title: Enhanced pH stability, cell viability and reduced degradation rate of poly(L-lactide)-based composite in vitro: effect of modified magnesium oxide nanoparticles.
abstract: The modified MgO nanoparticles (m-MgO-NPs) by a copolymer containing the malic acid and low molecular weight poly(L-lactide) (poly(L-lactide-co-malic acid), PLMA) have been successfully prepared. MgO nanoparticles (MgO-NPs) were coated by the PLMA and m-MgO-NPs were uniformly dispersed in the PLLA matrix to a novel biocomposite material (PLLA/m-MgO-NPs) with more excellent interface bonding and uniformer dispersion, compared to the PLLA/MgO-NPs. Compared to neat PLLA and PLLA/MgO-NPs film, the m-MgO-NPs not only shown the obvious neutralization effect on the acidic solution in the degradation of the PLLA and better hydrophilicity, but also exhibited the higher cell viability and decrease the toxicity to the cell in the degradation process of PLLA in vitro. In addition, m-MgO-NPs also reduced the degradation rate of the PLLA. The mechanisms for the excellent dispersion of nanoparticles, enhanced pH stability, reduced degradation rate of the PLLA and the cell viability in vitro in the case of PLLA/m-MgO-NPs have also been proposed and discussed in detail.
authors.affiliation: a School of Materials Science and Engineering , Tianjin University of Technology , Tianjin , China.|b School of Environmental Science and Safety Engineering , Tianjin University of Technology , Tianjin , China.
authors.forename: Jinjun
authors.initials: J
authors.lastname: Yang
authors.affiliation: a School of Materials Science and Engineering , Tianjin University of Technology , Tianjin , China.
authors.forename: Xiuxiang
authors.initials: X
authors.lastname: Cao
authors.affiliation: a School of Materials Science and Engineering , Tianjin University of Technology , Tianjin , China.|c Tianjin Key Lab for Photoelectric Materials & Devices , Tianjin , China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: c Tianjin Key Lab for Photoelectric Materials & Devices , Tianjin , China.
authors.forename: Liang
authors.initials: L
authors.lastname: Wang
authors.affiliation: a School of Materials Science and Engineering , Tianjin University of Technology , Tianjin , China.
authors.forename: Bei
authors.initials: B
authors.lastname: Liu
authors.affiliation: a School of Materials Science and Engineering , Tianjin University of Technology , Tianjin , China.
authors.forename: Junping
authors.initials: J
authors.lastname: Jia
authors.affiliation: a School of Materials Science and Engineering , Tianjin University of Technology , Tianjin , China.
authors.forename: Hui
authors.initials: H
authors.lastname: Liang
authors.affiliation: a School of Materials Science and Engineering , Tianjin University of Technology , Tianjin , China.|c Tianjin Key Lab for Photoelectric Materials & Devices , Tianjin , China.
authors.forename: Minfang
authors.initials: M
authors.lastname: Chen
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004355:Drug Stability; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008277:Magnesium Oxide / Q000737:chemistry* / Q000633:toxicity; D008293:Malates / Q000737:chemistry; D051379:Mice; D008970:Molecular Weight; D053761:Nanocomposites / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D011091:Polyesters / Q000737:chemistry* / Q000633:toxicity; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D008293:Malates; D011091:Polyesters; D008277:Magnesium Oxide; C033616:poly(lactide); C030298:malic acid
keywords: Poly(L-lactide); in vitro; magnesium oxide nanoparticle; modification