title: Long-term Change of Subfoveal Choroidal Thickness in Behçet's Disease Patients with Posterior Uveitis.
abstract: OBJECTIVE
  To evaluate long-term changes of subfoveal choroidal thickness (SCT) in Behçet's disease (BD) patients with posterior uveitis.
  
  
  METHODS
  Changes in SCT measured with enhanced depth imaging optical coherence tomography during quiescent phase were assessed during >24 months in 63 BD patients and control group.
  
  
  RESULTS
  Baseline characteristics showed no difference, but the BD group showed poorer visual acuity (p = 0.013) and smaller SCT (p = 0.006) at final examination. Mean SCT in the BD group decreased from 291.0 to 268.1 μm (p<0.001) during the mean period of 38.5 months. Mean change rate of SCT in the BD group was greater than controls (-7.2 vs 2.0 μm/year; p<0.001) and was associated with longer active inflammation (p<0.001). Patients with longer disease duration showed smaller baseline SCT (p = 0.03).
  
  
  CONCLUSIONS
  In BD patients, choroidal thickness decreased over time, which was associated with length of active inflammation. It suggests intraocular inflammation in BD affects the choroid as well as the retina.
authors.affiliation: a Department of Ophthalmology , College of Medicine, Seoul National University , Seoul , Korea.
authors.forename: Un Chul
authors.initials: UC
authors.lastname: Park
authors.affiliation: a Department of Ophthalmology , College of Medicine, Seoul National University , Seoul , Korea.
authors.forename: In Hwan
authors.initials: IH
authors.lastname: Cho
authors.affiliation: b Department of Ophthalmology , Kyung Hee University School of Medicine , Seoul , Korea.
authors.forename: Sang Woong
authors.initials: SW
authors.lastname: Moon
authors.affiliation: a Department of Ophthalmology , College of Medicine, Seoul National University , Seoul , Korea.|c Sensory Organs Institute, Medical Research Center, Seoul National University , Seoul , Korea.
authors.forename: Hyeong Gon
authors.identifier: http://orcid.org/0000-0002-1795-202X
authors.initials: HG
authors.lastname: Yu
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D001528:Behcet Syndrome / Q000150:complications* / Q000175:diagnosis; D002829:Choroid / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D005584:Fovea Centralis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods; D015866:Uveitis, Posterior / Q000150:complications* / Q000175:diagnosis; D014792:Visual Acuity; D055815:Young Adult
keywords: Behçet’s disease; EDI-OCT; choroidal thickness; intraocular inflammation; posterior uveitis