title: Diagnostic Capability of Peripapillary Retinal Volume Measurements in Glaucoma.
abstract: OBJECTIVE
  To determine the diagnostic capability of spectral domain optical coherence tomography peripapillary retinal volume (RV) measurements.
  
  
  METHODS
  A total of 156 patients, 89 primary open-angle glaucoma and 67 normal subjects, were recruited. Spectral domain optical coherence tomography peripapillary RV was calculated for 4 quadrants using 3 annuli of varying scan circle diameters: outer circumpapillary annuli of circular grids 1, 2, and 3 (OCA1, OCA2, OCA3). Area under the receiver operating characteristic curves and pairwise comparisons of receiver operating characteristic (ROC) curves were performed to determine which quadrants were best for diagnosing primary open-angle glaucoma. The pairwise comparisons of the best ROC curves for RV and retinal nerve fiber layer (RNFL) were performed. The artifact rates were analyzed.
  
  
  RESULTS
  Pairwise comparisons showed that the smaller annuli OCA1 and OCA2 had better diagnostic performance than the largest annulus OCA3 (P<0.05 for all quadrants). OCA1 and OCA2 had similar diagnostic performance, except for the inferior quadrant which was better for OCA1 (P=0.0033). The pairwise comparisons of the best ROC curves for RV and RNFL were not statistically significant. RV measurements had lower rates of artifacts at 7.4% while RNFL measurements had higher rates at 42.9%.
  
  
  CONCLUSIONS
  Peripapillary RV measurements have excellent ability for diagnosing not only glaucoma patients but also a subset of early glaucoma patients. The inferior quadrant of peripapillary annulus OCA1 demonstrated the best diagnostic capability for both glaucoma and early glaucoma. The diagnostic ability of RV is comparable with that of RNFL parameters in glaucoma but with lower artifact rates.
authors.affiliation: *Department of Ophthalmology, Harvard Medical School, Glaucoma Service, Massachusetts Eye and Ear Infirmary, Boston, MA †Department of Ophthalmology, School of Medicine, Pamukkale University, Denizli, Turkey ‡Department of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung Taiwan §Department of Physics and Astronomy, Vrije Universiteit, Amsterdam, The Netherlands.
authors.forename: Huseyin
authors.initials: H
authors.lastname: Simavli
authors.forename: Linda Yi-Chieh
authors.initials: LY
authors.lastname: Poon
authors.forename: Christian J
authors.initials: CJ
authors.lastname: Que
authors.forename: Yingna
authors.initials: Y
authors.lastname: Liu
authors.forename: Mustafa
authors.initials: M
authors.lastname: Akduman
authors.forename: Edem
authors.initials: E
authors.lastname: Tsikata
authors.forename: Johannes F
authors.initials: JF
authors.lastname: de Boer
authors.forename: Teresa C
authors.initials: TC
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D019540:Area Under Curve; D005260:Female; D005901:Glaucoma / Q000175:diagnosis*; D005902:Glaucoma, Open-Angle / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology; D011237:Predictive Value of Tests; D012372:ROC Curve; D012160:Retina / Q000000981:diagnostic imaging*; D012165:Retinal Ganglion Cells / Q000473:pathology; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence / Q000379:methods*