title: Employing Metabolism to Improve the Diagnosis and Treatment of Pancreatic Cancer.
abstract: Pancreatic ductal adenocarcinoma is on pace to become the second leading cause of cancer-related death. The high mortality rate results from a lack of methods for early detection and the inability to successfully treat patients once diagnosed. Pancreatic cancer cells have extensively reprogrammed metabolism, which is driven by oncogene-mediated cell-autonomous pathways, the unique physiology of the tumor microenvironment, and interactions with non-cancer cells. In this review, we discuss how recent efforts delineating rewired metabolic networks in pancreatic cancer have revealed new in-roads to develop detection and treatment strategies for this dreadful disease.
authors.affiliation: Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Halbrook
authors.affiliation: Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: clyssiot@med.umich.edu.
authors.forename: Costas A
authors.initials: CA
authors.lastname: Lyssiotis
mesh_terms: D021441:Carcinoma, Pancreatic Ductal / Q000175:diagnosis / Q000378:metabolism* / Q000628:therapy; D065150:Cellular Reprogramming; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism; D005973:Glutamine / Q000378:metabolism; D006801:Humans; D008687:Metformin / Q000627:therapeutic use; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000628:therapy; D049268:Positron-Emission Tomography; D059016:Tumor Microenvironment
chemical_list: D005973:Glutamine; D019788:Fluorodeoxyglucose F18; D008687:Metformin; D005947:Glucose
keywords: FDG-PET; HP-MRI; Kras; PDAC; metabolic crosstalk; metabolic imaging; metabolic reprogramming; pancreatic cancer; stroma; tumor metabolism