title: LATE-ONSET CHOROIDAL METASTASIS FROM BREAST CANCER.
abstract: OBJECTIVE
  Report occurrence of late-onset choroidal metastasis from breast cancer.
  
  
  METHODS
  Retrospective chart review.
  
  
  RESULTS
  The authors report 3 patients with choroidal metastasis from breast cancer that presented more than 20 years after diagnosis of the primary tumor. The choroidal metastases were the presenting feature of metastatic disease in all three patients, but after imaging, all patients had metastasis elsewhere as well. Two of the patients' tumors were known, ER+, and the hormone receptor status of the third patient was unknown. All three patients were treated with aromatase inhibitors with good response.
  
  
  CONCLUSIONS
  Late onset of metastatic disease, an excellent response to hormonal therapy, and a prolonged survival despite presence of systemic disease suggests a milder variant within the broad category of breast cancer patients with uveal metastases. Awareness of this entity can minimize the risk of misdiagnosis and avoid potentially toxic local therapy.
authors.affiliation: Department of Ophthalmic Oncology, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio.
authors.forename: Ashleigh L
authors.initials: AL
authors.lastname: Levison
authors.affiliation: Department of Ophthalmic Oncology, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio.
authors.forename: Feyza
authors.initials: F
authors.lastname: Erenler
authors.affiliation: Department of Ophthalmic Oncology, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio.
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Ophthalmic Oncology, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio.
authors.forename: Daniel F
authors.initials: DF
authors.lastname: Martin
authors.affiliation: Department of Ophthalmic Oncology, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio.
authors.forename: Careen
authors.initials: C
authors.lastname: Lowder
authors.affiliation: Taussig Cancer Center, Cleveland Clinic, Cleveland, Ohio.
authors.forename: G Thomas
authors.initials: GT
authors.lastname: Budd
authors.affiliation: Department of Ophthalmic Oncology, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio.
authors.forename: Arun D
authors.initials: AD
authors.lastname: Singh
mesh_terms: D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use; D047072:Aromatase Inhibitors / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000473:pathology*; D002830:Choroid Neoplasms / Q000473:pathology / Q000556:secondary*; D005260:Female; D006801:Humans; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D047072:Aromatase Inhibitors