title: Sumoylation in Lens Differentiation and Pathogenesis.
abstract: Sumoylation, a post-translational modification discovered over a decade ago, turns out to be a very important regulatory mechanism mediating multiple cellular processes. Recent studies from our laboratory and others also revealed that it plays a crucial role in regulating both differentiation and pathogenesis of the ocular lens. This review will summarize these progresses.
authors.forename: J-W
authors.initials: JW
authors.lastname: Xiang
authors.forename: Z-G
authors.initials: ZG
authors.lastname: Chen
authors.forename: L
authors.initials: L
authors.lastname: Gong
authors.forename: Y
authors.initials: Y
authors.lastname: Xiao
authors.forename: W-J
authors.initials: WJ
authors.lastname: Qing
authors.forename: L
authors.initials: L
authors.lastname: Wang
authors.forename: X-H
authors.initials: XH
authors.lastname: Hu
authors.forename: Z-X
authors.initials: ZX
authors.lastname: Huang
authors.forename: R-L
authors.initials: RL
authors.lastname: Qi
authors.forename: T-H
authors.initials: TH
authors.lastname: Yang
authors.forename: A-P
authors.initials: AP
authors.lastname: Arrigo
authors.forename: L
authors.initials: L
authors.lastname: Zhang
authors.forename: X-C
authors.initials: XC
authors.lastname: Tang
authors.forename: S
authors.initials: S
authors.lastname: Huang
authors.forename: F-Y
authors.initials: FY
authors.lastname: Liu
authors.forename: Z-W
authors.initials: ZW
authors.lastname: Luo
authors.forename: Y-F
authors.initials: YF
authors.lastname: Liu
authors.forename: Q
authors.initials: Q
authors.lastname: Sun
authors.forename: J
authors.initials: J
authors.lastname: Gigantelli
authors.forename: Y-Z
authors.initials: YZ
authors.lastname: Liu
authors.affiliation: Key Laboratory of Protein Chemistry and Developmental Biology of Educational Ministry of China, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081,. China.
authors.forename: D W-C
authors.initials: DW
authors.lastname: Li
mesh_terms: D002386:Cataract / Q000235:genetics* / Q000503:physiopathology; D002454:Cell Differentiation / Q000235:genetics*; D006801:Humans; D007908:Lens, Crystalline / Q000473:pathology; D011499:Protein Processing, Post-Translational / Q000235:genetics*; D058207:Sumoylation / Q000235:genetics*
keywords: Lens; cataractogenesis; differentiation; pathogenesis; sumoylation