title: Diabetes Mellitus and Bone Metabolism.
abstract: Diabetes mellitus and bone metabolism affect mesenchymal tissues and have numerous epidemiological and pathophysiological associations in common. Diabetes mellitus affects bone metabolism and increases fracture risk. The pathophysiological mechanims how type 1 and type 2 diabetes impair bone metabolism and bone strength may differ which is outlined in this review. Direct metabolic effects in additon to centrally controlled endocrine loops exert suppressive effects on bone formation and may also stimulate bone Resorption. Decreased bone formation in combination with increased bone resorption strongly increases fracture risk.
authors.affiliation: Medizinische Universitätsklinik Heidelberg, Abteilung Innere Medizin I und Klinische Chemie, INF, Heidelberg.
authors.forename: Christian
authors.initials: C
authors.lastname: Kasperk
authors.affiliation: Department of Endocrinology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Rumänien.
authors.forename: Carmen
authors.initials: C
authors.lastname: Georgescu
authors.affiliation: Medizinische Universitätsklinik Heidelberg, Abteilung Innere Medizin I und Klinische Chemie, INF, Heidelberg.
authors.forename: Peter
authors.initials: P
authors.lastname: Nawroth
mesh_terms: D000818:Animals; D015519:Bone Density / Q000502:physiology; D001862:Bone Resorption / Q000235:genetics / Q000378:metabolism; D001842:Bone and Bones / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D010012:Osteogenesis / Q000502:physiology