title: Chemotherapy-Induced Neuropathy in Cancer Survivors.
abstract: Evidence suggests that chemotherapy-induced neuropathy (CIN) is a significant problem for cancer survivors. However, a detailed phenotypic characterization of CIN in cancer survivors is not available.
  
  
  
  To evaluate between-group differences in demographic and clinical characteristics, as well as in measures of sensation, function, and postural control, in a sample of cancer survivors who received a platinum and/or a taxane-based CTX regimen and did (n = 426) and did not (n = 197) develop CIN.
  
  
  
  Survivors completed self-report questionnaires and underwent objective testing (i.e., light touch, pain sensation, cold sensation, vibration, muscle strength, grip strength, Purdue Pegboard test, Timed Get Up and Go test, Fullerton Advanced Balance test). Parametric and nonparametric statistics were used to compare between-group differences in study outcomes.
  
  
  
  Of the 426 survivors with CIN, 4.9% had CIN only in their upper extremities, 27.0% only in their lower extremities, and 68.1% in both their upper and lower extremities. Demographic and clinical characteristics associated with CIN included the following: older age, lower annual income, higher body mass index, a higher level of comorbidity, being born prematurely, receipt of a higher cumulative dose of chemotherapy, and a poorer functional status. Survivors with CIN had worse outcomes for all of the following objective measures: light touch, pain, temperature, vibration, upper and lower extremity function, and balance.
  
  
  
  This study is the first to provide a detailed phenotypic characterization of CIN in cancer survivors who received a platinum and/or a taxane compound. These data can serve as a benchmark for future studies of CIN in cancer survivors.
authors.affiliation: School of Nursing, University of California, San Francisco, California, USA. Electronic address: chris.miaskowski@ucsf.edu.
authors.forename: Christine
authors.initials: C
authors.lastname: Miaskowski
authors.affiliation: School of Nursing, University of California, San Francisco, California, USA.
authors.forename: Judy
authors.initials: J
authors.lastname: Mastick
authors.affiliation: School of Nursing, University of California, San Francisco, California, USA.
authors.forename: Steven M
authors.initials: SM
authors.lastname: Paul
authors.affiliation: School of Medicine, University of California, San Francisco, California, USA.
authors.forename: Kimberly
authors.initials: K
authors.lastname: Topp
authors.affiliation: School of Medicine, University of California, San Francisco, California, USA.
authors.forename: Betty
authors.initials: B
authors.lastname: Smoot
authors.affiliation: School of Medicine, University of California, San Francisco, California, USA.
authors.forename: Gary
authors.initials: G
authors.lastname: Abrams
authors.affiliation: School of Medicine, University of California, San Francisco, California, USA.
authors.forename: Lee-May
authors.initials: LM
authors.lastname: Chen
authors.affiliation: School of Nursing, University of California, San Francisco, California, USA.
authors.forename: Kord M
authors.initials: KM
authors.lastname: Kober
authors.affiliation: School of Nursing, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
authors.forename: Yvette P
authors.initials: YP
authors.lastname: Conley
authors.affiliation: School of Medicine, University of California, San Francisco, California, USA.
authors.forename: Margaret
authors.initials: M
authors.lastname: Chesney
authors.affiliation: School of Nursing, University of California, San Francisco, California, USA.
authors.forename: Kay
authors.initials: K
authors.lastname: Bolla
authors.affiliation: School of Nursing, University of California, San Francisco, California, USA.
authors.forename: Grace
authors.initials: G
authors.lastname: Mausisa
authors.affiliation: School of Nursing, University of California, San Francisco, California, USA.
authors.forename: Melissa
authors.initials: M
authors.lastname: Mazor
authors.affiliation: School of Medicine, University of California, San Francisco, California, USA.
authors.forename: Melisa
authors.initials: M
authors.lastname: Wong
authors.affiliation: School of Medicine, University of California, San Francisco, California, USA.
authors.forename: Mark
authors.initials: M
authors.lastname: Schumacher
authors.affiliation: School of Medicine, University of California, San Francisco, California, USA.
authors.forename: Jon D
authors.initials: JD
authors.lastname: Levine
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000073116:Cancer Survivors; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000453:epidemiology / Q000503:physiopathology*; D010808:Physical Examination; D017671:Platinum Compounds / Q000009:adverse effects / Q000627:therapeutic use; D057566:Self Report; D043823:Taxoids / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D017671:Platinum Compounds; D043823:Taxoids
keywords: Chemotherapy-induced neuropathy; balance; cancer; chemotherapy; gait; pain; pain qualities; sensations; vibration