title: Association between plasma proANP and hyperuricemia in Chinese Han women: a cross-sectional study.
abstract: BACKGROUND
  Association between pro-atrial natriuretic peptide (proANP) and hyperuricemia has not yet been investigated in population. This study aimed to examine the association in Chinese Han women.
  
  
  METHODS
  We measured plasma proANP, serum uric acid, and other traditional biomarkers in 1360 women older than 30 years residing in the Gusu district of Suzhou City. Association between plasma proANP and hyperuricemia was analyzed in women aged ≥45 years and those aged <45 years, respectively.
  
  
  RESULTS
  In women aged ≥45 years, the odds ratio (OR) [95% confidence interval (CI)] of hyperuricemia with high proANP (over the median) was 0.57 (0.34-0.97) compared to those with low proANP (p=0.040). After adjustment for age and other potential covariates, a high plasma proANP was associated with a decreased risk of hyperuricemia in women aged ≥45 years (OR 0.40; 95% CI, 0.19-0.84), when the highest and lowest categories were compared. In contrast, there was no association between plasma proANP and hyperuricemia in women aged <45 years. We did not observe a significant interaction between age and proANP (pinteraction=0.113). Sensitivity analyses further confirmed these age-specific findings.
  
  
  CONCLUSIONS
  Plasma proANP was significantly and inversely associated with hyperuricemia in Chinese Han women aged ≥45 years. This study suggests that an increased plasma proANP should be a protective factor of hyperuricemia among middle-aged and old women.
authors.affiliation: .
authors.forename: Zhengbao
authors.initials: Z
authors.lastname: Zhu
authors.affiliation: .
authors.forename: Qiu
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: .
authors.forename: Hao
authors.initials: H
authors.lastname: Peng
authors.affiliation: .
authors.forename: Chongke
authors.initials: C
authors.lastname: Zhong
authors.affiliation: .
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: .
authors.forename: Xinfeng
authors.initials: X
authors.lastname: Huangfu
authors.affiliation: .
authors.forename: Yunfan
authors.initials: Y
authors.lastname: Tian
authors.affiliation: .
authors.forename: Xiangqin
authors.initials: X
authors.lastname: Chao
authors.affiliation: .
authors.forename: Jianhua
authors.initials: J
authors.lastname: Jin
authors.affiliation: .
authors.forename: Yonghong
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D009320:Atrial Natriuretic Factor / Q000097:blood*; D002681:China / Q000208:ethnology; D003430:Cross-Sectional Studies; D005006:Ethnicity; D005260:Female; D006801:Humans; D033461:Hyperuricemia / Q000097:blood*; D008875:Middle Aged; D011498:Protein Precursors / Q000097:blood*; D014527:Uric Acid / Q000097:blood
chemical_list: D011498:Protein Precursors; D014527:Uric Acid; D009320:Atrial Natriuretic Factor
keywords: Chinese; cross-sectional study; hyperuricemia; plasma proANP; serum uric acid