title: Mild induced hypothermia for patients with severe traumatic brain injury after decompressive craniectomy.
abstract: To evaluate the efficacy and safety of mild induced hypothermia for intracranial hypertension in patients with traumatic brain injury after decompressive craniectomy.
  
  
  
  A total of 60 adults with intracranial pressure (ICP) of more than 20 mm Hg after decompressive craniectomy were randomly assigned to standard care (control group) or hypothermia (32°C-35°C) plus standard care. Then, ICP, cerebral perfusion pressure, Glasgow Outcome Scale score, and complications were assessed.
  
  
  
  There was a significant difference in ICP and cerebral perfusion pressure between the 2 groups. Favorable outcomes occurred in 12 (40.0%) and 7 (36.5%) patients in the hypothermia and control groups, respectively (P=.267). Kaplan-Meier curves revealed a marked difference in survival between the hypothermia and control groups (P=.032). There were significant differences in pulmonary infection and electrolyte disorders between the hypothermia and control groups (P=.038 and .033, respectively).
  
  
  
  Mild induced hypothermia can reduce intracranial hypertension after decompressive craniectomy, decreasing patient mortality. Hypothermia should be considered one of the main treatments for intracranial hypertension after decompressive craniectomy in patients with traumatic brain injury.
authors.affiliation: Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou City, Guangdong Province, China; Department of Neurosurgery, Tenth Affiliated Hospital, Guangxi Medical University, Guangdong Province, China.
authors.forename: Chunhai
authors.initials: C
authors.lastname: Tang
authors.affiliation: Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou City, Guangdong Province, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Bao
authors.affiliation: Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou City, Guangdong Province, China; First College of Clinical Medicine, Southern Medical University, Guangzhou City, Guangdong Province, China.
authors.forename: Min
authors.initials: M
authors.lastname: Qi
authors.affiliation: Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou City, Guangdong Province, China; Department of Biostatistics, school of biostatistics, Southern Medical University, Guangzhou City, Guangdong Province, China.
authors.forename: Lizhi
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou City, Guangdong Province, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Liu
authors.affiliation: Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou City, Guangdong Province, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Mao
authors.affiliation: Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou City, Guangdong Province, China; Department of Nursing, Nanfang Hospital, Southern Medical University, Guangzhou City, Guangdong Province, China.
authors.forename: Qingmei
authors.initials: Q
authors.lastname: Lei
authors.affiliation: Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou City, Guangdong Province, China. Electronic address: qisongtaonfyy@126.com.
authors.forename: Songtao
authors.initials: S
authors.lastname: Qi
authors.affiliation: Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou City, Guangdong Province, China.
authors.forename: Binghui
authors.initials: B
authors.lastname: Qiu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000070642:Brain Injuries, Traumatic / Q000150:complications* / Q000601:surgery*; D056424:Decompressive Craniectomy / Q000009:adverse effects*; D004311:Double-Blind Method; D005260:Female; D023261:Glasgow Outcome Scale; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods*; D019586:Intracranial Hypertension / Q000209:etiology; D007427:Intracranial Pressure; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011312:Pressure; D013696:Temperature; D016896:Treatment Outcome; D055815:Young Adult
keywords: Craniectomy; Hypothermia; Intracranial pressure; Outcome; Traumatic brain injury