title: The Impact of Mathematical Modeling in Understanding the Mechanisms Underlying Neurodegeneration: Evolving Dimensions and Future Directions.
abstract: Neurodegenerative diseases are a heterogeneous group of disorders that are characterized by the progressive dysfunction and loss of neurons. Here, we distil and discuss the current state of modeling in the area of neurodegeneration, and objectively compare the gaps between existing clinical knowledge and the mechanistic understanding of the major pathological processes implicated in neurodegenerative disorders. We also discuss new directions in the field of neurodegeneration that hold potential for furthering therapeutic interventions and strategies.
authors.affiliation: European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
authors.forename: A
authors.initials: A
authors.lastname: Lloret-Villas
authors.affiliation: European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
authors.forename: T M
authors.initials: TM
authors.lastname: Varusai
authors.affiliation: European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
authors.forename: N
authors.initials: N
authors.lastname: Juty
authors.affiliation: European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
authors.forename: C
authors.initials: C
authors.lastname: Laibe
authors.affiliation: Babraham Institute, Babraham Research Campus, Cambridge, UK.
authors.forename: N
authors.initials: N
authors.lastname: Le NovÈre
authors.affiliation: European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
authors.forename: H
authors.initials: H
authors.lastname: Hermjakob
authors.affiliation: European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
authors.forename: V
authors.initials: V
authors.lastname: Chelliah
mesh_terms: D000818:Animals; D006801:Humans; D008959:Models, Neurological; D019636:Neurodegenerative Diseases / Q000378:metabolism / Q000473:pathology*