title: Lactobacillus plantarumfavors the early emergence of fit and fertile adultDrosophilaupon chronic undernutrition.
abstract: Animals are naturally surrounded by a variety of microorganisms with which they constantly interact. Among these microbes, some live in close association with a host and form its microbiota. These communities are being extensively studied, owing to their contributions to shaping various aspects of animal physiology. One of these commensal species,Lactobacillus plantarum, and in particular theL.p.WJLstrain, has been shown to promote the growth ofDrosophilalarvae upon nutrient scarcity, allowing earlier metamorphosis and adult emergence compared with axenic individuals. As for many insects, conditions surrounding the post-embryonic development dictate key adult life history traits inDrosophila, and adjusting developmental timing according to the environment is essential for adult fitness. Thus, we wondered whether the growth acceleration induced byL.p.WJLin a context of poor nutrition could adversely impact the fitness ofDrosophilaadults. Here, we show that theL.p.WJL-mediated acceleration of growth is not deleterious; adults emerging after an accelerated development are as fit as their axenic siblings. Additionally, the presence ofL.p.WJLeven leads to a lifespan extension in nutritionally challenged males. These results demonstrate thatL.p.WJLis a beneficial partner forDrosophila melanogasterthrough its entire life cycle. Thus, commensal bacteria allow the earlier emergence and longer survival of fit and fertile individuals and might represent one of the factors contributing to the ecological success ofDrosophila.
authors.affiliation: Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Ecole Normale Supérieure de Lyon, Centre National de la Recherche Scientifique, Université Claude Bernard Lyon 1, Unité Mixte de Recherche 5242, Lyon, Cedex 07 69364, France.
authors.forename: Mélisandre A
authors.initials: MA
authors.lastname: Téfit
authors.affiliation: Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Ecole Normale Supérieure de Lyon, Centre National de la Recherche Scientifique, Université Claude Bernard Lyon 1, Unité Mixte de Recherche 5242, Lyon, Cedex 07 69364, France francois.leulier@ens-lyon.fr.
authors.forename: François
authors.identifier: 0000-0002-4542-3053
authors.initials: F
authors.lastname: Leulier
mesh_terms: D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D004330:Drosophila / Q000254:growth & development* / Q000382:microbiology* / Q000502:physiology; D005260:Female; D005298:Fertility; D005508:Food Deprivation; D048191:Lactiplantibacillus plantarum / Q000502:physiology*; D008136:Longevity; D008297:Male; D013559:Symbiosis
keywords: Fertility; Fitness; Lifespan; Microbiota; Symbiosis