title: Magnetic nanoparticles-based drug and gene delivery systems for the treatment of pulmonary diseases.
abstract: Magnetic nanoparticles (MNPs) have gained much attention due to their unique properties such as biocompatibility and biodegradability as well as magnetic and heat-medicated characteristics. Due to these inherent properties, MNPs have been widely used in various biomedical applications including targeted drug delivery and hyperthermia-based therapy. Hyperthermia is a promising approach for the thermal activation therapy of several diseases, including pulmonary diseases. Additionally, due to their large loading capacity and controlled release ability, several MNP-based drug delivery systems have been emerged for treatment of cystic fibrosis and lung cancer. This review provides an overview on the unique properties of MNPs and magnetic-mediated hyperthermia with emphasis on the recent biomedical applications of MNPs in treatment of both lung cancer and cystic fibrosis.
authors.affiliation: Nanomaterials Laboratory, Center for Materials Science, Zewail City of Science & Technology, 6th October City, 12588 Giza, Egypt.
authors.forename: Ibrahim M
authors.initials: IM
authors.lastname: El-Sherbiny
authors.affiliation: Nanomaterials Laboratory, Center for Materials Science, Zewail City of Science & Technology, 6th October City, 12588 Giza, Egypt.
authors.forename: Nancy M
authors.initials: NM
authors.lastname: Elbaz
authors.affiliation: Nanomaterials Laboratory, Center for Materials Science, Zewail City of Science & Technology, 6th October City, 12588 Giza, Egypt.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Sedki
authors.affiliation: Nanomaterials Laboratory, Center for Materials Science, Zewail City of Science & Technology, 6th October City, 12588 Giza, Egypt.
authors.forename: Abdulaziz
authors.initials: A
authors.lastname: Elgammal
authors.affiliation: Harefield Heart Science Centre, National Heart & Lung Institute, Imperial College, London, UK.
authors.forename: Magdi H
authors.initials: MH
authors.lastname: Yacoub
mesh_terms: D000818:Animals; D003550:Cystic Fibrosis / Q000473:pathology / Q000628:therapy*; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000627:therapeutic use; D016503:Drug Delivery Systems / Q000379:methods*; D018014:Gene Transfer Techniques; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000473:pathology / Q000628:therapy*; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use*
chemical_list: D003692:Delayed-Action Preparations; D058185:Magnetite Nanoparticles
keywords: cystic fibrosis; hyperthermia; iron oxide nanoparticles; lung cancer; magnetic nanoparticles; targeted drug delivery