title: The Photolyase/Cryptochrome Family of Proteins as DNA Repair Enzymes and Transcriptional Repressors.
abstract: Light is a very important environmental factor that governs many cellular responses in organisms. As a consequence, organisms possess different kinds of light-sensing photoreceptors to regulate their physiological variables and adapt to a given habitat. The cryptochrome/photolyase family (CPF) includes photoreceptors that perform different functions in different organisms. Photolyases repair ultraviolet-induced DNA damage by a process known as photoreactivation using photons absorbed from the blue end of the light spectrum. On the other hand, cryptochromes act as blue light circadian photoreceptors in plants and Drosophila to regulate growth and development. In mammals, cryptochromes have light-independent functions and are very important transcriptional regulators that act at the molecular level as negative transcriptional regulators of the circadian clock. In this review, we highlight current knowledge concerning the structural and functional relationships of CPF members.
authors.affiliation: Department of Chemical and Biological Engineering, Koc University, Sariyer, Istanbul, Turkey.|Department of Molecular Biology and Genetics, Koc University, Sariyer, Istanbul, Turkey.|Department of Computational Science and Engineering, Koc University, Sariyer, Istanbul, Turkey.
authors.forename: Ibrahim Halil
authors.initials: IH
authors.lastname: Kavakli
authors.affiliation: Department of Molecular Biology and Genetics, Koc University, Sariyer, Istanbul, Turkey.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Baris
authors.affiliation: Department of Computational Science and Engineering, Koc University, Sariyer, Istanbul, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Tardu
authors.affiliation: Department of Chemical and Biological Engineering, Koc University, Sariyer, Istanbul, Turkey.
authors.forename: Şeref
authors.initials: Ş
authors.lastname: Gül
authors.affiliation: Department of Chemical and Biological Engineering, Koc University, Sariyer, Istanbul, Turkey.
authors.forename: Haşimcan
authors.initials: H
authors.lastname: Öner
authors.affiliation: Department of Molecular Biology and Genetics, Koc University, Sariyer, Istanbul, Turkey.
authors.forename: Sibel
authors.initials: S
authors.lastname: Çal
authors.affiliation: Department of Chemical and Biological Engineering, Koc University, Sariyer, Istanbul, Turkey.
authors.forename: Selma
authors.initials: S
authors.lastname: Bulut
authors.affiliation: Department of Chemical and Biological Engineering, Koc University, Sariyer, Istanbul, Turkey.
authors.forename: Darya
authors.initials: D
authors.lastname: Yarparvar
authors.affiliation: Department of Molecular Biology and Genetics, Koc University, Sariyer, Istanbul, Turkey.
authors.forename: Çağlar
authors.initials: Ç
authors.lastname: Berkel
authors.affiliation: Department of Molecular Biology and Genetics, Koc University, Sariyer, Istanbul, Turkey.
authors.forename: Pınar
authors.initials: P
authors.lastname: Ustaoğlu
authors.affiliation: Department of Molecular Biology and Genetics, Istanbul Medeniyet University, Uskudar, Istanbul.
authors.forename: Cihan
authors.initials: C
authors.lastname: Aydın
mesh_terms: D000818:Animals; D017360:Arabidopsis / Q000378:metabolism; D029681:Arabidopsis Proteins / Q000378:metabolism; D002940:Circadian Rhythm; D056931:Cryptochromes / Q000378:metabolism*; D018360:Crystallography, X-Ray; D004260:DNA Repair; D004255:Deoxyribodipyrimidine Photo-Lyase / Q000737:chemistry / Q000378:metabolism*; D004330:Drosophila; D029721:Drosophila Proteins / Q000378:metabolism; D011487:Protein Conformation; D012097:Repressor Proteins / Q000378:metabolism*; D013329:Structure-Activity Relationship; D014158:Transcription, Genetic; D014466:Ultraviolet Rays
chemical_list: D029681:Arabidopsis Proteins; D056931:Cryptochromes; D029721:Drosophila Proteins; D012097:Repressor Proteins; D004255:Deoxyribodipyrimidine Photo-Lyase