title: GSTP1c.313A>G polymorphism in Russian and Polish athletes.
abstract: TheGSTP1gene encodes glutathione S-transferase P1, which is a member of the glutathione S-transferases (GSTs), a family of enzymes playing an important role in detoxification and in the antioxidant defense system. There is some evidence indicating thatGSTP1c.313A>G polymorphism may be beneficial for exercise performance. Therefore, we decided to verify the association between the frequency ofGSTP1c.313A>G variants, physical performance, and athletes' status in two cohorts: in a group of Russian athletes (n= 507) and in an independent population of Polish athletes (n= 510) in a replication study. The initial association study conducted with the Russian athletes revealed that the frequency of the minor G allele was significantly higher in all athletes than in controls; that was confirmed in the replication study of Polish athletes. In the combined cohort, the differences between athletes (n= 1017) and controls (n= 1246) were even more pronounced (32.7 vs 25.0%,P< 0.0001). Our findings emphasize that the G allele of theGSTP1gene c.313A>G single nucleotide polymorphism is associated with improved endurance performance. These observations could support the hypothesis that theGSTP1G allele may improve exercise performance by better elimination of exercise-induced ROS.
authors.affiliation: Faculty of Tourism and Recreation, Gdansk University of Physical Education and Sport, Gdansk, Poland.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Zarebska
authors.affiliation: Faculty of Tourism and Recreation, Gdansk University of Physical Education and Sport, Gdansk, Poland.
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Jastrzebski
authors.affiliation: Laboratory of Molecular Genetics, Kazan State Medical University, Kazan, Russia.|Sport Technology Research Center, Volga Region State Academy of Physical Culture, Sport and Tourism, Kazan, Russia.
authors.forename: Ildus I
authors.initials: II
authors.lastname: Ahmetov
authors.affiliation: Department of Physiology, Institute of Sport - National Research Institute, Warsaw, Poland; piotr.zmijewski@insp.waw.pl.
authors.forename: Piotr
authors.initials: P
authors.lastname: Zmijewski
authors.affiliation: Centre for Human Functional and Structural Research, Faculty of Physical Education and Health Promotion, University of Szczecin, Szczecin, Poland.
authors.forename: Pawel
authors.initials: P
authors.lastname: Cieszczyk
authors.affiliation: Centre for Human Functional and Structural Research, Faculty of Physical Education and Health Promotion, University of Szczecin, Szczecin, Poland.
authors.forename: Agata
authors.initials: A
authors.lastname: Leonska-Duniec
authors.affiliation: Centre for Human Functional and Structural Research, Faculty of Physical Education and Health Promotion, University of Szczecin, Szczecin, Poland.
authors.forename: Marek
authors.initials: M
authors.lastname: Sawczuk
authors.affiliation: Centre for Human Functional and Structural Research, Faculty of Physical Education and Health Promotion, University of Szczecin, Szczecin, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Leznicka
authors.affiliation: Department of Oral Surgery, Pomeranian Medical University, Szczecin, Poland; and.
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Trybek
authors.affiliation: Laboratory of Molecular Genetics, Kazan State Medical University, Kazan, Russia.|Department of Biochemistry, Kazan Federal University, Kazan, Russia.
authors.forename: Ekaterina A
authors.initials: EA
authors.lastname: Semenova
authors.affiliation: Centre for Human Functional and Structural Research, Faculty of Physical Education and Health Promotion, University of Szczecin, Szczecin, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Maciejewska-Skrendo
mesh_terms: D056352:Athletes; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D051549:Glutathione S-Transferase pi / Q000235:genetics*; D006801:Humans; D008297:Male; D011044:Poland; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012426:Russia; D055815:Young Adult
chemical_list: C496556:GSTP1 protein, human; D051549:Glutathione S-Transferase pi
keywords: athletes; exercise performance; gene frequency/genetics; glutathione S-transferase; muscle; skeletal/metabolism