abstract: Recently, metastatic melanoma has known real therapeutic improvement. Since 2011, 8 drugs have been approved for advanced melanoma such as immunotherapy checkpoint inhibitors. Chemotherapy is no longer used in the first setting of metastatic melanoma treatment. In 2010, the advent of ipilimumab, an anti CTLA 4 inhibitor, changed the scenario and in the following years, many studies confirmed the efficacy of nivolumab and pembrolizumab, two anti PD 1 inhibitors, as a first line treatment. Furthermore, the combination of first-line nivolumab plus ipilimumab might lead to improved outcomes compared with first-line ipilimumab alone in patients with advanced melanoma. The results suggest encouraging survival outcomes with immunotherapy in this population of patients. However, the management of tumoral response and immune related toxicity, patient selection (what would be the most effective therapy for an individual patient?) are a real challenge.
authors.affiliation: Service de dermatologie, Hôpital saint Louis, 1 av Claude Vellefaux 75010 Paris, 0142385312. Electronic address: cecile.pages@aphp.fr.
authors.forename: Cécile
authors.initials: C
authors.lastname: Pagès
authors.affiliation: Service de dermatologie, Hôpital saint Louis, 1 av Claude Vellefaux 75010 Paris, 0142385312.
authors.forename: Barouyr
authors.initials: B
authors.lastname: Baroudjian
authors.affiliation: Service de dermatologie, Hôpital saint Louis, 1 av Claude Vellefaux 75010 Paris, 0142385312.
authors.forename: Celeste
authors.initials: C
authors.lastname: Lebbé
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood; D059447:Cell Cycle Checkpoints / Q000187:drug effects / Q000276:immunology; D006801:Humans; D007167:Immunotherapy / Q000379:methods* / Q000639:trends; D000074324:Ipilimumab; D008545:Melanoma / Q000276:immunology / Q000556:secondary / Q000628:therapy*; D000077594:Nivolumab
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents; D015415:Biomarkers; D000074324:Ipilimumab; D000077594:Nivolumab; C582435:pembrolizumab
keywords: Clinical trials; Essai clinique; Ipilimumab; Nivolumab; Pembrolizumab