title: Small heat shock proteins in ageing and age-related diseases.
abstract: Small heat shock proteins (sHSPs) are gatekeepers of cellular homeostasis across species, preserving proteome integrity under stressful conditions. Nonetheless, recent evidence suggests that sHSPs are more than molecular chaperones with merely auxiliary role. In contrast, sHSPs have emerged as central lifespan determinants, and their malfunction has been associated with the manifestation of neurological disorders, cardiovascular disease and cancer malignancies. In this review, we focus on the role of sHSPs in ageing and age-associated diseases and highlight the most prominent paradigms, where impairment of sHSP function has been implicated in human pathology.
authors.affiliation: Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, 70013, Heraklion, Crete, Greece.|Department of Biology, University of Crete, 70013, Heraklion, Crete, Greece.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Charmpilas
authors.affiliation: Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, 70013, Heraklion, Crete, Greece.|Department of Biomedicine, Laboratory for Signal Transduction, Basel University Hospital and University of Basel, Basel, Switzerland.
authors.forename: Emmanouil
authors.initials: E
authors.lastname: Kyriakakis
authors.affiliation: Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, 70013, Heraklion, Crete, Greece. tavernarakis@imbb.forth.gr.|Department of Basic Sciences, Faculty of Medicine, University of Crete, 70013, Heraklion, Crete, Greece. tavernarakis@imbb.forth.gr.
authors.forename: Nektarios
authors.identifier: 0000-0002-5253-1466
authors.initials: N
authors.lastname: Tavernarakis
mesh_terms: D000375:Aging; D000818:Animals; D002318:Cardiovascular Diseases / Q000378:metabolism; D050888:Heat-Shock Proteins, Small / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism; D019636:Neurodegenerative Diseases / Q000378:metabolism; D011499:Protein Processing, Post-Translational
chemical_list: D050888:Heat-Shock Proteins, Small
keywords: Ageing; Cancer; Cardiovascular disease; Immunity; Neurodegeneration; Proteome; Small heat shock proteins