title: Localization of muscarinic acetylcholine receptor 2 to the intestinal crypt stem cell compartment.
abstract: The data presented in this article are related to the research article entitled "Distribution of muscarinic acetylcholine receptor subtypes in the murine small intestine" (E.D. Muise, N. Gandotra, J.J. Tackett, M.C. Bamdad, R.A. Cowles, 2016) [1]. We recently demonstrated that neuronal serotonin stimulates intestinal crypt cell division, and induces villus growth and crypt depth (E.R. Gross, M.D. Gershon, K.G. Margolis, Z.V. Gertsberg, Z. Li, R.A. Cowles, 2012; M.D. Gershon, 2013) [2], [3]. Scopolamine, a nonspecific muscarinic receptor antagonist, inhibited serotonin-induced intestinal mucosal growth [2]. Here we provide data regarding the localization of muscarinic acetylcholine receptor 2 to the intestinal crypt stem cell compartment.
authors.affiliation: Department of Surgery, Section of Pediatric Surgery, Yale School of Medicine, USA.
authors.forename: Eleanor D
authors.initials: ED
authors.lastname: Muise
authors.affiliation: Department of Surgery, Section of Pediatric Surgery, Yale School of Medicine, USA.
authors.forename: Neeru
authors.initials: N
authors.lastname: Gandotra
authors.affiliation: Department of Surgery, Section of Pediatric Surgery, Yale School of Medicine, USA.
authors.forename: John J
authors.initials: JJ
authors.lastname: Tackett
authors.affiliation: Department of Surgery, Section of Pediatric Surgery, Yale School of Medicine, USA.
authors.forename: Michaela C
authors.initials: MC
authors.lastname: Bamdad
authors.affiliation: Department of Surgery, Section of Pediatric Surgery, Yale School of Medicine, USA.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Cowles
keywords: Enteric nervous system; Intestinal crypt; Muscarinic acetylcholine receptor; Paneth cell; Stem cell compartment