title: Applying Naive Bayesian Networks to Disease Prediction: a Systematic Review.
abstract: BACKGROUND
  Naive Bayesian networks (NBNs) are one of the most effective and simplest Bayesian networks for prediction.
  
  
  OBJECTIVE
  This paper aims to review published evidence about the application of NBNs in predicting disease and it tries to show NBNs as the fundamental algorithm for the best performance in comparison with other algorithms.
  
  
  METHODS
  PubMed was electronically checked for articles published between 2005 and 2015. For characterizing eligible articles, a comprehensive electronic searching method was conducted. Inclusion criteria were determined based on NBN and its effects on disease prediction. A total of 99 articles were found. After excluding the duplicates (n= 5), the titles and abstracts of 94 articles were skimmed according to the inclusion criteria. Finally, 38 articles remained. They were reviewed in full text and 15 articles were excluded. Eventually, 23 articles were selected which met our eligibility criteria and were included in this study.
  
  
  RESULTS
  In this article, the use of NBN in predicting diseases was described. Finally, the results were reported in terms of Accuracy, Sensitivity, Specificity and Area under ROC curve (AUC). The last column in Table 2 shows the differences between NBNs and other algorithms.
  
  
  CONCLUSIONS
  This systematic review (23 studies, 53,725 patients) indicates that predicting diseases based on a NBN had the best performance in most diseases in comparison with the other algorithms. Finally in most cases NBN works better than other algorithms based on the reported accuracy.
  
  
  CONCLUSIONS
  The method, termed NBNs is proposed and can efficiently construct a prediction model for disease.
authors.affiliation: Department of Health Information Management, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Mostafa
authors.initials: M
authors.lastname: Langarizadeh
authors.affiliation: Department of Health Information Management, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Fateme
authors.initials: F
authors.lastname: Moghbeli
keywords: Naive Bayes Algorithms; Naive Bayes Models; Naive Bayesian Network; Naive Bayesian Network and disease prediction