title: Single Cell Mathematical Model Successfully Replicates Key Features of GBM: Go-Or-Grow Is Not Necessary.
abstract: Glioblastoma (GBM) is a malignant brain tumor that continues to be associated with neurological morbidity and poor survival times. Brain invasion is a fundamental property of malignant glioma cells. The Go-or-Grow (GoG) phenotype proposes that cancer cell motility and proliferation are mutually exclusive. Here, we construct and apply a single glioma cell mathematical model that includes motility and angiogenesis and lacks the GoG phenotype. Simulations replicate key features of GBM including its multilayer structure (i.e.edema, enhancement, and necrosis), its progression patterns associated with bevacizumab treatment, and replicate the survival times of GBM treated or untreated with bevacizumab. These results suggest that the GoG phenotype is not a necessary property for the formation of the multilayer structure, recurrence patterns, and the poor survival times of patients diagnosed with GBM.
authors.affiliation: The University of Alabama, Birmingham, Department of Mathematics, Birmingham, Alabama, United States of America.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Scribner
authors.affiliation: The University of Alabama, Birmingham, Department of Mathematics, Birmingham, Alabama, United States of America.|The University of Alabama, Birmingham, Department of Neurology, Birmingham, Alabama, United States of America.
authors.forename: Hassan M
authors.identifier: http://orcid.org/0000-0002-2690-7685
authors.initials: HM
authors.lastname: Fathallah-Shaykh
mesh_terms: D000465:Algorithms; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D000068258:Bevacizumab / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000473:pathology / Q000628:therapy*; D045744:Cell Line, Tumor; D018450:Disease Progression; D005909:Glioblastoma / Q000473:pathology / Q000628:therapy*; D006801:Humans; D000860:Hypoxia; D008954:Models, Biological; D008962:Models, Theoretical; D009336:Necrosis; D009364:Neoplasm Recurrence, Local; D009389:Neovascularization, Pathologic; D010641:Phenotype
chemical_list: D020533:Angiogenesis Inhibitors; D000068258:Bevacizumab