title: Relationship between18F-Flutemetamol uptake and RBANS performance in non-demented community-dwelling older adults.
abstract: The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) has been used extensively for clinical care and in research for patients with mild cognitive impairment and Alzheimer's disease (AD); however, relatively few studies have evaluated the relationship between RBANS performance and AD imaging biomarkers. The purpose of the current study was to evaluate the association between a relatively new amyloid positron emission tomography imaging biomarker and performance on the RBANS.
  
  
  
  Twenty-seven nondemented community-dwelling adults over the age of 65 underwent18F-Flutemetamol amyloid- positron emission tomography imaging, along with cognitive testing using the RBANS and select behavioral measures. Partial correlation coefficients were used to identify relationships between the imaging and behavioral markers.
  
  
  
  After controlling for age and education, amyloid deposition and RBANS Indexes of Immediate Memory, Delayed Memory, and Total Scale score were significantly correlated (p's < .001, r's = -.73 to -.77, d's = 2.13-2.39), with greater amyloid burden being associated with lower RBANS scores. The Delayed Memory Index was particularly highly associated with18F-Flutemetamol binding (r2= .59, p < .001, d = 2.39). Neither18F-Flutemetamol binding nor RBANS performance was significantly correlated with levels of depression, subjective cognitive difficulties, or premorbid intellect.
  
  
  
  Because of the limited use of amyloid imaging in clinical settings due to high cost and lack of reimbursement, these findings suggest that in particular RBANS Delayed Memory Index may be a cost-efficient tool to identify early signs of AD pathology, and its use may enlighten clinical decision-making regarding potential progression to dementia due to AD.
authors.affiliation: a Department of Neurology, Center for Alzheimer's Care, Imaging, and Research , University of Utah , Salt Lake City , UT , USA.
authors.forename: Dustin B
authors.initials: DB
authors.lastname: Hammers
authors.affiliation: a Department of Neurology, Center for Alzheimer's Care, Imaging, and Research , University of Utah , Salt Lake City , UT , USA.
authors.forename: Taylor J
authors.initials: TJ
authors.lastname: Atkinson
authors.affiliation: a Department of Neurology, Center for Alzheimer's Care, Imaging, and Research , University of Utah , Salt Lake City , UT , USA.
authors.forename: Bonnie C A
authors.initials: BC
authors.lastname: Dalley
authors.affiliation: a Department of Neurology, Center for Alzheimer's Care, Imaging, and Research , University of Utah , Salt Lake City , UT , USA.
authors.forename: Kayla R
authors.initials: KR
authors.lastname: Suhrie
authors.affiliation: b Center for Quantitative Cancer Imaging, Huntsman Cancer Institute , University of Utah , Salt Lake City , UT , USA.
authors.forename: Britney E
authors.initials: BE
authors.lastname: Beardmore
authors.affiliation: b Center for Quantitative Cancer Imaging, Huntsman Cancer Institute , University of Utah , Salt Lake City , UT , USA.
authors.forename: Lance D
authors.initials: LD
authors.lastname: Burrell
authors.affiliation: b Center for Quantitative Cancer Imaging, Huntsman Cancer Institute , University of Utah , Salt Lake City , UT , USA.
authors.forename: Kevin P
authors.initials: KP
authors.lastname: Horn
authors.affiliation: b Center for Quantitative Cancer Imaging, Huntsman Cancer Institute , University of Utah , Salt Lake City , UT , USA.
authors.forename: Kelli M
authors.initials: KM
authors.lastname: Rasmussen
authors.affiliation: a Department of Neurology, Center for Alzheimer's Care, Imaging, and Research , University of Utah , Salt Lake City , UT , USA.
authors.forename: Norman L
authors.initials: NL
authors.lastname: Foster
authors.affiliation: a Department of Neurology, Center for Alzheimer's Care, Imaging, and Research , University of Utah , Salt Lake City , UT , USA.
authors.forename: Kevin
authors.initials: K
authors.lastname: Duff
authors.affiliation: b Center for Quantitative Cancer Imaging, Huntsman Cancer Institute , University of Utah , Salt Lake City , UT , USA.
authors.forename: John M
authors.initials: JM
authors.lastname: Hoffman
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000523:psychology; D016229:Amyloid beta-Peptides / Q000378:metabolism; D000814:Aniline Compounds / Q000493:pharmacokinetics*; D001519:Behavior; D052160:Benzothiazoles / Q000493:pharmacokinetics*; D003072:Cognition Disorders / Q000000981:diagnostic imaging / Q000523:psychology; D060825:Cognitive Dysfunction / Q000000981:diagnostic imaging* / Q000523:psychology*; D004522:Educational Status; D005260:Female; D006801:Humans; D007360:Intelligence; D008297:Male; D008568:Memory; D009483:Neuropsychological Tests; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*
chemical_list: D016229:Amyloid beta-Peptides; D000814:Aniline Compounds; D052160:Benzothiazoles; D019275:Radiopharmaceuticals; C581552:flutemetamol
keywords: Cognition; Mild Cognitive Impairment; RBANS; amyloid