title: Self-assembled peptide nanomaterials for biomedical applications: promises and pitfalls.
abstract: Over the last several decades, a great number of advances have been made in the area of self-assembled supramolecules for regenerative medicine. Such advances have involved the design, preparation, and characterization of brand new self-assembled peptide nanomaterials for a variety of applications. Among all biomolecules considered for self-assembly applications, peptides have attracted a great deal of attention as building blocks for bottom-up fabrication, due to their versatility, ease of manufacturing, low costs, tunable structures, and versatile properties. Herein, some of the more exciting new designs of self-assembled peptides and their associated unique features are reviewed and several promising applications of how self-assembled peptides are advancing drug delivery, tissue engineering, antibacterial therapy, and biosensor device applications are highlighted.
authors.affiliation: Wenzhou Institute of Biomaterials and Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China; Department of Chemical Engineering, Northeastern University, Boston, MA, USA.
authors.forename: Linlin
authors.initials: L
authors.lastname: Sun
authors.affiliation: Pharmaceutical Research Institute, China Pharmaceutical University, Nanjing, People's Republic of China.
authors.forename: Chunli
authors.initials: C
authors.lastname: Zheng
authors.affiliation: Wenzhou Institute of Biomaterials and Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China; Department of Chemical Engineering, Northeastern University, Boston, MA, USA; Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah, Saudi Arabia.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Webster
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry; D015374:Biosensing Techniques; D016503:Drug Delivery Systems; D006801:Humans; D051379:Mice; D050997:Nanomedicine / Q000379:methods* / Q000639:trends; D049329:Nanostructures / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D051381:Rats; D044968:Regenerative Medicine / Q000379:methods*; D023822:Tissue Engineering / Q000379:methods*
chemical_list: D000900:Anti-Bacterial Agents; D010455:Peptides
keywords: antibacterial therapy; biomedical applications; biosensor devices; drug delivery; peptides; self-assembly