title: Unconventional Pathways of Secretion Contribute to Inflammation.
abstract: In the conventional pathway of protein secretion, leader sequence-containing proteins leave the cell following processing through the endoplasmic reticulum (ER) and Golgi body. However, leaderless proteins also enter the extracellular space through mechanisms collectively known as unconventional secretion. Unconventionally secreted proteins often have vital roles in cell and organism function such as inflammation. Amongst the best-studied inflammatory unconventionally secreted proteins are interleukin (IL)-1β, IL-1α, IL-33 and high-mobility group box 1 (HMGB1). In this review we discuss the current understanding of the unconventional secretion of these proteins and highlight future areas of research such as the role of nuclear localisation.
authors.affiliation: Division of Neuroscience and Experimental Psychology, Faculty of Biology, Medicine and Health, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PT, UK. michael.daniels@postgrad.manchester.ac.uk.
authors.forename: Michael J D
authors.initials: MJ
authors.lastname: Daniels
authors.affiliation: Division of Neuroscience and Experimental Psychology, Faculty of Biology, Medicine and Health, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PT, UK. david.brough@manchester.ac.uk.
authors.forename: David
authors.initials: D
authors.lastname: Brough
mesh_terms: D000818:Animals; D005110:Extracellular Space / Q000378:metabolism; D024243:HMGB1 Protein / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D053582:Interleukin-1alpha / Q000378:metabolism*; D053583:Interleukin-1beta / Q000378:metabolism*; D000067596:Interleukin-33 / Q000378:metabolism*; D008954:Models, Biological; D021381:Protein Transport
chemical_list: D024243:HMGB1 Protein; D053582:Interleukin-1alpha; D053583:Interleukin-1beta; D000067596:Interleukin-33
keywords: HMGB1; IL-1α; IL-1β; IL-33; inflammasome; nuclear localisation; unconventional secretion