title: [Giant viruses: update, enigmas, controversies and perspectives].
abstract: Unlike microbes known in his time, the first virus (that of tobacco mosaic disease) was discovered by Ivanoski in 1892 because it was not retained by Chamberland's porcelain candles. For more than a century afterward, viruses were equated with this simple property that is still extensively used today (using modern 0,2 µm pore filters) as a practical criterion to delineate the "viral fraction" from other microbes in medical or environmental samples. The first documented exception to the simplistic criterion of particle size came with the discovery of Mimivirus, the viral nature of which was eventually recognized in 2003, following ten years during which it was mistaken for an obligate intracellular bacterium. Thirteen more years later, we now realize that non-filtering "giant viruses" are not rare, probably ubiquitous, and come in a large variety of virion shapes, genome sizes, gene contents, and replication strategies. Following a quick description of the 4 giant virus families known today, we discuss the enigmas, controversies and perspectives of conceptual revolutions that are brought about by this new and booming area of virology.
authors.affiliation: Information Génomique et Structurale, Aix-Marseille Université, CNRS (UMR7256), Institut de Microbiologie de la Méditerranée (FR3479), 13000 Marseille, France - Assistance Publique-Hôpitaux de Marseille, Marseille, France.
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Claverie
authors.affiliation: Information Génomique et Structurale, Aix-Marseille Université, CNRS (UMR7256), Institut de Microbiologie de la Méditerranée (FR3479), 13000 Marseille, France.
authors.forename: Chantal
authors.initials: C
authors.lastname: Abergel
mesh_terms: D000818:Animals; D000072139:Giant Viruses / Q000145:classification / Q000502:physiology*; D049672:History, 19th Century; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D056686:Mimiviridae / Q000502:physiology; D010802:Phylogeny; D014773:Virology / Q000266:history / Q000639:trends*