title: Dietary Patterns and Pancreatic Cancer Risk: A Meta-Analysis.
abstract: A number of studies have examined the associations between dietary patterns and pancreatic cancer risk, but the findings have been inconclusive. Herein, we conducted this meta-analysis to assess the associations between dietary patterns and the risk of pancreatic cancer. MEDLINE (provided by the National Library of Medicine) and EBSCO (Elton B. Stephens Company) databases were searched for relevant articles published up to May 2016 that identified common dietary patterns. Thirty-two studies met the inclusion criteria and were finally included in this meta-analysis. A reduced risk of pancreatic cancer was shown for the highest compared with the lowest categories of healthy patterns (odds ratio, OR = 0.86; 95% confidence interval, CI: 0.77-0.95;p= 0.004) and light-moderate drinking patterns (OR = 0.90; 95% CI: 0.83-0.98;p= 0.02). There was evidence of an increased risk for pancreatic cancer in the highest compared with the lowest categories of western-type pattern (OR = 1.24; 95% CI: 1.06-1.45;p= 0.008) and heavy drinking pattern (OR = 1.29; 95% CI: 1.10-1.48;p= 0.002). The results of this meta-analysis demonstrate that healthy and light-moderate drinking patterns may decrease the risk of pancreatic cancer, whereas western-type and heavy drinking patterns may increase the risk of pancreatic cancer. Additional prospective studies are needed to confirm these findings.
authors.affiliation: Department of Geriatrics, Zhejiang Hospital, Xihu District, Hangzhou 310013, China. lupy007@sina.com.
authors.forename: Pei-Ying
authors.initials: PY
authors.lastname: Lu
authors.affiliation: Department of Nutrition, Zhejiang Hospital, Xihu District, Hangzhou 310013, China. shulong19880920@126.com.
authors.forename: Long
authors.initials: L
authors.lastname: Shu
authors.affiliation: Department of Geriatrics, Zhejiang Hospital, Xihu District, Hangzhou 310013, China. shenshan305@163.com.
authors.forename: Shan-Shan
authors.initials: SS
authors.lastname: Shen
authors.affiliation: Department of Geriatrics, Zhejiang Hospital, Xihu District, Hangzhou 310013, China. lily197459@163.com.
authors.forename: Xu-Jiao
authors.initials: XJ
authors.lastname: Chen
authors.affiliation: Department of Nutrition, Zhejiang Hospital, Xihu District, Hangzhou 310013, China. zxy19740804@sina.com.
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Zhang
mesh_terms: D000428:Alcohol Drinking / Q000009:adverse effects; D000437:Alcoholism / Q000503:physiopathology; D016022:Case-Control Studies; D015331:Cohort Studies; D004032:Diet / Q000009:adverse effects*; D000072001:Diet, Healthy; D066273:Diet, Western / Q000009:adverse effects; D019317:Evidence-Based Medicine; D006801:Humans; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control; D010349:Patient Compliance; D012307:Risk Factors
keywords: alcohol consumption; dietary patterns; meta-analysis; pancreatic cancer