title: Network Metamodeling: Effect of Correlation Metric Choice on Phylogenomic and Transcriptomic Network Topology.
abstract: We explore the use of a network meta-modeling approach to compare the effects of similarity metrics used to construct biological networks on the topology of the resulting networks. This work reviews various similarity metrics for the construction of networks and various topology measures for the characterization of resulting network topology, demonstrating the use of these metrics in the construction and comparison of phylogenomic and transcriptomic networks.
authors.affiliation: Faculty of AgriSciences, Institute for Wine Biotechnology, Stellenbosch University, JH Neethling Building, Victoria Street, 7600, Stellenbosch, South Africa.|The Bredesen Center for Interdisciplinary Research and Graduate Education, University of Tennessee, Knoxville, 444 Greve Hall, 821 Volunteer Blvd., Knoxville, TN, 37996-3394, USA.|Biosciences Division, Oak Ridge National Laboratory, 1 Bethel Valley Road, Oak Ridge, TN, 37831, USA.
authors.forename: Deborah A
authors.initials: DA
authors.lastname: Weighill
authors.affiliation: Faculty of AgriSciences, Institute for Wine Biotechnology, Stellenbosch University, JH Neethling Building, Victoria Street, 7600, Stellenbosch, South Africa. jacobsonda@ornl.gov.|The Bredesen Center for Interdisciplinary Research and Graduate Education, University of Tennessee, Knoxville, 444 Greve Hall, 821 Volunteer Blvd., Knoxville, TN, 37996-3394, USA. jacobsonda@ornl.gov.|Biosciences Division, Oak Ridge National Laboratory, 1 Bethel Valley Road, Oak Ridge, TN, 37831, USA. jacobsonda@ornl.gov.
authors.forename: Daniel
authors.initials: D
authors.lastname: Jacobson
mesh_terms: D000465:Algorithms; D053858:Metabolic Networks and Pathways / Q000502:physiology*; D008954:Models, Biological; D015398:Signal Transduction / Q000502:physiology*; D014157:Transcription Factors / Q000378:metabolism*; D059467:Transcriptome / Q000502:physiology*
chemical_list: D014157:Transcription Factors
keywords: Network comparison; Network topology; Similarity metrics