title: Antisynthetase syndrome: Analysis of 11 cases.
abstract: BACKGROUND
  Antisynthetase syndrome (ASS) is characterised by a series of clinical manifestations such as myositis, fever, mechanic's hands and diffuse interstitial lung disease (ILD), all associated with positivity to antisynthetase antibodies. The presence of ILD will be that, to a great extent it will mark the response to treatment and prognosis.
  
  
  METHODS
  Eleven cases of patients with ASS and pulmonary involvement in monitoring at a Pulmonary monographic consult in a third level hospital consult are described.
  
  
  RESULTS
  Nine patients presented positivity to anti-Jo antibody and 2 to anti-PL12. Four patients' HRCT pattern showed NSIP, four UIP, one COP and 2 ground-glass opacity. A percentage of 73 were accompanied by bronchiectasis and bronchiolectasis and 27% honeycombing. Functional exploration was mainly affected by DLCO with up to 45% of the positive walking test. Corticodependence is highlighted, often requiring immunosuppressive treatment both chronically and in exacerbations. All patients maintain good prognosis so far.
  
  
  CONCLUSIONS
  Patients with interstitial lung disease should have at least a determination of antisynthetase antibodies in order to identify this disease, better prognosis than other interstitial diseases such as idiopathic pulmonary fibrosis.
authors.affiliation: Servicio de Neumología, Hospital Universitario La Paz, Instituto de Investigación Hospital Universitario La Paz (IdiPAZ), Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Universidad Autónoma de Madrid, Madrid, España. Electronic address: ester.zamarron@gmail.com.
authors.forename: Ester
authors.initials: E
authors.lastname: Zamarrón-de Lucas
authors.affiliation: Servicio de Neumología, Hospital Universitario La Paz, Instituto de Investigación Hospital Universitario La Paz (IdiPAZ), Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Universidad Autónoma de Madrid, Madrid, España.
authors.forename: Luis
authors.initials: L
authors.lastname: Gómez Carrera
authors.affiliation: Servicio de Reumatología, Hospital Universitario La Paz, Instituto de Investigación Hospital Universitario La Paz (IdiPAZ), Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Universidad Autónoma de Madrid, Madrid, España.
authors.forename: Gema
authors.initials: G
authors.lastname: Bonilla
authors.affiliation: Servicio de Neumología, Hospital Universitario La Paz, Instituto de Investigación Hospital Universitario La Paz (IdiPAZ), Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Universidad Autónoma de Madrid, Madrid, España.
authors.forename: Dessiree
authors.initials: D
authors.lastname: Petit
authors.affiliation: Servicio de Neumología, Hospital Universitario La Paz, Instituto de Investigación Hospital Universitario La Paz (IdiPAZ), Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Universidad Autónoma de Madrid, Madrid, España.
authors.forename: Alberto
authors.initials: A
authors.lastname: Mangas
authors.affiliation: Servicio de Neumología, Hospital Universitario La Paz, Instituto de Investigación Hospital Universitario La Paz (IdiPAZ), Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Universidad Autónoma de Madrid, Madrid, España.
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Álvarez-Sala
mesh_terms: D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D017563:Lung Diseases, Interstitial / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009220:Myositis / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D011379:Prognosis; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents
keywords: Anticuerpos antisintetasa; Antisynthetase antibodies; Enfermedad pulmonar intersticial; Lung interstitial disease; Miositis; Myositis