title: Antiobesity Effects of Hydroethanolic Extract ofJacaranda decurrensLeaves.
abstract: Obesity is a worldwide epidemic that reduces life expectancy; therefore, the search for new alternative and effective treatments is ongoing. The aim of the present investigation was to identify the chemical compounds in the hydroethanolic extract of leaves ofJacaranda decurrenssubsp.symmetrifoliolataand to evaluate their toxicity and antiobesity effects. High-performance liquid chromatography was used to identify the chemical constituents, and acute toxicity was evaluated in rats treated with doses of 2 and 5 g·kg-1body mass. The antiobesity effect was determined in rats with hypercaloric diet-induced obesity. Our results revealed the presence of compounds, such as jacaric, ursolic, and oleic acids, as well as luteolin, quercetin, and kaempferol, in the extract. The acute toxicity tests revealed that rats treated with elevated doses of the extract showed no signs of toxicity. The extract induced reduction in total body mass and the white adipose tissue depots. The obese rats treated with the extract showed an increased fluid intake and feces excretion while their serum total cholesterol and triglyceride levels decreased compared to those in the controls, without any hematological changes. Taken together, the results showed that the constituents ofJ. decurrensextracts included phenolic compounds and exhibited antiobesity effects with no toxicity.
authors.affiliation: School of Environmental and Biological Science, Federal University of Grande Dourados, Rodovia Dourados Itahum, Km 12, 79804-970 Dourados, MS, Brazil.
authors.forename: Kátia Avila
authors.identifier: 0000-0002-0451-5189
authors.initials: KA
authors.lastname: Antunes
authors.affiliation: School of Environmental and Biological Science, Federal University of Grande Dourados, Rodovia Dourados Itahum, Km 12, 79804-970 Dourados, MS, Brazil.
authors.forename: Débora da Silva
authors.initials: DD
authors.lastname: Baldivia
authors.affiliation: School of Environmental and Biological Science, Federal University of Grande Dourados, Rodovia Dourados Itahum, Km 12, 79804-970 Dourados, MS, Brazil.
authors.forename: Paola Dos Santos
authors.identifier: 0000-0003-1019-1202
authors.initials: PD
authors.lastname: da Rocha
authors.affiliation: School of Environmental and Biological Science, Federal University of Grande Dourados, Rodovia Dourados Itahum, Km 12, 79804-970 Dourados, MS, Brazil.
authors.forename: Junior Cesar
authors.initials: JC
authors.lastname: Casagrande
authors.affiliation: Faculty of Food Engineering, Federal University of Grande Dourados, Rodovia Dourados Itahum, Km 12, 79804-970 Dourados, MS, Brazil.
authors.forename: Eliana Janet Sanjinez
authors.initials: EJ
authors.lastname: Argandoña
authors.affiliation: Agricultural Sciences, Federal University of Grande Dourados, Rodovia Dourados Itahum, Km 12, 79804-970 Dourados, MS, Brazil.
authors.forename: Maria do Carmo
authors.initials: MD
authors.lastname: Vieira
authors.affiliation: Course of Chemistry, State University of Mato Grosso do Sul, Rodovia Dourados Itahum, Km 12, 79804-970 Dourados, MS, Brazil.
authors.forename: Cláudia Andrea Lima
authors.initials: CA
authors.lastname: Cardoso
authors.affiliation: School of Environmental and Biological Science, Federal University of Grande Dourados, Rodovia Dourados Itahum, Km 12, 79804-970 Dourados, MS, Brazil.
authors.forename: Edson Lucas
authors.identifier: 0000-0002-6557-7914
authors.initials: EL
authors.lastname: Dos Santos
authors.affiliation: School of Environmental and Biological Science, Federal University of Grande Dourados, Rodovia Dourados Itahum, Km 12, 79804-970 Dourados, MS, Brazil.
authors.forename: Kely
authors.identifier: 0000-0001-5764-2125
authors.initials: K
authors.lastname: de Picoli Souza