title: Polymorphism-801G/A in the 3'-untranslated region of CXCL12 is not associated with preeclampsia in Chinese Han population.
abstract: OBJECTIVE
  We investigated whether the CXCL12-801G/A polymorphism was associated with preeclampsia (PE) susceptibility in a Chinese Han population.
  
  
  METHODS
  We examined 912 PE women and 1025 controls for the CXCL12-801G/A polymorphism by polymerase chain reaction (PCR) and correlations with clinical characteristics were examined.
  
  
  RESULTS
  No significant differences in genotypic and allelic frequencies of CXCL12-G801A were found between cases and controls (genotype: χ2= 2.095, p = 0.351; allele: χ2= 1.713, p = 0.191). There were also no significant differences between early/late-onset or mild/severe PE and control groups.
  
  
  CONCLUSIONS
  The results indicate that 801G/A in CXCL12 may not play a major role in pathogenesis of PE in a Chinese Han population.
authors.affiliation: a Department of Obstetrics , The Affiliated Hospital of Qingdao University , Qingdao , China.
authors.forename: Jine
authors.initials: J
authors.lastname: Xu
authors.affiliation: b Department of Biology , The First Senior High School of Chengwu , Heze , China.
authors.forename: Kai
authors.initials: K
authors.lastname: Chen
authors.affiliation: c Department of Medical Specimen Collection , The Affiliated Hospital of Qingdao University , Qingdao , China.
authors.forename: Aiqin
authors.initials: A
authors.lastname: Li
authors.affiliation: d Prenatal Diagnosis Center , The Affiliated Hospital of Qingdao University , Qingdao , China.
authors.forename: Mingzhen
authors.initials: M
authors.lastname: Guo
authors.affiliation: d Prenatal Diagnosis Center , The Affiliated Hospital of Qingdao University , Qingdao , China.
authors.forename: Jingli
authors.initials: J
authors.lastname: Wang
authors.affiliation: d Prenatal Diagnosis Center , The Affiliated Hospital of Qingdao University , Qingdao , China.
authors.forename: Shiguo
authors.initials: S
authors.lastname: Liu
authors.affiliation: e Department of Biology , The Medical College of Qingdao University , Qingdao , China.
authors.forename: Xiuhai
authors.initials: X
authors.lastname: Wang
mesh_terms: D020413:3' Untranslated Regions; D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D054377:Chemokine CXCL12 / Q000235:genetics*; D002681:China; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D055815:Young Adult
chemical_list: D020413:3' Untranslated Regions; C515255:CXCL12 protein, human; D054377:Chemokine CXCL12
keywords: CXCL12; pathogenesis; polymorphism; preeclampsia; susceptibility