title: Reversible Vesicle-to-Disk Transitions of Liposomes Induced by the Self-Assembly of Water-Soluble Porphyrins.
abstract: Structural control of lipid membranes is important for mechanisms underlying biological functions and for creating high-functionality soft materials. We demonstrate the reversible control of vesicle structures (liposomes) using supramolecular assemblies. Specifically, water-soluble anionic porphyrin molecules interact with positively charged lipid membrane surfaces to form one-dimensional self-assembled structures (J-aggregates) under acidic conditions. Cryogenic transmission electron microscopy revealed that porphyrin J-aggregates on the membrane surface induced an extensive structural change from vesicles to layered disks. Neutralization of the solution deformed the porphyrin J-aggregates, thereby reforming nanosized liposomes from the layered disks.
authors.affiliation: Department of Applied Chemistry, Graduate School of Engineering, Hiroshima University , Higashi-Hiroshima 739-8527, Japan.
authors.forename: Kouta
authors.identifier: 0000-0001-6634-6782
authors.initials: K
authors.lastname: Sugikawa
authors.affiliation: Department of Applied Chemistry, Graduate School of Engineering, Hiroshima University , Higashi-Hiroshima 739-8527, Japan.
authors.forename: Yutaro
authors.initials: Y
authors.lastname: Takamatsu
authors.affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology , Nara 630-0192, Japan.
authors.forename: Kazuma
authors.initials: K
authors.lastname: Yasuhara
authors.affiliation: Department of Applied Chemistry, Graduate School of Engineering, Hiroshima University , Higashi-Hiroshima 739-8527, Japan.
authors.forename: Masafumi
authors.initials: M
authors.lastname: Ueda
authors.affiliation: Department of Applied Chemistry, Graduate School of Engineering, Hiroshima University , Higashi-Hiroshima 739-8527, Japan.
authors.forename: Atsushi
authors.identifier: 0000-0003-3492-3455
authors.initials: A
authors.lastname: Ikeda
mesh_terms: D008081:Liposomes / Q000737:chemistry*; D008968:Molecular Conformation; D011166:Porphyrins / Q000737:chemistry*; D012995:Solubility; D014867:Water / Q000737:chemistry*
chemical_list: D008081:Liposomes; D011166:Porphyrins; D014867:Water