title: Epigenetic modification in chromatin machinery and its deregulation in pediatric brain tumors: Insight into epigenetic therapies.
abstract: Malignancies are characterized by the reprogramming of epigenetic patterns. This reprogramming includes gains or losses in DNA methylation and disruption of normal patterns of covalent histone modifications, which are associated with changes in chromatin remodeling processes. This review will focus on the mechanisms underlying this reprogramming and, specifically, on the role of histone modification in chromatin machinery and the modifications in epigenetic processes occurring in brain cancer, with a specific focus on epigenetic therapies for pediatric brain tumors.
authors.affiliation: a Department of Neurological Surgery , Northwestern University Feinberg School of Medicine , Chicago , IL , USA.|b Science in Society , Northwestern University , Evanston , IL , USA.
authors.forename: Eleonore
authors.initials: E
authors.lastname: Maury
authors.affiliation: a Department of Neurological Surgery , Northwestern University Feinberg School of Medicine , Chicago , IL , USA.|c Department of Biochemistry and Molecular Genetics , Northwestern University Feinberg School of Medicine , Chicago , IL , USA.
authors.forename: Rintaro
authors.initials: R
authors.lastname: Hashizume
mesh_terms: D000107:Acetylation; D001932:Brain Neoplasms / Q000235:genetics* / Q000628:therapy; D002648:Child; D002843:Chromatin / Q000235:genetics*; D019175:DNA Methylation / Q000235:genetics*; D044127:Epigenesis, Genetic; D006657:Histones / Q000235:genetics; D006801:Humans; D010372:Pediatrics
chemical_list: D002843:Chromatin; D006657:Histones
keywords: Acetylation; DIPG; brain tumor; demethylase; epigenetic; histone; methylation; methyltransferase; pediatric