title: The discovery of Alzheimer-causing mutations in the APP gene and the formulation of the "amyloid cascade hypothesis".
abstract: The cloning of APP and genetic analysis of families with Alzheimer's disease were both reported in 1987 and much present work on the disease is based upon the foundations laid at that time. Progress was not smooth, however, and many errors were made. In this memoir, I lay out both the progress and the errors.
authors.affiliation: Reta Lila Weston Research Laboratories and Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
authors.forename: John
authors.initials: J
authors.lastname: Hardy
mesh_terms: D000544:Alzheimer Disease / Q000175:diagnosis / Q000235:genetics* / Q000266:history / Q000473:pathology; D016564:Amyloid beta-Protein Precursor / Q000235:genetics*; D016477:Artifacts; D002891:Chromosomes, Human, Pair 21 / Q000737:chemistry*; D004314:Down Syndrome / Q000175:diagnosis / Q000235:genetics* / Q000266:history / Q000473:pathology; D020440:Gene Duplication; D015870:Gene Expression; D005819:Genetic Markers; D049673:History, 20th Century; D006801:Humans
chemical_list: C545487:APP protein, human; D016564:Amyloid beta-Protein Precursor; D005819:Genetic Markers
keywords: 
  APP
  ; Alzheimer's disease; Down syndrome; amyloid; genetics