title: Circulating T lymphocyte subsets, cytokines, and immune checkpoint inhibitors in patients with bipolar II or major depression: a preliminary study.
abstract: This study aimed to investigate the less known activation pattern of T lymphocyte populations and immune checkpoint inhibitors on immunocytes in patients with bipolar II disorder depression (BD) or major depression (MD). A total of 23 patients with BD, 22 patients with MD, and 20 healthy controls (HCs) were recruited. The blood cell count of T lymphocyte subsets and the plasma level of cytokines (IL-2, IL-4, IL-6, IL-10, TNF-α, and IFN-γ) were selectively investigated. The expression of T-cell immunoglobulin and mucin-domain containing-3 (TIM-3), programmed cell death protein 1 (PD-1) and its ligands, PD-L1 and PD-L2, on T lymphocytes and monocytes, was detected. In results, blood proportion of cytotoxic T cells significantly decreased in BD patients than in either MD patients or HCs. The plasma level of IL-6 increased in patients with BD and MD. The expression of TIM-3 on cytotoxic T cells significantly increased, whereas the expression of PD-L2 on monocytes significantly decreased in patients with BD than in HCs. These findings extended our knowledge of the immune dysfunction in patients with affective disorders.
authors.affiliation: Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory of Diagnostic and Treatment of Infectious Diseases, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wu
authors.affiliation: Zhejiang University School of Medicine, Hangzhou 310058, China.|Mental Health Center, Zhejiang Xiaoshan Hospital, Hangzhou 311200, China.
authors.forename: Ya-Li
authors.initials: YL
authors.lastname: Zheng
authors.affiliation: Zhejiang University School of Medicine, Hangzhou 310058, China.|Department of Psychiatry, Shaoxing Seventh Hospital, Shaoxing 312000, China.
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Tian
authors.affiliation: Department of Psychiatry, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.|The Key Laboratory of Mental Disorder Management in Zhejiang Province, Hangzhou 310003, China.
authors.forename: Jian-Bo
authors.initials: JB
authors.lastname: Lai
authors.affiliation: Department of Psychiatry, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.|The Key Laboratory of Mental Disorder Management in Zhejiang Province, Hangzhou 310003, China.
authors.forename: Chan-Chan
authors.initials: CC
authors.lastname: Hu
authors.affiliation: Zhejiang University School of Medicine, Hangzhou 310058, China.|Mental Health Center, Zhejiang Xiaoshan Hospital, Hangzhou 311200, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Department of Psychiatry, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.|The Key Laboratory of Mental Disorder Management in Zhejiang Province, Hangzhou 310003, China.
authors.forename: Jing-Kai
authors.initials: JK
authors.lastname: Chen
authors.affiliation: Department of Psychiatry, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.|The Key Laboratory of Mental Disorder Management in Zhejiang Province, Hangzhou 310003, China.
authors.forename: Jian-Bo
authors.initials: JB
authors.lastname: Hu
authors.affiliation: Department of Psychiatry, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.|The Key Laboratory of Mental Disorder Management in Zhejiang Province, Hangzhou 310003, China.
authors.forename: Man-Li
authors.initials: ML
authors.lastname: Huang
authors.affiliation: Department of Psychiatry, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.|The Key Laboratory of Mental Disorder Management in Zhejiang Province, Hangzhou 310003, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Wei
authors.affiliation: Department of Psychiatry, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.|The Key Laboratory of Mental Disorder Management in Zhejiang Province, Hangzhou 310003, China.
authors.forename: Wei-Juan
authors.initials: WJ
authors.lastname: Xu
authors.affiliation: Department of Psychiatry, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.|The Key Laboratory of Mental Disorder Management in Zhejiang Province, Hangzhou 310003, China.
authors.forename: Wei-Hua
authors.initials: WH
authors.lastname: Zhou
authors.affiliation: Department of Psychiatry, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.|The Key Laboratory of Mental Disorder Management in Zhejiang Province, Hangzhou 310003, China.
authors.forename: Shao-Jia
authors.initials: SJ
authors.lastname: Lu
authors.affiliation: Department of Psychiatry, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.|The Key Laboratory of Mental Disorder Management in Zhejiang Province, Hangzhou 310003, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Lu
authors.affiliation: Department of Psychiatry, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.|The Key Laboratory of Mental Disorder Management in Zhejiang Province, Hangzhou 310003, China.
authors.forename: Hong-Li
authors.initials: HL
authors.lastname: Qi
authors.affiliation: Department of Psychiatry, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.|The Key Laboratory of Mental Disorder Management in Zhejiang Province, Hangzhou 310003, China.
authors.forename: Dan-Dan
authors.initials: DD
authors.lastname: Wang
authors.affiliation: Department of Psychiatry, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.|The Key Laboratory of Mental Disorder Management in Zhejiang Province, Hangzhou 310003, China.
authors.forename: Xiao-Yi
authors.initials: XY
authors.lastname: Zhou
authors.affiliation: Department of Psychiatry, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.|The Key Laboratory of Mental Disorder Management in Zhejiang Province, Hangzhou 310003, China.
authors.forename: Jin-Feng
authors.initials: JF
authors.lastname: Duan
authors.affiliation: Department of Psychiatry, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.|The Key Laboratory of Mental Disorder Management in Zhejiang Province, Hangzhou 310003, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Psychiatry, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.|The Key Laboratory of Mental Disorder Management in Zhejiang Province, Hangzhou 310003, China.
authors.forename: Shao-Hua
authors.initials: SH
authors.lastname: Hu
mesh_terms: D000328:Adult; D060890:B7-H1 Antigen / Q000378:metabolism; D001714:Bipolar Disorder / Q000097:blood* / Q000276:immunology*; D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood*; D003710:Demography; D003865:Major Depressive Disorder / Q000097:blood* / Q000276:immunology*; D005260:Female; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology; D008297:Male; D016176:T-Lymphocyte Subsets / Q000276:immunology*
chemical_list: D060890:B7-H1 Antigen; C423236:CD274 protein, human; D016207:Cytokines