title: Biocompatible CuS-based nanoplatforms for efficient photothermal therapy and chemotherapy in vivo.
abstract: Near-infrared (NIR) photothermal therapy (PTT) is a new approach to ablate cancer without affecting normal tissues. A pivotal concern of PPT is to develop photo-responsive agents with high biocompatibility as well as effective photothermal conversion efficiency. Copper sulfide (CuS) nanoparticles prepared are characterized by their low synthesis cost, wide NIR absorption range, good biocompatibility and favorable NIR photothermal conversion efficiency. CuS nanoparticles were then coated with mesoporous silicon dioxide (SiO2) by the Stober method, and further loaded with anticancer drug doxorubicin (DOX). The nanocomposites obtained were named CuS@MSN-DOX. The infrared thermal imaging of CuS@MSN-DOX demonstrated its favorable photothermal efficacy. The potential of CuS@MSN-DOX utilized as a multifunctional platform for combined PPT and chemotherapy was exploited both at the cell level and in a mice model. The result demonstrated that CuS@MSN-DOX was endowed with the synergistic effect of chemo-photothermal therapy, which confirmed that it is a promising candidate for combined therapy of cancer.
authors.affiliation: Department of Biomedical Engineering, School of Engineering, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjia Lane, Gulou District, Nanjing 210009, China. guyueqing@hotmail.com chenhaiyan@cpu.edu.cn.
authors.forename: Shuwen
authors.initials: S
authors.lastname: Peng
authors.affiliation: Department of Biomedical Engineering, School of Engineering, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjia Lane, Gulou District, Nanjing 210009, China. guyueqing@hotmail.com chenhaiyan@cpu.edu.cn.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: He
authors.affiliation: Department of Biomedical Engineering, School of Engineering, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjia Lane, Gulou District, Nanjing 210009, China. guyueqing@hotmail.com chenhaiyan@cpu.edu.cn.
authors.forename: Murat
authors.initials: M
authors.lastname: Er
authors.affiliation: Department of Biomedical Engineering, School of Engineering, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjia Lane, Gulou District, Nanjing 210009, China. guyueqing@hotmail.com chenhaiyan@cpu.edu.cn.
authors.forename: Yuanzhi
authors.initials: Y
authors.lastname: Sheng
authors.affiliation: Department of Biomedical Engineering, School of Engineering, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjia Lane, Gulou District, Nanjing 210009, China. guyueqing@hotmail.com chenhaiyan@cpu.edu.cn.
authors.forename: Yueqing
authors.initials: Y
authors.lastname: Gu
authors.affiliation: Department of Biomedical Engineering, School of Engineering, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjia Lane, Gulou District, Nanjing 210009, China. guyueqing@hotmail.com chenhaiyan@cpu.edu.cn.
authors.forename: Haiyan
authors.identifier: http://orcid.org/0000-0002-1652-2730
authors.initials: H
authors.lastname: Chen
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D003300:Copper / Q000627:therapeutic use*; D004317:Doxorubicin / Q000008:administration & dosage / Q000627:therapeutic use*; D065546:Drug Liberation; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods; D051379:Mice; D053758:Nanoparticles / Q000627:therapeutic use*; D009369:Neoplasms / Q000628:therapy*; D010789:Phototherapy / Q000379:methods; D012822:Silicon Dioxide / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D012822:Silicon Dioxide; D003300:Copper; D004317:Doxorubicin; C017846:cupric sulfide