title: Brief cognitive-behavioural therapy for patients in the community with schizophrenia: randomised controlled trial in Beijing, China.
abstract: BackgroundBrief cognitive-behavioural therapy (CBT) is an emerging treatment for schizophrenia in community settings; however, further trials are needed, especially in non-Western countries.AimsTo test the effects of brief CBT for Chinese patients with schizophrenia in the community (trial registration: ChiCTR-TRC-13003709).MethodA total of 220 patients with schizophrenia from four districts of Beijing were randomly assigned to either brief CBT plus treatment as usual (TAU) or TAU alone. Patients were assessed at baseline, post-treatment and at 6- and 12-month follow-ups by raters masked to group allocation.ResultsAt the post-treatment assessment and the 12-month follow-up, patients who received brief CBT showed greater improvement in overall symptoms, general psychopathology, insight and social functioning. In total, 37.3% of those in the brief CBT plus TAU group experienced a clinically significant response, compared with only 19.1% of those in the TAU alone group (P= 0.003).ConclusionsBrief CBT has a positive effect on Chinese patients with schizophrenia in the community.
authors.affiliation: Zhi-Hua Guo, MD, Zhan-Jiang Li, MD, PhD, Yun Ma, MSc, Department of Clinical Psychology & Beijing Key Lab of Mental Disorders, Beijing Anding Hospital, Capital Medical University, and Centre of Schizophrenia, Beijing Institute for Brain Disorders, Beijing, People's Republic of China; Jing Sun, PhD, Menzies Health Institute Queensland and School of Medicine, Griffith University, Queensland, Australia; Jun-Hua Guo, MD, Department of Psychiatry, Beijing Anding Hospital, Capital Medical University, Beijing, People's Republic of China; Wen-Xiu Li, MD, Mental Health Prevention Hospital of Haidian District, Beijing, People's Republic of China; Zhi-Qiang Wang, MD, Dongcheng District Stadium Road Community Health Care Centre, Beijing, People's Republic of China; Hui-Li Xu, MD, Chaoyang District Centre for Mental Disease Control and Prevention, Beijing, People's Republic of China; Roger M. K. Ng, MD, PhD, Department of Psychiatry, Kowloon Hospital, Hong Kong, People's Republic of China; Douglas Turkington, MD, MRCPsych, Newcastle University, Newcastle-on-Tyne, UK; David Kingdon, MD, MRCPsych, Department of Psychiatry, University of Southampton, Southampton, UK.
authors.forename: Zhi-Hua
authors.initials: ZH
authors.lastname: Guo
authors.affiliation: Zhi-Hua Guo, MD, Zhan-Jiang Li, MD, PhD, Yun Ma, MSc, Department of Clinical Psychology & Beijing Key Lab of Mental Disorders, Beijing Anding Hospital, Capital Medical University, and Centre of Schizophrenia, Beijing Institute for Brain Disorders, Beijing, People's Republic of China; Jing Sun, PhD, Menzies Health Institute Queensland and School of Medicine, Griffith University, Queensland, Australia; Jun-Hua Guo, MD, Department of Psychiatry, Beijing Anding Hospital, Capital Medical University, Beijing, People's Republic of China; Wen-Xiu Li, MD, Mental Health Prevention Hospital of Haidian District, Beijing, People's Republic of China; Zhi-Qiang Wang, MD, Dongcheng District Stadium Road Community Health Care Centre, Beijing, People's Republic of China; Hui-Li Xu, MD, Chaoyang District Centre for Mental Disease Control and Prevention, Beijing, People's Republic of China; Roger M. K. Ng, MD, PhD, Department of Psychiatry, Kowloon Hospital, Hong Kong, People's Republic of China; Douglas Turkington, MD, MRCPsych, Newcastle University, Newcastle-on-Tyne, UK; David Kingdon, MD, MRCPsych, Department of Psychiatry, University of Southampton, Southampton, UK lizhj8@ccmu.edu.cn.
authors.forename: Zhan-Jiang
authors.initials: ZJ
authors.lastname: Li
authors.affiliation: Zhi-Hua Guo, MD, Zhan-Jiang Li, MD, PhD, Yun Ma, MSc, Department of Clinical Psychology & Beijing Key Lab of Mental Disorders, Beijing Anding Hospital, Capital Medical University, and Centre of Schizophrenia, Beijing Institute for Brain Disorders, Beijing, People's Republic of China; Jing Sun, PhD, Menzies Health Institute Queensland and School of Medicine, Griffith University, Queensland, Australia; Jun-Hua Guo, MD, Department of Psychiatry, Beijing Anding Hospital, Capital Medical University, Beijing, People's Republic of China; Wen-Xiu Li, MD, Mental Health Prevention Hospital of Haidian District, Beijing, People's Republic of China; Zhi-Qiang Wang, MD, Dongcheng District Stadium Road Community Health Care Centre, Beijing, People's Republic of China; Hui-Li Xu, MD, Chaoyang District Centre for Mental Disease Control and Prevention, Beijing, People's Republic of China; Roger M. K. Ng, MD, PhD, Department of Psychiatry, Kowloon Hospital, Hong Kong, People's Republic of China; Douglas Turkington, MD, MRCPsych, Newcastle University, Newcastle-on-Tyne, UK; David Kingdon, MD, MRCPsych, Department of Psychiatry, University of Southampton, Southampton, UK.
authors.forename: Yun
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Zhi-Hua Guo, MD, Zhan-Jiang Li, MD, PhD, Yun Ma, MSc, Department of Clinical Psychology & Beijing Key Lab of Mental Disorders, Beijing Anding Hospital, Capital Medical University, and Centre of Schizophrenia, Beijing Institute for Brain Disorders, Beijing, People's Republic of China; Jing Sun, PhD, Menzies Health Institute Queensland and School of Medicine, Griffith University, Queensland, Australia; Jun-Hua Guo, MD, Department of Psychiatry, Beijing Anding Hospital, Capital Medical University, Beijing, People's Republic of China; Wen-Xiu Li, MD, Mental Health Prevention Hospital of Haidian District, Beijing, People's Republic of China; Zhi-Qiang Wang, MD, Dongcheng District Stadium Road Community Health Care Centre, Beijing, People's Republic of China; Hui-Li Xu, MD, Chaoyang District Centre for Mental Disease Control and Prevention, Beijing, People's Republic of China; Roger M. K. Ng, MD, PhD, Department of Psychiatry, Kowloon Hospital, Hong Kong, People's Republic of China; Douglas Turkington, MD, MRCPsych, Newcastle University, Newcastle-on-Tyne, UK; David Kingdon, MD, MRCPsych, Department of Psychiatry, University of Southampton, Southampton, UK.
authors.forename: Jing
authors.initials: J
authors.lastname: Sun
authors.affiliation: Zhi-Hua Guo, MD, Zhan-Jiang Li, MD, PhD, Yun Ma, MSc, Department of Clinical Psychology & Beijing Key Lab of Mental Disorders, Beijing Anding Hospital, Capital Medical University, and Centre of Schizophrenia, Beijing Institute for Brain Disorders, Beijing, People's Republic of China; Jing Sun, PhD, Menzies Health Institute Queensland and School of Medicine, Griffith University, Queensland, Australia; Jun-Hua Guo, MD, Department of Psychiatry, Beijing Anding Hospital, Capital Medical University, Beijing, People's Republic of China; Wen-Xiu Li, MD, Mental Health Prevention Hospital of Haidian District, Beijing, People's Republic of China; Zhi-Qiang Wang, MD, Dongcheng District Stadium Road Community Health Care Centre, Beijing, People's Republic of China; Hui-Li Xu, MD, Chaoyang District Centre for Mental Disease Control and Prevention, Beijing, People's Republic of China; Roger M. K. Ng, MD, PhD, Department of Psychiatry, Kowloon Hospital, Hong Kong, People's Republic of China; Douglas Turkington, MD, MRCPsych, Newcastle University, Newcastle-on-Tyne, UK; David Kingdon, MD, MRCPsych, Department of Psychiatry, University of Southampton, Southampton, UK.
authors.forename: Jun-Hua
authors.initials: JH
authors.lastname: Guo
authors.affiliation: Zhi-Hua Guo, MD, Zhan-Jiang Li, MD, PhD, Yun Ma, MSc, Department of Clinical Psychology & Beijing Key Lab of Mental Disorders, Beijing Anding Hospital, Capital Medical University, and Centre of Schizophrenia, Beijing Institute for Brain Disorders, Beijing, People's Republic of China; Jing Sun, PhD, Menzies Health Institute Queensland and School of Medicine, Griffith University, Queensland, Australia; Jun-Hua Guo, MD, Department of Psychiatry, Beijing Anding Hospital, Capital Medical University, Beijing, People's Republic of China; Wen-Xiu Li, MD, Mental Health Prevention Hospital of Haidian District, Beijing, People's Republic of China; Zhi-Qiang Wang, MD, Dongcheng District Stadium Road Community Health Care Centre, Beijing, People's Republic of China; Hui-Li Xu, MD, Chaoyang District Centre for Mental Disease Control and Prevention, Beijing, People's Republic of China; Roger M. K. Ng, MD, PhD, Department of Psychiatry, Kowloon Hospital, Hong Kong, People's Republic of China; Douglas Turkington, MD, MRCPsych, Newcastle University, Newcastle-on-Tyne, UK; David Kingdon, MD, MRCPsych, Department of Psychiatry, University of Southampton, Southampton, UK.
authors.forename: Wen-Xiu
authors.initials: WX
authors.lastname: Li
authors.affiliation: Zhi-Hua Guo, MD, Zhan-Jiang Li, MD, PhD, Yun Ma, MSc, Department of Clinical Psychology & Beijing Key Lab of Mental Disorders, Beijing Anding Hospital, Capital Medical University, and Centre of Schizophrenia, Beijing Institute for Brain Disorders, Beijing, People's Republic of China; Jing Sun, PhD, Menzies Health Institute Queensland and School of Medicine, Griffith University, Queensland, Australia; Jun-Hua Guo, MD, Department of Psychiatry, Beijing Anding Hospital, Capital Medical University, Beijing, People's Republic of China; Wen-Xiu Li, MD, Mental Health Prevention Hospital of Haidian District, Beijing, People's Republic of China; Zhi-Qiang Wang, MD, Dongcheng District Stadium Road Community Health Care Centre, Beijing, People's Republic of China; Hui-Li Xu, MD, Chaoyang District Centre for Mental Disease Control and Prevention, Beijing, People's Republic of China; Roger M. K. Ng, MD, PhD, Department of Psychiatry, Kowloon Hospital, Hong Kong, People's Republic of China; Douglas Turkington, MD, MRCPsych, Newcastle University, Newcastle-on-Tyne, UK; David Kingdon, MD, MRCPsych, Department of Psychiatry, University of Southampton, Southampton, UK.
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Wang
authors.affiliation: Zhi-Hua Guo, MD, Zhan-Jiang Li, MD, PhD, Yun Ma, MSc, Department of Clinical Psychology & Beijing Key Lab of Mental Disorders, Beijing Anding Hospital, Capital Medical University, and Centre of Schizophrenia, Beijing Institute for Brain Disorders, Beijing, People's Republic of China; Jing Sun, PhD, Menzies Health Institute Queensland and School of Medicine, Griffith University, Queensland, Australia; Jun-Hua Guo, MD, Department of Psychiatry, Beijing Anding Hospital, Capital Medical University, Beijing, People's Republic of China; Wen-Xiu Li, MD, Mental Health Prevention Hospital of Haidian District, Beijing, People's Republic of China; Zhi-Qiang Wang, MD, Dongcheng District Stadium Road Community Health Care Centre, Beijing, People's Republic of China; Hui-Li Xu, MD, Chaoyang District Centre for Mental Disease Control and Prevention, Beijing, People's Republic of China; Roger M. K. Ng, MD, PhD, Department of Psychiatry, Kowloon Hospital, Hong Kong, People's Republic of China; Douglas Turkington, MD, MRCPsych, Newcastle University, Newcastle-on-Tyne, UK; David Kingdon, MD, MRCPsych, Department of Psychiatry, University of Southampton, Southampton, UK.
authors.forename: Hui-Li
authors.initials: HL
authors.lastname: Xu
authors.affiliation: Zhi-Hua Guo, MD, Zhan-Jiang Li, MD, PhD, Yun Ma, MSc, Department of Clinical Psychology & Beijing Key Lab of Mental Disorders, Beijing Anding Hospital, Capital Medical University, and Centre of Schizophrenia, Beijing Institute for Brain Disorders, Beijing, People's Republic of China; Jing Sun, PhD, Menzies Health Institute Queensland and School of Medicine, Griffith University, Queensland, Australia; Jun-Hua Guo, MD, Department of Psychiatry, Beijing Anding Hospital, Capital Medical University, Beijing, People's Republic of China; Wen-Xiu Li, MD, Mental Health Prevention Hospital of Haidian District, Beijing, People's Republic of China; Zhi-Qiang Wang, MD, Dongcheng District Stadium Road Community Health Care Centre, Beijing, People's Republic of China; Hui-Li Xu, MD, Chaoyang District Centre for Mental Disease Control and Prevention, Beijing, People's Republic of China; Roger M. K. Ng, MD, PhD, Department of Psychiatry, Kowloon Hospital, Hong Kong, People's Republic of China; Douglas Turkington, MD, MRCPsych, Newcastle University, Newcastle-on-Tyne, UK; David Kingdon, MD, MRCPsych, Department of Psychiatry, University of Southampton, Southampton, UK.
authors.forename: Roger M K
authors.initials: RM
authors.lastname: Ng
authors.affiliation: Zhi-Hua Guo, MD, Zhan-Jiang Li, MD, PhD, Yun Ma, MSc, Department of Clinical Psychology & Beijing Key Lab of Mental Disorders, Beijing Anding Hospital, Capital Medical University, and Centre of Schizophrenia, Beijing Institute for Brain Disorders, Beijing, People's Republic of China; Jing Sun, PhD, Menzies Health Institute Queensland and School of Medicine, Griffith University, Queensland, Australia; Jun-Hua Guo, MD, Department of Psychiatry, Beijing Anding Hospital, Capital Medical University, Beijing, People's Republic of China; Wen-Xiu Li, MD, Mental Health Prevention Hospital of Haidian District, Beijing, People's Republic of China; Zhi-Qiang Wang, MD, Dongcheng District Stadium Road Community Health Care Centre, Beijing, People's Republic of China; Hui-Li Xu, MD, Chaoyang District Centre for Mental Disease Control and Prevention, Beijing, People's Republic of China; Roger M. K. Ng, MD, PhD, Department of Psychiatry, Kowloon Hospital, Hong Kong, People's Republic of China; Douglas Turkington, MD, MRCPsych, Newcastle University, Newcastle-on-Tyne, UK; David Kingdon, MD, MRCPsych, Department of Psychiatry, University of Southampton, Southampton, UK.
authors.forename: Douglas
authors.initials: D
authors.lastname: Turkington
authors.affiliation: Zhi-Hua Guo, MD, Zhan-Jiang Li, MD, PhD, Yun Ma, MSc, Department of Clinical Psychology & Beijing Key Lab of Mental Disorders, Beijing Anding Hospital, Capital Medical University, and Centre of Schizophrenia, Beijing Institute for Brain Disorders, Beijing, People's Republic of China; Jing Sun, PhD, Menzies Health Institute Queensland and School of Medicine, Griffith University, Queensland, Australia; Jun-Hua Guo, MD, Department of Psychiatry, Beijing Anding Hospital, Capital Medical University, Beijing, People's Republic of China; Wen-Xiu Li, MD, Mental Health Prevention Hospital of Haidian District, Beijing, People's Republic of China; Zhi-Qiang Wang, MD, Dongcheng District Stadium Road Community Health Care Centre, Beijing, People's Republic of China; Hui-Li Xu, MD, Chaoyang District Centre for Mental Disease Control and Prevention, Beijing, People's Republic of China; Roger M. K. Ng, MD, PhD, Department of Psychiatry, Kowloon Hospital, Hong Kong, People's Republic of China; Douglas Turkington, MD, MRCPsych, Newcastle University, Newcastle-on-Tyne, UK; David Kingdon, MD, MRCPsych, Department of Psychiatry, University of Southampton, Southampton, UK.
authors.forename: David
authors.initials: D
authors.lastname: Kingdon
mesh_terms: D000328:Adult; D000068476:Beijing; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D011614:Psychotherapy, Brief / Q000379:methods*; D012559:Schizophrenia