title: Storage of Red Blood Cells and Transfusion-Related Acute Lung Injury.
abstract: Transfusion-related acute lung injury (TRALI) is a major complication post-transfusion. A consensus definition of TRALI has been recently established to improve diagnosis but the pathogenesis of TRALI is yet to be understood. Although the antibody-mediated two-hit model of TRALI is the classical narrative, increasing evidence of the probable implications of prolonged storage of blood provides novel mechanisms towards storage lesion- the potentially injurious cellular and biochemical changes that occur in stored red blood cells. Red blood cell-derived lipids and micro vesicles may have been playing an important role in the development of TRALI. This article will provide a brief overview of the current understanding of TRALI and then discuss the implications and the potential mechanisms by which stored red blood cells may lead to TRALI.
authors.affiliation: Department of Anesthesia and Department of Physiology, University of Toronto, Canada.
authors.forename: Arkady
authors.initials: A
authors.lastname: Babaev
authors.affiliation: Department of Anesthesia and Department of Physiology, University of Toronto, Canada.
authors.forename: Federico
authors.initials: F
authors.lastname: Pozzi
authors.affiliation: Department of Anesthesia and Department of Physiology, University of Toronto, Canada.
authors.forename: Gregory
authors.initials: G
authors.lastname: Hare
authors.affiliation: Department of Anesthesia and Department of Physiology, University of Toronto, Canada.
authors.forename: Haibo
authors.initials: H
authors.lastname: Zhang
keywords: ARDS; Blood storage; Membrane lipids; Microvesicles