title: In situ degradation of antibiotic residues in medical intravenous infusion bottles using high energy electron beam irradiation.
abstract: This study reported an immediate approach for the degradation of three antibiotic (amoxicillin, ofloxacin, and cefradine) residues in medical intravenous infusion bottles (MIIBs) using high energy electron beam (HEEB) irradiation. The effects of irradiation doses, initial concentrations, initial pH, and scavengers of active radicals on the degradation of three antibiotic residues (ARs) were investigated, and the results displayed that 97.02%, 97.61% and 96.87% of amoxicillin, ofloxacin, and cefradine residues could be degraded in situ through HEEB irradiation respectively. Fourier transform infrared spectroscopy (FTIR) and high performance liquid chromatography-mass spectrometry (HPLC-MS) analysis demonstrated that ARs were mainly decomposed into inorganic ions and alkanes. Typically, the detailed degradation mechanism of ARs was also investigated, and the dominant active particle inducing the degradation of antibiotics during the HEEB irradiation process was demonstrated to be hydroxyl radical.
authors.affiliation: Key Laboratory of Ion Beam Bioengineering, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, People's Republic of China.|University of Science and Technology of China, Hefei 230026, People's Republic of China.
authors.forename: Min
authors.initials: M
authors.lastname: Wang
authors.affiliation: School of Life Sciences, Anhui Agricultural University, Hefei 230036, People's Republic of China.
authors.forename: Lele
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Ion Beam Bioengineering, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, People's Republic of China.|University of Science and Technology of China, Hefei 230026, People's Republic of China.
authors.forename: Guilong
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Anhui Jianghuai Automobile Co., Ltd, Hefei 230022, People's Republic of China.
authors.forename: Tao
authors.initials: T
authors.lastname: Pang
authors.affiliation: School of Life Sciences, Anhui Agricultural University, Hefei 230036, People's Republic of China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Ion Beam Bioengineering, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, People's Republic of China.|University of Science and Technology of China, Hefei 230026, People's Republic of China.|Key Laboratory of Environmental Toxicology and Pollution Control Technology of Anhui Province, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, People's Republic of China.
authors.forename: Dongqing
authors.initials: D
authors.lastname: Cai
authors.affiliation: Key Laboratory of Ion Beam Bioengineering, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, People's Republic of China.|University of Science and Technology of China, Hefei 230026, People's Republic of China.|Key Laboratory of Environmental Toxicology and Pollution Control Technology of Anhui Province, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, People's Republic of China.
authors.forename: Zhengyan
authors.initials: Z
authors.lastname: Wu
mesh_terms: D000658:Amoxicillin / Q000032:analysis / Q000528:radiation effects; D000900:Anti-Bacterial Agents / Q000032:analysis* / Q000737:chemistry / Q000528:radiation effects; D055984:Cathode Ray Tube; D002515:Cephradine / Q000032:analysis / Q000528:radiation effects; D002851:Chromatography, High Pressure Liquid; D006863:Hydrogen-Ion Concentration; D013058:Mass Spectrometry; D015242:Ofloxacin / Q000032:analysis / Q000528:radiation effects; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000900:Anti-Bacterial Agents; D000658:Amoxicillin; D015242:Ofloxacin; D002515:Cephradine