title: Deoxynivalenol (DON) Contamination of Feed and Grinding Fineness: Are There Interactive Implications on Stomach Integrity and Health of Piglets?
abstract: The common feed contaminant deoxynivalenol (DON) was reported to influence the morphology of thepars nonglandularis(PN) of porcine stomach. Moreover, finely ground feed is known to trigger the development of ulcers and other pathologies of PN while coarsely ground feed protects from such lesions. The interactions between grinding fineness and DON contamination of feed were not examined so far. Therefore, both finely and coarsely ground feeds were tested either in the absence or presence of a DON contaminated wheat on growth performance and health of rearing piglets, including stomach integrity. DON contamination significantly reduced feed intake and serum albumin concentration with this effect being more pronounced after feeding the coarsely ground feed. Albeit at a higher level, albumin concentration was also reduced after feeding the finely ground and uncontaminated feed. Finely ground and DON-contaminated feed caused a significantly more pronounced lymphoplasmacytic infiltration both of PN andpars glandularis, partly paralleled by lymph follicle formation and detritus filledfoveolaeand tubes suggesting a local immune response probably triggered by epithelial lesions. It is concluded that DON contamination of feed exacerbates the adverse effects of finely ground feed on stomach mucosal integrity.
authors.affiliation: Institute of Animal Nutrition, Friedrich-Loeffler-Institute (FLI), Federal Research Institute for Animal Health, Bundesallee 50, D-38116 Braunschweig, Germany. sven.daenicke@fli.de.
authors.forename: Sven
authors.initials: S
authors.lastname: Dänicke
authors.affiliation: Institute of Pathology, University of Veterinary Medicine Hannover, Foundation, Bünteweg 17, D30559 Hannover, Germany. andreas.beineke@tiho-hannover.de.
authors.forename: Andreas
authors.initials: A
authors.lastname: Beineke
authors.affiliation: Institute of Animal Nutrition, Friedrich-Loeffler-Institute (FLI), Federal Research Institute for Animal Health, Bundesallee 50, D-38116 Braunschweig, Germany. andreas.berk@fli.de.
authors.forename: Andreas
authors.initials: A
authors.lastname: Berk
authors.affiliation: Institute of Animal Nutrition, Friedrich-Loeffler-Institute (FLI), Federal Research Institute for Animal Health, Bundesallee 50, D-38116 Braunschweig, Germany. susanne.kersten@fli.de.
authors.forename: Susanne
authors.initials: S
authors.lastname: Kersten
mesh_terms: D000821:Animal Feed / Q000382:microbiology / Q000633:toxicity*; D000818:Animals; D000831:Animals, Newborn; D002478:Cells, Cultured; D004435:Eating; D005511:Food Handling / Q000379:methods*; D005516:Food Microbiology; D005753:Gastric Mucosa / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D018928:Immunity, Mucosal / Q000187:drug effects; D010316:Particle Size; D025341:Principal Component Analysis; D012709:Serum Albumin / Q000378:metabolism; D034421:Sus scrofa; D014255:Trichothecenes / Q000032:analysis / Q000633:toxicity*; D014908:Triticum / Q000382:microbiology / Q000633:toxicity*; D015430:Weight Gain
chemical_list: D012709:Serum Albumin; D014255:Trichothecenes; C007262:deoxynivalenol
keywords: deoxynivalenol; feed grinding fineness; pig; stomach pathology