title: Susceptibility of Overweight Mice to Liver Injury as a Result of the ZnO Nanoparticle-Enhanced Liver Deposition of Pb2.
abstract: The prevalence of the applications of nanomaterials in consumer products and water treatment facilities increases the chance that humans will be exposed to both nanoparticles and environmental pollutants such as heavy metals. Co-exposure to nanoparticles and heavy metals may adversely affect human health, especially in susceptible populations such as overweight subjects. To evaluate the impact of such co-exposures, we orally administered zinc oxide nanoparticles (ZNPs; 14 or 58 nm) and/or Pb(Ac)2at tolerable doses to both healthy overweight and healthy normal weight mice. The ZNPs enhanced the deposition of Pb in all major organs in the overweight mice compared with that in the normal mice. As a result, higher levels of hepatic reactive oxygen species, pro-inflammatory cytokines, and liver injury were observed in the overweight mice but not in the normal weight mice. Our findings underscore a potentially enhanced risk of nanoparticle/heavy metal co-exposure in the susceptible overweight population.
authors.affiliation: School of Chemistry and Chemical Engineering, Shandong University , Jinan 250100, P. R. China.
authors.forename: Jianbo
authors.initials: J
authors.lastname: Jia
authors.affiliation: School of Chemistry and Chemical Engineering, Shandong University , Jinan 250100, P. R. China.
authors.forename: Feifei
authors.initials: F
authors.lastname: Li
authors.affiliation: School of Chemistry and Chemical Engineering, Shandong University , Jinan 250100, P. R. China.
authors.forename: Shumei
authors.initials: S
authors.lastname: Zhai
authors.affiliation: School of Environment, Jinan University , Guangzhou 510632, P. R. China.
authors.forename: Hongyu
authors.initials: H
authors.lastname: Zhou
authors.affiliation: State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences , Beijing 100085, P. R. China.
authors.forename: Sijin
authors.initials: S
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences , Beijing 100085, P. R. China.
authors.forename: Guibin
authors.initials: G
authors.lastname: Jiang
authors.affiliation: School of Chemistry and Chemical Engineering, Shandong University , Jinan 250100, P. R. China.|School of Environment, Jinan University , Guangzhou 510632, P. R. China.
authors.forename: Bing
authors.identifier: 0000-0002-7970-6764
authors.initials: B
authors.lastname: Yan
mesh_terms: D000818:Animals; D006801:Humans; D007854:Lead; D008099:Liver; D019216:Metals, Heavy; D051379:Mice; D053758:Nanoparticles; D050177:Overweight; D015034:Zinc Oxide
chemical_list: D019216:Metals, Heavy; D007854:Lead; D015034:Zinc Oxide