title: From Micro to Macro: The Hierarchical Design in a Micropatterned Scaffold for Cell Assembling and Transplantation.
abstract: A microwell-patterned membranous scaffold that integrates nano- and microscale topographical characteristics based on polyurethane is fabricated for transplanting syngeneic islets and allogeneic mesenchymal stem cells into diabetic rodents. The scaffold effectively allows for assembling of single cells/microtissues, enables the transplantation of cells with spatial control, and improves the transplant's engraftment efficacy in vivo for treating diabetes.
authors.affiliation: Department of Biomedical Engineering, Peking University, Beijing, 100871, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Wang
authors.affiliation: Department of Biomedical Engineering, Peking University, Beijing, 100871, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Wang
authors.affiliation: Institute of Molecular Medicine, Peking University, Beijing, 100871, China.
authors.forename: Chengsheng
authors.initials: C
authors.lastname: Han
authors.affiliation: Department of Biomedical Engineering, Peking University, Beijing, 100871, China.
authors.forename: Wenda
authors.initials: W
authors.lastname: Hou
authors.affiliation: Department of Biomedical Engineering, Peking University, Beijing, 100871, China.
authors.forename: Jinyang
authors.initials: J
authors.lastname: Wang
authors.affiliation: Institute of Molecular Medicine, Peking University, Beijing, 100871, China.
authors.forename: Liangyi
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Biomedical Engineering, Peking University, Beijing, 100871, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Luo
mesh_terms: D002478:Cells, Cultured; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells; D054457:Tissue Scaffolds
keywords: diabetes; islets; mesenchymal stem cells; microwells; nanofibers