title: Five Near Full-Length Hepatitis C Virus Sequences Were Identified from HIV Coinfected Injection Drug Users of China.
abstract: HIV and hepatitis C virus (HCV) share transmission routes, including contaminated blood transfusion, sexual intercourse, and needle-sharing in injection drug users (IDUs). We obtained five near full-length genome sequences of HCV isolated from five HIV-1-coinfected IDUs in Sichuan and Xinjiang provinces, China. By conducting reconstruction of neighbor-joining phylogenetic tree, our results revealed that the five isolates are of four different genotypes (1b, 3a, 6a, and 6n). The amino acid substitutions (170I) in XJN0021 related to resistant to protease inhibitors (grazoprevir) were also identified. The genetic diversity of these sequences uncovered more complicated transmission situation of HCV among IDUs in China.
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention , Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing, China .
authors.forename: Fan
authors.initials: F
authors.lastname: Li
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention , Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing, China .
authors.forename: Yi
authors.initials: Y
authors.lastname: Feng
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention , Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing, China .
authors.forename: Na
authors.initials: N
authors.lastname: Ni
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention , Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing, China .
authors.forename: Jing
authors.initials: J
authors.lastname: Hu
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention , Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing, China .
authors.forename: Yuhua
authors.initials: Y
authors.lastname: Ruan
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention , Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing, China .
authors.forename: Yiming
authors.initials: Y
authors.lastname: Shao
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention , Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing, China .
authors.forename: Liying
authors.initials: L
authors.lastname: Ma
mesh_terms: D019943:Amino Acid Substitution; D002681:China; D018562:Disease Transmission, Infectious; D024882:Drug Resistance, Viral; D005260:Female; D016679:Genome, Viral; D005838:Genotype; D015658:HIV Infections / Q000150:complications*; D016174:Hepacivirus / Q000235:genetics* / Q000302:isolation & purification*; D019698:Hepatitis C, Chronic / Q000635:transmission / Q000821:virology*; D006518:Hepatitis Viruses; D006801:Humans; D008297:Male; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D017385:Sequence Homology; D015819:Substance Abuse, Intravenous / Q000150:complications*
chemical_list: D012367:RNA, Viral
keywords: IDUs; diversity; hepatitis C virus; near full-length genome