title: Transdifferentiation of Neuroendocrine Cells: Gangliocytoma Associated With Two Pituitary Adenomas of Different Lineage in MEN1.
abstract: Gangliocytomas are rare and benign neuronal cell tumors, mostly found in the hypothalamic and sellar regions. Their histogenesis is still the subject of discussions. Herein we present a unique case of a pituitary gangliocytoma associated with a prolactinoma and a corticotroph adenoma in a patient affected by MEN1. The histologic study revealed shared features between adenomatous and neuronal cells, supporting the etiological hypothesis of a common origin or a phenomenon of transdifferentiation. Furthermore, gangliocytoma could be a new tumor related to MEN1. The clinical and histologic observations are discussed and the literature on the topic is reviewed.
authors.affiliation: Departments of *Endocrinology †Radiology ‡Neurosurgery, Pitié Salpêtrière-Charles Foix Hospital §Department of Neuropathology Raymond-Escourolle, Pitié Salpêtrière-Charles Foix Hospital, INSERM U1127, CNRS UMR 7225, UPMC-Sorbonne University, Brain and Spine Institute ††INSERM U1016, CNRS UMR8104, Paris Descartes University, Cochin Institute, Paris ∥Endocrinology Federation, GH East, Civil Hospital of Lyon, Bron Cedex ¶INSERM U1028, CNRS UMR5292, Lyon 1 University, Neuroscience Center, Lyon **Department of Pathological Cytology and Anatomy, Foch Hospital, Suresnes, France #Department of Endocrinology, CHU de Liège, University of Liège, Liège, Belgium.
authors.forename: Camille
authors.initials: C
authors.lastname: Sergeant
authors.forename: Christel
authors.initials: C
authors.lastname: Jublanc
authors.forename: Delphine
authors.initials: D
authors.lastname: Leclercq
authors.forename: Anne-Laure
authors.initials: AL
authors.lastname: Boch
authors.forename: Franck
authors.initials: F
authors.lastname: Bielle
authors.forename: Gerald
authors.initials: G
authors.lastname: Raverot
authors.forename: Adrian F
authors.initials: AF
authors.lastname: Daly
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Trouillas
authors.forename: Chiara
authors.initials: C
authors.lastname: Villa
mesh_terms: D000236:Adenoma / Q000175:diagnosis / Q000473:pathology*; D054338:Cell Transdifferentiation; D005729:Ganglioneuroma / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D008297:Male; D018761:Multiple Endocrine Neoplasia Type 1 / Q000175:diagnosis / Q000473:pathology*; D055099:Neuroendocrine Cells / Q000473:pathology*; D010911:Pituitary Neoplasms / Q000175:diagnosis / Q000473:pathology*; D015175:Prolactinoma / Q000175:diagnosis / Q000473:pathology*; D055815:Young Adult