title: Modeling Human Cancers in Drosophila.
abstract: Cancer is a complex disease that affects multiple organs. Whole-body animal models provide important insights into oncology that can lead to clinical impact. Here, we review novel concepts that Drosophila studies have established for cancer biology, drug discovery, and patient therapy. Genetic studies using Drosophila have explored the roles of oncogenes and tumor-suppressor genes that when dysregulated promote cancer formation, making Drosophila a useful model to study multiple aspects of transformation. Not limited to mechanism analyses, Drosophila has recently been showing its value in facilitating drug development. Flies offer rapid, efficient platforms by which novel classes of drugs can be identified as candidate anticancer leads. Further, we discuss the use of Drosophila as a platform to develop therapies for individual patients by modeling the tumor's genetic complexity. Drosophila provides both a classical and a novel tool to identify new therapeutics, complementing other more traditional cancer tools.
authors.affiliation: Icahn School of Medicine at Mount Sinai, New York, NY, United States; Kyoto University Graduate School of Medicine, Kyoto, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Sonoshita
authors.affiliation: Icahn School of Medicine at Mount Sinai, New York, NY, United States. Electronic address: ross.cagan@mssm.edu.
authors.forename: R L
authors.initials: RL
authors.lastname: Cagan
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004330:Drosophila / Q000502:physiology*; D055808:Drug Discovery; D004353:Drug Evaluation, Preclinical; D006801:Humans; D009369:Neoplasms / Q000473:pathology*; D059016:Tumor Microenvironment
keywords: Cancer; Drosophila; Drug screening; Genetic screening; Invasion; Metastasis; Oncogene; Personalized medicine; Polypharmacology; Tumor-suppressor gene