title: Seroprevalence of Cytomegalovirus Infection Among a Rural Population of Côte d'Ivoire.
abstract: Human cytomegalovirus (HCMV) is a betaherpesvirus that can be pathogenic to humans. In particular, immunocompromised patients can develop life-threatening symptoms. In the present study, HCMV seroprevalence was investigated in a rural population of Western Côte d'Ivoire. Plasma samples collected from 166 apparently healthy subjects living in 8 villages surrounding the Taï Forest National Park were tested for anti-HCMV immunoglobulin G and M antibody with two commercial enzyme-linked immunosorbent assays. Prevalence of anti-HCMV IgG and IgM antibody was 100% and 5.4%, respectively. Anti-HCMV IgM positive was 10.2% (5/49) of the children and adolescents and 3.4% (4/117) of the adults. This observed decrease of IgM seropositivity and the seroprevalence difference between males and females (3.8% vs. 6.1%) was not statistically significant. In plasma of one IgM-positive participant, a low CMV load was detected indicating low-level replication. A second IgM-positive participant showed signs of local CMV replication. The other seven IgM-positive plasma samples likely reacted nonspecifically or due to polyclonal stimulation. Taken together, the results indicate that HCMV infection is hyperendemic in Côte d'Ivoire.
authors.affiliation: 1 CHU de Bouaké/Centre de Recherche pour le Développement, Université Alassane Ouattara de Bouake , Bouake, Côte d'Ivoire.|2 UFR Biosciences, Université Félix Houphouët Boigny , Abidjan, Côte d'Ivoire.
authors.forename: Augustin Etile
authors.initials: AE
authors.lastname: Anoh
authors.affiliation: 2 UFR Biosciences, Université Félix Houphouët Boigny , Abidjan, Côte d'Ivoire.|3 LANADA/Laboratoire Central de Pathologie Animale , Bingerville, Côte d'Ivoire.
authors.forename: Arsène
authors.initials: A
authors.lastname: Mossoun
authors.affiliation: 1 CHU de Bouaké/Centre de Recherche pour le Développement, Université Alassane Ouattara de Bouake , Bouake, Côte d'Ivoire.
authors.forename: Chantal
authors.initials: C
authors.lastname: Akoua-Koffi
authors.affiliation: 3 LANADA/Laboratoire Central de Pathologie Animale , Bingerville, Côte d'Ivoire.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Couacy-Hymann
authors.affiliation: 4 Project P3 "Epidemiology of Highly Pathogenic Microorganisms," Robert Koch Institute, Berlin, Germany .|5 Division 12 "Measles, Mumps, Rubella and Viruses Affecting Immune-Compromised Patients," Robert Koch Institute, Berlin, Germany .
authors.forename: Maude
authors.initials: M
authors.lastname: Pauly
authors.affiliation: 4 Project P3 "Epidemiology of Highly Pathogenic Microorganisms," Robert Koch Institute, Berlin, Germany .
authors.forename: Siv-Aina
authors.initials: SA
authors.lastname: Leendertz
authors.affiliation: 2 UFR Biosciences, Université Félix Houphouët Boigny , Abidjan, Côte d'Ivoire.
authors.forename: Eliezer
authors.initials: E
authors.lastname: Kouakou N'goran
authors.affiliation: 4 Project P3 "Epidemiology of Highly Pathogenic Microorganisms," Robert Koch Institute, Berlin, Germany .
authors.forename: Grit
authors.initials: G
authors.lastname: Schubert
authors.affiliation: 4 Project P3 "Epidemiology of Highly Pathogenic Microorganisms," Robert Koch Institute, Berlin, Germany .
authors.forename: Sabrina
authors.initials: S
authors.lastname: Weiss
authors.affiliation: 6 Labor Berlin, Department of Virology, and Institut of Medical Virology, Charité University Medicine Berlin , Berlin, Germany .
authors.forename: Jörg
authors.initials: J
authors.lastname: Hofmann
authors.affiliation: 4 Project P3 "Epidemiology of Highly Pathogenic Microorganisms," Robert Koch Institute, Berlin, Germany .
authors.forename: Fabian H
authors.initials: FH
authors.lastname: Leendertz
authors.affiliation: 5 Division 12 "Measles, Mumps, Rubella and Viruses Affecting Immune-Compromised Patients," Robert Koch Institute, Berlin, Germany .
authors.forename: Bernhard
authors.initials: B
authors.lastname: Ehlers
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood; D002648:Child; D002675:Child, Preschool; D007560:Cote d'Ivoire / Q000453:epidemiology; D003587:Cytomegalovirus / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000453:epidemiology* / Q000821:virology; D019353:Endemic Diseases; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D008875:Middle Aged; D012424:Rural Population; D016036:Seroepidemiologic Studies; D012737:Sex Factors; D019562:Viral Load; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M
keywords: Côte d'Ivoire; IgG; IgM; cytomegalovirus; rural population; seroprevalence