title: Subfoveal Choroidal Thickness in Central Serous Chorioretinopathy: A Meta-Analysis.
abstract: OBJECTIVE
  To evaluate the relationship between subfoveal choroidal thickness (SFCT) and eyes with central serous chorioretinopathy (CSC) versus fellow or control eyes.
  
  
  METHODS
  We performed a meta-analysis using databases including PubMed, Embase and ISI Web of Science to find relevant studies. Weighted mean difference (WMD) was calculated for the SFCT in CSC eyes, the unaffected fellow eyes and normal controls.
  
  
  RESULTS
  Twelve studies were selected for this meta-analysis, including 1108 eyes (397 CSC eyes, 228 unaffected fellow eyes and 483 eyes of normal controls). The meta-analysis clearly demonstrated that the subfoveal choiroid of eyes with a clinical presentation of CSC was thickened compared to unaffected fellow eyes (WMD = 52.81, 95% confidence interval (CI), 39.13-66.49, P<0.00001) and was thickened compared to control eyes (WMD = 145.03, 95%CI, 121.33-168.73, P<0.00001). The mean SFCT measurement of the unaffected fellow eyes showed also significantly increased choroidal thickness compared to that of normal control eyes (WMD = 77.20, 95% CI, 44.98-109.42, P<0.00001). Similar results were obtained in a sub-analysis based on the same instrument.
  
  
  CONCLUSIONS
  It is demonstrated that SFCT is significantly increased in eyes with clinical manifestation of CSC, and in the clinically non-manifested fellow eyes. These results support the hypothesis that CSC is a bilateral disorder with an initial unilateral clinical presentation.
authors.affiliation: Department of Ophthalmology, Quzhou People's Hospital, Quzhou, Zhejiang, PR China.
authors.forename: Guohai
authors.initials: G
authors.lastname: Chen
authors.affiliation: Department of Ophthalmology, University of South Florida, Tampa, Florida, United States of America.|The Roskamp Institute, Sarasota, Florida, United States of America.
authors.forename: Radouil
authors.initials: R
authors.lastname: Tzekov
authors.affiliation: Xiamen Eye Center of Xiamen University, Xiamen, Fujian, PR China.
authors.forename: Wensheng
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Ophthalmology, Quzhou People's Hospital, Quzhou, Zhejiang, PR China.
authors.forename: Fangzheng
authors.initials: F
authors.lastname: Jiang
authors.affiliation: Department of Ophthalmology, Quzhou People's Hospital, Quzhou, Zhejiang, PR China.
authors.forename: Sihong
authors.initials: S
authors.lastname: Mao
authors.affiliation: Department of Ophthalmology, Quzhou People's Hospital, Quzhou, Zhejiang, PR China.
authors.forename: Yuhua
authors.initials: Y
authors.lastname: Tong
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D056833:Central Serous Chorioretinopathy / Q000175:diagnosis / Q000473:pathology*; D002829:Choroid / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D041623:Tomography, Optical Coherence; D014792:Visual Acuity