title: Elevated spondin-2 expression correlates with progression and prognosis in gastric cancer.
abstract: The spondin-2 correlated with tumor progression in many malignancies. However, the role of spondin-2 in gastric cancer has not been thoroughly elucidated. Spondin-2 and matrix metallopeptidase 9 (MMP-9) expression was detected by immunohistochemistry in 174 gastric carcinoma tissues. The relationship between the expression of spondin-2 and MMP-9, clinicopathological/prognostic value in gastric cancer was examined. Spondin-2 was significantly higher in gastric cancer than that in adjacent non-tumorous tissues. Spondin-2 overexpression was significantly associated with well differentiation, depth of invasion, lymph node metastasis, and advanced TNM stages. The expression levels of spondin-2 were increasing in both prominent serosal invasion group and lymph node metastasis group. In addition, spondin-2 was positively correlated with MMP-9 among 174 gastric cancer samples. In univariate and multivariate analyses, spondin-2 was an independent prognostic factor for both recurrence-free survival (RFS) and overall survival (OS). Moreover, spondin-2 overexpression was associated with poor prognosis in patients with gastric cancer in different risk groups. In conclusion, Spondin-2 overexpression contributes to tumor aggressiveness and prognosis, and could be a promising target for prognostic prediction in gastric cancer patients.
authors.affiliation: Department of Medical Oncology, Cancer Center of Guangzhou Medical University, Guangzhou, 510095, Guangdong, China.
authors.forename: Chuan
authors.initials: C
authors.lastname: Jin
authors.affiliation: Department of Medical Oncology, Cancer Center of Guangzhou Medical University, Guangzhou, 510095, Guangdong, China.
authors.forename: Jin-Rong
authors.initials: JR
authors.lastname: Lin
authors.affiliation: Department of Medical Oncology, Cancer Center of Guangzhou Medical University, Guangzhou, 510095, Guangdong, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Ma
authors.affiliation: Department of Medical Oncology, Cancer Center of Guangzhou Medical University, Guangzhou, 510095, Guangdong, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Song
authors.affiliation: Department of Medical Oncology, Cancer Center of Guangzhou Medical University, Guangzhou, 510095, Guangdong, China.
authors.forename: Yan-Xia
authors.initials: YX
authors.lastname: Shi
authors.affiliation: Department of Medical Oncology, Cancer Center of Guangzhou Medical University, Guangzhou, 510095, Guangdong, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Jiang
authors.affiliation: Department of Medical Oncology, Cancer Center of Guangzhou Medical University, Guangzhou, 510095, Guangdong, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Dong
authors.affiliation: Department of Medical Oncology, Cancer Center of Guangzhou Medical University, Guangzhou, 510095, Guangdong, China.
authors.forename: Xiao-Shan
authors.initials: XS
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D002454:Cell Differentiation; D018450:Disease Progression; D018572:Disease-Free Survival; D016326:Extracellular Matrix Proteins / Q000032:analysis*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000032:analysis; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D009363:Neoplasm Proteins / Q000032:analysis*; D009367:Neoplasm Staging; D016016:Proportional Hazards Models; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000737:chemistry* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D013997:Time Factors; D016896:Treatment Outcome; D047368:Tumor Burden; D015854:Up-Regulation; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D016326:Extracellular Matrix Proteins; D009363:Neoplasm Proteins; C122166:SPON2 protein, human; C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9
keywords: aggressiveness; gastric cancer; prognosis; spondin-2