title: Aflatoxin B1Induced Systemic Toxicity in Poultry and Rescue Effects of Selenium and Zinc.
abstract: Among many challenges, exposure to aflatoxins, particularly aflatoxin B1(AFB1), is one of the major concerns in poultry industry. AFB1intoxication results in decreased meat/egg production, hepatotoxicity, nephrotoxicity, disturbance in gastrointestinal tract (GIT) and reproduction, immune suppression, and increased disease susceptibility. Selenium (Se) and zinc (Zn), in dietary supplementation, offer easy, cost-effective, and efficient ways to neutralize the toxic effect of AFB1. In the current review, we discussed the impact of AFB1on poultry industry, its biotransformation, and organ-specific noxious effects, along with the action mechanism of AFB1-induced toxicity. Moreover, we explained the biological and detoxifying roles of Se and Zn in avian species as well as the protection mechanism of these two trace elements. Ultimately, we discussed the use of Se and Zn supplementation against AFB1-induced toxicity in poultry birds.
authors.affiliation: Keys Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, People's Republic of China.
authors.forename: Muhammad Jameel
authors.initials: MJ
authors.lastname: Mughal
authors.affiliation: Key Laboratory of Southwest China Wildlife Resources Conservation (Ministry of Education), College of Life Sciences, China West Normal University, Nanchong, Sichuan, People's Republic of China. pengxi197313@163.com.
authors.forename: Xi
authors.initials: X
authors.lastname: Peng
authors.affiliation: Department of Veterinary Microbiology, Sindh Agriculture University Tandojam, Tandojam, Pakistan.
authors.forename: Asghar Ali
authors.initials: AA
authors.lastname: Kamboh
authors.affiliation: Life Science Department, Sichuan Agricultural University, Yaan, Sichuan, People's Republic of China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Keys Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, People's Republic of China. fangjing4109@163.com.
authors.forename: Jing
authors.initials: J
authors.lastname: Fang
mesh_terms: D016604:Aflatoxin B1 / Q000633:toxicity*; D000818:Animals; D011200:Poultry / Q000378:metabolism*; D011201:Poultry Diseases / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control; D012643:Selenium / Q000627:therapeutic use*; D015032:Zinc / Q000627:therapeutic use*
chemical_list: D016604:Aflatoxin B1; D012643:Selenium; D015032:Zinc
keywords: Aflatoxin B1; Detoxification; Poultry; Se; Supplementation; Zinc