title: A new indole alkaloid with anti-inflammatory activity from Nauclea officinalis.
abstract: A new indole alkaloid, 17-O-methyl-19-(Z)-naucline (1), together with seven known alkaloids (2-8), were isolated from the stems and leaves of Nauclea officinalis. The structure of 1 was elucidated by extensive spectroscopic methods and the known compounds were identified by comparisons their data with those reported in the literature. 17-O-methyl-19-(Z)-naucline (1) showed significant inhibitory activity on nitric oxide production induced by lipopolysaccharide in mouse macrophage RAW 264.7 cells in vitro with an IC50value of 3.6 μM.
authors.affiliation: a College of Pharmacy , Fujian University of Traditional Chinese Medicine , Fuzhou , P.R. China.|b Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education , Hainan Normal University , Haikou , P.R. China.
authors.forename: Qing-Long
authors.initials: QL
authors.lastname: Liu
authors.affiliation: a College of Pharmacy , Fujian University of Traditional Chinese Medicine , Fuzhou , P.R. China.|b Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education , Hainan Normal University , Haikou , P.R. China.
authors.forename: A-Hong
authors.initials: AH
authors.lastname: Chen
authors.affiliation: a College of Pharmacy , Fujian University of Traditional Chinese Medicine , Fuzhou , P.R. China.|b Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education , Hainan Normal University , Haikou , P.R. China.
authors.forename: Jin-Ying
authors.initials: JY
authors.lastname: Tang
authors.affiliation: a College of Pharmacy , Fujian University of Traditional Chinese Medicine , Fuzhou , P.R. China.|b Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education , Hainan Normal University , Haikou , P.R. China.
authors.forename: Yan-Lei
authors.initials: YL
authors.lastname: Ma
authors.affiliation: a College of Pharmacy , Fujian University of Traditional Chinese Medicine , Fuzhou , P.R. China.|b Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education , Hainan Normal University , Haikou , P.R. China.
authors.forename: Zhi-Hua
authors.initials: ZH
authors.lastname: Jiang
authors.affiliation: b Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education , Hainan Normal University , Haikou , P.R. China.
authors.forename: Yan-Ping
authors.initials: YP
authors.lastname: Liu
authors.affiliation: a College of Pharmacy , Fujian University of Traditional Chinese Medicine , Fuzhou , P.R. China.|b Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education , Hainan Normal University , Haikou , P.R. China.
authors.forename: Guang-Ying
authors.initials: GY
authors.lastname: Chen
authors.affiliation: a College of Pharmacy , Fujian University of Traditional Chinese Medicine , Fuzhou , P.R. China.|b Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education , Hainan Normal University , Haikou , P.R. China.
authors.forename: Yan-Hui
authors.initials: YH
authors.lastname: Fu
authors.affiliation: a College of Pharmacy , Fujian University of Traditional Chinese Medicine , Fuzhou , P.R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Xu
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D004353:Drug Evaluation, Preclinical / Q000379:methods; D026121:Indole Alkaloids / Q000737:chemistry* / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000378:metabolism; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D019666:Rubiaceae / Q000737:chemistry*
chemical_list: C000624336:17-O-methyl-19-(Z)-naucline; D000894:Anti-Inflammatory Agents, Non-Steroidal; D026121:Indole Alkaloids; D008070:Lipopolysaccharides; D009569:Nitric Oxide
keywords: Nauclea officinalis; anti-inflammatory activity; indole alkaloid; nitric oxide production