title: A Synthesis of "Dual Warhead" β-Aryl Ethenesulfonyl Fluorides and One-Pot Reaction to β-Sultams.
abstract: Herein, we report an operationally simple, ligand- and additive-free oxidative boron-Heck coupling that is compatible with the ethenesulfonyl fluoride functional group. The protocol proceeds at room temperature with chemoselectivity and E-isomer selectivity and offers facile access to a wide range of β-aryl/heteroaryl ethenesulfonyl fluorides from commercial boronic acids. Furthermore, we demonstrate a "one-pot click" reaction to directly transform the products to aryl-substituted β-sultams.
authors.affiliation: Catalysis and Peptide Research Unit, University of KwaZulu-Natal , Durban, South Africa.
authors.forename: Praveen K
authors.initials: PK
authors.lastname: Chinthakindi
authors.affiliation: Catalysis and Peptide Research Unit, University of KwaZulu-Natal , Durban, South Africa.
authors.forename: Kimberleigh B
authors.initials: KB
authors.lastname: Govender
authors.affiliation: Catalysis and Peptide Research Unit, University of KwaZulu-Natal , Durban, South Africa.
authors.forename: A Sanjeeva
authors.initials: AS
authors.lastname: Kumar
authors.affiliation: Catalysis and Peptide Research Unit, University of KwaZulu-Natal , Durban, South Africa.
authors.forename: Hendrik G
authors.initials: HG
authors.lastname: Kruger
authors.affiliation: Catalysis and Peptide Research Unit, University of KwaZulu-Natal , Durban, South Africa.
authors.forename: Thavendran
authors.initials: T
authors.lastname: Govender
authors.affiliation: Catalysis and Peptide Research Unit, University of KwaZulu-Natal , Durban, South Africa.
authors.forename: Tricia
authors.initials: T
authors.lastname: Naicker
authors.affiliation: Catalysis and Peptide Research Unit, University of KwaZulu-Natal , Durban, South Africa.|Science for Life Laboratory, Drug Discovery & Development Platform & Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet , Stockholm, Sweden.
authors.forename: Per I
authors.identifier: 0000-0002-9453-6812
authors.initials: PI
authors.lastname: Arvidsson