title: [Proton pump inhibitor - side effects and complications of long-term proton pump inhibitor administration].
abstract: Proton Pump Inhibitors are among the most common drugs taken. The indication is for treatment of heartburn, reflux disease, prophylaxis and treatment of peptic ulcers, in combination with NSAIDs and steroids as well as H. pylori-eradication. PPI's are widely used, even with non-specific symptoms. This certainly has to do with good tolerability and a previously considered low side effect profile. At the moment, there is growing evidence that the long-term intake of PPI's may not be as safe as assumed. In addition to interactions with some drugs, including platelet aggregation inhibitors, recent studies have shown an increased risk of myocardial infarction, interstitial nephritis, chronic renal injury, infections, vitamin deficiencies and electrolyte shifts as well developing dementia.
authors.forename: Hendrik
authors.initials: H
authors.lastname: Ueberschaer
authors.forename: Hans-Dieter
authors.initials: HD
authors.lastname: Allescher
mesh_terms: D001361:Avitaminosis / Q000139:chemically induced* / Q000517:prevention & control; D003704:Dementia / Q000139:chemically induced* / Q000517:prevention & control; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D019317:Evidence-Based Medicine; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced* / Q000517:prevention & control; D009203:Myocardial Infarction / Q000139:chemically induced* / Q000517:prevention & control; D054328:Proton Pump Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects*; D012307:Risk Factors; D016896:Treatment Outcome; D014883:Water-Electrolyte Imbalance / Q000139:chemically induced* / Q000517:prevention & control
chemical_list: D054328:Proton Pump Inhibitors