title: Mutated Chromatin Regulatory Factors as Tumor Drivers in Cancer.
abstract: Genes encoding proteins that regulate chromatin structure and DNA modifications [i.e., chromatin regulatory factors (CRF)] and genes encoding histone proteins harbor recurrent mutations in most human cancers. These mutations lead to modifications in tumor chromatin and DNA structure and an altered epigenetic state that contribute to tumorigenesis. Mutated CRFs have now been identified in most types of cancer and are increasingly regarded as novel therapeutic targets. In this review, we discuss DNA alterations in CRFs and how these influence tumor chromatin structure and function, which in turn leads to tumorigenesis. We also discuss the clinical implications and review concepts of targeted treatments for these mutations. Continued research on CRF mutations will be critical for our future understanding of cancer biology and the development and implementation of novel cancer therapies. Cancer Res; 77(2); 227-33. ©2017 AACR.
authors.affiliation: Department of Pediatrics, Division of Pediatric Hematology-Oncology, University of Michigan Medical School, Ann Arbor, Michigan.|Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, Michigan.
authors.forename: Carl
authors.initials: C
authors.lastname: Koschmann
authors.affiliation: Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, Michigan.|Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan.
authors.forename: Felipe J
authors.initials: FJ
authors.lastname: Nunez
authors.affiliation: Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan.
authors.forename: Flor
authors.initials: F
authors.lastname: Mendez
authors.affiliation: Department of Pathology, Johns Hopkins University, Baltimore, Maryland.
authors.forename: Jacqueline A
authors.initials: JA
authors.lastname: Brosnan-Cashman
authors.affiliation: Department of Pathology, Johns Hopkins University, Baltimore, Maryland.|Department of Urology, Johns Hopkins University, Baltimore, Michigan.
authors.forename: Alan K
authors.initials: AK
authors.lastname: Meeker
authors.affiliation: Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, Michigan.|Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan.
authors.forename: Pedro R
authors.initials: PR
authors.lastname: Lowenstein
authors.affiliation: Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, Michigan. mariacas@med.umich.edu.|Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan.
authors.forename: Maria G
authors.initials: MG
authors.lastname: Castro
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D002843:Chromatin / Q000235:genetics*; D042002:Chromatin Assembly and Disassembly / Q000235:genetics; D044127:Epigenesis, Genetic / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology*; D006657:Histones; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: D002843:Chromatin; D006657:Histones