title: Recombinant hNeuritin Promotes Structural and Functional Recovery of Sciatic Nerve Injury in Rats.
abstract: Neuritin is a new neurotropic factor implicated in nervous system development and plasticity. Studies have shown that Neuritin is upregulated in injured nerves, suggesting that it is involved in nerve repair. To test this hypothesis, we investigated whether recombinant human Neuritin could restore nerve structure and function in a rat model of sciatic nerve injury. Neuritin treatment had a dose-dependent effect on functional recovery 4 weeks after injury, as determined by the walking-track test. Similar trends were observed for gastrocnemius muscular strength and nerve conduction velocity. Additionally, sciatic nerve fiber density and organization as well as degree of remyelination were increased, while growth-associated protein 43 and neurofilament 200 expression was upregulated upon treatment with Neuritin. These findings demonstrate that Neuritin stimulates nerve regeneration and functional recovery and thus promotes the repair of injured sciatic nerves.
authors.affiliation: The Key Laboratory of Xinjiang Endemic and Ethnic Diseases and Department of Biochemistry, Shihezi University School of Medicine Shihezi, China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Wang
authors.affiliation: Laboratory Medicine Department of Sixth People's Hospital of Chengdu, Chengdu, China.
authors.forename: Xinli
authors.initials: X
authors.lastname: Li
authors.affiliation: The Key Laboratory of Xinjiang Endemic and Ethnic Diseases and Department of Biochemistry, Shihezi University School of Medicine Shihezi, China.
authors.forename: Liya
authors.initials: L
authors.lastname: Shan
authors.affiliation: The Key Laboratory of Xinjiang Endemic and Ethnic Diseases and Department of Biochemistry, Shihezi University School of Medicine Shihezi, China.
authors.forename: Jingling
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Occupational and Environmental Health, Department of Preventive Medicine, School of Medicine, Hangzhou Normal University Hangzhou, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Chen
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, The Affiliated Hospital of Hangzhou Normal University Hangzhou, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Li
authors.affiliation: The Key Laboratory of Xinjiang Endemic and Ethnic Diseases and Department of Biochemistry, Shihezi University School of Medicine Shihezi, China.
authors.forename: Wumei
authors.initials: W
authors.lastname: Yuan
authors.affiliation: Occupational and Environmental Health, Department of Preventive Medicine, School of Medicine, Hangzhou Normal University Hangzhou, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Yang
authors.affiliation: The Key Laboratory of Xinjiang Endemic and Ethnic Diseases and Department of Biochemistry, Shihezi University School of Medicine Shihezi, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Huang
keywords: growth-associated protein 43; neuritin; neurofilament 200; restoration; sciatic nerve injury; walking-track test