title: Deficiency of scavenger receptor class B type 1 leads to increased atherogenesis with features of advanced fibroatheroma and expansive arterial remodeling.
abstract: BACKGROUND
  Scavenger receptor class B type 1 (SR-BI) is the main high-density lipoprotein (HDL) receptor in mammalians. Loss of SR-BI has been proven to disturb HDL metabolism and accelerate atherosclerosis. However, little is known about the plaque features and arterial remodeling in the increased atherogenesis caused by SR-BI deficiency. Here, we explored this issue in atherosclerosis-prone low-density lipoprotein receptor (LDL-R) knockout (KO) mice deficient of SR-BI.
  
  
  RESULTS
  SR-BI/LDL-R double KO (dKO) and control LDL-R KO mice were fed an atherogenic diet for 12 weeks. Compared with the plaques in the LDL-R KO controls, which were lipid-dominant and collagen-poor, the plaques in the dKO mice were significantly enlarged, with a massive accumulation of collagen but no significantly increased infiltration of lipids, macrophages, or smooth muscle cells. In addition, the plaques in the brachiocephalic sinus of the dKO mice typically contained a necrotic core topped with a thin fibrotic cap. The increased atherogenesis in the dKO mice led to a following expansion of the vessel walls; therefore, the lumen area in the dKO mice was even slightly enlarged.
  
  
  CONCLUSIONS
  We showed here that SR-BI deficiency led to increased atherogenesis with features of advanced fibroatheroma and expansive arterial remodeling in LDL-R KO mice fed an atherogenic diet.
authors.affiliation: Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, Dalian 116011, China; Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Peking University Health Science Center, Beijing 100191, China. Electronic address: liaojiawei@bjmu.edu.cn.
authors.forename: Jiawei
authors.initials: J
authors.lastname: Liao
authors.affiliation: Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Peking University Health Science Center, Beijing 100191, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Guo
authors.affiliation: Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Peking University Health Science Center, Beijing 100191, China; Department of Cardiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
authors.forename: Mengyu
authors.initials: M
authors.lastname: Wang
authors.affiliation: Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Peking University Health Science Center, Beijing 100191, China.
authors.forename: Mingming
authors.initials: M
authors.lastname: Gao
authors.affiliation: Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Peking University Health Science Center, Beijing 100191, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Shen
authors.affiliation: Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Peking University Health Science Center, Beijing 100191, China.
authors.forename: Yuhui
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Peking University Health Science Center, Beijing 100191, China. Electronic address: huangwei@bjmu.edu.cn.
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
authors.affiliation: Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Peking University Health Science Center, Beijing 100191, China.
authors.forename: George
authors.initials: G
authors.lastname: Liu
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000378:metabolism* / Q000473:pathology; D004036:Diet, Atherogenic; D004195:Disease Models, Animal; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D058226:Plaque, Atherosclerotic / Q000378:metabolism* / Q000473:pathology; D011973:Receptors, LDL / Q000172:deficiency; D051122:Scavenger Receptors, Class B / Q000378:metabolism*; D066253:Vascular Remodeling / Q000502:physiology*
chemical_list: D011973:Receptors, LDL; C454739:Scarb1 protein, mouse; D051122:Scavenger Receptors, Class B
keywords: Advanced fibroatheroma; Arterial remodeling; Plaque features; SR-Bi