title: [Local treatment of solitary intrapulmonary, malignant nodules].
abstract: BACKGROUND
  Intrapulmonary nodules generally represent an incidental finding in the roentgenogram or computed tomography (CT) scan of the chest. They are defined as single, well-circumscribed, radiographic opaque lesions that measures up to 3 cm in diameter and are surrounded completely by aerated lung. The probability of malignancy directly correlates with increasing diameter. Lesions that have a diameter of 1 cm or larger require direct evaluation.
  
  
  METHODS
  Surgery is the first option for patients with a malignant lesion, given an acceptable perioperative risk; for high-risk patients either radiofrequency ablation (RFA) or stereotactic body radiation therapy (SBRT) should be offered. In these cases the malignant histology has to be established beforehand or verified by radiologic proven growth.
  
  
  RESULTS
  Complete surgical resection is superior to RFA and SBRT with respect to local tumor control.
authors.affiliation: Abteilung Thoraxchirurgie, Thoraxklinik, Universitätsklinikum Heidelberg, Röntgenstraße 1, 69126, Heidelberg, Deutschland.
authors.forename: J
authors.initials: J
authors.lastname: Op den Winkel
authors.affiliation: Abteilung Thoraxchirurgie, Thoraxklinik, Universitätsklinikum Heidelberg, Röntgenstraße 1, 69126, Heidelberg, Deutschland.
authors.forename: F
authors.initials: F
authors.lastname: Eichhorn
authors.affiliation: Klinik für Strahlentherapie und Radioonkologie, Universitätsklinikum Heidelberg, 69120, Heidelberg, Deutschland.
authors.forename: S
authors.initials: S
authors.lastname: Rieken
authors.affiliation: Abteilung Thoraxchirurgie, Thoraxklinik, Universitätsklinikum Heidelberg, Röntgenstraße 1, 69126, Heidelberg, Deutschland. hendrik.dienemann@med.uni-heidelberg.de.|TLRC-H - Translational Lung Research Center Heidelberg, Heidelberg, Deutschland. hendrik.dienemann@med.uni-heidelberg.de.
authors.forename: H
authors.initials: H
authors.lastname: Dienemann
mesh_terms: D017115:Catheter Ablation / Q000379:methods*; D003131:Combined Modality Therapy / Q000379:methods; D019317:Evidence-Based Medicine; D006801:Humans; D018579:Patient Selection; D011013:Pneumonectomy / Q000379:methods*; D011379:Prognosis; D013902:Radiography, Thoracic / Q000379:methods; D016634:Radiosurgery / Q000379:methods*; D061089:Radiotherapy, Image-Guided / Q000379:methods; D003074:Solitary Pulmonary Nodule / Q000000981:diagnostic imaging* / Q000628:therapy*; D025321:Surgery, Computer-Assisted / Q000379:methods; D016896:Treatment Outcome
keywords: Cancer of the lung; Catheter ablation; Pulmonary coin lesion; Stereotactic body radiotherapy; Surgery