title: Gold-catalyzed sequential annulations towards 3,4-fused bi/tri-cyclic furans involving a [3+2+2]-cycloaddition.
abstract: A gold-catalyzed sequential annulation reaction to prepare 3,4-fused bicyclic furan compounds has been realized by employing 2-(1-alkynyl)-2-alken-1-ones and 1,3,5-triazines as the starting materials under mild reaction conditions. This protocol features multiple bond formation in a single operation with the incorporation of two nitrogen and two carbon atoms into the final products. A mechanistic investigation reveals that the sequential annulations involved an unprecedented stepwise [3+2+2]-cycloaddition.
authors.affiliation: Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, and School of Pharmaceutical Engineering & Life Science, Changzhou University, Changzhou 213164, P. R. China. jtsun@cczu.edu.cn jtsun08@gmail.com.
authors.forename: Suna
authors.initials: S
authors.lastname: Liu
authors.affiliation: Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, and School of Pharmaceutical Engineering & Life Science, Changzhou University, Changzhou 213164, P. R. China. jtsun@cczu.edu.cn jtsun08@gmail.com and School of Enviromental Science & Engineering, Tianjin University, Tianjin 300072, P. R. China.
authors.forename: Pu
authors.initials: P
authors.lastname: Yang
authors.affiliation: Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, and School of Pharmaceutical Engineering & Life Science, Changzhou University, Changzhou 213164, P. R. China. jtsun@cczu.edu.cn jtsun08@gmail.com.
authors.forename: Shiyong
authors.initials: S
authors.lastname: Peng
authors.affiliation: Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, and School of Pharmaceutical Engineering & Life Science, Changzhou University, Changzhou 213164, P. R. China. jtsun@cczu.edu.cn jtsun08@gmail.com.
authors.forename: Chenghao
authors.initials: C
authors.lastname: Zhu
authors.affiliation: Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, and School of Pharmaceutical Engineering & Life Science, Changzhou University, Changzhou 213164, P. R. China. jtsun@cczu.edu.cn jtsun08@gmail.com.
authors.forename: Shengyu
authors.initials: S
authors.lastname: Cao
authors.affiliation: Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, and School of Pharmaceutical Engineering & Life Science, Changzhou University, Changzhou 213164, P. R. China. jtsun@cczu.edu.cn jtsun08@gmail.com.
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.affiliation: Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, and School of Pharmaceutical Engineering & Life Science, Changzhou University, Changzhou 213164, P. R. China. jtsun@cczu.edu.cn jtsun08@gmail.com.
authors.forename: Jiangtao
authors.identifier: http://orcid.org/0000-0003-2516-3466
authors.initials: J
authors.lastname: Sun