title: Nephrotic Syndrome in Small Cell Lung Cancer and Induction of C-Mip in Podocytes.
abstract: Paraneoplastic nephrotic syndrome is often a complication in patients with cancer, and various histologic lesions have been described in the kidney. We report the case of a 76-year-old woman who presented with a podocytopathy that was found to be associated with a small cell lung carcinoma (SCLC). One cycle of carboplatin-etoposide combination therapy led to resolution of nephrotic syndrome and remission of the lung carcinoma. C-Maf-inducing protein (C-Mip) was overexpressed in both podocytes and cancer cells, but was not found in control kidney and lung tissue samples. C-Mip also was absent in SCLC cells from 30 patients without nephrotic syndrome. Exposing cultured podocytes to a sample of our patient's serum that was collected prior to chemotherapy led to disorganization of the podocyte cytoskeleton and induction of C-Mip expression, which was not observed with control serum or our patient's serum sampled after chemotherapy. These observations suggest that C-Mip may play an important role in SCLC-related podocytopathy and that a circulating factor likely induces its expression in the kidney.
authors.affiliation: Division of Nephrology, Geneva University Hospitals, Geneva, Switzerland.
authors.forename: Yassine
authors.initials: Y
authors.lastname: Bouatou
authors.affiliation: Division of Oncology, Geneva University Hospitals, Geneva, Switzerland.
authors.forename: Thibaud
authors.initials: T
authors.lastname: Koessler
authors.affiliation: INSERM, U955, Equipe 21, Créteil, France; Université Paris-Est Créteil Val-de-Marne, Créteil, France; AP-HP, Groupe Hospitalier Henri Mondor-Albert Chenevier, Service de Néphrologie, Créteil, France.
authors.forename: Julie
authors.initials: J
authors.lastname: Oniszczuk
authors.affiliation: INSERM, U955, Equipe 21, Créteil, France; Université Paris-Est Créteil Val-de-Marne, Créteil, France; AP-HP, Groupe Hospitalier Henri Mondor-Albert Chenevier, Service de Néphrologie, Créteil, France.
authors.forename: Shao-Yu
authors.initials: SY
authors.lastname: Zhang
authors.affiliation: Division of Pathology, Geneva University Hospitals, Geneva, Switzerland.
authors.forename: Solange
authors.initials: S
authors.lastname: Moll
authors.affiliation: INSERM, U955, Equipe 21, Créteil, France; Université Paris-Est Créteil Val-de-Marne, Créteil, France; AP-HP, Groupe Hospitalier Henri Mondor-Albert Chenevier, Service de Néphrologie, Créteil, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Audard
authors.affiliation: Division of Nephrology, Geneva University Hospitals, Geneva, Switzerland. Electronic address: sophie.deseigneux@hcuge.ch.
authors.forename: Sophie
authors.initials: S
authors.lastname: de Seigneux
authors.affiliation: INSERM, U955, Equipe 21, Créteil, France; Université Paris-Est Créteil Val-de-Marne, Créteil, France; AP-HP, Groupe Hospitalier Henri Mondor-Albert Chenevier, Service de Néphrologie, Créteil, France. Electronic address: dil.sahali@inserm.fr.
authors.forename: Djillali
authors.initials: D
authors.lastname: Sahali
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000502:physiology*; D000368:Aged; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications*; D009404:Nephrotic Syndrome / Q000209:etiology*; D050199:Podocytes; D055752:Small Cell Lung Carcinoma / Q000150:complications*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C540426:CMIP protein, human
keywords: C-Maf inducing protein; C-Mip; Paraneoplastic nephrotic syndrome; case report; kidney biopsy; nephrotic syndrome (NS); podocyte cytoskeleton; podocytopathy; proteinuria; small cell lung cancer (SCLC)