title: Interplay of extracellular matrix and leukocytes in lung inflammation.
abstract: During inflammation, leukocytes influx into lung compartments and interact with extracellular matrix (ECM). Two ECM components, versican and hyaluronan, increase in a range of lung diseases. The interaction of leukocytes with these ECM components controls leukocyte retention and accumulation, proliferation, migration, differentiation, and activation as part of the inflammatory phase of lung disease. In addition, bronchial epithelial cells from asthmatic children co-cultured with human lung fibroblasts generate an ECM that is adherent for monocytes/macrophages. Macrophages are present in both early and late lung inflammation. Matrix metalloproteinase 10 (MMP10) is induced in alveolar macrophages with injury and infection and modulates macrophage phenotype and their ability to degrade collagenous ECM components. Collectively, studies outlined in this review highlight the importance of specific ECM components in the regulation of inflammatory events in lung disease. The widespread involvement of these ECM components in the pathogenesis of lung inflammation make them attractive candidates for therapeutic intervention.
authors.affiliation: Matrix Biology Program, Benaroya Research Institute at Virginia Mason, Seattle, WA, USA. Electronic address: twight@benaroyaresearch.org.
authors.forename: Thomas N
authors.initials: TN
authors.lastname: Wight
authors.affiliation: Department of Comparative Medicine, University of Washington, Seattle, WA, USA.
authors.forename: Charles W
authors.initials: CW
authors.lastname: Frevert
authors.affiliation: Center for Immunity and Immunotherapies, Seattle Children's Research Institute, and Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA.
authors.forename: Jason S
authors.initials: JS
authors.lastname: Debley
authors.affiliation: Center for Immunity and Immunotherapies, Seattle Children's Research Institute, and Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA.
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Reeves
authors.affiliation: Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
authors.forename: William C
authors.initials: WC
authors.lastname: Parks
authors.affiliation: Immunology Program, Benaroya Research Institute at Virginia Mason, Seattle, WA, USA.
authors.forename: Steven F
authors.initials: SF
authors.lastname: Ziegler
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002465:Cell Movement; D005109:Extracellular Matrix / Q000378:metabolism*; D006801:Humans; D006820:Hyaluronic Acid / Q000378:metabolism*; D007962:Leukocytes / Q000276:immunology*; D016676:Macrophages, Alveolar / Q000276:immunology*; D053506:Matrix Metalloproteinase 10 / Q000378:metabolism*; D058990:Molecular Targeted Therapy; D011014:Pneumonia / Q000276:immunology*; D053675:Versicans / Q000378:metabolism*
chemical_list: D053675:Versicans; D006820:Hyaluronic Acid; D053506:Matrix Metalloproteinase 10
keywords: Asthma; Extracellular matrix; Fibrosis; Hyaluronan; Immunity; Inflammation; Macrophage; Matrix metalloproteinase 10; Versican