title: Annexin A6-A multifunctional scaffold in cell motility.
abstract: Annexin A6 (AnxA6) belongs to a highly conserved protein family characterized by their calcium (Ca2+)-dependent binding to phospholipids. Over the years, immunohistochemistry, subcellular fractionations, and live cell microscopy established that AnxA6 is predominantly found at the plasma membrane and endosomal compartments. In these locations, AnxA6 acts as a multifunctional scaffold protein, recruiting signaling proteins, modulating cholesterol and membrane transport and influencing actin dynamics. These activities enable AnxA6 to contribute to the formation of multifactorial protein complexes and membrane domains relevant in signal transduction, cholesterol homeostasis and endo-/exocytic membrane transport. Hence, AnxA6 has been implicated in many biological processes, including cell proliferation, survival, differentiation, inflammation, but also membrane repair and viral infection. More recently, we and others identified roles for AnxA6 in cancer cell migration and invasion. This review will discuss how the multiple scaffold functions may enable AnxA6 to modulate migratory cell behavior in health and disease.
authors.affiliation: a Faculty of Pharmacy , University of Sydney , Sydney , NSW , Australia.
authors.forename: Thomas
authors.initials: T
authors.lastname: Grewal
authors.affiliation: a Faculty of Pharmacy , University of Sydney , Sydney , NSW , Australia.
authors.forename: Monira
authors.initials: M
authors.lastname: Hoque
authors.affiliation: b The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Cancer Division, St Vincent's Clinical School, Faculty of Medicine , University of New South Wales , Sydney , NSW , Australia.
authors.forename: James R W
authors.initials: JRW
authors.lastname: Conway
authors.affiliation: c Departament de Biomedicina, Unitat de Biologia Cel·lular, Centre de Recerca Biomèdica CELLEX, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Facultat de Medicina , Universitat de Barcelona , Barcelona , Spain.
authors.forename: Meritxell
authors.initials: M
authors.lastname: Reverter
authors.affiliation: a Faculty of Pharmacy , University of Sydney , Sydney , NSW , Australia.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Wahba
authors.affiliation: a Faculty of Pharmacy , University of Sydney , Sydney , NSW , Australia.
authors.forename: Syed S
authors.initials: SS
authors.lastname: Beevi
authors.affiliation: b The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Cancer Division, St Vincent's Clinical School, Faculty of Medicine , University of New South Wales , Sydney , NSW , Australia.
authors.forename: Paul
authors.initials: P
authors.lastname: Timpson
authors.affiliation: c Departament de Biomedicina, Unitat de Biologia Cel·lular, Centre de Recerca Biomèdica CELLEX, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Facultat de Medicina , Universitat de Barcelona , Barcelona , Spain.
authors.forename: Carlos
authors.identifier: 0000-0003-0382-2993
authors.initials: C
authors.lastname: Enrich
authors.affiliation: c Departament de Biomedicina, Unitat de Biologia Cel·lular, Centre de Recerca Biomèdica CELLEX, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Facultat de Medicina , Universitat de Barcelona , Barcelona , Spain.
authors.forename: Carles
authors.initials: C
authors.lastname: Rentero
mesh_terms: D017317:Annexin A6 / Q000235:genetics* / Q000378:metabolism; D002448:Cell Adhesion / Q000235:genetics*; D002465:Cell Movement / Q000235:genetics; D049109:Cell Proliferation / Q000235:genetics; D006801:Humans; D009361:Neoplasm Invasiveness / Q000235:genetics* / Q000473:pathology; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology; D010743:Phospholipids / Q000235:genetics; D011485:Protein Binding; D015398:Signal Transduction
chemical_list: D017317:Annexin A6; D010743:Phospholipids
keywords: Annexin A6; EGFR/Ras; PKCα; SNAREs; actin; caveolin; cholesterol; integrins; invasion; migration; p120GAP; scaffold