title: Mitral valve replacement using a handmade construct in an infant.
abstract: We recently reported the feasibility of a handmade left atrioventricular valve using decellularized extracellular matrix for 3 months in a failed repair of AV canal defect. We present the use of an extracellular matrix mitral valve for 9 months in an infant with an un-repairable congenitally malformed valve. The valve functioned perfectly without anticoagulation until the patient expired from non-cardiac complications of their fibrillin gene defect. This report adds further experience using valves made from extracellular matrix in the systemic ventricle both in terms of application and in terms of short-term durability of the construct.
authors.affiliation: Section of Pediatric and Congenital Cardiac Surgery, The Heart Institute, Joe DiMaggio Children's Hospital, Hollywood, Florida.
authors.forename: Steven
authors.initials: S
authors.lastname: Bibevski
authors.affiliation: Department of Radiation Oncology, Gustave Roussy, Université Paris-Saclay, Institut Thoracique d'Oncologie (IOT), Villejuif, France.|INSERM U1030, Molecular Radiotherapy, Gustave Roussy, Université Paris-Saclay, Villejuif, France.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Levy
authors.affiliation: Section of Pediatric and Congenital Cardiac Surgery, The Heart Institute, Joe DiMaggio Children's Hospital, Hollywood, Florida.
authors.forename: Frank G
authors.initials: FG
authors.lastname: Scholl
mesh_terms: D005109:Extracellular Matrix; D005260:Female; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D007223:Infant; D008944:Mitral Valve Insufficiency / Q000601:surgery*; D011474:Prosthesis Design
keywords: Extracellular matrix; Infant; Mitral; Replacement; Valve