title: Abdominal paracentesis drainage improves tolerance of enteral nutrition in acute pancreatitis: a randomized controlled trial.
abstract: OBJECTIVE
  The objective of this study is to determine whether abdominal paracentesis drainage (APD) could improve the administration of enteral nutrition (EN) in acute pancreatitis.
  
  
  METHODS
  Between January 2015 and April 2016, a total of 161 acute pancreatitis patients were enrolled and randomly assigned to either the APD group or the non-APD group. Several indexes associated with the administration of EN, including the gastroparesis cardinal symptom index (GCSI), the incidence of gastrointestinal adverse events, and the clinical outcomes, were recorded.
  
  
  RESULTS
  The mean GCSI scores were 13.6 ± 2.1 before randomization and 7.1 ± 2.3 after a week in the APD group. These scores were 13.9 ± 2.4 and 9.7 ± 1.9 in the non-APD group. The incidences of gastrointestinal adverse events in the two groups were similar (p > .05), except for diarrhea. However, the patients in the APD group spent less time achieving the nutrition target (25 per kilogram of body weight per day) and fully tolerated the oral diet (p < .05). Additionally, the clinical outcomes of the APD group were better compared with those of the non-APD group.
  
  
  CONCLUSIONS
  APD can improve the administration of EN in acute pancreatitis. Given the positive effect of EN on clinical outcomes, this phenomenon possibly explains why APD could improve the clinical outcomes of acute pancreatitis patients in some aspects.
authors.affiliation: a Department of General Surgery , Chengdu Military General Hospital , Chengdu , Sichuan Province , China.
authors.forename: Liang
authors.initials: L
authors.lastname: Hongyin
authors.affiliation: b Department of Postgraduate , Third Military Medical University , Chongqing , China.
authors.forename: Huang
authors.initials: H
authors.lastname: Zhu
authors.affiliation: a Department of General Surgery , Chengdu Military General Hospital , Chengdu , Sichuan Province , China.
authors.forename: Wang
authors.initials: W
authors.lastname: Tao
authors.affiliation: c Department of Clinical Nutrition , Chengdu Military General Hospital , Chengdu , Sichuan Province , China.
authors.forename: Lin
authors.initials: L
authors.lastname: Ning
authors.affiliation: a Department of General Surgery , Chengdu Military General Hospital , Chengdu , Sichuan Province , China.
authors.forename: Liu
authors.initials: L
authors.lastname: Weihui
authors.affiliation: a Department of General Surgery , Chengdu Military General Hospital , Chengdu , Sichuan Province , China.
authors.forename: Cui
authors.initials: C
authors.lastname: Jianfeng
authors.affiliation: a Department of General Surgery , Chengdu Military General Hospital , Chengdu , Sichuan Province , China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Hongtao
authors.affiliation: a Department of General Surgery , Chengdu Military General Hospital , Chengdu , Sichuan Province , China.
authors.forename: Tang
authors.initials: T
authors.lastname: Lijun
mesh_terms: D000005:Abdomen / Q000601:surgery*; D000208:Acute Disease; D000328:Adult; D000368:Aged; D002681:China; D004322:Drainage; D004750:Enteral Nutrition / Q000009:adverse effects; D005260:Female; D018589:Gastroparesis / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000628:therapy*; D019152:Paracentesis / Q000379:methods*; D012720:Severity of Illness Index; D016896:Treatment Outcome
keywords: Abdominal paracentesis drainage; acute pancreatitis; enteral nutrition; randomized controlled trial