title: Single-Molecule Force Spectroscopy Quantification of Adhesive Forces in Cucurbit[8]Uril Host-Guest Ternary Complexes.
abstract: Cucurbit[8]uril (CB[8]) heteroternary complexes display certain characteristics making them well-suited for molecular level adhesives. In particular, careful choice of host-guest binding pairs enables specific, fully reversible adhesion. Understanding the effect of the environment is also critical when developing new molecular level adhesives. Here we explore the binding forces involved in the methyl viologen·CB[8]·naphthol heteroternary complex using single-molecule force spectroscopy (SMFS) under a variety of conditions. From SMFS, the interaction of a single ternary complex was found to be in the region of 140 pN. Additionally, a number of surface interactions could be readily differentiated using the SMFS technique allowing for a deeper understanding of the dynamic heteroternary CB[8] system on the single-molecule scale.
authors.affiliation: Melville Laboratory for Polymer Synthesis, Department of Chemistry, University of Cambridge , Lensfield Road, Cambridge, CB2 1EW, United Kingdom.
authors.forename: Zarah
authors.identifier: 0000-0001-8570-045X
authors.initials: Z
authors.lastname: Walsh-Korb
authors.affiliation: Department of Chemistry, Tsinghua University , Beijing 100084, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Yu
authors.affiliation: Melville Laboratory for Polymer Synthesis, Department of Chemistry, University of Cambridge , Lensfield Road, Cambridge, CB2 1EW, United Kingdom.
authors.forename: Emma-Rose
authors.initials: ER
authors.lastname: Janeček
authors.affiliation: Melville Laboratory for Polymer Synthesis, Department of Chemistry, University of Cambridge , Lensfield Road, Cambridge, CB2 1EW, United Kingdom.
authors.forename: Yang
authors.initials: Y
authors.lastname: Lan
authors.affiliation: Melville Laboratory for Polymer Synthesis, Department of Chemistry, University of Cambridge , Lensfield Road, Cambridge, CB2 1EW, United Kingdom.
authors.forename: Jesús
authors.identifier: 0000-0002-5380-6863
authors.initials: J
authors.lastname: Del Barrio
authors.affiliation: Melville Laboratory for Polymer Synthesis, Department of Chemistry, University of Cambridge , Lensfield Road, Cambridge, CB2 1EW, United Kingdom.
authors.forename: Paul E
authors.initials: PE
authors.lastname: Williams
authors.affiliation: Department of Chemistry, Tsinghua University , Beijing 100084, China.
authors.forename: Xi
authors.identifier: 0000-0002-4823-9120
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Melville Laboratory for Polymer Synthesis, Department of Chemistry, University of Cambridge , Lensfield Road, Cambridge, CB2 1EW, United Kingdom.
authors.forename: Oren A
authors.identifier: 0000-0001-8032-7166
authors.initials: OA
authors.lastname: Scherman