title: Characteristics of Adenovirus Pneumonia in Korean Military Personnel, 2012-2016.
abstract: Adenovirus (AdV) can cause severe pneumonia in non-immunocompromised host, but limited data exist on the distinctive characteristics of AdV pneumonia in non-immunocompromised patients. We evaluated distinctive clinico-laboratory and radiological characteristics and outcomes of AdV pneumonia (n = 179), compared with non-AdV pneumonia (n = 188) in Korean military personnel between 2012 and 2016. AdV pneumonia patients had a higher rate of consolidation with ground-glass opacity (101/152) in lobar distribution (89/152) on computed tomography (CT) (P < 0.001). Laboratory findings showed a higher incidence of unusual blood profiles such as leukopenia (55/179, P < 0.001) or thrombocytopenia (100/179, P < 0.001). The patients had more systemic symptoms such as myalgia (82/179, P = 0.001) or diarrhea (23/179, P < 0.001), compared with non-AdV pneumonia patients. Bacterial co-infection was identified in 28.5% of AdV pneumonia. Most of the AdV isolates typed (69/72, 95.8%) were AdV-55. Patients with a pneumonia severity index ≥ class III were more commonly observed in AdV pneumonia patients compared with non-AdV pneumonia patients (11.2% vs. 2.1%, P < 0.001), and time to clinical stabilization from admission was longer in the AdV pneumonia patients compared with the non-AdV pneumonia patients (3.8 vs. 2.6 days, P < 0.001). Mechanical ventilation (n = 6) was only required in AdV pneumonia patients, one of whom died due to AdV-55. Our data showed that AdV pneumonia in non-immunocompromised patients had distinct characteristics and most of the isolates typed in our study were AdV-55. It is suggested that AdV-55 is an important pathogen of pneumonia in Korean military personnel.
authors.affiliation: Department of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Hee
authors.initials: H
authors.lastname: Yoon
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.|Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Armed Forces Capital Hospital, Seongnam, Korea. byungwoo.jhun@gmail.com.
authors.forename: Byung Woo
authors.identifier: http://orcid.org/0000-0002-6348-8731
authors.initials: BW
authors.lastname: Jhun
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Hojoong
authors.identifier: http://orcid.org/0000-0001-9207-0433
authors.initials: H
authors.lastname: Kim
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Armed Forces Capital Hospital, Seongnam, Korea.
authors.forename: Hongseok
authors.initials: H
authors.lastname: Yoo
authors.affiliation: Department of Public Health and Operation, The Armed Forces Medical Command, Seongnam, Korea.
authors.forename: Sung Bum
authors.initials: SB
authors.lastname: Park
mesh_terms: D000256:Adenoviridae / Q000235:genetics / Q000302:isolation & purification*; D000328:Adult; D044466:Asian People; D060085:Coinfection / Q000175:diagnosis; D004279:DNA, Viral / Q000235:genetics / Q000378:metabolism; D003967:Diarrhea / Q000209:etiology; D006801:Humans; D007970:Leukopenia / Q000209:etiology; D008297:Male; D008889:Military Personnel; D063806:Myalgia / Q000209:etiology; D011014:Pneumonia / Q000175:diagnosis / Q000453:epidemiology; D011024:Pneumonia, Viral / Q000175:diagnosis* / Q000453:epidemiology / Q000821:virology; D016133:Polymerase Chain Reaction; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013909:Thorax / Q000000981:diagnostic imaging; D013921:Thrombocytopenia / Q000209:etiology; D014057:Tomography, X-Ray Computed; D055815:Young Adult
chemical_list: D004279:DNA, Viral
keywords: Adenovirus; Consolidation; Pneumonia; Thrombocytopenia