title: In Vivo Evaluation of the Anti-Inflammatory Effect ofPistacia lentiscusFruit Oil and Its Effects on Oxidative Stress.
abstract: In order to find new topical anti-inflammatory agents, we had recourse to a medicinal plant. This work was designed to determine the topical anti-inflammatory effect ofPistacia lentiscusfruit oil (PLFO), using carrageenan-induced paw edema rat model, and to evaluate its effects on oxidative stress. The topical anti-inflammatory activity of PLFO was compared to Inflocine® and estimated by measuring the diameter of paw edema, for 5 hours at a 1-hour interval. After that the rats were scarified and the inflamed paw tissue was removed for the exploration of some parameters of oxidative stress and histopathology. PLFO showed a significant anti-inflammatory activity in comparison with the Inflocine. The percentages of edema inhibition were 70% and % 51.5% (p< 0.01), respectively, after five hours. The treatment with PLFO and Inflocine led to significant increases (p≤ 0.05) in the activities of CAT, SOD, and GPX and significant decreases in the MDA level and AOPP activity in the paw tissue after Carr injection, in comparison with the Carr group. Therefore, our findings demonstrate that PLFO might accelerate the development of new drugs which could be used scientifically as a source for natural health products in the treatment of topical inflammation.
authors.affiliation: Research Unit of Anatomy-Histology and Embryology, Faculty of Medicine, Sfax, Tunisia.
authors.forename: Sameh
authors.identifier: 0000-0003-1612-1811
authors.initials: S
authors.lastname: Ben Khedir
authors.affiliation: Research Unit of Anatomy-Histology and Embryology, Faculty of Medicine, Sfax, Tunisia.
authors.forename: Masarra
authors.identifier: 0000-0002-5410-9728
authors.initials: M
authors.lastname: Mzid
authors.affiliation: Research Unit of Pharmacology, Faculty of Medicine, Sfax, Tunisia.
authors.forename: Sana
authors.initials: S
authors.lastname: Bardaa
authors.affiliation: Research Unit of Pharmacology, Faculty of Medicine, Sfax, Tunisia.
authors.forename: Dorsaf
authors.identifier: 0000-0002-0471-4014
authors.initials: D
authors.lastname: Moalla
authors.affiliation: Research Unit of Pharmacology, Faculty of Medicine, Sfax, Tunisia.
authors.forename: Zouheir
authors.initials: Z
authors.lastname: Sahnoun
authors.affiliation: Research Unit of Anatomy-Histology and Embryology, Faculty of Medicine, Sfax, Tunisia.
authors.forename: Tarek
authors.initials: T
authors.lastname: Rebai