title: In vivo sedative and hypnotic activities of methanol extract from the leaves of Jacquemontia paniculata (Burm.f.) Hallier f. in Swiss Albino mice.
abstract: BACKGROUND
  The superior genus Jacquemontia belongs to Convolvulaceae, with around 120 species, and is also considered taxonomically difficult. The aim of this experiment was to assess the sedative and hypnotic activities of methanol extract from the leaves of Jacquemontia paniculata (Burm.f.) Hallier f.
  
  
  METHODS
  The sedative and hypnotic activities were evaluated by hole-cross, open field, hole-board, elevated plus maze (EPM), and thiopental sodium-induced sleeping time determination tests in mice at doses of 200 and 400 mg/kg.
  
  
  RESULTS
  In this investigation, we found that methanol extract of Jacquemontia paniculata (MEJP) produced a significant dose-dependent inhibition of spontaneous activity of mice both in hole-cross and open field tests. In addition, it also decreased the number of head dips in hole-board test. In the case of EPM test, this crude extract induced an anxiogenic-like effect rather than anxiolytic effect in mice. Moreover, MEJP significantly decreased the induction time to sleep and prolonged the duration of sleeping, induced by thiopental sodium.
  
  
  CONCLUSIONS
  To conclude, these results suggest that the MEJP leaves possess potent sedative and hypnotic activities, which supported its therapeutic use for sleep disorders like insomnia.
authors.forename: Md
authors.initials: M
authors.lastname: Jakaria
authors.forename: Chayan Dhar
authors.initials: CD
authors.lastname: Clinton
authors.forename: Mukimul
authors.initials: M
authors.lastname: Islam
authors.forename: Mohammad Belal
authors.initials: MB
authors.lastname: Talukder
authors.forename: Md
authors.initials: M
authors.lastname: Shariful Islam
authors.forename: Syed Mohammed
authors.initials: SM
authors.lastname: Tareq
authors.forename: Shaikh Bokhtear
authors.initials: SB
authors.lastname: Uddin
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000302:isolation & purification / Q000494:pharmacology*; D027722:Convolvulaceae; D005106:Exploratory Behavior / Q000187:drug effects* / Q000502:physiology; D006993:Hypnotics and Sedatives / Q000302:isolation & purification / Q000494:pharmacology*; D008124:Locomotion / Q000187:drug effects / Q000502:physiology; D008297:Male; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology; D000432:Methanol / Q000494:pharmacology; D051379:Mice; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves
chemical_list: D014151:Anti-Anxiety Agents; D006993:Hypnotics and Sedatives; D010936:Plant Extracts; D000432:Methanol