title: CDPKs and 14-3-3 Proteins: Emerging Duo in Signaling.
abstract: Calcium-dependent protein kinases (CDPKs) are Ca2+-sensors that play pivotal roles in plant development and stress responses. They have the unique ability to directly translate intracellular Ca2+signals into reversible phosphorylation events of diverse substrates which can mediate interactions with 14-3-3 proteins to modulate protein functions. Recent studies have revealed roles for the coordinated action of CDPKs and 14-3-3s in regulating diverse aspects of plant biology including metabolism, development, and stress responses. We review here the underlying interaction and cross-regulation of the two signaling proteins, and we discuss how this insight has led to the emerging concept of CDPK/14-3-3 signaling modules that could contribute to response specificity.
authors.affiliation: Laboratoire de Recherche en Sciences Végétales, Université de Toulouse, CNRS, UPS, 24 chemin de Borde Rouge, Auzeville, BP 42617, 31326 Castanet Tolosan, France.
authors.forename: Mélanie
authors.initials: M
authors.lastname: Ormancey
authors.affiliation: Laboratoire de Recherche en Sciences Végétales, Université de Toulouse, CNRS, UPS, 24 chemin de Borde Rouge, Auzeville, BP 42617, 31326 Castanet Tolosan, France.
authors.forename: Patrice
authors.initials: P
authors.lastname: Thuleau
authors.affiliation: Laboratoire de Recherche en Sciences Végétales, Université de Toulouse, CNRS, UPS, 24 chemin de Borde Rouge, Auzeville, BP 42617, 31326 Castanet Tolosan, France.
authors.forename: Christian
authors.initials: C
authors.lastname: Mazars
authors.affiliation: Laboratoire de Recherche en Sciences Végétales, Université de Toulouse, CNRS, UPS, 24 chemin de Borde Rouge, Auzeville, BP 42617, 31326 Castanet Tolosan, France. Electronic address: cotelle@lrsv.ups-tlse.fr.
authors.forename: Valérie
authors.initials: V
authors.lastname: Cotelle
mesh_terms: D048948:14-3-3 Proteins / Q000235:genetics / Q000378:metabolism*; D018506:Gene Expression Regulation, Plant / Q000235:genetics / Q000502:physiology; D010940:Plant Proteins / Q000235:genetics / Q000378:metabolism; D011494:Protein Kinases / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology; D017871:Calcium-Calmodulin-Dependent Protein Kinases
chemical_list: D048948:14-3-3 Proteins; D010940:Plant Proteins; D011494:Protein Kinases; D017871:Calcium-Calmodulin-Dependent Protein Kinases
keywords: 14-3-3 proteins; CDPK; calcium signaling; protein phosphorylation; protein–protein interaction; signal transduction