title: Supramolecular Conjugated Polymer Systems with Controlled Antibacterial Activity.
abstract: Infections of antibiotic-resistant pathogens have caused a series of public health crises across the world. According to the latest published reports, an antibiotic switch has been recognized as a potential strategy to control antibacterial activity for combating this serious drug resistance. Thus, it is anticipated that more effective antibiotic switches should be obtained by further exploring the developed strategies. Here, we report an improved pretreatment strategy using a surfactant (Triton X-100) for constructing an effective supramolecular antibiotic switch based on a poly(fluorene-co-phenylene) derivative (PFP) and cucurbit[7]uril (CB[7]), which can regulate the aggregation state of polymers before the supramolecular self-assembly process occurs. Triton X-100 can regulate the aggregation states of conjugated polymers, which is used to successfully realize the reversible control of bactericidal activity of PFP in the dark and under white light irradiation by supramolecular assembly/disassembly between PFP and CB[7]. Specialized antibiotic switches are significantly important to fight pathogenic infections and solve the drug resistance crisis in the future.
authors.affiliation: Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, P. R. China.
authors.forename: Haotian
authors.initials: H
authors.lastname: Bai
authors.affiliation: Department of Chemistry, Purdue University , West Lafayette, Indiana 47907-2084, United States.
authors.forename: Hongyi
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, P. R. China.
authors.forename: Rong
authors.initials: R
authors.lastname: Hu
authors.affiliation: Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, P. R. China.
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
authors.affiliation: Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, P. R. China.
authors.forename: Fengting
authors.initials: F
authors.lastname: Lv
authors.affiliation: Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, P. R. China.
authors.forename: Libing
authors.initials: L
authors.lastname: Liu
authors.affiliation: Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, P. R. China.
authors.forename: Shu
authors.identifier: 0000-0001-8781-2535
authors.initials: S
authors.lastname: Wang
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D001952:Bridged-Ring Compounds / Q000737:chemistry; D004351:Drug Resistance / Q000187:drug effects; D005449:Fluorenes / Q000737:chemistry; D007093:Imidazoles / Q000737:chemistry; D008958:Models, Molecular; D008968:Molecular Conformation; D011108:Polymers / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils
chemical_list: D000900:Anti-Bacterial Agents; D001952:Bridged-Ring Compounds; D005449:Fluorenes; D007093:Imidazoles; D011108:Polymers; C456276:cucurbit(7)uril; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils; C041509:fluorene