title: Prostate-specific Membrane Antigen-targeted Ligand Positron Emission Tomography/Computed Tomography and Immunohistochemical Findings in a Patient With Synchronous Metastatic Penile and Prostate Cancer.
abstract: A 68-year-old man presented with synchronous metastatic penile and prostate cancer. 68Ga-labeled prostate-specific membrane antigen-targeted ligand positron emission tomography/computed tomography (PSMA-PET/CT) revealed tracer uptake in inguinal, pelvic, and retroperitoneal metastases. Lymph node biopsies and immunohistochemical staining revealed that both cancers involved the lymph nodes and expressed PSMA. In the deposits of penile squamous cell carcinoma, PSMA expression was seen in tumor vessels and may explain the PSMA-PET/CT positivity of inguinal nodes involved in squamous cell carcinoma. The interpretation of imaging in synchronous tumors should take this fact into consideration.
authors.affiliation: Department of Urology, University Hospital "Carl Gustav Carus", Technische Universität Dresden, Dresden, Germany. Electronic address: Michael.Froehner@uniklinikum-dresden.de.
authors.forename: Michael
authors.initials: M
authors.lastname: Froehner
authors.affiliation: Department of Pathology, University Hospital "Carl Gustav Carus", Technische Universität Dresden, Dresden, Germany.
authors.forename: Friederike
authors.initials: F
authors.lastname: Kuithan
authors.affiliation: Department of Nuclear Medicine, University Hospital "Carl Gustav Carus", Technische Universität Dresden, Dresden, Germany.
authors.forename: Klaus
authors.initials: K
authors.lastname: Zöphel
authors.affiliation: Department of Urology, University Hospital "Carl Gustav Carus", Technische Universität Dresden, Dresden, Germany.
authors.forename: Ulrike
authors.initials: U
authors.lastname: Heberling
authors.affiliation: Department of Radiologic Diagnostics, University Hospital "Carl Gustav Carus", Technische Universität Dresden, Dresden, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Laniado
authors.affiliation: Department of Urology, University Hospital "Carl Gustav Carus", Technische Universität Dresden, Dresden, Germany.
authors.forename: Manfred P
authors.initials: MP
authors.lastname: Wirth