title: Risk Factors for Recurrence After Laparoscopic Ventral Rectopexy.
abstract: BACKGROUND
  Laparoscopic ventral rectopexy effectively treats posterior compartment prolapse. However, recurrence after laparoscopic ventral rectopexy is poorly understood.
  
  
  OBJECTIVE
  This study aimed to evaluate factors contributing to recurrence after laparoscopic ventral rectopexy.
  
  
  METHODS
  A retrospective cohort analysis was performed of patients who underwent laparoscopic ventral rectopexy between June 2008 and June 2014. Patients presenting with full-thickness rectal prolapse were compared against the rest. Cox proportional hazards regression was used to determine predictors for recurrence. Operative findings of redo cases were evaluated.
  
  
  METHODS
  This study was conducted under the supervision of a single pelvic floor surgeon.
  
  
  METHODS
  A total of 231 patients with a median follow-up of 47 months were included.
  
  
  METHODS
  Clinicopathological risk factors and technical failures contributing to recurrence were analyzed.
  
  
  RESULTS
  The overall recurrence rate was 11.7% (n = 27). Twenty-five recurrences occurred in patients with full-thickness rectal prolapse, of which 16 were full-thickness recurrences (14.2% (16/113)). Multivariate analyses showed predictors for recurrence to be prolonged pudendal nerve terminal motor latency (HR = 5.57 (95% CI, 1.13 - 27.42); p = 0.04) and the use of synthetic mesh as compared with biologic grafts (HR = 4.24 (95% CI, 1.27-14.20); p = 0.02). Age >70 years and poorer preoperative continence were also associated with recurrence on univariate analysis. Technical failures contributing to recurrence included mesh detachment from the sacral promontory and inadequate midrectal mesh fixation.
  
  
  CONCLUSIONS
  Modifications to the operative technique were made throughout the study period. A postoperative defecating proctogram was not routinely performed.
  
  
  CONCLUSIONS
  Recurrence after laparoscopic ventral rectopexy is multifactorial, and risk factors are both clinical and technical. The use of biologic grafts was associated with lower recurrence as compared with synthetic mesh. Patients with full-thickness rectal prolapse who are elderly, have poorer baseline continence, and have prolonged pudendal nerve terminal motor latency are at increased risk of recurrence.
authors.affiliation: 1 Department of Colorectal Surgery, Singapore General Hospital, Singapore 2 Department of Colorectal Surgery, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia 3 Faculty of Medicine and Biomedical Sciences, University of Queensland, Brisbane, Queensland, Australia.
authors.forename: Cherylin W P
authors.initials: CW
authors.lastname: Fu
authors.forename: Andrew R L
authors.initials: AR
authors.lastname: Stevenson
mesh_terms: D000367:Age Factors; D000368:Aged; D013505:Digestive System Surgical Procedures; D005242:Fecal Incontinence / Q000503:physiopathology; D005260:Female; D006801:Humans; D007443:Intussusception / Q000601:surgery*; D010535:Laparoscopy; D008875:Middle Aged; D015999:Multivariate Analysis; D016016:Proportional Hazards Models; D060525:Pudendal Nerve / Q000503:physiopathology; D012002:Rectal Diseases / Q000601:surgery; D012005:Rectal Prolapse / Q000503:physiopathology / Q000601:surgery*; D020047:Rectocele / Q000601:surgery*; D012008:Recurrence; D012086:Reoperation; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D013526:Surgical Mesh / Q000706:statistics & numerical data; D016896:Treatment Outcome