title: Metronomic Chemotherapy: Seems Prowess to Battle against Cancer in Current Scenario.
abstract: BACKGROUND
  Metronomic chemotherapy is an emerging method of chemotherapy. Metronomic 'lowdose' chemotherapy regimen induces tumour dormancy and reduces cancer resistance against anticancer drugs. It tends to improve overall success rate of cancer chemotherapy than conventional cyclical regimen.
  
  
  OBJECTIVE
  The aim of this systemic review was to provide comprehensive data of metronomic chemotherapy trials, regimens used and it's outcome in cancer therapeutics.
  
  
  METHODS
  Fifty chemotherapy trial data were searched sequentially from web. The main sources were official website of Clinical trial forum, USA and Clinical Trial Registry India (CTRI). Evidence on efficacy and safety of such metronomic chemotherapy trials was gathered from various data published in Medline, New England Journal of Medicine (NEJM), Lancet Oncology and other journals with high credentials. As a result of our search, out of 50 trials including breast -15(30%), colon-, 5(10%) ovarian -5(10%), prostate-5(10%) and others including haematologic, soft tissue and nervous system malignancies -20 (50%). Twenty seven trials showed favourable, 20 trials showed equivocal outcome and 3 trials reported unfavourable outcome. Overall comparison showed definitive statistical significance for using metronomic regimen (p-0.05).
  
  
  CONCLUSIONS
  It can be concluded that metronomic chemotherapy regimen seems convincing beneficial to induce tumour remission and survival at a higher than conventional regimen. More metanalyses are needed to frame common metronomic chemotherapeutic regimen.
authors.affiliation: Postgraduate, Department of Pharmacology, Haasan Institute of Medical Sciences , Haasan, Karanataka, India .
authors.forename: Prema
authors.initials: P
authors.lastname: Muthusamy
authors.affiliation: Assistant Professor, Department of Pharmacology, Saveetha Medical College , Chennai, Tamil Nadu, India .
authors.forename: Krishnan Vengadaragava
authors.initials: KV
authors.lastname: Chary
authors.affiliation: Professor, Department of Pharmacology, Haasan Institute of Medical Sciences , Haasan, Karanataka, India .
authors.forename: G K
authors.initials: GK
authors.lastname: Nalini
keywords: Cancer resistance; Low dose chemotherapy; Maintenance chemotherapy