title: Role of metalloproteinases MMP-2 in asthma.
abstract: Background - Many metalloproteinases (MMPs) play a role in the pathogenesis and modulation of the severity of asthma. MMP-9 is the predominant in asthma but other MMPs are involved such as the MMP-2. Aim - To determine the role of single nucleotide polymorphism of the gene MMP2 in susceptibility to asthma and its severity. Methods - Study case-control with prospectively enrolled patients with asthma and healthy subjects. We determined within two groups genotypes corresponding to the MMP2 polymorphism in -735C / T position, using a polymerase chain amplification technique associated with a polymorphism in the length of restriction fragments. Results - We included 150 patients with asthma and 150 healthy controls. Comparison of allele and genotype frequencies of the studied polymorphisms between patients and controls showed that there was no association between the SNP-735C / T and susceptibility to asthma and its severity. Conclusion - The role of MMP 2 in asthma remains unclear and no study has been conducted till date, to determine the role of MMP-2 -735C/T gene polymorphism in asthma. This study does not disprove such association. Further studies are needed to clarify the exact role the pathogenesis of asthma.
authors.forename: Sonia
authors.initials: S
authors.lastname: Toujani
authors.forename: Nadia
authors.initials: N
authors.lastname: Mehiri
authors.forename: Kamel
authors.initials: K
authors.lastname: Hamzaoui
authors.forename: Hela
authors.initials: H
authors.lastname: Hadded
authors.forename: Nozha
authors.initials: N
authors.lastname: Ben Salah
authors.forename: Meriem
authors.initials: M
authors.lastname: Mjid
authors.forename: Yacine
authors.initials: Y
authors.lastname: Ouahchi
authors.forename: Bechir
authors.initials: B
authors.lastname: Louzir
authors.forename: Jalloul
authors.initials: J
authors.lastname: Daghfous
authors.forename: Jouda
authors.initials: J
authors.lastname: Cherif
authors.forename: Majed
authors.initials: M
authors.lastname: Beji
mesh_terms: D001249:Asthma / Q000201:enzymology*; D016022:Case-Control Studies; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D020778:Matrix Metalloproteinase 2 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D020778:Matrix Metalloproteinase 2