title: Higher scores in the extraversion personality trait are associated with a functional polymorphism in the PER3 gene in healthy subjects.
abstract: A polymorphism in the PER3 (period circadian clock 3) gene has been associated with neuropsychiatric disorders and endophenotypes. We evaluated the possible association of personality domains with the PER3 polymorphism in a sample of healthy subjects: 271 individuals were evaluated with the Big Five Inventory and genotyped for the PER3 Variable Number Tandem Repeat (VNTR) polymorphism. We found a significant association between the PER3 polymorphism and the extraversion personality trait (p = 0.0093). The 5/5 genotype carriers showed higher scores for extraversion. This is the first time that a significant association between the PER3 VNTR polymorphism and extraversion is reported.
authors.affiliation: a Laboratory of NeuroPsychiatric Genetics, Biomedical Sciences Research Group, School of Medicine , Universidad Antonio Nariño , Bogotá , Colombia.
authors.forename: Karen M
authors.initials: KM
authors.lastname: Jiménez
authors.affiliation: a Laboratory of NeuroPsychiatric Genetics, Biomedical Sciences Research Group, School of Medicine , Universidad Antonio Nariño , Bogotá , Colombia.
authors.forename: Angela J
authors.initials: AJ
authors.lastname: Pereira-Morales
authors.affiliation: a Laboratory of NeuroPsychiatric Genetics, Biomedical Sciences Research Group, School of Medicine , Universidad Antonio Nariño , Bogotá , Colombia.
authors.forename: Diego A
authors.initials: DA
authors.lastname: Forero
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D002940:Circadian Rhythm / Q000235:genetics; D003105:Colombia; D005120:Extraversion, Psychological; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005838:Genotype; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D008875:Middle Aged; D018598:Minisatellite Repeats; D056950:Period Circadian Proteins / Q000235:genetics*; D010551:Personality; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D012890:Sleep / Q000235:genetics; D055815:Young Adult
chemical_list: C512644:PER3 protein, human; D056950:Period Circadian Proteins
keywords: PER3 gene; circadian genes; extraversion; personality traits; psychiatric genetics