title: Biodegradable Magnesium Screws Accelerate Fibrous Tissue Mineralization at the Tendon-Bone Insertion in Anterior Cruciate Ligament Reconstruction Model of Rabbit.
abstract: The incorporation of tendon graft into bone tunnel is one of the most challenging clinical issues in anterior cruciate ligament (ACL) reconstruction. As a biodegradable metal, Mg has appropriate mechanical strength and osteoinductive effects, thus may be a promising alternative to commercialized products used for graft fixation. Therefore, it was hypothesized that Mg based interference screws would promote tendon graft-bone junction healing when compared to Ti screws. Herein, we compared the effects of Mg and Ti screws on tendon graft healing in rabbits with ACL reconstruction via histological, HR-pQCT and mechanical analysis. The histological results indicated that Mg screws significantly improved the graft healing quality via promoting mineralization at the tendon graft enthesis. Besides, Mg screws significantly promoted bone formation in the peri-screw region at the early healing stage. Importantly, Mg screws exhibited excellent corrosion resistance and the degradation of Mg screws did not induce bone tunnel widening. In tensile testing, there were no significant differences in the load to failure, stress, stiffness and absorption energy between Mg and Ti groups due to the failure mode at the midsubstance. Our findings demonstrate that Mg screws can promote tendon graft healing after ACL reconstruction, implying a potential alternative to Ti screws for clinical applications.
authors.affiliation: Musculoskeletal Research Laboratory, Department of Orthopaedics &Traumatology, The Chinese University of Hong Kong, Hong Kong SAR, PR China.
authors.forename: Jiali
authors.initials: J
authors.lastname: Wang
authors.affiliation: Musculoskeletal Research Laboratory, Department of Orthopaedics &Traumatology, The Chinese University of Hong Kong, Hong Kong SAR, PR China.
authors.forename: Jiankun
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, China.
authors.forename: Weimin
authors.initials: W
authors.lastname: Fu
authors.affiliation: Center for Translational Medicine Research and Development, Institute of Biomedical and Health Engineering, Chinese Academy of Sciences, Shenzhen 518055, PR China.
authors.forename: Wenxiang
authors.initials: W
authors.lastname: Cheng
authors.affiliation: Musculoskeletal Research Laboratory, Department of Orthopaedics &Traumatology, The Chinese University of Hong Kong, Hong Kong SAR, PR China.
authors.forename: Kaiming
authors.initials: K
authors.lastname: Chan
authors.affiliation: Musculoskeletal Research Laboratory, Department of Orthopaedics &Traumatology, The Chinese University of Hong Kong, Hong Kong SAR, PR China.
authors.forename: Patrick Shu-Hang
authors.initials: PS
authors.lastname: Yung
authors.affiliation: Musculoskeletal Research Laboratory, Department of Orthopaedics &Traumatology, The Chinese University of Hong Kong, Hong Kong SAR, PR China.|Center for Translational Medicine Research and Development, Institute of Biomedical and Health Engineering, Chinese Academy of Sciences, Shenzhen 518055, PR China.
authors.forename: Ling
authors.initials: L
authors.lastname: Qin
mesh_terms: D000818:Animals; D016118:Anterior Cruciate Ligament / Q000254:growth & development / Q000503:physiopathology / Q000601:surgery*; D000070598:Anterior Cruciate Ligament Injuries / Q000503:physiopathology / Q000601:surgery*; D059549:Anterior Cruciate Ligament Reconstruction / Q000379:methods; D001672:Biocompatible Materials / Q000627:therapeutic use; D001863:Bone Screws; D006801:Humans; D008274:Magnesium / Q000627:therapeutic use*; D010012:Osteogenesis / Q000187:drug effects* / Q000502:physiology; D011817:Rabbits; D014025:Titanium / Q000627:therapeutic use; D014945:Wound Healing / Q000187:drug effects
chemical_list: D001672:Biocompatible Materials; D014025:Titanium; D008274:Magnesium