title: Helicobacter pylori: A Paradigm Pathogen for Subverting Host Cell Signal Transmission.
abstract: Helicobacter pylori colonizes the gastric mucosa in the human stomach and represents a major risk factor for peptic ulcer disease and gastric cancer. Here, we summarize our current knowledge of the complex impact of H. pylori on manipulating host signalling networks, that is, by the cag pathogenicity island (cagPAI)-encoded type IV secretion system (T4SS). We show that H. pylori infections reflect a paradigm for interspecies contact-dependent molecular communication, which includes the disruption of cell-cell junctions and cytoskeletal rearrangements, as well as proinflammatory, cell cycle-related, proliferative, antiapoptotic, and DNA damage responses. The contribution of these altered signalling cascades to disease outcome is discussed.
authors.affiliation: Otto von Guericke University, Institute of Experimental Internal Medicine, Medical Faculty, Leipziger Str. 44, 39120 Magdeburg, Germany. Electronic address: Naumann@med.ovgu.de.
authors.forename: Michael
authors.initials: M
authors.lastname: Naumann
authors.affiliation: Otto von Guericke University, Institute of Experimental Internal Medicine, Medical Faculty, Leipziger Str. 44, 39120 Magdeburg, Germany.
authors.forename: Olga
authors.initials: O
authors.lastname: Sokolova
authors.affiliation: Friedrich Alexander University Erlangen-Nuremberg, Department Biology, Division of Microbiology, Staudtstr. 5, 91058 Erlangen, Germany.
authors.forename: Nicole
authors.initials: N
authors.lastname: Tegtmeyer
authors.affiliation: Friedrich Alexander University Erlangen-Nuremberg, Department Biology, Division of Microbiology, Staudtstr. 5, 91058 Erlangen, Germany.
authors.forename: Steffen
authors.initials: S
authors.lastname: Backert
mesh_terms: D001422:Bacterial Adhesion / Q000502:physiology*; D004249:DNA Damage / Q000235:genetics; D004260:DNA Repair / Q000235:genetics; D005753:Gastric Mucosa / Q000382:microbiology / Q000473:pathology*; D016481:Helicobacter Infections / Q000382:microbiology / Q000473:pathology*; D016480:Helicobacter pylori / Q000235:genetics / Q000472:pathogenicity*; D054884:Host-Pathogen Interactions / Q000502:physiology; D006801:Humans; D007365:Intercellular Junctions / Q000382:microbiology; D010437:Peptic Ulcer / Q000382:microbiology; D015398:Signal Transduction / Q000502:physiology; D013270:Stomach / Q000382:microbiology / Q000473:pathology*; D013274:Stomach Neoplasms / Q000382:microbiology; D000069319:Type IV Secretion Systems / Q000378:metabolism*; D037521:Virulence Factors / Q000235:genetics
chemical_list: D000069319:Type IV Secretion Systems; D037521:Virulence Factors
keywords: T4SS; gastric cancer; inflammation; pathogen; signalling pathways