title: THE POWER OF POOP: FECAL MICROBIOTA TRANSPLANTATION FORCLOSTRIDIUM DIFFICILEINFECTION.
abstract: The human gut is colonized with 200 to 1,000 bacterial species. Administration of antibiotics reduces the diversity of the intestinal microbiota, reduces colonization resistance, and can lead to infection withClostridium difficile. These infections have become more prevalent and increasingly patients are experiencing multiple recurrences that are incurable with standard treatment. Although fecal microbiota transplantation (FMT) has been used for centuries in human and veterinary medicine, only recently has it be shown to be highly effective for recurrentC. difficileinfection. The goal of FMT is to re-introduce a complete, stable community of gut microorganisms to repair or replace the disrupted native microbiota. FMT can be delivered via nasoenteric tube, colonoscopy, or enema. Despite a cure rate approximating 90%, many barriers to FMT have limited its availability to patients. The recent development of a not-for-profit stool bank has helped to make this therapy more accessible. Additional indications for FMT are currently under investigation.
authors.affiliation: IOWA CITY, IOWA.
authors.forename: Michael B
authors.initials: MB
authors.lastname: Edmond
mesh_terms: D016360:Clostridioides difficile; D003015:Clostridium Infections / Q000628:therapy*; D000069467:Fecal Microbiota Transplantation; D005243:Feces / Q000382:microbiology; D006801:Humans