title: Predictive factors of long-term colorectal cancer survival after ultrasound-controlled ablation of hepatic metastases.
abstract: OBJECTIVE
  The risk factors associated to long-term survival were assessed in patients with liver metastases of colorectal carcinoma undergoing ablative therapies.
  
  
  METHODS
  Single-centre cohort study, retrospectively analysed and prospectively collected consecutive patients with unresectable metastatic liver disease of colorectal carcinoma treated with ablative therapies between 1996 and 2013. Factors associated with survival time were identified using Cox's proportional hazard model with time-dependent covariates. A forward variable selection based on Akaike information criterion was performed. Relative risk and 95% confidence intervals for each factor were calculated. Statistical significance was set as P<.05.
  
  
  RESULTS
  Seventy-five patients with liver metastases of colorectal cancer, with a mean age of 65.6 (10.3) underwent 106 treatments. Variables selected were good quality of life (RR 0.308, 95% CI 0.150-0.632) and tumour extension (RR 3.070, 95% CI 1.776-5.308). The median overall survival was 18.5 months (95% CI 17.4-24.4). The survival prognosis in median was 13.5 vs. 23.4 months for patients with and without tumour extension, and 23.0 vs. 12.8 months for patients with good and fair or poor quality of life, respectively.
  
  
  CONCLUSIONS
  Good quality of life and tumour extension were the only statistically significant predictors of long-term survival in patients of colorectal carcinoma with liver metastatic disease undergoing ablative treatment with ultrasound.
authors.affiliation: Unidad de Ecografía Intervencionista, Servicio de Radiología, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Las Palmas, España. Electronic address: chersoc@gobiernodecanarias.org.
authors.forename: Carmen Rosa
authors.initials: CR
authors.lastname: Hernández-Socorro
authors.affiliation: Departamento de Matemáticas, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Las Palmas, España.
authors.forename: Pedro
authors.initials: P
authors.lastname: Saavedra
authors.affiliation: Servicio de Cirugía General, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Las Palmas, España.
authors.forename: José
authors.initials: J
authors.lastname: Ramírez Felipe
authors.affiliation: Servicio de Oncología, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Las Palmas, España.
authors.forename: Uriel
authors.initials: U
authors.lastname: Bohn Sarmiento
authors.affiliation: Servicio de Medicina Intensiva, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Las Palmas, España.
authors.forename: Sergio
authors.initials: S
authors.lastname: Ruiz-Santana
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000401:mortality / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006498:Hepatectomy / Q000379:methods*; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis; D016896:Treatment Outcome; D018084:Ultrasonography, Interventional
keywords: Ablation techniques; Calidad de vida; Colorectal neoplasms; Ecografía intervencionista; Interventional ultrasound; Liver neoplasms; Neoplasias colorrectales; Neoplasias del hígado; Quality of life; Técnicas de ablación