title: [Vitamin D and parathyroid hormone levels and bone mineral density in patients undergoing hematopoietic cell transplantation].
abstract: BACKGROUND
  Patients undergoing hematopoietic cell transplantation (HCT) are at increased risk of developing osteoporosis.
  
  
  OBJECTIVE
  To determine the frequency and severity of Vitamin D deficiency, secondary hyperparathyroidism and low bone mass in patients undergoing HCT.
  
  
  METHODS
  Analysis of the database of patients undergoing HCT in our institution in the 2010-2015 period. We searched for patients with measurements of 25-OH vitamin D (25OHD), parathyroid hormone (PTH) and bone densitometry by double beam X ray absorptiometry (DXA) prior and up to one year after HCT.
  
  
  RESULTS
  Ninety patients were included, 53 were evaluated prior to HCT and 37 after HCT. They represent 73% of all patients undergoing HCT in the period. Median 25OHD was 12 ng/ml (range 4-41.4). Ninety seven percent of patients had levels considered insufficient and 85% compatible with deficiency. Median PTH was 60.5 pg/ml (range 21-186). Forty five percent of patients had secondary hyperparathyroidism. DXA was performed in 65 patients (prior to HCT in 54 and after HCT in 11). Of these, 11% had had a low bone mineral density.
  
  
  CONCLUSIONS
  Patients undergoing HCT have a high risk of vitamin D deficiency, secondary hyperparathyroidism and low bone mineral density.
authors.affiliation: Departamento de Endocrinología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile, pflorenz@uc.cl.
authors.forename: Pablo
authors.initials: P
authors.lastname: Florenzano
authors.affiliation: Departamento de Hemato-Oncología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
authors.forename: Daniel
authors.initials: D
authors.lastname: Ernst
authors.affiliation: Departamento de Endocrinología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile, pflorenz@uc.cl.
authors.forename: Nicole
authors.initials: N
authors.lastname: Lustig
authors.affiliation: Departamento de Hemato-Oncología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
authors.forename: Patricio
authors.initials: P
authors.lastname: Rojas
authors.affiliation: Departamento de Hemato-Oncología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
authors.forename: Pablo
authors.initials: P
authors.lastname: Ramírez
authors.affiliation: Departamento de Endocrinología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile, pflorenz@uc.cl.
authors.forename: Claudia
authors.initials: C
authors.lastname: Campusano
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015519:Bone Density; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000209:etiology; D010281:Parathyroid Hormone / Q000032:analysis*; D012189:Retrospective Studies; D014807:Vitamin D / Q000032:analysis*; D014808:Vitamin D Deficiency / Q000209:etiology*; D055815:Young Adult
chemical_list: D010281:Parathyroid Hormone; D014807:Vitamin D