title: Retrospective evaluation of circulating thyroid hormones in critically ill dogs with systemic inflammatory response syndrome.
abstract: Critical illness can be associated with transient alterations in circulating thyroid hormone concentrations, indicating the presence of non-thyroidal illness (NTI). NTI is well described in humans, but there are few reports on its occurrence and prognostic significance in dogs. This retrospective study assessed the occurrence of NTI in a population of dogs with systemic inflammatory response syndrome (SIRS) and investigated its association with disease severity (APPLEfastscores). A total of 41 SIRS dogs were included and were divided by SIRS origin (non-septic SIRS, n = 10; septic SIRS, n = 41) and final outcome (survivors, n = 37; non-survivors, n = 4). Healthy, age-matched dogs (n = 15) were included as controls. Serum thyroid hormone levels including total T3, free T3, total T4, and reverse T3 were measured upon admission. Compared to controls, there were significant changes in serum thyroid hormone concentrations in SIRS dogs, suggesting the presence of NTI. Septic SIRS dogs had higher APPLEfastscores and lower serum thyroid hormones concentrations than those in non-septic SIRS and control dogs. In conclusion, NTI was frequent in dogs with SIRS and may be associated with the presence of sepsis or high illness severity.
authors.affiliation: Department of Veterinary Medical Sciences, Alma Mater Studiorum-University of Bologna, 40126 Bologna, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Giunti
authors.affiliation: Department of Veterinary Medical Sciences, Alma Mater Studiorum-University of Bologna, 40126 Bologna, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Troia
authors.affiliation: Department of Veterinary Medical Sciences, Alma Mater Studiorum-University of Bologna, 40126 Bologna, Italy.
authors.forename: Mara
authors.initials: M
authors.lastname: Battilani
authors.affiliation: Department of Veterinary Medical Sciences, Alma Mater Studiorum-University of Bologna, 40126 Bologna, Italy.
authors.forename: Luciana
authors.initials: L
authors.lastname: Giardino
authors.affiliation: Department of Veterinary Medical Sciences, Alma Mater Studiorum-University of Bologna, 40126 Bologna, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Dondi
authors.affiliation: Department of Veterinary Medical Sciences, Alma Mater Studiorum-University of Bologna, 40126 Bologna, Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: Andreani
authors.affiliation: Department of Veterinary Medical Sciences, Alma Mater Studiorum-University of Bologna, 40126 Bologna, Italy.
authors.forename: Federico
authors.initials: F
authors.lastname: Fracassi
mesh_terms: D000818:Animals; D016638:Critical Illness; D004283:Dog Diseases / Q000097:blood / Q000276:immunology* / Q000401:mortality; D004285:Dogs; D005260:Female; D007558:Italy / Q000453:epidemiology; D008297:Male; D012189:Retrospective Studies; D018746:Systemic Inflammatory Response Syndrome / Q000097:blood / Q000276:immunology / Q000401:mortality / Q000662:veterinary*; D013963:Thyroid Hormones / Q000097:blood*
chemical_list: D013963:Thyroid Hormones
keywords: canine; euthyroid sick syndrome; systemic inflammatory response syndrome; thyroid hormones