title: Subcellular Redox Targeting: Bridging in Vitro and in Vivo Chemical Biology.
abstract: Networks of redox sensor proteins within discrete microdomains regulate the flow of redox signaling. Yet, the inherent reactivity of redox signals complicates the study of specific redox events and pathways by traditional methods. Herein, we review designer chemistries capable of measuring flux and/or mimicking subcellular redox signaling at the cellular and organismal level. Such efforts have begun to decipher the logic underlying organelle-, site-, and target-specific redox signaling in vitro and in vivo. These data highlight chemical biology as a perfect gateway to interrogate how nature choreographs subcellular redox chemistry to drive precision redox biology.
authors.affiliation: Department of Chemistry & Chemical Biology, Cornell University , Ithaca, New York 14850, United States.
authors.forename: Marcus J C
authors.initials: MJ
authors.lastname: Long
authors.affiliation: Department of Chemistry & Chemical Biology, Cornell University , Ithaca, New York 14850, United States.
authors.forename: Jesse R
authors.initials: JR
authors.lastname: Poganik
authors.affiliation: Department of Chemistry & Chemical Biology, Cornell University , Ithaca, New York 14850, United States.
authors.forename: Souradyuti
authors.initials: S
authors.lastname: Ghosh
authors.affiliation: Department of Chemistry & Chemical Biology, Cornell University , Ithaca, New York 14850, United States.|Department of Biochemistry, Weill Cornell Medicine , New York, New York 10065, United States.
authors.forename: Yimon
authors.identifier: 0000-0002-1256-4159
authors.initials: Y
authors.lastname: Aye
mesh_terms: D066298:In Vitro Techniques; D010084:Oxidation-Reduction; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction; D013347:Subcellular Fractions / Q000378:metabolism*
chemical_list: D017382:Reactive Oxygen Species