title: Preparation of a Salecan/poly(2-acrylamido-2-methylpropanosulfonic acid-co-[2-(methacryloxy)ethyl]trimethylammonium chloride) Semi-IPN Hydrogel for Drug Delivery.
abstract: Salecan is a water-soluble bacterial polysaccharide consisting of glucopyranosyl units linked by α-1,3 and β-1,3 glycosidic bonds. salecan is suitable for the development of hydrogels for biomedical applications, given its outstanding physicochemical and biological profiles. In this study we designed a new semi-interpenetrating polymer network hydrogel that introduces the salecan polysaccharide into a stimuli-responsive poly(2-acrylamido-2-methylpropanosulfonic acid-co-[2-(methacryloxy)ethyl]trimethylammonium chloride) (PAM) hydrogel matrix for controlled insulin release. We found that salecan not only tunes the structure and pore size of the PAM hydrogels, but also endows them with adjustable water release rates. More importantly, in vitro drug loading/release assays demonstrated that insulin is efficiently loaded into the resulting hydrogels and can be released in an on-demand manner by controlling the pH and salecan dose. Furthermore, cell viability and cell adhesion experiments verified the cell compatibility of these hydrogel carriers. Together, these results make salecan-incorporated PAM hydrogels promising materials for drug delivery.
authors.affiliation: Center for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing, 210094, China.
authors.forename: Xiaoliang
authors.identifier: 0000-0002-9703-9440
authors.initials: X
authors.lastname: Qi
authors.affiliation: Center for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing, 210094, China.
authors.forename: Junjian
authors.initials: J
authors.lastname: Li
authors.affiliation: Center for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing, 210094, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wei
authors.affiliation: Center for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing, 210094, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Su
authors.affiliation: Center for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing, 210094, China.
authors.forename: Gancheng
authors.initials: G
authors.lastname: Zuo
authors.affiliation: Center for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing, 210094, China.
authors.forename: Xihao
authors.initials: X
authors.lastname: Pan
authors.affiliation: Center for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing, 210094, China.
authors.forename: Jianfa
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Center for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing, 210094, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Dong
mesh_terms: D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D065546:Drug Liberation; D057809:HEK293 Cells; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D006863:Hydrogen-Ion Concentration; D007328:Insulin / Q000737:chemistry* / Q000378:metabolism; D008855:Microscopy, Electron, Scanning; D011108:Polymers / Q000737:chemistry*; D012212:Rheology; D017550:Spectroscopy, Fourier Transform Infrared; D013818:Thermogravimetry; D047071:beta-Glucans / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D007328:Insulin; D011108:Polymers; D047071:beta-Glucans; C577623:salecan; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate
keywords: drug delivery; hydrogels; insulin; polysaccharides; salecan