title: [Impacts of airborne particulate matter and its components on respiratory system health].
abstract: Nowadays, particulate air pollution has been a global environmental problem. Numerous studies has shown that long-term exposure to high level of airborne particulate matter (PM) can damage human health. Respiratory system, as a direct portal to contact with particulate matter, can be more susceptible to airborne particulates. Summarizing latest five-year epidemiological research, the present review is focused on the effects of PM on respiratory system health in different age groups. In detail, we investigated the harmful effect of PM, or its components on three common respiratory diseases, including lung function decline, chronic obstructive pulmonary disease (COPD) and asthma. The result showed that, to a certain degree, PM could induce the decline of lung function, the development and the exacerbation of COPD and asthma by oxidative stress and inflammatory reaction. And it may prompt that exposure to PM can be an improtant risk factor for the respiratory system health.
authors.affiliation: Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
authors.forename: L M
authors.initials: LM
authors.lastname: Cao
authors.forename: Y
authors.initials: Y
authors.lastname: Zhou
authors.forename: Z
authors.initials: Z
authors.lastname: Zhang
authors.forename: W W
authors.initials: WW
authors.lastname: Sun
authors.forename: G
authors.initials: G
authors.lastname: Mu
authors.forename: W H
authors.initials: WH
authors.lastname: Chen
mesh_terms: D000393:Air Pollutants; D000397:Air Pollution / Q000009:adverse effects*; D001249:Asthma / Q000209:etiology* / Q000503:physiopathology; D016021:Epidemiologic Studies; D006801:Humans; D008168:Lung / Q000187:drug effects / Q000503:physiopathology*; D018384:Oxidative Stress; D052638:Particulate Matter / Q000009:adverse effects*; D029424:Pulmonary Disease, Chronic Obstructive / Q000209:etiology* / Q000503:physiopathology; D012137:Respiratory System / Q000503:physiopathology*; D012307:Risk Factors
chemical_list: D000393:Air Pollutants; D052638:Particulate Matter