title: Interference of Vaccine Derived Polio Viruses with Diagnosis of Enteroviral Diseases in Neonatal Period.
abstract: BACKGROUND
  Enteroviruses (EV) are a common cause of neonatal sepsis especially at the junction of summer and fall.
  
  
  OBJECTIVE
  This study was planned to find the frequency of Enteroviral (EV) sepsis among neonates with clinical sepsis.
  
  
  METHODS
  This is a prospective descriptive study. Rectal and pharyngeal swab samples were taken from all neonates with clinical sepsis and a control group of neonates with simple jaundice. EV was confirmed by both cell culture and RT-PCR. Anti polio antiserum was used to differentiate Polioviruses from Non Polio EVs (NPEV).
  
  
  RESULTS
  We had 67 neonates with clinical sepsis and 31 cases of simple jaundice during 105 days. NPEVs were isolated from 2 cases (2.9%) of the sepsis arm and one neonate (3.2%) of the jaundice group. Polio virus was isolated from 16.2% and 15.3% of OPV recipients in the sepsis and jaundice group respectively.
  
  
  CONCLUSIONS
  Enteroviruses were not a common cause for neonatal sepsis in Nemazi hospital at the time of this study. OPV vaccinated neonates commonly pass the vaccine virus in their pharynx and stool which can be mistaken with NPEV.
authors.affiliation: Associate Professor, Department of Paediatrics, Mashhad University of Medical Sciences, Imam Reza Hospital , Mashhad, Iran .
authors.forename: Mohammad Saeed
authors.initials: MS
authors.lastname: Sasan
authors.affiliation: Assistant Professor, Department of Paediatrics, Mashhad University of Medical Sciences, Imam Reza Hospital , Mashhad, Iran .
authors.forename: Alireza Ataei
authors.initials: AA
authors.lastname: Nakhaei
authors.affiliation: Professor, Department of Paediatrics, Shiraz University of Medical Sciences, Namazi General Hospital , Shiraz, Iran .
authors.forename: Abdolvahab
authors.initials: A
authors.lastname: Alborzi
authors.affiliation: Professor, Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Namazi General Hospital , Shiraz, Iran .
authors.forename: Mazyar
authors.initials: M
authors.lastname: Ziyaeyan
keywords: Enterovirus; Neonate; Sepsis