title: Comparison of global myocardial strain assessed by cardiovascular magnetic resonance tagging and feature tracking to infarct size at predicting remodelling following STEMI.
abstract: To determine if global strain parameters measured by cardiovascular magnetic resonance (CMR) acutely following ST-segment Elevation Myocardial Infarction (STEMI) predict adverse left ventricular (LV) remodelling independent of infarct size (IS).
  
  
  
  Sixty-five patients with acute STEMI (mean age 60 ± 11 years) underwent CMR at 1-3 days post-reperfusion (baseline) and at 4 months. Global peak systolic circumferential strain (GCS), measured by tagging and Feature Tracking (FT), and global peak systolic longitudinal strain (GLS), measured by FT, were calculated at baseline, along with IS. On follow up scans, volumetric analysis was performed to determine the development of adverse remodelling - a composite score based on development of either end-diastolic volume index [EDVI] ≥20% or end-systolic volume index [ESVI] ≥15% at follow-up compared to baseline.
  
  
  
  The magnitude of GCS was higher when measured using FT (-21.1 ± 6.3%) than with tagging (-12.1 ± 4.3; p < 0.001 for difference). There was good correlation of strain with baseline LVEF (r 0.64-to 0.71) and IS (ρ -0.62 to-0.72). Baseline strain parameters were unable to predict development of adverse LV remodelling. Only baseline IS predicted adverse remodelling - Odds Ratio 1.05 (95% CI 1.01-1.10, p = 0.03), area under the ROC curve 0.70 (95% CI 0.52-0.87, p = 0.04).
  
  
  
  Baseline global strain by CMR does not predict the development of adverse LV remodelling following STEMI.
authors.affiliation: Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Groby Road, Leicester, LE3 9QF, UK.|Oxford University Hospitals NHS Trust, Oxford, OX3 9DU, UK.
authors.forename: Abhishek M
authors.initials: AM
authors.lastname: Shetye
authors.affiliation: Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Groby Road, Leicester, LE3 9QF, UK.
authors.forename: Sheraz A
authors.initials: SA
authors.lastname: Nazir
authors.affiliation: Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Groby Road, Leicester, LE3 9QF, UK.|Ipswich Hospital NHS trust, Ipswich, IP4 5PD, UK.
authors.forename: Naveed A
authors.initials: NA
authors.lastname: Razvi
authors.affiliation: Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Groby Road, Leicester, LE3 9QF, UK.|Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, LS2 9JT, UK.
authors.forename: Nathan
authors.initials: N
authors.lastname: Price
authors.affiliation: Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Groby Road, Leicester, LE3 9QF, UK.
authors.forename: Jamal N
authors.initials: JN
authors.lastname: Khan
authors.affiliation: Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Groby Road, Leicester, LE3 9QF, UK.
authors.forename: Florence Y
authors.initials: FY
authors.lastname: Lai
authors.affiliation: Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Groby Road, Leicester, LE3 9QF, UK.
authors.forename: Iain B
authors.initials: IB
authors.lastname: Squire
authors.affiliation: Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Groby Road, Leicester, LE3 9QF, UK.
authors.forename: Gerald P
authors.initials: GP
authors.lastname: McCann
authors.affiliation: Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Groby Road, Leicester, LE3 9QF, UK. jra14@le.ac.uk.
authors.forename: Jayanth R
authors.initials: JR
authors.lastname: Arnold
mesh_terms: D000368:Aged; D019540:Area Under Curve; D001696:Biomechanical Phenomena; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D016015:Logistic Models; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D016017:Odds Ratio; D011237:Predictive Value of Tests; D011379:Prognosis; D012372:ROC Curve; D015203:Reproducibility of Results; D000072657:ST Elevation Myocardial Infarction / Q000000981:diagnostic imaging* / Q000503:physiopathology; D013314:Stress, Mechanical; D013997:Time Factors; D016277:Ventricular Function, Left; D020257:Ventricular Remodeling
keywords: Cardiac magnetic resonance; Feature tracking; Remodelling; ST-elevation myocardial infarction; Strain; Tagging