title: A Regenerative Cardiac Patch Formed by Spray Painting of Biomaterials onto the Heart.
abstract: Layering a regenerative polymer scaffold on the surface of the heart, termed as a cardiac patch, has been proven to be effective in preserving cardiac function after myocardial infarction (MI). However, the placement of such a patch on the heart usually needs open-chest surgery, which is traumatic, therefore prevents the translation of this strategy into the clinic. We sought to device a way to apply a cardiac patch by spray painting in situ polymerizable biomaterials onto the heart with a minimally invasive procedure. To prove the concept, we used platelet fibrin gel as the "paint" material in a mouse model of MI. The use of the spraying system allowed for placement of a uniform cardiac patch on the heart in a mini-invasive manner without the need for sutures or glue. The spray treatment promoted cardiac repair and attenuated cardiac dysfunction after MI.
authors.affiliation: 1 Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China .|2 Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, North Carolina State University , Raleigh, North Carolina.|3 Department of Molecular Biomedical Sciences, Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University , Raleigh, North Carolina.
authors.forename: Junnan
authors.initials: J
authors.lastname: Tang
authors.affiliation: 2 Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, North Carolina State University , Raleigh, North Carolina.|3 Department of Molecular Biomedical Sciences, Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University , Raleigh, North Carolina.
authors.forename: Adam
authors.initials: A
authors.lastname: Vandergriff
authors.affiliation: 4 The Cyrus Tang Hematology Center, Soochow University , Suzhou, China .
authors.forename: Zegen
authors.initials: Z
authors.lastname: Wang
authors.affiliation: 2 Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, North Carolina State University , Raleigh, North Carolina.|3 Department of Molecular Biomedical Sciences, Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University , Raleigh, North Carolina.
authors.forename: Michael Taylor
authors.initials: MT
authors.lastname: Hensley
authors.affiliation: 2 Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, North Carolina State University , Raleigh, North Carolina.|3 Department of Molecular Biomedical Sciences, Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University , Raleigh, North Carolina.
authors.forename: Jhon
authors.initials: J
authors.lastname: Cores
authors.affiliation: 2 Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, North Carolina State University , Raleigh, North Carolina.|3 Department of Molecular Biomedical Sciences, Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University , Raleigh, North Carolina.
authors.forename: Tyler A
authors.initials: TA
authors.lastname: Allen
authors.affiliation: 2 Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, North Carolina State University , Raleigh, North Carolina.|3 Department of Molecular Biomedical Sciences, Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University , Raleigh, North Carolina.
authors.forename: Phuong-Uyen
authors.initials: PU
authors.lastname: Dinh
authors.affiliation: 1 Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China .
authors.forename: Jinying
authors.initials: J
authors.lastname: Zhang
authors.affiliation: 5 Division of Cardiothoracic Surgery, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina.
authors.forename: Thomas George
authors.initials: TG
authors.lastname: Caranasos
authors.affiliation: 2 Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, North Carolina State University , Raleigh, North Carolina.|3 Department of Molecular Biomedical Sciences, Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University , Raleigh, North Carolina.|4 The Cyrus Tang Hematology Center, Soochow University , Suzhou, China .|6 Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina.
authors.forename: Ke
authors.initials: K
authors.lastname: Cheng
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D001792:Blood Platelets / Q000378:metabolism*; D005337:Fibrin / Q000378:metabolism*; D006321:Heart / Q000502:physiology*; D008297:Male; D051379:Mice; D009203:Myocardial Infarction / Q000473:pathology / Q000628:therapy*; D032383:Myocytes, Cardiac / Q000166:cytology*; D010151:Paintings; D051381:Rats; D017207:Rats, Sprague-Dawley; D012038:Regeneration / Q000502:physiology*
chemical_list: D001672:Biocompatible Materials; D005337:Fibrin
keywords: cardiac patch; myocardial infarction; platelet fibrin gel; regeneration