title: Human leukocyte antigen HLADRB1 determinants susceptibility to gastroesophageal reflux disease.
abstract: BACKGROUND
  - Gastroesophageal reflux disease (GERD) is characterized by diverse symptoms. There is an evidence for a genetic component to GERD as supported by familial aggregation of this disease.
  
  
  OBJECTIVE
  - To investigate whether certain human leucocyte antigen genes HLA-DRB1 are associated with GERD.
  
  
  METHODS
  - Patients and controls were prospectively recruited from GIT center at Al-Kindy Teaching Hospital (Baghdad-Iraq) between January 2014 and July 2016. Sixty Iraqi Arab Muslims patients with a history of heartburn and dyspepsia compared with 100 Iraqi Arab Muslims controls. All study patients and control groups underwent upper gastrointestinal endoscopic examinations and their serums were analyzed for CagA antibodies Immunoglobulin G (IgG) for H. pylori. HLA-DRB1 genotyping were done to both groups.
  
  
  RESULTS
  - A total of 60 patients with erosive gastritis; GERD (Grade II and III) were evaluated, together with 100 controls. There is a significant increase of H. pylori infection (P=0.0001) in GERD patients than control group. HLA-DRB1* 15:01 was significantly increased in GERD patients in comparison with control group and an increased frequency of HLADRB1*11:01 in control group compared with patients group.
  
  
  CONCLUSIONS
  - There is an association between HLA-DRB1 *15:01 in GERD patients with H. pylori positive patients.
authors.affiliation: Department of Microbiology, Al-Kindy College of Medicine, Baghdad University, Iraq.
authors.forename: Batool Mutar
authors.initials: BM
authors.lastname: Mahdi
authors.affiliation: Department of Surgery, Al-Kindy College of Medicine, University of Baghdad, Iraq.
authors.forename: Riyadh Mohamad
authors.initials: RM
authors.lastname: Hasan
authors.affiliation: Department of Microbiology, Al-Kindy College of Medicine, Baghdad University, Iraq.
authors.forename: Wafaa Hazim
authors.initials: WH
authors.lastname: Salih
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D005764:Gastroesophageal Reflux / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D059811:HLA-DRB1 Chains / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012720:Severity of Illness Index
chemical_list: D059811:HLA-DRB1 Chains