title: Reactivated astrocytes as a possible source of oligodendrocyte precursors for remyelination in remitting phase of experimental autoimmune encephalomyelitis rats.
abstract: Multiple sclerosis (MS) is ademyelinating disease in the central nervous system (CNS). Majority of the MS patients show relapsing-remitting disease course. Evidences show that oligodendrocyte precursor cells (OPCs), which remain relatively quiescent in normal adult CNS, play a key role in the remitting phase by proliferation and remyelination. In the present study, we found that spinal cord astrocytesco-expressed progenitor cell marker and oligodendroglial lineage markers in the remittance phase in adult rat experimental autoimmune encephalomyelitis (EAE) model. We suggest that activated astrocyte could de-differentiate into OPCs and re-differentiate into mature oligodendrocytes, raising the possibility that astrocytes can be a potential source of OPCs in the adult demyelinated spinal cord.
authors.affiliation: Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong KongPokfulam, Hong Kong SAR, China; Laboratory of Clinical Medical Research, Beijing Tiantan Hospital, Capital Medical UniversityBeijing, China; Key Laboratory of Translational Medicine for Cerebrovascular DiseaseBeijing, China.
authors.forename: An-Chen
authors.initials: AC
authors.lastname: Guo
authors.affiliation: Research Center of Reproduction, Development and Growth, Li Ka Shing Faculty of Medicine, The University of Hong Kong Pokfulam, Hong Kong SAR, China.
authors.forename: Takho
authors.initials: T
authors.lastname: Chu
authors.affiliation: Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong Pokfulam, Hong Kong SAR, China.
authors.forename: Xu-Qing
authors.initials: XQ
authors.lastname: Liu
authors.affiliation: Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong Pokfulam, Hong Kong SAR, China.
authors.forename: Huan-Xing
authors.initials: HX
authors.lastname: Su
authors.affiliation: Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong KongPokfulam, Hong Kong SAR, China; State Key Laboratory for Brain and Cognitive Sciences, The University of Hong KongPokfulam, Hong Kong SAR, China; GHM Institute of CNS Regeneration, Jinan UniversityGuangzhou, China.
authors.forename: Wu-Tian
authors.initials: WT
authors.lastname: Wu
keywords: Oligodendrocyte; astrocytesco; encephalomyelitis; multiple sclerosis (MS)