title: Gd(III)-induced Supramolecular Hydrogelation with Enhanced Magnetic Resonance Performance for Enzyme Detection.
abstract: Here we report a supramolecular hydrogel based on Gd(III)-peptide complexes with dramatically enhanced magnetic resonance (MR) performance. The hydrogelations were formed by adding Gd(III) ion to the nanofiber dispersion of self-assembling peptides naphthalene-Gly-Phe-Phe-Tyr-Gly-Arg-Gly-Asp (Nap-GFFYGRGD) or naphthalene-Gly-Phe-Phe-Tyr-Gly-Arg-Gly-Glu (Nap-GFFYGRGE). We further showed that, by adjusting the molar ratio between Gd(III) and the corresponding peptide, the mechanical property of resulting gels could be fine-tuned. The longitudinal relaxivity (r1) of the Nap-GFFYGRGE-Gd(III) was 58.9 mM-1S-1, which to our knowledge is the highest value for such peptide-Gd(III) complexes so far. Such an enhancement of r1value could be applied for enzyme detection in aqueous solutions and cell lysates.
authors.affiliation: Department of Cardiology, Zhujiang Hospital of Southern Medical University, Guangzhou 510280, P. R. China.
authors.forename: Yongquan
authors.initials: Y
authors.lastname: Hua
authors.affiliation: School of Pharmaceutical Engineering &Life Science, Changzhou University, Changzhou 213164, P. R. China.|State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, and Collaborative Innovation Center of Chemical Science and Engineering, Tianjin 300071, P. R. China.
authors.forename: Guojuan
authors.initials: G
authors.lastname: Pu
authors.affiliation: Department of Cardiology, Zhujiang Hospital of Southern Medical University, Guangzhou 510280, P. R. China.
authors.forename: Caiwen
authors.initials: C
authors.lastname: Ou
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, and Collaborative Innovation Center of Chemical Science and Engineering, Tianjin 300071, P. R. China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, and Collaborative Innovation Center of Chemical Science and Engineering, Tianjin 300071, P. R. China.
authors.forename: Ling
authors.initials: L
authors.lastname: Wang
authors.affiliation: School of Pharmaceutical Engineering &Life Science, Changzhou University, Changzhou 213164, P. R. China.
authors.forename: Jiangtao
authors.initials: J
authors.lastname: Sun
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, and Collaborative Innovation Center of Chemical Science and Engineering, Tianjin 300071, P. R. China.
authors.forename: Zhimou
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Department of Cardiology, Zhujiang Hospital of Southern Medical University, Guangzhou 510280, P. R. China.
authors.forename: Minsheng
authors.initials: M
authors.lastname: Chen
mesh_terms: D004798:Enzymes / Q000032:analysis*; D005682:Gadolinium / Q000378:metabolism*; D020100:Hydrogels / Q000737:chemistry* / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D010455:Peptides / Q000378:metabolism*
chemical_list: D004798:Enzymes; D020100:Hydrogels; D010455:Peptides; D005682:Gadolinium