title: Adrenal hormones before and after venography during adrenal venous sampling: a self-controlled study.
abstract: OBJECTIVE
  A stress reaction involving increased adrenal hormone release occurs when starting adrenal venous sampling (AVS). The purpose of the present study was to investigate the effect of single shot venography on adrenal hormone production during AVS.
  
  
  METHODS
  This was a prospective self-controlled study. We enrolled 54 consecutive patients (21 men, 33 women; mean age 52 ± 11 years) with primary aldosteronism who underwent AVS from May 2014 to February 2015. Under non-stimulated conditions, blood samples were obtained from a common trunk of the left adrenal vein before and after single shot venography. The initial plasma aldosterone and cortisol concentration (PAC and PCC) were compared with those measured after venography for each patient.
  
  
  RESULTS
  PAC and PCC were slightly but significantly decreased between before and after venography (after log transformation 2.12 ± 0.73 vs 2.07 ± 0.72, P = 0.00066, 1.89 ± 0.52 vs 1.83 ± 0.53, P = 0.00031, respectively).
  
  
  CONCLUSIONS
  During non-stimulated left AVS, adrenal hormone secretion was slightly but significantly decreased after venography, similar to the normal time-related stress reaction. Venography did not increase the adrenal hormone secretion.
authors.affiliation: Department of Interventional Radiology, Yokohama Rosai Hospital, 3211, Kozukue-cho, Kouhoku-Ku, Yokohama, Kanagawa, 222-0036, Japan. r06118@hotmail.co.jp.
authors.forename: Yuya
authors.initials: Y
authors.lastname: Koike
authors.affiliation: Department of Interventional Radiology, Yokohama Rosai Hospital, 3211, Kozukue-cho, Kouhoku-Ku, Yokohama, Kanagawa, 222-0036, Japan.
authors.forename: Seishi
authors.initials: S
authors.lastname: Matsui
authors.affiliation: Endocrinology and Diabetes Center, Yokohama Rosai Hospital, Yokohama, Japan.
authors.forename: Masao
authors.initials: M
authors.lastname: Omura
authors.affiliation: Department of Radiology, Nerima Hikarigaoka Hospital, Tokyo, Japan.
authors.forename: Kohzoh
authors.initials: K
authors.lastname: Makita
authors.affiliation: Department of Radiology, Yokohama Rosai Hospital, Yokohama, Japan.
authors.forename: Alfonso W D
authors.initials: AW
authors.lastname: Obara
authors.affiliation: Department of Radiology, Yokohama Rosai Hospital, Yokohama, Japan.
authors.forename: Nobukazu
authors.initials: N
authors.lastname: Moriya
authors.affiliation: Endocrinology and Diabetes Center, Yokohama Rosai Hospital, Yokohama, Japan.
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Nishikawa
mesh_terms: D000311:Adrenal Glands / Q000098:blood supply*; D000450:Aldosterone / Q000097:blood*; D001800:Blood Specimen Collection / Q000379:methods*; D002406:Catheterization, Peripheral / Q000379:methods; D003287:Contrast Media / Q000008:administration & dosage; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D006929:Hyperaldosteronism / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013312:Stress, Physiological / Q000502:physiology; D014680:Veins / Q000000981:diagnostic imaging
chemical_list: D003287:Contrast Media; D000450:Aldosterone; D006854:Hydrocortisone
keywords: Adrenal vein sampling; Contrast materials; Primary aldosteronism