title: Dual role of histamine on microglia-induced neurodegeneration.
abstract: Several hypotheses have been raised about the dual role of histamine in neurological disorders, and evidences have shown its crucial involvement in the modulation of microglia-mediated neuroinflammation. Previously, we reported that the administration of histamine induces a deleterious effect by promoting a pro-inflammatory phenotype on microglia that in turn compromises dopaminergic neuronal survival. Contrary, under lipopolysaccharide challenge, histamine inhibits the injurious effect of microglia-mediated inflammation, protecting dopaminergic neurons, suggesting that the modulation of microglial activity is dependent on the environmental context. Thus, histamine and/or histamine receptor agonists may serve to develop new therapeutic approaches to overcome neurodegenerative disorders.
authors.affiliation: Health Sciences Research Centre, Faculty of Health Sciences, University of Beira Interior, Covilhã, Portugal.
authors.forename: S
authors.initials: S
authors.lastname: Barata-Antunes
authors.affiliation: Health Sciences Research Centre, Faculty of Health Sciences, University of Beira Interior, Covilhã, Portugal.
authors.forename: A C
authors.initials: AC
authors.lastname: Cristóvão
authors.affiliation: Health Sciences Research Centre, Faculty of Health Sciences, University of Beira Interior, Covilhã, Portugal.
authors.forename: J
authors.initials: J
authors.lastname: Pires
authors.affiliation: Health Sciences Research Centre, Faculty of Health Sciences, University of Beira Interior, Covilhã, Portugal.
authors.forename: S M
authors.initials: SM
authors.lastname: Rocha
authors.affiliation: Health Sciences Research Centre, Faculty of Health Sciences, University of Beira Interior, Covilhã, Portugal. Electronic address: libernardino@fcsaude.ubi.pt.
authors.forename: L
authors.initials: L
authors.lastname: Bernardino
mesh_terms: D000818:Animals; D059290:Dopaminergic Neurons / Q000276:immunology* / Q000473:pathology; D006632:Histamine / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000276:immunology* / Q000473:pathology; D008070:Lipopolysaccharides / Q000276:immunology; D017628:Microglia / Q000276:immunology* / Q000473:pathology; D019636:Neurodegenerative Diseases / Q000276:immunology* / Q000473:pathology; D010300:Parkinson Disease / Q000276:immunology / Q000473:pathology
chemical_list: D008070:Lipopolysaccharides; D006632:Histamine
keywords: Histamine; Lipopolysaccharide; Microglia; Neurodegeneration; Neuroinflammation; Parkinson's disease