title: Polymorphisms in Telomere Length Associated TERC and TERT predispose for Ischemic Stroke in a Chinese Han population.
abstract: The role of telomere in genomic stability is an established fact. Variation in leukocyte telomere length (LTL) has been considered a crucial factor that associated with age-associated diseases. To elucidate the association between LTL variation and ischemic stroke (IS) risk, we selected ten single nucleotide polymorphisms (SNPs) in three genes (TERC, TERT and RTEL1) that previously reported link to LTL, and genotyped SNPs of these genes in a case-control study. The association between polymorphisms and IS risk were tested by Chi squared test and haplotype analysis. In allele association analysis, allele "C" in rs10936599 of TERC gene and allele "G" in rs2853677 of TERT gene were found to have an increased risk of IS when compared with allele "T" and "A", respectively. Model association analysis showed that genotype "G/A" in the overdominant model and genotypes "G/A" and "A/A" in the dominant model of rs2242652 presented a more likelihood to have IS. Another TERT locus (rs2853677) with genotype "G" was also found IS-related risky in the log-additive model. Taken together, our results suggest a potential association between LTL related TERC, TERT gene variants and ischemic stroke risk.
authors.affiliation: Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, P. R. China.|Shaanxi Provincial Research Center for the Project of Prevention and Treatment of Respiratory Diseases, Xi'an 710061, P. R. China.
authors.forename: Shuo
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, P. R. China.|Shaanxi Provincial Research Center for the Project of Prevention and Treatment of Respiratory Diseases, Xi'an 710061, P. R. China.|Department of Respiratory Medicine, Xi'an 141 Hospital, Xi'an 710089, P. R. China.
authors.forename: Guofa
authors.initials: G
authors.lastname: Ji
authors.affiliation: Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, P. R. China.|Shaanxi Provincial Research Center for the Project of Prevention and Treatment of Respiratory Diseases, Xi'an 710061, P. R. China.
authors.forename: Yiqian
authors.initials: Y
authors.lastname: Liang
authors.affiliation: Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, P. R. China.|Shaanxi Provincial Research Center for the Project of Prevention and Treatment of Respiratory Diseases, Xi'an 710061, P. R. China.|Department of Respiratory Medicine, Hospital of Lantian County, Xi'an 710500, P.R. China.
authors.forename: Rui
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, P. R. China.|Shaanxi Provincial Research Center for the Project of Prevention and Treatment of Respiratory Diseases, Xi'an 710061, P. R. China.
authors.forename: Puyu
authors.initials: P
authors.lastname: Shi
authors.affiliation: Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, P. R. China.|Shaanxi Provincial Research Center for the Project of Prevention and Treatment of Respiratory Diseases, Xi'an 710061, P. R. China.|Department of Internal Medicine, Shaanxi Normal University Hospital, Xi'an 710062, P. R. China.
authors.forename: Dangshe
authors.initials: D
authors.lastname: Guo
authors.affiliation: Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, P. R. China.|Shaanxi Provincial Research Center for the Project of Prevention and Treatment of Respiratory Diseases, Xi'an 710061, P. R. China.|Department of Internal Medicine, Xi'an International Studies University Hospital, Xi'an 710061, P. R. China.
authors.forename: Chunqi
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, P. R. China.|Shaanxi Provincial Research Center for the Project of Prevention and Treatment of Respiratory Diseases, Xi'an 710061, P. R. China.
authors.forename: Jing
authors.initials: J
authors.lastname: Feng
authors.affiliation: Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, P. R. China.|Shaanxi Provincial Research Center for the Project of Prevention and Treatment of Respiratory Diseases, Xi'an 710061, P. R. China.
authors.forename: Feng
authors.initials: F
authors.lastname: Liu
authors.affiliation: Medical Information Management Office, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, P. R. China.
authors.forename: Rong
authors.initials: R
authors.lastname: Peng
authors.affiliation: Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, P. R. China.|Shaanxi Provincial Research Center for the Project of Prevention and Treatment of Respiratory Diseases, Xi'an 710061, P. R. China.
authors.forename: Mingwei
authors.initials: M
authors.lastname: Chen
mesh_terms: D044466:Asian People / Q000235:genetics; D002545:Brain Ischemia / Q000150:complications / Q000235:genetics*; D002681:China; D004265:DNA Helicases / Q000235:genetics; D006801:Humans; D007962:Leukocytes / Q000378:metabolism*; D020641:Polymorphism, Single Nucleotide; D012313:RNA / Q000235:genetics*; D020521:Stroke / Q000150:complications / Q000235:genetics*; D019098:Telomerase / Q000235:genetics*; D016615:Telomere / Q000378:metabolism*; D059505:Telomere Homeostasis
chemical_list: C422952:telomerase RNA; D012313:RNA; C509186:TERT protein, human; D019098:Telomerase; C532890:RTEL1 protein, human; D004265:DNA Helicases