title: The regulator of calcineurin 1 (RCAN1) inhibits nuclear factor kappaB signaling pathway and suppresses human malignant glioma cells growth.
abstract: Nuclear factor-kappaB (NF-κB) has a vital role in cell survival and inhibition of NF-κB had proven to be an efficient therapeutic pathway for various cancers though little is known about the underlying mechanism. Previously we identified regulator of calcineurin 1 (RCAN1) as an endogenous inhibitor of NF-κB signaling pathway in lymphoma. In the present study, we have solid data to show that RCAN1 can inhibit the nuclear translocation of NF-κB protein then affect the activity of NF-κB signaling pathway in glioma cells. Overexpression of RCAN1 markedly reduced glioma cells viability. We further found that the suppressing glioma cell growth was closely related to the pro-apoptosis effect, not by inhibiting proliferation by the arrest of cell cycle. Our study implicated a novel therapeutic approach for glioma by RCAN1 through inhibition of NF-κB signaling.
authors.affiliation: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, P. R. China.|China National Clinical Research Center for Neurological Diseases, Beijing, P. R. China.|Center of Stroke, Beijing Institute for Brain Disorders, Beijing, P. R. China.|Beijing Key Laboratory of Translational Medicine for Cerebrovascular Diseases, Beijing, P. R. China.
authors.forename: Xin
authors.initials: X
authors.lastname: Chen
authors.affiliation: Brain Research Institute, Qilu Hospital of Shandong University, Jinan, Shandong Province, China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, P. R. China.|China National Clinical Research Center for Neurological Diseases, Beijing, P. R. China.|Center of Stroke, Beijing Institute for Brain Disorders, Beijing, P. R. China.|Beijing Key Laboratory of Translational Medicine for Cerebrovascular Diseases, Beijing, P. R. China.
authors.forename: Shuo
authors.initials: S
authors.lastname: Wang
authors.affiliation: Brain Research Institute, Qilu Hospital of Shandong University, Jinan, Shandong Province, China.
authors.forename: Xiulian
authors.initials: X
authors.lastname: Sun
mesh_terms: D017209:Apoptosis; D001932:Brain Neoplasms / Q000378:metabolism* / Q000473:pathology; D019703:Calcineurin / Q000378:metabolism*; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D004268:DNA-Binding Proteins; D005910:Glioma / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000096:biosynthesis / Q000378:metabolism*; D009124:Muscle Proteins / Q000096:biosynthesis / Q000378:metabolism*; D016328:NF-kappa B / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D004268:DNA-Binding Proteins; D047908:Intracellular Signaling Peptides and Proteins; D009124:Muscle Proteins; D016328:NF-kappa B; C108612:RCAN1 protein, human; D019703:Calcineurin
keywords: NF-κB signaling; RCAN1; apoptosis; glioma; suppress