title: Pain Analysis in Patients with Pancreatic Carcinoma: Irreversible Electroporation versus Cryoablation.
abstract: The aim of this article is to evaluate and compare the postprocedure pain in patients with pancreatic carcinoma treated with irreversible electroporation (IRE) and cryoablation (CRYO). We compared 22 patients with 22 lesions in pancreas treated with IRE and 26 patients with 27 lesions treated with cryosurgery. All the patients in the two groups were under celiac plexus block (CPB) treatment to alleviate the postprocedure pain. A numerical rating scale (VAS) consisting of 11-point scales and the 24 h total hydromorphone use were recorded for the analysis of the pain level in the patients who underwent these two technologies separately. Other parameters, such as the complications and the ECOG performance status, were also noted. Statistical analysis was performed by Fisher's exact test, the Chi-square test, and Student'st-test. All the pancreatic carcinoma patients in our study were reported to have postprocedure pain in the two groups. But there was no significant difference in the mean pain score (4.95 (IRE) versus 4.85 (CRYO);P= 0.52) and 24 h total hydromorphone use (3.89 mg (IRE) versus 3.97 mg (CRYO);P= 0.30). IRE is comparable to cryotherapy in the amount of pain that patients with pancreatic carcinoma experience.
authors.affiliation: Department of General Surgery, The Second Hospital of Jilin University, Changchun, Jilin, China.
authors.forename: Jiannan
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Gastrointestinal Colorectal and Anal Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.
authors.forename: Shihou
authors.initials: S
authors.lastname: Sheng
authors.affiliation: Department of General Surgery, The Second Hospital of Jilin University, Changchun, Jilin, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Zhang
authors.affiliation: Department of General Surgery, The Second Hospital of Jilin University, Changchun, Jilin, China.
authors.forename: Tongjun
authors.identifier: 0000-0003-1838-8800
authors.initials: T
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D003452:Cryosurgery; D053672:Electrochemotherapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010149:Postoperative Pain / Q000503:physiopathology*; D010190:Pancreatic Neoplasms / Q000503:physiopathology* / Q000628:therapy*