title: Diterpenoid alkaloids from the root of Aconitum sinchiangense W. T. Wang with their antitumor and antibacterial activities.
abstract: A phytochemical study of the root barks of Aconitum sinchiangense W. T. Wang, a traditional Chinese herb medicine, led to the isolation of 15 diterpenoid alkaloids, including one new C19-diterpenoid alkaloid, sinchiangensine A (1), whose structure was determined by spectral methods including 2D NMR. Additionally, sinchiangensine A and its known analogue 3 were first reported as potential antitumor and antibacterial diterpenoid alkaloids, which showed significant antitumor activities against tumour cells (HL-60, A-549, SMCC-7721, MCF-7 and SW480), with IC50comparable to cisplatin, and significant antibacterial activities against Staphylococcus aureus ATCC-25923 with MIC value of 0.147 and 0.144 μmol/mL, respectively.
authors.affiliation: a Natural Medicine Research Center, College of Veterinary Medicine , Sichuan Agricultural University , Chengdu , P.R. China.
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Liang
authors.affiliation: a Natural Medicine Research Center, College of Veterinary Medicine , Sichuan Agricultural University , Chengdu , P.R. China.
authors.forename: Lan
authors.initials: L
authors.lastname: Chen
authors.affiliation: b College of Pharmacy , Southwest University for Nationalities , Chengdu , P.R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Song
authors.affiliation: a Natural Medicine Research Center, College of Veterinary Medicine , Sichuan Agricultural University , Chengdu , P.R. China.
authors.forename: Wenbo
authors.initials: W
authors.lastname: Fei
authors.affiliation: a Natural Medicine Research Center, College of Veterinary Medicine , Sichuan Agricultural University , Chengdu , P.R. China.
authors.forename: Min
authors.initials: M
authors.lastname: He
authors.affiliation: a Natural Medicine Research Center, College of Veterinary Medicine , Sichuan Agricultural University , Chengdu , P.R. China.
authors.forename: Changliang
authors.initials: C
authors.lastname: He
authors.affiliation: a Natural Medicine Research Center, College of Veterinary Medicine , Sichuan Agricultural University , Chengdu , P.R. China.
authors.forename: Zhongqiong
authors.initials: Z
authors.lastname: Yin
mesh_terms: D031841:Aconitum / Q000737:chemistry*; D000470:Alkaloids / Q000737:chemistry* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002945:Cisplatin / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D008516:Medicine, Chinese Traditional; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000470:Alkaloids; D000900:Anti-Bacterial Agents; D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D002945:Cisplatin
keywords: Aconitum sinchiangense W. T. Wang; antibacterial activity; antitumor activity; diterpenoid alkaloids; sinchiangensine A