title: Enantioselective Synthesis of Chiral Oxygen-Containing Heterocycles Using Copper-Catalyzed Aryl C-O Coupling Reactions via Asymmetric Desymmetrization.
abstract: An enantioselective desymmetric aryl C-O coupling reaction was demonstrated under the catalysis of CuI and a chiral cyclic diamine ligand. A series of chiral oxygen-containing heterocyclic units such as 2,3-dihydrobenzofurans, chromans, and 1,4-benzodioxanes with tertiary or quaternary stereocarbon centers were synthesized with this method. DFT calculations were also carried out for a better understanding of the model for enantiocontrol.
authors.affiliation: College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology , Shijiazhuang, 050018, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology , Shijiazhuang, 050018, China.|College of Pharmacy, Jinan University , No. 601 Huangpu Avenue West, Guangzhou, 510632, China.
authors.forename: Qiuyan
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Laboratory of Computational Chemistry and Drug Design, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School , Shenzhen, 518055, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Wang
authors.affiliation: College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology , Shijiazhuang, 050018, China.|College of Pharmacy, Jinan University , No. 601 Huangpu Avenue West, Guangzhou, 510632, China.
authors.forename: Huan
authors.initials: H
authors.lastname: He
authors.affiliation: College of Pharmacy, Linyi University , Shuangling Road, Linyi, 276000, China.
authors.forename: Wenqiang
authors.initials: W
authors.lastname: Yang
authors.affiliation: Laboratory of Computational Chemistry and Drug Design, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School , Shenzhen, 518055, China.
authors.forename: Xinhao
authors.identifier: 0000-0002-8210-2531
authors.initials: X
authors.lastname: Zhang
authors.affiliation: College of Pharmacy, Jinan University , No. 601 Huangpu Avenue West, Guangzhou, 510632, China.
authors.forename: Qian
authors.identifier: 0000-0002-5700-3275
authors.initials: Q
authors.lastname: Cai