title: Eyelid and feet edema induced by pemetrexed.
abstract: Pemetrexed is an anti-metabolite that targets multiple enzymes in folate pathway. The main toxicities associated with pemetrexed are asthenia, nausea, diarrhea, myelosuppression, and rash. Few cases of pemetrexed induced cutaneous adverse event have been reported, mainly periorbital-facial edema and edema of the limbs. We report a case of pemetrexed-induced edema of the eyelid and feet in a patient with adenocarcinoma of the lung.
authors.affiliation: National Center of Pharmacovigilance, Tunis, Tunisia; Department of Pharmacology, Faculty of Medicine, Tunis El Manar University, Tunis, Tunisia.
authors.forename: Sarrah
authors.initials: S
authors.lastname: Kastalli
authors.affiliation: National Center of Pharmacovigilance, Tunis, Tunisia; Department of Pharmacology, Faculty of Medicine, Tunis El Manar University, Tunis, Tunisia.
authors.forename: Ons
authors.initials: O
authors.lastname: Charfi
authors.affiliation: National Center of Pharmacovigilance, Tunis, Tunisia; Department of Pharmacology, Faculty of Medicine, Tunis El Manar University, Tunis, Tunisia.
authors.forename: Rym
authors.initials: R
authors.lastname: Sahnoun
authors.affiliation: National Center of Pharmacovigilance, Tunis, Tunisia; Department of Pharmacology, Faculty of Medicine, Tunis El Manar University, Tunis, Tunisia.
authors.forename: Ghozlane
authors.initials: G
authors.lastname: Lakhoua
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D004487:Edema / Q000139:chemically induced* / Q000175:diagnosis*; D005143:Eyelids / Q000473:pathology*; D005260:Female; D005528:Foot / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D000068437:Pemetrexed / Q000009:adverse effects*
chemical_list: D000970:Antineoplastic Agents; D000068437:Pemetrexed
keywords: Pemetrexed; pharmacovigilance; side effects