title: Risk of hypertensive disorders in pregnancy following assisted reproductive technology: overview and meta-analysis.
abstract: The extent of the increased risk of pregnancy hypertensive disorders following assisted reproductive technology (ART) was investigated. PubMed and the Cochrane Collaboration Library were used as data sources to identify and select longitudinal cohorts comparing pregnancies following ART with spontaneously conceived pregnancies, between 1978 and June 2016. Risk ratios and 95% confidence intervals (CIs) of three outcomes, ie, gestational hypertension (GH), preeclampsia (PE), and their sum (PHD), were calculated. Stratification of results by gestation order (singletons and nonsingletons) was pursued, but a separate "all orders" mixed stratification was considered. Sixty-six longitudinal studies (7 038 029 pregnancies; 203 375 following any ART) were eligible. All outcomes independent of gestation order ("all orders") were increased following any invasive ART: GH (+79% [95% CI, 24%-157%]) and PE (+75% [95% CI, 50%-103%]) to a greater extent, with smaller increases in PHD (+54% [95% CI, 39%-70%]). The risk of PHD following ART steadily increased independent of gestation order.
authors.affiliation: Department of Cardiology, Helena Venizelou Hospital, Athens, Greece.
authors.forename: Costas
authors.initials: C
authors.lastname: Thomopoulos
authors.affiliation: Department of Obstetrics and Gynecology, Gaia Maternity Hospital, Athens, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Salamalekis
authors.affiliation: First Cardiology Clinic, Hippokration Hospital, Athens University, Athens, Greece.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Kintis
authors.affiliation: Department of Cardiology, Helena Venizelou Hospital, Athens, Greece.
authors.forename: Iliana
authors.initials: I
authors.lastname: Andrianopoulou
authors.affiliation: Department of Cardiology, Helena Venizelou Hospital, Athens, Greece.
authors.forename: Helena
authors.initials: H
authors.lastname: Michalopoulou
authors.affiliation: Department of Cardiology, Helena Venizelou Hospital, Athens, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Skalis
authors.affiliation: Department of Cardiology, Helena Venizelou Hospital, Athens, Greece.
authors.forename: Stefanos
authors.initials: S
authors.lastname: Archontakis
authors.affiliation: Department of Cardiology, Helena Venizelou Hospital, Athens, Greece.
authors.forename: Ourania
authors.initials: O
authors.lastname: Argyri
authors.affiliation: First Cardiology Clinic, Hippokration Hospital, Athens University, Athens, Greece.
authors.forename: Costas
authors.initials: C
authors.lastname: Tsioufis
authors.affiliation: Department of Cardiology, Helena Venizelou Hospital, Athens, Greece.
authors.forename: Thomas K
authors.initials: TK
authors.lastname: Makris
authors.affiliation: Department of Obstetrics and Gynecology, Gaia Maternity Hospital, Athens, Greece.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Salamalekis
mesh_terms: D005260:Female; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000453:epidemiology*; D008137:Longitudinal Studies; D016017:Odds Ratio; D011225:Pre-Eclampsia / Q000453:epidemiology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology; D027724:Reproductive Techniques, Assisted / Q000009:adverse effects*
keywords: assisted pregnancy; gestational hypertension; infertility; preeclampsia; pregnancy-induced hypertension