title: INFANTS WITH CONGENITAL ZIKA SYNDROME AND OCULAR FINDINGS FROM SÃO PAULO, BRAZIL: SPREAD OF INFECTION.
abstract: OBJECTIVE
  To describe the ocular findings of two infants with congenital Zika syndrome born in São Paulo state, Brazil, outside the primary outbreak region.
  
  
  METHODS
  Two female infants with congenital Zika syndrome were submitted to a complete screening for infectious diseases, as well as ocular examination, fundus photography, and optical coherence tomography of the retina. One of the infants was submitted to ocular ultrasound.
  
  
  RESULTS
  Both children showed positive serology for Zika virus, and other infectious diseases were ruled out. On fundus examination, one newborn had extensive bilateral macular chorioretinal atrophy with hyperpigmented borders associated with gross pigment mottling, as well as atrophic well-limited roundish peripheral lesions in the right eye. Spectral domain optical coherence tomography of the right eye showed complete chorioretinal atrophy in the temporal quadrant. The other infant presented bilateral gross pigment mottling in a paramacular location and a normal optical coherence tomography.
  
  
  CONCLUSIONS
  In this report, the ophthalmologic findings of two infants with Zika syndrome and ocular findings born in São Paulo state, Brazil, are described. Optical coherence tomography findings demonstrate the broad range of retinal damage caused by congenital Zika virus infection.
  
  
  CONCLUSIONS
  The autochthonous cases of infants with congenital Zika syndrome and ocular findings described in this report demonstrate that Zika virus infection is not limited to northeast Brazil, with the potential for even greater spread.
authors.affiliation: Department of Ophthalmology, Federal University of São Paulo, Paulista Medical School, São Paulo, Brazil.
authors.forename: João Rafael
authors.initials: JR
authors.lastname: de Oliveira Dias
authors.affiliation: Department of Ophthalmology, Federal University of São Paulo, Paulista Medical School, São Paulo, Brazil.|Department of Ophthalmology, Altino Ventura Foundation, Recife, Brazil.
authors.forename: Camila V
authors.initials: CV
authors.lastname: Ventura
authors.affiliation: Department of Ophthalmology, Federal University of São Paulo, Paulista Medical School, São Paulo, Brazil.
authors.forename: Paula Delegrego
authors.initials: PD
authors.lastname: Borba
authors.affiliation: Department of Ophthalmology, Federal University of São Paulo, Paulista Medical School, São Paulo, Brazil.|Department of Ophthalmology, Roberto Santos General Hospital, Salvador, Brazil.
authors.forename: Bruno
authors.initials: B
authors.lastname: de Paula Freitas
authors.affiliation: Clinical Research Center, DASA Diagnostic Medicine, São Paulo, Brazil.
authors.forename: Ligia Camera
authors.initials: LC
authors.lastname: Pierroti
authors.affiliation: Clinical Research Center, DASA Diagnostic Medicine, São Paulo, Brazil.
authors.forename: Ana Patricia
authors.initials: AP
authors.lastname: do Nascimento
authors.affiliation: Department of Ophthalmology, Federal University of São Paulo, Paulista Medical School, São Paulo, Brazil.
authors.forename: Nilva Simeren Bueno
authors.initials: NSB
authors.lastname: de Moraes
authors.affiliation: Department of Ophthalmology, Federal University of São Paulo, Paulista Medical School, São Paulo, Brazil.
authors.forename: Maurício
authors.initials: M
authors.lastname: Maia
authors.affiliation: Department of Ophthalmology, Federal University of São Paulo, Paulista Medical School, São Paulo, Brazil.
authors.forename: Rubens
authors.initials: R
authors.lastname: Belfort
mesh_terms: D015828:Eye Infections, Viral / Q000821:virology*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis*; D012164:Retinal Diseases / Q000821:virology*; D000071243:Zika Virus Infection / Q000175:diagnosis*