title: Analysis of the factors affecting the evolution over time of subclinical hypothyroidism in children.
abstract: Aim of this commentary is to report the most recent views about natural history of subclinical hypothyroidism (SH) according to the different etiologies. In children with idiopathic SH the natural evolution is often favourable, with a high percentage of cases reverting to euthyroidism or remaining SH even after a prolonged follow-up. By contrast, the risk of a significant deterioration of thyroid status is distinctly higher in the SH children with Hashimoto's thyroiditis (HT). This risk is even higher in the cases with both HT-related SH and chromosomal abnormalities, such as Turner or Down's syndrome.
authors.affiliation: Department of Human Pathology of Adulthood and Childhood, University of Messina, via Consolare Valeria, 98125, Messina, Italy.
authors.forename: Mariella
authors.initials: M
authors.lastname: Valenzise
authors.affiliation: Department of Human Pathology of Adulthood and Childhood, University of Messina, via Consolare Valeria, 98125, Messina, Italy.
authors.forename: Tommaso
authors.initials: T
authors.lastname: Aversa
authors.affiliation: Department of Human Pathology of Adulthood and Childhood, University of Messina, via Consolare Valeria, 98125, Messina, Italy.
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Zirilli
authors.affiliation: Department of Human Pathology of Adulthood and Childhood, University of Messina, via Consolare Valeria, 98125, Messina, Italy.
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Salzano
authors.affiliation: Department of Human Pathology of Adulthood and Childhood, University of Messina, via Consolare Valeria, 98125, Messina, Italy.
authors.forename: Domenico
authors.initials: D
authors.lastname: Corica
authors.affiliation: Department of Human Pathology of Adulthood and Childhood, University of Messina, via Consolare Valeria, 98125, Messina, Italy.
authors.forename: Simona
authors.initials: S
authors.lastname: Santucci
authors.affiliation: Department of Human Pathology of Adulthood and Childhood, University of Messina, via Consolare Valeria, 98125, Messina, Italy. filippo.deluca@unime.it.
authors.forename: Filippo
authors.initials: F
authors.lastname: De Luca
mesh_terms: D000293:Adolescent; D002648:Child; D018450:Disease Progression; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000097:blood / Q000175:diagnosis*; D008297:Male; D013961:Thyroid Gland / Q000378:metabolism*; D013972:Thyrotropin / Q000097:blood*
chemical_list: D013972:Thyrotropin
keywords: Chromosomopathies; Down’s syndrome; Hashimoto’s thyroiditis; Thyroid function; Thyroid status; Turner syndrome