title: Core/Shell Nanocomposites Produced by Superfast Sequential Microfluidic Nanoprecipitation.
abstract: Although a number of techniques exist for generating structured organic nanocomposites, it is still challenging to fabricate them in a controllable, yet universal and scalable manner. In this work, a microfluidic platform, exploiting superfast (milliseconds) time intervals between sequential nanoprecipitation processes, has been developed for high-throughput production of structured core/shell nanocomposites. The extremely short time interval between the sequential nanoprecipitation processes, facilitated by the multiplexed microfluidic design, allows us to solve the instability issues of nanocomposite cores without using any stabilizers. Beyond high throughput production rate (∼700 g/day on a single device), the generated core/shell nanocomposites harness the inherent ultrahigh drug loading degree and enhanced payload dissolution kinetics of drug nanocrystals and the controlled drug release from polymer-based nanoparticles.
authors.affiliation: Division of Pharmaceutical Chemistry and Technology, Drug Research Program, Faculty of Pharmacy, University of Helsinki , FI-00014 Helsinki, Finland.|John A. Paulson School of Engineering and Applied Sciences, Harvard University , Cambridge, Massachusetts 02138, United States.
authors.forename: Dongfei
authors.initials: D
authors.lastname: Liu
authors.affiliation: Division of Pharmaceutical Chemistry and Technology, Drug Research Program, Faculty of Pharmacy, University of Helsinki , FI-00014 Helsinki, Finland.|John A. Paulson School of Engineering and Applied Sciences, Harvard University , Cambridge, Massachusetts 02138, United States.
authors.forename: Hongbo
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Division of Pharmaceutical Chemistry and Technology, Drug Research Program, Faculty of Pharmacy, University of Helsinki , FI-00014 Helsinki, Finland.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Cito
authors.affiliation: Department of Orthopaedics, The First Affiliated Hospital of Nanjing Medical University , 210029 Nanjing, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Fan
authors.affiliation: Laboratory of Industrial Physics, Department of Physics and Astronomy, University of Turku , FI-20014 Turku, Finland.
authors.forename: Ermei
authors.identifier: 0000-0002-8300-6533
authors.initials: E
authors.lastname: Mäkilä
authors.affiliation: Laboratory of Industrial Physics, Department of Physics and Astronomy, University of Turku , FI-20014 Turku, Finland.
authors.forename: Jarno
authors.identifier: 0000-0002-5245-742X
authors.initials: J
authors.lastname: Salonen
authors.affiliation: Division of Pharmaceutical Chemistry and Technology, Drug Research Program, Faculty of Pharmacy, University of Helsinki , FI-00014 Helsinki, Finland.
authors.forename: Jouni
authors.initials: J
authors.lastname: Hirvonen
authors.affiliation: Division of Pharmaceutical Chemistry and Technology, Drug Research Program, Faculty of Pharmacy, University of Helsinki , FI-00014 Helsinki, Finland.
authors.forename: Tiina M
authors.identifier: 0000-0002-0788-1301
authors.initials: TM
authors.lastname: Sikanen
authors.affiliation: John A. Paulson School of Engineering and Applied Sciences, Harvard University , Cambridge, Massachusetts 02138, United States.
authors.forename: David A
authors.initials: DA
authors.lastname: Weitz
authors.affiliation: Division of Pharmaceutical Chemistry and Technology, Drug Research Program, Faculty of Pharmacy, University of Helsinki , FI-00014 Helsinki, Finland.
authors.forename: Hélder A
authors.identifier: 0000-0001-7850-6309
authors.initials: HA
authors.lastname: Santos
keywords: Sequential nanoprecipitation; core/shell; nanoparticles; stabilizer free; superfast