title: Association between PPAP2B gene polymorphisms and coronary heart disease susceptibility in Chinese Han males and females.
abstract: Little is known about gender-related differences in the association between PPAP2B single nucleotide polymorphisms (SNPs) and coronary heart disease (CHD) in Chinese Han males and females. We therefore conducted a case-control study with 456 cases and 685 healthy controls divided into male and female subgroups. Five PPAP2B polymorphisms (SNPs) were selected and genotyped using Sequenom Mass-ARRAY technology. Odds ratios (OR) and 95% confidence intervals (CIs) were calculated using unconditional logistic regression adjusting for age and gender. Allelic model analysis revealed that for PPAP2B rs1759752, allele frequency distributions differed between cases and controls in the male subgroup (p = 0.015, OR: 1.401, 95%CI: 1.066-1.481). Genetic model analysis revealed that in the male subgroup, rs1759752 was associated with increased CHD risk in the dominant model (p = 0.035) and overdominant model (p = 0.045). In the female subgroup, rs12566304 was associated with a decreased CHD risk in the codominant model (p = 0.038) and overdominant model (p = 0.031). Additionally, the "GC" haplotypes of rs1759752 and rs1930760 were protective against CHD in males. These observations shed new light on gender-related differences in the association between PPAP2B gene polymorphisms and CHD susceptibility in the Chinese Han population.
authors.affiliation: Department of Cardiology, The Seventh People's Hospital, Zhengzhou, Henan, 450016, China.
authors.forename: Yu-Xiao
authors.initials: YX
authors.lastname: Sun
authors.affiliation: Department of Cardiology, Henan Provincial People's Hospital, Zhengzhou, 450000, China.
authors.forename: Chuan-Yu
authors.initials: CY
authors.lastname: Gao
authors.affiliation: Department of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Fu
authors.affiliation: Department of Cardiology, The Seventh People's Hospital, Zhengzhou, Henan, 450016, China.
authors.forename: Jun-Ge
authors.initials: JG
authors.lastname: Jia
authors.affiliation: Department of Cardiology, The Seventh People's Hospital, Zhengzhou, Henan, 450016, China.
authors.forename: Yu-Jie
authors.initials: YJ
authors.lastname: Zhao
authors.affiliation: Department of Cardiology, The Seventh People's Hospital, Zhengzhou, Henan, 450016, China.
authors.forename: Lian-Dong
authors.initials: LD
authors.lastname: Li
authors.affiliation: Department of Cardiology, The Seventh People's Hospital, Zhengzhou, Henan, 450016, China.
authors.forename: Hong-Zhi
authors.initials: HZ
authors.lastname: Dui
authors.affiliation: Department of Cardiology, The Seventh People's Hospital, Zhengzhou, Henan, 450016, China.
authors.forename: Xing-Yu
authors.initials: XY
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, The Seventh People's Hospital, Zhengzhou, Henan, 450016, China.
authors.forename: Zhi-Ying
authors.initials: ZY
authors.lastname: Li
authors.affiliation: Department of Cardiology, The Seventh People's Hospital, Zhengzhou, Henan, 450016, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Lei
authors.affiliation: Department of Cardiology, The Seventh People's Hospital, Zhengzhou, Henan, 450016, China.
authors.forename: Wei-Feng
authors.initials: WF
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, The Seventh People's Hospital, Zhengzhou, Henan, 450016, China.
authors.forename: Yi-Qiang
authors.initials: YQ
authors.lastname: Yuan
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China; D003327:Coronary Disease / Q000201:enzymology / Q000208:ethnology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010711:Phosphatidate Phosphatase / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D012737:Sex Factors
chemical_list: C521833:PLPP3 protein, human; D010711:Phosphatidate Phosphatase
keywords: Chinese Han population; PPAP2B; case-control study; coronary heart disease (CHD); single nucleotide polymorphisms (SNPs)