title: microRNAs Expression as Novel Genetic Biomarker for Early Prediction and Continuous Monitoring in Pulmonary Cancer.
abstract: One of the main causes of death in the world is lung cancer. According to the World Health Organization, the annual incidence of lung cancer increases significantly. Moreover, lung cancer accounts for one of the highest mortality rates, mainly due to late detection. Numerous studies have been conducted in order to identify new biomarkers for early diagnosis and for monitoring and evaluation of lung cancer stages. An ideal biomarker candidate is represented by the analysis of microRNAs expression. In this paper, we want to summarize microRNAs expressions in lung cancer. We also want to present the expression of microRNAs depending on the evolution of lung cancer. For this study, we analyzed the studies available in scientific databases, such as PubMed and Scopus. The studies were selected using the search keywords "microRNAs expression," "lung cancer," and "genetic biomarkers." The most significant articles were selected for the study, following rigorous analysis. To evaluate and monitor lung cancer, the expression of microRNAs may be used successfully due to increased specificity and selectivity. However, further studies are needed on the assignment and validation of microRNAs for each type of lung cancer, respectively, for each stage of evolution.
authors.affiliation: Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
authors.forename: Razvan
authors.initials: R
authors.lastname: Nitu
authors.affiliation: Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania. alexandru.rogobete@umft.ro.|Clinic of Anesthesia and Intensive Care, Emergency County Hospital "Pius Brinzeu", Timisoara, Romania. alexandru.rogobete@umft.ro.
authors.forename: Alexandru Florin
authors.identifier: http://orcid.org/0000-0003-1286-4431
authors.initials: AF
authors.lastname: Rogobete
authors.affiliation: Faculty of Medicine, Ataturk University, Erzurum, Turkey.
authors.forename: Fuat
authors.initials: F
authors.lastname: Gundogdu
authors.affiliation: Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
authors.forename: Sonia
authors.initials: S
authors.lastname: Tanasescu
authors.affiliation: Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
authors.forename: Ovidiu
authors.initials: O
authors.lastname: Boruga
authors.affiliation: Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
authors.forename: Adriana
authors.initials: A
authors.lastname: Sas
authors.affiliation: Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
authors.forename: Sonia Elena
authors.initials: SE
authors.lastname: Popovici
authors.affiliation: Faculty of Chemistry, Biology Geography, West University of Medicine and Pharmacy, Timisoara, Romania.
authors.forename: Delia
authors.initials: D
authors.lastname: Hutanu
authors.affiliation: Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
authors.forename: Ciprian
authors.initials: C
authors.lastname: Pilut
authors.affiliation: Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
authors.forename: Cristian Andrei
authors.initials: CA
authors.lastname: Sarau
authors.affiliation: Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
authors.forename: Adrian Constantin
authors.initials: AC
authors.lastname: Candea
authors.affiliation: Faculty of Dental Medicine, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
authors.forename: Adrian Tudor
authors.initials: AT
authors.lastname: Stan
authors.affiliation: Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
authors.forename: Liviu Marius
authors.initials: LM
authors.lastname: Moise
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics*; D055088:Early Detection of Cancer; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D035683:MicroRNAs / Q000235:genetics*
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs
keywords: Cancer; Epigenetic biomarkers; Genetic biomarkers; Lung cancer; Non-small cell lung cancer; Small cell lung cancer; microRNAs