title: SUMOylation in Neurological Diseases.
abstract: Since the discovery of SUMOs (small ubiquitin-like modifiers) over 20 years ago, sumoylation has recently emerged as an important posttranslational modification involved in almost all aspects of cellular physiology. In neurons, sumoylation dynamically modulates protein function and consequently plays an important role in neuronal maturation, synapse formation and plasticity. Thus, the dysfunction of sumoylation pathway is associated with many different neurological disorders. Hundreds of different proteins implicated in the pathogenesis of neurological disorders are SUMO-modified, indicating the importance of sumoylation involved in the neurological diseases. In this review, we summarize the growing findings on protein sumoylation in neuronal function and dysfunction. It is essential to have a thorough understanding on the mechanism how sumoylation contributes to neurological diseases in developing efficient therapy for these diseases.
authors.forename: F-Y
authors.initials: FY
authors.lastname: Liu
authors.forename: Y-F
authors.initials: YF
authors.lastname: Liu
authors.forename: Y
authors.initials: Y
authors.lastname: Yang
authors.forename: Z-W
authors.initials: ZW
authors.lastname: Luo
authors.forename: J-W
authors.initials: JW
authors.lastname: Xiang
authors.forename: Z-G
authors.initials: ZG
authors.lastname: Chen
authors.forename: R-L
authors.initials: RL
authors.lastname: Qi
authors.forename: T-H
authors.initials: TH
authors.lastname: Yang
authors.forename: Y
authors.initials: Y
authors.lastname: Xiao
authors.forename: W-J
authors.initials: WJ
authors.lastname: Qing
authors.affiliation: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, #54 Xianlie South Road, Guangzhou, Guangdong 510060,. China.
authors.forename: D W-C
authors.initials: DW
authors.lastname: Li
mesh_terms: D006801:Humans; D009422:Nervous System Diseases / Q000235:genetics* / Q000503:physiopathology; D055495:Neurogenesis / Q000235:genetics*; D009474:Neurons / Q000378:metabolism / Q000473:pathology; D011499:Protein Processing, Post-Translational / Q000235:genetics*; D058207:Sumoylation / Q000235:genetics*; D025801:Ubiquitin / Q000235:genetics
chemical_list: D025801:Ubiquitin
keywords: Sumoylation; neurological diseases; neuronal function; synapse formation