title: Bacillus cereusbacteraemia: comparison between haematologic and nonhaematologic patients.
abstract: Bacillus cereusbacteraemia can be severe, especially among patients with haematologic malignancy. We retrospectively reviewed first episodes of trueB. cereusbacteraemia (more than one positive bottle plus signs of infection) at our institution between 1997 and 2013 with the aim to compare haematologic versus nonhaematologic patients and analyse episodes with complicated outcome. Among 56 episodes of positive-blood cultures forB. cereus,21 were considered significant. Median age was 54 years (range 23-82 years). Ten patients (48%) had a haematologic malignancy; all were neutropenic at the time ofB. cereusbacteraemia. Nonhaematologic patients were either intravenous drug users (n= 3, 14%), polytraumatized (n= 3, 14%) or had multiple chronic comorbidities (n= 5, 24%). Most episodes were hospital acquired (15, 71%). Sources of bacteraemia were intravascular catheter (n= 11, 52%), digestive tract (n= 6, 29%), drug injection (n= 3, 14%) and wound (n= 1, 5%). Adequate antibiotic therapy was provided to 18 patients (86%) during a median of 17 days (range 2-253 days). The intravascular catheter was removed in eight cases (42%). Three haematologic patients had a complicated course with neurologic complications (meningoencephalitis and cerebral abscesses). Complications appeared to be associated with catheter infection (100% of complicated cases vs. 29% of noncomplicated cases). In conclusion,B. cereusbacteraemia can have a complicated course in a subset of patients, mainly those with haematologic malignancy. Catheter infection may be associated with a worse outcome with frequent neurologic complications.
authors.affiliation: Service of Infectious Diseases, Lausanne, Switzerland; Service of Internal Medicine, Department of Medicine, Lausanne, Switzerland.
authors.forename: S
authors.initials: S
authors.lastname: Tusgul
authors.affiliation: Institute of Microbiology, Department of Laboratories, Lausanne, Switzerland.
authors.forename: G
authors.initials: G
authors.lastname: Prod'hom
authors.affiliation: Service of Infectious Diseases, Lausanne, Switzerland; Service of Hospital Preventive Medicine, Lausanne, Switzerland.
authors.forename: L
authors.initials: L
authors.lastname: Senn
authors.affiliation: Department of Radiology, Lausanne University Hospital, Lausanne, Switzerland.
authors.forename: R
authors.initials: R
authors.lastname: Meuli
authors.affiliation: Service of Infectious Diseases, Lausanne, Switzerland.
authors.forename: P-Y
authors.initials: PY
authors.lastname: Bochud
authors.affiliation: Service of Infectious Diseases, Lausanne, Switzerland.
authors.forename: S G
authors.initials: SG
authors.lastname: Giulieri
keywords: Bacillus cereus; bacteraemia; central nervous system; intravascular catheter; neutropenia