title: PRKCD/PKCδ contributes to nephrotoxicity during cisplatin chemotherapy by suppressing autophagy.
abstract: Nephrotoxicity is a major side effect during chemotherapy with cisplatin and related platinum compounds. Previous work unveiled a role of PRKCD/PKCδ (protein kinase C delta) in cisplatin-induced nephrotoxicity; however, the underlying mechanism was largely unknown. Our recent work showed that PRKCD may suppress macroautophagy/autophagy, a cytoprotective mechanism, to promote kidney tubule cell death during cisplatin treatment. Interestingly, PRKCD may do so by phosphorylating AKT, which further phosphorylates MTOR to repress ULK1.
authors.affiliation: a Department of Emergency Medicine , The Second Xiangya Hospital, Central South University , Changsha , Hunan , China.|b Department of Cellular Biology and Anatomy , Medical College of Georgia at Augusta University and Charlie Norwood VA Medical Center , Augusta , GA , USA.
authors.forename: Dongshan
authors.initials: D
authors.lastname: Zhang
authors.affiliation: a Department of Emergency Medicine , The Second Xiangya Hospital, Central South University , Changsha , Hunan , China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Xu
authors.affiliation: b Department of Cellular Biology and Anatomy , Medical College of Georgia at Augusta University and Charlie Norwood VA Medical Center , Augusta , GA , USA.|c Department of Nephrology , The Second Xiangya Hospital, Central South University , Changsha , Hunan , China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Dong
mesh_terms: D000818:Animals; D001343:Autophagy / Q000187:drug effects*; D002945:Cisplatin / Q000009:adverse effects*; D006801:Humans; D007668:Kidney / Q000201:enzymology* / Q000473:pathology*; D008954:Models, Biological; D051745:Protein Kinase C-delta / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D051745:Protein Kinase C-delta; D002945:Cisplatin
keywords: AKT; MTOR; PKCδ; autophagy; chemotherapy; cisplatin; kidney; nephrotoxicity; side effect