title: Diurnal Variations in Neural Activity of Healthy Human Brain Decoded with Resting-State Blood Oxygen Level Dependent fMRI.
abstract: It remains an ongoing investigation about how the neural activity alters with the diurnal rhythms in human brain. Resting-state functional magnetic resonance imaging (RS-fMRI) reflects spontaneous activities and/or the endogenous neurophysiological process of the human brain. In the present study, we applied the ReHo (regional homogeneity) and ALFF (amplitude of low frequency fluctuation) based on RS-fMRI to explore the regional differences in the spontaneous cerebral activities throughout the entire brain between the morning and evening sessions within a 24-h time cycle. Wide spread brain areas were found to exhibit diurnal variations, which may be attributed to the internal molecular systems regulated by clock genes, and the environmental factors including light-dark cycle, daily activities and homeostatic sleep drive. Notably, the diurnal variation of default mode network (DMN) suggests that there is an adaptation or compensation response within the subregions of DMN, implying a balance or a decoupling of regulation between these regions.
authors.affiliation: Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences Shenzhen, China.
authors.forename: Chunxiang
authors.initials: C
authors.lastname: Jiang
authors.affiliation: Department of Neurology, Peking University Shenzhen Hospital Shenzhen, China.
authors.forename: Li
authors.initials: L
authors.lastname: Yi
authors.affiliation: Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences Shenzhen, China.
authors.forename: Shi
authors.initials: S
authors.lastname: Su
authors.affiliation: Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences Shenzhen, China.
authors.forename: Caiyun
authors.initials: C
authors.lastname: Shi
authors.affiliation: Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences Shenzhen, China.
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Long
authors.affiliation: Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences Shenzhen, China.
authors.forename: Guoxi
authors.initials: G
authors.lastname: Xie
authors.affiliation: Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences Shenzhen, China.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Zhang
keywords: ALFF; ReHo; diurnal rhythm; fMRI; neural activity