title: Assessment of the antimicrobial, antioxidant and cytotoxic activities of the wild edible mushroom Agaricus lanipes (F.H. Møller & Jul. Schäff.) Hlaváček.
abstract: The present investigation was undertaken to evaluate the antimicrobial and antioxidant activities of the wild edible mushroom Agaricus lanipes, and also to investigate its cytotoxicity and potential and possible apoptotic effect against the A549 lung cancer cell line in in vitro conditions. Total antioxidant capacity, total phenolic content, total oxidant status, total antioxidant status, lipid hydroperoxides, and total free -SH levels of A. lanipes were found to be 4.55 mg T/g, 14.6 mg GA equivalent/g, 3.10 mg H2O2equivalent/g, 2.25 mg H2O2equivalent/g, and 1.90 µmol/g, respectively. The methanolic extract of A. lanipes had relatively strong antimicrobial activity against seven tested microorganism strains. It also had high anti-proliferative potency and strong pro-apoptotic effects, and this mushroom used as a daily nutrient could be a source for new drug developments and treatment in cancer therapies, and could be a guide for studies in this area.
authors.affiliation: Department of Biology, Faculty of Science and Arts, Pamukkale University, P.O. BOX 20001, Denizli, Turkey. okaygusuz03@gmail.com.
authors.forename: Oğuzhan
authors.initials: O
authors.lastname: Kaygusuz
authors.affiliation: Denizli Vocational School of Technical Sciences, Pamukkale University, Denizli, Turkey.
authors.forename: Meruyert
authors.initials: M
authors.lastname: Kaygusuz
authors.affiliation: Department of Medical Biology, Faculty of Medicine, Pamukkale University, Denizli, Turkey.
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Dodurga
authors.affiliation: Department of Medical Biology, Faculty of Medicine, Pamukkale University, Denizli, Turkey.
authors.forename: Mücahit
authors.initials: M
authors.lastname: Seçme
authors.affiliation: Department of Food Engineering, Engineering Faculty, Pamukkale University, Denizli, Turkey.
authors.forename: Emine Nur
authors.initials: EN
authors.lastname: Herken
authors.affiliation: Department of Biology, Faculty of Science and Arts, Pamukkale University, P.O. BOX 20001, Denizli, Turkey.
authors.forename: Kutret
authors.initials: K
authors.lastname: Gezer
keywords: Agaricus lanipes; Antimicrobial; Antioxidant; Cytotoxic effect