title: LPS infusion suppresses serum FGF21 levels in healthy adult volunteers.
abstract: BACKGROUND
  During the inflammatory acute phase response, plasma glucose and serum triglycerides are increased in humans. Fibroblast growth factor (FGF) 21 has plasma glucose and lipid-reducing actions, but its role in the acute inflammatory response in human is unknown.
  
  
  OBJECTIVE
  To investigate circulating levels of FGF21 after lipopolysaccharide (LPS) infusion.
  
  
  METHODS
  Two randomized, single-blinded, placebo-controlled crossover trials were used.
  
  
  METHODS
  The studies were performed at a university hospital clinical research center.
  
  
  METHODS
  Study 1 (LPS bolus): Eight young, healthy, lean males were investigated two times: (1) after isotonic saline injection and (2) after LPS injection (bolus of 1 ng/kg). Each study day lasted 4 h. Study 2 (continuous LPS infusion): Eight, healthy males were investigated two times: (1) during continuously isotonic saline infusion and (2) during continuous LPS infusion (0.06 ng/kg/h). Each study day lasted 4 h. Circulating FGF21 levels were quantified every second hour by an immunoassay.
  
  
  RESULTS
  A LPS bolus resulted in a late suppression (t = 240 min) of serum FGF21 (P = 0.035). Continuous LPS infusion revealed no significant effects on FGF21 levels (P = 0.82).
  
  
  CONCLUSIONS
  Our studies show that a bolus of LPS results in decreased FGF21 levels 4 h from exposure.
authors.affiliation: The Medical Research LaboratoriesInstitute of Clinical Research, Aarhus University, Aarhus C, Denmark esben.lauritzen@clin.au.dk.|Department of Endocrinology and Internal MedicineAarhus University Hospital, Aarhus C, Denmark.
authors.forename: Esben S
authors.initials: ES
authors.lastname: Lauritzen
authors.affiliation: The Medical Research LaboratoriesInstitute of Clinical Research, Aarhus University, Aarhus C, Denmark.|Department of Endocrinology and Internal MedicineAarhus University Hospital, Aarhus C, Denmark.
authors.forename: Nikolaj
authors.initials: N
authors.lastname: Rittig
authors.affiliation: The Medical Research LaboratoriesInstitute of Clinical Research, Aarhus University, Aarhus C, Denmark.|Department of Endocrinology and Internal MedicineAarhus University Hospital, Aarhus C, Denmark.
authors.forename: Ermina
authors.initials: E
authors.lastname: Bach
authors.affiliation: The Medical Research LaboratoriesInstitute of Clinical Research, Aarhus University, Aarhus C, Denmark.|Department of Endocrinology and Internal MedicineAarhus University Hospital, Aarhus C, Denmark.
authors.forename: Niels
authors.initials: N
authors.lastname: Møller
authors.affiliation: The Medical Research LaboratoriesInstitute of Clinical Research, Aarhus University, Aarhus C, Denmark.
authors.forename: Mette
authors.initials: M
authors.lastname: Bjerre
keywords: FGF21; LPS; inflammation