title: Prognostic relevance of lactate dehydrogenase in advanced pancreatic ductal adenocarcinoma patients.
abstract: The prognostic role of pretreatment serum lactate dehydronegase (LDH) has been well established in many malignant tumors, albeit it remains under-discussed in pancreatic cancer. In the present study, we aimed to assess the association between baseline LDH levels and overall survival (OS) in advanced pancreatic ductal adenocarcinoma (PDAC) patients who did and did not receive subsequent chemotherapy.
  
  
  
  In total, 135 retrospectively determined patients with locally advanced or metastatic PDAC, who were diagnosed between 2012 and 2013, were analyzed. Baseline LDH levels were detected within 20 days after histopathological confirmation of the diagnosis. Multivariate Cox proportional hazards regression model was applied to estimate the adjusted hazards ratio (HR) for LDH levels and OS of PDAC. We used restricted cubic spline (RCS) to further investigate dose-effect relationship in the association.
  
  
  
  Having adjusted for possible confounders, we found that in advanced PDAC patients who went through subsequent chemotherapy, an elevated pretreatment LDH level (≥250 U/L) had an adjusted HR of 2.47 (95% CI = 1.28-4.77) for death, but patients, who did not receive chemotherapy, had no significant HR (adjusted HR = 1.57; 95% CI = 0.83-2.96). RCS fitting results revealed a steep increase in HR for PDAC patients received chemotherapy with a baseline LDH > 500 U/L.
  
  
  
  Pretreatment LDH levels had noticeable prognostic value in PDAC patients who received subsequent chemotherapy. Tackling elevated LDH levels before the initiation of chemotherapy might be a promising measure for improving OS of patients after treatment for their advanced PDAC. Studies with a large sample size and a prospective design are warranted to substantiate our findings.
authors.affiliation: Department of Biostatistics, School of Public Health, Fudan University, 130 Dong'an Road, Shanghai, China.|School of Public Health, Kunming Medical University, Kunming, Yunnan, China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Xiao
authors.affiliation: Information Center, Shanghai Municipal Commission of Health and Family Planning, Shanghai, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Chen
authors.affiliation: Information Center, Shanghai Municipal Commission of Health and Family Planning, Shanghai, China.
authors.forename: Zhihui
authors.initials: Z
authors.lastname: Xie
authors.affiliation: Information Center, Shanghai Municipal Commission of Health and Family Planning, Shanghai, China.
authors.forename: Zhenyi
authors.initials: Z
authors.lastname: Shao
authors.affiliation: Information Center, Shanghai Municipal Commission of Health and Family Planning, Shanghai, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Xie
authors.affiliation: Department of Biostatistics, School of Public Health, Fudan University, 130 Dong'an Road, Shanghai, China. gyqin@fudan.edu.cn.|Key Lab of Health Technology Assessment, Ministry of Health (Fudan University), Shanghai, China. gyqin@fudan.edu.cn.
authors.forename: Guoyou
authors.initials: G
authors.lastname: Qin
authors.affiliation: Department of Biostatistics, School of Public Health, Fudan University, 130 Dong'an Road, Shanghai, China. nqzhao1954@163.com.|Key Lab of Health Technology Assessment, Ministry of Health (Fudan University), Shanghai, China. nqzhao1954@163.com.
authors.forename: Naiqing
authors.initials: N
authors.lastname: Zhao
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D021441:Carcinoma, Pancreatic Ductal / Q000097:blood / Q000175:diagnosis* / Q000201:enzymology; D005260:Female; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000201:enzymology; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies
chemical_list: D014408:Biomarkers, Tumor; D007770:L-Lactate Dehydrogenase
keywords: Advanced pancreatic ductal adenocarcinoma; Lactate dehydrogenase; Restricted cubic spline; Survival analysis