title: Type I DNA Topoisomerases.
abstract: DNA topoisomerases constitute a large family of enzymes that are essential for all domains of life. Although they share general reaction chemistry and the capacity to govern DNA topology and resolve strand entanglements during fundamental molecular processes, they are characterized by differences in their structural organization, modes of enzymatic catalysis, and biological functions. Moreover, hundreds of compounds interfere with bacterial and/or eukaryotic enzymes, some of which are effective drugs for the treatment of infectious diseases and cancers. Research over the past decade has focused on the biological functions of DNA topoisomerases, and several findings have revealed unexpected roles of type I DNA topoisomerases, a subclass of these enzymes, in regulating gene expression and DNA and chromatin conformations. These new findings highlight that type I topoisomerases are still interesting targets for drug discovery for the treatment of several human diseases, including multidrug-resistant infections and genetic disorders.
authors.affiliation: Department of Pharmacy and Biotechnology, University of Bologna , Via Belmeloro 8/2, 40126 Bologna, Italy.
authors.forename: Giovanni
authors.identifier: 0000-0002-8708-6454
authors.initials: G
authors.lastname: Capranico
authors.affiliation: Department of Pharmacy and Biotechnology, University of Bologna , Via Belmeloro 8/2, 40126 Bologna, Italy.
authors.forename: Jessica
authors.initials: J
authors.lastname: Marinello
authors.affiliation: SCAI SuperComputing Applications and Innovation Department, Cineca , Via dei Tizii 6, 00185 Rome, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Chillemi
mesh_terms: D000818:Animals; D004247:DNA / Q000235:genetics / Q000378:metabolism; D004264:DNA Topoisomerases, Type I / Q000737:chemistry / Q000378:metabolism*; D055808:Drug Discovery; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D008958:Models, Molecular; D059004:Topoisomerase I Inhibitors / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D059004:Topoisomerase I Inhibitors; D004247:DNA; D004264:DNA Topoisomerases, Type I