title: A Case-Control Association Study ofRANTES (-28C>G)Polymorphism as a Risk Factor for Parkinson's Disease in Isparta, Turkey.
abstract: Background. Recent studies have revealed that inflammatory processes are involved in the pathogenesis of Parkinson's disease (PD). Multiple lines of evidence have suggested that chemokines and their receptors are involved in several neurodegenerative disorders. We have examined whether genetic polymorphisms at the genes encoding chemokinesIL-8 (-251A>T), MCP-1 (-2518A/G), andRANTES (-28C>G)and chemokine receptorsCCR2 (V64I) andCCR5 (-Δ32)were associated with sporadic PD risk in Isparta, Turkey.Method. The pilot case-control association study included 30 PD patients and 60 control subjects, who were all genotyped with PCR-RFLP for the five polymorphisms. Their genotype and haplotype frequencies were compared statistically.Results. One SNP(-28C>G)inRANTESrevealed a significant association with PD (P(allele) < 0.0001,p-trend = 0.0007). The risk allele(G)in the homozygous and dominant models (OR = 17.29 and 32.10, 95% CI = 0.86-347.24 and 1.74-591.937, resp.) suggests additional PD risk. The haplotypeTGCANfrom theIL-8 (-251A>T), MCP-1 (-2518A>G), RANTES (-28C>G), CCR-2 (V64I), andCCR-5 (-Δ32)has protective effect (OR = 0.08 [CI = 0.01-0.63],p= 0.019).Conclusions. Our data are the first indication of the role ofRANTES (-28C>G)in PD risk.
authors.affiliation: Department of Medical Biology, Faculty of Medicine, Süleyman Demirel University, Isparta, Turkey.
authors.forename: Nilufer
authors.identifier: 0000-0002-7376-1607
authors.initials: N
authors.lastname: Sahin-Calapoglu
authors.affiliation: Department of Neurology, Faculty of Medicine, Süleyman Demirel University, Isparta, Turkey.
authors.forename: Serpil
authors.initials: S
authors.lastname: Demirci
authors.affiliation: Department of Biochemistry, Faculty of Science, Süleyman Demirel University, Isparta, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Calapoglu
authors.affiliation: Department of Medical Biology, Faculty of Medicine, Süleyman Demirel University, Isparta, Turkey.
authors.forename: Baris
authors.initials: B
authors.lastname: Yasar