title: Postinduction Minimal Residual Disease Predicts Outcome and Benefit From Allogeneic Stem Cell Transplantation in Acute Myeloid Leukemia With NPM1 Mutation: A Study by the Acute Leukemia French Association Group.
abstract: Purpose This study assessed the prognostic impact of postinduction NPM1-mutated ( NPM1m) minimal residual disease (MRD) in young adult patients (age, 18 to 60 years) with acute myeloid leukemia, and addressed the question of whether NPM1m MRD may be used as a predictive factor of allogeneic stem cell transplantation (ASCT) benefit. Patients and Methods Among 229 patients with NPM1m who were treated in the Acute Leukemia French Association 0702 (ALFA-0702) trial, MRD evaluation was available in 152 patients in first remission. Patients with nonfavorable AML according to the European LeukemiaNet (ELN) classification were eligible for ASCT in first remission. Results After induction therapy, patients who did not achieve a 4-log reduction in NPM1m peripheral blood-MRD (PB-MRD) had a higher cumulative incidence of relapse (subhazard ratio [SHR], 5.83; P < .001) and a shorter overall survival (OS; hazard ratio [HR], 10.99; P < .001). In multivariable analysis, an abnormal karyotype, the presence of FLT3-internal tandem duplication (ITD), and a < 4-log reduction in PB-MRD were significantly associated with a higher relapse incidence and shorter OS. In the subset of patients with FLT3-ITD, only age, white blood cell count, and < 4-log reduction in PB-MRD, but not FLT3-ITD allelic ratio, remained of significant prognostic value. In these patients with nonfavorable AML according to European LeukemiaNet, disease-free survival and OS were significantly improved by ASCT in those with a < 4-log reduction in PB-MRD. This benefit was not observed in those with a > 4-log reduction in PB-MRD, with a significant interaction between ASCT effect and PB-MRD response ( P = .024 and .027 for disease-free survival and OS, respectively). Conclusion Our study supports the strong prognostic significance of early NPM1m PB-MRD, independent of the cytogenetic and molecular context. Moreover, NPM1m PB-MRD may be used as a predictive factor for ASCT indication.
authors.affiliation: Marie Balsat, Xavier Thomas, and Sandrine Hayette, Centre Hospitalier Lyon Sud, Pierre Benite; Aline Renneville, Alice Marceau, Olivier Nibourel, Céline Rodriguez, and Claude Preudhomme, CHRU of Lille; Aline Renneville, Alice Marceau, Olivier Nibourel, and Claude Preudhomme, Cancer Research Institute of Lille and Université Lille; and Céline Berthon, Claude Huriez Hospital, Lille; Stéphane de Botton, Institut Gustave Roussy, Villejuif; Denis Caillot, Dijon University Hospital, Dijon; Emilie Lemasle, Henri-Becquerel Center, Rouen; Jean-Pierre Marolleau, Amiens University Hospital, Amiens; Emmanuel Raffoux, Hervé Dombret, Jean-Michel Cayuela, Marie Magdeleine Coudé, Karine Celli-Lebras, and Nicolas Boissel, Hôpital Saint-Louis, AP-HP; Emmanuel Raffoux, Herve Dombret, and Nicolas Boissel, University 7 Paris Diderot; and Thorsten Braun, Hôpital Avicennes, AP-HP, Paris; Arnaud Pigneux, Haut-Leveque Hospital, Pessac; Norbert Vey, Paoli-Calmette Institute, Marseille; and Christine Terre, Hôpital de Versailles, Le Chesnay, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Balsat
authors.affiliation: Marie Balsat, Xavier Thomas, and Sandrine Hayette, Centre Hospitalier Lyon Sud, Pierre Benite; Aline Renneville, Alice Marceau, Olivier Nibourel, Céline Rodriguez, and Claude Preudhomme, CHRU of Lille; Aline Renneville, Alice Marceau, Olivier Nibourel, and Claude Preudhomme, Cancer Research Institute of Lille and Université Lille; and Céline Berthon, Claude Huriez Hospital, Lille; Stéphane de Botton, Institut Gustave Roussy, Villejuif; Denis Caillot, Dijon University Hospital, Dijon; Emilie Lemasle, Henri-Becquerel Center, Rouen; Jean-Pierre Marolleau, Amiens University Hospital, Amiens; Emmanuel Raffoux, Hervé Dombret, Jean-Michel Cayuela, Marie Magdeleine Coudé, Karine Celli-Lebras, and Nicolas Boissel, Hôpital Saint-Louis, AP-HP; Emmanuel Raffoux, Herve Dombret, and Nicolas Boissel, University 7 Paris Diderot; and Thorsten Braun, Hôpital Avicennes, AP-HP, Paris; Arnaud Pigneux, Haut-Leveque Hospital, Pessac; Norbert Vey, Paoli-Calmette Institute, Marseille; and Christine Terre, Hôpital de Versailles, Le Chesnay, France.
authors.forename: Aline
authors.initials: A
authors.lastname: Renneville
authors.affiliation: Marie Balsat, Xavier Thomas, and Sandrine Hayette, Centre Hospitalier Lyon Sud, Pierre Benite; Aline Renneville, Alice Marceau, Olivier Nibourel, Céline Rodriguez, and Claude Preudhomme, CHRU of Lille; Aline Renneville, Alice Marceau, Olivier Nibourel, and Claude Preudhomme, Cancer Research Institute of Lille and Université Lille; and Céline Berthon, Claude Huriez Hospital, Lille; Stéphane de Botton, Institut Gustave Roussy, Villejuif; Denis Caillot, Dijon University Hospital, Dijon; Emilie Lemasle, Henri-Becquerel Center, Rouen; Jean-Pierre Marolleau, Amiens University Hospital, Amiens; Emmanuel Raffoux, Hervé Dombret, Jean-Michel Cayuela, Marie Magdeleine Coudé, Karine Celli-Lebras, and Nicolas Boissel, Hôpital Saint-Louis, AP-HP; Emmanuel Raffoux, Herve Dombret, and Nicolas Boissel, University 7 Paris Diderot; and Thorsten Braun, Hôpital Avicennes, AP-HP, Paris; Arnaud Pigneux, Haut-Leveque Hospital, Pessac; Norbert Vey, Paoli-Calmette Institute, Marseille; and Christine Terre, Hôpital de Versailles, Le Chesnay, France.
authors.forename: Xavier
authors.initials: X
authors.lastname: Thomas
authors.affiliation: Marie Balsat, Xavier Thomas, and Sandrine Hayette, Centre Hospitalier Lyon Sud, Pierre Benite; Aline Renneville, Alice Marceau, Olivier Nibourel, Céline Rodriguez, and Claude Preudhomme, CHRU of Lille; Aline Renneville, Alice Marceau, Olivier Nibourel, and Claude Preudhomme, Cancer Research Institute of Lille and Université Lille; and Céline Berthon, Claude Huriez Hospital, Lille; Stéphane de Botton, Institut Gustave Roussy, Villejuif; Denis Caillot, Dijon University Hospital, Dijon; Emilie Lemasle, Henri-Becquerel Center, Rouen; Jean-Pierre Marolleau, Amiens University Hospital, Amiens; Emmanuel Raffoux, Hervé Dombret, Jean-Michel Cayuela, Marie Magdeleine Coudé, Karine Celli-Lebras, and Nicolas Boissel, Hôpital Saint-Louis, AP-HP; Emmanuel Raffoux, Herve Dombret, and Nicolas Boissel, University 7 Paris Diderot; and Thorsten Braun, Hôpital Avicennes, AP-HP, Paris; Arnaud Pigneux, Haut-Leveque Hospital, Pessac; Norbert Vey, Paoli-Calmette Institute, Marseille; and Christine Terre, Hôpital de Versailles, Le Chesnay, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: de Botton
authors.affiliation: Marie Balsat, Xavier Thomas, and Sandrine Hayette, Centre Hospitalier Lyon Sud, Pierre Benite; Aline Renneville, Alice Marceau, Olivier Nibourel, Céline Rodriguez, and Claude Preudhomme, CHRU of Lille; Aline Renneville, Alice Marceau, Olivier Nibourel, and Claude Preudhomme, Cancer Research Institute of Lille and Université Lille; and Céline Berthon, Claude Huriez Hospital, Lille; Stéphane de Botton, Institut Gustave Roussy, Villejuif; Denis Caillot, Dijon University Hospital, Dijon; Emilie Lemasle, Henri-Becquerel Center, Rouen; Jean-Pierre Marolleau, Amiens University Hospital, Amiens; Emmanuel Raffoux, Hervé Dombret, Jean-Michel Cayuela, Marie Magdeleine Coudé, Karine Celli-Lebras, and Nicolas Boissel, Hôpital Saint-Louis, AP-HP; Emmanuel Raffoux, Herve Dombret, and Nicolas Boissel, University 7 Paris Diderot; and Thorsten Braun, Hôpital Avicennes, AP-HP, Paris; Arnaud Pigneux, Haut-Leveque Hospital, Pessac; Norbert Vey, Paoli-Calmette Institute, Marseille; and Christine Terre, Hôpital de Versailles, Le Chesnay, France.
authors.forename: Denis
authors.initials: D
authors.lastname: Caillot
authors.affiliation: Marie Balsat, Xavier Thomas, and Sandrine Hayette, Centre Hospitalier Lyon Sud, Pierre Benite; Aline Renneville, Alice Marceau, Olivier Nibourel, Céline Rodriguez, and Claude Preudhomme, CHRU of Lille; Aline Renneville, Alice Marceau, Olivier Nibourel, and Claude Preudhomme, Cancer Research Institute of Lille and Université Lille; and Céline Berthon, Claude Huriez Hospital, Lille; Stéphane de Botton, Institut Gustave Roussy, Villejuif; Denis Caillot, Dijon University Hospital, Dijon; Emilie Lemasle, Henri-Becquerel Center, Rouen; Jean-Pierre Marolleau, Amiens University Hospital, Amiens; Emmanuel Raffoux, Hervé Dombret, Jean-Michel Cayuela, Marie Magdeleine Coudé, Karine Celli-Lebras, and Nicolas Boissel, Hôpital Saint-Louis, AP-HP; Emmanuel Raffoux, Herve Dombret, and Nicolas Boissel, University 7 Paris Diderot; and Thorsten Braun, Hôpital Avicennes, AP-HP, Paris; Arnaud Pigneux, Haut-Leveque Hospital, Pessac; Norbert Vey, Paoli-Calmette Institute, Marseille; and Christine Terre, Hôpital de Versailles, Le Chesnay, France.
authors.forename: Alice
authors.initials: A
authors.lastname: Marceau
authors.affiliation: Marie Balsat, Xavier Thomas, and Sandrine Hayette, Centre Hospitalier Lyon Sud, Pierre Benite; Aline Renneville, Alice Marceau, Olivier Nibourel, Céline Rodriguez, and Claude Preudhomme, CHRU of Lille; Aline Renneville, Alice Marceau, Olivier Nibourel, and Claude Preudhomme, Cancer Research Institute of Lille and Université Lille; and Céline Berthon, Claude Huriez Hospital, Lille; Stéphane de Botton, Institut Gustave Roussy, Villejuif; Denis Caillot, Dijon University Hospital, Dijon; Emilie Lemasle, Henri-Becquerel Center, Rouen; Jean-Pierre Marolleau, Amiens University Hospital, Amiens; Emmanuel Raffoux, Hervé Dombret, Jean-Michel Cayuela, Marie Magdeleine Coudé, Karine Celli-Lebras, and Nicolas Boissel, Hôpital Saint-Louis, AP-HP; Emmanuel Raffoux, Herve Dombret, and Nicolas Boissel, University 7 Paris Diderot; and Thorsten Braun, Hôpital Avicennes, AP-HP, Paris; Arnaud Pigneux, Haut-Leveque Hospital, Pessac; Norbert Vey, Paoli-Calmette Institute, Marseille; and Christine Terre, Hôpital de Versailles, Le Chesnay, France.
authors.forename: Emilie
authors.initials: E
authors.lastname: Lemasle
authors.affiliation: Marie Balsat, Xavier Thomas, and Sandrine Hayette, Centre Hospitalier Lyon Sud, Pierre Benite; Aline Renneville, Alice Marceau, Olivier Nibourel, Céline Rodriguez, and Claude Preudhomme, CHRU of Lille; Aline Renneville, Alice Marceau, Olivier Nibourel, and Claude Preudhomme, Cancer Research Institute of Lille and Université Lille; and Céline Berthon, Claude Huriez Hospital, Lille; Stéphane de Botton, Institut Gustave Roussy, Villejuif; Denis Caillot, Dijon University Hospital, Dijon; Emilie Lemasle, Henri-Becquerel Center, Rouen; Jean-Pierre Marolleau, Amiens University Hospital, Amiens; Emmanuel Raffoux, Hervé Dombret, Jean-Michel Cayuela, Marie Magdeleine Coudé, Karine Celli-Lebras, and Nicolas Boissel, Hôpital Saint-Louis, AP-HP; Emmanuel Raffoux, Herve Dombret, and Nicolas Boissel, University 7 Paris Diderot; and Thorsten Braun, Hôpital Avicennes, AP-HP, Paris; Arnaud Pigneux, Haut-Leveque Hospital, Pessac; Norbert Vey, Paoli-Calmette Institute, Marseille; and Christine Terre, Hôpital de Versailles, Le Chesnay, France.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Marolleau
authors.affiliation: Marie Balsat, Xavier Thomas, and Sandrine Hayette, Centre Hospitalier Lyon Sud, Pierre Benite; Aline Renneville, Alice Marceau, Olivier Nibourel, Céline Rodriguez, and Claude Preudhomme, CHRU of Lille; Aline Renneville, Alice Marceau, Olivier Nibourel, and Claude Preudhomme, Cancer Research Institute of Lille and Université Lille; and Céline Berthon, Claude Huriez Hospital, Lille; Stéphane de Botton, Institut Gustave Roussy, Villejuif; Denis Caillot, Dijon University Hospital, Dijon; Emilie Lemasle, Henri-Becquerel Center, Rouen; Jean-Pierre Marolleau, Amiens University Hospital, Amiens; Emmanuel Raffoux, Hervé Dombret, Jean-Michel Cayuela, Marie Magdeleine Coudé, Karine Celli-Lebras, and Nicolas Boissel, Hôpital Saint-Louis, AP-HP; Emmanuel Raffoux, Herve Dombret, and Nicolas Boissel, University 7 Paris Diderot; and Thorsten Braun, Hôpital Avicennes, AP-HP, Paris; Arnaud Pigneux, Haut-Leveque Hospital, Pessac; Norbert Vey, Paoli-Calmette Institute, Marseille; and Christine Terre, Hôpital de Versailles, Le Chesnay, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Nibourel
authors.affiliation: Marie Balsat, Xavier Thomas, and Sandrine Hayette, Centre Hospitalier Lyon Sud, Pierre Benite; Aline Renneville, Alice Marceau, Olivier Nibourel, Céline Rodriguez, and Claude Preudhomme, CHRU of Lille; Aline Renneville, Alice Marceau, Olivier Nibourel, and Claude Preudhomme, Cancer Research Institute of Lille and Université Lille; and Céline Berthon, Claude Huriez Hospital, Lille; Stéphane de Botton, Institut Gustave Roussy, Villejuif; Denis Caillot, Dijon University Hospital, Dijon; Emilie Lemasle, Henri-Becquerel Center, Rouen; Jean-Pierre Marolleau, Amiens University Hospital, Amiens; Emmanuel Raffoux, Hervé Dombret, Jean-Michel Cayuela, Marie Magdeleine Coudé, Karine Celli-Lebras, and Nicolas Boissel, Hôpital Saint-Louis, AP-HP; Emmanuel Raffoux, Herve Dombret, and Nicolas Boissel, University 7 Paris Diderot; and Thorsten Braun, Hôpital Avicennes, AP-HP, Paris; Arnaud Pigneux, Haut-Leveque Hospital, Pessac; Norbert Vey, Paoli-Calmette Institute, Marseille; and Christine Terre, Hôpital de Versailles, Le Chesnay, France.
authors.forename: Céline
authors.initials: C
authors.lastname: Berthon
authors.affiliation: Marie Balsat, Xavier Thomas, and Sandrine Hayette, Centre Hospitalier Lyon Sud, Pierre Benite; Aline Renneville, Alice Marceau, Olivier Nibourel, Céline Rodriguez, and Claude Preudhomme, CHRU of Lille; Aline Renneville, Alice Marceau, Olivier Nibourel, and Claude Preudhomme, Cancer Research Institute of Lille and Université Lille; and Céline Berthon, Claude Huriez Hospital, Lille; Stéphane de Botton, Institut Gustave Roussy, Villejuif; Denis Caillot, Dijon University Hospital, Dijon; Emilie Lemasle, Henri-Becquerel Center, Rouen; Jean-Pierre Marolleau, Amiens University Hospital, Amiens; Emmanuel Raffoux, Hervé Dombret, Jean-Michel Cayuela, Marie Magdeleine Coudé, Karine Celli-Lebras, and Nicolas Boissel, Hôpital Saint-Louis, AP-HP; Emmanuel Raffoux, Herve Dombret, and Nicolas Boissel, University 7 Paris Diderot; and Thorsten Braun, Hôpital Avicennes, AP-HP, Paris; Arnaud Pigneux, Haut-Leveque Hospital, Pessac; Norbert Vey, Paoli-Calmette Institute, Marseille; and Christine Terre, Hôpital de Versailles, Le Chesnay, France.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Raffoux
authors.affiliation: Marie Balsat, Xavier Thomas, and Sandrine Hayette, Centre Hospitalier Lyon Sud, Pierre Benite; Aline Renneville, Alice Marceau, Olivier Nibourel, Céline Rodriguez, and Claude Preudhomme, CHRU of Lille; Aline Renneville, Alice Marceau, Olivier Nibourel, and Claude Preudhomme, Cancer Research Institute of Lille and Université Lille; and Céline Berthon, Claude Huriez Hospital, Lille; Stéphane de Botton, Institut Gustave Roussy, Villejuif; Denis Caillot, Dijon University Hospital, Dijon; Emilie Lemasle, Henri-Becquerel Center, Rouen; Jean-Pierre Marolleau, Amiens University Hospital, Amiens; Emmanuel Raffoux, Hervé Dombret, Jean-Michel Cayuela, Marie Magdeleine Coudé, Karine Celli-Lebras, and Nicolas Boissel, Hôpital Saint-Louis, AP-HP; Emmanuel Raffoux, Herve Dombret, and Nicolas Boissel, University 7 Paris Diderot; and Thorsten Braun, Hôpital Avicennes, AP-HP, Paris; Arnaud Pigneux, Haut-Leveque Hospital, Pessac; Norbert Vey, Paoli-Calmette Institute, Marseille; and Christine Terre, Hôpital de Versailles, Le Chesnay, France.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Pigneux
authors.affiliation: Marie Balsat, Xavier Thomas, and Sandrine Hayette, Centre Hospitalier Lyon Sud, Pierre Benite; Aline Renneville, Alice Marceau, Olivier Nibourel, Céline Rodriguez, and Claude Preudhomme, CHRU of Lille; Aline Renneville, Alice Marceau, Olivier Nibourel, and Claude Preudhomme, Cancer Research Institute of Lille and Université Lille; and Céline Berthon, Claude Huriez Hospital, Lille; Stéphane de Botton, Institut Gustave Roussy, Villejuif; Denis Caillot, Dijon University Hospital, Dijon; Emilie Lemasle, Henri-Becquerel Center, Rouen; Jean-Pierre Marolleau, Amiens University Hospital, Amiens; Emmanuel Raffoux, Hervé Dombret, Jean-Michel Cayuela, Marie Magdeleine Coudé, Karine Celli-Lebras, and Nicolas Boissel, Hôpital Saint-Louis, AP-HP; Emmanuel Raffoux, Herve Dombret, and Nicolas Boissel, University 7 Paris Diderot; and Thorsten Braun, Hôpital Avicennes, AP-HP, Paris; Arnaud Pigneux, Haut-Leveque Hospital, Pessac; Norbert Vey, Paoli-Calmette Institute, Marseille; and Christine Terre, Hôpital de Versailles, Le Chesnay, France.
authors.forename: Céline
authors.initials: C
authors.lastname: Rodriguez
authors.affiliation: Marie Balsat, Xavier Thomas, and Sandrine Hayette, Centre Hospitalier Lyon Sud, Pierre Benite; Aline Renneville, Alice Marceau, Olivier Nibourel, Céline Rodriguez, and Claude Preudhomme, CHRU of Lille; Aline Renneville, Alice Marceau, Olivier Nibourel, and Claude Preudhomme, Cancer Research Institute of Lille and Université Lille; and Céline Berthon, Claude Huriez Hospital, Lille; Stéphane de Botton, Institut Gustave Roussy, Villejuif; Denis Caillot, Dijon University Hospital, Dijon; Emilie Lemasle, Henri-Becquerel Center, Rouen; Jean-Pierre Marolleau, Amiens University Hospital, Amiens; Emmanuel Raffoux, Hervé Dombret, Jean-Michel Cayuela, Marie Magdeleine Coudé, Karine Celli-Lebras, and Nicolas Boissel, Hôpital Saint-Louis, AP-HP; Emmanuel Raffoux, Herve Dombret, and Nicolas Boissel, University 7 Paris Diderot; and Thorsten Braun, Hôpital Avicennes, AP-HP, Paris; Arnaud Pigneux, Haut-Leveque Hospital, Pessac; Norbert Vey, Paoli-Calmette Institute, Marseille; and Christine Terre, Hôpital de Versailles, Le Chesnay, France.
authors.forename: Norbert
authors.initials: N
authors.lastname: Vey
authors.affiliation: Marie Balsat, Xavier Thomas, and Sandrine Hayette, Centre Hospitalier Lyon Sud, Pierre Benite; Aline Renneville, Alice Marceau, Olivier Nibourel, Céline Rodriguez, and Claude Preudhomme, CHRU of Lille; Aline Renneville, Alice Marceau, Olivier Nibourel, and Claude Preudhomme, Cancer Research Institute of Lille and Université Lille; and Céline Berthon, Claude Huriez Hospital, Lille; Stéphane de Botton, Institut Gustave Roussy, Villejuif; Denis Caillot, Dijon University Hospital, Dijon; Emilie Lemasle, Henri-Becquerel Center, Rouen; Jean-Pierre Marolleau, Amiens University Hospital, Amiens; Emmanuel Raffoux, Hervé Dombret, Jean-Michel Cayuela, Marie Magdeleine Coudé, Karine Celli-Lebras, and Nicolas Boissel, Hôpital Saint-Louis, AP-HP; Emmanuel Raffoux, Herve Dombret, and Nicolas Boissel, University 7 Paris Diderot; and Thorsten Braun, Hôpital Avicennes, AP-HP, Paris; Arnaud Pigneux, Haut-Leveque Hospital, Pessac; Norbert Vey, Paoli-Calmette Institute, Marseille; and Christine Terre, Hôpital de Versailles, Le Chesnay, France.
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Cayuela
authors.affiliation: Marie Balsat, Xavier Thomas, and Sandrine Hayette, Centre Hospitalier Lyon Sud, Pierre Benite; Aline Renneville, Alice Marceau, Olivier Nibourel, Céline Rodriguez, and Claude Preudhomme, CHRU of Lille; Aline Renneville, Alice Marceau, Olivier Nibourel, and Claude Preudhomme, Cancer Research Institute of Lille and Université Lille; and Céline Berthon, Claude Huriez Hospital, Lille; Stéphane de Botton, Institut Gustave Roussy, Villejuif; Denis Caillot, Dijon University Hospital, Dijon; Emilie Lemasle, Henri-Becquerel Center, Rouen; Jean-Pierre Marolleau, Amiens University Hospital, Amiens; Emmanuel Raffoux, Hervé Dombret, Jean-Michel Cayuela, Marie Magdeleine Coudé, Karine Celli-Lebras, and Nicolas Boissel, Hôpital Saint-Louis, AP-HP; Emmanuel Raffoux, Herve Dombret, and Nicolas Boissel, University 7 Paris Diderot; and Thorsten Braun, Hôpital Avicennes, AP-HP, Paris; Arnaud Pigneux, Haut-Leveque Hospital, Pessac; Norbert Vey, Paoli-Calmette Institute, Marseille; and Christine Terre, Hôpital de Versailles, Le Chesnay, France.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Hayette
authors.affiliation: Marie Balsat, Xavier Thomas, and Sandrine Hayette, Centre Hospitalier Lyon Sud, Pierre Benite; Aline Renneville, Alice Marceau, Olivier Nibourel, Céline Rodriguez, and Claude Preudhomme, CHRU of Lille; Aline Renneville, Alice Marceau, Olivier Nibourel, and Claude Preudhomme, Cancer Research Institute of Lille and Université Lille; and Céline Berthon, Claude Huriez Hospital, Lille; Stéphane de Botton, Institut Gustave Roussy, Villejuif; Denis Caillot, Dijon University Hospital, Dijon; Emilie Lemasle, Henri-Becquerel Center, Rouen; Jean-Pierre Marolleau, Amiens University Hospital, Amiens; Emmanuel Raffoux, Hervé Dombret, Jean-Michel Cayuela, Marie Magdeleine Coudé, Karine Celli-Lebras, and Nicolas Boissel, Hôpital Saint-Louis, AP-HP; Emmanuel Raffoux, Herve Dombret, and Nicolas Boissel, University 7 Paris Diderot; and Thorsten Braun, Hôpital Avicennes, AP-HP, Paris; Arnaud Pigneux, Haut-Leveque Hospital, Pessac; Norbert Vey, Paoli-Calmette Institute, Marseille; and Christine Terre, Hôpital de Versailles, Le Chesnay, France.
authors.forename: Thorsten
authors.initials: T
authors.lastname: Braun
authors.affiliation: Marie Balsat, Xavier Thomas, and Sandrine Hayette, Centre Hospitalier Lyon Sud, Pierre Benite; Aline Renneville, Alice Marceau, Olivier Nibourel, Céline Rodriguez, and Claude Preudhomme, CHRU of Lille; Aline Renneville, Alice Marceau, Olivier Nibourel, and Claude Preudhomme, Cancer Research Institute of Lille and Université Lille; and Céline Berthon, Claude Huriez Hospital, Lille; Stéphane de Botton, Institut Gustave Roussy, Villejuif; Denis Caillot, Dijon University Hospital, Dijon; Emilie Lemasle, Henri-Becquerel Center, Rouen; Jean-Pierre Marolleau, Amiens University Hospital, Amiens; Emmanuel Raffoux, Hervé Dombret, Jean-Michel Cayuela, Marie Magdeleine Coudé, Karine Celli-Lebras, and Nicolas Boissel, Hôpital Saint-Louis, AP-HP; Emmanuel Raffoux, Herve Dombret, and Nicolas Boissel, University 7 Paris Diderot; and Thorsten Braun, Hôpital Avicennes, AP-HP, Paris; Arnaud Pigneux, Haut-Leveque Hospital, Pessac; Norbert Vey, Paoli-Calmette Institute, Marseille; and Christine Terre, Hôpital de Versailles, Le Chesnay, France.
authors.forename: Marie Magdeleine
authors.initials: MM
authors.lastname: Coudé
authors.affiliation: Marie Balsat, Xavier Thomas, and Sandrine Hayette, Centre Hospitalier Lyon Sud, Pierre Benite; Aline Renneville, Alice Marceau, Olivier Nibourel, Céline Rodriguez, and Claude Preudhomme, CHRU of Lille; Aline Renneville, Alice Marceau, Olivier Nibourel, and Claude Preudhomme, Cancer Research Institute of Lille and Université Lille; and Céline Berthon, Claude Huriez Hospital, Lille; Stéphane de Botton, Institut Gustave Roussy, Villejuif; Denis Caillot, Dijon University Hospital, Dijon; Emilie Lemasle, Henri-Becquerel Center, Rouen; Jean-Pierre Marolleau, Amiens University Hospital, Amiens; Emmanuel Raffoux, Hervé Dombret, Jean-Michel Cayuela, Marie Magdeleine Coudé, Karine Celli-Lebras, and Nicolas Boissel, Hôpital Saint-Louis, AP-HP; Emmanuel Raffoux, Herve Dombret, and Nicolas Boissel, University 7 Paris Diderot; and Thorsten Braun, Hôpital Avicennes, AP-HP, Paris; Arnaud Pigneux, Haut-Leveque Hospital, Pessac; Norbert Vey, Paoli-Calmette Institute, Marseille; and Christine Terre, Hôpital de Versailles, Le Chesnay, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Terre
authors.affiliation: Marie Balsat, Xavier Thomas, and Sandrine Hayette, Centre Hospitalier Lyon Sud, Pierre Benite; Aline Renneville, Alice Marceau, Olivier Nibourel, Céline Rodriguez, and Claude Preudhomme, CHRU of Lille; Aline Renneville, Alice Marceau, Olivier Nibourel, and Claude Preudhomme, Cancer Research Institute of Lille and Université Lille; and Céline Berthon, Claude Huriez Hospital, Lille; Stéphane de Botton, Institut Gustave Roussy, Villejuif; Denis Caillot, Dijon University Hospital, Dijon; Emilie Lemasle, Henri-Becquerel Center, Rouen; Jean-Pierre Marolleau, Amiens University Hospital, Amiens; Emmanuel Raffoux, Hervé Dombret, Jean-Michel Cayuela, Marie Magdeleine Coudé, Karine Celli-Lebras, and Nicolas Boissel, Hôpital Saint-Louis, AP-HP; Emmanuel Raffoux, Herve Dombret, and Nicolas Boissel, University 7 Paris Diderot; and Thorsten Braun, Hôpital Avicennes, AP-HP, Paris; Arnaud Pigneux, Haut-Leveque Hospital, Pessac; Norbert Vey, Paoli-Calmette Institute, Marseille; and Christine Terre, Hôpital de Versailles, Le Chesnay, France.
authors.forename: Karine
authors.initials: K
authors.lastname: Celli-Lebras
authors.affiliation: Marie Balsat, Xavier Thomas, and Sandrine Hayette, Centre Hospitalier Lyon Sud, Pierre Benite; Aline Renneville, Alice Marceau, Olivier Nibourel, Céline Rodriguez, and Claude Preudhomme, CHRU of Lille; Aline Renneville, Alice Marceau, Olivier Nibourel, and Claude Preudhomme, Cancer Research Institute of Lille and Université Lille; and Céline Berthon, Claude Huriez Hospital, Lille; Stéphane de Botton, Institut Gustave Roussy, Villejuif; Denis Caillot, Dijon University Hospital, Dijon; Emilie Lemasle, Henri-Becquerel Center, Rouen; Jean-Pierre Marolleau, Amiens University Hospital, Amiens; Emmanuel Raffoux, Hervé Dombret, Jean-Michel Cayuela, Marie Magdeleine Coudé, Karine Celli-Lebras, and Nicolas Boissel, Hôpital Saint-Louis, AP-HP; Emmanuel Raffoux, Herve Dombret, and Nicolas Boissel, University 7 Paris Diderot; and Thorsten Braun, Hôpital Avicennes, AP-HP, Paris; Arnaud Pigneux, Haut-Leveque Hospital, Pessac; Norbert Vey, Paoli-Calmette Institute, Marseille; and Christine Terre, Hôpital de Versailles, Le Chesnay, France.
authors.forename: Hervé
authors.initials: H
authors.lastname: Dombret
authors.affiliation: Marie Balsat, Xavier Thomas, and Sandrine Hayette, Centre Hospitalier Lyon Sud, Pierre Benite; Aline Renneville, Alice Marceau, Olivier Nibourel, Céline Rodriguez, and Claude Preudhomme, CHRU of Lille; Aline Renneville, Alice Marceau, Olivier Nibourel, and Claude Preudhomme, Cancer Research Institute of Lille and Université Lille; and Céline Berthon, Claude Huriez Hospital, Lille; Stéphane de Botton, Institut Gustave Roussy, Villejuif; Denis Caillot, Dijon University Hospital, Dijon; Emilie Lemasle, Henri-Becquerel Center, Rouen; Jean-Pierre Marolleau, Amiens University Hospital, Amiens; Emmanuel Raffoux, Hervé Dombret, Jean-Michel Cayuela, Marie Magdeleine Coudé, Karine Celli-Lebras, and Nicolas Boissel, Hôpital Saint-Louis, AP-HP; Emmanuel Raffoux, Herve Dombret, and Nicolas Boissel, University 7 Paris Diderot; and Thorsten Braun, Hôpital Avicennes, AP-HP, Paris; Arnaud Pigneux, Haut-Leveque Hospital, Pessac; Norbert Vey, Paoli-Calmette Institute, Marseille; and Christine Terre, Hôpital de Versailles, Le Chesnay, France.
authors.forename: Claude
authors.initials: C
authors.lastname: Preudhomme
authors.affiliation: Marie Balsat, Xavier Thomas, and Sandrine Hayette, Centre Hospitalier Lyon Sud, Pierre Benite; Aline Renneville, Alice Marceau, Olivier Nibourel, Céline Rodriguez, and Claude Preudhomme, CHRU of Lille; Aline Renneville, Alice Marceau, Olivier Nibourel, and Claude Preudhomme, Cancer Research Institute of Lille and Université Lille; and Céline Berthon, Claude Huriez Hospital, Lille; Stéphane de Botton, Institut Gustave Roussy, Villejuif; Denis Caillot, Dijon University Hospital, Dijon; Emilie Lemasle, Henri-Becquerel Center, Rouen; Jean-Pierre Marolleau, Amiens University Hospital, Amiens; Emmanuel Raffoux, Hervé Dombret, Jean-Michel Cayuela, Marie Magdeleine Coudé, Karine Celli-Lebras, and Nicolas Boissel, Hôpital Saint-Louis, AP-HP; Emmanuel Raffoux, Herve Dombret, and Nicolas Boissel, University 7 Paris Diderot; and Thorsten Braun, Hôpital Avicennes, AP-HP, Paris; Arnaud Pigneux, Haut-Leveque Hospital, Pessac; Norbert Vey, Paoli-Calmette Institute, Marseille; and Christine Terre, Hôpital de Versailles, Le Chesnay, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Boissel
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009154:Mutation; D018365:Neoplasm, Residual / Q000235:genetics / Q000628:therapy*; D009687:Nuclear Proteins / Q000235:genetics*; D000090243:Nucleophosmin; D011379:Prognosis; D012074:Remission Induction; D033581:Stem Cell Transplantation; D016896:Treatment Outcome
chemical_list: C000716967:NPM1 protein, human; D009687:Nuclear Proteins; D000090243:Nucleophosmin