title: Strategies to prevent peritoneal carcinomatosis arising from colorectal cancer.
abstract: In the last decades, cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy became a curative option for peritoneal metastases in selected patients, otherwise considered for palliative therapy alone. Better knowledge of physiopathology of peritoneal spread and identification of predictive factors for peritoneal relapse prompted specialized centers to investigate the role of a 'proactive approach' in order to early detect peritoneal metastasis. These encouraging data could justify an active attitude in selected patients at high risk of peritoneal recurrence after curative resection of primary tumor. Selection criteria and the timing of complementary hyperthermic intraperitoneal chemotherapy remain important points of discussion. In this article, we will discuss treatment principles and future perspectives to early treat and, if possible, to prevent peritoneal dissemination after curative treatment of colorectal cancer.
authors.affiliation: Department of Surgical Oncology, Gustave Roussy, Université Paris-Saclay, F-94805 Villejuif, France.
authors.forename: Maximiliano
authors.initials: M
authors.lastname: Gelli
authors.affiliation: Department of Surgical Oncology, Gustave Roussy, Université Paris-Saclay, F-94805 Villejuif, France.
authors.forename: Janina Fl
authors.initials: JF
authors.lastname: Huguenin
authors.affiliation: Department of Surgical Oncology, Gustave Roussy, Université Paris-Saclay, F-94805 Villejuif, France.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Cerebelli
authors.affiliation: Department of Surgical Oncology, Gustave Roussy, Université Paris-Saclay, F-94805 Villejuif, France.
authors.forename: Léonor
authors.initials: L
authors.lastname: Benhaim
authors.affiliation: Department of Surgical Oncology, Gustave Roussy, Université Paris-Saclay, F-94805 Villejuif, France.
authors.forename: Charles
authors.initials: C
authors.lastname: Honoré
authors.affiliation: Department of Surgical Oncology, Gustave Roussy, Université Paris-Saclay, F-94805 Villejuif, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Elias
authors.affiliation: Department of Surgical Oncology, Gustave Roussy, Université Paris-Saclay, F-94805 Villejuif, France.
authors.forename: Diane
authors.initials: D
authors.lastname: Goéré
mesh_terms: D015179:Colorectal Neoplasms / Q000235:genetics / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D003131:Combined Modality Therapy / Q000009:adverse effects / Q000379:methods; D006801:Humans; D064847:Multimodal Imaging; D009367:Neoplasm Staging; D010534:Peritoneal Neoplasms / Q000401:mortality / Q000517:prevention & control* / Q000556:secondary* / Q000628:therapy; D011379:Prognosis; D012307:Risk Factors; D016896:Treatment Outcome
keywords: colorectal cancer; cytoreductive surgery and HIPEC; peritoneal carcinomatosis; peritoneal dissemination; peritoneal metastases; proactive approach; prophylactic HIPEC; second-look surgery with HIPEC