title: Familial Hepatitis E Outbreak Linked to Wild Boar Meat Consumption.
abstract: An HIV-infected patient was diagnosed with acute hepatitis E infection in our hospital. An epidemiological inquiry was performed to collect demographic, food and animal exposure variables in order to identify the potential route of transmission. The patient reported that his family traditionally hunted wild boar for food. All family members were analysed for hepatitis E virus infection. Additionally, route of transmission by wild boar meat consumption and prevalence of HEV infection among wild boar from the same hunting area were investigated. In all-family members (n = 8), HEV-RNA was amplified. Two wild boar meat slices consumed was analysed, showing the presence of HEV. The virus isolated was consistent with genotype 3, revealing 100% homology between family members and meat. Additionally, we tested nine wild boar hunted in the same hunting area. All of them were RNA-HEV positive, isolating the same HEV genotype 3 viral strain. We demonstrated by phylogenetic analysis zoonotic transmission of HEV by wild boar meat consumption. The prevalence of HEV infection among wild boar found in our study suggests that this species is an important route of transmission to human.
authors.affiliation: Infectious Diseases Unit, Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Hospital Universitario Reina Sofía de Córdoba, Universidad de Córdoba, Cordoba, Spain.
authors.forename: A
authors.identifier: 0000-0002-5813-6889
authors.initials: A
authors.lastname: Rivero-Juarez
authors.affiliation: Infectious Diseases Unit, Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Hospital Universitario Reina Sofía de Córdoba, Universidad de Córdoba, Cordoba, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Frias
authors.affiliation: Infectious Diseases Unit, Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Hospital Universitario Reina Sofía de Córdoba, Universidad de Córdoba, Cordoba, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Martinez-Peinado
authors.affiliation: Sabio, Instituto de Investigación en Recursos Cinegéticos (CSIC-UCLM-JCCM), Ciudad Real, Spain.
authors.forename: M A
authors.initials: MA
authors.lastname: Risalde
authors.affiliation: Infectious Diseases Unit, Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Hospital Universitario Reina Sofía de Córdoba, Universidad de Córdoba, Cordoba, Spain.
authors.forename: D
authors.initials: D
authors.lastname: Rodriguez-Cano
authors.affiliation: Infectious Diseases Unit, Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Hospital Universitario Reina Sofía de Córdoba, Universidad de Córdoba, Cordoba, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Camacho
authors.affiliation: Animal Health Department, Veterinary Science College, Universidad de Córdoba, Cordoba, Spain.
authors.forename: I
authors.initials: I
authors.lastname: García-Bocanegra
authors.affiliation: Infectious Diseases Unit, Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Hospital Universitario Reina Sofía de Córdoba, Universidad de Córdoba, Cordoba, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Cuenca-Lopez
authors.affiliation: Animal Pathology Department, Veterinary Science College, Universidad de Córdoba, Cordoba, Spain.
authors.forename: J C
authors.initials: JC
authors.lastname: Gomez-Villamandos
authors.affiliation: Infectious Diseases Unit, Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Hospital Universitario Reina Sofía de Córdoba, Universidad de Córdoba, Cordoba, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Rivero
mesh_terms: D000818:Animals; D004196:Disease Outbreaks; D005516:Food Microbiology; D005838:Genotype; D016751:Hepatitis E / Q000209:etiology / Q000635:transmission / Q000821:virology; D016752:Hepatitis E virus / Q000235:genetics / Q000302:isolation & purification; D015658:HIV Infections / Q000150:complications; D010802:Phylogeny; D012367:RNA, Viral / Q000302:isolation & purification; D013030:Spain; D034421:Sus scrofa; D015047:Zoonoses / Q000635:transmission / Q000821:virology; D006801:Humans; D000080305:Pork Meat / Q000821:virology
chemical_list: D012367:RNA, Viral
keywords: HIV; Hepatitis E; foodborne; genotype 3; prevalence; veterinary; wild boar