title: Baseline Cardiovascular Characteristics of Adult Patients with Chronic Kidney Disease from the KoreaN Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD).
abstract: Cardiovascular disease (CVD) is the most common cause of death in patients with chronic kidney disease (CKD). We report the baseline cardiovascular characteristics of 2,238 participants by using the data of the KoreaN Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD) study. The cohort comprises 5 subcohorts according to the cause of CKD: glomerulonephritis (GN), diabetic nephropathy (DN), hypertensive nephropathy (HTN), polycystic kidney disease (PKD), and unclassified. The average estimated glomerular filtration rate (eGFR) was 50.5 ± 30.3 mL/min⁻¹/1.73 m⁻² and lowest in the DN subcohort. The overall prevalence of previous CVD was 14.4% in all patients, and was highest in the DN followed by that in the HTN subcohort. The DN subcohort had more adverse cardiovascular risk profiles (higher systolic blood pressure [SBP], and higher levels of cardiac troponin T, left ventricular mass index [LVMI], coronary calcium score, and brachial-ankle pulse wave velocity [baPWV]) than the other subcohorts. The HTN subcohort exhibited less severe cardiovascular risk profiles than the DN subcohort, but had more severe cardiovascular risk features than the GN and PKD subcohorts. All these cardiovascular risk profiles were inversely correlated with eGFR. In conclusion, this study shows that the KNOW-CKD cohort exhibits high cardiovascular burden, as other CKD cohorts in previous studies. Among the subcohorts, the DN subcohort had the highest risk for CVD. The ongoing long-term follow-up study up to 10 years will further delineate cardiovascular characteristics and outcomes of each subcohort exposed to different risk profiles.
authors.affiliation: Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Hyoungnae
authors.identifier: http://orcid.org/0000-0002-5359-0214
authors.initials: H
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Tae Hyun
authors.identifier: http://orcid.org/0000-0002-9183-4507
authors.initials: TH
authors.lastname: Yoo
authors.affiliation: Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Kyu Hun
authors.identifier: http://orcid.org/0000-0003-0095-9011
authors.initials: KH
authors.lastname: Choi
authors.affiliation: Department of Internal Medicine, Seoul National University, Seoul, Korea.
authors.forename: Kook Hwan
authors.identifier: http://orcid.org/0000-0001-9525-2179
authors.initials: KH
authors.lastname: Oh
authors.affiliation: Medical Research Collaborating Center, Seoul National University Hospital and Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Joongyub
authors.identifier: http://orcid.org/0000-0003-2784-3772
authors.initials: J
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Soo Wan
authors.identifier: http://orcid.org/0000-0002-3540-9004
authors.initials: SW
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Inje University, Pusan Paik Hospital, Busan, Korea.
authors.forename: Tae Hee
authors.identifier: http://orcid.org/0000-0002-3588-0146
authors.initials: TH
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Eulji Medical Center, Eulji University, Seoul, Korea.
authors.forename: Suah
authors.identifier: http://orcid.org/0000-0001-8434-9944
authors.initials: S
authors.lastname: Sung
authors.affiliation: Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. hansh@yuhs.ac.
authors.forename: Seung Hyeok
authors.identifier: http://orcid.org/0000-0001-7923-5635
authors.initials: SH
authors.lastname: Han
mesh_terms: D000328:Adult; D000368:Aged; D055109:Ankle Brachial Index; D044466:Asian People; D002097:C-Reactive Protein / Q000032:analysis; D002118:Calcium / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000209:etiology / Q000473:pathology*; D015331:Cohort Studies; D003928:Diabetic Nephropathies / Q000150:complications; D005260:Female; D005919:Glomerular Filtration Rate; D005921:Glomerulonephritis / Q000150:complications; D006352:Heart Ventricles / Q000503:physiopathology; D006801:Humans; D006977:Hypertension, Renal / Q000150:complications; D008297:Male; D008875:Middle Aged; D009393:Nephritis / Q000150:complications; D007690:Polycystic Kidney Diseases / Q000150:complications; D051436:Renal Insufficiency, Chronic / Q000209:etiology / Q000473:pathology*; D056910:Republic of Korea; D012307:Risk Factors; D012720:Severity of Illness Index; D020107:Troponin T / Q000032:analysis
chemical_list: D020107:Troponin T; D002097:C-Reactive Protein; D002118:Calcium
keywords: Cardiovascular Disease; Chronic Kidney Disease; Diabetes; Epidemiology; Glomerulonephritis; Hypertension; KNOW-CKD; Polycystic Kidney Disease