title: The Effectiveness of Intraocular Methotrexate in the Treatment of Posterior Uveitis in Behçet's Disease Patients Compared to Retrobulbar Steroids Injection.
abstract: Aim of Work. To evaluate the efficacy of intravitreal methotrexate (MTX) compared to retrobulbar triamcinolone acetonide (TAA), in controlling posterior segment involvement and inducing remissions among Behçet's disease (BD) patients.Study Design. This is a cross-sectional nonrandomized comparative study.Patients and Methods. 31 adult BD male patients with a mean disease duration of 5.45 years who presented with bilateral posterior segment involvement were included. Each patient received intravitreal injection of 400μg/0.1 mL (MTX) for the right eye (Group A) and 1 mL of retrobulbar 40 mg/mL TAA for the left eye (Group B).Results. 90% of eyes showed complete improvement of anterior chamber reaction, whereas an improvement in vitreous activity in 77% with no significant differences between both groups (p≤ 0.1). BCVA improved in 77.4% eyes (Group A) compared to 87.1% (Group B) (p≤ 0.4). Relapses were noted in 11 eyes (35.5%), in group A, with the mean duration of remission being 19.1 weeks ± 2.13 compared to 7.35 ± 2.8 in 20 eyes (64.5%) in group B (p≤ 0.1).Conclusion. No statistical differences were found between both treatment modalities; however, based on clinical observations, intravitreal MTX may ensure better control of inflammatory reaction and may encourage longer remission as compared to retrobulbar TAA in BD patients.
authors.affiliation: Beni Suef University, Beni Suef, Egypt.
authors.forename: Hossam El Din Mohamed
authors.initials: HE
authors.lastname: Khalil
authors.affiliation: Cairo University, Giza, Egypt.
authors.forename: Heba A
authors.identifier: 0000-0003-2647-5883
authors.initials: HA
authors.lastname: El Gendy
authors.affiliation: Cairo University, Giza, Egypt.
authors.forename: Hala Ahmed Raafat
authors.initials: HA
authors.lastname: Youssef
authors.affiliation: Beni Suef University, Beni Suef, Egypt.
authors.forename: Hazem Effat
authors.initials: HE
authors.lastname: Haroun
authors.affiliation: Cairo University, Giza, Egypt.
authors.forename: Tamer Atef
authors.initials: TA
authors.lastname: Gheita
authors.affiliation: Beni Suef University, Beni Suef, Egypt.
authors.forename: Hossam Mahmoud
authors.initials: HM
authors.lastname: Bakir