title: A Health-Related Quality-of-Life Measure for Use in Patients with HIV: A Validation Study.
abstract: In the United States, HIV has evolved from an acute disease to a chronic illness making health-related quality of life a pre-eminent goal for many persons living with HIV (PLWH). There have been a number of HIV-specific quality-of-life instruments developed, but little attention has been paid to the validation of standardized nondisease-specific quality-of-life instruments tailored to PLWH. The goal of this research was to validate the Patient-Reported Outcomes Measurement Information System (PROMIS)-29, a questionnaire that measures health-related quality of life in PLWH. A sample of 1306 PLWH completed an online anonymous survey assessing their symptom experience and health-related quality of life. A subsample of 209 participants completed another questionnaire 30 days later. The subscales of the PROMIS-29 showed high internal consistency reliability (range = 0.87-0.97). The PROMIS-29 detected differences in health-related quality of life in those persons who reported an AIDS diagnosis compared to those who did not report an AIDS diagnosis. The PROMIS-29 has demonstrated reliability, validity, and reproducibility for use in measuring health-related quality of life in PLWH.
authors.affiliation: 1 School of Nursing, Columbia University , New York, New York.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Schnall
authors.affiliation: 1 School of Nursing, Columbia University , New York, New York.
authors.forename: Jianfang
authors.initials: J
authors.lastname: Liu
authors.affiliation: 1 School of Nursing, Columbia University , New York, New York.
authors.forename: Hwayoung
authors.initials: H
authors.lastname: Cho
authors.affiliation: 2 Public Health Solutions , New York, New York.
authors.forename: Sabina
authors.initials: S
authors.lastname: Hirshfield
authors.affiliation: 3 Department of Sociomedical Sciences, Mailman School of Public Health, Columbia University , New York, New York.
authors.forename: Karolynn
authors.initials: K
authors.lastname: Siegel
authors.affiliation: 4 Division of Infectious Diseases, Department of Medicine, Columbia University Medical Center , New York, New York.
authors.forename: Susan
authors.initials: S
authors.lastname: Olender
mesh_terms: D000328:Adult; D000368:Aged; D002908:Chronic Disease / Q000523:psychology; D005260:Female; D015658:HIV Infections / Q000523:psychology*; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D063868:Patient Outcome Assessment; D000071066:Patient Reported Outcome Measures; D018802:Patient-Centered Care / Q000379:methods*; D011594:Psychometrics; D011788:Quality of Life / Q000523:psychology*; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires; D013997:Time Factors; D014481:United States
keywords: HIV; PROMIS; health-related quality of life; psychometric evaluation