title: Maternal undernutrition programs the apelinergic system of adipose tissue in adult male rat offspring.
abstract: Based on the Developmental Origin of Health and Disease concept, maternal undernutrition has been shown to sensitize adult offspring to metabolic pathologies such as obesity. Using a model of maternal 70% food restriction in pregnant female rats throughout gestation (called FR30), we previously reported that obesity-prone adult male rat offspring displayed hyperleptinemia with modifications in leptin and leptin receptor messenger RNA (mRNA) levels in white adipose tissue (WAT). Apelin is a member of the adipokine family that regulates various aspects of energy metabolism and WAT functionality. We investigated whether apelin and its receptor APJ could be a target of maternal undernutrition. Adult male rat offspring from FR30 dams showed increased plasma apelin levels and apelin gene expression in WAT. Post-weaning high-fat diet led to marked increase in APJ mRNA and protein levels in offspring's WAT. We demonstrate that maternal undernutrition and post-weaning diet have long-term consequences on the apelinergic system of adult male rat offspring.
authors.affiliation: 1EA4489,Équipe Malnutrition Maternelle et Programmation des Maladies Métaboliques,Univ. Lille,Lille,France.
authors.forename: S
authors.initials: S
authors.lastname: Lecoutre
authors.affiliation: 1EA4489,Équipe Malnutrition Maternelle et Programmation des Maladies Métaboliques,Univ. Lille,Lille,France.
authors.forename: L
authors.initials: L
authors.lastname: Marousez
authors.affiliation: 2European Associated Laboratory NeuroMicrobiota (INSERM/UCL),Team 3,IRSD,INSERM U1220,Toulouse,France.
authors.forename: A
authors.initials: A
authors.lastname: Drougard
authors.affiliation: 2European Associated Laboratory NeuroMicrobiota (INSERM/UCL),Team 3,IRSD,INSERM U1220,Toulouse,France.
authors.forename: C
authors.initials: C
authors.lastname: Knauf
authors.affiliation: 1EA4489,Équipe Malnutrition Maternelle et Programmation des Maladies Métaboliques,Univ. Lille,Lille,France.
authors.forename: C
authors.initials: C
authors.lastname: Guinez
authors.affiliation: 1EA4489,Équipe Malnutrition Maternelle et Programmation des Maladies Métaboliques,Univ. Lille,Lille,France.
authors.forename: D
authors.initials: D
authors.lastname: Eberlé
authors.affiliation: 1EA4489,Équipe Malnutrition Maternelle et Programmation des Maladies Métaboliques,Univ. Lille,Lille,France.
authors.forename: C
authors.initials: C
authors.lastname: Laborie
authors.affiliation: 1EA4489,Équipe Malnutrition Maternelle et Programmation des Maladies Métaboliques,Univ. Lille,Lille,France.
authors.forename: D
authors.initials: D
authors.lastname: Vieau
authors.affiliation: 1EA4489,Équipe Malnutrition Maternelle et Programmation des Maladies Métaboliques,Univ. Lille,Lille,France.
authors.forename: J
authors.initials: J
authors.lastname: Lesage
authors.affiliation: 1EA4489,Équipe Malnutrition Maternelle et Programmation des Maladies Métaboliques,Univ. Lille,Lille,France.
authors.forename: C
authors.initials: C
authors.lastname: Breton
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D000073861:Apelin / Q000378:metabolism*; D000075244:Apelin Receptors / Q000378:metabolism*; D001835:Body Weight; D004734:Energy Metabolism; D005260:Female; D020738:Leptin / Q000378:metabolism; D008297:Male; D044342:Malnutrition / Q000503:physiopathology*; D011247:Pregnancy; D051381:Rats
chemical_list: D000073861:Apelin; D000075244:Apelin Receptors; C498579:Apln protein, rat; C491284:Aplnr protein, rat; D020738:Leptin
keywords: APJ; HF diet; adipogenesis; apelin; fetal programming