title: Evaluation on biological compatibility of carboxymethyl chitosan as biomaterials for antitumor drug delivery.
abstract: Carboxymethyl-chitosan, a water-soluble derivative of chitosan, has emerged as a promising candidate for biomedical applications due to its excellent water solubility, biodegradation, biocompatibility, hydrating, antimicrobial, and nontoxicity. In this paper, the antitumor proliferation and metastasis was studied in vitro and in vivo to evaluate biocompatibility of carboxymethyl-chitosan as biomaterials for antitumor drug delivery. The results showed that carboxymethyl-chitosan could significantly reduce the clone formation and tumor migration of human cancer cells including kidney cancer cell line OS-RC-2, gastric cancer cell line SGC-7901, colon cancer cell line HT-29, and nonsmall cell lung cancer cell line NCI-H1650 in vitro. Through Lewis tumor-bearing C57BL/6 mouse model, carboxymethyl-chitosan was proved to be able to inhibit solid tumor growth and tumor metastasis to the liver and lung, meanwhile increase the level of tissue inhibitor of metalloproteinase 1 and E-cadherin, and decrease the level of mice blood serum matrix metalloproteinase 9. This study suggested that carboxymethyl-chitosan had certain antimetastasis effect and good biocompatibility and may have a potential application as a synergic antitumor reagent.
authors.affiliation: Ocean University of China, Qingdao, China.
authors.forename: Zhiwen
authors.initials: Z
authors.lastname: Jiang
authors.affiliation: Ocean University of China, Qingdao, China.
authors.forename: Baoqin
authors.initials: B
authors.lastname: Han
authors.affiliation: Ocean University of China, Qingdao, China.
authors.forename: Wanshun
authors.initials: W
authors.lastname: Liu
authors.affiliation: Ocean University of China, Qingdao, China.
authors.forename: Yanfei
authors.initials: Y
authors.lastname: Peng
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry; D001672:Biocompatible Materials / Q000008:administration & dosage / Q000737:chemistry; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D048271:Chitosan / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry; D004058:Diffusion; D004339:Drug Compounding / Q000379:methods; D019073:HT29 Cells; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D009362:Neoplasm Metastasis / Q000188:drug therapy / Q000473:pathology / Q000517:prevention & control*; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D001672:Biocompatible Materials; C514968:carboxymethyl-chitosan; D048271:Chitosan
keywords: Carboxymethyl-chitosan; biocompatibility; in vitro; in vivo; tumor growth; tumor metastasis