title: Lung cancer and chronic obstructive pulmonary disease: From a clinical perspective.
abstract: Chronic obstructive pulmonary disease (COPD) and lung cancer are devastating pulmonary diseases that commonly coexist and present a number of clinical challenges. COPD confers a higher risk for lung cancer development, but available chemopreventive measures remain rudimentary. Current studies have shown a marked benefit of cancer screening in the COPD population, although challenges remain, including the common underdiagnosis of COPD. COPD-associated lung cancer presents distinct clinical features. Treatment for lung cancer coexisting with COPD is challenging as COPD may increase postoperative morbidities and decrease survival. In this review, we outline current progress in the understanding of the clinical association between COPD and lung cancer, and suggest possible cancer prevention strategies in this patient population.
authors.affiliation: Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Dai
authors.affiliation: Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Minnesota, United States of America.
authors.forename: Ping
authors.initials: P
authors.lastname: Yang
authors.affiliation: Department of Oncology, University of Sheffield Medical School, Sheffield, United Kingdom.
authors.forename: Angela
authors.initials: A
authors.lastname: Cox
authors.affiliation: Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Gening
authors.initials: G
authors.lastname: Jiang
mesh_terms: D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000473:pathology; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis* / Q000473:pathology
keywords: association; chronic obstructive pulmonary disease; lung cancer