title: The seven faces of SIRT7.
abstract: SIRT7, a member of the sirtuin family of NAD+-dependent protein deacetylases, is a key mediator of many cellular activities. SIRT7 expression is linked to cell proliferation and oncogenic activity, connecting SIRT7-dependent regulation of ribosome biogenesis with checkpoints controlling cell cycle progression, metabolic homeostasis, stress resistance, aging and tumorigenesis. Despite this important functional link, the enzymatic activity, the molecular targets and physiological functions of SIRT7 are poorly defined. Here, we review recent progress in SIRT7 research and elaborate the main pathways in which SIRT7 participates.
authors.affiliation: a Molecular Biology of the Cell II , German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance , Heidelberg , Germany.
authors.forename: Maximilian F
authors.initials: MF
authors.lastname: Blank
authors.affiliation: a Molecular Biology of the Cell II , German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance , Heidelberg , Germany.
authors.forename: Ingrid
authors.initials: I
authors.lastname: Grummt
mesh_terms: D000818:Animals; D059447:Cell Cycle Checkpoints; D002471:Cell Transformation, Neoplastic; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D004734:Energy Metabolism; D042822:Genomic Instability; D006801:Humans; D012270:Ribosomes / Q000235:genetics / Q000378:metabolism; D037761:Sirtuins / Q000378:metabolism*; D013312:Stress, Physiological; D014158:Transcription, Genetic
chemical_list: D012321:DNA-Directed RNA Polymerases; D037761:Sirtuins
keywords: SIRT7; metabolism; stress response; transcription; tumorigenesis