title: Time-course of Serum Pro-inflammatory Cytokines and Chemokines Levels Observed in Granulomatosis with Polyangiitis: A Case Report.
abstract: A 77-year-old man visited our hospital with chief complaints of difficulty in hearing, nasal discharge and fever. The patients was diagnosed with otitis media, and his fever continued at approximately 38°C despite the administration of clarithromycin. After that, dyspnea on exertion developed and chest X-ray examination indicated multiple infiltrative shadows. PR3-ANCA levels were high (238-fold of the normal levels), and granulomatosis with polyangiitis (GPA) was diagnosed on the basis of clinical symptoms, laboratory results, and pathological findings. Thus, remission induction therapy was initiated with prednisolone and cyclophosphamide, following which symptoms and imaging findings rapidly improved. Blood concentrations of tumor necrosis factor-α, interleukin-8, and growth-related oncogene that had been measured since before treatment decreased over time with the improvement of lesions following treatment.
authors.affiliation: Nihon University School of Medicine. kozu.yutaka@nihon-u.ac.jp.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Kozu
authors.forename: Yusuhiro
authors.initials: Y
authors.lastname: Gon
authors.forename: Yuki
authors.initials: Y
authors.lastname: Takano
authors.forename: Takao
authors.initials: T
authors.lastname: Noguchi
authors.forename: Shinichi
authors.initials: S
authors.lastname: Hayashi
authors.forename: Fumio
authors.initials: F
authors.lastname: Kumasawa
authors.forename: Kenji
authors.initials: K
authors.lastname: Mizumura
authors.forename: Shuichiro
authors.initials: S
authors.lastname: Maruoka
authors.forename: Shu
authors.initials: S
authors.lastname: Hashimoto
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D018925:Chemokines / Q000097:blood* / Q000276:immunology; D003520:Cyclophosphamide / Q000627:therapeutic use; D016207:Cytokines / Q000097:blood* / Q000276:immunology; D004359:Drug Therapy, Combination; D005938:Glucocorticoids / Q000627:therapeutic use; D014890:Granulomatosis with Polyangiitis / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D018836:Inflammation Mediators / Q000097:blood* / Q000276:immunology; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use; D012074:Remission Induction; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D018925:Chemokines; D016207:Cytokines; D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D018836:Inflammation Mediators; D003520:Cyclophosphamide; D011239:Prednisolone
keywords: Granulomatosis with polyangiitis； interleukin-8； tumor necrosis factor-α； growth-related oncogenepolyangiitis, interleukin-8, tumor necrosis factor-α, growth-related oncogene