title: S-glycosides in medicinal chemistry: Novel synthesis of cyanoethylene thioglycosides and their pyrazole derivatives.
abstract: A one-pot reaction of a sodium 2-cyanoethylene-1-thiolate salt with 2,3,4,6-tetra-O-acetyl-α-D-gluco- and galactopyranosyl bromides affords a new class of cyanoethylene thioglycosides. The conversion to the corresponding 5-aminopyrazoles confirms the E-configuration of these cyanoethylene thioglycosides.
authors.affiliation: a Chemistry Department , Faculty of Science, Helwan University , Helwan , Cairo , Egypt.
authors.forename: Galal
authors.initials: G
authors.lastname: Elgemeie
authors.affiliation: b Photochemistry Department , National Research Centre , Dokki , Cairo , Egypt.
authors.forename: Nahed
authors.initials: N
authors.lastname: Fathy
authors.affiliation: c Pharmaceutical Chemistry Department , Faculty of Pharmacy, Helwan University , Helwan , Cairo , Egypt.
authors.forename: Wafaa
authors.initials: W
authors.lastname: Zaghary
authors.affiliation: d Pharmaceutical Chemistry Department , Faculty of Pharmacy, Ahram Canadian University , Giza , Egypt.
authors.forename: Ayman
authors.initials: A
authors.lastname: Farag
mesh_terms: D060326:Chemistry Techniques, Synthetic; D002626:Chemistry, Pharmaceutical / Q000379:methods; D005030:Ethylenes / Q000737:chemistry; D006027:Glycosides / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D011720:Pyrazoles / Q000737:chemistry; D013865:Thioglycosides / Q000138:chemical synthesis
chemical_list: D005030:Ethylenes; D006027:Glycosides; D011720:Pyrazoles; D013865:Thioglycosides
keywords: Cyanoethylene; cyanoethylene thioglycosides; pyrazoles; sodium 2-cyanoethylene-1-thiolate salts; thioglycosides