title: Thai Fruits Exhibit Antioxidant Activity and Induction of Antioxidant Enzymes in HEK-293 Cells.
abstract: The cellular antioxidant enzymes play the important role of protecting the cells and organisms from the oxidative damage. Natural antioxidants contained in fruits have attracted considerable interest because of their presumed safety and potential nutritional value. Even though antioxidant activities of many fruits have been reported, the effects of phytochemicals contained in fruits on the induction of antioxidant enzymes in the cells have not been fully defined. In this study, we showed that extracts fromAntidesma ghaesembilla,Averrhoa bilimbi,Malpighia glabra,Mangifera indica, Sandoricum koetjape,Syzygium malaccense,andZiziphus jujubainhibited H2O2-induced intracellular reactive oxygen species production in HEK-293 cells. Additionally, these Thai fruit extracts increased the mRNA and protein expressions of antioxidant enzymes, catalase, glutathione peroxidase-1, and manganese superoxide dismutase. The consumption of Thai fruits rich in phenolic compounds may reduce the risk of oxidative stress.
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand.
authors.forename: Natthinee
authors.initials: N
authors.lastname: Anantachoke
authors.affiliation: Department of Food Chemistry, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand.
authors.forename: Pattamapan
authors.initials: P
authors.lastname: Lomarat
authors.affiliation: Department of Food Chemistry, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand.
authors.forename: Wasin
authors.initials: W
authors.lastname: Praserttirachai
authors.affiliation: Department of Pharmacology, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand.
authors.forename: Ruksinee
authors.initials: R
authors.lastname: Khammanit
authors.affiliation: Department of Pharmacology, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand.
authors.forename: Supachoke
authors.identifier: 0000-0003-3223-1551
authors.initials: S
authors.lastname: Mangmool