title: Association of C5L2 genetic polymorphisms with coronary artery disease in a Han population in Xinjiang, China.
abstract: BACKGROUND
  C5aR-like receptor 2 (C5L2) has been identified as a receptor for the inflammatory factor Complement 5a (C5a) and acylation-stimulating protein (ASP). ASP binding to C5L2 leading to a net accumulation of TG stores and glucose transporter. The aim of the present study is to evaluate the association of the SNPs of C5L2 gene with coronary artery disease (CAD) in a Chinese population.
  
  
  METHODS
  We examined the role of the tagging single nucleotide polymorphisms (SNPs) of C5L2 gene for CAD using a case-control design. We determined the prevalence of C5L2 genotypes in 505 CAD patients and 469 age and sex-matched healthy control subjects of Han population.
  
  
  RESULTS
  There was significant difference in genotype distributions of rs2972607 and rs8112962 between CAD patients and control subjects. The rs2972607 was found to be associated with CAD in a dominant model (AA vs. AG + GG, P<0.001). Similarly, the rs8112962 was found to be associated with CAD in a dominant model (TT vs CT + CC, P=0.016). The difference remained statistically significant after multivariate adjustment (OR =1.401, 95% confidence interval [CI]:1.026~1.914, P=0.034; OR = 1.541, 95%CI:1.093~ 2.172, P=0.014; respectively).
  
  
  CONCLUSIONS
  The results of this study indicate that both rs2972607 and rs8112962 of C5L2 gene are associated with CAD in a Han population of China.
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054 P.R., China.|Coronary Heart Disease Laboratory, Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, 830054, P.R., China.
authors.forename: Ying-Ying
authors.initials: YY
authors.lastname: Zheng
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054 P.R., China.|Coronary Heart Disease Laboratory, Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, 830054, P.R., China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Xie
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054 P.R., China.|Coronary Heart Disease Laboratory, Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, 830054, P.R., China.
authors.forename: Yi-Tong
authors.initials: YT
authors.lastname: Ma
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054 P.R., China.|Coronary Heart Disease Laboratory, Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, 830054, P.R., China.
authors.forename: Zhen-Yan
authors.initials: ZY
authors.lastname: Fu
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054 P.R., China.|Coronary Heart Disease Laboratory, Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, 830054, P.R., China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Ma
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054 P.R., China.|Coronary Heart Disease Laboratory, Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, 830054, P.R., China.
authors.forename: Yi-Ning
authors.initials: YN
authors.lastname: Yang
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054 P.R., China.|Coronary Heart Disease Laboratory, Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, 830054, P.R., China.
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Li
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054 P.R., China.|Coronary Heart Disease Laboratory, Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, 830054, P.R., China.
authors.forename: Shuo
authors.initials: S
authors.lastname: Pan
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054 P.R., China.|Coronary Heart Disease Laboratory, Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, 830054, P.R., China.
authors.forename: Dilare
authors.initials: D
authors.lastname: Adi
authors.affiliation: Coronary Heart Disease Laboratory, Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, 830054, P.R., China.
authors.forename: Bang-Dang
authors.initials: BD
authors.lastname: Chen
authors.affiliation: Coronary Heart Disease Laboratory, Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, 830054, P.R., China.
authors.forename: Fen
authors.initials: F
authors.lastname: Liu
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002681:China; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D044087:Receptor, Anaphylatoxin C5a; D019707:Receptors, Chemokine / Q000235:genetics*; D012307:Risk Factors
chemical_list: C417003:C5aR2 protein, human; D005819:Genetic Markers; D044087:Receptor, Anaphylatoxin C5a; D019707:Receptors, Chemokine
keywords: C5L2 gene; acylation-stimulating protein; coronary artery disease; single nucleotide polymorphism