title: Antibacterial Bioactive Glass, S53P4, for Chronic Bone Infections - A Multinational Study.
abstract: Osteomyelitis is an infectious process in bone that occasionally leads to bone destruction. Traditionally, the surgical treatment procedure is performed in combination with systemic and local antibiotics as a two-stage procedure that uses autograft or allograft bone for filling of the cavitary defect. Bioactive glass (BAG-S53P4) is a bone substitute with proven antibacterial and bone bonding properties.One hundred and sixteen patients who had verified chronic osteomyelitis was treated using BAG-S53P4 as part of the treatment. Most of the patients had previously undergone numerous procedures, sometimes for decades. A register of patient data obtained from 11 centers from Finland, Italy, the Netherlands, Germany, Azerbaijan and Poland was set-up and continuously maintained at Helsinki University Central Hospital.The location of the osteomyelitis was mainly in the tibia followed by the femur and then the calcaneus. The median age of the patients was 48 years (15-87). The patients were either treated according to a one-stage procedure without local antibiotics (85 %) or by a two-stage procedure using antibiotic beads in the first procedure (15 %). The minimum follow-up was 1 year (12-95 months, median 31).The cure rate was 104/116, the total success rate 90 % and most of the patients showed a rapid recovery.The study shows that (BAG-S53P4) can be used in a one-stage procedure in treatment of osteomyelitis with excellent results.
authors.affiliation: Department of Orthopaedic and Plastic Surgery, Helsinki University Central Hospital, Helsinki University, Helsinki, Finland. nina.c.lindfors@hus.fi.
authors.forename: Nina
authors.initials: N
authors.lastname: Lindfors
authors.affiliation: Department of Orthopaedic Surgery, Research School CAPHRI, Maastricht University Medical Centre, Maastricht, The Netherlands.
authors.forename: Jan
authors.initials: J
authors.lastname: Geurts
authors.affiliation: Laboratory of Clinical Chemistry and Microbiology, I.R.C.C.S. Galeazzi Orthopaedic Institute, Milan, Italy.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Drago
authors.affiliation: Department of Orthopaedic Surgery, Research School CAPHRI, Maastricht University Medical Centre, Maastricht, The Netherlands.|Orthopaedic Biomechanics Group, Department of Biomedical Engineering, Eindhoven University of Technology (TU/e), Eindhoven, The Netherlands.
authors.forename: J J
authors.initials: JJ
authors.lastname: Arts
authors.affiliation: Department of Orthopaedic and Plastic Surgery, Helsinki University Central Hospital, Helsinki University, Helsinki, Finland.
authors.forename: Vesa
authors.initials: V
authors.lastname: Juutilainen
authors.affiliation: Department of Orthopaedic and Traumatology, Oulu University Hospital, Oulu, Finland.
authors.forename: Pekka
authors.initials: P
authors.lastname: Hyvönen
authors.affiliation: Department for Septic Surgery, BG Trauma Center Ludwigshafen, Ludwigshafen, Germany.
authors.forename: Arnold J
authors.initials: AJ
authors.lastname: Suda
authors.affiliation: I Orthopaedic Clinic, University of Turin, Orthopaedic and Trauma Center - CTO Hospital, Turin, Italy.
authors.forename: Aloj
authors.initials: A
authors.lastname: Domenico
authors.affiliation: I Orthopaedic Clinic, University of Turin, Orthopaedic and Trauma Center - CTO Hospital, Turin, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Artiaco
authors.affiliation: Azerbaijan Scientific Research Institute of Traumatology and Orthopaedics, Baku, Azerbaijan.
authors.forename: Chingiz
authors.initials: C
authors.lastname: Alizadeh
authors.affiliation: Department of Bone and Joint Infections, Orthopedic Clinic of Postgraduate Medical Education Centre, Otwock, Poland.
authors.forename: Adrian
authors.initials: A
authors.lastname: Brychcy
authors.affiliation: Department of Bone and Joint Infections, Orthopedic Clinic of Postgraduate Medical Education Centre, Otwock, Poland.
authors.forename: Jertzy
authors.initials: J
authors.lastname: Bialecki
authors.affiliation: Center for Reconstructive Surgery of Osteoarticular Infections (CRIO), I.R.C.C.S. Galeazzi Orthopaedic Institute, Milan, Italy.
authors.forename: Carlo L
authors.initials: CL
authors.lastname: Romanò
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D018786:Bone Substitutes / Q000627:therapeutic use*; D001842:Bone and Bones / Q000187:drug effects*; D002908:Chronic Disease / Q000188:drug therapy*; D005260:Female; D005898:Glass / Q000737:chemistry*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010019:Osteomyelitis / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents; D018786:Bone Substitutes; C403922:bioactive glass S53P4
keywords: Antibacterial; Bioactive glass; Bone substitute; Osteomyelitis; S53P4