title: Synthesis and investigation of anticancer potential of radiolabeled naphthalene monoimide bearing imidazolium salt.
abstract: Imidazolium salts and derivatives have antitumor efficacy and toxic effects in different micro-organisms. In this study, an imidazolium bromide salt (NMI) was synthesized, and its antitumor potential was investigated by in vitro studies. Radiolabeling of synthesized NMI was carried out by iodogen method using131I radionuclide. The yield of radiolabeling was determined as 98.5 ± 0.1%. After that, cytotoxicity and intracellular uptake studies were evaluated in various cell lines. The cytotoxicity of NMI was determined as 35, 20, 10, and 1 μm for HEK-293, PC-3, CaCo-2, and MCF-7 cells, respectively. In addition, the intracellular uptake of131I-NMI was investigated in the cell lines, and the uptake was significantly found as 4 hr for MCF-7 and 6 hr for PC-3. In future studies, antitumor efficacy of131I-NMI on tumor-bearing animal model might be studied in light of these results.
authors.affiliation: Department of Nuclear Applications, Institute of Nuclear Science, Ege University, Izmir, Turkey.
authors.forename: Fatma
authors.identifier: 0000-0002-9394-6908
authors.initials: F
authors.lastname: Yurt Lambrecht
authors.affiliation: Advanced Technology Research & Application Center, Mersin University, Mersin, Turkey.|Department of Energy Systems Engineering, Tarsus Faculty of Technology, Mersin University, Mersin, Turkey.
authors.forename: Kasim
authors.initials: K
authors.lastname: Ocakoglu
authors.affiliation: Advanced Technology Research & Application Center, Mersin University, Mersin, Turkey.
authors.forename: Suleyman
authors.initials: S
authors.lastname: Gokhan Colak
authors.affiliation: Department of Nuclear Applications, Institute of Nuclear Science, Ege University, Izmir, Turkey.
authors.forename: Onur
authors.initials: O
authors.lastname: Alp Ersoz
authors.affiliation: Department of Nuclear Applications, Institute of Nuclear Science, Ege University, Izmir, Turkey.
authors.forename: Ozge
authors.initials: O
authors.lastname: Er
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D018938:Caco-2 Cells; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D057809:HEK293 Cells; D006801:Humans; D007093:Imidazoles / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D007094:Imides / Q000737:chemistry; D007457:Iodine Radioisotopes / Q000737:chemistry; D007553:Isotope Labeling; D061986:MCF-7 Cells; D009281:Naphthalenes / Q000737:chemistry; D012492:Salts / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D007093:Imidazoles; D007094:Imides; D007457:Iodine Radioisotopes; D009281:Naphthalenes; D012492:Salts; C031721:naphthalene
keywords: 131I; Radiolabeling; anticancer potential; imidazolium salts; nuclear medicine