title: Nut Consumption and Lung Cancer Risk: Results from Two Large Observational Studies.
abstract: Background:Epidemiologic evidence on the association between nut consumption and lung cancer risk is limited.Methods:We investigated this relationship in the Environment and Genetics in Lung Cancer Etiology (EAGLE) study, a population-based case-control study, and the National Institutes of Health (NIH) American Association of Retired Persons (AARP) Diet and Health Study, a prospective cohort. We identified 2,098 lung cases for EAGLE and 18,533 incident cases in AARP. Diet was assessed by food frequency questionnaire for both studies. Multivariable ORs and HRs and respective 95% confidence intervals (CI) were calculated using unconditional logistic regression and Cox proportional hazards regression for EAGLE and AARP, respectively.Results:Higher frequency of intake of nut consumption was inversely associated with overall lung cancer risk (highest vs. lowest quintile, OREAGLE= 0.74; 95% CI, 0.57-0.95; HRAARP= 0.86; 95% CI, 0.81-0.91), regardless of smoking status. Results from the prospective cohort showed similar associations across histologic subtypes and a more pronounced benefits from nut consumption for those who smoked 1 to 20 cigarettes/day (OREAGLE= 0.61; 95% CI, 0.39-0.95; HRAARP= 0.83; 95% CI, 0.74-0.94).Conclusions:Nut consumption was inversely associated with lung cancer in two large population-based studies, and associations were independent of cigarette smoking and other known risk factors.Impact:To our knowledge, this is the first study that examined the association between nut consumption and lung cancer risk by histologic subtypes and smoking intensity.Cancer Epidemiol Biomarkers Prev; 26(6); 826-36. ©2017 AACR.
authors.affiliation: Environmental Epidemiology Branch, NIH, Bethesda, Maryland.|NCI, NIH, Bethesda, Maryland.
authors.forename: Jennifer T
authors.initials: JT
authors.lastname: Lee
authors.affiliation: Environmental Epidemiology Branch, NIH, Bethesda, Maryland.|NCI, NIH, Bethesda, Maryland.
authors.forename: Gabriel Y
authors.initials: GY
authors.lastname: Lai
authors.affiliation: NCI, NIH, Bethesda, Maryland.|Metabolic Epidemiology Branch, NIH, Bethesda, Maryland.
authors.forename: Linda M
authors.initials: LM
authors.lastname: Liao
authors.affiliation: NCI, NIH, Bethesda, Maryland.|Risk Factor Assessment Branch, Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, NIH, Bethesda, Maryland.
authors.forename: Amy F
authors.initials: AF
authors.lastname: Subar
authors.affiliation: Department of Clinical Sciences and Community Health, EPOCA, Epidemiology Research Center, University of Milan, Milan, Italy.|Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy.
authors.forename: Pier Alberto
authors.initials: PA
authors.lastname: Bertazzi
authors.affiliation: Department of Clinical Sciences and Community Health, EPOCA, Epidemiology Research Center, University of Milan, Milan, Italy.|Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy.
authors.forename: Angela C
authors.initials: AC
authors.lastname: Pesatori
authors.affiliation: NCI, NIH, Bethesda, Maryland.|Metabolic Epidemiology Branch, NIH, Bethesda, Maryland.
authors.forename: Neal D
authors.initials: ND
authors.lastname: Freedman
authors.affiliation: NCI, NIH, Bethesda, Maryland. lamt@mail.nih.gov landim@mail.nih.gov.|Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, NIH, Bethesda, Maryland.
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Landi
authors.affiliation: Environmental Epidemiology Branch, NIH, Bethesda, Maryland. lamt@mail.nih.gov landim@mail.nih.gov.|NCI, NIH, Bethesda, Maryland.
authors.forename: Tram Kim
authors.initials: TK
authors.lastname: Lam
mesh_terms: D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology* / Q000473:pathology; D008297:Male; D009754:Nuts / Q000009:adverse effects*; D011446:Prospective Studies; D012189:Retrospective Studies; D012307:Risk Factors