title: Clinical outcomes of AML patients treated with Azacitidine in Portugal: A retrospective multicenter study.
abstract: Retrospective data was collected from 77 elderly acute myeloid leukemia (AML) patients treated with Azacitidine (AZA) and 50 elderly AML patients treated with intensive chemotherapy (IC) from 4 Portuguese Hospitals. Median OS was 10.6 months in those receiving AZA as 1st line. Response (overall response rate 44%) had a significant impact on overall survival (p=<0.0001). Median OS of the comparator IC cohort was significantly inferior to that observed in the cohort treated with AZA in first line (p=0.0104). These results support the efficacy of AZA in AML in the elderly in any line of treatment.
authors.affiliation: Serviço de Hematologia, Instituto Português de Oncologia de Lisboa, Francisco Gentil, Lisbon, Portugal.
authors.forename: António
authors.initials: A
authors.lastname: Almeida
authors.affiliation: Serviço de Hematologia, Centro Hospitalar Lisboa Norte, Hospital Santa Maria, Lisboa, Portugal.
authors.forename: Ana Rita
authors.initials: AR
authors.lastname: Ferreira
authors.affiliation: Serviço de Hematologia, Centro Hospitalar Lisboa Norte, Hospital Santa Maria, Lisboa, Portugal.
authors.forename: Maria João
authors.initials: MJ
authors.lastname: Costa
authors.affiliation: Serviço de Hematologia, Centro Hospitalar Lisboa Norte, Hospital Santa Maria, Lisboa, Portugal.
authors.forename: Sofia
authors.initials: S
authors.lastname: Silva
authors.affiliation: Serviço de Hematologia, Instituto Português de Oncologia de Lisboa, Francisco Gentil, Lisbon, Portugal.
authors.forename: Khalil
authors.initials: K
authors.lastname: Alnajjar
authors.affiliation: Serviço de Hematologia, Instituto Português de Oncologia de Lisboa, Francisco Gentil, Lisbon, Portugal.
authors.forename: Isabel
authors.initials: I
authors.lastname: Bogalho
authors.affiliation: Serviço de Hematologia, Instituto Português de Oncologia de Lisboa, Francisco Gentil, Lisbon, Portugal.
authors.forename: Francesca
authors.initials: F
authors.lastname: Pierdomenico
authors.affiliation: Serviço de Hematologia, Instituto Português de Oncologia de Lisboa, Francisco Gentil, Lisbon, Portugal.
authors.forename: Susana
authors.initials: S
authors.lastname: Esteves
authors.affiliation: Serviço de Hematologia, Hospital São João, Porto, Portugal.
authors.forename: Mafalda
authors.initials: M
authors.lastname: Alpoim
authors.affiliation: Serviço de Hematologia, Hospital São João, Porto, Portugal.
authors.forename: Gil
authors.initials: G
authors.lastname: Braz
authors.affiliation: Serviço de Hematologia, Centro Hospitalar Universitário de Coimbra, Coimbra, Portugal.
authors.forename: Emilia
authors.initials: E
authors.lastname: Cortesão
authors.affiliation: Serviço de Hematologia, Hospital São João, Porto, Portugal.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Pinto
keywords: Acute myeloid leukemia; Azacitidine; Elderly; Hypomethylating agents