title: LncRNAs and miRNAs: potential biomarkers and therapeutic targets for prostate cancer.
abstract: Prostate cancer (PCa) is the second lethal disease for men in western countries. Although androgen receptor (AR) signaling has been widely investigated, noncoding RNAs (ncRNAs), deficient of open reading frame, have also received considerable attention. Growing studies showed that the aberrant ncRNAs expression contributed to cell proliferation, metastasis and drug resistance in PCa. Therefore, therapeutically targeting ncRNAs may synergize androgen deprivation therapy (ADT) to have a better effect to fight against PCa, especially castration-resistant prostate cancer (CRPC). This review would systematically summarize the multicellular events controlled by ncRNAs and give a snapshot of future scientific activities and clinical applications.
authors.affiliation: Engineering Research Center of Molecular Medicine, Ministry of Education, China & School of Biomedical Sciences, Huaqiao UniversityXiamen, China; Key Laboratory of Xiamen Marine and Gene DrugsXiamen, China; Key Laboratory of Fujian Molecular MedicineXiamen 361021, China.
authors.forename: Guoxing
authors.initials: G
authors.lastname: Ma
authors.affiliation: Engineering Research Center of Molecular Medicine, Ministry of Education, China & School of Biomedical Sciences, Huaqiao UniversityXiamen, China; Key Laboratory of Fujian Molecular MedicineXiamen 361021, China.
authors.forename: Mingqing
authors.initials: M
authors.lastname: Tang
authors.affiliation: Engineering Research Center of Molecular Medicine, Ministry of Education, China & School of Biomedical Sciences, Huaqiao UniversityXiamen, China; Key Laboratory of Xiamen Marine and Gene DrugsXiamen, China.
authors.forename: Yaqing
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Engineering Research Center of Molecular Medicine, Ministry of Education, China & School of Biomedical Sciences, Huaqiao University Xiamen, China.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Xu
authors.affiliation: Engineering Research Center of Molecular Medicine, Ministry of Education, China & School of Biomedical Sciences, Huaqiao University Xiamen, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Pan
authors.affiliation: Engineering Research Center of Molecular Medicine, Ministry of Education, China & School of Biomedical Sciences, Huaqiao UniversityXiamen, China; Key Laboratory of Xiamen Marine and Gene DrugsXiamen, China; Key Laboratory of Fujian Molecular MedicineXiamen 361021, China.
authors.forename: Ruian
authors.initials: R
authors.lastname: Xu
keywords: Prostate cancer; diagnosis; lncRNA; miRNA; therapeutic target