title: Family-Based Association Study of rs17300539 and rs12495941 Polymorphism in Adiponectin Gene and Polycystic Ovary Syndrome in a Chinese Population.
abstract: BACKGROUND Polycystic ovary syndrome (PCOS) is a complex disease that has both genetic and environmental components. Adiponectin plays an important role in the regulation of insulin sensitivity and insulin resistance (IR) in PCOS. The aim of this study was to determine 2 single-nucleotide polymorphisms (SNPs) variants (rs12495941 and rs17300539) of the adiponectin gene (ADIPOQ) in polycystic ovary syndrome (PCOS) families. MATERIAL AND METHODS We recruited 197 PCOS probands, their biological parents, and 192 controls. Anthropometric variables, including hip circumference (HC) and waist circumference (WC), were measured in all subjects during their first visit to the outpatient department. Serum T, FBG, FINS, TC, TG, LDL, and HDL levels were measured. PCOS patients were divided into 2 groups based on BMI: group A (BMI <25 kg/m²) and group B (BMI ≥25 kg/m²). Parents of PCOS were accordingly categorized into group C and group D (fathers), and group E and group F (mothers). The associations among ADIPOQ rs12495941, rs17300539, and PCOS were analyzed using the transmission disequilibrium test (TDT). RESULTS A significant association was found between SNP rs17300539 and PCOS in our Chinese population. The levels of TG and FINS and the genotype frequencies of rs17300539 are significantly different between overweight and lean PCOS. No significant association was detected for rs12495941. CONCLUSIONS TDT confirms that rs17300539 of ADIPOQ is strongly associated with the risk of PCOS in a Chinese Han population, but rs12495941 of ADIPOQ is not associated with the occurrence of PCOS.
authors.affiliation: Department of Physiology, Taishan Medical University, Taian, Shandong, China (mainland).
authors.forename: Xianchang
authors.initials: X
authors.lastname: Sun
authors.affiliation: Department of Gynaecology, The Central Hospital of Taian, Taian, Shandong, China (mainland).
authors.forename: Xingguo
authors.initials: X
authors.lastname: Wu
authors.affiliation: Center for Reproductive Medicine, Affiliated Hospital of Taishan Medical University, Taian, Shandong, China (mainland).
authors.forename: Yunmin
authors.initials: Y
authors.lastname: Duan
authors.affiliation: Department of Gynaecology, Affiliated Hospital of Taishan Medical University, Taian, Shandong, China (mainland).
authors.forename: Guanghai
authors.initials: G
authors.lastname: Liu
authors.affiliation: Center for Reproductive Medicine, The Central Hospital of Taian, Taian, Shandong, China (mainland).
authors.forename: Xinyan
authors.initials: X
authors.lastname: Yu
authors.affiliation: Center for Reproductive Medicine, Affiliated Hospital of Taishan Medical University, Taian, Shandong, China (mainland).
authors.forename: Wenjuan
authors.initials: W
authors.lastname: Zhang
mesh_terms: D052242:Adiponectin / Q000235:genetics* / Q000378:metabolism; D000328:Adult; D044466:Asian People / Q000235:genetics; D001835:Body Weight; D002681:China; D005195:Family Relations; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D050177:Overweight / Q000235:genetics / Q000378:metabolism; D011085:Polycystic Ovary Syndrome / Q000235:genetics* / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D007328:Insulin