title: The Use of Topical Non-steroidal Anti-inflammatory Drugs for Uveitic Cystoid Macular Edema.
abstract: The use of topical non-steroidal anti-inflammatory drugs in the management of uveitic cystoid macular edema is controversial. In this letter, we review the literature and report our results from a retrospective case series of 281 patients taking topical nepafenac 0.1% for uveitic cystoid macular edema between 2010 and 2016. Over a 4-month period, there was a modest improvement in best-corrected visual acuity (0.66 ± 3.7 logMAR) and central macular thickness (69.8 ± 132.5 μm). Patients with idiopathic anterior uveitis and HLA-B*27-associated anterior uveitis recovered more vision while taking topical nepafenac 0.1%, than those with other uveitides, however, this was not statistically significant. There is a need for controlled prospective studies to evaluate the efficacy of topical non-steroidal anti-inflammatory drugs in the management of uveitic cystoid macular edema. At present, clinicians have little evidence on which to base practice.
authors.affiliation: a Medical Retina Department , Moorfields Eye Hospital , London , UK.
authors.forename: Harry
authors.initials: H
authors.lastname: Petrushkin
authors.affiliation: a Medical Retina Department , Moorfields Eye Hospital , London , UK.
authors.forename: Duncan
authors.initials: D
authors.lastname: Rogers
authors.affiliation: a Medical Retina Department , Moorfields Eye Hospital , London , UK.
authors.forename: Carlos
authors.initials: C
authors.lastname: Pavesio
mesh_terms: D000287:Administration, Topical; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage; D044482:Benzeneacetamides / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008266:Macula Lutea / Q000473:pathology; D008269:Macular Edema / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010648:Phenylacetates / Q000008:administration & dosage*; D041623:Tomography, Optical Coherence; D014605:Uveitis / Q000150:complications*; D014792:Visual Acuity
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D044482:Benzeneacetamides; D010648:Phenylacetates; C414203:nepafenac
keywords: Cystoid macular edema; NSAIDs; nepafenac; nevanac; non-steroidal anti-inflammatory drugs; uveitic; uveitis