title: [Priorities of clinical drug trials in Brazil and neglected diseases of poverty].
abstract: OBJECTIVE
  To identify clinical drug trials performed in Brazil between 2012 and 2015, with emphasis on those focusing on neglected diseases of poverty.
  
  
  METHODS
  Two clinical trial registries, ReBEC (Brazilian registry) and ClinicalTrials.gov were surveyed. The following aspects were investigated: distribution of clinical trials in relation to the burden of disease in Brazil, distribution of trials regarding their focus on diseases of poverty vs. diseases not linked to poverty, phase of trials, performing institution, and type of funding (private, public, or mixed).
  
  
  RESULTS
  The search revealed 866 eligible trials, 88 registered in ReBEC and 778 in ClinicalTrials.gov. Of these, 73 (8.5%) were phase I trials, 610 (70.5%) were phase II and III trials, and 183 (21%) were phase IV trials. There were 38 trials (4%) focusing on neglected diseases of poverty. Regarding the burden of disease, 734 (84.8%) trials focused on noncommunicable diseases, which in fact represent the largest burden of disease in Brazil. Most trials were carried out by pharmaceutical companies (55.3%), with predominance of private funding (57.1%); however, if only the diseases of poverty are considered, 63.1% were financed by public resources.
  
  
  CONCLUSIONS
  The clinical drug trials carried out in Brazil in the study period are in agreement with the proportional burden of disease for the country. However, the neglected diseases of poverty were not prioritized. More effective action is necessary to redirect clinical research on drug development to meet national needs.
authors.affiliation: Universidade de Brasília, Faculdade de Saúde, Brasília (DF), Brasil.
authors.forename: Rafael Santos
authors.initials: RS
authors.lastname: Santana
authors.affiliation: Universidade Federal de Santa Catarina, Departamento de Ciências Farmacêuticas, Florianópolis (SC), Brasil.
authors.forename: Silvana Nair
authors.initials: SN
authors.lastname: Leite
mesh_terms: D001938:Brazil; D002986:Clinical Trials as Topic / Q000706:statistics & numerical data*; D004345:Drug Industry; D006801:Humans; D058069:Neglected Diseases / Q000188:drug therapy*; D000073296:Noncommunicable Diseases / Q000188:drug therapy; D011203:Poverty; D012042:Registries / Q000706:statistics & numerical data*; D012109:Research Support as Topic