title: T-type Ca2+channels and autoregulation of local blood flow.
abstract: L-type voltage gated Ca2+channels are considered to be the primary source of calcium influx during the myogenic response. However, many vascular beds also express T-type voltage gated Ca2+channels. Recent studies suggest that these channels may also play a role in autoregulation. At low pressures (40-80 mmHg) T-type channels affect myogenic responses in cerebral and mesenteric vascular beds. T-type channels also seem to be involved in skeletal muscle autoregulation. This review discusses the expression and role of T-type voltage gated Ca2+channels in the autoregulation of several different vascular beds. Lack of specific pharmacological inhibitors has been a huge challenge in the field. Now the research has been strengthened by genetically modified models such as mice lacking expression of T-type voltage gated Ca2+channels (CaV3.1 and CaV3.2). Hopefully, these new tools will help further elucidate the role of voltage gated T-type Ca2+channels in autoregulation and vascular function.
authors.affiliation: a Departments of Veterinary Clinical and Animal Sciences , University of Copenhagen , Copenhagen , Denmark.
authors.forename: Lars Jørn
authors.identifier: http://orcid.org/0000-0003-4559-7456
authors.initials: LJ
authors.lastname: Jensen
authors.affiliation: b Department of Biomedical Sciences, Faculty of Health and Medical Sciences , University of Copenhagen , Copenhagen , Denmark.
authors.forename: Morten Schak
authors.identifier: http://orcid.org/0000-0002-9718-5421
authors.initials: MS
authors.lastname: Nielsen
authors.affiliation: b Department of Biomedical Sciences, Faculty of Health and Medical Sciences , University of Copenhagen , Copenhagen , Denmark.
authors.forename: Max
authors.initials: M
authors.lastname: Salomonsson
authors.affiliation: b Department of Biomedical Sciences, Faculty of Health and Medical Sciences , University of Copenhagen , Copenhagen , Denmark.
authors.forename: Charlotte Mehlin
authors.identifier: http://orcid.org/0000-0002-9984-3125
authors.initials: CM
authors.lastname: Sørensen
mesh_terms: D000818:Animals; D020747:Calcium Channels, T-Type / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D008564:Membrane Potentials; D009119:Muscle Contraction; D012039:Regional Blood Flow
chemical_list: D020747:Calcium Channels, T-Type
keywords: T-type channel; autoregulation; blood flow; calcium