title: Nailfold capillaroscopic changes in patients with systemic lupus erythematosus: correlations with disease activity, skin manifestation and nephritis.
abstract: Introduction The clinical expression of systemic lupus erythematosus (SLE) is the consequence of endothelial cell damage leading to serious multiple organ dysfunction. The aim of this study was to assess the association between nailfold capillaroscopic changes and disease activity, skin and renal involvement in patients with SLE. Methods Demographic variables, clinical manifestations and laboratory data of 108 patients with SLE were investigated. Nailfold capillaroscopy (NFC) was performed in all patients. Result Morphological changes in NFC were observed in 102 out of 108 (94.4%) SLE patients. Minor changes were found in 33 (30.6%) and major changes in 69 (63.9%) cases. The disease activity was significantly higher in the patients with major changes ( p < 0.002). A higher incidence of microhaemorrhages was seen in patients with active SLE disease ( p < 0.04). In SLE patients with active skin involvement, the disturbed distribution ( p < 0.004) was more frequent and subtle changes ( p < 0.009) were less frequently observed as compared with patients without active skin involvement. In the group of SLE patients with renal involvement, no correlation was found between the capillary abnormalities and the presence of renal involvement ( p > 0.05), except for the elongated capillary loops, which were seen more often in patients with renal involvement than in patients without it ( p < 0.03). Conclusion The results of the study showed that capillary changes (abnormal capillaroscopy) were very common in patients with SLE, although there were no specific patterns like the ones in scleroderma patients, and some changes may be associated with disease activity, especially in patients with active skin involvement.
authors.affiliation: 1 Department of Internal Medicine, Division of Rheumatology, Shiraz University of Medical Sciences, Iran.
authors.forename: S
authors.initials: S
authors.lastname: Shenavandeh
authors.affiliation: 2 School of Medicine, Fasa University of Medical Science, Fasa, Iran.
authors.forename: S
authors.initials: S
authors.lastname: Habibi
mesh_terms: D000328:Adult; D002196:Capillaries / Q000002:abnormalities* / Q000473:pathology / Q000503:physiopathology; D042783:Endothelial Cells / Q000473:pathology; D005260:Female; D006470:Hemorrhage / Q000150:complications* / Q000209:etiology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D020678:Microscopic Angioscopy / Q000379:methods*; D008875:Middle Aged; D009262:Nails / Q000098:blood supply* / Q000473:pathology; D009393:Nephritis / Q000150:complications / Q000473:pathology* / Q000503:physiopathology; D012720:Severity of Illness Index; D012867:Skin / Q000098:blood supply* / Q000473:pathology
keywords: Systemic lupus erythematosus; nailfold capillaroscopy; skin