title: [Fatal interstitial lung disease associated with maximum androgen blockade].
abstract: Maximum androgen blockade is the standard endocrine treatment for advanced prostate cancer. Interstitial lung disease in different degrees of severity, with low mortality and excellent response to treatment may appear with its use. We report a 77 years old patient with advanced prostate cancer who developed severe and progressive respiratory failure associated to bilateral pulmonary infiltrates, attributed to the direct effect of maximum androgen blockade. Despite the therapeutic efforts, the patient died. Lung pathology revealed Usual Interstitial Pneumonia.
authors.affiliation: Unidad de Cuidados Intensivos, Hospital Británico de Buenos Aires, Argentina.
authors.forename: Guillermo
authors.initials: G
authors.lastname: Molina Mancero
authors.affiliation: Unidad de Cuidados Intensivos, Hospital Británico de Buenos Aires, Argentina.
authors.forename: Xavier
authors.initials: X
authors.lastname: Picón
authors.affiliation: Servicio de Neumonología, Hospital Británico de Buenos Aires, Argentina.
authors.forename: Fernando
authors.initials: F
authors.lastname: Di Tullio
authors.affiliation: Servicio de Neumonología, Hospital Británico de Buenos Aires, Argentina.
authors.forename: Glenda
authors.initials: G
authors.lastname: Ernst
authors.affiliation: Servicio de Histopatología, Hospital Británico de Buenos Aires, Argentina.
authors.forename: Pablo
authors.initials: P
authors.lastname: Dezanzo
authors.affiliation: Servicio de Neumonología, Hospital Británico de Buenos Aires, Argentina.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Salvado
authors.affiliation: Unidad de Cuidados Intensivos, Hospital Británico de Buenos Aires, Argentina.
authors.forename: Julio F
authors.initials: JF
authors.lastname: Chertcoff
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy; D000368:Aged; D000726:Androgen Antagonists / Q000009:adverse effects*; D000813:Anilides / Q000009:adverse effects; D000969:Antinematodal Agents / Q000009:adverse effects*; D001706:Biopsy; D018450:Disease Progression; D017809:Fatal Outcome; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D009570:Nitriles / Q000009:adverse effects; D011471:Prostatic Neoplasms / Q000188:drug therapy; D014057:Tomography, X-Ray Computed; D014105:Tosyl Compounds / Q000009:adverse effects
chemical_list: D000726:Androgen Antagonists; D000813:Anilides; D000969:Antinematodal Agents; D009570:Nitriles; D014105:Tosyl Compounds; C053541:bicalutamide