title: Association of the SPTLC3 rs364585 polymorphism and serum lipid profiles in two Chinese ethnic groups.
abstract: BACKGROUND
  Little is known about the association of the single nucleotide polymorphism (SNP) of rs364585 near serine palmitoyl-transferase long-chain base subunit 3 gene (SPTLC3) and serum lipid profiles. The present study was detected the association of the SPTLC3 rs364585 SNP and several environmental factors with serum lipid profiles in the Han and Jing populations.
  
  
  METHODS
  Genotyping of the SPTLC3 rs364585 SNP was performed in 824 unrelated individuals of Han and 783 participants of Jing by polymerase chain reaction and restriction fragment length polymorphism combined with gel electrophoresis, and then confirmed by direct sequencing.
  
  
  RESULTS
  There was no significant difference in either genotypic or allelic frequencies between Han and Jing, or between males and females of the both ethnic groups. The levels of serum low-density lipoprotein cholesterol (LDL-C) and the ratio of apolipoprotein (Apo) A1 to ApoB in Han; and total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and LDL-C in Jing were different between the A allele carriers and the A allele non-carriers (P < 0.05-0.001). Subgroup analysis according to sex showed that the levels of LDL-C in Han males; TC and LDL-C in Jing males; and HDL-C and LDL-C in Jing females were different between the A allele carriers and the A allele non-carriers (P < 0.05-0.001), the A allele carriers had higher LDL-C and TC levels, and lower HDL-C levels than the A allele non-carriers. Serum lipid traits were also associated with several environmental factors in the Han and Jing populations, or in males and females of the both ethnic groups.
  
  
  CONCLUSIONS
  The present study demonstrates the association between the SPTLC3 rs364585 SNP and serum TC, HDL-C and LDL-C levels in our study populations. These associations might have ethnic- and/or sex-specificity.
  
  
  BACKGROUND
  Retrospectively registered.
authors.affiliation: Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University, 22 Shuangyong Road, Nanning, Guangxi, 530021, People's Republic of China.
authors.forename: Qing-Hui
authors.initials: QH
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University, 22 Shuangyong Road, Nanning, Guangxi, 530021, People's Republic of China. yinruixing@163.com.
authors.forename: Rui-Xing
authors.initials: RX
authors.lastname: Yin
authors.affiliation: Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University, 22 Shuangyong Road, Nanning, Guangxi, 530021, People's Republic of China.
authors.forename: Hui
authors.initials: H
authors.lastname: Gao
authors.affiliation: Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University, 22 Shuangyong Road, Nanning, Guangxi, 530021, People's Republic of China.
authors.forename: Feng
authors.initials: F
authors.lastname: Huang
authors.affiliation: Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University, 22 Shuangyong Road, Nanning, Guangxi, 530021, People's Republic of China.
authors.forename: Jin-Zhen
authors.initials: JZ
authors.lastname: Wu
authors.affiliation: Department of Pathophysiology, School of Premedical Sciences, Guangxi Medical University, Nanning, Guangxi, 530021, People's Republic of China.
authors.forename: Shang-Ling
authors.initials: SL
authors.lastname: Pan
authors.affiliation: Department of Molecular Biology, Medical Scientific Research Center, Guangxi Medical University, Nanning, Guangxi, 530021, People's Republic of China.
authors.forename: Wei-Xiong
authors.initials: WX
authors.lastname: Lin
authors.affiliation: Department of Molecular Biology, Medical Scientific Research Center, Guangxi Medical University, Nanning, Guangxi, 530021, People's Republic of China.
authors.forename: De-Zhai
authors.initials: DZ
authors.lastname: Yang
mesh_terms: D000368:Aged; D016632:Apolipoprotein A-I / Q000097:blood / Q000235:genetics; D053299:Apolipoprotein B-100 / Q000097:blood / Q000235:genetics; D044466:Asian People / Q000235:genetics; D002784:Cholesterol / Q000097:blood / Q000235:genetics; D008076:Cholesterol, HDL / Q000097:blood / Q000235:genetics; D008078:Cholesterol, LDL / Q000097:blood / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005828:Genetics, Population; D006801:Humans; D008055:Lipids / Q000097:blood* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D051102:Serine C-Palmitoyltransferase / Q000235:genetics*
chemical_list: C505693:APOA1 protein, human; C569471:APOB protein, human; D016632:Apolipoprotein A-I; D053299:Apolipoprotein B-100; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D002784:Cholesterol; C521151:SPTLC3 protein, human; D051102:Serine C-Palmitoyltransferase
keywords: Environmental factors; Lipids; Serine palmitoyl-transferase long-chain base subunit 3; Single nucleotide polymorphism