title: CRYPTOCHROME mediates behavioral executive choice in response to UV light.
abstract: Drosophila melanogaster CRYPTOCHROME (CRY) mediates behavioral and electrophysiological responses to blue light coded by circadian and arousal neurons. However, spectroscopic and biochemical assays of heterologously expressed CRY suggest that CRY may mediate functional responses to UV-A (ultraviolet A) light as well. To determine the relative contributions of distinct phototransduction systems, we tested mutants lacking CRY and mutants with disrupted opsin-based phototransduction for behavioral and electrophysiological responses to UV light. CRY and opsin-based external photoreceptor systems cooperate for UV light-evoked acute responses. CRY mediates behavioral avoidance responses related to executive choice, consistent with its expression in central brain neurons.
authors.affiliation: Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA 92697.
authors.forename: Lisa S
authors.initials: LS
authors.lastname: Baik
authors.affiliation: Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA 92697.
authors.forename: Keri J
authors.initials: KJ
authors.lastname: Fogle
authors.affiliation: Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA 92697.
authors.forename: Logan
authors.initials: L
authors.lastname: Roberts
authors.affiliation: Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA 92697.
authors.forename: Alexis M
authors.initials: AM
authors.lastname: Galschiodt
authors.affiliation: Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA 92697.
authors.forename: Joshua A
authors.initials: JA
authors.lastname: Chevez
authors.affiliation: Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA 92697.
authors.forename: Yocelyn
authors.initials: Y
authors.lastname: Recinos
authors.affiliation: Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA 92697.
authors.forename: Vinh
authors.initials: V
authors.lastname: Nguy
authors.affiliation: Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA 92697 tholmes@uci.edu.
authors.forename: Todd C
authors.initials: TC
authors.lastname: Holmes
mesh_terms: D000818:Animals; D001683:Biological Clocks / Q000502:physiology; D002490:Central Nervous System / Q000378:metabolism / Q000502:physiology; D002755:Choice Behavior / Q000502:physiology*; D002940:Circadian Rhythm / Q000502:physiology; D056931:Cryptochromes / Q000378:metabolism*; D029721:Drosophila Proteins / Q000378:metabolism; D004331:Drosophila melanogaster / Q000378:metabolism / Q000502:physiology; D005136:Eye Proteins / Q000378:metabolism; D008027:Light; D055537:Light Signal Transduction / Q000502:physiology; D009474:Neurons / Q000378:metabolism; D017956:Photoreceptor Cells, Invertebrate / Q000378:metabolism; D014466:Ultraviolet Rays
chemical_list: D056931:Cryptochromes; D029721:Drosophila Proteins; D005136:Eye Proteins
keywords: Drosophila; UV; cryptochrome; neural decision making; phototransduction