title: A Simple Mathematical Model for Wound Closure Evaluation.
abstract: The incidence of ulcers associated to type 2 diabetes mellitus (T2DM) increases every year. We introduce and explore a new mathematical algorithm to evaluate wound-healing in foot ulcers associated to T2DM. Fifteen patients (nine women and six men), mean age of 70 ± 16 years were included. The evolution of their wounds followed-up for a period of 18-45 days. According to the Wagner grading system the ulcers were grade I (5 patients), grade II (9 patients), and grade III (1 patient). Clinically, the type of the ulcers was neuroischemic (12 patients) and neuropathic (3 patients). A new parameter is introduced, the "continuous linear healing rate" Dc that was more accurate with higher values and requires less quantifications than usual formulas to make a wound-healing projection.
authors.affiliation: Instituto de Anatomía, Histología y Patología, Facultad de Medicina, Universidad Austral de Chile, Valdivia, Chile.
authors.forename: Alejandra
authors.initials: A
authors.lastname: Vidal
authors.affiliation: Facultad de Medicina, Universidad Autónoma del Estado de México, Toluca, Estado de México, Mexico.
authors.forename: Hugo
authors.initials: H
authors.lastname: Mendieta Zerón
authors.affiliation: Instituto de Anatomía, Histología y Patología, Facultad de Medicina, Universidad Austral de Chile, Valdivia, Chile.
authors.forename: Israel
authors.initials: I
authors.lastname: Giacaman
authors.affiliation: Centro de Investigación en Ciencias Médicas (CICMED), Universidad Autónoma del Estado de México, Toluca, Estado de México, Mexico.
authors.forename: María Del Socorro
authors.initials: MD
authors.lastname: Camarillo Romero
authors.affiliation: Facultad de Medicina, Universidad Autónoma del Estado de México, Toluca, Estado de México, Mexico.
authors.forename: Sandra Parra
authors.initials: SP
authors.lastname: López
authors.affiliation: Facultad de Ciencias de la Salud, Universidad de Anáhuac, Huixquilucan, Estado de México, Mexico.
authors.forename: Laura E
authors.initials: LE
authors.lastname: Meza Trillo
authors.affiliation: Universidad del Valle de Toluca, Toluca, Estado de México, Mexico.
authors.forename: David A
authors.initials: DA
authors.lastname: Pérez Pérez
authors.affiliation: Instituto de Anatomía, Histología y Patología, Facultad de Medicina, Universidad Austral de Chile, Valdivia, Chile.
authors.forename: Miguel
authors.initials: M
authors.lastname: Concha
authors.affiliation: Instituto de Ciencias Químicas, Facultad de Ciencias, Universidad Austral de Chile, Valdivia, Chile.
authors.forename: César
authors.initials: C
authors.lastname: Torres-Gallegos
authors.affiliation: Instituto de Ciencias Químicas, Facultad de Ciencias, Universidad Austral de Chile, Valdivia, Chile.
authors.forename: Sandra L
authors.initials: SL
authors.lastname: Orellana
authors.affiliation: Departamento de Ciencias & Tecnologías Farmacéuticas, Universidad de Chile, Santiago, Chile.
authors.forename: Felipe
authors.initials: F
authors.lastname: Oyarzun-Ampuero
authors.affiliation: Departamento de Ciencias & Tecnologías Farmacéuticas, Universidad de Chile, Santiago, Chile.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Moreno-Villoslada
keywords: Diabetic foot; Foot ulcers; Mathematical model; Wounds