title: Cardiovascular Autonomic Dysfunction in Patients of Nonalcoholic Fatty Liver Disease.
abstract: Aim.The present study was designed to evaluate the heart rate variability (HRV) in nonalcoholic fatty liver disease (NAFLD) and to assess the effect of grade of NAFLD and diabetic status on HRV.Methods.This cross-sectional study included 75 subjects (25 NAFLD without diabetes, 25 NAFLD with diabetes, and 25 controls). Measurements included anthropometry, body composition analysis, estimation of plasma glucose, serum lipids, hsCRP, and serum insulin. HRV analysis was performed in both time and frequency domains.Results.The time and frequency domain indices of overall variability (SDNN, total power) were significantly lower in NAFLD with diabetes as compared to the controls. However, the LF : HF ratio did not differ among the three groups. The variables related to obesity, lipid profile, and glucose metabolism were also higher in NAFLD with diabetes and those with Grade II NAFLD without diabetes, as compared to controls. Multivariate stepwise regression analysis showed a negative correlation between HRV and total cholesterol and fat percentage.Conclusion.The grade of NAFLD as well as diabetic status contributes to the decrease in the cardiovascular autonomic function, with diabetic status rather than grade of NAFLD playing a critical role. Serum lipids and adiposity may also contribute to cardiac autonomic dysfunction.
authors.affiliation: Department of Internal Medicine, All India Institute of Medical Sciences, New Delhi 110029, India.
authors.forename: Mavidi Sunil
authors.initials: MS
authors.lastname: Kumar
authors.affiliation: Department of Physiology, All India Institute of Medical Sciences, New Delhi 110029, India.
authors.forename: Akanksha
authors.initials: A
authors.lastname: Singh
authors.affiliation: Department of Physiology, All India Institute of Medical Sciences, New Delhi 110029, India.
authors.forename: Ashok Kumar
authors.initials: AK
authors.lastname: Jaryal
authors.affiliation: Department of Internal Medicine, All India Institute of Medical Sciences, New Delhi 110029, India.
authors.forename: Piyush
authors.initials: P
authors.lastname: Ranjan
authors.affiliation: Department of Physiology, All India Institute of Medical Sciences, New Delhi 110029, India.
authors.forename: K K
authors.initials: KK
authors.lastname: Deepak
authors.affiliation: Department of Radiodiagnosis, All India Institute of Medical Sciences, New Delhi 110029, India.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Sharma
authors.affiliation: Department of Cardiac Biochemistry, All India Institute of Medical Sciences, New Delhi 110029, India.
authors.forename: R
authors.identifier: 0000-0002-8582-3705
authors.initials: R
authors.lastname: Lakshmy
authors.affiliation: Department of Biostatistics, All India Institute of Medical Sciences, New Delhi 110029, India.
authors.forename: R M
authors.initials: RM
authors.lastname: Pandey
authors.affiliation: Department of Internal Medicine, All India Institute of Medical Sciences, New Delhi 110029, India.
authors.forename: Naval K
authors.identifier: 0000-0002-6202-576X
authors.initials: NK
authors.lastname: Vikram