title: Ovarian tumors in children: 10-year experience from a tertiary care center in South India.
abstract: BACKGROUND
  Ovarian tumors are uncommon in childhood and constitute around 1% of childhood malignancies. Two thirds of pediatric ovarian tumors are germ cell tumors. Epithelial ovarian tumors and stromal tumors are less frequent. We share our experience in childhood ovarian cancers, analyzing a series of cases with respect to the clinical profile, treatment and survival.
  
  
  METHODS
  All newly diagnosed ovarian tumors in children up to 14 years of age, registered in our Pediatric Oncology Division between January 2000 and December 2009 were retrospectively reviewed.
  
  
  METHODS
  There were 47 patients with newly diagnosed ovarian tumors. The mean age at presentation was 10.0 ± 3.4 years. The most common symptoms at presentation were acute abdominal pain (48.9%) and abdominal mass (40.4%). Precocious puberty was uncommon (6.3%). Histology was germ cell tumors in 44 cases and nongerm cell tumors in three cases. The benign teratomas (mature and immature grade 1 and 2; n=9) underwent complete surgical resection alone; none had recurrence on follow up. Of the remaining 35 GCTs, 31 patients were given chemotherapy and 4 refused treatment.26 out of the 31 patients completed chemotherapy with BEP (bleomycin, etoposide, cisplatin) regimen with acceptable toxicities. 5 children i.e.; (19.2%) developed recurrence. At a median follow up of 80 months, 10 year disease free survival was 80.8 ± 7.7% and 10 year overall survival was 92.7 ± 4.9%.
  
  
  CONCLUSIONS
  Germ cell tumors are the most common ovarian malignancy in children. With surgery and chemotherapy using BEP, good outcome can be expected in these patients.
authors.affiliation: Division of Pediatric Oncology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India.
authors.forename: B
authors.initials: B
authors.lastname: Rajeswari
authors.affiliation: Division of Pediatric Oncology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India.
authors.forename: M
authors.initials: M
authors.lastname: Nair
authors.affiliation: Division of Pediatric Oncology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India.
authors.forename: A
authors.initials: A
authors.lastname: Ninan
authors.affiliation: Division of Pediatric Oncology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India.
authors.forename: K
authors.initials: K
authors.lastname: Parukuttyamma
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007194:India; D007223:Infant; D010051:Ovarian Neoplasms / Q000473:pathology; D062606:Tertiary Care Centers; D013997:Time Factors