title: Coenzyme Q10 and Oxidative Stress: Inflammation Status in Hepatocellular Carcinoma Patients after Surgery.
abstract: (1) Background: Hepatocellular carcinoma (HCC) is the second leading cause of cancer deaths worldwide, and surgical resection is the main treatment for HCC. To date, no published study has examined the status of coenzyme Q10 in patients with HCC after surgery. Thus, the purpose of this study was to investigate the correlations between the level of coenzyme Q10, oxidative stress, and inflammation in patients with HCC after surgery; (2) Methods: 71 primary HCC patients were recruited. Levels of coenzyme Q10, vitamin E, oxidative stress (malondialdehyde), antioxidant enzymes activity (superoxidase dismutase, catalase, and glutathione peroxidase), and inflammatory markers (high sensitivity C-reactive protein; tumor necrosis factor-α; and interleukin-6) were measured; (3) Results: Patients with HCC had a significantly lower levels of coenzyme Q10 (p= 0.01) and oxidative stress (p< 0.01), and significantly higher levels of antioxidant enzymes activities and inflammation after surgery (p< 0.05). The level of coenzyme Q10 was significantly positively correlated with antioxidant capacity (vitamin E and glutathione peroxidase activity) and negatively correlated with inflammation markers after surgery; (4) Conclusion: Hepatocarcinogenesis is associated with oxidative stress, and coenzyme Q10 may be considered an antioxidant therapy for patients with HCC, particularly those with higher inflammation after surgery.
authors.affiliation: Division of General Surgery, Department of Surgery, Taichung Veterans General Hospital, Taichung 40705, Taiwan. langhsky@vghtc.gov.tw.|Department of Nutrition, Chung Shan Medical University, Taichung 40201, Taiwan. langhsky@vghtc.gov.tw.
authors.forename: Hsiao-Tien
authors.initials: HT
authors.lastname: Liu
authors.affiliation: Division of General Surgery, Department of Surgery, Taichung Veterans General Hospital, Taichung 40705, Taiwan. sbc@vghtc.gov.tw.|Department of Nutrition, Chung Shan Medical University, Taichung 40201, Taiwan. sbc@vghtc.gov.tw.|School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan. sbc@vghtc.gov.tw.
authors.forename: Shao-Bin
authors.initials: SB
authors.lastname: Cheng
authors.affiliation: Department of Nutrition, Chung Shan Medical University, Taichung 40201, Taiwan. ych@csmu.edu.tw.
authors.forename: Yi-Chia
authors.initials: YC
authors.lastname: Huang
authors.affiliation: Department of Nutrition, Chung Shan Medical University, Taichung 40201, Taiwan. scorpio5220@hotmail.com.
authors.forename: Yin-Tzu
authors.initials: YT
authors.lastname: Huang
authors.affiliation: Department of Nutrition, Chung Shan Medical University, Taichung 40201, Taiwan. apt810@csmu.edu.tw.|Department of Nutrition, Chung Shan Medical University Hospital, Taichung 40201, Taiwan. apt810@csmu.edu.tw.
authors.forename: Ping-Ting
authors.initials: PT
authors.lastname: Lin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D006528:Carcinoma, Hepatocellular / Q000097:blood* / Q000601:surgery; D003404:Creatinine / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D007249:Inflammation / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood; D016014:Linear Models; D008113:Liver Neoplasms / Q000097:blood* / Q000601:surgery; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress; D013482:Superoxide Dismutase / Q000097:blood; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000097:blood; D014810:Vitamin E / Q000097:blood; D055815:Young Adult
chemical_list: D001786:Blood Glucose; C508600:IL6 protein, human; D015850:Interleukin-6; D017392:Thiobarbituric Acid Reactive Substances; D014409:Tumor Necrosis Factor-alpha; D014451:Ubiquinone; D014810:Vitamin E; D008315:Malondialdehyde; D002097:C-Reactive Protein; D003404:Creatinine; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D001219:Aspartate Aminotransferases; C024989:coenzyme Q10
keywords: coenzyme Q10; hepatocellular carcinoma; inflammation; oxidative stress; surgery