title: Alkaloids and Phenolic Compounds from Sida rhombifolia L. (Malvaceae) and Vasorelaxant Activity of Two Indoquinoline Alkaloids.
abstract: The follow-up of phytochemical and pharmacological studies ofSida rhombifoliaL. (Malvaceae) aims to strengthen the chemosystematics and pharmacology ofSidagenera and support the ethnopharmacological use of this species as hypotensive herb. The present work reports phytoconstituents isolated and identified from aerial parts ofS. rhombifoliaby using chromatographic and spectroscopic methods. The study led to the isolation of scopoletin (1), scoporone (2), ethoxy-ferulate (3), kaempferol (4), kaempferol-3-O-β-d-glycosyl-6''-α-d-rhamnose (5), quindolinone (6), 11-methoxy-quindoline (7), quindoline (8), and the cryptolepine salt (9). The alkaloids quindolinone (6) and cryptolepine salt (9) showed vasorelaxant activity in rodent isolated mesenteric arteries.
authors.affiliation: Post Graduation Program in Bioactive Natural and Synthetic Products, Health Sciences Center, Federal University of Paraíba, 58051-970 João Pessoa, PB, Brazil. otembergsc@ltf.ufpb.br.
authors.forename: Otemberg Souza
authors.initials: OS
authors.lastname: Chaves
authors.affiliation: Post Graduation in Development and Technological Innovation in Medicines, Federal University of Paraiba, 58051-900 João Pessoa, PB, Brazil. yannateles@gmail.com.|Department of Chemistry and Physics, Agrarian Sciences Center, Federal University of Paraíba, 58397-972 Areia, PB, Brazil. yannateles@gmail.com.
authors.forename: Yanna Carolina Ferreira
authors.initials: YC
authors.lastname: Teles
authors.affiliation: Post Graduation Program in Bioactive Natural and Synthetic Products, Health Sciences Center, Federal University of Paraíba, 58051-970 João Pessoa, PB, Brazil. monteirommo@gmail.com.
authors.forename: Matheus Morais de Oliveira
authors.initials: MM
authors.lastname: Monteiro
authors.affiliation: Post Graduation Program in Bioactive Natural and Synthetic Products, Health Sciences Center, Federal University of Paraíba, 58051-970 João Pessoa, PB, Brazil. leonidasjunior@ltf.ufpb.br.
authors.forename: Leônidas das Graças
authors.initials: LD
authors.lastname: Mendes Junior
authors.affiliation: Post Graduation Program in Bioactive Natural and Synthetic Products, Health Sciences Center, Federal University of Paraíba, 58051-970 João Pessoa, PB, Brazil. agramf@ltf.ufpb.br.
authors.forename: Maria de Fátima
authors.initials: MF
authors.lastname: Agra
authors.affiliation: Post Graduation Program in Bioactive Natural and Synthetic Products, Health Sciences Center, Federal University of Paraíba, 58051-970 João Pessoa, PB, Brazil. valdir@cbiotec.ufpb.br.
authors.forename: Valdir de Andrade
authors.initials: VA
authors.lastname: Braga
authors.affiliation: Department of Molecular Sciences, Federal Rural University of Pernambuco, Campus Dois Irmãos, 52171-900 Recife, PE, Brazil. sarmentosilva@gmail.com.
authors.forename: Tânia Maria Sarmento
authors.initials: TM
authors.lastname: Silva
authors.affiliation: Post Graduation Program in Bioactive Natural and Synthetic Products, Health Sciences Center, Federal University of Paraíba, 58051-970 João Pessoa, PB, Brazil. mfvanderlei@ltf.ufpb.br.|Post Graduation in Development and Technological Innovation in Medicines, Federal University of Paraiba, 58051-900 João Pessoa, PB, Brazil. mfvanderlei@ltf.ufpb.br.
authors.forename: Maria de Fátima Vanderlei de
authors.initials: MF
authors.lastname: Souza
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D000959:Antihypertensive Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D019660:Malvaceae / Q000737:chemistry*; D008638:Mesenteric Arteries / Q000187:drug effects / Q000502:physiology; D010636:Phenols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D064209:Phytochemicals / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry; D051381:Rats; D046509:Tissue Culture Techniques; D014665:Vasodilator Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000470:Alkaloids; D000959:Antihypertensive Agents; D003374:Coumarins; D005419:Flavonoids; D010636:Phenols; D064209:Phytochemicals; D010936:Plant Extracts; D014665:Vasodilator Agents
keywords: Malvaceae; Sida rhombifolia; indoquinoline alkaloids; vasorelaxant activity