title: Carboxymethylcellulose/ZnCdS fluorescent quantum dot nanoconjugates for cancer cell bioimaging.
abstract: In this study, it is reported the use of sodium carboxymethyl cellulose (CMCel) as a multifunctional biocompatible polysaccharide for the direct synthesis of fluorescent alloyed-ZnCdS quantum dot (QD) nanoconjugates via aqueous "green" process at room temperature. The nanoconjugates were extensively characterized by spectroscopical (NMR, FTIR, UV-vis, PL) and morphological techniques (DLS, TEM) for accessing their structural and physicochemical properties associated with X-ray photoelectron spectroscopy (XPS) for surface and interface analysis. The results proved the hypothesis of formation of core-shell nanostructures composed by the semiconductor ZnCdS QD core and the organic biocompatible ligand CMCel shell. Moreover, CMCel chemical functional groups played a pivotal role for controlling the size of water-soluble colloidal nanocrystals (2r=4-5nm) and hydrodynamic diameters (<15nm) evidenced by metal complexation and interactions at the nanointerfaces. Additionally, these nanoconjugates were cytocompatible and luminescent for bioimaging human osteosarcoma cancer cells. Thus, these novel polysaccharide-based fluorescent bioconjugates offer promising perspectives as nanoplatforms for cancer cell bioimaging and diagnosis purposes.
authors.affiliation: Center of Nanoscience, Nanotechnology and Innovation - CeNano(2)I, Department of Metallurgical and Materials Engineering, Federal University of Minas Gerais, Brazil.
authors.forename: Alexandra A P
authors.initials: AAP
authors.lastname: Mansur
authors.affiliation: Center of Nanoscience, Nanotechnology and Innovation - CeNano(2)I, Department of Metallurgical and Materials Engineering, Federal University of Minas Gerais, Brazil.
authors.forename: Fernanda G
authors.initials: FG
authors.lastname: de Carvalho
authors.affiliation: Center of Nanoscience, Nanotechnology and Innovation - CeNano(2)I, Department of Metallurgical and Materials Engineering, Federal University of Minas Gerais, Brazil.
authors.forename: Rafael L
authors.initials: RL
authors.lastname: Mansur
authors.affiliation: Center of Nanoscience, Nanotechnology and Innovation - CeNano(2)I, Department of Metallurgical and Materials Engineering, Federal University of Minas Gerais, Brazil.
authors.forename: Sandhra M
authors.initials: SM
authors.lastname: Carvalho
authors.affiliation: Department of Chemistry, Federal University of Minas Gerais, Brazil.
authors.forename: Luiz Carlos
authors.initials: LC
authors.lastname: de Oliveira
authors.affiliation: Center of Nanoscience, Nanotechnology and Innovation - CeNano(2)I, Department of Metallurgical and Materials Engineering, Federal University of Minas Gerais, Brazil. Electronic address: hmansur@demet.ufmg.br.
authors.forename: Herman S
authors.initials: HS
authors.lastname: Mansur
mesh_terms: D002104:Cadmium / Q000737:chemistry; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry*; D045744:Cell Line, Tumor; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D008958:Models, Molecular; D008968:Molecular Conformation; D057054:Molecular Imaging / Q000379:methods*; D058726:Nanoconjugates / Q000737:chemistry*; D045663:Quantum Dots / Q000737:chemistry*; D013440:Sulfides / Q000737:chemistry; D017967:Zinc Compounds / Q000737:chemistry*
chemical_list: D005456:Fluorescent Dyes; D058726:Nanoconjugates; D013440:Sulfides; D017967:Zinc Compounds; D002104:Cadmium; D002266:Carboxymethylcellulose Sodium
keywords: Biopolymer; Carboxymethyl cellulose; Polysaccharides