title: Pharmacological and clinical profile of a novel dual endothelin receptor antagonist, macitentan (Opsumit®).
authors.forename: Shuya
authors.initials: S
authors.lastname: Takahashi
authors.forename: Ritsuko
authors.initials: R
authors.lastname: Horie
authors.forename: Yoshinari
authors.initials: Y
authors.lastname: Yokoyama
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D065128:Endothelin Receptor Antagonists / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy; D011743:Pyrimidines / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D044022:Receptor, Endothelin A / Q000378:metabolism; D044023:Receptor, Endothelin B / Q000378:metabolism; D013449:Sulfonamides / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D065128:Endothelin Receptor Antagonists; D011743:Pyrimidines; D044022:Receptor, Endothelin A; D044023:Receptor, Endothelin B; D013449:Sulfonamides; C533860:macitentan