title: Investigations on pharmacokinetics and biodistribution of polymeric and solid lipid nanoparticulate systems of atypical antipsychotic drug: effect of material used and surface modification.
abstract: The present study focuses on the effect of material used for the preparation of nanoparticulate (NP) systems and surface modification on the pharmacokinetics and biodistribution of atypical antipsychotic, olanzapine (OLN). NP carriers of OLN were prepared from two different materials such as polymer (polycaprolactone) and solid lipid (Glyceryl monostearate). These systems were further surface modified with surfactant, Polysorbate 80 and studied for pharmacokinetics-biodistribution in Wistar rats using in-house developed bioanalytical methods. The pharmacokinetics and biodistribution studies resulted in a modified and varied distribution of NP systems with higher area under curve (AUC) values along with prolonged residence time of OLN in the rat blood circulation. The distribution of OLN to the brain was significantly enhanced with surfactant surface-modified NP systems, followed by nonsurface-modified NP formulations as compared with pure OLN solution. Biodistribution study demonstrated a low uptake of obtained NP systems by kidney and heart, thereby decreasing the nephrotoxicity and adverse cardiovascular effects. By coating the NP with surfactant, uptake of macrophage was found to be reduced. Thus, our studies confirmed that the biodistribution OLN could be modified effectively by incorporating in NP drug delivery systems prepared from different materials and surface modifications. A judicious selection of materials used for the preparation of delivery carriers and surface modifications would help to design a most efficient drug delivery system with better therapeutic efficacy.
authors.affiliation: a Department of Pharmacy , Birla Institute of Technology and Science , Pilani , India.
authors.forename: Emil
authors.initials: E
authors.lastname: Joseph
authors.affiliation: a Department of Pharmacy , Birla Institute of Technology and Science , Pilani , India.
authors.forename: Ranendra N
authors.initials: RN
authors.lastname: Saha
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000737:chemistry* / Q000493:pharmacokinetics*; D001569:Benzodiazepines / Q000737:chemistry* / Q000493:pharmacokinetics*; D001921:Brain / Q000378:metabolism; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods; D005079:Excipients / Q000737:chemistry; D005989:Glycerides / Q000737:chemistry; D008055:Lipids / Q000737:chemistry*; D008297:Male; D053758:Nanoparticles / Q000737:chemistry*; D000077152:Olanzapine; D011091:Polyesters / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D011136:Polysorbates / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D013501:Surface-Active Agents / Q000737:chemistry; D014018:Tissue Distribution
chemical_list: D014150:Antipsychotic Agents; D004337:Drug Carriers; D005079:Excipients; D005989:Glycerides; D008055:Lipids; D011091:Polyesters; D011108:Polymers; D011136:Polysorbates; D013501:Surface-Active Agents; D001569:Benzodiazepines; C048159:glyceryl monostearate; C016240:polycaprolactone; D000077152:Olanzapine
keywords: Olanzapine; organ distribution; polymeric nanoparticles; solid lipid nanoparticles; surfactant coating