title: The thyroid hormone nuclear receptors and the Wnt/β-catenin pathway: An intriguing liaison.
abstract: The thyroid hormones, T3 and T4, control several developmental and homeostatic processes. From a molecular point of view, most of their actions depend on the activity of the thyroid hormone nuclear receptors (TRs), which are T3-modulated transcription factors. Recent studies have not only highlighted that the physiological response induced by T3 within a cell depends on the expression of specific TRs, but also that the functions of TRs are coordinated by and integrated in other signalling pathways. This is particularly the case for the multilevel interactions between TRs and the Wnt signalling pathway. Interestingly both signals are involved in development and homeostasis, and their alterations are responsible for the development of pathologies, such as cancer. Here, we present findings on the complex crosstalk between TRs and Wnt in several organisms and in different tissue contexts, and speculate on the biological relevance of modulating TR-Wnt functionality in therapeutic approaches aimed to target cancer cells or applications for regenerative medicine.
authors.affiliation: Centre de Recherche en Cancérologie de Lyon, INSERM U1052, CNRS UMR5286, Université de Lyon, Université Lyon 1, Centre Léon Bérard, Département de la recherche, 69373 Lyon, France.
authors.forename: Seham
authors.initials: S
authors.lastname: Skah
authors.affiliation: Centre de Recherche en Cancérologie de Lyon, INSERM U1052, CNRS UMR5286, Université de Lyon, Université Lyon 1, Centre Léon Bérard, Département de la recherche, 69373 Lyon, France.
authors.forename: Joel
authors.initials: J
authors.lastname: Uchuya-Castillo
authors.affiliation: Centre de Recherche en Cancérologie de Lyon, INSERM U1052, CNRS UMR5286, Université de Lyon, Université Lyon 1, Centre Léon Bérard, Département de la recherche, 69373 Lyon, France. Electronic address: sirakovmaria@gmail.com.
authors.forename: Maria
authors.initials: M
authors.lastname: Sirakov
authors.affiliation: Centre de Recherche en Cancérologie de Lyon, INSERM U1052, CNRS UMR5286, Université de Lyon, Université Lyon 1, Centre Léon Bérard, Département de la recherche, 69373 Lyon, France. Electronic address: michelina.plateroti@univ-lyon1.fr.
authors.forename: Michelina
authors.initials: M
authors.lastname: Plateroti
mesh_terms: D006801:Humans; D011988:Receptors, Thyroid Hormone / Q000378:metabolism*; D013974:Thyroxine / Q000378:metabolism*; D014284:Triiodothyronine / Q000378:metabolism*; D051153:Wnt Proteins / Q000378:metabolism*; D060449:Wnt Signaling Pathway; D051176:beta Catenin / Q000378:metabolism*
chemical_list: D011988:Receptors, Thyroid Hormone; D051153:Wnt Proteins; D051176:beta Catenin; D014284:Triiodothyronine; D013974:Thyroxine
keywords: Stem cells; Thyroid hormone; Thyroid hormone nuclear receptor; Wnt/β-catenin