title: Antibacterial Properties of Calcium Fluoride-Based Composite Materials:In VitroStudy.
abstract: The aim of the study was to evaluate antibacterial activity of composite materials modified with calcium fluoride against cariogenic bacteriaS. mutansandL. acidophilus. One commercially available conventional light-curing composite material containing fluoride ions (F2) and two commercially available flowable light-curing composite materials (Flow Art and X-Flow) modified with 1.5, 2.5, and 5.0 wt% anhydrous calcium fluoride addition were used in the study. Composite material samples were incubated in 0.95% NaCl at 35°C for 3 days; then dilution series ofS. mutansandL. acidophilusstrains were made from the eluates. Bacteria dilutions were cultivated on media afterwards. Colony-forming unit per 1 mL of solution (CFU/mL) was calculated. Composite materials modified with calcium fluoride highly reduced (p< 0.001) bacteria growth compared to commercially available composite materials containing fluoride compounds. The greatest reduction in bacteria growth was observed for composite materials modified with 1.5% wt. CaF2. All three tested composite materials showed statistically greater antibacterial activity againstL. acidophilusthan againstS. mutans.
authors.affiliation: Department of General Dentistry, Medical University of Lodz, Lodz, Poland.
authors.forename: Monika
authors.identifier: 0000-0002-6110-4298
authors.initials: M
authors.lastname: Łukomska-Szymańska
authors.affiliation: Department of Microbiology and Laboratory Medical Immunology, Medical University of Lodz, Lodz, Poland.
authors.forename: Beata
authors.initials: B
authors.lastname: Zarzycka
authors.affiliation: Department of Microbiology and Laboratory Medical Immunology, Medical University of Lodz, Lodz, Poland.
authors.forename: Janina
authors.initials: J
authors.lastname: Grzegorczyk
authors.affiliation: Department of Conservative Dentistry, Medical University of Lodz, Lodz, Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Sokołowski
authors.affiliation: Department of General Dentistry, Medical University of Lodz, Lodz, Poland.
authors.forename: Konrad
authors.initials: K
authors.lastname: Półtorak
authors.affiliation: Department of General Dentistry, Medical University of Lodz, Lodz, Poland.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Sokołowski
authors.affiliation: Department of General Dentistry, Medical University of Lodz, Lodz, Poland.
authors.forename: Barbara
authors.identifier: 0000-0003-2348-8515
authors.initials: B
authors.lastname: Łapińska
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002124:Calcium Fluoride / Q000627:therapeutic use*; D055117:Curing Lights, Dental / Q000382:microbiology; D003764:Dental Materials / Q000627:therapeutic use; D005459:Fluorides / Q000627:therapeutic use; D006801:Humans; D019279:Resin Cements / Q000627:therapeutic use; D013295:Streptococcus mutans / Q000187:drug effects* / Q000472:pathogenicity
chemical_list: D000900:Anti-Bacterial Agents; D003764:Dental Materials; D019279:Resin Cements; D002124:Calcium Fluoride; D005459:Fluorides