title: Significant correlation between renal123I-metaiodobenzylguanidine scintigraphy and muscle sympathetic nerve activity in patients with primary hypertension.
abstract: Iodine-123 metaiodobenzylguanidine (123I-MIBG) scintigraphy is used as a noninvasive imaging method for assessing cardiac sympathetic nerve activity. We tested the hypothesis that renal123I-MIBG imaging is correlated with muscle sympathetic nerve activity (MSNA) in patients with primary hypertension.
  
  
  
  Thirty-one consecutive patients with primary hypertension were included. Multiunit MSNA was recorded from the peroneal nerve to evaluate direct efferent sympathetic nerve activity. Planar renal and cardiac123I-MIBG images were acquired. Early and delayed kidney-to-mediastinum ratio (K/M), early and delayed heart-to-mediastinum ratio (H/M), and washout rates (WR) were calculated.
  
  
  
  In 27 of 31 patients, blood pressure was controlled on antihypertensive medication. Mean systolic and diastolic blood pressures were 118 ± 18 and 67 ± 15 mmHg, respectively. Although early and late K/M and H/M were not significantly correlated with MSNA, both cardiac and average renal WR were significantly correlated with MSNA (r = 0.45, P = .0035 and r = 0.68, P < .001, respectively). Right and left renal WR were similarly correlated with MSNA. Renal WR was significantly higher than cardiac WR (43.2% vs 25.8%, P < .001) in these patients with hypertension.
  
  
  
  Renal123I-MIBG WR was significantly associated with multiunit MSNA. Renal123I-MIBG imaging offers a noninvasive clinical methodology for assessing renal sympathetic nerve function.
authors.affiliation: Department of Disease Control and Homeostasis, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-8641, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Takamura
authors.affiliation: Department of Disease Control and Homeostasis, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-8641, Japan. sakurasoma1209@yahoo.co.jp.
authors.forename: Hisayoshi
authors.initials: H
authors.lastname: Murai
authors.affiliation: Department of Disease Control and Homeostasis, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-8641, Japan.
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Okabe
authors.affiliation: Department of Cardiology, Osaka General Medical Center, Osaka, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Okuyama
authors.affiliation: Department of Disease Control and Homeostasis, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-8641, Japan.
authors.forename: Takuto
authors.initials: T
authors.lastname: Hamaoka
authors.affiliation: Department of Disease Control and Homeostasis, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-8641, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Mukai
authors.affiliation: Department of Disease Control and Homeostasis, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-8641, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Tokuhisa
authors.affiliation: Department of Disease Control and Homeostasis, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-8641, Japan.
authors.forename: Oto
authors.initials: O
authors.lastname: Inoue
authors.affiliation: Department of Disease Control and Homeostasis, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-8641, Japan.
authors.forename: Shin-Ichiro
authors.initials: SI
authors.lastname: Takashima
authors.affiliation: Department of Disease Control and Homeostasis, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-8641, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kato
authors.affiliation: Department of Nuclear Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
authors.forename: Shinro
authors.initials: S
authors.lastname: Matsuo
authors.affiliation: Department of Disease Control and Homeostasis, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-8641, Japan.
authors.forename: Soichiro
authors.initials: S
authors.lastname: Usui
authors.affiliation: Department of Disease Control and Homeostasis, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-8641, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Furusho
authors.affiliation: Department of Disease Control and Homeostasis, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-8641, Japan.
authors.forename: Shuichi
authors.initials: S
authors.lastname: Kaneko
mesh_terms: D019797:3-Iodobenzylguanidine; D000328:Adult; D005260:Female; D006801:Humans; D006973:Hypertension / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D007668:Kidney / Q000000981:diagnostic imaging* / Q000294:innervation / Q000503:physiopathology*; D008297:Male; D018482:Muscle, Skeletal / Q000000981:diagnostic imaging / Q000294:innervation / Q000503:physiopathology*; D049268:Positron-Emission Tomography / Q000379:methods; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013564:Sympathetic Nervous System / Q000000981:diagnostic imaging / Q000503:physiopathology*
chemical_list: D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine
keywords: 123I-MIBG; Hypertension; iodine-123 metaiodobenzylguanidine imaging; muscle sympathetic nerve activity