title: Prognostic value of the seventh AJCC/UICC TNM classification of intestinal-type ethmoid adenocarcinoma: Systematic review and risk prediction model.
abstract: The purpose of this study was to propose a prognostic classification of intestinal-type adenocarcinoma (ITAC) based on literature search and prognostic modeling of cohort data.
  
  
  
  We first conducted a literature search to assess the homogeneity of the reported estimates of 5-year survival and to identify the influence of T classification. We then pooled prospective data from 3 large French and Italian series to predict time to all-cause mortality. The sample was randomly split to derive and then to validate the proposed prognostic model.
  
  
  
  Literature analysis confirmed the heterogeneity in 5-year survival rates, partly explained in subsets of homogeneous T-values. The sample included 223 patients, randomly separated into a derivation (n = 141) and a validation set (n = 82). Invasion of the sphenoid lateral and/or posterior walls and dura/cerebral invasion were systematically associated with a poor survival.
  
  
  
  The incorporation of the invasion of the sphenoid lateral or posterior walls should be considered for ITAC management and prognostication. © 2017 Wiley Periodicals, Inc. Head Neck 39: 668-678, 2017.
authors.affiliation: Ear, Nose, and Throat Department, Lariboisière University Hospital, Paris, France.
authors.forename: Domitille
authors.initials: D
authors.lastname: Fiaux-Camous
authors.affiliation: Biostatistics and Clinical Epidemiology (ECSTRA) Team, UMR 1153 Inserm, Paris Diderot University, Saint-Louis Hospital, AP-HP, Paris, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Chevret
authors.affiliation: Ear, Nose, and Throat Department, Lariboisière University Hospital, Paris, France.
authors.forename: Natalie
authors.initials: N
authors.lastname: Oker
authors.affiliation: Department of Otorhinolaryngology, Insubria University, Varese, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Turri-Zanoni
authors.affiliation: Department of Otorhinolaryngology, University of Brescia, Brescia, Italy.
authors.forename: Davide
authors.initials: D
authors.lastname: Lombardi
authors.affiliation: Ear, Nose, and Throat Department, Rouen University Hospital, Rouen, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Choussy
authors.affiliation: Department of Radiation Oncology, Ghent University Hospital, Ghent, Belgium.
authors.forename: Frederic
authors.initials: F
authors.lastname: Duprez
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, University Hospitals Leuven, Leuven, Belgium.
authors.forename: Marc
authors.initials: M
authors.lastname: Jorissen
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Bordeaux, F-X Michelet Center, Bordeaux Cedex, France.
authors.forename: Ludovic
authors.initials: L
authors.lastname: de Gabory
authors.affiliation: Ear, Nose, and Throat Department, CHU Hôtel-Dieu, Nantes, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Malard
authors.affiliation: Ear, Nose, and Throat Department, Lariboisière University Hospital, Paris, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Herman
authors.affiliation: Department of Otorhinolaryngology, University of Brescia, Brescia, Italy.
authors.forename: Piero
authors.initials: P
authors.lastname: Nicolai
authors.affiliation: Department of Otorhinolaryngology, Insubria University, Varese, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Castelnuovo
authors.affiliation: Ear, Nose, and Throat Department, Lariboisière University Hospital, Paris, France.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Verillaud
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology*; D002423:Cause of Death; D018572:Disease-Free Survival; D005004:Ethmoid Bone / Q000473:pathology*; D005260:Female; D006801:Humans; D007414:Intestinal Neoplasms / Q000401:mortality / Q000473:pathology; D008297:Male; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D011379:Prognosis; D012888:Skull Neoplasms / Q000401:mortality / Q000473:pathology*; D016019:Survival Analysis
keywords: TNM classification; adenocarcinoma; endoscopic resection with transnasal craniectomy; ethmoid; intestinal-type adenocarcinoma (ITAC)