title: A new monoterpenoid indole alkaloid from Ochrosia elliptica.
abstract: A new monoterpenoid indole alkaloid, 10-methoxyakuammidine (1), together with four known alkaloids (2-5), were isolated from the stems and leaves of Ochrosia elliptica. The structure of 1 was elucidated by extensive spectroscopic methods and the known compounds were identified by comparisons with data reported in the literature. New compound 1 was evaluated for its cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro. 1 exhibited inhibitory effects with IC50values comparable to those of cisplatin.
authors.affiliation: a College of Pharmacy , Fujian University of Traditional Chinese Medicine , Fuzhou , P. R. China.|b Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education , Hainan Normal University , Haikou , P. R. China.
authors.forename: A-Hong
authors.initials: AH
authors.lastname: Chen
authors.affiliation: a College of Pharmacy , Fujian University of Traditional Chinese Medicine , Fuzhou , P. R. China.|b Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education , Hainan Normal University , Haikou , P. R. China.
authors.forename: Qing-Long
authors.initials: QL
authors.lastname: Liu
authors.affiliation: a College of Pharmacy , Fujian University of Traditional Chinese Medicine , Fuzhou , P. R. China.|b Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education , Hainan Normal University , Haikou , P. R. China.
authors.forename: Yan-Lei
authors.initials: YL
authors.lastname: Ma
authors.affiliation: a College of Pharmacy , Fujian University of Traditional Chinese Medicine , Fuzhou , P. R. China.|b Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education , Hainan Normal University , Haikou , P. R. China.
authors.forename: Zhi-Hua
authors.initials: ZH
authors.lastname: Jiang
authors.affiliation: a College of Pharmacy , Fujian University of Traditional Chinese Medicine , Fuzhou , P. R. China.|b Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education , Hainan Normal University , Haikou , P. R. China.
authors.forename: Jin-Ying
authors.initials: JY
authors.lastname: Tang
authors.affiliation: b Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education , Hainan Normal University , Haikou , P. R. China.
authors.forename: Yan-Ping
authors.initials: YP
authors.lastname: Liu
authors.affiliation: a College of Pharmacy , Fujian University of Traditional Chinese Medicine , Fuzhou , P. R. China.|b Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education , Hainan Normal University , Haikou , P. R. China.
authors.forename: Guang-Ying
authors.initials: GY
authors.lastname: Chen
authors.affiliation: a College of Pharmacy , Fujian University of Traditional Chinese Medicine , Fuzhou , P. R. China.|b Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education , Hainan Normal University , Haikou , P. R. China.
authors.forename: Yan-Hui
authors.initials: YH
authors.lastname: Fu
authors.affiliation: a College of Pharmacy , Fujian University of Traditional Chinese Medicine , Fuzhou , P. R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Xu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D018922:HL-60 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D030011:Ochrosia / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D046948:Secologanin Tryptamine Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D046948:Secologanin Tryptamine Alkaloids
keywords: 10-methoxyakuammidine; Ochrosia elliptica; cytotoxicity; monoterpenoid indole alkaloid