title: Hollow boron nitride nanospheres as boron reservoir for prostate cancer treatment.
abstract: High global incidence of prostate cancer has led to a focus on prevention and treatment strategies to reduce the impact of this disease in public health. Boron compounds are increasingly recognized as preventative and chemotherapeutic agents. However, systemic administration of soluble boron compounds is hampered by their short half-life and low effectiveness. Here we report on hollow boron nitride (BN) spheres with controlled crystallinity and boron release that decrease cell viability and increase prostate cancer cell apoptosis. In vivo experiments on subcutaneous tumour mouse models treated with BN spheres demonstrated significant suppression of tumour growth. An orthotopic tumour growth model was also utilized and further confirmed the in vivo anti-cancer efficacy of BN spheres. Moreover, the administration of hollow BN spheres with paclitaxel leads to synergetic effects in the suppression of tumour growth. The work demonstrates that hollow BN spheres may function as a new agent for prostate cancer treatment.
authors.affiliation: World Premier International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS), Namiki 1-1, Tsukuba, Ibaraki 305-0044, Japan.
authors.forename: Xia
authors.initials: X
authors.lastname: Li
authors.affiliation: Health Research Institute, Department of Life Science and Biotechnology, National Institute of Advanced Industrial Science and Technology (AIST), Central 6, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan.
authors.forename: Xiupeng
authors.initials: X
authors.lastname: Wang
authors.affiliation: World Premier International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS), Namiki 1-1, Tsukuba, Ibaraki 305-0044, Japan.|School of Materials Science and Engineering, Hebei Key Laboratory of Boron Nitride Micro and Nano Materials, Hebei University of Technology, Tianjin 300130, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Nanotechnology Innovation Station, National Institute for Materials Science (NIMS), 1-2-1 Sengen, Tsukuba, 305-0047, Japan.
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Hanagata
authors.affiliation: World Premier International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS), Namiki 1-1, Tsukuba, Ibaraki 305-0044, Japan.
authors.forename: Xuebin
authors.initials: X
authors.lastname: Wang
authors.affiliation: World Premier International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS), Namiki 1-1, Tsukuba, Ibaraki 305-0044, Japan.
authors.forename: Qunhong
authors.initials: Q
authors.lastname: Weng
authors.affiliation: Health Research Institute, Department of Life Science and Biotechnology, National Institute of Advanced Industrial Science and Technology (AIST), Central 6, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan.
authors.forename: Atsuo
authors.initials: A
authors.lastname: Ito
authors.affiliation: World Premier International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS), Namiki 1-1, Tsukuba, Ibaraki 305-0044, Japan.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Bando
authors.affiliation: World Premier International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS), Namiki 1-1, Tsukuba, Ibaraki 305-0044, Japan.
authors.forename: Dmitri
authors.initials: D
authors.lastname: Golberg
mesh_terms: D000067531:Alarmins / Q000378:metabolism; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D015415:Biomarkers / Q000378:metabolism; D001895:Boron / Q000627:therapeutic use* / Q000633:toxicity; D001896:Boron Compounds / Q000627:therapeutic use* / Q000633:toxicity; D045744:Cell Line, Tumor; D048430:Cell Shape / Q000187:drug effects; D055598:Chemical Phenomena; D006801:Humans; D007279:Injections, Subcutaneous; D008297:Male; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D054118:Nanospheres / Q000737:chemistry* / Q000648:ultrastructure; D009336:Necrosis; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D014018:Tissue Distribution / Q000187:drug effects; D023041:Xenograft Model Antitumor Assays
chemical_list: D000067531:Alarmins; D000970:Antineoplastic Agents; D015415:Biomarkers; D001896:Boron Compounds; C017282:boron nitride; D001895:Boron