title: Nutrition Status Predicts Severity of Vascular Calcification in Non-Dialyzed Chronic Kidney Disease.
abstract: Vascular calcification is a major complication in chronic kidney disease (CKD) that increases the risk of adverse clinical outcomes. Geriatric nutritional risk index (GNRI) is a simple nutritional assessment tool that predicts poor prognosis in elderly subjects. The purpose of the present study was to evaluate the correlation between GNRI and severity of vascular calcification in non-dialyzed CKD patients.
  
  
  
  We enrolled 323 asymptomatic CKD patients. To evaluate abdominal aortic calcification (AAC), we used aortic calcification index (ACI) determined on non-contrast computed tomography. The patients were divided into three groups according to GNRI tertile. Median ACI significantly decreased with increasing GNRI tertile (15.5%, 13.6%, and 7.9%, respectively; P=0.001). On multivariate regression analysis GNRI was significantly correlated with ACI (β=-0.15, P=0.009). We also investigated the combination of GNRI and C-reactive-protein (CRP) for predicting the severity of AAC. Low GNRI and high CRP were significantly associated with severe AAC, compared with high GNRI and low CRP (OR, 4.07; P=0.004).
  
  
  
  GNRI was significantly associated with AAC in non-dialyzed CKD patients.
authors.affiliation: Department of Cardiology, Nagoya University Graduate School of Medicine.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Harada
authors.forename: Susumu
authors.initials: S
authors.lastname: Suzuki
authors.forename: Hideki
authors.initials: H
authors.lastname: Ishii
authors.forename: Kenshi
authors.initials: K
authors.lastname: Hirayama
authors.forename: Toshijiro
authors.initials: T
authors.lastname: Aoki
authors.forename: Yohei
authors.initials: Y
authors.lastname: Shibata
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Negishi
authors.forename: Takuya
authors.initials: T
authors.lastname: Sumi
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Kawashima
authors.forename: Ayako
authors.initials: A
authors.lastname: Kunimura
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Tatami
authors.forename: Toshiki
authors.initials: T
authors.lastname: Kawamiya
authors.forename: Dai
authors.initials: D
authors.lastname: Yamamoto
authors.forename: Ryota
authors.initials: R
authors.lastname: Morimoto
authors.forename: Yoshinari
authors.initials: Y
authors.lastname: Yasuda
authors.forename: Toyoaki
authors.initials: T
authors.lastname: Murohara
mesh_terms: D000368:Aged; D001012:Aorta, Abdominal / Q000000981:diagnostic imaging*; D001027:Aortography; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D051436:Renal Insufficiency, Chronic / Q000097:blood / Q000150:complications / Q000000981:diagnostic imaging; D012720:Severity of Illness Index; D061205:Vascular Calcification / Q000097:blood / Q000000981:diagnostic imaging / Q000209:etiology
chemical_list: D002097:C-Reactive Protein