title: Management and counseling of the male with advanced paternal age.
abstract: Increasing percentages of children are being born to older fathers. This has resulted in concerns about the potential adverse effects of advanced paternal age. To help clinicians counsel couples, a systemic review was performed to attempt to address questions that these couples may ask: Should routine sperm testing be performed in older males? Should preimplantation genetic diagnosis (PGD) be performed? How do providers counsel patients about risk? Should young males freeze sperm if they plan to delay paternity? Using the terms "advanced paternal age", "semen testing", "preimplantation genetic diagnosis/screening", and "cryopreservation", a comprehensive search was performed in PubMed and the Cochrane Library, and numerous international societal guidelines were reviewed. In total, 42 articles or guidelines were reviewed. There were no limits placed on the timing of the articles. Thirty articles were found to be relevant and beneficial to answering the above questions. Each question was answered separately by the supporting literature. While primary research exists to support the role of semen testing, PGD/preimplantation genetic screening, and sperm banking in males who may be affected by advancing age, comprehensive studies on the possible clinical benefit of these interventions have yet to be performed. As a result, societal guidelines have yet to incorporate distinct best-practice guidelines on advanced paternal age.
authors.affiliation: Division of Urology, Department of Surgery, Graduate School of Medicine, University of Tennessee, Knoxville, Tennessee. Electronic address: mjennings@utmck.edu.
authors.forename: Michael O
authors.initials: MO
authors.lastname: Jennings
authors.affiliation: Division of Urology, Department of Surgery, Graduate School of Medicine, University of Tennessee, Knoxville, Tennessee.
authors.forename: Ryan C
authors.initials: RC
authors.lastname: Owen
authors.affiliation: Department of Obstetrics and Gynecology, New York University Langone Medical Center, New York, New York.
authors.forename: David
authors.initials: D
authors.lastname: Keefe
authors.affiliation: Division of Urology, Department of Surgery, Graduate School of Medicine, University of Tennessee, Knoxville, Tennessee.
authors.forename: Edward D
authors.initials: ED
authors.lastname: Kim
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D003376:Counseling; D015925:Cryopreservation; D005260:Female; D005298:Fertility; D005820:Genetic Testing; D006304:Health Status; D006801:Humans; D007248:Infertility, Male / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010331:Paternal Age; D011247:Pregnancy; D019836:Preimplantation Diagnosis; D027724:Reproductive Techniques, Assisted / Q000009:adverse effects; D018570:Risk Assessment; D012307:Risk Factors; D055101:Semen Analysis; D012662:Semen Preservation; D013094:Spermatozoa / Q000473:pathology
keywords: Advanced; age; fertility; paternal; semen