPL measurements were centred on the fovea. Total deviation values at each test location were correlated with the 20 000 GC/IPL thickness measurements in the corresponding inferior or superior hemiretina, and areas of highest correlation were plotted. Macular structure-function relationships were also examined between six wedge-shaped GC/IPL sectors and the corresponding VF clusters. A multivariate model was built to identify the 10-2 VF test locations associated with each GC/IPL sector thickness.
  
  
  
  Average mean deviation on 10-2 VFs was -9.2±6.1 dB. The 10-2 VF test points demonstrated correlations with GC/IPL thickness in localised arcuate patterns mostly limited within the central 4.8×4.0 mm measurement ellipse (ρ=0.43-0.74, p<0.05 for all). Twenty-one test points of the 10-2 VF were the best predictors of sectoral GC/IPL thickness. Sectoral VF-OCT correlations were high (ρ=0.53-0.66, p<0.001) and did not significantly change after adjusting for retinal GC displacement (p>0.05).
  
  
  
  Macular OCT/VF relationships have localised arcuate characteristics in the central region of the macula. Given the overlapping nature of structure-function relationships, a smaller number of VF test locations may be used to summarise macular functional damage.
  
  
  
  NCT01742819.
authors.affiliation: Glaucoma Division, Stein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, California, USA.|Department of Ophthalmology, Pusan National University College of Medicine, Busan, South Korea.
authors.forename: Ji-Woong
authors.initials: JW
authors.lastname: Lee
authors.affiliation: Glaucoma Division, Stein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
authors.forename: Esteban
authors.initials: E
authors.lastname: Morales
authors.affiliation: Glaucoma Division, Stein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, California, USA.|Department of Ophthalmology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
authors.forename: Farideh
authors.initials: F
authors.lastname: Sharifipour
authors.affiliation: Glaucoma Division, Stein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
authors.forename: Navid
authors.initials: N
authors.lastname: Amini
authors.affiliation: Glaucoma Division, Stein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, California, USA.|Department of Biostatistics, Jonathan and Karin Fielding School of Public Health at UCLA, Los Angeles, California, USA.
authors.forename: Fei
authors.initials: F
authors.lastname: Yu
authors.affiliation: Department of Biostatistics, Jonathan and Karin Fielding School of Public Health at UCLA, Los Angeles, California, USA.
authors.forename: Abdelmonem A
authors.initials: AA
authors.lastname: Afifi
authors.affiliation: Glaucoma Division, Stein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
authors.forename: Anne L
authors.initials: AL
authors.lastname: Coleman
authors.affiliation: Glaucoma Division, Stein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
authors.forename: Joseph
authors.initials: J
authors.lastname: Caprioli
authors.affiliation: Glaucoma Division, Stein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
authors.forename: Kouros
authors.initials: K
authors.lastname: Nouri-Mahdavi
mesh_terms: D000368:Aged; D005260:Female; D005584:Fovea Centralis / Q000473:pathology; D005901:Glaucoma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D008266:Macula Lutea / Q000000981:diagnostic imaging / Q000473:pathology* / Q000502:physiology; D008297:Male; D012164:Retinal Diseases / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D012165:Retinal Ganglion Cells / Q000473:pathology*; D041623:Tomography, Optical Coherence; D014794:Visual Fields / Q000502:physiology*
keywords: Field of vision; Glaucoma; Macula