title: Daily Variation of UV-induced Erythema and the Action of Solar Filters.
abstract: UV rays may cause several degrees of skin damage, which makes sunscreen research necessary. In addition, skin sensitivity shows daily variations, which can interfere in the detection of the efficacy of the filters. Here, we studied the UV-induced erythema in hairless rats at two times of the day (light and darkness) using a colorimeter method. The effect of an emulsion with solar filters with or without melatonin was also assayed. Results indicate that the value of a* (from CIELAB color space values L* a* b) was the most useful variable to evaluate the erythema. However, at the UV intensity used, erythema was only detected when irradiation was carried out during the activity phase of the animal, enabling the detection of the protective action of the sunscreen at this time. Thus, daily variations in skin sensitivity have been demonstrated and should be taken into account in dermatological research.
authors.affiliation: Departament de Farmàcia i Tecnologia Farmacéutica, Facultat de Farmàcia i Ciències de la Alimentació, Universitat de Barcelona, Barcelona, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Flo
authors.affiliation: Departament de Farmàcia i Tecnologia Farmacéutica, Facultat de Farmàcia i Ciències de la Alimentació, Universitat de Barcelona, Barcelona, Spain.
authors.forename: Ana C
authors.initials: AC
authors.lastname: Calpena
authors.affiliation: Departament de Fisiologia i Bioquímica, Facultat de Farmàcia i Ciències de la Alimentació, Universitat de Barcelona, Barcelona, Spain.
authors.forename: Antoni
authors.initials: A
authors.lastname: Díez-Noguera
authors.affiliation: Departament de Farmàcia i Tecnologia Farmacéutica, Facultat de Farmàcia i Ciències de la Alimentació, Universitat de Barcelona, Barcelona, Spain.
authors.forename: Alfons
authors.initials: A
authors.lastname: Del Pozo
authors.affiliation: Departament de Fisiologia i Bioquímica, Facultat de Farmàcia i Ciències de la Alimentació, Universitat de Barcelona, Barcelona, Spain.
authors.forename: Trinitat
authors.initials: T
authors.lastname: Cambras
mesh_terms: D000818:Animals; D002940:Circadian Rhythm; D003124:Colorimetry; D004890:Erythema / Q000209:etiology* / Q000517:prevention & control; D008297:Male; D008550:Melatonin / Q000008:administration & dosage; D017207:Rats, Sprague-Dawley; D013473:Sunscreening Agents; D014466:Ultraviolet Rays
chemical_list: D013473:Sunscreening Agents; D008550:Melatonin