title: Synthesis of bioactive and fluorescent pyridine-triazole-coumarin peptidomimetics through sequential click-multicomponent reactions.
abstract: An easy synthetic protocol for the peptide randomization of 3,5-dicyano pyridine derivatives by linking the pyridine core with a coumarin chromophore spaced by a linker triazole via copper (I) catalyzed [3+2] azide-alkyne cycloaddition (CuAAC) is described. The new peptidomimetics thus obtained are extended rule of 5 (eRo5) molecules suitable for the development of therapeutic agents for undruggable targets. The structural and photophysical properties of the molecules are also promising for the development of potential bio imaging agents based on these molecules.
authors.affiliation: Department of Chemistry, University of Calicut, Malappuram 673635, Kerala, India.
authors.forename: T V
authors.initials: TV
authors.lastname: Soumya
authors.affiliation: Department of Chemistry, University of Calicut, Malappuram 673635, Kerala, India.
authors.forename: C
authors.initials: C
authors.lastname: Muhammed Ajmal
authors.affiliation: Department of Chemistry, University of Calicut, Malappuram 673635, Kerala, India. Electronic address: bahulayan@yahoo.com.
authors.forename: D
authors.initials: D
authors.lastname: Bahulayan
mesh_terms: D000480:Alkynes / Q000737:chemistry; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001386:Azides / Q000737:chemistry; D002384:Catalysis; D002470:Cell Survival / Q000187:drug effects; D003300:Copper / Q000737:chemistry; D003374:Coumarins / Q000737:chemistry*; D061565:Cycloaddition Reaction; D006801:Humans; D061986:MCF-7 Cells; D008856:Microscopy, Fluorescence; D057786:Peptidomimetics; D011725:Pyridines / Q000737:chemistry*; D011789:Quantum Theory; D014230:Triazoles / Q000737:chemistry*
chemical_list: D000480:Alkynes; D000970:Antineoplastic Agents; D001386:Azides; D003374:Coumarins; D057786:Peptidomimetics; D011725:Pyridines; D014230:Triazoles; D003300:Copper; C030123:coumarin; C023666:pyridine
keywords: 1,2,3-Triazole; Fluorescence; MCR-click; Peptidomimetics; eRo5