title: Evaluation of functional RAGE gene polymorphisms in childhood acute lymphoblastic leukemia-A case-control study from Iran.
abstract: We examined the possible relationship between three RAGE polymorphisms, -429C/T, -374 T/A, and 63-bp deletion, and susceptibility to childhood acute lymphoblastic leukemia (ALL) in an Iranian population. This study included 75 ALL patients and 115 healthy subjects. Genotyping was performed using HEXA-ARMS-polymerase chain reaction. We found no significant association among RAGE gene polymorphisms and the risk for ALL at genotype, allelic and haplotype levels (P > 0.05). The hemoglobin levels were higher in patients with RAGE -374 TT than in the TA carriers (P = 0.019). Our results demonstrated that the RAGE gene variations were not associated with risk of pediatrics ALL.
authors.affiliation: a Genetic of Non-Communicable Disease Research Center, Zahedan University of Medical Sciences , Zahedan , Iran.|b Department of Clinical Biochemistry , School of Medicine, Zahedan University of Medical Sciences , Zahedan , Iran.
authors.forename: Ebrahim
authors.initials: E
authors.lastname: Eskandari-Nasab
authors.affiliation: b Department of Clinical Biochemistry , School of Medicine, Zahedan University of Medical Sciences , Zahedan , Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Hashemi
authors.affiliation: a Genetic of Non-Communicable Disease Research Center, Zahedan University of Medical Sciences , Zahedan , Iran.|b Department of Clinical Biochemistry , School of Medicine, Zahedan University of Medical Sciences , Zahedan , Iran.
authors.forename: Seyed-Shahab-Adin
authors.initials: SS
authors.lastname: Hasani
authors.affiliation: a Genetic of Non-Communicable Disease Research Center, Zahedan University of Medical Sciences , Zahedan , Iran.
authors.forename: Majid
authors.initials: M
authors.lastname: Naderi
authors.affiliation: c Department of Pediatrics , School of Medicine, Zahedan University of Medical Sciences , Zahedan , Iran.
authors.forename: Simin
authors.initials: S
authors.lastname: Sadeghi-Bojd
authors.affiliation: a Genetic of Non-Communicable Disease Research Center, Zahedan University of Medical Sciences , Zahedan , Iran.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Taheri
mesh_terms: D000293:Adolescent; D000951:Antigens, Neoplasm / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006579:Heterozygote; D006801:Humans; D007492:Iran; D008297:Male; D020928:Mitogen-Activated Protein Kinases / Q000235:genetics*; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*
chemical_list: D000951:Antigens, Neoplasm; C498978:MOK protein, human; D020928:Mitogen-Activated Protein Kinases
keywords: RAGE; childhood acute lymphoblastic leukemia; gene polymorphisms