title: Randomized, double-blind, comparative study of oral metronidazole and tinidazole in treatment of bacterial vaginosis.
abstract: OBJECTIVE
  To compare the efficacy and tolerability of oral metronidazole and tinidazole in patients with bacterial vaginosis (BV) using Amsel's criteria.
  
  
  METHODS
  This was a randomized double-blind study, conducted by the Departments of Pharmacology and Gynecology of a tertiary care teaching hospital. Patients diagnosed with BV received either tablet metronidazole 500 mg twice daily for 5 days or tablet tinidazole 500 mg once daily + one placebo for 5 days and instructed to come for follow-up at the 1stweek and 4thweek. They were categorized as cured, partially cured, and not cured based on Amsel's criteria at the end of the study and compared between two groups using Chi-square test.
  
  
  RESULTS
  A total 120 women were enrolled in the study, of which 114 completed the study. The treatment arms were comparable. The cure rate with low-dose tinidazole was significantly more compared to metronidazole at 4thweek (P= 0.0013), but not at 1stweek (P= 0.242). The adverse drug reactions were less with tinidazole compared to metronidazole.
  
  
  CONCLUSIONS
  Tinidazole at lower dose offers a better efficacy than metronidazole in long-term cure rates and in preventing relapses with better side effect profile.
authors.affiliation: Department of Pharmacology, Sri Venkateshwaraa Medical College, Puducherry, India.
authors.forename: Indu M
authors.initials: IM
authors.lastname: Raja
authors.affiliation: Department of Pharmacology, Sri Devaraj Urs Medical College, Tamaka, Kolar, Karnataka, India.
authors.forename: Asha
authors.initials: A
authors.lastname: Basavareddy
authors.affiliation: Department of Pharmacology, Sri Venkateshwaraa Medical College, Puducherry, India.
authors.forename: Deepali
authors.initials: D
authors.lastname: Mukherjee
authors.affiliation: Department of Pharmacology, All Institute of Medical Sciences, Bhubaneswar, Odisha, India.
authors.forename: Bikash Ranjan
authors.initials: BR
authors.lastname: Meher
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000890:Anti-Infective Agents / Q000008:administration & dosage; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008795:Metronidazole / Q000008:administration & dosage*; D008875:Middle Aged; D014011:Tinidazole / Q000008:administration & dosage*; D016896:Treatment Outcome; D016585:Vaginosis, Bacterial / Q000175:diagnosis* / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D000890:Anti-Infective Agents; D014011:Tinidazole; D008795:Metronidazole
keywords: Bacterial vaginosis; cure rate; metronidazole; tinidazole; tolerability