title: Characteristics, Properties and Analytical Methods of Amoxicillin: A Review with Green Approach.
abstract: Bacterial infections are the second leading cause of global mortality. Considering this fact, it is extremely important studying the antimicrobial agents. Amoxicillin is an antimicrobial agent that belongs to the class of penicillins; it has bactericidal activity and is widely used in the Brazilian health system. In literature, some analytical methods are found for the identification and quantification of this penicillin, which are essential for its quality control, which ensures maintaining the product characteristics, therapeutic efficacy and patient's safety. Thus, this study presents a brief literature review on amoxicillin and the analytical methods developed for the analysis of this drug in official and scientific papers. The major analytical methods found were high-performance liquid chromatography (HPLC), ultra-performance liquid chromatography (U-HPLC), capillary electrophoresis and iodometry and diffuse reflectance infrared Fourier transform. It is essential to note that most of the developed methods used toxic and hazardous solvents, which makes necessary industries and researchers choose to develop environmental-friendly techniques to provide enhanced benefits to environment and staff.
authors.affiliation: a Department of Pharmaceutics, School of Pharmaceutical Sciences , Universidade Estadual Paulista , Araraquara , São Paulo , Brazil.
authors.forename: Bianca Aparecida
authors.initials: BA
authors.lastname: de Marco
authors.affiliation: a Department of Pharmaceutics, School of Pharmaceutical Sciences , Universidade Estadual Paulista , Araraquara , São Paulo , Brazil.
authors.forename: Jéssica Sayuri Hisano
authors.initials: JSH
authors.lastname: Natori
authors.affiliation: a Department of Pharmaceutics, School of Pharmaceutical Sciences , Universidade Estadual Paulista , Araraquara , São Paulo , Brazil.
authors.forename: Stefany
authors.initials: S
authors.lastname: Fanelli
authors.affiliation: a Department of Pharmaceutics, School of Pharmaceutical Sciences , Universidade Estadual Paulista , Araraquara , São Paulo , Brazil.
authors.forename: Eliane Gandolpho
authors.initials: EG
authors.lastname: Tótoli
authors.affiliation: a Department of Pharmaceutics, School of Pharmaceutical Sciences , Universidade Estadual Paulista , Araraquara , São Paulo , Brazil.
authors.forename: Hérida Regina Nunes
authors.initials: HRN
authors.lastname: Salgado
mesh_terms: D000658:Amoxicillin / Q000032:analysis* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000032:analysis* / Q000494:pharmacology; D001424:Bacterial Infections / Q000188:drug therapy*; D002851:Chromatography, High Pressure Liquid; D055772:Green Chemistry Technology / Q000379:methods*; D006801:Humans; D013291:Streptococcus / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D000658:Amoxicillin
keywords: Amoxicillin; analytical methods; antimicrobial; green chemistry; penicillins