title: The Development of Urease Inhibitors: What Opportunities Exist for Better Treatment of Helicobacter pylori Infection in Children?
abstract: Stomach infection withHelicobacter pylori(H. pylori)causes severe gastroduodenal diseases in a large number of patients worldwide. TheH. pyloriinfection breaks up in early childhood, persists lifelong if not treated, and is associated with chronic gastritis and an increased risk of peptic ulcers and gastric cancer. In recent years, the problem of drug-resistant strains has become a global concern that makes the treatment more complicated and the infection persistent at higher levels when the antibiotic treatment is stopped. Such problems have led to the development of new strategies to eradicate anH. pyloriinfection. Currently, one of the most important strategies for the treatment ofH. pyloriinfection is the use of urease inhibitors. Despite the fact that large numbers of molecules have been shown to exert potent inhibitory activity againstH. pyloriurease, most of them were prevented from being used in vivo and in clinical trials due to their hydrolytic instability, toxicity, and appearance of undesirable side effects. Therefore, it is crucial to focus attention on the available opportunities for the development of urease inhibitors with suitable pharmacokinetics, high hydrolytic stability, and free toxicological profiles. In this commentary, we aim to afford an outline on the current status of the use of urease inhibitors in the treatment of anH. pyloriinfection, and to discuss the possibility of their development as effective drugs in clinical trials.
authors.affiliation: Department of Natural Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackého tř. 1946/1, 61242 Brno, Czech Republic. sherif.hassan@seznam.cz.|Department of Applied Ecology, Faculty of Environmental Sciences, Czech University of Life Sciences Prague, Kamýcká 129, 165 21 Praha 6-Suchdol, Czech Republic. sherif.hassan@seznam.cz.
authors.forename: Sherif T S
authors.initials: ST
authors.lastname: Hassan
authors.affiliation: Museum of the Brno Region, Museum of Literature in Moravia, Porta Coeli 1001, 66602 Předklášteří, Czech Republic. sudomova@post.cz.
authors.forename: Miroslava
authors.initials: M
authors.lastname: Šudomová
keywords: Helicobacter pylori (H. pylori) infection; children; drug development; pharmacokinetics; urease inhibitors