title: Triglyceride to HDL-C Ratio is Associated with Insulin Resistance in Overweight and Obese Children.
abstract: The purpose of this study was to investigate the usefulness of triglyceride to hdl-c ratio (TG:HDL-C) as an insulin resistance (IR) marker for overweight and obese children. A total of 271 blood samples of obese and overweight children aged 9-16 years were analysed for fasting glucose, lipids and insulin. Children were divided into IR and non-insulin resistance, using homeostasis model assessment (HOMA). The children were then stratified by tertiles of TG: HDL-C ratio. The strength between TG:HDL-C ratio and other parameters of IR were quantified using Pearson correlation coefficient (r). Odds ratio was estimated using multiple logistic regression adjusted for age, gender, pubertal stages and IR potential risk factors. Children with IR had significantly higher TG:HDL-C ratio (2.48) (p = 0.01). TG:HDL-C ratio was significantly correlated with HOMA-IR (r = 0.104, p < 0.005) and waist circumference (r = 0.134, p < 0.001). Increasing tertiles of TG:HDL-C ratio showed significant increase in mean insulin level (p = 0.03), HOMA-IR (p = 0.04) and significantly higher number of children with acanthosis nigricans and metabolic syndrome. The odds of having IR was about 2.5 times higher (OR = 2.47; 95% CI 1.23, 4.95; p = 0.01) for those in the highest tertiles of TG:HDL-C ratio. Hence, TG:HDL-C may be a useful tool to identify high risk individuals.
authors.affiliation: Department of Paediatrics, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.|Diabetes and Endocrine Unit, Institute For Medical Research, Kuala Lumpur, Malaysia.
authors.forename: Nur Ahmad Kamil Zati
authors.initials: NA
authors.lastname: Iwani
authors.affiliation: Department of Paediatrics, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: Muhammad Yazid
authors.initials: MY
authors.lastname: Jalaludin
authors.affiliation: Department of Paediatrics, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.|Diabetes and Endocrine Unit, Institute For Medical Research, Kuala Lumpur, Malaysia.
authors.forename: Ruziana Mona Wan Mohd
authors.initials: RM
authors.lastname: Zin
authors.affiliation: Department of Paediatrics, Putrajaya Hospital, Putrajaya, Malaysia.
authors.forename: Md Zain
authors.initials: MZ
authors.lastname: Fuziah
authors.affiliation: Department of Paediatrics, Putrajaya Hospital, Putrajaya, Malaysia.
authors.forename: Janet Yeow Hua
authors.initials: JY
authors.lastname: Hong
authors.affiliation: Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: Yahya
authors.initials: Y
authors.lastname: Abqariyah
authors.affiliation: Department of Sports Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: Abdul Halim
authors.initials: AH
authors.lastname: Mokhtar
authors.affiliation: Diabetes and Endocrine Unit, Institute For Medical Research, Kuala Lumpur, Malaysia.
authors.forename: Wan Mohamud
authors.initials: WM
authors.lastname: Wan Nazaimoon
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood*; D001786:Blood Glucose / Q000032:analysis; D002648:Child; D008076:Cholesterol, HDL / Q000097:blood*; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D050177:Overweight / Q000150:complications* / Q000473:pathology*; D014280:Triglycerides / Q000097:blood*
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D008076:Cholesterol, HDL; D007328:Insulin; D014280:Triglycerides