title: Dexmedetomidine prevent postoperative nausea and vomiting on patients during general anesthesia: A PRISMA-compliant meta analysis of randomized controlled trials.
abstract: BACKGROUND
  Postoperative nausea and vomiting (PONV) is a frequent complication in postoperative period. The aim of this article was to evaluate the effect of dexmedetomidine on PONV.
  
  
  METHODS
  RevMan 5.3 software was applied for performing statistic analysis. Twenty-four trials with 2046 patients were included.
  
  
  RESULTS
  The PONV of the dexmedetomidine group was significantly lower compared with the placebo group (0.56, 95% CI: 0.46, 0.69). Subgroup analysis further confirmed the effect of dexmedetomidine (irrespective of administration mode) (P < 0.00001). Perioperative fentanyl consumption in dexmedetomidine group were also reduced significantly (P < 0.00001). Whereas, side effects such as bradycardia, hypotension increased in dexmedetomidine group (especially in loading dose mode and loading dose plus continuous infusion mode).
  
  
  CONCLUSIONS
  Dexmedetomidine administrated in continuous infusion mode has the advantage to prevent PONV as well as reduce side effects such as bradycardia and hypotension.
authors.affiliation: Department of Anesthesiology, The first Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
authors.forename: Shenhui
authors.initials: S
authors.lastname: Jin
authors.forename: Dong Dong
authors.initials: DD
authors.lastname: Liang
authors.forename: Chengyu
authors.initials: C
authors.lastname: Chen
authors.forename: Minyuan
authors.initials: M
authors.lastname: Zhang
authors.forename: Junlu
authors.initials: J
authors.lastname: Wang
mesh_terms: D000768:Anesthesia, General / Q000009:adverse effects* / Q000379:methods; D020927:Dexmedetomidine / Q000008:administration & dosage*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage; D007262:Infusions, Intravenous; D010043:Outcome and Process Assessment, Health Care; D020250:Postoperative Nausea and Vomiting / Q000209:etiology / Q000517:prevention & control; D016032:Randomized Controlled Trials as Topic; D013514:Surgical Procedures, Operative / Q000009:adverse effects* / Q000379:methods
chemical_list: D006993:Hypnotics and Sedatives; D020927:Dexmedetomidine