title: Neuroendocrine Underpinnings of Increased Risk for Posttraumatic Stress Disorder in Women.
abstract: Women are particularly vulnerable to the effects of psychological trauma and the development of trauma-, stressor-, and anxiety-related mental illnesses such as posttraumatic stress disorder (PTSD). In the current chapter, we examine the female hormonal systems that interact with psychobiological stress response systems to elicit maladaptive behavior and mental disease states in traumatized female populations. In addition, we provide a contemporary translational example of a stress vulnerability genomic profile (coding for pituitary adenylate cyclase-activating polypeptide) that may underlie the specific susceptibilities observed in women. Translational scientific investigations such as those described herein may lead to the identification of risk and resilience factors for PTSD as well as enhanced clinical interventions for treating excessive fear and anxiety.
authors.affiliation: Trauma Recovery Program, Mental Health Service Line, Atlanta Veterans Affairs Medical Center, Decatur, GA, United States; Emory University School of Medicine, Atlanta, GA, United States.
authors.forename: M A
authors.initials: MA
authors.lastname: Briscione
authors.affiliation: Emory University School of Medicine, Atlanta, GA, United States; Yerkes National Primate Research Center, Atlanta, GA, United States.
authors.forename: V
authors.initials: V
authors.lastname: Michopoulos
authors.affiliation: Emory University School of Medicine, Atlanta, GA, United States.
authors.forename: T
authors.initials: T
authors.lastname: Jovanovic
authors.affiliation: Trauma Recovery Program, Mental Health Service Line, Atlanta Veterans Affairs Medical Center, Decatur, GA, United States; Emory University School of Medicine, Atlanta, GA, United States. Electronic address: seth.norrholm@emoryhealthcare.org.
authors.forename: S D
authors.initials: SD
authors.lastname: Norrholm
mesh_terms: D000328:Adult; D000818:Animals; D004967:Estrogens / Q000378:metabolism*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism / Q000502:physiology / Q000503:physiopathology; D008297:Male; D009490:Neurosecretory Systems / Q000502:physiology / Q000503:physiopathology*; D010053:Ovary / Q000378:metabolism*; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide / Q000097:blood / Q000378:metabolism; D010913:Pituitary-Adrenal System / Q000378:metabolism / Q000502:physiology / Q000503:physiopathology; D020641:Polymorphism, Single Nucleotide; D051237:Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I / Q000819:agonists / Q000235:genetics / Q000378:metabolism; D012306:Risk; D012737:Sex Factors; D013313:Stress Disorders, Post-Traumatic / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology*; D013737:Testis / Q000378:metabolism; D013739:Testosterone / Q000378:metabolism
chemical_list: C495401:ADCYAP1 protein, human; C495503:ADCYAP1R1 protein, human; D004967:Estrogens; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D051237:Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I; D013739:Testosterone
keywords: Anxiety; Estrogen; Fear; Hormones; Trauma; Women