title: [Predictive factors of complications during CT-guided transthoracic biopsy].
abstract: BACKGROUND
  CT-guided transthoracic core-needle biopsy (TTNB) is frequently used for the diagnosis of lung nodules. The aim of this study is to describe TTNBs' complications and to investigate predictive factors of complications.
  
  
  METHODS
  All consecutive TTNBs performed in three centers between 2006 and 2012 were included. Binary logistic regression was used for multivariate analysis.
  
  
  RESULTS
  Overall, 970 TTNBs were performed in 929 patients. The complication rate was 34% (life-threatening complication in 6%). The most frequent complications were pneumothorax (29% included 4% which required chest-tube) and hemoptysis (5%). The mortality rate was 0.1% (n=1). In multivariate analysis, predictive factor for a complication was small target size (AOR=0.984; 95% CI [0.976-0.992]; P<0.001). This predictive factor was also found for occurrence of life-threatening complication (AOR=0.982; [0.965-0.999]; P=0.037), of pneumothorax (AOR=0.987; [0.978-0.995]; P=0.002) and of hemoptysis (AOR=0.973; [0.951-0.997]; P=0.024).
  
  
  CONCLUSIONS
  One complication occurred in one-third of TTNBs. The proportion of life-threatening complication was 6%. A small lesion size was predictive of complication occurrence.
authors.affiliation: Service de pneumologie aiguë spécialisée et oncologie thoracique, hospices civils de Lyon, centre hospitalier Lyon Sud, 165, chemin du Grand-Revoyet, 69495 Pierre-Bénite, France; Faculté de médecine Lyon Sud, université Lyon 1, 69600 Oullins, France. Electronic address: Clara.fontaine-delaruelle@chu-lyon.fr.
authors.forename: C
authors.initials: C
authors.lastname: Fontaine-Delaruelle
authors.affiliation: Service de pneumologie aiguë spécialisée et oncologie thoracique, hospices civils de Lyon, centre hospitalier Lyon Sud, 165, chemin du Grand-Revoyet, 69495 Pierre-Bénite, France; EMR 3738, ciblage thérapeutique en oncologie, faculté de médecine Lyon Sud, université Lyon 1, 69600 Oullins, France.
authors.forename: P-J
authors.initials: PJ
authors.lastname: Souquet
authors.affiliation: Service d'imagerie, hospices civils de Lyon, centre hospitalier Louis-Pradel, 69500 Bron, France.
authors.forename: D
authors.initials: D
authors.lastname: Gamondes
authors.affiliation: DiM, centre hospitalier Lyon Sud, 69495 Pierre-Bénite, France.
authors.forename: E
authors.initials: E
authors.lastname: Pradat
authors.affiliation: Service d'imagerie, hospices civils de Lyon, centre hospitalier Lyon Sud, 69495 Pierre-Bénite, France.
authors.forename: A
authors.initials: A
authors.lastname: de Leusse
authors.affiliation: Clinique universitaire de radiologie et imagerie médicale, centre hospitalier universitaire Grenoble, 38043 Grenoble, France; Université Grenoble Alpes, 38000 Grenoble, France; Inserm U 823, institut A.-Bonniot, 38700 la Tronche, France.
authors.forename: G R
authors.initials: GR
authors.lastname: Ferretti
authors.affiliation: Service de pneumologie aiguë spécialisée et oncologie thoracique, hospices civils de Lyon, centre hospitalier Lyon Sud, 165, chemin du Grand-Revoyet, 69495 Pierre-Bénite, France; EMR 3738, ciblage thérapeutique en oncologie, faculté de médecine Lyon Sud, université Lyon 1, 69600 Oullins, France.
authors.forename: S
authors.initials: S
authors.lastname: Couraud
mesh_terms: D000368:Aged; D001707:Biopsy, Needle / Q000009:adverse effects; D005260:Female; D006469:Hemoptysis / Q000453:epidemiology / Q000473:pathology; D006801:Humans; D061705:Image-Guided Biopsy / Q000009:adverse effects / Q000379:methods; D008175:Lung Neoplasms / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011030:Pneumothorax / Q000453:epidemiology / Q000473:pathology; D011183:Postoperative Complications / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology*; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D014057:Tomography, X-Ray Computed / Q000009:adverse effects / Q000379:methods
keywords: Biopsie guidée par imagerie; Computed Tomography; Hemoptysis; Hémoptysie; Image-guided biopsy; Pneumothorax; Thorax; Tomodensitométrie