title: Quantitative Characterization of the Toxicities of Cd-Ni and Cd-Cr Binary Mixtures Using Combination Index Method.
abstract: Direct equipartition ray design was used to construct Cd-Ni and Cd-Cr binary mixtures. Microplate toxicity analysis was used to evaluate the toxicity of individual substance and the Cd-Ni and Cd-Cr mixtures onChlorella pyrenoidosaandSelenastrum capricornutum. The interacting toxicity of the mixture was analyzed with concentration addition (CA) model. In addition, combination index method (CI) was proposed and used to quantitatively characterize the toxicity of the binary mixtures of Cd-Ni and Cd-Cr observed in experiment and find the degree of deviation from the predicted outcome of the CA model, that is, the intensity of interacting toxicity. Results indicate that most of the 20 binary mixtures exhibit enhancing and synergistic effect, and only Cd-Cr-R4 and Cd-Cr-R5 mixtures have relatively high antagonistic effects againstC. pyrenoidosa. Based on confidence interval, CI can compare the intensities of interaction of the mixtures under varying levels of effect. The characterization methods are applicable for analyzing binary mixture with complex interaction.
authors.affiliation: Guangxi Key Laboratory of Environmental Pollution Control Theory and Technology, Guilin University of Technology, Guilin 541004, China; Collaborative Innovation Center for Water Pollution Control and Water Safety in Karst Area, Guilin University of Technology, Guilin 541004, China.
authors.forename: Lingyun
authors.identifier: 0000-0002-1592-8210
authors.initials: L
authors.lastname: Mo
authors.affiliation: Guangxi Key Laboratory of Environmental Pollution Control Theory and Technology, Guilin University of Technology, Guilin 541004, China; Collaborative Innovation Center for Water Pollution Control and Water Safety in Karst Area, Guilin University of Technology, Guilin 541004, China.
authors.forename: Minyi
authors.initials: M
authors.lastname: Zheng
authors.affiliation: Guangxi Key Laboratory of Environmental Pollution Control Theory and Technology, Guilin University of Technology, Guilin 541004, China; Collaborative Innovation Center for Water Pollution Control and Water Safety in Karst Area, Guilin University of Technology, Guilin 541004, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Qin
authors.affiliation: Guangxi Key Laboratory of Environmental Pollution Control Theory and Technology, Guilin University of Technology, Guilin 541004, China; Collaborative Innovation Center for Water Pollution Control and Water Safety in Karst Area, Guilin University of Technology, Guilin 541004, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Guangxi Key Laboratory of Environmental Pollution Control Theory and Technology, Guilin University of Technology, Guilin 541004, China; Collaborative Innovation Center for Water Pollution Control and Water Safety in Karst Area, Guilin University of Technology, Guilin 541004, China.
authors.forename: Jie
authors.identifier: 0000-0002-7462-3441
authors.initials: J
authors.lastname: Liu
authors.affiliation: Guangxi Key Laboratory of Environmental Pollution Control Theory and Technology, Guilin University of Technology, Guilin 541004, China; Collaborative Innovation Center for Water Pollution Control and Water Safety in Karst Area, Guilin University of Technology, Guilin 541004, China.
authors.forename: Litang
authors.identifier: 0000-0003-1910-403X
authors.initials: L
authors.lastname: Qin
authors.affiliation: Guangxi Key Laboratory of Environmental Pollution Control Theory and Technology, Guilin University of Technology, Guilin 541004, China; Collaborative Innovation Center for Water Pollution Control and Water Safety in Karst Area, Guilin University of Technology, Guilin 541004, China.
authors.forename: Honghu
authors.initials: H
authors.lastname: Zeng
authors.affiliation: Guangxi Key Laboratory of Environmental Pollution Control Theory and Technology, Guilin University of Technology, Guilin 541004, China; Collaborative Innovation Center for Water Pollution Control and Water Safety in Karst Area, Guilin University of Technology, Guilin 541004, China.
authors.forename: Yanpeng
authors.initials: Y
authors.lastname: Liang
mesh_terms: D002104:Cadmium / Q000737:chemistry* / Q000633:toxicity*; D002708:Chlorella / Q000187:drug effects; D002857:Chromium / Q000737:chemistry* / Q000633:toxicity*; D009532:Nickel / Q000737:chemistry* / Q000633:toxicity*; D018675:Toxicity Tests / Q000379:methods
chemical_list: D002104:Cadmium; D002857:Chromium; D009532:Nickel