title: Drug-induced Liver Injury Associated with Mosapride Citrate: A Report of Two Cases.
abstract: We herein report two cases of drug-induced liver injury (DILI) due to mosapride. Case 1: A 78-year-old man was admitted with elevated transaminase levels. The cessation of mosapride led to the improvement of elevated liver enzyme levels. Case 2: A 54-year-old man was admitted with jaundice. Mosapride was discontinued immediately, and methylprednisolone was administered for acute liver failure. The patient's data showed improvement, and he was discharged on Day 32. In both cases, mosapride gave a positive response to a drug-induced lymphocyte stimulation test (DLST), and the patient's score based on the criteria for DILI was "highly probable".
authors.affiliation: The Center for Liver Disease, Hamanomachi Hospital, Japan.
authors.forename: Ayaka
authors.initials: A
authors.lastname: Sako
authors.forename: Sung Kwan
authors.initials: SK
authors.lastname: Bae
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Gushima
authors.forename: Junichi
authors.initials: J
authors.lastname: Motoshita
authors.forename: Shigemune
authors.initials: S
authors.lastname: Bekki
authors.forename: Seigo
authors.initials: S
authors.lastname: Abiru
authors.forename: Atsumasa
authors.initials: A
authors.lastname: Komori
authors.forename: Shinji
authors.initials: S
authors.lastname: Shimoda
authors.forename: Masahiro
authors.initials: M
authors.lastname: Ito
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yatsuhashi
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Takahashi
mesh_terms: D000368:Aged; D001549:Benzamides / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000209:etiology*; D006801:Humans; D007565:Jaundice / Q000188:drug therapy* / Q000209:etiology*; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use*; D008875:Middle Aged; D009025:Morpholines / Q000009:adverse effects*; D016896:Treatment Outcome
chemical_list: D001549:Benzamides; D009025:Morpholines; C062720:mosapride; D008775:Methylprednisolone