title: Prevalence of Gastric Non-Helicobacter pylori-Helicobacters in Japanese Patients with Gastric Disease.
abstract: BACKGROUND
  Non-Helicobacter pylori-helicobacters (NHPH) compose a group of gram negative zoonotic bacteria that may induce in humans gastric diseases including gastritis, gastroduodenal ulcer and MALT lymphoma. Their prevalence in the general population has previously been reported to 0.1-6.2%, although such reports still remain less in number.
  
  
  OBJECTIVE
  This study aimed at estimating the prevalence of gastric NHPH in Japanese people, and further aimed at linking this to different gastric diseases and co-infection with H. pylori.
  
  
  METHODS
  Endoscopically obtained biopsy samples from 280 Japanese patients with various gastric diseases were collected. Samples were analyzed by immunohistochemistry and by species-specific PCR for detection of gastric helicobacters.
  
  
  RESULTS
  The total prevalence of gastric NHPH among 280 Japanese patients was 6.1%, and the prevalence of H. pylori was 65.7%. There was no significant difference in prevalence of either NHPH or H. pylori when infected with H. pylori or NHPH, respectively. NHPH infection was found to be the highest in patients with gastric MALT lymphoma and duodenal ulcer, the former being independent of co-infection with H. pylori and the latter being dependent.
  
  
  CONCLUSIONS
  This study reports a total prevalence of 6.1% of gastric NHPH in Japanese patients, and further highlights gastric MALT lymphoma and duodenal ulcer (when co-infected with H. pylori) as important related diseases.
authors.affiliation: Center for Clinical Pharmacy and Clinical Sciences, School of Pharmacy, Kitasato University, Tokyo, Japan.
authors.forename: Anders
authors.initials: A
authors.lastname: Øverby
authors.forename: Somay Y
authors.initials: SY
authors.lastname: Murayama
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Michimae
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Suzuki
authors.forename: Masayuki
authors.initials: M
authors.lastname: Suzuki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Serizawa
authors.forename: Ryo
authors.initials: R
authors.lastname: Tamura
authors.forename: Shinichi
authors.initials: S
authors.lastname: Nakamura
authors.forename: Shinichi
authors.initials: S
authors.lastname: Takahashi
authors.forename: Masahiko
authors.initials: M
authors.lastname: Nakamura
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004381:Duodenal Ulcer / Q000453:epidemiology / Q000382:microbiology; D005260:Female; D005753:Gastric Mucosa / Q000382:microbiology / Q000473:pathology; D016998:Helicobacter; D016481:Helicobacter Infections / Q000453:epidemiology* / Q000382:microbiology; D006801:Humans; D007150:Immunohistochemistry; D007564:Japan / Q000453:epidemiology; D018442:Lymphoma, B-Cell, Marginal Zone / Q000453:epidemiology / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D015995:Prevalence; D013272:Stomach Diseases / Q000453:epidemiology / Q000382:microbiology* / Q000473:pathology; D055815:Young Adult