title: Theoretical Implications of a Pre-Erythrocytic Plasmodium vivax Vaccine for Preventing Relapses.
abstract: Preventing malaria infection through vaccination requires preventing every sporozoite inoculated by mosquito bite: a major challenge for Plasmodium falciparum. Plasmodium vivax sporozoites consist of tachysporozoites causing primary infection and bradysporozoites leading to relapses. We hypothesise that a candidate P. vivax vaccine with low efficacy against primary infection may substantially reduce transmission by preventing relapses.
authors.affiliation: MRC Centre for Outbreak Analysis & Modelling, Department of Infectious Disease Epidemiology, Imperial College London, UK; Division of Population Health & Immunity, Walter and Eliza Hall Institute, Melbourne, Australia. Electronic address: m.white08@imperial.ac.uk.
authors.forename: Michael
authors.initials: M
authors.lastname: White
authors.affiliation: Department of Parasites & Insect Vectors, Institut Pasteur, Paris, France.
authors.forename: Rogerio
authors.initials: R
authors.lastname: Amino
authors.affiliation: Division of Population Health & Immunity, Walter and Eliza Hall Institute, Melbourne, Australia; Department of Parasites & Insect Vectors, Institut Pasteur, Paris, France.
authors.forename: Ivo
authors.initials: I
authors.lastname: Mueller
mesh_terms: D008018:Life Cycle Stages / Q000276:immunology; D008288:Malaria / Q000517:prevention & control*; D017780:Malaria Vaccines / Q000276:immunology*; D016780:Malaria, Vivax / Q000276:immunology / Q000469:parasitology / Q000517:prevention & control*; D010963:Plasmodium falciparum / Q000276:immunology; D010966:Plasmodium vivax / Q000276:immunology; D012008:Recurrence
chemical_list: D017780:Malaria Vaccines
keywords: Plasmodium vivax; hypnozoite; malaria; relapse; vaccine