title: No Association between Radiation Dose from Pediatric CT Scans and Risk of Subsequent Hodgkin Lymphoma.
abstract: Background:We examined the relationship between estimated radiation dose from CT scans and subsequent Hodgkin lymphoma in the UK pediatric CT scans cohort.Methods:A retrospective, record linkage cohort included patients ages 0 to 21 years who underwent CT scans between 1980 and 2002 and were followed up for cancer or death until 2008. Poisson regression analysis was used to evaluate the relationship between estimated radiation dose (lagged by 2 years) and incident Hodgkin lymphoma diagnosed at least 2 years after the first CT scan.Results:There were 65 incident cases of Hodgkin lymphoma in the cohort of 178,601 patients. Neither estimated red bone marrow dose nor mean lymphocyte dose from CT scans was clearly associated with an increased risk of Hodgkin lymphoma (RR for 20+ mGy vs. <5 mGy = 0.92 (0.38-2.22)Ptrend> 0.5 and 1.44 (0.60-3.48)Ptrend> 0.5), respectively.Conclusions:Radiation exposure from pediatric CT scans 2 or more years before diagnosis was not associated with Hodgkin lymphoma in this large UK cohort.Impact:These findings are consistent with the majority of previous studies, which do not support a link between ionizing radiation and Hodgkin lymphoma. The results contrast our previous positive findings in this cohort for brain tumors and leukemia, both of which are known to be strongly linked to radiation exposure during childhood.Cancer Epidemiol Biomarkers Prev; 26(5); 804-6. ©2017 AACR.
authors.affiliation: Division of Cancer Epidemiology & Genetics, NCI, Bethesda, Maryland. berringtona@mail.nih.gov.
authors.forename: Amy
authors.initials: A
authors.lastname: Berrington de Gonzalez
authors.affiliation: Division of Cancer Epidemiology & Genetics, NCI, Bethesda, Maryland.
authors.forename: Neige
authors.initials: N
authors.lastname: Journy
authors.affiliation: Division of Cancer Epidemiology & Genetics, NCI, Bethesda, Maryland.
authors.forename: Choonsik
authors.initials: C
authors.lastname: Lee
authors.affiliation: Division of Cancer Epidemiology & Genetics, NCI, Bethesda, Maryland.
authors.forename: Lindsay M
authors.initials: LM
authors.lastname: Morton
authors.affiliation: Institute of Health & Society, Newcastle University, Newcastle, United Kingdom.|Health Protection Research Unit, Newcastle University, Newcastle, United Kingdom.
authors.forename: Richard W
authors.initials: RW
authors.lastname: Harbron
authors.affiliation: Division of Cancer Epidemiology & Genetics, NCI, Bethesda, Maryland.
authors.forename: Douglas R
authors.initials: DR
authors.lastname: Stewart
authors.affiliation: Department of Medicine, Dalhousie University, Halifax, Canada.
authors.forename: Louise
authors.initials: L
authors.lastname: Parker
authors.affiliation: Institute of Health & Society, Newcastle University, Newcastle, United Kingdom.
authors.forename: Alan W
authors.initials: AW
authors.lastname: Craft
authors.affiliation: Radiology Department, Great Ormond Street Hospital, London, United Kingdom.
authors.forename: Kieran
authors.initials: K
authors.lastname: McHugh
authors.affiliation: Division of Cancer Epidemiology & Genetics, NCI, Bethesda, Maryland.
authors.forename: Mark P
authors.initials: MP
authors.lastname: Little
authors.affiliation: Institute of Health & Society, Newcastle University, Newcastle, United Kingdom.|Health Protection Research Unit, Newcastle University, Newcastle, United Kingdom.
authors.forename: Mark S
authors.initials: MS
authors.lastname: Pearce
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006689:Hodgkin Disease / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology*; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed / Q000009:adverse effects*; D006113:United Kingdom / Q000453:epidemiology; D055815:Young Adult