title: Comparative Analysis of the Antineoplastic Activity of C60Fullerene with 5-Fluorouracil and Pyrrole Derivative In Vivo.
abstract: The antitumor activity of pristine C60fullerene aqueous solution (C60FAS) compared to 5-fluorouracil (5-FU) and pyrrole derivative 1-(4-Cl-benzyl)-3-Cl-4-(CF3-fenylamino)-1H-pyrrol-2.5-dione (MI-1) cytostatic drugs was investigated and analyzed in detail using the model of colorectal cancer induced by 1.2-dimethylhydrazine (DMH) in rats. The number, size, and location of the tumors were measured, and the pathology was examined. It was found that the number of tumors and total lesion area decreased significantly under the action of C60FAS and MI-1. Because these drugs have different mechanisms of action, their simultaneous administration can potentially increase the effectiveness and significantly reduce the side effects of antitumor therapy.
authors.affiliation: Taras Shevchenko National University of Kyiv, 64 Volodymyrska Str, 01601, Kyiv, Ukraine. o.lynchak@gmail.com.
authors.forename: O V
authors.initials: OV
authors.lastname: Lynchak
authors.affiliation: Taras Shevchenko National University of Kyiv, 64 Volodymyrska Str, 01601, Kyiv, Ukraine.
authors.forename: Yu I
authors.initials: YI
authors.lastname: Prylutskyy
authors.affiliation: Taras Shevchenko National University of Kyiv, 64 Volodymyrska Str, 01601, Kyiv, Ukraine.
authors.forename: V K
authors.initials: VK
authors.lastname: Rybalchenko
authors.affiliation: Taras Shevchenko National University of Kyiv, 64 Volodymyrska Str, 01601, Kyiv, Ukraine.|Joint Institute for Nuclear Research, Dubna, Moscow Region, Russia.
authors.forename: O A
authors.initials: OA
authors.lastname: Kyzyma
authors.affiliation: Joint Institute for Nuclear Research, Dubna, Moscow Region, Russia.|Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region, Russia.
authors.forename: D
authors.initials: D
authors.lastname: Soloviov
authors.affiliation: Sevastopol State University, Sevastopol, Crimea, Ukraine.
authors.forename: V V
authors.initials: VV
authors.lastname: Kostjukov
authors.affiliation: Sevastopol State University, Sevastopol, Crimea, Ukraine.|Belgorod State University, 85 Pobedy Str, 308015, Belgorod, Russia.
authors.forename: M P
authors.initials: MP
authors.lastname: Evstigneev
authors.affiliation: Institute of Chemistry and Biotechnology, Technical University of Ilmenau, 25 Weimarer Str, 98693, Ilmenau, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Ritter
authors.affiliation: Institute of Chemistry and Biotechnology, Technical University of Ilmenau, 25 Weimarer Str, 98693, Ilmenau, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Scharff
keywords: 5-Fluorouracil; C60 fullerene; Colorectal cancer; Molecular modeling; Pyrrole derivative; Small-angle X-ray scattering