title: Sketching of CD95 Oligomers by In Silico Investigations.
abstract: This work aimed at building a 3D model of trimeric apo CD95. By combining different molecular modeling approaches and experimental information, we have been able to obtain a consensual organization of the complex. Our strategy permitted the construction of a plausible trimer, and to sketch the interface between protomers. The final model will guide further experimental investigations and understanding of CD95 structure and functions.
authors.affiliation: Bioprojet-Biotech, 4 rue du Chesnay Beauregard, 5762, Saint Gregoire, France. n.levoin@bioprojet.com.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Levoin
mesh_terms: D000595:Amino Acid Sequence; D003198:Computer Simulation; D030562:Databases, Protein; D006801:Humans; D008958:Models, Molecular; D056004:Molecular Dynamics Simulation; D011487:Protein Conformation; D055503:Protein Multimerization; D012984:Software; D064878:Web Browser; D019014:fas Receptor / Q000737:chemistry* / Q000378:metabolism
chemical_list: D019014:fas Receptor
keywords: CD95; Fas; Homooligomer; Model building; Protein model; Trimer