title: Breast Cancer Profile among Patients with a History of Chemoprevention.
abstract: Purpose. This study identifies women with breast cancer who utilized chemoprevention agents prior to diagnosis and describes their patterns of disease.Methods. Our database was queried retrospectively for patients with breast cancer who reported prior use of chemoprevention. Patients were divided into primary (no history of breast cancer) and secondary (previous history of breast cancer) groups and compared to patients who never took chemoprevention.Results. 135 (6%) of 2430 women used chemoprevention. In the primary chemoprevention group (n= 18, 1%), 39% had completed >5 years of treatment, and fully 50% were on treatment at time of diagnosis. These patients were overwhelmingly diagnosed with ER/PR positive cancers (88%/65%) and were diagnosed with equal percentages (44%) of IDC and DCIS. 117 (87%) used secondary chemoprevention. Patients in this group were diagnosed with earlier stage disease and had lower rates of ER/PR-positivity (73%/65%) than the nonchemoprevention group (84%/72%). In the secondary group, 24% were on chemoprevention at time of diagnosis; 73% had completed >5 years of treatment.Conclusions. The majority of patients who used primary chemoprevention had not completed treatment prior to diagnosis, suggesting that the timing of initiation and compliance to prevention strategies are important in defining the pattern of disease in these patients.
authors.affiliation: Department of Surgery, New York University Langone Medical Center, New York, NY, USA.
authors.forename: Freya R
authors.identifier: 0000-0002-6393-7453
authors.initials: FR
authors.lastname: Schnabel
authors.affiliation: School of Medicine, New York University Langone Medical Center, New York, NY, USA.
authors.forename: Sarah
authors.initials: S
authors.lastname: Pivo
authors.affiliation: Department of Surgery, New York University Langone Medical Center, New York, NY, USA.
authors.forename: Jennifer
authors.identifier: 0000-0003-3752-6826
authors.initials: J
authors.lastname: Chun
authors.affiliation: Department of Surgery, New York University Langone Medical Center, New York, NY, USA.
authors.forename: Shira
authors.identifier: 0000-0002-7313-8540
authors.initials: S
authors.lastname: Schwartz
authors.affiliation: Department of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Refinetti
authors.affiliation: Department of Surgery, New York University Langone Medical Center, New York, NY, USA.
authors.forename: Deborah
authors.identifier: 0000-0002-9929-3389
authors.initials: D
authors.lastname: Axelrod
authors.affiliation: Department of Surgery, New York University Langone Medical Center, New York, NY, USA.
authors.forename: Amber
authors.initials: A
authors.lastname: Guth