title: Genetic variants of the gasdermin B gene associated with the development of aspirin-exacerbated respiratory diseases.
abstract: BACKGROUND
  Aspirin-exacerbated respiratory disease (AERD) is characterized by a severe and sudden asthma attack after aspirin ingestion in patients with asthma. We studied associations with six common single nucleotide polymorphisms (SNP) of the gasdermin B gene (GSDMB).
  
  
  OBJECTIVE
  DNA obtained from 572 patients with asthma (with AERD, n = 165; and with aspirin-tolerant asthma, n = 407) and 391 normal controls was subjected to genotyping of six SNPs of GSDMB.
  
  
  METHODS
  An association analysis between GSDMB variants and AERD, with a fall rate of the forced expiratory volume in the first second of expiration (FEV1), was performed by using logistic and regression models.
  
  
  RESULTS
  Two SNPs in the intron (rs870830, rs7216389) showed significant associations with AERD (minimum p = 7.00 × 10-4 in the dominant model), even after Bonferroni correction (pcorr = 0.01 for the rs870830). Regression analysis of the genetic variants with FEV1 revealed significant associations with rs870830 and the haplotype 2 (pcorr = 4.71 × 10-4 for rs870830 and pcorr = 1.14 × 10-3 for haplotype 2, respectively).
  
  
  CONCLUSIONS
  We found strong associations among GSDMB polymorphisms and the presence of AERD and FEV1 in Korean patients with asthma. Our findings indicated that genetic variations of GSDMB may be associated with the development of AERD and aspirin-induced bronchospasm.
authors.forename: Lyoung Hyo
authors.initials: LH
authors.lastname: Kim
authors.forename: HunSoo
authors.initials: H
authors.lastname: Chang
authors.forename: Suhg
authors.initials: S
authors.lastname: Namgoong
authors.forename: Ji On
authors.initials: JO
authors.lastname: Kim
authors.forename: Hyun Sub
authors.initials: HS
authors.lastname: Cheong
authors.forename: Seo-Gyeong
authors.initials: SG
authors.lastname: Lee
authors.forename: Jong Sook
authors.initials: JS
authors.lastname: Park
authors.forename: Ae Rin
authors.initials: AR
authors.lastname: Baek
authors.forename: So-My
authors.initials: SM
authors.lastname: Koo
authors.forename: Inseon S
authors.initials: IS
authors.lastname: Choi
authors.forename: Mi-Kyeong
authors.initials: MK
authors.lastname: Kim
authors.forename: Hea-Sim
authors.initials: HS
authors.lastname: Park
authors.forename: Choon-Sik
authors.initials: CS
authors.lastname: Park
authors.forename: Hyoung Doo
authors.initials: HD
authors.lastname: Shin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D055963:Asthma, Aspirin-Induced / Q000175:diagnosis* / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D019295:Computational Biology / Q000379:methods; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007438:Introns; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009363:Neoplasm Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012129:Respiratory Function Tests; D055815:Young Adult; D000094524:Gasdermins
chemical_list: D009363:Neoplasm Proteins; C527978:GSDMB protein, human; D000094524:Gasdermins