title: Is In-Stent Restenosis After a Successful Coronary Stent Implantation Due to Stable Angina Associated With TG/HDL-C Ratio?
abstract: We examined the impact of the preprocedural triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) ratio on risk of in-stent restenosis (ISR). Patients with typical anginal symptoms and/or positive treadmill or myocardial perfusion scintigraphy test results who underwent successful coronary stent implantation due to stable angina were examined; 1341 patients were enrolled. The hospital files of the patients were used to gather data. Cox regression analysis showed that the TG/HDL-C ratio was independently associated with the presence of ISR ( P < .001). Moreover, diabetes mellitus ( P = .007), smaller stent diameter ( P = .046), and smoking status ( P = .001) were also independently associated with the presence of ISR. Using a cutoff of 3.8, the TG/HDL-C ratio predicted the presence of ISR with a sensitivity of 71% and a specificity of 68%. Also, the highest quartile of TG/HDL-C ratio had the highest rate of ISR ( P < .001). Measuring preprocedural TG/HDL-C ratio, in fasting or nonfasting samples, could be beneficial for the risk assessment of ISR. However, further large-scale prospective studies are required to establish the exact role of this simple, easily calculated, and reproducible parameter in the pathogenesis of ISR.
authors.affiliation: 1 Cardiology Department, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Harun
authors.initials: H
authors.lastname: Kundi
authors.affiliation: 1 Cardiology Department, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Korkmaz
authors.affiliation: 1 Cardiology Department, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Balun
authors.affiliation: 1 Cardiology Department, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Hulya
authors.initials: H
authors.lastname: Cicekcioglu
authors.affiliation: 1 Cardiology Department, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Emrullah
authors.initials: E
authors.lastname: Kiziltunc
authors.affiliation: 1 Cardiology Department, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Koray
authors.initials: K
authors.lastname: Gursel
authors.affiliation: 1 Cardiology Department, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Cetin
authors.affiliation: 1 Cardiology Department, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Ender
authors.initials: E
authors.lastname: Ornek
authors.affiliation: 1 Cardiology Department, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Ileri
mesh_terms: D000328:Adult; D000368:Aged; D060050:Angina, Stable / Q000601:surgery*; D006348:Cardiac Surgical Procedures; D002784:Cholesterol / Q000097:blood*; D003251:Constriction, Pathologic / Q000601:surgery; D023903:Coronary Restenosis / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D018570:Risk Assessment; D015607:Stents / Q000009:adverse effects; D014280:Triglycerides / Q000097:blood*
chemical_list: D014280:Triglycerides; D002784:Cholesterol
keywords: angina; lipoprotein ratios; stent restenosis; triglyceride to high-density lipoprotein cholesterol ratio