title: The pathogenesis of ANCA-associated vasculitis.
abstract: ANCA-associated vasculitis is characterized by the presence of anti-neutrophil cytoplasmic antibody (ANCA) in the serum. ANCA is a pathogenic autoantibody as well as the disease marker. It has been realized that ANCA-cytokine sequence is involved in the pathogenesis of ANCA-associated vasculitis. Recent studies have revealed that neutrophil extracellular traps induced by ANCA are also involved in the pathogenesis. In this study, we review the roles of neutrophils, eosinophils, macrophages/dendritic cells, complements, B cells/plasma cells, T cells, and cytokines/chemokines/cell growth factors in the pathogenesis of ANCA-associated vasculitis.
authors.affiliation: Faculty of Health Sciences, Hokkaido University.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Ishizu
mesh_terms: D000818:Animals; D056648:Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / Q000209:etiology* / Q000473:pathology; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000009:adverse effects*; D001402:B-Lymphocytes / Q000276:immunology; D018925:Chemokines; D003165:Complement System Proteins / Q000276:immunology; D016207:Cytokines; D003713:Dendritic Cells / Q000276:immunology; D004804:Eosinophils; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D008264:Macrophages / Q000276:immunology / Q000502:physiology; D051379:Mice; D009504:Neutrophils / Q000276:immunology / Q000473:pathology; D010950:Plasma Cells / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D018925:Chemokines; D016207:Cytokines; D036341:Intercellular Signaling Peptides and Proteins; D003165:Complement System Proteins