title: Improved mucoadhesive properties of self-nanoemulsifying drug delivery systems (SNEDDS) by introducing acyl chitosan.
abstract: This study was aimed to improve the mucoadhesive properties of SNEDDS by the incorporation of acyl chitosan including octanoyl chitosan (OC), lauroyl chitosan (LC) and palmitoyl chitosan (PC). SNEDDS and acyl chitosan SNEDDS were characterized regarding droplet size and zeta potential. Their mucoadhesivity on porcine intestinal mucosa was evaluated by falling liquid film technique using Sudan Red G as marker. Degree of substitution of chitosan was determined to be 52.8%, 64.8 and 48.5% for OC, LC and PC, respectively. SNEDDS and acyl chitosan SNEDDS displayed a droplet size less than 50nm and 80-300nm as well as a zeta potential of -0.2 to -1.6 and 0.05 to 0.99mV, respectively. Introducing 2% acyl chitosan into SNEDDS increased the residence time of SNEDDS on intestinal mucosa 2-fold. It is concluded that due to the incorporation of acyl chitosan into SNEDDS, their mucoadhesive properties can be increased.
authors.affiliation: Department of Pharmaceutical Technology, Institute of Pharmacy, Leopold-Franzens- University of Innsbruck, Innrain 80/82, A-6020 Innsbruck, Austria; Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Ahmad Dahlan, Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia.
authors.forename: Nuri Ari
authors.initials: NA
authors.lastname: Efiana
authors.affiliation: Department of Pharmaceutical Technology, Institute of Pharmacy, Leopold-Franzens- University of Innsbruck, Innrain 80/82, A-6020 Innsbruck, Austria.
authors.forename: Arshad
authors.initials: A
authors.lastname: Mahmood
authors.affiliation: Department of Pharmaceutical Technology, Institute of Pharmacy, Leopold-Franzens- University of Innsbruck, Innrain 80/82, A-6020 Innsbruck, Austria; Department of Pharmaceutical Technology, Faculty of Pharmacy, Can Tho University of Medicine and Pharmacy, Can Tho, Vietnam.
authors.forename: Hung Thanh
authors.initials: HT
authors.lastname: Lam
authors.affiliation: Department of Pharmaceutical Technology, Institute of Pharmacy, Leopold-Franzens- University of Innsbruck, Innrain 80/82, A-6020 Innsbruck, Austria.
authors.forename: Ožbej
authors.initials: O
authors.lastname: Zupančič
authors.affiliation: Department of Pharmaceutical Technology, Institute of Pharmacy, Leopold-Franzens- University of Innsbruck, Innrain 80/82, A-6020 Innsbruck, Austria.
authors.forename: Gintare
authors.initials: G
authors.lastname: Leonaviciute
authors.affiliation: Department of Pharmaceutical Technology, Institute of Pharmacy, Leopold-Franzens- University of Innsbruck, Innrain 80/82, A-6020 Innsbruck, Austria. Electronic address: andreas.bernkop@uibk.ac.at.
authors.forename: Andreas
authors.initials: A
authors.lastname: Bernkop-Schnürch
mesh_terms: D000269:Adhesives / Q000008:administration & dosage* / Q000737:chemistry*; D000818:Animals; D048271:Chitosan / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods; D004655:Emulsions / Q000008:administration & dosage* / Q000737:chemistry*; D007413:Intestinal Mucosa / Q000378:metabolism*; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D010316:Particle Size; D013552:Swine
chemical_list: D000269:Adhesives; D004337:Drug Carriers; D004655:Emulsions; D048271:Chitosan
keywords: Acyl chitosan; Fatty acid chloride; Mucoadhesion; SNEDDS