title: Catalyst-free N-methylation of amines using CO2.
abstract: Recently, utilizing CO2as a methylation reagent to construct functional chemicals has attracted significant attention. However, the conversion of CO2is still a challenge due to its inherent inertness. In this study, we have developed a catalyst-free N-methylation of amines to prepare numerous methylamines using CO2as a methyl source. By utilizing 2 eq. PhSiH3as the reductant, amines could undergo N-methylation under 1 atm of CO2in DMF at 90 °C. Aliphatic and aromatic amines were compatible, generating the desired products in up to 95% yield.
authors.affiliation: College of Chemistry and Molecular Sciences, Institute for Advanced Studies (IAS), Wuhan University, Wuhan 430072, P. R. China. cwchiang@whu.edu.cn aiwenlei@whu.edu.cn.
authors.forename: Huiying
authors.initials: H
authors.lastname: Niu
authors.affiliation: College of Chemistry and Molecular Sciences, Institute for Advanced Studies (IAS), Wuhan University, Wuhan 430072, P. R. China. cwchiang@whu.edu.cn aiwenlei@whu.edu.cn.
authors.forename: Lijun
authors.initials: L
authors.lastname: Lu
authors.affiliation: College of Chemistry and Molecular Sciences, Institute for Advanced Studies (IAS), Wuhan University, Wuhan 430072, P. R. China. cwchiang@whu.edu.cn aiwenlei@whu.edu.cn.
authors.forename: Renyi
authors.initials: R
authors.lastname: Shi
authors.affiliation: College of Chemistry and Molecular Sciences, Institute for Advanced Studies (IAS), Wuhan University, Wuhan 430072, P. R. China. cwchiang@whu.edu.cn aiwenlei@whu.edu.cn.
authors.forename: Chien-Wei
authors.initials: CW
authors.lastname: Chiang
authors.affiliation: College of Chemistry and Molecular Sciences, Institute for Advanced Studies (IAS), Wuhan University, Wuhan 430072, P. R. China. cwchiang@whu.edu.cn aiwenlei@whu.edu.cn and National Research Center for Carbohydrate Synthesis, Jiangxi Normal University, Nanchang 330022, P. R. China.
authors.forename: Aiwen
authors.identifier: http://orcid.org/0000-0001-8417-3061
authors.initials: A
authors.lastname: Lei