title: CORRELATION OF NON-ALCOHOLIC FATTY LIVER DISEASE AND FEATURES OF METABOLIC SYNDROME IN MORBIDLY OBESE PATIENTS IN THE PREOPERATIVE ASSESSMENT FOR BARIATRIC SURGERY.
abstract: Obesity is an epidemic and chronic disease that can bring other comorbidities to the patient. Non-alcoholic fatty liver disease is present in up to 90% of these patients and can progress to hepatitis and hepatocarcinoma. The relationship of this liver disease and obesity is already well known; however, it is possible that some parameters of the comorbidities are more related than others in the pathophysiology of the disease.
  
  
  
  Was analyzed the relationship between non-alcoholic fatty liver disease (NAFLD) and the comorbidities of metabolic syndrome in morbidly obese patients.
  
  
  
  Was involved ultrasonography and laboratory assessment of obese patients before bariatric surgery. NAFLD was assessed using the same sonography parameters for all patients. Based on the results, the patients were divided into groups with and without NAFLD. Comparisons between them involved clinical and laboratory variables such as fasting blood glucose, insulin, HOMA-IR (homeostasis model assessment - insulin resistance), glycated hemoglobin, total cholesterol and fractions, triglycerides, alanine aminotransferase, aspartate aminotransferase, gamma glutamyl transferase, C-reactive protein, albumin and ferritin. Patients who reported alcohol abuse (defined as the consumption of >14 drinks per week) or who had hepatitis were excluded.
  
  
  
  Eighty-two patients (74 women and 8 men) were studied, of whom 53 (64.6%) had NAFLD and 29 (35.4%) did not. The levels of glycated hemoglobin (p=0.05) and LDL cholesterol (p=0.01) were significantly altered in patients with NAFLD. However, weight, body mass index and excess weight did not differ significantly between the groups (p=0.835, p=0.488 and p=0.727, respectively).
  
  
  
  Altered LDL cholesterol and glycated hemoglobin levels were related to the presence of NAFLD.
authors.affiliation: Andarai Federal Hospital, Department of Bariatric and Metabolic Surgery, Rio de Janeiro.|FIOCRUZ, Clinical Research, Rio de Janeiro.
authors.forename: Fernando de
authors.initials: F
authors.lastname: Barros
authors.affiliation: Postgraduate Program in Medical Sciences, Fluminense Federal University, Niteroi.
authors.forename: Sergio
authors.initials: S
authors.lastname: Setúbal
authors.affiliation: Department of General and Specialized Surgery, Fluminense Federal University, Niteroi, RJ, Brazil.
authors.forename: José Manoel
authors.initials: JM
authors.lastname: Martinho
authors.affiliation: Andarai Federal Hospital, Department of Bariatric and Metabolic Surgery, Rio de Janeiro.
authors.forename: Loraine
authors.initials: L
authors.lastname: Ferraz
authors.affiliation: Andarai Federal Hospital, Department of Bariatric and Metabolic Surgery, Rio de Janeiro.
authors.forename: Andressa
authors.initials: A
authors.lastname: Gaudêncio
mesh_terms: D000328:Adult; D050110:Bariatric Surgery; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications*; D065626:Non-alcoholic Fatty Liver Disease / Q000150:complications*; D009767:Obesity, Morbid / Q000150:complications* / Q000601:surgery*; D011300:Preoperative Care