title: Identification of early neurodegenerative change in presymptomatic spinocerebellar ataxia type 1: A diffusion tensor imaging study.
abstract: We report a 41-year-old man of presymptomatic spinocerebellar ataxia type 1. Diffusion tensor imaging (DTI) verified decreased fractional anisotropy of cerebellar afferent and efferent pathways compared to 5 age-matched healthy controls while conventional MRI revealed normal brain. DTI was valuable in detection of early microstructural damage of cerebellar pathways.
authors.affiliation: Department of Rehabilitation Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-Gu, Seoul, 06591, Republic of Korea. Electronic address: nugry@naver.com.
authors.forename: Yeon Ji
authors.initials: YJ
authors.lastname: Yoo
authors.affiliation: Department of Rehabilitation Medicine, Graduate School, The Catholic University of Korea, 222 Banpo-daero, Seocho-Gu, Seoul, 06591, Republic of Korea. Electronic address: jeehaeoh@gmail.com.
authors.forename: Jeehae
authors.initials: J
authors.lastname: Oh
mesh_terms: D000328:Adult; D056324:Diffusion Tensor Imaging / Q000379:methods; D006801:Humans; D008297:Male; D019636:Neurodegenerative Diseases / Q000000981:diagnostic imaging / Q000235:genetics; D020754:Spinocerebellar Ataxias / Q000000981:diagnostic imaging* / Q000235:genetics
keywords: Diffusion tensor imaging; Spinocerebellar ataxia