title: Enthalpic Effects of Chain Length and Unsaturation on Water Permeability across Droplet Bilayers of Homologous Monoglycerides.
abstract: A deeper understanding of unassisted passive transport processes can better delineate basic lipid dynamics in biological membranes. A droplet interface bilayer (DIB) is made by contacting two aqueous droplets covered with a lipid monolayer, and has increasingly been employed as a model artificial biological membrane. In this study, we have investigated the effect of acyl chain structure of amphiphilic monoglycerides on the osmotic permeability of water across DIB membranes composed of these monoglycerides, where the acyl chain length (C14-C24), number of double bonds (1-4), and the position of double bond are varied systematically along the acyl chains. Both permeability values and activation energies have been extracted for water transport across a lipid bilayer formed of a homologous series of lipids, allowing us to make ready comparisons between the different lipids and potentially better elucidate the contributions that molecular motifs make to the permeation process.
authors.affiliation: Department of Chemistry, Iona College , 715 North Avenue, New Rochelle, New York 10801, United States.
authors.forename: Maria
authors.initials: M
authors.lastname: Lopez
authors.affiliation: Department of Chemistry, Iona College , 715 North Avenue, New Rochelle, New York 10801, United States.
authors.forename: Sue Ellen
authors.initials: SE
authors.lastname: Evangelista
authors.affiliation: Department of Chemistry, Iona College , 715 North Avenue, New Rochelle, New York 10801, United States.
authors.forename: Melissa
authors.initials: M
authors.lastname: Morales
authors.affiliation: Department of Chemistry, Iona College , 715 North Avenue, New Rochelle, New York 10801, United States.
authors.forename: Sunghee
authors.identifier: 0000-0003-2481-7982
authors.initials: S
authors.lastname: Lee
mesh_terms: D002462:Cell Membrane / Q000737:chemistry; D008051:Lipid Bilayers / Q000737:chemistry*; D050178:Monoglycerides / Q000737:chemistry*; D010539:Permeability; D013816:Thermodynamics; D014867:Water / Q000737:chemistry*
chemical_list: D008051:Lipid Bilayers; D050178:Monoglycerides; D014867:Water