title: Amino acid chelated iron versus an iron salt in the treatment of iron deficiency anemia with pregnancy: A randomized controlled study.
abstract: OBJECTIVE
  The aim of this study was to compare the efficacy and tolerability of iron amino acid chelate (IAAC) and ferrous fumarate (FF) in treatment of iron deficiency anemia (IDA) with pregnancy.
  
  
  METHODS
  A total of 150 pregnant women having iron deficiency anemia (IDA) were randomized to receive either IAAC or FF for 12 weeks. Hemoglobin, red cell indices, serum iron, and serum ferritin were measured at baseline and then 4, 8, and 12 weeks after treatment. Adverse effects were questioned in both groups.
  
  
  RESULTS
  The mean values of hemoglobin, red cell indices, serum iron, and serum ferritin were not significantly different between both groups after 12 weeks of treatment. However, the rise in hemoglobin level after 4, 8, and 12 weeks of treatment was significantly faster in the IAAC group (p=<0.001). Constipation and abdominal colicky pain were significantly more common in the FF group (p=0.022 and 0.031 respectively).
  
  
  CONCLUSIONS
  IAAC and FF are comparable in curing IDA with pregnancy; however, IAAC has the advantage of providing a faster rate of improvement of hemoglobin level and is better tolerated by the patients.
authors.affiliation: Obstetrics and Gynecology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
authors.forename: Ghada Abdel Fattah
authors.initials: GAF
authors.lastname: Abdel Moety
authors.affiliation: Obstetrics and Gynecology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
authors.forename: Ahmed Mahmoud
authors.initials: AM
authors.lastname: Ali
authors.affiliation: Obstetrics and Gynecology Department, Faculty of Medicine, Cairo University, Cairo, Egypt. Electronic address: rehamfouad@rocketmail.com.
authors.forename: Reham
authors.initials: R
authors.lastname: Fouad
authors.affiliation: Obstetrics and Gynecology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
authors.forename: Wafaa
authors.initials: W
authors.lastname: Ramadan
authors.affiliation: Obstetrics and Gynecology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
authors.forename: Doaa Shafie
authors.initials: DS
authors.lastname: Belal
authors.affiliation: Obstetrics and Gynecology Department, Faculty of Medicine, Cairo University, Cairo, Egypt; Obstetrics and Gynecology Department, University of Wuerzburg, Wuerzburg, Germany.
authors.forename: Hisham Mamdouh
authors.initials: HM
authors.lastname: Haggag
mesh_terms: D015746:Abdominal Pain / Q000139:chemically induced; D000328:Adult; D000596:Amino Acids / Q000627:therapeutic use*; D018798:Anemia, Iron-Deficiency / Q000188:drug therapy*; D003248:Constipation / Q000139:chemically induced; D005260:Female; D005296:Ferrous Compounds / Q000627:therapeutic use*; D006801:Humans; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000188:drug therapy*; D014131:Trace Elements / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D000596:Amino Acids; D005296:Ferrous Compounds; D014131:Trace Elements; C031621:ferrous fumarate
keywords: Ferrous fumarate; Iron amino acid chelate; Iron deficiency anemia with pregnancy; Safety; Treatment