title: Vertebral Tortuosity Index in Patients with Non-Connective Tissue Disorder-Related Aneurysm Disease.
abstract: OBJECTIVE
  The vertebral tortuosity index (VTI) predicts increased risk of acute aortic events in patients with known genetic aortopathies. This study describes the VTI in a cohort of patients with non-connective tissue disorder-related large aneurysms.
  
  
  METHODS
  Hospital imaging records from July 2012 to March 2016 were interrogated to identify patients with aneurysmal disease who had undergone computed tomographic angiography that included imaging of vertebral arteries. A control group of consecutive patients undergoing carotid and vertebral imaging was also assessed. VTI was calculated using the formula: [(centre-line distance) / (straight-line distance)-1] ×100 for all patients, and statistical analysis undertaken to determine whether measured VTI was statistically different in patients of younger age, with larger aneurysms, or an acute presentation. Comparison was made with patients who had no aneurysm disease.
  
  
  RESULTS
  Sixty-five patients were identified with adequate imaging to assess the entire aorta, including vertebral arteries. The majority of patients were male (71%, 46/65) and mean age at the time of the CT scan was 71 years (SD 11.1 years). There were 11 patients under the age of 60 years in this cohort. The mean VTI was 33.17 (SD 20.43). There was no statistically significant difference between different territories of presentation (proximal vs. distal aneurysm, p=.94), age of patient (>60 years vs. <60 years, p=.2), or size of aneurysm (>6 cm vs. <6 cm, p=.09). Acuity of presentation was not predicted by a higher VTI (p=.69). The VTI in patients with aneurysms was higher than in patients without aneurysm disease (VTI = 16.1, p<.005) CONCLUSIONS: An elevated VTI is consistently present in patients with degenerative aneurysms and has potential as a universally available predictive measurement. However, the increased VTI in the older cohort without connective tissue disease may not carry the same predictive value for acute presentations as has been demonstrated in younger patients with a known genetic basis for their aortopathy.
authors.affiliation: Royal Free London, London, UK.
authors.forename: F
authors.initials: F
authors.lastname: Virgilio
authors.affiliation: Royal Free London, London, UK.
authors.forename: B
authors.initials: B
authors.lastname: Maurel
authors.affiliation: Royal Free London, London, UK.
authors.forename: M
authors.initials: M
authors.lastname: Davis
authors.affiliation: Royal Free London, London, UK.
authors.forename: G
authors.initials: G
authors.lastname: Hamilton
authors.affiliation: Royal Free London, London, UK. Electronic address: tara.mastracci@nhs.net.
authors.forename: T M
authors.initials: TM
authors.lastname: Mastracci
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000784:Aortic Dissection / Q000000981:diagnostic imaging* / Q000209:etiology; D017544:Aortic Aneurysm, Abdominal / Q000000981:diagnostic imaging* / Q000209:etiology; D017545:Aortic Aneurysm, Thoracic / Q000000981:diagnostic imaging* / Q000209:etiology; D001027:Aortography / Q000379:methods*; D016022:Case-Control Studies; D000072226:Computed Tomography Angiography; D005260:Female; D006801:Humans; D017543:Iliac Aneurysm / Q000000981:diagnostic imaging* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D014711:Vertebral Artery / Q000000981:diagnostic imaging*
keywords: Aneurysm; Connective tissue disease; Thoracoabdominal aneurysm; Vertebral tortuosity