title: In Vivo Radionuclide Generators for Diagnostics and Therapy.
abstract: In vivo radionuclide generators make complex combinations of physical and chemical properties available for medical diagnostics and therapy. Perhaps the best-known in vivo generator is212Pb/212Bi, which takes advantage of the extended half-life of212Pb to execute a targeted delivery of the therapeutic short-livedα-emitter212Bi. Often, as in the case of81Rb/81Kr, chemical changes resulting from the transmutation of the parent are relied upon for diagnostic value. In other instances such as with extended alpha decay chains, chemical changes may lead to unwanted consequences. This article reviews some common and not-so-common in vivo generators with the purpose of understanding their value in medicine and medical research. This is currently relevant in light of a recent push for alpha emitters in targeted therapies, which often come with extended decay chains.
authors.affiliation: Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, Copenhagen, Denmark; Cluster for Molecular Imaging, Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Patricia E
authors.initials: PE
authors.lastname: Edem
authors.affiliation: Center for Nuclear Technologies, Technical University of Denmark, Roskilde, Denmark.
authors.forename: Jesper
authors.initials: J
authors.lastname: Fonslet
authors.affiliation: Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, Copenhagen, Denmark; Cluster for Molecular Imaging, Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Andreas
authors.initials: A
authors.lastname: Kjær
authors.affiliation: Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, Copenhagen, Denmark; Cluster for Molecular Imaging, Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Matthias
authors.initials: M
authors.lastname: Herth
authors.affiliation: Center for Nuclear Technologies, Technical University of Denmark, Roskilde, Denmark; Department of Chemistry, Michigan State University, East Lansing, MI, USA; Facility for Rare Isotope Beams, Michigan State University, East Lansing, MI, USA.
authors.forename: Gregory
authors.identifier: 0000-0003-1189-7311
authors.initials: G
authors.lastname: Severin