title: MicroRNA-190b confers radio-sensitivity through negative regulation of Bcl-2 in gastric cancer cells.
abstract: OBJECTIVE
  To determine the role of miR-190b in radio-sensitivity of gastric cancer (GC).
  
  
  RESULTS
  In radio-resistant GC cells, down-regulation of miR-190b and up-regulation of Bcl-2 were observed. The protein expression of Bcl-2 was negatively regulated by miR-190b. Overexpression of miR-190b significantly decreased cell viability and enhanced radio-sensitivity of GC cells. Of note, these effects of miR-190b on GC cells radio-sensitivity were abolished by Bcl-2.
  
  
  CONCLUSIONS
  miR-190b confers radio-sensitivity of GC cells, possibly via negative regulation of Bcl-2.
authors.affiliation: Department of Gastroenterology, The First People's Hospital of XiangYang, Hubei University of Medicine, No. 15, Jiefang Road, Fancheng District, Xiangyang, 441000, Hubei, People's Republic of China.
authors.forename: Changzheng
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Gastroenterology, The First People's Hospital of XiangYang, Hubei University of Medicine, No. 15, Jiefang Road, Fancheng District, Xiangyang, 441000, Hubei, People's Republic of China. qiaochuanhu9116@126.com.
authors.forename: Chuanhu
authors.initials: C
authors.lastname: Qiao
mesh_terms: D045744:Cell Line, Tumor; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics / Q000378:metabolism*; D011836:Radiation Tolerance; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: C000595707:BCL2 protein, human; C576613:MIRN190 microRNA, human; D035683:MicroRNAs; D019253:Proto-Oncogene Proteins c-bcl-2
keywords: Bcl-2; Gastric cancer; MicroRNA-190b; Radio-sensitivity