title: Modeling white matter microstructure.
abstract: Quantitative magnetic resonance imaging can be combined with advanced biophysical models to measure microstructural features of white matter. Non-invasive microstructural imaging has the potential to revolutionize neuroscience, and acquiring these measures in clinically feasible times would greatly improve patient monitoring and clinical studies of drug efficacy. However, a good understanding of microstructural imaging techniques is essential to set realistic expectations and to prevent over-interpretation of results. This review explains the methodology behind microstructural modeling and imaging, and gives an overview of the breakthroughs and challenges associated with it.
authors.forename: T
authors.initials: T
authors.lastname: Duval
authors.forename: N
authors.initials: N
authors.lastname: Stikov
authors.forename: J
authors.initials: J
authors.lastname: Cohen-Adad
mesh_terms: D001921:Brain / Q000033:anatomy & histology / Q000000981:diagnostic imaging*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008959:Models, Neurological; D066127:White Matter / Q000033:anatomy & histology / Q000000981:diagnostic imaging*