title: Synthesis, Characterization and Immunological Evaluation of Self-Adjuvanting Group A Streptococcal Vaccine Candidates Bearing Various Lipidic Adjuvanting Moieties.
abstract: Four group A streptococcal glycolipopeptide vaccine candidates with different lipidic adjuvanting moieties were prepared and characterized. The immunogenicity of the compounds was evaluated by macrophage and dendritic cell uptake studies and by in vivo quantification of systemic IgG antibody by ELISA. Three of the candidates showed significant induction of the IgG response.
authors.affiliation: School of Chemistry and Molecular Biosciences, The University of Queensland, Cooper Road, St. Lucia, QLD, 4072, Australia.
authors.forename: Vincent
authors.initials: V
authors.lastname: Fagan
authors.affiliation: School of Chemistry and Molecular Biosciences, The University of Queensland, Cooper Road, St. Lucia, QLD, 4072, Australia.
authors.forename: Waleed M
authors.initials: WM
authors.lastname: Hussein
authors.affiliation: School of Chemistry and Molecular Biosciences, The University of Queensland, Cooper Road, St. Lucia, QLD, 4072, Australia.
authors.forename: Mei
authors.initials: M
authors.lastname: Su
authors.affiliation: School of Chemistry and Molecular Biosciences, The University of Queensland, Cooper Road, St. Lucia, QLD, 4072, Australia.
authors.forename: Ashwini K
authors.initials: AK
authors.lastname: Giddam
authors.affiliation: Institute for Glycomics, Griffith University, Gold Coast, 4215, Australia.
authors.forename: Michael R
authors.initials: MR
authors.lastname: Batzloff
authors.affiliation: Institute for Glycomics, Griffith University, Gold Coast, 4215, Australia.
authors.forename: Michael F
authors.initials: MF
authors.lastname: Good
authors.affiliation: School of Chemistry and Molecular Biosciences, The University of Queensland, Cooper Road, St. Lucia, QLD, 4072, Australia.|School of Pharmacy, Pharmacy Australia Centre of Excellence, The University of Queensland, Cornwall Street, Woolloongabba, QLD, 4072, Australia.|Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD, 4072, Australia.
authors.forename: Istvan
authors.initials: I
authors.lastname: Toth
authors.affiliation: School of Chemistry and Molecular Biosciences, The University of Queensland, Cooper Road, St. Lucia, QLD, 4072, Australia.
authors.forename: Pavla
authors.initials: P
authors.lastname: Simerska
mesh_terms: D000276:Adjuvants, Immunologic / Q000138:chemical synthesis* / Q000737:chemistry; D000818:Animals; D004797:Enzyme-Linked Immunosorbent Assay; D007074:Immunoglobulin G / Q000097:blood*; D008055:Lipids / Q000138:chemical synthesis / Q000737:chemistry / Q000276:immunology*; D051379:Mice; D010316:Particle Size; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry / Q000276:immunology; D022541:Streptococcal Vaccines / Q000138:chemical synthesis* / Q000737:chemistry / Q000276:immunology*
chemical_list: D000276:Adjuvants, Immunologic; D007074:Immunoglobulin G; D008055:Lipids; D010455:Peptides; D022541:Streptococcal Vaccines
keywords: adjuvant; antigens; immunology; lipopeptide vaccine; toll-like receptor 2