title: Bioactive diarylheptanoids and stilbenes from the rhizomes of Dioscorea septemloba Thunb.
abstract: The 70% ethanol extract of Dioscorea septemloba rhizomes was subjected to chromatographic columns including silica gel, ODS, D101 resin, Sephadex LH-20 and HPLC, to yield three new diarylheptanoids (1-3) and two novel stilbenes (4 and 5), together with six known ones (6-11). Their structures were elucidated on the basis of extensive 1D NMR (1H and13C), 2D NMR (COSY, HSQC, HMBC, NOESY), IR, and MS spectroscopic data analyses. Moreover, the in vitro bioactivity screening experiment suggested that compounds 6-8 and 10 could significantly increase the glucose consumption in differentiated L6 myotubes, and that 2, 9-11 displayed triglyceride inhibitory effects in HepG2 cells.
authors.affiliation: Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China; Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China.
authors.forename: Jingya
authors.initials: J
authors.lastname: Ruan
authors.affiliation: Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.affiliation: Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China.
authors.forename: Liping
authors.initials: L
authors.lastname: Chao
authors.affiliation: Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China.
authors.forename: Wenzhong
authors.initials: W
authors.lastname: Shi
authors.affiliation: Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China.
authors.forename: Haiyang
authors.initials: H
authors.lastname: Yu
authors.affiliation: Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China; Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China.
authors.forename: Xiumei
authors.initials: X
authors.lastname: Gao
authors.affiliation: Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China; Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China. Electronic address: wangtao@tjutcm.edu.cn.
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
mesh_terms: D000818:Animals; D036381:Diarylheptanoids / Q000737:chemistry* / Q000302:isolation & purification; D027742:Dioscorea / Q000737:chemistry*; D005947:Glucose / Q000378:metabolism; D056945:Hep G2 Cells; D006801:Humans; D015394:Molecular Structure; D032446:Myoblasts / Q000187:drug effects / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry; D051381:Rats; D027343:Rhizome / Q000737:chemistry; D013267:Stilbenes / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D036381:Diarylheptanoids; D010936:Plant Extracts; D013267:Stilbenes; D005947:Glucose
keywords: Diarylheptanoids; Dioscorea septemloba Thunb; Glucose consumption; HepG2 cells; L6 cells; Stilbenes; Triglyceride accumulation