title: Assessing the association between 25-OH vitamin D levels and ROMA score in a population of obese women.
abstract: The Risk of Malignancy Algorithm (ROMA) combines the diagnostic power of the CA125 and HE4 markers with menopausal status to predict the risk for developing epithelial ovarian cancer (EOC). The aim of this study was to evaluate the association between 25-OH vitamin D levels and ROMA score in obese women. One hundred and eighteen patients with a Body Mass Index (BMI) > 30 kg/m2 (Group 1) and 80 women with a BMI less than 25 kg / m² (Group 2) were studied. The 25-OH vitamin D was quantified with LUMIPULSE® G 1200. As a threshold value, identified by ROC curve analysis, 20.2 ng/ mL (sensitivity 73.3%, specificity 84%) was chosen corresponding to the limit between sufficient and insufficient 25-OH vitamin D according to the World Health Organization (WHO). Low 25-OH vitamin D levels were observed in 64% of obese women and in 11% of normal-weight women (p less than 0.001). ROMA score above 13% was detected only in obese women (19%). An association between low levels of 25-OH vitamin D and ROMA score was observed. Indeed, 64% of obese women with ROMA score >13% had concomitant insufficient levels of 25-OH vitamin D, while only 36% of obese women with ROMA score >13% had sufficient 25-OH vitamin D levels (p less than 0.0001). This study suggests that the deficiency of 25- OH vitamin D in obese women has a possible correlation with high ROMA score.
authors.affiliation: Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Anastasi
authors.affiliation: Department of Experimental Medicine, Sapienza University of Rome  Policlinico Umberto I, Rome, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Capoccia
authors.affiliation: CNR-IBPM, National Research Council, Rome, Italy.
authors.forename: T
authors.initials: T
authors.lastname: Granato
authors.affiliation: Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Viggiani
authors.affiliation: Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Tartaglione
authors.affiliation: Department of Radiology, Sapienza University, Rome, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Manganaro
authors.affiliation: Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Angeloni
authors.affiliation: Department of Experimental Medicine, Sapienza University of Rome  Policlinico Umberto I, Rome, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Leonetti
mesh_terms: D000328:Adult; D000465:Algorithms; D014408:Biomarkers, Tumor / Q000097:blood*; D015519:Bone Density; D000077216:Carcinoma, Ovarian Epithelial; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000097:blood / Q000150:complications; D009765:Obesity / Q000097:blood* / Q000150:complications; D010051:Ovarian Neoplasms / Q000097:blood / Q000150:complications; D012372:ROC Curve; D012307:Risk Factors; D012680:Sensitivity and Specificity; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D014807:Vitamin D; C104450:25-hydroxyvitamin D