title: The Role of BRCA2 Mutation Status as Diagnostic, Predictive, and Prognosis Biomarker for Pancreatic Cancer.
abstract: Pancreatic cancer is one of the deadliest cancers worldwide, and life expectancy after diagnosis is often short. Most pancreatic tumours appear sporadically and have been highly related to habits such as cigarette smoking, high alcohol intake, high carbohydrate, and sugar consumption. Other observational studies have suggested the association between pancreatic cancer and exposure to arsenic, lead, or cadmium. Aside from these factors, chronic pancreatitis and diabetes have also come to be considered as risk factors for these kinds of tumours. Studies have found that 10% of pancreatic cancer cases arise from an inherited syndrome related to some genetic alterations. One of these alterations includes mutation inBRCA2gene.BRCA2mutations impair DNA damage response and homologous recombination by direct regulation of RAD51. In light of these findings that link genetic factors to tumour development, DNA damage agents have been proposed as target therapies for pancreatic cancer patients carryingBRCA2mutations. Some of these drugs include platinum-based agents and PARP inhibitors. However, the acquired resistance to PARP inhibitors has created a need for new chemotherapeutic strategies to targetBRCA2.The present systematic review collects and analyses the role ofBRCA2alterations to be used in early diagnosis of an inherited syndrome associated with familiar cancer and as a prognostic and predictive biomarker for the management of pancreatic cancer patients.
authors.affiliation: Translational Oncology Division, Oncohealth Institute, Health Research Institute, University Hospital Fundación Jiménez Díaz-UAM, Madrid, Spain.
authors.forename: Javier
authors.identifier: 0000-0001-9007-828X
authors.initials: J
authors.lastname: Martinez-Useros
authors.affiliation: Translational Oncology Division, Oncohealth Institute, Health Research Institute, University Hospital Fundación Jiménez Díaz-UAM, Madrid, Spain.
authors.forename: Jesus
authors.initials: J
authors.lastname: Garcia-Foncillas
mesh_terms: D024682:BRCA2 Protein / Q000235:genetics*; D014408:Biomarkers, Tumor / Q000235:genetics*; D055088:Early Detection of Cancer; D005260:Female; D020022:Genetic Predisposition to Disease; D018095:Germ-Line Mutation; D006801:Humans; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D011379:Prognosis; D012307:Risk Factors
chemical_list: D024682:BRCA2 Protein; C551750:BRCA2 protein, human; D014408:Biomarkers, Tumor