title: Pinnisterols D-J, New 11-Acetoxy-9,11-secosterols with a 1,4-Quinone Moiety from Formosan Gorgonian Coral Pinnigorgia sp. (Gorgoniidae).
abstract: Seven new marine 11-acetoxy-9,11-secosterols, pinnisterols D-J (1-7), with a 1,4-quinone moiety, were discovered from the gorgonian coralPinnigorgiasp. In this study, the structures of secosterols1-7were revealed by spectroscopic analysis. Bioactivity study showed that secosterol1treatment inhibited cell viability in a hepatic stellate cell line, HSC-T6, with an IC50value of 3.93 μM; and secosterols2,5, and7reduced elastase enzyme release, and3,5, and7decreased the production of superoxide anions from human neutrophils.
authors.affiliation: National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan. jay0404@gmail.com.|Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 804, Taiwan. jay0404@gmail.com.
authors.forename: Yu-Chia
authors.initials: YC
authors.lastname: Chang
authors.affiliation: Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan. htl@mail.cgu.edu.tw.|Research Center for Industry of Human Ecology, Research Center for Chinese Herbal Medicine, and Graduate Institute of Healthy Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan. htl@mail.cgu.edu.tw.|Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan. htl@mail.cgu.edu.tw.
authors.forename: Tsong-Long
authors.initials: TL
authors.lastname: Hwang
authors.affiliation: Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan. kuo33410@yahoo.com.tw.|Division of General Surgery, Department of Surgery, Chang Gung Memorial Hospital, Chiayi 613, Taiwan. kuo33410@yahoo.com.tw.
authors.forename: Liang-Mou
authors.initials: LM
authors.lastname: Kuo
authors.affiliation: National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan. pjsung@nmmba.gov.tw.|Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan. pjsung@nmmba.gov.tw.|Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan. pjsung@nmmba.gov.tw.|Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. pjsung@nmmba.gov.tw.|Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan. pjsung@nmmba.gov.tw.
authors.forename: Ping-Jyun
authors.initials: PJ
authors.lastname: Sung
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D016227:Benzoquinones / Q000737:chemistry* / Q000494:pharmacology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D055166:Hepatic Stellate Cells / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D013261:Sterols / Q000737:chemistry* / Q000494:pharmacology; D013481:Superoxides / Q000378:metabolism
chemical_list: D016227:Benzoquinones; D013261:Sterols; D013481:Superoxides; C004532:quinone
keywords: 9,11-secosterol; Pinnigorgia; anti-inflammatory; cytotoxicity; elastase; gorgonian; hepatic stellate cell line (HSC-T6); superoxide anion