title: Solid-state NMR at natural isotopic abundance for the determination of conformational polymorphism - the case of designed β-turn peptides containing di-prolines.
abstract: The proton double quantum-carbon single quantum correlation experiment has been applied to designed peptides in the solid state in natural isotopic abundance. Analogous to nOe studies in solution, through-space double-quantum connectivities have been exploited to obtain the cis-trans conformational polymorphism of diproline residues occurring at β-turns in the peptides.
authors.affiliation: Department of Physics, Indian Institute of Science, Bangalore-560012, India and NMR Research Center, Indian Institute of Science, Bangalore-560012, India. sr@nrc.iisc.ernet.in kvr.nmr@gmail.com and Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fedérale de Lausanne, Switzerland.
authors.forename: Jayasubba Reddy
authors.initials: JR
authors.lastname: Yarava
authors.affiliation: NMR Research Center, Indian Institute of Science, Bangalore-560012, India. sr@nrc.iisc.ernet.in kvr.nmr@gmail.com and Molecular Biophysics Unit, Indian Institute of Science, Bangalore-560012, India and Biozentrum, Structural Biology, Universität Basel, Basel, Switzerland.
authors.forename: Rajesh
authors.initials: R
authors.lastname: Sonti
authors.affiliation: Molecular Biophysics Unit, Indian Institute of Science, Bangalore-560012, India and Department of Chemistry, Rani Channamma University, Belgavi, India.
authors.forename: K
authors.initials: K
authors.lastname: Kantharaju
authors.affiliation: NMR Research Center, Indian Institute of Science, Bangalore-560012, India. sr@nrc.iisc.ernet.in kvr.nmr@gmail.com.
authors.forename: S
authors.initials: S
authors.lastname: Raghothama
authors.affiliation: NMR Research Center, Indian Institute of Science, Bangalore-560012, India. sr@nrc.iisc.ernet.in kvr.nmr@gmail.com.
authors.forename: K V
authors.identifier: http://orcid.org/0000-0002-3949-0575
authors.initials: KV
authors.lastname: Ramanathan
mesh_terms: D019906:Nuclear Magnetic Resonance, Biomolecular; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry*; D011392:Proline / Q000737:chemistry*; D011487:Protein Conformation; D011522:Protons; D011789:Quantum Theory
chemical_list: D010455:Peptides; D011522:Protons; D011392:Proline