title: Twelve weeks CLA supplementation decreases the hip circumference in overweight and obese women. A double-blind, randomized, placebo-controlled trial.
abstract: BACKGROUND
  Conjugated linoleic acid (CLA) reduces body weight (BW), body fat mass (BFM), and increases or maintains lean body mass in animals. However, the results concerning the effect of CLA on weight reduction in humans are contradictory. The present study aimed to evaluate the effect of CLA supplementation on the BW and anthropometric parameters (waist and hip circumferences) in overweight and obese adult women.
  
  
  METHODS
  A total of 74 subjects (BMI: 28-42 kg/m2) were included in a double blind, placebocontrolled trial. Subjects were randomized into two groups, those supplemented with either 3.0 g/d CLA or with placebo (sunflower oil) for 12 weeks.
  
  
  RESULTS
  CLA significantly decreased the hip circumferences compared to placebo (p = 0.016209), but had no effect on body weight, BMI, or waist circumference. The number of subjects with a reduction in hip circumference in the CLA group was significantly larger compared to that in the placebo group (p = 0.0017;  NNT= 2.65; CI [6.27-1.685]).
  
  
  CONCLUSIONS
  In conclusion, our findings do not support the hypothesis that 12 weeks CLA supplementation, as dosed in the present study, is effective for body weight reduction in overweight and obese women. However, its local action in decreasing the hip circumference seems to be encouraging and suggests that CLA may represent an attractive dietary supplement.
authors.affiliation: Department of Physiology, Poznan University of Medical Sciences, Poland.
authors.forename: Edyta
authors.initials: E
authors.lastname: Mądry
authors.affiliation: Department of Medical Microbiology, Poznan University of Medical Sciences, Poland.
authors.forename: Izabela
authors.initials: I
authors.lastname: Chudzicka-Strugała
authors.affiliation: Department of Internal Medicine, Metabolic Disorders and Hypertension, Poznan University of Medical Sciences, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Grabańska-Martyńska
authors.affiliation: Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poland.
authors.forename: Klaudia
authors.initials: K
authors.lastname: Malikowska
authors.affiliation: Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poland.
authors.forename: Philip
authors.initials: P
authors.lastname: Grebowiec
authors.affiliation: Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poland.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Lisowska
authors.affiliation: Department of Education and Obesity Treatment and Metabolic Disorders, Poznań University of Medical Sciences, Poland.
authors.forename: Paweł
authors.initials: P
authors.lastname: Bogdański
authors.affiliation: Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poland.
authors.forename: Jarosław
authors.initials: J
authors.lastname: Walkowiak
mesh_terms: D000328:Adult; D019440:Anti-Obesity Agents / Q000009:adverse effects / Q000627:therapeutic use*; D015992:Body Mass Index; D049628:Body Size; D019587:Dietary Supplements / Q000009:adverse effects; D004311:Double-Blind Method; D005260:Female; D006615:Hip; D006801:Humans; D044243:Linoleic Acids, Conjugated / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D009765:Obesity / Q000178:diet therapy*; D050177:Overweight / Q000178:diet therapy*; D010352:Patient Dropouts; D011044:Poland; D055105:Waist Circumference; D015431:Weight Loss
chemical_list: D019440:Anti-Obesity Agents; D044243:Linoleic Acids, Conjugated
keywords: BMI; CLA; body weight; hip circumference; placebo; waist circumference