title: The Effect of Aging on the Ventilatory Response to Wearing a Chemical, Biological, Radiological, and Nuclear Hood Respirator at Rest and During Mild Exercise.
abstract: Structural changes in the human body resulting from aging may affect the response to altered levels of O2and CO2. An abnormal ventilatory response to a buildup of CO2in the inspired air due to rebreathing may result in adverse effects, which will impair the individual's ability to function under stress. The purpose of this study was to evaluate the effect of age on the respiratory response to wearing an escape hood at rest and during mild exercise.
  
  
  
  Subjects were seven healthy, young adult males (20-30 years) and seven healthy, middle-aged males (45-65 years). Inspired CO2and O2, breathing pattern (tidal volume [VT] and breathing frequency [F]), and mouth inspiratory and expiratory pressures, were measured at rest and during mild exercise (50 w) while wearing the CAPS 2000 escape hood (Shalon Chemical Industries and Supergum-Rubber and Plastic Technology, Tel Aviv, Israel).
  
  
  
  Resting inspired CO2was higher in the middle-aged group compared with the young group (2.25% ± 0.42% and 1.80% ± 0.34%, respectively; p < 0.05). Breathing pattern in the middle-aged group tended to be shallower and faster compared with the young group (VT: 0.69 ± 0.27 L and 0.79 ± 0.32 L, respectively; F: 14.7 ± 4.0 breaths/min and 12.4 ± 2.8 breaths/min, respectively). During exercise, there was a trend toward a high inspired CO2in the middle-aged group compared with the young group (2.18% ± 0.40% CO2and 1.94% ± 0.70% CO2, respectively). A correlation was found between age and inspired CO2when wearing the escape hood (r2= 0.375; p < 0.05).
  
  
  
  The age-related decrease in pulmonary function, together with the finding in this study of a higher inspired CO2in middle-aged subjects wearing the CAPS 2000, may represent a greater risk for persons of middle age wearing an escape hood.
  
  
  
  On the basis of this study, it would appear reasonable to recommend that new respirators be evaluated on subjects from different age groups, to ensure the safety of both young and old.
authors.affiliation: Israel Naval Medical Institute, Israel Defense Forces Medical Corps, Box 22, Rambam Health Care Campus, P.O. Box 9602, 3109601 Haifa, Israel.
authors.forename: Dror
authors.initials: D
authors.lastname: Ofir
authors.affiliation: Israel Naval Medical Institute, Israel Defense Forces Medical Corps, Box 22, Rambam Health Care Campus, P.O. Box 9602, 3109601 Haifa, Israel.
authors.forename: Yoav
authors.initials: Y
authors.lastname: Yanir
authors.affiliation: Israel Naval Medical Institute, Israel Defense Forces Medical Corps, Box 22, Rambam Health Care Campus, P.O. Box 9602, 3109601 Haifa, Israel.
authors.forename: Mirit
authors.initials: M
authors.lastname: Eynan
authors.affiliation: Israel Naval Medical Institute, Israel Defense Forces Medical Corps, Box 22, Rambam Health Care Campus, P.O. Box 9602, 3109601 Haifa, Israel.
authors.forename: Ben
authors.initials: B
authors.lastname: Aviner
authors.affiliation: Israel Naval Medical Institute, Israel Defense Forces Medical Corps, Box 22, Rambam Health Care Campus, P.O. Box 9602, 3109601 Haifa, Israel.
authors.forename: Adi
authors.initials: A
authors.lastname: Biram
authors.affiliation: Israel Naval Medical Institute, Israel Defense Forces Medical Corps, Box 22, Rambam Health Care Campus, P.O. Box 9602, 3109601 Haifa, Israel.
authors.forename: Michael
authors.initials: M
authors.lastname: Mullokandov
authors.affiliation: Israel Naval Medical Institute, Israel Defense Forces Medical Corps, Box 22, Rambam Health Care Campus, P.O. Box 9602, 3109601 Haifa, Israel.
authors.forename: Ronen
authors.initials: R
authors.lastname: Bar
authors.affiliation: Israel Naval Medical Institute, Israel Defense Forces Medical Corps, Box 22, Rambam Health Care Campus, P.O. Box 9602, 3109601 Haifa, Israel.
authors.forename: Yehuda
authors.initials: Y
authors.lastname: Arieli
mesh_terms: D000328:Adult; D000375:Aging / Q000502:physiology*; D001784:Blood Gas Analysis / Q000379:methods; D002245:Carbon Dioxide / Q000032:analysis; D017079:Exercise Tolerance / Q000502:physiology*; D006801:Humans; D007557:Israel; D008297:Male; D013058:Mass Spectrometry / Q000379:methods; D008875:Middle Aged; D008889:Military Personnel / Q000706:statistics & numerical data; D010101:Oxygen Consumption / Q000502:physiology; D012119:Respiration; D012129:Respiratory Function Tests / Q000379:methods; D012134:Respiratory Protective Devices / Q000009:adverse effects* / Q000706:statistics & numerical data; D014691:Ventilation / Q000706:statistics & numerical data*
chemical_list: D002245:Carbon Dioxide