title: Function of obestatin in the digestive system.
abstract: Physical health has a direct relationship with digestive function. Any abnormalities in the link may cause malnutrition, endocrine disorders, and the decline of organ functions. Obestatin, a biologically active peptide, is encoded by the ghrelin gene. Most studies suggest that obestatin is a pleiotropic peptide, which acts by suppressing the motility of the gastrointestinal tract, regulating the secretion of insulin, reducing inflammation and apoptosis, and promoting proliferation. These characteristics suggest that obestatin may represent an efficient way to prevent the occurrence and development of some digestive diseases. However, the functions of obestatin are not clear, and even appear to be contradictory. The aim of this review was to discuss the close relationship between obestatin and the digestive system, and to provide a unique perspective for the future development of obestatin relative to digestive diseases.
authors.affiliation: Department of Endocrinology, The First Clinical Hospital of Harbin Medical University, Harbin, China.
authors.forename: Yue-Xian
authors.initials: YX
authors.lastname: Xing
authors.affiliation: Department of Endocrinology, The First Clinical Hospital of Harbin Medical University, Harbin, China.
authors.forename: Liu
authors.initials: L
authors.lastname: Yang
authors.affiliation: Department of Endocrinology, The First Clinical Hospital of Harbin Medical University, Harbin, China.
authors.forename: Hong-Yu
authors.initials: HY
authors.lastname: Kuang
authors.affiliation: Department of Endocrinology, The First Clinical Hospital of Harbin Medical University, Harbin, China. Electronic address: 15369337970@163.com.
authors.forename: Xin-Yuan
authors.initials: XY
authors.lastname: Gao
authors.affiliation: Department of Endocrinology, The First Clinical Hospital of Harbin Medical University, Harbin, China.
authors.forename: Hao-Ling
authors.initials: HL
authors.lastname: Liu
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D003092:Colitis / Q000188:drug therapy; D004195:Disease Models, Animal; D005767:Gastrointestinal Diseases / Q000188:drug therapy; D005769:Gastrointestinal Motility / Q000187:drug effects* / Q000502:physiology; D041981:Gastrointestinal Tract / Q000187:drug effects* / Q000502:physiology; D054439:Ghrelin / Q000494:pharmacology*; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D008099:Liver / Q000187:drug effects / Q000502:physiology; D010182:Pancreatic Diseases / Q000188:drug therapy; D010195:Pancreatitis / Q000188:drug therapy; D014456:Ulcer / Q000188:drug therapy
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D054439:Ghrelin; D007328:Insulin
keywords: Gastrointestinal; Insulin; Movement; Pancreatitis; Ulcer