title: Mitochondrial Lon1 has a role in homeostasis of the mitochondrial ribosome and pentatricopeptide repeat proteins in plants.
abstract: Lon is a highly conserved protein family in eukaryotes and eubacteria and its members all contain both a chaperone and a proteolytic domain that are important for Lon function. Loss of mitochondrial Lon1 leads to deleterious phenotypes in yeast and plants, and causes developmental disorders and aging-related diseases in humans. In Arabidopsis, we have recently reported the multiple roles of Lon1 in mitochondrial protein homeostasis through an evaluation of changes in protein degradation rates in the absence of Lon1.1In this addendum, we extend our discussion to the roles of Lon1 in mitochondrial post-transcriptional regulation by considering the effects of its loss on ribosome proteins required for protein synthesis and mitochondrial PPR proteins required for RNA regulation.
authors.affiliation: a ARC Centre of Excellence in Plant Energy Biology , The University of Western Australia , Crawley , WA , Australia.
authors.forename: Lei
authors.initials: L
authors.lastname: Li
authors.affiliation: a ARC Centre of Excellence in Plant Energy Biology , The University of Western Australia , Crawley , WA , Australia.
authors.forename: A Harvey
authors.initials: AH
authors.lastname: Millar
authors.affiliation: a ARC Centre of Excellence in Plant Energy Biology , The University of Western Australia , Crawley , WA , Australia.
authors.forename: Shaobai
authors.initials: S
authors.lastname: Huang
mesh_terms: D017360:Arabidopsis / Q000235:genetics / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism*; D018506:Gene Expression Regulation, Plant; D006706:Homeostasis; D000069396:Mitochondrial Ribosomes / Q000378:metabolism*; D012697:Serine Endopeptidases / Q000235:genetics / Q000378:metabolism*
chemical_list: D029681:Arabidopsis Proteins; C538752:pentatricopeptide repeat protein, Arabidopsis; C579791:Lon1 protein, Arabidopsis; D012697:Serine Endopeptidases
keywords: Lon1; mitochondria; mitoribosome; pentratricopeptide repeat protein (PPR); protein homeostasis