title: Simultaneous multislice readout-segmented echo planar imaging for accelerated diffusion tensor imaging of the mandibular nerve: A feasibility study.
abstract: To assess the feasibility of diffusion tensor imaging (DTI) using simultaneous multislice (SMS) acquisition with blipped controlled aliasing in parallel imaging (CAIPI) for accelerated readout-segmented echo planar imaging (rs-EPI) of the mandibular nerves. DTI of the mandibular nerves using EPI is challenging due to susceptibility artifacts. Rs-EPI is less prone to artifacts but associated with longer scan durations.
  
  
  
  Eight asymptomatic volunteers were imaged at 3T using a 64-channel head/neck coil. Conventional, 2-fold (2xSMS) and 3-fold (3xSMS) slice-accelerated rs-EPI sequences were acquired. Tractography of the mandibular nerves was performed. Signal-to-noise ratio (SNR), fractional anisotropy (FA), mean diffusivity (MD), and number of tracts were calculated. Artifacts were evaluated qualitatively on Likert scales. Parameters were compared statistically. Clinical feasibility of 2xSMS rs-EPI was tested in four patients.
  
  
  
  SNR was similar for conventional (mean ± SD; 8.55 ± 3.90) and 2xSMS rs-EPI (7.83 ± 3.15) but lower for 3xSMS rs-EPI (5.42 ± 2.93; analysis of variance, P = 0.004). FA was similar for all sequences (rs-EPI, 0.42 ± 0.08; 2xSMS rs-EPI, 0.43 ± 0.08; 3xSMS rs-EPI, 0.44 ± 0.06), while 3xSMS rs-EPI showed lower MD (rs-EPI, 0.0015 ± 0.0003; 2xSMS rs-EPI, 0.0014 ± 0.0001; 3xSMS rs-EPI, 0.0013 ± 0.0003) and lower number of tracts (rs-EPI, 66.56 ± 51.31; 2xSMS rs-EPI, 65.75 ± 55.40; 3xSMS rs-EPI, 37.93 ± 52.42) compared to rs-EPI and 2xSMS rs-EPI. Additionally, 2xSMS rs-EPI was feasible in four clinical patients and provided robust imaging results.
  
  
  
  2xSMS rs-EPI yielded similar SNR, FA, and MD values compared to conventional rs-EPI at reduced scan time and is feasible in clinical patients. These findings suggest the potential clinical applicability of rs-EPI for DTI of the mandibular nerve.
  
  
  
  2 Technical Efficacy: Stage 1 J. MAGN. RESON. IMAGING 2017;46:663-677.
authors.affiliation: Institute for Diagnostic and Interventional Radiology, Department of Radiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.|Psychiatric University Hospital, Department of Psychiatry, Psychotherapy and Psychosomatics, University of Zurich, Zurich, Switzerland.
authors.forename: Andrei
authors.initials: A
authors.lastname: Manoliu
authors.affiliation: Institute for Diagnostic and Interventional Radiology, Department of Radiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
authors.forename: Michael
authors.initials: M
authors.lastname: Ho
authors.affiliation: Department of Neuroradiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
authors.forename: Marco
authors.initials: M
authors.lastname: Piccirelli
authors.affiliation: Institute for Diagnostic and Interventional Radiology, Department of Radiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
authors.forename: Daniel
authors.initials: D
authors.lastname: Nanz
authors.affiliation: Institute for Diagnostic and Interventional Radiology, Department of Radiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
authors.forename: Lukas
authors.identifier: 0000-0003-0574-5127
authors.initials: L
authors.lastname: Filli
authors.affiliation: Institute for Diagnostic and Interventional Radiology, Department of Radiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
authors.forename: Evelyn
authors.initials: E
authors.lastname: Dappa
authors.affiliation: Siemens Shenzhen Magnetic Resonance Ltd, Shenzhen, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.affiliation: Center of Dental Medicine, University of Zurich, Zurich, Switzerland.
authors.forename: Dominik A
authors.initials: DA
authors.lastname: Ettlin
authors.affiliation: Institute for Diagnostic and Interventional Radiology, Department of Radiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
authors.forename: Andreas
authors.initials: A
authors.lastname: Boss
authors.affiliation: Institute for Diagnostic and Interventional Radiology, Department of Radiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
authors.forename: Gustav
authors.initials: G
authors.lastname: Andreisek
authors.affiliation: Institute for Diagnostic and Interventional Radiology, Department of Radiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
authors.forename: Felix P
authors.initials: FP
authors.lastname: Kuhn
mesh_terms: D000328:Adult; D056324:Diffusion Tensor Imaging / Q000379:methods*; D017352:Echo-Planar Imaging / Q000379:methods*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008297:Male; D008340:Mandibular Nerve / Q000000981:diagnostic imaging*; D008875:Middle Aged; D015203:Reproducibility of Results; D055815:Young Adult
keywords: diffusion tensor imaging; diffusion tractography; mandibular nerve; simultaneous multislice echo-planar imaging