title: Synthesis and antimicrobial studies of novel derivatives of 4-(4-formyl-3-phenyl-1H-pyrazol-1-yl)benzoic acid as potent anti-Acinetobacter baumannii agents.
abstract: Microbial resistance to antibiotics is a global concern. The World Health Organization (WHO) has identified antimicrobial resistance as one the three greatest threats for human beings in the 21st century. Without urgent and coordinated action, the world is moving toward a post-antibiotic era, in which normal infections or minor injuries may become fatal. In an effort to find new agents, we report the synthesis and antimicrobial activities of 40 novel 1,3-diphenyl pyrazole derivatives. These compounds have shown zones of growth inhibition up to 85mm against Acinetobacter baumannii. We tested the active compounds against this Gram-negative bacterium in minimum inhibitory concentration (MIC) tests and found activity with concentration as low as 4μg/mL.
authors.affiliation: Department of Chemistry and Physics, College of Science and Mathematics, Arkansas State University, Jonesboro, AR 72467, United States.
authors.forename: Devin
authors.initials: D
authors.lastname: Allison
authors.affiliation: Department of Chemistry and Physics, College of Science and Mathematics, Arkansas State University, Jonesboro, AR 72467, United States.
authors.forename: Evan
authors.initials: E
authors.lastname: Delancey
authors.affiliation: Department of Chemistry and Physics, College of Science and Mathematics, Arkansas State University, Jonesboro, AR 72467, United States.
authors.forename: Hunter
authors.initials: H
authors.lastname: Ramey
authors.affiliation: Department of Chemistry and Physics, College of Science and Mathematics, Arkansas State University, Jonesboro, AR 72467, United States.
authors.forename: Conrad
authors.initials: C
authors.lastname: Williams
authors.affiliation: Department of Chemistry and Physics, College of Science and Mathematics, Arkansas State University, Jonesboro, AR 72467, United States.
authors.forename: Zakeyah Ali
authors.initials: ZA
authors.lastname: Alsharif
authors.affiliation: Department of Chemistry and Physics, College of Science and Mathematics, Arkansas State University, Jonesboro, AR 72467, United States.
authors.forename: Hessa
authors.initials: H
authors.lastname: Al-Khattabi
authors.affiliation: Department of Chemistry and Physics, College of Science and Mathematics, Arkansas State University, Jonesboro, AR 72467, United States.
authors.forename: Allyn
authors.initials: A
authors.lastname: Ontko
authors.affiliation: Department of Biological Sciences, College of Science and Mathematics, Arkansas State University, Jonesboro, AR 72467, United States.
authors.forename: David
authors.initials: D
authors.lastname: Gilmore
authors.affiliation: Department of Chemistry and Physics, College of Science and Mathematics, Arkansas State University, Jonesboro, AR 72467, United States. Electronic address: malam@astate.edu.
authors.forename: Mohammad A
authors.initials: MA
authors.lastname: Alam
mesh_terms: D040981:Acinetobacter baumannii / Q000187:drug effects / Q000201:enzymology; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D019817:Benzoic Acid / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001665:Binding Sites; D020134:Catalytic Domain; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D062105:Molecular Docking Simulation; D011720:Pyrazoles / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D000890:Anti-Infective Agents; D011720:Pyrazoles; C031280:pyrazole; D019817:Benzoic Acid
keywords: Acinetobacter baumannii; Antibacterial; Antimicrobials; Hydrazone; Methicillin-resistant Staphylococcus aureus (MRSA); Pyrazole; Resistant