title: Tongue somatosensory evoked potentials reflect midbrain involvement in patients with clinically isolated syndrome.
abstract: OBJECTIVE
  To test the hypothesis that tSSEP findings reflect clinical and MRI MS lesions, the aim of this study was to investigate tSSEP changes in patients with clinically isolated syndrome (CIS) in relation to clinical and brainstem MRI findings. The second aim was to investigate whether the interpretation of the tSSEP results in the form of the tSSEP score enables better evaluation of the afferent trigeminal pathway involvement than analyzing each tSSEP parameter separately.
  
  
  METHODS
  115 consecutive CIS patients were enrolled from August 1, 2014 until March 1, 2016. Facial sensory symptoms and brainstem MRI (1.5 T) lesions were analyzed. tSSEP testing was performed for each patient from the raw tSSEP data. The tSSEP score was calculated separately for the left and right side (according to the cut-off values for absent response and prolonged latency of the main component, P1 (0=normal response, 1=prolonged latency, 3=absent response) and the two values were summed.
  
  
  RESULTS
  There was no difference in the absolute values of the tSSEP variables regarding the presence of clinical symptoms. No association was found between tSSEP abnormalities and clinical symptoms (P=0.544). Brainstem lesions (midbrain and pons) were associated with the absent tSSEP responses (P=0.002 and P=0.005, respectively). tSSEP score was significantly higher in patients with brainstem lesions (P=0.01), especially midbrain (P=0.004) and pontine (P=0.008) lesions. Binary logistic regression showed that tSSEP score had a significant effect on the likelihood that patients have midbrain MR lesions, ?2(1)=6.804, P=0.009; and the model correctly classified 87% of cases.
  
  
  CONCLUSIONS
  The consistent finding of this study was the association between tSSEP and midbrain lesions on MRI, indicating that tSSEP evaluates proprioception of the face. This study establishes the value of tSSEP in assessing brainstem function in early multiple sclerosis.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Krbot Skorić
authors.forename: Ivan
authors.initials: I
authors.lastname: Adamec
authors.forename: Luka
authors.initials: L
authors.lastname: Crnošija
authors.forename: Tereza
authors.initials: T
authors.lastname: Gabelić
authors.forename: Barbara
authors.initials: B
authors.lastname: Barun
authors.forename: Ivana
authors.initials: I
authors.lastname: Zadro
authors.forename: Silva
authors.initials: S
authors.lastname: Butković Soldo
authors.affiliation: Mario Habek, Department of Neurology, University Hospital Center Zagreb, Kišpatićeva 12, HR-10000 Zagreb, Croatia, mhabek@mef.hr.
authors.forename: Mario
authors.initials: M
authors.lastname: Habek
mesh_terms: D000328:Adult; D001933:Brain Stem / Q000000981:diagnostic imaging / Q000503:physiopathology; D003711:Demyelinating Diseases / Q000503:physiopathology*; D005073:Evoked Potentials, Somatosensory / Q000502:physiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008636:Mesencephalon / Q000000981:diagnostic imaging / Q000503:physiopathology*; D009103:Multiple Sclerosis / Q000503:physiopathology