title: Common Therapeutic Modalities Against Diabetes and Associated Cardiovascular Disease.
abstract: Despite recent advances in medical research, the incidence of diabetes and cardiovascular disease (CVD)-induced fatal events is increasing. The literature point towards several co-occurring pathways that could lead to terminal complications related with these diseases. Different pathophysiological alterations such as hyperglycaemia, hyperinsulinaemia, insulin resistance, obesity, endothelial dysfunction and oxidative stress lead to the initiation and progression of atherosclerotic plaques. In view of the continuous rise in fatal events and overlapping pathological conditions associated with CVD and diabetes, there is a critical need to develop a common treatments against these diseases. The present review highlights the possible use of common drugs that could target diabetes and associated CVD.
authors.affiliation: King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589. Saudi Arabia.
authors.forename: Nasimudeen R
authors.initials: NR
authors.lastname: Jabir
authors.affiliation: King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589. Saudi Arabia.
authors.forename: Chelapram Kandy
authors.initials: CK
authors.lastname: Firoz
authors.affiliation: King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589. Saudi Arabia.
authors.forename: Ghulam Md
authors.initials: GM
authors.lastname: Ashraf
authors.affiliation: Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, 21589. Saudi Arabia.
authors.forename: Syed Kashif
authors.initials: SK
authors.lastname: Zaidi
authors.affiliation: Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, 21589. Saudi Arabia.
authors.forename: Shazi
authors.initials: S
authors.lastname: Shakil
authors.affiliation: Novel Global Community Educational Foundation, 7 Peterlee Place, Hebersham, NSW. Australia.
authors.forename: Mohammad Amjad
authors.initials: MA
authors.lastname: Kamal
authors.affiliation: King Fahd Medical Research Center, King Abdulaziz University, P. O. Box 80216, Jeddah 21589. Saudi Arabia.
authors.forename: Shams
authors.initials: S
authors.lastname: Tabrez
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D048909:Diabetes Complications / Q000188:drug therapy; D003920:Diabetes Mellitus / Q000188:drug therapy*; D058065:Diabetic Cardiomyopathies / Q000188:drug therapy*; D006801:Humans
chemical_list: D001786:Blood Glucose
keywords: Cardiovascular disease; diabetes mellitus; glycaemic imbalance; obesity; oxidative stress