title: 170Tm-EDTMP: A Prospective Alternative of 89SrCl2 for Theranostic Treatment of Metastatic Bone Pain.
abstract: We have earlier reported the potential of Tm-EDTMP as an alternative cost-effective radiopharmaceutical of SrCl2 for bone pain palliation application. Encouraging results obtained in the radiochemical studies and biological evaluations in animal model have prompted us to initiate the clinical study to evaluate the potential of Tm-EDTMP in human cancer patients. The serial scintigraphic images represent the whole-body scans of a patient (68 years old woman) with skeletal metastases of carcinoma of the breast origin recorded after administering 370 MBq (10 mCi) of Tm-EDTMP at different post-administration time points along with the pre-therapy images recorded with Tc-MDP in the same patient.
authors.affiliation: From the *Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Trombay, India; †Homi Bhabha National Institute, Anushaktinagar, Mumbai; ‡Department of Nuclear Medicine and PET, Kovai Medical Center and Hospital, Coimbatore, Tamil Nadu; and §Radiation Medicine Centre, Bhabha Atomic Research Centre, Trombay, Mumbai, India.
authors.forename: Tapas
authors.initials: T
authors.lastname: Das
authors.forename: Ajit
authors.initials: A
authors.lastname: Shinto
authors.forename: Koramadai Karuppuswamy
authors.initials: KK
authors.lastname: Kamaleshwaran
authors.forename: Sharmila
authors.initials: S
authors.lastname: Banerjee
mesh_terms: D000368:Aged; D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D000072716:Cancer Pain / Q000000981:diagnostic imaging*; D002277:Carcinoma / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006801:Humans; D009942:Organometallic Compounds; D063065:Organophosphonates; D019275:Radiopharmaceuticals; D013932:Thulium
chemical_list: C543419:170Tm-ethylenediamine-tetramethylenephosphonic acid; D009942:Organometallic Compounds; D063065:Organophosphonates; D019275:Radiopharmaceuticals; D013932:Thulium