title: GLP-2: A POORLY UNDERSTOOD MEDIATOR ENROLLED IN VARIOUS BARIATRIC/METABOLIC SURGERY-RELATED PATHOPHYSIOLOGIC MECHANISMS.
abstract: Glucagon-like peptide-2 (GLP-2) is a gastrointestinal hormone whose effects are predominantly trophic on the intestinal mucosa.
  
  
  
  Critically evaluate the current literature on the influence of bariatric/metabolic surgery on the levels of GLP-2 and its potential clinical implications.
  
  
  
  Narrative review through online research on the databases Medline and Lilacs. There were six prospective human studies, two cross-sectional human studies, and three experimental animal studies selected.
  
  
  
  There is evidence demonstrating significant increase in the levels of GLP-2 following gastric bypass, Scopinaro operation, and sleeve gastrectomy. There are no differences between gastric bypass and sleeve gastrectomy in regards to the increase in the GLP-2 levels. There is no correlation between the postoperative levels of GLP-2 and the occurrence of adequate or insufficient postoperative weight loss.
  
  
  
  GLP-2 plays significant roles on the regulation of nutrient absorption, permeability of gut mucosa, control of bone resorption, and regulation of satiety. The overall impact of these effects potentially exerts a significant adaptive or compensatory effect within the context of varied bariatric surgical techniques.
authors.affiliation: Department of Surgery.
authors.forename: Everton
authors.initials: E
authors.lastname: Cazzo
authors.affiliation: Department of Surgery.
authors.forename: Martinho Antonio
authors.initials: MA
authors.lastname: Gestic
authors.affiliation: Department of Surgery.
authors.forename: Murillo Pimentel
authors.initials: MP
authors.lastname: Utrini
authors.affiliation: Department of Surgery.
authors.forename: Felipe David Mendonça
authors.initials: FD
authors.lastname: Chaim
authors.affiliation: Research Laboratory in Metabology and Diabetes (Limed), State University of Campinas - Unicamp, Campinas, SP, Brazil.
authors.forename: Bruno
authors.initials: B
authors.lastname: Geloneze
authors.affiliation: Department of Surgery.
authors.forename: José Carlos
authors.initials: JC
authors.lastname: Pareja
authors.affiliation: Department of Surgery.
authors.forename: Elinton Adami
authors.initials: EA
authors.lastname: Chaim
authors.affiliation: Department of Surgery.
authors.forename: Daniéla Oliveira
authors.initials: DO
authors.lastname: Magro
mesh_terms: D050110:Bariatric Surgery; D015390:Gastric Bypass; D053767:Glucagon-Like Peptide 2 / Q000502:physiology*; D006801:Humans; D011183:Postoperative Complications / Q000503:physiopathology*
chemical_list: D053767:Glucagon-Like Peptide 2