title: Fabrication of redox and pH dual-responsive magnetic graphene oxide microcapsules via sonochemical method.
abstract: In this study, the biocompatible redox and pH dual-responsive magnetic graphene oxide microcapsules (MGOMCs) were prepared by a simple sonochemical method. The disulfide bonds cross-linked the wall of MGOMCs were formed from the hydrosulfuryl on the surface of thiolated graphene oxide, which was synthesized by functionalizing graphene oxide with cysteine, showed an excellent redox-responsive property to control drugs release. Moreover, oleic acid modified Fe3O4nanoparticles were encapsulated into the microcapsules successfully with the hydrophobic drugs dispersed in the hydroxy silicone oil. The MGOMCs possess distinguished magnetic property and pH-responsive ability. Besides, the microcapsules could be engulfed by Hela cells successfully due to the appropriate size and flexible shell. The MGOMCs could be a good carrier for hydrophobic drugs, especially the anticancer drugs.
authors.affiliation: College of Chemistry, Jilin University, Changchun, Jilin 130012, PR China.
authors.forename: Linlin
authors.initials: L
authors.lastname: Dong
authors.affiliation: College of Chemistry, Jilin University, Changchun, Jilin 130012, PR China.
authors.forename: Chao
authors.initials: C
authors.lastname: Shi
authors.affiliation: College of Electronic Science and Engineering, Jilin University, Changchun, Jilin 130012, PR China.
authors.forename: Lanlan
authors.initials: L
authors.lastname: Guo
authors.affiliation: College of Chemistry, Jilin University, Changchun, Jilin 130012, PR China.
authors.forename: Ting
authors.initials: T
authors.lastname: Yang
authors.affiliation: College of Chemistry, Jilin University, Changchun, Jilin 130012, PR China.
authors.forename: Yuexin
authors.initials: Y
authors.lastname: Sun
authors.affiliation: College of Chemistry, Jilin University, Changchun, Jilin 130012, PR China. Electronic address: cui_xj@jlu.edu.cn.
authors.forename: Xuejun
authors.initials: X
authors.lastname: Cui
mesh_terms: D001692:Biological Transport; D002214:Capsules; D004220:Disulfides / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry* / Q000378:metabolism; D065546:Drug Liberation; D006108:Graphite / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D059346:Magnets / Q000737:chemistry*; D010084:Oxidation-Reduction; D010087:Oxides / Q000737:chemistry*; D013010:Sonication; D014867:Water / Q000737:chemistry
chemical_list: D002214:Capsules; D004220:Disulfides; D004337:Drug Carriers; D010087:Oxides; D014867:Water; D006108:Graphite
keywords: Graphene oxide; Magnetic property; Microcapsules; Redox-responsive; Sonochemical; pH-responsive