title: Management of early colonic neoplasia: where are we now and where are we heading?
abstract: There have been considerable advances in the endoscopic treatment of colorectal neoplasia. The development of endoscopic submucosal dissection and full thickness resection techniques is changing the way benign disease and early cancers are managed. This article reviews the evidence behind these new techniques and discusses where this field is likely to move in the future. Areas covered: A PubMed literature review of resection techniques for colonic neoplasia was performed. The clinical and cost effectiveness of endoscopic mucosal resection (EMR) is examined. The development of endoscopic submucosal dissection (ESD) and knife assisted resection is described and issues around training reviewed. Efficacy is compared to both EMR and transanal endoscopic microsurgery. The future is considered, including full thickness resection techniques and robotic endoscopy. Expert commentary: The perceived barriers to ESD are falling, and views that such techniques are only possible in Japan are disappearing. The key barriers to uptake will be training, and the development of educational programmes should be seen as a priority. The debate between TEMS and ESD will continue, but ESD is more flexible and cheaper. This will become less significant as the number of endoscopists trained in ESD grows and some TEMS surgeons may shift across towards ESD.
authors.affiliation: a Department of Endoscopy , Queen Alexandra Hospital , Portsmouth , UK.|b Department of Pharmacy and Biomedical sciences , University of Portsmouth , Portsmouth , United Kingdom.
authors.forename: Gaius
authors.initials: G
authors.lastname: Longcroft-Wheaton
authors.affiliation: a Department of Endoscopy , Queen Alexandra Hospital , Portsmouth , UK.|b Department of Pharmacy and Biomedical sciences , University of Portsmouth , Portsmouth , United Kingdom.
authors.forename: Pradeep
authors.initials: P
authors.lastname: Bhandari
mesh_terms: D003110:Colonic Neoplasms / Q000191:economics / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D003362:Cost-Benefit Analysis; D004059:Diffusion of Innovation; D055088:Early Detection of Cancer; D000069916:Endoscopic Mucosal Resection / Q000009:adverse effects / Q000191:economics / Q000401:mortality / Q000639:trends*; D005544:Forecasting; D017048:Health Care Costs; D006801:Humans; D010535:Laparoscopy / Q000009:adverse effects / Q000191:economics / Q000401:mortality / Q000639:trends*; D057605:Natural Orifice Endoscopic Surgery / Q000009:adverse effects / Q000191:economics / Q000401:mortality / Q000639:trends*; D009367:Neoplasm Staging; D065287:Robotic Surgical Procedures / Q000009:adverse effects / Q000191:economics / Q000401:mortality / Q000639:trends*; D016896:Treatment Outcome
keywords: EMR; ESD; Endoscopic submucosal dissection; TEMS; colon; colonoscopy; endoscopic mucosal resection; polyp