title: Bioconjugation strategies to couple supramolecular exo-functionalized palladium cages to peptides for biomedical applications.
abstract: Supramolecular Pd2L4cages (L = ligand) hold promise as drug delivery systems. With the idea of achieving targeted delivery of the metallacages to tumor cells, the bioconjugation of exo-functionalized self-assembled Pd2L4cages to peptides following two different approaches is reported for the first time. The obtained bioconjugates were analyzed and identified by high-resolution mass spectrometry.
authors.affiliation: Department of Analytical Biochemistry, Groningen Research Institute of Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands. p.l.horvatovich@rug.nl and Dept. Pharmacokinetics, Toxicology and Targeting, Groningen Research Institute of Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: Han
authors.affiliation: Molecular Catalysis, Catalysis Research Center and Department of Chemistry, Technische Universität München, Lichtenbergstr. 4, 85747 Garching bei München, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Schmidt
authors.affiliation: Department of Analytical Biochemistry, Groningen Research Institute of Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands. p.l.horvatovich@rug.nl.
authors.forename: T
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Department of Analytical Biochemistry, Groningen Research Institute of Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands. p.l.horvatovich@rug.nl.
authors.forename: H
authors.initials: H
authors.lastname: Permentier
authors.affiliation: Dept. Pharmacokinetics, Toxicology and Targeting, Groningen Research Institute of Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.
authors.forename: G M M
authors.initials: GM
authors.lastname: Groothuis
authors.affiliation: Department of Analytical Biochemistry, Groningen Research Institute of Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands. p.l.horvatovich@rug.nl.
authors.forename: R
authors.initials: R
authors.lastname: Bischoff
authors.affiliation: Molecular Catalysis, Catalysis Research Center and Department of Chemistry, Technische Universität München, Lichtenbergstr. 4, 85747 Garching bei München, Germany.
authors.forename: F E
authors.identifier: http://orcid.org/0000-0002-4156-780X
authors.initials: FE
authors.lastname: Kühn
authors.affiliation: Department of Analytical Biochemistry, Groningen Research Institute of Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands. p.l.horvatovich@rug.nl.
authors.forename: P
authors.initials: P
authors.lastname: Horvatovich
authors.affiliation: Dept. Pharmacokinetics, Toxicology and Targeting, Groningen Research Institute of Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands and School of Chemistry, Cardiff University, Park Place, CF103AT Cardiff, UK. casinia@cardiff.ac.uk.
authors.forename: A
authors.identifier: http://orcid.org/0000-0003-1599-9542
authors.initials: A
authors.lastname: Casini
mesh_terms: D035843:Biomedical Research; D016503:Drug Delivery Systems; D046911:Macromolecular Substances / Q000737:chemistry; D013058:Mass Spectrometry; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*
chemical_list: D046911:Macromolecular Substances; D009942:Organometallic Compounds; D010455:Peptides; D010165:Palladium