title: Knockdown of FOXR2 suppresses the tumorigenesis, growth and metastasis of prostate cancer.
abstract: Fork-head box R2 (FOXR2), a member of FOX protein family, was reported to play important roles in the development and progression of cancers. However, the expression and function of FOXR2 in prostate cancer remain unclear. In this study, we investigated the role of FOXR2 in prostate cancer and cancer progression including the molecular mechanism that drives FOXR2-mediated oncogenesis. Our results showed that FOXR2 was overexpressed in prostate cancer cell lines. The in vitro experiments demonstrated that knockdown of FOXR2 significantly repressed the proliferation, migration and invasiveness of prostate cancer cells. Furthermore, the in vivo experiments indicated that knockdown of FOXR2 significantly attenuated prostate cancer growth. Finally, knockdown of FOXR2 significantly down-regulated the protein expression levels of β-catenin, cyclinD1 and c-Myc in DU-145 cells. Taken together, our results demonstrated for the first time that FOXR2 plays a critical role in cell proliferation and invasion, at least in part, through inhibiting the Wnt/β-catenin signaling pathway during prostate cancer progression. Thus, FOXR2 may be an attractive therapeutic target for the treatment of prostate cancer.
authors.affiliation: Department of Urology, Huaihe Hospital of Henan University, Kaifeng 475000, Henan Province, China.
authors.forename: Weibo
authors.initials: W
authors.lastname: Xu
authors.affiliation: Department of Urology, Huaihe Hospital of Henan University, Kaifeng 475000, Henan Province, China.
authors.forename: Junkai
authors.initials: J
authors.lastname: Chang
authors.affiliation: Antibody Drug Engineering Laboratory of Henan Province, Kaifeng 475000, Henan Province, China.
authors.forename: Guangchao
authors.initials: G
authors.lastname: Liu
authors.affiliation: Department of Urology, Huaihe Hospital of Henan University, Kaifeng 475000, Henan Province, China.
authors.forename: Xinyi
authors.initials: X
authors.lastname: Du
authors.affiliation: Department of Urology, Huaihe Hospital of Henan University, Kaifeng 475000, Henan Province, China. Electronic address: xiaodongurol@126.com.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Li
mesh_terms: D063646:Carcinogenesis / Q000235:genetics*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000235:genetics*; D018450:Disease Progression; D015536:Down-Regulation / Q000235:genetics; D051858:Forkhead Transcription Factors / Q000235:genetics*; D055785:Gene Knockdown Techniques / Q000379:methods; D006801:Humans; D008297:Male; D009361:Neoplasm Invasiveness / Q000235:genetics* / Q000473:pathology; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology*; D060449:Wnt Signaling Pathway / Q000235:genetics; D051176:beta Catenin / Q000235:genetics
chemical_list: C499816:FOXR2 protein, human; D051858:Forkhead Transcription Factors; D051176:beta Catenin
keywords: Fork-head box R2 (FOXR2); Invasion; Proliferation; Prostate cancer