title: Gain of chromosome 1q portends worse prognosis in multiple myeloma despite novel agent-based induction regimens and autologous transplantation.
abstract: We aimed to identify whether the use of autologous hematopoietic cell transplantation (HCT) impacts outcomes for multiple myeloma patients with gains of chromosome 1q (+1q). We retrospectively identified 95 patients, 21% having +1q. For patients with +1q, the overall response rate to induction was 85%, with 40% having ≥ VGPR and 20% achieving a CR, similar to non +1q patients (p = .64). The median PFS from diagnosis with +1q was 2.1 years (95% CI: 1.2-not reached (NR)) vs 4.3 years (95% CI: 3.3 yrs-NR) without +1q (p = .003). Median OS from diagnosis was 4.4 years (95% CI: 2.9-NR) vs not reached, respectively (p = .005). On molecular analysis using the Foundation One Heme assay, the most common mutations seen in +1q patients included TP53 (38%) and KRAS (25%). Overall, gain of 1q portends worse PFS and OS which was not negated by auto HCT. Such patients will likely require additional therapy to improve their survival.
authors.affiliation: a Department of Medicine, Adult Bone Marrow Transplant Service , Memorial Sloan Kettering Cancer Center , New York , NY , USA.
authors.forename: Gunjan L
authors.initials: GL
authors.lastname: Shah
authors.affiliation: b Department of Medicine, Adult Bone Marrow Transplant Service , Memorial Sloan Kettering Cancer Center, NY Presbyterian Hospital - Weill Cornell Medical College , New York , NY , USA.
authors.forename: Heather
authors.initials: H
authors.lastname: Landau
authors.affiliation: c Department of Pathology , Memorial Sloan Kettering Cancer Center , New York , NY , USA.
authors.forename: Dory
authors.initials: D
authors.lastname: Londono
authors.affiliation: d Department of Biostatistics and Epidemiology , Memorial Sloan Kettering Cancer Center , New York , NY , USA.
authors.forename: Sean M
authors.initials: SM
authors.lastname: Devlin
authors.affiliation: a Department of Medicine, Adult Bone Marrow Transplant Service , Memorial Sloan Kettering Cancer Center , New York , NY , USA.
authors.forename: Satyajit
authors.initials: S
authors.lastname: Kosuri
authors.affiliation: e Department of Medicine , Myeloma Service, Memorial Sloan Kettering Cancer Center, NY Presbyterian Hospital - Weill Cornell Medical College , New York , NY , USA.
authors.forename: Alexander M
authors.initials: AM
authors.lastname: Lesokhin
authors.affiliation: e Department of Medicine , Myeloma Service, Memorial Sloan Kettering Cancer Center, NY Presbyterian Hospital - Weill Cornell Medical College , New York , NY , USA.
authors.forename: Nikoletta
authors.initials: N
authors.lastname: Lendvai
authors.affiliation: e Department of Medicine , Myeloma Service, Memorial Sloan Kettering Cancer Center, NY Presbyterian Hospital - Weill Cornell Medical College , New York , NY , USA.
authors.forename: Hani
authors.initials: H
authors.lastname: Hassoun
authors.affiliation: b Department of Medicine, Adult Bone Marrow Transplant Service , Memorial Sloan Kettering Cancer Center, NY Presbyterian Hospital - Weill Cornell Medical College , New York , NY , USA.
authors.forename: David J
authors.initials: DJ
authors.lastname: Chung
authors.affiliation: b Department of Medicine, Adult Bone Marrow Transplant Service , Memorial Sloan Kettering Cancer Center, NY Presbyterian Hospital - Weill Cornell Medical College , New York , NY , USA.
authors.forename: Guenther
authors.initials: G
authors.lastname: Koehne
authors.affiliation: c Department of Pathology , Memorial Sloan Kettering Cancer Center , New York , NY , USA.
authors.forename: Suresh C
authors.initials: SC
authors.lastname: Jhanwar
authors.affiliation: e Department of Medicine , Myeloma Service, Memorial Sloan Kettering Cancer Center, NY Presbyterian Hospital - Weill Cornell Medical College , New York , NY , USA.
authors.forename: Ola
authors.initials: O
authors.lastname: Landgren
authors.affiliation: f Department of Medicine, Leukemia Service , Memorial Sloan Kettering Cancer Center, NY Presbyterian Hospital - Weill Cornell Medical College , New York , NY , USA.
authors.forename: Ross
authors.initials: R
authors.lastname: Levine
authors.affiliation: b Department of Medicine, Adult Bone Marrow Transplant Service , Memorial Sloan Kettering Cancer Center, NY Presbyterian Hospital - Weill Cornell Medical College , New York , NY , USA.
authors.forename: Sergio A
authors.initials: SA
authors.lastname: Giralt
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D058674:Chromosome Duplication; D002878:Chromosomes, Human, Pair 1; D003131:Combined Modality Therapy; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007132:Immunoglobulin Isotypes / Q000097:blood; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality* / Q000628:therapy; D009367:Neoplasm Staging; D011379:Prognosis; D012074:Remission Induction; D016019:Survival Analysis; D014182:Transplantation, Autologous; D016896:Treatment Outcome
chemical_list: D007132:Immunoglobulin Isotypes
keywords: Neoplasia; clinical results; marrow and stem cell transplantation; myeloma; neoplasia – cytogenetics; neoplasia – molecular genetics