title: Identification of pyripyropene A as a promising insecticidal compound in a microbial metabolite screening.
abstract: Approximately 300 microbial natural products in our library were screened for insecticidal activities against three species of agricultural pests, including aphids. Among the several compounds that showed insecticidal activities, pyripyropene A had high aphicidal activity in vivo. Furthermore, in advanced tests, pyripyropene A applications with foliar sprays and soil drenching controlled aphids on cabbage. On the basis of its unique and promising activities, we selected pyripyropene A as the active component of potential insecticides.
authors.affiliation: Agricultural & Veterinary Research Labs, Agricultural & Veterinary Division, Meiji Seika Pharma Co, Ltd, Yokohama, Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Horikoshi
authors.affiliation: Agricultural & Veterinary Research Labs, Agricultural & Veterinary Division, Meiji Seika Pharma Co, Ltd, Yokohama, Japan.
authors.forename: Kimihiko
authors.initials: K
authors.lastname: Goto
authors.affiliation: Agricultural & Veterinary Research Labs, Agricultural & Veterinary Division, Meiji Seika Pharma Co, Ltd, Yokohama, Japan.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Mitomi
authors.affiliation: Agricultural & Veterinary Research Labs, Agricultural & Veterinary Division, Meiji Seika Pharma Co, Ltd, Yokohama, Japan.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Oyama
authors.affiliation: Kitasato Institute for Life Sciences, Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan.
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Sunazuka
authors.affiliation: Kitasato Institute for Life Sciences, Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ōmura
mesh_terms: D000818:Animals; D001042:Aphids; D001937:Brassica; D007306:Insecticides / Q000633:toxicity*; D015394:Molecular Structure; D009036:Moths; D011725:Pyridines / Q000633:toxicity*; D012717:Sesquiterpenes / Q000633:toxicity*; D040102:Tetranychidae
chemical_list: D007306:Insecticides; D011725:Pyridines; D012717:Sesquiterpenes; C082792:pyripyropene A