title: Seizure following chemotherapy (paclitaxel and cisplatin) in a patient of carcinoma cervix.
abstract: Cisplatin and paclitaxel both can cause peripheral neurotoxicity as an adverse effect; however, central nervous system neurotoxicity in the form of seizures is rare. We report a case of a 36-year-old female patient of metastatic carcinoma cervix, who developed seizure shortly after cisplatin infusion. Her laboratory investigations were within normal limits. Computed tomography scan and magnetic resonance imaging of the brain did not reveal brain primary metastasis or meningeal carcinomatosis. She had no complaints of fever, no signs and symptoms of infection, and no history of seizure nor was she on any medication predisposing to such an event. Excluding several causes, seizure was thought to be most likely related to the chemotherapy and cisplatin was the more likely agent in view of observed temporal relationship with the adverse event.
authors.affiliation: Department of Radiotherapy, SMS Medical College, Jaipur, Rajasthan, India.
authors.forename: Rohitashwa
authors.initials: R
authors.lastname: Dana
authors.affiliation: Department of Radiotherapy, Dr. S.N. Medical College, Jodhpur, Rajasthan, India.
authors.forename: R K
authors.initials: RK
authors.lastname: Spartacus
authors.affiliation: Department of Radiotherapy, Dr. S.N. Medical College, Jodhpur, Rajasthan, India.
authors.forename: Shweta
authors.initials: S
authors.lastname: Mutha
authors.affiliation: Department of Radiotherapy, Dr. S.N. Medical College, Jodhpur, Rajasthan, India.
authors.forename: Prashanth
authors.initials: P
authors.lastname: Bhat
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects*; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D017239:Paclitaxel / Q000008:administration & dosage / Q000009:adverse effects*; D012640:Seizures / Q000139:chemically induced* / Q000000981:diagnostic imaging*; D002583:Uterine Cervical Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy*
chemical_list: D017239:Paclitaxel; D002945:Cisplatin
keywords: Carcinoma; cervix; chemotherapy; seizure