title: The effect of premorbid intelligence on neurocognitive and psychosocial functioning in bipolar disorder.
abstract: The aim of this study was to assess if premorbid IQ moderates the association between measures of clinical severity and neurocognitive or psychosocial functioning in euthymic patients with bipolar disorder.
  
  
  
  One hundred and nineteen outpatients and forty healthy controls were included. The length of illness, number of previous hypo/manic and depressive episodes, episode density, and history of psychosis assessed clinical severity. Performances in verbal memory, attention, and executive functions, as well as level of psychosocial functioning were used as outcomes.
  
  
  
  The negative relationship between number of hypo/manic episodes and performance in executive functions decreased as a function of higher values of premorbid IQ. No other influences of premorbid IQ were found in the association between clinical severity measures and neurocognitive and psychosocial functioning.
  
  
  
  Premorbid IQ might moderate the relationship between the number of hypo/manic episodes and executive functioning in bipolar disorder. Possible interpretations of this finding are discussed.
authors.affiliation: Bipolar Disorder Program, Institute of Neurosciences, Favaloro University, Buenos Aires, Argentina; National Council of Scientific and Technical Research (CONICET), Argentina; Institute of Cognitive and Translational Neuroscience (INCyT), INECO Foundation, Favaloro University, Buenos Aires, Argentina. Electronic address: diejmartino@gmail.com.
authors.forename: Diego J
authors.initials: DJ
authors.lastname: Martino
authors.affiliation: National Council of Scientific and Technical Research (CONICET), Argentina; Psychiatric Emergencies Hospital Torcuato de Alvear, Buenos Aires, Argentina.
authors.forename: Marina P
authors.initials: MP
authors.lastname: Valerio
authors.affiliation: Bipolar Disorder Program, Institute of Neurosciences, Favaloro University, Buenos Aires, Argentina; Psychiatric Emergencies Hospital Torcuato de Alvear, Buenos Aires, Argentina.
authors.forename: Alejandro G
authors.initials: AG
authors.lastname: Szmulewicz
authors.affiliation: Bipolar Disorder Program, Institute of Neurosciences, Favaloro University, Buenos Aires, Argentina; Institute of Cognitive and Translational Neuroscience (INCyT), INECO Foundation, Favaloro University, Buenos Aires, Argentina.
authors.forename: Sergio A
authors.initials: SA
authors.lastname: Strejilevich
mesh_terms: D000328:Adult; D001288:Attention / Q000502:physiology; D001714:Bipolar Disorder / Q000523:psychology*; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000503:physiopathology*; D003866:Depressive Disorder / Q000523:psychology; D056344:Executive Function / Q000502:physiology*; D005260:Female; D006801:Humans; D007360:Intelligence / Q000502:physiology*; D008297:Male; D008568:Memory / Q000502:physiology; D008875:Middle Aged; D009483:Neuropsychological Tests; D012044:Regression Analysis; D055815:Young Adult
keywords: Cognitive reserve; Executive functions; Premorbid IQ