title: Honey and Wound Healing: An Update.
abstract: For centuries, honey has been utilized for wound healing purposes. In recent times, this specific topic has become a field of interest, possibly due to the advent of antibiotic resistance in microbial pathogens. With constant technological advancement, the information regarding honey's mechanisms of action on wound healing has accumulated at a rapid pace. Similarly, clinical studies comparing honey with traditional wound care therapies are steadily emerging. As a follow-up to a previous review published in the journal in 2011, the current review article outlines publications regarding honey and wound healing that have been published between June 2010 and August 2016. Here we describe the most recent evidence regarding multiple types of honey and their mechanisms of action as antimicrobial agents, immunologic modulators, and physiologic mediators. In addition, outcomes of clinical studies involving a multitude of cutaneous wounds are also examined.
authors.affiliation: University of Central Florida College of Medicine, 3300 Kings Road South, Saint Augustine, FL, 32086, USA.
authors.forename: Sami K
authors.initials: SK
authors.lastname: Saikaly
authors.affiliation: SUNY Downstate, 450 Clarkson Avenue, Brooklyn, NY, 11203, USA. amorkh@gmail.com.
authors.forename: Amor
authors.identifier: http://orcid.org/0000-0002-5409-3201
authors.initials: A
authors.lastname: Khachemoune
mesh_terms: D000287:Administration, Topical; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D001458:Bandages; D006722:Honey; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000890:Anti-Infective Agents; D007155:Immunologic Factors