title: A Live Attenuated Chimeric West Nile Virus Vaccine, rWN/DEN4Δ30, Is Well Tolerated and Immunogenic in Flavivirus-Naive Older Adult Volunteers.
abstract: West Nile virus (WNV) is a major cause of mosquito-borne illness in the United States. Human disease ranges from mild febrile illness to severe fatal neurologic infection. Adults aged >60 years are more susceptible to neuroinvasive disease accompanied by a high mortality rate or long-lasting neurologic sequelae. A chimeric live attenuated West Nile virus vaccine, rWN/DEN4Δ30, was shown to be safe and immunogenic in healthy adults aged 18-50 years. This study evaluated rWN/DEN4Δ30 in flavivirus-naive adults aged 50-65 years and found it to be safe and immunogenic. Outbreaks of WNV infection tend to be unpredictable, and a safe and effective vaccine will be an important public health tool.
authors.affiliation: Robert Larner MD College of Medicine at the University of Vermont, Burlington.
authors.forename: Kristen K
authors.initials: KK
authors.lastname: Pierce
authors.affiliation: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda.
authors.forename: Stephen S
authors.initials: SS
authors.lastname: Whitehead
authors.affiliation: Robert Larner MD College of Medicine at the University of Vermont, Burlington.
authors.forename: Beth D
authors.initials: BD
authors.lastname: Kirkpatrick
authors.affiliation: Center for Immunization Research, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
authors.forename: Palmtama L
authors.initials: PL
authors.lastname: Grier
authors.affiliation: Robert Larner MD College of Medicine at the University of Vermont, Burlington.
authors.forename: Adrienne
authors.initials: A
authors.lastname: Jarvis
authors.affiliation: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda.
authors.forename: Heather
authors.initials: H
authors.lastname: Kenney
authors.affiliation: Robert Larner MD College of Medicine at the University of Vermont, Burlington.
authors.forename: Marya P
authors.initials: MP
authors.lastname: Carmolli
authors.affiliation: Robert Larner MD College of Medicine at the University of Vermont, Burlington.
authors.forename: Cynthia
authors.initials: C
authors.lastname: Reynolds
authors.affiliation: Center for Immunization Research, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
authors.forename: Cecilia M
authors.initials: CM
authors.lastname: Tibery
authors.affiliation: Center for Immunization Research, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
authors.forename: Janece
authors.initials: J
authors.lastname: Lovchik
authors.affiliation: Center for Immunization Research, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
authors.forename: Anna
authors.initials: A
authors.lastname: Janiak
authors.affiliation: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda.
authors.forename: Catherine J
authors.initials: CJ
authors.lastname: Luke
authors.affiliation: Center for Immunization Research, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
authors.forename: Anna P
authors.initials: AP
authors.lastname: Durbin
authors.affiliation: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda.
authors.forename: Alexander G
authors.initials: AG
authors.lastname: Pletnev
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D057134:Antibodies, Neutralizing / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood; D004196:Disease Outbreaks; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000069078:Seroconversion; D014481:United States; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology; D014766:Viremia; D014901:West Nile Fever / Q000453:epidemiology; D053060:West Nile Virus Vaccines / Q000008:administration & dosage / Q000009:adverse effects* / Q000235:genetics / Q000276:immunology*; D014902:West Nile virus / Q000276:immunology
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D014613:Vaccines, Attenuated; D053060:West Nile Virus Vaccines
keywords: West Nile virus; flavivirus; vaccine