title: Chemoselective Reactions for the Synthesis of Glycoconjugates from Unprotected Carbohydrates.
abstract: Glycobiology is the comprehensive biological investigation of carbohydrates. The study of the role and function of complex carbohydrates often requires the attachment of carbohydrates to surfaces, their tagging with fluorophores, or their conversion into natural or non-natural glycoconjugates, such as glycopeptides or glycolipids. Glycobiology and its "omics", glycomics, require easy and robust chemical methods for the construction of these glycoconjugates. This review gives an overview of the rapidly expanding field of chemical reactions that selectively convert unprotected carbohydrates into glycoconjugates through the anomeric position. The discussion is divided in terms of the anomeric bond type of the newly formed glycoconjugates, including O-, N-, S-, and C-glycosides.
authors.affiliation: Department of Chemistry, University of Copenhagen, Faculty of Science, Thorvaldsensvej 40, 1871, Frederiksberg C, Denmark.
authors.forename: Klaus
authors.identifier: 0000-0002-7569-0013
authors.initials: K
authors.lastname: Villadsen
authors.affiliation: Department of Chemistry, University of Copenhagen, Faculty of Science, Thorvaldsensvej 40, 1871, Frederiksberg C, Denmark.
authors.forename: Manuel C
authors.identifier: 0000-0002-4952-4329
authors.initials: MC
authors.lastname: Martos-Maldonado
authors.affiliation: Department of Chemistry, University of Copenhagen, Faculty of Science, Thorvaldsensvej 40, 1871, Frederiksberg C, Denmark.
authors.forename: Knud J
authors.identifier: 0000-0003-3525-5452
authors.initials: KJ
authors.lastname: Jensen
authors.affiliation: Department of Chemistry, University of Copenhagen, Faculty of Science, Thorvaldsensvej 40, 1871, Frederiksberg C, Denmark.
authors.forename: Mikkel B
authors.identifier: 0000-0002-0158-2802
authors.initials: MB
authors.lastname: Thygesen
mesh_terms: D060326:Chemistry Techniques, Synthetic; D006001:Glycoconjugates / Q000138:chemical synthesis*; D006031:Glycosylation; D009005:Monosaccharides / Q000737:chemistry*; D009844:Oligosaccharides / Q000737:chemistry*
chemical_list: D006001:Glycoconjugates; D009005:Monosaccharides; D009844:Oligosaccharides
keywords: carbohydrate-protein interactions; glycan tagging; glycobiology; glycoconjugates; glycoproteins