title: Neural stem cells in lead toxicity.
abstract: Lead (Pb) exposure in the early stages of neurodevelopment results in long-lasting alterations that ultimately cognitive function and behaviour. The prime targets of lead toxicity are the multipotent neural stem cells (NSCs). The present review will discuss the basic molecular physiology involved in the toxicity mechanisms induced by lead and its resultant counter effects on nervous system and physiology. The article shall help researchers working in the area to design new drugs and therapeutics for the efficient management of neuro-toxic states especially upon prenatal exposure to lead.
authors.affiliation: Department of Neurology, Xuzhou Central Hospital, Xuzhou, Jiangsu, China. 85252095@Qq.com.
authors.forename: W-W
authors.initials: WW
authors.lastname: Chen
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.forename: W-J
authors.initials: WJ
authors.lastname: Huang
mesh_terms: D003071:Cognition / Q000187:drug effects*; D006801:Humans; D007854:Lead / Q000633:toxicity*; D058953:Neural Stem Cells / Q000187:drug effects* / Q000502:physiology; D013234:Stem Cells
chemical_list: D007854:Lead