title: Peroxisomes (Microbodies) in Human Liver: Cytochemical and Quantitative Studies of 85 Biopsies12.
abstract: The number, intracellular distribution, and staining characteristics of human hepatocellular peroxisomes that had been made visible by cytochemical staining for catalase were evaluated in biopsies from 75 patients with hepatic, inflammatory, or malignant disease and ten normal individuals. Intensity of staining was found to be proportional to enzymatic activity by microspectrophotometry. Scanning transmission electron microscopy (STEM) image analysis demonstrated an inverse relationship between peroxisomal size and contrast. Peroxisomes were more abundant, and often concentrated in a perinuclear configuration in cholestatic and cirrhotic livers. Decreased peroxisomal staining was common in cholestasis, cirrhosis, hepatitis, and in almost all patients with malignancies, both with and without hepatic metastases.
authors.affiliation: Menselijki Anatomie (F.R.; M.P.; A.C.; I.K.; P. v.d.S.), Gastroenterologie. Akademisch Ziekenhuis (G.G.), and Patologische Ontleedkunde (J.V.), Vrije Universiteit Brussel, 1090 Brussels, Belgium; Gastroenterologie (J.V.). Rijksuniversiteit Gent: and Department of Pathology and Liver Research Center (S.G.), Albert Einstein College of Medicine, Bronx, New York 10461 (OA 82-287P2).
authors.forename: Frank
authors.initials: F
authors.lastname: Roels
authors.affiliation: Menselijki Anatomie (F.R.; M.P.; A.C.; I.K.; P. v.d.S.), Gastroenterologie. Akademisch Ziekenhuis (G.G.), and Patologische Ontleedkunde (J.V.), Vrije Universiteit Brussel, 1090 Brussels, Belgium; Gastroenterologie (J.V.). Rijksuniversiteit Gent: and Department of Pathology and Liver Research Center (S.G.), Albert Einstein College of Medicine, Bronx, New York 10461 (OA 82-287P2).
authors.forename: Marina
authors.initials: M
authors.lastname: Pauwels
authors.affiliation: Menselijki Anatomie (F.R.; M.P.; A.C.; I.K.; P. v.d.S.), Gastroenterologie. Akademisch Ziekenhuis (G.G.), and Patologische Ontleedkunde (J.V.), Vrije Universiteit Brussel, 1090 Brussels, Belgium; Gastroenterologie (J.V.). Rijksuniversiteit Gent: and Department of Pathology and Liver Research Center (S.G.), Albert Einstein College of Medicine, Bronx, New York 10461 (OA 82-287P2).
authors.forename: Alfons
authors.initials: A
authors.lastname: Cornelis
authors.affiliation: Menselijki Anatomie (F.R.; M.P.; A.C.; I.K.; P. v.d.S.), Gastroenterologie. Akademisch Ziekenhuis (G.G.), and Patologische Ontleedkunde (J.V.), Vrije Universiteit Brussel, 1090 Brussels, Belgium; Gastroenterologie (J.V.). Rijksuniversiteit Gent: and Department of Pathology and Liver Research Center (S.G.), Albert Einstein College of Medicine, Bronx, New York 10461 (OA 82-287P2).
authors.forename: Ingrid
authors.initials: I
authors.lastname: Kerckaert
authors.affiliation: Menselijki Anatomie (F.R.; M.P.; A.C.; I.K.; P. v.d.S.), Gastroenterologie. Akademisch Ziekenhuis (G.G.), and Patologische Ontleedkunde (J.V.), Vrije Universiteit Brussel, 1090 Brussels, Belgium; Gastroenterologie (J.V.). Rijksuniversiteit Gent: and Department of Pathology and Liver Research Center (S.G.), Albert Einstein College of Medicine, Bronx, New York 10461 (OA 82-287P2).
authors.forename: Peter Van Der
authors.initials: PV
authors.lastname: Spek
authors.affiliation: Menselijki Anatomie (F.R.; M.P.; A.C.; I.K.; P. v.d.S.), Gastroenterologie. Akademisch Ziekenhuis (G.G.), and Patologische Ontleedkunde (J.V.), Vrije Universiteit Brussel, 1090 Brussels, Belgium; Gastroenterologie (J.V.). Rijksuniversiteit Gent: and Department of Pathology and Liver Research Center (S.G.), Albert Einstein College of Medicine, Bronx, New York 10461 (OA 82-287P2).
authors.forename: Gerda
authors.initials: G
authors.lastname: Goovaerts
authors.affiliation: Menselijki Anatomie (F.R.; M.P.; A.C.; I.K.; P. v.d.S.), Gastroenterologie. Akademisch Ziekenhuis (G.G.), and Patologische Ontleedkunde (J.V.), Vrije Universiteit Brussel, 1090 Brussels, Belgium; Gastroenterologie (J.V.). Rijksuniversiteit Gent: and Department of Pathology and Liver Research Center (S.G.), Albert Einstein College of Medicine, Bronx, New York 10461 (OA 82-287P2).
authors.forename: Jacques
authors.initials: J
authors.lastname: Versieck
authors.affiliation: Menselijki Anatomie (F.R.; M.P.; A.C.; I.K.; P. v.d.S.), Gastroenterologie. Akademisch Ziekenhuis (G.G.), and Patologische Ontleedkunde (J.V.), Vrije Universiteit Brussel, 1090 Brussels, Belgium; Gastroenterologie (J.V.). Rijksuniversiteit Gent: and Department of Pathology and Liver Research Center (S.G.), Albert Einstein College of Medicine, Bronx, New York 10461 (OA 82-287P2).
authors.forename: Sidney
authors.initials: S
authors.lastname: Goldfischer
keywords: Catalase; Cholestasis; Cirrhosis; Human liver; Malignancy.; Peroxisomes