title: Fine Particulate Constituents and Lung Dysfunction: A Time-Series Panel Study.
abstract: The evidence is quite limited regarding the constituents of fine particulate matter (PM2.5) responsible for lung dysfunction. We designed a time-series panel study in 28 patients to examine the effects of 10 major constituents of PM2.5on lung function with repeated daily measurements from December 2012 to May 2013 in Shanghai, China. We applied a linear mixed-effect model combined with a distributed lag model to estimate the cumulative effects of PM2.5constituents on morning/evening forced expiratory volume in 1-s (FEV1) and peak expiratory flow (PEF) over a week. The cumulative decreases in morning FEV1, evening FEV1, morning PEF and evening PEF associated with an interquartile range (35.8 μg/m3) increase in PM2.5concentrations were 33.49 [95% confidence interval(CI):2.45,54.53] mL, 16.80 (95%CI:3.75,29.86) mL, 4.48 (95%CI:2.30,6.66) L/min, and 1.31 (95%CI:-0.85,3.47) L/min, respectively. These results were not substantially changed after adjusting for gases in two-pollutant models. The associations of elemental carbon (EC) and nitrates with morning/evening FEV1, and the associations of EC and sulfates with morning PEF were robust after controlling for PM2.5.This study demonstrated that short-term exposure to PM2.5was associated with reduced pulmonary function. Some constituents (EC, sulfate and nitrate) may be responsible for the detrimental effects.
authors.affiliation: Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University , Shanghai 200032, China.
authors.forename: Shujing
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University , Shanghai 200032, China.
authors.forename: Yutong
authors.initials: Y
authors.lastname: Gu
authors.affiliation: State Environmental Protection Key Laboratory of the Formation and Prevention of Urban Air Pollution Complex, Shanghai Academy of Environmental Sciences , Shanghai 200233, China.
authors.forename: Liping
authors.initials: L
authors.lastname: Qiao
authors.affiliation: School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and Key Lab of Health Technology Assessment of the Ministry of Health, Fudan University , Shanghai 200032, China.
authors.forename: Cuicui
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University , Shanghai 200032, China.
authors.forename: Yuanlin
authors.initials: Y
authors.lastname: Song
authors.affiliation: Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University , Shanghai 200032, China.
authors.forename: Chunxue
authors.initials: C
authors.lastname: Bai
authors.affiliation: Medical Department, Zhongshan Hospital, Fudan University , Shanghai 200032, China.
authors.forename: Yuchun
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University , Shanghai 200032, China.
authors.forename: Haiying
authors.initials: H
authors.lastname: Ji
authors.affiliation: State Environmental Protection Key Laboratory of the Formation and Prevention of Urban Air Pollution Complex, Shanghai Academy of Environmental Sciences , Shanghai 200233, China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhou
authors.affiliation: State Environmental Protection Key Laboratory of the Formation and Prevention of Urban Air Pollution Complex, Shanghai Academy of Environmental Sciences , Shanghai 200233, China.
authors.forename: Hongli
authors.initials: H
authors.lastname: Wang
authors.affiliation: School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and Key Lab of Health Technology Assessment of the Ministry of Health, Fudan University , Shanghai 200032, China.|Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP3), Fudan University , Shanghai 200433, China.
authors.forename: Renjie
authors.initials: R
authors.lastname: Chen
authors.affiliation: School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and Key Lab of Health Technology Assessment of the Ministry of Health, Fudan University , Shanghai 200032, China.|Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP3), Fudan University , Shanghai 200433, China.
authors.forename: Haidong
authors.identifier: 0000-0002-1871-8999
authors.initials: H
authors.lastname: Kan
mesh_terms: D000393:Air Pollutants / Q000494:pharmacology*; D002681:China; D005541:Forced Expiratory Volume; D006801:Humans; D008168:Lung / Q000187:drug effects; D052638:Particulate Matter
chemical_list: D000393:Air Pollutants; D052638:Particulate Matter