title: A new pyridine alkaloid from Zingiberis rhizoma.
abstract: A new alkaloid, named 2-methoxy-4-(2-(2-pyridine)-ethyl) phenol (1), together with two known compounds, was isolated from Zingiberis rhizoma. Their structures were elucidated on the basis of 1D and 2D NMR spectra and MS spectra. Compound 1 exhibited substantial bioactivity against Canidia albicans ATCC 10231 with a minimum inhibitory concentration of 1.0 mg/mL.
authors.affiliation: a Laboratory of Modern Preparation of TCM, Ministry of Education , Jiangxi University of Traditional Chinese Medicine , Nanchang , China.
authors.forename: Feng
authors.initials: F
authors.lastname: Shao
authors.affiliation: a Laboratory of Modern Preparation of TCM, Ministry of Education , Jiangxi University of Traditional Chinese Medicine , Nanchang , China.
authors.forename: Ding-Qing
authors.initials: DQ
authors.lastname: Wang
authors.affiliation: b College of Pharmacy , Jiangxi University of Traditional Chinese Medicine , Nanchang , China.
authors.forename: Wei
authors.initials: W
authors.lastname: Xiong
authors.affiliation: a Laboratory of Modern Preparation of TCM, Ministry of Education , Jiangxi University of Traditional Chinese Medicine , Nanchang , China.
authors.forename: Pu-Zhao
authors.initials: PZ
authors.lastname: Zhang
authors.affiliation: c College of Life Science , Jiangxi University of Traditional Chinese Medicine , Nanchang , China.
authors.forename: Guang-Qiang
authors.initials: GQ
authors.lastname: Ma
authors.affiliation: a Laboratory of Modern Preparation of TCM, Ministry of Education , Jiangxi University of Traditional Chinese Medicine , Nanchang , China.
authors.forename: Rong-Hua
authors.initials: RH
authors.lastname: Liu
authors.affiliation: b College of Pharmacy , Jiangxi University of Traditional Chinese Medicine , Nanchang , China.
authors.forename: Xue-Lian
authors.initials: XL
authors.lastname: Yao
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010636:Phenols / Q000032:analysis; D010936:Plant Extracts / Q000737:chemistry; D011725:Pyridines; D027343:Rhizome / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D000935:Antifungal Agents; D010636:Phenols; D010936:Plant Extracts; D011725:Pyridines; C023666:pyridine
keywords: 2-Methoxy-4-(2-(2-pyridine)-ethyl) phenol; Cyclo-(4-methyl-R-Pro-S-Nva); Zingiberis rhizoma; antibacterial activity; antifungal activity; zingerone