title: Prediction of fetal loss by first-trimester crown-rump length in IVF pregnancies.
abstract: OBJECTIVE
  To evaluate the association between small crown-rump length (CRL) and fetal loss ≤22 weeks in IVF pregnancies.
  
  
  METHODS
  A retrospective analysis of prospectively collected data at a university-affiliated medical center. All singleton IVF pregnancies within a 5-year period, with a live embryo on first-trimester ultrasound and verified pregnancy outcome were included. Rates of fetal loss ≤22 weeks were compared between pregnancies with a CRL ≤tenth percentile and above the tenth percentile of our population.
  
  
  RESULTS
  Overall, 397 pregnancies met inclusion criteria. Ninety-five percent of CRL measurements were performed at 40-80 gestational days. All live-embryo's CRL measurements, from 40 to 80 mm, were plotted against expected gestational age (in 5-day clusters), with calculation of the tenth percentile for every gestational age. Total of 64 pregnancies had CRL ≤tenth percentile for gestational age. The rate of fetal loss in this group was significantly higher than in pregnancies with CRL >tenth percentile (17.2 vs. 6.6%, p = 0.005, OR = 2.93, 95% CI 1.2-6.7). In both groups, the majority of fetal losses occurred ≤10 weeks of gestation.
  
  
  CONCLUSIONS
  In IVF pregnancies with a live embryo, a small CRL at 40-80 days' gestation may predict fetal loss. Repeated ultrasound should be considered after 1-2 weeks.
authors.affiliation: IVF and Infertility Unit and Obstetrics and Gynecology Ultrasound Unit, Helen Schneider Hospital for Women, Rabin Medical Center, Beilinson Hospital, 4941492, Petach Tikva, Israel.|Sackler Faculty of Medicine, Tel Aviv University, 6997801, Tel Aviv, Israel.
authors.forename: Rinat
authors.initials: R
authors.lastname: Gabbay-Benziv
authors.affiliation: IVF and Infertility Unit and Obstetrics and Gynecology Ultrasound Unit, Helen Schneider Hospital for Women, Rabin Medical Center, Beilinson Hospital, 4941492, Petach Tikva, Israel.|Sackler Faculty of Medicine, Tel Aviv University, 6997801, Tel Aviv, Israel.
authors.forename: Amir
authors.initials: A
authors.lastname: Dolev
authors.affiliation: IVF and Infertility Unit and Obstetrics and Gynecology Ultrasound Unit, Helen Schneider Hospital for Women, Rabin Medical Center, Beilinson Hospital, 4941492, Petach Tikva, Israel.|Sackler Faculty of Medicine, Tel Aviv University, 6997801, Tel Aviv, Israel.
authors.forename: Ron
authors.initials: R
authors.lastname: Bardin
authors.affiliation: IVF and Infertility Unit and Obstetrics and Gynecology Ultrasound Unit, Helen Schneider Hospital for Women, Rabin Medical Center, Beilinson Hospital, 4941492, Petach Tikva, Israel.|Sackler Faculty of Medicine, Tel Aviv University, 6997801, Tel Aviv, Israel.
authors.forename: Israel
authors.initials: I
authors.lastname: Meizner
authors.affiliation: IVF and Infertility Unit and Obstetrics and Gynecology Ultrasound Unit, Helen Schneider Hospital for Women, Rabin Medical Center, Beilinson Hospital, 4941492, Petach Tikva, Israel.|Sackler Faculty of Medicine, Tel Aviv University, 6997801, Tel Aviv, Israel.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Fisch
authors.affiliation: IVF and Infertility Unit and Obstetrics and Gynecology Ultrasound Unit, Helen Schneider Hospital for Women, Rabin Medical Center, Beilinson Hospital, 4941492, Petach Tikva, Israel. benharoush@gmail.com.|Sackler Faculty of Medicine, Tel Aviv University, 6997801, Tel Aviv, Israel. benharoush@gmail.com.
authors.forename: Avi
authors.initials: A
authors.lastname: Ben-Haroush
mesh_terms: D000022:Abortion, Spontaneous / Q000209:etiology*; D000328:Adult; D018568:Crown-Rump Length; D005260:Female; D005307:Fertilization in Vitro; D005865:Gestational Age; D006801:Humans; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D012189:Retrospective Studies
keywords: Crown–rump length; Gestational age; IVF pregnancies; Miscarriage