title: The neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster Crassostrea gigas.
abstract: The neuroendocrine-immune (NEI) regulatory network is a complex system, which plays an indispensable role in the immunity of host. In this study, a neuroendocrine immunomodulatory axis (NIA)-like pathway mediated by the nervous system and haemocytes was characterized in the oyster Crassostrea gigas Once invaded pathogen was recognized by the host, the nervous system would temporally release neurotransmitters to modulate the immune response. Instead of acting passively, oyster haemocytes were able to mediate neuronal immunomodulation promptly by controlling the expression of specific neurotransmitter receptors on cell surface and modulating their binding sensitivities, thus regulating intracellular concentration of Ca2+This neural immunomodulation mediated by the nervous system and haemocytes could influence cellular immunity in oyster by affecting mRNA expression level of TNF genes, and humoral immunity by affecting the activities of key immune-related enzymes. In summary, though simple in structure, the 'nervous-haemocyte' NIA-like pathway regulates both cellular and humoral immunity in oyster, meaning a world to the effective immune regulation of the NEI network.
authors.affiliation: Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, People's Republic of China.|University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
authors.forename: Zhaoqun
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, People's Republic of China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Zhou
authors.affiliation: Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, People's Republic of China.
authors.forename: Qiufen
authors.initials: Q
authors.lastname: Jiang
authors.affiliation: Key Laboratory of Mariculture and Stock Enhancement in North China's Sea, Ministry of Agriculture, Dalian Ocean University, Dalian 116023, People's Republic of China wanglingling@dlou.edu.cn.
authors.forename: Lingling
authors.identifier: 0000-0002-1049-9170
authors.initials: L
authors.lastname: Wang
authors.affiliation: Key Laboratory of Mariculture and Stock Enhancement in North China's Sea, Ministry of Agriculture, Dalian Ocean University, Dalian 116023, People's Republic of China.
authors.forename: Qilin
authors.initials: Q
authors.lastname: Yi
authors.affiliation: Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, People's Republic of China.
authors.forename: Limei
authors.initials: L
authors.lastname: Qiu
authors.affiliation: Key Laboratory of Mariculture and Stock Enhancement in North China's Sea, Ministry of Agriculture, Dalian Ocean University, Dalian 116023, People's Republic of China.
authors.forename: Linsheng
authors.initials: L
authors.lastname: Song
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D002478:Cells, Cultured; D049896:Crassostrea / Q000166:cytology* / Q000235:genetics / Q000276:immunology; D006434:Hemocytes / Q000166:cytology* / Q000276:immunology; D056747:Immunomodulation; D008070:Lipopolysaccharides / Q000009:adverse effects; D009490:Neurosecretory Systems / Q000378:metabolism*; D010587:Phagocytosis; D017981:Receptors, Neurotransmitter / Q000235:genetics; D048069:Tumor Necrosis Factors / Q000235:genetics
chemical_list: D008070:Lipopolysaccharides; D017981:Receptors, Neurotransmitter; D048069:Tumor Necrosis Factors; D002118:Calcium
keywords: Crassostrea gigas; circulating haemocyte; immune regulation; membrane receptor; neuroendocrine immunomodulatory axis