title: A brief review on the application of nanoparticle enclosed herbal medicine for the treatment of infective endocarditis.
abstract: Herbal medicines have been routinely employed all over the world dated back from the ancient time and have been identified by patients and physicians for their excellent therapeutic value as they have lower adverse effects when compared with the modern medicines. Phytotherapeutics requires a scientific technique to deliver the active herbal extract in a controlled manner to avoid repeated administration and increase patient compliance. This can be reached by fabricating a novel drug delivery systems (NDDS) for herbal components. NDDSs does not only decrease the repeated dose to overcome ineffectiveness, but also help to increase potency by decreasing toxicity and elevating drug bioavailability. Nano-sized DDS of herbal drugs have a potential application for improving the activity and countering the problems related to herbal medicines. Hence, application of nanocarriers as an NDDS in the traditional herbal medicine system is important to treat more chronic diseases like infectious endocarditis.
authors.affiliation: Department of Cardiology, Lorestan University of Medical Sciences, Khoramabad, Iran.
authors.forename: Mehrdad
authors.initials: M
authors.lastname: Namdari
authors.affiliation: Department of Medical Biotechnology, School of Medicine, Lorestan University of Medical Sciences, Khoramabad, Iran; Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran; Razi Herbal Medicine Research Center, Lorestan University of Medical Science, Khorramabad, Iran. Electronic address: a-eatemadi@razi.tums.ac.ir.
authors.forename: Ali
authors.initials: A
authors.lastname: Eatemadi
authors.affiliation: Babol University of Medical Sciences, Babol, Iran; Student of Research Committee, Lorestan University of Medical Sciences, Khoramabad, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Soleimaninejad
authors.affiliation: Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Aiyelabegan T
authors.initials: AT
authors.lastname: Hammed
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000378:metabolism; D016503:Drug Delivery Systems / Q000379:methods*; D004696:Endocarditis / Q000188:drug therapy* / Q000378:metabolism; D029001:Herbal Medicine / Q000379:methods*; D006801:Humans; D053758:Nanoparticles / Q000008:administration & dosage* / Q000378:metabolism; D016896:Treatment Outcome
chemical_list: D000890:Anti-Infective Agents
keywords: Herbal drugs; Infective endocarditis; Nanotechnology; Novel drug delivery systems