title: Targeting microRNAs: a new action mechanism of natural compounds.
abstract: Unlike genetics, epigenetics involves the modification of genome without changes in DNA sequences, including DNA methylation, histone modification, chromatin remodeling and noncoding RNA regulation. MicroRNA (miRNA), a member of noncoding RNAs superfamily, participates in RNA interference through a unique mechanism. Currently, microRNAs have been found to be regulated by some natural compounds. Through altering the expression of miRNAs and influencing the downstream signaling pathways or target genes, several natural compounds exhibit its bioactivity in the prevention, diagnosis, therapy, prognosis and drug resistance of human diseases, such as cancer. In this review, several natural compounds and their studies about miRNA-related action mechanism were summarized. These studies provide a new insight into action mechanism by which natural compound exerts its bioactivity and a novel treatment strategy, demonstrating natural compound a promising remedy for clinical treatments.
authors.affiliation: College of Medicine, Qingdao University, Qingdao, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Lin
authors.affiliation: The Department of Oncology, The First Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.
authors.forename: Leina
authors.initials: L
authors.lastname: Ma
authors.affiliation: College of Medicine, Qingdao University, Qingdao, China.
authors.forename: Zhantao
authors.initials: Z
authors.lastname: Liu
authors.affiliation: College of Medicine, Qingdao University, Qingdao, China.
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Yang
authors.affiliation: College of Medicine, Qingdao University, Qingdao, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Wang
authors.affiliation: College of Medicine, Qingdao University, Qingdao, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Liu
authors.affiliation: College of Medicine, Qingdao University, Qingdao, China.
authors.forename: Guohui
authors.initials: G
authors.lastname: Jiang
mesh_terms: D001688:Biological Products / Q000378:metabolism / Q000627:therapeutic use*; D057890:Epigenomics / Q000379:methods*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*
chemical_list: D001688:Biological Products; D035683:MicroRNAs
keywords: cancer; miRNAs; natural compounds