title: Sarcopenia and chemotherapy-mediated toxicity.
abstract: This narrative review focuses on the role of sarcopenia and chemotherapy-induced toxicity in cancer patients. Consistent evidence shows that sarcopenia in cancer patients leads to decreased overall survival by influencing treatment discontinuation and dose reduction. Therefore, sarcopenia should be considered a robust prognostic factor of negative outcome as well as a determinant of increased healthcare costs. RESUMO Esta revisão narrativa descreve o papel da sarcopenia e a toxicidade mediada pela quimioterapia em pacientes com câncer. Diversas evidências consistentes mostram que a sarcopenia em pacientes com câncer induz à menor sobrevida global, por influenciar na interrupção do tratamento e na redução da dose. Portanto, a sarcopenia pode ser considerada um importante fator de prognóstico de desfecho negativo, além de um determinante de maiores custos em saúde.
authors.affiliation: Centro Brasileiro de Radioterapia, Oncologia e Mastologia, Goiânia, GO, Brazil.
authors.forename: Maria Cecília Monteiro Dela
authors.initials: MC
authors.lastname: Vega
authors.affiliation: Department of Clinical Medicine, Sapienza University, Rome, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Laviano
authors.affiliation: Laboratório de Investigação em Nutrição Clínica e Esportiva, Faculdade de Nutrição, Universidade Federal de Goiás, Goiânia, GO, Brazil.
authors.forename: Gustavo Duarte
authors.initials: GD
authors.lastname: Pimentel
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D011379:Prognosis; D055948:Sarcopenia / Q000139:chemically induced*
chemical_list: D000970:Antineoplastic Agents