title: Scale-up of nature's tissue weaving algorithms to engineer advanced functional materials.
abstract: We are literally the stuff from which our tissue fabrics and their fibers are woven and spun. The arrangement of collagen, elastin and other structural proteins in space and time embodies our tissues and organs with amazing resilience and multifunctional smart properties. For example, the periosteum, a soft tissue sleeve that envelops all nonarticular bony surfaces of the body, comprises an inherently "smart" material that gives hard bones added strength under high impact loads. Yet a paucity of scalable bottom-up approaches stymies the harnessing of smart tissues' biological, mechanical and organizational detail to create advanced functional materials. Here, a novel approach is established to scale up the multidimensional fiber patterns of natural soft tissue weaves for rapid prototyping of advanced functional materials. First second harmonic generation and two-photon excitation microscopy is used to map the microscopic three-dimensional (3D) alignment, composition and distribution of the collagen and elastin fibers of periosteum, the soft tissue sheath bounding all nonarticular bone surfaces in our bodies. Then, using engineering rendering software to scale up this natural tissue fabric, as well as multidimensional weaving algorithms, macroscopic tissue prototypes are created using a computer-controlled jacquard loom. The capacity to prototype scaled up architectures of natural fabrics provides a new avenue to create advanced functional materials.
authors.affiliation: Graduate School of Biomedical Engineering, University of New South Wales (UNSW) Australia, Sydney, Australia.
authors.forename: Joanna L
authors.initials: JL
authors.lastname: Ng
authors.affiliation: Graduate School of Biomedical Engineering, University of New South Wales (UNSW) Australia, Sydney, Australia.|School of Art &Design, University of New South Wales (UNSW) Australia, Sydney, Australia.
authors.forename: Lillian E
authors.initials: LE
authors.lastname: Knothe
authors.affiliation: Biomedical Imaging Facility, Mark Wainwright Analytical Centre, UNSW Australia, Sydney, Australia.
authors.forename: Renee M
authors.initials: RM
authors.lastname: Whan
authors.affiliation: Cleveland Clinic, Cleveland, USA.|TissuTex Pty Ltd, Wentworth Falls, Australia.
authors.forename: Ulf
authors.initials: U
authors.lastname: Knothe
authors.affiliation: Graduate School of Biomedical Engineering, University of New South Wales (UNSW) Australia, Sydney, Australia.
authors.forename: Melissa L Knothe
authors.initials: ML
authors.lastname: Tate
mesh_terms: D000465:Algorithms; D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology*; D001842:Bone and Bones / Q000033:anatomy & histology / Q000502:physiology; D003094:Collagen / Q000378:metabolism; D004549:Elastin / Q000378:metabolism; D005269:Femur / Q000502:physiology; D007091:Image Processing, Computer-Assisted; D009132:Muscles / Q000033:anatomy & histology / Q000502:physiology; D010521:Periosteum / Q000033:anatomy & histology / Q000502:physiology; D017785:Photons; D012756:Sheep; D023822:Tissue Engineering / Q000379:methods*
chemical_list: D001672:Biocompatible Materials; D003094:Collagen; D004549:Elastin