title: KTCNlncDB-a first platform to investigate lncRNAs expressed in human keratoconus and non-keratoconus corneas.
abstract: Keratoconus (KTCN, OMIM 148300) is a degenerative eye disorder characterized by progressive stromal thinning that leads to a conical shape of the cornea, resulting in optical aberrations and even loss of visual function. The biochemical background of the disease is poorly understood, which motivated us to perform RNA-Seq experiment, aimed at better characterizing the KTCN transcriptome and identification of long non-coding RNAs (lncRNAs) that might be involved in KTCN etiology. The in silico functional studies based on predicted lncRNA:RNA base-pairings led us to recognition of a number of lncRNAs possibly regulating genes with known or plausible links to KTCN. The lncRNA sequences and data regarding their predicted functions in controlling the RNA processing and stability are available for browse, search and download in KTCNlncDB (http://rhesus.amu.edu.pl/KTCNlncDB/), the first online platform devoted to KTCN transcriptome.Database URL: http://rhesus.amu.edu.pl/KTCNlncDB/.
authors.affiliation: Department of Genetics and Pharmaceutical Microbiology, Poznan University of Medical Sciences, Poznan, Poland.|Department of Integrative Genomics, Institute of Antropology, Adam Mickiewicz University in Poznan, Poznan, Poland.
authors.forename: Michal W
authors.initials: MW
authors.lastname: Szczesniak
authors.affiliation: Department of Genetics and Pharmaceutical Microbiology, Poznan University of Medical Sciences, Poznan, Poland.|Department of Integrative Genomics, Institute of Antropology, Adam Mickiewicz University in Poznan, Poznan, Poland.
authors.forename: Michal
authors.initials: M
authors.lastname: Kabza
authors.affiliation: Department of Genetics and Pharmaceutical Microbiology, Poznan University of Medical Sciences, Poznan, Poland.|Institute of Human Genetics Polish Academy of Sciences, Poznan, Poland.
authors.forename: Justyna A
authors.initials: JA
authors.lastname: Karolak
authors.affiliation: Department of Medical Genetics, Medical University of Warsaw, Warsaw, Poland and.
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Rydzanicz
authors.affiliation: Department of Genetics and Pharmaceutical Microbiology, Poznan University of Medical Sciences, Poznan, Poland.|Institute of Human Genetics Polish Academy of Sciences, Poznan, Poland.
authors.forename: Dorota M
authors.initials: DM
authors.lastname: Nowak
authors.affiliation: Department of Genetics and Pharmaceutical Microbiology, Poznan University of Medical Sciences, Poznan, Poland.|Institute of Human Genetics Polish Academy of Sciences, Poznan, Poland.
authors.forename: Barbara
authors.initials: B
authors.lastname: Ginter-Matuszewska
authors.affiliation: Department of Ophthalmology, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Polakowski
authors.affiliation: Department of Medical Genetics, Medical University of Warsaw, Warsaw, Poland and.
authors.forename: Rafal
authors.initials: R
authors.lastname: Ploski
authors.affiliation: Department of Ophthalmology, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Jacek P
authors.initials: JP
authors.lastname: Szaflik
authors.affiliation: Department of Genetics and Pharmaceutical Microbiology, Poznan University of Medical Sciences, Poznan, Poland.|Institute of Human Genetics Polish Academy of Sciences, Poznan, Poland.
authors.forename: Marzena
authors.initials: M
authors.lastname: Gajecka
mesh_terms: D003198:Computer Simulation; D003315:Cornea / Q000378:metabolism*; D030541:Databases, Genetic; D005786:Gene Expression Regulation; D006801:Humans; D007640:Keratoconus / Q000235:genetics / Q000378:metabolism; D012323:RNA Processing, Post-Transcriptional; D020871:RNA Stability; D062085:RNA, Long Noncoding / Q000096:biosynthesis / Q000235:genetics
chemical_list: D062085:RNA, Long Noncoding