title: Maternal serum calponin 1 level as a biomarker for the short-term prediction of preterm birth in women with threatened preterm labor.
abstract: OBJECTIVE
  To assess the utility of maternal serum calponin 1 level in the prediction of delivery within 7 days among pregnancies complicated with threatened preterm labor.
  
  
  METHODS
  Eligible women who presented at 24-34 weeks of gestation with threatened preterm labor underwent sampling for serum calponin 1 level and cervical length measurement. They were followed up until delivery prospectively and the perinatal outcomes of the patients were recorded.
  
  
  RESULTS
  Of 73 women included in the study, 36 women delivered within 7 days and 37 women delivered beyond 7 days after admission. The maternal serum calponin 1 level was significantly high in women who delivered within 7 days (p: 0.031). The threshold value of 2 ng/mL for maternal serum calponin 1 predicted delivery within 7 days with 61.1% sensitivity and 62.2 specificity (area under curve, 0.658, confidence interval 0.53-0.79). The general accuracy values for maternal cervical length measurement (≤25 mm), serum calponin 1 level (>2 ng/mL) and the combination of two tests to predict delivery within 7 days was found to be 64.4%, 61.6% and 72.1%, respectively.
  
  
  CONCLUSIONS
  The maternal serum calponin 1 level may be a useful biomarker in short-term prediction of preterm birth among pregnancies complicated with threatened preterm labor, in addition to cervical length measurement.
authors.affiliation: a Department of Obstetrics and Gynecology, Faculty of Medicine , Yuzuncu Yil University , Van , Turkey.
authors.forename: Orkun
authors.initials: O
authors.lastname: Cetin
authors.affiliation: a Department of Obstetrics and Gynecology, Faculty of Medicine , Yuzuncu Yil University , Van , Turkey.
authors.forename: Erbil
authors.initials: E
authors.lastname: Karaman
authors.affiliation: a Department of Obstetrics and Gynecology, Faculty of Medicine , Yuzuncu Yil University , Van , Turkey.
authors.forename: Baris
authors.initials: B
authors.lastname: Boza
authors.affiliation: a Department of Obstetrics and Gynecology, Faculty of Medicine , Yuzuncu Yil University , Van , Turkey.
authors.forename: Numan
authors.initials: N
authors.lastname: Cim
authors.affiliation: a Department of Obstetrics and Gynecology, Faculty of Medicine , Yuzuncu Yil University , Van , Turkey.
authors.forename: Hanım Guler
authors.initials: HG
authors.lastname: Sahin
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood*; D002135:Calcium-Binding Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D008840:Microfilament Proteins / Q000097:blood*; D011247:Pregnancy; D047928:Premature Birth / Q000097:blood* / Q000453:epidemiology*; D011446:Prospective Studies; D012372:ROC Curve; D055815:Young Adult; D000096985:Calponins
chemical_list: D015415:Biomarkers; D002135:Calcium-Binding Proteins; D008840:Microfilament Proteins; D000096985:Calponins
keywords: Preterm birth; calponin 1; prediction; threatened preterm labor