title: Local and Widely Distributed EEG Activity in Schizophrenia With Prevalence of Negative Symptoms.
abstract: We evaluated EEG frequency abnormalities in resting state (eyes closed and eyes open) EEG in a group of chronic schizophrenia patients as compared with healthy subjects. The study included 3 methods of analysis of deviation of EEG characteristics: genuine EEG, current source density (CSD), and group independent component (gIC). All 3 methods have shown that the EEG in schizophrenia patients is characterized by enhanced low-frequency (delta and theta) and high-frequency (beta) activity in comparison with the control group. However, the spatial pattern of differences was dependent on the type of method used. Comparative analysis has shown that increased EEG power in schizophrenia patients apparently concerns both widely spatially distributed components and local components of signal. Furthermore, the observed differences in the delta and theta range can be described mainly by the local components, and those in the beta range mostly by spatially widely distributed ones. The possible nature of the widely distributed activity is discussed.
authors.affiliation: 1 Laboratory of Neurobiology of Action Programming, N.P. Bechtereva Institute of the Human Brain of the Russian Academy of Sciences, St Petersburg, Russia.
authors.forename: Vera A
authors.initials: VA
authors.lastname: Grin-Yatsenko
authors.affiliation: 1 Laboratory of Neurobiology of Action Programming, N.P. Bechtereva Institute of the Human Brain of the Russian Academy of Sciences, St Petersburg, Russia.
authors.forename: Valery A
authors.initials: VA
authors.lastname: Ponomarev
authors.affiliation: 1 Laboratory of Neurobiology of Action Programming, N.P. Bechtereva Institute of the Human Brain of the Russian Academy of Sciences, St Petersburg, Russia.
authors.forename: Marina V
authors.initials: MV
authors.lastname: Pronina
authors.affiliation: 1 Laboratory of Neurobiology of Action Programming, N.P. Bechtereva Institute of the Human Brain of the Russian Academy of Sciences, St Petersburg, Russia.
authors.forename: Yury I
authors.initials: YI
authors.lastname: Poliakov
authors.affiliation: 1 Laboratory of Neurobiology of Action Programming, N.P. Bechtereva Institute of the Human Brain of the Russian Academy of Sciences, St Petersburg, Russia.
authors.forename: Irina V
authors.initials: IV
authors.lastname: Plotnikova
authors.affiliation: 1 Laboratory of Neurobiology of Action Programming, N.P. Bechtereva Institute of the Human Brain of the Russian Academy of Sciences, St Petersburg, Russia.|2 Institute of Psychology, Norwegian University of Science and Technology, Trondheim, Norway.|3 Department of Neuropsychology, Andrzej Frycz Modrzewski Krakow University, Krakow, Poland.
authors.forename: Juri D
authors.initials: JD
authors.lastname: Kropotov
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000503:physiopathology*; D004569:Electroencephalography / Q000379:methods; D005133:Eye Movements / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012559:Schizophrenia / Q000453:epidemiology* / Q000503:physiopathology*; D055815:Young Adult
keywords: EEG spectra; current source density; electroencephalography; group independent component analysis; schizophrenia