title: Prior knowledge is essential for the beneficial effect of targeted memory reactivation during sleep.
abstract: Prior knowledge speeds up system consolidation and accelerates integration of newly acquired memories into existing neocortical knowledge networks. By using targeted memory reactivations, we demonstrate that prior knowledge is also essential for successful reactivation and consolidation of memories during sleep, both on the behavioral and oscillatory level (i.e., theta and fast spindle activity). Thus, prior knowledge is a prerequisite for new memories to enter processes of system consolidation during sleep.
authors.affiliation: University Children's Hospital Zürich, Zürich, Switzerland.
authors.forename: Sabine
authors.initials: S
authors.lastname: Groch
authors.affiliation: Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, The Netherlands.|Department of Psychology, University of Fribourg, Switzerland.
authors.forename: Thomas
authors.initials: T
authors.lastname: Schreiner
authors.affiliation: Department of Psychology, University of Fribourg, Switzerland.
authors.forename: Björn
authors.initials: B
authors.lastname: Rasch
authors.affiliation: University Children's Hospital Zürich, Zürich, Switzerland.|Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric Hospital, University of Zürich, Switzerland.
authors.forename: Reto
authors.initials: R
authors.lastname: Huber
authors.affiliation: University Children's Hospital Zürich, Zürich, Switzerland.|Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zürich, Switzerland.|Department of Psychology, University of Zürich, Switzerland.
authors.forename: Ines
authors.initials: I
authors.lastname: Wilhelm
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000502:physiology*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D019359:Knowledge; D007858:Learning; D008297:Male; D008568:Memory / Q000502:physiology*; D000069077:Memory Consolidation; D009483:Neuropsychological Tests; D012890:Sleep / Q000502:physiology*; D014851:Wakefulness / Q000502:physiology*; D055815:Young Adult