title: Oligomer formation of a tea polyphenol, EGCG, on its sensing molecule 67 kDa laminin receptor.
abstract: Green tea polyphenol (-)-epigallocatechin-3-O-gallate (EGCG) has been attributed to the activation of its cell surface sensing receptor 67 kDa laminin receptor (67LR). However, the action of EGCG to activate 67LR remains unknown. Here we show that EGCG undergoes oligomer formation on its surface receptor 67LR.
authors.affiliation: Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan. tatibana@agr.kyushu-u.ac.jp.
authors.forename: Yuhui
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan. tatibana@agr.kyushu-u.ac.jp.
authors.forename: Mami
authors.initials: M
authors.lastname: Sumida
authors.affiliation: Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan. tatibana@agr.kyushu-u.ac.jp.
authors.forename: Motofumi
authors.initials: M
authors.lastname: Kumazoe
authors.affiliation: Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan. tatibana@agr.kyushu-u.ac.jp.
authors.forename: Kaori
authors.initials: K
authors.lastname: Sugihara
authors.affiliation: Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan. tatibana@agr.kyushu-u.ac.jp.
authors.forename: Yumi
authors.initials: Y
authors.lastname: Suemasu
authors.affiliation: Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan. tatibana@agr.kyushu-u.ac.jp.
authors.forename: Shuhei
authors.initials: S
authors.lastname: Yamada
authors.affiliation: Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan. tatibana@agr.kyushu-u.ac.jp.
authors.forename: Shuya
authors.initials: S
authors.lastname: Yamashita
authors.affiliation: Department of Applied Chemistry, Graduate School of Science and Engineering, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro, Tokyo 152-8552, Japan.
authors.forename: Jyunichi
authors.initials: J
authors.lastname: Miyakawa
authors.affiliation: Yokohama College of Pharmacy 601, Matana-cho, Totsuka-ku, Yokohama, Kanagawa 245-0066, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Takahashi
authors.affiliation: Department of Applied Chemistry, Graduate School of Science and Engineering, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro, Tokyo 152-8552, Japan.
authors.forename: Hiroshi
authors.identifier: http://orcid.org/0000-0002-3661-9310
authors.initials: H
authors.lastname: Tanaka
authors.affiliation: Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan. tatibana@agr.kyushu-u.ac.jp.
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Fujimura
authors.affiliation: Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan. tatibana@agr.kyushu-u.ac.jp.
authors.forename: Hirofumi
authors.identifier: http://orcid.org/0000-0003-4820-2122
authors.initials: H
authors.lastname: Tachibana
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D002392:Catechin / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000494:pharmacology; D016923:Cell Death / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D056945:Hep G2 Cells; D006801:Humans; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology; D017474:Receptors, Laminin / Q000737:chemistry / Q000378:metabolism*; D020349:Surface Plasmon Resonance; D013662:Tea / Q000737:chemistry*; D013816:Thermodynamics
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D010455:Peptides; D017474:Receptors, Laminin; D013662:Tea; D002392:Catechin; C045651:epigallocatechin gallate