title: Retinoic acid takes effector T cells to the gallows: P2X7, the molecular hangman.
abstract: Effector T-cell contraction is one of the primary means by which immune homeostasis in the peripheral tissues is reestablished following an inflammatory response. In this issue of Mucosal Immunology, Hashimoto-Hill et al.1show that retinoic acid (RA) transcriptionally upregulates P2X7 primarily in effector T cells of the intestine sensitizing them to NAD-induced cell death (NICD); thus, demonstrating a previously unrecognized role of RA in effector T-cell contraction.
authors.affiliation: Department of Medicine, Solna, Immunology and Allergy Unit, Karolinska Institutet and University Hospital, Stockholm, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Das
authors.affiliation: Department of Medicine, Solna, Immunology and Allergy Unit, Karolinska Institutet and University Hospital, Stockholm, Sweden.
authors.forename: E J
authors.initials: EJ
authors.lastname: Villablanca
mesh_terms: D011983:Receptors, Purinergic; D013601:T-Lymphocytes; D014212:Tretinoin
chemical_list: D011983:Receptors, Purinergic; D014212:Tretinoin