title: The effect of glyphosate-based herbicide Roundup and its co-formulant, POEA, on the motoric activity of rat intestine - In vitro study.
abstract: The study was aimed at evaluating the effect of Roundup, polyoxyethylene tallow amine (POEA) and mixture of glyphosate and POEA in different levels on the motoric activity of jejunum strips. The incubation in the Roundup solutions caused a significant, mostly miorelaxant, reversible reaction of smooth muscle; only in the highest tested dose which is equivalent to the agricultural concentration (1% corresponding to 1.7g glyphosate/L) there was an irreversible disturbance of the spontaneous contractility and reactivity. The incubation in POEA solutions in the range of low doses (0.256; 1.28; 6.4mg/L) resulted in a biphasic muscle reaction (relaxation and contraction); whereas in the range of high doses, i.e. 32; 160 and 800mg/L (agricultural spray concentrations) induced only a miorelaxant, irreversible response. The results indicate very high toxicity of POEA which exceeds the toxicity of the commercial formulations. Besides, it is postulated that glyphosate and POEA may display antagonistic interaction towards the motoric activity of gastrointestinal tract.
authors.affiliation: Warsaw University of Life Sciences, Faculty of Veterinary Medicine, Department of Preclinical Sciences, Division of Pharmacology and Toxicology, 8, Ciszewskiego St.,02-786 Warsaw, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Chłopecka
authors.affiliation: Warsaw University of Life Sciences, Faculty of Veterinary Medicine, Department of Preclinical Sciences, Division of Pharmacology and Toxicology, 8, Ciszewskiego St.,02-786 Warsaw, Poland. Electronic address: marta_mendel@sggw.pl.
authors.forename: Marta
authors.initials: M
authors.lastname: Mendel
authors.affiliation: Warsaw University of Life Sciences, Faculty of Veterinary Medicine, Department of Preclinical Sciences, Division of Pharmacology and Toxicology, 8, Ciszewskiego St.,02-786 Warsaw, Poland.
authors.forename: Natalia
authors.initials: N
authors.lastname: Dziekan
authors.affiliation: Warsaw University of Life Sciences, Faculty of Veterinary Medicine, Department of Preclinical Sciences, Division of Pharmacology and Toxicology, 8, Ciszewskiego St.,02-786 Warsaw, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Karlik
mesh_terms: D000818:Animals; D005998:Glycine / Q000031:analogs & derivatives* / Q000633:toxicity; D006540:Herbicides / Q000633:toxicity*; D007583:Jejunum / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D011092:Polyethylene Glycols / Q000633:toxicity*; D017208:Rats, Wistar; D000097797:Glyphosate
chemical_list: D005998:Glycine; D006540:Herbicides; D011092:Polyethylene Glycols; D000097797:Glyphosate; C054694:polyoxyethyleneamine
keywords: Glyphosate; Interaction; Jejunum strips; Motoric activity; POEA; Roundup