title: [DNA tandem lesion: 5',8-cyclo-2'-deoxyadenosine. The influence on human health].
abstract: Nucleic acids are the targets for various endogenous and exogenous genotoxic agents, including reactive oxygen species. The appearance of a hydroxyl racial (^(.)OH), the most harmful molecule, next to an oligonucleotide can lead to two types of DNA damage: strand breaks or nucleobase modifications. Since clustered DNA damage is defined as the presence of two or more lesions in one helix turn, purine 5',8-cyclo-2'-deoxynucleosides are recognized as tandem lesions: both sugar moieties and base have been modified within one nucleoside/nucleotide. The hydrogen abstraction from the C5' group of nucleosides/nucleotides by ^(.)OH, with subsequent C8 C5' cyclisation results in purine 5',8-cyclonucleoside formation. Due to its unusual 3D structure and the fact that only one radical hit is needed for purine 5',8-cyclonucleoside formation their influence on genome stability/integrity and DNA repair processes are subjects of medical interest. In the present work the influence of 5',8-cyclo-2'-deoxyadenosine on DNA spatial geometry and DNA repair hinder in connection with human health, such as neurological disorders is discussed.
authors.affiliation: Food Science Department, Faculty of Pharmacy, Medical University of Lodz, Lodz, Poland.|anna.merecz@umed.lodz.pl.
authors.forename: A
authors.initials: A
authors.lastname: Merecz
authors.affiliation: Food Science Department, Faculty of Pharmacy, Medical University of Lodz, Lodz, Poland.
authors.forename: B T
authors.initials: BT
authors.lastname: Karwowski
mesh_terms: D053903:DNA Breaks, Double-Stranded; D004260:DNA Repair; D003839:Deoxyadenosines / Q000378:metabolism*; D042822:Genomic Instability; D006801:Humans; D017665:Hydroxyl Radical / Q000378:metabolism*; D009422:Nervous System Diseases / Q000378:metabolism*; D009690:Nucleic Acid Conformation
chemical_list: D003839:Deoxyadenosines; C056752:8,5'-cyclo-2'-deoxyadenosine; D017665:Hydroxyl Radical
keywords: 5'; 8-cyclo-2'-deoxyadenosine; hydroxyl radical; neurological disorders; nucleotide excision repair