title: Quantitative EEG during normal aging: association with the Alzheimer's disease genetic risk variant in PICALM gene.
abstract: Genome-wide association studies have identified novel risk variants for Alzheimer's disease (AD). Among these, a gene carrying one of the highest risks for AD is PICALM. The PICALM rs3851179 A allele is thought to have a protective effect, whereas the G allele appears to confer risk for AD. The influence of the PICALM genotype on brain function in nondemented subjects remains largely unknown. We examined the possible effect of the PICALM rs3851179 genotype on quantitative electroencephalography recording at rest in 137 nondemented volunteers (age range: 20-79 years) subdivided into cohorts of those younger than and those older than 50 years of age. The homozygous presence of the AD risk variant PICALM GG was associated with an increase in beta relative power, with the effect being more pronounced in the older cohort. Beta power elevation in resting-state electroencephalography has previously been linked to cortical disinhibition and hyperexcitability. The increase in beta relative power in the carriers of the AD risk PICALM GG genotype suggests changes in the cortical excitatory-inhibitory balance, which are heightened during normal aging.
authors.affiliation: Research Center of Neurology, Moscow, Russia; Vavilov Institute of General Genetics, RAS, Moscow, Russia. Electronic address: ponomare@yandex.ru.
authors.forename: Natalya V
authors.initials: NV
authors.lastname: Ponomareva
authors.affiliation: Vavilov Institute of General Genetics, RAS, Moscow, Russia; Center of Brain Neurobiology and Neurogenetics, Institute of Cytogenetics and Genetics RAMS, Novosibirsk, Russia.
authors.forename: Tatiana V
authors.initials: TV
authors.lastname: Andreeva
authors.affiliation: Vavilov Institute of General Genetics, RAS, Moscow, Russia.
authors.forename: Maria S
authors.initials: MS
authors.lastname: Protasova
authors.affiliation: Vavilov Institute of General Genetics, RAS, Moscow, Russia.
authors.forename: Lef I
authors.initials: LI
authors.lastname: Shagam
authors.affiliation: Research Center of Neurology, Moscow, Russia.
authors.forename: Daria D
authors.initials: DD
authors.lastname: Malina
authors.affiliation: Vavilov Institute of General Genetics, RAS, Moscow, Russia.
authors.forename: Andrey Yu
authors.initials: AY
authors.lastname: Goltsov
authors.affiliation: Research Center of Neurology, Moscow, Russia.
authors.forename: Vitaly F
authors.initials: VF
authors.lastname: Fokin
authors.affiliation: Research Center of Neurology, Moscow, Russia.
authors.forename: Sergey N
authors.initials: SN
authors.lastname: Illarioshkin
authors.affiliation: Vavilov Institute of General Genetics, RAS, Moscow, Russia; Center of Brain Neurobiology and Neurogenetics, Institute of Cytogenetics and Genetics RAMS, Novosibirsk, Russia; Center of Genetics and Genetic Technologies, Lomonosov Moscow State University, Moscow, Russia; Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, MA, USA. Electronic address: Evgeny.Rogaev@umassmed.edu.
authors.forename: Evgeny I
authors.initials: EI
authors.lastname: Rogaev
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D000544:Alzheimer Disease / Q000235:genetics* / Q000503:physiopathology*; D015331:Cohort Studies; D004569:Electroencephalography; D005260:Female; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D034041:Monomeric Clathrin Assembly Proteins / Q000235:genetics*; D012306:Risk; D055815:Young Adult
chemical_list: D034041:Monomeric Clathrin Assembly Proteins; C439003:PICALM protein, human
keywords: Aging; Alzheimer's disease (AD); Electroencephalography (EEG); PICALM