title: Selection of Biopsy Site for Patients with Systematic Amyloidosis.
abstract: Objective To evaluate the sensitivities of various biopsy methods for the diagnosis of systematic amyloidosis (SA). Methods The clinical data and biopsy results of 194 SA patients who were treated in Peking Union Medical College Hospital from January 2009 to June 2015 were retrospectively analyzed. Results The highest sensitivity was achieved by biopsy of affected organs,with renal biopsy 97.4%,heart biopsy 95.0% and liver biopsy 87.5%. Among non-invasive biopsy methods,tongue biopsy was found to be 75% sensitive,followed by gingiva biopsy at 57%,abdominal fat pad aspiration at 57%,rectum biopsy at 16%,and bone marrow examination at 8%. Combination of tongue and abdominal fat pad biopsy yielded a detection rate of 93.1%. Conclusions Biopsy of the involved organ has the highest sensitivity. However,combination of multiple non-invasive biopsy methods may has sensitivity comparable to organ biopsy and is safer and more convenient.
authors.affiliation: Department of Hematology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Chun-Lan
authors.initials: CL
authors.lastname: Zhang
authors.affiliation: Department of Hematology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Jun
authors.initials: J
authors.lastname: Feng
authors.affiliation: Department of Hematology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Xin-Xin
authors.initials: XX
authors.lastname: Cao
authors.affiliation: Department of Hematology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Cong-Li
authors.initials: CL
authors.lastname: Zhang
authors.affiliation: Department of Hematology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Kai-Ni
authors.initials: KN
authors.lastname: Shen
authors.affiliation: Department of Hematology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Xu-Fei
authors.initials: XF
authors.lastname: Huang
authors.affiliation: Department of Hematology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Lu
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Hematology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Dao-Bin
authors.initials: DB
authors.lastname: Zhou
authors.affiliation: Department of Hematology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Jian
authors.initials: J
authors.lastname: Li
mesh_terms: D000273:Adipose Tissue / Q000473:pathology; D000686:Amyloidosis / Q000175:diagnosis*; D001706:Biopsy / Q000379:methods*; D001707:Biopsy, Needle; D006801:Humans; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014059:Tongue / Q000473:pathology