title: The genetics, biosynthesis and regulation of toxic specialized metabolites of cyanobacteria.
abstract: The production of toxic metabolites by cyanobacterial blooms represents a significant threat to the health of humans and ecosystems worldwide. Here we summarize the current state of the knowledge regarding the genetics, biosynthesis and regulation of well-characterized cyanotoxins, including the microcystins, nodularin, cylindrospermopsin, saxitoxins and anatoxins, as well as the lesser-known marine toxins (e.g. lyngbyatoxin, aplysiatoxin, jamaicamides, barbamide, curacin, hectochlorin and apratoxins).
authors.affiliation: Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney 2052, NSW, Australia.
authors.forename: Leanne A
authors.initials: LA
authors.lastname: Pearson
authors.affiliation: Institut für Biochemie und Biologie, Mikrobiologie, Universität Potsdam, Potsdam-Golm 14476, Germany.
authors.forename: Elke
authors.initials: E
authors.lastname: Dittmann
authors.affiliation: Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney 2052, NSW, Australia.
authors.forename: Rabia
authors.initials: R
authors.lastname: Mazmouz
authors.affiliation: Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney 2052, NSW, Australia.
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Ongley
authors.affiliation: Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney 2052, NSW, Australia.
authors.forename: Paul M
authors.initials: PM
authors.lastname: D'Agostino
authors.affiliation: Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney 2052, NSW, Australia. Electronic address: b.neilan@unsw.edu.au.
authors.forename: Brett A
authors.initials: BA
authors.lastname: Neilan
mesh_terms: D001427:Bacterial Toxins / Q000096:biosynthesis* / Q000235:genetics* / Q000378:metabolism; D000458:Cyanobacteria / Q000235:genetics / Q000502:physiology*; D017753:Ecosystem; D015964:Gene Expression Regulation, Bacterial; D006801:Humans
chemical_list: D001427:Bacterial Toxins
keywords: Biosynthesis; Cyanobacteria; Cyanotoxins; Genetics; Regulation; Specialized metabolites