title: Intra-individual comparison of different gadolinium-based contrast agents in the quantitative evaluation of C6 glioma with dynamic contrast-enhanced magnetic resonance imaging.
abstract: This experiment aimed to compare the ionic (Gadodiamide, Gd-DTPA-BMA) and non-ionic (Gadopentetate dimeglumine, Gd-DTPA) gadolinium-based contrast agents (GBCA) in the quantitative evaluation of C6 glioma with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). A C6 glioma model was established in 12 Wistar rats, and magnetic resonance (MR) scans were performed six days after tumor implantation. Imaging was performed using a 3.0-T MR scanner with a 7-inch handmade circular coil. Pre-contrast T1 mapping and dynamic contrast-enhanced T1WI after a bolus injection (0.2 mL s-1) of GBCA at 0.4 mmol kg-1were performed. Each rat received two DCE-MRI scans, 24 h apart. The first and second scans were performed using Gd-DTPA-BMA and Gd-DTPA, respectively. Image data were processed using the Patlak model. Both Ktransand Vpmaps were generated. Tumors were manually segmented on all 3D Ktransand Vpmaps. Pixel counts and mean values were recorded for use in a paired t-test. Three radiologists independently performed the tumor segmentation and value calculation. The agreements from different observers were subjective to the intra-class correlation coefficient (ICC). Readers demonstrated that the pixel counts of tumors in Ktransmaps were higher with Gd-DTPA-BMA than with Gd-DTPA (P&lt;0.001, all readers). Although the Ktransvalues were higher with Gd-DTPA-BMA than with Gd-DTPA, there was no statistical significance (P&gt;0.05, all readers). The pixel counts of tumors in Vpmaps, as well as Vpvalues, showed no obvious difference between the two agents (P&gt;0.05, all readers). Excellent interobserver measurement reproducibility and reliability were demonstrated in the ICC tests. The Gd-DTPA-BMA contrast agent had significantly higher pixel counts of glioma in the Ktransmaps, and an increased tendency for average Ktransvalues, indicating that DCE-MRI with Gd-DTPA-BMA may be more suitable and sensitive for the evaluation of glioma.
authors.affiliation: Department of Radiology, PLA General Hospital, Beijing, 100853, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Radiology, PLA General Hospital, Beijing, 100853, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
authors.affiliation: Department of Radiology, PLA General Hospital, Beijing, 100853, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Lou
authors.affiliation: Department of Radiology, PLA General Hospital, Beijing, 100853, China.
authors.forename: Zhiye
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of Radiology, PLA General Hospital, Beijing, 100853, China. cjr.malin@vip.163.com.
authors.forename: Lin
authors.initials: L
authors.lastname: Ma
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism; D045744:Cell Line, Tumor; D003287:Contrast Media / Q000493:pharmacokinetics*; D019786:Gadolinium DTPA / Q000493:pharmacokinetics; D005910:Glioma / Q000000981:diagnostic imaging* / Q000378:metabolism; D007089:Image Enhancement / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D017208:Rats, Wistar; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; C064925:gadodiamide; D019786:Gadolinium DTPA
keywords: Gd-DTPA; Gd-DTPA-BMA; K trans; dynamic contrast enhanced MR; ionic; non-ionic