title: Primary cutaneous B-cell lymphomas with large cell predominance-primary cutaneous follicle center lymphoma, diffuse large B-cell lymphoma, leg type and intravascular large B-cell lymphoma.
abstract: In this review, we present clinical features and detailed histopathologic, immunologic, and molecular information regarding primary cutaneous follicle center lymphoma and primary cutaneous diffuse large B-cell lymphoma, leg type which together represent two of the three most common types of primary cutaneous B-cell lymphoma recognized in the current WHO classification system.1,2Overall, B-cell lymphomas represent 19-27% of primary cutaneous lymphomas in most large European and American studies3-6and together, primary cutaneous follicle center lymphoma and primary cutaneous diffuse large B-cell lymphoma, leg type account for approximately 2/3 to ¾ of these cases.5,7-11Both subtypes can contain a high content of large B-lymphocytes, although most cases of primary cutaneous follicle center lymphomas exhibit a range in cell size and cytology. Intravascular large B-cell lymphoma, a less commonly-encountered EBV-negative primary cutaneous B-cell lymphoma composed of large cells, will be more briefly discussed in this report as well.
authors.affiliation: Department of Pathology, University of California San Francisco, USA.
authors.forename: Charity B
authors.initials: CB
authors.lastname: Hope
authors.affiliation: Department of Pathology, University of California San Francisco, USA; Department of Dermatology, University of California San Francisco, USA. Electronic address: laura.pincus@ucsf.edu.
authors.forename: Laura B
authors.initials: LB
authors.lastname: Pincus
mesh_terms: D006801:Humans; D007866:Leg; D008224:Lymphoma, Follicular / Q000175:diagnosis / Q000235:genetics / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis / Q000235:genetics / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000473:pathology; D019043:Vascular Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000473:pathology
keywords: Intravascular large B-cell lymphoma; Primary cutaneous B-cell lymphoma; Primary cutaneous diffuse large B-cell lymphoma, leg type; Primary cutaneous follicle center lymphoma