title: Systolic myocardial volume gain in dilated, hypertrophied and normal heart. CMR study.
abstract: OBJECTIVE
  To investigate changes in myocardial tissue volume during the cardiac cycle to verify the hypothesis of non-compressibility of the myocardium in healthy individuals (HI) as well as in patients with hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), and aortic stenosis (AS).
  
  
  METHODS
  The study group included 30 HI, and patients with HCM (n=110), DCM (n=89), and AS (n=78). Left ventricular (LV) function, end-diastolic, and end-systolic volumes were calculated based on cardiac magnetic resonance imaging (CMR) for all participants.
  
  
  RESULTS
  End-systolic myocardial volumes were higher than end-diastolic in both controls (91.2±26.6 versus 85.1±24.3 ml, p<0.001) and in all patient groups: HCM (214.3±81.6 versus 176±64.2 ml, p<0.01), DCM (128.4±43.1 versus 115.4±42.9 ml, p<0.001) and AS (155.1±37.1 versus 129.4±34.6 ml, p<0.001). HCM and AS patients had significantly higher systolic volume gain than HI (21.5±8.3 versus 10.6±6.3%, p<0.01 and 18.3±5.7 versus 10.6±6.3% p=0.013, respectively). Conversely, DCM patients had lesser increases in myocardial systolic volume than HCM patients (11.2±4.8% versus 21.5±8.3, p=0.01) and AS patients (11.2±4.8% versus 18.3±5.7, p=0.02). No differences were found in systolic volume gain between AS and HCM patients (p=ns) or between DCM patients and HI (p=ns).
  
  
  CONCLUSIONS
  End-systolic myocardial volume was significantly higher than end-diastolic volume in all subsets of patients. The systolic volume gain was greater in individuals with hypertrophy than in those without.
authors.affiliation: Department of Cardiomyopathies, CMR Unit, Institute of Cardiology, Warsaw, Poland. Electronic address: lmazurkiewicz@ikard.pl.
authors.forename: Ł
authors.initials: Ł
authors.lastname: Mazurkiewicz
authors.affiliation: Department of Acquired Cardiac Defects, Institute of Cardiology, Warsaw, Poland.
authors.forename: E
authors.initials: E
authors.lastname: Orłowska-Baranowska
authors.affiliation: Department of Coronary and Structural Heart Diseases, CMR Unit, Institute of Cardiology, Warsaw, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Petryka
authors.affiliation: CMR Unit, Institute of Cardiology, Warsaw, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Śpiewak
authors.affiliation: Department of Cardiomyopathies, Institute of Cardiology, Warsaw, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Gawor
authors.affiliation: CMR Unit, Institute of Cardiology, Warsaw, Poland.
authors.forename: B
authors.initials: B
authors.lastname: Miłosz-Wieczorek
authors.affiliation: CMR Unit, Institute of Cardiology, Warsaw, Poland.
authors.forename: K
authors.initials: K
authors.lastname: Werys
authors.affiliation: Institute of Cardiology, Warsaw, Poland.
authors.forename: Ł A
authors.initials: ŁA
authors.lastname: Małek
authors.affiliation: CMR Unit, Institute of Cardiology, Warsaw, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Marczak
authors.affiliation: Department of Cardiomyopathies, Institute of Cardiology, Warsaw, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Grzybowski
mesh_terms: D000328:Adult; D000368:Aged; D002311:Cardiomyopathy, Dilated / Q000000981:diagnostic imaging* / Q000473:pathology; D002312:Cardiomyopathy, Hypertrophic / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009206:Myocardium / Q000473:pathology*; D009929:Organ Size; D055815:Young Adult