title: Synthesis and characterization of thermosensitive poly(N-vinylcaprolactam)-g-collagen.
abstract: In this study, we synthesized poly(N-vinylcaprolactam)-g-collagen (PNVCL-g-Col) by grafting collagen with carboxyl group-terminated thermosensitive PNVCL-COOH. The resulting biopolymer was evaluated for its structural, thermal, and rheological properties. Aqueous solutions of PNVCL-g-Col exhibited a temperature-dependent phase transition around human physiological temperature (at ∼38.5 °C), and temperature-dependent tunability. PNVCL-g-Col exhibited temperature-dependent release of the model drugs, lidocaine hydrochloride and bovine serum albumin. Thus, PNVCL-g-Col biopolymer may have wide potential use in various biomedical applications, including controlled release and tissue engineering.
authors.affiliation: a Tissue Engineering, Biomaterials and Nanobiotechnology Laboratory , Ankara University Faculty of Science, and Ankara University Stem Cell Institute , Ankara , Turkey.
authors.forename: Serap
authors.initials: S
authors.lastname: Durkut
authors.affiliation: a Tissue Engineering, Biomaterials and Nanobiotechnology Laboratory , Ankara University Faculty of Science, and Ankara University Stem Cell Institute , Ankara , Turkey.
authors.forename: Yaşar Murat
authors.initials: YM
authors.lastname: Elçin
mesh_terms: D000818:Animals; D002209:Caprolactam / Q000031:analogs & derivatives* / Q000737:chemistry; D002417:Cattle; D060326:Chemistry Techniques, Synthetic; D003094:Collagen / Q000737:chemistry*; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry*; D065546:Drug Liberation; D006801:Humans; D008012:Lidocaine / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D012212:Rheology; D012710:Serum Albumin, Bovine / Q000737:chemistry; D013696:Temperature; D014867:Water / Q000737:chemistry
chemical_list: D004337:Drug Carriers; D011108:Polymers; D014867:Water; C086861:poly-N-vinylcaprolactam; D012710:Serum Albumin, Bovine; D002209:Caprolactam; D003094:Collagen; D008012:Lidocaine
keywords: LCST; Thermosensitive polymer; biopolymer; controlled release; poly(N-vinylcaprolactam)-g-collagen