title: Elevated serum interferon γ-inducible protein-10 in women with polycystic ovary syndrome.
abstract: BACKGROUND
  Interferon γ-induced protein 10 kDa (IP10/CXCL10) is a chemokine related to endocrine disorders; however, the serum concentrations of IP10 in women with polycystic ovary syndrome (PCOS) have not yet been reported. Therefore, we investigated whether IP10 is increased in PCOS patients and its potential clinical value in PCOS patients.
  
  
  METHODS
  For this research, the serum IP10, glucose, insulin, high sensitivity C-reactive protein (hs-CRP), follicle-stimulating hormone (FSH), luteinizing hormone (LH) and total testosterone (TT) concentrations were measured in 60 women with PCOS and healthy controls.
  
  
  RESULTS
  The median IP10 concentration was 45.60 pg/mL [interquartile range (IQR):29.75, 79.69], which was significantly higher than that of the body mass index (BMI)-matched controls (median: 36.46 pg/mL; IQR:28.98, 45.80). In the multivariate linear regression analysis, hs-CRP and the homeostasis model assessment of insulin resistance index (HOMA2-IR) were independent predictors of the IP10 values, while FSH was inversely associated with the IP10.No significant association was observed between the IP10 and BMI, glucose, LH and TT.
  
  
  CONCLUSIONS
  The serum IP10 concentrations increase in women with PCOS, moreover, IP10 appears to be correlated with the inflammatory and IR statuses of PCOS. IP10 may be a potential biomarker to estimate the disease activity of PCOS.
authors.affiliation: a Department of Clinical Laboratory , Affiliated Liuyang Hospital of University of South China, People's Hospital of Liuyang City , Changsha , Hunan , China.
authors.forename: Hongli
authors.initials: H
authors.lastname: Deng
authors.affiliation: a Department of Clinical Laboratory , Affiliated Liuyang Hospital of University of South China, People's Hospital of Liuyang City , Changsha , Hunan , China.
authors.forename: Zhibo
authors.initials: Z
authors.lastname: Li
authors.affiliation: a Department of Clinical Laboratory , Affiliated Liuyang Hospital of University of South China, People's Hospital of Liuyang City , Changsha , Hunan , China.
authors.forename: Guang
authors.initials: G
authors.lastname: Liu
authors.affiliation: a Department of Clinical Laboratory , Affiliated Liuyang Hospital of University of South China, People's Hospital of Liuyang City , Changsha , Hunan , China.
authors.forename: Xianhua
authors.initials: X
authors.lastname: Li
authors.affiliation: b Department of Clinical Laboratory , Affiliated Changsha Hospital of University of South China, The First Hospital of Changsha City , Changsha , Hunan , China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Chen
authors.affiliation: c Department of Gastrointestinal Surgery , Affiliated Liuyang Hospital of University of South China, People's Hospital of Liuyang City , Chang sha , Hunan , China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: d Department of Clinical Laboratory , Third Afﬁliated Hospital of Guangxi University of Chinese Medicine , Liuzhou , Guangxi , China , and.
authors.forename: Yifan
authors.initials: Y
authors.lastname: Sun
authors.affiliation: e Department of Clinical Laboratory , Liuzhou Maternity and Child Health Care Hospital , Liuzhou , Guangxi , China.
authors.forename: Jinjian
authors.initials: J
authors.lastname: Fu
mesh_terms: D000328:Adult; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D054357:Chemokine CXCL10 / Q000097:blood*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007333:Insulin Resistance; D007986:Luteinizing Hormone / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D055815:Young Adult
chemical_list: C114753:CXCL10 protein, human; D054357:Chemokine CXCL10; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D002097:C-Reactive Protein
keywords: Biomarker; inflammatory; insulin resistance; interferon γ-induced protein 10; polycystic ovary syndrome