title: A comparison of the metabolic complications and hospital course of severe anorexia nervosa by binge-purge and restricting subtypes.
abstract: This study examines adult patients with severe, life-threatening anorexia nervosa who were admitted to an inpatient, medical stabilization unit between October 1, 2008 and December 31, 2014. Specifically, the study compares anorexia nervosa, binge purge subtype (AN-BP) and anorexia nervosa, restricting subtype (AN-R) on admission measures, hospital course, and outcomes. Of the 232 patients, 46% (N = 108) had AN-BP. Patients with AN-R manifested a higher frequency of underweight-mediated medical complications, including bone marrow dysfunction, hepatic dysfunction, and hypoglycemia. Understanding the pathophysiologic differences between severe AN-R and AN-BP is essential to understanding the abnormalities seen on clinical presentation, guiding appropriate clinical treatment, and predicting medical complications during refeeding.
authors.affiliation: a Department of Medicine , University of Colorado , Denver , Colorado , USA.|b ACUTE Center for Eating Disorders at Denver Health , Denver , Colorado , USA.|c Department of Psychiatry , University of Colorado , Denver , Colorado , USA.
authors.forename: Melanie
authors.initials: M
authors.lastname: Rylander
authors.affiliation: d Department of Biostatistics and Informatics, Colorado School of Public Health , University of Colorado , Denver , Colorado , USA.
authors.forename: John T
authors.initials: JT
authors.lastname: Brinton
authors.affiliation: d Department of Biostatistics and Informatics, Colorado School of Public Health , University of Colorado , Denver , Colorado , USA.|e Department of Patient Safety and Quality , Denver Health , Denver , Colorado , USA.
authors.forename: Allison L
authors.initials: AL
authors.lastname: Sabel
authors.affiliation: a Department of Medicine , University of Colorado , Denver , Colorado , USA.|b ACUTE Center for Eating Disorders at Denver Health , Denver , Colorado , USA.|f Eating Recovery Center , Denver , Colorado , USA.
authors.forename: Philip S
authors.initials: PS
authors.lastname: Mehler
authors.affiliation: g Gaudiani Clinic , Denver , Colorado , USA.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Gaudiani
mesh_terms: D000328:Adult; D000856:Anorexia Nervosa / Q000097:blood* / Q000145:classification / Q000503:physiopathology* / Q000628:therapy; D056912:Binge-Eating Disorder / Q000097:blood* / Q000145:classification / Q000503:physiopathology* / Q000628:therapy; D018450:Disease Progression; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D055815:Young Adult