title: Recent advances on smart TiO2nanotube platforms for sustainable drug delivery applications.
abstract: To address the limitations of traditional drug delivery, TiO2nanotubes (TNTs) are recognized as a promising material for localized drug delivery systems. With regard to the excellent biocompatibility and physicochemical properties, TNTs prepared by a facile electrochemical anodizing process have been used to fabricate new drug-releasing implants for localized drug delivery. This review discusses the development of TNTs applied in localized drug delivery systems, focusing on several approaches to control drug release, including the regulation of the dimensions of TNTs, modification of internal chemical characteristics, adjusting pore openings by biopolymer coatings, and employing polymeric micelles as drug nanocarriers. Furthermore, rational strategies on external conditions-triggered stimuli-responsive drug release for localized drug delivery systems are highlighted. Finally, the review concludes with the recent advances on TNTs for controlled drug delivery and corresponding prospects in the future.
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou; National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou.
authors.forename: Qun
authors.initials: Q
authors.lastname: Wang
authors.affiliation: National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou.
authors.forename: Jian-Ying
authors.initials: JY
authors.lastname: Huang
authors.affiliation: Institute of Biomaterials and Engineering, Wenzhou Medical University; Wenzhou Institute of Biomaterials and Engineering, Chinese Academy of Sciences, Wenzhou.
authors.forename: Hua-Qiong
authors.initials: HQ
authors.lastname: Li
authors.affiliation: Wenzhou Institute of Biomaterials and Engineering, Chinese Academy of Sciences, Wenzhou.
authors.forename: Allan Zi-Jian
authors.initials: AZ
authors.lastname: Zhao
authors.affiliation: Wenzhou Institute of Biomaterials and Engineering, Chinese Academy of Sciences, Wenzhou.
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.affiliation: National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou; Research Center of Cooperative Innovation for Functional Organic/Polymer Material Micro/Nanofabrication, Suzhou, People's Republic of China.
authors.forename: Ke-Qin
authors.initials: KQ
authors.lastname: Zhang
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou.
authors.forename: Hong-Tao
authors.initials: HT
authors.lastname: Sun
authors.affiliation: National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou; Research Center of Cooperative Innovation for Functional Organic/Polymer Material Micro/Nanofabrication, Suzhou, People's Republic of China.
authors.forename: Yue-Kun
authors.initials: YK
authors.lastname: Lai
mesh_terms: D000818:Animals; D020099:Coated Materials, Biocompatible; D016503:Drug Delivery Systems; D004343:Drug Implants; D004563:Electrochemistry; D004566:Electrodes; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008280:Magnetics; D008823:Micelles; D043942:Nanotubes / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy*; D011108:Polymers / Q000737:chemistry; D014025:Titanium / Q000737:chemistry*; D014465:Ultrasonics
chemical_list: D020099:Coated Materials, Biocompatible; D004343:Drug Implants; D008823:Micelles; D011108:Polymers; C009495:titanium dioxide; D014025:Titanium
keywords: TiO2 nanotubes; drug-releasing implant; electrochemical anodization; modification; stimulated drug delivery