title: [Histologic classification and prognosis factors in phyllodes tumors of breast].
abstract: Objective:To study the relationship between morphological characteristics, grading, diagnosis and prognosis in phyllodes tumors (PT) of the breast.Methods:A retrospective study was carried out on 83 PTs diagnosed between 1999 and 2003 that were classified semi-quantitatively according to the WHO recommendation. Follow-up data was available for some cases, and Cox regression analysis was used to evaluate factors affecting metastasis and recurrence.Results:All cases were classified into the benign (57.8%), borderline (28.9%) and malignant (13.3%). The overall recurrence rate for the 72 cases with follow-up data was 20.8% (15/72), and was 17.5% (7/40) in benign, 22.7% (5/22) in borderline and 3/10 in malignant PT, respectively, with no significant difference (P>0.05). The median interval between the initial diagnosis and the first recurrence was 24 months. Lung or bone metastases occurred in 1/22 borderline and 3/10 malignant PT patients 5 years post-surgery. The mitotic count and the degree of stromal cell atypia were significantly correlated with recurrence (P=0.001 andP=0.006). Multivariate analysis showed that severe stromal cell atypia was an independent predictor of recurrence-free survival in PT [HR=6.40 (95%CI=1.378 to 29.732),P=0.018].Conclusions:Each parameter in the histological grading of PT may have different prognostic value, and markedly increased mitotic count and were predictive of relapse.
authors.affiliation: Department of Pathology, Peking University Health Science Center, Third Hospital of Peking University, Beijing 100191, China.
authors.forename: C
authors.initials: C
authors.lastname: Jia
authors.forename: F
authors.initials: F
authors.lastname: Mei
authors.forename: J Y
authors.initials: JY
authors.lastname: Liu
authors.forename: H M
authors.initials: HM
authors.lastname: Zhao
authors.forename: Y T
authors.initials: YT
authors.lastname: Lei
authors.forename: J
authors.initials: J
authors.lastname: Su
authors.forename: S S
authors.initials: SS
authors.lastname: Huang
authors.forename: J
authors.initials: J
authors.lastname: Zheng
authors.forename: J F
authors.initials: JF
authors.lastname: You
mesh_terms: D001859:Bone Neoplasms / Q000556:secondary; D001943:Breast Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary; D015999:Multivariate Analysis; D060787:Neoplasm Grading; D009364:Neoplasm Recurrence, Local; D003557:Phyllodes Tumor / Q000473:pathology*; D011379:Prognosis; D012044:Regression Analysis; D012189:Retrospective Studies; D017154:Stromal Cells / Q000473:pathology