title: Earlier and broader roles of Mesp1 in cardiovascular development.
abstract: Mesoderm posterior 1 is one of earliest markers of the nascent mesoderm. Its best-known function is driving the onset of the cardiovascular system. In the past decade, new evidence supports that Mesp1 acts earlier with greater breadth in cell fate decisions, and through cell-autonomous and cell non-autonomous mechanisms. This review summarizes these new aspects, with an emphasis on the upstream and downstream regulation around Mesp1 and how they may guide cell fate reprogramming.
authors.affiliation: Department of Biology and Biochemistry, University of Houston, Houston, TX, 77204, USA. yliu54@uh.edu.
authors.forename: Yu
authors.identifier: 0000-0002-1282-4897
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000378:metabolism*; D002319:Cardiovascular System / Q000196:embryology* / Q000378:metabolism*; D065150:Cellular Reprogramming; D002999:Clone Cells; D006801:Humans; D008648:Mesoderm / Q000378:metabolism; D032383:Myocytes, Cardiac / Q000166:cytology / Q000378:metabolism
chemical_list: D051792:Basic Helix-Loop-Helix Proteins
keywords: Cardiomyocyte; Cell fate; Mesoderm; Reprogramming; Stem cell