title: Panax Notoginseng Saponin Controls IL-17 Expression in Helper T Cells.
abstract: Panax Notoginseng, a traditional Chinese medicine, is known as an anti-inflammatory herb. However, the molecular mechanism by which it controls helper T cell mediated immune responses is largely unknown.
  
  
  
  Naive CD4+T cells isolated from healthy donors, patients with Behcet's disease, and C57BL/6 mice were polarized into Th1, Th17, and Treg cells. Proliferation and cytokine expression were measured in these cells with the presence or absence of Panax Notoginseng saponins (PNS). Genomewide expression profiles of Th1, Th17, and Treg cells were assessed using Affymetrix microarray analysis.
  
  
  
  We found that PNS control the proliferation and differentiation of Th17 cells by globally downregulating the expression of inflammatory cytokines and cell cycle genes.
  
  
  
  These findings demonstrated that PNS function as an anti-inflammatory agent through directly targeting Th17 cell mediated immune response.
authors.affiliation: 1 State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University , Guangzhou, China .|2 Guangdong Province Key Laboratory of Brain Function and Disease, Sun Yat-sen University , Guangzhou, China .
authors.forename: Jia-Ru
authors.initials: JR
authors.lastname: Wei
authors.affiliation: 1 State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University , Guangzhou, China .|2 Guangdong Province Key Laboratory of Brain Function and Disease, Sun Yat-sen University , Guangzhou, China .
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Wen
authors.affiliation: 1 State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University , Guangzhou, China .
authors.forename: Paul W
authors.initials: PW
authors.lastname: Bible
authors.affiliation: 3 Laboratory of Immunology, National Eye Institute, National Institutes of Health , Bethesda, Maryland.
authors.forename: Zhiyu
authors.initials: Z
authors.lastname: Li
authors.affiliation: 3 Laboratory of Immunology, National Eye Institute, National Institutes of Health , Bethesda, Maryland.
authors.forename: Robert B
authors.initials: RB
authors.lastname: Nussenblatt
authors.affiliation: 1 State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University , Guangzhou, China .|2 Guangdong Province Key Laboratory of Brain Function and Disease, Sun Yat-sen University , Guangzhou, China .|3 Laboratory of Immunology, National Eye Institute, National Institutes of Health , Bethesda, Maryland.
authors.forename: Lai
authors.initials: L
authors.lastname: Wei
mesh_terms: D000818:Animals; D001528:Behcet Syndrome / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D020381:Interleukin-17 / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000276:immunology; D051379:Mice; D020411:Oligonucleotide Array Sequence Analysis; D053723:Panax notoginseng / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006377:T-Lymphocytes, Helper-Inducer / Q000187:drug effects* / Q000276:immunology
chemical_list: D020381:Interleukin-17; D012503:Saponins
keywords: Behcet's disease; CD4+ T cells; Panax Notoginseng saponin; Th17