title: To Study the Correlation of Thompson Scoring in Predicting Early Neonatal Outcome in Post Asphyxiated Term Neonates.
abstract: BACKGROUND
  Throughout the world each year, an estimated 23% of the 4 million neonatal deaths and 8% of all deaths in <5 years of age are associated with signs of asphyxia at birth.
  
  
  OBJECTIVE
  To study the role of cord arterial blood gas analysis at birth and serial Thompson score in predicting the early neonatal outcome in post asphyxiated term neonates.
  
  
  METHODS
  The study was conducted in Department of Paediatrics, in Neonatal Intensive Care Unit (NICU), Hindu Rao Hospital, New Delhi from May 2014 to February. 2015. This study was a prospective cross-sectional study. During this period, a total of 145 post asphyxiated term neonates born in labour room/obstetric operation theatre were recruited. An informed consent was taken from all the parents. The protocol was approved by the institutional ethical committee. Inclusion criteria were full-term babies with low-Apgar score i.e., 1 min score of ≤ 7 National Neonatal Perinatal Database 2010 (NNPD 2010).
  
  
  METHODS
  SPSS 17.0 Software has been used for data analysis. The data were expressed in terms of Means, Standard Deviation and Proportion, followed by comparison between groups through chi-square test or Fisher's-exact test. A p-value of less than 0.05 was considered as statistically significant.
  
  
  RESULTS
  The present study was carried out on 145 post asphyxiated full-term babies with low-Apgar score i.e., 1min score of ≤7mild Thompson score on day I,2,3 were 96 (66.2%), 119 (82.06%), 125 (86.20%), moderate Thompson score on day 1,3, 7 were 13 (8.9%), 6 (4.13%), 2 (1.37%) and severe Thompson score on day 1, 3, 7 were 36 (24.8%), 13 (8.96%), 7 (4.82%) respectively. Total 11 patients died out of 145 post asphyxiated full-term babies within 7 days, among 11 patients, 7 died within 3 days. There was clinical improvement among HIE patients as indicated by serial Thompson score done on day 1, 3 and 7. Among 145 patients 62(42.8%) had seizure and 83(57.2%) did not have seizure. Most common type of seizure was subtle seizure in 25 (40.3%) followed by multifocal in 21 (33.9%) and tonic in 16(25.8%).
  
  
  CONCLUSIONS
  There is statistically significant correlation between morbidity and day 1 Thompson score (p-value 0.024). There is statistically significant correlation between mortality and day 1 Thompson score (p-value 0.001). Thompson score allows a very precise description of infants by assigning a numeric score rather than 'mild', 'moderate' or 'severe'. Inter-rater reliability is very good with a kappa co-efficient of 0.87.
authors.affiliation: Senior Pediatrician, Department of Paediatrics, Hindu Rao Hospital , Delhi, India .
authors.forename: Dalip Kumar
authors.initials: DK
authors.lastname: Bhagwani
authors.affiliation: Senior Specialist, Department of Obstetrics and Gynaecology, Hindu Rao Hospital , Delhi, India .
authors.forename: Manisha
authors.initials: M
authors.lastname: Sharma
authors.affiliation: Senior Resident, Department of Paediatrics, Hindu Rao Hospital , Delhi, India .
authors.forename: Stanzin
authors.initials: S
authors.lastname: Dolker
authors.affiliation: CMO(SAG), Department of Paediatrics, Hindu Rao Hospital , Delhi, India .
authors.forename: Sharada
authors.initials: S
authors.lastname: Kothapalli
keywords: Cord blood gas; Hypoxic ischemic encephalopathy; Maternal risk factor; Seizures