title: Antiepileptic Drug Nonadherence and Its Predictors among People with Epilepsy.
abstract: Introduction.Antiepileptic drugs are effective in the treatment of epilepsy to the extent that about 70% of people with epilepsy can be seizure-free, but poor adherence to medication is major problem to sustained remission and functional restoration. The aim of this study was to assess the prevalence and associated factors of antiepileptic drug nonadherence.Methods.Cross-sectional study was conducted on 450 individuals who were selected by systematic random sampling method. Antiepileptic drug nonadherence was measured by Morisky Medication Adherence Scale (MMAS) and logistic regression was used to look for significant associations.Result.The prevalence of AEDs nonadherence was 37.8%. Being on treatment for 6 years and above [AOR = 3.47, 95% CI: 1.88, 6.40], payment for AEDs [AOR = 2.76, 95% CI: 1.73, 4.42], lack of health information [AOR = 2.20, 95% CI: 1.41,3.43], poor social support [AOR = 1.88, 95%, CI: 1.01, 3.50], perceived stigma [AOR = 2.27, 95% CI: 1.45, 3.56], and experience side effect [AOR = 1.70, 95% CI: 1.06, 2.72] were significantly associated with antiepileptic drug nonadherence.Conclusion.More than one-third of people with epilepsy were not compliant with their AEDs. Giving health information about epilepsy and its management and consequent reduction in stigma will help for medication adherence.
authors.affiliation: Finote Selam Hospital, Finote Selam, Ethiopia.
authors.forename: Asmamaw
authors.initials: A
authors.lastname: Getnet
authors.affiliation: Diseases Prevention and Control, School of Public Health, University of Queensland, Brisbane, QLD, Australia.
authors.forename: Solomon Meseret
authors.initials: SM
authors.lastname: Woldeyohannes
authors.affiliation: Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia.
authors.forename: Lulu
authors.initials: L
authors.lastname: Bekana
authors.affiliation: College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia.
authors.forename: Tesfa
authors.identifier: 0000-0002-3188-0173
authors.initials: T
authors.lastname: Mekonen
authors.affiliation: College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia.
authors.forename: Wubalem
authors.identifier: 0000-0003-0104-2133
authors.initials: W
authors.lastname: Fekadu
authors.affiliation: College of Health Sciences, Mizan Tepi University, Mizan, Ethiopia.
authors.forename: Melak
authors.initials: M
authors.lastname: Menberu
authors.affiliation: Psychiatry Department, College of Health Sciences and Medicine, Dilla University, Dilla, Ethiopia.
authors.forename: Solomon
authors.initials: S
authors.lastname: Yimer
authors.affiliation: Debre Markos University, Debre Markos, Ethiopia.
authors.forename: Adisu
authors.initials: A
authors.lastname: Assaye
authors.affiliation: College of Medicine and Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
authors.forename: Amsalu
authors.identifier: 0000-0003-3827-3955
authors.initials: A
authors.lastname: Belete
authors.affiliation: College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia.
authors.forename: Habte
authors.initials: H
authors.lastname: Belete
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000008:administration & dosage*; D003430:Cross-Sectional Studies; D004827:Epilepsy / Q000188:drug therapy* / Q000453:epidemiology / Q000523:psychology*; D005002:Ethiopia; D005260:Female; D005544:Forecasting; D006801:Humans; D008297:Male; D055118:Medication Adherence / Q000523:psychology*; D008875:Middle Aged; D010349:Patient Compliance / Q000523:psychology; D015995:Prevalence; D011795:Surveys and Questionnaires
chemical_list: D000927:Anticonvulsants