title: Canine Idiopathic Chronic Hepatitis.
abstract: The World Small Animal Veterinary Association's Liver Standardization Group produced standardized criteria for the histologic diagnosis of canine chronic hepatitis (CH). They define CH by the presence of hepatocellular apoptosis or necrosis, a variable mononuclear or mixed inflammatory cell infiltrate, regeneration, and fibrosis. There are variations in histologic appearance between breeds. Hepatic copper accumulation is an important cause of canine CH. However, where copper accumulation has been ruled out, dogs are said to have idiopathic CH. This article reviews theories regarding the etiopathogenesis of canine CH other than copper accumulation, and its clinical features, diagnostic findings, and management.
authors.affiliation: School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, School Road, Leicestershire LE12 5RD, UK. Electronic address: nick.bexfield@nottingham.ac.uk.
authors.forename: Nick
authors.initials: N
authors.lastname: Bexfield
mesh_terms: D000818:Animals; D000933:Antifibrinolytic Agents / Q000627:therapeutic use; D004035:Diet Therapy / Q000662:veterinary; D004283:Dog Diseases / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D004285:Dogs; D005260:Female; D006520:Hepatitis, Animal / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D006521:Hepatitis, Chronic / Q000209:etiology / Q000503:physiopathology / Q000628:therapy / Q000662:veterinary*; D008297:Male; D011379:Prognosis; D012307:Risk Factors; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use
chemical_list: D000933:Antifibrinolytic Agents; D014580:Ursodeoxycholic Acid
keywords: Canine; Diagnosis; Hepatitis; Idiopathic; Management; Prognosis