title: Abnormalities of regional brain function in Parkinson's disease: a meta-analysis of resting state functional magnetic resonance imaging studies.
abstract: There is convincing evidence that abnormalities of regional brain function exist in Parkinson's disease (PD). However, many resting-state functional magnetic resonance imaging (rs-fMRI) studies using amplitude of low-frequency fluctuations (ALFF) have reported inconsistent results about regional spontaneous neuronal activity in PD. Therefore, we conducted a comprehensive meta-analysis using the Seed-based d Mapping and several complementary analyses. We searched PubMed, Embase, and Web of Science databases for eligible whole-brain rs-fMRI studies that measured ALFF differences between patients with PD and healthy controls published from January 1st, 2000 until June 24, 2016. Eleven studies reporting 14 comparisons, comparing 421 patients and 381 healthy controls, were included. The most consistent and replicable findings in patients with PD compared with healthy controls were identified, including the decreased ALFFs in the bilateral supplementary motor areas, left putamen, left premotor cortex, and left inferior parietal gyrus, and increased ALFFs in the right inferior parietal gyrus. The altered ALFFs in these brain regions are related to motor deficits and compensation in PD, which contribute to understanding its neurobiological underpinnings and could serve as specific regions of interest for further studies.
authors.affiliation: Department of Neurology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, PR China.|Department of Neurology, The Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng, PR China.
authors.forename: PingLei
authors.initials: P
authors.lastname: Pan
authors.affiliation: Department of Neurology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, PR China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, PR China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Neurology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, PR China.
authors.forename: He
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, PR China.
authors.forename: DeNing
authors.initials: D
authors.lastname: Guan
authors.affiliation: Department of Neurology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, PR China.|The State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, Jiangsu, PR China.|Jiangsu Key Laboratory for Molecular Medicine, Nanjing University Medical School, Nanjing, Jiangsu, PR China.|Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, PR China.|Nanjing Neuropsychiatry Clinic Medical Center, Nanjing, PR China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Xu
mesh_terms: D000368:Aged; D001921:Brain / Q000002:abnormalities* / Q000503:physiopathology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000000981:diagnostic imaging*; D012044:Regression Analysis; D012146:Rest