title: Comprehensive Genomic Analysis of Metastatic Mucinous Urethral Adenocarcinoma Guides Precision Oncology Treatment: Targetable EGFR Amplification Leading to Successful Treatment With Erlotinib.
authors.affiliation: Division of Hematology/Oncology, Mayo Clinic, Phoenix, AZ; Mayo Clinic Cancer Center, Phoenix, AZ; Center for Individualized Medicine, Mayo Clinic, Rochester, MN. Electronic address: bryce.alan@mayo.edu.
authors.forename: Alan H
authors.initials: AH
authors.lastname: Bryce
authors.affiliation: Division of Hematology/Oncology, Mayo Clinic, Phoenix, AZ; Mayo Clinic Cancer Center, Phoenix, AZ; Center for Individualized Medicine, Mayo Clinic, Rochester, MN.
authors.forename: Mitesh J
authors.initials: MJ
authors.lastname: Borad
authors.affiliation: Center for Individualized Medicine, Mayo Clinic, Rochester, MN.
authors.forename: Jan B
authors.initials: JB
authors.lastname: Egan
authors.affiliation: Mayo Clinic Cancer Center, Phoenix, AZ.
authors.forename: Rachel M
authors.initials: RM
authors.lastname: Condjella
authors.affiliation: Translational Genomics Research Institute, Phoenix, AZ.
authors.forename: Winnie S
authors.initials: WS
authors.lastname: Liang
authors.affiliation: Division of Hematology/Oncology, Mayo Clinic, Phoenix, AZ; Mayo Clinic Cancer Center, Phoenix, AZ; Center for Individualized Medicine, Mayo Clinic, Rochester, MN.
authors.forename: Rafael
authors.initials: R
authors.lastname: Fonseca
authors.affiliation: Department of Laboratory Medicine and Pathology, Mayo Clinic, Scottsdale, AZ.
authors.forename: Ann E
authors.initials: AE
authors.lastname: McCullough
authors.affiliation: Division of Hematology/Oncology, Mayo Clinic, Phoenix, AZ.
authors.forename: Katherine S
authors.initials: KS
authors.lastname: Hunt
authors.affiliation: Mayo Clinic Cancer Center, Phoenix, AZ.
authors.forename: Nicole R
authors.initials: NR
authors.lastname: Ritacca
authors.affiliation: Mayo Clinic Cancer Center, Phoenix, AZ; Translational Genomics Research Institute, Phoenix, AZ.
authors.forename: Michael T
authors.initials: MT
authors.lastname: Barrett
authors.affiliation: Department of Radiology, Mayo Clinic, Scottsdale, AZ.
authors.forename: Maitray D
authors.initials: MD
authors.lastname: Patel
authors.affiliation: Department of Radiology, Mayo Clinic, Scottsdale, AZ.
authors.forename: Scott W
authors.initials: SW
authors.lastname: Young
authors.affiliation: Department of Radiology, Mayo Clinic, Scottsdale, AZ.
authors.forename: Alvin C
authors.initials: AC
authors.lastname: Silva
authors.affiliation: Division of Hematology/Oncology, Mayo Clinic, Phoenix, AZ; Mayo Clinic Cancer Center, Phoenix, AZ; Center for Individualized Medicine, Mayo Clinic, Rochester, MN.
authors.forename: Thai H
authors.initials: TH
authors.lastname: Ho
authors.affiliation: Division of Hematology/Oncology, Mayo Clinic, Phoenix, AZ; Mayo Clinic Cancer Center, Phoenix, AZ; Center for Individualized Medicine, Mayo Clinic, Rochester, MN.
authors.forename: Thorvardur R
authors.initials: TR
authors.lastname: Halfdanarson
authors.affiliation: Department of Laboratory Medicine and Pathology, Mayo Clinic, Scottsdale, AZ.
authors.forename: Melissa L
authors.initials: ML
authors.lastname: Stanton
authors.affiliation: Department of Anatomic and Clinical Pathology, Mayo Clinic, Rochester, MN.
authors.forename: John
authors.initials: J
authors.lastname: Cheville
authors.affiliation: Department of Urology, Mayo Clinic, Phoenix, AZ.
authors.forename: Scott
authors.initials: S
authors.lastname: Swanson
authors.affiliation: Department of Urology, Mayo Clinic, Phoenix, AZ.
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Schneider
authors.affiliation: Center for Individualized Medicine, Mayo Clinic, Rochester, MN; Mayo Clinic Cancer Center, Rochester, MN.
authors.forename: Robert R
authors.initials: RR
authors.lastname: McWilliams
authors.affiliation: Translational Genomics Research Institute, Phoenix, AZ.
authors.forename: Angela
authors.initials: A
authors.lastname: Baker
authors.affiliation: Translational Genomics Research Institute, Phoenix, AZ.
authors.forename: Jessica
authors.initials: J
authors.lastname: Aldrich
authors.affiliation: Translational Genomics Research Institute, Phoenix, AZ.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Kurdoglu
authors.affiliation: Translational Genomics Research Institute, Phoenix, AZ.
authors.forename: Tyler
authors.initials: T
authors.lastname: Izatt
authors.affiliation: Translational Genomics Research Institute, Phoenix, AZ.
authors.forename: Alexis
authors.initials: A
authors.lastname: Christoforides
authors.affiliation: Translational Genomics Research Institute, Phoenix, AZ.
authors.forename: Irene
authors.initials: I
authors.lastname: Cherni
authors.affiliation: Translational Genomics Research Institute, Phoenix, AZ.
authors.forename: Sara
authors.initials: S
authors.lastname: Nasser
authors.affiliation: Translational Genomics Research Institute, Phoenix, AZ.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Reiman
authors.affiliation: Translational Genomics Research Institute, Phoenix, AZ.
authors.forename: Lori
authors.initials: L
authors.lastname: Cuyugan
authors.affiliation: Translational Genomics Research Institute, Phoenix, AZ.
authors.forename: Jacquelyn
authors.initials: J
authors.lastname: McDonald
authors.affiliation: Translational Genomics Research Institute, Phoenix, AZ.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Adkins
authors.affiliation: Translational Genomics Research Institute, Phoenix, AZ.
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Mastrian
authors.affiliation: Translational Genomics Research Institute, Phoenix, AZ.
authors.forename: Daniel D
authors.initials: DD
authors.lastname: Von Hoff
authors.affiliation: Translational Genomics Research Institute, Phoenix, AZ.
authors.forename: David W
authors.initials: DW
authors.lastname: Craig
authors.affiliation: Division of Hematology/Oncology, Mayo Clinic, Phoenix, AZ; Mayo Clinic Cancer Center, Phoenix, AZ; Center for Individualized Medicine, Mayo Clinic, Rochester, MN.
authors.forename: A Keith
authors.initials: AK
authors.lastname: Stewart
authors.affiliation: Translational Genomics Research Institute, Phoenix, AZ.
authors.forename: John D
authors.initials: JD
authors.lastname: Carpten
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000188:drug therapy* / Q000235:genetics; D000368:Aged; D066246:ErbB Receptors / Q000235:genetics*; D000069347:Erlotinib Hydrochloride / Q000008:administration & dosage* / Q000627:therapeutic use; D005784:Gene Amplification; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis; D057285:Precision Medicine; D017422:Sequence Analysis, DNA / Q000379:methods*; D015854:Up-Regulation; D014523:Urethral Neoplasms / Q000188:drug therapy* / Q000235:genetics
chemical_list: D000069347:Erlotinib Hydrochloride; C512478:EGFR protein, human; D066246:ErbB Receptors
keywords: EGFR; Exome; Genome; Transcriptome; Urethral adenocarcinoma