title: Therapeutic efficacy of tadalafil and eriythropoietin in experimental spinal cord injury.
abstract: BACKGROUND
  This experimental study was an investigation of the efficacy of erythropoietin and tadalafil in rats with induced spinal cord injury (SCI).
  
  
  METHODS
  Thirty-five Sprague Dawley rats were distributed into 5 groups. First group was used for normal biochemical values. Spinal cord injury was induced in 4 remaining groups with clip compression technique after laminectomy process to T10 vertebra. Second group was designated solvent group and received 1 cc physiological serum after injury. Third group was medicated with intraperitoneal 2000 u/kg single dose erythropoietin after injury. Orogastric 2 mg/kg single dose tadalafil was administered to fourth group after injury. Fifth group did not receive any treatment and was used for biochemical values with injury. All subjects were sacrificed 48 hours after application. Malondialdehyde (MDA) and total antioxidant capacity (TAOC) values were evaluated using blood and tissue samples.
  
  
  RESULTS
  Lowest serum and tissue MDA values were found in group with erythropoietin intake. While highest serum TAOC values of all groups were seen in tadalafil group, highest tissue TAOC values were observed in group given erythropoietin.
  
  
  CONCLUSIONS
  It was concluded that by decreasing oxidative stress, tadalafil and erythropoietin can inhibit secondary damage in SCI.
authors.affiliation: Department of Neurosurgery, Eskişehir Yunus Emre State Hospital, Eskişehir-Turkey.
authors.forename: Çağrı
authors.initials: Ç
authors.lastname: Kökoğlu
authors.forename: Emre
authors.initials: E
authors.lastname: Delen
authors.forename: Ali
authors.initials: A
authors.lastname: Arslantaş
authors.forename: Didem
authors.initials: D
authors.lastname: Arslantaş
authors.forename: Burcu
authors.initials: B
authors.lastname: Kökoğlu
authors.forename: Zühtü
authors.initials: Z
authors.lastname: Özbek
authors.forename: Sema
authors.initials: S
authors.lastname: Uslu
authors.forename: Ahmet Tolgay
authors.initials: AT
authors.lastname: Akıncı
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D004921:Erythropoietin / Q000008:administration & dosage / Q000627:therapeutic use*; D007263:Infusions, Parenteral; D008297:Male; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013119:Spinal Cord Injuries / Q000517:prevention & control*; D000068581:Tadalafil / Q000008:administration & dosage / Q000627:therapeutic use*; D013904:Thoracic Vertebrae
chemical_list: D018696:Neuroprotective Agents; D004921:Erythropoietin; D000068581:Tadalafil