title: microRNAs-based Predictor Factor in Patients with Migraine-ischemic Stroke.
abstract: Among the clinical spectrum of neurological diseases, migraine is often associated with cerebro-vasculopathy. Impairment of neuroimmune mediators in the central nervous system has been recognized in the pathophysiology of migraine-related stroke. Although genetic correlation was found in patients with migraine-related stroke, the epidemiology of this disease indicates a need in biomarker searching discovery and validation. In this view, small molecule, called microRNAs (miRNAs), able to regulate immune and neuronal processes has been reported in patients with migraine and ischemic stroke and unambiguous miRNAs related to these diseases could be established as new molecular indicator of precocity for clinical and/or pharmacological intervention. Therefore, further exploration of this area is necessary, as greater understanding of these biomarkers could reveal the common mechanisms involved in the pathophysiology of migraine in patients with cerebral infarct.
authors.affiliation: University of Catanzaro, Clinical Pharmacology Unit, Mater Domini University Hospital - Chair of Pharmacology, Department of Health Science, School of Medicine, Catanzaro. Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Gallelli
authors.affiliation: Department of Neurology, Annunziata Hospital Via F. Migliori, 1; 87100 Cosenza. Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Siniscalchi
authors.affiliation: Clinic of Child and Adolescent Neuropsychiatry; Department of Mental Health, Physical and Preventive Medicine; Second University of Naples, Naples. Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Carotenuto
authors.affiliation: Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende (CS). Italy.
authors.forename: Maria C
authors.initials: MC
authors.lastname: Caroleo
authors.affiliation: Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende (CS). Italy.
authors.forename: Erika
authors.initials: E
authors.lastname: Cione
authors.affiliation: Department of Pediatrics and Child and Adolescent Neuropsychiatry, Sapienza University of Rome, Rome. Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Guidetti
mesh_terms: D000818:Animals; D015415:Biomarkers; D002545:Brain Ischemia / Q000150:complications* / Q000235:genetics*; D005786:Gene Expression Regulation; D020022:Genetic Predisposition to Disease; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D008881:Migraine Disorders / Q000150:complications* / Q000235:genetics*; D011379:Prognosis; D020521:Stroke / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy
chemical_list: D015415:Biomarkers; D035683:MicroRNAs
keywords: Cerebral infarct; cerebrovascular diseases; microRNA; migraine; neurological diseases; pathophysiology