title: Outcomes in Patients with pT1-T2, pN0-N1 Breast Cancer After Conservative Surgery and Whole-breast Radiotherapy.
abstract: To evaluate locoregional recurrence, overall survival, disease-free survival and prognostic influence of the number of positive lymph nodes and other variables in breast cancer treatment.
  
  
  
  A total of 377 patients with pT1-T2, pN0-N1 invasive breast carcinoma treated from 2005 to 2013 were retrospectively evaluated. Patients underwent conservative surgery followed by whole-breast radiotherapy. Clavicular region irradiation was not performed.
  
  
  
  With a median follow-up of 4 years, locoregional recurrence rate was 3.4% (nodal recurrence=1.06%). Expression of progesterone receptors was significantly associated with better disease-free survival, tumor size (T>2 cm) with poorer disease-free survival, locoregional recurrence and poorer overall survival; the presence of three nodal metastases was related to significantly poorer overall survival (p=0.024).
  
  
  
  Whole-breast adjuvant radiotherapy without nodal irradiation after breast-conserving surgery led to low rate of locoregional recurrence and high rates of overall survival and disease-free survival in patients with pT1-T2 pN0-N1 breast cancer.
authors.affiliation: Department of Radiation Oncology, SS. Annunziata Hospital, G. D'Annunzio University of Chieti, Chieti, Italy.
authors.forename: Marianna
authors.initials: M
authors.lastname: Trignani
authors.affiliation: Department of Radiation Oncology, SS. Annunziata Hospital, G. D'Annunzio University of Chieti, Chieti, Italy.
authors.forename: Clelia
authors.initials: C
authors.lastname: DI Carlo
authors.affiliation: Department of Radiation Oncology, SS. Annunziata Hospital, G. D'Annunzio University of Chieti, Chieti, Italy.
authors.forename: Carmen
authors.initials: C
authors.lastname: Cefalogli
authors.affiliation: Department of Radiation Oncology, SS. Annunziata Hospital, G. D'Annunzio University of Chieti, Chieti, Italy.
authors.forename: Marianna
authors.initials: M
authors.lastname: Nuzzo
authors.affiliation: Department of Radiation Oncology, SS. Annunziata Hospital, G. D'Annunzio University of Chieti, Chieti, Italy.
authors.forename: Lucia Anna
authors.initials: LA
authors.lastname: Ursini
authors.affiliation: Department of Radiation Oncology, SS. Annunziata Hospital, G. D'Annunzio University of Chieti, Chieti, Italy.
authors.forename: Luciana
authors.initials: L
authors.lastname: Caravatta
authors.affiliation: Department of Radiation Oncology, SS. Annunziata Hospital, G. D'Annunzio University of Chieti, Chieti, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Perrotti
authors.affiliation: Laboratory of Biostatistics, Department of Medical, Oral and Biotechnological Sciences, G. D'Annunzio University of Chieti, Chieti, Italy.
authors.forename: Marta
authors.initials: M
authors.lastname: DI Nicola
authors.affiliation: Division of Hygene, Epidemiology and Public Health, Department of Medicine and Science of Aging, G. D'Annunzio University of Chieti, Chieti, Italy.
authors.forename: Ambra
authors.initials: A
authors.lastname: Pamio
authors.affiliation: Department of Radiation Oncology, SS. Annunziata Hospital, G. D'Annunzio University of Chieti, Chieti, Italy d.genovesi@unich.it.
authors.forename: Domenico
authors.initials: D
authors.lastname: Genovesi
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008408:Mastectomy / Q000401:mortality*; D008875:Middle Aged; D060787:Neoplasm Grading; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D009367:Neoplasm Staging; D011379:Prognosis; D018714:Radiotherapy, Adjuvant / Q000401:mortality*; D012189:Retrospective Studies; D015996:Survival Rate
keywords: Breast cancer; adjuvant radiotherapy; conservative surgery; pN0-N1; pT1-T2