title: The Diagnostic Usefulness of Serum Total Bile Acid Concentrations in the Early Phase of Acute Pancreatitis of Varied Etiologies.
abstract: The most common causes of acute pancreatitis (AP) are biliary tract diseases with cholestasis and alcohol consumption. In 10%-15% of patients, etiology determination is difficult. Identification of the etiology allows for the implementation of adequate treatment. The aim of this study was to assess the utility of the serum concentrations of total bile acids (TBA) to diagnose AP etiology in the early phase of the disease. We included 66 patients with AP, admitted within the first 24 h from the onset of symptoms. TBA were measured in serum at 24, 48, and 72 h from the onset of AP, using an automated fifth generation assay. The bilirubin-to-TBA ratio (B/TBA) was calculated. TBA was highest on the first day of AP and decreased subsequently. In patients with biliary etiology, serum TBA was significantly higher compared to those with alcoholic and other etiologies. B/TBA was significantly higher in patients with alcoholic etiology. At admission, the cut-off values of 4.7 µmol/L for TBA and 4.22 for the B/TBA ratio allowed for a differentiation between biliary and other etiologies of AP with a diagnostic accuracy of 85 and 83%. Both TBA and B/TBA may help in the diagnosis of AP etiology in the early phase of AP.
authors.affiliation: Department of Diagnostics, University Hospital, 31-501 Kraków, Poland. amaleszka@su.krakow.pl.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Maleszka
authors.affiliation: Department of Medical Diagnostics, Jagiellonian University Medical College, 30-688 Kraków, Poland. paulina.dumnicka@uj.edu.pl.
authors.forename: Paulina
authors.initials: P
authors.lastname: Dumnicka
authors.affiliation: Department of Anatomy, Jagiellonian University Medical College, 31-034 Kraków, Poland. aleksandra.matuszyk@uj.edu.pl.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Matuszyk
authors.affiliation: 2nd Department of Surgery, Jagiellonian University Medical College, 31-501 Kraków, Poland. michal.pedziwiatr@uj.edu.pl.
authors.forename: Michał
authors.initials: M
authors.lastname: Pędziwiatr
authors.affiliation: Department of Diagnostics, University Hospital, 31-501 Kraków, Poland. mbmazur@cyf-kr.edu.pl.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Mazur-Laskowska
authors.affiliation: Department of Anatomy, Jagiellonian University Medical College, 31-034 Kraków, Poland. msporek1983@gmail.com.|Surgery Department, The District Hospital, 34-200 Sucha Beskidzka, Poland. msporek1983@gmail.com.
authors.forename: Mateusz
authors.initials: M
authors.lastname: Sporek
authors.affiliation: Department of Physiology, Jagiellonian University Medical College, 31-531 Kraków, Poland. piotr.ceranowicz@uj.edu.pl.
authors.forename: Piotr
authors.initials: P
authors.lastname: Ceranowicz
authors.affiliation: Department of Pharmacology, Jagiellonian University Medical College, 31-531 Kraków, Poland. rafal.olszanecki@uj.edu.pl.
authors.forename: Rafał
authors.initials: R
authors.lastname: Olszanecki
authors.affiliation: Chair and Department of Nephrology, Jagiellonian University Medical College, 31-501 Kraków, Poland. marek.kuzniewski@uj.edu.pl.
authors.forename: Marek
authors.initials: M
authors.lastname: Kuźniewski
authors.affiliation: Department of Diagnostics, Chair of Clinical Biochemistry, Jagiellonian University Medical College, 31-501 Kraków, Poland. mbkusnie@cyf-kr.edu.pl.
authors.forename: Beata
authors.initials: B
authors.lastname: Kuśnierz-Cabala
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D001647:Bile Acids and Salts / Q000097:blood*; D001663:Bilirubin / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000097:blood* / Q000175:diagnosis* / Q000209:etiology
chemical_list: D001647:Bile Acids and Salts; D001663:Bilirubin
keywords: biliary acute pancreatitis; idiopathic acute pancreatitis; total bile acids