title: Bottom-up fabrication of zwitterionic polymer brushes on intraocular lens for improved biocompatibility.
abstract: Intraocular lens (IOL) is an efficient implantable device commonly used for treating cataracts. However, bioadhesion of bacteria or residual lens epithelial cells on the IOL surface after surgery causes postoperative complications, such as endophthalmitis or posterior capsular opacification, and leads to loss of sight again. In the present study, zwitterionic polymer brushes were fabricated on the IOL surface via bottom-up grafting procedure. The attenuated total reflection-Fourier transform infrared and contact angle measurements indicated successful surface modification, as well as excellent hydrophilicity. The coating of hydrophilic zwitterionic polymer effectively decreased the bioadhesion of lens epithelial cells or bacteria. In vivo intraocular implantation results showed good in vivo biocompatibility of zwitterionic IOL and its effectiveness against postoperative complications.
authors.affiliation: School of Ophthalmology & Optometry, Eye Hospital, Wenzhou Medical University.
authors.forename: Yuemei
authors.initials: Y
authors.lastname: Han
authors.affiliation: School of Ophthalmology & Optometry, Eye Hospital, Wenzhou Medical University.
authors.forename: Xu
authors.initials: X
authors.lastname: Xu
authors.affiliation: School of Ophthalmology & Optometry, Eye Hospital, Wenzhou Medical University.
authors.forename: Junmei
authors.initials: J
authors.lastname: Tang
authors.affiliation: Wenzhou Institute of Biomaterials and Engineering, Chinese Academy of Sciences, Wenzhou, People's Republic of China.
authors.forename: Chenghui
authors.initials: C
authors.lastname: Shen
authors.affiliation: School of Ophthalmology & Optometry, Eye Hospital, Wenzhou Medical University; Wenzhou Institute of Biomaterials and Engineering, Chinese Academy of Sciences, Wenzhou, People's Republic of China.
authors.forename: Quankui
authors.initials: Q
authors.lastname: Lin
authors.affiliation: School of Ophthalmology & Optometry, Eye Hospital, Wenzhou Medical University; Wenzhou Institute of Biomaterials and Engineering, Chinese Academy of Sciences, Wenzhou, People's Republic of China.
authors.forename: Hao
authors.initials: H
authors.lastname: Chen
mesh_terms: D000818:Animals; D001422:Bacterial Adhesion; D002386:Cataract / Q000628:therapy*; D004847:Epithelial Cells; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D007903:Lens Capsule, Crystalline / Q000187:drug effects*; D019654:Lens Implantation, Intraocular / Q000379:methods*; D007908:Lens, Crystalline / Q000187:drug effects; D007910:Lenses, Intraocular; D018625:Microscopy, Atomic Force; D018918:Phacoemulsification; D011108:Polymers / Q000737:chemistry*; D011183:Postoperative Complications; D011474:Prosthesis Design; D011817:Rabbits; D013499:Surface Properties
chemical_list: D011108:Polymers
keywords: PCO; RAFT; endophthalmitis; in vivo; surface modification