title: Delayed Diagnosis of a Nasal Type Lymphoma Misdiagnosed as Persistent Sinusitis.
abstract: Nasal Type T/natural killer (NK)-cell lymphomas are rare clinical entities, highly aggressive with a very poor prognosis. We present a case of a 37-year-old immunocompetent man presenting with deep palatal ulceration and a 3-month history of symptoms, which appear to have been misdiagnosed by physicians. The final diagnosis was achieved by a 15-day diagnostic algorithm, during which time the clinical status of the patient worsened severely. In this article, we also provide a succinct update on the clinical and histopathological findings of Peripheral T/NK-cell lymphomas and propose that symptoms that are consistent with these clinical entities should be considered from the early stages to inform a suitable diagnostic pathway Because of their highly aggressive behavior, we suggest that early therapy of T/NK-cell lymphomas may be started before completing the specific diagnostic investigations.
authors.affiliation: 1 Department of Neuroscience, Reproductive and Odontostomatological Sciences, University Federico II of Naples, Naples, Italy .|2 The University of Melbourne , Melbourne Dental School and Oral Health CRC, Melbourne, Australia .
authors.forename: Antonio
authors.initials: A
authors.lastname: Celentano
authors.affiliation: 3 Pathology Section, Department of Advanced Biomedical Sciences, University Federico II of Naples , Naples, Italy .
authors.forename: Massimo
authors.initials: M
authors.lastname: Mascolo
authors.affiliation: 2 The University of Melbourne , Melbourne Dental School and Oral Health CRC, Melbourne, Australia .
authors.forename: Nicola
authors.initials: N
authors.lastname: Cirillo
authors.affiliation: 3 Pathology Section, Department of Advanced Biomedical Sciences, University Federico II of Naples , Naples, Italy .
authors.forename: Gaetano
authors.initials: G
authors.lastname: De Rosa
authors.affiliation: 1 Department of Neuroscience, Reproductive and Odontostomatological Sciences, University Federico II of Naples, Naples, Italy .
authors.forename: Michele Davide
authors.initials: MD
authors.lastname: Mignogna
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001215:Asparaginase / Q000008:administration & dosage; D002908:Chronic Disease; D057210:Delayed Diagnosis; D003907:Dexamethasone / Q000008:administration & dosage; D003951:Diagnostic Errors; D005047:Etoposide / Q000008:administration & dosage; D005402:Fistula; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D002955:Leucovorin / Q000008:administration & dosage; D054391:Lymphoma, Extranodal NK-T-Cell / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D008297:Male; D015523:Maxillary Sinusitis / Q000175:diagnosis*; D008727:Methotrexate / Q000008:administration & dosage; D009059:Mouth Diseases; D009668:Nose Diseases; D009669:Nose Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D010157:Palatal Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D011878:Radiotherapy
chemical_list: D005047:Etoposide; D003907:Dexamethasone; D001215:Asparaginase; D002955:Leucovorin; D007069:Ifosfamide; D008727:Methotrexate
keywords: NHL; lymphoma; nasal type lymphoma