title: Association between reductions in low-density lipoprotein cholesterol with statin therapy and the risk of new-onset diabetes: a meta-analysis.
abstract: A recent meta-analysis demonstrated that statin therapy was associated with a risk of diabetes. The present study investigated whether the relative reduction in low-density lipoprotein cholesterol (LDL-c) was a good indicator of the risk of new-onset diabetes. We searched the PubMed, Embase, Cochrane Central Register, Lilacs, Food and Drug Administration, and European Medicines Agency databases for randomized controlled trials of statins. Fourteen trials were included in the study. Eight trials with target LDL-c levels ≤100 mg/dL (2.6 mmol/L) or LDL-c reductions of at least 30% were extracted separately. The results showed that the overall risk of incident diabetes increased by 11% (OR = 1.11; 95% CI 1.03-1.20). The group with intensive LDL-c-lowering statin had an 18% increase in the likelihood of developing diabetes (OR = 1.18; 95% CI, 1.10-1.28). Furthermore, the risks of incident diabetes were 13% (OR = 1.13; 95% CI 1.01-1.26) and 29% (OR = 1.29; 95% CI 1.13-1.47) in the subgroups with 30-40% and 40-50% reductions in LDL-c, respectively, suggesting that LDL-c reduction may provide a dynamic risk assessment parameter for new-onset diabetes. In conclusion, LDL-c reduction is positively related to the risk of new-onset diabetes. When LDL-c is reduced by more than 30% during lipid-lowering therapy, blood glucose monitoring is suggested to detect incident diabetes in high-risk populations.
authors.affiliation: Department of Endocrinology, the affiliated Zhongda Hospital of Southeast University, No. 87 DingJiaQiao Road, Nanjing, P.R. China.
authors.forename: Shaohua
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Endocrinology, the affiliated Zhongda Hospital of Southeast University, No. 87 DingJiaQiao Road, Nanjing, P.R. China.
authors.forename: Rongrong
authors.initials: R
authors.lastname: Cai
authors.affiliation: Department of Endocrinology, the affiliated Zhongda Hospital of Southeast University, No. 87 DingJiaQiao Road, Nanjing, P.R. China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: John Moorhead Research Laboratory, Centre for Nephrology, University College London Medical School, Royal Free Campus, London, UK.
authors.forename: Zac
authors.initials: Z
authors.lastname: Varghese
authors.affiliation: John Moorhead Research Laboratory, Centre for Nephrology, University College London Medical School, Royal Free Campus, London, UK.
authors.forename: John
authors.initials: J
authors.lastname: Moorhead
authors.affiliation: AstraZeneca-Shenzhen University Joint Institute of Nephrology, Centre for Nephrology &Urology, Department of Physiology, Shenzhen University Health Science Center, Shenzhen, P.R. China.|John Moorhead Research Laboratory, Centre for Nephrology, University College London Medical School, Royal Free Campus, London, UK.
authors.forename: Xiong Z
authors.initials: XZ
authors.lastname: Ruan
mesh_terms: D001786:Blood Glucose / Q000032:analysis; D008078:Cholesterol, LDL / Q000097:blood*; D002986:Clinical Trials as Topic; D016208:Databases, Factual; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D006937:Hypercholesterolemia / Q000473:pathology / Q000517:prevention & control; D015994:Incidence; D016017:Odds Ratio; D012307:Risk Factors
chemical_list: D001786:Blood Glucose; D008078:Cholesterol, LDL; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors