title: Magnetoencephalography and New Imaging Modalities in Epilepsy.
abstract: The success of epilepsy surgery is highly dependent on correctly identifying the entire epileptogenic region. Current state-of-the-art for localizing the extent of surgically amenable areas involves combining high resolution three-dimensional magnetic resonance imaging (MRI) with electroencephalography (EEG) and magnetoencephalography (MEG) source modeling of interictal epileptiform activity. Coupling these techniques with newer quantitative structural MRI techniques, such as cortical thickness measurements, however, may improve the extent to which the abnormal epileptogenic region can be visualized. In this review we assess the utility of EEG, MEG and quantitative structural MRI methods for the evaluation of patients with epilepsy and introduce a novel method for the co-localization of a structural MRI measurement to MEG and EEG source modeling. When combined, these techniques may better identify the extent of abnormal structural and functional areas in patients with medically intractable epilepsy.
authors.affiliation: Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
authors.forename: Jessica
authors.initials: J
authors.lastname: Falco-Walter
authors.affiliation: Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
authors.forename: Christian
authors.initials: C
authors.lastname: Owen
authors.affiliation: Rush Medical College, Chicago, IL, USA.
authors.forename: Mishu
authors.initials: M
authors.lastname: Sharma
authors.affiliation: Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Reggi
authors.affiliation: Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
authors.forename: Mandy
authors.initials: M
authors.lastname: Yu
authors.affiliation: Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA. tstoub@rush.edu.
authors.forename: Travis R
authors.initials: TR
authors.lastname: Stoub
authors.affiliation: Department of Neurology, Barrow Neurological Institute, Phoenix, AZ, USA.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Stein
mesh_terms: D002540:Cerebral Cortex / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology; D004569:Electroencephalography; D004827:Epilepsy / Q000000981:diagnostic imaging* / Q000628:therapy*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging; D015225:Magnetoencephalography; D065703:Malformations of Cortical Development, Group I / Q000000981:diagnostic imaging / Q000628:therapy; D016896:Treatment Outcome
keywords: EEG; Epilepsy; Focal cortical dysplasia; Imaging; MEG; MRI