title: Nonobese Diabetic (NOD) Mice Lack a Protective B-Cell Response against the "Nonlethal"Plasmodium yoelii17XNL Malaria Protozoan.
abstract: Background.Plasmodium yoelii17XNL is a nonlethal malaria strain in mice of different genetic backgrounds including the C57BL/6 mice (I-Ab/I-Enull) used in this study as a control strain. We have compared the trends of blood stage infection with the nonlethal murine strain ofP. yoelii17XNL malaria protozoan in immunocompetent Nonobese Diabetic (NOD) mice prone to type 1 diabetes (T1D) and C57BL/6 mice (control mice) that are not prone to T1D andself-cure theP. yoelii17XNL infection. Prediabetic NOD mice could not mount a protective antibody response to theP. yoelii17XNL-infected red blood cells (iRBCs), and they all succumbed shortly after infection. Our data suggest that the lack of anti-P. yoelii17XNL-iRBCs protective antibodies in NOD mice is a result of parasite-induced, Foxp3+T regulatory (Treg) cells able to suppress the parasite-specific antibody secretion.Conclusions. The NOD mouse model may help in identifying new mechanisms of B-cell evasion by malaria parasites. It may also serve as a more accurate tool for testing antimalaria therapeutics due to the lack of interference with a preexistentself-curing mechanism present in other mouse strains.
authors.affiliation: Department of Medicine, Division of Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
authors.forename: Mirian
authors.initials: M
authors.lastname: Mendoza
authors.affiliation: Department of Medicine, Division of Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA; Benaroya Research Institute at Virginia Mason, 1201 Ninth Avenue, Seattle, WA 98101, USA.
authors.forename: Luis
authors.identifier: 0000-0002-5367-3722
authors.initials: L
authors.lastname: Pow Sang
authors.affiliation: Department of Medicine, Division of Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
authors.forename: Qi
authors.initials: Q
authors.lastname: Qiu
authors.affiliation: Department of Medicine, Division of Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA; Infectious Diseases Directorate, Division of Malaria, Naval Medical Research Center/Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
authors.forename: Sofia
authors.initials: S
authors.lastname: Casares
authors.affiliation: Department of Medicine, Division of Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
authors.forename: Teodor-D
authors.identifier: 0000-0002-1112-7643
authors.initials: TD
authors.lastname: Brumeanu