title: Baseline General Characteristics of the Korean Chronic Kidney Disease: Report from the KoreaN Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD).
abstract: The KoreaN Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD) was developed to investigate various clinical courses and risk factors for progression of Korean chronic kidney disease (CKD). The KNOW-CKD study consists of nine clinical centers in Korea, and patients aged between 20 and 75 years with CKD from stage 1 to 5 (predialysis) were recruited. At baseline, blood and urine samples were obtained and demographic data including comorbidities, drugs, quality of life, and health behaviors were collected. Estimated glomerular filtration rate (eGFR) was calculated by 4-variable Modification of Diet in Renal Disease (MDRD) equation using isotope dilution mass spectrometry (IDMS)-calibrated serum creatinine measured at a central laboratory. As a dynamic cohort, a total of 2,341 patients were enrolled during the enrollment period from 2011 until 2015, among whom 2,238 subjects were finally analyzed for baseline profiles. The mean age of the cohort was 53.7 ± 12.2 year and 61.2% were men. Mean eGFR was 50.5 ± 30.3 mL/min/1.73 m². The participants with lower eGFR had a tendency to be older, with more comorbidities, to have higher systolic blood pressure (BP) and pulse pressure, with lower income level and education attainment. The patients categorized as glomerulonephritis (GN) were 36.2% followed by diabetic nephropathy (DN, 23.2%), hypertensive nephropathy (HTN, 18.3%), polycystic kidney disease (PKD, 16.3%), and other unclassified disease (6.1%). The KNOW-CKD participants will be longitudinally followed for 10 years. The study will provide better understanding for physicians regarding clinical outcomes, especially renal and cardiovascular outcomes in CKD patients.
authors.affiliation: Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
authors.forename: Eunjeong
authors.identifier: http://orcid.org/0000-0002-2191-2784
authors.initials: E
authors.lastname: Kang
authors.affiliation: Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
authors.forename: Miyeun
authors.identifier: http://orcid.org/0000-0001-7304-2496
authors.initials: M
authors.lastname: Han
authors.affiliation: Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
authors.forename: Hyunsuk
authors.identifier: http://orcid.org/0000-0001-9783-6872
authors.initials: H
authors.lastname: Kim
authors.affiliation: Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Sue Kyung
authors.identifier: http://orcid.org/0000-0001-5002-9707
authors.initials: SK
authors.lastname: Park
authors.affiliation: Medical Research Collaborating Center, Seoul National University Hospital and Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Joongyub
authors.identifier: http://orcid.org/0000-0003-2784-3772
authors.initials: J
authors.lastname: Lee
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Young Youl
authors.identifier: http://orcid.org/0000-0002-4204-9908
authors.initials: YY
authors.lastname: Hyun
authors.affiliation: Department of Internal Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Korea.
authors.forename: Yong Soo
authors.identifier: http://orcid.org/0000-0003-2152-1289
authors.initials: YS
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Gachon University, Gil Hospital, Incheon, Korea.
authors.forename: Wookyung
authors.identifier: http://orcid.org/0000-0001-7657-130X
authors.initials: W
authors.lastname: Chung
authors.affiliation: Department of Internal Medicine, Dongguk University Gyeongju Hospital, Gyeongju, Korea.
authors.forename: Hyo Jin
authors.identifier: http://orcid.org/0000-0001-9289-9073
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea.
authors.forename: Yun Kyu
authors.identifier: http://orcid.org/0000-0001-8632-5743
authors.initials: YK
authors.lastname: Oh
authors.affiliation: Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
authors.forename: Curie
authors.identifier: http://orcid.org/0000-0001-7033-1102
authors.initials: C
authors.lastname: Ahn
authors.affiliation: Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea. khoh@snu.ac.kr.
authors.forename: Kook Hwan
authors.identifier: http://orcid.org/0000-0001-9525-2179
authors.initials: KH
authors.lastname: Oh
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D044466:Asian People; D015331:Cohort Studies; D003404:Creatinine / Q000097:blood; D003710:Demography; D003928:Diabetic Nephropathies / Q000150:complications; D005260:Female; D005919:Glomerular Filtration Rate; D005921:Glomerulonephritis / Q000150:complications; D006801:Humans; D006977:Hypertension, Renal / Q000150:complications; D008297:Male; D008875:Middle Aged; D009393:Nephritis / Q000150:complications; D007690:Polycystic Kidney Diseases / Q000150:complications; D051436:Renal Insufficiency, Chronic / Q000209:etiology / Q000473:pathology*; D056910:Republic of Korea; D012307:Risk Factors; D012720:Severity of Illness Index
chemical_list: D003404:Creatinine
keywords: Chronic Kidney Disease; Cohort; Diabetes; Epidemiology; Glomerulonephritis; Hypertension; Polycystic Kidney Disease