title: Network-Based Approach to Identify Potential Targets and Drugs that Promote Neuroprotection and Neurorepair in Acute Ischemic Stroke.
abstract: Acute ischemic stroke (AIS) accounts for more than 80% of the approximately 610,000 new stroke cases worldwide every year. Both ischemia and reperfusion can cause death, damage, and functional changes of affected nerve cells, and these alterations can result in high rates of disability and mortality. Therefore, therapies aimed at increasing neuroprotection and neurorepair would make significant contributions to AIS management. However, with regard to AIS therapies, there is currently a large gap between experimental achievements and practical clinical solutions (EC-GAP-AIS). Here, by integrating curated disease-gene associations and interactome network known to be related to AIS, we investigated the molecular network mechanisms of multi-module structures underlying AIS, which might be relevant to the time frame subtypes of AIS. In addition, the EC-GAP-AIS phenomenon was confirmed and elucidated by the shortest path lengths and the inconsistencies in the molecular functionalities and overlapping pathways between AIS-related genes and drug targets. Furthermore, we identified 23 potential targets (e.g. ADORA3, which is involved in the regulation of cellular reprogramming and the extracellular matrix) and 46 candidate drugs (e.g. felbamate, methylphenobarbital and memantine) that may have value for the treatment of AIS.
authors.affiliation: Department of Biomedical Engineering, Faculty of Electronic Information and Electrical Engineering, Dalian University of Technology, Dalian 116024, China.|Liaoning Provincial Key Laboratory of Cerebral Diseases, Institute for Brain Disorders, Dalian Medical University, Dalian 116044, China.
authors.forename: Yiwei
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Biomedical Engineering, Faculty of Electronic Information and Electrical Engineering, Dalian University of Technology, Dalian 116024, China.
authors.forename: Hailong
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Neurology, the Second Affiliated Hospital of Dalian Medical University, Dalian 116027, China.
authors.forename: Yongzhong
authors.initials: Y
authors.lastname: Lin
authors.affiliation: School of Computer and Information Technology and Beijing Key Lab of Traffic Data Analysis and Mining, Beijing Jiaotong University, Beijing 100044, China.
authors.forename: Guangming
authors.initials: G
authors.lastname: Liu
authors.affiliation: Liaoning Provincial Key Laboratory of Cerebral Diseases, Institute for Brain Disorders, Dalian Medical University, Dalian 116044, China.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Chu
authors.affiliation: School of Computer and Information Technology and Beijing Key Lab of Traffic Data Analysis and Mining, Beijing Jiaotong University, Beijing 100044, China.
authors.forename: Pengyao
authors.initials: P
authors.lastname: Zhao
authors.affiliation: Liaoning Provincial Key Laboratory of Cerebral Diseases, Institute for Brain Disorders, Dalian Medical University, Dalian 116044, China.
authors.forename: Xiaohan
authors.initials: X
authors.lastname: Yang
authors.affiliation: Liaoning Provincial Key Laboratory of Cerebral Diseases, Institute for Brain Disorders, Dalian Medical University, Dalian 116044, China.
authors.forename: Tiezheng
authors.initials: T
authors.lastname: Zheng
authors.affiliation: Institute of Basic Medical Sciences, Academy of Military Medical Sciences, Beijing 100850, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Fan
authors.affiliation: School of Computer and Information Technology and Beijing Key Lab of Traffic Data Analysis and Mining, Beijing Jiaotong University, Beijing 100044, China.
authors.forename: Xuezhong
authors.initials: X
authors.lastname: Zhou
authors.affiliation: College of Electrical Engineering, Zhejiang University, Hangzhou 310027, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Meng
authors.affiliation: Department of Biomedical Engineering, Faculty of Electronic Information and Electrical Engineering, Dalian University of Technology, Dalian 116024, China.|Liaoning Provincial Key Laboratory of Cerebral Diseases, Institute for Brain Disorders, Dalian Medical University, Dalian 116044, China.|Research Center for the Control Engineering of Translational Precision Medicine, Dalian University of Technology, Dalian 116024, China.|State Key Laboratory of Fine Chemicals, Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian 116024, China.
authors.forename: Changkai
authors.initials: C
authors.lastname: Sun
mesh_terms: D004194:Disease / Q000235:genetics*; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D053263:Gene Regulatory Networks; D056726:Genetic Association Studies; D006801:Humans; D008490:Medical Informatics / Q000379:methods*; D018696:Neuroprotective Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D020521:Stroke / Q000188:drug therapy*
chemical_list: D018696:Neuroprotective Agents