title: Microcirculatory Assessment of Arterial Below-Knee Stumps: Near-Infrared Spectroscopy Versus Transcutaneous Oxygen Tension-A Preliminary Study in Prosthesis Users.
abstract: To examine metrologic properties of near-infrared spectroscopy (NIRS) versus transcutaneous oxygen tension (TcPO2) for microcirculatory assessment of vascular transtibial stumps at the stabilized period of prosthesis fitting, as a preliminary step before exploring its ability to predict stump healing, considering the previously identified limits of TcPO2(borderline area between 15 and 35mmHg).
  
  
  
  Prospective single-center observational study.
  
  
  
  University-based rehabilitation center.
  
  
  
  Individuals with unilateral transtibial amputation for peripheral artery disease, at the definitive stage of prosthesis fitting, able to perform a 2-minute walk test (N=30).
  
  
  
  Not applicable.
  
  
  
  Test-retest, with the stump being evaluated in supine and inclined positions, first by NIRS (tissue saturation index [TSI], oxyhemoglobin, deoxyhemoglobin, and total hemoglobin) and second by TcPO2. Subjects carried out a 2-minute walk test and visual analog scales (wound healing and pain).
  
  
  
  Feasibility and tolerance of NIRS were satisfactory. The reliability of NIRS and TcPO2values was good (intraclass correlation coefficient >0.7; P<.05). No significant relation was found between NIRS and TcPO2. No responsiveness (inclined vs supine) was reported (P>.05). A significant relation between TSI and the 2-minute walk test (r>.49, P<.05) was found.
  
  
  
  NIRS is painless, complication-free, and feasible, with good reliability. NIRS evaluates others domain than TcPO2that are more linked to metabolic adaptation. Its capacity to predict stump healing and tolerance to early prosthesis fitting is therefore interesting to estimate in future studies.
authors.affiliation: Centre d'Investigation Clinique INSERM 1432, Plateforme d'Investigation Technologique, Centre Hospitalier Universitaire de Dijon, Dijon, France; CAPS UMR 1093, INSERM, Université de Bourgogne Franche-Comté, F21000 Dijon, France.
authors.forename: Davy
authors.initials: D
authors.lastname: Laroche
authors.affiliation: Pôle Rééducation-Réadaptation, Centre Hospitalier Universitaire de Dijon, Dijon, France.
authors.forename: José-Luis
authors.initials: JL
authors.lastname: Barnay
authors.affiliation: Pôle Rééducation-Réadaptation, Centre Hospitalier Universitaire de Dijon, Dijon, France.
authors.forename: Bastien
authors.initials: B
authors.lastname: Tourlonias
authors.affiliation: Pôle Rééducation-Réadaptation, Centre Hospitalier Universitaire de Dijon, Dijon, France.
authors.forename: Cyril
authors.initials: C
authors.lastname: Orta
authors.affiliation: Pôle Rééducation-Réadaptation, Centre Hospitalier Universitaire de Dijon, Dijon, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Obert
authors.affiliation: Centre d'Investigation Clinique INSERM 1432, Plateforme d'Investigation Technologique, Centre Hospitalier Universitaire de Dijon, Dijon, France; CAPS UMR 1093, INSERM, Université de Bourgogne Franche-Comté, F21000 Dijon, France; Pôle Rééducation-Réadaptation, Centre Hospitalier Universitaire de Dijon, Dijon, France. Electronic address: jean-marie.casillas@chu-dijon.fr.
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Casillas
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000671:Amputation, Surgical / Q000534:rehabilitation*; D000672:Amputation Stumps / Q000098:blood supply*; D001186:Artificial Limbs; D005260:Female; D006801:Humans; D008297:Male; D008833:Microcirculation / Q000502:physiology*; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D058729:Peripheral Arterial Disease / Q000601:surgery; D026741:Physical Therapy Modalities; D011446:Prospective Studies; D015203:Reproducibility of Results; D019265:Spectroscopy, Near-Infrared / Q000379:methods*
chemical_list: D010100:Oxygen
keywords: Amputation stumps; Blood gas monitoring, transcutaneous; Rehabilitation; Spectroscopy, near-infrared