title: Association between Zika virus and fetopathy: a prospective cohort study in French Guiana.
abstract: OBJECTIVE
  To establish the incidence of fetal central nervous system (CNS) anomalies (including microcephaly), signs of congenital infection and fetal loss in pregnant women infected with Zika virus (ZIKV) and non-infected pregnant women in western French Guiana.
  
  
  METHODS
  This prospective cohort study was conducted between 1 January and 15 July 2016. We evaluated and compared clinical and fetal ultrasound examinations of 301 pregnant women with biological confirmation of ZIKV infection and 399 pregnant women who were negative for ZIKV infection.
  
  
  RESULTS
  Overall, the total number of fetuses with CNS involvement was higher in the infected than in the control group (9.0% vs 4.3%; relative risk, 2.11 (95% CI, 1.18-4.13)). Anomalies of the corpus callosum and presence of cerebral hyperechogenicities were significantly more common in the infected group. There was an increased risk of microcephaly in the infected compared with the control group (1.7% vs 0.3%; relative risk, 6.63 (95% CI, 0.78-57.83)), although this was not statistically significant. When the mother was infected during the first or second trimester, there was a greater risk of severe CNS involvement, more signs of infection and intrauterine fetal death than with infection in the third trimester. The rate of vertical transmission in the exposed group was 10.9%.
  
  
  CONCLUSIONS
  ZIKV infection during pregnancy is associated with a significant risk of fetal CNS involvement and intrauterine fetal death, particularly when infection occurs during the first or second trimesters. Microcephaly was not present in every case of congenital ZIKV syndrome that we observed. Until more is known about this disease, it is paramount to evaluate suspected cases by detailed neurosonography on a monthly basis, paying particular attention to the corpus callosum and the presence of hyperechogenic foci. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd.
authors.affiliation: Department of Obstetrics and Gynecology, St-Laurent du Maroni's Hospital, Centre Hospitalier de l'Ouest Guyanais, Saint-Laurent du Maroni, French Guiana.
authors.forename: L
authors.identifier: http://orcid.org/0000-0002-3021-8129
authors.initials: L
authors.lastname: Pomar
authors.affiliation: Division of Ultrasound in Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: G
authors.initials: G
authors.lastname: Malinger
authors.affiliation: Service de Gynécologie-Obstétrique et Médecine de la Reproduction, CHU de Caen, Université de Caen, Caen, Normandy, France.
authors.forename: G
authors.initials: G
authors.lastname: Benoist
authors.affiliation: Department of Obstetrics and Gynecology, St-Laurent du Maroni's Hospital, Centre Hospitalier de l'Ouest Guyanais, Saint-Laurent du Maroni, French Guiana.
authors.forename: G
authors.initials: G
authors.lastname: Carles
authors.affiliation: Department of Obstetrics and Fetal Medicine, Université Paris Descartes, Hospital Necker-Enfants Malades, Paris, France.
authors.forename: Y
authors.initials: Y
authors.lastname: Ville
authors.affiliation: Institut Pasteur of French Guiana, Laboratory of Virology, National Referral Center for Arboviruses, Cayenne, French Guiana.
authors.forename: D
authors.initials: D
authors.lastname: Rousset
authors.affiliation: Department of Obstetrics and Gynecology, St-Laurent du Maroni's Hospital, Centre Hospitalier de l'Ouest Guyanais, Saint-Laurent du Maroni, French Guiana.
authors.forename: N
authors.initials: N
authors.lastname: Hcini
authors.affiliation: Department of Obstetrics and Gynecology, St-Laurent du Maroni's Hospital, Centre Hospitalier de l'Ouest Guyanais, Saint-Laurent du Maroni, French Guiana.
authors.forename: C
authors.initials: C
authors.lastname: Pomar
authors.affiliation: Sorbonne Universités, UPMC Universités Paris 06, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Department of Social Epidemiology, Paris, France.|Public Health Department, St-Laurent du Maroni's Hospital, Centre Hospitalier de l'Ouest Guyanais, Saint-Laurent du Maroni, French Guiana.
authors.forename: A
authors.initials: A
authors.lastname: Jolivet
authors.affiliation: Department of Obstetrics and Gynecology, St-Laurent du Maroni's Hospital, Centre Hospitalier de l'Ouest Guyanais, Saint-Laurent du Maroni, French Guiana.
authors.forename: V
authors.initials: V
authors.lastname: Lambert
mesh_terms: D000293:Adolescent; D000328:Adult; D015331:Cohort Studies; D004196:Disease Outbreaks; D005260:Female; D005616:French Guiana / Q000453:epidemiology; D006801:Humans; D008831:Microcephaly / Q000517:prevention & control* / Q000821:virology; D008875:Middle Aged; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology* / Q000517:prevention & control; D011446:Prospective Studies; D055815:Young Adult; D000071244:Zika Virus / Q000472:pathogenicity*; D000071243:Zika Virus Infection / Q000453:epidemiology* / Q000517:prevention & control
keywords: Zika virus; congenital Zika virus syndrome; congenital infection; microcephaly; ultrasound