title: HIV and Nonischemic Heart Disease.
abstract: Human immunodeficiency virus (HIV)-associated heart disease encompasses a broad spectrum of diseases. HIV infection may involve the pericardium, myocardium, coronary arteries, pulmonary vasculature, and valves, as well as the systemic vasculature. Access to combination antiretroviral therapy, as well as health resources, has had a significant influence on the prevalence and severity of the effects on each cardiac structure. Investigations over the recent past have improved our understanding of the epidemiology and pathophysiology of HIV-associated cardiovascular disease. This review will focus on our current understanding of pathogenesis and risk factors associated with HIV infection and heart disease, and it will discuss relevant advances in diagnosis and management of these conditions.
authors.affiliation: Division of Cardiology, Department of Medicine, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa. Electronic address: Pravin.Manga@wits.ac.za.
authors.forename: Pravin
authors.initials: P
authors.lastname: Manga
authors.affiliation: Division of Cardiology, Department of Medicine, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa.
authors.forename: Keir
authors.initials: K
authors.lastname: McCutcheon
authors.affiliation: Division of Cardiology, Department of Medicine, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa.
authors.forename: Nqoba
authors.initials: N
authors.lastname: Tsabedze
authors.affiliation: Division of Cardiology, Department of Medicine, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Vachiat
authors.affiliation: Division of Cardiology, Department of Medicine, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa.
authors.forename: Don
authors.initials: D
authors.lastname: Zachariah
mesh_terms: D014943:Global Health; D006678:HIV; D015658:HIV Infections / Q000150:complications* / Q000453:epidemiology; D006331:Heart Diseases / Q000453:epidemiology* / Q000209:etiology; D006801:Humans; D015995:Prevalence; D012307:Risk Factors
keywords: HIV-associated cardiomyopathy; HIV-associated pulmonary artery hypertension; acquired immunodeficiency syndrome; antiretroviral agents