title: Formyl Peptide Receptors in Cellular Differentiation and Inflammatory Diseases.
abstract: Formyl peptide receptors (FPRs) are a family of classical chemoattractant receptors. Although FPRs are mainly expressed in phagocytic innate immune cells including monocytes/macrophages and neutrophils, recent reports demonstrated that additional different cell types such as T-lymphocytes and several non-immune cells also express functional FPRs. FPRs were first reported as a specific receptor to detect bacteria-derived N-formyl peptides. However, accumulating evidence has shown that FPRs can recognize various ligands derived from pathogens, mitochondria, and host. This review summarizes studies on some interesting endogenous agonists for FPRs. Here, we discuss functional roles of FPRs and their ligands concerning the regulation of cellular differentiation focusing on myeloid lineage cells. Accumulating evidence also suggests that FPRs may contribute to the control of inflammatory diseases. Here, we briefly review the current understanding of the functional role of FPRs and their ligands in inflammatory disorders in some animal disease models. J. Cell. Biochem. 118: 1300-1307, 2017. © 2017 Wiley Periodicals, Inc.
authors.affiliation: Department of Biological Sciences, Sungkyunkwan University, Suwon 16419, Republic of Korea.
authors.forename: Ha Young
authors.initials: HY
authors.lastname: Lee
authors.affiliation: Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul 06351, Republic of Korea.
authors.forename: Mingyu
authors.initials: M
authors.lastname: Lee
authors.affiliation: Department of Biological Sciences, Sungkyunkwan University, Suwon 16419, Republic of Korea.|Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul 06351, Republic of Korea.
authors.forename: Yoe-Sik
authors.identifier: 0000-0002-6198-4512
authors.initials: YS
authors.lastname: Bae
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D004195:Disease Models, Animal; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D008024:Ligands; D022423:Myeloid Cells / Q000166:cytology* / Q000378:metabolism; D044042:Receptors, Formyl Peptide / Q000819:agonists / Q000378:metabolism*
chemical_list: D008024:Ligands; D044042:Receptors, Formyl Peptide
keywords: CELLULAR DIFFERENTIATION; FORMYL PEPTIDE RECEPTOR; INFLAMMATORY DISEASE