title: Comparison of catheter ablation for paroxysmal atrial fibrillation between cryoballoon and radiofrequency: a meta-analysis.
abstract: OBJECTIVE
  The present systematic review and meta-analysis aimed to assess and compare the safety and efficacy of radiofrequency (RF) and cryoballoon (CB) ablation for paroxysmal atrial fibrillation (PAF). RF and CB ablation are two frequently used methods for pulmonary vein isolation in PAF, but which is a better choice for PAF remains uncertain.
  
  
  METHODS
  A systematic review was conducted in Medline, PubMed, Embase, and Cochrane Library. All trials comparing RF and CB ablation were screened and included if the inclusion criteria were met.
  
  
  RESULTS
  A total of 38 eligible studies, 9 prospective randomized or randomized controlled trials (RCTs), and 29 non- RCTs were identified, adding up to 15,496 patients. Pool analyses indicated that CB ablation was more beneficial in terms of procedural time [standard mean difference = -0.58; 95% confidence interval (CI), -0.85 to -0.30], complications without phrenic nerve injury (PNI) [odds ratio (OR) = 0.79; 95% CI, 0.67-0.93; I2= 16%], and recrudescence (OR = 0.83; 95% CI, 0.70-0.97; I2= 63%) for PAF; however, the total complications of CB was higher than RF. The subgroup analysis found that, compared with non-contact force radiofrequency (non-CF-RF), both first-generation cryoballoon (CB1) and second-generation cryoballoon (CB2) ablation could reduce complications with PNI, procedural time, and recrudescence. However, the safety and efficacy of CB2 was similar to those of CF-RF.
  
  
  CONCLUSIONS
  Available overall and subgroup data suggested that both CB1 and CB2 were more beneficial than RF ablation, and the main advantages were reflected in comparing them with non-CF-RF. However, CF-RF and CB2 showed similar clinical benefits.
authors.affiliation: Hangzhou First People's Hospital, Nanjing Medical University, Zhejiang Chinese Medical University, #261 Huansha Road, Shangcheng District, Hangzhou, Zhejiang, China.
authors.forename: Chao-Feng
authors.initials: CF
authors.lastname: Chen
authors.affiliation: Hangzhou First People's Hospital, Nanjing Medical University, Zhejiang Chinese Medical University, #261 Huansha Road, Shangcheng District, Hangzhou, Zhejiang, China.
authors.forename: Xiao-Fei
authors.initials: XF
authors.lastname: Gao
authors.affiliation: Hangzhou First People's Hospital, Nanjing Medical University, Zhejiang Chinese Medical University, #261 Huansha Road, Shangcheng District, Hangzhou, Zhejiang, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Duan
authors.affiliation: Hangzhou First People's Hospital, Nanjing Medical University, Zhejiang Chinese Medical University, #261 Huansha Road, Shangcheng District, Hangzhou, Zhejiang, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Chen
authors.affiliation: Hangzhou First People's Hospital, Nanjing Medical University, Zhejiang Chinese Medical University, #261 Huansha Road, Shangcheng District, Hangzhou, Zhejiang, China.
authors.forename: Xiao-Hua
authors.initials: XH
authors.lastname: Liu
authors.affiliation: Hangzhou First People's Hospital, Nanjing Medical University, Zhejiang Chinese Medical University, #261 Huansha Road, Shangcheng District, Hangzhou, Zhejiang, China. njmuzhujue@126.com.|Department of Cardiology, Hangzhou Hospital of Nanjing Medical University, #261 Huansha Road, Hangzhou, Zhejiang Province, China. njmuzhujue@126.com.
authors.forename: Yi-Zhou
authors.initials: YZ
authors.lastname: Xu
mesh_terms: D001281:Atrial Fibrillation / Q000175:diagnosis / Q000453:epidemiology* / Q000601:surgery*; D017115:Catheter Ablation / Q000706:statistics & numerical data*; D003452:Cryosurgery / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000175:diagnosis / Q000453:epidemiology*; D015995:Prevalence; D012307:Risk Factors
keywords: Clinical benefit; Cryoballoon ablation; Meta-analysis; Paroxysmal atrial fibrillation; Radiofrequency ablation