title: Predictive features for histology of gastric subepithelial lesions.
abstract: BACKGROUND
  - Gastric subepithelial lesion is a relatively common diagnosis after routine upper endoscopy. The diagnostic workup of an undetermined gastric subepithelial lesion should take into consideration clinical and endoscopic features.
  
  
  OBJECTIVE
  - We aimed to investigate the association between patients' characteristics, endoscopic and echographic features with the histologic diagnosis of the gastric subepithelial lesions.
  
  
  METHODS
  - This is a retrospective study with 55 patients, who were consecutively diagnosed with gastric subepithelial lesions, from October 2008 to August 2011. Patients' characteristics, endoscopic and echografic features of each gastric subepithelial lesion were analysed. Histologic diagnosis provided by EUS-guided fine needle aspiration or endoscopic/surgical resection was used as gold standard.
  
  
  RESULTS
  - The probability of gastrointestinal stromal tumors to be located in the cardia was low (4.5%), while for leiomyoma it was high (>95%). In addition, there was a higher risk of gastrointestinal stromal tumors in patients older than 57 years (OR 8.9; 95% CI), with lesions ≥21 mm (OR 7.15; 95% CI), located at 4th layer (OR 18.8; 95% CI), with positive Doppler sign (OR 9; 95% CI), and irregular outer border (OR 7.75; 95% CI).
  
  
  CONCLUSIONS
  - The location of gastric subepithelial lesions in the gastric cardia lowers the risk of gastrointestinal stromal tumors. While gastric subepithelial lesions occurring in elderly patients, located in the gastric body, with positive Doppler signal and irregular outer border increase the risk of gastrointestinal stromal tumors.
authors.affiliation: Departamento de Gastroenterologia, Faculdade de Medicina, Universidade de São Paulo, SP, Brasil.
authors.forename: Ricardo Teles
authors.initials: RT
authors.lastname: Schulz
authors.affiliation: Departamento de Estatística, Instituto de Matemática, Universidade Federal da Bahia (UFBA), Salvador, BA, Brasil.
authors.forename: Lizandra Castilho
authors.initials: LC
authors.lastname: Fabio
authors.affiliation: Departamento de Gastroenterologia, Faculdade de Medicina, Universidade de São Paulo, SP, Brasil.
authors.forename: Matheus Cavalcante
authors.initials: MC
authors.lastname: Franco
authors.affiliation: Departamento de Patologia, Faculdade de Medicina, Universidade de São Paulo, SP, Brasil.
authors.forename: Sheila A
authors.initials: SA
authors.lastname: Siqueira
authors.affiliation: Departamento de Gastroenterologia, Faculdade de Medicina, Universidade de São Paulo, SP, Brasil.
authors.forename: Paulo
authors.initials: P
authors.lastname: Sakai
authors.affiliation: Departamento de Gastroenterologia, Faculdade de Medicina, Universidade de São Paulo, SP, Brasil.
authors.forename: Fauze
authors.initials: F
authors.lastname: Maluf-Filho
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044963:Biopsy, Fine-Needle; D019160:Endosonography; D005260:Female; D005773:Gastroscopy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D013272:Stomach Diseases / Q000175:diagnosis* / Q000473:pathology; D013274:Stomach Neoplasms; D055815:Young Adult