title: [Autoimmune diseases of the thyroid gland].
abstract: Autoimmune diseases of the thyroid gland are considered to be the most frequent cause of thyroid gland disorders. Autoimmune thyroid diseases consist of two subgroups: autoimmune thyroiditis (AIT) and Graves' disease. The AIT is the most common human autoimmune disease. Infiltration of the thyroid gland with cytotoxic T‑cells can lead to an initial thyrotoxicosis und during the course to hypothyroidism due to destruction of the thyroid gland. Substitution with Levothyroxine is indicated for manifest hypothyroidism and subclinical hypothyroidism with increased thyroid antibodies with the intention of normalizing the serum thyroid stimulating hormone (TSH). Graves' disease is characterized by the appearance of stimulating TSH receptor antibodies leading to hyperthyroidism. Endocrine ophthalmopathy may also occur. Ablative therapy with radioiodine therapy or thyroidectomy is administered to patients with Graves' disease without remission after at least 1 year of antithyroid drug therapy.
authors.affiliation: Funktionsbereich Spezielle Endokrinologie, Universitätsklinikum Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Deutschland. stephanie.allelein@med.uni-duesseldorf.de.
authors.forename: S
authors.initials: S
authors.lastname: Allelein
authors.affiliation: Klinik für Allgemeine Innere Medizin, Endokrinologie, Diabetologie und Infektiologie, Klinikum Bielefeld Mitte, Bielefeld, Deutschland.
authors.forename: J
authors.initials: J
authors.lastname: Feldkamp
authors.affiliation: Funktionsbereich Spezielle Endokrinologie, Universitätsklinikum Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Deutschland.
authors.forename: M
authors.initials: M
authors.lastname: Schott
mesh_terms: D003131:Combined Modality Therapy / Q000379:methods; D019317:Evidence-Based Medicine; D006111:Graves Disease / Q000175:diagnosis* / Q000628:therapy*; D020249:Hormone Replacement Therapy / Q000379:methods; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D013965:Thyroidectomy / Q000379:methods*; D013967:Thyroiditis, Autoimmune / Q000175:diagnosis* / Q000628:therapy*; D013974:Thyroxine / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D007457:Iodine Radioisotopes; D013974:Thyroxine
keywords: Graves disease; Hashimoto disease; Hyperthyroidism; Hypothyroidism; Levothyroxine