title: Elevated levels of preβ1-high-density lipoprotein are associated with cholesterol ester transfer protein, the presence and severity of coronary artery disease.
abstract: BACKGROUND
  Preβ1-high-density lipoprotein (preβ1-HDL), plays an important role in reverse cholesterol transport and exhibits potent risk for coronary artery disease (CAD). However, the association of plasma preβ1-HDL and cholesterol ester transfer protein (CETP) levels in CAD patients and the relationship of preβ1-HDL with extent of CAD are debatable.
  
  
  METHODS
  Preβ1-HDL and CETP levels were measured by enzymed-linked immunosorbent assay (ELISAs) in 88 acute coronary syndromes (ACS), 79 stable coronary artery disease (SCAD) patients and 85 control subjects. The correlation analyses, multiple linear regression analyses and logistic regression analyses were performed, respectively.
  
  
  RESULTS
  The preβ1-HDL and CETP levels in ACS patients were significantly higher than those in SCAD patients and both of them were higher than controls'. Preβ1-HDL levels were positively associated with CETP (R = 0.348, P = 0.000), the diameter of stenosis (R = 0.253, P = 0.005), the number of vessel disease (R = 0.274, P = 0.002) and Gensini score (R = 0.227, P = 0.009) in CAD patients. Stepwise multiple linear regression analyses showed that CETP was one of the determinants of preβ1-HDL levels. Logistic regression analysis revealed that elevated preβ1-HDL and CETP were potential risk factors for both ACS and SCAD.
  
  
  CONCLUSIONS
  The elevated preβ1-HDL levels may change with CETP concentrations in CAD patients and were related to the presence and severity of CAD.
authors.affiliation: Department of Clinical Laboratory, Jinling Hospital, School of Medicine, Nanjing University, 305East Zhongshan Rd., Nanjing, 210002, China.
authors.forename: Xiao-Min
authors.initials: XM
authors.lastname: Bu
authors.affiliation: Department of Clinical Laboratory, Jinling Hospital, School of Medicine, Nanjing University, 305East Zhongshan Rd., Nanjing, 210002, China.
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Niu
authors.affiliation: Department of Clinical Laboratory, Jinling Hospital, School of Medicine, Nanjing University, 305East Zhongshan Rd., Nanjing, 210002, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Clinical Laboratory, Jinling Hospital, School of Medicine, Nanjing University, 305East Zhongshan Rd., Nanjing, 210002, China.
authors.forename: Yun-Long
authors.initials: YL
authors.lastname: Yuan
authors.affiliation: Department of Clinical Laboratory, Jinling Hospital, School of Medicine, Nanjing University, 305East Zhongshan Rd., Nanjing, 210002, China. strive1225@126.com.
authors.forename: Jia-Xi
authors.initials: JX
authors.lastname: Song
authors.affiliation: Department of Clinical Laboratory, Jinling Hospital, School of Medicine, Nanjing University, 305East Zhongshan Rd., Nanjing, 210002, China. wangjunjun9202@163.com.
authors.forename: Jun-Jun
authors.initials: JJ
authors.lastname: Wang
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D053480:Cholesterol Ester Transfer Proteins / Q000097:blood*; D003324:Coronary Artery Disease / Q000097:blood* / Q000209:etiology; D005260:Female; D053442:High-Density Lipoproteins, Pre-beta / Q000097:blood*; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D015415:Biomarkers; C506642:CETP protein, human; D053480:Cholesterol Ester Transfer Proteins; D053442:High-Density Lipoproteins, Pre-beta; D008055:Lipids
keywords: Atherosclerosis; CETP; Coronary artery disease; Preβ1-HDL