title: Moringa oleifera Lam. improves lipid metabolism during adipogenic differentiation of human stem cells.
abstract: Moringa oleifera Lam., a multipurpose tree, is used traditionally for its nutritional and medicinal properties. It has been used for the treatment of a variety of conditions, including inflammation, cancer and metabolic disorders.
  
  
  
  We investigated the effect of Moringa oleifera Lam. on adipogenic differentiation of human adipose-derived mesenchymal stem cells and its impact on lipid metabolism and cellular antioxidant systems.
  
  
  
  We showed that Moringa oleifera Lam. treatment during adipogenic differentiation reduces inflammation, lipid accumulation and induces thermogenesis by activation of uncoupling protein 1 (UCP1), sirtuin 1 (SIRT1), peroxisome proliferator-activated receptor alpha (PPARα), and coactivator 1 alpha (PGC1α). In addition, Moringa oleifera Lam. induces heme oxygenase-1 (HO-1), a well established protective and antioxidant enzyme. Finally Moringa oleifera Lam. significantly decreases the expression of molecules involved in adipogenesis and upregulates the expression of mediators involved in thermogenesis and lipid metabolism.
  
  
  
  Our results suggest that Moringa oleifera Lam. may promote the brown remodeling of white adipose tissue inducing thermogenesis and improving metabolic homeostasis.
authors.affiliation: Department of Drug Sciences, University of Catania, Catania, Italy. livolti@unict.it.
authors.forename: I
authors.initials: I
authors.lastname: Barbagallo
authors.forename: L
authors.initials: L
authors.lastname: Vanella
authors.forename: A
authors.initials: A
authors.lastname: Distefano
authors.forename: D
authors.initials: D
authors.lastname: Nicolosi
authors.forename: A
authors.initials: A
authors.lastname: Maravigna
authors.forename: G
authors.initials: G
authors.lastname: Lazzarino
authors.forename: M
authors.initials: M
authors.lastname: Di Rosa
authors.forename: D
authors.initials: D
authors.lastname: Tibullo
authors.forename: R
authors.initials: R
authors.lastname: Acquaviva
authors.forename: G
authors.initials: G
authors.lastname: Li Volti
mesh_terms: D000975:Antioxidants / Q000494:pharmacology; D002454:Cell Differentiation / Q000187:drug effects*; D051547:Heme Oxygenase-1; D006801:Humans; D050356:Lipid Metabolism / Q000187:drug effects*; D029588:Moringa oleifera; D010936:Plant Extracts / Q000494:pharmacology*; D013234:Stem Cells
chemical_list: D000975:Antioxidants; D010936:Plant Extracts; D051547:Heme Oxygenase-1