title: Rhodium-catalyzed enantioselective hydrogenation of α-amino acrylonitriles: an efficient approach to synthesizing chiral α-amino nitriles.
abstract: An efficient rhodium-catalyzed asymmetric hydrogenation of α-amino acrylonitriles has been developed, affording α-acylamino nitriles with high yields and excellent enantioselectivities (up to 99% yield and >99% ee). This novel methodology provides an efficient and concise synthetic route to chiral α-amino nitriles, which are versatile intermediates in organic synthesis.
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, P. R. China. huilv@whu.edu.cn.
authors.forename: Xiuxiu
authors.initials: X
authors.lastname: Li
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, P. R. China. huilv@whu.edu.cn.
authors.forename: Cai
authors.initials: C
authors.lastname: You
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, P. R. China. huilv@whu.edu.cn.
authors.forename: Yusheng
authors.initials: Y
authors.lastname: Yang
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, P. R. China. huilv@whu.edu.cn.
authors.forename: Fangyuan
authors.initials: F
authors.lastname: Wang
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, P. R. China. huilv@whu.edu.cn.
authors.forename: Shuailong
authors.initials: S
authors.lastname: Li
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, P. R. China. huilv@whu.edu.cn.
authors.forename: Hui
authors.initials: H
authors.lastname: Lv
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, P. R. China. huilv@whu.edu.cn and Department of Chemistry, South University of Science and Technology of China, Shenzhen, Guangdong 518055, P. R. China. zhangxm@sustc.edu.cn.
authors.forename: Xumu
authors.identifier: http://orcid.org/0000-0003-1378-1945
authors.initials: X
authors.lastname: Zhang