title: Platelet subpopulation bearing leukocyte specific antigen and tissue factor.
abstract: Platelets bearing leukocyte antigen CD45 were identified in the blood of patients with myocardial infarction (MI) and healthy donors by flow cytofluorimetry. Part of these platelets contained tissue factor (TF)-primary initiator of blood clotting. The number of CD45+and CD45+/TF+platelets in MI patients at the first day was comparable with their level in healthy donors, but was increased at 8-12 days after MI onset. At that time in some patients the amount of CD45+and CD45+/TF+platelets reached 5-6 and 2-3% of their total number. It is assumed that CD45+/TF+platelets could be formed as a result of platelet interaction with leukocytes or leukocyte produced membrane microparticles.
authors.affiliation: Russian Cardiology Research and production Complex, Russian Ministry of Health, Moscow, Russia.
authors.forename: Z A
authors.initials: ZA
authors.lastname: Gabbasov
authors.affiliation: Russian Cardiology Research and production Complex, Russian Ministry of Health, Moscow, Russia.
authors.forename: O S
authors.initials: OS
authors.lastname: Saburova
authors.affiliation: Russian Cardiology Research and production Complex, Russian Ministry of Health, Moscow, Russia.
authors.forename: O A
authors.initials: OA
authors.lastname: Antonova
authors.affiliation: Russian Cardiology Research and production Complex, Russian Ministry of Health, Moscow, Russia.
authors.forename: N V
authors.initials: NV
authors.lastname: Golubeva
authors.affiliation: Russian Cardiology Research and production Complex, Russian Ministry of Health, Moscow, Russia.
authors.forename: S G
authors.initials: SG
authors.lastname: Khaspekova
authors.affiliation: Russian Cardiology Research and production Complex, Russian Ministry of Health, Moscow, Russia.
authors.forename: O N
authors.initials: ON
authors.lastname: Shustova
authors.affiliation: Russian Cardiology Research and production Complex, Russian Ministry of Health, Moscow, Russia.
authors.forename: I T
authors.initials: IT
authors.lastname: Zyuryaev
authors.affiliation: Russian Cardiology Research and production Complex, Russian Ministry of Health, Moscow, Russia.
authors.forename: M Ya
authors.initials: MY
authors.lastname: Ruda
authors.affiliation: Russian Cardiology Research and production Complex, Russian Ministry of Health, Moscow, Russia. avmazurov@list.ru.
authors.forename: A V
authors.initials: AV
authors.lastname: Mazurov
mesh_terms: D001792:Blood Platelets / Q000378:metabolism*; D055252:Cell-Derived Microparticles / Q000378:metabolism; D018450:Disease Progression; D005260:Female; D006801:Humans; D017493:Leukocyte Common Antigens / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*; D013925:Thromboplastin / Q000378:metabolism*; D013997:Time Factors
chemical_list: D013925:Thromboplastin; D017493:Leukocyte Common Antigens; C516769:PTPRC protein, human