title: Hacking the Matrix.
abstract: Recently in Nature, Gjorevski et al. (2016) describe a fully defined synthetic hydrogel that mimics the extracellular matrix to support in vitro growth of intestinal stem cells and organoids. The hydrogel allows exquisite control over the chemical and physical in vitro niche and enables identification of regulatory properties of the matrix.
authors.affiliation: Department of Internal Medicine, Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, MI 48109-5624, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Czerwinski
authors.affiliation: Department of Internal Medicine, Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, MI 48109-5624, USA; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109-5624, USA; Center for Organogenesis, University of Michigan Medical School, Ann Arbor, MI 48109-5624, USA. Electronic address: spencejr@umich.edu.
authors.forename: Jason R
authors.initials: JR
authors.lastname: Spence
mesh_terms: D005109:Extracellular Matrix / Q000737:chemistry; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000032:analysis*; D007422:Intestines; D009940:Organoids; D013234:Stem Cells
chemical_list: D020136:Hydrogel, Polyethylene Glycol Dimethacrylate