title: High predictability of impaired glucose tolerance by combining cardiometabolic screening parameters in obese children.
abstract: BACKGROUND
  There is debate on which overweight and obese children should be screened for the presence of impaired glucose tolerance (IGT) by oral glucose tolerance testing (OGTT). The objective of the study was to identify risk factors predictive of the presence of IGT.
  
  
  METHODS
  In a cohort of overweight children, who underwent OGTT, we determined the association of anthropometric and laboratory parameters with IGT and whether combining parameters improved the sensitivity of screening for IGT.
  
  
  RESULTS
  Out of 145 patients, IGT was present in 11, of whom two had impaired fasting glucose (IFG). Elevated blood pressure (p=0.025) and elevated liver enzymes (p=0.003) were associated with IGT, whereas IFG was not (p=0.067), screening patients with either one of these parameters predicted IGT with a high sensitivity of 1.00, and a number needed to screen of 5.7.
  
  
  CONCLUSIONS
  Screening all patients with either IFG, presence of elevated blood pressure and elevated liver enzymes, significantly increases predictability of IGT compared to using IFG alone.
authors.forename: Cornelis Jan de
authors.initials: CJ
authors.lastname: Groot
authors.forename: Jeroen van der
authors.initials: JV
authors.lastname: Grond
authors.forename: Yosine
authors.initials: Y
authors.lastname: Delgado
authors.forename: Edmond H H M
authors.initials: EH
authors.lastname: Rings
authors.forename: Sabine E
authors.initials: SE
authors.lastname: Hannema
authors.forename: Erica L T
authors.initials: EL
authors.lastname: van den Akker
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood*; D001786:Blood Glucose / Q000032:analysis; D002318:Cardiovascular Diseases / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D018149:Glucose Intolerance / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D005951:Glucose Tolerance Test; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D009765:Obesity / Q000150:complications* / Q000503:physiopathology; D050177:Overweight / Q000150:complications; D011236:Prediabetic State / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D011379:Prognosis; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D001786:Blood Glucose