title: Mechanism of Hepatocyte Apoptosis.
abstract: Hepatocyte apoptosis plays important roles in both the removal of external microorganisms and the occurrence and development of liver diseases. Different conditions, such as virus infection, fatty liver disease, hepatic ischemia reperfusion, and drug-induced liver injury, are accompanied by hepatocyte apoptosis. This review summarizes recent research on the mechanism of hepatocyte apoptosis involving the classical extrinsic and intrinsic apoptotic pathways, endoplasmic reticulum stress, and oxidative stress-induced apoptosis. We emphasized the major causes of apoptosis according to the characteristics of different liver diseases. Several concerns regarding future research and clinical application are also raised.
authors.affiliation: Research Center on Aging and Medicine, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Cao
authors.affiliation: Research Center on Aging and Medicine, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
authors.forename: Xi-Bing
authors.initials: XB
authors.lastname: Quan
authors.affiliation: Department of Pathology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
authors.forename: Wen-Jiao
authors.initials: WJ
authors.lastname: Zeng
authors.affiliation: Department of Gastroenterology, Peking Union Medical College Hospital, Beijing, China.
authors.forename: Xiao-Ou
authors.initials: XO
authors.lastname: Yang
authors.affiliation: Research Center on Aging and Medicine, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
authors.forename: Ming-Jie
authors.initials: MJ
authors.lastname: Wang
keywords: drug-induced liver injury; fatty liver disease; hepatic ischemia reperfusion injury; hepatocyte apoptosis; signaling pathways; viral hepatitis