title: Pulmonary Infection Is an Independent Risk Factor for Long-Term Mortality and Quality of Life for Sepsis Patients.
abstract: Background.Long-term outcomes (mortality and health-related quality of life) of sepsis have risen as important indicators for health care. Pulmonary infection and abdominal infection are the leading causes of sepsis. However, few researches about long-term outcomes focused on the origin of sepsis. Here we aim to study the clinical differences between pulmonary-sepsis and abdominal-sepsis and to investigate whether different infection foci were associated with long-term outcomes.Methods.Patients who survived after hospital discharge were followed up by telephone interview. Quality of life (QoL) was assessed using the EuroQol 5-dimension (EQ5D) questionnaire.Results.Four hundred and eighty-three sepsis patients were included, 272 (56.3%) had pulmonary-sepsis, and 180 (37.3%) had abdominal-sepsis. The overall ICU and one-year mortality rates of the cohort were 17.8% and 36.1%, respectively. Compared with abdominal-sepsis, pulmonary-sepsis patients had older age, higher APACHE II, higher ICU mortality (31.7% versus 12.6%), and one-year mortality (45.4% versus 24.4%), together with worse QoL. Age, septic shock, acute renal failure, fungus infection, anion gap, and pulmonary infection were predictors for one-year mortality and pulmonary infection was a risk factor for poor QoL.Conclusions.Pulmonary-sepsis showed worse outcome than abdominal-sepsis. Pulmonary infection is a risk factor for one-year mortality and QoL after sepsis.
authors.affiliation: Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: He
authors.affiliation: Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Xue-Lian
authors.initials: XL
authors.lastname: Liao
authors.affiliation: Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Zhi-Chao
authors.initials: ZC
authors.lastname: Xie
authors.affiliation: Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Li
authors.initials: L
authors.lastname: Han
authors.affiliation: Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Xiao-Lei
authors.initials: XL
authors.lastname: Yang
authors.affiliation: Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Yan
authors.identifier: 0000-0003-4968-1217
authors.initials: Y
authors.lastname: Kang
mesh_terms: D015331:Cohort Studies; D003710:Demography; D005260:Female; D006801:Humans; D007362:Intensive Care Units / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011788:Quality of Life; D012044:Regression Analysis; D012141:Respiratory Tract Infections / Q000150:complications* / Q000401:mortality*; D012307:Risk Factors; D018805:Sepsis / Q000150:complications* / Q000401:mortality*; D011795:Surveys and Questionnaires; D016019:Survival Analysis