title: Evaluation of the Anti-Inflammatory Effect of Locally Delivered Vitamin C in the Treatment of Persistent Gingival Inflammation: Clinical and Histopathological Study.
abstract: Objective. The purpose of this study is to investigate the role and efficiency of the locally injected vitamin C in the treatment of persistent gingival inflammation.Design. Twenty adult patients with persistent chronic gingival inflammation were included in this study. The same dose of sterile vitamin C was injected in gingival tissues after the completion of phase I therapy. Gingival biopsies were taken after total resolution of inflammation. The specimens were examined histologically, using H&E stain.Results. Clinical evaluation revealed great improvement of the injected sites with recall visits. Histopathological results revealed marked decrease in inflammatory cells and epithelial thickness and a higher number of newly formed subbasal capillaries.Conclusions. Vitamin C is an effective adjunctive treatment in reducing various degrees of chronic gingival inflammation.
authors.affiliation: National Institute of Laser Enhanced Sciences, Cairo University, Giza, Egypt.
authors.forename: Nermin M
authors.identifier: 0000-0002-7144-0156
authors.initials: NM
authors.lastname: Yussif
authors.affiliation: Oral Pathology Department, Faculty of Oral & Dental Medicine, Cairo University, Giza, Egypt.
authors.forename: Manar A
authors.initials: MA
authors.lastname: Abdul Aziz
authors.affiliation: Oral Diagnosis, Medicine & Periodontology Department, Faculty of Oral & Dental Medicine, Cairo University, Giza, Egypt.
authors.forename: Ahmed R
authors.initials: AR
authors.lastname: Abdel Rahman