title: High expression of TRIM11 correlates with poor prognosis in patients with hepatocellular carcinoma.
abstract: BACKGROUND
  Tripartite Motif Containing 11 (TRIM11), a member of TRIM proteins is overexpressed in gliomas and lung cancer. However, the role of TRIM11 in hepatocellular carcinoma (HCC) is unknown.
  
  
  METHODS
  Herein, we aimed to investigate the expression and clinical significance role of TRIM11 in HCC.
  
  
  RESULTS
  In this study, our data showed significant higher TRIM11 in HCC tissues (n=117) than in the matched non-tumor liver (NTL) tissues (P<0.01). In consistent with above data, we also found TRIM11 protein expression was significantly increased compared with the matched NTL (P<0.01) by immunohistochemistry analysis. Additionally, our results showed that TRIM11 protein expression in HCC tissues was significantly associated with pathological grade (P<0.01), tumor postoperative metastasis (P=0.031), recurrence (P=0.022), and serum a-fetoprotein (AFP) (P<0.01). Moreover, patients' survival was negatively correlated with TRIM11 protein expression. Furthermore, we found that TRIM11 protein was an independent prognostic factor for disease-free (P<0.01) and overall survival (P<0.01) in HCC patients.
  
  
  CONCLUSIONS
  Our data showed that TRIM11 expression was significantly elevated in HCC tissues. The overexpression of TRIM11 is closely associated with HCC progression and poor survival of the patients, indicating TRIM11 is a potential therapeutic target for HCC patients.
authors.affiliation: Anhui Medical University, No. 81 Meishan Road, Hefei 230032, China; Anhui Provincial Hospital, No. 17 Lujiang Road, Hefei 230001, China; Department of General Surgery, Hefei Second People's Hospital, No. 246 Heping Road, Hefei 230011, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of General Surgery, Hefei Second People's Hospital, No. 246 Heping Road, Hefei 230011, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of General Surgery, Hefei Second People's Hospital, No. 246 Heping Road, Hefei 230011, China.
authors.forename: Xiaoxing
authors.initials: X
authors.lastname: Qian
authors.affiliation: Department of Hepatic Surgery, Anhui Provincial Hospital, No. 17 Lujiang Road, Hefei 230001, China.
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Ge
authors.affiliation: Anhui Medical University, No. 81 Meishan Road, Hefei 230032, China; Department of Hepatic Surgery, Anhui Provincial Hospital, No. 17 Lujiang Road, Hefei 230001, China. Electronic address: xuegl2006@126.com.
authors.forename: Geliang
authors.initials: G
authors.lastname: Xu
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000737:chemistry* / Q000378:metabolism* / Q000473:pathology; D018572:Disease-Free Survival; D005260:Female; D015870:Gene Expression; D006801:Humans; D007150:Immunohistochemistry; D008099:Liver / Q000737:chemistry / Q000473:pathology; D008113:Liver Neoplasms / Q000737:chemistry* / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000737:chemistry; D011379:Prognosis; D060888:Real-Time Polymerase Chain Reaction; D015996:Survival Rate; D000070584:Tripartite Motif Proteins / Q000032:analysis / Q000235:genetics* / Q000502:physiology; D044767:Ubiquitin-Protein Ligases / Q000032:analysis / Q000235:genetics* / Q000502:physiology; D000509:alpha-Fetoproteins
chemical_list: D000070584:Tripartite Motif Proteins; D000509:alpha-Fetoproteins; C510874:TRIM11 protein, human; D044767:Ubiquitin-Protein Ligases