title: Capturing norovirus transmission.
abstract: Human norovirus is a leading cause of gastroenteritis and is efficiently transmitted between humans and around the globe. The burden of norovirus infections in the global community and in health-care settings warrant the availability of outbreak prevention strategies and control measures that are tailored to the pathogen, outbreak setting and population at risk. A better understanding of viral and host determinants of transmission would aid in developing and fine-tuning such efforts. Here, we describe mechanisms of transmission, available model systems for studying norovirus transmission and their strengths and weaknesses as well as future research strategies.
authors.affiliation: Department of Viroscience, Erasmus Medical Center, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands. Electronic address: m.degraaf@erasmusmc.nl.
authors.forename: Miranda
authors.initials: M
authors.lastname: de Graaf
authors.affiliation: Department of Viroscience, Erasmus Medical Center, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands.
authors.forename: Nele
authors.initials: N
authors.lastname: Villabruna
authors.affiliation: Department of Viroscience, Erasmus Medical Center, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands.
authors.forename: Marion Pg
authors.initials: MP
authors.lastname: Koopmans
mesh_terms: D017250:Caliciviridae Infections / Q000517:prevention & control* / Q000635:transmission*; D018562:Disease Transmission, Infectious / Q000517:prevention & control*; D005759:Gastroenteritis / Q000517:prevention & control* / Q000821:virology*; D006801:Humans; D029322:Norovirus / Q000302:isolation & purification*