title: From Slow to Fast: Hypogravity-Induced Remodeling of Muscle Fiber Myosin Phenotype.
abstract: Skeletal muscle consists of different fiber types arranged in a mosaic pattern. These fiber types are characterized by specific functional properties. Slow-type fibers demonstrate a high level of fatigue resistance and prolonged contraction duration, but decreased maximum contraction force and velocity. Fast-type fibers demonstrate high contraction force and velocity, but profound fatigability. During the last decades, it has been discovered that all these properties are determined by the predominance of slow or fast myosin-heavy-chain (MyHC) isoforms. It was observed that gravitational unloading during space missions and simulated microgravity in ground-based experiments leads to the transformation of some slow-twitch muscle fibers into fast-twitch ones due to changes in the patterns of MyHC gene expression in the posturalsoleus muscle. The present review covers the facts and mechanistic speculations regarding myosin phenotype remodeling under conditions of gravitational unloading. The review considers the neuronal mechanisms of muscle fiber control and molecular mechanisms of regulation of myosin gene expression, such as inhibition of the calcineurin/NFATc1 signaling pathway, epigenomic changes, and the behavior of specific microRNAs. In the final portion of the review, we discuss the adaptive role of myosin phenotype transformations.
authors.affiliation: State Scientific Center of the Russian Federation - Institute of Biomedical Problems, Russian Academy of Sciences, Khoroshevskoe shosse, 76A, Moscow, 123007, Russia.
authors.forename: B S
authors.initials: BS
authors.lastname: Shenkman
keywords: gravitational unloading; muscle fiber type; myosin gene expression; myosin heavy chain isoform; myosin phenotype; skeletal muscle