title: Enantioselective Hydrophosphonylation of in Situ Generated N-Acyl Ketimines Catalyzed by BINOL-Derived Phosphoric Acid.
abstract: An efficient route to pharmacologically interesting isoindolinone-based α-amino phosphonates is described via asymmetric hydrophosphonylation of in situ generated ketimines catalyzed by BINOL-derived phosphoric acid. The reaction proceeds smoothly at ambient temperature affording a variety of α-amino phosphonates with a quaternary stereogenic center embedded in isoindolinone motif in high yields with excellent enantiomeric ratios (up to 98.5:1.5 er). Several interesting transformations of the products into valuable synthetic intermediates are also depicted.
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research Bhopal , Bhopal, MP-462 066, India.
authors.forename: Arun
authors.initials: A
authors.lastname: Suneja
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research Bhopal , Bhopal, MP-462 066, India.
authors.forename: Rajshekhar A
authors.initials: RA
authors.lastname: Unhale
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research Bhopal , Bhopal, MP-462 066, India.|Department of Chemistry, Indian Institute of Technology Kanpur , Kanpur, UP-208 016, India.
authors.forename: Vinod K
authors.identifier: 0000-0003-0928-5543
authors.initials: VK
authors.lastname: Singh