title: The progress and challenges for dermal regeneration in tissue engineering.
abstract: Wound healing is an inherent response resulting in the restoration of tissue integrity. It is a complex process involving cell migration, proliferation, differentiation, apoptosis, and the synthesis and remodeling of the extracellular matrix (ECM). The dermal tissue is an important component of skin that acts as a connecting link between the epidermis and hypodermis. The appearance of scars and contractures after autologous split-thickness skin transplantation or single epidermis diaphragm transplantation for full skin defects indicates that the dermal tissue plays an important role in skin regeneration. Theoretically, dermis cannot regenerate like the liver, bone and epidermis after being destroyed by burns or avulsion. Scarring is hard to avoid during the process of natural healing. However, if the dermis could be reconstructed perfectly, this would be a breakthrough in the methods used for wound healing. In this review, we summarize recent research about dermal regeneration and discuss the probability of advances in the field. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 1208-1218, 2017.
authors.affiliation: Department of Burns, 2nd Affiliated Hospital of Zhejiang University, College of Medicine, Hangzhou, 310009, China.
authors.forename: Hanlei
authors.initials: H
authors.lastname: Zhou
authors.affiliation: Department of Burns, 2nd Affiliated Hospital of Zhejiang University, College of Medicine, Hangzhou, 310009, China.
authors.forename: Chuangang
authors.initials: C
authors.lastname: You
authors.affiliation: Department of Burns, 2nd Affiliated Hospital of Zhejiang University, College of Medicine, Hangzhou, 310009, China.
authors.forename: Xingang
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Burns, 2nd Affiliated Hospital of Zhejiang University, College of Medicine, Hangzhou, 310009, China.
authors.forename: Ronghua
authors.initials: R
authors.lastname: Jin
authors.affiliation: Department of Burns, 2nd Affiliated Hospital of Zhejiang University, College of Medicine, Hangzhou, 310009, China.
authors.forename: Pan
authors.initials: P
authors.lastname: Wu
authors.affiliation: Department of Burns, 2nd Affiliated Hospital of Zhejiang University, College of Medicine, Hangzhou, 310009, China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Burns, 2nd Affiliated Hospital of Zhejiang University, College of Medicine, Hangzhou, 310009, China.
authors.forename: Chunmao
authors.initials: C
authors.lastname: Han
mesh_terms: D000818:Animals; D004817:Epidermis / Q000502:physiology*; D006801:Humans; D012038:Regeneration; D023822:Tissue Engineering / Q000379:methods*
keywords: artificial dermis; dermal regeneration; stem cells; wound healing