title: Bio-nano interface: The impact of biological environment on nanomaterials and their delivery properties.
abstract: The past several decades have witnessed the rapid development of nanomedicine (NM) which integrates the advancement of various interdisciplinary areas of science, engineering, and medicine. While a few clinical successes of NM greatly change the landscape of disease diagnosis and treatment, there are several areas of NM remaining to be explored. One such area is the complicated interactions between the NM and biological environment post administration, and how such interaction affects the biological performance of NM. Here, we review the recent progresses on this topic and discuss the interaction of NM with microscopic biomolecules, cells, and the macroscopic in vivo environment. The complete profiling of the bio/nanomaterials interface and interaction should have profound impact on the optimization and de novo design of new NM with better in vivo performance.
authors.affiliation: Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 W Green Street, 61801, USA.
authors.forename: Kaimin
authors.initials: K
authors.lastname: Cai
authors.affiliation: Laboratory of Nano- and Translational Medicine, Lineberger Comprehensive Cancer Center, Carolina Center for Cancer Nanotechnology Excellence, University of North Carolina at Chapel Hill, Chapel Hill, 27599, USA; Department of Radiation Oncology, Lineberger Comprehensive Cancer Center, Carolina Center for Cancer Nanotechnology Excellence, University of North Carolina at Chapel Hill, Chapel Hill, 27599, USA.
authors.forename: Andrew Z
authors.initials: AZ
authors.lastname: Wang
authors.affiliation: Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, China. Electronic address: lcyin@suda.edu.cn.
authors.forename: Lichen
authors.initials: L
authors.lastname: Yin
authors.affiliation: Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 W Green Street, 61801, USA; Department of Bioengineering, University of Illinois at Urbana-Champaign, 1304 W Green Street, 61801, USA; Department of Chemistry, University of Illinois at Urbana-Champaign, 1304 W Green Street, 61801, USA; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, 1304 W Green Street, 61801, USA; Micro and Nanotechnology Laboratory, University of Illinois at Urbana-Champaign, 1304 W Green Street, 61801, USA; Institute of Genomic Biology, University of Illinois at Urbana-Champaign, 1304 W Green Street, 61801, USA; Materials Research Laboratory, University of Illinois at Urbana-Champaign, 1304 W Green Street, 61801, USA; Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, China. Electronic address: jianjunc@illinois.edu.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Cheng
mesh_terms: D000327:Adsorption; D000818:Animals; D002477:Cells / Q000187:drug effects; D004777:Environment; D006801:Humans; D049329:Nanostructures / Q000008:administration & dosage* / Q000737:chemistry
keywords: Cell-mediated delivery; Drug delivery; Intracellular delivery; Nanomedicine; Protein corona