title: Palladium-catalysed mono-α-alkenylation of ketones with alkenyl tosylates.
abstract: The first example of palladium-catalysed selective mono-α-alkenylation of ketones with alkenyl tosylates is described. In the presence of a Pd/XPhos catalyst system (0.1-1.0 mol%), the reaction provides mono-α-alkenylated ketones in good yields and exhibits excellent substrate tolerance. Highly congested, tri- and tetra-substituted alkenyl tosylates react smoothly and even problematic heteroaryl and aliphatic ketones are applicable substrates. Notably, small β,γ-unsaturated ketones are successfully prepared using acetone as a simple three-carbon feedstock.
authors.affiliation: College of Chemistry and Molecular Sciences, The Institute for Advanced Studies (IAS), Wuhan University, Wuhan 430072, Hubei, P. R. China. aiwenlei@whu.edu.cn.
authors.forename: Yong
authors.initials: Y
authors.lastname: Wu
authors.forename: Wai Chung
authors.initials: WC
authors.lastname: Fu
authors.forename: Chien-Wei
authors.initials: CW
authors.lastname: Chiang
authors.forename: Pui Ying
authors.initials: PY
authors.lastname: Choy
authors.forename: Fuk Yee
authors.initials: FY
authors.lastname: Kwong
authors.forename: Aiwen
authors.initials: A
authors.lastname: Lei