title: Thymoma-associated immunodeficiency: a diagnostic challenge for the clinician.
abstract: Good's syndrome or thymoma-associated immunodeficiency is a rare clinical entity that is often presumed to be common variable immunodeficiency, due to lack of awareness and recognition of this syndrome. This syndrome more often goes unrecognized if a thymoma is not detected. An appropriate immunological work-up that aids timely diagnosis and adequate therapy with antimicrobials and intravenous immunoglobulins are mandatory to prevent the long-term complications and mortality associated with this syndrome. We present the clinical and immunological profile of a young man with Good's syndrome that was initially presumed to be common variable immunodeficiency.
authors.affiliation: 1 Department of Respiratory Medicine, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India.
authors.forename: Narendra Kumar
authors.initials: NK
authors.lastname: Narahari
authors.affiliation: 1 Department of Respiratory Medicine, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India.
authors.forename: Paramjyothi Kruparao
authors.initials: PK
authors.lastname: Gongati
authors.affiliation: 1 Department of Respiratory Medicine, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India.
authors.forename: Bhaskar
authors.initials: B
authors.lastname: Kakarla
authors.affiliation: 2 Department of Emergency Medicine, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India.
authors.forename: Mohammed Ismail
authors.initials: MI
authors.lastname: Nizami
authors.affiliation: 1 Department of Respiratory Medicine, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India.
authors.forename: Rajendra Prasad
authors.initials: RP
authors.lastname: Boddula
authors.affiliation: 1 Department of Respiratory Medicine, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India.
authors.forename: Laxma Reddy
authors.initials: LR
authors.lastname: Sattavarapu
mesh_terms: D000361:Agammaglobulinemia / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy; D000890:Anti-Infective Agents / Q000627:therapeutic use; D017074:Common Variable Immunodeficiency / Q000175:diagnosis* / Q000276:immunology; D003951:Diagnostic Errors; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D013577:Syndrome; D013934:Thymectomy; D013945:Thymoma / Q000150:complications / Q000175:diagnosis* / Q000276:immunology / Q000601:surgery; D013953:Thymus Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000276:immunology / Q000601:surgery; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000890:Anti-Infective Agents; D016756:Immunoglobulins, Intravenous
keywords: Agammaglobulinemia; CVID; Good's syndrome; Immunodeficiency; Immunoglobulins; Thymoma; Thymus neoplasms; intravenous