title: Enhanced visualization of peripheral retinal vasculature with wavefront sensorless adaptive optics optical coherence tomography angiography in diabetic patients.
abstract: Optical coherence tomography angiography (OCTA) is a promising technique for non-invasive visualization of vessel networks in the human eye. We debut a system capable of acquiring wide field-of-view (>70°) OCT angiograms without mosaicking. Additionally, we report on enhancing the visualization of peripheral microvasculature using wavefront sensorless adaptive optics (WSAO). We employed a fast WSAO algorithm that enabled wavefront correction in <2  s by iterating the mirror shape at the speed of OCT B-scans rather than volumes. Also, we contrasted ∼7° field-of-view OCTA angiograms acquired in the periphery with and without WSAO correction. On average, WSAO improved the sharpness of microvasculature by 65% in healthy eyes and 38% in diseased eyes. Preliminary observations demonstrated that the location of 7° images could be identified directly from the wide field-of-view angiogram. A pilot study on a normal subject and patients with diabetic retinopathy showed the impact of utilizing WSAO for OCTA when visualizing peripheral vasculature pathologies.
authors.forename: James
authors.initials: J
authors.lastname: Polans
authors.forename: David
authors.initials: D
authors.lastname: Cunefare
authors.forename: Eli
authors.initials: E
authors.lastname: Cole
authors.forename: Brenton
authors.initials: B
authors.lastname: Keller
authors.forename: Priyatham S
authors.initials: PS
authors.lastname: Mettu
authors.forename: Scott W
authors.initials: SW
authors.lastname: Cousins
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Allingham
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Izatt
authors.forename: Sina
authors.initials: S
authors.lastname: Farsiu
mesh_terms: D000328:Adult; D003930:Diabetic Retinopathy / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D055095:Optics and Photonics; D010865:Pilot Projects; D012160:Retina; D012171:Retinal Vessels; D041623:Tomography, Optical Coherence / Q000379:methods*