title: Association analysis of ANK3 variants with bipolar disorder in the Korean population.
abstract: BACKGROUND
  Bipolar disorder (BD) is a major psychiatric disorder characterized by alternating mood episodes, including major depressive, hypomanic, and manic episodes. Previous genetic studies of BD have reported several genes as potentially associated with BD. The ANK3 gene has been identified as a possible BD susceptibility gene in genome-wide association analyses.
  
  
  OBJECTIVE
  The goal of the present study was to evaluate the association of ANK3 variants with BD in the Korean population.
  
  
  METHODS
  Based on previous results, two single nucleotide polymorphisms (SNPs), rs1938526 and rs10994336, were selected in the ANK3 gene. The study included 287 BD patients and 340 healthy controls. Case-control association and case-control haplotype analyses of the two ANK3 variants were performed.
  
  
  RESULTS
  No significant association was found of either single SNP with BD by case-control association analysis. However, rs1938526 and rs10994336 showed a significant association (overall p = 3.6 × 10-11; permutation p = 0) in a case-control haplotype analysis.
  
  
  CONCLUSIONS
  The haplotype analysis results suggest that ANK3 variants rs1938526 and rs10994336 may confer susceptibility for BD in the Korean population. Association analysis revealed a probable genetic difference between Korean and Caucasian populations in the degree of ANK3 involvement in BD pathogenesis.
authors.affiliation: a Department of Psychiatry , Korea University College of Medicine , Seoul , South Korea.
authors.forename: Chul-Hyun
authors.initials: CH
authors.lastname: Cho
authors.affiliation: b Department of Biomedical Sciences , Korea University College of Medicine , Seoul , South Korea.
authors.forename: Soojin
authors.initials: S
authors.lastname: Kim
authors.affiliation: b Department of Biomedical Sciences , Korea University College of Medicine , Seoul , South Korea.
authors.forename: Dongho
authors.initials: D
authors.lastname: Geum
authors.affiliation: a Department of Psychiatry , Korea University College of Medicine , Seoul , South Korea.|b Department of Biomedical Sciences , Korea University College of Medicine , Seoul , South Korea.
authors.forename: Heon-Jeong
authors.initials: HJ
authors.lastname: Lee
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics*; D001714:Bipolar Disorder / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics*; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D008875:Middle Aged; D056910:Republic of Korea
keywords: ANK3; Bipolar disorder; haplotype analysis; polymorphism