title: Sleep-disordered breathing is associated with higher carboxymethyllysine level in elderly women but not elderly men in the cardiovascular health study.
abstract: BACKGROUND
  Carboxymethyl-lysine (CML) results from oxidative stress and has been linked to cardiovascular disease.
  
  
  OBJECTIVE
  The objective of this study is to investigate the association between sleep-disordered breathing (SDB) - a source of oxidative stress - and CML.
  
  
  METHODS
  About 1002 participants in the Cardiovascular Health Study (CHS) were studied.
  
  
  RESULTS
  Women with SDB had significantly higher CML concentration compared with those without SDB (OR = 1.63, 95%CI = 1.03-2.58, p = 0.04). The association was not significant among men.
  
  
  CONCLUSIONS
  SDB was associated with CML concentration among elderly women but not men in the Cardiovascular Health Study.
  
  
  CONCLUSIONS
  Accumulation of CML may be an adverse health consequence of SDB.
authors.affiliation: a Department of Public Health, Campbell University College of Pharmacy and Health Sciences , Campbell University , Buies Creek , NC , United States.
authors.forename: Peter D
authors.initials: PD
authors.lastname: Ahiawodzi
authors.affiliation: b Department of Epidemiology & Population Health, School of Public Health and Information Sciences , University of Louisville , Louisville , KY , United States.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Kerber
authors.affiliation: b Department of Epidemiology & Population Health, School of Public Health and Information Sciences , University of Louisville , Louisville , KY , United States.
authors.forename: Kira C
authors.initials: KC
authors.lastname: Taylor
authors.affiliation: b Department of Epidemiology & Population Health, School of Public Health and Information Sciences , University of Louisville , Louisville , KY , United States.
authors.forename: Frank D
authors.initials: FD
authors.lastname: Groves
authors.affiliation: b Department of Epidemiology & Population Health, School of Public Health and Information Sciences , University of Louisville , Louisville , KY , United States.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: O'Brien
authors.affiliation: c Department of Medicine and Family and Preventive Medicine , University of California San Diego , La Jolla , United States.
authors.forename: Joachim H
authors.initials: JH
authors.lastname: Ix
authors.affiliation: d Department of Epidemiology and Population Health , Yeshiva University Albert Einstein College of Medicine , Bronx , United States.
authors.forename: Jorge R
authors.initials: JR
authors.lastname: Kizer
authors.affiliation: e Harvard Medical School , Boston , United States.
authors.forename: Luc
authors.initials: L
authors.lastname: Djoussé
authors.affiliation: f Departments of Pathology and Biochemistry , University of Vermont College of Medicine , Burlington , United States.
authors.forename: Russell P
authors.initials: RP
authors.lastname: Tracy
authors.affiliation: g Department of Geriatric Medicine , University of Pittsburgh , Pittsburgh , United States.
authors.forename: Anne B
authors.initials: AB
authors.lastname: Newman
authors.affiliation: h Senior Vice President for Research, New York Academy of Medicine , New York , United States.
authors.forename: David S
authors.initials: DS
authors.lastname: Siscovick
authors.affiliation: i Deparment of Internal Medicine , University of California Berkeley , Berkeley , United States.
authors.forename: John
authors.initials: J
authors.lastname: Robbins
authors.affiliation: j Deparment of General Medicine and Primary Care , Beth Israel Deaconess Medical Center , Boston , United States.
authors.forename: Kenneth
authors.initials: K
authors.lastname: Mukamal
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002318:Cardiovascular Diseases / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008239:Lysine / Q000031:analogs & derivatives* / Q000097:blood; D008297:Male; D018384:Oxidative Stress; D012737:Sex Factors; D012891:Sleep Apnea Syndromes / Q000097:blood*
chemical_list: C048496:N(6)-carboxymethyllysine; D008239:Lysine
keywords: Apnea–Hypopnea Index; Carboxymethyl-lysine; advanced glycation end-product; oxidative stress; sleep-disordered breathing