title: Type 2 Diabetes Susceptibility in the Greek-Cypriot Population: Replication of Associations with TCF7L2, FTO, HHEX, SLC30A8 and IGF2BP2 Polymorphisms.
abstract: Type 2 diabetes (T2D) has been the subject of numerous genetic studies in recent years which revealed associations of the disease with a large number of susceptibility loci. We hereby initiate the evaluation of T2D susceptibility loci in the Greek-Cypriot population by performing a replication case-control study. One thousand and eighteen individuals (528 T2D patients, 490 controls) were genotyped at 21 T2D susceptibility loci, using the allelic discrimination method. Statistically significant associations of T2D with five of the tested single nucleotide polymorphisms (SNPs) (TCF7L2rs7901695,FTOrs8050136,HHEXrs5015480,SLC30A8rs13266634 andIGF2BP2rs4402960) were observed in this study population. Furthermore, 14 of the tested SNPs had odds ratios (ORs) in the same direction as the previously published studies, suggesting that these variants can potentially be used in the Greek-Cypriot population for predictive testing of T2D. In conclusion, our findings expand the genetic assessment of T2D susceptibility loci and reconfirm five of the worldwide established loci in a distinct, relatively small, newly investigated population.
authors.affiliation: Department of Neurogenetics, The Cyprus Institute of Neurology and Genetics and the Cyprus School of Molecular Medicine, Ayios Dhometios, 2370 Nicosia, Cyprus. votsi@cing.ac.cy.
authors.forename: Christina
authors.initials: C
authors.lastname: Votsi
authors.affiliation: Department of Endocrinology and Diabetes, Hippocrateon Private Hospital, Engomi, 2408 Nicosia, Cyprus. c.toufexis@hippocrateon.com.
authors.forename: Costas
authors.initials: C
authors.lastname: Toufexis
authors.affiliation: Department of Electron Microscopy/Molecular Pathology, The Cyprus Institute of Neurology and Genetics, Ayios Dhometios, 2370 Nicosia, Cyprus. kyriakimi@cing.ac.cy.
authors.forename: Kyriaki
authors.initials: K
authors.lastname: Michailidou
authors.affiliation: Department of Computer Science, University of Cyprus, 1678 Nicosia, Cyprus. athos.antoniades@stremble.com.
authors.forename: Athos
authors.initials: A
authors.lastname: Antoniades
authors.affiliation: St. George's University Medical School at the University of Nicosia, Engomi, 2408 Nicosia, Cyprus and Department of Pediatric Endocrinology, Paedi Center for Specialized Pediatrics, Strovolos, 2025 Nicosia, Cyprus. nskordis@cytanet.com.cy.
authors.forename: Nicos
authors.initials: N
authors.lastname: Skordis
authors.affiliation: Department of Computer Science, University of Cyprus, 1678 Nicosia, Cyprus. karaolis@spidernet.com.cy.
authors.forename: Minas
authors.initials: M
authors.lastname: Karaolis
authors.affiliation: Department of Computer Science, University of Cyprus, 1678 Nicosia, Cyprus. pattichi@ucy.ac.cy.
authors.forename: Constantinos S
authors.initials: CS
authors.lastname: Pattichis
authors.affiliation: Department of Neurogenetics, The Cyprus Institute of Neurology and Genetics and the Cyprus School of Molecular Medicine, Ayios Dhometios, 2370 Nicosia, Cyprus. roula@cing.ac.cy.
authors.forename: Kyproula
authors.initials: K
authors.lastname: Christodoulou
keywords: Greek-Cypriot population; association studies; population studies; susceptibility loci; type 2 diabetes