title: Preparation and mineralization of a biocompatible double network hydrogel.
abstract: Double network (DN) hydrogels have shown favorable toughness and strength and been harnessed as scaffolding materials in tissue engineering, particularly, mineralized DN hydrogels may be potential scaffolds in bone tissue engineering. In this paper, DN hydrogels were fabricated from poly(ethylene glycol) diacrylate (PEGDA) and methacrylated poly(γ-glutamic acid) (mPGA). This DN hydrogel not only showed excellent mechanical properties but also good cytocompatibility as evidenced by the characterizations in terms of swelling ratio, mechanical strength/modulus, and cytotoxicity. Further, the DN hydrogels were subjected to mineralization in simulated body fluid, during which hydroxyapatite or analogues formed within the DN hydrogels; the DN hydrogels may be potentially harnessed as bone tissue engineering scaffold.
authors.affiliation: a Department of Polymer Science , College of Chemistry and Molecular Science, Wuhan University , Wuhan , PR China.
authors.forename: Quanzhu
authors.initials: Q
authors.lastname: Yang
authors.affiliation: a Department of Polymer Science , College of Chemistry and Molecular Science, Wuhan University , Wuhan , PR China.
authors.forename: Fangfang
authors.initials: F
authors.lastname: Song
authors.affiliation: a Department of Polymer Science , College of Chemistry and Molecular Science, Wuhan University , Wuhan , PR China.
authors.forename: Xueqing
authors.initials: X
authors.lastname: Zou
authors.affiliation: a Department of Polymer Science , College of Chemistry and Molecular Science, Wuhan University , Wuhan , PR China.
authors.forename: Liqiong
authors.initials: L
authors.lastname: Liao
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D040761:Biomimetic Materials; D002460:Cell Line; D017886:Durapatite / Q000737:chemistry; D020100:Hydrogels / Q000138:chemical synthesis*; D008422:Materials Testing; D011092:Polyethylene Glycols / Q000138:chemical synthesis* / Q000633:toxicity; D011099:Polyglutamic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000633:toxicity; D051381:Rats; D012038:Regeneration; D023822:Tissue Engineering; D054457:Tissue Scaffolds
chemical_list: D001672:Biocompatible Materials; D020100:Hydrogels; C437167:poly(ethylene glycol)diacrylate; C511775:poly(gamma-glutamic acid); D011099:Polyglutamic Acid; D011092:Polyethylene Glycols; D017886:Durapatite
keywords: Double-network; hydrogel; hydroxyapatite; mineralization; poly(ethylene glycol); poly(γ-glutamic acid)