title: The assessment and management of chemotherapy-related toxicities in patients with breast cancer, colorectal cancer, and Hodgkin's and non-Hodgkin's lymphomas: A scoping review.
abstract: OBJECTIVE
  The purpose of the eSMART (Electronic Symptom Management using the Advanced Symptom Management System (ASyMS) Remote Technology) study is to evaluate the use of mobile phone technology to manage chemotherapy-related toxicities (CRTs) in people with breast cancer (BC), colorectal cancer (CRC), Hodgkin's lymphoma (HL), and non-Hodgkin lymphoma (NHL)) across multiple European sites. One key objective was to review the published and grey literature on assessment and management of CRTs among patients receiving primary chemotherapy for BC, CRC, HL, and NHL to ensure that ASyMS remained evidence-based and reflected current and local practice.
  
  
  METHODS
  Three electronic databases were searched for English papers, with abstracts available from 01/01/2004-05/04/2014. For the grey literature, relevant clinical practice guidelines (CPGs)/evidence-based resources (EBRs) from the main international cancer organisations were reviewed as were symptom management (SM) protocols from the sites.
  
  
  RESULTS
  After full-text screening, 27 publications were included. The majority (n = 14) addressed fatigue and focused on BC patients. Relevant CPGs/EBRs were found for fatigue (n = 4), nausea/vomiting (n = 5), mucositis (n = 4), peripheral neuropathy (n = 3), diarrhoea (n = 2), constipation (n = 2), febrile neutropenia/infection (n = 7), palmar plantar erythrodysesthesia (PPE) (n = 1), and pain (n = 4). SM protocols were provided by >40% of the clinical sites.
  
  
  CONCLUSIONS
  A need exists for empirical research on SM for PPE, diarrhoea, and constipation. Research is needed on the efficacy of self-care strategies in patients with BC, CRC, HL, and NHL. In general, consistency exists across CPGs/EBRs and local guidelines on the assessment and management of common CRTs.
authors.affiliation: UCD School of Nursing, Midwifery and Health Systems, Health Sciences Centre, Belfield, Dublin 4, Ireland. Electronic address: patricia.fox@ucd.ie.
authors.forename: Patricia
authors.initials: P
authors.lastname: Fox
authors.affiliation: UCD School of Nursing, Midwifery and Health Systems, Health Sciences Centre, Belfield, Dublin 4, Ireland.
authors.forename: Andrew
authors.initials: A
authors.lastname: Darley
authors.affiliation: UCD School of Nursing, Midwifery and Health Systems, Health Sciences Centre, Belfield, Dublin 4, Ireland.
authors.forename: Eileen
authors.initials: E
authors.lastname: Furlong
authors.affiliation: Department of Physiological Nursing, University of California, San Francisco, CA 94143-0610, United States.
authors.forename: Christine
authors.initials: C
authors.lastname: Miaskowski
authors.affiliation: Papadiamantopoulou 123, 11527 Goudi, Athens, Greece.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Patiraki
authors.affiliation: Florence Nightingale SchNM, James Clerk Maxwell Building, Waterloo, United Kingdom.
authors.forename: Jo
authors.initials: J
authors.lastname: Armes
authors.affiliation: University of Surrey, School of Health Sciences, Faculty of Health and Medical Sciences, Guildford, Surrey, GU2 7XH, United Kingdom.
authors.forename: Emma
authors.initials: E
authors.lastname: Ream
authors.affiliation: University of Surrey School of Health Sciences, Faculty of Health & Medical Sciences, Standard Buildings, Office 2.4, 2nd Floor, 94 Hope Street Glasgow, G2 6PH, United Kingdom.
authors.forename: Constantina
authors.initials: C
authors.lastname: Papadopoulou
authors.affiliation: University of Surrey School of Health Sciences, Faculty of Health & Medical Sciences, Standard Buildings, Office 2.4, 2nd Floor, 94 Hope Street Glasgow, G2 6PH, United Kingdom.
authors.forename: Lisa
authors.initials: L
authors.lastname: McCann
authors.affiliation: University of Surrey, Faculty of Health and Medical Sciences, Duke of Kent Building, Guildford, Surrey, GU2 7XH, United Kingdom.
authors.forename: Nora
authors.initials: N
authors.lastname: Kearney
authors.affiliation: University of Surrey School of Health Sciences, Faculty of Health & Medical Sciences, Standard Buildings, Office 2.4, 2nd Floor, 94 Hope Street Glasgow, G2 6PH, United Kingdom.
authors.forename: Roma
authors.initials: R
authors.lastname: Maguire
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use* / Q000633:toxicity*; D001943:Breast Neoplasms / Q000188:drug therapy*; D040421:Cell Phone; D015179:Colorectal Neoplasms / Q000188:drug therapy*; D004358:Drug Therapy; D064420:Drug-Related Side Effects and Adverse Reactions / Q000209:etiology* / Q000628:therapy*; D005060:Europe; D005260:Female; D006689:Hodgkin Disease / Q000188:drug therapy*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D017216:Telemedicine
chemical_list: D000970:Antineoplastic Agents
keywords: Assessment; Chemotherapy; Clinical practice guideline; Management; Scoping review; Self-care; Symptom; Toxicity