title: Resolving the KgA1c paradox in the management of type 2 diabetes mellitus.
abstract: Excess body weight is a leading cause of metabolic complications such as hypertension and dyslipidemia in T2DM patients. Available antihyperglycemic agents have minimal or no impact on these complications and a majority are known to trigger weight gain, thereby exerting a paradoxical effect on overall metabolic status. This review introduces the concept of 'KgA1c paradox' and underscores the significance of resolving this paradox for comprehensive T2DM management. It provides a therapeutic rationale for inclusion of sodium glucose cotransporter 2 inhibitors in the T2DM treatment algorithm as these agents have demonstrated favorable glycemic effects along with reduction in body weight.
authors.affiliation: Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
authors.forename: Jaime
authors.initials: J
authors.lastname: Davidson
authors.affiliation: Bharti Research Institute of Diabetes & Endocrinology (BRIDE), Karnal, Haryana, India. Electronic address: brideknl@gmail.com.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Kalra
authors.affiliation: Janssen, Pharmaceutical Companies of Johnson & Johnson, Mumbai, Maharashtra, India.
authors.forename: Vikram
authors.initials: V
authors.lastname: Singh
authors.affiliation: Janssen, Pharmaceutical Companies of Johnson & Johnson, Mumbai, Maharashtra, India.
authors.forename: Mayuresh
authors.initials: M
authors.lastname: Fegade
authors.affiliation: Janssen, Pharmaceutical Companies of Johnson & Johnson, Mumbai, Maharashtra, India.
authors.forename: Gursimran
authors.initials: G
authors.lastname: Singh
authors.affiliation: Janssen, Pharmaceutical Companies of Johnson & Johnson, Mumbai, Maharashtra, India.
authors.forename: Amey
authors.initials: A
authors.lastname: Mane
mesh_terms: D000465:Algorithms; D003924:Diabetes Mellitus, Type 2 / Q000517:prevention & control*; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D011237:Predictive Value of Tests
chemical_list: D007004:Hypoglycemic Agents
keywords: Canagliflozin; Dapagliflozin; Empagliflozin; KgA1c paradox; Overweight; SGLT2 inhibitors; Type 2 diabetes mellitus