title: Effects of metabolic syndrome on aortic pulse wave velocity.
abstract: BACKGROUND
  The purpose of this study was to compare the value and evaluate the validity of non-invasive methods for the detection of vascular stiffness in never-treated individuals with metabolic syndrome (MetS).
  
  
  METHODS
  A total of 59 subjects (mean age, 60 ± 12 years; male:female = 35:24) were enrolled in the study and were categorized into the positive MetS (MetS[+]:N= 32) and negative group (MetS[-]:N= 27), according to the parameters set by the National Cholesterol Education Program's Adult Treatment Panel III. Pulse wave velocity (PWV) of the aorta, arm, and leg, Framingham risk score (FRS), ankle-brachial index (ABI), and carotid intima-media thickness (IMT) for vascular aging were measured for the two groups.
  
  
  RESULTS
  Aortic PWV (PWVaor) was significantly higher in MetS(+) than MetS(-) group (7.0 ± 1.4 m/s vs. 8.4 ± 1.6 m/s,p< 0.01), while ABI was significantly lower in MetS(+) than MetS(-) group (1.2 ± 0.1 vs. 1.1 ± 0.2,p= 0.03), respectively. FRS was significantly higher in MetS(+) than MetS(-) group (11 ± 5 vs. 14 ± 4,p= 0.05). The both mean IMT was higher in MetS(+) than MetS(-) group (right: 0.94 ± 0.20 mm vs. 0.81 ± 0.20 mm,p= 0.03; left: 0.93 ± 0.20 mm vs. 0.79 ± 0.20 mm,p= 0.03, respectively). For predicting the probability of the presence of MetS, PWVaorwas an independent tool (p= 0.04; odds ratio, 1.88; 95% confidence interval, 1.03 to 3.42) and a cut-off value of PWVaorof 7.4 m/s showed a sensitivity of 66.7% and a specificity of 47.6%.
  
  
  CONCLUSIONS
  We suggest that PWVaor, combined with traditional tools, can play an important role as a complementary or alternative tool for the detection of vascular stiffness in never-treated individuals with MetS.
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, #505 Banpo-dong, Seocho-gu, Seoul 137-701 South Korea.
authors.forename: Dong-Hyeon
authors.initials: DH
authors.lastname: Lee
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, #505 Banpo-dong, Seocho-gu, Seoul 137-701 South Korea.
authors.forename: Ho-Joong
authors.initials: HJ
authors.lastname: Youn
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, #505 Banpo-dong, Seocho-gu, Seoul 137-701 South Korea.
authors.forename: Woo-Baek
authors.initials: WB
authors.lastname: Chung
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, #505 Banpo-dong, Seocho-gu, Seoul 137-701 South Korea.
authors.forename: Yun-Seok
authors.initials: YS
authors.lastname: Choi
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, #505 Banpo-dong, Seocho-gu, Seoul 137-701 South Korea.
authors.forename: Jong-Min
authors.initials: JM
authors.lastname: Lee
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, #505 Banpo-dong, Seocho-gu, Seoul 137-701 South Korea.
authors.forename: Chul-Soo
authors.initials: CS
authors.lastname: Park
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, #505 Banpo-dong, Seocho-gu, Seoul 137-701 South Korea.
authors.forename: Hae-Ok
authors.initials: HO
authors.lastname: Jung
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, #505 Banpo-dong, Seocho-gu, Seoul 137-701 South Korea.
authors.forename: Hui-Kyung
authors.initials: HK
authors.lastname: Jeon
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, #505 Banpo-dong, Seocho-gu, Seoul 137-701 South Korea.
authors.forename: Man-Young
authors.initials: MY
authors.lastname: Lee
keywords: Aorta; Metabolic syndrome; Pulse wave velocity