title: Combined prednisolone and pirfenidone in bleomycin-induced lung disease.
abstract: Bleomycin is a cytostatic drug commonly employed in the treatment of Hodgkin's disease, seminomas, and choriocarcinoma. Bleomycin may induce a chronic pulmonary inflammation that may progress to fibrosis. So far, only corticosteroids have been used in the treatment of bleomycin-induced lung disease with variable results. Pirfenidone is an antifibrotic drug that has been approved for the treatment of idiopathic pulmonary fibrosis. We report two cases of bleomycin-induced lung disease treated successfully with pirfenidone and oral corticosteroids.
authors.affiliation: Institute of Pulmonology, Medical Research and Development; Lung Care and Sleep Center, Fortis Hospitals, Mumbai, Maharashtra, India.
authors.forename: Preyas J
authors.initials: PJ
authors.lastname: Vaidya
authors.affiliation: Institute of Pulmonology, Medical Research and Development, Mumbai, Maharashtra, India.
authors.forename: H S
authors.initials: HS
authors.lastname: Sandeepa
authors.affiliation: Department of Medical Oncology, Fortis Hospitals, Mumbai, Maharashtra, India.
authors.forename: Tejinder
authors.initials: T
authors.lastname: Singh
authors.affiliation: Department of Radiology, Dr. Balabhai Nanavati Hospital, Mumbai, Maharashtra, India.
authors.forename: S K
authors.initials: SK
authors.lastname: Susheel Kumar
authors.affiliation: Department of Radiology, Fortis Hospitals, Mumbai, Maharashtra, India.
authors.forename: Rajat
authors.initials: R
authors.lastname: Bhargava
authors.affiliation: Department of Medical Oncology, Dr. Balabhai Nanavati Hospital, Mumbai, Maharashtra, India.
authors.forename: Gopal
authors.initials: G
authors.lastname: Ramakrishnan
authors.affiliation: Institute of Pulmonology, Medical Research and Development; Lung Care and Sleep Center, Fortis Hospitals; Department of Respiratory Medicine, Dr. Balabhai Nanavati Hospital, Mumbai, Maharashtra, India.
authors.forename: Prashant N
authors.initials: PN
authors.lastname: Chhajed
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects*; D001761:Bleomycin / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D055370:Lung Injury / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use*; D011728:Pyridones / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D000903:Antibiotics, Antineoplastic; D011728:Pyridones; D001761:Bleomycin; D011239:Prednisolone; C093844:pirfenidone