title: The Role of Myeloid-Derived Suppressor Cells in Viral Infection.
abstract: Myeloid-derived suppressor cells (MDSCs) are heterogeneous immature myeloid cells that are well described as potent immune regulatory cells during human cancer and murine tumor models. Reports of MDSCs during viral infections remain limited, and their association with immunomodulation of viral diseases is still being defined. Here, we provide an overview of MDSCs or MDSC-like cells identified during viral infections, including murine viral models and human viral diseases. Understanding the similarities and/or differences of virally induced versus tumor-derived MDSCs will be important for designing future immunotherapeutic approaches.
authors.affiliation: 1 Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth , Lebanon , New Hampshire.
authors.forename: Megan A
authors.initials: MA
authors.lastname: O'Connor
authors.affiliation: 1 Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth , Lebanon , New Hampshire.
authors.forename: Jessica L
authors.initials: JL
authors.lastname: Rastad
authors.affiliation: 1 Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth , Lebanon , New Hampshire.|2 Norris Cotton Cancer Center , Geisel School of Medicine at Dartmouth, Lebanon , New Hampshire.
authors.forename: William R
authors.initials: WR
authors.lastname: Green
mesh_terms: D000818:Animals; D006801:Humans; D000072737:Myeloid-Derived Suppressor Cells / Q000276:immunology*; D014777:Virus Diseases / Q000276:immunology*
keywords: MDSCs; immunotherapeutic approaches; viral infections