title: Extra-Articular Symptoms in Constellation with Selected Serum Cytokines and Disease Activity in Spondyloarthritis.
abstract: Objectives.In this study, we assessed the extra-articular symptoms in constellation with selected serum cytokines and disease activity in spondyloarthritis (SpA).Patients and Methods.We studied 287 SpA patients: 131 had AS, 110 had PsA, and 46 had SAPHO. We assessed extra-articular symptoms in all cases. In 191 SpA patients, we measured serum interleukin-6 (IL-6), interleukin-18 (IL-18), interleukin-23 (IL-23), endothelin-1 (ET-1), vascular endothelial growth factor (VEGF), and epidermal growth factor (EGF).Results.Patients with acute anterior uveitis (AAU) had higher VAS (P= 0.0008), BADSDAI (P= 0.0001), ASDAS-ESR (P= 0.04), CRP (P= 0.006), IL-6 (P= 0.02), and IL-18 (P= 0.03) levels. Patients with inflammatory bowel disease (IBD) had higher VAS (P= 0.03), CRP (P= 0.0009), and IL-6 (P= 0.0003) levels. Patients with skin psoriasis had lower VAS (P= 0.001) and BASDAI (P= 0.00007) levels. Patients with psoriatic onycholysis had lower VAS (P= 0.006), BASDAI (P= 0.00001), and CRP (P= 0.02) and higher IL-23 (P= 0.04) levels. Patients with PPP had lower BASDAI (P= 0.04) and higher ET-1 (P= 0.001) levels.Conclusions.SpA patients with increased serum IL-18 and decreased serum ET-1 had an increased risk of extra-articular symptoms. In SpA patients, increased disease activity was associated with an increased risk of AAU and IBD and a decreased risk of skin psoriasis, psoriatic onycholysis, and PPP.
authors.affiliation: Department of Rheumatology, Internal Medicine and Geriatrics, Pomeranian Medical University in Szczecin, Unii Lubelskiej 1, 71-252 Szczecin, Poland.
authors.forename: Hanna
authors.identifier: 0000-0001-6727-2594
authors.initials: H
authors.lastname: Przepiera-Będzak
authors.affiliation: Independent Laboratory of Rheumatic Diagnostics, Pomeranian Medical University in Szczecin, Unii Lubelskiej 1, 71-252 Szczecin, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Fischer
authors.affiliation: Department of Rheumatology, Internal Medicine and Geriatrics, Pomeranian Medical University in Szczecin, Unii Lubelskiej 1, 71-252 Szczecin, Poland.
authors.forename: Marek
authors.initials: M
authors.lastname: Brzosko
mesh_terms: D020083:Acquired Hyperostosis Syndrome / Q000097:blood*; D000328:Adult; D015535:Arthritis, Psoriatic / Q000097:blood*; D016207:Cytokines / Q000097:blood*; D019332:Endothelin-1 / Q000097:blood; D004815:Epidermal Growth Factor / Q000097:blood; D005260:Female; D006801:Humans; D020382:Interleukin-18 / Q000097:blood; D053759:Interleukin-23 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D012306:Risk; D013167:Spondylitis, Ankylosing / Q000097:blood*; D014606:Uveitis, Anterior / Q000097:blood; D042461:Vascular Endothelial Growth Factor A / Q000097:blood
chemical_list: D016207:Cytokines; D019332:Endothelin-1; C508600:IL6 protein, human; D020382:Interleukin-18; D053759:Interleukin-23; D015850:Interleukin-6; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D004815:Epidermal Growth Factor