title: Hydrogels with Lotus Leaf Topography: Investigating Surface Properties and Cell Adhesion.
abstract: The interactions of cells with the surface of materials is known to be influenced by a range of factors that include chemistry and roughness; however, it is often difficult to probe these factors individually without also changing the others. Here we investigate the role of roughness on cell adhesion while maintaining the same underlying chemistry. This was achieved by using a polymerization in mold technique to prepare poly(hydroxymethyl methacrylate) hydrogels with either a flat topography or a topography that replicated the microscale features of lotus leaves. These materials were then assessed for cell adhesion, and atomic force microscopy and contact angle analysis were then used to probe the physical reasons for the differing behavior in relation to cell adhesion.
authors.affiliation: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland , St. Lucia, Queensland 4072, Australia.
authors.forename: Miriem
authors.initials: M
authors.lastname: Santander-Borrego
authors.affiliation: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland , St. Lucia, Queensland 4072, Australia.|Australian National Fabrication Facility-Queensland Node , St. Lucia, Queensland 4072, Australia.
authors.forename: Elena
authors.initials: E
authors.lastname: Taran
authors.affiliation: Queensland Eye Institute , 140 Melbourne Street, South Brisbane, Queensland 4101, Australia.
authors.forename: Audra M A
authors.initials: AM
authors.lastname: Shadforth
authors.affiliation: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland , St. Lucia, Queensland 4072, Australia.|Centre for Advanced Imaging, The University of Queensland , St. Lucia, Queensland 4072, Australia.|Queensland Eye Institute , 140 Melbourne Street, South Brisbane, Queensland 4101, Australia.
authors.forename: Andrew K
authors.initials: AK
authors.lastname: Whittaker
authors.affiliation: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland , St. Lucia, Queensland 4072, Australia.|Faculty of Medicine and Biomedical Sciences, The University of Queensland , Herston Road, Herston, Queensland 4029, Australia.|Queensland Eye Institute , 140 Melbourne Street, South Brisbane, Queensland 4101, Australia.|Science & Engineering Faculty, Queensland University of Technology , 2 George Street Brisbane, Queensland 4001, Australia.|Faculty of Science, The University of Western Australia , Crawley, Western Australia 6009, Australia.
authors.forename: Traian V
authors.initials: TV
authors.lastname: Chirila
authors.affiliation: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland , St. Lucia, Queensland 4072, Australia.|Centre for Advanced Imaging, The University of Queensland , St. Lucia, Queensland 4072, Australia.|Queensland Eye Institute , 140 Melbourne Street, South Brisbane, Queensland 4101, Australia.
authors.forename: Idriss
authors.identifier: 0000-0003-2389-6156
authors.initials: I
authors.lastname: Blakey
mesh_terms: D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D006801:Humans; D020100:Hydrogels / Q000737:chemistry* / Q000494:pharmacology; D000070116:Lotus / Q000033:anatomy & histology*; D018625:Microscopy, Atomic Force; D018515:Plant Leaves / Q000033:anatomy & histology*; D011102:Polyhydroxyethyl Methacrylate / Q000737:chemistry / Q000494:pharmacology
chemical_list: D020100:Hydrogels; D011102:Polyhydroxyethyl Methacrylate