title: Ang-1 and Ang-2 expression in angiomyolipoma and PEComa family tumors.
abstract: OBJECTIVE
  Perivascular epithelioid cell tumors (PEComa) are an uncommon family of soft tissue tumors. Previously, we described that the presence of pericyte antigens among PEComa family tumors differs extensively by histologic appearance.
  
  
  METHODS
  Here, we extend our findings using the pericyte antigens Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2), using immunohistochemical detection in human tumor samples.
  
  
  RESULTS
  While Ang-1 showed no expression across any PEComa family tumor, Ang-2 showed expression that like other pericyte markers was largely determined by cytologic appearance.
  
  
  CONCLUSIONS
  Pericytic marker expression in PEComa may represent a true pericytic cell of origin, or alternatively aberrant pericyte marker adoption.
authors.affiliation: School of Dentistry, University of California, Los Angeles, USA.
authors.forename: Swati
authors.initials: S
authors.lastname: Shrestha
authors.affiliation: Department of Pathology, The Johns Hopkins University, Baltimore, MD, USA.
authors.forename: Carolyn
authors.initials: C
authors.lastname: Meyers
authors.affiliation: School of Dentistry, University of California, Los Angeles, USA.
authors.forename: Jia
authors.initials: J
authors.lastname: Shen
authors.affiliation: School of Dentistry, University of California, Los Angeles, USA.
authors.forename: Paulina
authors.initials: P
authors.lastname: Giacomelli
authors.affiliation: Nationwide Children's Hospital, Columbus, OH, USA.
authors.forename: Michelle A
authors.initials: MA
authors.lastname: Scott
authors.affiliation: Orthopedic Hospital Research Center, University of California, Los Angeles, USA; Department of Surgery, University of California, Los Angeles, Los Angeles, CA, USA.
authors.forename: Chia
authors.initials: C
authors.lastname: Soo
authors.affiliation: Department of Pathology, The Johns Hopkins University, Baltimore, MD, USA.
authors.forename: Sarah M
authors.initials: SM
authors.lastname: Dry
authors.affiliation: School of Dentistry, University of California, Los Angeles, USA.
authors.forename: Kang
authors.initials: K
authors.lastname: Ting
authors.affiliation: Department of Pathology, The Johns Hopkins University, Baltimore, MD, USA; Orthopedic Hospital Research Center, University of California, Los Angeles, USA.
authors.forename: Aaron W
authors.initials: AW
authors.lastname: James
keywords: Angiomyolipoma; Angiopoietin; Lymphangiomyoma; PEComa; Pericyte; Perivascular epithelioid cell tumor