title: NHC-catalyzed [4 + 2] annulation of 2-bromo-2-enals with acylhydrazones: enantioselective synthesis of δ-lactams.
abstract: An asymmetric assembly of δ-lactams was realized via the NHC-catalyzed formal [4 + 2] annulation of acylhydrazones and 2-bromo-2-enals bearing γ-H. The advantages of this protocol include high enantioselectivity, good yields, mild reaction conditions and potential biological significance of the final products.
authors.affiliation: Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, School of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou 221116, P. R. China. csyao@jsnu.edu.cn.
authors.forename: Baomin
authors.initials: B
authors.lastname: Sun
authors.affiliation: Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, School of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou 221116, P. R. China. csyao@jsnu.edu.cn.
authors.forename: Lijiu
authors.initials: L
authors.lastname: Gao
authors.affiliation: Xuzhou Institute of Architectural Technology, Xuzhou, Jiangsu 221116, China.
authors.forename: Shide
authors.initials: S
authors.lastname: Shen
authors.affiliation: Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, School of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou 221116, P. R. China. csyao@jsnu.edu.cn.
authors.forename: Chenxia
authors.initials: C
authors.lastname: Yu
authors.affiliation: Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, School of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou 221116, P. R. China. csyao@jsnu.edu.cn.
authors.forename: Tuanjie
authors.initials: T
authors.lastname: Li
authors.affiliation: Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, School of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou 221116, P. R. China. csyao@jsnu.edu.cn.
authors.forename: Yuanwei
authors.initials: Y
authors.lastname: Xie
authors.affiliation: Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, School of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou 221116, P. R. China. csyao@jsnu.edu.cn.
authors.forename: Changsheng
authors.identifier: http://orcid.org/0000-0002-0185-2366
authors.initials: C
authors.lastname: Yao
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006835:Hydrazones / Q000737:chemistry*; D007769:Lactams / Q000138:chemical synthesis* / Q000737:chemistry; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D015394:Molecular Structure
chemical_list: C000601333:2-bromo-2-enal; D000447:Aldehydes; D006571:Heterocyclic Compounds; D006835:Hydrazones; D007769:Lactams; C030011:carbene; D008697:Methane