title: Improving the Concentrations of the Active Components in the Herbal Tea Ingredient, Uraria crinita: The Effect of Post-harvest Oven-drying Processing.
abstract: Uraria crinita is widely used as a popular folk drink; however, little is known about how the post-harvest operations affect the chemical composition and bioactivity of UC. We assessed three drying methods (Oven-drying, Air-drying, Sun-drying), as well as the Oven-drying temperature using metabolomics approaches and bioactivity assays. The samples processed at 40 degree show a greater effect on the levels of estrogen receptor-alpha activity and nuclear factor erythroid 2-related factor 2 activity, anti-oxidative activity, and cyclooxygenase-2 inhibition compared with the other samples. A multivariate analysis showed a clear separation between the 40 degree Oven-dried samples and the other samples, which is consistent with the results of bioactivity assay. These results are ascribed to at least two-fold increase in the concentrations of flavonoids, spatholosineside A and triterpenoids in the oven-dried samples compared with the other groups. The proposed Oven-drying method at 40 degree results in an improved quality of UC.
authors.affiliation: Institute of Pharmacology, National Yang-Ming University, College of Medicine, Taipei, Taiwan.
authors.forename: Jung
authors.initials: J
authors.lastname: Chao
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
authors.forename: Yuntao
authors.initials: Y
authors.lastname: Dai
authors.affiliation: Department of Nursing, Chung-Jen Junior College of Nursing, Health Sciences and Management, Chia-Yi, Taiwan.
authors.forename: Hao-Yuan
authors.initials: HY
authors.lastname: Cheng
authors.affiliation: Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, United States.
authors.forename: Wing
authors.initials: W
authors.lastname: Lam
authors.affiliation: Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, United States.
authors.forename: Yung-Chi
authors.initials: YC
authors.lastname: Cheng
authors.affiliation: Modern Research Center for Traditional Chinese Medicine of Shanxi University, Shanxi, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Li
authors.affiliation: Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taiwan.
authors.forename: Wen-Huang
authors.initials: WH
authors.lastname: Peng
authors.affiliation: Research Center for Industry of Human Ecology, Graduate Institute of Health-Industry Technology and Department of Nutrition and Health Sciences, Chang Gung University of Science and Technology, Kweishan, Taoyuan, Taiwan.|School of Pharmacy, National Defense Medical Center, Taipei, Taiwan.
authors.forename: Li-Heng
authors.initials: LH
authors.lastname: Pao
authors.affiliation: Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taiwan.
authors.forename: Ming-Tsuen
authors.initials: MT
authors.lastname: Hsieh
authors.affiliation: Modern Research Center for Traditional Chinese Medicine of Shanxi University, Shanxi, China.
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Qin
authors.affiliation: Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taiwan.
authors.forename: Meng-Shiou
authors.initials: MS
authors.lastname: Lee
mesh_terms: D003890:Desiccation / Q000379:methods*; D004339:Drug Compounding / Q000379:methods*; D007887:Fabaceae / Q000737:chemistry*; D005419:Flavonoids / Q000032:analysis; D006027:Glycosides / Q000032:analysis; D064209:Phytochemicals / Q000032:analysis*; D018514:Plant Structures / Q000737:chemistry*; D000069459:Teas, Herbal; D013696:Temperature; D013729:Terpenes / Q000032:analysis
chemical_list: D005419:Flavonoids; D006027:Glycosides; D064209:Phytochemicals; D000069459:Teas, Herbal; D013729:Terpenes; C542618:spatholosineside A