title: Deflazacort: therapeutic index, relative potency and equivalent doses versus other corticosteroids.
abstract: Deflazacort is a synthetic corticosteroid characterized by a favourable pharmacokinetic profile, peculiar pharmacodynamic properties and a good safety profile. However, to the best of our knowledge, no dose-conversion table based on direct comparison of relative potencies between deflazacort and other main corticosteroids is currently available in scientific literature.
  
  
  
  This paper, while reporting a brief review of deflazacort pharmacological properties, its efficacy and tolerability in different clinical areas, has been designed with the specific aim of providing a new dose-conversion table of corticosteroids, including for the first time also deflazacort.
  
  
  
  We suggest that this new conversion table could be a useful tool for physicians who need to select the appropriate dose of deflazacort in their clinical practice.
authors.affiliation: Department of Pharmacy, University of Salerno, Fisciano, Salerno, Italy. lparente@unisa.it.
authors.forename: Luca
authors.initials: L
authors.lastname: Parente
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D011282:Pregnenediones / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology; D013810:Therapeutic Equivalency; D000076162:Therapeutic Index
chemical_list: D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents; D011282:Pregnenediones; C021988:deflazacort
keywords: Corticosteroids; Deflazacort; Equipotency ratio; Relative potencies; Therapeutic efficacy; Tolerability