title: Ipsilateral Dual-Site, Same-Sitting Percutaneous Lung Biopsy: A Feasibility Study.
abstract: OBJECTIVE
  Patients with thoracic malignancies often have more than one site of pulmonary, nodal or pleural disease within one hemithorax. In addition, large heterogeneous lesions may comprise distinct, mixed pathological entities. Histological analysis of these lesions can alter tumour staging and treatment options. We investigated the feasibility, safety and benefit of performing image-guided percutaneous lung biopsy (PLB) of two lesions in the same hemithorax at a single sitting.
  
  
  METHODS
  Ten consecutive outpatients with two or more potential disease foci within the same hemithorax were analysed over a 15-month period. The mean age of the patients was 66 years (range 46-81 years). Patients underwent CT-guided coaxial 20G   core biopsy of both lesions, with separate coaxial punctures for each lesion. Patients were managed as per established local institution ambulatory lung biopsy protocol using small-calibre Heimlich-valve chest drain (HVCD) to treat significant post-PLB pneumothorax in an outpatient setting. Data regarding lesion characteristics, diagnoses and complications were recorded.
  
  
  RESULTS
  All 10 patients (n = 20 biopsies, 100% technical success) received informative histological diagnosis on both lesions. This altered management in all cases. Although a high rate of pneumothorax occurred (60%; 6/10), only two of these patients required treatment with HVCD. No other significant complications occurred in those patients with small asymptomatic pneumothoraces or those that required HVCD placement.
  
  
  CONCLUSIONS
  Dual-site lung biopsy, performed as a single procedure, is potentially a safe and effective technique for diagnosing patients with multiple thoracic lesions, and can provide useful staging information to guide patient management.
authors.affiliation: Department of Radiology, Barnet Hospital, Royal Free London NHS Foundation Trust, Wellhouse Lane, Barnet, London, EN5 3DJ, UK.
authors.forename: Joseph
authors.initials: J
authors.lastname: Barnett
authors.affiliation: Department of Radiology, Barnet Hospital, Royal Free London NHS Foundation Trust, Wellhouse Lane, Barnet, London, EN5 3DJ, UK.
authors.forename: Aniket N
authors.initials: AN
authors.lastname: Tavare
authors.affiliation: Department of Respiratory Medicine, Barnet Hospital, Royal Free London NHS Foundation Trust, London, UK.
authors.forename: Sajid
authors.initials: S
authors.lastname: Khan
authors.affiliation: Department of Radiology, Barnet Hospital, Royal Free London NHS Foundation Trust, Wellhouse Lane, Barnet, London, EN5 3DJ, UK.
authors.forename: Ashish
authors.initials: A
authors.lastname: Saini
authors.affiliation: Department of Respiratory Medicine, Barnet Hospital, Royal Free London NHS Foundation Trust, London, UK.
authors.forename: Dean D
authors.initials: DD
authors.lastname: Creer
authors.affiliation: Department of Radiology, Barnet Hospital, Royal Free London NHS Foundation Trust, Wellhouse Lane, Barnet, London, EN5 3DJ, UK. samhare@nhs.net.
authors.forename: Samanjit S
authors.initials: SS
authors.lastname: Hare
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle / Q000379:methods; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D061705:Image-Guided Biopsy / Q000379:methods; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011030:Pneumothorax / Q000000981:diagnostic imaging / Q000473:pathology*; D015641:Radiography, Interventional; D014057:Tomography, X-Ray Computed / Q000379:methods
keywords: Interventional oncology; Lung biopsy; Lung cancer; Pneumothorax