title: Synthesis of 1-Difluoroalkylated Isoquinolines via Palladium-Catalyzed Radical Cascade Difluoroalkylation-Cyclization of Vinyl Isocyanides with Bromodifluoroacetic Derivatives.
abstract: A general method was developed for the synthesis of 1-difluoroalkyl isoquinolines via the palladium-catalyzed radical cascade difluoroalkylation-cyclization of vinyl isocyanides with bromodifluoroacetic derivatives. The difluoroalkylated cyclization products were readily converted to various other valuable gem-difluoro-containing compounds.
authors.affiliation: School of Chemistry and Environmental Engineering, Sichuan University of Science & Engineering, 180 Xueyuan Street, Huixing Lu, Zigong, Sichuan, 643000, China.
authors.forename: Yingle
authors.initials: Y
authors.lastname: Liu
authors.affiliation: College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 2999 North Renmin Road, Shanghai, 201620, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Zhang
authors.affiliation: School of Chemistry and Environmental Engineering, Sichuan University of Science & Engineering, 180 Xueyuan Street, Huixing Lu, Zigong, Sichuan, 643000, China.
authors.forename: Weidong
authors.initials: W
authors.lastname: Jiang
authors.affiliation: School of Chemistry and Environmental Engineering, Sichuan University of Science & Engineering, 180 Xueyuan Street, Huixing Lu, Zigong, Sichuan, 643000, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Yang
authors.affiliation: School of Chemistry and Environmental Engineering, Sichuan University of Science & Engineering, 180 Xueyuan Street, Huixing Lu, Zigong, Sichuan, 643000, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: School of Chemistry and Environmental Engineering, Sichuan University of Science & Engineering, 180 Xueyuan Street, Huixing Lu, Zigong, Sichuan, 643000, China.
authors.forename: Xiaoqiang
authors.initials: X
authors.lastname: Liu
authors.affiliation: School of Chemistry and Environmental Engineering, Sichuan University of Science & Engineering, 180 Xueyuan Street, Huixing Lu, Zigong, Sichuan, 643000, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Xie
authors.affiliation: School of Chemistry and Environmental Engineering, Sichuan University of Science & Engineering, 180 Xueyuan Street, Huixing Lu, Zigong, Sichuan, 643000, China.
authors.forename: Jincai
authors.initials: J
authors.lastname: Wu
authors.affiliation: School of Chemistry and Environmental Engineering, Sichuan University of Science & Engineering, 180 Xueyuan Street, Huixing Lu, Zigong, Sichuan, 643000, China.
authors.forename: Junjie
authors.initials: J
authors.lastname: Cai
authors.affiliation: Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, 345 Lingling Road, Shanghai, 200032, China.
authors.forename: Xiu-Hua
authors.initials: XH
authors.lastname: Xu
keywords: difluoroalkylation; gem-difluoromethylene; isoquinolines; palladium; radical reactions