title: Palladium-Catalyzed Remote Aryldifluoroalkylation of Alkenyl Aldehydes.
abstract: A palladium-catalyzed three-component reaction between fluoroalkyl bromides, arylboronic acids, and alkenyl aldehydes has been developed and provides facile access to 5-, 6-, or 7-difluoroalkylated ketones under very mild reaction conditions. The resultant products can be smoothly converted into CF2-containing tetrahydronaphthalenes by a novel silver-catalyzed intramolecular decarboxylative cyclization of 5-aryl-2,2-difluoropentanoic acids.
authors.affiliation: Department of Chemistry, Zhejiang Normal University, 688 Yingbin Road, Jinhua, 321004, P.R. China.
authors.forename: Xingliang
authors.initials: X
authors.lastname: Nie
authors.affiliation: Department of Chemistry, Zhejiang Normal University, 688 Yingbin Road, Jinhua, 321004, P.R. China.
authors.forename: Cungui
authors.initials: C
authors.lastname: Cheng
authors.affiliation: Department of Chemistry, Zhejiang Normal University, 688 Yingbin Road, Jinhua, 321004, P.R. China.
authors.forename: Gangguo
authors.initials: G
authors.lastname: Zhu
keywords: aldehydes; cyclization; difluoroalkylation; palladium; radicals