title: [No motor signs in Parkinson's disease].
abstract: In Parkinson's disease, motor signs have long been the main targets of the management of the disease. In recent years, non-motor disorders have elicited increasing interest. These disorders are under diagnosed and managed more difficultly than motor signs and are sometimes perceived as more disturbing by the patients. These signs are polymorphous, sometimes occurring before the motor symptoms but increase with the disease duration and complicating always the late stages. They may fluctuate as the motor signs, while being under the control of dopaminergic pathways, or be linked to the degeneration of other neuronal circuits. These clinical manifestations, whether or not fluctuating are classified into three major categories: psycho-cognitive including sleep disorders, autonomic and sensory.
authors.affiliation: AP-HM, hôpital de la Timone, centre expert pour la maladie de Parkinson, service de neurologie et pathologie du mouvement, 13385 Marseille, France. Electronic address: jean-philippe.azulay@ap-hm.fr.
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Azulay
authors.affiliation: AP-HM, hôpital de la Timone, centre expert pour la maladie de Parkinson, service de neurologie et pathologie du mouvement, 13385 Marseille, France.
authors.forename: Tatiana
authors.initials: T
authors.lastname: Witjas
authors.affiliation: AP-HM, hôpital de la Timone, centre expert pour la maladie de Parkinson, service de neurologie et pathologie du mouvement, 13385 Marseille, France.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Eusebio
mesh_terms: D003072:Cognition Disorders / Q000209:etiology* / Q000503:physiopathology; D003866:Depressive Disorder / Q000209:etiology; D018450:Disease Progression; D059290:Dopaminergic Neurons / Q000502:physiology; D005260:Female; D005767:Gastrointestinal Diseases / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D008297:Male; D009437:Neuralgia / Q000209:etiology / Q000503:physiopathology; D010300:Parkinson Disease / Q000150:complications* / Q000503:physiopathology; D054969:Primary Dysautonomias / Q000209:etiology* / Q000503:physiopathology; D020187:REM Sleep Behavior Disorder / Q000209:etiology / Q000503:physiopathology; D012678:Sensation Disorders / Q000209:etiology* / Q000503:physiopathology; D012737:Sex Factors; D020919:Sleep Disorders, Intrinsic / Q000209:etiology* / Q000503:physiopathology; D063189:Symptom Assessment; D014555:Urination Disorders / Q000209:etiology / Q000503:physiopathology