title: Effects of the chronic restraint stress induced depression on reward-related learning in rats.
abstract: Chronic mild or unpredictability stress produces a persistent depressive-like state. The main symptoms of depression include weight loss, despair, anhedonia, diminished motivation and mild cognition impairment, which could influence the ability of reward-related learning. In the present study, we aimed to evaluate the effects of chronic restraint stress on the performance of reward-related learning of rats. We used the exposure of repeated restraint stress (6h/day, for 28days) to induce depression-like behavior in rats. Then designed tasks including Pavlovian conditioning (magazine head entries), acquisition and maintenance of instrumental conditioning (lever pressing) and goal directed learning (higher fixed ratio schedule of reinforcement) to study the effects of chronic restraint stress. The results indicated that chronic restraint stress influenced rats in those aspects including the acquisition of a Pavlovian stimulus-outcome (S-O) association, the formation and maintenance of action-outcome (A-O) causal relation and the ability of learning in higher fixed ratio schedule. In conclusion, depression could influence the performances in reward-related learning obviously and the series of instrumental learning tasks may have potential as a method to evaluate cognitive changes in depression.
authors.affiliation: Research Center for Pharmacology & Toxicology, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Pan
authors.initials: P
authors.lastname: Xu
authors.affiliation: Research Center for Pharmacology & Toxicology, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Kezhu
authors.initials: K
authors.lastname: Wang
authors.affiliation: Research Center for Pharmacology & Toxicology, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Cong
authors.initials: C
authors.lastname: Lu
authors.affiliation: Research Center for Pharmacology & Toxicology, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Liming
authors.initials: L
authors.lastname: Dong
authors.affiliation: Southwest Medical University, Luzhou, 646000, China.
authors.forename: Yixi
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Southwest Medical University, Luzhou, 646000, China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Research Center for Pharmacology & Toxicology, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Shi
authors.affiliation: China Astronaut Research and Training Center, Yuanmingyuan West Road No. 1, Beijing, 100094, China.
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Yang
authors.affiliation: China Astronaut Research and Training Center, Yuanmingyuan West Road No. 1, Beijing, 100094, China.
authors.forename: Shanguang
authors.initials: S
authors.lastname: Chen
authors.affiliation: Research Center for Pharmacology & Toxicology, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address: liuxinmin@hotmail.com.
authors.forename: Xinmin
authors.initials: X
authors.lastname: Liu
mesh_terms: D000818:Animals; D002908:Chronic Disease; D003214:Conditioning, Classical; D003216:Conditioning, Operant; D003866:Depressive Disorder; D004195:Disease Models, Animal; D006185:Habituation, Psychophysiologic; D007859:Learning Disabilities / Q000209:etiology; D008297:Male; D009043:Motor Activity; D011897:Random Allocation; D017208:Rats, Wistar; D012149:Restraint, Physical; D012201:Reward; D013315:Stress, Psychological
keywords: Chronic restraint stress; Depression; Instrumental learning; Rat; Reward