title: Research Advances in the Mechanisms of Gastric Cancer Multidrug Resistance.
abstract: Gastric cancer is one of the most common human malignancies and the third cause of death from cancer in China and worldwide. Chemotherapy is still one of the major treatment options for advanced gastric cancer. However,the efficacy of chemotherapy for gastric cancer remains poor due to its insensitivity and the development of multidrug resistance (MDR). While many molecules and mechanisms have been found to be associated with the development of gastric cancer MDR,the specific mechanisms remains unclear. In our current article,we reviews the identification of MDR-related molecules and mechanisms,with an attempt to a better understand the specific mechanisms of gastric cancer MDR and thus provide new insights into the fight against gastric cancer MDR.
authors.affiliation: Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College,Beijing 100021,China.
authors.forename: Hao
authors.initials: H
authors.lastname: Huang
authors.affiliation: Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College,Beijing 100021,China.
authors.forename: Xing-Jiu
authors.initials: XJ
authors.lastname: Yang
authors.affiliation: Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College,Beijing 100021,China.
authors.forename: Ran
authors.initials: R
authors.lastname: Gao
mesh_terms: D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D006801:Humans; D013274:Stomach Neoplasms / Q000188:drug therapy*