title: Enantiomers Recognition of Propranolol Based on Organic-Inorganic Hybrid Open-Tubular MIPs-CEC Column Using 3-(Trimethoxysilyl)Propyl Methacrylate as a Cross-Linking Monomer.
abstract: In this study, 3-(trimethoxysilyl)propyl methacrylate (γ-MPS), a bifunctional group compound, was used as a single cross-linking agent to prepare molecular imprinted inorganic-organic hybrid polymers by in situ polymerization for open-tubular capillary electro chromatography (CEC) column. The optimal preparation conditions were: the ratio between template molecule and functional monomer was 1:4; the volume proportion of porogen toluene and methanol was 1:1 and the volume of cross-linking agent γ-MPS was 69 μL. The optimal separation conditions were separation voltage of 15 kV; detection wavelength at 215 nm and background electrolyte composed of 70% acetonitrile/20 mmol/L boric acid salt (pH 6.9). Under the optimized conditions, the propranolol enantiomers can be separated well by CEC. The method is simple and fast, it can be a potentially useful approach for propranolol enantiomers separation.
authors.affiliation: School of Pharmacy, Institute of Pharmaceutical Analysis, Lanzhou University, Lanzhou 730000, Gansu Province, PR China.|School of Pharmacy, Xi'an Jiaotong University, Xi'an 710061, PR China.
authors.forename: Guo-Ning
authors.initials: GN
authors.lastname: Chen
authors.affiliation: School of Pharmacy, Institute of Pharmaceutical Analysis,Lanzhou University, Lanzhou 730000, Gansu Province, PR China.
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.affiliation: School of Pharmacy, Institute of Pharmaceutical Analysis,Lanzhou University, Lanzhou 730000, Gansu Province, PR China.
authors.forename: Tian
authors.initials: T
authors.lastname: Luo
authors.affiliation: School of Pharmacy, Institute of Pharmaceutical Analysis,Lanzhou University, Lanzhou 730000, Gansu Province, PR China.
authors.forename: Yu-Ming
authors.initials: YM
authors.lastname: Dong