title: caspo: a toolbox for automated reasoning on the response of logical signaling networks families.
abstract: We introduce the caspo toolbox, a python package implementing a workflow for reasoning on logical networks families. Our software allows researchers to (i) a family of logical networks derived from a given topology and explaining the experimental response to various perturbations; (ii) all logical networks in a given family by their input-output behaviors; (iii) the response of the system to every possible perturbation based on the ensemble of predictions; (iv) new experimental perturbations to discriminate among a family of logical networks; and (v) a family of logical networks by finding all interventions strategies forcing a set of targets into a desired steady state.
  
  
  
  caspo is open-source software distributed under the GPLv3 license. Source code is publicly hosted at http://github.com/bioasp/caspo .
  
  
  
  anne.siegel@irisa.fr.
authors.affiliation: LBSI, Fundación Instituto Leloir (IIBBA-CONICET), Buenos Aires, C1405BWE, Argentina.
authors.forename: Santiago
authors.initials: S
authors.lastname: Videla
authors.affiliation: RWTH Aachen University, Faculty of Medicine, Joint Research Centre for Computational Biomedicine, Aachen D-52074, Germany.|European Molecular Biology Laboratory-European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton CB10 1SD, UK.
authors.forename: Julio
authors.initials: J
authors.lastname: Saez-Rodriguez
authors.affiliation: IRCCyN UMR CNRS 6597, École Centrale de Nantes, Nantes 44321, France.
authors.forename: Carito
authors.initials: C
authors.lastname: Guziolowski
authors.affiliation: CNRS, UMR 6074-IRISA, 35042 Rennes, France.|Dyliss project, INRIA, Campus de Beaulieu, Rennes 35000, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Siegel
mesh_terms: D022781:Hepatocytes / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D010750:Phosphoproteins; D015398:Signal Transduction; D012984:Software; D049490:Systems Biology / Q000379:methods*; D057188:Workflow
chemical_list: D010750:Phosphoproteins