title: Increased erythrocyte aggregation and oxidative stress in patients with idiopathic interstitial pneumonia.
abstract: BACKGROUND
  Hemorheological properties are important determinants of tissue oxygenation. Although hemorheological alterations in various lung diseases have been well-defined, no information is available about the effects of idiopathic interstitial pneumonia (IIP) on hemorheological parameters.
  
  
  OBJECTIVE
  The aim of this study was to investigate hemorheological parameters (erythrocyte deformability, aggregation, and plasma viscosity -PV) and associated oxidative stress indices in patients with IIP.
  
  
  METHODS
  The study enrolled 31 patients (9 Idiopathic pulmonary fibrosis (IPF), 10 non-specific Interstitial Pneumonia (NSIP), 12 Cryptogenic Organising Pneumonia (COP) and 33 healthy controls. Erythrocyte deformability and aggregation were measured by an ektacytometer. PV was determined by a cone-plate rotational viscometer and oxidative stress via a commercial kit.
  
  
  RESULTS
  Erythrocyte aggregation, total oxidant status (TOS) and oxidative stress index (OSI) of IIP patients were higher than controls whereas erythrocyte deformability, PV and total antioxidant status (TAS) were unaltered.
  
  
  CONCLUSIONS
  Increment of oxidative stress in IIP seems to depend on enhancement of oxidants, rather than alteration of antioxidants. The issue that, elevated erythrocyte aggregation may further impair tissue oxygenation by disturbing microcirculation in IIP, may be considered in the follow up and development of new treatment protocols for this disease.
authors.affiliation: Pamukkale University. drerhanugurlu@gmail.com.
authors.forename: Erhan
authors.initials: E
authors.lastname: Ugurlu
authors.forename: Emine
authors.initials: E
authors.lastname: Kilic-Toprak
authors.forename: Goksel
authors.initials: G
authors.lastname: Altinisik
authors.forename: Ozgen
authors.initials: O
authors.lastname: Kilic-Erkek
authors.forename: Betul
authors.initials: B
authors.lastname: Cengiz
authors.forename: Vural
authors.initials: V
authors.lastname: Kucukatay
authors.forename: Hande
authors.initials: H
authors.lastname: Senol
authors.forename: Ismail Hakki
authors.initials: IH
authors.lastname: Akbudak
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Ekbic
authors.forename: Melek
authors.initials: M
authors.lastname: Bor-Kucukatay
mesh_terms: D000368:Aged; D000975:Antioxidants / Q000032:analysis; D015415:Biomarkers / Q000097:blood; D001809:Blood Viscosity; D016022:Case-Control Studies; D018549:Cryptogenic Organizing Pneumonia / Q000097:blood / Q000175:diagnosis; D004903:Erythrocyte Aggregation; D004907:Erythrocyte Deformability; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D054988:Idiopathic Interstitial Pneumonias / Q000097:blood* / Q000175:diagnosis; D054990:Idiopathic Pulmonary Fibrosis / Q000097:blood / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress
chemical_list: D000975:Antioxidants; D015415:Biomarkers
keywords: Erythrocyte aggregation; Erythrocyte deformability; Keywords: Idiopathic interstitial pneumonia; Viscosity, Oxidative stress.