title: Pain Relief in Nonhuman Primate Models of Arthritis.
abstract: Animal models of rheumatoid arthritis are important in the elucidation of etiopathogenic mechanisms of the disease and for the development of promising new therapies. Species specificity of new biological compounds and their mode of action preclude safety and efficacy testing in rodent models of disease. Nonhuman primates (NHP) can fill this niche and provide the only relevant model. Over the last two decades models of collagen-induced arthritis (CIA) were developed in the rhesus monkey and the common marmoset. However, NHP are higher-order animals and complex sentient beings. So especially in models where pain is an intricate part of the disease, analgesia needs to be addressed because of ethical considerations. In our model, a morphine-based pain relief was used that does not interfere with the normal development of disease allowing us to evaluate important mechanistic aspects of the arthritis.
authors.affiliation: Department of Immunobiology, BPRC, Biomedical Primate Research Centre, P.O. Box 3306, 2280 GH, Rijswijk, The Netherlands. vierboom@bprc.nl.
authors.forename: Michel P M
authors.initials: MPM
authors.lastname: Vierboom
authors.affiliation: Department of Immunobiology, BPRC, Biomedical Primate Research Centre, P.O. Box 3306, 2280 GH, Rijswijk, The Netherlands.
authors.forename: Elia
authors.initials: E
authors.lastname: Breedveld
authors.affiliation: Animal Science Department, BPRC, Biomedical Primate Research Centre, Rijswijk, The Netherlands.
authors.forename: Merei
authors.initials: M
authors.lastname: Keehnen
authors.affiliation: Animal Science Department, BPRC, Biomedical Primate Research Centre, Rijswijk, The Netherlands.
authors.forename: Rianne
authors.initials: R
authors.lastname: Klomp
authors.affiliation: Animal Science Department, BPRC, Biomedical Primate Research Centre, Rijswijk, The Netherlands.
authors.forename: Jaco
authors.initials: J
authors.lastname: Bakker
mesh_terms: D000701:Analgesics, Opioid; D000818:Animals; D001169:Arthritis, Experimental / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D002047:Buprenorphine; D002144:Callithrix; D004334:Drug Administration Schedule; D008253:Macaca mulatta; D010146:Pain / Q000150:complications / Q000503:physiopathology / Q000517:prevention & control*; D059408:Pain Management / Q000379:methods*; D010147:Pain Measurement / Q000379:methods; D012720:Severity of Illness Index
chemical_list: D000701:Analgesics, Opioid; D002047:Buprenorphine
keywords: Autoimmunity; Inflammatory arthritis; NSAID; Nonhuman primates; Pain relief; Refinement