title: Expressions of CD44,CD47,and c-met in Ovarian Clear Cell Carcinoma and Their Clinical Significance.
abstract: Objective To investigate the expressions of CD44,CD47,and c-met in ovarian clear cell carcinoma (OCCC) tissue and their correlations with clinical variables and prognosis. Methods Immunohistochemical method was used to investigate the expressions of CD44,CD47,and c-met in tissues from 86 OCCC patients and the relationships of their expressions with the clinicopathological factors of OCCC were analyzed. Results The expressions of CD44,CD47,and c-met were significantly high in OCCC tissues (90.7%,91.9%,and 94.2%,respectively). The strong positive expressions of CD44 and CD47 were significantly correlated with advanced International Federation of Gynecology and Obstetrics stages,chemotherapeutic resistance,and poor prognosis (all P<0.05),the strong positive expression of c-met was significantly correlated with chemotherapeutic resistance and poor prognosis (all P<0.05),whereas there was no correlation between the strong positive expressions of CD44,CD47,and c-met and the lymphatic node metastasis. COX survival analysis revealed that advanced International Federation of Gynecology and Obstetrics stages and high expressions of CD44,CD47 and c-met were independent risk factors for poor prognosis (P<0.05). There was a positive correlation between CD44 (or CD47) and c-met and between CD44 and CD47 (the Spearman correlation coefficient rswas 0.783,0.776,and 0.835,respectively,all P<0.01). Conclusions The expressions of CD44,CD47,and c-met increase in OCCC tissues and are correlated with each other. High expressions of CD44,CD47,and c-met are independent factors for poor prognosis.
authors.affiliation: Department of Obstetrics and Gynecology,Shengjing Hospital Affiliated to China Medical University,Shenyang 110004,China.
authors.forename: Hui-Min
authors.initials: HM
authors.lastname: Wang
authors.affiliation: Department of Obstetrics and Gynecology,Shengjing Hospital Affiliated to China Medical University,Shenyang 110004,China.
authors.forename: Ming-Zi
authors.initials: MZ
authors.lastname: Tan
authors.affiliation: Department of Obstetrics and Gynecology,Shengjing Hospital Affiliated to China Medical University,Shenyang 110004,China; Department of Obstetrics and Gynecology,Dalian Maternity Hospital,Dalian,Liaoning 116033,China.
authors.forename: Song
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Obstetrics and Gynecology,Shengjing Hospital Affiliated to China Medical University,Shenyang 110004,China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Obstetrics and Gynecology,Shengjing Hospital Affiliated to China Medical University,Shenyang 110004,China.
authors.forename: Jian
authors.initials: J
authors.lastname: Gao
authors.affiliation: Department of Obstetrics and Gynecology,Shengjing Hospital Affiliated to China Medical University,Shenyang 110004,China.
authors.forename: Dan-Ye
authors.initials: DY
authors.lastname: Zhang
authors.affiliation: Department of Obstetrics and Gynecology,Shengjing Hospital Affiliated to China Medical University,Shenyang 110004,China.
authors.forename: Ying-Ying
authors.initials: YY
authors.lastname: Hao
authors.affiliation: Department of Obstetrics and Gynecology,Shengjing Hospital Affiliated to China Medical University,Shenyang 110004,China.
authors.forename: Song
authors.initials: S
authors.lastname: Gao
authors.affiliation: Department of Obstetrics and Gynecology,Shengjing Hospital Affiliated to China Medical University,Shenyang 110004,China.
authors.forename: Juan-Juan
authors.initials: JJ
authors.lastname: Liu
authors.affiliation: Department of Obstetrics and Gynecology,Shengjing Hospital Affiliated to China Medical University,Shenyang 110004,China.
authors.forename: Bei
authors.initials: B
authors.lastname: Lin
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000378:metabolism*; D051928:CD47 Antigen / Q000378:metabolism*; D005260:Female; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism*; D008207:Lymphatic Metastasis; D010051:Ovarian Neoplasms / Q000378:metabolism*; D011379:Prognosis; D019859:Proto-Oncogene Proteins c-met / Q000378:metabolism*; D016019:Survival Analysis
chemical_list: C497483:CD44 protein, human; D051928:CD47 Antigen; C497894:CD47 protein, human; D018960:Hyaluronan Receptors; C491743:MET protein, human; D019859:Proto-Oncogene Proteins c-met