title: Fibrous Dysplasia Mimicking Malignancy on 68Ga-DOTATATE PET/CT.
abstract: Fibrous dysplasia of the bone is a developmental benign skeletal disorder characterized by replacement of normal bone and normal bone marrow with abnormal fibro-osseous tissue. We report on a case of a biopsy-proven fibrous dysplasia lesion in the left temporal bone, with intensely increased activity (SUVmax, 56.7) on Ga-DOTATATE PET/CT. The presented data indicate cell surface overexpression of somatostatin receptors by fibrous dysplastic cells and highlight the need of cautious management of Ga-DOTATATE-avid bone lesions, which could mimic malignancy especially in patients with history of neuroendocrine tumors.
authors.affiliation: From the *Radiology and Imaging Sciences, Warren Grant Magnuson Clinical Center, †PET Department; Clinical Center, and ‡Endocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD; §Endocrine and Thoracic Surgery, University Hospitals of Geneva, Geneva, Switzerland; ∥Department of Radiology, Medical School, University of Crete, Greece; and ¶Center for Research in Computer Vision, Electrical and Computer Science Department, University of Central Florida, Orlando, FL.
authors.forename: Georgios Z
authors.initials: GZ
authors.lastname: Papadakis
authors.forename: Corina
authors.initials: C
authors.lastname: Millo
authors.forename: Samira M
authors.initials: SM
authors.lastname: Sadowski
authors.forename: Apostolos H
authors.initials: AH
authors.lastname: Karantanas
authors.forename: Ulas
authors.initials: U
authors.lastname: Bagci
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Patronas
mesh_terms: D000368:Aged; D003937:Diagnosis, Differential; D005357:Fibrous Dysplasia of Bone / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D018358:Neuroendocrine Tumors / Q000000981:diagnostic imaging*; D009942:Organometallic Compounds; D000072078:Positron Emission Tomography Computed Tomography; D019275:Radiopharmaceuticals
chemical_list: D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; C513399:gallium Ga 68 dotatate