title: Immunity to Commensal Fungi: Detente and Disease.
abstract: Fungi are ubiquitous in our environment, and a healthy immune system is essential to maintain adequate protection from fungal infections. When this protection breaks down, superficial and invasive fungal infections cause diseases that range from irritating to life-threatening. Millions of people worldwide develop invasive infections during their lives, and mortality for these infections often exceeds 50%. Nevertheless, we are normally colonized with many of the same disease-causing fungi (e.g., on the skin or in the gut). Recent research is dramatically expanding our understanding of the mechanisms by which our immune systems interact with these organisms in health and disease. In this review, we discuss what is currently known about where and how the immune system interacts with common fungi.
authors.affiliation: F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, and Division of Immunology, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California 90048; email: David.Underhill@csmc.edu , Matthew.Wheeler@cshs.org , Jose.Limon-Tello@cshs.org.
authors.forename: Matthew L
authors.initials: ML
authors.lastname: Wheeler
authors.affiliation: F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, and Division of Immunology, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California 90048; email: David.Underhill@csmc.edu , Matthew.Wheeler@cshs.org , Jose.Limon-Tello@cshs.org.
authors.forename: Jose J
authors.initials: JJ
authors.lastname: Limon
authors.affiliation: F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, and Division of Immunology, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California 90048; email: David.Underhill@csmc.edu , Matthew.Wheeler@cshs.org , Jose.Limon-Tello@cshs.org.|Centre of Molecular Inflammation Research, Norwegian University of Science and Technology, 7491 Trondheim, Norway.
authors.forename: David M
authors.initials: DM
authors.lastname: Underhill
mesh_terms: D056704:Adaptive Immunity / Q000276:immunology*; D000818:Animals; D004194:Disease / Q000209:etiology*; D005658:Fungi / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D009181:Mycoses / Q000150:complications* / Q000276:immunology*
keywords: Aspergillus; Candida; Dectin-1; Malassezia; innate immunity; microbiome; mycobiome