title: Relation of serum and vitreous nesfatin-1 concentrations with diabetic retinopathy.
abstract: OBJECTIVE
  Nesfatin-1, belonging to adipokine family, serves as an anti-inflammatory mediator. We performed this investigation to evaluate the relation between serum and vitreous nesfatin-1 concentrations with diabetic retinopathy (DR).
  
  
  METHODS
  This study was performed in a population of 189 diabetic patients and 48 control subjects. Diabetic patients were then divided into diabetic patients without DR, non-proliferative diabetic retinopathy (NPDR) patients, and proliferative diabetic retinopathy (PDR) patients.
  
  
  RESULTS
  Serum and vitreous nesfatin-1 concentrations were significantly lower in the diabetic patients than in the controls. NPDR patients had reduced vitreous nesfatin-1 concentrations compared with patients without DR. In addition, there were significantly lower serum and vitreous nesfatin-1 concentrations in PDR patients compared with the other three groups. Pearson correlation analysis showed that serum nesfatin-1 was negatively correlated with body mass index and fasting plasma glucose in diabetic patients.
  
  
  CONCLUSIONS
  Serum and vitreous nesfatin-1 concentrations were negatively correlated with DR.
authors.affiliation: Department of Endocrinology, The Third People's Hospital of Changzhou, Changzhou, China.
authors.forename: Rongfeng
authors.initials: R
authors.lastname: Dai
authors.affiliation: Department of Ophthalmology, The Third People's Hospital of Changzhou, Changzhou, China.
authors.forename: Guohua
authors.initials: G
authors.lastname: Deng
authors.affiliation: Department of Ophthalmology, The Third People's Hospital of Changzhou, Changzhou, China.
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Sun
authors.affiliation: Department of Ophthalmology, The Third People's Hospital of Changzhou, Changzhou, China.
authors.forename: Zhinan
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Endocrinology, The Third People's Hospital of Changzhou, Changzhou, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Qian
authors.affiliation: Department of Endocrinology, The Third People's Hospital of Changzhou, Changzhou, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Han
mesh_terms: D000368:Aged; D002135:Calcium-Binding Proteins / Q000032:analysis* / Q000097:blood / Q000378:metabolism; D016022:Case-Control Studies; D004268:DNA-Binding Proteins / Q000032:analysis* / Q000097:blood / Q000378:metabolism; D003930:Diabetic Retinopathy / Q000097:blood / Q000453:epidemiology* / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000032:analysis* / Q000097:blood / Q000378:metabolism; D000080866:Nucleobindins; D014822:Vitreous Body / Q000737:chemistry* / Q000378:metabolism
chemical_list: D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; C000630650:NUCB2 protein, human; D009419:Nerve Tissue Proteins; D000080866:Nucleobindins
keywords: angiogenesis; diabetic retinopathy; inflammation; nesfatin-1