title: Incidence of acute intussusception among infants in eastern France: results of the EPIstudy trial.
abstract: The incidence of intussusception in infants varies around the world. The epidemiology of intussusception in France has never been prospectively studied. We performed a prospective observational study with systematic inclusion of all infants aged <1 year with suspected intussusception admitted to the emergency departments of the hospitals in the eastern region of France (98,000 live births per year), from 4/1/2008 to 3/31/2012. Cases were classified using the Brighton Collaboration classification. In total, 185 infants with suspected intussusception were included of which 169 were idiopathic intussusception. Among these 169 cases, 115 (68%) were classed as Brighton level 1 (confirmed cases). Overall incidence of intussusception over the 4 years of the study was 29.8 (95% CI 24.6-35.7) cases per 100,000 live births for level 1 and 37.5 (95% CI 31.7-44.2) cases per 100,000 live births for all cases (levels 1-4). Annual incidence rates of level 1 intussusception were as follows: 44 (95% CI 31.9-59.3), 30.9 (20.9-44.2), 21.7 (13.4-33.2) and 22.1 (13.7-33.8) per 100,000 live births in the 1st, 2nd, 3rd and 4th study years, respectively.
  
  
  CONCLUSIONS
  The incidence rate of intussusception in the eastern part of France is comparable to that of other European countries. There was a significant trend towards a decrease in the incidence of intussusception. What is known • Intussusception is the most frequent causes of intestinal obstruction in infants and young children. Overall incidence of intussusception in infants aged <1 year varies widely around the world. No specific epidemiological studies have not been conducted in France on intussusception. What is new: • This prospective and multicenter study provides important information about the epidemiology of intussusception in infants in France over a period of 4 years.
authors.affiliation: Department of Pediatric Surgery, Besançon University Hospital, 3 boulevard Fleming, 25000, Besançon, France. afotsokamdem@chu-besancon.fr.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Fotso Kamdem
authors.affiliation: INSERM-CIC-1431, Besançon University Hospital, 2 place Saint Jacques, 25000, Besançon, France.
authors.forename: Chrystelle
authors.initials: C
authors.lastname: Vidal
authors.affiliation: INSERM-CIC-1431, Besançon University Hospital, 2 place Saint Jacques, 25000, Besançon, France.
authors.forename: Lionel
authors.initials: L
authors.lastname: Pazart
authors.affiliation: INSERM-CIC-1431, Besançon University Hospital, 2 place Saint Jacques, 25000, Besançon, France.
authors.forename: Franck
authors.initials: F
authors.lastname: Leroux
authors.affiliation: INSERM-CIC-1431, Besançon University Hospital, 2 place Saint Jacques, 25000, Besançon, France.
authors.forename: Aurore
authors.initials: A
authors.lastname: Pugin
authors.affiliation: Phisquare Institute, Fondation Transplantation, 20 rue Saint Saëns, 75015, Paris, France.
authors.forename: Caroline
authors.initials: C
authors.lastname: Savet
authors.affiliation: Phisquare Institute, Fondation Transplantation, 20 rue Saint Saëns, 75015, Paris, France.
authors.forename: Geoffroy
authors.initials: G
authors.lastname: Sainte-Claire Deville
authors.affiliation: Phisquare Institute, Fondation Transplantation, 20 rue Saint Saëns, 75015, Paris, France.
authors.forename: Lionel
authors.initials: L
authors.lastname: Riou França
authors.affiliation: INSERM UMR 1181 « Biostatistics, Biomathematics, Pharmacoepidemiology and Infectious Diseases » (B2PHI), 75015, Paris, France.|Institut Pasteur, UMR 1181, B2PHI, 75015, Paris, France.|University of Versailles St Quentin, UMR 1181, B2PHI, 78180, Montigny-le-Bretonneux, France.|AP-HP, Raymond Poincare Hospital, 92380, Garches, France.
authors.forename: Didier
authors.initials: D
authors.lastname: Guillemot
authors.affiliation: INSERM-CIC-1431, Besançon University Hospital, 2 place Saint Jacques, 25000, Besançon, France.|Phisquare Institute, Fondation Transplantation, 20 rue Saint Saëns, 75015, Paris, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Massol
mesh_terms: D000208:Acute Disease; D004636:Emergency Service, Hospital / Q000706:statistics & numerical data; D005260:Female; D005602:France / Q000453:epidemiology; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007443:Intussusception / Q000453:epidemiology*; D008297:Male; D011446:Prospective Studies; D012042:Registries
keywords: Brighton collaboration criteria; Incidence rate; Infants; Intussuception