title: Angiotropic syringomatous carcinoma.
abstract: Syringomatous carcinoma (SC) is a slow-growing malignant skin tumor that usually affects the face or scalp. An 83-year-old female developed SC on the sole, a rare location. Histopathologically, numerous ducts with few keratinizing cysts were seen in the upper dermis, and cords, strands and nests with sclerotic stroma were seen in the deep dermis and subcutis. In addition to the perineural and intraneural invasion of the tumor, the tumor cells had also invaded the vessel walls. There was no intravasation of tumor cells or interruption of the endothelium. Because melanoma with vascular wall invasion without intravasation of melanoma cells or interruption of the endothelium has been called angiotropic melanoma, we termed the present tumor angiotropic SC. Tumor cells showed wide local invasion.
authors.affiliation: Department of Dermatology, Kurume University School of Medicine, Kurume, Japan.
authors.forename: Eri
authors.initials: E
authors.lastname: Katayama
authors.affiliation: Department of Dermatology, Kurume University School of Medicine, Kurume, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Saruta
authors.affiliation: Department of Dermatology, Kurume University School of Medicine, Kurume, Japan.
authors.forename: Aya
authors.initials: A
authors.lastname: Nanri
authors.affiliation: Department of Dermatology, Kurume University School of Medicine, Kurume, Japan.
authors.forename: Takekuni
authors.initials: T
authors.lastname: Nakama
authors.affiliation: Department of Dermatology, Kurume University School of Medicine, Kurume, Japan.
authors.forename: Chika
authors.identifier: http://orcid.org/0000-0001-8341-7300
authors.initials: C
authors.lastname: Ohata
mesh_terms: D000369:Aged, 80 and over; D003560:Cysts / Q000378:metabolism / Q000473:pathology; D020405:Dermis / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D008545:Melanoma / Q000378:metabolism / Q000473:pathology; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology; D018252:Syringoma / Q000378:metabolism / Q000473:pathology
keywords: angiotropic syringomatous carcinoma; intraneural invasion; microcystic adnexal carcinoma; sole; vascular wall invasion