title: Identification and clinical course of 166 pediatric cardiac tumors.
abstract: The aim of this study was to investigate the pathological classifications, clinical features, and natural history of pediatric cardiac tumors to provide a basis for the selection of an appropriate therapeutic method. The medical records of in- or outpatients with cardiac tumors at four hospitals were classified to analyze various types of tumor growth locations, clinical manifestations, surgical indications, and long-term follow-up results. There were 166 patients, including 158 with primary cardiac tumors, six with metastatic cardiac tumors, and two with unclassified cardiac tumors. Among the 158 cases of primary cardiac tumor, 150 were benign and eight were malignant. The rhabdomyoma, fibroma, and myxoma are the most common types of benign cardiac tumors. The major clinical manifestations of cardiac tumors include outflow tract obstruction, arrhythmia, dyspnea, pericardial effusion, heart failure, and seizures. Among the 59 patients who underwent surgery, 49 had primary benign cardiac tumors, eight had primary malignant tumors, and two had malignant metastatic tumors. Post-surgery, nine of the patients had residual tumor tissues that did not significantly affect their hemodynamics. Following surgery, there were two cases of recurrence and nine deaths, including four of benign and five of malignant tumors with mortality rates of 8.2 and 50.0 %, respectively. Of the remaining 107 cases of patients who did not undergo surgery, five (4.7 %) died.
  
  
  CONCLUSIONS
  The primary benign cardiac tumors are the predominant pediatric cardiac tumors, of which rhabdomyoma, fibroma, and myxoma are the most common types. If severe symptoms are nonexistent and the hemodynamics is unaffected, most of the patients can survive in the long term despite the tumors. What is known: • Pediatric cardiac tumors are rare and are predominantly primary and benign. • The symptoms of heart failure, arrhythmia, and outflow obstruction are the most severe complications of cardiac tumors. What is new: • The rhabdomyoma, fibroma, and myxoma are the most common types of primary benign cardiac tumors. • If severe symptoms are not present and the hemodynamics are unaffected, most of the patients can survive in the long term despite the tumors.
authors.affiliation: Shanghai Children's Medical Center, Medical Institute, Shanghai Jiaotong University, Shanghai, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Shi
authors.affiliation: Shanghai Children's Medical Center, Medical Institute, Shanghai Jiaotong University, Shanghai, China.
authors.forename: Lanping
authors.initials: L
authors.lastname: Wu
authors.affiliation: , Shandong Provincial Hospital, Jinan, People's Republic of China.
authors.forename: Huijuan
authors.initials: H
authors.lastname: Fang
authors.affiliation: , Shandong Provincial Hospital, Jinan, People's Republic of China.
authors.forename: Bo
authors.initials: B
authors.lastname: Han
authors.affiliation: Children's Hospital, Fudan University, Shanghai, China.
authors.forename: Jialun
authors.initials: J
authors.lastname: Yang
authors.affiliation: Children's Hospital, Fudan University, Shanghai, China.
authors.forename: Xiaojin
authors.initials: X
authors.lastname: Ma
authors.affiliation: Children's Hospital, Fudan University, Shanghai, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
authors.affiliation: Shanghai Children's Hospital, Medical Institute, Shanghai Jiaotong University, Shanghai, China.
authors.forename: Yongwei
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Shanghai Children's Hospital, Medical Institute, Shanghai Jiaotong University, Shanghai, China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Xiao
authors.affiliation: Shanghai Children's Hospital, Medical Institute, Shanghai Jiaotong University, Shanghai, China.
authors.forename: Min
authors.initials: M
authors.lastname: Huang
authors.affiliation: Shanghai Children's Medical Center, Medical Institute, Shanghai Jiaotong University, Shanghai, China. huangmeirong128@sina.com.|Department of Pediatric Cardiology, Shanghai Children's Medical Center, Medical Institute, Shanghai Jiao Tong University, 1678, Dongfang Road, Shanghai, 200127, China. huangmeirong128@sina.com.
authors.forename: Meirong
authors.initials: M
authors.lastname: Huang
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D005350:Fibroma / Q000175:diagnosis* / Q000453:epidemiology / Q000601:surgery; D005500:Follow-Up Studies; D006338:Heart Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000601:surgery; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009232:Myxoma / Q000175:diagnosis* / Q000453:epidemiology / Q000601:surgery; D012189:Retrospective Studies; D012207:Rhabdomyoma / Q000175:diagnosis* / Q000453:epidemiology / Q000601:surgery
keywords: Classification of the cardiac tumors; Metastatic malignant tumor; Pediatric cardiac tumor; Primary benign cardiac tumor; Primary malignant cardiac tumor