title: Influences of obesity on the immunogenicity of Hepatitis B vaccine.
abstract: Hepatitis B vaccine is regarded as the most effective method for the prevention of hepatitis B virus (HBV) infection. However, several factors such as age, body mass index and immunocompetent state have been reported to be associated with reduced immunization responses. The present commentary was aimed to discuss the influences of obesity on the immunogenicity of hepatitis B vaccines.
  
  
  
  Available peer-reviewed literatures, practice guidelines, and statistics published on hepatitis B vaccine in obesity between 1973 and 2015.
  
  
  
  Obesity was significantly associated with non-response to hepatitis B vaccine immunization. The risk of nonresponsiveness of hepatitis B vaccine among obese people increased with BMI. Moreover, the obesity might lead to an increased risk of HBV vaccine-escape mutations. The mechanism responsible for decreased immunization responses in obesity included leptin-induced systemic and B cell intrinsic inflammation, impaired T cell responses and lymphocyte division and proliferation. Therefore, more studies should be performed to analyze the influences of obesity on the immunogenicity of hepatitis B vaccines to improve the immunoprotecive effect of hepatitis B vaccines in future.
authors.affiliation: a Suzhou Center for Disease Control and Prevention , Suzhou , China.
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
authors.affiliation: b Department of Epidemiology and Statistics , School of Public Health, Jiangsu Key Laboratory and Translational Medicine for Geriatric Disease, Medical College of Soochow University , Suzhou , Jiangsu , China.
authors.forename: Zhirong
authors.initials: Z
authors.lastname: Guo
authors.affiliation: b Department of Epidemiology and Statistics , School of Public Health, Jiangsu Key Laboratory and Translational Medicine for Geriatric Disease, Medical College of Soochow University , Suzhou , Jiangsu , China.
authors.forename: Chen
authors.initials: C
authors.lastname: Dong
mesh_terms: D001402:B-Lymphocytes / Q000276:immunology / Q000473:pathology; D015992:Body Mass Index; D005260:Female; D006509:Hepatitis B / Q000517:prevention & control; D006514:Hepatitis B Surface Antigens / Q000235:genetics / Q000276:immunology; D017325:Hepatitis B Vaccines / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*; D006515:Hepatitis B virus / Q000235:genetics / Q000276:immunology; D006801:Humans; D000071497:Immunogenicity, Vaccine; D007249:Inflammation; D008297:Male; D009765:Obesity / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology
chemical_list: D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines
keywords: hepatitis B vaccine; immunogenicity; obesity