title: Manganese-Catalyzed Multicomponent Synthesis of Pyrimidines from Alcohols and Amidines.
abstract: The development of catalytic reactions for synthesizing different compounds from alcohols to save fossil carbon feedstock and reduce CO2emissions is of high importance. Replacing rare noble metals with abundantly available 3d metals is equally important. We report a manganese-complex-catalyzed multicomponent synthesis of pyrimidines from amidines and up to three alcohols. Our reaction proceeds through condensation and dehydrogenation steps, permitting selective C-C and C-N bond formations. β-Alkylation reactions are used to multiply alkylate secondary alcohols with two different primary alcohols to synthesize fully substituted pyrimidines in a one-pot process. Our PN5P-Mn-pincer complexes efficiently catalyze this multicomponent process. A comparison of our manganese catalysts with related cobalt catalysts indicates that manganese shows a reactivity similar to that of iridium but not cobalt. This analogy could be used to develop further (de)hydrogenation reactions with manganese complexes.
authors.affiliation: Anorganische Chemie II-Katalysatordesign, Universität Bayreuth, 95447, Bayreuth, Germany.
authors.forename: Nicklas
authors.initials: N
authors.lastname: Deibl
authors.affiliation: Anorganische Chemie II-Katalysatordesign, Universität Bayreuth, 95447, Bayreuth, Germany.
authors.forename: Rhett
authors.initials: R
authors.lastname: Kempe
keywords: borrowing-hydrogen reactions; dehydrogenative coupling; maganese; pincer complexes; pyrimidines