title: Bio-orthogonal "click-and-release" donation of caged carbonyl sulfide (COS) and hydrogen sulfide (H2S).
abstract: Hydrogen sulfide (H2S) is an important biomolecule with high therapeutic potential. Here we leverage the inverse-electron demand Diels-Alder (IEDDA) click reaction between a thiocarbamate-functionalized trans-cyclooctene and a tetrazine to deliver carbonyl sulfide (COS), which is quickly converted to H2S by the uniquitous enzyme carbonic anhydrase (CA), thus providing a new strategy for bio-orthogonal COS/H2S donation.
authors.affiliation: Materials Science Institute, Institute of Molecular Biology, Department of Chemistry and Biochemistry, University of Oregon, Eugene, OR 97403, USA. pluth@uoregon.edu.
authors.forename: Andrea K
authors.identifier: http://orcid.org/0000-0003-1655-7973
authors.initials: AK
authors.lastname: Steiger
authors.affiliation: Department of Chemistry, University at Albany, SUNY, 1400 Washington Avenue, Albany, NY 12222, USA. mroyzen@albany.edu.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Chemistry, University at Albany, SUNY, 1400 Washington Avenue, Albany, NY 12222, USA. mroyzen@albany.edu.
authors.forename: Maksim
authors.initials: M
authors.lastname: Royzen
authors.affiliation: Materials Science Institute, Institute of Molecular Biology, Department of Chemistry and Biochemistry, University of Oregon, Eugene, OR 97403, USA. pluth@uoregon.edu.
authors.forename: Michael D
authors.identifier: http://orcid.org/0000-0003-3604-653X
authors.initials: MD
authors.lastname: Pluth