title: Histological evaluation of capsules formed by silicon implants coated with polyurethane foam and with a textured surface in rats.
abstract: To assess the capsules formed by silicone implants coated with polyurethane foam and with a textured surface.
  Sixty-four Wistar albinus rats were divided into two groups of 32 each using polyurethane foam and textured surface. The capsules around the implants were analyzed for 30, 50, 70 and 90 days. Were analyzed the following parameters: foreign body reaction, granulation tissue, presence of myofibroblasts, neoangiogenesis, presence of synovial metaplasia, capsular thickness, total area and collagen percentage of type I and III, in capsules formed around silicone implants in both groups.
  The foreign body reaction was only present in the four polyurethane subgroups. The formation of granulation tissue and the presence of myofibroblasts were higher in the four polyurethane subgroups. Regarding to neoangiogenesis and synovial metaplasia, there was no statistical difference between the groups. Polyurethane group presented (all subgroups) a greater capsule thickness, a smaller total area and collagen percentage of type I and a higher percentage area of type III, with statistical difference.
  The use of polyurethane-coated implants should be stimulated by the long-term results in a more stable capsule and a lower incidence of capsular contracture, despite developing a more intense and delayed inflammatory reaction in relation to implants with textured surface.
authors.affiliation: Fellow Master degree, Postgraduate Program in Principles of Surgery, Faculdade Evangélica do Paraná (FEPAR), Evangelic University Hospital (HUEC) and Institute for Medical Research (IPEM), Curitiba-PR, Brazil. Assistant Professor, General Surgery, Universidade Estadual de Ponta Grossa (UEPG), PR, Brazil. Conception, design, intellectual and scientific content of the study; technical procedures; statistical analysis.
authors.forename: Eduardo Nascimento
authors.initials: EN
authors.lastname: Silva
authors.affiliation: Associate Professor, Postgraduate Program in Principles of Surgery, FEPAR, Evangelic University Hospital (HUEC) and Institute for Medical Research (IPEM), Curitiba-PR, Brazil. Scientific and intellectual content of the study, interpretation of data, critical revision, final approval.
authors.forename: Jurandir Marcondes
authors.initials: JM
authors.lastname: Ribas-Filho
authors.affiliation: Associate Professor, Postgraduate Program in Principles of Surgery, FEPAR, Evangelic University Hospital (HUEC) and Institute for Medical Research (IPEM), Curitiba-PR, Brazil. Scientific and intellectual content of the study, interpretation of data, critical revision.
authors.forename: Nicolau Gregori
authors.initials: NG
authors.lastname: Czeczko
authors.affiliation: Fellow PhD degree, Postgraduate Program in Principles of Surgery, FEPAR, Evangelic University Hospital (HUEC) and Institute for Medical Research (IPEM), Curitiba-PR, Brazil. Conception, design, intellectual and scientific content of the study.
authors.forename: Jan Pawel Andrade
authors.initials: JP
authors.lastname: Pachnicki
authors.affiliation: MSc, Clinical Surgery, Universidade Federal do Paraná (UFPR), Curitiba-PR, Brazil. Assistant Professor, Anatomical Pathology, UEPG, Ponta Grossa-PR. Head, Department of Anatomical Pathology, Santa Casa de Misericórdia, Ponta Grossa-PR, Brazil. Scientific and intellectual content of the study, interpretation of data, critical revision.
authors.forename: Mário Rodrigues Montemor
authors.initials: MR
authors.lastname: Netto
authors.affiliation: DVM, Assistant Professor, Faculty of Medicine, UEPG, Ponta Grossa-PR, Brazil. Scientific and intellectual content of the study, interpretation of data, critical revision.
authors.forename: Leandro Cavalcante
authors.initials: LC
authors.lastname: Lipinski
authors.affiliation: PhD, School of Medicine, Pontifícia Universidade Católica do Paraná (PUCPR), Curitiba-PR, Brazil. Interpretation of data, histopathological examinations.
authors.forename: Lucia de
authors.initials: L
authors.lastname: Noronha
authors.affiliation: MD, Faculty of Medicine, UEPG, Ponta Grossa-PR, Brazil. Acquisition of data, technical procedures, manuscript preparation.
authors.forename: Joelmir
authors.initials: J
authors.lastname: Colman
authors.affiliation: Graduate student, FEPAR, Evangelic University Hospital (HUEC) and Institute for Medical Research (IPEM), Curitiba-PR, Brazil. Acquisition of data, technical procedures.
authors.forename: João Otavio
authors.initials: JO
authors.lastname: Zeni
authors.affiliation: Graduate student, FEPAR, Evangelic University Hospital (HUEC) and Institute for Medical Research (IPEM), Curitiba-PR, Brazil. Acquisition of data, technical procedures.
authors.forename: Caroline Aragão de
authors.initials: CA
authors.lastname: Carvalho
mesh_terms: D000818:Animals; D019928:Breast Implantation / Q000379:methods; D018427:Breast Implants / Q000009:adverse effects*; D020099:Coated Materials, Biocompatible; D024042:Collagen Type I / Q000032:analysis; D024061:Collagen Type III / Q000032:analysis; D005260:Female; D005549:Foreign-Body Reaction / Q000473:pathology*; D057910:Implant Capsular Contracture / Q000473:pathology*; D011140:Polyurethanes / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D020034:Silicone Gels / Q000008:administration & dosage*; D013499:Surface Properties
chemical_list: D020099:Coated Materials, Biocompatible; D024042:Collagen Type I; D024061:Collagen Type III; D011140:Polyurethanes; D020034:Silicone Gels; C028279:polyurethane foam