title: Predictors of response to viscosupplementation in patients with hip osteoarthritis: results of a prospective, observational, multicentre, open-label, pilot study.
abstract: To identify predictive factors of response to viscosupplementation (VS) in patients with hip osteoarthritis (HOA).
  
  
  
  Prospective, multicentre, open-label trial, achieved in daily practice conditions. Patients with HOA were treated with a single intra-articular injection of a cross-linked hyaluronic acid combined with mannitol (HAnox-M-XL), using imaging guidance. WOMAC pain and function scores and patient global assessment (PGA) were assessed at baseline and day 90. Improvement, satisfaction and efficacy were self-assessed at day 90. Hip radiographs at baseline were scored using Kellgren-Lawrence grade and Osteoarthritis Research Society International (OARSI) score. Associations between clinical and radiological features and response to VS (pain improvement > 50% at day 90) were assessed in univariate analysis, and then using logistic regression, adjusted for confounding factors.
  
  
  
  The intent-to-treat (ITT) population included 97 patients (57 females, mean age 63). Ninety completed the follow-up and 80 had full clinical and radiological data. Response to VS was achieved in 47.8% of patients. In univariate analysis, the only clinical outcome statistically and negatively related to response was PGA at baseline (p = 0.047). Radiologically, response to VS was negatively correlated with joint space narrowing (JSN) score (JSN < 2 vs. JSN ≥ 2, p = 0.01) and was related to the patterns of femoral head migration (p = 0.008). In multivariate analysis, only JSN grade (p = 0.03) remained significantly related to a poor response.
  
  
  
  This pilot study, which needs further confirmation by larger scale trials, suggests that radiological features might be of importance for the decision of VS in patients with HOA.
  
  
  
  ID RCB N°2013-A00165-40. Registered 31 January 2013.
authors.affiliation: Department of rheumatology, AP-HP Henri Mondor Hospital, 51 avenue du Maréchal de Lattre de Tassigny, Créteil, 94000, France. florent.eymard@aphp.fr.
authors.forename: Florent
authors.initials: F
authors.lastname: Eymard
authors.affiliation: Clinique Saint Odilon, Moulins, 03000, France.
authors.forename: Bernard
authors.initials: B
authors.lastname: Maillet
authors.affiliation: Department of rheumatology, AP-HP Lariboisière Hospital, Paris, 75010, France.
authors.forename: Henri
authors.initials: H
authors.lastname: Lellouche
authors.affiliation: Pole A, Nevers Hospital, Nevers, 58000, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Mellac-Ducamp
authors.affiliation: Department of rheumatology, Princesse Grace Hospital, Monaco, 98000, Monaco.
authors.forename: Olivier
authors.initials: O
authors.lastname: Brocq
authors.affiliation: Department of rheumatology and IMoPA (Ingénierie Moléculaire et Physiopathologie Articulaires), Brabois University Hospital, Vandoeuvre-les-Nancy, 54511, France.
authors.forename: Damien
authors.initials: D
authors.lastname: Loeuille
authors.affiliation: Department of rheumatology, AP-HP Henri Mondor Hospital, 51 avenue du Maréchal de Lattre de Tassigny, Créteil, 94000, France.
authors.forename: Xavier
authors.initials: X
authors.lastname: Chevalier
authors.affiliation: Department of rheumatology, Nord Franche Comté Hospital, Belfort, 90000, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: Conrozier
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D015207:Osteoarthritis, Hip / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000453:epidemiology; D010147:Pain Measurement / Q000187:drug effects* / Q000379:methods*; D010865:Pilot Projects; D011237:Predictive Value of Tests; D011446:Prospective Studies; D016896:Treatment Outcome; D055676:Viscosupplementation / Q000379:methods*
chemical_list: D006820:Hyaluronic Acid
keywords: Hip OA; Joint space narrowing; Predictive factors; Viscosupplementation