title: Longitudinal multi-modal neuroimaging in opsoclonus-myoclonus syndrome.
abstract: To investigate structural, metabolic, and functional connectivity changes in visual and oculomotor structures in a patient with paraneoplastic opsoclonus-myoclonus syndrome, serial resting-state functional and structural MRI, and FDG-PET data were collected during the acute stage and later on when the opsoclonus had resolved. In the acute stage, an FDG-PET scan demonstrated a substantially increased metabolism in structures around the deep cerebellar nuclei [e.g., fastigial nucleus (FN)] and a relatively reduced metabolism in the bilateral occipital lobes which normalized over 12 months. Functional connectivity increased initially between the seeds of the oculomotor and visual systems, including the primary and motion-sensitive visual cortex, frontal eye fields, superior colliculus, and cerebellar oculomotor vermis (OMV), and then decreased in the chronic stage as the symptoms resolved. The functional connectivity between the OMV and FN showed a positive correlation during the acute stage, which decreased later on. We provide a descriptive presentation of the changes of abnormal functional connectivity throughout visuo-oculomotor brain areas during opsoclonus and suggest directions for further research on the pathogenesis of opsoclonus.
authors.affiliation: Department of Neurology, Chonbuk National University Hospital, School of Medicine, 20 Geonji-ro, Deokjin-gu, Jeonju-City, Chonbuk, 561-712, Korea. ohsun@jbnu.ac.kr.|Research Institute of Clinical Medicine, Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Korea. ohsun@jbnu.ac.kr.|Department of Neurology, Ludwig-Maximilians-University, Munich, Germany. ohsun@jbnu.ac.kr.
authors.forename: Sun-Young
authors.initials: SY
authors.lastname: Oh
authors.affiliation: Graduate School of Systemic Neuroscience, Ludwig-Maximilians University, Munich, Germany.|German Center for Vertigo and Balance Disorders, Ludwig-Maximilians University, Munich, Germany.
authors.forename: Rainer
authors.initials: R
authors.lastname: Boegle
authors.affiliation: Department of Neurology, Ludwig-Maximilians-University, Munich, Germany.|Graduate School of Systemic Neuroscience, Ludwig-Maximilians University, Munich, Germany.
authors.forename: Peter Zu
authors.initials: PZ
authors.lastname: Eulenburg
authors.affiliation: Department of Neurology, Ludwig-Maximilians-University, Munich, Germany.|Graduate School of Systemic Neuroscience, Ludwig-Maximilians University, Munich, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Ertl
authors.affiliation: Department of Neurology, Seoul National University School of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
authors.forename: Ji-Soo
authors.initials: JS
authors.lastname: Kim
authors.affiliation: Department of Neurology, Ludwig-Maximilians-University, Munich, Germany.|Graduate School of Systemic Neuroscience, Ludwig-Maximilians University, Munich, Germany.|German Center for Vertigo and Balance Disorders, Ludwig-Maximilians University, Munich, Germany.|Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
authors.forename: Marianne
authors.initials: M
authors.lastname: Dieterich
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D001931:Brain Mapping; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging / Q000379:methods; D064847:Multimodal Imaging / Q000379:methods; D009434:Neural Pathways / Q000000981:diagnostic imaging / Q000503:physiopathology; D053578:Opsoclonus-Myoclonus Syndrome / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D049268:Positron-Emission Tomography / Q000379:methods; D019275:Radiopharmaceuticals; D012146:Rest; D055815:Young Adult
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: FDG-PET; Functional connectivity; Opsoclonus; Reciprocal inhibition; Resting-state functional magnetic resonance imaging (rs-fMRI); Saccades