title: Alzheimer's Disease and Natural Products: Future Regimens Emerging from Nature.
abstract: Alzheimer's disease (AD), which largely affects the elderly, has become a global burden. Patients with AD have both short- and long-term memory impairments. The neuronal loss in AD occurs due to abnormally folded amyloid beta proteins and aggregation of hyperphosphorylated tau proteins in the brain. Eventually, amyloid plaques and neurofibrillary tangles are formed, which subsequently disintegrate the neuronal transport system. There are several factors which are involved in AD pathogenesis, including oxidative stress, inflammation and the presence of metal ions. The modern therapies utilized for AD treatment have many adverse effects, driving the quest for more safe and effective medications. Many dietary components, including different types of fruits, vegetables, spices, and marine products as well as a Mediterranean diet, are a good source of antioxidants and have anti-inflammatory properties, with many showing substantial potential against AD pathogenesis. In this review, we discuss the potential of these foods for treating AD and opportunities for developing disease-targeted drugs from active compounds extracted from natural dietary products.
authors.affiliation: Human Genome Centre, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan. Malaysia.
authors.forename: Md Asiful
authors.initials: MA
authors.lastname: Islam
authors.affiliation: Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka-1342. Bangladesh.
authors.forename: Shahad Saif
authors.initials: SS
authors.lastname: Khandker
authors.affiliation: Human Genome Centre, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan. Malaysia.
authors.forename: Fahmida
authors.initials: F
authors.lastname: Alam
authors.affiliation: Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka-1342. Bangladesh.|Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh.
authors.forename: Md Ibrahim
authors.initials: MI
authors.lastname: Khalil
authors.affiliation: King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.|Enzymoics, 7 Peterlee Place, Hebersham, NSW 2770, Australia.|Novel Global Community Educational Foundation, Australia.
authors.forename: Mohammad Amjad
authors.initials: MA
authors.lastname: Kamal
authors.affiliation: Human Genome Centre, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan. Malaysia.
authors.forename: Siew Hua
authors.initials: SH
authors.lastname: Gan
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000378:metabolism; D000975:Antioxidants / Q000009:adverse effects / Q000302:isolation & purification / Q000494:pharmacology*; D001688:Biological Products / Q000009:adverse effects / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans
chemical_list: D000975:Antioxidants; D001688:Biological Products
keywords: Alzheimer's disease; Drinks; Fruits; Mediterranean diet; Natural products; Spices; Treatment; Vegetables