title: Beneficial effect of CETP gene polymorphism in combination with a Mediterranean diet influencing lipid metabolism in metabolic syndrome patients: CORDIOPREV study.
abstract: The cholesteryl ester transfer protein (CETP) gene has been implicated in high-density lipoprotein (HDL-C) metabolism. However, little is known about the impact of this gene on metabolic syndrome (MetS) patients and its interaction with diet. Here, we evaluate whether the consumption of a Mediterranean diet, compared with a Low-fat diet, interacts with the rs3764261 SNP at the CETP locus to modify lipid metabolism in MetS patients. Plasma lipid concentrations and rs3764261 genotypes were determined in 424 MetS subjects participating in the CORDIOPREV clinical trial (NCT00924937). Gene-diet interactions were analyzed after a year of dietary intervention (Mediterranean diet (35% fat, 22% MUFA) vs Low-fat diet (28% fat, 12% MUFA)). We found significant gene-diet interactions between rs3764261 SNP and the dietary pattern for HDL-C (P = 0.006) and triglyceride concentrations (P = 0.040). Specifically, after 12 months of Mediterranean diet intervention, subjects who were carriers of the minor T allele (TT + TG) displayed higher plasma HDL-C concentrations (P = 0.021) and lower triglycerides (P = 0.020) compared with those who were homozygous for the major allele (GG). In contrast, in the Low-fat intervention group, no significant differences were found between CETP genotypes after 12 months of dietary treatment. Our data support the notion that the consumption of a Mediterranean diet may play a contributing role in triggering lipid metabolism by interacting with the rs3764261 SNP at CETP gene locus in MetS patients. Due to the complex nature of gene-environment interactions, dietary adjustment in MetS patients may require a personalized approach.
authors.affiliation: Lipids and Atherosclerosis Unit, IMIBIC/Hospital Universitario Reina Sofía/Universidad de Córdoba and Ciber Fisiopatologia Obesidad y Nutricion, Instituto Salud Carlos III, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Garcia-Rios
authors.affiliation: Lipids and Atherosclerosis Unit, IMIBIC/Hospital Universitario Reina Sofía/Universidad de Córdoba and Ciber Fisiopatologia Obesidad y Nutricion, Instituto Salud Carlos III, Spain.
authors.forename: Juan Francisco
authors.initials: JF
authors.lastname: Alcala-Diaz
authors.affiliation: Lipids and Atherosclerosis Unit, IMIBIC/Hospital Universitario Reina Sofía/Universidad de Córdoba and Ciber Fisiopatologia Obesidad y Nutricion, Instituto Salud Carlos III, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Gomez-Delgado
authors.affiliation: Lipids and Atherosclerosis Unit, IMIBIC/Hospital Universitario Reina Sofía/Universidad de Córdoba and Ciber Fisiopatologia Obesidad y Nutricion, Instituto Salud Carlos III, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Delgado-Lista
authors.affiliation: Lipids and Atherosclerosis Unit, IMIBIC/Hospital Universitario Reina Sofía/Universidad de Córdoba and Ciber Fisiopatologia Obesidad y Nutricion, Instituto Salud Carlos III, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Marin
authors.affiliation: Lipids and Atherosclerosis Unit, IMIBIC/Hospital Universitario Reina Sofía/Universidad de Córdoba and Ciber Fisiopatologia Obesidad y Nutricion, Instituto Salud Carlos III, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Leon-Acuña
authors.affiliation: Lipids and Atherosclerosis Unit, IMIBIC/Hospital Universitario Reina Sofía/Universidad de Córdoba and Ciber Fisiopatologia Obesidad y Nutricion, Instituto Salud Carlos III, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Camargo
authors.affiliation: Clinical Analysis Service, IMIBIC/Hospital Universitario Reina Sofía/Universidad de Córdoba, Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: Rodriguez-Cantalejo
authors.affiliation: Lipids and Atherosclerosis Unit, IMIBIC/Hospital Universitario Reina Sofía/Universidad de Córdoba and Ciber Fisiopatologia Obesidad y Nutricion, Instituto Salud Carlos III, Spain.
authors.forename: Ruth
authors.initials: R
authors.lastname: Blanco-Rojo
authors.affiliation: Lipids and Atherosclerosis Unit, IMIBIC/Hospital Universitario Reina Sofía/Universidad de Córdoba and Ciber Fisiopatologia Obesidad y Nutricion, Instituto Salud Carlos III, Spain.
authors.forename: Gracia
authors.initials: G
authors.lastname: Quintana-Navarro
authors.affiliation: Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University School of Medicine, Boston, MA, USA.
authors.forename: Jose Maria
authors.initials: JM
authors.lastname: Ordovas
authors.affiliation: Lipids and Atherosclerosis Unit, IMIBIC/Hospital Universitario Reina Sofía/Universidad de Córdoba and Ciber Fisiopatologia Obesidad y Nutricion, Instituto Salud Carlos III, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Perez-Jimenez
authors.affiliation: Lipids and Atherosclerosis Unit, IMIBIC/Hospital Universitario Reina Sofía/Universidad de Córdoba and Ciber Fisiopatologia Obesidad y Nutricion, Instituto Salud Carlos III, Spain.
authors.forename: Jose
authors.initials: J
authors.lastname: Lopez-Miranda
authors.affiliation: Lipids and Atherosclerosis Unit, IMIBIC/Hospital Universitario Reina Sofía/Universidad de Córdoba and Ciber Fisiopatologia Obesidad y Nutricion, Instituto Salud Carlos III, Spain. Electronic address: pablopermar@yahoo.es.
authors.forename: Pablo
authors.initials: P
authors.lastname: Perez-Martinez
mesh_terms: D053480:Cholesterol Ester Transfer Proteins / Q000235:genetics*; D038441:Diet, Mediterranean / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D050356:Lipid Metabolism / Q000235:genetics / Q000502:physiology; D008297:Male; D024821:Metabolic Syndrome / Q000178:diet therapy / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics
chemical_list: C506642:CETP protein, human; D053480:Cholesterol Ester Transfer Proteins
keywords: Cholesteryl ester transfer protein polymorphism; Coronary artery disease; Lipid metabolism; Mediterranean diet; Metabolic syndrome; Triglyceride