title: Improving the throughput of batch photochemical reactions using flow: Dual photoredox and nickel catalysis in flow for C(sp2)C(sp3) cross-coupling.
abstract: We report herein the transfer of dual photoredox and nickel catalysis for C(sp2)C(sp3) cross coupling form batch to flow. This new procedure clearly improves the scalability of the previous batch reaction by the reactor's size and operating time reduction, and allows the preparation of interesting compounds for drug discovery in multigram amounts.
authors.affiliation: Janssen Research and Development, Janssen-Cilag, S.A., C/Jarama 75, 45007 Toledo, Spain.
authors.forename: Irini
authors.initials: I
authors.lastname: Abdiaj
authors.affiliation: Janssen Research and Development, Janssen-Cilag, S.A., C/Jarama 75, 45007 Toledo, Spain. Electronic address: jalcazar@its.jnj.com.
authors.forename: Jesús
authors.initials: J
authors.lastname: Alcázar
mesh_terms: D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D008027:Light; D009532:Nickel / Q000737:chemistry*; D010084:Oxidation-Reduction; D055668:Photochemical Processes; D011789:Quantum Theory
chemical_list: D002244:Carbon; D009532:Nickel
keywords: C(sp(2))C(sp(3)) cross-coupling; Dual catalysis; Flow chemistry; Medicinal chemistry; Photoredox