title: Challenges and Opportunities in the Development of HIV Medications in Pediatric Patients.
abstract: Successful management of pediatric HIV disease requires high therapeutic efficacy and adherence, which can be achieved by providing affordable, easy to store, and palatable antiretrovirals. Current challenges in pediatric antiretroviral drug development include poor palatability, large pill size, limited oral liquid formulations, and few incentives for development by drug manufacturers as the number of children with HIV continues to decline due to successful worldwide preventive interventions and improved access to antiretrovirals. This article summarizes the various challenges and opportunities with current pediatric antiretrovirals, recent and ongoing trials, new formulations, and suggestions that may expedite and provide incentives for the development of suitable pediatric formulations.
authors.affiliation: Division of Pediatric Infectious Diseases, Children's National Health System, 111 Michigan Ave NW, Washington, 20310, DC, USA. gdubrocq@childrensnational.org.|Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA. gdubrocq@childrensnational.org.
authors.forename: Gueorgui
authors.initials: G
authors.lastname: Dubrocq
authors.affiliation: Division of Pediatric Infectious Diseases, Children's National Health System, 111 Michigan Ave NW, Washington, 20310, DC, USA.|Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
authors.forename: Natella
authors.initials: N
authors.lastname: Rakhmanina
authors.affiliation: Office of HIV/AIDS, United States Agency for International Development, Washington, DC, USA.
authors.forename: B Ryan
authors.initials: BR
authors.lastname: Phelps
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use*; D002648:Child; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D010372:Pediatrics
chemical_list: D019380:Anti-HIV Agents