title: A DBU-catalyzed Michael-Pinner-isomerization cascade reaction of 3-hydroxyoxindoles with isatylidene malononitriles: access to highly functionalized bispirooxindoles containing a fully substituted dihydrofuran motif.
abstract: The first DBU-catalyzed Michael/Pinner/isomerization cascade reaction of 3-hydrooxindoles with isatylidene malononitriles was developed, and the corresponding highly functionalized bispirooxindoles containing a fully substituted dihydrofuran motif were obtained in up to 92% yields. This protocol also provides an efficient method for the synthesis of an α-cyano-γ-butyrolactone bispirooxindole. In addition, a one-pot three-component cascade reaction was conducted. Also, the asymmetric version of the cascade reaction was achieved.
authors.affiliation: College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, China. wangqilin@henu.edu.cn buzhanwei@henu.edu.cn.
authors.forename: Yan-Shuo
authors.initials: YS
authors.lastname: Zhu
authors.affiliation: College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, China. wangqilin@henu.edu.cn buzhanwei@henu.edu.cn.
authors.forename: Wen-Bo
authors.initials: WB
authors.lastname: Wang
authors.affiliation: College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, China. wangqilin@henu.edu.cn buzhanwei@henu.edu.cn.
authors.forename: Bei-Bei
authors.initials: BB
authors.lastname: Yuan
authors.affiliation: College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, China. wangqilin@henu.edu.cn buzhanwei@henu.edu.cn.
authors.forename: Ya-Ning
authors.initials: YN
authors.lastname: Li
authors.affiliation: College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, China. wangqilin@henu.edu.cn buzhanwei@henu.edu.cn.
authors.forename: Qi-Lin
authors.identifier: http://orcid.org/0000-0003-4637-0392
authors.initials: QL
authors.lastname: Wang
authors.affiliation: College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, China. wangqilin@henu.edu.cn buzhanwei@henu.edu.cn.
authors.forename: Zhan-Wei
authors.initials: ZW
authors.lastname: Bu