title: Intraperitoneal cisplatin and doxorubicin as maintenance chemotherapy for unresectable ovarian cancer: a case report.
abstract: Primary advanced, unresectable ovarian cancer (OC) is treated with palliative systemic chemotherapy. Intraperitoneal chemotherapy may be an alternative local maintenance therapy.
  
  
  
  A 75 year old woman with laparoscopically and histologically confirmed unresectable OC was treated with 13 cycles of intraperitoneal cisplatin 7.5 mg/m2and doxorubicin 1.5 mg/m2over 2 years using laparoscopic pressurized intraperitoneal aerosol chemotherapy (PIPAC). Objective tumor response (tumor regression on histology, stable disease on repeated video-laparoscopy and peritoneal carcinomatosis index) was noted. No Common Terminology Criteria for Adverse Events (CTCAE) > grade 3 were observed. EORTC QLQ-C30 quality of life measurements were stable throughout the therapy.
  
  
  
  Repeated intraperitoneal chemotherapy with cisplatin and doxorubicin applied as PIPAC may be an effective maintenance treatment in women with primary advanced, unresectable OC.
authors.affiliation: Department of Obstetrics and Gynecology, Ruhr University Bochum, Bochum, Germany. clemens.tempfer@rub.de.
authors.forename: Clemens B
authors.initials: CB
authors.lastname: Tempfer
authors.affiliation: Department of Pathology, Ruhr University Bochum, Bochum, Germany.
authors.forename: Franziska
authors.initials: F
authors.lastname: Hartmann
authors.affiliation: Department of Obstetrics and Gynecology, Ruhr University Bochum, Bochum, Germany.
authors.forename: Ziad
authors.initials: Z
authors.lastname: Hilal
authors.affiliation: Department of Obstetrics and Gynecology, Ruhr University Bochum, Bochum, Germany.
authors.forename: Günther A
authors.initials: GA
authors.lastname: Rezniczek
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000627:therapeutic use*; D004317:Doxorubicin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D060046:Maintenance Chemotherapy; D010051:Ovarian Neoplasms / Q000188:drug therapy*; D011788:Quality of Life; D016896:Treatment Outcome
chemical_list: D004317:Doxorubicin; D002945:Cisplatin
keywords: Adverse effects; Antineoplastic agents; Intraperitoneal chemotherapy; Maintenance; Ovarian cancer; PIPAC; Peritoneal carcinomatosis; Quality of life