title: Melorheostosis with recurrent soft-tissue components: a histologically confirmed case.
abstract: Melorheostosis is a very rare disorder characterized by irregular cortical thickening seen on radiographs. In this paper, we present a case of melorheostosis with microscopically confirmed soft-tissue components. The patient was a 51-year-old man who complained of severe pain in the lateral aspect of his right knee. The excision of an ossified soft-tissue lesion relieved intractable pain that had lasted 20 years. Microscopically, the cortex of the affected fibula was composed of thick compact bone and the soft-tissue component consisted of dense compact bone without endochondral ossification. The presence of soft-tissue osseous nodules around the joints is one of the specific conditions for melorheostosis and should be differentiated from synovial chondromatosis. The ossified soft-tissue lesion in our patient is to our knowledge the first reported case of the histologically confirmed soft-tissue component of melorheostosis, which differs from that of synovial chondromatosis.
authors.affiliation: Department of Orthopaedic Surgery, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya-ku, Saitama, 330-8503, Saitama, Japan.
authors.forename: Shoichi
authors.initials: S
authors.lastname: Hasegawa
authors.affiliation: Department of Orthopaedic Surgery, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya-ku, Saitama, 330-8503, Saitama, Japan.
authors.forename: Shotaro
authors.initials: S
authors.lastname: Kanda
authors.affiliation: Department of Pathology, Dokkyo Medical University Koshigaya Hospital, No. 1-50, 2-Chome, Minami-Koshigaya, Koshigaya-shi, Saitama, 343-8555, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Imada
authors.affiliation: Department of Pathology, Dokkyo Medical University Koshigaya Hospital, No. 1-50, 2-Chome, Minami-Koshigaya, Koshigaya-shi, Saitama, 343-8555, Japan.
authors.forename: Takehiko
authors.initials: T
authors.lastname: Yamaguchi
authors.affiliation: Department of Orthopaedic Surgery, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya-ku, Saitama, 330-8503, Saitama, Japan. toruakiyama827@jichi.ac.jp.
authors.forename: Toru
authors.initials: T
authors.lastname: Akiyama
mesh_terms: D003287:Contrast Media; D003937:Diagnosis, Differential; D006801:Humans; D007719:Knee Joint / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008297:Male; D008557:Melorheostosis / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media
keywords: Melorheostosis; Pathological confirmation; Soft-tissue component; Surgical treatment