title: Involvement of Reduced Microbial Diversity in Inflammatory Bowel Disease.
abstract: A considerable number of studies have been conducted to study the microbial profiles in inflammatory conditions. A common phenomenon in inflammatory bowel disease (IBD) is the reduction of the diversity of microbiota, which demonstrates that microbial diversity negatively correlates with disease severity in IBD. Increased microbial diversity is known to occur in disease remission. Species diversity plays an important role in maintaining the stability of the intestinal ecosystem as well as normal ecological function. A reduction in microbial diversity corresponds to a decrease in the stability of the ecosystem and can impair ecological function. Fecal microbiota transplantation (FMT), probiotics, and prebiotics, which aim to modulate the microbiota and restore its normal diversity, have been shown to be clinically efficacious. In this study, we hypothesized that a reduction in microbial diversity could play a role in the development of IBD.
authors.affiliation: Department of Central Laboratories and Gastroenterology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266071, China.
authors.forename: Dawei
authors.identifier: 0000-0003-3385-2704
authors.initials: D
authors.lastname: Gong
authors.affiliation: Department of Emergency Surgery, The Fifth People's Hospital of Ji'nan, Ji'nan 250022, China.
authors.forename: Xiaojie
authors.initials: X
authors.lastname: Gong
authors.affiliation: Department of Central Laboratories and Gastroenterology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266071, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Central Laboratories and Gastroenterology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266071, China.
authors.forename: Xinjuan
authors.initials: X
authors.lastname: Yu
authors.affiliation: Department of Central Laboratories and Gastroenterology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266071, China.
authors.forename: Quanjiang
authors.identifier: 0000-0002-5226-7853
authors.initials: Q
authors.lastname: Dong