title: Innovative Approaches to Improve Anti-Infective Vaccine Efficacy.
abstract: Safe and efficacious vaccines are arguably the most successful medical interventions of all time. Yet the ongoing discovery of new pathogens, along with emergence of antibiotic-resistant pathogens and a burgeoning population at risk of such infections, imposes unprecedented public health challenges. To meet these challenges, innovative strategies to discover and develop new or improved anti-infective vaccines are necessary. These approaches must intersect the most meaningful insights into protective immunity and advanced technologies with capabilities to deliver immunogens for optimal immune protection. This goal is considered through several recent advances in host-pathogen relationships, conceptual strides in vaccinology, and emerging technologies. Given a clear and growing risk of pandemic disease should the threat of infection go unmet, developing vaccines that optimize protective immunity against high-priority and antibiotic-resistant pathogens represents an urgent and unifying imperative.
authors.affiliation: Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90024.|Division of Molecular Medicine, Department of Medicine, Harbor-UCLA Medical Center, Torrance, California 90509; email: MRYeaman@ucla.edu.|Division of Infectious Diseases, Department of Medicine, Harbor-UCLA Medical Center, Torrance, California 90509.|Los Angeles Biomedical Research Institute, Torrance, California 90502.
authors.forename: Michael R
authors.initials: MR
authors.lastname: Yeaman
authors.affiliation: NovaDigm Therapeutics, Inc., Grand Forks, North Dakota 58202.
authors.forename: John P
authors.initials: JP
authors.lastname: Hennessey
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000276:immunology / Q000378:metabolism; D003141:Communicable Diseases / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects / Q000502:physiology; D062069:Inventions / Q000639:trends*; D016896:Treatment Outcome; D014612:Vaccines / Q000008:administration & dosage* / Q000276:immunology / Q000378:metabolism
chemical_list: D000890:Anti-Infective Agents; D014612:Vaccines
keywords: adjuvant; antibiotic resistance; immunity; immunotherapy; innovation; pathogen; vaccine