title: Quantitative EEG After Brain Stimulation and Cognitive Training in Alzheimer Disease.
abstract: OBJECTIVE
  Medications are the currently accepted symptomatic treatment of Alzheimer disease (AD), but their impact on delaying the progression of cognitive deficits and functional impairment is limited. The authors aimed to explore long-term electrophysiological effects of repetitive transcranial magnetic stimulation interlaced with cognitive training on quantitative electroencephalography (EEG) in patients with AD.
  
  
  METHODS
  Quantitative EEG was assessed on non-repetitive transcranial magnetic stimulation interlaced with cognitive training treatment days before treatment and after each treatment phase in seven patients with mild AD.
  
  
  RESULTS
  After 4.5 months (54 sessions) of treatment, a significant increase of delta activity over the temporal region was found compared with pretreatment values. Nonsignificant increases of the log EEG power were found for alpha band over the frontal and temporal regions, beta band over the frontal region, theta band over the frontal, temporal, and parieto-occipital regions, and delta band over the frontal and parieto-occipital regions. Nonsignificant decreases were found for alpha over the parieto-occipital region, and for beta over the temporal and parieto-occipital regions. A positive correlation was found between log alpha power over the frontal and temporal regions at 6 weeks and Mini-Mental State Examination (MMSE) scores at 6 weeks and 4.5 months, and between log alpha power over the parieto-occipital regions and MMSE scores at 6 weeks. A negative correlation was found between log alpha power over the frontal and temporal regions at 6 weeks and baseline Alzheimer's Disease Assessment Scale-cognitive subscale scores.
  
  
  CONCLUSIONS
  Repetitive transcranial magnetic stimulation interlaced with cognitive training has long-term effects on quantitative EEG in patients with mild AD. Further research on the quantitative EEG long-term effects of transcranial magnetic stimulation interlaced with cognitive training is required to confirm the authors' data.
authors.affiliation: *Department of Neurology, Assaf Harofeh Medical Center, Zerifin, Israel; and †Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
authors.forename: Revital
authors.initials: R
authors.lastname: Gandelman-Marton
authors.forename: Sergio
authors.initials: S
authors.lastname: Aichenbaum
authors.forename: Evgenya
authors.initials: E
authors.lastname: Dobronevsky
authors.forename: Michael
authors.initials: M
authors.lastname: Khaigrekht
authors.forename: Jose M
authors.initials: JM
authors.lastname: Rabey
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000628:therapy*; D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology*; D015928:Cognitive Behavioral Therapy / Q000379:methods; D003131:Combined Modality Therapy / Q000379:methods; D004569:Electroencephalography / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008609:Mental Status Schedule; D009483:Neuropsychological Tests; D012720:Severity of Illness Index; D012815:Signal Processing, Computer-Assisted; D013997:Time Factors; D050781:Transcranial Magnetic Stimulation / Q000379:methods; D016896:Treatment Outcome