title: [Possibility of progesterone as the diagnostic biomarker of 21-hydroxylase deficiency].
abstract: Objective:To explore the diagnostic value of progesterone in 21-hydroxylase deficiency (21-OHD).Methods:One hundred and ninety-three patients (female: 127, male: 66) with 21-OHD were recruited at Peking Union Medical College Hospital between January and December 2015. At the same time, 253 patients (female: 162, male: 91) with other disease were included as control, and their sex hormone and 17-OHP were measured simultaneously. The correlation between 17-alpha-hydroxyprogesterone (17-OHP) and progesterone was analyzed and the probability of progesterone as the diagnostic biomarker of 21-OHD was determined.Results:There was obvious positive correlation between progesterone and 17-OHP levels in subjects with different age and gender, and the correlation coefficient was from 0.775 to 0.878 (allP<0.001). Receiver operating characteristic curve (ROC) analysis showed that the area under curve was from 0.930 to 1.000 (allP<0.001) when using progesterone as the diagnostic biomarker.Conclusions:Obvious positive correlation exists between progesterone and 17-OHP in patients with 21-OHD. The measurement of progesterone can be an assistant method for the diagnosis of 21-OHD.
authors.affiliation: Key Laboratory of Endocrinology of National Health and Family Planning Commission, Beijing 100730, China.
authors.forename: M
authors.initials: M
authors.lastname: Nie
authors.forename: M X
authors.initials: MX
authors.lastname: Cui
authors.forename: J F
authors.initials: JF
authors.lastname: Mao
authors.forename: A L
authors.initials: AL
authors.lastname: Tong
authors.forename: S
authors.initials: S
authors.lastname: Chen
authors.forename: X
authors.initials: X
authors.lastname: Wang
authors.forename: L
authors.initials: L
authors.lastname: Lu
authors.forename: X Y
authors.initials: XY
authors.lastname: Wu
mesh_terms: D019326:17-alpha-Hydroxyprogesterone; D000312:Adrenal Hyperplasia, Congenital / Q000175:diagnosis*; D015415:Biomarkers; D005260:Female; D006801:Humans; D008297:Male; D011374:Progesterone
chemical_list: D015415:Biomarkers; D011374:Progesterone; D019326:17-alpha-Hydroxyprogesterone