title: Risk factors of progressive IgA nephropathy which progress to end stage renal disease within ten years: a case-control study.
abstract: There were few related studies aiming to severe IgA nephropathy (IgAN) which could progress rapidly to end stage renal disease (ESRD) within ten years. To find valuable clinical or pathological factors and promising precautions is essential.
  
  
  
  A single center case-control study was performed. Fifty ESRD patients with the primary cause of IgAN and a short renal survival time of less than ten years after diagnose were enrolled in the case group. One hundred IgAN patients with a renal survival time of more than ten years were enrolled in the control group. IgA Oxford classification scores, clinical data at baseline and during the follow-up were collected. Multivariate logistic regression was used to investigate factors associated with the development of ESRD.
  
  
  
  There were significant differences in baseline clinical data between these two groups, as well as the constituent ratio of Oxford MEST-score. Distinct differences were observed in time-average uric acid(TA-UA), time-average hemoglobin(TA-Hb), time-average albumin(TA-Alb), time-average total cholesterol(TA-TC) and time-average urinary protein(TA-P) during the follow-up. In multivariate logistic models, IgA Oxford score M1(OR = 5.10, P = 0.018) and eGFR(OR = 0.97, P = 0.039) at biopsy, TA-UA (OR = 2.06, P = 0.026) and TA-Hb (OR = 0.53, P = 0.022) during the follow-up were identified independent factors for developing ESRD.
  
  
  
  IgAN patients with pathological assessment of M1, low baseline eGFR, TA-Hb and high TA-UA were more likely to progress to ESRD, and should be paid more attention. Appropriate regulations of UA, Hb and urine protein after diagnose may be a promising treatment.
authors.affiliation: Department of Nephrology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
authors.forename: Danhua
authors.initials: D
authors.lastname: Shu
authors.affiliation: Department of Nephrology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
authors.forename: Feifei
authors.initials: F
authors.lastname: Xu
authors.affiliation: Department of Nephrology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. cnsuzhen@hotmail.com.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Su
authors.affiliation: Department of Nephrology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
authors.forename: Ji
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Nephrology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
authors.forename: Chaosheng
authors.initials: C
authors.lastname: Chen
authors.affiliation: Department of Nephrology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
authors.forename: Jianna
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Nephrology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
authors.forename: Xiaokai
authors.initials: X
authors.lastname: Ding
authors.affiliation: Department of Nephrology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
authors.forename: Yinqiu
authors.initials: Y
authors.lastname: Lv
authors.affiliation: Department of Nephrology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
authors.forename: Haixia
authors.initials: H
authors.lastname: Lin
authors.affiliation: Department of Nephrology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
authors.forename: Peipei
authors.initials: P
authors.lastname: Huang
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002784:Cholesterol / Q000378:metabolism; D018450:Disease Progression; D005260:Female; D005919:Glomerular Filtration Rate; D005922:Glomerulonephritis, IGA / Q000378:metabolism* / Q000473:pathology; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007668:Kidney / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000453:epidemiology / Q000378:metabolism* / Q000473:pathology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011507:Proteinuria / Q000453:epidemiology / Q000378:metabolism; D012709:Serum Albumin / Q000378:metabolism; D014527:Uric Acid / Q000378:metabolism
chemical_list: D006454:Hemoglobins; D012709:Serum Albumin; D014527:Uric Acid; D002784:Cholesterol
keywords: End stage renal disease; Follow-up clinical data; IgA nephropathy; Oxford classification