title: Administration of Goji (Lycium chinense Mill.) Extracts Improves Erectile Function in Old Aged Rat Model.
abstract: OBJECTIVE
  This study investigated the effect of goji (Lycium chinense Mill.) on erectile dysfunction in old-aged rats.
  
  
  METHODS
  Twenty-four 18-month-old male Sprague-Dawley rats (defined as old-aged rats) were used. Treatment groups contained eight rats each: a control group, goji extract of 150 mg/kg/day group, and goji extract of 300 mg/kg/day group. Treatment was by orogastric tube once daily for 6 weeks. After 6 weeks of treatment, testes weight, serum testosterone, superoxide dismutase, nitric oxide (NO)-cyclic guanosine monophosphate (cGMP)-related parameters, intracavernous pressure/mean arterial pressure, and histological changes were examined.
  
  
  RESULTS
  Treatments with goji extracts increased serum testosterone level, increased the expression of endothelial NO synthase, neuronal NO synthase, and cGMP, improved the oxidative stress marker, and decreased corporal fibrosis.
  
  
  CONCLUSIONS
  Our results indicate that goji extract may have a positive effect on erectile dysfunction via its antioxidant effects.
authors.affiliation: Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Hyong Woo
authors.initials: HW
authors.lastname: Moon
authors.affiliation: Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Jung Woo
authors.initials: JW
authors.lastname: Park
authors.affiliation: Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Kyu Won
authors.initials: KW
authors.lastname: Lee
authors.affiliation: Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Hyun Cheol
authors.initials: HC
authors.lastname: Jeong
authors.affiliation: Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Jin Bong
authors.initials: JB
authors.lastname: Choi
authors.affiliation: Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Sae Woong
authors.initials: SW
authors.lastname: Choi
authors.affiliation: Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, Korea.|Catholic Integrative Medicine Research Institute, The Catholic University of Korea, Seoul, Korea.
authors.forename: Woong Jin
authors.initials: WJ
authors.lastname: Bae
authors.affiliation: Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Hyuk Jin
authors.initials: HJ
authors.lastname: Cho
authors.affiliation: Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: U Syn
authors.initials: US
authors.lastname: Ha
authors.affiliation: Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Sung Hoo
authors.initials: SH
authors.lastname: Hong
authors.affiliation: Biomix Inc., Goyang, Korea.
authors.forename: Jeong Ho
authors.initials: JH
authors.lastname: Geum
authors.affiliation: Biomix Inc., Goyang, Korea.
authors.forename: Seong Bin
authors.initials: SB
authors.lastname: Hong
authors.affiliation: Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, Korea.|Catholic Integrative Medicine Research Institute, The Catholic University of Korea, Seoul, Korea. ksw1227@catholic.ac.kr.
authors.forename: Sae Woong
authors.initials: SW
authors.lastname: Kim
keywords: Antioxidants; Erectile dysfunction; Testosterone