title: Clinical application of quantitative computed tomography in osteogenesis imperfecta-suspected cat.
abstract: One-year-old male Persian cat presented with multiple fractures and no known traumatic history. Marked decrease of bone radiopacity and thin cortices of all long bones were identified on radiography. Tentative diagnosis was osteogenesis imperfecta, a congenital disorder characterized by fragile bone. To determine bone mineral density (BMD), quantitative computed tomography (QCT) was performed. The QCT results revealed a mean trabecular BMD of vertebral bodies of 149.9 ± 86.5 mg/cm3. After bisphosphonate therapy, BMD of the same site increased significantly (218.5 ± 117.1 mg/cm3,p＜ 0.05). QCT was a useful diagnostic tool to diagnose osteopenia and quantify response to medical treatment.
authors.affiliation: Irion Animal Hospital, Seoul 06015, Korea.|College of Veterinary Medicine and the Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Korea.
authors.forename: Sungjun
authors.initials: S
authors.lastname: Won
authors.affiliation: Ray Veterinary Medical Center, Seoul 06280, Korea.
authors.forename: Woo-Jo
authors.initials: WJ
authors.lastname: Chung
authors.affiliation: College of Veterinary Medicine and the Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Korea.
authors.forename: Junghee
authors.initials: J
authors.lastname: Yoon
mesh_terms: D000818:Animals; D015519:Bone Density; D050071:Bone Density Conservation Agents / Q000627:therapeutic use; D002371:Cat Diseases / Q000000981:diagnostic imaging* / Q000473:pathology; D002415:Cats; D004164:Diphosphonates / Q000627:therapeutic use; D008297:Male; D010013:Osteogenesis Imperfecta / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D011859:Radiography / Q000662:veterinary; D014057:Tomography, X-Ray Computed / Q000662:veterinary; D016896:Treatment Outcome
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates
keywords: cats; metabolic bone diseases; osteogenesis imperfecta; quantitative computed tomography