title: Association Between Use of Cannabis in Adolescence and Weight Change into Midlife.
abstract: Cannabis use has been found to stimulate appetite and potentially promote weight gain via activation of the endocannabinoid system. Despite the fact that the onset of cannabis use is typically during adolescence, the association between adolescence cannabis use and long-term change in body weight is generally unknown. This study aims to examine the association between adolescence cannabis use and weight change to midlife, while accounting for the use of other substances. The study applied 20 to 22 years of follow-up data on 712 Danish adolescents aged between 15 and 19 years at baseline. Self-reported height and weight, cannabis, cigarette and alcohol use, socioeconomic status (SES) and physical activity levels were assessed in baseline surveys conducted in 1983 and 1985. The follow-up survey was conducted in 2005. In total 19.1% (n = 136) of adolescents reported having used/using cannabis. Weight gain between adolescence and midlife was not related to cannabis exposure during adolescence in either crude or adjusted models, and associations were not modified by baseline alcohol intake or smoking. However, cannabis use was significantly associated with cigarette smoking (p<0.001) and alcohol intake (p<0.001) and inversely associated with physical activity levels (p = 0.04). In conclusion, this study does not provide evidence of an association between adolescence cannabis use and weight change from adolescence to midlife.
authors.affiliation: School of Molecular Bioscience, University of Sydney, Camperdown, New South Wales, Australia.
authors.forename: Lexie Zhiyan
authors.initials: LZ
authors.lastname: Jin
authors.affiliation: School of Molecular Bioscience, University of Sydney, Camperdown, New South Wales, Australia.
authors.forename: Anna
authors.initials: A
authors.lastname: Rangan
authors.affiliation: Coordinating Research Centre, Frederiksberg Hospital, The Capital Region, Frederiksberg, Denmark.
authors.forename: Jesper
authors.initials: J
authors.lastname: Mehlsen
authors.affiliation: Exercise Epidemiology Unit, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.
authors.forename: Lars Bo
authors.initials: LB
authors.lastname: Andersen
authors.affiliation: Research unit for Dietary Studies, the Parker Institute, Frederiksberg and Bispebjerg Hospitals, The Capital Region, Frederiksberg, Denmark.
authors.forename: Sofus C
authors.initials: SC
authors.lastname: Larsen
authors.affiliation: Research unit for Dietary Studies, the Parker Institute, Frederiksberg and Bispebjerg Hospitals, The Capital Region, Frederiksberg, Denmark.|The Institute of Public Health, Section for General Medicine, University of Copenhagen, Copenhagen, Denmark.|Boden Institute of Obesity, Nutrition Exercise & Eating Disorders, University of Sydney, Camperdown, New South Wales, Australia.|National Institute of Public Health, University of Southern Denmark, Odense, Denmark.
authors.forename: Berit L
authors.initials: BL
authors.lastname: Heitmann
mesh_terms: D000293:Adolescent; D000367:Age Factors; D000428:Alcohol Drinking; D015992:Body Mass Index; D001835:Body Weight; D002188:Cannabis / Q000009:adverse effects; D003718:Denmark / Q000453:epidemiology; D015444:Exercise; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D002189:Marijuana Abuse / Q000453:epidemiology*; D008385:Marijuana Smoking / Q000009:adverse effects; D064086:Medical Marijuana / Q000008:administration & dosage / Q000009:adverse effects; D011159:Population Surveillance; D012307:Risk Factors; D057566:Self Report; D012907:Smoking; D012923:Social Class; D055815:Young Adult
chemical_list: D064086:Medical Marijuana