title: Effects of Aqueous Extracts ofCynanchum wilfordiiin Rat Models for Postmenopausal Hot Flush.
abstract: Menopausal hot flushes (HFs), which manifest as a transient increase in skin temperature, occur most frequently in postmenopausal women, and sometimes negatively influence daily life. We investigated the effect of an aqueous extract ofCynanchum wilfordii(CWW) in a rat model of menopausal HFs, where tail skin temperature (TST) is increased after the rapid estrogen decline induced by ovariectomy. Ten-week-old female rats were ovariectomized and treated with CWW for 1 week. We measured TST and rectal temperatures (RT) and investigated serum estradiol. The TST in ovariectomized (OVX) rats was significantly elevated after ovariectomy compared with control rats, whereas the RT in OVX rats was not elevated. Administration of CWW (200 mg/kg/d for 7 days, p.o.) significantly improved the skin temperature increase in OVX rats. The lower level of serum estradiol in OVX rats was significantly increased by supplying E2, but it was not affected by CWW. The present study indicates a need for future research involving treatment with high concentrations ofC. wilfordiiand measurement over 24 h.
authors.affiliation: Division of Food and Nutrition, Chonnam National University, Gwangju 61186, Korea; Jeollanamdo Institute of Natural Resources Research, Jeonnam 59338, Korea.
authors.forename: Gyuok
authors.initials: G
authors.lastname: Lee
authors.affiliation: Jeollanamdo Institute of Natural Resources Research, Jeonnam 59338, Korea.
authors.forename: Chul-Yung
authors.initials: CY
authors.lastname: Choi
authors.affiliation: Division of Food and Nutrition, Chonnam National University, Gwangju 61186, Korea.
authors.forename: Woojin
authors.initials: W
authors.lastname: Jun
keywords: Cynanchum wilfordii; anti-hot flush; ovariectomy; tail skin temperature