title: Two-Dimensional Nanomaterials for Cancer Nanotheranostics.
abstract: Emerging nanotechnologies show unprecedented advantages in accelerating cancer theranostics. Among them, two-dimensional nanomaterials (2DNMs) represent a novel type of material with versatile physicochemical properties that have enabled a new horizon for applications in both cancer diagnosis and therapy. Studies have demonstrated that 2DNMs may be used in diverse aspects, including i) cancer detection due to their high propensity towards tumor markers; ii) molecular imaging for guided tumor therapies, and iii) drug and gene loading, photothermal and photodynamic cancer therapies. However, their biomedical applications raise concerns due to the limited understanding of their in vivo metabolism, transformation and possible toxicities. In this comprehensive review, the state-of-the-art development of 2DNMs and their implications for cancer nanotheranostics are presented. The modification strategies to enhance the biocompatibility of 2DNMs are also reviewed.
authors.affiliation: State Key Laboratory of Environmental, Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China.
authors.forename: Yongjiu
authors.initials: Y
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Environmental, Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China.
authors.forename: Yakun
authors.initials: Y
authors.lastname: Wu
authors.affiliation: School of Chemical Engineering, Dalian University of Technology, Dalian, 116024, China.
authors.forename: Bingbing
authors.initials: B
authors.lastname: Sun
authors.affiliation: State Key Laboratory of Environmental, Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China.
authors.forename: Sijin
authors.initials: S
authors.lastname: Liu
authors.affiliation: Beijing Key Laboratory of Bioprocess, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, China.
authors.forename: Huiyu
authors.initials: H
authors.lastname: Liu
mesh_terms: D000818:Animals; D006801:Humans; D049329:Nanostructures / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D009369:Neoplasms / Q000188:drug therapy* / Q000628:therapy*; D010778:Photochemotherapy / Q000379:methods; D000068936:Theranostic Nanomedicine / Q000379:methods*
keywords: bioimaging; cancer; drug delivery; nanotheranostics; two-dimensional nanomaterials