title: Conservative Treatment of Large Aplasia Cutis Congenita of the Scalp With Bone Defect With Basic Fibroblast Growth Factor Application.
abstract: The object of this report is to share our experience of conservative management of giant aplasia cutis congenita (ACC) of the scalp with the topical application of basic fibroblast growth factor (bFGF). Complete epithelialization of the 9 × 8 cm sized defect was achieved in 33 weeks. Careful conservative management could eliminate the requirement of surgery for giant ACC defects of the scalp with bone defects and should be tried if surgery is thought to be risky or has consecutive morbidity. Topical bFGF application seems to accelerate healing, also providing a better epithelium for later reconstructive treatments and its usage could be standardized in the future.
authors.affiliation: *Department of Plastic and Reconstructive Surgery, Juntendo University School of Medicine †Department of Neurosurgery, Juntendo University School of Medicine, Tokyo, Japan.
authors.forename: Doruk
authors.initials: D
authors.lastname: Orgun
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Horiguchi
authors.forename: Ayato
authors.initials: A
authors.lastname: Hayashi
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Shimoji
authors.forename: Hajime
authors.initials: H
authors.lastname: Arai
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mizuno
mesh_terms: D000287:Administration, Topical; D000072700:Conservative Treatment; D004476:Ectodermal Dysplasia / Q000188:drug therapy*; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D014945:Wound Healing / Q000187:drug effects
chemical_list: D016222:Fibroblast Growth Factor 2