title: Use of intracranial pressure monitoring in bacterial meningitis: a 10-year follow up on outcome and intracranial pressure versus head CT scans.
abstract: BACKGROUND
  The aim of this study was to evaluate the clinical outcome of patients with severe bacterial meningitis where intracranial pressure (ICP) monitoring has been performed.
  
  
  METHODS
  A retrospective observational study including patients admitted 1st.January 2005 to 31st.December 2014. Thirty nine patients age 18-89 years were included. All the patients received intensive care with mechanical ventilation, ICP monitoring, sedation, antibiotics and corticosteroids according to current guidelines. Clinical outcome was defined as death during hospitalization or survival at hospital discharge.
  
  
  RESULTS
  The most common pathogen was Streptococcus pneumoniae (26; 67%). Thirteen patients died (33%) and neurologic impairment was noted in twenty two (84.6%) surviving patients. In S. pneumoniae cases patients with adverse outcome were significantly older (p = 0.0024) and immunosuppressed (p = 0.034). Lower mean-cerebral perfusion pressure (CPP) was found to correlate with adverse outcome (p = 0.005). Cerebrospinal fluid (CSF) was drained in fourteen patients. Increased ICP (>20 mmHg) was observed in twenty four patients. No significant correlation was found between measured ICP and head CT scans with signs of elevated ICP.
  
  
  CONCLUSIONS
  Patients with severe meningitis should be admitted to intensive care units and evaluated for ICP monitoring regardless of head CT findings.
authors.affiliation: a Department of Infectious Diseases, Odense University Hospital, Odense, Denmark.
authors.forename: Lykke
authors.initials: L
authors.lastname: Larsen
authors.affiliation: b Department of Neurosurgery , Odense University Hospital , Odense , Denmark.|c Clinical Institute , University of Southern Denmark , Copenhagen , Denmark.
authors.forename: Frantz R
authors.initials: FR
authors.lastname: Poulsen
authors.affiliation: b Department of Neurosurgery , Odense University Hospital , Odense , Denmark.|c Clinical Institute , University of Southern Denmark , Copenhagen , Denmark.
authors.forename: Troels H
authors.initials: TH
authors.lastname: Nielsen
authors.affiliation: b Department of Neurosurgery , Odense University Hospital , Odense , Denmark.|c Clinical Institute , University of Southern Denmark , Copenhagen , Denmark.
authors.forename: Carl-Henrik
authors.initials: CH
authors.lastname: Nordström
authors.affiliation: b Department of Neurosurgery , Odense University Hospital , Odense , Denmark.|c Clinical Institute , University of Southern Denmark , Copenhagen , Denmark.
authors.forename: Mette K
authors.initials: MK
authors.lastname: Schulz
authors.affiliation: a Department of Infectious Diseases, Odense University Hospital, Odense, Denmark.|d Department of Infectious Diseases , Copenhagen University Hospital Rigshospitalet , Copenhagen , Denmark.
authors.forename: Åse B
authors.initials: ÅB
authors.lastname: Andersen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016903:Drug Monitoring / Q000379:methods*; D005260:Female; D006257:Head / Q000000981:diagnostic imaging*; D006801:Humans; D007427:Intracranial Pressure; D008297:Male; D016920:Meningitis, Bacterial / Q000188:drug therapy* / Q000473:pathology*; D008875:Middle Aged; D012189:Retrospective Studies; D016019:Survival Analysis; D014057:Tomography, X-Ray Computed / Q000379:methods*; D016896:Treatment Outcome; D055815:Young Adult
keywords: Bacterial meningitis; head CT scan; intracranial pressure monitoring