title: Migraine Susceptibility Genes in Han Chinese of Fujian Province.
abstract: OBJECTIVE
  Five single-nucleotide polymorphisms (SNPs) (rs4379368, rs10504861, rs10915437, rs12134493 and rs13208321) were recently identified in a Western population with migraine. These migraine-associated SNPs have not been evaluated in a Han Chinese population. This study investigated the associations of specific SNPs with migraine in a Han population.
  
  
  METHODS
  This was a case-control study of Han Chinese residing in Fujian Province. Polymerase chain reaction-restriction-fragment-length polymorphism analysis and direct sequencing were used to characterize the relationships of SNPs in a control group of 200 subjects and in a migraine group of 201 patients.
  
  
  RESULTS
  The frequencies of the five SNPs did not differ between patients with migraine and healthy non migraine controls. However, subgroup analysis indicated certain SNPs were more strongly associated with migraine with aura or migraine without aura than with controls. The CT genotype of rs4379368 was more common in migraine patients with aura (75%) than in migraine patients without aura (47.9%) and controls (48.5%) (p<0.05), and the TT genotype of rs10504861 was more common in migraine patients with aura than in controls (8.3% vs. 0.5%) (p<0.05). Meanwhile, the CC genotype of rs12134493 was less common in migraine patients without aura than in controls (80.6% vs. 88%) (p<0.05).
  
  
  CONCLUSIONS
  Our findings suggest that the rs4379368 and rs10504861 SNPs are markers for susceptibility to migraine with aura and that rs12134493 is a marker for the risk of migraine without aura in this Han population. Future studies should further explore if these associations vary by ethnicity.
authors.affiliation: Department of Internal Neurology, Ningde Municipal Hospital, Fujian Medical University, Ningde, Fujian, China.
authors.forename: Qi Fang
authors.initials: QF
authors.lastname: Lin
authors.affiliation: Clinical Pharmacy, Ningde Municipal Hospital, Fujian Medical University, Ningde, Fujian, China.
authors.forename: Zi Chun
authors.initials: ZC
authors.lastname: Chen
authors.affiliation: Laboratory of Cell and Molecular Biology, Ningde Municipal Hospital, Fujian Medical University, Ningde, Fujian, China.
authors.forename: Xian Guo
authors.initials: XG
authors.lastname: Fu
authors.affiliation: Laboratory of Cell and Molecular Biology, Ningde Municipal Hospital, Fujian Medical University, Ningde, Fujian, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Yang
authors.affiliation: Laboratory of Cell and Molecular Biology, Ningde Municipal Hospital, Fujian Medical University, Ningde, Fujian, China.
authors.forename: Luo Yuan
authors.initials: LY
authors.lastname: Cao
authors.affiliation: Department of Internal Neurology, Ningde Municipal Hospital, Fujian Medical University, Ningde, Fujian, China.
authors.forename: Long Teng
authors.initials: LT
authors.lastname: Yao
authors.affiliation: Department of Internal Neurology, Ningde Municipal Hospital, Fujian Medical University, Ningde, Fujian, China.
authors.forename: Yong Tong
authors.initials: YT
authors.lastname: Xin
authors.affiliation: Department of Internal Neurology, Ningde Municipal Hospital, Fujian Medical University, Ningde, Fujian, China. genbinhuang@sina.com.
authors.forename: Gen Bin
authors.initials: GB
authors.lastname: Huang
keywords: aura; genotype; migraine; rs10504861; rs12134493; rs4379368; single-nucleotide polymorphism