title: CD95 and the MRL-lpr Mouse Model.
abstract: CD95 (Fas-ligand) is a key mediator of cell death in multiple setting, thus its loss within the MRL-lpr (Faslpr) homozygote mice results in spontaneous autoimmunity. This is characterized by the development of arthritis and immune complex glomerulonephrosis making this strain a useful model for studying systemic lupus erythematosus. Herein we describe a method to exploit the heterozygote offspring of this strain in a model to study the effects of a CD95L blocking peptide on lupus-like disease in vivo.
authors.affiliation: Department of Infection Biology, Institute of Infection & Global Health, University of Liverpool, 8 West Derby Street, Liverpool, L69 7BE, UK. Robin.Flynn@liverpool.ac.uk.
authors.forename: Robin J
authors.initials: RJ
authors.lastname: Flynn
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000276:immunology; D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D015551:Autoimmunity / Q000235:genetics; D001947:Breeding; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D016207:Cytokines / Q000096:biosynthesis; D004195:Disease Models, Animal; D053222:Fas Ligand Protein / Q000378:metabolism; D005260:Female; D060005:Genotyping Techniques; D008213:Lymphocyte Activation / Q000235:genetics / Q000276:immunology; D008297:Male; D051379:Mice; D019463:Mice, Inbred MRL lpr; D009928:Organ Specificity / Q000235:genetics / Q000276:immunology; D019014:fas Receptor / Q000235:genetics* / Q000378:metabolism
chemical_list: D001323:Autoantibodies; D016207:Cytokines; D053222:Fas Ligand Protein; D019014:fas Receptor
keywords: CD95L; Fas-L; Faslpr; Kidney damage; Lupus; MRL-lpr; Mouse model of autoimmunity; SLE; T-cell