title: [Analysis of the association of interleukin 4 and interleukin 10 gene variants with basic personality traits].
abstract: There is growing evidence that serum levels of various inflammation markers are associated with personality traits. However, only few studies investigated the link between genetic variants of cytokine encoding genes and psychological characteristics. In this study, we examined genotypes in 297 individuals to assess the association between common variants of interleukin 4 (IL-4) and interleukin 10 (IL-10) genes and basic personality traits of extraversion and neuroticism, measured using the Eysenck Personality Questionnaire (EPQ). We found that, in homozygous female carriers of high expression alleles Т (IL-4 C-589T) and G (IL-10 G-1082A), neuroticism scores were higher (p = 0.045 and p = 0.08, respectively). In turn, extraversion scores were significantly higher in both male and female carriers of heterozygous variants CT and GA (p = 0.01). Our results are in accordance with the behavioral immune system hypothesis, and the general paradigm on the role of personality traits in health and longevity.
authors.affiliation: Mental Health Research Center, Moscow, 117152 Russia.|golimbet@mail.ru.
authors.forename: V E
authors.initials: VE
authors.lastname: Golimbet
authors.affiliation: Mental Health Research Center, Moscow, 117152 Russia.
authors.forename: M V
authors.initials: MV
authors.lastname: Alfimova
authors.affiliation: Mental Health Research Center, Moscow, 117152 Russia.
authors.forename: G I
authors.initials: GI
authors.lastname: Korovaitseva
authors.affiliation: Mental Health Research Center, Moscow, 117152 Russia.
authors.forename: T V
authors.initials: TV
authors.lastname: Lezheiko
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D015847:Interleukin-4 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010551:Personality / Q000235:genetics*; D011110:Polymorphism, Genetic; D019655:Quantitative Trait, Heritable; D011795:Surveys and Questionnaires
chemical_list: C508609:IL10 protein, human; C508598:IL4 protein, human; D016753:Interleukin-10; D015847:Interleukin-4
keywords: cytokines; gene polymorphism; health; inflammation; personality; temperament