title: Morphological, histological and immunohistochemical study of the area postrema in the dog.
abstract: Circumventricular organs are specialized brain structures that are located mainly at the midsagittal line, around the third and fourth ventricles, often protruding into the lumen. They are positioned at the interface between the neuroparenchyma and the ventricular system of the brain. These highly vascularized nervous tissue structures differ from the brain parenchyma, as they lack a blood-brain barrier. Circumventricular organs have specialized sensory and secretory functions. It is essential for any pathologist who evaluates brain sections to have a solid knowledge of microscopic neuroanatomy and to recognize these numerous specialized structures within the nervous system as normal and not mistake them for pathological changes. The purpose of this study was to provide, for the first time, a detailed and complete histological description of the healthy canine area postrema and to determine its resemblance to that of other mammalian species. Anatomical dissections with routine histological and immunohistochemical techniques were carried out on ten canine brains. The cellular composition of area postrema proved to be largely comparable to that of other mammal species.
authors.affiliation: Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, Universitat Autònoma de Barcelona, 08193, Bellaterra, Barcelona, Spain. mariaaoliveira@hotmail.com.|Fundació Hospital Clínic Veterinari, Universitat Autònoma de Barcelona, 08193, Bellaterra, Barcelona, Spain. mariaaoliveira@hotmail.com.|Pride Veterinary Centre, Derby, DE24 8HX, UK. mariaaoliveira@hotmail.com.
authors.forename: Maria
authors.identifier: http://orcid.org/0000-0003-4959-1262
authors.initials: M
authors.lastname: Oliveira
authors.affiliation: Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, Universitat Autònoma de Barcelona, 08193, Bellaterra, Barcelona, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Fernández
authors.affiliation: Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, Universitat Autònoma de Barcelona, 08193, Bellaterra, Barcelona, Spain.
authors.forename: Jordi
authors.initials: J
authors.lastname: Solé
authors.affiliation: Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, Universitat Autònoma de Barcelona, 08193, Bellaterra, Barcelona, Spain.
authors.forename: Martí
authors.initials: M
authors.lastname: Pumarola
mesh_terms: D000818:Animals; D020346:Aquaporins / Q000378:metabolism; D031608:Area Postrema / Q000033:anatomy & histology* / Q000098:blood supply / Q000166:cytology / Q000378:metabolism*; D004285:Dogs / Q000033:anatomy & histology*; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D007150:Immunohistochemistry; D007797:Laminin / Q000378:metabolism; D008297:Male; D000076104:Oligodendrocyte Transcription Factor 2 / Q000378:metabolism; D010751:Phosphopyruvate Hydratase / Q000378:metabolism
chemical_list: D020346:Aquaporins; D005904:Glial Fibrillary Acidic Protein; D007797:Laminin; D000076104:Oligodendrocyte Transcription Factor 2; D010751:Phosphopyruvate Hydratase
keywords: Area postrema; Circumventricular organs; Dog; Immunohistochemistry; Morphology