title: Stereodivergent Coupling of Aldehydes and Alkynes via Synergistic Catalysis Using Rh and Jacobsen's Amine.
abstract: We report an enantioselective coupling between α-branched aldehydes and alkynes to generate vicinal quaternary and tertiary carbon stereocenters. The choice of Rh and organocatalyst combination allows for access to all possible stereoisomers with high enantio-, diastereo-, and regioselectivity. Our study highlights the power of catalysis to activate two common functional groups and provide access to divergent stereoisomers and constitutional structures.
authors.affiliation: Department of Chemistry, University of California , Irvine, California 92697, United States.
authors.forename: Faben A
authors.initials: FA
authors.lastname: Cruz
authors.affiliation: Department of Chemistry, University of California , Irvine, California 92697, United States.
authors.forename: Vy M
authors.identifier: 0000-0002-8099-1048
authors.initials: VM
authors.lastname: Dong
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000480:Alkynes / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D000480:Alkynes; D000588:Amines; D012238:Rhodium