title: Prognostic factors of hepatocellular carcinoma patients with portal vein tumor thrombosis treated with transcatheter arterial chemoembolization.
abstract: OBJECTIVE
  To investigate the factors that influence survival of hepatocellular carcinoma (HCC) patients with portal vein tumor thrombosis (PVTT) following transarterial chemoembolization (TACE).
  
  
  METHODS
  Retrospectively enrolled HCC patients with PVTT (n = 57). Patients received TACE, and the local tumor response was evaluated by modified response evaluation criteria in solid tumor (mRECIST). Overall survival and disease progression were evaluated using Kaplan-Meier survival curves. Prognostic factors were determined by multivariate Cox regression analysis.
  
  
  RESULTS
  Following TACE, the median survival times was 8.3 months in HCC patients with PVTT. The median survival time was 3.1 months for patients with progressive disease following TACE and was 11.3 months for patients with complete response or partial response. The one-year rate of survival for patients with progressive disease was 5.0% and was lower than in patients with complete response or partial response (20.0%, P < 0.001). Multivariate analysis indicated that the presence of ascites, arteriovenous fistula and TACE response were significant factors for prognosis. The presence of early (<2 weeks) or late (≥2 weeks) PVTT was not a prognostic factor.
  
  
  CONCLUSIONS
  Our study indicates that TACE is feasible and potentially efficacious in HCC patients with PVTT, and identifies factors that may predict the prognosis of these patients.
authors.affiliation: Department of Radiology, China Medical University Shengjing Hospital, Shenyang, Liaoning Province, China.
authors.forename: Hongyuan
authors.initials: H
authors.lastname: Liang
authors.affiliation: Department of Radiology, China Medical University Shengjing Hospital, Shenyang, Liaoning Province, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Cui
authors.affiliation: Department of Radiology, China Medical University Shengjing Hospital, Shenyang, Liaoning Province, China.
authors.forename: Qiyong
authors.initials: Q
authors.lastname: Guo
authors.affiliation: Department of Radiology, China Medical University Shengjing Hospital, Shenyang, Liaoning Province, China.
authors.forename: Xiaonan
authors.initials: X
authors.lastname: Mao
authors.affiliation: Department of Radiology, China Medical University Shengjing Hospital, Shenyang, Liaoning Province, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Wen
authors.affiliation: Department of Radiology, China Medical University Shengjing Hospital, Shenyang, Liaoning Province, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Sun
authors.affiliation: Department of Radiology, China Medical University Shengjing Hospital, Shenyang, Liaoning Province, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Shan
authors.affiliation: Department of Radiology, China Medical University Shengjing Hospital, Shenyang, Liaoning Province, China.
authors.forename: Zaiming
authors.initials: Z
authors.lastname: Lu
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000150:complications* / Q000473:pathology; D016461:Chemoembolization, Therapeutic / Q000379:methods*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011169:Portal Vein / Q000473:pathology*; D011379:Prognosis; D012189:Retrospective Studies; D016896:Treatment Outcome
keywords: PVTT; hepatocellular carcinoma; portal vein tumor thrombosis; prognostic factor; survival