title: To Study and Determine the Role of Anterior Segment Optical Coherence Tomography and Ultrasound Biomicroscopy in Corneal and Conjunctival Tumors.
abstract: Purpose. To analyze and describe corneal and conjunctival tumor thickness and internal characteristics and extension in depth and size and shape measured by two noninvasive techniques, anterior segment optical coherence tomography (AS-OCT) and ultrasound biomicroscopy (UBM).Design. Systematic review.Methods. This systematic review is based on a comprehensive search of 4 databases (Medline, Embase, Web of Science, and Cochrane Library). Articles published between January 1, 1999, and December 31, 2015, were included. We searched for articles using the following search terms in various combinations: "optical coherence tomography", "ultrasound biomicroscopy", "corneal neoplasm", "conjunctival neoplasm", "eye", "tumor" and "anterior segment tumors". Inclusion criteria were as follows: UBM and/or AS-OCT was used; the study included corneal or conjunctival tumors; and the article was published in English, French, Dutch, or German.Results. There were 14 sources selected.Discussion. Several studies on the quality of AS-OCT and UBM show that these imaging techniques provide useful information about the internal features, extension, size, and shape of tumors. Yet there is no enough evidence on the advantages and disadvantages of UBM and AS-OCT in certain tumor types.Conclusion. More comparative studies are needed to investigate which imaging technique is most suitable for a certain tumor type.
authors.affiliation: University of Antwerp, Antwerp, Belgium.
authors.forename: Katleen
authors.initials: K
authors.lastname: Janssens
authors.affiliation: University of Antwerp, Antwerp, Belgium.
authors.forename: Michelle
authors.identifier: 0000-0002-3003-5410
authors.initials: M
authors.lastname: Mertens
authors.affiliation: Department of Ophthalmology, University Hospital Antwerp, Edegem, Belgium.
authors.forename: Noémie
authors.initials: N
authors.lastname: Lauwers
authors.affiliation: Department of Ophthalmology, University Hospital Antwerp, Edegem, Belgium; Department of Ophthalmology, LUMC, Leiden, Netherlands.
authors.forename: Rob J W
authors.initials: RJ
authors.lastname: de Keizer
authors.affiliation: University of Antwerp, Antwerp, Belgium; Department of Ophthalmology, University Hospital Antwerp, Edegem, Belgium.
authors.forename: Danny G P
authors.initials: DG
authors.lastname: Mathysen
authors.affiliation: University of Antwerp, Antwerp, Belgium; Department of Ophthalmology, University Hospital Antwerp, Edegem, Belgium.
authors.forename: Veva
authors.identifier: 0000-0003-3445-6295
authors.initials: V
authors.lastname: De Groot