title: Age and sex influence on bone and blood lead concentrations in a cohort of the general population living in Toronto.
abstract: To study the age and sex influence on bone and blood lead concentrations in a cohort of the general population living in Toronto.
  
  
  
  A109Cd K x-ray fluorescence (KXRF) measurement system was used from 2009 to 2011 in a study that measured the bone lead (Pb) concentration of 263 environmentally exposed individuals residing in Toronto, Ontario, Canada. Tibia (cortical bone) and calcaneus (trabecular bone) lead contents were measured in 134 males and 129 females between 1 and 82 years of age. Whole blood Pb concentration was measured by TIMS (thermal ionization mass spectrometer). Tibia (Ti) and calcaneus (Cal) Pb were examined versus the age of participants, taking into account uncertainties in bone Pb measurement values.
  
  
  
  No significant sex differences were observed in any of the age categories. Participants older than 50 years of age demonstrated the highest concentrations of Pb in their blood, tibia, and calcaneus bones.
  
  
  
  In most of the previous publications, uncertainty was not considered in the regression model of bone Pb and age. However, in this paper, we adjusted the bone Pb values for the uncertainty level. This had a significant influence in regression models of bone Pb and thus we recommend that uncertainty be considered in future studies.
authors.affiliation: McMaster University, Hamilton, ON, Canada.
authors.forename: S
authors.initials: S
authors.lastname: Behinaein
authors.forename: D R
authors.initials: DR
authors.lastname: Chettle
authors.forename: M
authors.initials: M
authors.lastname: Fisher
authors.forename: W I
authors.initials: WI
authors.lastname: Manton
authors.forename: L
authors.initials: L
authors.lastname: Marro
authors.forename: D E B
authors.initials: DE
authors.lastname: Fleming
authors.forename: N
authors.initials: N
authors.lastname: Healey
authors.forename: M
authors.initials: M
authors.lastname: Inskip
authors.forename: T E
authors.initials: TE
authors.lastname: Arbuckle
authors.forename: F E
authors.initials: FE
authors.lastname: McNeill
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000097:blood* / Q000378:metabolism* / Q000502:physiology; D002111:Calcaneus / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007223:Infant; D007854:Lead / Q000097:blood* / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009864:Ontario; D012727:Sex Characteristics; D013977:Tibia / Q000378:metabolism*; D055815:Young Adult
chemical_list: D007854:Lead