title: Mediastinal seminoma associated with multilocular thymic cyst.
abstract: An asymptomatic 26-year-old man received an annual medical check-up, and chest X-ray showed a protrusion of the aortopulmonary window. Chest computed tomography (CT) revealed an anterior mediastinal tumor and cysts with thin wall and septum enhancement. The preoperative diagnosis was cystic thymoma or malignant lymphoma. We performed total resection of the tumor through a median sternotomy. The pathological findings revealed seminoma, positive for c-kit stain, and multilocular thymic cysts. Cysts were lined by normal squamous epithelium and no seminoma cells were located on their surface. So, cysts were probably secondary changes caused by seminoma cells themselves or inflammatory stimulations. No invasion to adjacent structures was seen. After the surgery, testicular ultrasound imaging and abdominal, pelvic, and cerebral CT showed no apparent tumor or enlarged lymph nodes; however, an abnormal uptake in the right mesenteric lymph node was pointed out by18F-fluorodeoxyglucose-positron emission tomography (FDG-PET) scan. The patient received four courses of bleomycin, etoposide, and cisplatin (BEP) as adjuvant chemotherapy. Follow-up PET scan revealed no uptake in the right mesenteric lymph node. To date, no recurrence or metastasis has been identified for 16 months.
authors.affiliation: Department of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, Tokyo, Japan. minui-tky@umin.ac.jp.|Department of Thoracic Surgery, School of Medicine, The University of Tokyo Hospital, 7-3-1 Hongo Bunkyo-ku, Tokyo, 113-8655, Japan. minui-tky@umin.ac.jp.
authors.forename: Masato
authors.initials: M
authors.lastname: Inui
authors.affiliation: Department of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.
authors.forename: Jun-Ichi
authors.initials: JI
authors.lastname: Nitadori
authors.affiliation: Department of Pathology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.
authors.forename: Shogo
authors.initials: S
authors.lastname: Tajima
authors.affiliation: Department of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.
authors.forename: Takahusa
authors.initials: T
authors.lastname: Yoshioka
authors.affiliation: Department of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.
authors.forename: Noriko
authors.initials: N
authors.lastname: Hiyama
authors.affiliation: Department of Radiology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.
authors.forename: Takeyuki
authors.initials: T
authors.lastname: Watadani
authors.affiliation: Department of Pathology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.
authors.forename: Aya
authors.initials: A
authors.lastname: Shinozaki-Ushiku
authors.affiliation: Department of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Nagayama
authors.affiliation: Department of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Anraku
authors.affiliation: Department of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Sato
authors.affiliation: Department of Pathology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Fukayama
authors.affiliation: Department of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Nakajima
keywords: Mediastinal seminoma; Mediastinal tumor; Multilocular thymic cyst