title: Trend in young coronary artery disease in China from 2010 to 2014: a retrospective study of young patients ≤ 45.
abstract: The incidence of young coronary heart disease (CHD, ≤45 years) in China is increasing. Secondary prevention to counter this trend is an important contemporary public health issure.
  
  
  
  A total of 5288 patients (≤45 years) diagnosed with CHD and hospitalized at the Chinese PLA General Hospital and Anzhen Hospital, both in Beijing, were enrolled after satisfying the inclusion criteria.
  
  
  
  Young CHD patients increased in number from 2010 to 2014, especially men. Among the studied patients, there was no significant change over those years in blood pressure, but heart rate increased significantly (P < 0.05) and body mass index showed a rising trend (P > 0.05). The incidence of hypertension increased from 40.7 to 47.5%, diabetes from 20.3 to 26.1%, and hyperlipidemia from 27.3 to 35.7% (P < 0.05). However, the incidences of smoking and drinking both trended downward (P < 0.05). The levels of total cholesterol and triglycerides also showed a downward trend (P < 0.05), as did levels of low-density lipoprotein, but not to the point of statistical significance (P > 0.05). Mortality during hospitalization decreased significantly from 2010 to 2014 (P < 0.05), but there was no significant improvement in the incidences of cardiac death and major adverse cardiovascular events (MACE) after 1-year follow-up (P > 0.05).
  
  
  
  Over the 5 years studied, the overall incidence of cardiac death and MACE for young CHD patients (≤45 years) has shown little improvement. Secondary prevention of young CHD, and its risk factors, as well as appropriate courses of medical treatment must be further elucidated.
authors.affiliation: Department of Health Statistics, School of Public Health, Fourth Military Medical University, Xi'an, Shanxi Province, China.|Center For Disease Control And Prevention Of The PAP, Beijing, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Cardiology, PLA General Hospital, Beijing, 100853, China.|ICU of The first phase Beijing Tsinghua Changgeng Hospital, Beijing, 100044, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Gao
authors.affiliation: Department of Cardiology, PLA General Hospital, Beijing, 100853, China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Zhou
authors.affiliation: Department of Cardiology, PLA General Hospital, Beijing, 100853, China.|AnZhen Hospital, Capital Medical University, Beijing, 100029, China.
authors.forename: Jinwen
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Cardiology, PLA General Hospital, Beijing, 100853, China.|Department of Cardiology of AnZhen Hospital, Beijing, 100029, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
authors.affiliation: Department of Cardiology, PLA General Hospital, Beijing, 100853, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Tian
authors.affiliation: Department of Cardiology, PLA General Hospital, Beijing, 100853, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Jin
authors.affiliation: Department of Cardiology, PLA General Hospital, Beijing, 100853, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Ma
authors.affiliation: Department of Cardiology, PLA General Hospital, Beijing, 100853, China.
authors.forename: Xiaodi
authors.initials: X
authors.lastname: Xue
authors.affiliation: Department of Cardiology, PLA General Hospital, Beijing, 100853, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Cardiology, PLA General Hospital, Beijing, 100853, China. ametuofo980869@163.com.
authors.forename: Yuqi
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Cardiology, PLA General Hospital, Beijing, 100853, China. cyundai@vip.163.com.
authors.forename: Yundai
authors.initials: Y
authors.lastname: Chen
mesh_terms: D000328:Adult; D017677:Age Distribution; D017668:Age of Onset; D000428:Alcohol Drinking / Q000009:adverse effects / Q000453:epidemiology; D002681:China / Q000453:epidemiology; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality / Q000628:therapy; D003920:Diabetes Mellitus / Q000453:epidemiology; D005260:Female; D006760:Hospitalization; D006801:Humans; D006949:Hyperlipidemias / Q000453:epidemiology; D006973:Hypertension / Q000453:epidemiology; D015994:Incidence; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D017678:Sex Distribution; D012907:Smoking / Q000009:adverse effects / Q000453:epidemiology; D013997:Time Factors
keywords: Coronary heart disease; Prevention; Prognosis; Risk factors; Young