title: A mitochondria-targeting fluorescent probe for the selective detection of glutathione in living cells.
abstract: We report a fluorescent probe for the selective detection of mitochondrial glutathione (GSH). The probe, containing triphenylphosphine as a mitochondrial targeting group, exhibited ratiometric and selective detection of GSH over Cys/Hcy. The probe was used for imaging mitochondrial GSH in living HeLa cells.
authors.affiliation: School of Chemistry and biological Engineering, University of Science and Technology Beijing, Beijing 100083, P. R. China. yxyang@ustb.edu.cn.
authors.forename: Xue-Liang
authors.initials: XL
authors.lastname: Liu
authors.affiliation: Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, P. R. China. niuly@bnu.edu.cn qzyang@bnu.edu.cn.
authors.forename: Li-Ya
authors.initials: LY
authors.lastname: Niu
authors.affiliation: Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China.
authors.forename: Yu-Zhe
authors.initials: YZ
authors.lastname: Chen
authors.affiliation: Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China.
authors.forename: Mei-Ling
authors.identifier: http://orcid.org/0000-0002-9459-799X
authors.initials: ML
authors.lastname: Zheng
authors.affiliation: School of Chemistry and biological Engineering, University of Science and Technology Beijing, Beijing 100083, P. R. China. yxyang@ustb.edu.cn.
authors.forename: Yunxu
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, P. R. China. niuly@bnu.edu.cn qzyang@bnu.edu.cn.
authors.forename: Qing-Zheng
authors.identifier: http://orcid.org/0000-0002-9131-4907
authors.initials: QZ
authors.lastname: Yang
mesh_terms: D005456:Fluorescent Dyes / Q000032:analysis / Q000138:chemical synthesis / Q000737:chemistry*; D005978:Glutathione / Q000032:analysis*; D006367:HeLa Cells; D006801:Humans; D008928:Mitochondria / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D005456:Fluorescent Dyes; D005978:Glutathione