title: Quantitative genetic analysis of the body composition and blood pressure association in two ethnically diverse populations.
abstract: The major aim of this study was to conduct comparative quantitative-genetic analysis of the body composition (BCP) and somatotype (STP) variation, as well as their correlations with blood pressure (BP) in two ethnically, culturally and geographically different populations: Santhal, indigenous ethnic group from India and Chuvash, indigenous population from Russia.
  
  
  
  Correspondently two pedigree-based samples were collected from 1,262 Santhal and1,558 Chuvash individuals, respectively. At the first stage of the study, descriptive statistics and a series of univariate regression analyses were calculated. Finally, multiple and multivariate regression (MMR) analyses, with BP measurements as dependent variables and age, sex, BCP and STP as independent variables were carried out in each sample separately. The significant and independent covariates of BP were identified and used for re-examination in pedigree-based variance decomposition analysis.
  
  
  
  Despite clear and significant differences between the populations in BCP/STP, both Santhal and Chuvash were found to be predominantly mesomorphic irrespective of their sex. According to MMR analyses variation of BP significantly depended on age and mesomorphic component in both samples, and in addition on sex, ectomorphy and fat mass index in Santhal and on fat free mass index in Chuvash samples, respectively. Additive genetic component contributes to a substantial proportion of blood pressure and body composition variance. Variance component analysis in addition to above mentioned results suggests that additive genetic factors influence BP and BCP/STP associations significantly.
authors.affiliation: Department of Anthropology, North-Eastern Hill University, Shillong, Meghalaya, 793022, India.
authors.forename: Sudipta
authors.identifier: 0000-0002-9803-1475
authors.initials: S
authors.lastname: Ghosh
authors.affiliation: Department of Anatomy, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan.
authors.forename: Tasbulat
authors.initials: T
authors.lastname: Dosaev
authors.affiliation: Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel.
authors.forename: Jai
authors.initials: J
authors.lastname: Prakash
authors.affiliation: Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel.|Lilian and Marcel Pollak Chair of Biological Anthropology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Gregory
authors.initials: G
authors.lastname: Livshits
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure / Q000235:genetics*; D001823:Body Composition / Q000235:genetics*; D003430:Cross-Sectional Studies; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012426:Russia; D013008:Somatotypes / Q000235:genetics*; D044465:White People / Q000235:genetics; D055815:Young Adult
keywords: Chuvash; Santhal; heritability; somatotype components; variance decomposition analysis