title: Transportable hyperpolarized metabolites.
abstract: Nuclear spin hyperpolarization of13C-labelled metabolites by dissolution dynamic nuclear polarization can enhance the NMR signals of metabolites by several orders of magnitude, which has enabled in vivo metabolic imaging by MRI. However, because of the short lifetime of the hyperpolarized magnetization (typically <1 min), the polarization process must be carried out close to the point of use. Here we introduce a concept that markedly extends hyperpolarization lifetimes and enables the transportation of hyperpolarized metabolites. The hyperpolarized sample can thus be removed from the polarizer and stored or transported for use at remote MRI or NMR sites. We show that hyperpolarization in alanine and glycine survives 16 h storage and transport, maintaining overall polarization enhancements of up to three orders of magnitude.
authors.affiliation: Ecole Polytechnique Fédérale de Lausanne, Institut des Sciences et Ingénierie Chimiques, Lausanne 1015, Switzerland.
authors.forename: Xiao
authors.initials: X
authors.lastname: Ji
authors.affiliation: Ecole Polytechnique Fédérale de Lausanne, Institut des Sciences et Ingénierie Chimiques, Lausanne 1015, Switzerland.
authors.forename: Aurélien
authors.initials: A
authors.lastname: Bornet
authors.affiliation: Ecole Polytechnique Fédérale de Lausanne, Institut des Sciences et Ingénierie Chimiques, Lausanne 1015, Switzerland.
authors.forename: Basile
authors.initials: B
authors.lastname: Vuichoud
authors.affiliation: Ecole Polytechnique Fédérale de Lausanne, Institut des Sciences et Ingénierie Chimiques, Lausanne 1015, Switzerland.
authors.forename: Jonas
authors.initials: J
authors.lastname: Milani
authors.affiliation: Univ Lyon, CNRS, Université Claude Bernard Lyon 1, ENS de Lyon, Institut des Sciences Analytiques, UMR 5280, 5 rue de la Doua, 69100 Villeurbanne, France.
authors.forename: David
authors.initials: D
authors.lastname: Gajan
authors.affiliation: Ecole Polytechnique Fédérale de Lausanne, Institut des Sciences et Ingénierie Chimiques, Lausanne 1015, Switzerland.
authors.forename: Aaron J
authors.initials: AJ
authors.lastname: Rossini
authors.affiliation: Ecole Polytechnique Fédérale de Lausanne, Institut des Sciences et Ingénierie Chimiques, Lausanne 1015, Switzerland.
authors.forename: Lyndon
authors.initials: L
authors.lastname: Emsley
authors.affiliation: Ecole Polytechnique Fédérale de Lausanne, Institut des Sciences et Ingénierie Chimiques, Lausanne 1015, Switzerland.|Département de Chimie, Ecole Normale Supérieure, PSL Research University, UPMC Univ Paris 06, CNRS, Laboratoire des Biomolécules (LBM), 24 Rue Lhomond, 75005 Paris, France.|Sorbonne Universités, UPMC Paris 06, Ecole Normale Supérieure, CNRS, Laboratoire des Biomolécules (LBM), Paris, France.
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Bodenhausen
authors.affiliation: Ecole Polytechnique Fédérale de Lausanne, Institut des Sciences et Ingénierie Chimiques, Lausanne 1015, Switzerland.|Univ Lyon, CNRS, Université Claude Bernard Lyon 1, ENS de Lyon, Institut des Sciences Analytiques, UMR 5280, 5 rue de la Doua, 69100 Villeurbanne, France.
authors.forename: Sami
authors.identifier: 0000-0002-8877-4929
authors.initials: S
authors.lastname: Jannin
mesh_terms: D000409:Alanine / Q000737:chemistry; D002247:Carbon Isotopes / Q000737:chemistry; D003497:Cyclic N-Oxides / Q000737:chemistry; D005998:Glycine / Q000737:chemistry; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D055432:Metabolomics / Q000379:methods*; D013048:Specimen Handling / Q000295:instrumentation / Q000379:methods*; D013113:Spin Labels
chemical_list: D002247:Carbon Isotopes; D003497:Cyclic N-Oxides; D013113:Spin Labels; D000409:Alanine; D005998:Glycine; C001803:tempol