title: Dietary total flavonoids intake and risk of mortality from all causes and cardiovascular disease in the general population: A systematic review and meta-analysis of cohort studies.
abstract: Epidemiologic studies assessing the association between dietary total flavonoids intake and the risk of mortality from cardiovascular disease (CVD) and all causes have yielded inconsistent results. Therefore, we conducted a dose-response meta-analysis to investigate this association.
  
  
  
  We searched PubMed and Embase databases from January 1966 through May 2016 and examined the references of retrieved articles to identify relevant prospective cohort studies. The random-effect model was used to calculate the summary risk estimates and dose-response analysis was performed. Ten studies were included in the present meta-analysis. The relative risk (RR) of all-cause mortality for the highest versus lowest category of total flavonoids intake was 0.82 (95% confidence interval (CI): 0.72-0.92). Dose-response analysis showed that those consuming 200 mg/day of total flavonoids had the lowest risk of all-cause mortality. Furthermore, a marginally significant association was found between dietary total flavonoids consumption and risk of death from CVD (summary RR: 0.85; 95% CI: 0.70-1.03; P = 0.099) and coronary heart diseases (summary RR: 0.74; 95% CI: 0.54-1.02; P = 0.069), respectively.
  
  
  
  The meta-analysis provides strong evidence for the recommendation of consuming flavonoids-rich food to reduce risks of mortality from all causes as part of a healthy diet among general adults.
authors.affiliation: School of Public Health, Wuhan University, Wuhan, China.|Zhongnan Hospital, Wuhan University, Wuhan, China.
authors.forename: Xue-Ming
authors.initials: XM
authors.lastname: Liu
authors.affiliation: School of Public Health, Wuhan University, Wuhan, China.
authors.forename: Yu-Jian
authors.initials: YJ
authors.lastname: Liu
authors.affiliation: School of Public Health, Wuhan University, Wuhan, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Huang
authors.affiliation: School of Public Health, Wuhan University, Wuhan, China.
authors.forename: Hong-Jie
authors.initials: HJ
authors.lastname: Yu
authors.affiliation: School of Public Health, Wuhan University, Wuhan, China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Yuan
authors.affiliation: School of Public Health, Wuhan University, Wuhan, China.
authors.forename: Bo-Wen
authors.initials: BW
authors.lastname: Tang
authors.affiliation: School of Public Health, Wuhan University, Wuhan, China.|Global Health Institute, Wuhan University, Wuhan, China.
authors.forename: Pei-Gang
authors.initials: PG
authors.lastname: Wang
authors.affiliation: School of Public Health, Wuhan University, Wuhan, China.|Global Health Institute, Wuhan University, Wuhan, China.
authors.forename: Qi-Qiang
authors.initials: QQ
authors.lastname: He
mesh_terms: D002318:Cardiovascular Diseases / Q000401:mortality* / Q000517:prevention & control*; D016208:Databases, Factual; D004032:Diet; D005419:Flavonoids / Q000008:administration & dosage*; D006801:Humans; D009026:Mortality; D012307:Risk Factors
chemical_list: D005419:Flavonoids
keywords: CVD; Flavonoids; Meta-analysis; Mortality; Prospective cohort study