title: TMBIM-mediated Ca2+homeostasis and cell death.
abstract: Ca2+is a ubiquitous intracellular messenger that regulates numerous physiological activities in humans, animals, plants, and bacteria. Cytosolic Ca2+is kept at a low level, but subcellular organelles such as the endoplasmic reticulum (ER) and Golgi apparatus maintain high-concentration Ca2+stores. Under resting conditions, store Ca2+homeostasis is dynamically regulated to equilibrate between active Ca2+uptake and passive Ca2+leak processes. The evolutionarily conserved Transmembrane BAX Inhibitor-1 Motif-containing (TMBIM) proteins mediate Ca2+homeostasis and cell death. This review focuses on recent advances in functional and structural analysis of TMBIM proteins in regulation of the two related functions. The roles of TMBIM proteins in pathogen infection and cancer are also discussed with prospects for treatment. This article is part of a Special Issue entitled: ECS Meeting edited by Claus Heizmann, Joachim Krebs and Jacques Haiech.
authors.affiliation: Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA. Electronic address: qunliu@bnl.gov.
authors.forename: Qun
authors.initials: Q
authors.lastname: Liu
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D001426:Bacterial Proteins / Q000378:metabolism; D002118:Calcium / Q000502:physiology*; D006706:Homeostasis / Q000502:physiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D009369:Neoplasms / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000502:physiology*; D010940:Plant Proteins / Q000378:metabolism; D017386:Sequence Homology, Amino Acid
chemical_list: D001426:Bacterial Proteins; D009419:Nerve Tissue Proteins; D010940:Plant Proteins; D002118:Calcium
keywords: Apoptosis; Bax inhibitor-1; Ca(2+) channel structure; Ca(2+) homeostasis; Ca(2+) signaling; Cancer; Cell death; Cellular stress; Membrane proteins; TMBIM